USE OF A COMPOSITION FOR DERMATOLOGIC PREPARATION

Abstract: A composition for dermatologic preparation containing vitamin A and at least one powdery substance or at least one silicone oil selected between dimethylpolysiloxane and methylphenylpolysiloxane each having the viscosity of 2-20 cSt at 25 °C.

Description: The present invention is directed to the use of (i) at least one kind of powder or (ii) at least one silicone oil selected from the group consisting of dimethyl polysiloxane and methylphenyl polysiloxane having a viscosity of 2 - 20 cs at 25°C in the preparation of an external skin treatment composition comprising vitamin A for preventing stickiness caused by vitamin A. BACKGROUND ART It is known in the art that vitamin A is an effective component capable of preventing and treating skin hyperkeratosis and of preventing and recovering skin aging. However, vitamin A has a strong sticky feeling when applied, in addition to the above-mentioned effects, and therefore, this is a weakness of vitamin A when formulated into an external skin treatment composition. It is also known from European Patent Application n° 0255364 anhydrous cosmetic preparations for improving the appearance of the skin, comprising an emollient, a thickening agent and a working ingredient such as Vitamin A. European Patent Application n° 0440398 discloses skin care compositions comprising a water-in-oil emulsion, an antioxydant system, a chelating agent and a retinoid. None of these documents do relate to stickiness caused by Vitamin A nor to a solution to this problem. DISCLOSURE OF THE INVENTION Accordingly, the object of the present invention is to provide an external skin treatment composition capable of preventing stickiness caused by vitamin A, when formulated into an external skin treatment composition, and capable of remarkably improving the usability of vitamin A. The present invention is directed to the use of (i) a least one kind of powder of (ii) at least one silicone oil selected from the group consisting of dimethyl polysiloxane and methylphenyl polysiloxane having a viscosity of 2 - 20 cs at 25°C in the preparation of an external skin treatment composition comprising vitamin A for preventing stickiness caused by vitamin A. BEST MODE FOR CARRYING OUT THE INVENTION Vitamin A used in the present invention is also called retinol and all-trans products or 13-cis products can be preferably used, but the mixture thereof can also be used. There are no limitations to the amounts of vitamin A formulated into the external skin treatment composition according to the present invention, but the preferable amount is 0.0001 to 5% by weight, more preferably 0.001 to 0.5% by weight, in view of the effect of vitamin A to the skin. The powders used in the present invention include, for example, organic polymer powders such as nylon powder, polyethylene powder, cellulose powder, acrylic resin, etc., inorganic pigments, sintered pigments, organic pigments, such as mica, sericite, talc, kaolin, calcium carbonate, magnesium carbonate, zinc white, titanium dioxide, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, titanium coated mica, bismuth oxychloride, blood red, caking pigment, ultramarine pink, chromium hydroxide, titanated mica, yellow iron oxide, chromium oxide, aluminum chromium oxide, Prussian blue, black iron oxide, carbon black, magnesium silicate, mica, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, light calcium carbonate, heavy calcium carbonate, light magnesium carbonate, heavy magnesium carbonate, calamine, etc. and those obtained by appropriately surface treating of these powders. There are no specific limitation to the particle size of these powders, but preferably, the average particle size is 0.01 to 20 µm. The amount of the powder formulated according to the present invention is preferably 0.01% by weight or more and more preferably 0.1 to 80% by weight, in the total amount of the external skin treatment composition. The silicon oil (i.e., dimethyl polysiloxane or methylphenyl siloxane) used in the present invention has a viscosity of 2 - 20 cs (25°C), preferably 5 - 20 cs (25°C). The silicone oils having a purity conventionally used for an external skin treatment composition can be used in the present invention. Those having a viscosity