ORAL 1 alpha -HYDROXYPREVITAMIN D

Abstract: Method of increasing activated vitamin D blood level by administering orally a 1 alpha -hydroxyprevitamin D or a delayed and sustained release formulation of activated vitamin D or a combination thereof. Both the previtamin D form and the delayed and sustained release activated vitamin D formulation increase vitamin D blood level without significant risk of hypercalcemia associated with other oral dosing of vitamin D forms.

Description: ORAL lβ -HYDROXYPREVITAMIN D TECHNICAL FIELD This invention relates to delayed and sustained release oral medicaments and, more specifically, to delayed and sustained release activated vitamin D, oral medicament. BACKGROUND OF THE INVENTION Vitamin D is known to be important in the regulation of calcium metabolism in animals and man. See, Harrison's Principals of Internal Medicine: Part Eleven, "Disorders of Bone and Mineral Metabolism," Chapter 335, E. Braunwald et al., (eds.), McGraw-Hill, New York (1987) pp. 1860-1865. Vitamin D 3 is synthesized endogenously in the skin of animals and man from 7-dehydrocholesterol by an ultraviolet-mediated photochemical reaction which breaks the B ring of the 7-dehydrocholesterol between carbon—4 and carbon-9 to form previtamin D 3 . The triene previtamin D 3 is unstable and over time thermally converts to vitamin D 3 . At normal body temperature an equilibrium exists between previtamin D 3 and vitamin D 3 , as seen below. Previtamin D3 As vitamin D 3 is further metabolized in vivo this equilibrium shifts to the vitamin D 3 form. It is known that vitamin D 3 must be hydroxylated at the carbon-l and the carbon-25 position before it is activated, i.e., before it will produce a biological response. A similar metabolism appears to be required to activate the other forms of vitamin D, e.g., vitamin D 2 and vitamin D 4 . As is generally understood and used herein, the term "vitamin D" is intended to include vitamins D 3 , D 2 , and D 4 . The term "activated vitamin D," as used herein, is intended to refer to vitamin D which has been hydroxylated in at least the carbon-l position of the A ring, e.g., lα-hydroxyvitamin D 3 . Functionally, vitamin D is more appropriately considered a hormone than a vitamin. When activated, vitamin D interacts with a vitamin D receptor protein and this interaction ultimately results in some form of biological response. For example, l ,25- dihydroxyvitamin D 3 is known to be a potent stimulator of calcium absorption from the intestine, such absorption is mediated by the interaction of the lα,25- dihydroxyvitamin D 3 molecule and the vitamin D receptor protein located in the epithelial cells (enterocytes) which line the intestine. In recent years it has become evident that the vitamin D receptor protein is widely distributed in the bodies of animals and man. Thus, it is not surprising that in addition to influencing calcium homeostasis, activated vitamin D has been implicated in osteogenesis, modulation of immune response, modulation of the process of insulin secretion by the pancreatic B cell, muscle cell function and the differentiation and growth of epidermal and hemopoietic tissues. Such a wide range of biological actions suggests that the activated forms of vitamin D compounds should be valuable therapeutic agents for a wide range of maladies such as metabolic bone disease, osteoporosis, psoriasis, psoriatic arthritis, colon, prostrate and breast cancer, and HIV infection. Unfortunately, when these agents are administered orally, the potent stimulation of calcium absorption by activated vitamin D can readily cause a dangerous hypercalcemia before the desired therapeutic response is obtained. For this reason, the activated vitamin D compounds are generally considered to have a low therapeutic to toxic ratio or low therapeutic index. Additionally, the presently known oral formulations when administered produce an unphysiologically rapid increase in the blood level of both calcium and activated vitamin D hormone followed by an almost as rapid decrease in the blood level of activated vitamin D hormone. Such rapid peaks and valleys of either the blood calcium or the activated vitamin D hormone are undesirable and perhaps harmful. Recognizing the great potential of activated vitamin D as a therapeutic agent, alternative routes of administration which would allow higher sustained blood levels to be achieved and yet avoid the toxicity problems presented by the oral dosage form have been sought. To this end, an injectable form of lα,25- dihydroxyvita in D 3 has been developed by Abbott Laboratories and is marketed under the trade name Calcijex for the management of hypocalcemia in patients undergoing chronic renal dialysis. Topical and transdermal forms of the drug have also been suggested by Holick, U.S. Patent No. 4,230,701. These alternative routes of administration, however, lack the convenience and the reliability of an oral dosage form and, to that extent, have diminished the practicality and attractiveness of activated vitamin D compounds as therapeutic agents. What is needed, is an oral dosage form which produces a more physiological sustained increase in the blood level of activated vitamin D and has a more acceptable therapeutic index than is presently possible with heretofore known oral formulations of activated vitamin D. SUMMARY OF THE INVENTION The present invention responds specifically to the long-felt need heretofore unmet by the prior art and especially with a view to overcoming the inherent inadequacies of presently known oral vitamin D formulations. The present invention provides a delayed and sustained release, activated vitamin D, oral medicament. In one embodiment, the invention provides a pharmaceutical composition and method for increasing activated vitamin D blood level by administering orally a compound of formula (I) or (II) as defined hereinbelow. The compounds of formulas (I) and (II) include lα-hydroxyprevitamin D and lα,25- dihydroxyprevitamin D. In accordance with this embodiment of the invention, it has been unexpectedly found that orally administered lα,25-dihydroxyprevitamin D produces a sustained increase in the blood level of lα,25- dihydroxyvitamin D and has a higher therapeutic index than does orally administered lα,25-dihydroxyvitamin D. The increased activated vitamin D blood level is achieved with significantly less hypercalcemia than that resulting from oral dosing of the lα,25- dihydroxyvitamin D. This embodiment of present invention is carried out by manufacturing lα-hydroxyprevitamin D so that the lα- hydroxyprevitamin D form remains relatively stable at room temperature. The lα-hydroxyprevitamin D is then administered to an animal or human being in an oral dosage formulation. As the lα-hydroxyprevitamin D is released from the oral dosage formulation, it is absorbed from the intestine into the blood. In the lα- hydroxyprevitamin D form, the compound is inactive (i.e., does not bind to the vitamin D receptor protein) and does not stimulate intestinal calcium absorption. As the lα-hydroxyprevitamin D is warmed by the core temperature of the animal or human being, it is thermally converted to the corresponding activated vitamin D. The thermal conversion to the active form takes a sufficiently long period of time such that most of this conversion occurs in the time period after the lα-hydroxyprevitamin D has been absorbed into the blood stream of the animal or human being. Thus, the