SUCCINOYLAMINO HYDROXYETHYLAMINO SULFAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS

Abstract: Succinoylamino hydroxyethylamino sulfamic acid derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

Description: SUCCINOYLAMINO HYDROXYETHYLAMINO SULFAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to retroviral protease inhibitors and, more particularly, relates to novel compounds and a composition and method for inhibiting retroviral proteases. This invention, in particular, relates to suifamic acid-containing hydroxyethylamine protease inhibitor compounds, a composition and method for inhibiting retroviral proteases such as human immunodeficiency virus (HIV) protease and for treating a retroviral infection, e.g., an HIV infection. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. 2. Related Art During the replication cycle of retroviruses, gag and gag-pol gene products are translated as proteins. These proteins are subsequently processed by a virally encoded protease (or proteinase) to yield viral enzymes and structural proteins of the virus core. Most commonly, the gag precursor proteins are processed into the core proteins and the pol precursor proteins are processed into the viral enzymes, e.g., reverse transcriptase and retroviral protease. It has been shown that correct processing of the precursor proteins by the retroviral protease is necessary for assembly of infectious virons. For example, it has been shown that frameshift mutations in the protease region of the pol gene of HIV prevents processing of the gag precursor protein. It has also been shown through site-directed mutagenesis of an aspartic acid residue in the HIV protease that processing of the gag precursor protein is prevented. Thus, attempts have been made to inhibit viral replication by inhibiting the action of retroviral proteases. Retroviral protease inhibition may involve a transition-state mimetic whereby the retroviral protease is exposed to a mimetic compound which binds to the enzyme in competition with the gag and gag-pol proteins to thereby inhibit replication of structural proteins and, more importantly, the retroviral protease itself. In this manner, retroviral replication proteases can be effectively inhibited. Several classes of compounds have oeen proposed, particularly for inhibition of proteases, such as for inhibition of HIV protease. Such compounds include hydroxyethylamine isosteres and reduced amide isosteres. See, for example, EP 0 346 847; EP 0 342,541; Roberts et al, "Rational Design of Peptide-Based Proteinase Inhibitors, "Science, 248, 358 (1990); and Erickson et al, "Design Activity, and 2.8A Crystal Structure of a C2 Symmetric Inhibitor Complexed to HIV-l Protease, " Science, 249, 527 (1990) . Several classes of compounds are known to be useful as inhibitors of the proteolytic enzyme renin. See, for example, U.S. No. 4,599,198; U.K. 2,184,730; G.B. 2,209,752; EP 0 264 795; G.B. 2,200,115 and U.S. SIR H725. Of these, G.B. 2,200,115, GB 2,209,752. EP 0 264,795, U.S. SIR H725 and U.S. 4,599,198 disclose urea- containing hydroxyethylamine renin inhibitors. G.B. 2,200,115 also discloses suifamic acid-containing hydroxyethylamine renin inhibitors, and EP 0264 795 discloses certain suifamic acid-containing hydroxyethylamine renin inhibitors. However, it is known that, although renin and HIV proteases are both classified as aspartyl proteases, compounds which are effective renin inhibitors generally cannot be predicted to be effective HIV protease inhibitors. BRIEF DESCRIPTION OF THE INVENTION The present invention is directed to virus inhibiting compounds and compositions. More particularly, the present invention is directed to retroviral protease inhibiting compounds and compositions, to a method of inhibiting retroviral proteases, to processes for preparing the compounds and to intermediates useful in such processes. The subject compounds are characterized as suifamic acid-containing hydroxyethylamine inhibitor compounds. DETAILED DESCRIPTION OF THE INVENTION In accordance with the present invention, there is provided a retroviral protease inhibiting compound of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof wherein: Rl represents hydrogen, -CH2SO2NH2 , -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3 ) 2 (SCH3) , -C(CH3)2 (S[0]CH3) , -C (CH3)2 (S [0]2CH3 ) , alky.., haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, .alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-alkyl serine, aspartic acid, beta-cyanoalanine and valine side chains; R2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radials, -NO2, -CN, -CF3, -OR9 and -SR9, wherein R9 represents hydrogen and alkyl radicals; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said subεtituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone and sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R3 or together with a nitrogen atom to which they are bonded form a heterocycloalkyl or a heteroaryl radical; R6 represents hydrogen and alkyl radicals; R30, R31 and R32 independently represent radicals as defined for R1, or one of RI and R 0 together with one of R31 and R 2 and the carbon atoms to which they are attached form a cycloalkyl radical; R 3 and R34 independently represent hydrogen and radicals as defined for R , or R 3 and R 4 together with X' represent cycloalkyl, aryl, heterocyclyl and heteroaryl radicals, provided that when X' is O, R34 J S absent; x represents 1 or 2; X' represents N, 0 and C(R-^^) wherein R*^- 7 represents hydrogen and alkyl radicals; t represents either 0, 1 or 2; and Y and Y' independently represent 0, S and NR^-5 wherein R-L5 represents hydrogen and radicals as defined for R . A family of compounds of particular interest within Formula I are compounds embraced by Formula II: wherein : Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3)2 (SCH3 ) , -C(CH3)2 (S[0]CH3) , -C(CH3)2 (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine, methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-methyl serine, aspartic acid, beta-cyanoalanine and valine side chains; R2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R9 represents hydrogen and alkyl radicals; R represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone and sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R3 , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals; R 0, R31 anc j R32 independently represent radicals as defined for R^, or one of R 1 and R-^O together with one of R 1 and R 2 and the carbon atoms to which they are attached form a cycloalkyl radical; R 3 and R 4 independently represent hydrogen and radicals as defined for R , or R 3 and R 4 together with the nitrogen atom to which they are attached represent heterocycloalkyl and heteroaryl radicals; and Y and Y' independently represent 0, S and NR----5 wherein R^5 represents hydrogen and radicals as defined for R . A more preferred family of compounds within Formula II consists of compounds wherein: Rl represents hydrogen and CH 2 C (C NHCH 3 , C (CH 3 ) 2 (SCH 3 ) , C(CH 3 ) 2 (S[0]CH 3 ) , C(CH 3 ) (S[0] 2 CH 3 ) , alkyl, alkenyl and alkynyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, threonine, allo-threonine, isoleucine, tert-leucine, S-methyl cysteine and the sulfone and sulfoxide derivatives thereof, alanine, and allo-isoleucine; R represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented oy the formula -OR9 and -SR9 wherein R9 represents alkyl xadicals; and R represents alkyl, haloalkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl and heteroaralkyl radicals; R 4 and R 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals, or R^ and R^ together with the nitrogen atom to which they are bonded form a heterocycloalkyl or heteroaryl radical; R 0, R 3i an( j R 32 independently represent hydrogen and alkyl, alkenyl and alkynyl radicals, or one of RI and R 0 together with one of R31 and R 2 and the carbon atoms to which they are attached form a cycloalkyl radical; R3 and R34 independently represent hydrogen and alkyl, alkenyl and alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl radicals; and Y and Y' represent O. Of highest interest are compounds within Formula II wherein Rl represents hydrogen and CH 2 C (0)NHCH 3 , C (CH 3 ) 2 (SCH 3 ) , C(CH 3 ) 2 (S[0]CH 3 ) , C(CH 3 ) 2 (S[0] 2 CH 3 ) , methyl, erhyl, propargyl, t-butyl, isopropyl and sec-butyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, S-methyl cysteine, methionine, allo-iso-leucine, iso-leucine, and beta-cyano alanine side chains; R 2 represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals; R represents propyl, isoamyl, n-butyl, isobutyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals; R4 and R 5 independently represent hydrogen and methyl, ethyl, i-propyl, propyl, n-butyl, t-butyl, 1, 1-dimethyIpropyl and phenyl radicals, or together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl, pioerazinyl or N' -alkylpiperazinyl radical; R3C ) , R 3i an R 32 independently represent h drogen and methyl, ethyl, propyl, butyl, pentyl and hexyl radicals, or one of R! and R 0 together with one of R31 and R form a cycloalkyl radical having from 3 to 8 carbon atoms; R3 and R 4 independently represent methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl, pentyl and hexyl radicals, cyclohexylmethyl, cyclohexyl, benzyl and naphthylmethyl radicals; and Y and Y' represent O. Another family of compounds of particular interest within Formula I are compounds embraced by Formula III: wherein : Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH < 2 (SCH3 ) , -C(CH3)2 (S[0]CH3) , -C(CH3)2 (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chains selected from asparagine, S-methyl cysteine, methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, aspartic acid, beta-cyano alanine and valine side chains; R2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, -NO2, -C≡N, CF 3 -OR9, -SR9, wherein R represents hydrogen and alkyl; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom t.o which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone and sulfoxide derivatives thereof; R4 and R^ independently represent hydrogen and radicals as defined for R3 or together with a nitrogen atom to which they are bonded form a heterocycloalkyl or a heteroaryl radical; and R 0, R 31 anc j R 32 independently represent radicals as defined for R--*-, or one of R^ and R 0 together with one of R 1 and R 2 and the carbon atoms to which chey are attached form a cycloalkyl radical; R represents hydrogen and radicals as defined for R . A more preferred family of compounds within Formula III consists of compounds wherein R***- represents hydrogen, alkyl, alkenyl and alkynyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, threonine, allo- threonine, isoleucine, tert-leucine, S-methyl cysteine and the sulfone and sulfoxide derivatives thereof, methionine and the sulfone and sulfoxide derivatives thereof, alanine, and allo-isoleucine; R2 represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicals and radicals represented by the formula -OR9 and -SR9 wherein R9 represents hydrogen and alkyl radicals; R3 represents alkyl, haloalkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl radicals; R 4 and R 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals, or R 4 and R 5 together with the nitrogen atom to which they are bonded from a heterocycloalkyl or heteroaryl radical; and R 0, R31 and R independently represent hydrogen and alkyl, alkenyl and alkynyl radicals, or one of ΕX and R30 together with one of R31 and R 2 and the carbon atoms to which they are attached form a cycloalkyl radical; R represents hydrogen, alkyl, alkenyl and alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl and heteroaralkyl radicals. Of highest interest are compounds within Formula III wherein Rl represents hydrogen, methyl, ethyl, propargyl, t-butyl and sec-butyl radicals, and amino acid side chains selected from the group consisting of asparagine, valine, S-methyl cysteine, methionine, allo-iso-le cine, iso- leucine, threonine, serine, aspartic acid, beta-cyano alanine, and allo-threonine side chains; R 2 represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals; R 3 represents propyl, isobutyl, isoamyl, n-butyl, cyclohexyl, cyclohexylmethyl, benzyl and pyiidylmethyl radicals; R4 and R 5 independently represent hydrogen and methyl, ethyl, i-propyl, n-butyl, t-butyl, 1, 1-dimethyIpropyl and phenyl radicals, or R4 and R 5 together with the nitrogen atom to which they are bonded form a pyrroiidinyl, piperidinyl, morpholinyl or piperazinyl radical; and R30, R 3i an R 32 independently represent hydrogen and methyl, ethyl, propyl, butyl, pentyl and hexyl radicals, or one of R 1 and R 0 together with one of R 1 and R form a cycloalkyl radical having from 3 to 8 carbon atoms; and R 3 represents hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary-butyl, pentyl and hexyl radicals, cyclohexylmethyl, cyclohexyl, benzyl and naphthylmethyl radicals. As utilized herein, the term "alkyl", alone or in combination, means a straight-chain or ranched-chain alkyl radical containing from 1 to about 10, preferably from 1 to 8, carbon atoms. Examples of such radicals include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, iso-amyl, hexyl, octyl and the like. The term "alkenyl", alone or in combination, means a straight-chain or brauched-chain hydrocarbon radial having one or more doubie bonds and containing from 2 to about 18 carbon atoms preferably from 2 to 8 carbon atoms. Examples of suitable alkenyl radicals include ethenyl, propenyl, 1, 4-but.