of less than 2 cs are not preferable from a viewpoint of safety to the skin. On the other hand, when the viscosity is more than 20 cs, there are no problems from the safety standpoints, but the intended effects of suppressing the stickiness according to the present invention are not sufficient. Furthermore, there are no limitations for the methylphenyl polysiloxane if they are usable for external skin treatment agent. There are no specific limitations to the amount of the silicone oil formulated according to the present invention, but the amount is preferably 0.001 - 80.0% by weight, more preferably 1 - 80% by weight, based upon the total weight of the external skin treatment composition, in view of suppressing the stickiness of vitamin A. The external skin treatment composition according to the present invention can be in any form of bases, for example, in the form of a solution type, a solubilized type, an emulsified type, powder dispersion type, water-oil two layer type, water-oil-powder three layer type. The applications thereof are also widely spread in, for example, basic cosmetics such as cosmetic lotions, emulsions, creams, packs, make-up cosmetics such as lipsticks, foundations, mascaras, eyeshadows, eyeliners, cosmetic bases, eyebrow pencils, calamine lotions, hair cosmetics such as shampoos, rinses, hair tonics, and other cosmetics, and quasi-drugs. Among these, when used in cosmetic lotions, emulsions, creams, the present invention can prove its true effects. This is because the stickiness due to humectants is generally especially felt in the case of cosmetic lotions and the stickiness due to the oily components in the bases is further felt in the case of emulsions and creams. In addition to the above-mentioned essential components, the external skin treatment composition according to the present invention may optionally contain various components conventionally formulated into cosmetics, quasi-drugs such as humectants, surfactants, preservatives, water, alcohols, thickeners, the other oil components, powders, drugs, chelating agents, perfumes (or flavours), colorants, UV absorbers. INDUSTRIAL APPLICABILITY The external skin treatment composition is effective as an external skin treatment agent having no stickiness due to vitamin A, and good or excellent stability and safety, in spite of the fact that the external skin treatment composition is excellent, due to the formulation of vitamin A, in the prevention and treatment of skin hyperkeratosis and the prevention and recovery of skin aging. EXAMPLES The present invention will now be further illustrated by no means limited to, the following Examples, in which the amounts formulated are "% by weight". Example 1-1: Cosmetic oil % Olive oil 50.0 Isopropyl myristate 20.0 Squalane 20.0 Vitamin A 5.0 Powder (talc) 5.0 Comparative Example 1-1 The cosmetic oil of Comparative Example 1-1 was obtained in the same manner as in Example 1-1 except that the powder was removed. The useability (i.e., stickiness) of Example 1-1 and Comparative Example 1-1 was evaluated by the judgement of a panel composed of 10 women's beauty specialists, who actually use The Samples. (Evaluation standard) A: No stickiness B: Slight stickiness, but practically acceptable C: Sticky D: Remarkable stickiness The results are shown in Table 1-1. Evaluation of feeling upon use by cosmetic technical experts Overall evaluation Example 1-1 A A A A A A B A A A A Comparative Example 1-1 C D D B C B C D D C C As is clear from the above results, the powder prevents stickiness of vitamin A. Example 1-2: Foundation (Oil phase) % Stearyl alcohol 3.0 Stearic acid 2.0 Squalane 5.0 POE(25) Cetyl ether 1.0 Glyceryl monostearate 1.0 Ethyl paraben 0.2 Vitamin A 0.5 (Powder phase) Titanium dioxide 3.0 Talc 3.0 Kaolin 1.4 Iron oxide 2.6 (Aqueous phase) Propylene glycol 3.0 Triethanolamine 1.0 Purified water Balance (Preparation method) The oil phase was heated under stirring, followed by dispersing the powder phase therein. The resultant dispersion was added to the aqueous phase similarly heated under stirring, to form the emulsion. The emulsion thus obtained was cooled under stirring to form the foundation. Example 1-3: Compact foundation % Methylphenylpolysiloxane (degree of polymerization 250) 15.0 Liquid paraffin 3.0 Isopropyl