HYDROXYETHYLAMINO SULFAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS

Abstract: Hydroxyaminoethyl sulphamic acid compounds of formulae (I) and (II), wherein R, R', R<1>, R<1'>, R<1''>, R<2>, R<3>, R<4>, R<5>, R<6>, x, t, Y, P<1> and P<2> are as defined in Claims 1 and 97, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Description: HYDROXYETHYLAMINO SULFAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to retroviral protease inhibitors and, more particularly, relates to novel compounds and a composition and method for inhibiting retroviral proteases. This invention, in particular, relates to sulfamic acid derivatives of hydroxyethylamine protease inhibitor compounds, a composition and method for inhibiting retroviral proteases such as human immunodeficiency virus (HIV) protease and for treating a retroviral infection, e.g., an HIV infection. The subject invention also relates to processes for making such compounds as wel. as to intermediates useful in such processes. 2. Related Art During the replication cycle of re ^ roviruses, gag and gag-pol gene products are translated as proteins. These proteins are subsequently processed by a virally encoded protease (or proteinase) to yield viral enzymes and structural proteins of the virus core. Most commonly, the gag precursor proteins are processed into the core proteins and the pol precursor proteins are processed into the viral enzymes, e.g., reverse transcriptase and retroviral protease. It has been shown that correct processing of the precursor proteins by the retroviral protease is necessary for assembly of infectious virons. For example, it has been shown that frameshift mutations in the protease region of the pol gene of HIV prevents processing of the gag precursor protein. It has also been shown through site-directed mutagenesis of an aspartic acid residue in the HIV protease that processing of the gag precursor protein is prevented. Thus, attempts have been made to inhibit viral replication by inhibiting the action of retroviral proteases. Retroviral protease inhibition may involve a transition-state mimetic whereby the retroviral protease is exposed to a mimetic compound which binds to the enzyme in competition with the gag and gag-pol proteins to thereby inhibit replication of structural proteins and, more importantly, the retroviral protease itself. In this manner, retroviral replication proteases can be effectively inhibited. Several classes of compounds have been proposed, particularly for inhibition of proteases, such as for inhibition of HIV protease. Such compounds include hydroxyethylamine isosteres and reduced amide isosteres. See, for example, EP 0 346 847; EP 0 342,541; Roberts et al, "Rational Design of Peptide-Based Proteinase Inhibitors, "Science, 248, 358 (1990); and Erickson et al, "Design Activity, and 2.8A Crystal Structure of a C2 Symmetric Inhibitor Complexed to HIV-1 Protease," Science, 249, 527 (1990). Several classes of compounds are known to be useful as inhibitors of the proteolytic enzyme renin. See, for example, U.S. No. 4,599,198; U.K. 2,184,730; G.B. 2,209,752; EP 0 264 795; G.B. 2,200,115 and U.S. SIR H725. Of these, G.B. 2,200,115, GB 2,209,752, EP 0 264,795, U.S. SIR H725 and U.S. 4,599,198 disclose urea- containing hydroxyethylamine renin inhibitors. G.B. 2,200,115 also discloses sulfamic acid-containing hydroxyethylamine renin inhibitors, and EP 0264 795 discloses certain sulfamic acid-containing hydroxyethylamine renin inhibitors. However, it is known that, although renin and HIV proteases are both classified as aspartyl proteases, compounds which are effective renin inhibitors generally cannot be predicted to be effective HIV protease inhibitors. BRIEF DESCRIPTION OF THE INVENTION The present invention is directed to virus inhibiting compounds and compositions. More particularly, the present invention is directed to retroviral protease inhibiting compounds and compositions, to a method of inhibiting retroviral proteases, to processes for preparing the compounds and to intermediates useful in such processes. The subject compounds are characterized as sulfamic acid derivatives of hydroxyethylamine inhibitor compounds. DETAILED DESCRIPTION OF THE INVENTION In accordance with the present invention, there is provided a retroviral protease inhibiting compound of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof wherein: R represents hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, alkoxycarbonyl, aryloxyalkyl, heteroaryloxyalkyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, ary1oxycarbony1, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxycarbonyl, heteroaroyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or wherein said aminocarbonyl and aminoalkanoyl radicals are disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen, radicals as defined for R3 or R"Sθ 2 - wherein R" represents radicals as defined for R 3 ; or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radicals; Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3) 2 (SCH3) , -C(CH 3 ) 2 (SC 6 H 5 ) , -C(CH3)2(S[0]CH3) , -C (CH3) 2 (S [0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert- leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonme, serine, O-alkyl serine, aspartic acid, beta-cyanoaianine and valine side chains; R!' and Rl" independently represent hydrogen and radicals as defined for Rl» or one of R 1 ' and Rl", together with Rl and the carbon atoms to which Rl, Rl ' and Rl" are attached, represent a cycloalkyl radical; R2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radials, -Nθ2, -CN, -CF3, -OR9 and -SR9 , wherein R9 represents hydrogen and alkyl radicals; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone and sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R3 or together with a nitrogen atom to which they are bonded form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and aryl radicals and the sulfone and sulfoxide derivatives thereof; R6 represents hydrogen and alkyl radicals; x represents 1 or 2; t represents either 0, 1 or 2; and Y represents 0, S and NR15 wherein R--- > represents hydrogen and radicals as defined for R^ . A family of compounds of particular interest within wherein: R represents hydrogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxycarbonyl, alkoxyalkyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy-carbonyl, heteroaroyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl. heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical or aminocarbonyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R3 or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3, -C02CH3, -CONH2, -CH2C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3)2 (SCH3) , -C(CH 3 ) 2 (SC 6 H 5 ) , -C(CH3)2(S[0]CH3) , -C (CH3) (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert- leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-methyl serine, aspartic acid, beta-cyanoalanine and valine side chains; R2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R9 represents hydrogen and alkyl radicals; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals. A more preferred family of compounds within Formula II consists of compounds wherein: R represents hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbony1, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy- carbonyl, heteroaroyl, aryloxyalkyl, heteroaryloxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl. and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyL, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminocarbonyl or aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl 5 radical; Rl represents CH2C (0)NHCH 3 , C (CH 3 ) 2 (SCH 3 ) , C(CH 3 ) 2 (S[0]CH 3 ) , C(CH 3 )2(S[0] 2 CH 3 ) , alkyl, alkenyl and alkynyl radicals, and amino acid side chains selected 0 from the group consisting of asparagine, valine, threonine, allo-threonine, isoleucine, tert-leucine, S-methyl cysteine and methionine and the sulfone and sulfoxide derivatives thereof, alanine, and allo- isoleucine; 5 R represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented by the formula -OR9 and -SR9 wherein R9 represents alkyl radicals; and 0 R3 represents alkyl, haloalkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl and heteroaralkyl radicals; and 5 R 4 and R 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals, or R^ and R 5 together with the nitrogen atom to 0 which they are bonded from a heterocycloalkyl or heteroaryl radical. Of highest interest are compounds within Formula II wherein 35. R represents alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy-carbonyl, heteroaroyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to Which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents CH 2 C(0)NHCH 3 , C (CH 3 ) 2 (SCH 3 ) , C(CH 3 ) 2 (S[0]CH 3 ) , C(CH 3 ) 2 (S[0] 2 CH 3 ) , methyl, propargyl, t-butyl, isopropyl and sec-butyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, S-methyl cysteine, allo-iso-leucine, iso-leucine, and beta-cyano alanine side chains; R2 represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals; R represents propyl, isoamyl, n-butyl, isobutyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals; and R 4 and R 5 independently represent hydrogen and methyl, ethyl, i-propyl, n-butyl, t-butyl, 1, 1-dimethylpropyl and phenyl radicals, or together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or N' -alkylpiperazi yl radical. Another family of compounds of particular interest within Formula I are compounds embraced by Formula III: wherein: R represents hydrogen, alkoxycarbonyl, aralkoxycarbony1, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbony1, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy-carbonyl, heteroaroyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl, and mono- an disubstituted aminocarbonyl and mono- and disubstituted .aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, sai .substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R3 or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, -CH2SO2NH2, -CH2CO?CH3, -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C(CH 3 ) 2 (SH) , -C (CH3) 2 (SCH3) , -C(CH3)2(S[0]CH3) , -C (CH3)2 (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isolet'. xne, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, aspartic acid, beta-cyano alanine and valine side chains; Rl ' and Rl" independently represent hydrogen and radicals as defined for Rl' or one of Rl ' and Rl", together with Rl and the carbon atoms to which Rl, Rl ' and Rl" are attached, represent a cycloalkyl radical; R 2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radialε, -NO2 , -C≡N, CF 3 , -OR9 and -SR9, wherein R9 represents hydrogen and alkyl radicals; R represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals. A more preferred family of compounds within Formula III consists of compounds wherein R represents an arylalkanoyl, heteroaroyl, aryloxyalkanoyl, aryloxycarbonyl, alkanoyl, aminocarbonyl, mono-substituted aminoalkanoyl, or disubstituted aminoalkanoyl, or mono-or dialkylaminocarbonyl radical; R' represents hydrogen and radicals as defined for R3 or R and R' together with the nitrogen to which they are attached represent a heterocycloalkyl or heteroaryl radical; R!» R! ' and R!" independently represent hydrogen and alkyl radicals having from 1 to about 4 carbon atoms, alkenyl, alkynyl, aralkyl radicals, and radicals represented by the formula -CH2C(0)R" or -C(0)R" wherein R" represents R 8, _ N R38R39 a nd 0R38 wherein R38 and R 9 independently represent hydrogen and alkyl radicals having from 1 to about 4 carbon atoms; F.2 represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented by the formula -0R9 and -SR9 wherein R represents hydrogen and alkyl radicals; and R represents alkyl, haloalkyl, alkenyl, alkynyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl radicals; and R 4 and R 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals, or R4 and R 5 together with the nitrogen atom to which they are bonded from a heterocycloalkyl or heteroaryl radical. Of highest interest are compounds of Formula III wherein: R represents an arylalkanoyl, aryloxycarbonyl, aryloxyalkanoyl, alkanoyl, aminocarbonyl, mono- substituted aminoalkanoyl, or disubstituted aminoalkanoyl, or mono-or dialkylaminocarbonyl radical; P. 1 represents hydrogen and radicals as defined for R3 or R and R' together with the nitrogen to which they are attached represent a heterocycloalkyl or heteroaryl radical; R ' R! ' and R!" independently represent hydrogen, methyl, ethyl, benzyl, phenylpropyl, -C(0)NH2 and propargyl radicals; R represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals; R3 represents propyl, isobutyl, isoamyl, n-butyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals; and R4 and R 5 independently represent hydrogen and methyl, ethyl, i-propyl, n-butyl, t-butyl, 1, 1-dimethylpropyl, cyclohexyl and phenyl radicals, or together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl radical. Another family of compounds of particular interest within Formula I are compounds embraced by Formula IV: wherein: R represents hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl , hydroxyalkyl, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl , aryloxyalkanoyl , heterocyclylcarbony1, heterocyclyloxycarboayl, heterocyclylalkanoyl, heterocyclylalkoxycarbony1.. heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy- carbonyl, heteroaroyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for 3 or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH? ) 2 (SCH3) , -C(CH 3 ) 2 (SC β H 5 ) , -C(CH3)2 (S.OJCH3) , -C (CH312 (S[0] 2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methioni e and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert- leucine, phenylalanine, ornithine, histidine. norleucine, glutamine, threonine, glycine, allo-threonin.*_ , serine, aspartic acid, beta-cyano alanine and valine side chains; R 2 represents alkyl, aryl, cycloalkyl, cyc oalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkvl and halogen radicals, -NO2, -C≡N, CF 3 -OR9, -SR9, wherein R9 represents hydrogen and alkyl; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl. radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide derivatives thereof; R4 and R^ independently represent hydrogen and radicals as defined for R or together with a nitrogen atom to which they are bonded form a heterocycloalkyl or a heteroaryl radical. A more preferred family of compounds within Formula IV consists of compounds wherein R represents hydrogen, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoy1, heterocyclylcarbonyl, heterocyclyloxycarbony1, heterocyclylalkanoyl, heterocyclylalkoxycarbony1, heteroaralkanoyl, heteroaralkoxycarbonyl , heteroaryloxy-carbonyl, heteroaroyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R3 or R and R' together with the nitrogen to which tney are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, alkyl and alkenyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, threonine, allo-threonine, isoleucine, tert-leucine, S-methyl cysteine and the sulfone and sulfoxide derivatives thereof, alanine, and allo-isoleucine; R represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented by the formula -OR9 and -SR9 wherein P.9 represents hydrogen and alkyl and halogen radicals; R represents alkyl, halalkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl radicals; and P. 4 and P. 