-.dιenyl, 12-octadecene and the like. The term "alkynyl", alone or in combination, means a straight-chain hydrocarbon radical having one or more triple bonds and containing from 2 to about 10 carbon atoms, preferably from 2 to 8 carbon atoms. Examples of alkynyl radicals include ethynyl, propynyl, (propargyl), butynyl and the like. The term "alkoxy", alone or in combination, means an alkyl ether radical wherein the term alkyl is as defined above. Examples of suitable alkyl ether radicals include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, iso-butoxy, sec-butoxy, tert-butoxy and the like. The term "cycloalkyl", alone or in combination, means a saturated or partially saturated monocyclic, bicyclic or tricyclic alkyl radical wherein each cyclic moiety contains from about 3 to about 8 carbon atoms and is cyclic. The term "cycloalkylalkyl" means :.n alkyl radical as defined above which is substitured by a cycloalkyl radical containing from about 3 to about 8, preferably from 3 to 6 carbon atoms. Examples of such cycloalkyl radicals include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and the like. The term "aryl", alone or in combination, means a phenyl or naphthyl radical which optionally carries one or more substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, nitro, cyano, haloalkyl and the like, such as phenyl, p-tolyl, 4-methoxyphenyl, 4- (tert-butoxy)phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-hydroxyphenyl, 1-naphthyl, 2-naphthyl, and the like. The term "aralkyl", alone or in combination, means an alkyl radical as defined above in which one hydrogen atom is replaced by an aryl radical as defined e, such as benzyl, 2-phenylethyl and the like. The term "aralkoxy carbonyl", alone or in combination, means a radical of the formula -C (O) -O-aralkyl in which the term "aralkyl" has the significance given above. An example of an aralkoxycarbonyl radical is benzyloxycarbo yl. The term "aryloxy" means a radical of the formula aryl-O- in which the term aryl has the significance given above. The term "alkanoyl", alone or in combination, means an acyl radical derived from an alkanecarboxylic acid wherein alkane means a radical as defined above for alkyl. Examples of alkanoyl radicals include acetyl, propionyl, butyryl, valeryl, 4-methylvaleryl, and the like. The term "cycloalkylcarbonyl" means an acyl group derived from a monocyclic or bridged cycloalkanecarboxylic acid such as cyclopropanecarbonyl, cyclohexanecarbonyl, adamantanecarbonyl, and the like, or from a benz-fused monocyclic cycloalkanecarboxylic acid which is optionally substituted by, for example, alkanoylamino, such as 1,2,3, 4-tetrahydro-2-naρhthoyl,2-acetamido-l,2,3,4- tetrahydro-2-naphthoyl. The term "aralkanoyl" means an acyl radical derived from an aryl-substit tfr] alkanecarboxylic acid such as phenylacetyl, 3-phenylpropionyl (hydrocinnamoyl) , 4-phenylbutyryl, (2-naphthyl)acetyl, 4-chlorohydrocinnamoyl. 4-aminohydrocinnamoyl, 4-methoxyhydrocinnamoyl, and the like. The term "aroyl" means an acyl radical derived from an aromatic carboxylic acid. Examples of such radicals include aromatic carboxylic acids, an optionally substituted benzoic or naphthoic acid such as benzoyl, 4-chlorobenzoyl, 4-carboxybenzoyl, 4- (benzyloxycarbonyl)benzoyl, 1-naphthoyl, 2-naphthoyl, 6-carboxy-2 naphthoyl, 6- (benzyloxycarbony ) -2-naphthoyl, 3-benzyloxy-2-naphthoyl, 3-hydroxy-2-naphthoyl, 3- (benzyloxyformamido) -2-naphthoyl, and the like. The heterocyclyl or heterocycloalkyl portion of i*> heterocyclylcarbonyl, heterocyclyloxycarbor.-*-1. heterocyclylalkoxycarbonyl, or heterocyclyalkyl group or the like is a saturated or partially unsaturated monocyclic, bicyclic or tricyclic heterocycle which contains one or more hetero atoms selected from nitrogen, oxygen and sulphur, which is optionally substituted on one or more carbon atoms by halogen, alkyl, alkoxy, oxo, and the like, and/or on a secondary nitrogen atom (i.e., -NH-) by alkyl, aralkoxycarbonyl, alkanoyl, phenyl or phenylalkyl or on a tertiary nitrogen atom (i.e. = N-) by oxido and which is attached via a carbon atom. The heteroaryl portion of a heteroaroyl, heteroaryloxycarbonyl, or a heteroaralkoxy carbonyl group or the like is an aromatic monocyclic, bicyclic, or tricyclic heterocycle which contains the hetero atoms and is optionally substituted as defined above with respect to the definition of heterocyclyl. Such heterocyclyl and heteroaryl radicals have from four to about. 12 ring members, preferably from 4 to 10 ring members. Examples of such heterocyclyl and heteroaryl groups are pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiamorpholinyl, pyrrolyl, imidazolyl (e.g., imidazol 4-yl, l-benzyloxycarbonylimidazol-4-yl, etc.), pyrazolyl, pyridyl, pyrazinyl, pyrimidinyl, furyl, thienyl, triazolyl, oxazolyl, thiazolyl, indolyl (e.g., 2-indolyl, etc.), quinolinyl, (e.g., 2-quinolinyl, 3-quinolinyl, l-oxido-2-quinolinyl, etc.), isoquinolinyl (e.g., 1-isoquinolinyl, 3-isoquinolinyl, etc.) , tetrahydroquinolinyl (e.g., 1,2, 3, 4-tetrahydro-2- quinolyl, etc.), 1,2, 3 ,4-tetrahydroisoquinolinyl (e.g., 1,2,3, 4-tetrahydro-l-oxo-isoquinolinyl, etc. ) , quinoxalinyl, β-carbolinyl, 2-benzofurancarbonyl, l-,2-,4- or 5-benzimidazolyl, and the like. The term "cycloalkylalkoxycarbonyl" means an acyl group derived from a cycloalkylalkoxycarboxylic acid of the formula cycloalkylalkyl-O-COOH wherein cycloalkylalkyl has the significance given above. The term "aryloxyalkanoyl" means an acyl radical of the formula aryl-G-alkanoyl wherein aryl and alkanoyl have the significance given above. The term "heterocyclyloxycarbonyl" means an acyl group derived from heterocyclyl-O-COOH wherein heterocyclyl is as defined above. The term "heterocyclylalkanoyl" is an acyl radical derived from a heterocyclyl-substituted alkane carboxylic acid wherein heterocyclyl has the significance given above. The term "heterocyclylalkoxycarbonyl" means an acyl radical derived from a heterocyclyl-substituted alkane-O-COOH wherein heterocyclyl has the significance given above. The term "heteroaryloxycarbonyl" means an αcyl radical derived from a carboxylic acid represented by heteroaryl- O-COOH wherein heteroaryl has the significance given above. The term "aminocarbonyl" alone or in combination, means an amino-substituted carbonyl (carbamo . ' *./ group derived from an amino-substituted carboxylic acid wherein the amino group can be a primary, secondary or tertiary amino group containing substituents selected from hydrogen, and alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl radicals and the like. The. term "aminoalkanoyl" means an acyl group derived from an amino-substituted alkanecarboxylic acid wherein the amino group can be a primary, secondary or tertiary amino group containing substituents selected from hydrogen, and alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl radicals and the like. The term "halogen" means fluorine, chlorine, bromine or iodine. Tht- term "haloalkyl" means an alkyl radical having the significance as defined above wherein one or more hydrogens are replaced with a halogen. Examples of such haloalkyl radicals include chloromethyl, 1-bromoethyl, fluoromethyl, difluoromethyl, trifluoromet yl, 1, 1, 1-trifluoroethyl and the like. The te.m "leaving group" generally refers to groups readily displaceable by a nucleophile, such as an amine, a thiol or an alcohol nucleophile. Such leaving groups are well known in the art. Examples of such leaving groups include, but are not limited to, N-hydroxysuccinimide, N-hydroxybenzotriazole, halides, triflates, tosylates and the like. Preferred leaving groups are indicated herein where appropriate. Procedures for preparing the compounds of Formula I are set forth below. It should be noted that the general procedure is shown as it relates to preparation of compounds having the specified stereochemistry, for example, wherein the absolute stereochemistry about the hydroxyl group is designated as (R) , which is the preferred stereochemistry for the compounds of the present invention. However, such procedures are generally applicable to those compounds of opposite configuration, e.g., where the stereochemistry about the hydroxyl group is (S) . In addition, the compounds having the (R) stereochemistry can be utilized to produce those having the (S) stereochemistry. For example, a compound having the (R) stereochemistry can be inverted to the (S) stereochemistry using well-known methods. Preparation of Compounds of Formula I The compounds of the present invention represented by Formula I above can be prepared utilizing the following general procedure. This procedure is schematically shown in the following Schemes I and II: SCHEME I a) amine b) sulfamoyl chloride R4R„ 5„NS0 2 C1 (or anhydride] + acid scavenger c) deprotection d) coupling SCHEME II a) amine b) sulfamoyl chloride R , _ R5„ NS0 2 C1 (or anhydride! + acid scavenger c) deprotection d) coupling An N-protected chloroketone derivative of an amino acid having the formula: wherein P represents an amino protecting group, and R2 is as defined above, is reduced to the corresponding alcohol utilizing an appropriate reducing agent. Suitable amino protecting groups are well known in the art and include carbobenzoxy, t-butoxycarbonyl, and the like. A preferred amino protecting group is carbobenzoxy. A preferred N-protected chloroketone is N-benzyloxycarbonyl-L-phenylalanine chloromethyl ketone. A preferred reducing agent is sodium borohydride. The reduction reaction is conducted at a temperature of from -10°C to about 25°C, preferably at about 0°C, in a suitable solvent system such as, for example, tetrahydrofuran, and the like. The N-protected chloroketones are commercially available, e.g., such as from Bachem, Inc., Torrance, California. Alternatively, the chloroketones can be prepared by the procedure set forth in S. J. Fittkau, J. Prakt. Chem. , 315, 1037 (1973), and subsequently N-protected utilizing procedures which are well known in the art. The halo alcohol can be utilized directly, as described below, or, preferably, is then reacted, preferably at room temperature, with a suitable base in a suitable solvent system to produce an N-protected amino epoxide of the formula: wherein P and R are as defined above. Suitable solvent systems for preparing the amino epoxide include ethanol, methanol, isopropanol, tetrahydrofuran, dioxane, and the like including mixtures thereof. Suitable bases for producing the epoxide