AMINO ACID DERIVATIVES AS PAF-RECEPTOR ANTAGONISTS

Abstract: Compounds of general formula (I), wherein W represents pyrid-3-yl, benzimidazol-1-yl, imidazo(4,5-c)pyridin-1-yl, imidazo(4,5-c)pyridin-3-yl and imidazo(4,5-c)pyridin-5-yl optionally substituted by alkyl; Z represents: a) a divalent alkanediyl, alkenediyl or alkynediyl group, b) a -(CH2)qU(CH2)r- group, optionally substituted, q is an integer from 0-3, r is an integer from 0-3 and U is -O-, -S- or a furandiyl, tetrahydrofurandiyl, thiophenediyl, tetrahydrothiophenediyl, thiazolediyl, tetrahydrothiazolediyl, piperazinediyl, piperidinediyl, cyclopentanediyl, cyclohexanediyl, cycloheptenediyl or benzenediyl group; or c) a ( alpha ) group wherein m is an integer from 0-3, X is -O-, -S- or -CH2- and each of R<4> and R<5> is independently hydrogen or alkyl; Q represents a carbonyl, thiocarbonyl or sulphonyl group or a bond; B represents: a) a -VR<8> group wherein V is -C(=O)-, -C(=O)O-, -CH2O-, -CH2OC(=O)-, -C(=S)-, -CH2OC(=O)NH-, -C(=S)O-, -CH2S-, -C(=O)NHSO2- or -SO2NHC(=O)-; b) a -CH2NR<9>R<10> group or a -CONR<9>R<10> group; c) a group Y where Y is a 5- or 6-membered heterocyclic ring; d) a group -CH2-Y or C(=O)NHY; are antagonists of platelet activating factor (PAF).

Description: AMINO ACID DERIVATIVES AS PAF-RECEPTOR ANTAGONISTS This invention relates primarily to novel substituted amino acid derivatives that possess pharmaceutical activity as antagonists of PAF. Platelet activating factor (PAF) is a bioactive phospholipid which has been identified as 1 -O -hexadecyl/octadecyl-2-acetyl-^-glycery 1-3 -phosphoryl choline. PAF is released directly from cell membranes and mediates a range of potent and specific effects on target cells resulting in a variety of physiological responses which include hypotension, thrombocytopenia, bronchoconstriction, circulatory shock, and increased vascular permeability (oedema/erythema). It is known that these physiological effects occur in many inflammatory and allergic diseases and PAF has been found to be involved in a number of such disorders including asthma, endotoxin shock, adult respiratory distress syndrome, glomerulonephritis, immune regulation, transplant rejection, gastric ulceration, psoriasis, and cerebral, myocardial and renal ischemia. Thus the compounds of the invention, by virtue of their ability to antagonise the actions of PAF, should be of value in the treatment of any of the above conditions and any other conditions in which PAF is implicated (e.g. embryo implantation). Compounds that have been disclosed as possessing activity as PAF antagonists include compounds which are structurally related to the PAF molecule such as glycerol derivatives (EP-A-0238202), and heterocyclic compounds such as 5- oxy derivatives of tetrahydrofuran (US-4,888,337) and 2,5-diaryl tetrahydrofurans (EP-A-0144804). Recently a more potent 2,5-diaryl tetrahydrofuran derivative, (/rα/2- -2-(3-methoxy-5-methylsulphonyl-4- propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989) has been disclosed (EP-A-0199324). In our International patent application no. WO 91/17157 we disclose a series of γ-butyrolactol derivatives as PAF antagonists. The compounds of WO 91/17157 differ from the 5-oxy derivatives of tetrahydofuran described in US-4,888,337 and from the 2,5-diaryl tetrahydrofurans such as L-659,989, in that they feature an appended heterocycle with an unsubstituted sp 2 nitrogen atom. There are a number of other PAF antagonists, in addition to those of WO 91/17157, for which the presence of a heterocyclic sp 2 nitrogen atom appears to be an important requirement for activity (Whittaker, M., Curr. Opin. Thera. Patents 2(5), 583- 623 (1992)). For the compounds of the present invention the presence of a heterocyclic group possessing an unsubstituted sp 2 nitrogen atom is also a requirement for PAF antagonist activity. However, the compounds of the present invention differ from the other PAF antagonists refered to above in that they are amino acid derivatives. The present invention provides novel and useful substituted amino acid derivatives and their pharmaceutically acceptable acid addition salts, and pharmaceutical uses thereof as PAF antagonists. According to a first aspect of the invention there is provided a compound of general formula I: wherein: W represents pyrid-3-yl, benzimidazol-1-yl, imidazo[4,5-c]pyridin-l-yl, imidazo[4,5-c]pyridin-3-yl and imidazo[4,5-c]pyridin-5-yl optionally substituted with one or more -C1-C6 alkyl substituents; Z represents: a) a divalent alkanediyl, alkenediyl or alkynediyl group from 2 to 12 carbon atoms which may be a straight or branched-chain provided that, when Z represents a branched chain at least two carbon atoms separate W from the group Q, wherein the said group is either unsubstituted or substituted by one or more substituents selected from hydroxy, -OCi-C alkyl, -SCι-C alkyl and halo; or b) a -(CH2)qU(CH-2)r group, optionally substituted by one or more substituents selected from hydroxy, -OCi-Cβ alkyl, halo and nitrile, wherein q is an integer from 0-3, r is an integer from 0-3 and. U is -0-, -S- or a furandiyl, tetrahydrofurandiyl, thiophenediyl, tetrahydrothiophenediyl, thiazolediyl, tetrahydrothiazolediyl, piperazinediyl, piperidinediyl, cyclopentanediyl, cyclohexanediyl, cycloheptenediyl or benzenediyl group (provided that, when U is a 1,4-benzenediyl group q is not an integer of 1); or c) a 1 (CH2) m CR R 5 - group wherein m is an integer from 0-3, X is -0-, -S- or -CH2- and each of R4 and R5 is independently hydrogen or -C1-C6 alkyl; Q represents a carbonyl, thiocarbonyl or sulphonyl group or a bond Rl represents hydrogen, -Ci-Cβ alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -COCl- C6 alkyl, -CO2C1-C6 alkyl, -(CO2C1-C6 alkyl)phenyl, -(C1-C6 alkyl)C02Cι - Cβ alkyl, -(C1-C6 alkyl)phenyl, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl or phenyl optionally substituted by one or more substituents selected from -Ci-Cβ alkyl, -OC1-C6 alkyl, halogen, -CF3 and -CN; R2 represents hydrogen, halogen, -Ci-C alkyl optionally substituted by one or more halogen atoms, -C2-C6 alkenyl, -C2-C6 alkynyl, -(Cj-C6 alkyl)C02Cι-C6 alkyl, -(C1-C6 alkyl)SCι-C6 alkyl, -(C1-C6 alkyl)OCι-C6 alkyl, -(Cι -C 6 alkyl)N(Cι-C6 alkyl)2, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl, -(C1-C6 alkyl)C3-C8 cycloalkyl, -(C1 -C6 alkyl)C4-C8 cycloalkenyl, -(Cχ -C6 alkyl)OC3-C8 cycloalkyl, -(C1 -C6 alkyl)OC4-C8 cycloalkenyl, -(C1 -C6 alkyl)SC3-C8 cycloalkyl, -(Cj-Cό alkyl)SC4-C8 cycloalkenyl, a side chain of a naturally occurring amino acid, a group -D or -(Cj-Cβ alkyl)OD wherein D is a group wherein n is an integer from 0 to 3, and each of R6 and R? is independently hydrogen, -Ci-C alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, halogen, -CN, -CO2H, -CO2C 1 -C6 alkyl, -CONH2, -CONHC1-C6 alkyl, -CON(Cι-C6 alkyl)2, -CHO, -CH 2 OH, -CF3, -OC1-C6 alkyl, -SC1-C6 alkyl, -SOC1-C6 alkyl, -SO2C1 -C6 alkyl, -NH2 or -NHCOMe; or R ! together with R2 and the atoms to which they are attached form a 5 to 8 membered nitrogen-containing heterocyclic ring; R3 represents hydrogen or halogen; B represents: a) a -VR8 group wherein V is -C(=0)-, -C(=0)0-, -CH2O-, -CH2θC(=0)-, -C(=S)-, -CH20C(=0)NH-, -C(=S)0-, -CH2S-, -C(=0)NHSθ2- or -S02NHC(=0)-; and R8 is hydrogen, -C1-C18 alkyl, -C2-CI8 alkenyl, -C2-C18 alkynyl, -(C1-C6 alkyl)OCι-C 6 alkyl, -(Cι-C 6 alkyl)SCι-C6 alkyl, -(Cι-C 6 alkyl)0(Cι-C6 alkyl)OCι -C_ alkyl, -C3-C cycloalkyl, -C4-C8 cycloalkenyl or pyridyl, (any of which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, nitro, nitrile or carboxyl), -C1-C4 perfluoroalkyl, a group -D as defined above or a -(C1-Q5 alkyl)OD group wherein. D is as defined above; b) a -CH2NR9R10 group or a -CONR9R10 gr0 up wherein each of R9 and RlO i s independently hydrogen, -C1-C18 alkyl, -C2-C18 alkenyl, -C2-CI8 alkynyl, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl, pyridyl (any of which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, nitro, nitrile or carboxyl) or a group -D as defined above or 9 and RlO together with the nitrogen atom to which they are attached form a 5 to 8 membered nitrogen- containing heterocyclic ring; c) a group Y where Y is a 5- or 6-membered heterocyclic ring containing one or more heteroatoms selected from nitrogen, oxygen and sulphur and the ring may be optionally substituted with one or more substituents selected from -C1-C6 alkyl, -OC1-C6 alkoxy, halogen, -CF3 and -CN; or d) a group -CH2-Y or C(=0)NHY; where Y is as defined above; or a pharmaceutically or veterinarily acceptable acid addition salt or hydrate thereof. Hereafter in this specification the term "compound" includes "salt" or "hydrate" unless the context requires otherwise. As used herein the term "halogen" or its abbreviation "halo" means fluoro, chloro, bromo or iodo. As used herein the term "C1-C6 alkyl" refers to straight chain or branched chain hydrocarbon groups having from one to six carbon atoms. Illustrative of such alkyl groups are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert- butyl, pentyl, neopentyl and hexyl. As used herein the term "Cl-Cl8 alkyl" refers to straight chain or branched chain hydrocarbon groups having from one to eighteen carbon atoms. Illustrative of such alkyl groups are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, neopentyl, hexyl, decyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl and octadecyl. From one to six carbon atoms may be preferred. As used herein the term "C2-C6 alkenyl" refers to straight chain or branched chain hydrocarbon groups having from two to six carbon atoms and having in addition one double bond, of either E or Z stereochemistry where applicable. This term would include for example, vinyl, 1-propenyl, 1- and 2-butenyl and 2- methyl-2-propenyl. As used herein the term "C2-C18 alkenyl" refers to straight chain or branched chain hydrocarbon groups having from two to eighteen carbon atoms and having in addition one or more double bonds, of either E or Z stereochemistry where applicable. This term would include for example, vinyl, 1-propenyl, 1- and 2- butenyl, 2-methyl-2-propenyl, geranyl, and farnesyl. From two to six carbon atoms may be preferred. As used herein the term "C2-C6 alkynyl" refers to straight chain or branched chain hydrocarbon groups having from two to six carbon atoms and having in addition one triple bond. This term would include for example, ethynyl, 1- propynyl, 1- and 2-butynyl, 2-methyl-2-propynyl, 2-pentynyl, 3-pentynyl, 4- pentynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl and 5-hexynyl. As used herein the term "C2-C18 alkynyl" refers to straight chain or branched chain hydrocarbon groups having from two to six carbon atoms and having in addition one triple bond. This term would include for example, ethynyl, 1- propynyl, 1- and 2-butynyl, 2-methyl-2-propynyl, 2-pentynyl, 3-pentynyl, 4- pentynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 10-undecynyl, 4-ethyl-l- octyn-3-yl, 7-dodecynyl, 9-dodecynyl, 10-dodecynyl, 3-methyl-l-dodecyn-3-yl, 2- tridecynyl, 11-tridecynyl, 3-tetradecynyl, 7-hexadecynyl and 3-octadecynyl. From two to six carbon atoms may be preferred. As used herein, the term "C1-C4 perfluoroalkyl" refers to straight chain or branched chain groups having from one to four carbon atoms and substituted by more than one fluorine atom. This term would include for example, trifluoromethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, 3,3,3-trifluoro-n-propyl, sexafluoro-i-propyl, septafluoro-n-propyl, septafluoro-i-propyl, 4,4,4-trifluoro- n-butyl, nonafluoro-n-butyl, nonafluoro-sec-butyl and nonafluoro-i-butyl. As used herein the term "OC1-C6 alkyl" refers to straight chain or branched chain alkoxy groups having from one to six carbon atoms. Illustrative of such alkoxy groups are methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy, tert-butoxy, pentoxy, neopentoxy and hexoxy. As used herein the term "SC1-C6 alkyl" refers to straight chain or branched chain alkylthio groups having from one to six carbon atoms. Illustrative of such alkyl groups are methylthio, ethylthio, propylthio, isopropylthio, butylthio, isobutylthio, sec-butylthio, tert-butylthio, pentylthio, neopentylthio and hexylthio. As used herein, the term "C3-C8 cycloalkyl" refers to an alicyclic group having from 3 to 8 carbon atoms. Illustrative of such cycloalkyl groups are cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. As used herein, the term "C4-C8 cycloalkenyl" refers to an alicyclic group having from 4 to 8 carbon atoms and having in addition one or more double bonds. Illustrative of such cycloalkenyl groups are cyclopentenyl, cyclohexenyl, cycloheptenyl and cyclooctenyl. As used herein, the term "side chain of a naturally occurring amino acid" includes the side chains of alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamic acid, glycine, histidine, 5-hydroxylysine, 4-hydroxyproline, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, -aminoadipic acid, -amino-n-butyric acid, 3,4- dihydroxyphenylalanine, homoserine, α-methylserine, ornirhine, pipecolic acid, and thyroxine. The amino acid side chains may be protected; for example the carboxyl groups of aspartic acid, glutamic acid and α-aminoadipic acid may be esterified (for example as a C1-C6 alkyl ester), the amino groups of lysine, ornithine, 5-hydroxylysine, 4-hydroxyproline may be converted to amides (for example as a COC1-C6 alkyl amide) or carbamates (for example as a C(=0)OCl-C6 alkyl or C(=0)OCH2Ph carbamate), the hydroxyl groups of 5-hydroxylysine, 4-hydroxyproline, serine, threonine, tyrosine, 3,4-dihydroxyphenylalanine, homoserine, α-methylserine and thyroxine may be converted to ethers (for example a C1-C6 alkyl or a (C1-C6 alkyl)phenyl ether) or esters (for example a C(=0)Ci-C6 alkyl ester) and the thiol group of cysteine may be converted to thioethers (for example a C1 -C6 alkyl thioether) or thioesters (for example a C(=0)Cl-C6 alkyl thioester). The stereochemistry at the carbon atom to which the amino acid side chain is attached may be either D or L. As used herein, the term "nitrogen-containing heterocyclic ring" refers to an aromatic or alicyclic ring comprising one or more nitrogen atoms and optionally one or more other heteroatoms. Illustrative of such rings are pyrrolidine, piperidine, hexamethyleneimine, heptamethylenimine, morpholine and piperazine. In compounds of this invention, the presence of several asymmetric carbon atoms gives rise to diastereoisomers, each of which consists of two enantiomers, with the appropriate R or S stereochemistry at each chiral center. The invention is understood to include all such diastereoisomers, their optically active enantiomers and mixtures thereof. The term "pharmaceutically or veterinarily acceptable acid addition salt" refers to a salt prepared by contacting a compound of formula (I) with an acid whose anion is generally considered suitable for human or animal consumption. Examples of pharmaceutically and/or veterinarily acceptable acid addition salts include the hydrochloride, sulphate, phosphate, acetate, propionate, lactate, maleate, succinate and tartrate salts. It is considered that the main structural features of compounds of general formula I that are particularly significant in providing their PAF antagonist activity, are the sp 2 nitrogen heterocycle (W group) and the subunit (i) The linkage -Z- is considered to function as a spacer element, separating the sp 2 nitrogen heterocycle from the amino acid subunit. The nature or identity of the linkeage -Z- is therefore not thought to be particularly critical and any of the wide range of -Z- groupings specified above may be used with retention of PAF antagonist activity. Likewise, since the presence of the subunit (i) appears to be crucial for retention of PAF antagonist activity. There may be considerable variation of the substituent groups Rl, and B with out loss of such activity. Any of the the wide range of substituents Rl and B defined above may be used with retention of PAF antagonist activity. Of the sp 2 nitrogen heterocycles present in compounds described in our previous patent applications (WO 90/09997, WO 91/17157, WO 92/03422 and WO 92/03423) it is considered that those which are particularly prefered elements of the compounds of this invention are those specified above in relation to general formula I. However, it is expected that PAF antagonist activity may be found in compounds analogous to those of general formula I above, wherein W is a different sp 2 nitrogen heterocycle. The variety of sp 2 nitrogen heterocycles that could provide PAF antagonist activity include those disclosed in our patent application WO 91/17157 and those recently described by Whittaker (Whittaker, M., Curr. Opin. Thera. Patents 2(5), 583-623 (1992)) and Cooper (Cooper, K„ et al., J. Med. Chem. 35(17), 3115-3129 (1992)). The exact nature of the interaction of the sp 2 nitrogen heterocycle and the receptor has not been determined, but it would appear that it is important for the heterocycle to possess at least one unsubstituted sp 2 nitrogen atom within the heterocyclic ring. Preferred compounds include those in which, independently or in any compatible combination; W represents pyrid-3-yl, 2-methylbenzimidazol-l-yl, 2-methylimidazo[4,5- c]pyridin-l-yl, 2-methylimidazo[4,5-c]pyridin-3-yl, imidazo[4,5-c]pyridin-5-yl and 