lα- hydroxyprevita in D oral dosage formulation produces a greater sustained blood level of the corresponding activated vitamin D with significantly less stimulation of intestinal calcium absorption than is obtained by administering orally the corresponding activated vitamin D itself. In another embodiment of the present invention, activated vitamin D is incorporated in sustained release formulation suitable for administration orally. Ideally, the formulation has an enteric coating which is resistant to disintegration in gastric juice. The enteric coating covers a matrix which binds the active form of the vitamin D for gradual release once the enteric coating has dissolved. The enteric coating is designed to dissolve at a pH above that which is found in the stomach and proximal part of the small intestine. In accordance with this embodiment of the invention, it has been found that when the enteric- coated, sustained release formulation of activated vitamin D is administered orally to an animal or human, it produces a sustained increase in the blood level of activated vitamin D and has a higher therapeutic index than does the heretofore known oral formulations of activated vitamin D. The invention is carried out by formulating the activated vitamin D preparation so that it is bound in a matrix which provides a sustained release when exposed to the contents of the intestine. The activated vitamin D containing matrix is then covered with an enteric coating that is resistant to disintegration in gastric juices. The enteric coated, sustained release formulation of activated vitamin D (hereafter referred to a "DSR activated D") is then administered orally to the animal or human. As the DSR activated D of the invention travels past the proximal portion of the small intestine, the enteric coating dissolves. The active vitamin D containing matrix is exposed to intestinal fluids and activated vitamin D is gradually released over a sustained period of time and absorbed into the blood stream. Since the major portion of activated vitamin D is absorbed at a point beyond the proximal portion of the small intestine, a reduced stimulation of calcium uptake from the intestine occurs. This reduces the risk of hypercalcemia and hypercalciuria thus increasing the therapeutic window. The gradual release also allows a greater sustained level of activated vitamin D compound in the serum to be obtained. In a third embodiment of the present invention the first and second embodiments are combined to provide a delayed and sustained release oral medicament of activated previtamin D (hereafter referred to as "DSR activated pre D") or of a combination of activated previtamin D and activated vitamin D (hereafter referred to as "DSR activated pre D and D") . This embodiment of the invention comprises one or more of the compounds of formulas (I) , (II) , (III) , and/or (IV) contained in an enteric coated, sustained release formulation suitable for oral administration. The foregoing and other advantages of the present invention are realized in one aspect thereof in a method for increasing the blood level of activated vitamin D in an animal or human being by administering orally an effective amount of lα-hydroxyprevitamin D, or an effective amount of activated vitamin D contained in the DSR activated D formulation of the invention or a combination thereof. A preferred embodiment of lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 3 and a preferred embodiment of activated vitamin D is lα,25- dihydroxyvitamin D 3 . In another aspect, the invention is a method of increasing blood level of activated vitamin D for a sustained period of time, typically greater than four hours. In yet another aspect, the invention is a method for treating osteoporosis by administering orally an effective amount of lα-hydroxyprevitamin D, or an effective amount of activated vitamin D contained in the DSR activated D formulation or a combination thereof. In a further aspect, the invention is a method of treating psoriasis by orally administering an effective amount of lα-hydroxyprevitamin D, or an effective amount of active vitamin D contained in the DSR activated D formulation or a combination thereof. The compounds of formulas (I) , (II) , (III) and/or (IV) are provided in pharmaceutical compositions in combination with a pharmaceutically acceptable excipient. These compositions constitute another aspect of the invention. Preferred compositions include compounds of formula (II) which include lα,25- dihydroxyprevitamin D 3 , lα,25-dihydroxyprevitamin D 2 , and lα,25-dihydroxyprevitamin D 4 and of formula (IV) which include lα,25-dihydroxyvitamin D 3 , lα,25-dihydroxyvitamin D 2 , and lα,25-dihydroxyvitamin D 4 . Other advantages and a fuller appreciation of the specific adaptations, compositional variations and chemical and physical attributes of this invention will be gained upon examination of the detailed description and appended claims. DETAILED DESCRIPTION The preferred embodiments of the present invention relate broadly to therapeutic methods for ameliorating certain medical conditions by improving blood levels of activated vitamin D, and specifically, to improving such levels for a sustained period of time with significantly less resultant hypercalcemia and hypercalciuria by administering orally the formulations described below. First Embodiment In accordance with the first embodiment of the present invention, it has been found that when substantially pure lα-hydroxyprevitamin D is administered orally, it produces a greater sustained increase in the blood level of activated vitamin D and significantly less hypercalcemia and hypercalciuria than the same amount of activated vitamin D administered orally in previously known formulations. As used herein, the term "substantially pure" means at least 85% pure lα-hydroxyprevitamin D. The term "sustained" as used herein means a blood level which remains relatively constant (i.e., + 10 pg/ml or + 10% of the mean value) for a period greater than a defined period. The lα-hydroxyprevitamin D of this embodiment of the present invention has the general formula (I) : (I) wherein R, is a side chain having at least 7 carbon atoms, and can be branched or unbranched, saturated or unsaturated, hetero-substituted or nonhetero- substituted, cyclic or noncyclic and wherein the thermal iso er (or vitamin form) of the lα-hydroxyprevitamin D of the general formula increases the serum calcium of the vitamin D deficient rat as determined by standard techniques used by biochemists in the vitamin D area. Among the preferred lα-hydroxyprevitamin D of this embodiment of the present invention are those having the formula (II) : (ID wherein B and C are either hydrogen or a carbon to carbon bond forming a double bond between 022 and 023; R,, R 3 , R 4 and R 5 are each independently hydrogen, hydroxy, lower alkyl, 0-lower alkyl, 0-lower acyl, 0-aromatic acyl or flouro; and R 2 is hydrogen or lower alkyl. Most preferred among the compounds of formula (II), i.e., most preferred lα- hydroxyprevitamin D compounds, are: lα,25-dihydroxy-precholecalciferol [lα,25- (OH) 2 preD 3 ]; l ,24,25-trihydroxy-precholecalciferol [lα,24,25- (OH) 3 preD 3 ]; lα-hydroxy-precholecalciferol[lα-(OH)preD 3 ] ; lα,24-dihydroxy-precholecalciferol[lα,24- (OH) 2 preD 3 ]; lα,24-dihydroxy-25-fluoro-precholecalciferol[lα,24- (OH) 2 25FpreD 3 ] ; lα , 25-dihydroxy-preergocalcif erol [ lα , 25- (OH) 2 preD 