from the reduced chloroketone include potassium hydroxide, sodium hydroxide, potassium t-butoxide, DBU and the like. A preferred base is potassium hydroxide. Alternatively, a protected amino epoxide can be prepared starting with an L-amino acid which is reacted with a suitable amino-protecting group in a suitable solvent to produce an amino-protected L-amino acid ester of the formula: R 2 P N 0P P 2 ^ O wherein pi and p2 independently represent hydrogen, benzyl and amino-protecting groups (as defined above) , provided that pi and p2 are not both hydrogen; P represents carboxyl-protecting group, e.g., methyl, ethyl, benzyl, tertiary-butyl and the like; and R is as defined above. The amino-protected L-amino acid ester is then reduced, to the corresponding alcohol. For example, the amino-protected L-amino acid ester can be reduced with diisobutylaluminum hydride at -78° C in a suitable solvent such as toluene. The resulting alcohol is then converted, for example, by way of a Swern oxidation, to the corresponding aldehyde of the formula: wherein P^, p and R2 are as defined above. Thus, a dichloromethane solution of the alcohol is added to a cooled (-75 to -68° C) solution of oxalyl chloride in dichloromethane and DMSO in dichloromethane and stirred for 35 minutes. The aldehyde resulting from the Swern oxidation is then reacted with a halomethyllithium reagent, which reagent is generated in situ by reacting an alkyllithium or arylithium compound with a dihalomethane represented by the formula X 1 CH2 ^ wherein χl and X 2 independently represent I, Br or Cl. For example, a solution of the aldehyde and chloroiodomethane in THF is cooled to -78° C and a solution of n-butyllithium in hexane is added. The resulting product is a mixture of diastereomers of the corresponding amino-protected epoxides of the formulas: The diastereomers can be separated e.g., by chromatography, or, alternatively, once reacted in subsequent steps the diastereomeric products can be separated. For compounds having the (S) stereochemistry, a D-amino acid can be utilized in place of the L-amino acid. The amino epoxide is then reacted, in a suitable solvent system, with an equal amount, or preferably an excess of, a desired amine of the formula: wherein R3 is hydrogen or is as defined above. The reaction can be conducted over a wide range of temperatures, e.g., from about 10°C to about 100°C, but is preferably, but not necessarily, conducted at a temperature at which the solvent begins to reflux. Suitable solvent systems include protic, non-protic and dipolar aprotic organic solvents such as, for example, those wherein the solvent is an alcohol, such as methanol, ethanol, isopropanol, and the like, ethers such as tetrahydrofuran, dioxane and the like, and toluene, N,N-dimethylformamide, dimethyl sulfoxide, and mixtures thereof. A preferred solvent is isopropanol. Exemplary amines corresponding to the formula R NH2 include benzyl amine, isobutylamine, n-butyl amine, isopentyl amine, isoamylamine, cyclohexanemethyl amine, naphthylene methyl amine and the like. The resulting product . • a 3-(N- protected amino) -3- (R2) -1- (NHR ) -propan-2-ol derivative (hereinafter referred to as an amino alcohol) can be represented by the formulas: ' wherein P, pi, p2 R2 a nd R3 are as described above. Alternatively, a haloalcohol can be utilized in place of the amino epoxide. The amino alcohol defined above is then reacted in a suitable solvent with a sulfamoyl halide, e.g. sulfamoyl chloride (R 4 R 5 NS02C1 or R 4 HNS02Cl) or sulfamoyl anhydride in the presence of an acid scavenger. Suitable solvents in which the reaction can be conducted include methylene chloride, tetrahydrofuran. Suitable acid scavengers include triethylamine, pyridine. The resulting suifamic acid derivative can be represented, depending on the epoxide utilized, by the formulas; wherein P, P 1 , P 2 , R 2 , R3 t R an( j R 5 are as defined above. These intermediates are useful for preparing inhibitor compounds of the present invention and are also active inhibitors of retroviral proteases. The sulfamoyl halides of the formula R^NHS02X can be prepared by the reaction of a suitable isocyanate of the formula R^NCO with fuming sulfuric acid to produce the corresponding sulfamate which is then converted to the halide by well known procedures, such as by treating the sulfamate with PCI5. Alternatively the isocyanate can be treated with chlorosulfonic acid to produce the corresponding sulfamoyl chloride directly. The sulfamoyl halides of the formula R 4 R 5 NS02C1 can be prepared by reacting an amine of the formula R R5NH, preferably as a salt such as the hydrochloride, with sulfuryl chloride in a suitable solvent such as acetonitrile. The reaction mixture is gradually warmed to reflux temperature and maintained at the reflux temperature until the reaction is complete. Alternatively, sulfamoyl halides of the formula R R- S02C1 can be prepared by reacting an amine of the fomula R R- H with sulfuryl chloride in boiling MeCN as disclosed in Matier et al. , J. Med. Chem.. 1_5_, No. 5, p.538 (1972) . Following preparation of the suifamic acid derivative, the amino protecting group P or X and P 2 amino protecting groups are removed under conditions which will not affect the remaining portion of the molecule. These methods are well known in the art and include acid hydrolysis, hydrogenolysis and the like. A preferred method involves removal of the protecting group, e.g., removal of a carbobenzoxy group, by hydrogenolysis utilizing palladium on carbon in a suitable solvent system such as an alcohol, acetic acid, and the like or mixtures thereof. Where the protecting group is a t-butoxycarbonyl group, it can be removed utilizing an inorganic or organic acid, e.g . HCl or trifluoroacetic acid, in a suitable solvent system, e.g., dioxane or methylene chloride. Where the protecting group is a benzyl radical, it can be removed by hydrogenolysis. The resulting product is the amine salt derivative. Following neutralization of the salt, the amine is then reacted with a succinic acid, or derivative thereof, as described below, to produce the antiviral compounds of the present invention having the formula: wherein t, Rl, R2, R3 , R4, R 5, R30 R 31 # R 32 ; R 33 and R 34 are as defined above. Alternatively, the protected amino alcohol from the epoxide opening can be further protected at the newly introduced amino group with a protecting group P 1 which is not removed when the first protecting P is removed. One skilled in the art can choose appropriate combinations of P and P' . One suitable choice is when P is Cbz and P' is Boc. The resulting compound represented by the formula: can be carried through the remainder of the synthesis to provide a compound of the formula: and the new protecting group P' is selectively removed, and following deprotection, the resulting amine reacted to form the suifamic acid derivative as described above. This selective deprotection and conversion to the suifamic acid can be accomplished at either the end of the synthesis or at any appropriate intermediate step if desired. To produce the succinic acid portion of the compounds of Formula I, the starting material is a lactate of the formula: wherein P" represents alkyl and aralkyl radicals, such as, for example, ethyl, methyl, benzyl and the like. The hydroxyl group of the lactate is protected as its ketal by reaction in a suitable solvent system with methyl isopropenyl ether (1,2-methoxypropene) in the presence of a suitable acid. Suitable solvent systems include methylene chloride, tetrahydrofuran and the like as well as mixtures thereof. Suitable acids include POCI3 and the like. It should be noted that well-known groups other than methyl isopropenyl ether can be utilized to form the ketal. The ketal is then reduced with dii obutylaluminum hydride (DIBAL) at -78°C to produce the corresponding aldehyde which is then treated with ethylidene triphenylphosphorane (Wittig reaction) to produce a compound represented by the formula: The ketal protecting group is then removed utilizing procedures well-known in the art such as by mild acid hydrolysis. The resulting compound is then esterified with isobutyryl chloride to produce a compound of the formula: reaction mixture to room temperature to effect a Claisen rearrangement ([3,3]) to produce the corresponding acid represented by the formula: Those skilled in the art will recognize that variations on this scheme are possible, using either different protecting groups or reagents to carry out the same transformations. One can also utilize other acid chlorides in place of isobutyryl chloride to prepare similar analogs. Treatment of the acid with benzyl bromide in the presence of a tertiary amine base, e.g., DBU, produces the corresponding ester which is then cleaved oxidatively to give a trisubstituted succinic acid: The trisubstituted succinic acid is then coupled to the sulfamate isostere utilizing procedures well known in the art. To produce the free acid, the benzyl ester iε removed by hydrogenolysis to produce the corresponding acid. The acid can then be converted to the primary amide by methods well-known in the art. The resulting product is a compound represented by Formula I. An alternative method for preparing trisubstituted succinic acids involves reacting an ester of acetoacetic acid represented by the formula: where R is a suitable protecting group, such as methyl, ethyl, benzyl or t-butyl with sodium hydride and a hydrocarbyl halide (R31χ or R χ) in a suitable solvent, e.g. , THF, to produce the corresponding disubstituted derivative represented by the formula: This disubstituted acetoacetic acid derivative is then treated with lithium diisopropyl amide at about -10°C and in the presence of PhN(triflate) 2 to produce a vinyl triflate of the formula: The vinyl triflate is then carbonylated utilizing a palladium catalyst, e.g., Pd(θAc)2 and Ph3P, in the presence of an alcohol (R"OH) or water (R"=H) and a base, e.g., triethylamine, in a suitable solvent such as DMF, to produce the olefinic ester or acid of the formula: The olefin can then be subsequently asymmetrically hydrogenated, as described below, to produce a trisubstituted succinic acid derivative of the formula: If R" is not H, R" can be removed by either hydrolysis, acidolysis, or hydrogenolysis, to afford the corresponding acid, which is then coupled to the sulfamate isostere as described above and then, optionally, the R group removed to produce the corresponding acid, and optionally, converted to the amide. Alternatively, one can react the sulfamate isostere with either a suitably monoprotected succinic acid or glutaric acid of the following structure; followed by removal of the protecting group and conversion of the resulting acid to an amide. One can also react an anhydride of the following structure; with the sulfamate isostere and then separate any isomers or convert the resulting acid to an amide and then separate any isomers. It is contemplated that for preparing compounds of the Formulas having R6, the compounds can be prepared following the procedure set forth above and, prior to coupling the sulfamate derivative or analog thereof, e.g. coupling to the amino acid PNH(CH2) tCH(Rl)COOH, carried through a procedure referred to in the art as reductive amination. Thus, a sodium cyanoborohydride and an appropriate aldehyde or ketone can be reacted with the sulfamate derivative compound or appropriate analog at room temperature in order to reductively aminate any of the compounds of Formulas I-IV. It is also contemplated that where R of the amino alcohol intermediate is hydrogen, the inhibitor compounds of the present invention wherein R is alkyl, or other substituents wherein the -C contains at least one hydrogen, can be prepared through reductive amination of the final product of the reaction between the amino alcohol and the amine or at any other stage of the synthesis for preparing the inhibitor compounds. Contemplated equivalents of the general formulas set