4,5,6,7-Tetrahydro-1H-imidazo 4,5-c pyridine-6-carboxylic acid amide derivatives as angiotensine II antagonistes

Abstract: A compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein R¹ represents hydrogen, halogen, C₁-C₆ alkyl, C₃-C₆ alkenyl, C₃-C₆ alkynyl, R²⁰(CH₂) n - wherein R²⁰ represents C₃-C₈ cycloalkyl , naphthyl, phenyl, or phenyl substituted with one to five of C₁-C₄ alkyl, halogen atom, trifluoromethyl, hydroxy, C₁-C₄ alkoxy, C₁-C₃ acyloxy, amino, N-mono-C₁-C₄ alkylamino, N-di-C₁-C₄ alkylamino, C₁-C₄ thioalkyl, C₁-C₃ alkylsulfonyl, nitro, and -NHCOR²¹ wherein R²¹ represents C₁-C₃ alkyl, phenyl, C₁-C₃ alkylphenyl, aminophenyl, or C₁-C₄ alkylaminophenyl, and n is an integer of 1 to 6, R²⁰-C(O)- wherein R²⁰ is as defined above, or R²⁰-CH(OH)- wherein R²⁰ is as defined above; R² represents carbamoyl, mono- or di-C₁-C₆ alkylcarbamoyl, or 4- to 6-membered heterocyclic carbamoyl; R represents amino, carboxy, (1H-tetrazol-5-yl)phenyl, carboxyphenyl, carboxybenzamido, (1H-tetrazol-5-yl)benzamido, carboxyphenylcarbamoyl, or (1H-tetrazol-5-yl)-phenylcarbamoyl; R³ represents -CH₂(phenyl), -CH(phenyl)₂, -CH(phenyl)CH₃, -CH(phenyl) (cyclohexyl), -CH₂CH₂(phenyl), -CH₂(C₁-C₆ alkoxyphenyl), or -CH₂(hydroxyphenyl); and R⁴, R⁷, and R⁸ each independently represents hydrogen or C₁-C₆ alkyl, is an angiotensin II antagonist.

Description: The present invention relates to 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid amide derivatives, intermediates for preparing the derivatives, and antagonists against angiotensin II (AII) comprising the derivatives. Angiotensin II is an octapeptide hormone typically relating to hypertension and central nervous system diseases. It is therefore known that inhibition of the activities of angiotensin II is effective for the treatment of hypertension and central nervous system diseases. As angiotensin II inhibitors, there have been developed a renin inhibitor and an angiotensin-converting enzyme (ACE) inhibitor which inhibit the synthesis of angiotensin II-These inhibitors, however, have the problems that they are incapable of inhibiting the activities of angiotensin produced by other types of enzymes than renin and ACE, and that they may exert adverse effects on other metabolic systems. Angiotensin II acts through interaction with a specific receptor present in a cell membrane, so that an angiotensin II receptor antagonist which is capable of inhibiting all of the actions of the generated angiotensin II at the level of interaction with the receptor and does not influence other metabolic systems has been desired as an antagonistic agent which is more specific and has less side effects. Some peptide analogs such as Saralasin have been reported as angiotensin II receptor antagonists, but they are unsatisfactory in their antagonistic activities and also the area of their applications is limited because of their lack of oral absorptivity. Recently, non-peptidic angiotensin II receptor antagonists have been reported as agents free of said problems. Examples of these antagonists are DuP753, PD123177 (Bio-organic & Medical Chemistry Letters, 1(12), 711-716, 1991) and 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid derivatives disclosed in US-A-5,091,390, which are represented by the following structural formulae (1), (2), and (3), respectively: wherein, for example, R 1 is hydrogen, R 2 is CO 2 H, R 3 is COCH(Ph) 2 , X is NHCO, R 4 is CO 2 H, and R 6 is CH 3 . Nevertheless, there is still desired a compound having a higher specificity to the angiotensin II receptors and a higher antagonistic activity against angiotensin II. The present inventors have found that some specific 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid amide derivatives have a noticeably high antagonistic activity against angiotensin II and a high specificity to angiotensin II receptors as compared with the known compounds. Based on this finding, the present invention has been attained. In a first aspect of the present invention, there is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein R 1 represents hydrogen, halogen, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, R 20 (CH 2 ) n - wherein R 20 represents C 3 -C 8 cycloalkyl, naphthyl, phenyl, or phenyl substituted with one to five Of C 1 -C 4 alkyl, halogen atom, trifluoromethyl, hydroxy, C 1 -C 4 alkoxy, C 1 -C 3 acyloxy, amino, N-mono- C 1 -C 4 alkylamino, N-di-C 1 -C 4 alkylamino, C 1 -C 4 thioalkyl, C 1 -C 3 alkylsulfonyl, nitro, and -NHCOR 21 wherein R 21 represents C 1 -C 3 alkyl, phenyl, C 1 -C 3 alkylphenyl, aminophenyl, or C 1 -C 4 alkylaminophenyl, and n is an integer of 1 to 6, R 20 -C(O)- wherein R 20 is as defined above, or R 20 -CH(OH)- wherein R 20 is as defined above; R 2 represents carbamoyl, mono- or di-C 1 -C 6 alkylcarbamoyl, or 4- to 6-membered heterocyclic carbamoyl; R represents amino, carboxy, (1H-tetrazol-5-yl)phenyl, carboxyphenyl, carboxybenzamido, (1H-tetrazol-5-yl)benzamido, carboxyphenylcarbamoyl, or (1H-tetrazol-5-yl)phenylcarbamoyl; R 3 represents -CH 2 (phenyl), -CH(phenyl) 2 , -CH(phenyl)CH 3 , -CH(phenyl) (cyclohexyl), -CH 2 CH 2 (phenyl), -CH 2 (C 1 -C 6 alkoxyphenyl), or -CH 2 (hydroxyphenyl); and R 4 , R 7 , and R 8 each independently represents hydrogen or C 1 -C 6 alkyl. The present invention also provides intermediates used in the process for producing the compound of formula (I). Thus, in a second aspect of the present invention there is provided a compound of formula (XXX): or a salt thereof, wherein R, R 4 , R 7 and R 8 are as defined above; R 3' represents hydrogen, -COCH 2 (phenyl), -COCH(phenyl) 2 , -COCH (phenyl) CH 3 , -COCH(phenyl) (cyclohexyl), -COCH 2 CH 2 (phenyl), -COCH 2 (C 1 -C 6 alkoxyphenyl), or -COCH 2 (hydroxyphenyl) ; R 6 is nitro, (1-triphenylmethyl-1H-tetrazol-5-yl)phenyl, cyano, 2-(1-triphenylmethyl-1H-tetrazol-5-yl)phenyl, C 1 -C 3 alkoxycarbonyl, cyanophenyl or 2-cyanophenyl; and R 15 ' represents -CH 2 -R 19 or -C(O)-R 19 wherein R 19 represents hydrogen or C 1 -C 6 alkyl. In a third aspect of the present invention there is provided a compound of formula (XIII) : or a salt thereof; wherein R 1 , R 3 , R 4 , R 6 , R 7 and R 8 are as defined above; and R 2' represents amino, mono or di-C 1 -C 6 alkylamino, or 4- to 6-membered heterocyclic amino. In a fourth aspect of the present invention there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in a method of treatment of the human or animal body by therapy, in particular for use as an angiotensin II antagonist. In a fifth aspect of the present invention there is provided the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as an angiotensin II antagonist. In a sixth aspect of the present invention there is an angiotensin II antagonist composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent. In a seventh aspect of the present invention there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof with the proviso that R 1 is not hydrogen for use as an angiotensin II AT receptor antagonist, or a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein R 1 is hydrogen for use as an angiotensin II AT 2 receptor antagonist. In an eighth aspect of the present invention there is provided a process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof which comprises: (i) reacting a compound of formula (II): wherein R 1 , R 3 , R 4 , R 7 and R 8 are as defined above and R 2' is amino, mono- or di-C 1 -C 6 alkylamino, or 4- to 6- membered heterocyclic amino, or a salt thereof, with an appropriate benzoic acid derivative at 10 to 40°C for 10 to 24 hours; (ii) hydrolysing a compound of formula (XIII) or a salt thereof wherein R 6 is cyanophenyl; (iii) reacting a compound of formula (IV): wherein R 1 , R 3 , R 4 , R 7 and R 8 are as defined above and R 6 is (1H-tetrazol-5-yl)phenyl or a salt thereof with an appropriate nitrogen-containing compound at 10 to 40°C for 10 to 24 hours; (iv) reacting a compound of formula (XIII) or a salt thereof wherein R 6 is C 1 -C 3 alkoxycarbonyl with an alkali at 10 to 40°C for 1 to 24 hours; (v) reacting a compound of formula (XIII) or a salt thereof wherein R 6 is nitro with tin chloride or tin chloride dehydrate under an inert gas atmosphere at 10 to 100°C for 0.1 to 1 hour; (vi) reacting a compound of formula (XIII) or a salt thereof wherein R 6 is cyanophenyl with trimethyltin azide or tributyltin azide under an inert gas atmosphere at 100 to 120°C for 12 to 120 hours followed by treatment with an acid; or (vii) reacting a compound of formula (XIII) or a salt thereof wherein R 6 is ((1-triphenylmethyl)-1H-tetrazol-5-yl)phenyl with an acid at 10 to 100°C for 0.1 to 6 hours; and, if desired, converting a compound of formula (I) into another compound of formula (I), and/or, if desired, converting a compound of formula (I) into a pharmaceutically acceptable salt thereof, and/or, if desired, coverting a salt into a free compound. The compound of formula (I) and the pharmaceutically acceptable salts thereof have a noticeably high antagonistic activity against angiotensin II and a high specificity to angiotensin II receptors. Preferably R 1 is hydrogen or C 1 -C 6 alkyl; R 2 is -CONH 2 ,-CONHCH 3 , -CON(CH 3 ) 2 , -CONH(C 2 H 5 ), -CON(C 2 H 5 ) 2 , R is amino, carboxy, 2-(1H-tetrazol-5-yl)phenyl, 2-carboxyphenyl, 2-carboxybenzamido, 2-(1H-tetrazol-5-yl)benzamido, 2-carboxyphenylcarbamoyl, or 2-(1H-tetrazol-5-yl) phenylcarbamoyl; R 3 is -CH(phenyl) 2 , -CH 2 (phenyl), -CH(phenyl)CH 3 , -CH(phenyl) (cyclohexyl), -CH 2 CH 2 (phenyl), -CH 2 (p-methoxyphenyl), or -CH 2 (p-hydroxyphenyl); and R 4 , R 7 , and R 8 are each independently hydrogen or C 1 -C 2 alkyl. The compound of the present invention has an asymmetric carbon atom at the 6-position of the condensed imidazole ring. Accordingly, the present invention includes any single stereoisomer thereof