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterc-ycloalkylalkyl radicals, or R 4 and R 5 together with the nitrogen atom to which they are bonded from a heterocycloalkyl or heteroaryl radical. Of highest interest are compounds within Formula IV wherein R represents hydrogen, alkoxycarbonyl, aralkoxycarbony1, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkan yl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy-carbonyl, heteroaroyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or hereroaryl radical; R' represents hydrogen and radicals as defined for P.3 or R and R' together with the nitrogen to whi-:h they are attached represent heterocycloalkyl and het.eroaryl radical; Rl represents hydrogen, methyl, propargyl, t-butyl, isopropyl and sec-butyl radicals, and amino acid side chains selected from the group consisting :>i asparagine, valine, S-methyl cysteine, allo-iso-leucin-. , iεo-leucine, threonine, serine, aspartic acid, beta-cya.:o alanine, and allo-threonine side chains; P.2 represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals; R 3 represents propyl, isobutyl, isoamyl, n-butyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals; and R4 and R 5 independently represent hydrogen and methyl, ethyl, i-propyl, n-butyl, t-butyl, 1, 1-dimethylpropyl , cyclohexyl and phenyl radicals, or R 4 and P, 5 together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl radical. As utilized herein, the term "alkyl", alone or in combination, means a straight-chain or branched-chain alkyl radical containing from 1 to about 10, preferably from 1 to 8, carbon atoms. Examples of such radicals include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, iso-amyl, hexyl, octyl and the like. The term "alkenyl", alon or in combination, means a straight-chain or branched-chain hydrocarbon radial having one or more double bonds and containing from 2 to about 18 carbon atoms preferably from 2 to 8 carbon atoms. Examples of suitable alkenyl radicals include ethenyl, propenyl, 1, 4-butadienyl, 12-octadecene and the like. The term "alkynyl", alone or in combination, means a straight-chain hydrocarbon radical having one or more triple bonds and containing from 2 to about 10 carbon atoms, preferably from 2 to 8 carbon atoms. Examples of alkynyl radicals include ethynyl, prσpynyl, (propargyl) , butynyl and the like. The term "alkoxy", alone or in combination, means an alkyl ether radical wherein the term alkyl 'is as defined above. Examples of suitable alkyl ether radicals include methoxy, ethoxy, n-propoxy, isopropoxy, n-outoxy, iso-butoxy, sec-butoxy, tert-butoxy and the like. The term "cycloalkyl", alone or in combination, means a saturated or partially saturated monocyclic, bicyclic or tricyclic alkyl radical wherein each cyclic moiety contains from about 3 to about 8 carbon atoms and is cyclic. The term "cycloalkylalkyl" means an alkyl radical as defined above which is substituted by a cycloalkyl radical containing from about 3 to about 8, preferably from 3 to 6 carbon atoms. Examples of such cycloalkyl radicals include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and the like. The term "aryl", alone or in combination, means a phenyl or naphthyl radical which optionally carries one or more substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, nitro, cyano, haloalkyl and the like, such as phenyl, p-tolyl, 4-methoxyphenyl, 4- (tert-butoxy)phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-hydroxyphenyl, 1-naphthyl, 2-naphthyl, and the like. The term "aralkyl", alone or in combination, means an alkyl radical as defined above in which one hydrogen atom is replaced by an aryl radical as defined above, such as benzyl, 2-phenylethyl and the like. The term "aralkoxy carbonyl", alone or in combination, means a radical of the formula -C (0) -O-aralkyl in which the term "aralkyl" has the significance given above. An example of an aralkoxycarbonyl radical is benzyloxycarbonyl. The term "aryloxy" means a radical of che formula aryl-O- in which the term aryl has the significance given abov . The term "alkanoyl", alone or in combination, means an acyl radical derived from an alkanecarboxylic acid wherein alkane means a radical as defined above for alkyl. Examples of alkanoyl radicals include acetyl, propionyl, butyryl, valeryl, 4-methylvaleryl, and the like. The term "cycloalkylcarbonyl" means an acyl group derived from a monocyclic or bridged cycloalkanecarboxylic acid such as cyclopropanecarbonyl , cyclohexanecarbonyl, adamantanecarbonyl, and the like, or from a benz-fused monocyclic cycloalkanecarboxylic acid which is optionally substituted by, for example, alkanoylamino, such as 1,2,3, 4-tetrahydro-2-naphthoyl, 2-acetamido-l,2, 3, 4- tetrahydro-2-naphthoyl. The term "aralkanoyl" means an acyl radical derived from an aryl-substituted alkanecarboxylic acid such as phenylacetyl, 3-phenylpropionyl (hydrocinnamoyl) , 4-phenylbutyryl, (2-naphthyl)acetyl, 4-chlorohydrocinnamoy1, 4-aminohydrocinnamoyl, 4-methoxyhydrocinnamoyl, and the like. The term "aroyl" means an acyl radical derived from an aromatic carboxylic acid. Examples of such radicals include aromatic carboxylic acids, an optionally substituted benzoic or naphthoic acid such as benzoyl, 4-chlorobenzoyl, 4-carboxybenzoyl, 4- (benzyloxycarbonyl)benzoyl , 1-naphthoyl, 2-naphthoyl, 6-carboxy-2 naphthoyl, 6- (benzyloxycarbonyj.) -2-naphthoyl, 3-benzyloxy-2-naphthoyl, 3-hydroxy-2-naphthoyl, 3- (benzyloxyformamido) -2-naphthoyl, and the like. The heterocyclyl or heterocycloalkyl portion of a heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkoxycarbonyl, or heterocyclyalkyl group or the like is a saturated or partially unsaturated monocyclic, bicyclic or tricyclic heterocycle which contains one or more hetero atoms selected from nitrogen, oxygen and sulphur, which is optionally substituted on one or more carbon atoms by halogen, alkyl, alkoxy, oxo, and the like, and/or on a secondary nitrogen atom (i.e., -NH-) by alkyl, aralkoxycarbonyl, alkanoyl, phenyl or phenylalkyl or on a tertiary nitrogen atom (i.e. = N- ) by oxido and which is attached via a carbon atom. The heteroaryl portion of a heteroaroyl, heteroaryloxycarbonyl, or a heteroaralkoxy corbonyl group or the like is an aromatic monocyclic, bi y.:lic, or tricyclic heterocycle which contains the hetero atoms and is optionally substituted as defined above with respect to the definition of heterocyclyl. Such heterocyclyl and heteroaryl radicals have from four to about 12 ring members, preferably from 4 to 10 ring members. Examples of such heterocyclyl and heteroaryl groups are pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiamorpholinyl, pyrrolyl, imidazolyl (e.g., imidazol 4-yl, l-benzyloxycarbonylimidazol-4-yl, etc.), pyrazolyl, pyridyl, pyrazinyl, pyrimidinyl, furyl, thienyl, triazolyl, oxazolyl, thiazolyl, indolyl (e.g., 2-indolyl, etc.), quinolinyl, (e.g., 2-quinolinyl, 3-quinolinyl, l-oxido-2-quinolinyl, etc.), isoquinolinyl (e.g., 1-isoquinolinyl, 3-isoquinolinyl, etc.), tetrahydroσuinolinyl (e.g., 1,2, 3 , 4-tetra.ιydι _--2- quinolyl, etc.), 1,2, 3 , 4-tetrahydroisoquinolinyl (e.g., 1,2,3, 4-tetrahydro-l-oxo-isoquinolinyl, etc. ) , quinoxalinyl, β-carbolinyl, 2-benzofurancarbonyl, l-,2-,4- or 5-benzimidazolyl , and the like. The term "cycloalkylalkoxycarbonyl" means an acyl group derived from a cycloalkylalkoxycarboxylic acid of the formula cycloalkylalkyl-O-COOH wherein cycloalkyla kyl has the significance given above. The term "aryloyyalkanoyl" means an acyl radical of the formula aryl-D-alkanoyl wherein aryl and alkanoyl have the significance given above. The term "heterocyclyloxycarbonyl " means an acyl group derived from heterocyclyl-O-COOH whe_ ein heterocyclyl is as defined above. The term "heterocyclylalkanσyl " is an acyl radical derived from a heterocyclyl-substituted alkane carboxyli ._'ld wherein heterocyclyl has the significance given above. The term "heterocyclylalkoxycarbonyl" means an acyl radical derived from a heterocyclyl-substituted alxane-O-COOH wherein heterocyclyl has the significance given above. The term "heteroaryloxycarbonyl" means an acyl radical derived from a carboxylic acid represented by heteroaryl- O-COOH wherein heteroaryl has the significance given above. The term "aminocarbonyl" alone or in combination, means an amino-substituted carbonyl (carba oyl) group derived from an amino-substituted carboxylic acid wherein the amino group can be a primary, secondary or tertiary amino group containing substituents selected from hydrogen, and alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl radicals and the like. The term "aminoalkanoyl" means an acyl group derived from an amino-substituted alkanecarboxylic acid wherein the amino group can be a primary, secondary or tertiary amino group containing substituents selected from hydrogen, and alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl radicals and the like. The term "halogen" means fluorine, chlorine, bromine or iodine. The. term "haloalkyl" means an alkyl radical having the significance as defined above wherein one or more hydrogens are replaced with a halogen. Examples of such haloalkyl radicals include chloromethyl, 1-bromoethyl, fluoromethyl, difluoromethyl, trifluoromethyl , 1, 1, 1-trifluoroethyl and the like. The term "leaving group" generally refers to groups readily displaceable by a nucleophile, such as an amine, a thiol or an alcohol nucleophile. Such leaving groups are well known in the art. Examples of such leaving groups include, but are not limited to, N-hydroxysuccinimide, N-hydroxybenzotriazole, halides, triflateε tosylates and the like. Preferred leaving groups are indicated herein where appropriate. Procedures for preparing the compounds of Formula I are set forth below. It should oe noted that the general procedure is shown as it relates to preparation of compoundε having the specified stereochemistry, for example, wherein the absolute stereochemistry about the hydroxyl group is designated as (R) , which is the preferred stereochemistry for the compounds of the present invention. However, such procedures are generally applicable to those compounds of opposite configuration, e.g., where the stereochemistry about the hydroxyl group is (S) . In addition, the compounds having the (R) stereochemistry can be utilized to produce those having the (S) stereochemistry. For example, a compound having the (R) stereochemistry can be inverted to the (S) stereochemistry using well-known methods. Preparation of Compounds of Formula T The compounds of the present invention represented by Formula I above can be prepared utilizing the following general procedure. This procedure is schematically shown in the following Schemes I and II: SCHEME I a) amine b) sulfamoyl chloride R R'NSO^Cl (or anhydride) + acid scavenger c) deprotection d) coupling e) ' coupling. SCHEME II a) amine b) sulfamoyl chloride (or anhydride! + acid scavenger c) deprotection d) coupling e) coupling. An N-protected chloroketone deri/ative of an amino acid having the formula: wherein P represents an amino protecting group, and R2 is as defined above, is reduced to the corresponding alcohol utilizing an appropriate reducing agent . Suitable amino protecting groups are well known in the art and include carbobenzoxy, t-butoxycarbonyl, and the like. A preferred amino protecting group is carbobenzoxy. A preferred N-protected chloroketone is N-benzyloxycarr>onyl-L- phenylalanine chloromethyl ketone. A preferred reducing agent is sodium borohydride. The reduction reaction is conducted at a temperature of from -10°C to about 25°C, preferably at about 0°C, in a suitable solvent system such as, for example, tetrahydrofuran, and the like. The N-protected chloroketones are commercially available, e.g., such as from Bachem, Inc., Torrance, California. Alternatively, the chloroketones can be prepared by the procedure set forth in S. J. Fittkau, J. Prakt . che .. 315. 1037 (1973) , and subsequently N-protected utilizing procedures which are well known in the art. The halo alcohol can be utilized directly, as described below, or, preferably, is then re-acted, preferably at room temperature, with a sui able base m a suitable solvent system to produce an N-prυtected amino epoxide of the formula: wherein P and R 2 are as defined above. Suitable solvent systems for preparing the amino epoxide include ethanol, methanol, isopropanol, tetrahydrofuran, dicxane, and the like including mixtures thereof. Suitable bases for producing the epoxide from the reduced chloroketone include potassium hydroxide, sodium hydroxide, potassium t-butoxide, DBU and the like. A preferred base is potassium hydroxide. Alternatively, a protected amino epoxide can be prepared starting with an L-amino acid which is reacted with a suitable amino-protecting group in a suitable solvent to produce an a ino-protected L-amino acid ester of the formula: wherein pl and p independently represent hydrogen, benzyl and amino-protecting groups (as defined above) , provided that p and P 2 are not both hydrogen; P 3 represents carboxyl-protecting group, e.g., methyl, ethyl, benzyl, tertiary-butyl and the like; and R is as defined above. The amino-protected L-amino acid ester is then reduced, to the corresponding alcohol. For example, the amino-protected L-amino acid ester can be reduced with diisobutylaluminum hydride at -78° C in a suitable solvent such as toluene. The resulting alcohol is then converted, for example, by way of a Swern oxidation, to the corresponding aldehyde of the formula: wherein P- 1 -, p and R2 are as defined above. Thus, a dichloromethane solution of the alcohol is added to a cooled (-75 to -68° C) solution of oxalyl chloride in dichloromethane and DMSO in dichloromethane and stirred for 35 minutes. The aldehyde resulting from the Swern oxidation is then reacted with a halomethyllithium reagent, which reagent is generated in situ by reacting an alkyllithium or arylithium compound with a dihalomethane represented by the formula wherein χ and X 2 independently represent I, Br or Cl. For example, a solxition of the aldehyde and chloroiodomethane in THF is cooled to -78° C and a solution of n-butyllithium in hexane is added. The resulting product is a mixture of diastereomers of the corresponding amino-protected epoxides of the formulas: The diastereomers can be separated e.g., by chromatography, or, alternatively, once reacted in subsequent steps the diastereomeric products can be separated. For compounds having the (S) stereochemistry, a D-amino acid can be utilized in place of the L-amino acid. The amino epoxide is then reacted, in a suitable solvent system, with an equal amount, or preferably an excess of, a