2 ] ; lα, 24 , 25-trihydroxy-preergocalcif erol [ lα, 24 , 25- (OH) 3 preD 2 ]; lα-hydroxy-preergocalcif erol [ lα- (OH) preD 2 ] ; lα,24-dihydroxy-preergocalciferol[lα,24-(OH) 2 preD 2 ] ; lα,24-dihydroxy-25-f luoro-preergocalciferol[lα,24- (OH) 2 25FpreD 2 ]; lα,25-dihydroxy-previtamin D 4 [lα,25-(OH) 2 preD 4 ] ; lα , 24 , 25-trihydroxy-previtamin D 4 [ lα , 24 , 25- (OH) 3 preD 4 ]; lα-hydroxy-previtamin D 4 [lα-(OH)preD 4 ] ; lα,24-dihydroxy-previtamin D 4 [lα,24-(OH) 2 preD 4 ] ; and lα,24-dihydroxy-25-fluoro-previtamin D 4 lα,24- (OH) 2 25FpreD 4 ] . In the formulae shown in this specification and in the claims, a wavy line to substituent X indicates that the substituent can be stereoisomeric alternate forms. Wherever in this specification and in the claims the word "lower" is used as a modifier of alkyl or acyl, it is intended to identify a hydrocarbon chain having from about 1 to 4 carbon atoms which has either a straight chain or branched chain configuration. Specific examples of such hydrocarbon chains are: methyl, ethyl, propyl, butyl, isobutyl or t-butyl, and formyl, acetyl, propionyl,or butyryl. The term "aromatic acyl" as used herein and in the claims is meant to identify a benzoyl group or a substituted benzoyl group such as nitrobenzoyl or dinitrobenzoyl. In a preferred embodiment, the compounds of formulas (I) or (II) are provided in a crystalline form. lα-Hydroxyprevitamin D in the crystalline form remains quite stable at room temperature with minimal conversion to the lα-hydroxyvitamin D form. The compounds of formulas (I) or (II), i.e., lα-hydroxyprevitamin D, can be readily manufactured in crystalline form according to the procedure described in Vandewalle, U.S. Patent 4,539,153. The pharmacologically active compounds of this embodiment can be processed in accordance with conventional methods of pharmacy to produce medicinal agents for administration to patients, e.g., mammals, including human beings. For example, dosage forms of the compounds of formulas (I) or (II) with conventional excipients, include admixtures suitable for oral administration. Dosage forms of the lα- hydroxyprevitamin D can be combined with any nontoxic pharmaceutically acceptable carrier, such as cornstarch, lactose, or sucrose, which does not deleteriously react with the active compounds. The formulation can be produced in tablet, capsule, powders, troches and lozenges. Whatever method of formulation is used, care should be taken to avoid extended exposure to solvents and heat as under such conditions there will be a tendency for a portion lα-hydroxyprevitamin D to convert to the lα-hydroxyvitamin D form. Because heat and dissolution are preferably avoided, the preferred method of tablet formulation is the method known as dry granulation. The lα-hydroxyprevitamin D is administered to the animal or human in oral dosage formulation. As the lα- hydroxyprevitamin D is released from the oral dosage formulation, it is absorbed from the intestine into the blood. lα-Hydroxyprevitamin D does not interact with the vitamin D receptor protein of the enterocytes and, therefore, does not stimulate intestinal calcium absorption. It is also known that the binding of activated vitamin D with the vitamin D receptor protein of the enterocyte induces the release of enzymes which degrade a significant portion of the unbound activated vitamin D present in the intestine. Such degradation decreases the amount of activated vitamin D available for absorption into the blood stream. Since lα- hydroxyprevitamin D does not bind with the vitamin D receptor protein there is no enzyme induction. Thus, less degradation occurs in the intestine and a greater amount is available for absorption into the blood stream than is the case with the corresponding activated vitamin D. As the lα-hydroxyprevitamin D is warmed by the core temperature of the animal or human being, it is thermally converted to the corresponding activated vitamin D. The reaction time for thermal conversion to the active form is sufficiently long so that most of the conversion occurs over time after the lα- hydroxyprevitamin D has been absorbed into the blood stream. Thus, the lα-hydroxyprevitamin D oral dosage formulation produces a greater sustained blood level of the corresponding activated vitamin D with significantly less stimulation of intestinal calcium absorption than is possible with a comparable oral dosage amount of the activated vitamin D itself. Second Embodiment In the second embodiment of the present invention, one or more of activated vitamin D compounds are included in an enteric coated, sustained release formulation. Surprisingly, it has been found that the DSR activated D formulation of the invention significantly increases the therapeutic window of the activated vitamin D compound. That is, the risk of hypercalcemia and hypercalciuria is significantly decreased and the therapeutic effectiveness is significantly increased for the activated vitamin D when orally administered in the DSR activated D formulation as compared to the same amount of activated vitamin D orally administered in heretofore known oral formulations of those compounds. Furthermore, the DSR activated D formulation permits a higher sustained blood level of the activated vitamin D to be obtained than was possible with previously known oral formulations of the activated vitamin D compound. The lα-hydroxyvitamin D of this embodiment of the present invention has the general formula (III) : (III) wherein R, is a side chain having at least 7 carbon atoms, and can be branched or unbranched, saturated or unsaturated, hetero-substituted or nonhetero- substituted, cyclic or noncyclic or any vitamin D compound or homologue which binds with the vitamin D receptor protein. Among the preferred lα-hydroxyvitamin D compounds of this embodiment of the present invention are those having the formula (IV) : (IV) wherein B and C are either hydrogen or a carbon to carbon bond forming a double bond between 022 and 023; Ri, R 3 , R,, and R 5 are each independently hydrogen, hydroxy, lower alkyl, O-lower alkyl, O-lower acyl, O-aromatic acyl or flouro; and R 2 is hydrogen or lower alkyl. Most preferred among the compounds of formula (II), i.e., most preferred lα-hydroxyvitamin D compounds, are: lα,25-dihydroxy-cholecalciferol [lα,25-(0H) 2 D 3 ] ; lα,24,25-trihydroxy-cholecalciferol [lα,24,25- (0H) 3 D 3 ]; lα-hydroxy-cholecalcif erol [ lα- (OH) D 3 ] ; lα-hydroxy-25-fluoro-cholecalciferol [ lα- (OH) 25FD 3 ] lα , 24-dihydroxy-cholecalciferol [ lα , 24- (0H) 2 D 3 ] ; lα,24-dihydroxy-25-fluoro-cholecalciferol[lα,24- (OH) 2 25FD 3 ]; lα , 25-dihydroxy-ergocalcif erol [ lα, 25- (OH) 2 D 2 ] ; lα,24,25-trihydroxy-ergocalciferol[lα,24,25- (OH) 3 D 2 ]; lα-hydroxy-ergocalcif erol [ lα- (OH) D 2 ] ; lα-hydroxy-25-f luoro-ergocalcif erol f lα- (OH) 25FD 2 ] lα , 24-dihydroxy-ergocalcif erol [ lα , 24- (OH) 2 D 2 ] ; lα,24-dihydroxy-25-fluoro-ergocalciferol[lα,24- (OH) 2 25FD 2 ]; lα,25-dihydroxy-vitamin D 4 [lα,25-(OH) 2 D 4 ] ; lα , 24 , 25-trihydroxy-vitamin D 4 [ lα , 24 , 25- (OH) 3 D 4 ] ; lα-hydroxy-vitamin D 4 [lα-(OH)D 4 ] ; lα-hydroxy-25-fluorovitamin D 4 [ lα- (OH) 25FD 4 ] ; lα , 24-dihydroxy-vitamin D 4 [ lα , 24- (OH) 2 D 4 ] ; and lα , 24-dihydroxy-25-fluoro-vitamin D 4 lα , 24- (OH) 2 25FD 4 ] . In the formulae shown in this specification and in the claims, a wavy line to substituent X indicates that the substituent can be stereoisomeric alternate