and a mixture of stereoisomers. Preferably, the compound of the present invention is a stereoisomer in which the 6-position of the condensed imidazole ring has the S configuration. The pharmaceutically acceptable salt of the compound of the present invention can be obtained by using an acid or a base which is commonly employed in the field of pharmacy. Preferred examples of the acid include organic and inorganic acids such as hydrochloric acid, sulfuric acid, methanesulfonic acid, benzenesulfonic acid, and p-toluenesulfonic acid. Preferred examples of the organic base include mono-, di-, or trialkylamines such as methylamine, dimethylamine, and triethylamine, and mono-, di-, or trihydroxyalkylamines such as mono-, di-, or triethanolamine. Preferred examples of the inorganic base include hydroxides, carbonates, and bicarbonates of, for example, ammonium, sodium, lithium, potassium, calcium, magnesium, aluminum, and zinc. The term "halogen" used herein means fluorine, chlorine, bromine, and iodine. In the present invention, the phenyl having a substituent may have its substituent or substituents at any of the o-, m-, and p-positions unless otherwise specified. An example of a process for preparing a compound of the present invention (hereinafter called process A) is shown in Scheme I. With reference to Scheme I, the process A is described by dividing the process into ten steps (1)-(10). Step (1) A compound of formula (XI) wherein R 1 is as defined above and Boc is tertiary butoxycarbonyl, is reacted with a compound of the formula (X) wherein Y is OH, R 1 , Br, or OSO 2 CF 3 ; R 4 is H or C 1 -C 6 alkyl; R 6 is NO 2 , cyanophenyl, cyano, (1H-tetrazol-5-yl)phenyl, or C 1 -C 3 alkoxycarbonyl; and R 7 and R 8 are each independently H or C 1 -C 6 alkyl, at 0 to 60°C for 10 to 48 hours to obtain a compound of formula (IX) wherein R 1 , R 4 , R 6 , R 7 , R 8 , and Boc are as defined above. Step (2) The compound of formula (IX) obtained in step (1) is treated with an acid, such as hydrochloric acid, to obtain a compound of formula (VIII) wherein R 1 , R 4 , R 6 , R 7 , and R 8 are as defined above. Step (3) To the compound of formula (VIII), there are added an acid and HCHO, and the mixture is reacted at 10 to 150°C for 0.5 to 4 hours to obtain a compound of formula (VII) wherein R 1 , R 4 , R 6 , R 7 , and R 8 are as defined above. Step (4) The compound of formula (VII) is suspended in an alcohol/trimethyl orthoformate mixture and HCl is then blown into the suspension to carry out reaction at 60 to 100°C for 4 to 8 hours to obtain a compound of formula (VI) wherein R 1 , R 4 , R 6 , R 7 , and R 8 are as defined above. Step (5) The compound of formula (VI) is added to a solution of acetonitrile, chloroform, dimethylformamide, or THF containing carbodiimide, l-hydroxybenztriazole, diphenylacetic acid, or phenylcyclohexylacetic acid and reacted at 10 to 40°C for 10 to 48 hours to obtain a compound of formula (V) wherein R 1 , R 4 , R 6 , R 7 , and R 8 are as defined above; and R 3 is -CH(phenyl) 2 , -CH(phenyl)(cyclohexyl), -CH 2 (phenyl), -CH 2 CH 2 (phenyl), -CH(phenyl)CH 3 , -CH 2 (C 1 -C 6 alkoxyphenyl), or -CH 2 (hydroxyphenyl). Step (6) An alkali, e.g. NaOH, is added to the compound of formula (V) to obtain a compound of formula (IV) wherein R 1 , R 3 , R 4 , R 6 , R 7 , and R 8 are as defined above. Step (7) A nitrogen-containing compound is added to the compound of formula (IV) and the mixture is reacted at 10 to 40°C for 10 to 24 hours to obtain a compound of the formula (III) wherein R 1 , R 3 , R 4 , R 6 , R 7 , and R 8 are as defined above; and R 2' is amino, mono- or di-C 1 -C 6 alkylamino, or 4- to 6-membered heterocyclic amino. When R 6 is (1H-tetrazol-5-yl)phenyl, a compound of formula (I) wherein R is (1H-tetrazol-5-yl)phenyl, is obtained in this step. Step (8) Tin chloride dihydrate is added to the compound of formula (III) wherein R 6 is NO 2 and the mixture is reacted at 40 to 100°C for 10 to 120 minutes to obtain a compound of the formula (II) wherein R 1 , R 2' , R 3 , R 4 , R 7 , and R 8 are as defined above. Step (9) A benzoic acid derivative is reacted with the compound of formula, (II) at 10 to 40°C for 10 to 24 hours to obtain a compound of formula (I) wherein R 1 , R 2' , R 3 , R 4 , R 7 , and R 8 are as defined above. Step (10) When R 6 is cyanophenyl, there can be obtained a compound of formula (I) wherein X is a C-C single bond, by hydrolyzing the compound of formula (III). A compound of formula (XI) (raw material) can be obtained by the method described in J. Am. Chem. Soc., 114 (5), 1906-1908, 1992. A compound of formula (X) (raw material) can be obtained, for example, by the method described in J. Med. Chem., 33, 1312-1329, 1990, J. Med. Chem., 34, 2525-2547, 1991, J. Med. Chem., 34, 3248-3260, 1991, etc. Conversion of substituents may be made by the conventional methods available to one ordinarily skilled in the art. Another example of a process for producing the compound of the present invention (hereinafter referred to as process B) is described in Scheme II. With reference to Scheme II the process B is described by dividing the process into 19 steps (a)-(s). Step (a) A compound of formula (XXIII) is reacted with a tertiary amine such as Tr (triphenylmethyl) chloride and triethylamine in a solvent such as ether, THF (tetrahydrofuran), dioxane, methylene chloride, and chloroform at 10 to 60°C for 2 to 24 hours to obtain a compound of formula (XXII). The compound of formula (XXIII) is commercially available. Step (b) The compound of formula (XXII) is reacted with a reducing agent such as lithium aluminum hydride in a solvent such as ether, THF, and dioxane at 0 to 40°C for 0.1 to 1 hour to obtain a compound of formula (XXI). Step (c ) The compound of formula (XXI) is reacted with TBDMS (tertiary butyldimethylsilyl) chloride and imidazole in a solvent such as DMF (dimethylformamide) at 0 to 40°C for 0.5 to 6 hours to obtain a compound of formula (XX). Step (d) The compound of formula (XX) is dissolved in a solvent such as ether, THF, and dioxane in an atmosphere of an inert gas such as nitrogen or argon, and reacted with a R 1 halide (wherein R 1 is as defined above and the halide is chloride, bromide, or iodide) in the presence of a base such as butyl lithium (normal, secondary, or tertiary) and HMPA (hexamethylphosphoramide) at 0 to 40°C for 0.1 to 6 hours to obtain a compound of the formula (XIX). Step (e) An acid such as hydrochloric acid, is added to the compound of formula (XIX) and the mixture is reacted at 10 to 120°C for 0.5 to 6 hours to obtain a compound of formula (XVIII). This compound may be isolated. When it is not isolated, an aqueous HCHO solution is directly added thereto, and the mixture is reacted at 10 to 120°C for 0.5 to 6 hours to obtain a compound of formula (XVII). Step (f) The compound of formula (XVII) is added to a solution of acetonitrile, chloroform, or THF containing carbodiimide, 1-hydroxybenztriazole, and R 3 COOH, and reacted at 10 to 60°C for 1 to 48 hours to obtain a compound of formula (XVI). Step (g) The compound of formula (XVI) and a compound of formula the formula (X) are reacted in a solvent such as acetone, DMF, ether, THF, and chloroform in the presence of an appropriate base such as anhydrous potassium carbonate at 10 to 60°C for 1 to 48 hours to obtain a compound of formula (XV). Step (h) The compound of formula (XV) is reacted with an oxidizing agent such as chromic acid in a solvent such as acetone, methylene chloride, and chloroform at 10 to 40°C for 0.1 to 3 hours to obtain a compound of the formula (XIV). Step (i) The compound of formula (XIV) is added to a solution of acetonitrile, chloroform, or THF containing carbodiimide, 1-hydroxybenztriazole, and linear or cyclic alkylamine, and reacted at 10 to 60°C for 1 to 48 hours to obtain a compound of formula (XIII). Step (j) When R 6 is methoxycarbonyl, an alkali such as sodium hydroxide is added to a solution of the compound of formula (XIV) in an alcohol, ether, THF, or a mixture thereof, and reacted at 10 to 40°C for 1 to 24 hours to obtain a compound of formula (I') wherein R 10 is carboxy. Step (k) When R 6 is nitro, tin chloride or tin chloride dihydrate is added to a solution of the compound of formula (XIII) in ethyl acetate, an alcohol, or a mixture thereof, and reacted in an atmosphere of an inert gas such as nitrogen or argon at 10 to 100°C for 0.1 to 1 hour to obtain a compound of formula (I') wherein R 10 is amino. Step (1) When R 6 is cyanophenyl, trimethyltin azide or tributyltin azide is added to a solution of the compound of formula (XIII) in toluene or xylene, and the mixture is reacted in an atmosphere of an inert gas such as nitrogen or argon at 100 to 120°C for 12 to 120 hours, followed by a treatment with an acid such as hydrochloric acid to obtain a compound of formula (I) wherein R 10 is 1H-tetrazol-5-yl)phenyl. Step (m) When R 6 is ((1-triphenylmethyl)-1H-tetrazol-5-yl)phenyl, the compound of the formula (XIII) is dissolved in a solvent such as THF and dioxane, and an acid such as hydrochloric acid is added to the solution. Then, the mixture is reacted at 10 to 100°C for 0.1 to 6 hours to obtain a compound of formula (I) wherein R 10 is (1H-tetrazol-5-yl)phenyl. Step (n) When R 10 is carboxy or amino, the compound of formula (I') is dissolved in a solvent such as chloroform, acetonitrile, THF, and dioxane, and reacted by adding a compound having a required group at 10 to 60°C for 1 to 24 hours to obtain a compound of the formula (I). Step (o) The compound of formula (XIX) is dissolved in a solvent such as THF and ether, and reacted with tetra-n-butylammonium fluoride at 0 to 40°C for 0.5 to 6 hours to obtain a compound of formula (XXIV). Step (p) The compound of formula (XXIV) is dissolved in DMF, and reacted with PDC (pyridinium dichromate) at 0 to 40°C for 0.5 to 24 hours to obtain a compound of formula (XXV) . Step (q) An acid such as hydrochloric acid is added to the compound of formula (XXV) and mixture is reacted at 10 to 120°C for 0.5 to 6 hours to obtain a compound of the formula (XXV'). This compound (XXV') may be isolated. When it is not isolated, an HCHO solution is directly added thereto and the mixture is reacted at 10 to 120°C for 0.5 to 6 hours to obtain a compound of formula (XXVI). Step (r) The compound of formula (XXVI) is added to a solution of acetonitrile, chloroform, or THF containing carbodiimide, dimethylformamide, 1-hydroxybenztriazole, and R 3 COOH, and reacted at 10 to 60°C for 1 to 48 hours to obtain a compound of formula (XXVII). Step (s) The compound of formula (XXVII) is reacted with a compound of formula (X) in a solvent such as acetone, DMF, ether, THF, and chloroform in the presence of an appropriate base such as anhydrous potassium carbonate at 10 to 60°C for 1 to 48 hours to obtain a compound of formula (XIV). The compound of formula (X) can be obtained, for instance, by a method described in J. Med. Chem., 34, 2525-2547, 1991, or J. Med. Chem., 35, 4027-4038, 1992. In preferred compounds of formula (XIII') R 1 is hydrogen or C 1 -C 6 alkyl; R 4 is hydrogen atom or C 1 -C 2 alkyl; R 6 is nitro, 2-(1-trifluoromethyl-1H-tetrazol-5-yl)phenyl, or 2-cyanophenyl; R 7 and R 8 are each independently hydrogen or C 1 -C 6 alkyl; and R 10 is hydrogen or C 1 -C 6 alkyl. In preferred compounds of formula (XXIX), preferably R 1 is hydrogen atom or C 1 -C 6 alkyl; R 15 is -COOH; and R 3' is -COCH(phenyl) 2 or -COCH(phenyl) (cyclohexyl). In the formula (XXIX), R 1 is hydrogen or C 1 -C 6 alkyl; R 15 is -COOH; and R 3' is -COCH(phenyl) 2 or -COCH(phenyl) (cyclohexyl). In preferred compounds of formula (XXX), R 1 is hydrogen or C 1 -C 6 alkyl; R 3' is -COCH(phenyl) 2 or -COCH(phenyl) (cyclohexyl); R 6 is nitro, 2-(1-triphenyl methyl-1H-tetrazol-5-yl)phenyl, cyano, methoxycarbonyl, or 2-cyanophenyl; R 4 , R 7 and R 8 are each independently hydrogen or C 1 -C 2 alkyl; and R 19 is hydrogen or C 1 -C 2 alkyl. In the preferred compounds of formula (XIII), R 1 is hydrogen or C 1 -C 6 alkyl; R 2 is -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NH(C 2 H 5 ), N(C 2 H 5 ) 2 or R 3 is -CH(phenyl) 2 , or -CH(phenyl)(cyclohexyl); R 4 , R 7 , and R 8 are each independently hydrogen atom or C 1 -C 2 alkyl; and R 6 is nitro, 2-(1-triphenylmethyl-1H-tetrazol-5-yl)phenyl, methoxycarbonyl, cyano, or 2-cyanophenyl. The intermediate compounds of the present invention each have an asymmetric carbon atom at the 6-position of the condensed imidazole ring or the corresponding position. These intermediate compounds, therefore, include the single stereoisomer thereof and a mixture of stereoisomers. In the present invention, these intermediate compounds are preferably the stereoisomers in which the 6-position of the condensed imidazole ring or the corresponding position has the S configuration. The salts of the above intermediate compounds can be obtained by using an acid or a base which is capable of chemically forming a salt with the intermediate compounds. Formula (XIII') includes formulae (IX) and (VIII) in process A and formula (XXVIII) includes formulae (XVIII), (XIX), (XXIV), (XXV), and (XXIII) in process B. Formula (XXIX) includes the formulae (XVII), (XVI), (XXVI), and (XXVII) in process B, and formula (XXX) includes formulae (VII), (VI), (V), and (IV) in process B. Therefore, these intermediate compounds can be produced according to process A or B. The compound of the present invention produces its pharmacological effect by competing with the receptor of angiotensin II and thereby inhibiting or suppressing the action of angiotensin II. Particularly, the compound competes specifically with the AT 1 receptor (when R 1 in formula (I) is not hydrogen) and the AT 2 receptor (when R 1 is hydrogen), which are known as angiotensin II receptors. Also, as apparent from the Examples described later, the compound has a notably high antagonistic activity as compared with known compounds. Thus, the compound of the present invention is useful as a therapeutic agent for diseases of the cardiovascular system and the central nervous system such as hypertension, heart diseases (for example cardiac hypertrophy, heart failure and myocardial infarction) and cerebral apoplexy. The compound is also useful as a reagent or an agent for studies on the role of angiotensin and its receptors. When a substance of the present invention was given orally to the mice at a dosage of 300 mg/kg and they were observed for one week, none of the mice died in this period. This confirms that the compound of the present invention has no acute toxicity. EXAMPLES The present invention is now further described in the following Examples. Abbreviations used herein are as follows: cyc, cyclic; c-Hex, cyclohexyl; Ph, phenyl; Me, methyl; Et, ethyl; iPr, i-propyl; nPr, n-propyl; nBu, n-butyl; nhex, n-hexyl; Tr, triphenylmethyl. Example 1: Process A, Step (1) Synthesis of 3-(3-methyl-4-nitrophenyl)methyl-N-t-butoxycarbonyl-L-histidine methyl ester (IX-2) Trifluoromethanesulfonic anhydride (10.00 g, 0.0354 mol) and dry methylene chloride (60 ml) were placed into a 500 ml separable flask having its interior atmosphere replaced with well dried nitrogen gas, and cooled to -70°C. Then a solution of 3-methyl-4-nitrobenzyl alcohol (5.34 g, 0.0325 mol) and N,N-diisopropylethylamine (6.2 ml, 0.0356 mol) in dry methylene chloride (40 ml) was added dropwise over a period of 15 minutes, followed by stirring for 30 minutes, after which a solution of N,1-bis-t-butoxycarbonyl-L-histidine methyl ester (XI-2) (10.00 g, 0.0271 mol) in dry methylene chloride (40 ml) was further added dropwise over a period of 20 minutes. Thereafter, the reaction flask was taken out of the cooling bath and the mixture was stirred at room temperature for 6 hours. The reaction mixture during rapid stirring was poured into a 0.2 M phosphate buffer solution (about 400 ml) to separate the methylene chloride layer, and the residue was washed with a 0.2 M phosphate buffer solution (about 400 ml), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain an orange-colored oily material (12.07 g). This crude oily material was purified by silica gel column chromatography (LiChroprep Si60, 300 g, chloroform/methanol = 30/1) to obtain the objective compound (IX-2) (4.45 g; yield: 39.3%) as a light-yellow oily material. There were similarly synthesized the corresponding compounds by using the raw compounds of the formulae (XI) and (X) wherein R 1 was H, Et, iPr, nBu, or nHex, and R 4 , R 6 , R 7 , R 8 , and Y were as shown in Table 1 below. Compound No. R 4 R 6 R 7 R 8 Y X-1 H NO 2 H H OH X-2 Me NO 2 H H OH X-3 H 2-CN-Ph H H OH X-4 H 2-CN-Ph H H Br X-5 Me 2-CN-Ph H H Br X-6 H 2-CN-Ph H H OSO 2 CF 3 X-7 Me NO 2 Me Me OH X-8 Me 2-CN-Ph Me Me Br Example 2: Process A, Step (2) Synthesis of 3-(3-methyl-4-nitrophenyl)methyl-L-histidine dihydrochloride (VIII-2) A 6 N hydrochloric acid solution (54.5 ml) was added to 3-(3-methyl-4-nitrophenyl)methyl-N-t-butoxycarbonyl-L-histidine methyl ester (IX-2) (1.3626 g, 0.00326 mol), and the mixture was refluxed under heating on a 120°C oil bath for 2.5 hours. The resulting solution was cooled and then concentrated to obtain the objective compound (VIII-2) (1.1406 g; yield: 92.9%) as a light-brown oily material. Example 3: Process A, Step (3) Synthesis of (S)-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride (VII-2) A 1 N hydrochloric acid solution (13.7 ml) and a 37% formaldehyde solution (0.74 ml, 0.00907 mol) were added to 3-(3-methyl-4-nitrophenyl)methyl-L-histidine dihydrochloride (VIII-2) (1.1406 g, 0.00302 mol), and the mixture was stirred first at room temperature for half an hour and then on a 120°C oil bath for 1.5 hours. The mixture was then cooled and concentrated to obtain the objective compound (VII-2) (1.1538 g; yield: 98.0%) as yellowish brown crystals (decomposed at 256.5-258°C). Example 4: Process A, Step (4) Synthesis of (S)-1-(3-methyl-4-nitrophenyl)methyl-4,5, 6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester (VI-2) (S)-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride (VII-2) (1.1538g, 0.00296 mol) was suspended in dry methanol (46 ml) and trimethylorthoformate (4.6 ml). Hydrogen chloride was blown into the suspension to saturation under ice cooling and stirring. The reaction solution was then stirred on a 90°C oil bath for 6 hours, cooled, and concentrated. The resulting yellowish brown oily material (0.7456 g) was purified by silica gel column chromatography (Kiesegel 60, 60 g, chloroform/methanol = 15/1) to obtain the objective compound (VI-2) (0.7076 g; yield: 72.3%) as an orange oily material. Similarly to Examples 1-4, there were synthesized the compounds of Table 2. Compound No. R 1 R 4 R 6 R 7 R 8 VI-1 H H NO 2 H H VI-2 H Me NO 2 H H VI-3 Et Me NO 2 H H VI-4 iPr Me NO 2 H H VI-5 nBu Me NO 2 H H VI-6 nHeX Me NO 2 H H VI-7 H H 2-CN-Ph H H VI-8 nBu H 2-CN-Ph H H VI-9 nBu Me 2-CN-Ph H H VI-10 nBu Me NO 2 Me Me VI-11 nBu Me 2-CN-Ph Me Me Example 5: Process A, Step (5) Synthesis of (S)-5-diphenylacetyl-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)-pyridine-6-carboxylic acid methyl ester (V-2) Acetonitrile (16 ml) was added to a mixture of N,N'-dicyclohexylcarbodiimide (DCCI) (2.1080 g, 0.01022 mol), 1-hydroxybenzotriazole (HBTA) (1.3806 g, 0.01022 mol), and diphenylacetic acid (2.1685 g, 0.01022 mol), followed by stirring at room temperature for 20 minutes. A solution of (S)-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester (VI-2) (2.7000 g, 0.00817 mol) in acetonitrile (14 ml) was added to the suspension, and the mixture was stirred at room temperature for 21 hours. An insoluble