desired amine of the formula: wherein R3 is hydrogen or is as defined above. The reaction can be conducted over a wide range of temperatures, e.g., from about 10°C to about 100°C, but is preferably, but not necessarily, conducted at a temperature at which the solvent begins to reflux. Suitable solvent systems include protic, non-protic and dipolar aprotic organic solvents such as, for example, those wherein the solvent is an alcohol, such as methanol, ethanol, isopropanol, and the like, ethers such as tetrahydrofuran, dioxaηe and the like, and toluene, N,N-dimethylformamide, dimethyl sulfoxide, and mixtures thereof. A preferred solvent is isopropanol. Exemplary amines corresponding to the formula R3NH2 include benzyl amine, isobutylamine, n-butyl amine, isopentyl amine, isoamylamine, cyclohexanemethyl amine, naphtnylene methyl amine and the like. The resulting product is a 3-(N- protected amino) -3- (R 2 ) -1- (NHR3) -propan-2-cl derivative (hereinafter referred to as an amino alcohol) can be represented by the formulas: wherein P, pl, P 2 » R2 and R are as described above. Alternatively, a haloalcohol can be utilized in place of the amino epoxide. The amino alcohol defined above is then reacted in a suitable solvent with a sulfamoyl halide, e.g. sulfamoyl chloride (R4R5NS02C1 or R 4 HNS02Ci) or sulfamoyl anhydride in the presence of an acid scavenger. Suitable solvents in which the reaction can be conducted include methylene chloride, tetrahydrofuran. Suitable acid scavengers include triethylamine, pyridine. The resulting sulfamic acid derivative can be represented, depending on the epoxide utilized, by the formulas; wherein P, pl, P 2 , R 2 , R 3 , R4 and R 5 are as defined above. These intermediates are useful for preparing inhibitor compounds of the present invention and are also active inhibitors of retroviral proteases. The sulfamoyl halides of the formula R 4 NHS02X can be prepared by the reaction of a suitable isocyanate of the formula R 4 NCO with fuming sulfuric acid to produce the corresponding sulfamate which is then converted to the halide by well known procedureε, such as by treating the sulfamate with PCI5. Alternatively the isocyanate can be treated with chlorosulfonic acid to produce the corresponding sulfamoyl chloride directly. The sulfamoyl halides of the formula R 4 R 5 NS02C1 can be prepared by reacting an amine of the formula R 4 R5 H, preferably as a salt such as the hydrochloride, with sulfuryl chloride in a suitable solvent such as acetonitrile. The reaction mixture is gradually warmed to reflux temperature and maintained at the reflux temperature until the reaction is complete. Alternatively, sulfamoyl halides of the formula R^R S02C1 can be prepared by reacting an amine of the fo ula R^R-^NH with sulfuryl chloride in boiling MeCN as disclosed in Matier et al., ~. Me . Che .. 1 , No. 5, p.538 (1972). Following preparation of the sulfamic acid derivative, the amino protecting group P or pl and P 2 amino protecting groups are removed under conditions which will not affect the remaining portion of the molecule. These methods are well known in the art and include acid hydrolysis, hydrogenolysis and the like. A preferred method involves removal of the protecting group, e.g., removal of a carbobenzoxy group, by hydrogenolysiε utilizing palladium on carbon in a suitable solvent system such as an alcohol, acetic acid, and the like or mixtures thereof. Where the protecting group is a t-butoxycarbonyl group, it can be removed utilizing an inorganic or organic acid, e.g., HC1 or trifluoroacetic acid, in a suitable solvent system, e.g., dioxane or methylene chloride. The resulting product is the amine salt derivative. Following neutralization of the salt, the amine is then reacted with an amino acid or corresponding derivative thereof represented by the formula (PN[CRl' Rl"]t CH(Rl)COOH) wherein t, Rl, pl ' and p " are as defined above, to produce the antiviral compounds of the present invention having the formula: wherein t, P, Rl, R ' , Rl", R 2 , R3, R 4 and 5 are as defined above. Preferred protecting groups in this instance are a benzyioxycarbonyl group or a t-butoxycarbonyl group. Where the amine is reacted with a derivative of an amino acid, e.g., when t=l and l' and Rl" are both H, so that the amino acid is a β-amino acid, such β-amino acids can be prepared according to the procedure set forth in a copending application, U. S. Serial No. 07/345,808. Where t is 1, one of Rl' and Rl" is H and Rl is hydrogen so that the amino acid is a homo- β-amino acid, such homo-β-amino acids can be prepared by the procedure set forth in a copending application, U.S. Serial No. 07/853,561. Where t is 0 and R is alkyl, alkenyl, alkynyl, cycloalkyl, -CH2SO2NH2, -CH2CO2CH3, -CO 2 CH 3 , -CONH 2 , -CH 2 C(0)NHCH 3 , -C(CH,) 2 (SH) , -C(CH 3 ) 2 (SCH 3 ) , -C(CH 3 ) 2 [S(0)CH 3 ] , -C(CH 3 )2IS(0 )CH 3 ] , or an amino acid side chain, such materials are well known and many are commercially available from Sigma-Aidrich. The N-protecting group can be subsequently removed, if desired, utilizing the procedures described above, and then reacted with a carboxylate represented by the formula: O II R—C—L wherein R is as defined above and L is an appropriate leaving group such as a halide. Preferably, where Rl is a side chain of a naturally occurring α-amino acid, R is a 2-quinoline carbonyl group derived from N-hydroxysuccinimide-2-quinoline carboxylate, i.e., L is hydroxy succinimide. A solution of the free amine (or amine acetate salt) and about 1.0 equivalent of the carboxylate are mixed in an appropriate solvent system and optionally treated with up to five equivalents of a base such as, for example, N-methylmorpholine, at about room temperature. Appropriate solvent systems include tetrahydrofuran, methylene chloride or N,N- dimethylformamide, and the like, including mixtures thereof. Alternatively, the protected amino alcohol from the epoxide opening can be further protected at the newly introduced amino group with a protecting group P' which is not removed when the first protecting P is removed. One skilled in the art can choose appropriate combinations of P and P' . One suitable choice is when P i_. Cbz and P' is Boc. The resulting compound represented by the formula: can be carried through the remainder of the synthesis to provide a compound of the formula: and the new protecting group P' is selectively removed, and following deprotection, the resulting amine reacted to form the sulfamic acid derivative as described above. This selective deprotection and conversion to the sulfamic acid can be accomplished at either the end of the synthesis or at any appropriate intermediate step if desired. It is contemplated that for preparing compounds of the Formulas having R6, the compounds can be prepared following the procedure set forth above and, prior to coupling the sulfonamide derivative or analog thereof, e.g. coupling to the amino acid PNH1CH2)tCH(Rl)COOH, carried through a procedure referred to in the art as reductive animation. Thus, a sodium cyanoborohydride and an appropriate aldehyde or ketone can be reacted with the sulfonamide derivative compound or appropriate analog at room temperature in order to reductively a inate any of the compounds of Formulas I-IV. It is also contemplated that where R3 of the amino alcohol intermediate is hydrogen, the inhibitor compounds of the present invention wherein R3 is alkyl, or other substituents wherein the α-C contains at least one hydrogen, can be prepared through reductive animation of the final product of the reaction between the amino alcohol and the amine or at any other stage of the synthesis for preparing the inhibitor compounds. Contemplated equivalents of the general formulas set forth above for the antiviral compounds and derivatives as well as the intermediates are compounds otherwise corresponding thereto and having the same general properties, such as tautomers there 'Ξ as well as compounds, wherein one or more of the various R groups are simple variations of the substituents as defined therein, e.g., wherein R is a higher alkyl group than that indicated. In addition, where a substitue.it is designated as, or can be, a hydrogen, the exact chemical nature of a substituent which is other than hydrogen at that position, e.g., a hydrocarbyl radical or a halogen, hydroxy, amino and the like functional group, is not critical so long as it does not adversely affect the overall activity and/or synthesis procedure. The chemical reactions described above are generally disclosed in terms of their broadest application to the preparation of the compounds of this invention. Occasionally, the reactions may not be applicable as described to each compound included within the disclosed scope. The compounds for which this occurs will be readily recognized by those skilled in the art. In all such cases, either the reactions can be successfully performed by conventional modifications known to those skilled in the art, e.g., by appropriate protection of interfering groups, by changing to alternative conventional reagents, by routine modification of reaction conditions, and the like, or other reactions disclosed herein or otherwise conventional, will be applicable to the preparation of the corresponding compounds of this invention. In all preparative methods, all starting materials are known or readily preparable from known starting materials. Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever. The following Examples 1 through 9 illustrate preparation of intermediates. These intermediates are useful in preparing the inhibitor compounds of the present invention as illustrated in Examples 13-17. In addition, the intermediates of Examples 4-9 are also retroviral protease inhibitors and inhibit, in particular, HIV protease. Example 1 Preparation of Nf3 I S ) -benzvloxvcarbonvlamino-2 (R) - hvdroxv-4-phenvlbutvll-N-isoamvlaπ-ine Part A: To a solution of 75.Og (0.226 mol) of N-benzyloxycarbonyl-L-phenylalanine chloromethyl ketone in a mixture of 807 mL of methanol and 807 mL of tetrahydrofuran at -2°C, was added 13.17g (0.348 mol, 1.54 equiv.) of solid sodium borohydride over one hundred minutes. The solvents were removed under reduced pressure at 40°C and the residue dissolved in ethyl acetate (approx. ID . The solution was washed sequentially with 1M potassium hydrogen sulfate, saturated sodium bicarbonate and then saturated sodium chloride solutions. After drying over anhydrous magnesium sulfate and filtering, the solution was removed under reduced pressure. To the resulting oil was added hexane (approx. ID and the mixture warmed to 60°C with swirling. After cooling to room temperature, the solids were collected and washed with 2L of hexane. The resulting solid was recrystallized from hot ethyl acetate and hexane to afford 32.3g (43% yield) of N-benzyloxycarbonyl-3 (S) -amino-l-chloro-4-phenyl-2 (S) - butanol, mp 150-151°C and M+Li+ = 340. Part B: To a solution of 6.52g (0.116 mol, 1.2 equiv.) of potassium hydroxide in 968 mL of absolute ethanol at room temperature, was added 32.3g (0.097 mol) of N-CBZ- 3 (S) -amino-l-chloro-4-phenyl-2 (S) -butanol. After stirring for fifteen minutes, the solvent was removed under reduced pressure and the solids dissolved in methylene chloride. After washing with water, drying over magnesium sulfate, filtering and stripping, one obtains 27.9g of a white solid. Recrystallization from hot ethyl acetate and hexane afforded 22.3g (77% yield) of N-benzyloxycarbonyl-3 (S) -amino-1,2 (S) -epoxy-4- phenylbutane, mp 102-103°C and MH+ 298. Part Ct A solution of .N-benzyloxycarbonyl (S) -amino- 1, 2- (S) -epoxy-4-phenylbutane (l.OOg, 3.36 mmol) and isoamylamine (4.90g, 67.2 mmol, 20 equiv.) in 10 mL of isopropyl alcohol was heated to reflux for 1.5 hours. The solution was cooled to room temperature, concentrated in vacuo and then poured into 100 mL of εtirring hexane whereupon the product crystallized from solution. The product was isolated by filtration and air dried to give 1.18g, 95% of N=[ [3 (S) -phenylmethylcarbamoyl) amino-2 (R) - hydroxy-4-phenylbutyl]N- [ (3-methylbutyl) ]amine mp 108.0- 109.5°C, MH+ m/z = 371. Example 2 Preparation of N.N-dibenzvl- (S) -amino-1.2- fs) -epoxv-4- Step A: A solution of L-phenylalanine (50.0 g, 0.302 mol), sodium hydroxide (24.2 g, 0.605 mol) and potassium carbonate (83.6 g, 0.605 mol) in water (500 ml) is heated to 97°C. Benzyl bromide (108.5 ml, 0.912 mol) is then slowly added (addition time -25 min) . The mixture is then stirred at 97°C for 30 minutes. The solution is cooled to room temperature and extracted with toluene (2 x 250 ml) . The combined organic layers are then washed with water, brine, dried over magnesium sulfate, filtered and concentrated to give an oil product. The crude product is then used in the next step without purification. Step B: The crude benzylated product of the above step is dissolved in toluene (750 ml) and cooled to -55° . A 1.5 M solution of DIBAL-H in toluene (443.9 ml, 0.666 mol) is then added at a rate to maintain the temperature between -55° to -50°C (addition time - 1 hour) . The mixture is stirred for 20 minutes at -55°C. The reaction is quenched at -55°C by the slow addition of methanol (37 ml) . The cold solution is then poured into cold (5°C) 1.5 N HC1 solution (1.8 L) . The precipitated solid (approx. 