2-methylimidazo[4,5-c]pyridin-5-yl; Z represents a) an alkanediyl having from 3 to 11 carbon atoms (for example propylene, 2-hydroxypropylene, 1-methylpropylene, 1,1-dimethylpropylene, butylene, 1-methylbutylene, 1,1-dimethylbutylene, 3-hydroxybutylene, pentylene, 1-methylpentylene, 1,1-dimethylpentylene, 4-hydroxypenylene, 4- methoxypentylene, hexylene, 1,1-dimethylhexylene, heptylene, 1- methylheptylene, 1,1 -dime thy Iheptylene, octylene, 1,1-dimethyloctylene, nonylene, decylene, undecylene) group, an alkenediyl (for example prop -2- enylene, pent-3-enylene hex-5-enylene) group or an alkynediyl (for example prop-2-ynylene, l-methylprop-2-ynyIene, but-3-ynylene, pent-4-ynylene and hex-5-ynylene) group, or; b) a -(CH2)qU(CH2)r group, optionally substituted by nitrile, wherein; U represents -0-, -S- or a tetrahydrofurandiyl, furandiyl, a thiophenediyl, a piperidinediyl, a piperazinediyl or a benzenediyl group; q represents an integer of 0, 1, or 2 (provided that, when U is a 1,4-benzenediyl group q is not an integer of 1); r represents an integer of 0; R- represents a hydrogen atom, a -Cl-C6 alkyl (for example methyl, ethyl) group, a -C2-C6 alkenyl (for example allyl) group, a -CO2C1 -C6 alkyl (for example ethoxy carbonyl) group or a -( -C6 alkyl)C02Cl-C6 alkyl (for example a ethoxycarbonylmethyl or a t-butyloxycarbonylmethyl) group; R2 represents a -C1 -C6 alkyl (for example methyl, isopropyl, n-butyl, isobutyl or 2-methylpropyl) group, a -C2-C6 alkenyl (for example allyl) group, a -(Ci-Cg alkyl)SCχ-C6 alkyl (for example methylthioethylene) group, the side chain of a naturally occurring amino acid (for example the side chain of tryptophan), a group -D or a -( -C6 alkyl)OD group; n represents an integer of 0 or 1; R6 represents a hydrogen atom or a -OCi-C alkyl (for example methoxy) group; R7 represents a hydrogen atom; R3 represents a hydrogen atom; when R2 represents the side chain of a naturally occurring amino acid, particularly leucine, wherein the stereochemistry of the carbon atom to which R2 and R3 are attached is the same as, or the opposite to, that of the naturally occurring amino acid; B represents a -VR& group, a -CONR^RIO group or a group Y wherein: V represents a -C(=0)0- group, a -CH2θC(=0)- group, a -CH2O- group, a -CH20C(=0)- group or a -CH2θC(=0)NH- group; R8 represents a hydrogen atom, -Cl-Cl8 alkyl (for example methyl, ethyl, n- propyl, i-propyl, n-butyl, pentyl, hexyl, octyl, decyl, dodecyl, pentadecyl, hexadecyl, heptadecyl and octadecyl) group, a -C2-CI8 alkenyl group (for example allyl), a -(C1-C6 alkyl)0(Cι-C6 alkyl)OCι-C6 alkyl (for example a 2- (2-ethoxyethoxy)ethyl) group, a pyridyl (for example a 2-pyridyl) group, a group D or a -(C1-C6 alkyl)OD group; R9 is a pyridyl (for example 2-pyridyl) group; R.10 is a hydrogen atom; Y is a pyrazinyl (for example 2-pyrazinyl) group or a oxadiazolyl (for example a I,2,4-oxadiazol-5-yl) group; Particularly preferred compounds include those in which, independently or in any compatible combination; W represents pyrid-3-yI, 2-methylbenzimidazol-l-yl, 2-methylimidazo[4,5- c]pyridin-l-yl, 2-methylimidazo[4,5-c]pyridin-3-yI and 2-methylimidazo[4,5- c]pyridin-5-yl; Z represents an alkanediyl ((for example propylene, 2-hydroxypropylene, 1- methylpropylene, 1,1-dimethylpropylene, butylene, 1-methylbutylene, 1,1- dimethylbutylene, 3 -hydroxy butylene, pentylene, 1-methylpentylene, 1,1- dimethylpentylene, 4-methoxypentylene, hexylene, 1,1-dimethylhexylene, heptylene, 1-methylheptylene, 1,1-dimethylheptylene, octylene, 1,1- dimethyloctylene, nonylene, decylene, undecylene)) group or a -(CH2)nU(CH2)r (for example a group; R! represents a hydrogen atom, a -C1-C6 alkyl (for example methyl, ethyl) group, a -C2-C6 alkenyl (for example allyl) group, or a -CO2C1-C6 alkyl (for example ethoxy carbonyl) group; Q represents a carbonyl or sulphonyl group; R3 represents the side chain of the amino acid leucine; Exemplary compounds include: 1. (A) N-6-(2-Methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester, (B) N-6-(2-Methylimidazo[4,5-c]pyridm-l-yl)hexanoyl-L-leucine ethyl ester, 2. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-D-leucine ethyl ester, 3. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-phenylalanine ethyl ester, 4. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine propyl ester, 5. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-norleucine ethyl ester, 6. N-6-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)hexanoyl-0-benzyl-L-serine methyl ester, 7. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2-methylhexanoyl-L-leucine ethyl ester, 8. N-6-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)-2,2-dimethylhexanoyl-L-leucine ethyl ester, 9. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)-5-hydroxyhexanoyl-L-leucine ethyl ester, 10. N-6-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)hexanoy 1-L- leucine hexadecyl ester, 11. (A) N-4-(2-Methylimidazo[4,5-c]pyridin-3-yl)butanoyl-L-leucine ethyl ester, (B) N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine ethyl ester, (C) N-4-(2-Methylimidazo[4,5-c]pyridin-5-yl)butanoyl-L-leucine ethyl ester, 12. N-4-(2-Methylimidazo[4,5-c3pyridin-l-yl)butanoyl-L-leucine methyl ester, 13. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-0-methyl-L-tyrosine ethyl ester, 14. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)butanoyl-L-methionine ethyl ester, 15. N-4-(2-Methylimidazo[4,5-c]pyridin-l -yl)butanoyl-L-norleucine n-butyl ester, 16. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethylbutanoyl-L-leucine ethyl ester, 17. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)-3-hydroxybutanoyl-L-Ieucine ethyl ester, 18. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-valine ethyl ester, 19. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine hexyl ester, 20. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine decyl ester, 21. N-3-(2-Methylbenzimidazol-l-yl)propylsulphony 1-L-leucine ethyl ester, 22. N-4-(2-Methylimidazo [4,5-c]pyridin- 1 -yl)propylsulphonyl-L-alanine ethyl ester, 23. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-isoleucine ethyl ester, 24. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-norleucine ethyl ester, 25. N-4-(2-Methylimidazo [4 ,5-c]py ridin- 1 -yl)propyIsulphonyl-L-methion-ne ethyl ester, 26. N-4-(2-Methylimidazo[4,5-c]pyridin- l-yl)propylsuIphonyl-L-leucine i- propyl ester, 27. N-4-(2-Methy limidazo [4 ,5-c]pyridin- 1 -yl)propylsuIphony 1-L-leucine pentyl ester, 28. N-4-(2-Methylimidazo[4,5-c]pyridin- l-yl)propylsulphonyl-L-Ieucine octyl ester, 29. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine dodecyl ester, 30. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine pentadecyl ester, 31. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine hexadecyl ester, 32. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine octadecyl ester, 33. (A) N-4-(2-Methylimidazo[4,5-c]pyridin-3-yl)propylsulphonyl-L-leucinyl ethyl ether, (B ) N-4-(2-Methylimidazo[4,5-c]pyridiiι- 1 -yl)propylsuIphonyl-L-Ieucinyl ethyl ether, (C) N-4-(2-Methylimidazo[4,5-c]pyridin-5-yl)propylsulphonyl-L-leucinyl ethyl ether, 34. N-4-(2-Methylimidazo [4,5-c]pyridin-l -yl)propylsulphonyl-L-leucinyl methyl ether, 35. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucinyl octyl ether, 36. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucinyl hexadecyl ether, 37. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -y l)propylsulphonyl-L-leucinyl benzyl ether, 38. N-4-(2-Methy limidazo [4, 5-c]pyridin- 1 -yl)propylsulphonyl-L-leucinyl propionate, 39. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucinyl octadecanoate, 40. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -y l)propy lsulphonyl-L-leucinyl N'- ethyl carbamate, 41. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucinyl N'- benzyl carbamate, 42. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -y l)propylsulphonyl-L-leucinyl N'-2- pyridy lcarbamate , 43. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucinyl N- octadecylcarbamate, 44. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-l-(3-ethyl- l,2,4-oxadiazol-5-yl)-3-methylbutylamine, 45. (A) N-5-(2-Methylimidazo[4,5-c]pyridin-3-yl)pentanoyl-L-leucine ethyl ester, (B) N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-L-leucine ethyl ester, 46. N-5-(2-Methylimidazo[4,5-c]pyridin l-yl)pentanoyl-L-leucine i-propyl ester, 47. N-5-(2-Methylimidazo[4,5-c]pyridin 1 -yl)pentanoyl-0-methyl-L-tyrosine ethyl ester, 48. N-5-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)pentanoyl-D,L-allylglycine ethyl ester, 49. N-5-(2-Methylimidazo[4,5-c]pyridin- l-yl)pentanoyl-L-norleucine allyl ester, 50. N-5-(2-Methylimidazo[4,5-c]pyridin- l-yl)-2-methylpentanoyl-L-leucinyl ethyl ether, 51. N-5-(2-Methylimidazo[4,5-c]pyridin l-yl)-2,2-dimethylpentanoyl-L-leucine 2-benzoxyethylethyl ester, 52. N-5-(2-Methylimidazo[4,5-c]pyridiιι 1 -yl)-3-hydroxypentanoyl-L-leucine 2- (2-ethoxyethoxy)ethyl ester, 53. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-l-(3-methyl-l,2,4- oxadiazol-5-yl)-3-methylbutylamine, 54. N-5-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)pentanoyl- 1 -(6-ethylpyrazin-2- yl)-3 -methylbutylamine, 55. N-5-(2-Methylimidazo [4 ,5-c]pyridin- 1 -yl)pentanoyl-L-leucinyl N'-ethyl- carbamate, 56. (A) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L- leucine ethyl ester, (B) N-Methyl-N-6-(2-methylirnidazo[4,5-c]pyridin-l-yl)hexanoyl-L- leucine ethyl ester, (C) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-5-yl)hexanoyl-L- leucine ethyl ester, 57. (A) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L- isoleucine allyl ester, (B) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- isoleucine allyl ester, (C) N-Methy l-N-6-(2-methy limidazo [4,5-c]pyridin-5-yl)hexanoyl-L- isoleucine allyl ester, 58. (A) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridiii-3-yl)hexanoyl-L- leucinyl ethyl ether, (B) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- leucinyl ethyl ether, (C) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-5-yl)hexanoyl-L- leucinyl ethyl ether, 59. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucinyl hexadecyl ether, 60. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-phenyl- alaninyl ethyl ether, 61. N-Methyl-N-6-(2-methy limidazo [4,5-c]pyridin- 1 -yl)hexanoy 1-L-leucinyl 4- methoxybenzyl ether, 62. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-norleucinyl ethyl ether, 63. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-0-benzyl-L- serinyl ethyl ether, 64. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)-2-methylhexanoyl-L- leucinyl ethyl ether, 65. N-Ethoxycarbonyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- leucinyl ethyl ether, 66. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin -yl)-5-methoxyhexanoyl-L- leucinyl ethyl ether, 67. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin -yl)hexanoyl-l-(3-ethyl- l,2,4-oxadiazol-5-yl)-3-methylbutylamine, 68. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin -yl)butanoyl-L-leucine ethyl ester, 69. N-Allyl-N-4-(2-methylimidazo[4,5-c]pyridin-l- yl)butanoyl-L-leucine i- propyl ester, 70. N-Methyl-N-4-(2-methylimidazo[4,5-c]ρyridin -yl)butanoyl-L-leucinyl ethyl ether, 71. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)-2-methylbutanoyl-L- leucinyl ethyl ether, 72. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin -yl)pentanoyl-L-leucine ethyl ester, 73. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin -yl)pentanoyl-L-leucinyl ethyl ether, 74. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)-2-methylpentanoyl-L- leucinyl ethyl ether, 75. N-Methyl-N-5-(2-methy limidazo [4,5-c]pyridin -y 1 )pentanoy 1-L-leucinyl hexadecyl ether, 76. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L- leucine ethyl ester, 77. N-Methyl-N-3-(2-methy limidazo [4,5-c]pyridin- -yl)propylsulphonyl-L- leucine i-propyl ester, 78. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L- leucinyl ethyl ether, 79. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L- leucinyl hexadecyl ester, 80. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin -yl)propylsulphonyl-l-(3- ethyl- 1 ,2,4-oxadiazol-5-yl)-3 -me thy lbuty lamine 81. N-Methy l-N-4-(2-methy limidazo [4,5-c]pyridin- -yl)butylsulphonyl-L- leucine ethyl ester, 82. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)butylsulphonyl-L- leucinyl ethyl ether, 83. N-Methy l-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)butylsulphonyl-L- leucinyl heptadecyl ether, 84. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)pentylsulphonyl-L- leucine ethyl ester, 85. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin-l-yl)pentylsulphonyl-L- leucine i-propyl ester, 86. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin-l-yl)pentylsulphonyl-L- leucinyl ethyl ether, 87. (A) N-8-(2-Methylimidazo[4,5-c]pyridin-3-yl)octanoyl-L-leucine ethyl ester, (B) N-8-(2-Methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine ethyl ester, (C) N-8-(2-Methylimidazo[4,5-c]pyridin-5-yl)octanoyl-L-leucine ethyl ester, 88. N-8-(2-MethyIimidazo[4,5-c]pyridin-l-yl)-2-methyloctanoyl-L-leucine ethyl ester, 89. N-8-(2-Methylimidazo [4,5-c]pyridin-l -yl)-2,2-dimethyloctanoyl-L-phenyl- alanine ethyl ester, 90. N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine i- propyl ester, 91. N-Methyl-N-8-(2-methy limidazo [4,5-c]pyridin- 1 -yl)octanoy 1-L-leucinyl ethyl ether, 92. N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoyl-l-(3-ethyl- l,2,4-oxadiazol-5-yl)-3-methylbutylamine, 93. N-7-(2-Methylimidazo[4,5-c]pyridin-l-yl)heptanoyl-L-leucine ethyl ester, 94. N-Methyl-N-7-(2-methylimidazo[4,5-c]pyridin-l-yl)heptanoyl-L-leucinyl ethyl ether, 95. N-Methyl-N-7-(2-methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethyl- heptanoyl-L-leucinyl ethyl ether, 96. N-Methyl-N-7-(2-methy limidazo [4,5-c]pyridin- 1 -yl)heptanoyl-L-leucinyl N'-hexadecylcarbamate, 97. N-ll-(2-Methylbenzimidazol-l-yl)undecanoyl-L-leucine ethyl ester, 98. (A) N-ll-(2-Methylimidazo[4,5-c]pyridin-3-yl)undecanoyl-L-leucine ethyl ester, (B) N-l l-(2-Methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucine ethyl ester, 99. N-9-(2-Methylimidazo[4,5-c]pyridin-l-yl)nonanoyl-L-leucine ethyl ester, 100. N-Methyl-N-9-(2-methylimidazo [4,5-c]pyridin- 1 -yl)nonanoyl-L-leucine i- propyl ester, 101. N-Methyl-N-9-(2-methyl-u-nidazo[4,5-c]pyridin-l-yl)nonanoyl-L-leucinyl ethyl ether, 102. N-Methyl-N-9-(2-methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethylnonanoyl- L-leucinyl ethyl ether, 103. N-Methy 1-N- 10-(2-methy limidazo [4 ,5-c]pyridin- 1 -y l)decanoyl-L-leucinyl ethyl ester, 104. N-Methyl-N-10-(2-methylimidazo[4,5-c]pyridin-l-yl)decanoyl-L-leucine ethyl ester, 105. N-Methyl-N-ll-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucine ethyl ester, 106. N-Methyl-N-l l-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucinyl ethyl ether, 107. N-Methyl-N-12-(2-methylimidazo[4,5-c]pyridin-l-yl)dodecanoyl-L- leucinyl ethyl ether, 108. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-D-leucine ethyl ester, 109. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- phenylalanine ethyl ester, 110. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine, 111. N-Methyl-N-6-(2-methylimidazo[4,5-c]ρyridin-5-yl)hexanoyl-L-leucine, 112. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L- isoleucine, 113. N-6-(2-Methylimidazo[4,5-c]ρyridin-l-yl)hexanoyl-L-leucine, 114. N-6-(2-Methylimidazo[4,5-c]pyridin-l -yl)hexanoyl-L-phenylalanine, 115. N-4-(2-Methy limidazo [4 ,5-c]pyridin- 1 -yl)butanoy 1-L-leucine, 116. N-4-(2-Methylimidazo[4,5-c]pyridin-l -yl)propylsulphonyl-L-methionine, 117. N-8-(2-Methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine, 118. N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l -yl)octanoyl-L-leucine, 119. N-Methyl-N-1 l-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoy 1-L- leucine, 120. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucine ethyl ester, 121. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucinyl ethyl ether, 122. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- 1 -yl)benzoyl-L-phenyl- alanine ethyl ester, 123. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucine n- butyl ester, 124. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-isoleucine ethyl ester, 125. N-Ethyl-N-4-(2-methylimidazo[4,5-c]pyridin-l -yl)benzoyl-L-leucine ethyl ester, 126. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l -yl)benzoyl-L-leucine 2- pyridyl amide, 127. N-Methyl-N-4-(2-methy limidazo [4,5-c]pyridin- 1 -yl)benzoyl-L-leucinyl N'- ethylcarbamate, 128. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leuciιιyl ethanoate, 129. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-l-(3-ethyI- l,2,4-oxadiazol-5-yl)-3-methylbutylamine, 130. N-Methy l-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester, 131. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoy 1-L-leucinyl ethyl ether, 132. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine i-propyl ester, 133. N-Ethyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester, 134. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-norleucinyl ethyl ether, 135. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-l-tetrahydrofuryl-3-methyl- butylamine, 136. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-valine ethyl ester, 137. N-Methy l-N-4-(2-(3 -pyridyl)ethyl)benzoyl-N'-methyl-L-tryptophan ethyl ester, 138. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-0-benzyI-L-serine ethyl ester, 139. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-isoleucinyl ethyl ether, 140. N-4-(3-Pyridylcyanomethyl)piperazinecarbonyl-L-leucine ethyl ester, 141. N-4-(3-Pyridylcyanomethyl)piperazinecarbonyl-L-leucine ethyl ester, 142. N-Methy l-N-4-(3 -pyridylcy anomethyl)piperazinecarbonyl-L-leucine ethyl ester, 143. N-Methyl-N-4-(3-pyridylcyanomethyl)piperazinecarbonyl-L-leucinyl ethyl ether, 144. N-MethyI-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-leucine ethyl ester, 145. N-Methyl-N-4-(3 -pyridylcy anomethy l)piperidϊnecarbony 1-L-leucinyl ethyl ether, 146. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-leucine propyl ester, 147. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyI-L-isoleucine ethyl ester, 148. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-phenylalanine ethyl ester, 149. N-Ethyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-leucinyl ethyl ether; or a salt of such a compound. Compounds of general formula I may be prepared by any suitable method known in the art and/or by the following process, which itself forms part of the invention. According to a second aspect of the invention, there is provided a process for preparing a compound of general formula I as defined above, the process comprising: (a) treating a nitrogen heterocycle represented by general formula II w-H π wherein W is as defined in general formula I, with a suitable base (e.g. sodium hydride, potassium hydride or sodium bis(trimethylsilyl)amide), followed by a compound of general formula III wherein Z, Q, R.1, R2, R3 and B are as defined in general formula I, and L is a leaving group such as chloro, bromo, iodo, methanesulphonyloxy, p-toluenesulphonyloxy or trifluoromethanesulphonyloxy; (b) treating an amine represented by general formula IV wherein R , R2, R3, and B are as defined in general formula I, with a suitable base in an aprotic solvent followed by a halo derivative of general formula V ,z s „Hai w Q' Y wherein W, Z and Q are as defined in general formula I and Hal is a halide such as fluoro, chloro, bromo or iodo; (c) treating an amine of general formula IV with a derivative of general formula VI w - Z ^ 0H VI wherein W and Z are as defined in general formula I and Q represents a -C(=0)- group, in the presence of a coupling reagent; and (d) optionally after step (a), step (b) or step (c) converting, in one or a plurality of steps, a compound of general formula I into another compound of general formula I. The reaction of step (a) can, for preference, be conducted in an aprotic solvent, for example tetrahydrofuran, to yield compounds of general formula I. The reaction may yield an isomeric mixture, which may be separated by chromatography to yield compounds of general formula I. The reaction of step (b) can, for preference, be conducted in an aprotic solvent, for example tetrahydrofuran, to yield compounds of general formula I. Suitable bases include sodium hydride, potassium hydride or sodium bis(trimethylsilyl)amide when Q is a bond and triethylamine when Q is a carbonyl, thiocarbonyl or sulphonyl group. The coupling reagent used in the reaction of step (c) can, for preference, be tV'-dicyclohexylcarbodiimide to yield compounds of general formula I. By means of step (d), compounds of general formula I wherein B is a -Cθ2R^ group can be converted to compounds of general formula I in which B is a -CO2H group by acid or base catalysed hydrolysis in a protic solvent. Suitable acids for use in the hydrolysis include sulphuric and hydrochloric acids, whilst base hydrolysis can be catalysed with sodium or potassium hydroxide. If B represents a -Cθ2 ^ group in which R& is a benzyl group, the conversion of B from an ester to an acid can also be effected by hydrogenation in a suitable solvent, for example, a lower alcohol such as ethanol using a noble metal catalyst such as palladium or platinum. Also by means of step (d) compounds of general formula I wherein B is a -CONR9R10 group wherein R9 and R 10 are as defined in general formula I, may be prepared by the following methods; i) by treatment of a compound of general formula I wherein B is a -Cθ2H group with an amine of general formula HNR9R10 m the presence of a coupling reagent (e.g. -V,-V'-dicyclohexylcarbodiimide); ii) by treatment of a compound of general formula I wherein B is a -CO2R8 group wherein R8 is a -C1-C6 alkyl with a dimethylaluminium amide of general formula VII wherein R9 and RlO are as defined in general formula I, which is prepared in situ from trimethylaluminium and an amine of general formula HNR^RlO. Also by means of step (d) compounds of general formula I may be prepared by the treatment of a compound of general formula I wherein Rl is hydrogen with base followed by an electrophile of general formula VIII LR vπi wherein R is as defined in general formula I but is not a hydrogen atom, a phenyl or a substituted phenyl group, and L is as defined in general formula m. Electrophiles of general formula VIII are available in the art or can be prepared by procedures known to those skilled in the art. Also by means of step (d) certain compounds of general formula I wherein B is a VR8 group wherein V is -CH2O- and R^ is hydrogen may be prepared by treatment of a compound of general formula I wherein B is a VR8 group wherein V is -C(=0)0- and R^ is other than hydrogen with a suitable reducing agent (e.g. lithium aluminium hydride). Also by means of step (d) certain compounds of general formula I wherein B is a VR8 group wherein V is -CH2O- and R8 is other than hydrogen may be prepared by treatment of a compound of general formula I wherein B is a VR& group wherein V is -CH2O- and R^ is hydrogen with a suitable base in an aprotic solvent followed by an electrophile of general formula LR8 wherein R& is -C1-C18 alkyl optionally substituted by one or more halogen atoms, -C3-C18 alkenyl, -C3-CI8 alkynyl, -(C1-C6 alkyl)OCι-C6 alkyl, -(C1-C6 alkyl)SCι-C6 alkyl, -(C1-C6 alkyl)0(Cι-C6 alkyl)OCι-C6 alkyl, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl, a group -D (wherein or n is an integer of 1, 2 or 3) or a -(Ci- j alkyl)OD group and L is a leaving group as defined above. Also by means of a step (d) certain compounds of general formula I wherein B is a VR8 group wherein V is a -CH2θ(C=0)- group and Rβ is as defined in general formula I but is not hydrogen, may be prepared by treatment of a compound of general formula I wherein B is a VRβ group wherein V is a -CH2O- group and R is hydrogen with a compound of general formula LC(=0)R8 wherein L is as defined above and R8 is as defined in general formula I but is not hydrogen, in an aprotic solvent (e.g. tetrahydrofuran) in the presence of a suitable base (e.g. triethylamine). Also by means of a step (d) certain compounds of general formula I wherein B is a VR8 group wherein V is a -CH2θ(C=0)NH- group and R^ is as defined in general formula I but is not hydrogen, may be prepared by treatment of a compound of general formula I wherein B is a VR^ group wherein V is a -CH2O- group and R^ is hydrogen with a compound of general formula 0CNR8 wherein R8 is as defined in general formula I but is not hydrogen. Also by means of a step (d) certain compounds of general formula I wherein B is a l,2,4-oxadiazol-5-yl group may be prepared by treatment of a compound of general formula I wherein B is a -CO2R8 group wherein R8 is hydrogen with pentafluorophenol and a coupling agent such as N-(3-dimethylaminopropyl)-N'- ethylcarodiimide in a solvent such as dichloromethane. The resulting pentafluorophenyl ester is treated with an amide oxime of general formula IX wherein RU represents hydrogen, -C1-C6 alkyl, halogen, -CF3 or -CN, in a suitable aprotic solvent (e.g. chloroform), followed by cyclisation under Dean- Stark conditions in suitable solvent (e.g. xylene, toluene, benzene or ethyl acetate). The cyclisation may be aided by the addition of activated molecular sieves. Amide oximes of general formula IX are known in the art or may be prepared by methods analogous to those known in the art. Compounds of general formula II are known in the art or may be prepared by methods analogous to those known in the art. Compounds of general formula III may be prepared by treatment of an amine of general formula IV with an activated carboxylic, thiocarboxylic or sulphonic acid of general formula X l ^CΓ X wherein Z, and Q are as defined in general formula I, L is as defined above and L' is as defined above for L, in the presence of a suitable base (e.g. triethylamine). Amines of general formula IV and activated carboxylic, thiocarboxylic or sulphonic acids of general formula X are known in the art or may be prepared by methods known in the art. Compounds of general formula V wherein W, Z and Q are as defined in general formula I, and Hal is chloro may be prepared by the treatment of a compound of general formula VI with thionyl chloride (or oxalyl chloride). The reaction may be aided by the addition of catalytic -V,-V-dimethylformamide. Compounds of general formula VI may be prepared by the treatment of a compound of general formula II with a suitable base (e.g. sodium hydride, potassium hydride or sodium bis(trimethylsilyl)amide), followed by a compound of general formula XI Z OH L Q XI wherein Z and Q are as defined in general formula I and L is a leaving group as defined above. Compounds of general formula XI are known in the art or may be prepared by methods known in the art. The appropriate solvents employed in the above reactions are solvents wherein the reactants are soluble but which do not react with the reactants. The preferred solvents vary from reaction to reaction and are readily ascertained by one of ordinary skill in the art. Compounds of general formula III, general formula V and general formula VI are valuable intermediates in the preparation of compounds of general formula I, as are other novel compounds specifically or generically disclosed herein. According to a third aspect of the invention, there is therefore provided a compound of general formula IE. According to a fourth aspect of the invention, there is therefore provided a compound of general formula V. According to a fifth aspect of the invention, there is therefore provided a compound of general formula VL Compounds of general formula I are potentially useful as PAF antagonists. This invention therefore also relates to methods of treatment for patients (or animals including mammalian animals raised in the dairy, meat, or fur trades, or as pets) suffering from disorders or diseases which can be attributed to PAF as previously described. More specifically, the invention relates to a method of treatment involving the administration of PAF antagonists of general formula I as the active ingredient. In addition to the treatment of warm blooded animals such as mice, rats, horses, cattle, pigs, sheep, dogs, cats, etc., the compounds of the invention are effective in the treatment of humans. According to a sixth aspect of the invention there is provided a compound of general formula I for use in human or veterinary medicine particularly in the management of diseases mediated by PAF. When used as PAF antagonists, the compounds of general formula I can be used among other things to reduce inflammation and pain, to correct respiratory, cardiovascular, and intravascular alterations or disorders, and to regulate the activation or coagulation of platelets, to correct hypotension during shock, the pathogenesis of immune complex deposition and smooth muscle contractions. According to a seventh aspect of the invention there is provided the use of a compound of general formula I in the preparation of an agent for the treatment or prophylaxis of PAF-mediated diseases, and/or the treatment of inflammatory disorders such as rheumatoid arthritis, osteoarthritis and eye inflammation, cardiovascular disorder, thrombocytopenia, asthma, endotoxin shock, adult respiratory distress syndrome, glomerulonephritis, immune regulation, gastric ulceration, transplant rejection, psoriasis, allergic dermatitis, urticaria, multiple sclerosis, cerebral, myocardial and renal ischemia and any other condition in which PAF is implicated. Compounds of general formula (I) may be administered orally, topically, parenterally, by inhalation spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques. According to a eighth aspect of the invention there is provided a pharmaceutical or veterinary formulation comprising a compound of general formula I and a pharmaceutically and/or veterinarily acceptable carrier. One or more compounds of general formula I may be present in association with one or more non-toxic pharmaceutically and/or veterinarily acceptable carriers and/or diluents and/or adjuvants and if desired other active ingredients. The pharmaceutical compositions containing compounds of general formula I may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, or syrups or elixirs. Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavouring agents, colouring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example, corn starch, or alginic acid; binding agents, for example starch, gelatin or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate may be employed. Formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin, or olive oil. Aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, poiyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally- occuring phosphatide, for example lecithin, or condensation products of an alkylene oxide with fatty acids for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives, for example ethyl, or n-propyl p-hydroxybenzoate, one or more colouring agents, one or more flavouring agents, and one or more sweetening agents, such as sucrose or saccharin. Oily suspensions may be formulated by suspending the active ingredients in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavouring agents may be added to provide a palatable oral preparations. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid. Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example sweetening, flavouring and colouring agents, may also be present. Pharmaceutical compositions of the invention may also be in the form of oil-in- water emulsions. The oily phase may be a vegetable oil, for example olive oil or arachis oil, or a mineral oil, for example liquid paraffin or mixtures of these. Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally-occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol anhydrides, for example sorbitan monooleate, and condensation products of the said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening and flavouring agents. Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavouring and colouring agents. The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleaginous suspension. This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parentally acceptable diluent or solvent, for example as a solution in 1,3-butane diol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono-or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. The compounds of general formula I may also be administered in the form of suppositories for rectal administration of the drug. These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug. Such materials are cocoa butter and polyethylene glycols. For topical application to the skin compounds of general formula I may be made up into a cream, ointment, jelly, solution or suspension etc. Cream or ointment formulations that may be used for the drug are conventional formulations well known in the art, for example, as described in standard text books of pharmaceutics such as the British Pharmacopoeia. For topical applications to the eye, compounds of general formula I may be made up into a solution or suspension in a suitable sterile aqueous or non-aqueous vehicle. Additives, for instance buffers, preservatives including bactericidal and fungicidal agents, such as phenyl mercuric acetate or nitrate, benzalkonium chloride or chlorohexidine, and thickening agents such as hypromellose may also be included. Compounds of general formula I may be administered parenterally in a sterile medium. The drug depending on the vehicle and concentration used, can either be suspended or dissolved in the vehicle. Advantageously, adjuvants such as a local anaesthetic, preservative and buffering agents can be dissolved in the vehicle. Compounds of general formula I may be used for the treatment of the respiratory tract by nasal or buccal administration of, for example, aerosols or sprays which can disperse the pharmacological active ingredient in the form of a powder or in the form of drops of a solution or suspension. Pharmaceutical compositions with powder-dispersing properties usually contain, in addition to the active ingredient, a liquid propellant with a boiling point below room temperature and, if desired, adjuncts, such as liquid or solid non-ionic or anionic surfactants and/or diluents. Pharmaceutical compositions in which the pharmacological active ingredient is in solution contain, in addition to this, a suitable propellant, and furthermore, if necessary, an additional solvent and/or a stabiliser. Instead of the propellant, compressed air can also be used, it being possible for this