portion in the reaction mixture was filtered out and washed with acetonitrile, and then the filtrate and washings were joined and concentrated. The residue was dissolved in methylene chloride (40 ml), washed with a 10% sodium carbonate solution and a saturated brine, then dried over sodium sulfate and concentrated to obtain an orange oily material (4.5203 g). This crude oily material was purified by silica gel column chromatography (Kieselgel 60, 270 g, chloroform/methanol = 60/11) to obtain the objective compound (V-2) (2.8250 g; yield: 65.9%) as colorless crystals (mp: 174.5-177°C) Example 6: Process A, Step (6) Synthesis of (S)-5-diphenylacetyl-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-6-carboxylic acid (IV-2) A 1 N sodium hydroxide solution (5.7 ml) was added to a solution of (S)-5-diphenylacetyl-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester (V-2) (2.8250 g, 0.00539 mol) in tetrahydrofuran/methanol (3/1, 17 ml), and the mixture was left at room temperature for 6 hours. The reaction mixture was concentrated, and the residue was weakly acidified by adding a 1 N hydrochloric acid solution (6.0 ml) and then extracted with methylene chloride. The methylene chloride layer was washed with a saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain the objective compound (IV-2) (2.5558 g; yield: 93.0%) as a light-yellow viscous oily material. MS (EI) 492 (M-18). The compounds of Table 3 were synthesized in the similar way to Examples 5 and 6. Compound No. R 1 R 3 R 4 R 6 R 7 R 8 IV-1 H CH(Ph) 2 H NO 2 H H IV-2 H CH(Ph) 2 Me NO 2 H H IV-3 H CH(Ph) (cycC 6 H 11 ) Me NO 2 H H IV-4 Et CH(Ph) 2 Me NO 2 H H IV-5 iPr CH(Ph) 2 Me NO 2 H H IV-6 nBu CH(Ph) 2 Me NO 2 H H IV-7 nHex CH(Ph) 2 Me NO 2 H H IV-8 H CH(Ph) 2 H 2-CN-Ph H H IV-9 nBu CH(Ph) 2 H 2-CN-Ph H H IV-10 nBu CH(Ph) 2 Me 2-CN-Ph H H IV-11 nBu CH(Ph) 2 Me NO 2 Me Me IV-12 nBu CH(Ph) 2 Me 2-CN-Ph Me Me Example 7: Process A, Step (7) Synthesis of (S)-N,N-dimethyl-5-diphenylacetyl-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxamide (III-2) Acetonitrile (40 ml) was added to a mixture of (S)-5-diphenylacetyl-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (IV-2) (2.5558 g, 0.00501 mol), DCCI (1.2916 g, 0.00626 mol) and HBTA (0.8456 g, 0.00626 mol), and the mixture was stirred at room temperature for 20 minutes. Dimethylamine hydrochloride (0.4488 g, 0.00626 mol) was added to the resulting suspension, and the mixture was stirred at room temperature for 18 hours. An insoluble portion in the reaction solution was filtered out and washed with acetonitrile. The filtrate and washings were joined and concentrated. The residue was dissolved in chloroform (40 ml), washed with a 10% sodium carbonate solution and a saturated brine, then dried over sodium sulfate, and concentrated to obtain a light-yellow oily material (4.3025 g). This crude oily material was purified by silica gel column chromatography (Kieselgel 60, 220 g, chloroform/methanol = 60/1) to obtain the objective compound (III-2) (2.3636 g; yield: 87.8%) as a light-yellow viscous oily material. MS (EI): 538 (M+1). There were similarly synthesized the compounds of Table 4. Compound No. R 1 R 2' R 3 R 4 R 6 R 7 R 8 III-1 H NMe 2 CH(Ph) 2 H NO 2 H H III-2 H NMe 2 CH(Ph) 2 Me NO 2 H H III-3 H NEt 2 CH(Ph) 2 Me NO 2 H H III-4 H NMe 2 CH(Ph) (cyc C 6 H 11 ) Me NO 2 H H III-5 H cycNC 4 H 8 CH(Ph) 2 Me NO 2 H H III-6 H cycNC 5 H 10 CH(Ph) 2 Me NO 2 H H III-7 H cycNC 4 H 8 O CH(Ph) 2 Me NO 2 H H III-8 H NH 2 CH(Ph) 2 H NO 2 H H III-9 H NHMe CH(Ph) 2 H NO 2 H H III-10 Et NMe 2 CH(Ph) 2 Me NO 2 H H III-11 iPr NMe 2 CH(Ph) 2 Me NO 2 H H III-12 nBu NMe 2 CH(Ph) 2 Me NO 2 H H III-13 nHeX NMe 2 CH(Ph) 2 Me NO 2 H H III-14 H NMe 2 CH(Ph) 2 H 2-CN-Ph H H III-15 nBu NMe 2 CH(Ph) 2 H 2-CN-Ph H H III-16 nBu NMe 2 CH(Ph) 2 Me 2-CN-Ph H H III-17 nBu NMe 2 CH(Ph) 2 Me NO 2 Me Me III-18 nBu NMe 2 CH(Ph) 2 Me 2-CN-Ph Me Me Example 8: Process A, Step (8) Synthesis of (S)-1-(4-amino-3-methylphenyl)methyl-N,N-dimethyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxamide (II-2) (S)-N,N-dimethyl-5-diphenylacetyl-1-(3-methyl-4-nitrophenyl)methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-6-carboxamide (III-2) (2.3636 g, 0.00440 mol) was dissolved in a mixture of 28 ml of ethyl acetate and 5 ml of methanol, followed by addition of tin chloride dihydrate (4.9580 g, 0.0220 mol) and agitation of the solution on an 80°C oil bath in a stream of nitrogen for 30 minutes. The reaction mixture was cooled, neutralized by adding a 5% sodium carbonate solution, and concentrated. The residue was extracted with chloroform. The chloroform layer was washed with water, dried over sodium sulfate, and then concentrated to obtain a light-yellow foamy material (2.2368 g). This material was purified by silica gel column chromatography (Kieselgel 60, 120 g, chloroform /methanol = 50/1) to obtain the objective compound (II-2) (2.0077 g; yield: 90.0%) as a white foamy material. MS (EI): 508 (M+1). There were similarly synthesized the compounds of Table 5. Compound No. R 1 R 2' R 3 R 4 R 7 R 8 II-1 H NMe 2 CH(Ph) 2 H H H II-2 H NMe 2 CH(Ph) 2 Me H H II-3 H NEt 2 CH(Ph) 2 Me H H II-4 H NMe 2 CH(Ph) (cyc C 6 H 11 ) Me H H II-5 H cycNC 4 H 8 CH(Ph) 2 Me H H II-6 H cycNC 5 H 10 CH(Ph) 2 Me H H II-7 H cycNC 4 H 8 O CH(Ph) 2 Me H H II-8 H NH 2 CH(Ph) 2 H H H II-9 H NHMe CH(Ph) 2 H H H II-10 Et NMe 2 CH(Ph) 2 Me H H II-11 iPr NMe 2 CH(Ph) 2 Me H H II-12 nBu NMe 2 CH(Ph) 2 Me H H II-13 nHex NMe 2 CH(Ph) 2 Me H H II-14 nBu NMe 2 CH(Ph) 2 Me Me Me Example 9: Process A, Step (9) Synthesis of (S)-1-(4-(2-carboxybenzoylamino)-3-methylphenyl)methyl-N,N-dimethyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxamide (I-2) A solution of phthalic acid (0.7223 g, 0.00435 mol) in ethyl acetate (10 ml) was added to a solution of (S)-1-(4-amino-3-methylphenyl)methyl-N,N-dimethyl-5-diphenylacetyl4,5,6,7-tetrahydro-1H-imidazo-[4,5-c]pyridine-6-carboxamide (II-2) (2.0077 g, 0.00396 mol) in ethyl acetate (30 ml) with stirring at room temperature. The mixture was stirred at room temperature for 23 hours, followed by filtration of the reaction mixture. The resulting white solid was washed with ethyl acetate (about 20 ml) and dried to obtain the objective compound (I-2, Compound No. 2) (2.4107 g; yield: 93.0%). MS 637 (EI): (M-18). There were similarly synthesized the compounds of Table 6. The results of elementary analysis of the compounds of Table 6 are shown in Table 7. Compound No. Elementary analysis Calcd. for (C, H, N) (%) Found (C, H, N) (%) I-1 C 38 H 35 N 5 O 5 71.12, 5.50, 10.91 71.01, 5.57, 10.90 I-2 C 39 H 37 N 5 O 5 71.43, 5.69, 10.68 71.34, 5.73, 10.70 I-3 C 41 H 41 N 5 O 5 72.02, 6.04, 10.24 71.93, 6.10, 10.22 I-4 C 39 H 43 N 5 O 5 70.78, 6.55, 10.58 70.70, 6.62, 10.55 I-5 C 41 H 39 N 5 O 5 72.23, 5.76, 10.27 72.11, 5.89, 10.25 I-6 C 42 H 41 N 5 O 5 72.50, 5.94, 10.06 72.39, 6.01, 10.04 I-7 C 41 H 39 N 5 O 6 70.57, 5.63, 10.04 70.45, 5.71, 10.06 I-8 C 36 H 31 N 5 O 5 70.46, 5.09, 11.41 70.33, 5.20, 11.39 I-9 C 37 H 33 N 5 O 5 70.80, 5.30, 11.16 70.70, 5.44, 11.15 I-10 C 41 H 41 N 5 O 5 72.02, 6.04, 10.24 71.90, 6.15, 10.26 I-11 C 42 H 43 N 5 O 5 72.29, 6.21, 10.03 72.15, 6.35, 10.06 I-12 C 43 H 45 N 5 O 5 72.55, 6.37, 9.84 72.44, 6.48, 9.88 I-13 C 45 H 49 N 5 O 5 73.05, 6.67, 9.46 72.94, 6.78, 9.45 I-14 C 45 H 49 N 5 O 5 73.05, 6.67, 9.46 72.98, 6.77, 9.47 Example 10: Process A, Step (10) Synthesis of (S)-1-((2'-carboxybiphenyl-4-yl)methyl)-N,N-dimethyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxamide (I-15) Ten ml of ethyl alcohol and 20 ml of a 1 N aqueous sodium hydroxide solution were added to (S)-1-((2'-cyanobiphenyl-4-yl)methyl)-N,N-dimethyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo-[4,5-c]pyridine-6-carboxamide (III-14) (1.9550 g, 0.00337 mol), and the mixture was refluxed under heating for 3 hours, then neutralized with a 6 N hydrochloric acid solution, and concentrated. The residue was extracted with chloroform, washed with water, dried over sodium sulfate, and concentrated to obtain a light-yellow foamy material (2.1179 g). This material was purified by silica gel column chromatography (Kieselgel 60, 110 g, chloroform/methanol = 50/1) to obtain the objective product (I-15; Compound No. 15) (1.8756 g; yield: 92.9%) as a white foamy material. MS (EI): 580 (M-18). The compounds of Table 8, including compounds wherein R is 2-(1H-tetrazol-5-yl)phenyl, were synthesized in the similar way. The results of elementary analysis of the compounds of Table 8 are shown in Table 9. Example 11: Process B, Step (a) Synthesis of (S)-2-triphenylmethylamino-3-(1-triphenylmethylimidazol-5-yl)propanoic acid methyl ester (XXII) Triethylamine (145 ml, 1.038 mol) was added to a solution of the compound (XXIII) (50.25 g, 0.208 mol) and , TrCl (138.90 g, 0.498 mol) in CH 2 Cl 2 (500 ml) dropwise with stirring under ice cooling for 30 minutes, followed by 6-hour stirring at room temperature. The reaction mixture was poured into water and extracted with CH 2 Cl 2 . The organic layer was washed with a saturated NaCl aqueous solution, dried over Na 2 SO 4 , and concentrated to obtain a crude product (168.87 g) as a yellow oily material. This crude product was purified by silica gel column chromatography (hexane/acetone = 3/1) to obtain the objective compound (XXII) (119.934 g; yield: 88.4%) as a white foamy material. 