forms. Wherever in this specification and in the claims the word "lower" is used as a modifier of alkyl or acyl, it is intended to identify a hydrocarbon chain having from about 1 to 4 carbon atoms which has either a straight chain or branched chain configuration. Specific examples of such hydrocarbon chains are: methyl, ethyl, propyl, butyl, isobutyl or t-butyl, and formyl, acetyl, propionyl,or butyryl. The term "aromatic acyl" as used herein and in the claims is meant to identify a benzoyl group or a substituted benzoyl group such as nitrobenzoyl or dinitrobenzoyl. The pharmacologically active compounds of this embodiment can be processed in accordance with conventional methods of pharmacy to produce delayed and sustained release medicinal agents (more specifically described below) for administration to patients, e.g., mammals, including human beings. For example, dosage forms of the compounds of formulas (III) and (IV) with conventional excipients, include admixtures suitable for oral administration. Dosage forms of the lα- hydroxyvitamin D can be combined with any nontoxic pharmaceutically acceptable carrier, such as cornstarch, lactose, or sucrose, which does not deleteriously react with the active compounds. The DSR formulation can be produced in tablet or capsule form. The preferred formulation of this embodiment is a matrix which binds the lα,25-dihydroxyvitamin D 3 along with an acceptable pharmaceutical excipient and which permits a slow, relatively steady release of the 1,25- dihydroxyvita in D 3 over a period of four to eight hours. The formulation further has an enteric coating that dissolves at a pH of about 6.0 to 7.0. The means for providing sustained (i.e., controlled) release of the active ingredient may be selected from any of the known sustained-release delivery systems for controlling the release of an active ingredient over a course of about four or more hours including the wax matrix system, and the Eudragit RS/RL system (of Rohm Pharma, GmbH, Weiterstadt, Germany) . The wax matrix system disperses the active ingredient(s) in a wax binder which slowly dissolves in body fluids to gradually release the active ingredient(s) . The preferred controlled-release oral drug delivery system is the Eudragit RL/RS system in which the active ingredient, activated D, is formed into granules having a dimension of 25/30 mesh. The granules are then uniformly coated with a thin polymeric lacquer which is water insoluble but slowly water permeable. The coated granules can be mixed with optional additives such as antioxidants, stabilizers, binder, lubricant, processing aids and the like. The mixture may be compacted into a tablet which, prior to use, is hard and dry or it may be poured into a capsule. After the tablet or capsule is swallowed and comes into contact with the aqeuous intestinal fluids, the thin lacquer begins to swell and slowly allows permeation of intestinal fluids. As the intestinal fluid slowly permeates the lacquer coating, the active ingredients are slowly released. By the time the tablet has passed through the intestinal tract, about four to eight hours, the active ingredients will have been slowly but completely released. Accordingly, the ingested tablet will release a stream of the activated D as well as any other active ingredient. The Eudragit system is comprised of high permeability lacquers (RL) and low permeability lacquers (RS) . The permeability of the coating and thus the time course of drug release can be titrated by varying the proportion of RS to RL coating material. For further details of the Eudragit RL/RS system, reference is made to technical publications available from Rohm Tech, Inc. 195 Canal Street, Maiden, Massachusetts, 02146. See also, K. Lehmann, D. Dreher "Coating of tablets and small particles with acrylic resins by fluid bed technology", Int . J. Pharm . Tech . & Prod . Mfr. 2(r), 31-43 (1981). Once the coated granuales are either formed into a tablet or put into a capsule, the tablet or capsule is coated with an enteric-coating material which dissolves at a pH of 6.0 to 7.0. One such pH dependent enteric- coating material is Eudragit L/S which dissolves in intestinal fluid but not in the gastric juices. Other enteric-coating materials may be used such as cellulose acetate phthalate (CAP) which is resistant to dissolution by gastric juices but readily disintegrates due to the hydrolytic effect of the intestinal esterases. The particular choice of enteric-coating material and sustained or controlled release coating material is not of significance as long as a sustained or controlled release over a period of 4 to 8 hours is obtained and release is delayed until the DSR formulation reaches the intestine. Although not essential to the invention, it is preferred that release is delayed until the DSR formulation has reached beyond the proximal part of the small intestine. The invention may also be practiced by omitting the enteric coating and using only a sustained release activated vitamin D oral formulation ("SR activated D") . While less desirable than the DSR activated D formulation, the SR activated D formulation is found to provide a wider therapeutic index than any heretofore known oral formulation of activated D. It is to be understood that the SR activated D formulation is considered to fall within the scope of the invention described and claimed herein. Third Embodiment The third embodiment of the invention combines the teachings of the first and second embodiments. That is, an effective amount of one or more of the lα- previtamin D compounds of formulas (I) or (II) of the first embodiment can be contained in a delayed and sustained release formulation similar to that of the second embodiment. Alternatively, one or more of the lα-previtamin D compounds of formulas (I) or (II) can be combined with one or more of the compounds of formulas (III) or (IV) in a delayed and sustained release formulation. The compounds of formulas (I) , (II) , (III) and (IV) are useful as active compounds in the pharmaceutical compositions of the above described embodiments. Such compositions may include physiologically acceptable excipients or vehicles. These pharmaceutical compositions constitute another aspect of the invention. The dosage forms may also contain adjuvants, such as preserving or stabilizing adjuvants. They may also contain other therapeutically valuable substances or may contain more than one of the compounds specified herein and in the claims in admixture. Advantageously, the compounds of formulas (I) , (II) , (III) and (IV) or combinations thereof together with other therapeutic agents can be orally administered in accordance with the above described embodiments in dosage amounts of from 0.1 to 100 micrograms per day. In relation to osteoporosis, doses from about 0.5 to about 25 micrograms per day are generally effective. If the compounds of the present invention are administered in combination with other therapeutic agents, the proportions of each of the compounds in the combination being administered will be dependent on the particular disease state being addressed. For example, in the case of osteoporosis, one may choose to administer the previtamin form of the activated vitamin D or the activated vitamin D compound with an estrogen compound, Calcitriol, Calcitonin or a bisphosphonate. In practice, higher doses of the compounds of the present invention are used where therapeutic treatment of a disease