myristate 2.0 Stearic acid 1.0 Ethyl paraben 0.5 Vitamin A 1.0 Powder preparation 77.5 (Preparation method) The compact foundation was obtained in a conventional manner. Example 1-4: Foundation lotion (Oil phase) % Stearic acid 2.0 Cetanol 0.3 Liquid paraffin 5.0 Butyl paraben 0.05 POE(10) oleate 1.0 Sorbitan trioleate 1.0 Vitamin A 10.0 (Powder phase) Powder preparation 10.5 (Aqueous phase) Ethanol 5.0 Propylene glycol 5.0 Triethanolamine 1.0 Carboxymethyl cellulose 0.3 Hibitane-gluconate Digluconate 0.05 Purified water Balance (Preparation method) According to Example 1-2 Example 1-5: Oily foundation % Vitamin A 0.1 Powder preparation 43.0 Microcrystalline wax 10.0 Sorbitan sesquioleate 1.0 Propyl paraben 0.5 Liquid paraffin Balance (Preparation method) The components other than the powder preparation and vitamin A were dissolved by heating and stirring, followed by adding the powder preparation and vitamin A. The mixture was uniformly mixed, while the overall temperature was maintained. The mixture was filled in an inner dish , followed by cooling to obtain the oily foundation. Example 1-6: Eyeshadow % Powder preparation 92.1 Beeswax 2.0 Hexadecyl palmitate 5.0 Glyceryl monostearate 0.5 Vitamin A 0.2 Perfume 0.3 (Preparation method) According to Example 1-2 Example 1-7: Calamin lotion % Zinc 1.3 Serisite 3.0 Iron oxide 0.05 Glycerol 2.0 Camphor 0.2 Phenol 10.0 POE(60) hydrogenated castor oil 0.6 Vitamin A 0.001 Purified water Balance (Preparation method) The calamin lotion was obtained by sufficiently mixing all the components under stirring. Example 1-8: Base cream % Propylene glycol 5.0 Potassium hydroxide 0.2 Glycerol 3.0 Talc 1.0 Kaolin 2.0 Iron oxide 0.1 Liquid paraffin 10.0 Vaseline 5.0 Stearic acid 2.0 Cetyl alcohol 2.0 Lanolin 2.0 Stearic monoglyceride 2.0 Ethyl paraben 0.3 Perfume 0.2 Isopropyl myristate 0.5 Vitamin A 1.0 Purified water Balance (Preparation method) The base cream was obtained according to a conventional manner. Example 1-9: Night cream % Liquid paraffin 18.0 Vaseline 7.0 Isopropyl myristate 5.0 Polyethylene powder 4.0 Butyl paraben 0.2 Vitamin A 0.1 Diglycerine monooleate 2.0 Diglycerine triisostearate 2.0 Glycerol 7.0 Cellulose powder 3.0 Yellow iron oxide 0.05 Purified water Balance (Preparation method) The night cream was obtained according to a conventional manner. The products of Examples 1-2 to 1-9 were external skin treatment agents, which were excellent in the prevention and treatment of skin hyperkeratosis and the prevention and recovery of skin aging and also which did not exhibit roughening. Example 2-1: Cosmetic lotion % Ethanol 20.0 1,3-Butylene glycol 5.0 Vitamin A 0.0001 Polyoxyethylene (50 mol) oleyl ether 0.8 Ethyl paraben 0.1 Dimethyl polysiloxane (10 cs) 0.001 Purified water Balance (Preparation method) In ethanol, vitamin A, dimethyl polysiloxane, POE oleyl ether and ethyl paraben were dissolved. Separately, the purified water and 1,3-butylene glycol were dissolved. The ethanol phase was added to the aqueous phase, followed by solubilizing to obtain the cosmetic lotion. Comparative Example 2-1 The cosmetic oil of Comparative Example 2-1 was obtained in the same manner as in Example 2-1 except that the dimethyl polysiloxane was removed. The useability (i.e., stickiness) of Example 2-1 and Comparative Example 2-1 was evaluated by the judgement of a panel composed of 10 women's beauty specialists, who actually use The Samples. The results are shown in Table 2-1. Evaluation of feeling upon use by cosmetic technical experts Overall evaluation Example 2-1 A A A A A A B A A A A Comparative Example 2-1 C D D B C B C D D C C As is clear from the above results, the silicone oil prevents the stickiness of vitamin A. Example 2-2: Cleansing cream % (A) Cetanol 3.0 Beeswax 1.0 Solid paraffin 1.0 Stearic acid 2.0 Vaseline 10.0 Liquid paraffin 15.0 POE(20) Sorbitan stearate 2.4 Diglycerine distearate 2.6 Vitamin A 0.5 Nylon powder (Ave. particle size 1 µ) 3.0 Methylphenyl polysiloxane (degree of polymerization 250) 20.0 Propyl paraben 0.3 Perfume 0.3 (B) Dipropylene glycol 5.0 Potassium hydroxide 0.08 Purified water Balance (Preparation method) The oil phase (A) and the aqueous phase (B) were separately dissolved by heating and stirring. The oil phase was added to the aqueous phase, followed by emulsifying