1 H-NMR (CDCl 3 ) δ: 2.71 (d, 1H, J=10.5 Hz, N H ), 2.78 (dd, 1H, J=6.9, 13.8 Hz), 2.96 (dd, 1H, J=6.9, 13.8 Hz), 3.05 (s, 3H), 3.66 (dt, 1H, J=6.9, 10.5 Hz), 6.62 (s, 1H), 7.11-7.15 (m, 9H), 7.18-7.21 (m, 6H), 7.26-7.32 (m, 9H), 7.36 (s, 1H), 7.43 (d-like, 6H, J=7.3 Hz). IR (ν max , KBr): 3480, 1748, 1509, 1455, 1163, 748, 705 cm -1 . Example 12: Process B, Step (b) Synthesis of (S)-2-triphenylmethylamino-3-(1-triphenylmethylimidazol-5-yl)propanol (XXI) The compound (XXII) (58.917 g, 0.0901 mol) was added to a suspension of LiAlH 4 (6.839 g, 0.180 mol) in dry Et 2 O (590 ml) over a period of 2.5 hours. The mixture was stirred under ice cooling for one hour, and then Na 2 SO 4 ·10H 2 O was added to the resulting solution to dispose of the excess LiAlH 4 , followed by filtration with Celite 545. The filtrate was concentrated and the residue was diluted with CHCl 3 , washed with a saturated NH 4 Cl aqueous solution and a saturated NaCl aqueous solution, then dried over Na 2 SO 4 , and concentrated to obtain the objective compound (56.390 g; yield: 100%) as a white foamy material. 1 H-NMR (CDCl 3 ) δ: 1.90 (b, 1H, N H ), 1.95 (dd, 1H, J=6.4, 14.7 Hz), 2.38 (dd, 1H, J=3.2, 14.7 Hz), 2.91 (b, 1H), 2.99 (dd, 1H, J=6.4, 11.5 Hz), 3.47 (dd, 1H, J=3.2, 11.5 Hz), 4.95 (b, 1H, OH), 6.29 (s, 1H), 7.09-7.20 (m, 15H), 7.26-7.33 (m, 10H), 7.48-7.49 (m, 6H). IR (ν max , KBr): 3480, 1550, 1455, 1036, 746, 702 cm -1 . Example 13: Process B, Step (c) Synthesis of (S)-1-t-butyldimethylsilyloxy-2-triphenyl-methylamino-3-(1-triphenylmethylimidazol-5-yl)propane (XX) Imidazole (12.269 g, 0.180 mol) and tertbutyldimethylsilyl chloride (TBDMSCl) (20.37 g, 0.135 mol) were added to a solution of the compound (XXI) (56.390 g, 0.0901 mol) in dry DMF (560 ml) under ice cooling, and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was poured into water, extracted with Et 2 O, washed with water and a saturated NaCl aqueous solution, then dried over Na 2 SO 4 , and concentrated to obtain a light-yellow foamy material (67.602 g). This crude product was purified by silica gel column chromatography (hexane/acetone = 5/1) to obtain the objective compound (XX) (58.770 g; yield: 88.1%) as a whité foamy material. 1 H-NMR (CDCl 3 ) δ: -0.13 (s, 6H), 0.80 (s, 9H), 1.60 (b, 1H, N H ), 2.19 (dd, 1H, J=7.6, 14.2 Hz), 2.57 (dd, 1H, J=4.1, 14.2 Hz), 2.73 (b, 1H), 2.89 (dd, 1H, J=6.0, 9.6 Hz), 3.27 (dd, 1H, J=4.1, 9.6 Hz), 5.35 (s, 2H), 6.38 (s, 1H), 7.12-7.35 (m, 25H), 7.56 (d-like, 6H, J=7.3 Hz). IR (ν max , KBr): 3100, 2990, 2970, 2925, 2890, 1508, 1480, 1455, 1253, 1132, 1090, 1072, 1035, 900, 830, 770, 742, 700, 658, 636 cm -1 . Example 14: Process B, Step (d) Synthesis of (S)-1-t-butyldimethylsilyloxy-2-triphenylmethylamino-3-(2-n-butyl-1-triphenylmethylimidazol-5-yl) propane (XIX-3) A 1.5 N nBuLi/hexane mixed solution (61.0 ml, 0.0914 mol) was added dropwise to a solution of the compound (XX) (22.557 g, 0.0305 mol) in dry Et 2 O (340 ml) over a period of 15 minutes by using an injector. Three minutes thereafter, nBuI (5.2 ml, 0.0457 mol) and HMPA (38 ml) were added dropwise with an injector under the same conditions. After 20-minute stirring, the mixture was heated to room temperature and further stirred for 4 hours. The reaction mixture was poured into water and extracted with EtOAc. The organic layer was washed with a saturated NaCl solution, then dried over Na 2 SO 4 , and concentrated to obtain a yellow oily material (25.830 g; yield: 100% up). This material was purified by silica gel column chromatography (hexane /acetone = 20/1) to obtain the objective compound (XIX-3) (10.710 g; yield: 44.1%) as a light-yellow foamy material. 1 H-NMR (CD 2 Cl 2 ) δ: -0.136, -0.144 (each s, each 3H), 0.58 (t, 3H, J=7.3 Hz), 0.77 (s, 9H), 0.89 (sext, 2H, J=7.3 Hz), 1.01 (m, 1H), 1.12 (m, 1H), 1.78 (m, 2H), 1.98 (dd, 1H, J=6.7, 14.0 Hz), 2.43 (dd, 1H, J=4.8, 14.0 Hz), 2.57 (b, 1H, C H ), 3.06 (dd, 1H, J=6.9, 9.6 Hz), 3.10 (b, 1H, N H ), 3.28 (dd, 1H, J=4.4, 9.6 Hz), 6.19 (s, 1H), 7.06-7.54 (m, 30H). IR (ν max , KBr): 3500, 3000, 2975, 2905, 1510, 1459, 1408, 1260, 1160, 1093, 1075, 1038, 834, 775, 746, 702, 640 cm -1 . There were similarly synthesized the compounds of Table 10. Compound No. R 1 Elementary analysis Calcd. for (C, H, N) (%) Found (C, H, N) (%) MS(EI) XIX-1 nPr C 53 H 59 N 3 OSi 81.39, 7.60, 5.37 81.50, 7.48, 5.30 782(M + ) XIX-2 iPr C 53 H 59 N 3 OSi 81.39, 7.60, 5.37 81.47, 7.52, 5.29 782(M + ) XIX-3 nBu C 54 H 61 N 3 OSi 81.46, 7.72, 5.28 81.61, 7.69, 5.19 796(M + ) XIX-4 nHex C 56 H 65 N 3 OSi 82.61, 8.05, 5.16 82.76, 7.98, 5.09 814(M + ) Example 15: Process B, Step (e) Synthesis of (S)-2-amino-3-(2-n-butyl-1H-imidazol-5-yl)propanol (XVIII-3) and (S)-2-n-butyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-methanol hydrochloride (XVII-3) A 1 N HCl aqueous solution (140 ml) and a 37% HCHO aqueous solution (3.6 ml) were added to the compound (XIX-3) (11.745 g, 0.0148 mol) and the mixture was stirred first at room temperature for 40 minutes and then in a 120°C oil bath for 4 hours. The reaction mixture was cooled and the insoluble portion was filtered out, followed by washing with water. The aqueous layer was washed with Et 2 O, then concentrated, and dried to obtain the objective compound (XVII-3) (4.0370 g; yield: 97.0%) as a yellow solid. 1 H-NMR (D 2 O) δ: 0.95 (t, 3H, J=7.3 Hz), 1.40 (sext, 2H, J=7.3 Hz), 1.79 (quint, 2H, J=7.3 Hz), 3.02 (t, 2H, J=7.3 Hz), 3.12 (d-like, 1H, J=4.6 Hz), 3.16 (bs, 1H), 3.85-3.90 (m, 2H), 4.08 (d-like, 1H, J=9.2 Hz), 4.48 (d, 1H, J=15.4 Hz), 4.52 (d, 1H, J=15.4 Hz). IR(ν max ,KBr): 3410, 2950, 1675, 1620, 1560, 1430, 1065 cm -1 . The compounds shown in Table 11 were similarly synthesized. Compound No. R 1 MS (EI) XVII-1 nPr 195 (M-2HCl) XVII-2 nHex 195 (M-2HCl) XVII-3 nBu 209 (M-2HCl) XVII-4 nHex 237 (M-2HCl) By using the compound (XIX-3) (1.7750 g, 0.00223 mol) and an 1 N HCl aqueous solution (18 ml), the above reaction procedure was followed without adding the 37% HCHO aqueous solution to obtain the objective compound (XVIII-3) (0.7003 g; yield: 99.6%) as a yellow viscous material. 1 H-NMR (D 2 O) δ: 0.96 (t, 3H, J=7.3 Hz), 1.39 (sext, 2H, J=7.3 Hz), 1.80 (quint, 2H, J=7.3 Hz), 3.00 (t, 2H, J=7.3 Hz), 2.8-3.3 (m, 3H), 3.7-4.3 (m, 2H), 6.05 (bs, 1H). MASS (EI): 197 (M-2HCl). There were similarly synthesized the compounds shown in Table 12. Compound No. R 1 MASS (EI) XVIII-1 nPr 183 (M-2HCl) XVIII-2 iPr 183 (M-2HCl) XVIII-3 nBu 197 (M-2HCl) XVIII-4 nHex 225 (M-2HCl) Example 16: Process B, Step (f) Synthesis of (S)-2-n-butyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-methanol (XVI-4) Diphenylacetic acid (14.6617 g, 0.069 mol), N,N'-dicyclohexylcarbodiimide (DCCI) (14.2528 g, 0.069 mol), and l-hydroxybenzotriazole (HBTA) (9.3345 g, 0.069 mol) were dissolved in dry THF (61 ml) and stirred at room temperature for 20 minutes. A solution of the compound (XVII-3) (6.0920 g, 0.0216 mol) in dry THF (30 ml) and dry triethylamine (TEA) (6.0 ml, 0.043 mol) were added to this solution, followed by stirring at room temperature for 14 hours. The insoluble portion was filtered out and washed with THF. The filtrate and washings were joined and concentrated to obtain a crude oily material (11.0015 g). This material was dissolved in a 1/1 mixture (100 ml) of THF and MeOH, after addition of a 1 N HCl aqueous solution (25 ml), left as it was for 8 hours. Then, to the mixture added a 1/1 mixture (100 ml) of THF and MeOH and a 1 N NaOH solution (50 ml), and the mixture was left as it was for 10 hours. The reaction mixture was concentrated. White crystals were precipitated by addition of H 2 O (50 ml). These crystals were washed with water and then vacuum dried to give the compound (XVI-4) (2.1518 g; m.p. 199-202°C; yield: 24.7%). 1 H-NMR (CDCl 3 ) δ: 0.90, 0.91 (each t, 3H, J=7.3 Hz), 1.30-1.38 (m, 2H), 1.40-1.90 (b, 1H, OH), 1.55-1.70 (m, 2H), 2.55-2.62 (m, 2H), 2.33, 2.81 (s-like, dd, 2H), 3.43-3.58 (m, 2H), 3.86-4.08 (each d, 1H, J=16.7, 15.4 Hz), 4.47, 4.70 (bs, d, 2H, J=16.7 Hz), 5.28, 5.32, 5.51 (d, s, s, 2H, J=16.7 Hz), 7.10-7.60 (m, 10H), 8.80 (b, 1H, NH). IR (ν max ,KBr): 3425, 2970, 2930, 2860, 1620, 1450, 1420, 740, 695 cm -1 . The compounds shown in Table 13 were similarly synthesized. Example 17: Process B, Step (g) Synthesis of (S)-2-n-butyl-1-[(4-methoxycarbonylphenyl)methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-methanol (XV-8) Methyl 4-(bromomethyl)benzoate (0.0334 g, 0.00015 mol) and K 2 CO 3 (0.0201 g, 0.00015 mol) were added to a solution of the compound (XVI-4) (0.0491 g, 0.00012 mol) in dry DMF (0.49 ml), and the mixture was stirred vigorously at room temperature for 24 hours. The reaction mixture was poured into water, extracted with EtOAc, washed with water, then dried over Na 2 SO 4 , and concentrated to obtain a light-yellow oily material (0.0656 g). This crude oily product was purified by silica gel column chromatography (hexane/ acetone = 1/2) to obtain the objective compound (XV-8) (0.0211 g), its 3-position isomer (0.0262 g), and a mixture of them (0.0035 g), each as a white foamy material (yield: 75.7%). The structures of the two compounds were determined by an NOE difference spectrum. 1 H-NMR (CDCl 3 ) δ: 0.86, 0.87 (each, t, 3H, J=7.3 Hz), 1.28-1.36 (m, 2H), 1.58-1.65 (m, 3H, CH 3 CH 2 C H 2 CH 2 -, CH 2 O H ), 1.99-2.63 (m, 2H), 2.52-2.63 (m, 2H), 3.31-3.57 (m, 2H, C H 2 OH), 3.92, 3.93 (each, s, 3H), 3.90, 4.13, 4.76, 5.42 (each, d, 2H, J=15.4 Hz), 4.40-4.47, 5.26-5.30 (each, m, 1H), 4.94, 5.02 (each, s, 2H), 5.35, 5.43 (each s, 1H), 6.91-6.99 (m, 2H), 7.17-7.32 (m, 10H), 7.98-8.01 (m, 2H). IR (ν max ,KBr): 3460, 1725, 1640, 1453, 1430, 1415, 1280, 1110, 743, 700 cm -1 . Example 18: Process B, Step (g) Synthesis of (S)-2-n-butyl-1-[(2'-cyanobiphenyl-4-yl) methyl] -5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo [4,5-c]pyridine-6-methanol (XV-10) 4'-(bromomethyl)-2-cyanobiphenyl (2.3655 g, 0.0869 mol) and K 2 CO 3 (1.9222 g, 0.0139 mol) were added to a solution of the compound (XVI-4) (2.8060 g, 0.00695 mol) in dry DMF (28 ml), and the mixture was stirred vigorously at room temperature for 23 hours. The reaction mixture was poured into water, extracted with EtOAc, washed with water, dried over Na 2 SO 4 , and concentrated to obtained a light-yellow foamy material (4.5301 g). This material was purified by silica gel column chromatography to obtain the compound (XV-10) (0.9288 g), its 3-position isomer (1.4733 g), and a mixture of them (0.0207 g) (yield: 58.6%). The structures of the two compounds were determined by an NOE difference spectrum. 