state is the desired end, while the lower doses are generally used for prophylactic purposes, it being understood that the specific dosage administered in any given case will be adjusted in accordance with the specific compounds being administered, the disease to be treated, the condition of the subject and the other relevant medical facts that may modify the activity of the drug or the response of the subject, as is well known by those skilled in the art. While the preferred embodiments are described above, it should be understood that the only limitation as to the kind of active vitamin D compound used in this invention is that the vitamin D compound binds with the vitamin D receptor protein. The embodiments of the present invention are further explained by the following examples which should not be construed by way of limiting the scope of the present invention. In the following examples, high pressure liquid chromatography (HPLC) was performed on a Waters Instrument, using a Zorbax Sil ODS column. Example l: Time course of lα-hydroxyprevitamin D conversion to lα-hydroxyvitamin D. One and a half micrograms of lα-hydroxyvitamin D 2 was dissolved in 2.00 ml ethanol. This solution was then subjected to a 60°C water bath for 24 hours. Fractions of lα-hydroxyprevitamin D 2 [lα-OH-pre-D 2 ] were collected in nearly pure amounts from this treated sample. These previtamin fractions were pooled in a single test tube, dried under nitrogen gas on ice and eventually redissolved in 1.00 ml ethanol. The pooled fraction of previtamin, upon HPLC analysis, indicated 96% was previtamin at t=0 time. A tube with the pooled previtamin was then placed in a 37°C water bath. 50 μl aliquots were removed and placed into LVI tubes with a cold water jacket around them. Samples were chromatographed to determine the percent of lα-hydroxyprevitamin D 2 and lα-0H-D 2 present in each sample. Sampling times were 0, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 6.0, and 8.0 hours. Results are presented below in Tables 1 and 2: TABLE 1 lα-OH-D-. SAMPLE PREPARATION SAMPLE % PREVITAMIN % lα-OH-D. Starting Material 0.00 99 24 hours at 60°C 8 92 Pooled Fractions 96 4 These results indicate that at normal body temperature, a 50% conversion of lα-hydroxyprevitamin D 2 to lα-hydroxyvitamin D 2 in vitro required approximately eight hours. In vivo one would expect a similar rate of conversion. These data indicate that thermal conversion at normal body temperature is sufficiently slow that most of the lα-hydroxyprevitamin D compound is absorbed into the blood stream in the previtamin form and conversion to the activated vitamin D counterpart occurs principally after absorption from the intestine. This results in a greater sustained blood level of activated vitamin D with less stimulation of intestinal calcium absorption than is seen with administering the corresponding activated vitamin D compound orally. Example 2: In vitro biological activity. lα,25-dihydroxyprevitamin D 3 or lα,25- dihydroxyvitamin D 3 were incubated with the vitamin D receptor protein and tracer amounts of 3 H-lα,25-(OH) 2 D 3 under standard conditions for a competitive binding assay. The amount of lα,25-dihydroxyprevitamin D 3 and lα,25-dihydroxyvitamin D 3 competitor was varied between 7.8 and 1000 pg or 1.0 and 25 pg, respectively. Concurrent with the incubations for binding, a tube of lα,25-dihydroxyprevitamin D 3 was incubated at the same temperature and for the same length of time to assess the amount of lα,25-dihydroxyprevitamin D 3 that had equilibrated to the vitamin form. HPLC analysis indicated that at the end of the incubation period approximately 2% of the lα,25-dihydroxyprevitamin D 3 had equilibrated to the vitamin form. The level of binding of the lα,25-dihydroxyprevitamin D 3 form was corrected for the amount of the vitamin form that had been generated during the assay procedure. TABLE 3 Binding of lα„25-dihydroxyprevitamin D 3 to Vitamin D Receptor in vitro The data shown in Table 3 above show that the lα,25-dihydroxyprevitamin D 3 form has an affinity for the receptor less than 0.01 the affinity of the lα,25- dihydroxyvitamin D 3 form, thus lα,25-dihydroxyprevitamin D 3 must equilibrate to the lα,25-dihydroxyvitamin D 3 form before it is biologically active. Example 3: Acute hypercalcemia testing. Male weanling rats are fed a vitamin D deficient diet containing normal Ca (0.47%) and P (0.3%). After approximately 4-6 weeks on this diet, the rats are separated into five groups and orally administered either lα,25-dihydroxyvitamin D 3 (0.06 or 0.12 ug/kg/day) or lα,25-dihydroxyprevitamin D 3 (0.06 or 0.12 ug/kg/day) in a vehicle such as lactose, or the vehicle alone (control) , for 3 days. All animals are exsanguinated 24 hours after the last dose and the blood is analyzed for serum calcium and serum phosphorus. The results demonstrate that dosing with lα,25-dihydroxyvitamin D 3 causes a greater rise in serum calcium and serum phosphorus than comparable dosing with lα,25-dihydroxy- previtamin D 3 . Example 4: Bioavailability testing. Male weanling rats are fed a diet deficient in vitamin D and with normal calcium (0.47%). After a period of four weeks has elapsed, the rats are divided into two groups, and orally administered either lα,25- dihydroxyprevitamin D 3 (0.25 /xg/kg) in a vehicle such as lactose or the vehicle (control) alone. Four hours after administration, the rats are killed and their blood level of lα,25-dihydroxyvitamin D 3 is measured using a standard technique. Following this procedure demonstrates that the blood level of lα,25-dihydroxyvitamin D 3 in rats that are administered lα,25-dihydroxyprevitamin D 3 is significantly elevated over the blood level of control animals. Example 5: In vivo biological activity testing. Male weanling rats were fed a vitamin D deficient diet containing normal Ca (0.47%) and P (0.3%). After three weeks on this diet, the rats were separated into four groups and orally administered 0.042, 0.250, or 1.50 μg/kg lα,25-dihydroxyprevitamin D 3 in a cold vehicle or the cold vehicle alone (control) for each of 14 days. Twenty-four hours after the last dose, the rats were killed and the blood calcium and lα,25-dihydroxyvitamin D 3 levels are measured. The blood calcium levels shown in the table below demonstrated that the serum calcium level was higher in the lα,25-dihydroxyprevitamin D 3 dosed animals than in the control animals, indicating that ultimately lα,25-dihydroxyprevitamin D 3 possesses biological activity. TABLE 4 Increase in Serum Calcium After lα,25-dihydroxyvitamin D 3 Administration This procedure also demonstrates that the serum lα,25- dihydroxyvitamin D 3 levels are higher in the lα,25- dihydroxyprevitamin D 3 dosed animals than in the control animals. Example 6: Pharmacokinetics testing. Male weanling rats are fed a vitamin D deficient diet containing normal Ca (0.47%) and P (0.3%). After four weeks on this diet, the rats are separated into seventeen groups and orally administered either lα,25- dihydroxyvitamin D 3 or lα,25-dihydroxyprevitamin D 3 in a vehicle such as lactose or the vehicle alone (control) . One group is killed 8 hours after dosing with the vehicle. Eight groups are orally administered a single dose of either lα,25-dihydroxyprevitamin D 3 or lα,25- dihydroxyvitamin D 3 and killed at 2, 4, 6, 9, 12, 18, 24, and 48 hours after dosing. The blood is collected and analyzed for lα,25-dihydroxyvitamin D 3 levels. The results demonstrate