138 g) is filtered off and washed with toluene. The solid material is suspended in a mixture of toluene (400 ml) and water (100 ml) . The mixture is cooled to 5°C, treated with 2.5 N NaOH (186 ml) and then stirred at room temperature until the solid is dissolved The toluene layer is separated from the aqueous phase and washed with water and brine, dried over magnesium sulfate, filtered and concentrated to a volume of 75 ml (89 g) . Ethyl acetate (25 ml) and hexane (25 ml) are then added to the residue upon which the alcohol product begins to crystallize. After 30 min., an additional 50 ml hexane is added to promote further crystallization. The solid is filtered off and washed with 50 ml hexane to give approximately 35 g of material. A second crop of matrial can be isolated by refiltering the mother liquor. The solids are combined and recrystallized from ethyl acetate (20 ml) and hexane (30 ml) to give, in 2 crops, approximately 40 g (40% from L-phenylalanine) of analytically pure alcohol product. The mother liquors are combined and concentrated (34 g) . The residue is treated with ethyl acetate and hexane which provides an additional 7 g (-7% yield) of slightly impure solid product. Further optimization in the recovery from the mother liquor is probable. Step C: A solution of oxalyl chloride (8.4 ml, 0.096 mol) in dichloromethane (240 ml) is cooled to -74°C. A solution of DMSO (12.0 ml, 0.155 mol) in dichloromethane (50 ml) is then slowly added at a rate to maintain the temperature at -74°C (addition time -1.25 hr) . The mixture is stirred for 5 min. followed by addition of a solution of the alcohol (0.074 mol) in 100 mi of dichloromethane (addition time -20 min., temp. -75°C to -68°C) . The solution is stirred at -78°C for 35 minutes. Triethylamine (41.2 ml, 0.295 mol) is then added over 10 min. (temp. -78° to -68°C) upon which the ammonium salt precipitated. The cold mixture is stirred for 30 min. and then water (225 ml) is added. The dichloromethane layer is separated from the aqueous phase and washed with water, brine, dried over magnesium sulfate, filtered and concentrated. The residue is diluted with ethyl acetate and hexane and then filtered to further remove the ammonium salt. The filtrate is concentrated to give the desired aldehyde product. The aldehyde was carried on to the next step without purification. Temperatures higher than -70°C navv been reported in the literature for the Swern oxidation. Other Swern modifications and alternatives to the Swern oxidations are also possible. A solution of the crude aldehyde 0.074 mol and chloroiodomethane (7.0 ml, 0.096 mol) in tetrahydrofuran (285 ml) is cooled to -78°C. A 1.6 M solution of n-butyllithium in hexane (25 ml, 0.040 mol) is then added at a rate to maintain the temperature at -75°C (addition time - 15 min. ) . After the first addition, additional chloroiodomethane (1.6 ml, 0.022 mol) is added again, followed by n-butyllithium (23 ml, 0.037 mcl) , keeping the temperature at -75°C. The mixture is stirred for 15 min. Each of the reagents, chloroiodomethane (0.70 ml, 0.010 mol) and n-butyllithium (5 ml, 0.008 mcl) are added 4 more times over 45 min. at -75°C. The cooling bath is then removed and the solution warmed to 22°C over 1.5 hr. The mixture is poured into 300 ml of saturated aq. ammonium chloride solution. The tetrahydrofuran layer is separated. The aqueous phase is extracted with ethyl acetate (1 x 300 ml) . The combined organic layers are washed with brine, dried over magnesium sulfate, filtered and concentrated to give a b rown oil (27.4 g) . The product could be used in the next step without purification. The desired diastereomer can be purified by recrystallization at a subsequent step. Alternately, the product could be purified by chromatography. Exam le Preparation of NT3 (S) -benzyloxycarbonylamino-2 (R) -hvdroxy-4- phenyllN-isobutylamine • A solution of N-benzyloxycarbonyl-3 (S) -amino- 1,2- (S) -epoxy-4-phenyl butane (50.0 g, 0.168 mol) and isobutylamine (246 g, 3.24 mol, 20 equivalents) in 650 mL of iεopropyl alcohol was heated to reflux for 1.25 hours. The εolution was cooled to room temperature, concentrated in vacuo and then poured into 1 L of εtirring hexane whereupon the product cryεtallized from εolution. The product waε isolated by filtration and air dried to give 57.56 g, 92% of N[3 (S) -benzyloxycarbonylamino-2 (R) - hyd ' roxy-4-phenyl]N-iεobutylamine, mp 108.0-109.5 * C, MH+ m/z=371. Example 4 Preparation of phenylmethyl r2R-hvdroxy-3- r f (dimethvlamino) sulfonvll (2-methvlpropvl) mino1 -1S- (phenvlmethvl)propvl1 carbamate The product from Example 3 (740 mg, 2.0 mmol) and diisopropylethylamme (382 uL, 2.2 mmol) were dissolved in dichloromethane (1.5 mL) at room temperature. To this was added dimethylsulfamoyl chloride (354 uL, 3.3 mmol). The reaction was stirred for 24 hours. The reaction mixture was chromatographed on silica gel (50 gm) using 1% ethanol in chloroform. The product fractions were pooled and concentrated to an oil. Anal. Calcd for C 24 H 3 -.N 3 0 5 S: C, 60.35; H, 7.39; N, 8.80. Found: C, 60.18; H, 7.40; N, 8.55. Example 5 Preparation of phenvlmethvlr2R-hvdroxv-3- f f (dimethvlamino)sulfonvll (3-methvlbutvl)amino1 -1S- (phenvlmethvl)propvll carbamate Part A The procedure described in Example 1 was used to prepare N[3 (S) -benzyloxycarbonylamino-2 (R) -hydroxy-4- phenylbuty1] -N- [ (3-methylbuty1) ]amine. Part B The product from Part A (192 mg, u.5 mmol) and diisopropylethylamme (96 uL, 0.55 mmol) were dissolved in dichloromethane (10 mL) at room temperature. To this waε added dimethylsulfamoyl chloride (59 uL, 0.55 mmol). The reaction was stirred for 120 hours, then concentrated on a rotary evaporator. The residue was chromatographed on silica gel (50 gm) using 2% methanol in dichloromethane. The product fractions were pooled and concentrated to an oil which solidified on standing. Anal. Calcd for C 25 H 37 3 0-.S. 0.9 H 2 0: C, 59.13; H, 7.64; N, 8.27; S, 6.31. Found: C, 58.81; H, 7.38; N, 8.62; S, 6.70. Example 6 Preparation of phenvlmethvl T3-r f (butvlamino)sulfonvll (2- methvlpropvl)amino1-2R-hvdroxv-lS- (phenvlmethvl)propvll arkama e Part A: To a stirred solution of 3.88 gm (2 mL) of 30% fuming sulfuric acid in nitromethane (lOmL) was added dropwise n-butylisocyanate (3.83 mL, 34 mmoles) at 0 C. After the addition was completed, the suspension was heated in an oil bath at 120 C. for 30 min. The reaction was cooled and filtered. The collected sulfamic acid crystals were air dried, wt. 4.73 gm (91%). Par β: A suspension of n-butyl sulfami', acid (1.92 gm, 12.53 mmoles) and phosphoruε pentachloride i.61 gm, 12.53 mmoles) in benzene (20 mL) was warmed gently to initiate gaε evolution. The reaction mixture was stirred at room temperature for 0.5 h. , during which time a cloudy εolution resulted.The cloudy solution was heated to reflux for 0.5 h. , then was concentrated. The product n-butyl sulfamoyl chloride was isolated by vacuum distillation (120 C, 300 millitorr) , 730 mg (liq.) (34%). Part C : The amine alcohol from Example 3 (370 mg, 1 mmole) was dissolved in 3 mL of dichloromethane and treated with diisopropylethylamme (278 uL, 2 mmoles), followed by chlorotrimethylsilane (126 uL, 1 mmole) . The reaction mixture was εtirred at r.t. for 1 h. n-Butyl sulfamoyl chloride from Part B (171 mg, 1 mmole) was added and the mixture was stirred at r.t. overnight. After removal of dichloromethane the oily residue was taken up in ethyl acetate and washed successively with 5% citric acid, saturated sodium bicarbonate, brine, dried over sodium sulfate and the solvent was evaporated to give 512 mg of product (oil) . The oily product (510 mg) was dissolved in dichloromethane (3 mL) and was treated with 2 mL of 4N HCl in dioxane. After 15 min. methanol (5 mL) was added and the solution was stirred for an additional 15 min Solvent and exceεε reagent were evaporated. The product waε isolated by silica gel chromatography to give 357 mg of phenylmethyl [3- [ [ (butylamino) sulfonyl] (2-methylpropyl)amino] -2R-hydroxy-lS- (phenylmethyl)propyl] carbamate. Anal. Calcd for C26H39N3O5S: C, 61.76; H,7.77; N,8.31. Found: C, 61.89; H,7.66; N, 8.18. gxflTO3-e 7 Preparation of phenvlmethvl . 2R-hvdroxv-3 - . I ( 4-methvl-l - n_ .-razinvl . __ulf.-nvn ( 2-methvlproPvl ) aminol - 1S- (phenvlmethvl ) propvn carbamate Pajrt A 1-methylpiperazine hydrochloride (3.46 gm, 20 mmoles) was added in portions within 15 mir:. to a stirred solution of sulfuryl chloride (8.99 gm, 67 mmoles) in acetonitrile(40 mL) . The suspension was gradually warmed to reflux and maintained at reflux temperature overnight. A brown solution was obtained. After cooling to r.t., the crystals were collected by filtration, wt. 2.3 gm. A sample of 4-methyl-l-piperazine sulfamoyl chloride.HCl was recrystallized from methanol. Anal. Calcd. for C5H12N2O2CI2S: C, 25.54; H, 5.14; N, 11.9?; Cl, 30.16. Found: C, 25.54; H, 4.91; N, 11.91; Cl, 29.88. Part B: N[3 (S) -benzyloxycarbonylamino-2 (R)-hydroxy-4- phenylbutyl]-N-isobutylamine (370 mg, 1.0 mmole), prepared according to the procedure in Example 3 was mixed with DIEA (280 uL, 2.0 mmoles) and 4-methyl-l-piperazine sulfamoyl chloride.HCl (240 mg, 1.0 mmole) in 6 mL of dichloromethane. The reaction mixture was stirred for 5 days. After filtration, the filtrate was concentrated r o an oil, which waε taken up in ethyl acetate. The ethyl acetate solution waε washed with sodium bicarbonate solution, brine and dried over εodium εulfate. After evaporation, phenylmethyl [2R- hydroxy-3-[[ (4-methyl-l-piperazinyl) εulfonyl] (2- methylpropyl)amino] -IS- (phenylmethyl)propyl] carbamate waε obtained (412 mg) . Example 8 Preparation of phenvlmethvl r2R-hvdroxv-3- T \ H. - dimethyl) amino1 sulfonvll (2-m hvlpropvl) minoi -1S- (phenvlmethvl)propvl] carbamate Part A: A 25 mL two-necked RB flaεk, equipped with a reflux condenser and dropping funnel and under a nitrogen atmosphere, was charged with t-butanol (207 uL, 2.2 mmoles) and 5 mL of hexane. Chlorosulfonyi isocyanate (192 uL, 2.2 mmoles) in 3 mL of hexane was added dropwise. Upon warming a ho ogeneouε εolution waε obtaine '. The εolution waε heated at gentle reflux for 45 min., t<;en waε cooled to r.t. Solvent waε removed under a εteady εtream of nitrogen. The crude t-butyl εulfamoyl chloride (a liquid) was uεed without further purification. Part B : N[3 (S) -benzyloxycarbonylamino-2 (R) -hydroxy-4- phenylbutyl] -N-isobutylamine (370 mg, 1.0 mmole), prepared according to the procedure in Example 3 waε mixed with DIEA (139 uL, 1 mmole) in 5 mL of dichloromethane. Chlorotrimethylsilane (126 uL, 1 mmole) was added. After 1 h., additional DIEA (160 uL) was added, followed by a dichloromethane solution (5mL) containing 1.1 mmole of t-butyl sulfamoyl chloride from Part A. The reaction mixture waε stirred for 2 days. Solvent waε removed under aεpirator pressure. The oily residue was taken up in ethyl acetate and washed with 5% citric acid, saturated sodium bicarbonate, brine, dried over sodium sulfate and evaporated to an oily residue (380 mg) . The crude product was stirred in 4N HCl in dioxane (6 mL) for 15 min. After the addition of 4 mL of methanol to the reaction mixture, the solution was stirred for an additional 15 min, then concentrateo to an oily residue. The product, phenylmethyl [2R-hydroxy -3-[[(l,l- dimethylethy1)amino] sulfonyl] (2-methylpropyl)amino] -1S- (phenylmethyl)propyl] carbamate was obtained after silica gel chromatography (188 mg, 37%) . MS ( MH)+ = 506. Example 9 Preparation of phenylmethyl r2R-hvdroxy-3- rr (pjperidyl) sulfonyll (2-methylpropyl) aminol -1S- (phenylmethyl)propyl1 carbamate Part A: The product of Example 3 (750 mg . 2.02 mmol) and triethylamine (280 uL, 2.02 mmol) were dissolved in dichloromethane (8.0 mL) at room temperature. To this was added piperidinesulfamoyl chloride (371 mg, 2.02 mmol) . The reaction was stirred for 72 hours and then concentrated. The residue was chromatographed on silica gel (50 gm) using 5% methanol in dichloromethane. The product fractions were pooled and concentrated to an oil, 945 mg. TLC (silica / 5% MeOH in CH2C12) showed two spotε. Rechromatographed. Anal. Calcd for C27H39N305S: C, 62.63; H, 7.51; N, 8.06. Found: C, 62.64; H, 7.59; N, 8.12. Part B: The product of Part A (430 mg) waε combined with 10% Pd/C in methanol (10 mL) and hydrogenared at 5 pεi for 1.4 hours at room temperature. The catalyst was removed by filtration and the solvent evaporated to afford the product as an oil, 305 mg. Part C; To a εolution of Cbz-L-t-leucine (236 mg, 0.89 mmol) in DMF (2 mL) was added HOBt (115 mg, 0.85 mmol) and EDC (163 mg, 0.85 mmol) . The reaction was stirred at room temperature for 1 hour and then a solution of the product from part B (305 mg, 0.79 mmol) in DMF (2 ;rιL) waε added. The reaction waε stirred for 18 hours then concentrated. The residue was taken up in ethyl acetate and washed with 0.5% HCl εolution, saturated aqueous NaHCO " . , and saturated aqueous NaCl (50 mL each) . The organic solution was dried (Na2S04), filtered and concentrated to a foam, 410 mg. IH NMR supportε product. Part D : The product of Part C (410 mg) was combined with 10% Pd/C in methanol (10 mL) and hydrogenated at 5 psi for 2.0 hours at room temperature. The catalyεt waε removed by filtration and the solvent evaporated to afford the product as an foam, 320 mg. Part E: To a εolution of the product of Part D (310 mg, 0.62 mmol) in dichloromethane (10 mL) waε added diisopropylethylamine (130 uL, 0.75 mmol) and chloroacetic anhydride (117 mg, 0.68 mmol) at 0 C. The reaction was allowed to warm to room temperature and stir one hour. The solvent was removed and the residue taken up in ethyl acetate (50 mL) . The organic solution was washed with 5% citric acid, saturated NaHC03, and saturated NaCl (50 mL each) . The solution waε dried (Na2S04) , filtered and concentrated to give a solid, 350 mg. Part F; The product of Part E (350 mg, 0.61 mmol) was combined with 40% aqueous dimethylamine (380 uL, 3.05 mmol) in isopropanol (10 mL) . The reaction was stirred for 18 hours then concentrated. The residue was taken up in ethyl acetate (50 mL) and washed with water, saturated NaHC03, an saturated NaCl (50 mL each) . The solution was dried (Na2S04) , filtered and concentrated to a solid. The εolid waε chromatographed on εilica gel using 2% MeOH in dichloromethane. The product fracticnε were pooled and concentrated to give a white εolid. Anal. Calcd for C29H51N505S. 0.25 H20: C, 59.41; H, 8.77; rt, 11.94. Found: C, 59.35; H, 8.78; N, 11.63. Example 10 Following the procedures of the previous Examples 1-9, the intermediate compounds set forth in Tables 1A, IB and IC were prepared. TABLE 1A isobutyl CH- CH 3 isoamyl CH, CH, isobutyl CH2CH2CH2CH3 H isobutyl C(CH3)3 H TABLE IB Entry R4 1 CH, CH. 2 3 4 5 6 7 The following Examples 11-13 illustrate preparation of β-amino acid intermediates. These intermediates can be coupled to the intermediate compounds of Examples 1-10 to produce inhibitor compounds of the present invention containing β-amino acids. Example 11 A. Preparation of 4 (4-methoxybenzyl)itaconate A 5 L three-necked round bottomed flask equipped with constant pressure addition funnel, reflux condenser, nitrogen inlet, and mechanical stirrer waε charged with itaconic anhydride (660.8g, 5.88 mol) and toluene (2300 mL) . The solution was warmed to reflux and treated with 4-methoxybenzyl alcohol (812.4g, 5.88 mol) dropwise over a 2.6h period. The solution was maintained at reflux for an additional 1.5h and then the contents were poured into three 2 L erlenmeyer flasks to cryεtallize. The solution was allowed to cool to room temperature whereupon the desired mono-ester crystallized. The product was isolated by filtration on a Buchner funnel and air dried to give 850.2g, 58% of material with mp 83-85°C, a second crop, 17% was isolated after cooling of the filtrate in an ice bath. 1H NMR (CDCI3) 300 MHz 7.32(d, J=8.7 Hz, 2H) , 6.91(d, J=8.7 Hz, 2H) , 6.49(s, IH) , 5.85(s, IH) , 5.12(ε, 2H) , 3.83(ε, 3H) , 3.40(ε, 2H) . B . Preparation of Methyl 4 ( 4-methoxybenzyl ) itaconate A 5 L three-necked round bottomed flask equipped with reflux condenser, nitrogen inlet, constant pressure addition funnel and mechanical stirrer waε charged with 4 (4-methoxybenzyl) itaconate (453.4g, 1.81 mol) and treated with 1, 5-diazabicyclo[4.3.0]non-5-ene (275.6g, 1.81 mol), (DBN) , dropwiεe εo that the temperature did not rise above 15°C. To this stirring mixture was added a solution of methyl iodide (256.9g, 1.81 mol) in 250 mL of toluene from the dropping funnel over a 45m period. The solution was allowed to warm to room temperature and stirred for an additional 3.25h. The precipitated DBN hydroiodide was removed by filtration, washed with toluene and the filtrate poured into a εeparatory funnel. The εolution waε washed with sat. aq. NaHC03 (2 X 500 mL) , 0.2N HCl (1 X 500 mL) , and brine (2 X 500 mL) , dried over anhyd. MgS04, filtered, and the solvent removed in vacuo. This gave a clear colorless oil, 450.2g, 94% whose NMR waε consistent with the aεεigned structure. 