forth above for the antiviral compounds and derivatives as well as the intermediates are compounds otherwise corresponding thereto and having the same general properties, such as tautomers thereof as well as compounds, wherein one or more of the various R groups are simple variations of the substituents as defined therein, e.g., wherein R is a higher alkyl group than that indicated. In addition, where a substituent is designated as, or can be, a hydrogen, the exact chemical nature of a substituent which is other than hydrogen at that position, e.g., a hydrocarbyl radical or a halogen, hydroxy, amino and the like functional group, is not critical so long as it does not adversely affect the overall activity and/or synthesis procedure. The chemical reactions described above are generally disclosed in terms of their broadest application to the preparation of the compounds of thiε invention. Occasionally, the reactions may not be applicable aε deεcribed to each compound included within the diεcloεed scope. The compounds for which this occurs will ' be readily recognized by those εkilled in the art. In all such cases, either the reactions can be successfully performed by conventional modifications known to those skilled in the art, e.g., by appropriate protection of interfering groups, by changing to alternative conventional reagents, by routine modification of reaction conditions, and the like, or other reactions disclosed herein or otherwise conventional, will be applicable to the preparation of the corresponding compounds of this invention. In all preparative methods, all starting materials are known or readily preparable from known starting materials. Without further elaboration, it is believed that one skilled in the art can, uεing the preceding description, utilize the present invention cc its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever. All reagents were used as received without purification. All proton and carbon NMR spectra were obtained on either a Varian VXR-300 or VXR-400 nuclear magnetic resonance spectrometer. The following Examples 1 through 9 illustrate preparation of intermediateε. Theεe intermediateε are useful in preparing the inhibitor compounds of the present invention as illustrated in Examples 13-17. In addition, the intermediates of Examples 4-9 are also retroviral protease inhibitors and inhibit, in particular, HIV proteaεe. Example 1 Preparation of Nf3 (S) -benzyloxycarbonylamino-2 (R) hvdroxy-4-phenylbutyll -N-iεoamylamine Part A: To a εolution of 75.Og (0.226 mol) of N-benzyloxycarbonyl-L-phenylalanine chloromethyl ketone in a mixture of 807 mL of methanol and 807 mL of tetrahydrofuran at -2°C, was added 13.17g (0.348 mol, 1.54 equiv.) of solid sodium borohydride over one hundred minuteε. The εolventε were removed under reαuced pressure at 40°C and the residue dissolved in ethyl acetate (approx. ID . The solution waε washed εequentially with IM potaεεium hydrogen εulfate, εaturated εodium bicarbonate and then εaturated εodium chloride solutions. After drying over anhydrous magneεium sulfate and filtering, the solution waε removed under reduced preεsure. To the resulting oil waε added hexane (approx. ID and the mixture warmed to 60°C with swirling. After cooling to room temperature, the solidε were collected and washed with 2L of hexane. The resulting εolid was recrystallized from hot ethyl acetate and hexane to afford 32.3g (43% yield) of N-benzyloxycarbonyl-3 (S) -amino-l-chloro-4-phenyl-2 (S) - butanol, mp 150-151°C and M+Li+ = 340. Part B: To a solution of 6.52g (0.116 mol, 1.2 equiv.) of potassium hydroxide in 968 mL of absolute ethanol at room temperature, waε added 32.3g (0.097 mol) of N-CBZ- 3 (S) -amino-l-chloro-4-phenyl-2 (S) -butanol. After stirring for fifteen minutes, the solvent was removed under reduced preεεure and the εolidε dissolved in methylene chloride. After washing with water, drying over magnesium sulfate, filtering and stripping, one obtains 27.9g of a white solid. Recrystallization from hot ethyl acetate and hexane afforded 22. ?g (77% yield) of N-benzyloxycarbonyl-3 (S) -amino-1,2 (S) -epoxy-4- phenylbutane, mp 102-103°C and MH+ 298. Part C: A solution of N-benzyloxycarbonyl 3(S)-amino- 1,2- (S) -epoxy-4-phenylbutane (l.OOg, 3.36 mmol) and isoamylamine (4.90g, 67.2 mmol, 20 equiv.) in 10 mL of isopropyl alcohol was heated to reflux for 1.5 hours. The εolution waε cooled to room temperature, concentrated in vacuo and then poured into 100 mL of εtirring hexane whereupon the product crystallized from solution. The product waε iεolated by filtration and air dried to give 1.18g, 95% of N= [ [3 (S) -phenylmethylcarbamoyl) amino-2 (R) - hydroxy-4-phenyIbuty1]N- [ (3-methylbuty1) ] anime mp 108.0-109.5°C, MH+ m/z = 371. Example 2 Preparation of N,N-dibenzyl-3 (S) -amino-1, 2- (S) -epoxy-4- phenylbutane A εolution of L-phenylalanine (50.0 g, 0.302 mol) , sodium hydroxide (24.2 g, 0.605 mol) and potasεiu carbonate (83.6 g, 0.605 mol) in water (500 ml) iε heated to 97°C. Benzyl bromide (108.5 ml, 0.912 mol) iε then slowly added (addition time -25 min) . The mixture is then εtirred at 97°C for 30 minuteε. The solution is cooled to room temperature and extracted with toluene (2 x 250 ml) . The combined organic layers are then washed with water, brine, dried over magnesium εulfate, filtered and concentrated to give an oil product. The crude product iε then uεed in the next εtep without purification. S p B: The crude benzylated product of the above step is diεsolved in toluene (750 ml) and cooled to -55°C. A 1.5 M solution of DIBAL-H in toluene (443.9 ml, 0.666 mol) is then added at a rate to maintain the temperature between -55° to -50°C (addition time - 1 hour) . The mixture iε εtirred for 20 minuteε at -55°C. The reaction is quenched at -55°C by the slow addition of methanol (37 ml) . The cold εolution iε then poured into cold (5°C) 1.5 N HC1 εolution (1.8 L) . The precipitated solid (approx. 138 g) is filtered off and washed with toluene. The εolid material is suspended in a mixture of toluene (400 ml) and water (100 ml) . The mixture is cooled to 5°C, treated with 2.5 N NaOH (186 ml) and then stirred at room temperature until the solid is dissolved. The toluene layer is εeparated from the aqueous phaεe and waεhed with water and brine, dried over magneεium sulfate, filtered and concentrated to a volume of 75 ml (89 g) . Ethyl acetate (25 ml) and hexane i25 ml) are then added to the residue upon which the alcohol product begins to crystallize. After 30 min., an additional 50 ml hexane is added to promote further crystallization. The εolid iε filtered off and waεhed with 50 ml hexane to give approximately 35 g of material. A εecond crop of matrial can be isolated by refiltering the n-υtner liquor. The solidε are combined and recrystallized from ethyl acetate (20 ml) and hexane (30 ml) to give, in 2 crops, approximately 40 g (40% from L-phenylalanine) of analytically pure alcohol product. The mother liquors are combined and concentrated (34 g) . The residue is treated with ethyl acetate and hexane which provides an additional 7 g (-7% yield) of slightly impure solid product. Further optimization in the recovery from the mother liquor iε probable. Step C: A solution of oxalyl chloride (ft.4 ml, 0.096 mol) in dichloromethane (240 ml) is cooled co -74°C. A solution of DMSO (12.0 ml, 0.155 mol) in dichloromethane (50 ml) is then slowly added at a rate to maintain the temperature at -74°C (addition time -1.25 hr) . The mixture is stirred for 5 min. followed by addition of a solution of the alcohol (0.074 mol) in 100 ml of dichloromethane (addition time -20 min. , temp. -75°C to -68°C) . The solution is stirred at -78°C for 35 minutes. Triethylamine (41.2 ml, 0.295 mol) is then added over 10 min. (temp. -78° to -68°C) upon which the ammonium salt precipitated. The cold mixture is stirred for 30 min. and then water (225 ml) is added. The dichloromethane layer is separated from the aqueous phaεe and washed with water, brine, dried over magnesium sulfate, filtered and concentrated. The residue is diluted with ethyl acetate and hexane and then filtered to further remove the ammonium salt. The filtrate is concentrated to give the desired aldehyde product. The aldehyde was carried on to the next step without purification. Temperatures higher than -70°C have been reported in the literature for the Swern oxidation. Other Swern modifications and alternativeε to the Swern oxidations are also possible. A solution of the crude aldehyde 0.074 mol and chloroiodomethane (7.0 ml, 0.096 mol) in tetrahydrofuran (285 ml) is cooled to -78°C. A 1.6 M solution of n-butyllithium in hexane (25 ml, 0.040 mol) is then added at a rate to maintain the temperature at -75°C (addition time - 15 min.) . After the first addition, additional chloroiodomethane (1.6 ml, 0.022 mol) is added again, followed by n-butyllithium (23 ml, 0.037 mol), keeping the temperature at -75°C. The mixture iε stirred for 15 min. Each of the reagents, chloroiodomethane (0.70 ml, 0.010 mol) and n-butyllithium (5 ml, 0.008 mol) are added 4 more times over 45 min. at -75°C. The cooling bath iε then removed and the solution warmed to 22°C over 1.5 hr. The mixture is poured into 300 ml of saturated aq. ammonium chloride solution. The tetrahydrofuran layer is separated. The aqueous phaεe iε extracted with ethyl acetate (1 x 300 ml) . The combined organic layerε are waεhed with brine, dried over magnesium sulfate, filtered and concentrated to give a b rown oil (27.4 g) . The product could be uεed in the next step without purification. The desired diastereomer can be purified by recryεtallization at a subsequent step. Alternately, the product could be purified by chromatography. Example 3 Preparation of Nf3 (S) -benzyloxycarbonylamino-2 (R) -hvdroxy-4* phenyl1N-isobutylamine A εolution of N-benzyloxycarbonyl-3 (S) -amino- 1,2- (S) -epoxy-4-phenyl butane (50.0 g, 0.1o8 mol) and iεobutylamine (246 g, 3.24 mol, 20 equivalentε) in 650 mL of iεopropyl alcohol was heated to reflux tor 1.25 hours. The solution was cooled to room temperature, concentrated in vacuo and then poured into 1 L of stirring hexane whereupon the product crystallized from solution. The product waε isolated by filtration and air dried to give 57.56 g, 92% of N[3 (S) -benzyloxycarbonylamino-2 (R) - hydroxy-4-phenyl]N-iεobutylamine, mp 108.0-109.5 "C, MH+ m/z=371. Example 4 Preparation of phenylmethyl r2R-hvdroxy-3- r Γ (dimethylamino) sulfonyll (2-methylpropyl)amino1 -IS- (phenylmethyl)propyll carbamate The product from Example 3 (740 mg, 2.0 mmol) and diiεopropylethylamine (382 uL, 2.2 mmol) were diεεolved in dichloromethane (1.5 mL) at room temperature. To thiε was added dimethylsulfamoyl chloride (354 uL, 3.3 mmol) . The reaction waε stirred for 24 hours. The reaction mixture was chromatographed on silica gel (50 gm) using 1% ethanol in chloroform. The product fractions were pooled and concentrated to an oil. Anal. Calcd for ' '..H_J r _N.,5O c DS : C, 60.35; H, 7.39; Ν, 8.80. Found: C, 60.18; H, 7.40; Ν, 8.55. Example 5 Preparation of phenylmethyl [2R-hvdroxy-3- r Γ (dimethylamino) εulfonyll (3-methylbutyl) aminol -1S- (phenylmethyl)propyl1 carbamate Part A The procedure deεcribed in Example 1 waε uεed to prepare N[3 (S) -benzyloxycarbonylamino-2 (R) hydroxy-4- phenylbutyl] -N- [ (3-methylbutyl) ]amine. Part B The product from Part A (192 mg, 1.5 mmol) and diiεopropylethylamine (96 uL, 0.55 mmol) were dissolved in dichloromethane (10 mL) at room temperature. To this was added dimethylsulfamoyl chloride (59 uL, 0.55 mmol) . The reaction waε stirred for 120 hours, then concentrated on a rotary evaporator. The reεidue waε chromatographed on εilica gel (50 gm) using 2% methanol in dichloromethane. The product fractions were pooled and concentrated to an oil which solidified on standing. Anal. Calcd for C 25 H 37 N 3 0 ς S. 0.9 H 2 0: C, 59.13; H, 7.64; N, 8.27; S, 6...1. Found: C, 58.81; H, 7.38; N, 8.62; S, 6.70. Example 6 Preparation of phenylmethyl T3-f f (butylamino)sulfonyll (2- methylpropyl)amino1-2R-hvdroxy-lS- (phenylmethyl)propyll carbamate Part A: To a stirred solution of 3.88 gm (2 mL) of 30% fuming sulfuric acid in nitromethane (lOmL) was added dropwiεe n-butylisocyanate (3.83 mL, 34 mmoles) at 0 C. After the addition waε completed, the εuεpenεion was heated in an oil bath at 120 C. for 30 min. The reaction was cooled and filtered. The collected suifamic acid crystals were air dried, wt. 4.73 gm (91%). Part B: A suspension of n-butyl suifamic acid (1.92 gm, 12.53 mmoles) and phosphoruε pentachloride (2.61 gm, 12.53 mmoleε) in benzene (20 mL) waε warmed gently to initiate gaε evolution. The reaction mixture waε εtirred at room temperature for 0.5 h. , during which time a cloudy solution resulted.The cloudy εolution waε heated to reflux for 0.5 h., then waε concentrated. The product n-butyl εulfamoyl chloride waε isolated by vacuum distillation (120 C, 300 millitorr), 730 mg (liq.) (34%). Part C : The amino alcohol from Example 3 (370 mg, 1 mmole) was diεεolved in 3 mL of dichloromethane and treated with diisopropylethylamme (278 uL, 2 mmoles) , followed by chlorotrimethylsilane (126 uL, 1 mmole) . The reaction mixture was εtirred at r.t. for 1 h. n-Butyl sulfamoyl chloride from Part C (171 mg, 1 mmole) was added and the mixture was stirred at r.t. overnight. After removal of dichloromethane the oily reεidue waε taken up in ethyl acetate and waεhed εucceεεively with 5% citric acid, εaturated sodium bicarbonate, brine, dried over sodium εulfate and the solvent was evaporated to give 512 mg of product (oil) . The oily product (510 mg) was dissolved in dichloromethane (3 mL) and was treated with 2 mL of 4N HCl in dioxane. After 15 min. methanol (5 mL) was added and the solution was stirred for an additional 15 min. Solvent and excess reagent were evaporated. The product was isolated by silica gel chromatography to give 357 mg of phenylmethyl [3- [ [ (butylamino) sulfonyl] (2-methyIpropyl)amino] -2R-hydroxy-lS- (phenylmethyl)propyl] carbamate. Anal. Calcd for C26H39N3O5S: C, 61.76; H,7.77; N,8.31. Found: C, 61.89; H,7.66; N, 8.18. Example 7 Preparation of phenylmethyl r2R-hvdroxy-3- \ (4-methyl-1- pjperazinyl) sulfonyll (2-methylpropyl)amino1 -1S- (phenylmethyl)propyl1 carbamate Part A: 1-methylpiperazine hydrochlorid. (3.46 gm, 20 mmoleε) was added in portions within 15 min. to a stirred solution of sulfuryl chloride (8.99 gm, 67 mmoles) in acetonitrile(40 mL) . The suεpension was gradually warmed to reflux and maintained at reflux temperature overnight. A brown solution was obtained. After cooling to r.t., the crystals were collected by filtration, wt. 2.3 gm. A sample of 4-methyl-l-piperazine sulfamoyl chloride.HCl was recrystallized from methanol. Anal. Calcd. for C5H12N2O2CI2S: C, 25.54; H, 5.14; N, 11.91; Cl, 30.16. Found: C, 25.54; H, 4.91; N, 11.91; Cl, 29.88. Part B: N[3 (S) -benzyloxycarbonylamino-2 (R) -hydroxy-4- phenylbutyl] -N-iεobutylamine (370 mg, 1.0 mmole), prepared according to the procedure in Example 3 was mixed with DIEA (280 uL, 2.0 mmoles) and 4-methyl-l-piperazine sulfamoyl chloride.HCl (240 mg, 1.0 mmole) in 6 mL of dichloromethane. The reaction mixture was εtirred for 5 days. After filtration, the filtrate was concentrated to an oil, which was taken up in ethyl acetate. The ethyl acetate solution was washed with sodium bicarbonate solution, brine and dried over sodium sulfate. After evaporation, phenylmethyl [2R- hydroxy-3-[[ (4-methyl-l-piperazinyl) sulfonyl] (2- methyIpropyl)amino] -IS- (phenylmethyl)propyl ] carbamate was obtained (412 mg) . Example 8 Preparation of phenylmethyl [2R-hvdroxy-3- \ \ (1, 1- dimethyl)amino1 sulfonyll (2-methylpropyl)amino1 -1S- (phenylmethyl)propyll carbamate Part A: A 25 mL two-necked RB flask, equipped with a reflux condenser and dropping funnel and under a nitrogen atmosphere, was charged with t-butanol (207 uL, 2.2 mmoleε) and 5 mL of hexane. Chlorosulfonyl isocyanate (192 uL, 2.2 mmoles) in 3 mL of hexane was added dropwise. Upon warming a homogeneouε solution was obtained. The solution was heated at gentle reflux for 45 min. , then was cooled to r.t. Solvent was removed under a steady stream of nitrogen. The crude t-butyl εulfamoyl chloride (a liαuid) was used without further purification. Part B: N[3 (S) -benzyloxycarbonylamino-2 (R) -hydroxy-4- phenylbutyl] -N-iεobutylamine (370 mg, 1.0 mmole), prepared according to the procedure in Example 3 was mixed with DIEA (139 uL, 1 mmole) in 5 mL of dichloromethane. Chlorotrimethylεilane (126 uL, 1 mmole) waε added. After 1 h., additional DIEA (160 uL) waε added, fo lowed by a dichloromethane εolution (5mL) containing 1.1 mmole of t-butyl εulfamoyl chloride from Part A. The reaction mixture was stirred for 2 dayε. Solvent was removed under aspirator pressure. The oily residue was taken up in ethyl acetate and waεhed with 5% citric acid, εaturated sodium bicarbonate, brine, dried over sodium εulfate and evaporated to an oily residue (380 mg) . The crude product was stirred in 4N HCl in dioxane (6 mL) for 15 min. After the addition of 4 mL of methanol to the reaction mixture, the solucion waε εtirred for an additional 15 min, then concentrated to an oily residue. The product, phenylmethyl [2R-hydroxy -3- [[(1,1- dimethylethyl)amino] ulfonyl] (2-methyIpropyl)amino] -1S- (phenylmethyl)propyl] carbamate was obtained after silica gel chromatography (188 mg, 37%) . MS ( MH) + = 506. Part C: The carbobenzyloxy protecting group of the product from Part B was removed by hydrogenolysis. Thus 1.3 gramε of the product of Part B in 50 mL of methanol waε hydrogenated under 50 pεig of hydrogen using 0.7 g of 10% palladium-on-carbon catalyst 18 hourε. The catalyεt waε removed by filtration and the εolvent removed in vacuo to afford 0.75 g of the free amine. Example 9 Phenylmethyl [2R-hydroxy-3- [ [ (piperidyl) εulfonyl] (2- methyIpropyl)amino] -IS- (phenylmethyl)propyl] carbamate Part A: The product of Example 3 (750 mg, 2.02 mmol) and triethylamine (280 uL, 2.02 mmol) were dissolved in dichloromethane (8.0 mL) at room temperature. To this waε add piperidinesulfamoyl chloride (371 mg, 2.02 mmol) . The reactio was stirred for 72 hours and then concentrated. The residue w chromatographed on silica gel (50 gm) using 5% methanol in dichloromethane. The product fractionε were pooled and concentrated to an oil, 945 mg. TLC (silica / 5% MeOH in CH2C12) showed two spots. Rechromatographed. Anal. Calcd fo C27H39N305S: C, 62.63; H, 7.51; N, 8.06. Found: C, 62.64; H, 7.59; N, 8.12. Part B: The product of Part A (430 mg) was combined with 10% Pd/C in methanol (10 mL) and hydrogenated at 5 psi for 1.4 hou at room temperature. The catalyst was removed by filtration a the solvent evaporated to afford the product aε an oil, 305 mg. Part C: To a εolution of Cbz-L-t-leucine (236 mg, 0.89 mmol) in DMF (2 mL) waε added HOBt (115 mg, 0.85 mmol) and EDC (163 mg, 0.85 mmol) . The reaction waε εtirred e.t room temperature for 1 hour and then a solution of the product from part B (305 mg, 0.79 mmol) in DMF (2 mL) was added. The reaction was stirred for 18 hours then concentrated. The residue was taken up in ethyl acetate and washed with 0.5% HCl εolution, saturat aqueous NaHC03 , and εaturated aqueouε NaCl (50 mL each) . The organic solution was dried (Na2S04) , filtered and concentrated to a foam, 410 mg. IH NMR supports product. Part D: The product of Part C (410 mg) was combined with 10% Pd/C in methanol (10 mL) and hydrogenated at 5 pεi for 2.0 hou at room temperature. The catalyst was removed by filtration a the εolvent evaporated to afford the product aε an foam, 320 m Part E: To a εolution of the product of Part D (310 mg, 0.62 mmol) in dichloromethane (10 mL) waε added diisopropylethylam (130 uL, 0.75 mmol) and chloroacetic anhydride (117 mg, 0.68 mmol) at 0 C. The reaction was allowed to warm to room temperature and stir one hour. The solvent was removed and th residue taken up in ethyl acetate (50 mL) . The organic soluti was washed with 5% citric acid, saturated NaHC03 , and saturate NaCl (50 mL each) . The solution was dried (Na2S04) , filtered and concentrated to give a solid, 350 mg. Part F: The product of Part E (350 mg, 0.61 mmol) waε combined with 40% aqueouε dimethylamine (380 uL, 3.05 mmol) in iεopropanol (10 mL) . The reaction waε stirred for 18 hours th concentrated. The residue was taken up in ethyl acetate (50 m and washed with water, saturated NaHC03 , and saturated NaCl (5 mL each) . The solution was dried (Na2S04) , filtered and concentrated to a solid. The solid was chromatographed on silica gel using 2% MeOH in dichloromethane. The product fractions were pooled and concentrated to give a white solid. Anal. Calcd for C29H51N505S. 0.25 H20: C, 59.41; H, 8.77; N, 11.94. Found: C, 59.35; H, 8.78; N, 11.63. Example 10 Following the procedures of the previous Examples 1-9, the intermediate compoundε εet forth in Tables IA, IB and IC were prepared. TABLE IA isobutyl CH- CH„ isoamyl CH- CH-, isobutyl CH2CH2CH2CH3 H TABLE IB Entr Σ. R4 1 CH, CH. 2 3 4 5 6 7 o N N-CH, D isobutyl NR 4 R 5 isobutyl phenyl H G H H I H J H K H L M H The following Examples 11-14 illustrate preparation of succinoyl compounds. These intermediates can be coupled to the intermediate compounds of Examples 1-10 to produce inhibitor compounds of the present invention. Preparation of Benzyl 2 , 2 , 3 (R) -trimethylsuccinate PART A: Preparation of Methyl (S) -lactate, 2-methoxy-2- propyl ether. To a mixture of methyl (S) -(-) -lactate (13.2g, 100 mmol) and, 2-methoxypropene (21.6g, 300 mmol) in CH2CI2 (150 ml) was added POCI3 (7 dropε) at r.t. and the resulting mixture was εtirred at this temperature for 16 hourε. After the addition of Et3N (10 drops), the solvents were removed in vacuo to give 20. Og of (98%) desired product. PART B: Preparation of 2 (S) -hydroxypropanal, 2-methoxy- 2-propyl ether. O To a solution of compound from Part A (20.Og) in CH2CI2 (100 ml) was added DIBAL (65 ml of 1.5M solution in toluene, 97.5 mmol) dropwiεe at -78°C for 45 min. , then stirring was continued at this temperature for another 45 min. To this cold solution was added MeOH (20 ml), saturated NaCl εolution (10 ml) and allowed the reaction mixture to warm up to r.t. and diluted with ether (200 ml), MgS04 (150g) waε added and stirred for another 2 h. The mixture was filtered and the solid was washed twice with ether. The combined filtrates were rotavaped to afford 11.2g (78%) of the deεired aldehyde. PART C: Preparation of 2 (S) -hydroxy-ciε-3-butene, 2-methoxy-2-propyl ether. To a εuεpenεion of ethyltriphenylphoεphonium bromide (28g, 75.5 mmol) in THF (125 ml) αt. added KN (TMS) 2 (15.7g, 95%, 75 mmol) in portionε at 0°C and εtirred for 1 h at the temperature. Thiε red reaction mixture was cooled to -78°C and to this was added a solution of aldehyde from Part B dig, 75 mmol) in THF (25 ml) . After the addition was completed, the resulting reaction mixture was allowed to warm up to r.t. and stirred for 16 h. To thiε mixture was added saturated NH4CI (7.5 ml) and filtered through a pad of celite with a thin layer of silica gel on the top. The solid was washed twice with ether. The combined filtrates were concentrated in vacuo to afford 11.5g of crude product. The purification of crude product by flash chromatography (silica gel, 10:1 Hexanes/EtoAc) affording 8.2g (69%) pure alkene. PART D : Preparation of 2 ( S ) -hydroxy-cis-3 -butene . A mixture of alkene from Part C (8.2g) and 30% aqueouε acetic acid (25 ml) was stirred at r.t. for 1 hour. To thiε mixture was added NaHC03 slowly until the pH was - 7, then extracted with ether (10 ml x 5) . The combined ether solutions were dried ( a2S04) and filtered. The filtrate was distilled to remove the ether to give 2.85g (64%) pure alcohol, m/e=87 (M+H) . PART E: Preparation of 2,2, 3-trimethyl-hex- (trans) -4- enoic acid. To a mixture of alcohol from Part D (2.5g, 29 mmol) and pyridine (2.5 ml) in CH2CI2 (60 ml) was added iεobutyryl chloride (3.1g, 29 mmol) εlowly at 0°C. The resulting mixture was stirred at r.t. for 2 hourε then waεhed with H20 (30 ml x 2) and sat. NaCl (25 ml) . The combined organic phases were dried (Na2S04), concentrated to afford 4.2g (93%) ester 2 (S) -hydroxy-cis-3-butenyl isobutyrate. This ester was diεεolved in THF (10 ml) and waε added to a 1.0M LDA εoln. (13.5 ml of 2.