that dosing with lα,25- dihydroxyprevita in D 3 results in increased lα,25- dihydroxyvita in D 3 serum levels. The results further demonstrate that the increase in serum lα,25- dihydroxyvita in D 3 is more gradual and sustained for a greater duration than the lα,25-dihydroxyvitamin D 3 pharmacokinetics observed after dosing with lα,25- dihydroxyvitamin D 3 . Example 7: Treatment of osteoporosis. A clinical study is conducted with postmenopausal osteoporotic outpatients having ages between 55 and 75 years. The study involves up to 120 patients randomly divided into three treatment groups, and continues for 24 months. Two of the treatment groups receive constant dosages of orally administered lα,25- dihydroxyprevitamin D 3 (u.i.d.; two different dose levels above 0.5 μg/day) and the other group receives a matching placebo. All patients maintain a normal intake of dietary calcium (500 to 800 mg/day) and refrain from using calcium supplements. Efficacy is evaluated by pretreatment and posttreatment comparisons of the patient groups with regard to (a) total body, radial, femoral, and/or spinal bone mineral density as determined by x-ray absorptiometry (DEXA) , (b) bone biopsies of the iliac crest, and (c) determinations of serum osteocalcin. Safety is evaluated by comparisons of urinary hydroxyproline excretion, serum and urine calcium levels, creatinine clearance, blood urea nitrogen, and other routine determinations. This study demonstrates that patients treated with orally administered lα,25-dihydroxyprevitamin D 3 exhibit significantly higher total body, radial, femoral, and/or spinal bone densities relative to patients treated with placebo. The treated patients also exhibit significant elevations in serum osteocalcin. Bone biopsies from the treated patients show that lα,25-dihydroxyprevitamin D 3 stimulates normal bone formation. The monitored safety parameters confirm an insignificant incidence of hypercalcemia or hypercalciuria, or any other metabolic disturbance with lα,25-dihydroxyprevitamin D 3 . Example 8: Prevention of osteoporosis. A clinical study is conducted with healthy postmenopausal women having ages between 55 and 60 years. The study involves up to 80 patients randomly divided into two treatment groups, and continues for 12 to 24 months. One treatment group receives a constant dosage of lα,25-dihydroxyprevitamin D 3 (u.i.d.; a dose level above 0.5 μg/day) and the other receives a matching placebo. The study is conducted as indicated in Example 6 above. This study demonstrates that patients treated with lα,25-dihydroxyprevitamin D 3 exhibit reduced losses in total body, radial, femoral, and/or spinal bone densities relative to baseline values. In contrast, patients treated with placebo show significant losses in these parameters relative to baseline values. The monitored safety parameters confirm the safety of long- term lα,25-dihydroxyprevitamin D 3 administration at this dose level. Example 9: Prevention of hypocalcemia and bone loss in renal dialysis patients. A 12-month double-blind placebo-controlled clinical trial is conducted with 30 men and/or women with renal disease who are undergoing chronic hemodialysis. All patients enter an 8-week control period during which time they receive a maintenance dose of vitamin D 3 (400 IU/day) . After this control period, the patients are randomized into two treatment groups: one group receives a constant dosage of lα,25- dihydroxyprevitamin D 4 (u.i.d., a dosage greater than 3.0 μg/day) , and the other group receives a matching placebo. Both treatment groups receive a maintenance dosage of vitamin D 3 , maintain a normal intake of dietary calcium, and refrain from using calcium supplements. Efficacy is evaluated by pretreatment and posttreatment comparisons of the two patient groups with regard to (a) direct measurements of intestinal calcium absorption, (b) total body, radial, femoral, and/or spinal bone mineral density, and (c) determinations of serum calcium and osteocalcin. Safety is evaluated by regular monitoring of serum calcium. Analysis of the clinical data shows that lα,25- dihydroxyprevitamin D 4 significantly increases serum osteocalcin levels and intestinal calcium absorption, as determined by measurements using a single- or double- isotope technique. Patients treated with this compound show normalized serum calcium levels, stable values for total body, radial, femoral, and/or spinal bone densities relative to baseline values. In contrast, patients treated with placebo show frequent hypocalce ia, significant reductions in total body, radial, femoral, and/or spinal bone density. An insignificant incidence of hypercalcemia is observed in the treated group. Example 10: Treatment of psoriasis. An oral dosage formulation containing lα,24- dihydroxyprevitamin D 2 is evaluated in a double blind study for therapeutic efficacy of the formulation in the treatment of dermatitis (contact and ectopic) . The formulation evaluated contains 1.0 to 2.0 μg of lα,24- dihydroxyprevitamin D 2 . The control formulation is identical except that it does not contain the lα,24- dihydroxyprevitamin D 2 . The patients are treated in an outpatient clinic and are divided into an experimental and control population. They are instructed to take the medication once a day, in the morning before breakfast. In each patient (experimental and control) an area of the skin containing a lesion is selected which is ordinarily covered by clothing and the patients are instructed not to expose the skin area selected for study to sunlight. The area of the lesion is estimated and recorded, and the lesion(s) is photographed. Relevant details of the photographic procedure are recorded so as to be reproduced when the lesions are next photographed (distance, aperture, angle, background, etc.). Evaluations of erythema, scaling, and thickness are conducted at weekly intervals by a physician. The final evaluation is usually carried out at the end of four to six weeks of treatment. The results of the study show that daily oral administration of lα,24- dihydroxyprevitamin D 2 significantly reduces the degree of erythema, scaling, and thickness versus the control patients. Example 11: Formulation with equal parts Eudragit L100 and S100. An appropriate amount of activated vitamin D was dissolved in ethanol and combined with the matrix components listed in Table 5 and sprayed onto 850 g 25/30 mesh nonpariel beads. After drying, the beads were coated with the enteric coat listed in Table 5. TABLE 5 After formulation the beads (500 mg/capsule) are packaged in #0 gelatin capsules for administration to dogs. Dogs (Beagles, males and females, 13 kg and 9 kg, respectively) were administered 5 capsules/day of formulation. Blood is drawn for baseline determination, 24 hours after dosing but prior to subsequent dosing, and the serum calcium determined. Dose administration is terminated after 2 days with serum calcium levels significantly above normal. Five capsules/day of the above formulation (DSR-008) were administered to a female dog for 7 days. The normal serum calcium range in female dogs is 10.0 to 12.4 mg/dl with a mean of 11.2 mg/dl. The serum calcium at baseline of this experiment was 11.7 mg/dl; the subsequent values on successive days were as follows: 12.1, 12.3, 12.7, 13.1, 13.5, and 15.1 mg/dL. These results show that the biological activity of the drug in this formulation is revealed over a sustained period. Example 12: Formulation