1H NMR (CDCI3) 300 MHz 7.30 (d, J=8.7 Hz, 2H) , 6.90(d, J=8.7 Hz, 2H) , 6.34is, IH) , 5.71(ε, IH) , 5.09(ε, 2H) , 3.82(ε, 3H) , 3.73(ε, 3H) , 3.38(s, 2H) . 13c NMR (CDCI3) 170.46, 166.47, 159.51, 133.55, 129.97, 128.45, 127.72, 113.77, 66.36, 55.12, 51.94, 37.64. C. Preparation of Methyl 4 (4-methoxybenzyl) 2 (R) - methylsuccinate A 500 mL Fisher-Porter bottle was charged with methyl 4 (4-methoxybenzyl) itaconate (71.lg, 0.269 mol), rhodium (R,R) DiPAMP catalyst (204mg, 0.269 mmol, 0.1 mol%) and degassed methanol (215 mL) . The bottle was flushed 5 times with nitrogen and 5 times with hydrogen to a final pressure of 40 psig. The hydrogenation commenced immediately and after ca. lh the uptake began to taper off, after 3h the hydrogen uptake ceased and the bottle was flushed with nitrogen, opened and the contents concentrated on a rotary evaporator to give a brown oil that was taken up in boiling iso-octane (ca. 200 mL, this waε repeated twice) , filtered through a pad of celite and the filtrate concentrated in vacuo to give 66.6g, 93% of a clear colorless oil, 1H NMR (CDCI3 300 MHz 7.30(d, J=8.7 Hz, 2H) , 6.91(d, J=8.7 Hz, 2H) , 5.08(s, 2H) , 3.82(ε, 3H) , 3.67(ε, 3H) , 2.95(ddq, J=5.7, 7.5, 8.7 Hz, IH) , 2.79(dd, J=8.1, 16.5 Hz, IH) , 2.45(dd, J=5.7, 16.5 Hz, IH) , 1.23 (d, J=7.5 Hz, 3H) . D. Preparation of Methyl 2 (R)-methylεuccinate A 3 L three-necked round-bottomed flask equipped with a nitrogen inlet, mechanical stirrer, reflux condenser and constant pressure addition funnel was charged with methyl 4 (4-methoxybenzyl) 2(R)- methylsuccinate (432.6g, 1.65 mol) and toluene (1200 mL) . The stirrer was started and the solution treated with trifluoroacetic acid (600 mL) from the dropping funnel over 0.25h. The solution turned a deep purple color and the internal temperature rose to 45°C. After stirring for 2.25h the temperature was 27°C and the solution had acquired a pink color. The solution was concentrated on a rotary evaporator. The residue was diluted with water (2200 mL) and sat. aq. NaHCθ3 (1000 mL) . Additional NaHC03 was added until the acid had been neutralized. The aqueous phase was extracted with ethyl acetate (2 X 1000 mL) to remove the by-products and the aqueous layer was acidified to pH=1.8 with cone. HCl. This solution was extracted with ethyl acetate (4 X 1000 mL) , washed with brine, dried over anhyd. MgS04, filtered and concentrated on a rotary evaporator to give a colorless liquid 251g, >100% that was vacuum distilled through a short path apparatus cut 1: bath temperature 120°C @ >lmm, bp 25-2 °C; cut 2: bath temperature 140°C @ 0.5mm, bp 95-108°C, 151g, [α. d @ 25°C=+1.38°C(c=15. 75, MeOH) , [α] d =+8.48°C (neat); cut 3: bath temperature 140°C, bp 108°C, 36g, [o] d @ 25°C=+1.49°C(c=15.00, MeOK) , [o] d =+8.98°C (neat). Cuts 2 and 3 were combined to give 189g, 78% of product, 1H NMR (CDCI3) 300 MHz 11.6(brε, IH) , 3.72{s, 3H), 2.92(ddq, J=5.7, 6.9, 8.0 Hz, IH) , 2.81(dd, J=8.0, 16.8 Hz, IH) , 2.47(dd, J=5.7, 16.8 Hz, IH) , 1.26 (d, J=6.9 Hz, 3H) . Preparation of Methyl Itaconate A 50 mL round bottomed flask equipped with reflux condenser, nitrogen inlet and magnetic stir bar waε charged with methyl 4 (4-methoxybenzyl) itaconate (4.00g, 16 mmol), 12 mL of touluene and 6 mL of trifluoroacetic acid. The solution was kept at room temperature for 18 hours and then the volatiles were removed n vacuo. The residue was taken up in ethyl acetate and extracted three times with saturated aqueous sodium bicarbonate solution. The combined aqueous extract was acidified to pH=l with aqueous potassium bisulfate and then extracted three times with ethyl acetate. The combined ethyl acetate solution was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered, and concentrated -Lπ vacuo. The residue waε then vacuum distal 1 ed to give 1.23g, 75% of pure product, bp 85-87 @ 0.1 mm. 1H NMR (CDCI3) 300 MHz 6.34(ε, IH) , 5.73(ε, 2H) , 3.76(s, 3H) , 3.38(s, 2H) . 13c NMR (CDCI3) 177.03, 166.65, 129.220, 132.99, 52.27, 37.46. F. Curtiuε Rearrangement of Methyl 2 (R)-methylsuccinate: Preparation of Methyl N-Moz-α-methyl β-alanine. A 5L four necked round bottomed flask equipped with a nitrogen inlet, reflux condenser, mechanical stirrer, conεtant pressure addition funnel, and thermometer adapter was charged with methyl 2 (R) -methylsuccinate (184.lg, 1.26 mol), triethylamine (165.6g, 218 mL, 1.64 mol, 1.3 equivalents), and toluene (1063 mL) . The solution was warmed to 85°C and then treated dropwise with a solution of diphenylphosphoryl azide (346.8g, 1.26 mol) over a period of 1.2h. The εolution waε maintained at that temperature for an additional l.Oh and then the mixture waε treated with 4-methoxybenzyl alcohol (174.1g, 1.26 mol) over a 0.33h period from the dropping funnel. The solution was stirred at 88°C for an additional 2.25h and then cooled to room temperature. The contents of the flask were poured into a separatory funnel and washed with sat. aq. NaHC03 (2 X 500 mL) , 0.2N HCl (2 X 500 mL) , brine (1 X 500 mL) , dried over anhyd. MgS04, filtered, and concentrated n vacuo to give 302.3g, 85% of the desired product as a slightly brown oil. iH NMR (CDCI3) 300 MHz 7.32(d, J=8.4 Hz, 2H) , 6.91(d, J=8.4 Hz, 2H) , 5.2(brm, IH) , 5.05(ε, 2H), 3.83(ε, 3H) , 3.70(ε, 3H) , 3.35(m, 2H) , 2.70(m, 2H) , 1.20(d, J=7.2 Hz, 3H) . G. Hydrolysis of Methyl N-Moz-α-methyl β-alanine: Preparation of α-methyl β-alanine Hydrochicride A 5 L three-necked round bottomed flask equipped with a reflux condenser, nitrogen inlet and mechanical stirrer was charged with methyl N-Moz-α-methyl β-alanine (218.6g, 0.78 mol), glacial acetic acid (975 mL) and 12N hydrochloric acid (1960 mL) . The solution was then heated to reflux for 3h. After the solution had cooled to room temperature (ca. lh) the aqueous phase was decanted from organic residue (polymer) and the aqueous phase concentrated on a rotary evaporator. Upon addition of acetone to the concentrated residue a slightly yellow solid formed that was slurried with acetone and the white solid was isolated by filtration on a Buchner funnel. The last traces of acetone were removed by evacuation to give 97.7g, 90% of pure product, mp 128.5- . > ϋ .5°C [α] d @ 25°C=9.0°C (c=2.535, Methanol) . 1H NMR (D2O) 300 MHz 3.29(dd, J=8.6, 13.0 Hz, IH) , 3.16 (dd, J=5.0, 13.0m Hz, IH) , 2.94(ddq, J=7.2, 5.0, 8.6 Hz, IH) , 1.30(d,J=7.2 Hz, 3H); 13c NMR (D2θ) 180.84, 44.56, 40.27, 17.49. H. Preparation of N-Boc α-Methyl β-Alanine A solution of a-methyl b-alanine hydrochloride (97.7g, 0.70 mol) in water (1050 mL) and dioxane (1050 mL) the pH was adjusted to 8.9 with 2.9N NaOH solution. This stirring solution was then treated with di-tert- butyl pyrocarbonate (183.3g, 0.84 mol, 1.2 equivalents) all at once. The pH of the solution was maintained between 8.7 and 9.0 by the periodic addition of 2.5N NaOH solution. After 2.5h the pH had stabilized and the reaction was judged to be complete. The solution was concentrated on a rotary evaporator (the temperature was maintained at <40°C) . The excesε di-tert -butyl pyrocarbonate waε removed by extraction with dichloromethane and then the aqueouε solution was acidified with cold IN HCl and immediately extracted with ethyl acetate (4 X 1000 mL) . The combined etnyl acetate extract was washed with brine, dried over anhyd. MgS04, filtered and concentrated on a rotary evaporator to give a thick oil 127.3g, 90% crude yield that was stirred with n-hexane whereupon crystals of pure product formed, 95.65g, 67%, mp 76-78°C, [α] d @ 25°C=-11.8°C (c=2.4, EtOH) . A second crop was obtained by concentration of the filtrate and dilution with hexane, 15. g, for a combined yield of 111.05g, 78%. 1H NMR (acetone D6) 300 MHz 11.7 (brs, IH) , 6.05 (brs IH) , 3.35 (m, IH) , 3.22 ( , IH) , 2.50 (m, IH) , 1.45(ε, 9H) , 1.19 (d, J=7.3 Hz, 3H) ; 13c NMR (acetone D6) 177.01, 79.28, 44.44, 40.92, 29.08, 15.50. Elemental analysis calc'd. for C9H17NO4: C , 53 . 19 , H, 8 . 42 ; N, 6 . 89 . Found : C , 53 . 36 ; H, 8 . 46 ; N, 6 . 99 . I. Preparation of N-4-Methoxybenzyloxycarbonyl α-Methyl β-Alanine A solution of N-4-methoxybenzyloxycarbonyl α-methyl β-alanine methyl ester (2.81g, 10.0 mmol) in 30 mL of 25% aqueous methanol waε treated with lithium hydroxide (1.3 equivalentε) at room temperature for a period of 2h. The εolution was concentrated in vacuo and the reεidue taken up in a mixture of water and ether and the phases separated and the organic phase discarded. The aqueous phase was acidified with potassium hydrogen sulfate to pH=1.5 and then extracted chree timeε with ether. The combined ethereal phase was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give 2.60 g, 97% of N-4-Methoxybenzyloxycarbonyl α-methyl β-alanine (N-Moz-AMBA) which was purified by recrystallization from a mixture of ethyl acetate and hexane to give 2.44g, 91% of pure product, mp 96-97°C, MH+=268. 1H NMR (D6-acetone/300 MHz) 1.16 .3H, d, J=7.2Hz), 2.70 (IH. m) , 3.31 (2H, m) , 3.31 (3H, s) , 4.99 (2H, ε), 6.92 (2H, 4, J=8.7 Hz), 7.13 (2H, d, J=8.7 Hz) . Exam le 2 Following generally the procedure of Example , the β-amino acids set forth in Table 2 were prepared. Table 2 Entry R 1 R 1 ' R 1 ' Table 2 (Cont'd) Entry R 1 R 1 ' R 1 ' Example 13 Utilizing generally the procedure set forth in Example 11, the following β-amino acid compounds were prepared. Example 14 Preparation of N- .3- r f (butvlamino) sulfonvll (2- methvlpropvl)aminol -2R-hvdroxv-lS- (phenvlmethvl)propvll - 2S- f \2 - (dimethylamino) -1- oxoethyll aminoldimethylbutanamide Part A: The product from Example 3 (357 mg, 0.71 mmol) in 10 mL of methanol was hydrogenated over 10% palladium on carbon (60 mg) for 5 hr. The mixture was then filtered through Celite and concentrated to give the product as an oil (213 mg) . Part B: The free amine from Part A (210 mg, 0.566 mmol) was coupled with N-CBZ-L-t-butylglycine (180 mg, 0.679 mmol) in the presence of N-hydroxybenzotriazole (92 mg, 0.679 mmol) and EDC (130 mg, 0.679 mmol) to yield 275 mg of phenylmethyl [ [ [IS- [3- [ (butylamino) sulfonyl] (2- methylpropyl)amino] -2R-hydroxy-lS- (phenylmethyl)propyl] - amino] carbonyl] -2, 2-dimethylpropyl] carbamate after purification on silica column. Part C : The product from Part B (235 mg) in methanol was hydrogenated over 10% palladium on carbon (50 mg) for 4 h. The mixture was filtered through Celite and concentrated to give the product as an oil (173 mg, 0.369 mmol) . This free amine waε then disεolved in 3 mL of dichloromethane and acylated with bromo acetyl chloride (34 uL, 0.406 mmol) in the presence of DIEA (62 uL, 0.443 mmol) for 2 h. The crude mixture (190 mg, 0.32 mmol) waε diεεolved in 1 mL of isopropanol and mixed with a 40% wt dimethylamine in water (180 uL, 1.6 mmol) and stirred overnight. Solvent and excess reagents were evaporated. The oily residue was taken up in ethylacetate, washed with saturated sodium bicarbonate, brine and dried over sodium sulfate. The product N- [3- [ [ (butylamino)- sulfonyl] (2-methylpropyl)amino] -2R-hydroxy-lS- (phenylmethyl)propyl] -2S- [ [2- (dimethylamino) -1- oxoethyl]amino]3,3-dimethylbutanamide was purified by silica gel chromatography. Anal. Calc'd for C28 H 51 N 5°5 S - 0.5 H20: C, 58.10; H, 9.06; N, 12.09. Found: C, 57.81; H, 8.44; N, 12.01. El MS M+ = 569. Example 15 Preparation of Nl- r2R-hvdroxv-3- ( . (4-methvl-l- piperazinvDsulfonvll (2-methvlpropvl) aminol -IS- (phenvlmethvl)propvll -25,-f (2- σuinolinvlcarbonvl) aminolbutanediamide Part A: A solution of the carbamate from Example 7 (412 mg, 0.77 mmoleε) containing 20 mL methanol and 5 mL acetic acid waε hydrogenated over 10% palladium on carbon (80 mg) for 6 h. After filtration of the reaction mixture, the filtrate waε evaporated to an oil. The oily reεidue waε dissolved in ethyl acetate and with sodium bicarbonate solution. The organic layer was evaporated to give the free amine (100 mg) . Part B: The free amine from Part A (80 mg, 0.20 mmoleε) waε coupled with N-BOC-L-aεparagine (61 mg. 0.264 mmoleε) in the preεence of N-hydroxybenzotriazole (48mg, 0.35 mmoleε) and EDC (50 mg, 0.264 mmoleε) to yield 125 mg of Nl [2R-hydroxy -3- [3- [ (4-methyl-l-piperaziny) sulfonyl] (2- methylpropyl)amino] -IS- (phenylmethyl)propyi] ] -2S- [(1,1- dimethylethoxycarbonyl)amino]butane diamid . Part C : Nl[2R-hydroxy -3- [3- [ (4-methyl-l- piperaziny) sulfonyl] (2-methylpropyl)amino] -1S- (phenylmethyl)propyl] ]-2S- [ (1,1- dimethylethoxycarbonyl)amino]butane diamide (118 mg, 0.19 mmole) was stirred in 4N HCl in dioxane (5 mL) at r.t. for 0.5 h. Solvent and excesε reagent were evaporated to dryneεε. The product waε dried in vacuo. Thiε material (116 mg, 0.19 mmoleε) waε then reacted with 2-quinoline carboxylic acid N-hydroxysuccimide ester (53 mg, 0.19 mmoleε), DIEA (83 uL, 0.60 mmoleε) in DMF (1 mL) overnight. The product Nl- [2R-hydroxy -3- L L (4-methyl-l- piperazinyl) sulfonyl] (2-methylpropyl)amino] -1S- (phenylmethyl)propyl] -2S-[ (2- quinolinylcarbonyl)amino]butanediamid was purified by silica gel chromatography. Anal. Calcd for C33H45N7O6S. 0.5 H2O/0.3 CH3CH2OCH2CH3 : C, 58.76; H,7.06; N, 14.03. Found: C, 58.23; H, 6.98; N, 13.81. Example 16 Preparation of Nl- L3- f , (butvlamino) sulfonvll (2- methylpropyl)aminol -2R-hvdroxv-lS- (phenvlmethvl)pronvll-2S-r (2- σuinolinylcarbonyl)aminolbutanediamide Part A: The procedures described in Example 6, Partε A-C, were used to prepare phenylmethyl [3- [ [ (butylamino) sulfonyl] (2-methylpropyl)amino] -2R- hydroxy-lS- (phenylmethyl)propyl] carbamate. A methanolic solution of this carbamate (460 mg, 0.796 mmoles) was hydrogenated over 10% palladium on carbon (90 mg) to give the free amine (329 mg) . Part B: The free amine from Part A (266 mg, 0.6 mmoles) was coupled with N-BOC-L-asparagine (167 mg, 0.72 mmoleε) in the presence of N-hydroxybenzotriazole (130mg, 0.96 mmoles) and EDC (138 mg, 0.72 mmoles) to yield 306 mg of Nl[2R-hydroxy -3- [3- [ (butylamino) sulfonyl] (2-methylpropyl) amino] -1S- (phenyl ethyl)propyl! ]-2S-[ (1,1- di ethylethoxycarbonyl)amino]butane diamide after purification on a silica column. Part C : Nl [2R-hydroxy -3- [3- [ (butylamino) sulfonyl] (2-methylpropyl) amino] -IS- (phenylmethyl)propyl] ] -2S- [ (1,1- dimethylethoxycarbonyl)amino]butane diamide (150 mg, 0.26 mmoles) was stirred in 4N HCl in dioxane (4 mL) at r.t. for 0.5 h. Solvent and excess reagent were evaporated to dryness. The product was dried in vacuo. This material (140 mg, 0.26 mmoleε) was then reacted with 2-quinoline carboxylic acid N-hydroxysuccimide ester (70 mg, 0.26 mmoles) , DIEA (72 uL, 0.52 mmoles) in dichloromethane (2 mL) overnight. The product -Nl- [3- [ [ (butylamino)sulfonyl] (2-methylpropyl)amino] -2R- hydroxy-lS- (phenylmethyl)propyl] -2S- [ (2- quinolinylcarbonyl)amino]butanediamide was purified by silica gel chromatography. Anal. Calcd for C32H44N6O6S: C, 59.98; H,6.92; N, 13.12. Found: C, 