to be produced as required by means of a suitable compression and expansion device. Dosage levels of the order of from about 0.1 mg to about 140 mg per kilogram of body weight per day are useful in the treatment of the above-indicated conditions (about 0.5 mg to about 7 g per patient per day). For example, inflammation may be effectively treated by the administration of from about 0.01 to 50 mg of the compound per kilogram of body weight per day (about 1.0 mg to about 3.5 g per patient per day). The dosage employed for the topical administration will, of course, depend on the size of the area being treated. For the eyes each dose will be typically in the range from 10 to 100 mg of the drug. The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. For example, a formulation intended for the oral administration of humans may contain from 0.5 mg to 5 g of active agent compounded with an appropriate and convenient amount of carrier material which may vary from about 5 to about 95 percent of the total composition. Dosage unit forms will generally contain between from about 1 mg to about 500 mg of an active ingredient. It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, rate of excretion, drug combination and the severity of the particular disease undergoing therapy. It has been found that the compounds of general formula I exhibit in vitro antagonistic activities with respect to PAF. Compounds of general formula inhibit PAF-induced functions in both the cellular and tissue levels by changing the PAF binding to its specific receptor site. The ability of compounds of general formula I to inhibit the binding of PAF to it ' s specific receptor binding site on human platelet plasma membranes was measured according to Example 150. The ability of compounds of general formula I to reverse the hypotension caused by an infusion of PAF in rats was measured according Example 151. The following examples illustrate the invention, but are not intended to limit the scope in any way. The following abbreviations have been used in the Examples:- DCM - Dichloromethane DMAP - 4-Dimethylaminopyridine DMF - -V,N-dimethy If ormamide TDA-1 - Tris(2-(2-methoxyethoxy)ethyl)amine THF - Tetrahydrofuran Unless otherwise stated H NMR spectra were recorded on a Bruker AC-250 spectrometer at 250 MHz using CDCI3 as a solvent and internal reference and are reported as delta ppm from TMS. Example 1 (A) N-6-(2-Methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester and (B) N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine ethyl ester (a) N-6-Bromohexanoyl-L-leucine ethyl ester A stirred suspension of L-leucine ethyl ester hydrochloride (8.38 g, 45 mmol) in dry THF (80 ml) at room temperature was treated with triethylamine (6.3 ml, 45 mmol). The reaction mixture was treated with 6-bromohexanoyl chloride (6.91 ml, 45 mmol). The reaction mixture was stirred for 4 h at room temperature and then diluted with a mixture of saturated aqueous ammonium chloride and ethyl acetate. The organic layer was separated, washed with saturated aqueous ammonium chloride, dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure to give N-6-bromohexanoyl-L-leucine ethyl ester (12.1 g, 80%) as an oil which was used for the next step without further purification. deltaH 5.94 (1H, d, J 8.1 Hz), 4.70-4.55 (1H, m), 4.16 (2H, q, J 7.2 Hz), 3.39 (2H, t, J 6.4 Hz), 2.22 (2H, t, J 7.2 Hz), 1.94-1.80 (2H, m), 1.74-1.39 (7H, m), 1.26 (3H, t, J 7.0 Hz), 0.93 (6H, d, J 5.8 Hz). (b) (A) N-6-(2-Methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester and (B) N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine ethyl ester A stirred solution of 2-methylimidazo[4,5-c]pyridine (3.0 g, 22.5 mmol) in dry THF (60 ml) at room temperature was treated with sodium hydride (900 mg, 22.5 ml). The mixmre was stirred for 1 h and the resulting white slurry treated with a solution of N-6-bromohexanoyl-L-leucine ethyl ester (22.5 mmol) in dry THF (30 ml) and stirred overnight. The reaction mixture was diluted with a mixture of saturated aqueous ammonium chloride and ethyl acetate. The organic layer was separated, washed with saturated aqueous ammonium chloride, dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure to give an oil. The crude product mixture was purified by column chromatography (silica: 5% methanol in DCM) and two of the three possible regioisomers were collected, eluting in the order; (A) N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester Pale yellow oil (0.7% yield): i.r. (CDC13) 1725, 1660 cπrl deltaH 8.73 (1H, s), 8.39 (1H, d, J 5.3 Hz), 7.58 (1H, d J 5.5 Hz), 5.94 (1H, br d, J 8.3 Hz), 4.65-4.54 (1H, m), 4.24-4.11 (4H, m), 2.63 (3H, s), 2.21 (2H, t, J 7.2 Hz), 1.90-1.32 (9H, m), 1.27 (3H, t, J 7.3 Hz), 0.93 (3H, d, J 6.0 Hz), 0.92 (3H, d, J 6.3 Hz); (B) N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine ethyl ester Pale yellow oil (0.7% yield): i.r. (CDC13) 1725, 1660 cnr* deltaH 8.97 (IH, s), 8.37 (IH, d, J 5.6 Hz), 7.24 (IH, d, 5.5 Hz), 5.92 (IH, br d, 8.2 Hz), 4.67-4.55 (IH, m), 4.18 (2H, q, J 7.1 Hz), 4.10 (2H, t, J 7.9 Hz), 2.63 (3H, s), 2.22 (2H, t, J 7.2 Hz), 1.90-1.32 (9H, m), 1.28, (3H, t, J 7.2 Hz), 0.94 (3H, d, J 5.9 Hz), 0.93 (3H, d, J 6.2 Hz). Examples 2-10 The compounds of Examples 2-10 may be prepared by the method of Example 1 employing the appropriate amino acid derivative in lieu of L-leucine ethyl ester hydrochloride as starting material and for certain compounds the appropriate substituted 6-bromohexanoyl chloride in lieu of 6-bromohexanoyl chloride. 2. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-D-leucine ethyl ester 3. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-phenylalanine ethyl ester 4. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- leucine propyl ester 5. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-norleucine ethyl ester 6. N-6-(2-Methylimidazo[4,5-c]pyridin-l -yl)hexanoyl-0-benzyl-L-serine methyl ester 7. N-6-(2-Methylimidazo[4,5-c]pyridin-l -yl)-2-methylhexanoyl-L-leucine ethyl ester 8. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethylhexanoyl-L-leucine ethyl ester 9. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)-5-hydroxyhexanoyl-L-leucine ethyl ester 10. N-6-(2-Methyhmidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine hexadecyl ester Example 11 (A) N-4-(2-Methylimidazo[4,5-c]pyridin-3-yl)butanoyl-L-leucine ethyl ester, (B) N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine ethyl ester and (C) N-4-(2-memylimidazo[4,5-c]pyridin-5-yl)butanoyl-L-leucine ethyl ester (a) 4-Bromobutanoyl-L-leucine ethyl ester 4-Bromobutanoyl-L-leucine ethyl ester was prepared by the procedure of Example 1 Step (a) employing 4-bromobutanoyl chloride in lieu of 6- bromohexanoyl chloride. Yellow oil (30% yield): i.r. (CDCI3) 2210, 1730, 1670, 1500, 1155 cm-1 deltaπ 6.34 (IH, d, J 8.2 Hz), 4.63-4.50 (IH, m), 4.14 (2H, q, J 7.1 Hz), 3.44 (2H, t, J 6.0 Hz), 2.40 (2H, t, J 7.0 Hz), 2.22-2.07 (2H, m), 1.69-1.44 (3H, m), 1.23 (3H, t,J7.1 Hz),0.90(6H, d,J5.9Hz). (b) (A) N-4-(2-Methylimidazo[4,5-c]pyridin-3-yl)butanoyl-L-leucine ethyl ester, (B) N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine ethyl ester and (C) N-4-(2-methylimidazo[4,5-c]pyridin-5-yl)butanoyl-L-leucine ethyl ester A suspension of potassium hydroxide (2.1 g, 37 mmol) and TDA-1 (4 drops) in dry acetonitrile (250 ml) under argon was stirred at room temperature for 10 min. 2-Methylimidazo[4,5-c]pyridine (5.0 g, 38 mmol) was added, and the reaction mixture heated at 80°C for 3 h, then cooled to 40°C. A solution of 4- bromobutanoyl-L-leucine ethyl ester (12.0 g, 36 mmol) in dry acetonitrile (250 ml) was added and the reaction mixture stirred at 80°C overnight and cooled to room temperature. Ethanol (100 ml) was added and the resulting slurry filtered through a short pad of celite. Column chromatography (silica: 2-8% methanol in DCM) gave three regioisomeric products eluting in the order; (A) N-4-(2-methylimidazo[4,5-c]pyridin-3-yl)butanoyl-L-leucine ethyl ester Colourless oil (2% yield): i.r. (CDC13) 2210, 1725, 1665, 1500, 1200 cm-1 deltaπ 8.69 (IH, s), 8.28 (IH, d, J 5.5 Hz), 7.48 (IH, d, J 5.6 Hz), 7.01 (IH, d, J 8.1 Hz), 4.57-4.48 (IH, m), 4.24-4.18 (2H, m), 4.12 (2H, q, J 7.1 Hz), 2.56 (3H, s), 2.32-2.21 (2H, m), 2.18-2.03 (2H, m), 1.67-1.38 (3H, m), 1.21 (3H, t, J 7.5 Hz), 0.87 (3H, d, J 6.1 Hz), 0.84 (3H, d, J 6.3 Hz); deltac 173.10, 171.28, 155.13, 147.57, 141.41, 132.82, 132.14, 113.62, 61.17, 50.80, 43.25, 40.97, 31.86, 25.13, 24.78, 22.60, 21.64, 13.99, 13.58; (B) N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)butanoy 1-L-leucine ethyl ester Colourless oil (2% yield): i.r. (CDC13) 3445, 2965, 2220, 1730, 1670, 1615, 1510 cm-1 deltaH 8.74 (IH, s), 8.14 (IH, d, J 5.5 Hz), 7.65 (IH, d, J 8.0 Hz), 7.19 (IH, d, J 5.6 Hz), 4.51-4.42 (IH, m), 4.13-3.96 (4H, m), 2.46 (3H, s), 2.23-2.15 (2H, m), 2.07-1.91 (2H, m), 1.61-1.36 (3H, m), 1.34 (3H, t, J 7.1 Hz), 0.80 (3H, d, J 6.1 Hz), 0.75 (3H, d, J 6.2 Hz); deltac 172.88, 171.32, 153.32, 140.93, 140.68, 139.95, 139.41, 104.92, 59.67, 49.50, 41.64, 39.42, 30.33, 23.61, 23.42, 21.26, 20.20, 12.65, 12.21; (C) N-4-(2-methylimidazo[4,5-c]pyridin-5-yl)butanoyl-L-leucine ethyl ester Yellow oil (5% yield): i.r. (CDCI3) 2190, 1730, 1665, 1315 delta H 8.41 (IH, s), 8.12 (IH, d, J 7.7 Hz), 7.66 (IH, d, J 8.2 Hz), 7.49 (IH, d, J 6.7 Hz), 4.50-4.25 (3H, m), 4.11 (2H, q, J 7.1 Hz), 2.56 (3H, s), 2.28-2.02 (4H, m) 1.69-1.44 (3H, m), 1.19 (3H, t, J 7.0 Hz), 0.82 (3H, d, J 6.2 Hz), 0.78 (3H, d, J 6.3 Hz) deltac 173.45, 173.14, 171.44, 155.20, 144.55, 130.30, 128.77, 111.32, 60.94, 58.18, 50.99, 39.97, 30.58, 26.93, 24.67, 22.47, 21.21, 17.67, 13.89. Examples 12-20 The compounds of Examples 12-20 may be prepared by the method of Example 11 employing the appropriate amino acid derivative in lieu of L-leucine ethyl ester hydrochloride as starting material and for certain compounds the appropriate substituted 4-bromobutanoyl chloride in lieu of 4-bromobutanoyl chloride. 12. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine methyl ester 13. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-0-methyl-L-tyrosine ethyl ester 14. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-methionine ethyl ester 15. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-norleucine n-butyl ester 16. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethylbutanoyl-L-leucine ethyl ester 17. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)-3-hydroxybutanoyl-L-leuoine ethyl ester 18. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-valine ethyl ester 19. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine hexyl ester 20. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine decyl ester Example 21 N-3-(2-Methylbenzimidazol- 1 -yl)propylsulphony 1-L-leucine ethyl ester N-3-(2-Methylbenzimidazol-l-yl)propylsulphony 1-L-leucine ethyl ester was prepared by the method of Example 1 employing 3-chloropropylsulphonyl chloride in lieu of 6-bromohexanoyl chloride and 2-methylbenzimidazole in lieu of 2-methy limidazo [4,5-c]pyridine. Colourles oil (30% yield for last step after chromatography (silica 5% methanol in DCM)): i.r. (CDC13) 1730 cm-1 deltaH (250 MHz, CDCI3) 7.73-7.64 (IH, m), 7.85-7.16 (3H, m), 5.42 (IH, d, J 9.6 Hz), 4.26 (2H, t, J 7.2 Hz), 4.21-3.98 (3H, m), 3.07-2.92 (2H, m), 2.60 (3H, s), 2.40-2.22 (2H, m), 1.90-1.70 (IH, m), 1.68-1.46 (2H, m), 1.23 (3H, t, J 7.1 Hz), 0.92 (3H, d, J 6.5 Hz), 0.90 (3H, d, J 6.6 Hz); deltac 171.58, 149.87, 140.96, 133.44, 120.96, 120.70, 117.70, 107.57, 60.44, 53.28, 49.08, 40.64, 40.48, 37.10, 23.04, 22.69, 21.35, 19.82, 12.66. Examples 22-32 The compounds of Examples 22-32 may be prepared by the method of Example 21 employing the appropriate amino acid derivative in lieu of L-leucine ethyl ester hydrochloride and 2-methylimidazo[4,5-c]pyridine in lieu of 2- methylbenzimidazole as starting materials. 22. N-4-(2-MethyIimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-alanine ethyl ester 23. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-isoleucine ethyl ester 24. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-norleucine ethyl ester 25. N-4-(2-Methylimidazo[4,5-c]pyridin- l-yl)propylsulphonyl-L-methionine ethyl ester 26. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine i-propyl ester 27. N-4-(2-Methylimidazo[4,5-c]pyridin-l -yl)propylsulphonyl-L-leucine pentyl ester 28. N-4-(2-Methy limidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucine octyl ester 29. N-4-(2-Methylimidazo[4,5-c]pyridin-l -yl)propylsulphonyl-L-leucine dodecyl ester 30. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine pentadecyl ester 31. N-4-(2-Methy limidazo [4,5 -c]pyridin- 1 -yl)propy lsulphonyl-L-leucine hexadecyl ester 32. N-4-(2-Methylimidazo[4,5-c]pyridin- l-yl)propylsulphony 1-L-leucine octadecyl ester Example 33 (A) N-4-(2-Methylimidazo [4,5-c]py ridin-3 -yl)propy lsulphony 1-L-leucinyl ethyl ether, (B) N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl ethyl ether and (C) N-4-(2-methyl-imidazo[4,5-c]pyridin-5-yl)propylsulphonyl-L- leucinyl ethyl ether (a) L-Leucinyl ethyl ether Sodium hydride (60% dispersion in oil: 4.5 g, 0.11 mol) was added to a stirred solution of L-leucinol (12.8 ml, 0.10 mol) in a mixture of dry acetonitrile (24 ml) and dry THF (200 ml) at room temperature under argon. The mixture was heated at reflux for 2 h, cooled to 55°C and ethyl iodide (8.2 ml, 0.10 mol) added carefully. The reaction mixture was heated at reflux overnight and allowed to cool to room temperature. Ice cold brine (100 ml) was added carefully and the mixture extracted with ethyl acetate (3x100 ml). The combined organic extracts were dried over anhydrous sodium sulphate, filtered and evaporated. The residue was distilled under reduced pressure to give L-leucinyl ethyl ether (4.5 g, 30%) as a colourless oil which was used directly in the next step. deltaH 3.49-3.14 (4H, m), 3.08-2.81 (2H, m), 1.73-1.50 (IH, m), 1.16-0.91 (6H, m), 0.84 (3H, d, J 6.9 Hz), 0.81 (3H, d, J 6.7 Hz). (b) (A) N-4-(2-Methylimidazo[4,5-c]pyridin-3-yl)propylsulphonyl-L-leucinyl ethyl ether, (B) N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L- leucinyl ethyl ether and (C) N-4-(2-methylimidazo[4,5-c]pyridin-5-yl)propyl- sulphonyl-L-leucinyl ethyl ether The three regioisomers were prepared by the procedure of Example 11, employing L-leucinyl ethyl ether and 3-chloropropylsulphonyl chloride as starting materials, and were separated by chromatography. (A) N-4-(2-Methylimidazo[4,5-c]pyridin-3-yl)propylsulphonyl-L-leucinyl ethyl ether Yellow oil (1% yield for last step after chromatography (silica 4% methanol in DCM)): Analysis calculated for C18H30N4O3S.O.7 H2O Requires C 54.72 H 8.01 N 14.18 Found C54.72H7.91 N 13.87 i.r. (CDC13) 3395, 2960, 2210, 1610, 1400, 1115 cm ■ 1 deltaπ (CDCI3) 8.71 (IH, s), 8.30 (IH, d, J 5.6 Hz), 7.50 (IH, d, J 5.4 Hz), 6.08 (IH, d, J 8.7 Hz), 4.34 (2H, t, J 7.5 Hz), 3.61-3.22 (5H, m), 3.12 (2H, t, J 6.9 Hz), 2.58 (3H, s), 2.36-2.19 (2H, m), 1.77-1.60 (IH, m), 1.40-1.12 (2H, m), 1.03 (3H, t, J 6.9 Hz), 0.84 (3H, d, J 6.3 Hz), 0.81 (3H, d, J 6.4 Hz); (B) N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl ethyl ether Colourles oil (1% yield): Analysis calculated for CI8H30N4O3S Requires C 56.51 H 7.91 N 14.66 Found C 56.25 H 7.86 N 14.50 i.r. (CDCI3) 2215, 1610, 1585, 1390, 1330, 1115 cm-1 deltaH 8.86 (IH, s), 8.23 (IH, d, J 5.5 Hz), 7.25 (IH, d, J 5.6 Hz), 6.26-6.11 (IH, m), 4.27 (2H, t, J 7.3 Hz), 3.63-3.24 (5H, ), 3.10 (2H, t, J 6.7 Hz), 2.57 (3H, s), 2.32-2.16 (2H, m), 1.80-1.62 (IH, m), 1.42-1.16 (2H, m), 1.07 (3H, t, J 7.0 Hz), 0.85 (3H, d, J 6.1 Hz), 0.82 (3H, d, J 6.2 Hz); (C) N-4-(2-methylimidazo [4,5-c]pyridin-5-yl)propylsuIphony 1-L-leucinyl ethyl ether H White crystalline solid (3% yield from ethyl acetate): m.p. 195°C Analysis calculated for C18H30N4O3S Requires C 56.51 H 7.91 N 14.66 Found C 56.29 H 7.81 N 14.58 i.r. (CDCI3) 2195, 1625, 1430, 1320, 1120 cm-1 deltaH (CDCI3) 8.41 (IH, s), 7.60-7.49 (2H, m), 6.74-6.58 (IH, m), 4.55-4.40 (2H, m), 3.66-3.51 (IH, m), 3.48-3.26 (4H, m), 3.09 (2H, t, J 7.1 Hz), 2.69 (3H, s), 2.51-2.36 (2H, m), 1.80-1.63 (IH, m), 1.42-1.14 (2H, m), 1.06 (3H, t, J 7.0 Hz), 0.87 (3H, d, J 6.5 Hz), 0.82 (3H, d, J 6.6 Hz). Examples 34-44 The compounds of Examples 34-44 may be prepared by the method of Example 33 employing the appropriate amino acid derivative in lieu of L-leucinyl ethyl ether as starting material. 34. N-4-(2-Methylimidazo[4,5-c]pyridin-l -yl)propylsulphonyl-L-leucinyl methyl ether 35. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl octyl ether 36. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl hexadecyl ether 37. N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucinyl benzyl ether 38. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl propionate 39. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl octadecanoate 40. N-4-(2-Methylimidazo[4,5-c]pyridin-l -yl)propylsulphonyl-L-leucinyl N'-ethyl carbamate 41. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl N'- benzyl carbamate 42. N-4-(2-Memylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl N'-2- pyridylcarbamate 43. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucinyl N- octadecylcarbamate 44. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-l-(3-ethyl-l,2,4- oxadiazoi-5-y l)-3 -methy lbutylamine Example 45 (A) N-5-(2-Methylimidazo[4,5-c]pyridin-3-yl)ρentanoyl-L-leucine ethyl ester and (B) N-5-(2-methyIimidazo[4,5-c]pyridin-l-yl)pentanoyl-L-leucine ethyl ester The compounds of Example 45 were prepared by the procedure of Example 11, utilising 5-bromopentanoyl chloride in lieu of 4-bromobutanoyl chloride, and were separated by chromatography. (A) N-5-(2-methylimidazo[4,5-c]pyridin-3-yl)pentanoyl-L-leucine ethyl ester Colourless oil (8% yield for last step after chromatography (silica: 6% methanol i DCM)): i.r. (CDCI3) 2210, 1730, 1670, 1500, 1400 cm-1 deltaH 8.62 (IH, s), 8.27 (IH, d, J 5.6 Hz), 7.46 (IH, d, J 5.1 Hz), 6.83 (IH, d, J 8.2 Hz), 4.54-4.43 (IH, m), 4.14-4.01 (4H, m), 2.52 (3H, s), 2.18 (2H, t, J 7.0 Hz), 1.86-1.35 (7H, m), 1.15 (3H, t, J 7.1 Hz), 0.81 (3H, d, J 5.9 Hz), 0.79 (3H, d, J 6.1 Hz); deltac 172.85, 171.82, 154.60, 147.28, 141.11, 132.50, 131.86, 113.32, 60.67, 50.39, 43.67, 40.56, 34.72, 28.83, 24.47, 22.34, 22.29, 21.27, 13.70, 13.37; (B) N-5-(2-methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-L-leucine ethyl ester Colourless oil (4% yield): i.r. (CDC13) 2210, 1730, 1670, 1610, 1510 cm-1 deltaH 8.73 (IH, s), 8.12 (IH, d, J 5.5 Hz), 7.46 (IH, d, J 8.1 Hz), 7.07 (IH, d, J 5.5 Hz), 4.45-4.32 (IH, m), 4.03-3.85 (4H, m), 2.41 (3H, s), 2.18-2.05 (2H, m), 1.72-1.28 (7H, m), 1.04 (3H, t, J 7.1 Hz), 0.71 (3H, d, J 6.3 Hz), 0.67 (3H, d, J 6.4 Hz); deltac 172.72, 171.87, 153.04, 140.73, 140.67, 139.64, 139.29, 104.61, 60.59, 50.38, 43.40, 40.47, 34.66, 28.56, 24.42, 22.30, 21.21, 13.65, 13.32. Examples 46-55 The compounds of Examples 46-55 may be prepared by the method of Example 11 employing the appropriate amino acid derivative in lieu of L-leucine ethyl ester hydrochloride as starting material and for certain compounds the appropriate substituted 4-bromopentanoyl chloride in lieu of 4-bromopentanoyl chloride. 46. N-5-(2-Methy limidazo[4,5-c]pyri din- l-yl)pentanoy 1-L-leucine i-propyl ester 47. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-0-methyl-L-tyrosine ethyl ester 48. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-D,L-allylglycine ethyl ester 49. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-L-norleucine allyl ester 50. N-5-(2-Methylimidazo[4,5-c]pyridin-l -yl)-2-methylpentanoyl-L-leucinyl ethyl ether 51. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethyIpentanoyl-L-leucine 2- benzoxyethylethyl ester 52. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)-3-hydroxypentanoyl-L-leucine 2- (2-ethoxyethoxy)ethyl ester 53. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-l-(3-methyl-l,2,4- oxadiazol-5-yl)-3-methylbutylamine 54. N-5-(2-Methylimidazo[4,5-c]pyridin-l-yl)pentanoyl-l-(6-ethylpyrazin-2-yl)- 3-methylbutylamine 55. N-5-(2-Memylimidazo[4,5-c]pyridin-l-yI)pentanoyI-L-leucinyl N'-ethyl- carbamate Example 56 (A) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester, (B) N-me yl-N-6-(2-me ylin--idazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine ethyl ester and (C) N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-5-yl)hexanoyl- L-leucine ethyl ester (a) N-Methyl-N-6-bromohexanoyl-L-leucine ethyl ester Sodium hydride (60% dispersion in oil; 2.0 g, 50 mmol) was added to a stirred solution of N-6-bromohexanoyl-L-leucine ethyl ester (15.0 g, 45 mmol) in anhydrous THF (150 ml) at 0°C. After the effervesence had ceased methyl iodide (8.4 ml) was added. The reaction mixture was allowed to warm up to room temperature and was stirred overnight. The solvent was removed under reduced pressure and the residue taken up in ethyl acetate, washed with brine, dried over anhydrous sodium sulphate, filtered and concentrated to give crude N-methyl-N- 6-bromohexanoyl-L-leucine ethyl ester (14.0 g, 89%) as a pale yellow oil which was used directly in the next step. deltaH 5.31 (IH, dd, J 10.0, 5.7 Hz), 4.20-4.04 (2H, m), 3.39 (2H, t, J 6.7 Hz), 2.89 (2.5H, s), 2.80 (0.5H, s), 2.41-2.28 (2H, m), 1.95-1.56 (6H, m), 1.54-1.36 (3H, m), 1.23 (3H, t, J 7.1 Hz), 0.92 (3H, d, J 6.2 Hz), 0.89 (3H, d, J 6.1 Hz). (b) (A) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hex-anoyl-L- leucine ethyl ester, (B) N-methyl-N-6-(2-methylimidazo-[4,5-c]pyridin-l- yl)hexanoyl-L-leucine ethyl ester and (C) N-methyl-N-6-(2-methylimidazo[4,5- c]pyridin-5-yl)hexanoyl-L-leucine ethyl ester The three regioisomers were prepared by the procedure of Example 11 Step (b), employing N-methyl-N-6-bromohexanoyl-L-leucine ethyl ester in lieu of N-3- bromopropanoyl-L-leucine ethyl ester, and were separated by chromatography. (A) N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester Yellow oil (5% yield for last step after chromatography (silica: 6% methanol in DCM)): i.r. (CDC13) 2210, 1725, 1630, 1400, 1195 cπrl deltaH 8.71 (IH, s), 8.38 (IH, d, J 5.5 Hz), 7.57 (IH, d, J 5.4 Hz), 5.33-5.27 (IH, m), 4.20-4.06 (4H, m), 2.86 (3H, s), 2.62 (3H, s), 2.49-2.26 (2H, m), 1.95- 1.80 (2H, m), 1.79-1.62 (4H, m), 1.49-1.32 (3H, m), 1.23 (3H, t, J 7.1 Hz), 0.92 (3H, d, J 6.9 Hz), 0.89 (3H, d, J 6.8 Hz); deltac 173.13, 171.98, 154.82, 141.70, 132.25, 113.84, 60.97, 54.18, 44.16, 37.28, 33.05, 31.17, 29.79, 26.51, 25.01, 24.28, 23.16, 21.34, 14.14; (B) N-methy l-N-6-(2-methylimidazo[4,5-c]pyridin- 1 -yl)hexanoy 1-L-leucine ethyl ester Yellow oil (6% yield): i.r. (CDC13) 2210, 1725, 1630, 1610, 1395, 1025 cm ~ l deltaH 8.94 (IH, s), 8.35 (IH, d, J 5.6 Hz), 7.23 (IH, d, J 4.9 Hz), 5.32-5.27 (IH, m), 4.18-4.07 (4H, m), 2.86 (3H, s), 2.61 (3H, s), 2.48-2.26 (2H, m), 1.87- 1.63 (6H, m), 1.59-1.31 (3H, m), 1.22 (3H, t, J 7.1 Hz), 0.94-0.87 (6H, m); deltac 172.91, 171.63, 152.99, 141.14, 141.08, 139.76, 139.45, 104.55, 60.66, 53.95, 43.60, 36.96, 32.74, 30.95, 29.25, 26.16, 24.69, 23.97, 22.88, 21.03, 13.83, 13.58; (C) N-methyl-N-6-(2-methy limidazo [4,5-c]pyridin-5-yi)hexanoy 1-L-leucine ethyl ester Colourless oil (17% yield): i.r. (CDCI3) 2200, 1730, 1630, 1435, 1320 cm-1 deltaH 8.31 (IH, s), 7.62 (IH, d, J 6.7 Hz), 7.43 (IH, d, J 6.7 Hz), 5.01-4.94 (IH, m), 4.13 (2H, t, J 7.0 Hz), 3.86-3.76 (2H, m), 2.58 (3H, s), 2.43 (3H, s), 2.07-1.99 (2H, m), 1.78-1.61 (2H, m), 1.50-1.30 (4H, m), 1.11-1.10 (3H, m), 0.92 (3H, t, J 7.1 Hz), 0.62 (3H, d, J 6.6 Hz), 0.58 (3H, d, J 6.5 Hz); deltac 172.48, 171.20, 153.72, 143.25, 130.37, 129.09, 111.30, 60.28, 59.06, 53.65, 36.59, 32.30, 30.86, 30.62, 25.08, 24.28, 23.25, 22.51, 20.69, 17.06. Example 57 (A) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-isoleucine allyl ester, (B) N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- isoleucine allyl ester and (C) N-methyl-N-6-(2-memyIimidazo[4,5-c]pyridin-5- yl)hexanoyl-L-isoleucine allyl ester The compounds of Example 57 were prepared by the methods of Example 1 Step (a) and Example 56 utilising L-isoleucine allyl ester hydrochloride in lieu of L- leucine ethyl ester hydrochloride as starting material, and were separated by chromatography. (A) N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-isoleucine allyl ester Yellow oil (4% yield for last step after chromatography (silica: 6% methanol in DCM)): i.r. (CDC13) 2210, 1730, 1630, 1400, 1180 cm-1 deltaH 8.72 (IH, s), 8.39 (IH, d, J 5.6 Hz), 7.57 (IH, d, J 5.7 Hz), 5.93-5.80 (IH, m), 5.33-5.17 (2H, m), 5.08-5.00 (IH, m), 4.61-4.56 (2H, m), 4.18 (2H, t, J 7.2 Hz), 2.93 (3H, s), 2.63 (3H, s), 2.33 (2H, t, J 7.1 Hz), 2.10-1.81 (3H, m), 1.79-1.63 (2H, m), 1.50-1.04 (4H, m), 0.98-0.76 (6H, m); deltac 172.54, 170.38, 154.26, 147.21, 141.26, 135.51, 131.94, 131.34, 117.87, 113.25, 64.66, 59.54, 43.64, 32.98, 32.64, 30.86, 29.30, 26.04, 24.63, 23.82, 15.27, 13.43, 10.17; (B) N-methyl-N-6-(2-methy limidazo [4,5-c]pyridin-l-yl)hexanoyl-L-isoleucine allyl ester Yellow oil (2% yield): i.r. (CDCI3) 2210, 1730, 1635, 1395, 1160 cm-1 deltaH 8.78 (IH, s), 8.18 (IH, d, J 5.5 Hz), 7.07 (IH, d, J 5.4 Hz), 5.79-5.62 (IH, m), 5.16-5.00 (2H, m), 4.93-4.82 (IH, m), 4.47-4.36 (2H, m), 4.00-3.86 (2H, m), 2.78 (3H, s), 2.44 (3H, s), 2.17 (2H, t, J 7.0 Hz), 1.95-1.75 (IH, m), 1.73-1.45 (4H, m), 1.34-1.10 (4H, m), 0.82-0.59 (6H, m); deltac 172.60, 170.41, 152.78, 141.02, 140.95, 139.58, 139.36, 131.34, 117.90, 104.37, 64.69, 59.60, 43.40, 33.02, 32.64, 29.09, 26.01, 24.66, 23.81, 15.30, 15.25, 10.20; (C) N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-5-yl)hexanoyl-L-isoleucine allyl ester Me O Yellow oil (8% yield): i.r. (CDCI3) 2200, 1730, 1630, 1315, 1125 cm-1 deltaH (250 MHz, CDC13); 8.27 (IH, s), 7.57 (2H, s), 5.89-5.76 (IH, m), 5.28- 5.14 (2H, m), 5.04-4.97 (IH, m), 4.59-4.52 (2H, m), 4.27 (2H, t, J 7.1 Hz), 3.44 (3H, s), 2.70 (3H, s), 2.28 (2H, t, J 7.0 Hz), 2.03 (3H, m), 1.74-1.60 (2H, m), 1.41-1.21 (4H, m), 0.97-0.72 (6H, m); deltac 174.45, 172.89, 156.01, 145.14, 131.59, 129.32, 128.43, 110.92, 118.35, 111.65, 65.10, 59.97, 59.30, 33.36, 32.84, 31.30, 25.63, 25.00, 23.69, 18.06, 15.55, 10.51. Example 58 (A) N-Methyl-N-6-(2-methy limidazo [4,5-c]pyridin-3 -y l)hexanoyl-L-leucinyl ethyl ether, (B) N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- leucinyl ethyl ether and (C) N-methy l-N-6-(2-methy limidazo [4,5-c]pyridin-5- yl)hexanoyl-L-leucinyl ethyl ether The compounds of Example 58 were prepared by the methods of Example 1 Step (a) and Example 56 utilising L-leucinyl ethyl ether in lieu of L-leucine ethyl ester hydrochloride as starting material, and were separated by chromatography. (A) N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucinyl ethyl ether Pale yellow oil (2% yield for last step after chromatography (silica: 5% methanol in DCM)): i.r. (CDC13) 2210, 1625, 1400, 1120cm-1 deltaH 8.60 (IH, s), 8.27 (IH, d, J 5.6 Hz), 7.44 (IH, d, J 5.9 Hz), 4.84-4.71 (0.5H, m), 4.06 (2H, t, J 7.3 Hz), 3.90-3.79 (0.5H, m), 3.42-3.17 (4H, m), 2.68 (1.5H, s), 2.62 (1.5H, s), 2.50 (3H, s), 2.23-2.12 (2H, m), 1.82-1.67 (2H, m), 1.64-1.51 (2H, m), 1.40-1.20 (4H, m), 1.15-0.92 (4H, m), 0.81-0.71 (6H, m); deltac 173.02, 172.46, 154.47, 147.43, 141.47, 132.70, 132.11, 113.47, 70.87, 70.55, 66.36, 65.82, 54.34, 49.55, 43.91, 37.90, 37.07, 33.15, 32.29, 29.54, 26.38, 26.29, 26.19, 24.31, 24.23, 24.16, 23.04, 22.97, 22.02, 21.81, 14.86, 14.80, 13.64; (B) N-methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l -yl)hexanoyl-L-leucinyl ethyl ether Pale yellow oil (1% yield): i.r. (CDCI3) 2210, 1620, 1395, 1120cm-1 deltaH 8.91 (IH, s), 8.31 (IH, d, J 5.6 Hz), 7.20 (IH, d, J 5.7 Hz), 4.91-4.78 (0.5H, m), 4.06 (2H, t, J 7.3 Hz), 3.98-3.87 (0.5H, m), 3.49-3.23 (4H, m), 2.76 (1.5H, s), 2.70 (1.5H, s), 2.57 (3H, s), 2.51-2.39 (0.5H, m), 2.32-2.18 (1.5H, m), 1.84-1.59 (4H, m), 1.48-1.28 (4H, m), 1.23-1.28 (4H, m), 0.90-0.80 (6H, m); deltac .173.23, 172.66, 153.06, 141.52, 141.36, 139.91, 139.67, 104.65, 71.01, 70.71, 66.54, 65.98, 54.52, 49.73, 43.79, 38.06, 37.22, 33.31, 32.43, 29.48, 26.47, 26.41, 24.84, 24.43, 24.28, 23.19, 23.11, 22.16, 21.96, 15.02, 14.95, 13.79; (C) N-methyl-N-6-(2-methylimidazo [4 ,5-c]pyridin-5-yl)hexanoyl-L-leucinyl ethyl ether Brown oil (9% yield): i.r. (CDC13) 2195, 1625, 1430, 1120 cm-1 deltaH 8.29 (IH, s), 7.63-7.57 (IH, m), 7.54-7.51 (IH, m), 4.88-4.72 (IH, m), 4.26 (2H, t, J 7.1 Hz), 3.45-3.20 (4H, m), 2.71 (3H, s), 2.65 (3H, s), 2.28-2.15 (2H, m), 1.97-1.82 (2H, m), 1.71-1.55 (2H, m), 1.45-1.17 (5H, m), 1.15-0.95 (3H, m), 0.85-0.75 (6H, m); deltac 173.45, 173.36, 172.63, 172.11, 155.27, 144.65, 144.59, 129.40, 129.32, 128.26, 111.10, 70.51, 70.17, 66.01, 65.51, 58.95, 53.99, 49.31, 37.54, 36.75, 32.73, 31.83, 30.96, 29.05, 25.91, 25.35, 25.25, 24.32, 23.93, 23.63, 23.40, 22.73, 22.64, 21.72, 21.50, 17.67. Examples 59-86 The compounds of Examples 59-86 may be prepared by the method of Example 58 employing the appropriate amino acid derivative in lieu of L-leucinyl ethyl ether as starting material and for certain compounds the appropriate substituted haloalkanoyl or haloalkylsulphonylchloride in lieu of 6-bromohexanoyl chloride. 59. N-Methy l-N-6-(2-methy limidazo [4,5-c]pyridin-l -yl)hexanoyl-L-leucinyl hexadecyl ether 60. N-Methyl-N-6-(2-methyIimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-phenyl- alaninyl ethyl ether 61. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucinyl 4- methoxybenzyl ether 62. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin- 1 -yl)hexanoyl-L-norleucinyl ethyl ether 63. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-0-benzyl-L- serinyl ethyl ether 64. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)-2-methylhexanoyl-L- leucinyl ethyl ether 65. N-Ethoxycarbonyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L- leucinyl ethyl ether 66. N-Methyl-N-6-(2-methylimidazo [4 ,5-c]py ridin- 1 -y l)-5-methoxyhexanoyl-L- leucinyl ethyl ether 67. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-l-(3-ethyl- l,2,4-oxadiazol-5-yl)-3-methylbutylamine 68. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l -yl)butanoyl-L-leucine ethyl ester 69. N-Allyl-N-4-(2-methylimidazo[4,5-c]pyridin-l -yl)butanoy 1-L-leucine i-propyl ester 70. N-Methy l-N-4-(2-methylimidazo[4,5-c]pyridin- 1 -yl)butanoyl-L-leuciny 1 ethyl ether 71. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- 1 -yl)-2-methylbutanoyl-L- leucinyl ethyl ether 72. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- 1 -yl)pentanoy 1-L-leucine ethyl ester 73. N-Methy l-N-5-(2-methylimidazo[4,5-c]pyridin- 1 -yl)pentanoyl-L-leucinyl ethyl ether 74. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin-l-yl)-2-methylpentanoyl-L- Ieucinyl ethyl ether 75. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin-l-yI)pentanoyl-L-leucinyl hexadecyl ether 76. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L- leucine ethyl ester 77. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin-l-yl)propyIsulphonyl-L- leucine i-propyl ester 78. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L- leucinyl ethyl ether 79. N-Methyl-N-3-(2-methyIimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L- leucinyl hexadecyl ester 80. N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin-l -yl)propylsulphonyl-l -(3- ethyl- 1 ,2,4-oxadiazol-5-yl)-3 -methy lbutylamine 81. N-Methyl-N-4-(2-methylimidazo [4,5-c]pyridin- 1 -yl)butylsulphonyl-L-leucine ethyl ester 82. N-Methyl-N-4-(2-memylimidazo[4,5-c]pyridin-l-yl)butylsulphonyl-L-leucinyl ethyl ether 83. N-Methyl-N-4-(2-methylimidazo [4,5-c]pyridin- 1 -yl)butylsulphonyl-L-leucinyl heptadecyl ether 84. N-Methyl-N-5-(2-methylimidazo [4 ,5-c]pyridin- 1 -yl)pentylsulphonyl-L-leucine ethyl ester 85. N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin-l-yI)pentylsulphonyl-L-leucine i-propyl ester 86. N-Methyl-N-5-(2-methylimidazo [4,5-c]pyridin- 1 -y l)pentyIsulphony l-L- leucinyl ethyl ether Example 87 (A) N-8-(2-Methylimidazo[4,5-c]pyridin-3-yl)octanoyl-L-leucine ethyl ester, (B) N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine ethyl ester and (C) N-8-(2-methylimidazo[4,5-c]pyridin-5-yl)octanoyl-L-leucine ethyl ester The compounds of Example 87 were prepared by the procedure of Example 11 utilising pentafluorophenyl-8-bromooctanoate in lieu of 4-bromobutanoyl chloride, and were separated by chromatography. (A) N-8-(2-methylimidazo[4,5-c]pyridin-3-yl)octanoyl-L-leucine ethyl ester Colourless oil (7% yield for last step after chromatography (silica: 6% methanol in DCM)): i.r. (CDC13) 2210, 1730, 1665, 1500, 1400cm-1 deltaH 8.58 (IH, s), 8.24, (IH, d, J 5.5 Hz), 7.43 (IH, d, 5.3 Hz), 6.68 (IH, d, J 8.2 Hz), 4.51-4.40 (IH, m), 4.06-3.95 (4H, m), 2.49 (3H, s), 2.06 (2H, t, J 7.4 Hz), 1.76-1.60 (2H, m), 1.58-1.34 (5H, m), 1.27-1.10 (6H, m), 1.11 (3H, t, J 7.4 Hz), 0.78 (3H, d, J 5.7 Hz), 0.76 (3H, d, J 5.7 Hz); deltac 172.98, 172.54, 154.50, 147.37, 141.33, 132.66, 132.03, 113.44, 60.75, 50.32, 43.94, 41.00, 35.73, 29.44, 28.51, 26.25, 25.00, 24.53, 22.46, 21.50, 13.79, 13.54; (B) N-8-(2-methy limidazo [4,5-c]pyri din- l-yl)octanoy 1-L-leucine ethyl ester Colourless oil (8% yield): i.r. (CDC13) 2210, 1730, 1670, 1500 cm-1 deltaH 8.78 (IH, s), 8.19 (IH, d, J 5.5 Hz), 7.08 (IH, d, J 5.5 Hz), 6.90 (IH, d, J 8.2 Hz), 4.51-4.38 (IH, m), 4.05-3.83 (4H, m), 2.45 (3H, s), 2.06 (2H, t, J 7.3 Hz), 1.67-1.30 (7H, m), 1.23-1.07 (6H, m), 1.08 (3H, t, J 7.1 Hz), 0.75 (3H, d, J 5.9 Hz), 0.73 (3H, d, J 6.0 Hz); deltac 172.89, 172.60, 152.96, 140.96, 139.70, 139.40, 104.54, 60.66, 50.30, 43.66, 40.88, 35.64, 29.18, 28.44, 26.19, 24.97, 24.47, 22.41, 21.43, 13.74, 13.48; (C) N-8-(2-methy limidazo [4,5-c]pyridin-5-yl)octanoy 1-L-leucine ethyl ester Colourless oil (7% yield): i.r. (CDC13) 2200, 1730, 1665, 1500, 1435 cm-1 deltaH 8.30 (IH, s), 7.50-7.48 (2H, m), 7.08 (IH, d, J 8.1 Hz), 4.52-4.41 (IH, m), 4.15 (2H, t, J 7.3 Hz), 4.04 (2H, q, J 7.1 Hz), 2.61 (3H, s), 2.06 (2H, t, J 7.3 Hz), 1.87-1.73 (2H, m), 1.65-1.40 (5H, m), 1.23-1.10 (9H, m), 0.80 (3H, d, J 6.4 Hz), 0.78 (3H, d, J 6.5 Hz); deltac 174.39, 173.23, 172.72, 150.04, 145.21, 129.09, 128.37, 111.50, 60.81, 59.44, 50.51, 40.88, 35.62, 31.78, 31.28, 28.40, 28.23, 25.63, 24.95, 24.62, 22.53, 21.50, 18.06, 13.86. Examples 88-96 The compounds of Examples 88-96 may be prepared by the method of Example 11 or Example 56 employing the appropriate amino acid derivative and the appropriate substituted haloalkanoyl chloride as starting materials. 