and cooling, to obtain the cream. Example 2-3: Nutritious emulsion % (A) Beeswax 1.0 Vaseline 2.0 Deodored lanolin 1.5 Jojoba oil 6.0 Cetyl isooctanoate 4.0 Glyceryl monostearate 2.0 POE-20-octyl dodecanol 2.0 Ethyl paraben 0.2 Butyl paraben 0.1 Vitamin A 0.3 Dimethyl polysiloxane (20 cs) 1.0 Perfume 0.3 (B) Dipropylene glycol 2.0 Carboxyvinyl polymer 0.2 L-alginine 0.2 Purified water Balance (Preparation method) According to Example 2-2 Example 2-4: Foundation % (A) Cetanol 3.5 Stearic acid 2.0 Deodored lanolin 5.0 Vaseline 2.0 Squalane 8.0 Glyceryl monooleate 2.5 POE(10) behenyl alcohol 0.5 Ethyl paraben 0.2 Butyl paraben 0.2 Vitamin A 5.0 Dimethyl polysiloxane (2 cs) 0.5 1,3-Butylene glycol 2.0 Powder preparation 15.0 Triethanolamine 0.25 Purified water Balance (Preparation method) According to Example 2-4 Example 2-5: Cosmetic lotion % (A) Purified water Total amount to 100 Glycerol 2.0 1,3-Butylene glycol 2.0 (B) Ethanol 15.0 Purified lecithin 0.02 POE(60) hydrogenated castor oil 1.0 Vitamin A 0.00001 Dimethyl polysiloxane (6 cs) 0.001 Perfume 0.05 Methyl paraben 0.1 (Preparation method) The aqueous phase (A) and the alcoholic portion (B) were separately dissolved uniformly and the alcoholic portion was added to the aqueous phase, followed by solubilizing to obtain the cosmetic lotion. Example 2-6: Aqueous essence % (A) Purified water Total amount to 100 Glycerol 2.0 1,3-Butylene glycol 10.0 Maltitol 2.0 Sodium hyaluronate 0.2 Dipropylene glycol 5.0 Carboxyvinyl polymer 0.5 (B) Ethanol 5.0 POE(60) hydrogenated castor oil 1.0 Vitamin A 0.1 Methylphenyl polysiloxane 3.0 Perfume 0.05 Methyl paraben 0.2 (C) Potassium hydroxide 0.1 (Preparation method) The aqueous phase (A) and the alcoholic portion (B) were separately dissolved uniformly and the alcoholic portion was added to the aqueous phase, followed by solubilizing, and the potassium hydroxide (C) was added thereto, to obtain the cosmetic lotion. Example 2-7: Cosmetic oil % Dimethyl polysiloxane (6 cs) 40.0 Methylphenyl polysiloxane 40.0 Isopropyl myristate 15.0 Vitamin A 5.0 Perfume q.s. (Preparation method) The cosmetic oil was obtained in a conventional manner. Example 2-8: Night cream % Squalane 10.0 Isopropyl myristate 5.0 Methylphenyl polysiloxane 5.0 Dimethyl polysiloxane (5 cs) 7.0 Vaseline 4.0 Diglycerine diisostearate 3.0 Glyceryl monooleate 1.0 Butyl paraben 0.1 Vitamin A 0.3 Glycerol 20.0 Dipropylene glycol 3.0 Magnesium sulfate 0.3 Purified water Balance (Preparation method) The night cream was obtained in accordance with a conventional manner. The external skin treatment agents of Examples 2-2 to 2-8 were excellent in the prevention and treatment of skin hyperkeratosis and the prevention and recovery of skin aging and also were not sticky.

Claims: Use of a component selected from the group consisting of (i) at least one kind of powder or (ii) at least one silicone oil selected from the group consisting of dimethyl polysiloxane and methylphenyl polysiloxane having a viscosity of 2 - 20 cs at 25°C in the preparation of an external skin treatment composition comprising vitamin A for preventing stickiness caused by vitamin A. Use according to claim 1, wherein the amount of vitamin A formulated in the composition is 0,0001 to 5,0% by weight, based upon the total amount of the composition. Use according to one of claims 1 and 2, wherein said component is at least one powder selected from the group consisting of polymer powders, inorganic powders, sintered pigments and organic pigments. Use according to one of claims 1 and 3, wherein said amount of the powder formulated in the composition is 0,01 % by weight or more, based upon the total weight of the external skin treatment composition. Use according to one of claims 1 and 2, wherein said component is the silicone oil. Use according to one of claims 1, 2 and 5, wherein the amount of the silicone oil formulated is 0,001 to 80% by weight, based upon the total weight of the external skin treatment composition.

Inventors: SAKAMOTO OKIHIKO, YANAGIDA TAKESHI, SAKAMOTO, OKIHIKO, YANAGIDA, TAKESHI, SAKAMOTO, OKIHIKO THE SHISEIDO RESEARCH CENTER, YANAGIDA, TAKESHI THE SHISEIDO RESEARCH CENTER
Applicants: SHISEIDO CO LTD, SHISEIDO COMPANY, LTD.
Application year: 1993
Main classification: A61K7
IPC codes: A61K8, A61Q19, A61Q1, A61K31