59.98; H, 6.65; N, 12.72. Example 17 Preparation of Nl- 3 ϊ-T f (1.1- dimethvlehtvll)aminol sulfonyll (2-methvlpropvl)aminol-2R- hvdroxv-lS- (phenvlmethvl.pronvn-2S-.12 - cruinolinylcarbonyl)aminolbutanediamide Part A: A 20 mL methanol solution of phenylmethyl [2R- hydroxy -3-[[ (1,1-dimethylethyl)sulfonyl] (2- methylpropyl)amino]-IS- (phenylmethyl)propyJ] carbamate from Example 8 (170 mg, 0.33 mmoles) was hydrogenated over 10% palladium on carbon (40 mg) . The resulting free amine (110 mg, 0.30 mmole) was coupled with N-BOC-L- aεparagine (84 mg, 0.35 mmoles) in the presence of N- hydroxybenzotriazole (65 mg, 0.48 mmoles) and EDC (69 mg, 0.36 mmoles) to yield 160 mg of Nl[2R-hydroxy -3-[3- [ [ (1,1-dimethylethyl)amino]sulfonyl] (2- methylpropyl)amino]-IS- (phenylmethyl)propyl] ] -2S- [ (1,1- dimethylethoxycarbonyl)amino]butane diamid . Part B: Nl[2R-hydroxy -3-[3-[ [ (1,1- dimethylethyl)amino]sulfonyl] (2-methylprop l)amino]-1S- (phenylmethyl)propyl] ]-2S-[ (1,1- dimethylethoxycarbonyl)amino]butane diamide (150 mg, 0.25 mmole) was stirred in 4N HCl in dioxane (5 mL) at r.t. for 0.5 h. Solvent and exceεε reagent were evaporated to dryness. The product was dried in vacuo. This material (135 mg, 0.25 mmoles) was then reacted with 2-quinoline carboxylic acid N-hydroxysuccimide eεter (70 mg, 0.25 mmoleε), DIEA (72 uL, 0.52 mmoleε) in DMF (1 mL) overnight. The product Nl-[3[-[[(l,l- dimethylehtyl)amino] εulfonyl] (2-methylpropyl)amino] -2R- hydroxy-lS- (phenylmethyl)propyl] -2S- [ (2- quinolinylcarbonyl)amino]butanediamide waε purified by εilica gel chromatography (85 mg, 53%) . Anal. Calcd for C32H44N6O6S. 0.8 H2O: C58.66; H,7.02; N, 12.83. Found: C, 59.00; H, 6.84; N, 12.54. Example 18 Preparation of N' - f3- , , (N.N-dimethylamino) sulfonyll (3- ethylbutyl)aminol -2R-hvdroxy-lS- (phenylmethyl)propyll - 25- r (2-σuinolinvlcarbonvl) aminolbutanediamide Part A: Preparation of N-3 (S) - (Benzylox carbonyl) - amino-2 (R) -hydroxy-4-phenylbutylamine, N- (3-methylbutyl) . A εolution of 20g (67 mmol) of N-benzyloxycarbonyl-3 (S) - amino-1,2- (S) -epoxy-4-phenylbutane in 140 mL of isopropyl alcohol was treated with 83g (952 mmol) of iεoamylamine and refluxed for one hour. The solution was cooled, concentrated, hexane added and the resulting solid filtered to afford 22.4g of the deεired product. Part B : Preparation of N-3 (S) - (Benzyloxycarbonyl) - amino-2 (R) -hydroxy-4-phenylbutylamine, N- (3-methylbutyl) - N- (t-butyloxycarbonyl) . To a solution of 22.4g (58.3 mmol) of product from Part A above, 6.48g (64.1 mmol) of triethylamine and 150 mg of N,N-dimethyl-4-aminopyridine in 200 mL of tetrahydrofuran at 0°C was added 12.7g (58.3 mmol) of di-t-butylpyrόcarbonate in 10 mL of THF. After 3.5 hours at room temperature, the volatiles were removed, ethyl acetate added and washed with 5% citric acid, sat'd NaHCθ3 , dried and concentrated to afford 30g of crude product. Chromatography on silica gel using 20% ethyl acetate/hexane afforded 22.5g (79%) of the desired product. Part C: Preparation of N-3 (S) - [N-benzyloxycarbonyl-L- asparaginyl]amino-2 (R) -hydroxy-4-phenylbutylamine, N- (3- methylbutyl) -N- (t-butyloxycarbonyl) . A solution of 22.5g of product from Part B above in 200 mL of ethanol was hydrogenated over 5.9g of 10% palladium-on-carbon under 50 psig hydrogen for one hour. The catalyst was filtered and the solvent removed under reduced pressureto afford 15.7g of free amine. This was dissolved in 130 mL of DMF and 4.54g (44.9 mmol) of N-methylmorpholin an added to a mixture of 13.3g (49.9 mmol) N-benzyloxy-carbonyl-L- asparagine, 11.5g (74.9 mmol) of N-hydroxybenzotriazole and 10.5g (54.9 mmol) of EDCl in 120 mL of DMF at 0°C, which had been preactivated for one hour prior to the addition. The mixture waε εtirred for 2 hourε at 0°C and then for 12 hours at room temperature. The reaction waε poured into IL of εat'd aqueouε εodium bicarbonate, the εolid collected, diεεolved in ethyl acetate, waεhed with water., εat'd εodium bicarbonate, 5% citric acid and brine, dried and concentrated to afford 16.7g of the deεired product. Part D Preparation of N-3 (S) - [N- (2- quinolinylcarbonyl) -L-asparaginyl]amino-2 (R) -hydroxy-4- phenylbutylamine, N- (3-methylbutyl) -N- (t- butyloxycarbonyl) . A solution of 16.7g (28.0 mmol) of product from Part C in 250 mL of methanol was hydrogenated over 6.0g of 10% palladium-on-carbon and under 50 psig hydrogen for one hour. The catalyεt waε filtered and the solution concentrated to afford 10.Og of free amine. This was dissolved in 100 mL of methylene chloride, 4.35g (43 mmol) of N-methylmorpholine waε added followed by 5.53g (20.5 mmol) of quino.ιne-2- carboxylic acid, N-hydroxysuccinimide ester. This was stirred at room temperature overnight, the solvent removed, ethyl acetate added and washed with 5% citric acid, sat'd sodium bicarbonate, brine, dried and concentrated to afford 14g of crude product. Recrystallization from ethyl acetate and hexane afforded 10.5g (83%) of desired product. Part E: Preparation of N-3 (S) - [N- (2-quinolinyl- carbonyl) -L-asparaginyl]amino-2 (R) -hydroxy-4- phenylbutylamine, N- (3-methylbutyl) . To 80 mL of 4N hydrochloric acid in dioxane was added 9.17g (14.8 mmol) of product from Part D above. After one hour, the product becomes gummy. The solvents were removed, diethyl ether added and removed and the residue disεolved in 20 mL of methanol. Thiε εolution waε added to 400 mL of εat'd aqueouε εodium bicarbonate, the εolidε collected, waεhed with acetone and hexane and dried in vacuo over P2O5 to afford 4.75g of the deεired product. Part F : To a solution of 200 mg (0.38 mmol) of the amino alcohol from Part E above in 10 mL of anhydrons tetrahydrofuran and 0.3 mL of N,N-dimethylformamide, waε added 42 mg (0.42 mmol) of triethylamine and then 55 mg (0.38 mmol) of dimethylsulfamoyl chloride. 'After stirring from twenty hours at room temperature, the volatiles were removed in vacuo, ethyl acetate added and the solution washed with 5% aqueous citric acid, saturated aqueouε sodium bicarbonate and saturated brine. The organic layer was dried and concentrated to afford 166 mg of crude product, which was chromatographed on εilica gel using a gradient of 1-10% isopropanol in methylene chloride to afford 119 mg of pure product, m/e 627 (M+H) . Calcd. for C 31 H 42 N 5 0 6 S 627.2965, found 627 . 2998 . Example 19 Preparation of f (4-methoxvphenvl)methvll \ ?> - , .3-r . r (1.1- dime hvlethvl)aminol sulfonvll (2-methylpropyl) aminol -2R- hydroxy-lS- (phenylmethyl)propyll aminol -2R-methyl-3- oxopropyl1 carbamate To a solution of 83 mg (0.31 mmol) of N-(4- methoxy)benzyloxycarbonyl 2R-methyl-3-aminopropionic acid and 71 mg (0.46 mmol) of N-hydroxybenzotraazole in 2 mL of anhydrous N,N-dimethylformamide (DMF) at O'C, waε added 65 mg (0.34 mmol) of 1- (3-dimethylammopropyl) -3- ethylcarbodiimide hydrochloride. After tw.> hours at O'C, a εolution of 104 mg (0.28 mmol) of free amine from example 8, part C in 0.5 mL of DMF waε added. After two hours at O'C and fourteen hours at room temperature, the DMF was removed in vacuo, ethyl acetate added, waεhed with saturated aqueous εodium bicarbonate, brine, dried over anhydrous magnesium sulfate, filtered and concentrated to afford 200 mg of crude materal. This waε chromatographed on silica gel using 3% methanol/methylene chloride to afford 120 mg of product, which was further purified by crystallization from diethyl ether/hexane to afford 25 mg (13%) of the desired product m/e = 627 (M+Li) . Example 20 Preparation of N4- F3- f r r (1. l-dimethvlethv_.)aminol - sulfonyl! (2-methylpropyl)aminol -2R-hvdroxy-l£- (phenylmethyl)propyll -2S-T (2-σuinolinylcarbonyl) - amin 1butanediamide 107 mg (0.37 mmol) of N-2- (quinoylcarbonyl) -L- iεoaεparagine and 76 mg (1.5 eq) of were diεεolved in 2 mL of dimethylformamid'. and cooled to zero degreeε C. To this was added 111 mg (0.37 mmol) of EDC and the solution stirred for 20 minuter. To this cooled solution was added 140 mg (0.37 mmo ' i ) of the free amine from example 8, part C and the reaction waε returned to room temperature and stirred for 18 hours. The dimethylformamide was removed by evaporation and the residue was partitioned between ethyl acetate and saturated sodium bicarbonate. The organic layer was washed with 5% KHSO. and brine, dried over magnesium sulfate, filtered and concentrated to yield 216 mg of crude solid, which was chromatographed using ethyl acetate:methanol:hexane, 95:5:50 to yield 110 mg (4.8% yield) of pure product, m/e = 641 (M+H) . Exampl 21 Following the procedures of Exampleε 1-20, the compoundε shown in Tables 3A and 3B were prepared. TABLE 3A R- Entry No. Rl R3 R4 R5 TABLE 3B Ent ry Rl R3 R4 R5 A Cbz t-butyl B Cbz t-butyl C N,N-Dimethylglycine t-butyl D Q CH2CONH2 E Q CH 2 C0NH 2 F N,N-Dimethylglycine t-butyl Utilizing the procedureε set forth above, the compounds shown in Tables 4-14 could be prepared. Thuε, utilizing the intermediates of Examples 1-10 according to the procedures in Examples 14-21, the compounds shown in Tables 4-16 could be prepared. TABLE 4 Entry No, R3 R4 R5 TABLE 4 (Cont'd.) Entry R3 R4 R5 No. 57 -CH2CH(CH3)2 -C6H5 M e 58 -CH2CH ( CH3 ) 2 -C6H5 Me 59 -CH2CH(CH3)2 -C6H5 H TABLE 4 (Cont'd.) Entry R3 4 R5 TABLE 4 (Cont'd.) Entry R3 4 R5 No. 74 -CH2 -©• -Ph H TABLE 4 (Cont'd. ) a benzyloxycarbonyl b 2-quinolinylcarbonyl Entry R3 R4 No . TABLE 5 (Cont'd) Entry R3 R4 TABLE 6 Entry R4 TABLE 7 Entry R2 TABLE 7 (Cont'd) Entry R2 TABLE 8 Entry R3 4 TABLE 9 T-afrle 9 (Cont'd) Entry HO2CCH2CH2- C - ~ CH 3 O 10 II -CH3 CH3NH- C - O 11 II -CH3 (CH 3 ) 2 CH-C- 12 II -CH3 CH3OCH2- c - 13 I -CH3 (CH 3 )2NCH2-C- 14 -CH3 -CH3 -CH 3 TABLE 9 ( Cont ' d ) Entry TABLE 10 Entry Rl Rl ' Rl " TABLE 11 Entry X=H X=H X=H X=F X=F X=H X=H R+R'=pyrrole X=H TABLE 12 Entry Acyl Group (R) 1 benzyloxycarbonyl 2 tert-butoxvcarbonvl 3 acetyl 4 2-quinoylcarbonyl 5 phenoxyacetyl 6 benzoyl 7 methyloxaloyl 8 pivaloyl 9 trifluoracetyl 10 bromoacetyl 11 hydroxyacetyl 12 morpholinylacetyl 13 N,N-dimethylaminoacetyl 14 N-benzylaminoacetyl 15 N-phenylaminoacetyl 16 N-benzy1-N-methylaminoacetyl 17 N-methyl-N- (2-hydroxyethyi.aminoacetyl 18 N-methylcarbamoyl 19 3-methylbutyry1 20 N-isobutylcarbamoyl 21 succinoyl (3-carboxypropionyl) 22 carbamoyl 23 N- (2-indany1)aminoacety1 24 N-methylaminoacetyl TABLE 1 -n-Butyl -CH 3 -n-Butyl -n-Butyl -n-Butyl -n-Butyl -n-ButyJ -n-Butyl -n-Propyl -CH2CH ( CH3 ) 2 -n-Butyl -i-Propyl -CH2CH2CH ( CH3 ) 2 -CH2CH3 -CH ( CH3 ) 2 -o TABLE 13 (Cont'd) Entry R3 R4 TABLE 13 (Cont'd) Entry R3 R4 TABLE 13 (Cont'd) λ Table 14 Entry R 1 R 3 TABLE 15 N— R 4 R3 -CH2CH(CH3)2 -N(CH3)2 -CH2CH(CH3)2 -N(CH2CH3)2 -CH2CH(CH3)2 -N(CH (CH3 ) 2 ) 2 -CH2CH2CH(CH3)2 -N (0,3)2 -CH2CH2CH(CH3)2 -N(CH2CH3)2 \ -CH 2 CH 2 CH(CH 3 )2 N D TABLE 15 (Cont'd.) — N— R 4 R3 TABLE 16 N- R 3 A> -CH2CH ( CH3)2 -N ( CH3 ) 2 -CH2CH ( CH3)2 -N ( CH2CH3 ) 2 -CH2CH ( CH3)2 -N ( CH ( CH3 ) 2 ) 2 -CH2CH2CH ( CH3 ) 2 -N ( CH3 ) 2 -CH2CH2CH ( CH3)2 -N(CH2CH3)2 -CH2CH2CH ( CH3)2 - -N(CH2CH3 ) 2 TABLE 16 (Cont'd. ) — N— F-L R3 R β - - ■ TABLE 16 (Cont'd.) N- R3 A. -CH2CH(CH3)2 -j O Exam le 22 The compounds of the present invention are effective HIV protease inhibitors. Utilizing an enzyme assay as described below, the compounds set forth in the examples herein disclosed inhibited the HIV enzyme. The preferred compounds of the present invention and their calculated IC50 (inhibiting concentration 50%, i.e., the concentration at which the inhibitor compound reduces enzyme activity by 50%) values are shown in Table 17. The enzyme method is described below. The substrate is 2-Ile-Nle-Phe (p-N02) -Gln-ArgNH2 • The positive control is MVT-101 (Miller, M. et al, Science. 246. 1149 (1989)] The assay conditions are as follows: Assay buffer: 20 mM sodium phosphate, pH 6.4 20% glycerol 1 mM EDTA 1 mM DTT 0.1% CHAPS The above described substrate is dissolved in DMSO, then diluted 10 fold in assay buffer. Final substrate concentration in the assay is 80 μM. HIV protease is diluted in the as ay buffer to a final enzyme concentration of 12.3 nanomolar, based on a molecular weight of 10,780. The final concentration of DMSO is 14% and the final concentration of glycerol is 18%. The test compound is dissolved in DMSO and diluted in DMSO to lOx the test concentration; lOμl of the enzyme preparation is added, the materials mixed and then the mixture is incubated at ambient temperature for 15 minutes. The enzyme reaction is initiated by the addition of 40μl of substrate. The increase in fluorescence is monitored at 4 time points (0, 8, 16 and 24 minutes) at ambient temperature. Each assay is carried out in duplicate wells. The preceding examples can be repeated with similar success by substituting the generically or specifically described reactants and/or operating conditions of this invention for those used in the preceding examples. TABLE 17 Entry Compound IC50 (nanomolar) Example 23 The effectiveness of the compoundε listed in Table 17 were determined in the above-described enzyme assay and in a CEM cell assay. The HIV inhibition assay method of acutely infected cells is an automated tetrazolium based colorimetric assay essentially that reported by Pauwles et al, -T. Virol. Methods. 