**V*. LDA εolution in THF and 13.5 ml of THF) slowly at -78°C. The resulting mixture was allowed to warm up to r.t. and stirred for 2 h and diluted with 5% NaOH (40 ml) . The organic phase was separated, the aqueous phase was washed with Et2θ (10 ml) . The aqueous solution was collected and acidified with 6N HCl to pH - 3. The mixture was extracted with ether (30 ml x 3) . The combined ether layers were washed with sat. NaCl (25 ml), dried (Na2S04) and concentrated to afford 2.5g (60%) of desired acid, m/e=157 (M+H) . PART F: Preparation of benzyl 2,2,3 (S ) -tr methyl-tranε- 4-hexenoate. A mixture of acid from Part E (2.5g, 16 mmol), BnBr (2.7g, 15.8 mmol), K2CO3 (2.2g, 16 mmol) , Nal (2.4gl in acetone (20 ml) waε heated at 75°C (oil bath) for 16 h. The acetone waε εtripped off and the reεidue waε diεεolved in H2O (25 ml) and ether (35 ml) . The ether layer waε εeparated, dried (Na2S04) and concentrated to afford 3.7g (95%) of benzyl eεter, m/e=247 (M+H) . PART G: Preparation of benzyl 2,2,3 (R) - trimethylεuccinate. To a well-εtirred mixture of KMnθ4 (5.4g, 34, 2 mmol), H20 (34 ml), CH2CI2 (6 ml) and benzyltriethylammonium chloride (200 mg) waε added a solution of ester from Part F (2.1g, 8.54 mmol) and acetic acid (6 ml) in CH2CI2 (28 ml) slowly at 0°C. The resulting mixture was stirred at the temperature for 2 h then r.t. for 16 h. The mixture was cooled in an ice- water bath, to this waε added 6N HCl (3 ml) and εolid NaHS03 in portions until the red color disappeared. The clear solution waε extracted with CH2CI2 (30 ml x 3) . The combined extractε were washed with sat. NaCl solution, dried (Na2S04) and concentrated to give an oil. This oil was dissolved in Et2θ (50 ml) and to this was added sat. NaHC03 (50 ml) . The aqueous layer was separated and acidified with βN HCl to pH - then extracted with Et2θ (30 ml x 3) . The combined extracts were washed with sat. NaCl solution (15 ml), dried (Na2S04) and concentrated to afford 725 mg (34%) of desired acid, benzyl 2,2,3 (R) -trimethylsuccinate, m/e=251(M+H) . Preparation of methyl 2.2-dimethyl-3-methyl s ccinate, (R) and (S) isomers. PART A: Preparation of methyl 2, 2-dimethyl-3-oxo- butanoate. A 250 ml RB flaεk equipped with magnetic stir bar and N2 inlet was charged with 100 ml dry THF and 4.57g (180 mmol) of 95% NaH. The slurry was cooled to -20°C and lOg (87 mmol) methyl acetoacetate was added dropwise followed by 11.3 ml (181 mmol) CH3I. The reaction was stirred at 0°C for 2 hours and let cool to room temperature overnight. The reaction was filtered to remove Nal and diluted with 125 ml Et20. The organic phase was washed with 1x100 1 5% brine, dried and concentrated in vacuo to a dark golden oil that was filtered through a 30g plug of silica gel with hexane. Concentration in vacuo yielded 10.05g of desired methyl ester, as a pale yellow oil, suitable for use without further purification. PART B: Preparation of methyl 2, 2-dimethyl-3-0- (trifluoromethaneεulfonate) -but-3-enoate. A 250 ml RB flask equipped with magnetic stir bar and N2 inlet was charged with 80 mL by THF and 5.25 ml (37.5 mmol) diisopropylamine waε added. The εolution was cooled to -25°C (dry ice/ethylene glycol) and 15 ml (37.5 mmol) of 2.5 M n-BuLi in hexanes was added. After 10 minutes a solution of 5g (35 mmol) 1 in 8 ml dry THF was added. The deep yellow solution was stirred at -20°C for 10 min. then 12.4g N-phenyl bis (trifluoromethane- εulfonimide) (35 mmol) waε added. The reaction waε εtirred @ -10°C for 2 hourε, concentrated in vacuo and partioned between ethyl acetate and sat. NaHCθ3. The combined organic phase was washed with NaHC03 , brine and cone, to an amber oil that was filtered through a 60g silica gel plug with 300 mL 5% ethyl acetate/hexane. Cone, in vacuo yielded 9. Og light yellow oil that was diluted with 65 ml ethyl acetate and washed with 2x50 ml 5% aq K2CO3, 1x10 mL brine, dried over Na2≤04 and cone. in vacuo to yield 7.5g (87%) vinyl triflate, (m/e=277 (M+H) suitable for uεe without further purification. PART C: Preparation of methyl 2, 2-dimethyl-3-carboxy1- but-3-enoate. A 250 ml Fisher Porter bottle was charged with 7.5g (27 mmol) of compound prepared in B, 50 ml dry DMF, 360 mg (1.37 mmol) triphenyl phosphine and 155 mg (.69 mmol) Pd(II) (OAc)2- The reaction mixture was purged twice with N2 then charged with 30 psi CO. Meanwhile a solution of 20 ml dry DMF and 7.56 ml (54 mmol) NEt3 was cooled to 0°C to this was added 2.0g (43 mmol) of 99% formic acid. The mixture was swirled and added to the vented Fisher Porter tube. The reaction vessel was recharged to 40 psi of CO and stirred 6 hours @ room temperature. The reaction mixture was concentrated in vacuo and partioned between 100 mL of ethyl acetate and 75 mL 5% aq K2CO3. The aqueous phase was washed with 1x40 mL additional ethyl acetate and then acidified with cone. HCl/ice. The aqueouε phaεe waε extracted with 2x70 mL of ethyl acetate and the organics were dried and cone. to yield 3.5g (75%) white crystals, mp 72-75°C, identified as the desired product (m/e=173 (M+H) . PART D: Preparation of methyl 2, 2-dimethyl-3- methylsuccinate, isomer #1. A εteel hydrogenation veεsel was charged with 510 mg (3.0 mmol) acrylic acid, from Part C, and 6 mg Ru (acac)2 (R-BINAP) in 10 ml degaεεed MeOH. The reaction waε hydrogenated at 50 pεi/roo temperature for 12 hourε. The reaction was then filtered through celite and cone, to 500 mg clear oil which waε εhown to be a 93:7 mixture of iεomer #1 and #2, reεpectively aε determined by GC analyεiε uεing a 50 M β-cyclodextrin column: 150°C - 15 min. then ramp 2°C/min.; iεomer #1, 17.85 min., isomer #2, 18-20 min. PART E: Preparation of methyl 2, 2-dimethyl-3- methylεuccinate, Isomer #2. A steel hydrogenation vessel was charged with 500 mg (2.9 mmol) acrylic acid, Part C, and 6 mg Ru(OAc) (acac) (S-BINAP) in 10 ml degasεed MeOH. The reaction waε hydrogenated at 50 psi/room temperature for 10 hours. The reaction was filtered through celite and concentrated in vacuo to yield 490 mg of product as a 1:99 mixture of isomers #1 and #2, respectively, as determined by chiral GC as above. In a similiar manner, one can uε*= benzyl 2,2- dimethyl-3-oxo-butanoate to prepare benzyl 2,2,3- trimethylsuccinate, R and S iεomerε. Other methodε for preparing succinic acids, succinateε and succinamides are well known in the art and can be utilized in the present invention. Example 13 Following the procedure generally as set forth in Examples 11 and 12, or utilizing procedures known in the art, the compounds shown in Tables 2 and 3 could be prepared. TABLE 2 Rl R30 R31 R32 x' R 33 R 34 H H H TABLE 2 (Cont'd.) R1 R 30 R31 R 32 χ . R 33 R 34 TABLE 3 Example 14 Preparation of r (4-phenyl)methyl14- 13 - \ \ \ \ ( 1 .1- dimethylethyl)amino] sulfonyll (2-methyIpropyl)amino] -2R- hvdroxy-lS- (phenylmethyl)propyl1amino] -2,2, 3R-trimethvl- 4-oxobutanoate To a solution of 129 mg (0.52 mmol) 2(R),3,3- trimethylsuccinic acid benzyl ester in 1 mL of anhydrous N,N-dimethylformamide (DMF) and 119 mg (0.78 mmol) of N-hydroxybenzotriazole at 0'C, was added 110 mg (0.57 mmol) of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride. After two hours at 0"C, a solution of 175 mg (0.47 mmol) of free amine from Example 8, Part G in 0.5 mL of DMF was added, and the mixture stirred at room temperature for sixteen hours. Ethyl acetate was added, washed with 5% aqueous citric acid, saturated aqueous sodium bicarbonate and brine, dried over anhydrous magnesium sulfate, filtered and concentrated to afford 278 mg of crude product. This was chromatographed on silica gel using 10-20% ethyl acetate/hexane to yield 134 mg of material, which was further purified by chromatography on silica gel 60 silanized RP-2 (Merck) using 10-20% acetonitrile/water to afford 98 mg (16% yield) of the desired product, m/e = 605 (M + H) . Example 15 Preparation of 4- f3- r I \ ( 1.1-dimethylethyl) amino1 sulfonyl] (2-methylpropyl) aminol -2R-hvdroxy-lS- (phenylmethyl)propyll aminol -2.2.3R-trimethyl-4- oxobutanoic acid A solution of 98 mg (0.16 mmol) of benzyl ester from Example 14 in 10 mL of ethanol was hydroganaced under 50 psig of hydrogen in the presence of 111 mg of 10% palladium-on-carbon catalyst for one hour. After removal of the catalyst by filtration, the solution was concentrated to afford 83 mg (100% yield) of the desired product, m/e = 514 (M + H) . Example 16 Preparation of N4- [3- r \ \ \ (1 ■ 1-dimethylethyl) aminol - sulfonyl1 (2-methylpropyl) aminol -2R-hvdroxy-lS- (phenylmethyl) ropyl1-2,2, 3R-trimethylbutanediamide To a solution of the acid from Example 15 (49 mg, 0.094 mmol) and 29 mg (0.19 mmol) of N-hydroxybenzotriazole in 0.60 mL of anhydrous N,N-dimethylformamide at 0'C, was added 27 ;?.g (0.14 mmol) of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride. After two hours at 0'C, 5 mg (0.95 mmol) of 30% aqueous ammonia was added. After two days, ethyl acetate was added, washed with 5% aqueous citric acid, saturated sodium bicarbonate, brine, dried over anhydrous magnesium sulfate, filtered and concentrated to afford 42 mg of crude product. This was chromatographed on basic alumina using 1-2% methanol/methylene chloride to afford 16 mg (33%) of the desired product, m/e = 513 (M+H) . Utilizing the procedures set forth above, the compounds shown in Tables 4-14 could be prepared. Thus, utilizing the intermediates of Examples 1-13 according to the procedures in Example 14, the compounds shown in Tables 4-16 could be prepared. General methods for preparing such compounds are set forth below. General Procedure for the Synthesis of Ammo Epoxide PART A : To a solution of 0.226 mol of an N-benzyloxycarbonyl-L-amino acid chloromethyl ketone in a mixture of 807 mL of methanol and 807 mL of tetrahydrofuran at -2°C, is added 1.54 equiv. of solid sodium borohydride over one hundred minutes . The solvents are then removed under reduced pressure at 40°C and the residue is dissolved in ethyl acetate (approx. IL) . The solution is washed sequentially with IM potassium hydrogen sulfate, saturated sodium bicarbonate and is then saturated sodium chloride solutions . After drying over anhydrous magnesium sulfate and filtering, the solution is removed under reduced pressure. To the resulting oil is added hexane (approx. IL) and the mixture is warmed to 60°C with swirling. After cooling to room temperature, the solids are collected and washed with 2L of hexane. The resulting solid is recrystallized from hot ethyl acetate and hexane to afford 32.3g (43% yield) of N-benzyloxycarbonyl-3 (S) -amino-l-chloro-4- substituted-2 (S) -butanol, mp 150-151°C and M+Li+ = 340. PART B: To a solution of 1.2 equiv. of potassium hydroxide in 968 mL of absolute ethanol at. room temperature, is added 0.097 mol of N-CBZ- (S) -amino-1- chloro-4-phenyl-2 (S) -butanol . After stirring for fifteen minutes, the solvent is removed under reduced pressure and the solids are dissolved in methylene chloride. After washing with water, drying over magnesium sulfate, filtering and stripping, one obtains a white solid. Recrystallization from hot ethyl acetate and hexane will afford N-benzyloxycarbonyl-3 (S) -amino-1,2 (S) -epoxy-4- phenylbutane. Alternate General Procedure for the Synthesis of Amino Epoxides Step A: R R 2 ' A solution of an amino acid (50.0 g, 0.302 mol), sodium hydroxide (24.2 g, 0.605 mol) and potassium carbonate (83.6 g, 0.605 mol) in water (500 ml) is heated to 97°C. Benzyl bromide (108.5 ml, 0.912 mol) is then slowly added (addition time -25 min) . The mixture is then stirred at 97°C for 30 minutes. The solution is cooled to room temperature and extracted with toluene (2 x 250 ml) . The combined organic layers are then washed with water, brine, dried over magnesium sulfate, filtered and concentrated to give an oil product. The crude product is then used in the next step without purification. Step B: The crude benzylated product of the above step is dissolved in toluene (750 ml) and cooled to -55°C. A 1.5 M solution of DIBAL-H in toluene (443.9 ml, 0.666 mol) is then added at a rate to maintain the temperature between -55° to -50°C (addition time - 1 hour) . The mixture is stirred for 20 minutes at -55°C. The reaction is quenched at -55°C by the slow addition of methanol (37 ml) . The cold solution is then poured into cold (5°C) 1.5 N HCl solution (1.8 L) . The precipitated solid (approx. 