with unequal amounts Eudragit L100 and S90. An appropriate amount of activated vitamin D was dissolved in ethanol and combined with the matrix components listed in Table 6 and sprayed onto 850 g 25/30 mesh non-pariel beads. After drying, the beads were coated with the enteric coat listed in Table 6. TABLE 6 After formulation the beads (500 mg/capsule) are packaged in #0 gelatin capsules for administration to dogs. Dogs (as in Example 11) were administered 5 capsules/day of formulation. Blood is drawn for baseline determination, 24 hours after dosing but prior to subsequent dosing, and the serum calcium determined. Dose administration is terminated after 2 days with serum calcium levels significantly above normal. Five capsules/day of the above formulation (DSR-010) were administered to a female dog for 2 days. The normal serum calcium range in female dogs is 10.0 to 12.4 mg/dl with a mean of 11.2 mg/dl. The serum calcium at baseline was 10.9; the subsequent values on successive days were as follows: 13.8 and 16.1 mg/dl. These data show that the drug in this delayed release formulation is readily bioavailable. Example 13: Formulation with stearic acid matrix. An appropriate amount of activated vitamin D was dissolved in ethanol and combined with the matrix components listed in Table 7 and sprayed onto 850 g 25/30 mesh nonpariel beads. After drying, the beads were coated with the enteric coating listed in Table 7, TABLE 7 After formulation the beads (500 mg/capsule) are packaged in #0 gelatin capsules for administration to dogs. Dogs (as in Example 11) were administered 5 capsules/day of formulation. Blood is drawn for baseline determination, 24 hours after dosing but prior to subsequent dosing, and the serum calcium determined. Dose administration is terminated after 2 days with serum calcium levels significantly above normal. Five capsules/day of the above formulation (DSR-012) were administered to a male dog for 2 days. The normal serum calcium range in male dogs at this facility is 10.6 to 12.0 mg/dl with a mean of 11.3 mg/dl. The serum calcium at baseline was 11.4 mg/dl; the subsequent values on successive days were as follows: 14.2 and 15.5 mg/dl. These data illustrate that drug in this formulation is readily bioavailable in this delayed release formulation. Example 14: Pharmacokinetics testing. A dog receives a capsule of lα,25-dihydroxyvitamin D 3 drug formulated as illustrated in this invention (DSR) . Another dog receives a similar amount of the lα,25-dihdydroxyvitamin D 3 in fractionated coconut oil. Blood is drawn at O, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 15, 24, 36, and 72 hours after dose administration. The blood is analyzed for active vitamin D levels. The animal administered the drug in the capsule formulation shows a slower rise in blood concentration of active vitamin D, a lower maximum concentration of active vitamin D in the blood and prolonged elevation of active vitamin D blood level relative to the animal receiving the drug in fractionated coconut oil (FCO) . The graph below depicts the blood levels of active vitamin D expected from the above example. These procedures demonstrate that dosing animals with the formulation described in this invention results in lα,25-dihydroxyvitamin D 3 serum levels with a slower rise and longer duration than the lα,25-dihydroxyvitamin D 3 pharmacokinetics observed after dosing with lα,25- dihydroxyvitamin D 3 in fractionated coconut oil. Example 15: Delayed and sustained levels of active vitamin D in serum. Patients are administered two micrograms of calcitriol formulated as described in this invention. Blood samples collected 0, 2, 6, 8, and 12 hours after dose administration are analyzed for calcitriol levels. The results indicate that the levels of calcitriol at 2, 6, and 8 hours are increased over the level at 0, but are below levels considered hypercalcemic. These results indicate a delayed and sustained release of calcitriol. Example 16: Lack of toxic responses to active vitamin formulation. Patients are administered 2.0 micrograms of calcitriol formulated as described in this invention once daily for 7 days. An overnight urine collection after the last dose, and blood drawn 24 hours after the last dose are analyzed for calcium content. No hypercalcemia or hypercalciuria is observed, indicating low toxicity. Example 17: Treatment of osteoporosis. Postmenopausal osteoporotic women are administered 1.0 microgram of calcitriol formulated as described in this invention once daily for 2 years or placebo. The drug was well tolerated by the women and at the conclusion of the two years, bone mineral density was significantly greater in the women administered drug, and the rate of fractures was less in women administered the drug as compared to those administered placebo. Example 18: Treatment of psoriasis. A formulation of calcitriol as described in this invention is evaluated in a double blind study for therapeutic efficacy of the formulation in the treatment of dermatitis (contact and ectopic) . The formulation evaluated contains 0.5 to 2.0 μg of calcitriol. The control formulation is identical except that it does not contain the calcitriol. The patients are treated in an outpatient clinic and are divided into an experimental and control population. They are instructed to take the medication once a day. In each patient (experimental and control) an area of the skin containing a lesion is selected which is ordinarily covered by clothing and the patients are instructed not to expose the skin area selected for study to sunlight. The area of the lesion is estimated and recorded, and the lesion(s) is photographed. Relevant details of the photographic procedure are recorded so as to be reproduced when the lesion(s) are next photographed (distance, aperture, angle, background, etc.) Evaluations of erythema, scaling, and thickness are conducted at weekly intervals by a physician. The final evaluation is usually carried out at the end of four to six weeks of treatment. The results of the study show that daily oral administration of calcitriol in this formulation does not produce clinicaly significant hypercalcemia or hypercalciuria and significantly reduces the degree of erythema, scaling, and thickness versus the control patients. In summary, the present invention provides methods for ameliorating certain medical conditions by improving blood levels of activated vitamin D. The improved levels are achieved by administration of an oral formulation of lα-hydroxyprevitamin D or DSR activated vitamin D or combination thereof. The formulations of the invention significantly reduce the risk of hypercalcemia and hypercalciuria associated with heretofore known formulations of activated vitamin D. Furthermore, the formulation of the invention produces higher levels of activated vitamin D for a greater sustained time per administration than is obtained with heretofore known oral formulations of activated vitamin D. While the present invention has now been described and exemplified with some specificity, those skilled in the art will appreciate the various modifications, including variations, additions, and omissions, that may be made in what has been described. Accordingly, it is intended that these modifications also be encompassed by the present invention and that the scope of the present invention be limited solely by the broadest interpretation that lawfully can be accorded the appended claims.