2£, 309-321 (1988) . Assays were performed in 96-well tissue culture plates. CEM cells, a CD4+ cell line, were grown in RPMI-1640 medium (Gibco) supplemented with a 10% fetal calf serum and were then treated with polybrene (2μg/ml) . An 80 μl volume of medium containing 1 x 10 4 cells was dispensed into each well of the tissue culture plate. To each well was added a lOOμl volume of test compound dissolved in tissue culture medium (or medium without test compound as a control) to achieve the desired final concentration and the cells were incubated at 37°C for 1 hour. A frozen culture of HIV-1 was diluted in culture medium to a concentration of 5 x 10 4 TCID50 per ml (TCID50 = the dose of virus that infects 50% of cells in tissue culture) , and a 20μL volume of the virus sample (containing 1000 TCID50 of virus) was added to wells containing test compound and to wells containing only medium (infected control cells) . Several wells received culture medium without virus (uninfected control cells) . Likewise, the intrinsic toxicity of the test compound was determined by adding medium without virus to several wells containing test compound. In summary, the tissue culture plates contained the following experiments: Cells Drug Virus 1. + 2. + + 3. + - + 4. + + + In experiments 2 and 4 the final concentrations of test compounds were 1, 10, 100 and 500 μg/ml. Either azidothymidine (AZT) or dideoxyinosine (ddl) was included as a positive drug control. Test compounds were dissolved in DMSO and diluted into tissue culture medium so that the final DMSO concentration did not exceed 1.5% in any case. DMSO was added to all control wells at an appropriate concentration. Following the addition of virus, cells were incubated at 37°C in a humidified, 5% CO2 atmosphere for 7 days. Test compounds could be added on days 0, 2 and 5 if desired. On day 7, post-infection, the cells in each well were resuspended and a lOOμl sample of each cell suspension was removed for assay. A 20μL volume of a 5 mg/ml solution of 3- (4, 5-dimethylthiazol-2-yl) -2, 5- diphenyltetrazolium bromide (MTT) was added to each lOOμL cell suspension, and the cells were incubated for 4 hours at 27°C in a 5% C02 environment. During this incubation, MTT is metabolically reduced by living cells resulting in the production in the cell of a colored formazan product. To each sample was added lOOμl of 10% εodium dodecylsulfate in 0.01 N HCl to lyse the cells, and samples were incubated overnight. The absorbance at 590 nm was determined for each sample using a Molecular Devices microplate reader. Absorbance values for each set of wells is compared to assess viral control infection, uninfected control cell response as well as test compound by cytotoxicity and antiviral efficacy. The biological data shown in Tables 18 and 19 were obtained from the compounds shown in Tables IC and 3B, respectively. TABLE 18 Entry IC50 or EC50 TD50 Table IC Inhibition A 29% @ 0.1 uM B 55% @ 10.0 uM C 59% @ 1.0 uM D 29% 8 0.1 uM E 70 nM 880 nM 7.5 uM F 22% @ 0.1 uM G 66 nM H 48% @ 10.0 uM I 1.7 uM J 2.69 uM K 60% @ 1.0 uM L 38% @ 10.0 uM TABLE 20 Entry Compound IC5o(nm) EC5o(nm) TDso(nm) The compounds of the present invention are effective antiviral compounds and, in particular, are effective retroviral inhibitors as shown above. Thus, the subject compounds are effective HIV protease inhibitors. It is contemplated that the subject compounds will also inhibit other retroviruses such as other lentiviruses in particular other strains of HIV, e.g. HIV-2, human T-cell leukemia virus, respiratory syncitial virus, simia immunodeficiency virus, feline leukemia virus, feline immuno-deficiency virus, hepadnavirus, cytomegalovirus and picornavirus. Thus, the subject compounds are effective in the treatment and/or proplylaxis of retroviral infections. Compounds of the present invention can possess one or more asymmetric carbon atoms and are thus capable of existing in the form of optical isomers as well as in the form of racemic or nonracemic mixtures thereof. The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, for example by formation of diastereoisomeric salts by treatment with an optically active acid or base. Examples of appropriate acids are tartaric, diacetyltartaric, dibenzoyltartaric, ditoluoyltartaric and camphorsulfonic acid and then separation of the mixture of diastereoisomers by crystallization followed by liberation of the optically active bases from these salts. A different process for separation of optical isomers involves the use of a chiral chromatography column optimally chosen to maximize the separation of the enantiomers. Still another available method involves synthesis of covalent diastereoisomeric molecules by reacting compounds of Formula I with an optically pure acid in an activated form or an optically pure isocyanate. The synthesized diastereoisomers can be separated by conventional means such as chromatography, distillation, crystallization or sublimation, and then hydrolyzed to deliver the enantiomerically pure compound. The optically active compounds of Formula I can likewise be obtained by utilizing optically active starting materials. These isomers may be in the form of a free acid, a free base, an ester or a salt. The compounds of the present invention can be used in the form of salts derived from inorganic or organic acids. These salts include but are not limited to the following: acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, cyclopentanepropionate, dodecylsulfate, ethanesulfonate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobrnmide, hydroiodide, 2-hydroxy-ethanesulfonate, lactate, maleate, methaneεulfonate, nicotinate, 2-naphthalenesulfonate, oxalate, palmoate, pectinate, persulfate, 3-phenylpro- pionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, tosylate, mesylate and undecanoate. Also, the basic nitrogen-containing groups can be quaternized with such agents as lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides, and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides, and others. Water or oil-soluble or dispersible products are thereby obtained. Examples of acids which may be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, sulphuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid and citric acid. Other examples include salts with alkali metals or alkaline earth metals, such as sodium, potassium, calcium or magnesium or with organic bases. Total daily dose administered to a host in single or divided doses may be in amounts, for example, from 0.001 to 50 mg/kg body weight daily and more usually 0.01 to 1 mg. Dosage unit compositions may contain such amounts of submultiples thereof to make up the daily dose. The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. The dosage regimen for treating a disease condition with the compounds and/or compositions of this invention is selected in accordance with a variety of factors, including the type, age, weight, sex, diet and medical condition of the patient, the severity of the disease, the route of administration, pharmacological considerations such as the activity, efficacy, pharmacokinetic and toxicology profiles of the particular compound employed, whether a drug delivery system is utilized and whether the compound is administered as part of a drug combination. Thus, the dosage regimen actually employed may vary widely and therefore may deviate from the preferred dosage regimen set forth above. The compounds of the present invention may be administered orally, parenterally, by inhalation spray, rectally, or topically in dosage unit formulations containing conventional nontoxic pharmaceutically acceptable carriers, adjuvants, and vehicles as desired. Topical administration may also involve the use of transdermal administration such as transdermal patches or iontophoresis devices. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection, or infusion techniques. Injectable preparations, for example, sterile injectable aqueous or oleaginous suspensions may be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution or suspension in a nontoxic parenterally acceptable diluent or solvent, for example, as a solution in 1, 3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono- or diglycerides. In additi.on, fatty acids such as oleic acid find use in the preparation of injectables. Suppositories for rectal administration of the drug can be prepared by mixing the drug with a suitable nonirritating excipient such as cocoa butter and polyethylene glycols which are solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum and release the drug. Solid dosage forms for oral administration may include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound may be admixed with at least one inert diluent such as sucrose lactose or starch. Such dosage forms may also comprise, as in normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate. In the case of capsules, tablets, and pills, the dosage forms may also comprise buffering agents. Tablets and pills can additionally be prepared with enteric coatings. Liquid dosage forms for oral administration may include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixirs containing inert diluents commonly used in the art, such as water. Such compositions may also comprise adjuvants, such as wetting agents, emulsifying and suspending agents, and sweetening, flavoring, and perfuming agents. While the compounds of the invention can be administered as the sole active pharmaceutical agent, they can also be used in combination with one or more immunomodulators, antiviral agents or other antiinfective agents. For example, the compounds of the invention can be administered in combination with AZT, DDI, DDC or with glucosidase inhibitors, such as N-butyl-1-deoxynojirimycin or prodrugs thereof, for the prophylaxis and/or treatment of AIDS. When administered as a combination, the therapeutic agents can be formulated as separate compositions which are given at the same time or different times, or the therapeutic agents can be given as a single composition. The foregoing is merely illustrative of the invention and is not intended to limit the invention to the disclosed compounds. Variations and changes which are obvious to one skilled in the art are intended to be within the scope and nature of the invention which are defined in the appended claims. From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions.

Claims: WHAT IS CLAIMED IS: 1. A compound represented by the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof wherein: R represents hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, alkoxycarbonyl, aryloxyalkyl, heteroaryloxyalkyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy¬ carbonyl, heteroaroyl, alkoxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or wherein said aminocarbonyl and aminoalkanoyl radicals are disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R3 or R"Sθ 2 - wherein R" represents radicals as defined for R 3 ; or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3. -C (CH 3 ) 2 (SH) , -C (CH3) 2 (SCH3) , -C(CH3)2 (S[0]CH3) , -C (CH3)2 (S [O] 2CH3 ) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-alkyl serine, aspartic acid, beta-cyano alanine and valine side chains; Rl' and Rl" independently represent hydrogen and radicals as defined for R1» or one of Rl ' and Rl", together with Rl and the carbon atoms to which Rl, Rl ' and Rl" are attached, represent a cycloalkyl radical; R2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R9 represents hydrogen and alkyl radicals; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R3 or together with a nitrogen atom to which they are bonded form a heterocycloalkyl or a heteroaryl radical; Rδ represents hydrogen and alkyl radicals; x represents 1 or 2; t represents either 0, 1 or 2; and Y represents 0, S and NRl5 wherein R! 5 represents hydrogen and radicals as defined for R3. 2. Compound represented by the formula: wherein: R represents hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, hydroxyalkyl, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxycarbonyl, heteroaroyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3, -CO2CH3, -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3) 2 (SCH3) , -C(CH3)2(S[0]CH3) , -C (CH3)2 (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-methyl serine, aspartic acid, beta-cyanoalanine and valine side chains; R 2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radials, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R represents hydrogen and alkyl radicals; R represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R3 , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals. 3. Compound of Claim 2 wherein R represents aralkoxycarbonyl and heteroaroyl radicals. 4. Compound of Claim 2 wherein R represents carbobenzoxy, 2-benzofurancarbonyl and 2-quinolinylcarbonyl radicals. 5. Compound of Claim 2 where R represents acetyl, N,N-dimethylaminoacetyl, N-methylaminoacetyl or N-benzyl-N-methylaminoacetyl. 6. Compound of Claim 2 wherein Rl represents alkyl, alkynyl and alkenyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, threonine, allo-threonine, isoleucine, S-methyl cysteine and the sulfone and sulfoxide derivatives thereof, alanine, and allo-isoleucine. 7. Compound of Claim 2 wherein R represents methyl, propargyl, t-butyl, isopropyl and sec-butyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, S-methyl cysteine, allo-iso-leucine, iso-leucine, threonine, serine, aspartic acid, beta-cyano alanine, and allo- threonine side chains. 8. Compound of Claim 2 wherein R2 represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented by the formula -OR^' and -SR9 wherein R9 represents hydrogen and alkyl radicals. 9. Compound of Claim 2 wherein R2 represents alkyl, cycloalkylalkyl and aralkyl radicals. 10. Compound of Claim 2 wherein R2 represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethy1 and cyclohexylmethyl radicals. 11. Compound of Claim 2 wherein R3 independently represents alkyl, haloalkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl and heteroaralkyl radicals. 12. Compound of Claim 2 wherein R represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, heterocycloalkyl, heterocycloalkylalkyl radicals. 13. Compound of Claim 2 wherein R and R 4 independently represent alkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 14. Compound of Claim 2 wherein R represents isobutyl, n-propyl, isopropyl, n-butyl, isoamyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals. 15. Compound of Claim 2 wherein R is an isobutyl, n-butyl or isoamyl radical and R 4 is a tertiary-butyl radical. 16. Compound of Claim 2 wherein R is an isobutyl, n-butyl or isoamyl radical and R 4 is a phenyl radical. 17. Compound of Claim 2 wherein R 4 and R 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 18. Compound f Claim 2 wherein R 4 and R^ independently represent hydrogen, alkyl and aryl radicals. 19. Compound of Claim 2 wherein R 4 and R 5 independently represent hydrogen, methyl, ethyl, isopropyl, n-butyl, t-butyl, 1, 1-dimethylpropyl, cyclohexyl and phenyl radicals. 20. Compound of Claim 2 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a heterocyloalkyl or heteroaryl radical. 21. Compound of Claim 2 wherein R 4 and R 5 together with the nitrogen atom to which they are bonded form a heterocycloalkyl or heteroaryl radical having from 4 to 8 ring members. 22. Compound of Claim 2 wherein R 4 and R^ together with the nitrogen atom to which tney are bonded form a pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl radical. 23. A pharmaceutical composition comprising a compound of Claim 1 and a pharmaceutically acceptable carrier. 24. A pharmaceutical composition comprising a compound of Claim 2 and a pharmaceutically acceptable carrier. 25. Method of inhibiting a retroviral protease comprising administering a protease inhibiting amount of a composition of Claim 23. 26. Method of Claim 25 wherein the retroviral protease is HIV protease. 27. Method of treating a retroviral infection comprising administering an effective amount of a composition of Claim 23. 28. Method of Claim 27 wherein the retroviral infection is an HIV infection. 29. Method for treating AIDS comprising administering an effective amount of a composition of Claim 23. 30. Method of inhibiting a retroviral protease comprising administering a protease inhibiting amount of a composition of Claim 24. 31. Method of Claim 30 wherein the retroviral protease is HIV protease. 32. Method of treating a retroviral infection comprising administering an effective amount of a composition of Claim 24. 33. Method of Claim 30 wherein the retroviral infection is an HIV infection. 34. Method for treating AIDS comprising administering an effective amount of a composition of Claim 24. 