88. N-8-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)-2-methyloctanoyl-L-leucine ethyl ester 89. N-8-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethyloctanoyl-L-phenyl- alanine ethyl ester 90. N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoy 1-L-leucine i- propyl ester 91. N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l -yl)octanoyl-L-leucinyl ethyl ether 92. N-Methyl-N-8-(2-methy limidazo [4,5-c]pyridin-l-yl)octanoyl-l-(3-ethy 1-1, 2,4- oxadiazol-5-yl)-3-methylbutylamine 93. N-7-(2-Methylimidazo [4,5-c]pyri din- l-yl)heptanoy 1-L-leucine ethyl ester 94. N-Methyl-N-7-(2-methylimidazo[4,5-c]ρyridm-l-yl)heptanoyl -L-leucinyl ethyl ether 95. N-Methyl-N-7-(2-methylimidazo[4,5-c]pyridin- 1 -y l)-2,2-dimethylheptanoyl- L-leucinyl ethyl ether 96. N-Methyl-N-7-(2-methylimidazo[4,5-c]ρyridin- 1 -yl)heptanoyl-L-leucinyl N'- hexadecylcarbamate Example 97 N-ll-(2-Methylbenzimidazol-l-yl)undecanoyl-L-leucine ethyl ester N-ll-(2-Methylbenzimidazol-l-yl)undecanoy 1-L-leucine ethyl ester was prepared by the procedure of Example 1 utilising pentafluorophenyl-11-bromoundecanoate in lieu of 6-bromohexanoyl chloride and 2-methylbenzimidazole in lieu of 2- methylimidazo[4,5-c]pyridine. Colourless oil (30% yield for last step after chromatography (silica: 4% methanol in DCM)): i.r. (CDCI3) 2200, 1730, 1665, 1500, 1400 cm-1 deltaH 7.63-7.58 (IH, m), 7.23-7.11 (3H, m), 6.42 (IH, d, J 7.7 Hz), 4.61-4.52 (IH, m), 4.11 (2H, q, J 6.7 Hz), 3.99 (2H, t, J 7.3 Hz), 2.52 (3H, s), 2.14 (2H, t, J 7.5 Hz), 1.79-1.40 (7H, m), 1.34-1.05 (15H, m), 0.88 (3H, d, J 5.3 Hz), 0.86 (3H, d, J 5.3 Hz); deltac 173.04, 172.76, 151.12, 142.33, 134.85, 121.61, 121.39, 118.64, 108.94, 60.88, 53.22, 50.41, 43.57, 41.29, 36.12, 29.44, 29.01, 28.93, 26.60, 25.31, 24.63, 24.38, 22.56, 21.69, 13.89, 13.61. Example 98 (A) N-ll-(2-Methylimidazo[4,5-c]pyridin-3-yl)undecanoyl-L-leucine ethyl ester and (B) N-ll-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucine ethyl ester The compounds of Example 98 were prepared by the procedure of Example 11 utilising pentafluorophenyl-11-bromoundecanoate in lieu of 4-bromobutanoyl chloride, and were separated by chromatography. (A) N-10-(2-Methylimidazo[4,5-c]pyridin-3-yl)undecanoyl-L-leucine ethyl ester Colourless oil (5% yield for last step after chromatography (silica: 5% methanol in DCM)): i.r. (CDCI3) 1730, 1665 cm-1 deltaH 8.66 (IH, br s), 8.32 (IH, br s), 7.50 (IH, d, J 5.3 Hz), 6.47 (IH, d, J 8.3 Hz), 4.60-4.50 (IH, m), 4.16-4.02 (4H, m), 2.57 (3H, s), 2.14 (2H, t, J 7.3 Hz), 1.82-1.69 (2H, m), 1.68-1.40 (5H, m), 1.36-1.10 (15H, m), 0.85 (3H, d, J 6.1 Hz), 0.84 (3H, d, J 6.2 Hz); deltac 173.12, 172.81, 154.62, 147.56, 141.50, 132.84, 132.15, 113.62, 60.93, 50.42, 44.13, 41.35, 36.21, 29.60, 28.95, 28.83, 26.51, 25.34, 24.68, 22.61, 21.71, 13.93, 13.73; (B) N-ll-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucine ethyl ester Colourless oil (5% yield): i.r. (CDC13) 1730, 1670 cm-1 deltaH (CDCL3)cm"l 8.93 (IH, br s), 8.34 (IH, br s), 7.20 (IH, d, J 5.3 Hz), 6.20 (IH, d, J 8.3 Hz), 4.64-4.53 (IH, m), 4.13 (2H, q, J 7.1 Hz), 4.06 (2H, t, J 7.4 Hz), 2.59 (3H, s), 2.16 (2H, t, J 7.3 Hz), 1.80-1.64 (2H, m), 1.66-1.41 (5H, m), 1.34-1.14 (15H, m), 0.90 (3H, d, J 6.0 Hz), 0.89 (3H, d, J 6.2 Hz); deltac 173.19, 172.78, 153.16, 141.51, 141.33, 140.01, 104.73, 61.09, 50.51, 44.03, 41.58, 36.34, 29.55, 29.12, 29.03, 28.98, 26.69, 25.41, 24.78, 22.68, 21.87, 14.01, 13.82. Examples 99-109 The compounds of Examples 99-109 may be prepared by the method of Example 11 or Example 56 employing the appropriate amino acid derivative and the appropriate substituted haloalkanoyl chloride or pentafluorophenyl haloalkanoate as starting materials. 99. N-9-(2-Methylimidazo[4,5-c]pyridin-l-yl)nonanoyl-L-leucine ethyl ester 100. N-Methyl-N-9-(2-methylimidazo[4,5-c]pyridin-l-yl)nonanoyl-L-leucine i- propyl ester 101. N-Methyl-N-9-(2-methylimidazo[4,5-c]pyridin-l -yl)nonanoyl-L-leucinyl ethyl ether 102. N-Methyl-N-9-(2-methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethylnonanoyl- L-Ieucinyl ethyl ether 103. N-Methyl-N-10-(2-methylimidazo[4,5-c]pyridin-l-yl)decanoyl-L-leucinyl ethyl ester 104. N-Methyl-N-10-(2-methylimidazo[4,5-c]pyridin-l-yl)decanoyl-L-leucine ethyl ester 105. N-Methyl-N-ll-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucine ethyl ester 106. N-Methyl-N-ll-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucinyl ethyl ether 107. N-Methyl-N-12-(2-methylimidazo[4,5-c]pyridin-l-yl)dodecanoyl-L-leucinyl ethyl ether 108. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-D-leucine euiyl ester 109. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin- l-yl)hexanoyl-L- phenylalanine ethyl ester Example 110 N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine 2M Potassium hydroxide (2.5 ml) was added to a solution of N-methyl-N-6-(2- methylimidazo[4,5-c]pyridin-l-yl)hexanoy 1-L-leucine ethyl ester (200 mg, 0.50 mmol) in ethanol (70 ml). The reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure and water was added to the residue. The pH of the resulting solution was adjusted to pH 6 by the addition of 2M HCl, the mixture was saturated with sodium chloride and extracted with DCM. The combined organic extracts were dried over anhydrous sodium sulphate, filtered and evaporated to give N-methyl-N-6-(2-methylimidazo[4,5- c]pyridin-l-yl)hexanoyl-L- leucine (70 mg, 38%) as a white foam. i.r. (CDCI3) 2590, 2215, 1720, 1640, 1400, 1315 cm-1 deltaH 9.51 (IH, s), 8.40 (IH, d, J 6.4 Hz), 7.89 (IH, d, J 6.4 Hz), 5.18 (IH, dd, J 10.4 Hz, 5.4 Hz), 4.48-4.31 (2H, m), 2.83 (3H, s), 2.75 (3H, s), 2.65-2.18 (2H, m), 1.93-1.30 (9H, m), 0.86 (3H, d, J 6.8 Hz), 0.82 (3H, d, J 6.5 Hz); deltac (CD3OD) 178.57, 177.27, 167.89, 155.81, 137.08, 130.86, 119.00, 58.23, 40.82, 40.83, 36.40, 34.64, 32.79, 29.67, 28.61, 27.94, 26.09, 24.11. Examples 111 and 112 The compounds of Examples 111 and 112 were prepared by the procedure of Example 110 starting from the compounds of Examples 56(C) and 57(A) respectively. 111. N-Methy l-N-6-(2-methylimidazo[4,5-c]pyridin-5-yl)hexanoy 1-L-leucine Yellow solid (29% yield): m.p. 80°C i.r. (CDCI3) 2210, 1720, 1625, 1400, 1125 cm-1 deltaH 9.20 (IH, s), 8.50 (IH, d, J 6.5 Hz), 8.00 (IH, d, J 6.7 Hz), 5.05 (IH, dd, J 10.2, 5.2 Hz), 4.80-4.57 (2H, m), 2.91 (3H, s), 2.75 (3H, s), 2.57-2.21 (2H, m), 2.10-1.91 (2H, m), 1.90-1.25 (7H, m), 0.90 (3H, d, J 6.5 Hz), 0.86 (3H, d, J 6.5 Hz); deltac (CD3OD) 178.29, 166.23, 150.20, 142.98, 140.24, 138.00, 114.99, 64.50, 58.79, 41.18, 36.50, 34.95, 34.77, 29.18, 28.74, 27.79, 26.34, 24.33. 112. N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-isoleucine White foam (54% yield after chromatography (silica: 6% methanol and 0.5% acetic acid in DCM): i.r. (CDCI3) 2230, 1715, 1630, 1400, 1135 cm-1 deltaH 8.85 (IH, s), 8.37 (IH, d, J 5.3 Hz), 7.67 (IH, d, J 5.5 Hz), 4.97 (IH, t, J 10.3 Hz), 4.20 (2H, t, J 7.2 Hz), 2.97 (3H, s), 2.66 (3H, s), 2.67-2.52 (IH, m), 2.34 (2H, t, J 6.9 Hz), 2.14-1.54 (6H, m), 1.52-1.10 (3H, m), 1.05-0.76 (6H, m); deltac 173.25, 173.15, 156.57, 148.22, 139.30, 132.66, 130.50, 114.13, 44.38, 33.36, 32.71, 29.57, 26.35, 24.41, 24.12, 15.89, 15.08. Examples 113-119 The compounds of Examples 113-119 may be prepared by the hydrolysis of the appropriate amino acid ester derivative according to the method of Example 110. 113. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine 114. N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-phenylalanine 115. N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine 116. N-4-(2-Methylimidazo [4,5-c]pyridin- 1 -yl)propylsulphonyl-L-methionine 117. N-8-(2-Methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine 118. N-MethyI-N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine 119. N-Methyl-N-ll-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucine Example 120 N-Me yl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucine ethyl ester (a) 4-(2-Methylimidazo[4,5-c]-pyridin-l-yl)benzoic acid Sodium hydroxide (0.39 g, 9.7 mmol) was added to water (5 ml) and the resultant solution added to a stirred solution of 4-(2-methylimidazo[4,5-c]- pyridin-l-yl)phenylnitrile [Cooper K. et al., J. Med. Chem. 35(17), 3115-3129 (1992)] (224 mg, 0.96 mmol). The mixture was heated under reflux for 1.5 h, cooled, concentrated under reduced pressure and concentrated to dryness to give a brown solid. The residue was taken up in water, neutralised to pH 7 and the resultant mixture passed down an acidic ion exchange column (eluting with 1- 30% aqueous ammonia) to give 4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoic acid (130 mg, 53%) as an amorphous solid. deltaH (400 MHz) 8.93 (IH, d, J 0.9 Hz), 8.31 (IH, d, J 5.5 Hz), 8.10 (2H, d, J 8.5 Hz), 7.51 (2H, d, J 8.5 Hz), 7.22 (IH, dd, J 5.0, 1.0 Hz), 2.51 (3H, s). (b) N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucine ethyl ester Oxalyl chloride (200 μl, 2.3 mmol) was added dropwise to a stirred suspension of 4-(2-methylimidazo[4,5-c]-pyridin-l-yl)benzoic acid (130 mg, 0.5 mmol) in dry DCM (10 ml) at 0°C under argon. DMF (3 drops) was added and the mixture allowed to warm up to ambient temperature slowly. After 1.5 h the reaction mixture was evaporated to dryness under reduced pressure. Dry DCM (10 ml) was added to the residue and L-leucine ethyl ester hydrochloride (142 mg, 0.72 mmol) and triethylamine (280 μl) added to the resulting solution. The mixture was stirred overnight at ambient temperature and concentrated under reduced pressure. The residue was taken up in ethyl acetate and washed with saturated aqueous sodium hydrogen carbonate and brine. The combined organics were dried over anhydrous magnesium sulphate, filtered and concentrated. Column chromatography (silica: 3% methanol in DCM) gave N- 4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucine ethyl ester (47 mg, 23%) as a pale yellow oil. deltaH (400 MHz) 9.06 (IH, s), 8.50 (IH, d, J 5.6 Hz), 8.04 (2H, d, J 8.6 Hz), 7.45 (2H, d, J 8.6 Hz), 7.07 (IH, dd, J 5.6, 1.0 Hz), 6.66 (IH, d, J 8.3 Hz), 4.87 (IH, m), 4.25 (2H, q, J 7.1 Hz), 2.55 (3H, s), 1.85-1.60 (3H, m), 1.32 (3H, t, J 7.1 Hz), 1.03 (3H, d, J 6.1 Hz), 1.00 (3H, d, J 6.3 Hz). (c) N-Methyl-N-4-(2-methy limidazo [4,5-c]pyridin- 1 -yl)benzoy 1-L-leucine ethyl ester A solution of N-4-(2-methy limidazo [4, 5-c]pyridin-l-yl)benzoy 1-L-leucine ethyl ester (71 mg, 0.18 mmol) in dry THF (3.5 ml) was added via cannula to a stirred suspension of sodium hydride (60% dispersion in oil: 10 mg, 0.25 mmol) in dry THF (1 ml) at room temperature under argon. The mixture was stirred for 0.5 h and dimethyl sulphate (24 μl, 0.25 mmol) added. The mixture was stirred overnight, aqueous ammonium chloride added, the mixture extracted with ethyl acetate and the organics washed with water and brine. The combined organics were dried over anhydrous magnesium sulphate, filtered and concentrated under reduced pressure. Column chromatography (silica: 3% methanol in DCM) gave N-methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l- yl)benzoyl-L-leucine ethyl ester (23 mg, 31%) as a pale yellow oil. deltaH (400 MHz) 9.06 (IH, s), 8.40 (IH, d, J 5.6 Hz), 8.04 (2H, d, J 7.8 Hz), 7.43 (2H, d, J 8.0 Hz), 7.11 (IH, m), 5.38 (0.6H, m), 4.37 (0.4H, m), 4.24 (2H, br m), 3.03 (1.2H, s), 2.99 (1.8H, s), 2.56 (3H, s), 1.90-1.47 (3H, m), 1.32 (3H, t, J 7.1 Hz), 1.04 (3.6H, d, J 6.3 Hz), 0.89 (1.2H, d, J 5.0 Hz), 0.71 (1.2H, d, J 5.5 Hz). Examples 121-129 The compounds of Examples 121-129 may be prepared by the method of Example 120 employing the appropriate amino acid derivative in lieu of L-leucine ethyl ester hydrochloride as starting material. 121. N-Methy l-N-4-(2-methy limidazo [4 ,5-c]pyridin- 1 -y l)benzoyl-L-leucinyl ethyl ether 122. N-Methyl-N-4-(2-memylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-phenylalanine ethyl ester 123. N-Memyl-N-4-(2-me ylimidazo[4,5-c3pyridin-l-yl)benzoyl-L-leucin n- butyl ester 124. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-isoleucine ethyl ester 125. N-Ethyl-N-4-(2-methylimidazo[4,5-c]pyridin-l -yl)benzoyl-L-leucine ethyl ester 126. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucine 2- pyridyl amide 127. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucinyl N'- ethylcarbamate 128. N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoy 1-L-leucinyl ethanoate 129. N-Methy l-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoy 1-1 -(3-ethyl- l,2,4-oxadiazol-5-yl)-3-methylbutylamine Example 130 N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester (a) Methyl 4-(2-(3-pyridyl)ethenyl)benzoate Solid potassium t-butoxide (3.42 g, 30.5 mmol) was added in one portion to a stirred suspension of (3-pyridyl)methyltriphenylphosphonium chloride hydrochloride (5.20 g, 12.2 mmol) in DMF (90 ml) at 50°C under argon. After 5 min a solution of methyl 4-formylbenzoate (2.0 g, 12.2 mmol) in DMF (10 ml) was added via cannula. The reaction mixture was stirred overnight at 50°C, and concentrated under reduced pressure. The residue was dissolved in ethyl acetate (250 ml) and washed with water (100 ml). The organics were extracted with 2M HCl (2x100 ml) and the combined acidic aqueous layers washed with ethyl acetate (100 ml) then basified to pH 10 by the addition of aqeous sodium hydroxide followed by potassium carbonate. The mixture was extracted with ethyl acetate (2x200 ml) and the combined organics dried over anhydrous magnesium sulphate, filtered and evaporated to give a 30:70 mixture of trans- and s-methyl 4-(2-(3- pyridyl)ethenyl)benzoate (2.2 g, 75%) as a brown gum which crystallised on standing. deltaH (400 MHz) 8.74 (0.3H, d, J 2.0 Hz), 8.51 (0.3H, dd, 4.8, 1.6 Hz), 8.45 (0.7H, d, J 2.2 Hz), 8.42 (0.7H, dd, 4.8, 1.6 Hz), 8.03 (0.6H, d, J 8.4 Hz), 7.90 (1.4H, d, J 8.4 Hz), 7.83 (0.3H, dt, J 8.0, 1.8 Hz), 7.57 (0.6H, d, J 8.5 Hz), 7.46 (0.7H, dt, J 7.9, 1.8 Hz), 7.29 (0.3H, dd, J 7.9, 4.8 Hz), 7.26 (1.4H, d, J 8.2 Hz), 7.17 (0.6H, s), 7.11 (0.7H, dd, J 7.9, 4.7 Hz), 6.75 (0.7H, d, J 12.2 Hz), 6.64 (0.7H, d, J 12.2 Hz), 3.92 (0.9H, s), 3.89 (2.1H, s). (b) Methyl 4-(2-(3-pyridyl)ethyl)benzoate Hydrogen gas was slowly bubbled through a vigorously stirred mixture of methyl 4-(2-(3-pyridyl)ethenyl)benzoate (952 mg, 3.98 mmol) and 10% palladium on carbon (95 mg) at room temperature for 4 h. The reaction mixture was filtered through Kieselguhr which was then washed with excess ethyl acetate. The combined organics were evaporated under reduced pressure to give methyl 4-(2- (3-pyridyl)ethyl)benzoate (900 mg, 94%) as an oil which crystallised on standing. deltaH (400 MHz) 8.43 (IH, dd, J 4.8, 1.6 Hz), 8.40 (IH, d, J 2.0 Hz), 7.93 (2H, d, J 8.4 Hz), 7.39 (IH, dt, J 7.7, 2.0 Hz), 7.18 (2H, d, J 8.4 Hz), 7.15 (IH, dd, J 7.8, 4.8 Hz), 3.89 (3H, s), 2.95 (4H, m). (c) N-4-(2-(3-Pyridyl)ethyl)benzoyl-L-leucine ethyl ester Methyl 4-(2-(3-pyridyl)ethyl)benzoate was dissolved in methanol (10 ml) and a solution of potassium hydroxide (2.1 g, 37.3 mmol) in water (2 ml) added. The mixture was stirred overnight and the pH lowered to ca. 7 by the cautious addition of concentrated hydrochloric acid. Methanol (20 ml) was added and the suspension filtered, the filtrate concentrated to give an oil to which 2M HCl was added to bring the pH to 8. A solid precipitate formed, the solvent was removed under reduced pressure and the residue azeotroped with toluene (1x100 ml, 1x50 ml) to give crude 4-(2-(3-pyridyl)ethyl)benzoic acid. Thionyl chloride (10 ml) and dry DMF (100 μl) were added to the crude 4-(2-(3-pyridyl)ethyl)benzoic acid and the mixture heated under gentle reflux for 1.5 h. The excess thionyl chloride was removed under reduced pressure and the residue azeotroped with toluene (x2) to give crude 4-(2-(3-pyridyl)ethyl)benzoyl chloride hydrochloride as a solid. DCM (20 ml) was added and the resultant suspension treated with L-leucine ethyl ester hydrochloride (733 mg, 3.73 mmol), triethylamine (5.2 ml, 37.3 mmol) and DMAP (30 mg). The mixture was stirred for 1 h at room temperature, diluted with DCM (50 ml) and the solution washed with water (2x20 ml) and saturated brine (20 ml). The combined organics were dried over anhydrous magnesium sulphate, filtered and evaporated to give a yellow oil. Column chromatography (silica: 4% methanol in DCM) gave N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester (378 mg, 28%) as a yellow solid. i.r. (Film) 3355, 2960, 1750, 1635, 1520, 1500, 1160 cm-1 deltaH (400 MHz) 8.45 (IH, br d, J 3.7 Hz), 8.42 (IH, br s), 7.71 (2H, d, J 8.3 Hz), 7.43 (IH, dt, J 7.8, 1.9 Hz), 7.21 (IH, dd, J 7.7, 4.9 Hz), 7.18 (2H, d, J 8.3 Hz), 6.49 (IH, d, J 8.3 Hz), 4.83 (IH, m), 4.22 (2H, q, J 7.1 Hz), 2.96 (4H, m), 1.80-1.60 (3H, m), 1.29 (3H, t, J 7.1 Hz), 0.99 (3H, d, J 6.1 Hz), 0.97 (3H, d, J 6.3 Hz). (d) N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester A solution of N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester (378 mg mg, 1.03 mmol) in dry THF (16 ml) was added via cannula to a stirred suspension of sodium hydride (60% dispersion in oil: 10 mg, 0.25 mmol) in dry THF (3 ml) at room temperature under argon. The mixture was stirred for 0.5 h and dimethyl sulphate (107 μl, 1.13 mmol) added. The mixture was stirred for 1.5 h, saturated aqueous ammonium chloride added (5 ml), the mixture extracted with ethyl acetate (3x20 ml) and the organics washed with brine (10 ml). The combined organics were dried over anhydrous magnesium sulphate, filtered and concentrated under reduced pressure. Column chromatography (silica: 30% hexane in ethyl acetate) gave N-methyl-N-4-(2-(3- pyridyl)ethyl)benzoyl-L-leucine ethyl ester (21 mg, 7%) as a pale yellow oil. i.r. (Film) 2960, 1740, 1640, 1395, 1330, 1190 cm-1 deltaH (400 MHz) 8.46-8.37 (2H, br m), 7.41 (IH, dt, J 7.7, 1.9 Hz), 7.35-7.08 (5H, br m), 5.34 (0.6H, m), 4.35 (0.4H, m), 4.21 (2H, br m), 3.00-2.82 (7H, m), 1.85-1.40 (3H, m), 1.29 (3H, t, J 7.1 Hz), 0.98 (3.6H, d, J 6.3 Hz), 0.85 (1.2H, d, J 5.0 Hz), 0.62 (1.2H, d, J 5.5 Hz). deltac (100.6 MHz) 173.37, 166.90, 149.36, 147.50, 147.44,, 144.81, 142.60, 136.74, 132.32, 128.82, 127.42, 123.60, 61.53, 51.33, 42.18, 37.24, 34.62, 25.12, 22.93, 22.28, 21.60, 14.27 Examples 131-139 The compounds of Examples 131-139 may be prepared by the method of Example 130 employing the appropriate amino acid derivative in lieu of L-leucine ethyl ester hydrochloride. 131. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoy 1-L-leucinyl ethyl ether 132. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine i-propyl ester 133. N-Ethyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester 134. N-Methy l-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-norleucinyl ethyl ether 135. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-l-tetrahydrofuryl-3-methyl- butylamine 136. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-vaIine ethyl ester 137. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-N'-methyl-L-tryptophan ethyl ester 138. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-0-benzyl-L-serine ethyl ester 139. N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-isoleucinyl ethyl ether Example 140 N-4-(3-Pyridylcyanomethyl)piperazinecarbonyl-L-leucine ethyl ester N (a) 4-(3-Pyridylcyanomethyl)piperazine A solution of nicotinaldehyde (5.1 ml, 54 mmol) in methanol (60 ml) was added to a stirred solution of piperazine (14.0 g, 160 mmol) and potassium cyanide (5.4 g, 83 mmol) in water (60 ml) and 1M phosphate buffer solution (pH 7.3: 60 ml). The reaction mixture was stirred for 48 h at ambient temperature and partitioned between water (80 ml) and ethyl acetate (2x100 ml). The organics were dried over anhydrous sodium sulphate, filtered and concentrated. Chromatography (silica gel: 2% methanol in DCM) gave 4-(3- pyridylcyanomethy piperazine (1.3 g, 12%) as a colourless oil. deltaH 8.71 (IH, d, J 2.3 Hz), 8.55 (IH, dd, J 4.8, 1.4 Hz), 7.79 (IH, dt, J 7.8, 2.1 Hz), 7.29 (IH, dd, J 7.7, 4.9 Hz), 4.81 (IH, s), 2.84 (4H, m), 2.48 (4H, m), 1.68 (IH, br s). deltac 150.03, 149.22, 135.27, 128.74, 123.20, 114.16, 60.44, 50.87, 45.52. (b) Dipyrid-2-ylcarbonate Triethylamine (10.5 ml, 75 mmol) was added slowly to a solution of triphosgene (3.0 g, 10 mmol) and 2-hydroxypyridine (5.7 g, 60 mmol) in dry DCM (500 ml) at 0°C under argon. The mixture was allowed to warm to room temperature and was stirred overnight. The solvent was removed under reduced pressure and the residue taken up in ethyl acetate (500 ml), washed with saturated aqueous sodium hydrogen carbonate (2x150 ml) and brine (200 ml), dried over anhydrous sodium sulphate filtered and concentrated to give an orange oil. Crystallisation from ethyl acetate/hexane gave dipyrid-2-ylcarbonate as an off-white crystalline solid (3.70 g, 57%). deltaπ 8.42 (2H, dd, J 4.8, 1.1 Hz), 7.83 (2H, ddd, J 7.8, 7.7, 1.8 Hz), 7.30-7.23 (4H, m). (c) N-4-(3-Pyridylcyanomethyl)piperazinecarbonyl-L-leucine ethyl ester Dipyrid-2-ylcarbonate (234 mg, 1.1 mmol) was added to a stirred solution of triethylamine (100 μl, 1.1 mmol) and 4-(3-pyridylcyanomethyl)piperazine (140 mg, 0.7 mmol) in dry DCM (6 ml) at room temperature under argon. The mixture was stirred overnight, DCM (50 ml) added and the solution washed with saturated aqueous sodium hydrogen carbonate and brine. The organics were dried over anhydrous sodium sulphate, filtered and concentrated to give crude 4-(3-pyridylcyanomethyI)piperazinepyrid-2-ylcarbonate as a colourless oil. Dry DCM (2 ml) was added and the resultant solution transfered via cannula to a stirred mixture of L-leucine ethyl ester hydrochloride (160 mg, 0.8 mmol) and triethylamine (200 μl, 2.2 mmol) in dry DCM (10 ml) at room temperature under argon. The mixture was stirred overnight, DCM (50 ml) added and the solution washed with 10% aqueous citric acid. The organics were concentrated under reduced pressure and the residue partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate. The organic phase was washed with brine, dried over anhydrous sodium sulphate, filtered and evaporated to give a yellow foam. Chromatography (silica: 3% methanol in DCM) gave N-4- (3-pyridylcyanomethyl)piperazinecarbonyl-L-Ieucine ethyl ester (62 mg, 23%) as a colourless oil. deltaπ 8.70 (IH, d, J 2.3 Hz), 8.54 (IH, dd, J 4.8, 1.4 Hz), 7.77 (IH, dt, J 7.8, 2.1 Hz), 7.30 (IH, dd, J 7.7, 4.9 Hz), 4.81 (IH, s), 4.60-4.45 (IH, m), 4.10 (2H, q, J 7.1 Hz), 3.60-3.30 (4H, m), 2.45-2.30 (4H, m), 1.67-1.38 (3H, m), 1.21 (3H, t, J 7.5 Hz), 0.87 (3H, d, J 6.1 Hz), 0.84 (3H, d, J 6.3 Hz). Examples 141-143 The compounds of Examples 141-143 may be prepared by the method of Example 140 employing the appropriate amino acid derivative in lieu of L-leucine ethyl ester hydrochloride. The tertiary carbamates may be prepared by alkylation of the corresponding secondary amides or carbamates by the method of Example 130 Step (d). 141. N-4-(3-Pyridylcyanomethyl)piperazinecarbonyl-L-leucine ethyl ester 142. N-Methyl-N-4-(3 -pyridy lcyanomethy I)piperazinecarbonyl-L-leucine ethyl ester 143. N-Methyl-N-4-(3-pyridylcyanomethyl)piperazinecarbony 1-L-leucinyl ethyl ether Examples 144-149 The compounds of Examples 144-149 may be prepared by the method of Example 140 Step (a) employing the appropriate N-alkyl-N-4-piperidine- carbonyl amino acid derivative in lieu of piperazine. 144. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-leucine ethyl ester 145. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-leucinyl ethyl ether 146. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-leucine propyl ester 147. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-isoleucine ethyl ester 148. N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-phenylalanine ethyl ester 149. N-Ethyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-leucinyl ethyl ether Example 150 Inhibition of [3HJ-PAF Receptor Binding The inhibition of [3H]-PAF binding to human platelet plasma membrane by compounds of general formula I was determined by isotopic labelling and filtration techniques. Platelet concentrates were obtained from a hospital blood bank. These platelet concentrates (500-2500 ml.) were centrifiiged at 800 rpm for 10 minutes in a SORVALL RC3B centrifuge to remove the red blood cells present. (The word SORVALL is a trade mark.) The supernatant was subsequently centrifuged at 3,000 rpm in a SORVALL RC3B centrifuge to pellet the platelets present. The platelet rich pellets were resuspended in a minimum volume of buffer (150 mM NaCl, 10 mM Tris, 2 mM EDTA, pH 7.5) and layered onto Ficoll-Paque gradients, 9 ml platelet concentrate to 2 ml Ficoll, and centrifiiged at 1,900 rpm for 15 minutes in a SORVALL RT6000 centrifuge. This step removes the residual red blood cells and other nonspecific material such as lymphocytes from the preparation. The platelets which form a band between the plasma and the Ficoll were removed, resuspended in the above buffer and centrifiiged at 3,000 rpm for 10 minutes in a SORVALL RT6000 centrifuge. The pelleted platelets were resuspended in buffer (10 mM Tris, 5 mM MgCl2, 2 mM EDTA, pH 7.0), snap freezed in liquid N2 and allowed to thaw slowly at room temperature in order to lyse the platelets. The latter step was repeated at least 3 times to ensure proper lysis. The lysed platelets were centrifiiged at 3,000 rpm for 10 minutes in a SORVALL RT6000 centrifuge and resuspended in buffer. The latter step was repeated twice in order to remove any cytoplasmic proteins which may hydrolyse the platelet activating factor (PAF) receptor. The prepared platelet membranes may be stored at -70°C. After thawing the prepared membranes were centrifiiged in a SORVALL RT6000 at 3,000 rpm for 10 minutes and resuspended in assay buffer. The assay was conducted by preparing a series of Tris-buffered solutions of the selected antagonist of predetermined concentrations. Each of these solutions contained [3H]-PAF (0.5 nM; l-0-[3H]octadecyl-2-acetyl--?/ι-glycero-3-phosphoryl choline with a specific activity of 132 Ci/mmol), unlabelled PAF (1000 nM), a known amount of the test antagonist, and a sufficient amount of Tris-buffer solution (10 mM Tris, 5 mM MgCl2, pH 7.0, 0.25% BSA) to make the final volume 1 ml. Incubation was initiated by the addition of 100 μg of the isolated membrane fraction to each of the above solutions at 0°C. Two control samples, one (Cl) which contained all the ingredients described above except the antagonist and the other (C2) contains Cl plus a 1000-fold excess of unlabelled PAF, were also prepared and incubated simultaneously with the test samples. After 1 hour incubation, each solution was filtered rapidly under vacuo through a WHATMAN GF/C glass fibre filter in order to separate unbound PAF from bound PAF. (The word WHATMAN is a trade mark.) The residue in each case was rapidly washed 4 times with 5 ml cold (4°C) Tris-buffer solution. Each washed residue was dried under vacuum on a sampling manifold and placed into vials containing 20 ml of OPTIPHASE MP scintillation fluid and the radioactivity counted in a liquid scintillation counter. (The word OPTIPHASE is a trade mark.) Defining the counts for total binding with antagonist from a test sample as "TBA"; the counts for total binding from the control sample Cl as "TB"; and the counts for nonspecific binding from the control sample C2 as "NSB", the percent inhibition of each test antagonist can be determined by the following equation: %Inhibition = [(TB-TBA)/SB]xl00 where the specific binding SB = TB-NSB Table 1 lists results from this assay for inhibition of [3HJ-PAF receptor binding for illustrative examples of the compounds of this invention. Table 1: Results for inhibition of [3HJ-PAF receptor binding Example 151 Inhibition of PAF-Induced Hypotension in the Rat The activity of the compounds of general formula I is also demonstrated in vivo by their ability to reverse the hypotension caused by an infusion of PAF in rats. Male Sprague-Dawley rats (300-350 g) were anaesthetised with a mixture of sodium pentobarbitone, 22.5 mg/kg and thiopental 62.5 mg/kg. Through a midline incision in the neck, the trachea was cannulated and the animals breathed spontaneously. A carotid artery was cannulated for the measurement of blood pressure and this signal was used to trigger a rate meter to measure heart rate. Both jugular veins were cannulated: one for the infusion of PAF and the other for the bolus administration of test compounds. PAF, 100 ng/kg/min was infused i.v. until a sustained fall in mean blood pressure of 50 mmHg was achieved. Test compounds were administered i.v. as a bolus and resulted in a dose dependent reversal of the PAF induced hypotension. The peak of this reversal was measured and the dose to cause a 50% reversal of the hypotensive PAF response (ED50) calculated by straight line interpolation and the results are presented in Table 2. Table 2: Results for inhibition of PAF-induced hypotension in the rat

Claims: CLAIMS 1. A compound of general formula I: wherein: W represents pyrid-3-yl, benzimidazol-1-yl, imidazo[4,5-c]pyridin-l-yl, imidazo[4,5-c]pyridin-3-yl and imidazo[4,5-c]pyridin-5-yl optionally substituted with one or more -Cl-C6 alkyl substituents; Z represents: a) a divalent alkanediyl, alkenediyl or alkynediyl group from 2 to 12 carbon atoms which may be a straight or branched-chain provided that, when Z represents a branched chain at least two carbon atoms separate W from the group Q, wherein the said group is either unsubstituted or substituted by one or more substituents selected from hydroxy, -OCi-C alkyl, -SC1-C6 alkyl and halo; or b) a -(CH2)qU(CH2) group, optionally substituted by one or more substituents selected from hydroxy, -OC1-C6 alkyl, halo and nitrile, wherein q is an integer from 0-3, r is an integer from 0-3 and U is -0-, -S- or a furandiyl, tetrahydrofurandiyl, thiophenediyl, tetrahydrothiophenediyl, thiazolediyl, tetrahydrothiazolediyl, piperazinediyl, piperidinediyl, cyclopentanediyl, cyclohexanediyl, cycloheptenediyl or benzenediyl group (provided that, when U is a 1,4-benzenediyl group q is not an integer of 1); or c) a group wherein m is an integer from 0-3, X is -0-, -S- or -CH2- and each of R4 and R5 is independently hydrogen or -C -C6 alkyl; Q represents a carbonyl, thiocarbonyl or sulphonyl group or a bond Rl represents hydrogen, -C1-C6 alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, -COCi- C6 alkyl, -CO2C1-C6 alkyl, -(CO2C1-C6 alkyl)phenyl, -(C1-C6 alkyl)C02Cι- C6 alkyl, -(C1-C6 alkyl)phenyl, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl or phenyl optionally substituted by one or more substituents selected from -C1- 5 alkyl, -OC1-C6 alkyl, halogen, -CF3 and -CN; R2 represents hydrogen, halogen, -Ci-Cβ alkyl optionally substituted by one or more halogen atoms, -C2-C6 alkenyl, -C2-C6 alkynyl, -(C -C6 alkyl)C02Cι-C6 alkyl, -(C1-C6 alkyl)SCι-C6 alkyl, -(C1-C6 alkyl)OCι-C6 alkyl, -(Ci-Cg alkyl)N(Cι-C6 alkyl)2, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl, -(C1-C6 alkyl)C3-C8 cycloalkyl, -(C1 -C6 alkyl)C4-C8 cycloalkenyl, -(C1-C6 alkyl)OC3-C8 cycloalkyl, -(C1-C6 alkyl)OC4-C8 cycloalkenyl, -(C1-C6 alkyl)SC3-C8 cycloalkyl, -(Ci-Cg alkyl)SC4-C8 cycloalkenyl, a side chain of a naturally occurring amino acid, a group -D or -(C1-Q5 alkyl)OD wherein D is a group - (CH 2 ) n — ^- 7 D wherein n is an integer from 0 to 3, and each of R6 and R7 is independently hydrogen, -C\ -Cβ alkyl, -C2-C6 alkenyl, -C2-C6 alkynyl, halogen, -CN, -CO2H, -CO2C1 -C6 alkyl, -CONH2, -CONHC1-C6 alkyl, -CON(Cι-C6 alkyl)2, -CHO, -CH 2 OH, -CF3, -OC1-C6 alkyl, -SC1-C6 alkyl, -SOC1-C6 alkyl, -SO2C1-C6 alkyl, -NH2 or -NHCOMe; or Rl together with R^ and the atoms to which they are attached form a 5 to 8 membered nitrogen-containing heterocyclic ring; R3 represents hydrogen or halogen; B represents: a) a -VR8 group wherein V is -C(=0)-, -C(=0)0-, -CH2O-, -CH2θC(=0)-, -C(=S)-, -CH20C(=0)NH-, -C(=S)0-, -CH2S-, -C(=0)NHSθ2- or -S02NHC(=0)-; and R8 is hydrogen, -Cχ-Ci8 alkyl, -C2-C18 alkenyl, -C2-C18 alkynyl, -(C1-C alkyl)OCι -C6 alkyl, -(Cχ-C6 alkyl)SCι -C6 alkyl, -(Ci -Cβ alkyl)0(Cι-C alkyl)OCι-C6 alkyl, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl or pyridyl, (any o which may optionally be substituted with one or more substituents selected fro halogen, hydroxyl, nitro, nitrile or carboxyl), -C1-C4 perfluoroalkyl, a group - as defined above or a -(C1-C6 alkyl)OD group wherein D is as defined above; b) a -CH2NR9R10 group or a -CONR9R10 group wherein each of R9 and RlO is independently hydrogen, -C1-C18 alkyl, -C2-C18 alkenyl, -C2-CI8 alkynyl, -C3-C8 cycloalkyl, -C4-C8 cycloalkenyl, pyridyl (any of which may optionally be substituted with one or more substituents selected from halogen, hydroxyl, nitro, nitrile or carboxyl) or a group -D as defined above or R9 and RlO together with the nitrogen atom to which they are attached form a 5 to 8 membered nitrogen- containing heterocyclic ring; c) a group Y where Y is a 5- or 6-membered heterocyclic ring containing one or more heteroatoms selected from nitrogen, oxygen and sulphur and the ring may be optionally substituted with one or more substituents selected from -C1-C6 alkyl, -OC1-C6 alkoxy, halogen, -CF3 and -CN; or d) a group -CH2-Y or C(=0)NHY; where Y is as defined above; or a pharmaceutically or veterinarily acceptable acid addition salt or hydrate thereof. 2. A compound as claimed in Claim 1 wherein W represents pyrid-3-yl, 2- methylbenzimidazol-1-yl, 2-methylimidazo[4,5-c]pyridin-l-yl, 2- methylimidazo[4,5-c]pyridin-3-yl and 2-methylimidazo[4,5-c]pyridin-5-yl; 3. A compound as claimed in Claim 2, wherein Z represents: a) an alkanediyl having from 3 to 11 carbon atoms group, an alkenediyl group or an alkynediyl group, or; b) a -(CH2)πU(CH2)r group, optionally substituted by nitrile, wherein; U represents -0-, -S- or a tetrahydrofurandiyl, furandiyl, a thiophenediyl, a piperidinediyl or a benzenediyl group; q represents an integer of 0, 1, or 2 (provided that, when U is a 1,4-benzenediyI group q is not an integer of 1); and r represents an integer of 0. 4. A compound as claimed in Claim 3, wherein Z represents a propylene, 2-hydroxyproρylene, 1-methylpropylene, 1,1-dimethylpropylene, butylene, 1-methylbutylene, 1,1-dimethylbutylene, 3 -hydroxy butylene, pentylene, 1 -methylpentylene, 1 , 1 -dimethylpentylene, 4-hydroxypenylene, 4-methoxypentylene, hexylene, 1 ,1 -dimethylhexylene, heptylene, l-methylheptylene, 1,1-dimethylheptylene, octylene, 1,1-dimethyloctylene, nonylene, decylene, undecylene a group. 5. A compound as claimed in any one of Claims 1 to 4, wherein Q represents a carbonyl or sulphonyl group. 6. A compound as claimed in any one of Claims 1 to 5, wherein Rl represents a hydrogen atom, a -Cl -Cβ alkyl group, a -C2-C6 alkenyl group, or a -(C1-C6 alkyl)C02Cl-C6 alkyl group. 7. A compound as claimed in any one of Claims 1 to 6, wherein R-- represents a -C1-C6 alkyl group, a -C2-C6 alkenyl group, a -(Ci-Cβ aIkyl)SCι-C6 alkyl group, the side chain of a naturally occurring amino acid, a group -D or a -(Ci- C alkyl)OD group; wherein n represents an integer of 0 or 1, R6 represents a hydrogen atom or a -OC1-C6 alkyl group and R represents a hydrogen atom. 8. A compound as claimed in any one of Claims 1 to 7, wherein R represents a hydrogen atom. 9. A compound as claimed in Claim 7, wherein R3 represents the side chain of the amino acid leucine. 