138 g) is filtered off and washed with toluene. The solid material is suspended in a mixture of toluene (400 ml) and water (100 ml) . The mixture is cooled to 5°C, treated with 2.5 N NaOH (186 ml) and then stirred at room temperature until the solid is dissolved. The toluene layer is separated from the aqueous phase and washed with water and brine, dried over magnesium sulfate, filtered and concentrated to a volume of 75 ml (89 g) . Ethyl acetate (25 ml) and hexane (25 ml) are then added to the residue upon which the alcohol product begins to crystallize. After 30 min., an additional 50 ml hexane is added to promote further crystallization. The solid is filtered off and washed with 50 ml hexane to give approximately 35 g of material. A second crop of material can be isolated by refiltering the mother liquor. The solids are combined and recrystallized from ethyl acetate (20 ml) and hexane (30 ml) to give, in 2 crops, approximately 40 g (40% from L-phenylalanine) of analytically pure alcohol product. The mother liquors are combined and concentrated (34 g) . The residue is treated with ethyl acetate and hexane which provides an additional 7 g (-7% yield) of slightly impure solid product. Further optimization in the recovery from the mother liquor is probable. Step C: A solution of oxalyl chloride (8.4 ml, 0.096 mol) in dichloromethane (240 ml) is cooled to -74°C. A solution of DMSO (12.0 ml, 0.155 mol) in dichloromethane (50 ml) is then slowly added at a rate to maintain the temperature at -74°C (addition time -1.25 hr) . The mixture is stirred for 5 min. followed by addition of a solution of the alcohol (0.074 mol) in 100 ml of dichloromethane (addition time τ20 min., temp. -75°C to -68°C) . The solution is stirred at -78°C for 35 minutes. Triethylamine (41.2 ml, 0.295 mol) is then added over 10 min. (temp. -78° to -68°C) upon which the ammonium salt precipitated. The cold mixture is stirred for 30 min. and then water (225 ml) is added. The dichloromethane layer is separated from the aqueous phase and washed with water, brine, dried over magnesium sulfate, filtered and concentrated. The residue is diluted with ethyl acetate and hexane and then filtered to further remove the ammonium salt. The filtrate is concentrated to give the desired aldehyde product. The aldehyde was carried on to the next step without purification. Temperatures higher than -70°C have been reported in the literature for the Swern oxidation. Other Swern modifications and alternatives to the Swern oxidations are also possible. A solution of the crude aldehyde 0.074 mol and chloroiodomethane (7.0 ml, 0.096 mol) in tetrahydrofuran (285 ml) is cooled to -78°C. A 1.6 M solution of n-butyllithium in hexane (25 ml, 0.040 mol) is then added at a rate to maintain the temperature at -75°C (addition time - 15 min.) . After the first addition, additional chloroiodomethane (1.6 ml, 0.022 mol) is added again, followed by n-butyllithium (23 ml, 0.037 mol) , keeping the temperature at -75°C. The mixture is stirred for 15 min. Each of the reagents, chloroiodomethane (0.70 ml, 0.010 mol) and n-butyllithium (5 ml, 0.008 mol) are added 4 more times over 45 min. at -75°C. The cooling bath is then removed and the solution warmed to 22°C over 1.5 hr. The mixture is poured into 300 ml of saturated aq. ammonium chloride solution. The tetrahydrofuran layer is separated. The aqueous phase is extracted with ethyl acetate (1 x 300 ml) . The combined organic layers are washed with brine, dried over magnesium sulfate, filtered and concentrated to give a brown oil (27.4 g) . The product could be used in the next step without purification. The desired diastereomer can be purified by recrystallization at the subsequent sulfonamide formation step. Alternately, the product could be purified by chromatography. General Procedure for the Synthesis of 1.3-Diamino 4-phenyl Butan-2-ol Derivatives . A mixture of the amine R3NH2 (20 equiv.) in dry isopropyl alcohol (20mL/mmol of epoxide to be converted) is heated to reflux and then is treated with an N-Cbz amino epoxide of the formula: from a solids addition funnel over a 10-15 minute period. After the addition is complete the solution is maintained at reflux for an additional 15 minutes and the progress of the reaction monitored by TLC . The reaction mixture is then concentrated in vacuo to give an H "■ and is then treated with n-hexane with rapid stirring whereupon the ring opened-material precipitates from solution. Precipitation is generally complete within 1 hr and the product is then isolated by filtration on a Bύchner funnel and is then air dried. The product is further dried in vacuo. This method affords amino alcohols of sufficient purity for most purposes. General Procedure for Preparation of Sulfamoyl Chlorides To a solution of 547 mmol of sulfuryl chloride in 100 mL of anhydrous acetonitrile under a nitrogen atmosphere, was added 136 mmol of amine hydrochloride and the mixture heated to reflux for twenty-four to forty-eight hours. The solution was cooled and concentrated in vacuo to afford a semi-solid. Anhydrous diethyl ether was added, the solids removed by filtration and the filtrate concentrated to afford the crude sulfamoyl chloride. This can be used as is, or if desired, purified by either crystallization or distillation. General Procedure for the Reaction of Amino Alcohols with Sulfamoyl Halides: Preparation of Suifamic Acids To a solution of N[3(S)- benzyloxycarbonylamino-2 (R) -hydroxy-4-substituted] N-substitutedamine (0.5 mmol) and a suitable amine (0.5 mmol) in dichloromethane (10 mL) is added (0.5 mmol) of the sulfamoyl chloride. The reaction mixture is stirred until the reaction is substantially complete, such as for 120 hours at room temperature, then the dichloromethane solution is concentrated and applied to a silica gel column (50 gm) . The column is eluted with 2% methanol in dichloromethane, 1% ethanol and 1% methanol. General Procedure for the Removal of the Protecting Groups bv Hvdroσenolvsis with Palladium on Carbon A. Alcohol Solvent The Cbz-protected peptide derivative is dissolved in methanol (ca.20mL/mmol) and 10% palladium on carbon catalyst is added under a nitrogen atmosphere. The reaction vessel is sealed and flushed 5 times with nitrogen and then 5 times with hydrogen. The pressure is maintained at 50 psig for 1-16 hours and then the hydrogen is replaced with nitrogen and the solution is filtered through a pad of celite to remove the catalyst. The solvent is removed in vacuo to give the free amino derivative of suitable purity to be taken directly on to the next step. B. Acetic Acid Solvent The Cbz-protected peptide derivative is dissolved in glacial acetic acid (20mL/mm*-.] ) and 10% palladium on carbon catalyst is added under a nitrogen atmosphere. The reaction vessel is flushed 5 times with nitrogen and 5 times with hydrogen and then maintained at 40 psig for about 2h. The hydrogen is then replaced with nitrogen and the reaction mixture filtered through a pad of celite to remove the catalyst. The filtrate is concentrated and the resulting product is taken up in anhydrous ether and is evaporated to dryness 3 times. The final product, the acetate salt, is dried in vacuo and is of suitable purity for subsequent conversion. General Procedure for Removal of Boc-protectinσ Group with 4N Hydrochloric Acid in Dioxane The Boc-protected amino cr peptide is treated with a solution of 4N HCl in dioxane with stirring at room temperature. Generally the deprotection reaction is complete within 15 minutes, the progress of the reaction is monitored by thin layer chromatography (TLC) . Upon completion, the excess dioxane and HCl are removed by evaporation in vacuo . The last traces of dioxane and HCl are best removed by evaporation again from anhydrous ether or acetone. The hydrochloride salt thus obtained is thoroughly dried in vacuo and is suitable for further reaction. TABLE 4 Entry X R3 R4 TABLE 4 (Cont'd) Entry X R3 R4 TABLE 4 (Cont'd) TABLE 4 (Cont'd) Entry X R R4 TABLE 5 Entry R J 1 CH2SO2CH3 2 (R) -CH(OH)CH3 3 CH(CH3)2 4 (R,S)CH2SOCH3 5 CH2SO2 H2 6 CH2SCH3 7 CH2CH(CH3)2 8 CH2CH2C(0)NH2 9 (S)-CH(OH)CH3 10 — CH 2 C≡CH 11 -CH2CH3 12 -CH2C(0)NH2 TABLE 6 Entry R 2 1 n-Bu 10 2 cyclohexylmethyl 3 C6H5CH2 4 2-naphthylmethyl 5 p-F(C6H4)CH2 6 p-(PhCH20) (C6H4)CH2 15 7 p-H0(C6H4)CH2 TABLE 7 Entry R3 R4 TABLE 8 TABLE 9 TABLE 9 (Cont'd.) TABLE 10 N— R 4 R3 A. -CH2CH(CH3)2 -CH2CH(CH3)2 -CH2CH(CH3)2 -CH2CH2CH ( CH 3 )2 -CH2CH2CH(CH 3 )2 TABLE 10 (Cont'd.) N— R, R3 R 5 - TABLE 10 (Cont'd.) N— 4 R3 A. -CH2CH(CH 3 ) 2 O TABLE 11 N— R 4 R3 A. -CH2CH(CH3)2 -N(CH3)2 -CH2CH(CH3)2 -N(CH2CH3)2 -CH2CH(CH3)2 -N(CH(CH3)2)2 -CH2CH2CH ( CH3)2 -N ( CH3 ) 2 -CH2CH2CH(CH3)2 -N ( :CCHH22CCH3 ) 2 - -N ( CH2CH3 ) 2 TABLE 11 (Cont'd. ) — N—R 4 R 3 A> CH, / N * CH, TABLE 11 (Cont'd.) N— R 4 R3 A. N -CH 2 CH(CH3)2 o Example 17 The compounds of the present invention are effective HIV protease inhibitors. Utilizing an enzyme assay as described below, the compounds set forth in the examples herein disclosed inhibited the HIV enzyme. The preferred compounds of the present invention and their calculated IC50 (inhibiting concentration 50%, i.e., the concentration at which the inhibitor compound reduces enzyme activity by 50%) values are shown in Table 17. The enzyme method is described below. The substrate is 2-Ile-Nle-Phe (p-N02) -Gln-ArgNH2. The positive control is MVT-101 (Miller, M. et al, Science. 246. 1149 (1989)] The assay conditions are as follows: Assay buffer: 20 mM sodium phosphate, pH 6.4 20% glycerol 1 mM EDTA 1 mM DTT 0.1% CHAPS The above described substrate is dissolved in DMSO, then diluted 10 fold in assay buffer. Final substrate concentration in the assay is 80 μM. HIV protease is diluted in the assay buffer to a final enzyme concentration of 12.3 nanomolar, based on a molecular weight of 10,780. The final concentration of DMSO is 14% and the final concentration of glycerol is 18%. The test compound is dissolved in DMSO and diluted i n DMSO to lOx the teεt concentration; lOμl of the enzyme preparation iε added, the materials mixed and then the mixture is incubated at ambient temperature for 15 minutes. The enzyme reaction is initiated by the addition of 40μl of substrate. The increase in fluorescence is monitored at 4 time points (0, 8, 16 and 24 minutes) at ambient temperature. Each assay is carried out in duplicate wells. TABLE 12 Entry Compound IC50 Example 18 The effectiveness of the compounds can also be determined in a CEM cell assay. The HIV inhibition assay method of acutely infected cells is an automated tetrazolium based colorimetric assay essentially that reported by Pauwles et al, J. Virol. Methods. 