35. Compound represented by the formula: R represents hydrogen, alkoxycarbonyl, araikoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy-carbonyl, heteroaroyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R3 or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3, -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3) 2 (SCH3) , -C(CH3)2(S[0]CH3) , -C (CH3) 2 (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from aεparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, hiεtidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, aspartic acid, beta cyanoalanine and valine side chains; R represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R represents hydrogen and alkyl radicals; R represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide derivatives thereof; R 4 and R 5 independently represent hydrogen and radicals as defined by R3 , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals. 36. Compound of Claim 35 wherein Rl represents hydrogen, alkyl, alkenyl and alkynyl radicals. 37. Compound of Claim 35 wherein Rl represents methyl, ethyl, isopropyl, propargyl and t-butyl radicals. 38. Compound of Claim 35 wherein R' is 39. Compound of Claim 35 wherein R' is hydrogen and R represents acetyl, phenoxyacetyl, 2-naphthyloxy-carbonyl, benzyloxycarbonyl, p-methoxybenzyloxycarbonyl. 40. Compound of Claim 35 wherein R and R' are independently selected from methyl and phenethyl radicals. 41. Compound of Claim 35 wherein R2 represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented by the formula -OR9 and -SR9 wherein R9 represents hydrogen and alkyl radicals. 42. Compound of Claim 35 wherein R represents alkyl, cycloalkylalkyl and aralkyl radicals. 43. Compound of Claim 35 wherein R2 represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals. 44. Compound of Claim 35 wherein R2 represents benzyl, 4-fluorobenzyl, and 2-naphthylmeth 1 radicals. 45. Compound of Claim 35 wherein R independently represents alkyl, haloalkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl and heteroaralkyl radicals. 46. Compound of Claim 35 wherein R3 represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, heterocycloalkyl, heterocycloalkylalkyl radicals. 47. Compound of Claim 35 wherein R3 and R 4 independently represent alkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 48. Compound of Claim 35 wherein R3 represents isobutyl, n-propyl, isopropyl, n-butyl, isoamyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals. 49. Compound of Claim 35 wherein R3 is an isobutyl, n-butyl or t-butyl radical and R 4 is a t-butyl radical. 50. Compound of Claim 35 wherein R3 is an isobutyl, n-butyl or isoamyl radical and R 4 is a phenyl radical. 51. Compound of Claim 35 wherein R 4 and R^ independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 52. Compound of Claim 35 wherein R 4 and R^ independently represent hydrogen, alkyl and aryl radicals. 53. Compound of Claim 35 wherein R 4 and R^ independently represent hydrogen, methyl, ethyl, isopropyl, n-butyl, cyclohexyl, t-butyl, 1,1- dimethylpropyl and phenyl radicals. 54. Compound of Claim 35 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a heterocyloalkyl or heteroaryl radical. 55. Compound of Claim 35 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a heterocycloalkyl or heteroaryl radical having from 4 to 8 ring members. 56. Compound of Claim 35 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl radical. 57. A pharmaceutical composition comprising a compound of Claim 35 and a pharmaceutically acceptable carrier. 58. Method of inhibiting a retroviral protease comprising administering a protease inhibiting amount of a composition of Claim 57. 59. Method of Claim 58 wherein the retroviral protease is HIV protease. 60. Method of treating a retroviral infection comprising administering an effective amount of a composition of Claim 57. 61. Method of Claim 60 wherein the retroviral infection is an HIV infection. 62. Method for treating AIDS comprising administering an effective amount of a composition of Claim 57. 63. Compound represented by the formula: R represents hydrogen, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkano l , heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy-carbonyl, heteroaroyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl, and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicals, or where said aminoalkanoyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R' represents hydrogen and radicals as defined for R or R and R' together with the nitrogen to which they are attached represent heterocycloalkyl and heteroaryl radical; Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3, -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) (SH) , -C (CH3 )2 (SCH3) , -C(CH3)2(S[0]CH3) , -C (CH3) 2 (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine and methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalani.ie, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, aspartic acid, beta-cyano alanine and valine side chains; Rl ' and Rl" independently represent hydrogen and radicals as defined for Rl or one of Rl ' and Rl", together with Rl and the carbon atoms to which Rl, Rl ' and Rl" are attached, represent a cycloalkyl radical; R represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radials, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R9 represents hydrogen and alkyl radicals; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or εulfoxide derivatives thereof; R4 and R- independently represent hydrogen and radicals as defined by R , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals. 64. Compound of Claim 63 wherein R' represents hydrogen and R represents aralkoxycarbonyl and heteroaroyl radicals. 65. Compound of Claim 63 wherein R 1 is hydrogen and R represents carbobenzoxy, 2-benzofurancarbonyl, and 2-quinolinylcarbonyl radicals. 66. Compound of Claim 63 wherein R' is hydrogen and R is 2-quinolinylcarbonyl. 67. Compound of Claim 63 wherein R / Rl' and R!" independently represent hydrogen and alkyl radicals having from 1 to about 4 carbon atomε, alkenyl, alkynyl, aralkyl radicals and radicals selected from -CH2SO2NH2, -C0 2 CH 3 , -CONHCH 3 , -CON(CH 3 ) 2 , -CH 2 C(0)NHCH 3 , -CH 2 C(0)N(CH 3 ) 2 , -C0NH 2 , -C(CH 3 ) 2 (SCH 3 ) , -C(CH 3 ) 2 (S[0]CH 3 ) and -C(CH 3 ) 2 (S[0]CH 3 ) . 68. Compound of Claim 63 wherein Rl R l' and R!" independently represent hydrogen, methyl, ethyl, benzyl, phenylpropyl, propargyl, hydroxyl and radicals selected from -C(0)0CH 3 , -C(0)NH 2 , -C(0)0H. 69. Compound of Claim 63 wherein Rl and Rl' are both hydrogen and Rl" is C(0)NH2. 70. Compound of Claim 63 wherein R represents aralkoxycarbonyl and heteroaroyl radicals. 71. Compound of Claim 63 wherein R and Rl' are both hydrogen and Rl" is methyl. 72. Compound of Claim 63 wherein Rl' is hydrogen and Rl and Rl" together with the carbon atoms to which they are attached form a three to six-membered cycloalkyl radical. 73. Compound of Claim 63 wherein R is carbobenzoxy, 2-quinolinylcarbonyl and 2-benzofuran carbonyl radicals. 74. Compound of Claim 63 wherein Rl and R!' are both hydrogen and R!" is propargyl. 75. Compound of Claim 63 wherein R represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented by the formula -CR9 and -SR9 wherein R represents hydrogen and alkyl radicals. 76. Compound of Claim 63 wherein R2 represents alkyl, cycloalkylalkyl and aralkyl radicals. 77. Compound of Claim 63 wherein R2 representε aralkyl radicalε. 78. Compound of Claim 63 wherein R3 independently repreεentε alkyl, haloalkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl and heteroaralkyl radicals. 79. Compound of Claim 63 wherein R3 represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, heterocycloalkyl, heterocycloalkylalkyl radicals. 80. Compound of Claim 63 wherein R3 and R 4 independently represent alkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 81. Compound of Claim 63 wherein R3 represents isobutyl, n-propyl, isopropyl, n-butyl, iεoamyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals. 82. Compound of Claim 63 wherein R3 is an isobutyl, n-butyl or isoamyl radical and F- 4 i„, a tert- butyl radical. 83. Compound of Claim 63 wherein R is an isobutyl, n-butyl or isoamyl radical and R 4 is a phenyl radical. 84. Compound of Claim 63 wherein R 4 and R 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 85. Compound of Claim 63 wherein R 4 and R^ independently represent hydrogen, alkyl and aryl radicals. 86. Compound of Claim 63 wherein R 4 and R^ independently represent hydrogen, methyl, ethyl, isopropyl, n-butyl, t-butyl, cyclohexyl, 1,1- dimethylpropyl and phenyl radicals. 87. Compound of Claim 63 wherein R 4 and R 5 together with the nitrogen atom to which they are bonded form a heterocyloalkyl or heteroaryl radical. 88. Compound. of Claim 63 wherein R 4 and R5 together with the nitrogen atom to which they are bonded form a heterocycloalkyl or heteroaryl radical having from 4 to 8 ring members. 89. Compound of Claim 63 wherein R 4 and R5 together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl radical. 90. A pharmaceutical composition comprising a compound of Claim 63 and a pharmaceutically acceptable carrier. 91. Method of inhibiting a retroviral protease comprising administering a protease inhibiting amount of a composition of Claim 89. 92. Method of Claim 90 wherein the retroviral protease is HIV protease. 93. Method of treating a retroviral infection comprising administering an effective amount of a composition of Claim 89. 94. Method of Claim 92 wherein the retroviral infection is an HIV infection. 95. Method for treating AIDS comprising administering an effective amount of a composition of Claim 89. 96. A compound of Claim 1 which is: N-[3-[ [ (butylamino)sulfonyl] (2-methylpropyl)amino]-2R- hydroxy-lS- (phenylmethyl)propyl] -2S-[ [ 2- (dimethylamino) - 1-oxoethyl]amino]dimethylbutanamide; N-[3-[ [ (methylamino)sulfonyl] (2-methylpropyl)amino]-2R- hydroxy-lS- (phenylmethyl)propyl] -2S-[ [2- (dimethylamino) - 1-oxoethyl]amino]dimethylbutaneamide; Nl- [2R-hydroxy-3-[ [ (4-methyl-1-piperazinyl)sulfonyl] (2- methylpropyl)amino]-IS- (phenylmethyl)propyl] -2S-[ (2- quinolinylcarbonyl)amino]butanediamide; Nl-[3-[[ (butylamino)sulfonyl] (2-methylpropyl)amino]-2R- hydroxy-lS- (phenylmethyl)propyl] -2S-[ (2- quinolinylcarbonyl)amino]butanediamide; Nl- [3 [-[ [ (1,1-dimethylehtyll)amino] sulfonyl ] (2- methylpropyl)amino] -2R-hydroxy-lS- (phenylmethyl)propyl] - 2S- [ (2-quinolinylcarbonyl)amino]butanediamιde; N' - [3-[ [phenylamino]sulfonyl] (2-methylpropyl)amino] -2R- hydroxy-lS- (phenylmethyl)propyl] -2S- [ (2- quinolinylcarbonyl)amino]butanediamide; or N' - [3- [ [cyclohexylamino] sulfonyl] (2-methylpropyl)amino] - 2R-hydroxy-lS- (phenylmethyl)propyl] -2S- [ (2- quinolinylcarbonyl)amino]butanediamide. 97. A compound represented by the formula: wherein : P 1 and P 2 independently represent hydrogen, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, cycloalkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylalkanoyl, alkanoyl, aralkanoyl, aroyl, aryloxycarbonyl, aryloxycarbonylalkyl, aryloxyalkanoyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclylalkanoyl, heterocyclylalkoxycarbonyl, heteroaralkanoyl, heteroaralkoxycarbonyl, heteroaryloxy¬ carbonyl, heteroaroyl, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, hydroxyalkyl, aminocarbonyl, aminoalkanoyl and mono- and disubstituted aminocarbonyl and mono- and disubstituted aminoalkanoyl radicals wherein the substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heterocycloalkyalkyl radicalε, or where said aminoalkanoyl radical is disubstitut- d ._aid subεtituents along with the nitrogen atom to which they are attached form a heterocycloalkyl or heteroaryl radical; R 2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicalε are optionally εubεtituted with a group selected from alkyl and halogen radicalε, -N02, -C≡N, CF 3 , -OR9, -SR9, wherein R repreεentε hydrogen and alkyl radicals; R3 representε hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and diεubεtituted am_.no?. kyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone or sulfoxide derivatives thereof; R 4 and R 5 independently represent hydrogen and radicals as defined by R3 or together with a nitrogen atom to which they are bonded form a heterocycloalkyl or a heteroaryl radical. 98. Compound of Claim 97 wherein R represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl ar.d mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl. aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical; and R 4 and R 5 independently represent hydrogen and radicals as defined by R3 , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals. 99. A pharmaceutical composition comprising a compound of Claim 97 and a pharmaceutically acceptable carrier. 100. Method of inhibiting a retroviral proteaεe compriεing adminiεtering a proteaεe inhibiting amount of a compoεition of Claim 99. 101. Method of Claim 100 wherein the retroviral proteaεe is HIV protease. 102. Method of treating a retroviral infection comprising administering an effective amount of a composition of Claim 99. 103. Method of Claim 101 wherein the retroviral infection is an HIV infection. 104. Method for treating AIDS comprising administering an effective amount of a composition of Claim 99. 105. A compound of Claim 97 whiui. is: phenylmethyl [2R-hydroxy-3- [ [ (dimethylamino) sulfonyl] (2- methylpropyl)amino] -IS- (phenylmethyl)propyl] carbamate; phenylmethyl [2R-hydroxy-3- [ [ (dimethylamino) sulfonyl] (3- methylbutyl)amino] -IS- (phenylmethyl)propyljcarbamate; phenylmethyl [3- [[ (butylamino)sulfonyl] (2- methylpropyl)amino] -2R-hydroxy-lS- (phenylmethyl)propyl] carbamate; phenylmethyl [2R-hydroxy-3- [ [ (4-methyl-1- piperazinyl) sulfonyl] (2-methylpropyl)amino] -1S- (phenylmethyl)propyl] carbamate; phenylmethyl [2R-hydroxy-3- [[(1,1- dimethyl)amino] sulfonyl] (2-methylpropyl)amino] -1S- (phenylmethyl)propyl] carbamate; phenylmethyl [2R-hydroxy-3- [ [methylamino) sulfonyl] (2- methylpropyl)amino] -IS- (phenylmethyl)propyl] carbamate; phenylmethyl [2R-hydroxy-3- [ [ (methylethyl)amino] - sulfonyl] (2-methylpropyl)amino] -IS- (phenylmethyl)propyl] carbamate; phenylmethyl [2R-hydroxy-3- [ [phenylamino] sulfonyl] (2- methylpropyl)amino] -IS- (phenylmethyl)propyl] carbamate; phenylmethyl [2R-hydroxy-3- [ [cyclohexylaminoj sulfonyl] (2- methylpropyl)amino] -IS- (phenylmethyl)propyl] carbamate; or phenylmethyl [2R-hydroxy-3- [[ (1-pyrrolidinyl)amino] - sulfonyl] (2-methylpropyl)amino] -IS- (phenylmethyl)propyl] carbamate.

Inventors: DECRESCENZO GARY A, GETMAN DANIEL P, MUELLER RICHARD A, SUN ERIC T, TALLEY JOHN J, VAZQUEZ MICHAEL L, DECRESCENZO, GARY, A., GETMAN, DANIEL, P., MUELLER, RICHARD, A., SUN, ERIC, T., TALLEY, JOHN, J., VAZQUEZ, MICHAEL, L.
Applicants: DECRESCENZO GARY A, GETMAN DANIEL P, MONSANTO CO, MUELLER RICHARD A, SEARLE & CO, SUN ERIC T, TALLEY JOHN J, VAZQUEZ MICHAEL L, DECRESCENZO, GARY, A., G.D. SEARLE & CO., GETMAN, DANIEL, P., MUELLER, RICHARD, A., SUN, ERIC, T., TALLEY, JOHN, J., THE MONSATO COMPANY, VAZQUEZ, MICHAEL, L.
Application year: 1993
Main classification: C07C307
IPC codes: A61K38, C07C307, C07D215, C07D295, C07K5