1 H-NMR (CDCl 3 ) δ: 0.89, 0.90 (each t, 3H, J=7.3 Hz), 1.36 (sext, 2H, J=7.3 Hz), 1.64-1.78 (m, 2H), 1.88 (bs, 1H, OH), 2.14, 2.72 (each dd, 1H, J=6.0, 15.6 Hz), 2.21, 2.51 (each d, 1H, J=15.6 Hz), 2.60-2.67 (m, 2H), 3.35-3.62 (m, 2H, C H 2 OH), 3.96, 4.93 (each d, 1H, J=17.0 Hz), 4.12, 4.78 (each d, 1H, J=15.6 Hz), 4.47-4.51, 5.35-5.40 (each m, 1H), 5.06-5.13 (m, 2H), 5.36, 5.42 (each s, 1H), 6.93-7.10 (m, 2H), 7.15-7.39 (m, 10H), 7.40-7.58 (m, 4H), 7.60-7.82 (m, 2H). IR (ν max , KBr): 3425, 2960, 2925, 2860, 1637, 1500, 1480, 1450, 1410, 1375, 760, 740, 700 cm -1 . There were similarly synthesized the compounds shown in Table 14. Example 19: Process B, Step (h) Synthesis of (S) -2-n-butyl-1-[(4-methoxycarbonylphenyl)methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (XIV-8) CrO 3 (0.33 g) was dissolved in H 2 O (0.62 ml), and concentrated H 2 SO 4 was slowly added dropwise thereto. The, resultantly produced salt was dissolved in H 2 O (0.1 ml) to prepare an oxidizing reagent. Meanwhile, the compound (XV-8) (0.2916 g) was dissolved in acetone (4.4 ml), and the previously prepared oxidizing reagent was added dropwise thereto at room temperature until the orangish red color did not fade away. After 30-minute stirring, iPrOH was added to the reaction mixture until it assumed a green color, and then the mixture was concentrated. The resulting crude product was purified by silica gel column chromatography (CHCl 3 /MeOH = 8/1) to obtain the objective compound (XIV-8) (0.1883 g; m.p. 177-180°C ; yield: 63.0%). 1 H-NMR (CDCl 3 ) δ: 0.79, 0.83 (each t, 3H, J=7.3 Hz), 1.18-1.28 (m, 2H), 1.40-1.55 (m, 2H), 1.77, 2.99, 3.24-3.44 (m, d, m, 2H, J=14.7 Hz), 2.45-2.70 (m, 2H), 3.89, 3.92 (each s, 3H), 4.28, 4.57, 4.69, 5.07 (each d, 2H, J=14.7 Hz), 5.17-5.27 (m, 2H), 5.51, 5.55 (each s, 1H), 5.51-5.55, 5.70 (d, 1H, J=5.5 Hz), 7.09-7.45 (m, 12H), 7.90-8.10 (m, 2H). IR (ν max ,KBr): 3470, 2980, 1726, 1640, 1615, 1506, 1455, 1435, 1417, 1283, 1190, 1112, 750, 700 cm -1 . Example 20: Process B, Step (h) Synthesis of (S)-2-n-butyl-1-[(2'-cyanobiphenyl-4-yl) methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo [4,5-c]pyridine-6-carboxylic acid (XIV-10) The oxidizing reagent (0.9 ml) as prepared in Example 19 was added dropwise to a solution of the compound (XV-10) (0.6249 g, 0.00105 mol) in acetone (9.4 ml) at room temperature. After 30-minute stirring, iPrOH was added to the reaction mixture until it assumed a green color, and then the mixture was concentrated. The resulting crude product was purified by silica gel column chromatography (CHCl 3 /MeOH = 6/1) to obtain the compound (XIV-10) (0.3619 g; yield: 56.6%) as a white foamy material. 1 H-NMR (CDCl 3 ) δ: 0.75-1.06 (m, 3H), 1.15-1.40 (m, 2H), 1.44-1.70 (m, 2H), 2.46-2.64 (m, 2H), 2.69, 2.93 (each dd, 1H, J=6.0, 15.6 Hz), 3.08, 3.31 (each d, 1H, J=15.6 Hz), 4.27, 4.67 (each d, 1H, J=15.6 Hz), 4.58, 4.99 (each d, 1H, J=15.6 Hz), 4.94-5.25 (m, 2H), 5.32, 5.43 (each s, 1H), 4.83, 5.68 (each d, 1H, J=6.0 Hz), 7.02-7.85 (m, 18H). IR (ν max , KBr) ν max : 3425, 2960, 1620, 1500, 1408, 758, 742, 700, 630, 560 cm -1 . There were similarly synthesized the compounds shown in Table 15. Example 21: Process B, Step (i) Synthesis of 4-[[(S)-2-butyl-1-[(4-methoxycarbonylphenyl)methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl]carbonyl]morpholine (XIII-8) The compound (XIV-8) (0.1315 g, 0.00023 mol), DCCI (0.0624 g, 0.0003 mol), HBTA (0.0377 g, 0.00028 mol), and morpholine (0.024 ml, 0.00028 mol) were dissolved in dry THF (2.0 ml) and stirred at room temperature for 19 hours. The insoluble portion was filtered out and washed with THF. The filtrate and washings were joined and concentrated to obtain a crude oily product (0.3010 g). This crude product was purified by silica gel column chromatography (CHCl 3 /MeOH = 60/1) to obtain a white foamy material (0.1204 g). This material was again purified by using a preparative TLC plate (0.5 mm thick, 20 cm x 20 cm; developing solvent: hexane/acetone = 2/3) to obtain the objective compound (XIII-8) (0.0911 g; yield: 61.7%). 1 H-NMR (CDCl 3 ) δ: 0.84 (t, 3H, J=7.3 Hz), 1.28 (sext, 2H, J=7.3 Hz), 1.58 (quint, 2H, J=7.3 Hz), 2.49 (t, 2H, J=7.3 Hz), 2.70 (dd, 1H, J=6.0, 15.1 Hz), 2.80 (d, 1H, J=15.1 Hz), 3.25-3.70 (b, 8H), 3.92 (s, 3H), 4.26 (d, 1H, J=15.1 Hz), 4.90 (d, 1H, J=15.1 Hz), 5.02, 5.07 (each d, each 1H, J=17.4 Hz), 5.35 (s, 1H), 5.96 (d, 1H, J=6.0 Hz), 7.09 (d, 2H, J=8.3 Hz), 7.17-7.35 (m, 10H), 8.02 (d, 2H, J=8.3 Hz). IR (ν max , KBr): 3460, 1725, 1645, 1455, 1433, 1415, 1280, 1230, 1113, 750, 700 cm -1 . Example 22: Process B, Step (i) Synthesis of 4-[[(S)-2-butyl-1-[(2'-cyanobiphenyl-4-yl) methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo-[4,5-c]pyridin-6-yl]carbonyl]morpholine (XIII-10) The compound (XIV-10) (0.3301 g, 0.000542 mol), DCCI (0.1455 g, 0.000705 mol), HBTA (0.0953 g, 0.000705 mol), and morpholine (0.06 ml, 0.000705 mol) were dissolved in dry THF (5.0 ml) and stirred at room temperature for 48 hours. The insoluble portion was filtered out and washed with THF. The filtrate and washings were joined and concentrated to obtain a crude product (0.5500 g). This crude product was purified by silica gel column chromatography (hexane/acetone = 2/3) to obtain the objective compound (XIII-10) (0.1764 g; yield: 48.0%) as a white foamy material. 1 H-NMR (CDCl 3 ) δ: 0.87 (t, 3H, J=7.3 Hz), 1.32 (sext, 2H, J=7.3 Hz), 1.64 (quint, 2H, J=7.3 Hz), 2.55 (t, 2H, J=7.3 Hz), 2.77 (dd, 1H, J=6.0, 15.1 Hz), 2.86 (d, 1H, J=15.1 Hz), 3.20-3.80 (b, 8H), 4.29 (d, 1H, J=15.6 Hz), 4.90 (d, 1H, J=15.6 Hz), 5.04 (d, 1H, J=17.0 Hz), 5.09 (d, 1H, J=17.0 Hz), 5.37 (s, 1H), 5.99 (d, 1H, J=6.0 Hz), 7.20-7.85 (m, 18H). IR (ν max , KBr): 3430, 1640, 1450, 1408, 1228, 1113, 760, 700 cm -1 . MS (EI): 678 (M + ): The compounds shown in Tables 16 and 17 were similarly synthesized. Example 23: Process B, Step (j) Synthesis of 4-[[(S)-2-n-butyl-1-[(4-carboxyphenyl)-methyl]5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl]carbonyl]morpholine (I-29) The compound (XIII-8) (0.0761 g, 0.00012 mol) was dissolved in a 1/1 mixture of THF and MeOH (1.52 ml), followed by addition of a 1 N NaOH aqueous solution (0.38 ml), and the mixture was left as it was for 16.5 hours. The reaction mixture was concentrated, and a 1 N HCl aqueous solution (0.43 ml) (pH 4) was added thereto to cause acid precipitation. The resulting oily material was dissolved in CHCl 3 , washed with water, dried over Na 2 SO 4 , and concentrated to obtain the objective compound (I-29) (0.0735 g; yield: 98.8%) as a white foamy material. 1 H-NMR (CDCl 3 +D 2 O) δ: 0.84 (t, 3H, J=7.3 Hz), 1.27 (sext, 2H, J=7.3 Hz), 1.57 (quint, 2H, J=7.3 Hz), 2.55 (t, 2H, J= 7.3 Hz), 2.70 (dd, 1H, J=6.0, 15.6 Hz), 2.86 (d, 1H, J=15.6 Hz), 3.30-3.65 (b, 8H), 4.24 (d, 1H, J=15.6 Hz), 5.06 (d, 1H, J=17.4 Hz), 5.10 (d, 1H, J=17.4 Hz), 5.12 (d, 1H, J=15.6 Hz), 5.43 (s, 1H), 5.97 (d, 1H, J=6.0 Hz), 7.12 (d, 2H, J= 8.3 Hz), 7.17-7.33 (m, 10H), 8.09 (d, 2H, J=8.3 Hz). IR (ν max , KBr): 3460, 1715, 1646, 1453, 1412, 1270, 1230, 1115, 745, 700 cm -1 . Example 24: Process B, Step (k) Synthesis of 4-[[(S)-l-[(4-amino-3-methylphenyl)-methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl]carbonyl]morpholine (I'-1) The compound (XIII-3) (1.0079 g, 0.00174 mol) was dissolved in 10 ml of ethyl acetate, then tin chloride dihydrate (1.9632 g, 0.00870 mol) was added thereto. The mixture was stirred on an 80°C oil bath in a stream of nitrogen for 30 minutes. The reaction mixture was cooled, neutralized with a 5% sodium carbonate aqueous solution, and concentrated. The residue was extracted with chloroform. The chloroform layer was washed with water, dried over anhydrous sodium sulfate, and concentrated to obtain a light-yellow foamy material. This substance was purified by silica gel column chromatography (chloroform/methanol = 70/1) to obtain the objective compound (I'-1) (0.8781 g; yield: 91.9%) as a white foamy material. 1 H-NMR (CDCl 3 ) δ: 2.10 (s, 3H), 2.74 (dd, 1H, J=6.4, 15.6 Hz), 3.20 (d, 1H, J=15.6 Hz), 3.2-3.8 (b, 10H), 4.29 (d, 1H, J=14.8 Hz), 4.75 (d, 1H, J=14.8 Hz), 4.80 (d, 1H, J=15.0 Hz), 4.90 (d, 1H, J=15.0 Hz), 5.35 (s, 1H), 6.01 (d, 1H, J=6.4 Hz), 6.62 (d, 1H, J=8.3 Hz), 6.80 (d, 1H, J=8.3 Hz), 6.81 (s, 1H), 7.1-7.4 (m, 11H). MS (EI): 550 (M + ): Elementary analysis Calcd. for C 33 H 35 N 5 O 3 (%): C, 72.11; H, 6.42; N, 12.74. Found: C, 72.21; H, 6.35; N, 12.66. Example 25: Process B, Step (1) Synthesis of 4-[[(S)-2-n-butyl-5-diphenylacetyl-1-[(2'-1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl]carbonyl)-morpholine (I-31) Trimethyltin azide (0.0998 g, 0.000485 mol) was added to a solution of the compound (XIII-10) (0.1644 g, 0.000243 mol) in o-xylene (2.5 ml), and the mixture was stirred on a 120°C oil bath in a nitrogen stream for 90 hours. The reaction mixture was cooled. The insoluble portion was filtered out, washed with hot toluene, and vacuum dried. The resulting light-yellow solid was dissolved in MeOH (1.8 ml), and a 1 N HCl aqueous solution (0.9 ml) was added thereto, and the mixture was stirred at room temperature for 15 minutes. The reaction mixture was adjusted to pH 4 by adding a 1 N NaOH aqueous solution and then concentrated, and the residue was extracted with CHCl 3 . The chloroform layer was washed with water, dried over anhydrous sodium sulfate, and concentrated to obtain a light-yellow foamy material. This material was purified by silica gel column chromatography (chloroform/methanol = 10/1) to obtain the objective compound (I-31) (0.1281 g; yield: 73.3%) as a white foamy material. 