Claims: CLAIMS : 1. A pharmaceutical composition comprising the compound of formula (I) : (I) wherein R, is a branched or unbranched, saturated or unsaturated, unsubstituted or substituted, cyclic or noncyclic side chain having at least 7 carbon atoms and wherein the thermal isomer of said compound increases the serum calcium of vitamin D deficient subjects. 2. A method for increasing the blood level of activated vitamin D in an animal or human being, comprising administering orally to the animal or human being an effective amount of lα-hydroxyprevitamin D. 3. A method as claimed in claim 2, further comprising sustaining the blood level of activated vitamin D for a defined period of time. 4. A method as claimed in claim 3, wherein said defined period of time is greater than four hours. 5. The method of claim 2, wherein said lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 3 . 6. The method of claim 4, wherein said lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 3 . 7. The method of claim 2, wherein said lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 2 . 8. The method of claim 4, wherein said lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 2 . 9. The method of claim 2, wherein said lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 4 . 10. The method of claim 4, wherein said lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 4 . 11. The method of claim 2, wherein said amount of lα-hydroxyprevitamin D administered is from about 0.1 μg/day to about 100 μg/day. 12. A method for treating osteoporosis in a human being, comprising administering orally to said human being a effective amount of lα-hydroxyprevitamin D. 13. The method of claim 12, wherein the lα- hydroxyprevitamin D is lα,25-dihydroxyprevitamin D 3 . 14. A method for treating psoriasis in a human being, comprising administering orally to said human being an effective amount of lα-hydroxyprevitamin D. 15. The method claim 14, wherein the lα- hydroxyprevitamin D is lα,24-dihydroxyprevitamin D 2 . 16. A pharmaceutical composition comprising the compound of formula (II) : (ID wherein B and C are either hydrogen or a carbon to carbon bond forming a double bond between 022 and 023; Rj, R 3 , R,, and R 5 are each independently hydrogen, hydroxy, lower alkyl, O-lower alkyl, O-lower acyl, O-aromatic acyl or flouro; and R 2 is hydrogen or lower alkyl; and a pharmaceutically acceptable excipient. 17. The pharmaceutical composition of claim 16, wherein said compound is selected from the group consisting of lα,25-dihydroxyprevitamin D 3 , lα,25- dihydroxyprevitamin D 2 , or lα,25-dihydroxyprevitamin D 4 . 18. The pharmaceutical composition of claim 16, wherein said compound is in a heat stable form. 19. The pharmaceutical composition of claim 18, wherein said heat stable form is a crystalline form. 20. A method of treating osteoporosis, comprising administering orally to a patient an amount effective to increase blood level of activated vitamin D of a compound of formula (II) : ( D wherein B and C are either hydrogen or a carbon to carbon bond forming a double bond between C22 and 023; Rj, R 3 , R 4 and R 5 are each independently hydrogen, hydroxy, lower alkyl, O-lower alkyl, O-lower acyl. O-aromatic acyl or fluoro; and R 2 is hydrogen or lower alkyl; and continuing said administrating step until bone mass increases and the patient's calcium balance becomes positive and indicates mineral accumulation in the skeleton. 21. The method of claim 20, wherein said administering step further comprises administering said compound in a heat stable, crystalline form. 22. An oral medicament for use in a human being having a stomach and intestine, said oral medicament comprising: a matrix containing a vitamin D compound in a unit dosage amount, said matrix having means for releasably binding said active vitamin D and said matrix having means for controlled release of said activated vitamin D over a sustained period of time, said viatmin D compound selected from the group consisting of activated vitamin D and lα-hydroxyprevitamin D. 23. An oral medicament as described in claim 22, further comprising: an enteric coating which covers said matrix and prevents release of said activated vitamin D, said matrix being resistant to dissolution in said stomach but predisposed to dissolution in the environment of said intestine so as to prevent release of said activated vitamin D from said matrix until said medicament is in said intestine. 24. An oral medicament for use in a human being having a gastrointestinal tract including a stomach and small intestine, said small intestine having a proximal, middle and distal portion, said oral medicament comprising: an enteric coating and a matrix containing a vitamin D compound in unit dosage amount, said matrix having means for releasably binding said vitamin D compound and for controlled release of said vitamin D compound over a sustained period of time when exposed to the environment of said gastrointestinal tract, said enteric coating covering said matrix and preventing release of said vitamin D compound from said matrix, said enteric coating being resistant to dissolution in said stomach but predisposed to dissolution in the environment of said intestine so as to prevent release of said vitamin D compound from said matrix until said medicament is in said intestine, said vitamin D compound selected from the group consisting of activated vitamin D and lα-hydroxyprevitamin D. 25. An oral medicament as claimed in claim 24, wherein said enteric coating is further resistant to dissolution in the proximal portion of said small intestine but predisposed to dissolution in the middle and distal portion of said small intestine so as to prevent release of said vitamin D compound from said matrix until said medicament has traveled to the middle portion of said small intestine. 26. An oral medicament as claimed in claim 23 or 24, wherein in said enteric coating is resistant to dissolution in an environment having a pH less than 6.0. 27. An oral medicament as claimed in claim 23 or 24, wherein said enteric coating is a cellulose, acetate-like polymer. 28. An oral medicament as claimed in claims 22, 23 or 24 wherein said vitamin D compound is lα,25-dihydroxy vitamin D 3 . 29. An oral medicament for use in a human being having a stomach and small intestine, said small intestine having a proximal, middle and distal portion, and said human being displaying or predisposed to loss of bone mass, said medicament, comprising: a matrix containing lα,25-dihydroxy vitamin D 3 in unit dosage form and an enteric coating covering said matrix, said enteric coating being resistant to dissolution in an environment having a pH less than 6.0 but predisposed to dissolution in an environment having a pH above 6.0, said matrix having a means for releasably binding said lα,25-dihydroxy vitamin D 3 and for controlled release of said lα,25-dihydroxy vitamin D 3 when said enteric coating is dissolved and said matrix is exposed to the environment of said intestine. 30. A method for treating or preventing loss of bone mass or bone mineral content in a human being displaying or predisposed to osteoporosis, said human being having a stomach and intestine, said method comprising: the step of administering orally to said human an oral medicament comprising a matrix containing a vitamin D compound, said matrix having means for releasably binding said active vitamin D and said matrix having means for controlled release of said vitamin D compound over a sustained period of time, said vitamin D compound selected from the group consisting of activated vitamin D and lα-hydroxyprevitamin D. 31. A method for treating or preventing loss of bone mass as claimed in claim 30, wherein said oral medicament further comprises an enteric coating which covers said matrix and prevents release of said vitamin D compound, said matrix being resistant to dissolution in said stomach but predisposed to dissolution in the environment of said intestine so as to prevent release of said vitamin D compound from said matrix until said medicament is in said intestine. 32. A method for treating or preventing loss of bone mass as claimed in claim 30, wherein said vitamin D compound is lα,25 dihydroxy vitamin D 3 . 33. A method for treating or preventing psoriasis in a human being displaying or predisposed to psoriasis, said method comprising: the step of administering orally to said human being an oral medicament comprising a matrix containing a vitamin D compound, said matrix having means for releasably binding said active vitamin D and said matrix having means for controlled release of said vitamin D compound over a sustained period of time, said vitamin D compound selected from the group consisting of activated vitamin D and lα-hydroxyprevitamin D. 34. A method for treating psoriasis as claimed in claim 33, wherein said oral medicament further comprises an enteric coating which covers said matrix and prevents release of said vitamin D compound, said matrix being resistant to dissolution in said stomach but predisposed to dissolution in the environment of said intestine so as to prevent release of said vitamin D compound from said matrix until said medicament is in said intestine. 35. A method for treating psoriasis as claimed in claim 33, wherein said vitamin D compound is lα,25-dihydroxyvitamin D 3 .

Inventors: BISHOP CHARLES W, KNUTSON JOYCE C, VALLIERE CHARLES R, BISHOP, CHARLES, W., KNUTSON, JOYCE, C., VALLIERE, CHARLES, R.
Applicants: BISHOP CHARLES W, KNUTSON JOYCE C, LUNAR CORP, VALLIERE CHARLES R, LUNAR CORPORATION
Application year: 1993
Main classification: A61K31
IPC codes: A61K9, A61K31, A61K33, A61K38, A61K47, A61P3, A61P17, A61P19, A61P43