10. A compound as claimed in any one of Claims 1 to 9, wherein B represents a -VR8 group, a -CONR^RlO group or a group Y. 11. A compound as claimed in Claim 10 wherein V represents a -C(=0)0- group, a -CH2θC(=0)- group, a -CH2O- group, a -CH2θC(=0)- group or a -CH2θC(=0)NH- group. 12. A compound as claimed in Claim 10 wherein Y represents a a pyrazinyl group or a oxadiazolyl group. 12. A compound as claimed in Claim 10, or Claim 11, wherein R represents a hydrogen atom, -C1-C18 alkyl group, a -C2-C18 alkenyl group, a -(C1-C6 alkyl)0(C -C6 alkyl)OCι-C6 alkyl group, a pyridyl group, a group D or a -(Ci- C alkyl)OD group. 13. A compound as claimed in Claim 10 wherein R9 is a pyridyl group and R O is a hydrogen atom. 14. N-6-(2-Methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine ethyl ester, N-6-(2-MethyIimidazo[4,5-c]pyridin- 1 -yl)hexanoyl-D-leucine ethyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin-l -yl)hexanoyl-L-phenylalanine ethyl ester, N-6-(2-Methylimidazo[4,5-c]py ridin- 1 -yl)hexanoy 1-L-leucine propyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)hexanoyl-L-norleucine ethyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-0-benzyl-L-serine methyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2-methylhexanoyl-L-leucine ethyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)-2,2-dimethylhexanoyl-L-leucine ethyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)-5-hydroxyhexanoyl-L-leucine ethyl ester, N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine hexadecyl ester, N-4-(2-Methylimidazo [4,5-c]pyridin-3 -yl)butanoyl-L-leucine ethyl ester, N-4-(2-Methyiimidazo[4,5-c]pyridin- 1 -yl)butanoyl-L-leucine ethyl ester, N-4-(2-Methylimidazo [4,5-c]pyridin-5-yl)butanoyl-L-leucine ethyl ester, N-4-(2-Methylimidazo [4,5-c]pyridin- 1 -yl)butanoyl-L-leucine methyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yI)butanoyI-0-methyl-L-tyrosine eu yl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-methionine ethyl ester, N-4-(2-Methylimidazo [4,5-c]pyridin- 1 -y l)butanoyl-L-norleucine n-butyl ester, N-4-(2-MethyIimidazo [4,5-c]pyridin- 1 -yl)-2,2-dimethylbutanoy 1-L-leucine ethyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yI)-3-hydroxybutanoyl-L-leucine ethyl ester, N-4-(2-Methylimidazo [4,5-c] pyridin- 1 -yl)butanoyl-L-vaIine ethyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine hexyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine decyl ester, N-3-(2-Methylbenzimidazol- 1 -yl)propylsulphony 1-L-leucine ethyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-alanine ethyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-isoIeucine ethyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -y l)propylsulphony 1-L-norleucine ethyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-methionine ethyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine i-propyl ester, N-4-(2-Methy limidazo [4,5-c]pyridin- 1 -y l)propy lsulphonyl-L-leucine pentyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphony 1-L-leucine octyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin- 1 -yl)propylsulphonyl-L-leucine dodecyl ester, N-4-(2-MethyIimidazo[4,5-c]pyridin-l-yl)propylsulphonyI-L-leucine pentadecyl ester, N-4-(2-Methylimidazo [4,5-c]pyridin- 1 -y l)propylsulphonyl-L-leucine hexadecyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-leucine octadecyl ester, N-4-(2-Methylimidazo[4,5-c]pyridin-3-yl)propylsulphonyl-L-leucinyl ethyl ether, N-4-(2-methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl ethyl ether, N-4-(2-methy limidazo [4,5 -cjpyridin- -yl)propylsulphonyl-L-leucinyl ethyl ether, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl methyl ether, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl octyl ether, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propy 1 sulphony 1-L-leucinyl hexadecyl ether, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl benzyl ether, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl propionate, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl octa- decanoate, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl N'-ethyl carbamate, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl N'-benzyl carbamate, N-4-(2-Methylimidazo[4,5-c]ρyridin- -yl)propylsuIphonyl-L-leucinyl N'-2- pyridylcarbamate, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl N-octa- decylcarbamate, N-4-(2-Methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-l -(3-ethyl-l ,2,4- oxadiazol-5-yl)-3-methylbutylamine, N-5-(2-Methylimidazo[4,5-c]pyridin-: -yl)pentanoyl-L-leucine ethyl ester, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)pentanoyl-L-leucine ethyl ester, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)pentanoyl-L-leucine i-propyl ester, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)pentanoyl-0-methyl-L-tyrosine ethyl ester, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)pentanoyl-D,L-allylglycine ethyl ester, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)pentanoyl-L-norleucine allyl ester, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)-2-methylpentanoyl-L-leucinyl ethyl ether, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)-2,2-dimethylpentanoyl-L-leucine 2- benzoxyethylethyl ester, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)-3 -hydroxypentanoy 1-L-leucine 2-(2- ethoxyethoxy)ethyl ester, N-5-(2-Methy limidazo [4, 5-c]pyridin- -y l)pentanoy 1- 1 -(3-methyl- 1 ,2,4-oxadiazol- 5-yl)-3-methylbutylamine, N-5-(2-Methylimidazo[4,5-c]pyridin- -yl)pentanoyl-l-(6-ethylpyrazin-2-yl)-3- methylbutylamine, N-5-(2-Methylimidazo[4,5-c]ρyridin-l-yl)pentanoyl-L-leucinyl N'-ethyl- carbamate, N-Methyi-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucine ethyl ester, N-Methyl-N-6-(2-methylimidazo [4 ,5-c]pyridin- 1 -yl)hexanoy 1-L-leucine ethyl ester, N-Methyl-N-6-(2-methylimidazo [4 ,5-c]pyridin-5-yl)hexanoyl-L-leucine ethyl ester, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-isoleucine allyl ester, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-isoleucine allyl ester, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-5-yl)hexanoyl-L-isoleucine allyl ester, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-leucinyl ethyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucinyi ethyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-5-yI)hexanoyl-L-leucinyl ethyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucinyl hexadecyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hex-moyl-L-phenyl-alaninyl ethyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucinyl 4- methoxybenzyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-norleucinyl ethyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-0-benzyl-L-serinyl ethyl ether, N-Methyl-N-6-(2-memylimidazo[4,5-c]pyridin-l-yl)-2-methylhexanoyl-L-leucinyl ethyl ether, N-Ethoxycarbonyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucinyl ethyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)-5-methoxyhexanoyl-L- leuciήyl ethyl ether, N-Methyl-N-6-(2-methy limidazo [4,5-c]pyridin- 1 -y l)hexanoyl- 1 -(3 -ethyl- 1 ,2,4- oxadiazol-5-yl)-3-methylbutylamine, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin -l-yl)butanoyl-L-leucine ethyl ester, N-Allyl-N-4-(2-methylimidazo[4,5-c]pyridin-l- yl)butanoyl-L-leucine i-propyl ester, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)butanoyl-L-leucinyl ethyl ether, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)-2-methylbutanoyl-L-leucinyl ethyl ether, N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)pentanoyl-L-leucine ethyl ester, N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)pentanoy 1-L-leucinyl ethyl ether, N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)-2-methylpentanoyl-L- leucinyl ethyl ether, N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)pentanoyl-L-leucinyl hexadecyl ether, N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucine ethyl ester, N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucine i- propyl ester, N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -yl)propylsulphonyl-L-leucinyl ethyl ether, N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -y 1 )propy lsulphonyl-L-leucinyl hexadecyl ester, N-Methyl-N-3-(2-methylimidazo[4,5-c]pyridin- -y l)propy lsulphonyl- 1 -(3-ethyl- l,2,4-oxadiazol-5-yl)-3-methylbutylamine, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)butylsulphonyl-L-leucine ethyl ester, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)butylsulphonyl-L-leucinyl ethyl ether, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- -yl)butylsulphonyl-L-leucinyl heptadecyl ether, N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)pentylsulphonyl-L-leucine ethyl ester, N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)pentylsulphonyl-L-leucine i- propyl ester, N-Methyl-N-5-(2-methylimidazo[4,5-c]pyridin- -yl)pentylsulphonyl-L-leucinyl ethyl ether, N-8-(2-Methylimidazo [4,5 -c]pyridin-3 -y l)octanoy 1-L-leucine ethyl ester, N-8-(2-MethyIimidazo[4,5-c]pyridin- 1 -yl)octanoyl-L-leucine ethyl ester, N-8-(2-Methylimidazo[4,5-c]pyridin-5-yl)octanoyl-L-leucine ethyl ester, N-8-(2-Methylimidazo[4,5-c]pyridin- l-yl)-2-methyloctanoyl-L-leucine ethyl ester, N-8-(2-Methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethyloctanoyl-L-phenylalanine ethyl ester, N-Methyl-N-8-(2-methylimidazo[4,5-c]ρyridin-l-yl)octanoyl-L-leucine i-propyl ester, N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucinyl ethyl ether, N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoyl-l-(3-ethyl-l,2,4- oxadiazol-5-yI)-3-methylbutylamine, N-7-(2-Methylimidazo[4,5-c]pyridin-l-yl)heptanoyl-L eucine ethyl ester, N-Methyl-N-7-(2-methylimidazo[4,5-c]pyridin-l-yl)heptanoyl-L-leucinyl ethyl ether, N-Methyl-N-7-(2-memylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethylheptanoyl-L- leucinyl ethyl ether, N-Methyl-N-7-(2-methylimidazo[4,5-c]pyridin-l-yl)heptanoyl-L-leucinyI N'- hexadecylcarbamate, N-ll-(2-Methylbenzimidazol-l-yl)undecanoy 1-L-leucine ethyl ester, N-l 1 -(2-Methylimidazo[4,5-c]pyridin-3-yl)undecanoyl-L-leucine ethyl ester, N- 11 -(2-Methylimidazo [4,5-c]pyridin- 1 -yl)undecanoyl-L-leucine ethyl ester, N-9-(2-Methylimidazo[4,5-c]pyridin-l -yl)nonanoyl-L-leucine ethyl ester, N-Methyl-N-9-(2-methyhmidazo[4,5-c]pyridin-l-yl)nonanoyl-L-leucine i-propyl ester, N-Methyl-N-9-(2-methylimidazo[4,5-c]pyridin-l-yl)nonanoyl-L-leucinyl ethyl ether, N-Methyl-N-9-(2-methylimidazo[4,5-c]pyridin-l-yl)-2,2-dimethylnonanoyl-L- leucinyl ethyl ether, N-Methyl-N-10-(2-methylimidazo[4,5-c]pyridin-l-yl)decanoyl-L-leucinyl ethyl ester, N-Methyl-N-10-(2-methylimidazo [4,5-c]pyridin- 1 -yl)decanoyl-L-leucine ethyl ester, N-Methy 1-N- 11 -(2-methylimidazo [4 ,5 -c]pyridin- 1 -yl)undecanoy 1-L-leucine ethyl ester, N-Methyl-N-ll-(2-me ylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucinyl ethyl ether, N-Methyl-N-12-(2-methylimidazo[4,5-c]pyridin-l -yl)dodecanoyl-L-leucinyl ethyl ether, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin- 1 -yl)hexanoyl-D-leucine ethyl ester, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-phenylalanine ethyl ester, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-5-yl)hexanoyl-L-leucine, N-Methyl-N-6-(2-methylimidazo[4,5-c]pyridin-3-yl)hexanoyl-L-isoleucine, N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-leucine, N-6-(2-Methylimidazo[4,5-c]pyridin-l-yl)hexanoyl-L-phenylalanine, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)butanoyl-L-leucine, N-4-(2-Methylimidazo[4,5-c]pyridin-l-yl)propylsulphonyl-L-methionine, N-8-(2-Methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine, N-Methyl-N-8-(2-methylimidazo[4,5-c]pyridin-l-yl)octanoyl-L-leucine, N-Methyl-N-1 l-(2-methylimidazo[4,5-c]pyridin-l-yl)undecanoyl-L-leucine, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- 1 -yl)benzoy 1-L-leucine ethyl ester, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- 1 -yl)benzoyl-L-leucinyl ethyl ether, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-phenylalanine ethyl ester, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucine n-butyl ester, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-isoleucine ethyl ester, N-Ethyl-N-4-(2-methylimidazo[4,5-c]pyridin-l -yl)benzoyl-L-leucine ethyl ester, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- 1 -yl)benzoyl-L-leucine 2-pyridyl amide, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-L-leucinyl N'-ethyl- carbamate, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin- 1 -yl)benzoyl-L-leucinyl ethanoate, N-Methyl-N-4-(2-methylimidazo[4,5-c]pyridin-l-yl)benzoyl-l-(3-ethyl-l,2,4- oxadiazol-5-yl)-3-methylbutylamine, N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester, N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucinyl ethyl ether, N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine i-propyl ester, N-Ethyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-leucine ethyl ester, N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-norleucinyl ethyl ether, N-Methyl-N-4-(2-(3 -pyridy l)ethy l)benzoyl- 1 -tetrahy drofuryl-3 -methylbuty I- amine, N-Methyl-N-4-(2-(3 -pyridy l)ethyl)benzoyl-L-valine ethyl ester, N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-N , -methyI-L-tryptophan ethyl ester, N-Methyl-N-4-(2-(3 -pyridy l)ethyl)benzoy 1-0-benzyl-L-serine ethyl ester, N-Methyl-N-4-(2-(3-pyridyl)ethyl)benzoyl-L-isoleucinyl ethyl ether, N-4-(3-Pyridylcyanome yl)piperazinecarbonyl-L-leucine ethyl ester, N-4-(3 -Pyridylcy anomethy l)piperazinecarbonyl-L-leucine ethyl ester, N-Methyl-N-4-(3 -pyridylcyanomethy l)piperazinecarbonyl-L-leucine ethyl ester, N-Methyl-N-4-(3-pyridylcyanomethyl)piperazinecarbonyI-L-leucinyl ethyl ether, N-Methy l-N-4-(3 -pyridy ley anomethy l)piperidinecarbonyl-L-leucine ethyl ester, N-Methyl-N-4-(3 -pyridylcy anomethy l)piperidinecarbonyl-L-leucinyl ethyl ether, N-Methyl-N-4-(3-pyridylcyanomethyI)piperidinecarbonyl-L-leucine propyl ester, N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-isoleucine ethyl ester, N-Methyl-N-4-(3-pyridylcyanomethyl)piperidinecarbonyl-L-phenylalanine ethyl ester, N-Ethyl-N-4-(3 -pyridylcyanomethyl)piperidinecarbonyi-L-leucinyl ethyl ether; or a salt of such a compound. 15. A compound as claimed in any one of Claims 1 to 14 for use in human or veterinary medicine. 16. A compound as claimed in Claim 15 for use in the treatment or prophylaxis of diseases and conditions mediated by PAF. 17. The use of a compound as claimed in any one of Claims 1 to 14 in the preparation of an agent for the treatment or prophylaxis of diseases or conditions mediated by platelet activating factor. 18. A pharmaceutical or veterinary composition comprising a compound as claimed in any one of Claims 1 to 14 and a pharmaceutically and/or veterinarily acceptable carrier. 19. A process for preparing a compound of general formula I as defined in Claim 1, the process comprising: (a) treating a nitrogen heterocycle represented by general formula II w-H π wherein W is as defined in general formula I, with a suitable base (e.g. sodium hydride, potassium hydride or sodium bis(trimethylsilyl)amide), followed by a compound of general formula -HI wherein Z, Q, Rl, R--- R3 and B are as defined in general formula I, and L is a leaving group such as chloro, bromo, iodo, methanesulphonyloxy, p- toluenesulphonyloxy or trifluoromethanesulphonyloxy; (b) treating an amine represented by general formula IV wherein Rl, R2, R3, and B are as defined in general formula I, with a suitable base in an aprotic solvent followed by a halo derivative of general formula V , Z S „ Hal W Q Y wherein W, Z and Q are as defined in general formula I and Hal is a halide such as fluoro, chloro, bromo or iodo; (c) treating an amine of general formula IV with a derivative of general formula VI ,Z OH w cr VI wherein W and Z are as defined in general formula I and Q represents a -C(=0)- group, in the presence of a coupling reagent; and (d) optionally after step (a), step (b) or step (c) converting, in one or a plurality of steps, a compound of general formula I into another compound of general formula I. 20. A compound of general formula III wherein Z, Q, Rl, R--, R3 and B are as defined in general formula I, and L is a leaving group such as chloro, bromo, iodo, methanesulphonyloxy, p- toluenesulphonyloxy or trifluoromethanesulphonyloxy. 21. A compound of general formula V ,z^ „Hal w Q V wherein W, Z and Q are as defined in general formula I and Hal is a halide such as fluoro, chloro, bromo or iodo. 22. A compound of general formula VI w cr y wherein W, Z and Q are as defined in general formula I. 23. A method for the treatment or prophylaxis of diseases or physiological conditions of humans or mamalian animals mediated by platelet activating factor, comprising administering to the patient an amount of a compound as claimed in any of claims 1 to 14 effective to antagonise the effects of platelet activating factor on target cells responsible for such diseases or physiological conditions.

Inventors: BOWLES STEPHEN ARTHUR, MILLER ANDREW, WHITTAKER MARK, BOWLES, STEPHEN, ARTHUR, MILLER, ANDREW, WHITTAKER, MARK
Applicants: BRITISH BIO TECHNOLOGY, BRITISH BIO-TECHNOLOGY LIMITED
Application year: 1993
Main classification: C07C229
IPC codes: A61K31, A61P1, A61P9, A61P11, A61P37, A61P43, C07D213, C07D235, C07D471