1 H-NMR (CDCl 3 +D 2 O) δ: 0.92 (t, 3H, J=7.3 Hz), 1.35 (sext, 2H, J=7.3 Hz), 1.52-1.73 (m, 2H), 1.38-2.75 (m, 4H), 3.20-3.67 (m, 8H), 3.76 (d, 1H, J=15.1 Hz), 4.54 (d, 1H, J=15.1 Hz), 4.92 (d, 1H, J=16.5 Hz), 5.05 (d, 1H, J=16.5 Hz), 5.14 (s, 1H), 5.81 (bs, 1H), 6.92-7.96 (m, 18H). IR (ν max , KBr): 3425, 1635, 1445, 1405, 1225, 1108, 748, 700 cm -1 . MS (FAB) : 721 (M + ). Example 26: Process B, Step (m) Synthesis of 4-[[(S)-5-diphenylacetyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl]carbonyl]morpholine (I-24) A 12% HCl aqueous solution (5.5 ml) was added to a solution of the compound (XIII-5) (1.1103 g, 0.00122 mol) in THF (11 ml), and the mixture was stirred at room temperature for 4 hours. The reaction solution was neutralized by adding a 10% NaOH aqueous solution and concentrated. The residue was dissolved in a 1 N NaOH aqueous solution and the insoluble portion was filtered out. The filtrate was adjusted to pH 4 by adding a 1 N HCl aqueous solution and extracted with CHCl 3 . The chloroform layer was washed with water, dried over anhydrous sodium sulfate, and concentrated to obtain a light-yellow foamy material. This material was purified by silica gel column chromatography (chloroform/methanol = 10/1) to obtain the objective compound (I-24) (0.7413 g; yield: 91.1%) as a white foamy material. 1 H-NMR (D 2 O+NaOD) δ: 2.71 (dd, 1H, J=7.2 Hz), 2.80 (d, 1H, J=15.1 Hz), 3.2-3.8 (b, 8H), 4.27 (d, 1H, J=15.1 Hz), 5.85 (b, 1H), 6.8-8.1 (m, 19H). MASS (FAB): 665 (M + ) Elementary analysis Calcd. for C 39 H 36 N 8 O 3 (%): C, 70.46; H, 5.46; N, 16.86. Found: C, 70.55; H, 5.40; N, 16.71. Example 27: Process B, Step (n) Synthesis of 4-[[(S)-1-[[4-(2-carboxybenzamido)-3-methyl]phenyl]methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-6-yl]carbonyl)-morpholine (I-23) A solution of phthalic anhydride (0.3236 g, 0.00219 mol) in ethyl acetate (3.3 ml) was added to a solution of the compound (I'-1) (0.8007 g, 0.00146 mol) in ethyl acetate (12 ml) with stirring at room temperature, and the mixture was stirred for 23 hours. The reaction mixture was filtered, and the resulting white solid was washed with ethyl acetate and dried to obtain the objective compound (I-23) (0.8691g; m.p. 191-196°C ; yield: 85.5%). 1 H-NMR (D 2 O+NaOD) δ: 2.24 (s, 3H), 2.30, 2.75 (each dd, 1H, J=5.6, 16.1 Hz), 2.95, 3.11 (each, d, 1H, J=16.1 Hz), 3.2-3.8 (b, 8H), 3.9-4.1 (m, 1H), 5.70 (b, 1H), 6.9-8.0 (m, 17H), 9.7 (b, 1H). MASS (FAB) : 698 (M + ). Elementary analysis Calcd. for C 41 H 39 N 5 O 6 (%): C, 70.57; H, 5.63; N, 10.04. Found: C, 70.79; H, 5.48; N, 10.01. The compounds shown in Tables 18 and 19 were synthesized in the similar way. There were also similarly synthesized the compounds shown in Table 20. Example 28: Process B, Step (o) Synthesis of (S)-3-(2-n-butyl-1-triphenylmethyl-imidazol-5-yl)-2-(triphenylmethylamino)propan-1-ol (XXIV-3) A 1.0 M (nBu) 4 NF/THF solution (2.6 ml, 0.00258 mol) was added to a solution of the compound (XIX-3) in dry THF (10 ml) with stirring under ice cooling, and the mixture was stirred under ice cooling for 30 minutes and further at room temperature for 3 hours. The reaction mixture was poured into water and extracted with EtOAc. The organic layer was washed with a saturated NaCl aqueous solution, dried over Na 2 SO 4 , and concentrated to obtain a white foamy material (1.0896 g, 100% up). This material was purified by silica gel column chromatography (hexane/acetone = 5/1) to obtain the objective compound (XXIV-3) (0.7912 g; yield: 89.8%) as a white foamy material. 1 H-NMR (CD 2 Cl 2 ) δ: 0.59 (t, 3H, J=7.3 Hz), 0.91 (sext, 2H, J=7.3 Hz), 1.11 (quint, 2H, J=7.3 Hz), 1.55 (bs, 1H, OH), 1.78-1.85 (m, 3H), 2.03 (b, 1H, N H ), 2.23 (dd, 1H, J=3.2, 14.4 Hz), 2.80 (b, 1H, C H ), 2.95 (dd, 1H, J=6.4, 11.5 Hz), 3.48 (dd, 1H, J=3.2, 11.5 Hz), 6.14 (s, 1H), 7.10-7.51 (m, 30H). IR (ν max , KBr): 3452, 3105, 2900, 2975, 2905, 1510, 1456, 1410, 1160, 1036, 766, 744, 702, 640 cm -1 . There were similarly synthesized the compounds shown in Table 21. Compound No. R 1 Elementary Analysis Calcd. for (C, H, N) (%) Found (C, H, N) (%) MS(EI) XXIV-1 nPr C 47 H 45 N 3 O 84.52, 6.79, 6.29 84.71, 6.66, 6.10 668 XXIV-2 iPr C 47 H 45 N 3 O 84.52, 6.79, 6.29 84.69, 6.71, 6.11 668 XXIV-3 nBu C 48 H 47 N 3 O 84.54, 6.95, 6.16 84.70, 6.84, 6.08 682 XXIV-4 nHex C 50 H 51 N 3 O 84.59, 7.24, 5.92 84.72, 7.15, 5.88 710 Example 29: Process B, Step (p) Synthesis of (S)-3-(2-n-butyl-1-triphenylmethylimidazol-5-yl)-2-(triphenylmethylamino)propanoic acid (XXV-3) PDC (0.7845 g, 0.00208 mol) was added to a solution of the compound (XXIV-3) (0.4063 g, 0.000596 mol) in DMF (4.0 ml) and stirred at room temperature for 8 hours. The reaction mixture was poured into water and extracted with CH 2 Cl 2 . The organic layer was washed with water and then with a saturated NaCl aqueous solution, dried over Na 2 SO 4 , and concentrated to obtain a reddish brown oily product (0.5745 g, 100% up). This product was purified by silica gel column chromatography (hexane/acetone = 2/1 → 1/2 and CHCl 3 /MeOH = 30/1) to obtain the objective compound (XXV-3) (0.1256 g; yield: 39.3%) as a light-yellow oily material. 1 H-NMR (CDCl 3 ) δ: 0.59 (t, 3H, J=7.3 Hz), 0.91 (sext, 2H, J=7.3 Hz), 1.16 (quint, 2H, J=7.3 Hz), 1.68-1.79 (m, 3H), 2.31 (dd, 1H, J=9.1, 15.3 Hz), 3.53 (d, 1H, J=9.1 Hz), 5.93 (s, 1H), 7.04-7.45 (m, 30H). IR (ν max , KBr): 3025, 2980, 1715, 1608, 1510, 1460, 1410, 1390, 1370, 1190, 1158, 910, 730, 703 cm -1 . The compounds shown in Table 22 were synthesized in the similar way. Compound No. R 1 Elementary analysis Calcd. for (C, H, N) (%) Found (C, H, N) (%) MS(FAB) XXV-1 nPr C 47 H 43 N 3 O 2 82.79, 6.36, 6.16 82.93, 6.27, 6.03 682(M + ) XXV-2 iPr C 47 H 43 N 3 O 2 82.79, 6.36, 6.16 82.88, 6.29, 6.08 682(M + ) XXV-3 nBu C 48 H 45 N 3 O 2 82.85, 6.52, 6.04 83.01, 6.44, 5.95 696(M + ) XXV-4 nHex C 50 H 49 N 3 O 2 82.95, 6.82, 5.80 83.11, 6.74, 5.68 724(M + ) Example 30: Process B, Step (q) Synthesis of (S)-2-amino-3-(2-n-butyl-1H-imidazol-5-yl)propanoic acid (XXV'-3) and (S) -2-n-butyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrochloride (XXVI-3) A 1 N HCl aqueous solution (3.3 ml) and a 37% HCHO solution (0.2 ml) were added to the compound (XXV-3) (0.3308 g, 0.000475 mol) and stirred at room temperature for 40 minutes and then in a 120°C oil bath for 4 hours. After the reaction mixture was cooled, the insoluble portion was filtered out and washed with water. The aqueous layer was washed with Et 2 O, then concentrated, and dried to obtain the objective compound (XXVI-3) (0.1401 g; yield: 99.5%) as a yellow viscous material. 1 H-NMR (D 2 O+NaOD) δ: 0.95 (t, 3H, J=7.3 Hz), 1.40 (sext, 2H, J=7.3 Hz), 1.80 (quint, 2H, J=7.3 Hz), 3.03 (t, 2H, J=7.3 Hz), 3.0-3.4 (m, 2H), 3.8-4.3 (m, 2H). MS (FAB): 223 (M-2HCl) The compounds shown in Table 23 were similarly synthesized. Compound No. R 1 MS (FAB) XXVI-1 nPr 209(M-2HCl) XXVI-2 iPr 209(M-2HCl) XXVI-3 nBu 223(M-2HCl) XXVI-4 nHex 251(M-2HCl) By using the compound (XXV-3) (0.3001 g, 0.000431 mol) and a 1 N HCl aqueous solution (3.0 ml), the above reaction procedure was repeated without adding the 37% HCHO solution to obtain the compound (XXV'-3) (0.1225 g; yield: 100%) as a yellow viscous material. 1 H-NMR (D 2 O+NaOD) δ: 0.96 (t, 3H, J=7.3Hz), 1.39 (sext, 2H, J=7.3Hz), 1.82 (quint, 2H, J-7.3Hz), 2.5-3.7 (m, 3H), 3.07 (t, 2H, J=7.3Hz), 6.85 (bs, 1H). MASS (FAB): 211 (M-2HCl) There were similarly synthesized the compounds shown in Table 24. Compound No. R 1 MS (FAB) XXV'-1 nPr 197 (M-2HCl) XXV'-2 iPr 197 (M-2HCl) XXV'-3 nBu 211 (M-2HCl) XXV'-4 nHex 239 (M-2HCl) Example 31: Process B, Step (r) Synthesis of (S)-2-n-butyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (XXVII-3) Diphenylacetic acid (0.3114 g, 0.00147 mol), DCCI (0.3027 g, 0.00147 mol), and HBTA (0.1983 g, 0.00147 mol) were dissolved in dry THF (0.8 ml) and stirred at room temperature for 20 minutes. A solution of the compound (XXVI-3) (0.1358 g, 0.000458 mol) in dry THF (2.7 ml), and dry triethylamine (0.13 ml, 0.000963 mol) were added to this mixture, followed by stirring at room temperature for 16 hours. The insoluble portion was filtered out and washed with THF. The filtrate and washings were joined and concentrated to obtain a crude oily product (0.3065 g). This product was dissolved in a 1/1 mixture of THF and MeOH (6.0 ml) and, after addition of a 1 N HCl aqueous solution (2.0 ml), left as it was for 8 hours. Further a 1/1 mixture of THF and MeOH (6.0 ml) and a 1 N NaOH aqueous solution (4.0 ml) were added, and the mixture was left as it was for 8 hours. The reaction mixture was concentrated and the residue was purified by silica gel column chromatography (chloroform/ methanol = 10/1) to obtain the objective compound (XXVII-3) (0.0829 g; yield: 43.3%) as a white foamy material. 1 H-NMR (D 2 O+NaOD) δ: 0.92 (t, 3H, J=7.2 Hz), 1.39 (sext, 2H, J=7.2 Hz), 1.82 (quint, 2H, J=7.2 Hz), 2.3-2.9 (m, 4H), 3.9-4.8 (m, 2H), 5.51 (s, 1H), 5.73 (bs, 1H), 7.1-7.7 (m, 10H). MASS (FAB): 417 (M + ) Elementary analysis Calcd. for C 25 H 27 N 3 O 3 (%): C, 71.92; H, 6.52; N, 10.06. Found: C, 72.08; H, 6.47; N, 9.99. The compounds shown in Table 25 were similarly synthesized. Example 32: Process B, Step (s) Synthesis of (S)-2-n-butyl-1-[(4-methoxycarbonylphenyl)methyl]-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo-[4,5-c]pyridine-6-carboxylic acid (XIV-8) Methyl 4-(bromomethyl)benzoate (0.0521 g, 0.000227 mol) and K 2 CO 3 (0.0314 g, 0.000227 mol) were added to a solution of the compound (XXVII-3) (0.0791 g, 0.000189 mol) in dry DMF (1.6 ml), and the mixture was stirred vigorously at room temperature for 20 hours. The reaction mixture was poured into water, extracted with EtOAc, washed with water, dried over anhydrous sodium sulfate, and concentrated to obtain a light-yellow oily material. This material was purified by silica gel column chromatography (hexane/acetone = 1/2) to obtain the objective compound (XIV-8) (0.0331g; m.p. 176-180°C), its 3-position isomer (0.0382 g) and a mixture of them (0.0018 g; yield: 68.2%) as colorless crystals. MASS (FAB): 566 (M + ) Elementary analysis Calcd. for C 34 H 35 N 3 0 5 (%): C, 72.19; H, 6.24; N, 7.43. Found: C, 72.30; H, 6.21; N, 7.39. Example 33 Receptor binding test Determination of total binding in the presence of each drug to be tested was made in the following way. A test drug of a predetermined concentration (0.025 ml; dissolved in dimethyl sulfoxide, then diluted two-fold with a buffer attached to the Drug Discovery System and used for assay), a tracer (0.025 ml), and a receptor (0.2 ml) were added to make a total volume of 0.25 ml. After incubation (at room temperature for 3 hours for the angiotensin II receptor type 1 (AT 1 ) and at 37°C for one hour for the type 2 (AT 2 )), the reaction mixture was subjected to suction filtration (using GF/C filter paper for AT 1 and GF/B filter paper for AT 2 ). The filter paper (tracer-receptor complex) after suction filtration was measured by a γ-well counter (ARC-500, Aloka). The non-specific binding was determined by the similar operation by using a large excess of displacer. The specific binding at the predetermined concentration of the test drug was calculated by deducting the non-specific binding from the total binding. The ratio (%) at which the test drugs inhibit binding between radioactive ligand and receptor was determined for both AT 1 and AT 2 by using the test drugs of the predetermined concentration and a control drug. The compound of the present invention competes with both of the angiotensin II receptors AT 1 and AT 2 , but it is noted that the compound of the formula (I) wherein R 1 is H competes specifically with AT 2 and that of the formula (I) wherein R 1 is other than H competes specifically with AT 1 . In USP 5,091,390, it is stated that the compounds claimed therein, including some reference compounds described below, compete selectively with AT 2 regardless of R 1 , -but the present inventors found that the compound of the present invention and the reference compounds compete specifically with one of AT 1 and AT 2 receptors according to the difference of R 1 , and that the activity of the compound of the present invention far excels that of the reference compounds. Binding inhibition ratio (%) of the test compounds at 1 µM Test compound AT 1 AT 2 Compound I-1 0 100 Compound I-2 0 100 Compound I-7 0 100 Compound 1-12 100 0 Compound I-17 100 0 Compound 1-19 100 0 Compound 1-21 0 100 Compound I-23 0 100 Compound I-24 0 100 Compound 1-30 100 0 Compound 1-31 100 0 Compound I-32 100 0 Compound 1-40 100 0 Reference compound PD123177 0 65 Reference compound DuP753 70 0 Reference compound 1 0 71 Reference compound 2 0 72 Reference compound 26 78 0 Reference compound 27 0 76 Reference compound 50 75 0 PD123177 and DuP753 are disclosed in Bioorganic & Medical Chemistry Letters, 1(12), 711-716, 1991. Comparative substances 1, 2, 26, 27 and 50 are the compounds disclosed in USP 5,091,390: Reference compound R 1 R 2 R 3 X R 4 R 6 1 H COOH COCH(Ph) 2 NHCO COOH 3-CH 3 2 H COOCH 3 COCH(Ph) 2 NHCO COOH 3-CH 3 26 C 3 H 7 COOH COCH(Ph) 2 single bond tetrazolyl 3-CH 3 27 H COOH COCH(Ph) 2 single bond tetrazolyl H 50 C 3 H 7 COOH COCH(Ph) 2 single bond tetrazolyl H

Claims: A compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein R 1 represents hydrogen, halogen, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, R 20 (CH 2 ) n - wherein R 20 represents C 3 -C 8 cycloalkyl, naphthyl, phenyl, or phenyl substituted with one to five of C 1 -C 4 alkyl, halogen atom, trifluoromethyl, hydroxy, C 1 -C 4 alkoxy, C 1 -C 3 acyloxy, amino, N-mono-C 1 -C 4 alkylamino, N-di-C 1 -C 4 alkylamino, C 1 -C 4 thioalkyl, C 1 -C 3 alkylsulfonyl, nitro, and -NHCOR 21 wherein R 21 represents C 1 -C 3 alkyl, phenyl, C 1 -C 3 alkylphenyl, aminophenyl, or C 1 -C 4 alkylaminophenyl, and n is an integer of 1 to 6, R 20 -C(O)- wherein R 20 is as defined above, or R 20 -CH(OH)- wherein R 20 is as defined above; R 2 represents carbamoyl, mono- or di-C 1 -C 6 alkylcarbamoyl, or 4- to 6-membered heterocyclic carbamoyl; R represents amino, carboxy, (1H-tetrazol-5-yl)phenyl, carboxyphenyl, carboxybenzamido, (1H-tetrazol-5-yl)benzamido, carboxyphenylcarbamoyl, or (1H-tetrazol-5-yl)-phenylcarbamoyl; R 3 represents -CH 2 (phenyl), -CH(phenyl) 2 , -CH(phenyl)CH 3 , -CH(phenyl) (cyclohexyl), -CH 2 CH 2 (phenyl), -CH 2 (C 1 -C 6 alkoxyphenyl), or -CH 2 (hydroxyphenyl); and R 4 , R 7 , and R 8 each independently represents hydrogen or C 1 -C 6 alkyl. A compound or a pharmaceutically acceptable salt thereof according to claim 1, wherein R 1 is hydrogen or C 1 -C 6 alkyl; R 2 is -CONH 2 , -CONHCH 3 , -CON(CH 3 ) 2 , -CONH(C 2 H 5 ), -CON(C 2 H 5 ) 2 , R is amino, carboxy, 2-(1H-tetrazol-5-yl)phenyl, 2-carboxyphenyl, 2-carboxybenzamido, 2-(1H-tetrazol-5-yl)benzamido, 2-carboxyphenylcarbamoyl, or 2-(1H-tetrazol-5-yl)phenylcarbamoyl; R 3 is -CH(phenyl) 2 , -CH 2 (phenyl), -CH(phenyl)CH 3 , -CH(phenyl) (cyclohexyl), -CH 2 CH 2 (phenyl), -CH 2 (p-methoxyphenyl), or -CH 2 (p-hydroxyphenyl); and R 4 , R 7 , and R 8 each independently is hydrogen or C 1 -C 2 alkyl. A compound of formula (XXX): or a salt thereof; wherein R 1 , R 4 , R 7 and R 8 are as defined in claim 1 or 2; R 3' is hydrogen, -COCH 2 (phenyl), -COCH(phenyl) 2 , -COCH(phenyl) CH 3 , -COCH (phenyl) (cyclohexyl), -COCH 2 CH 2 (phenyl), -COCH 2 (C 1 -C 6 alkoxyphenyl), or -COCH 2 (hydroxyphenyl) ; R 6 is nitro, (1-triphenylmethyl-1H-tetrazol-5-yl)phenyl, cyano, 2-(1-trifluoromethyl-1H-tetrazol-5-yl)phenyl, C 1 -C 3 alkoxycarbonyl, cyanophenyl or 2-cyanophenyl; and R 15' represents -CH 2 -R 19 or -C(O)-R 19 wherein R 19 represents hydrogen or C 1 -C 6 alkyl. A compound or a salt thereof according to claim 3, wherein R 1 is hydrogen or C 1 -C 6 alkyl; R 3' is -COCH(phenyl) 2 or -COCH(phenyl) (cyclohexyl); R 6 is nitro, 2-(1-triphenylmethyl-1H-tetrazol-5-yl)phenyl, cyano, methoxycarbonyl, or 2-cyanophenyl; R 4 , R 7 , and R 8 each independently is hydrogen or C 1 -C 2 alkyl; and R 19 is hydrogen or C 1 -C 2 alkyl. A compound of formula (XIII): or a salt thereof; wherein R 1 , R 3 , R 4 , R 7 and R8 are as defined in claim 1 or 2; R 6 is as defined in claim 3; and R 2' represents amino, mono or di-C 1 -C 6 alkylamino, or 4- to 6-membered heterocyclic amino. A compound or a salt thereof according to claim 5, wherein R 1 is hydrogen or C 1 -C 6 alkyl; R 2 is -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NH(C 2 H 5 ), N(C 2 H 5 ) 2 , R 3 is -CH(phenyl) 2 , or CH(phenyl)(cyclohexyl); R 4 , R 7 , and R 8 each independently is hydrogen or C 1 -C 2 alkyl; and R 6 is nitro, 2-(1-triphenylmethyl-1H-tetrazol-5-yl)phenyl, methoxycarbonyl, cyano, or 2-cyanophenyl. A compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 1 or 2 for use in a method of treatment of the human or animal body by therapy. A compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 1 or 2 for use as an angiotensin II antagonist. Use of a compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 1 or 2 in the manufacture of a medicament for use as an angiotensin II antagonist. An angiotensin II antagonist composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 1 and a pharmaceutically acceptable diluent. A compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 1 or 2 with the proviso that R 1 is not hydrogen for use as an angiotensin II AT 1 receptor antagonist. A compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 1 or 2 wherein R 1 is hydrogen for use as an angiotensin II AT 2 receptor antagonist. A process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof as defined in claim 1 or 2, which comprises: (i) reacting a compound of formula (II): wherein R 1 , R 3 , R 4 , R 7 and R 8 are as defined in claim 1 and R 2' is amino, mono- or di-C 1 -C 6 alkylamino, or 4- to 6- membered heterocyclic amino, or a salt thereof, with an appropriate benzoic acid derivative at 10 to 40°C for 10 to 24 hours; (ii) hydrolysing a compound of formula (XIII) or a salt thereof as defined in claim 5 wherein R 6 is cyanophenyl; (iii) reacting a compound of formula (IV): wherein R 1 , R 3 , R 4 , R 7 and R 8 are as defined in claim 1 and R 6 is (1H-tetrazol-5-yl)phenyl or a salt thereof with an appropriate nitrogen-containing compound at 10 to 40°C for 10 to 24 hours; (iv) reacting a compound of formula (XIII) or a salt thereof as defined in claim 5 wherein R 6 is C 1 -C 3 alkoxycarbonyl with an alkali at 10 to 40°C for 1 to 24 hours; (v) reacting a compound of formula (XIII) or a salt thereof as defined in claim 5 wherein R 6 is nitro with tin chloride or tin chloride dihydrate under an inert gas atmosphere at 10 to 100°C for 0.1 to 1 hour; (vi) reacting a compound of formula (XIII) or a salt thereof as defined in claim 5 wherein R 6 is cyanophenyl with trimethyltin azide or tributyltin azide under an inert gas atmosphere at 100 to 120°C for 12 to 120 hours followed by treatment with an acid; or (vii) reacting a compound of formula (XIII) or a salt thereof as defined in claim 5 wherein R 6 is ((1-triphenylmethyl)-1H-tetrazol-5-yl)phenyl with an acid at 10 to 100°C for 0.1 to 6 hours; and, if desired, converting a compound of formula (I) into another compound of formula (I), and/or, if desired, converting a compound of formula (I) into a pharmaceutically acceptable salt thereof, and/or, if desired, converting a salt into a free compound.

Inventors: ENARI HIROYUKI, YANAKA MIKIRO, ENARI, HIROYUKI, YANAKA, MIKIRO
Applicants: KUREHA CHEMICAL IND CO LTD, KUREHA KAGAKU KOGYO KABUSHIKI KAISHA
Application year: 1993
Main classification: C07D471
IPC codes: C07D471, C07D233