20, 309-321 (1988) . Assays can be performed in 96-well tissue culture plates. CEM cells, a CD4+ cell line, were grown in RPMI -1640 medium (Gibco) supplemented with a 10% fetal calf serum and were then treated with polybrene (2μg/ml) . An 80 μl volume of medium containing 1 x 104 cells is diεpensed into each well of the tissue culture plate. To each well is added a lOOμl volume of test compound dissolved in tissue culture medium (or medium without test compound as a control) to achieve the desired final concentration and the cells are incubated at 37°C for 1 hour. A frozen culture of HIV-l is diluted in culture medium to a concentration of 5 x 10 4 TCID50 per ml (TCID50 = the dose of virus that infects 50% of cells in tissue culture) , and a 20μL volume of the virus sample (containing 1000 TCID50 of virus) is added to wells containing test compound and to wells containing only medium (infected control cells) . Several wells receive culture medium without virus (uninfected control cells) . Lilcewise, the intrinsic toxicity of the test compound is determined by adding medium without virus to several wells containing test compound. In summary, the tissue culture plates contain the following experiments: Virus Cells Drug 1 + 2. + 3. + + 4. + + In experiments 2 and 4 the final concentrations of test compounds are 1, 10, 100 and 500 μg/ml. Either azidothymidine (AZT) or dideoxyinosine (ddl) is included as a positive drug control. Test compounds are dissolved in DMSO and diluted into tissue culture medium so that the final DMSO concentration does not exceed 1.5% in any case. DMSO is added to all control wells at an appropriate concentration. Following the addition of virus, cells are incubated at 37°C in a humidified, 5% Cθ2 atmosphere for 7 days. Test compounds could be added on days 0, 2 and 5 if desired. On day 7, post-infection, the cells in each well are resuspended and a lOOμl sample of each cell εuεpension is removed for assay. A 20μL volume of a 5 mg/ml solution of 3- (4, 5-dimethylthiazol-2-yl) -2, 5- diphenyltetrazolium bromide (MTT) is added to each 100μL cell suspension, and the cells are incubated for 4 hours at 27°C in a 5% CO2 environment. During this incubation, MTT is metabolically reduced by living cells resulting in the production in the cell of a colored formazan product. To each sample is added lOOμl of 10% sodium dodecylsulfate in 0.01 N HCl to lyεe the cellf;, and εampleε are incubated overnight. The abεorbance at 590 nm is determined for each εample uεing a Molecular Devices microplate reader. Absorbance values for each set of wells is compared to asεeεs viral control infection, uninfected control cell response- as well as test compound by cytotoxicity and antiviral efficacy. The biological data of Table 13 was obtained for the compounds shown in Table IC. Table 13 Biological Data: Table IC Entry: IC50 or % inhibition EC50 TD50 A 29% @ 0.1 uM B 55% @ 10.0 uM C 59% @ 1.0 uM D 29% @ 0.1 uM E 70 nM 880 nM 7.5 uM F 22% @ 0.1 uM G 66 nM H 48% @ 10.0 uM I 1.7 uM J 2.69 uM K 60% @ 1.0 UM L 38% & 10.0 uM The compounds of the present invention are effective antiviral compounds and, in particular, are effective retroviral inhibitors as shown above. Thus, the subject compounds are effective HIV protease inhibitors. It is contemplated that the subject compounds will also inhibit other retroviruses such as other lentiviruses in particular other strains of HIV, e.g. HIV-2, human T-cell leukemia virus, respiratory syncitial virus, simia immunodeficiency virus, feline leukemia virus, feline immuno-deficiency virus, hepadnaviruε, cytomegaloviruε and picornaviruε. Thus, the subject compounds are effective in the treatment and/or proplylaxis of retroviral infections. Compounds of the present invention can posεess one or more aεymmetric carbon atoms and are thus capable of existing in the form of optical isomers as well as in the form of racemic or nonracemic mixtures thereof. The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, for example by formation of diastereoisomeric salts by treatment with an optically active acid or base. Examples of appropriate acids are tartaric, diacetyltartaric, dibenzoyltartaric, ditoluoyltartaric and camphorsulfonic acid and then separation of the mixture of diastereoisomers by cryεtallization followed by liberation of the optically active bases from these salts. A different process for separation of optical isomerε involveε the uεe of a chiral chromatography column optimally chosen to maximize the separation of the enantiomerε. Still another available method involveε syntheεis of covalent diasterpoisomeric molecules by reacting compounds of Formula 1 with an optically pure acid in an activated form or an optically pure isocyanate. The εynthesized diaεtereoiεomers can be separated by conventional means such as chromatography, distillation, crystallization or sublimation, and then hydrolyzed to deliver the enantiomerically pure compound. The optically active compoundε of Formula I can likewise be obtained by utilizing optically active starting materials. These isomers may be in the form of a free acid, a free base, an ester or a εalt. The compounds of the present invention can be used in the form of salts derived from inorganic or organic acids. These salts include but are not limited to the following: acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrat≤, camphorate, camphorsulfonate, digluconate, cyclopentanepropionate, dodecylsulfate, ethaneεulfonate, glucoheptanoate, glycerophosphate, hemiεuliate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxy-ethaneεulfonate, lactate, maleate, methanesulfonate, nicotinate, 2-naphthalenesulfonate, oxalate, palmoate, pectinate, perεulfate, 3-phenylpro- pionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, tosylate, meεylate and undecanoate. Also, the basic nitrogen-containing groupε can be quaternized with εuch agentε aε lower alkyl halideε, such as methyl, ethyl, propyl, and butyl chloride, bromides, and iodides; dialkyl sulfateε like dimethyl, d_ethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halideε like benzyl and phenethyl bromideε, and otherε. Water or oil-εoluble or dispersible products are thereby obtained. Examples of acids which may be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, sulphuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid and citric acid. Other examples include salts with alkali metals or alkaline earth metals, such as sodium, potassium, calcium or magnesium or with organic baseε. Total daily doεe adminiεtered to a noεt in εingle or divided doses may be in amounts, for example, from 0.001 to 50 mg/kg body weight daily and more usually 0.01 to 1 mg. Dosage unit compositions may contain such amounts of εubmultipleε thereof to make up the daily dose. The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of adminiεtration. The dosage regimen for treating a disease condition with the compounds and/or compositions of this invention is selected in accordance with a variety of factors, including the type, age, weight, sex, diet and medical condition of the patient, the εeverity of the diεeaεe, the route of adminiεtration, pharmacological considerations such as the activity, efficacy, pharmacokinetic and toxicology profiles of the particular compound employed, whether a drug delivery syεtem iε utilized and whether the compound is administered as part of a drug combination. Thuε, the dosage regimen actually employed may vary widely and therefore may deviate from the preferred dosage regimen set forth above. The compoundε of the preεent invention may be administered orally, parenterally, by inhalation spray, rectally, or topically in doεage unit formulations containing conventional nontoxic pharmaceutically acceptable carriers, adjuvants, and vehicles as desired. Topical administration may also involve the use of transdermal administration such as transdermal patches or iontophoreεiε devices. The term parenteral as used herein includes εubcutaneouε injectionε, intravenous, intramuscular, intrasternal injection, or infuεion techniqueε. Injectable preparationε, for example, sterile injectable aqueous or oleaginous suεpenεions may be formulated according to the known art using suitable dispersing or wetting agents and suεpending agentε. The sterile injectable preparation may also be a sterile injectable εolution or εuεpension in a nontoxic parenterally acceptable diluent or solvent, for example, as a solution in 1, 3-butanediol . Among the acceptable vehicles and solventε that may be employed are water, Ringer' ε solution, and isotonic sodium chloride εolution. In addition, εterilε, fixed oilε are conventionally employed as a solvent or suεpending medium. For this purpose any bland fixed oil may be employed including εynthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. Suppositories for rectal administration of the drug can be prepared by mixing the drug with a suitable nonirritating excipient such as cocoa butter and polyethylene glycols which are solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum and releaεe the drug. Solid dosage forms for oral administration may include capsules, tablets, pills, powders, and granuleε. In such solid dosage forms, the active compound may be admixed with at leaεt one inert diluent such as sucroεe lactose or starch. Such dosage forms may also comprise, as in normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate. In the caεe of capεules, tablets, and pills, the dosage forms may also comprise buffering agents. Tablets and pills can additionally be preparsd with enteric coatings. Liquid dosage forms for oral administration may include pharmaceutically acceptable emulsionε, εolutionε, εuεpensions, syrupε, and elixirε containing inert diluents commonly uεed in the art, εuch aε water. Such compoεitions may also comprise adjuvants, such as wetting agentε, emulεifying and suεpending agentε, and εweetening, flavoring, and perfuming agentε. While the compounds of the invention can be adminiεtered as the sole active pharmaceutical agent, they can alεo be uεed in combination with one or more immunomodulatorε, antiviral agents or other antiinfective agentε. For example, the compoundε of the invention can be adminiεtered in combination with AZT, DDI, DDC or with glucoεidaεe inhibitors, εuch aε N-butyl-1-deoxynojirimycin or prodrugε thereof, for the prophylaxis and/or treatment of AIDS. When adminiεtered as a combination, the therapeutic agents can be formulated as separate compositionε which are given at the same time or different times, or the therapeutic agentε can be given as a single composition. The foregoing is merely illustrative of the invention and is not intended to limit the invention to the disclosed compounds. Variationε and changeε which are obviouε to one εkilled in the art are intended to be within the scope and nature of the invention which are defined in the appended claims. From the foregoing description, one skilled in the art can eaεily aεcertain the eεεential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to variouε uεageε and conditionε.

Claims: WHAT IS CLAIMED IS: 1. A compound repreεented by the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof wherein: Rl representε hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3 )2 (SCH3) , -C(CH3)2 (S[0]CH3) , -C(CH3)2 (Ξ[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicalε, and amino acid side chains selected from asparagine, S-methyl cysteine methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, isoleucine, allo-iεoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, hiεtidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-alkyl serine, aspartic acid, beta-cyano alanine and valine side chains; R-2 represents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally subεtituted with a group εelected from alkyl and halogen radicalε, -NO2, -C≡N, CF 3 , -OR9< -SR9, wherein R9 represents hydrogen and alkyl radicals; R3 repreεentε alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and diεubεtituted aminoalkyl radicalε, wherein εaid substituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubεtituted aminoalkyl radical, εaid substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone and sulfoxide derivativeε thereof; R and R 5 independently repreεent hydrogen and radicals as defined by R3 or together with a nitrogen atom to which they are bonded form a heterocycloalkyl or a heteroaryl radical; R6 represents hydrogen and alkyl radicals; R30, R 3i an R 32 independently represent hydrogen and alkyl, alkenyl and alkynyl radicals, or one of R--- and R-30 together with one of R-3***- and R^ 2 and the carbon atomε to which they are attached form a cycloalkyl radical; F.33 and F.3 independently represent hydrogen and radicals as defined for R3 , or R-33 and R34 together with X' represent cycloalkyl, aryl, heterocyclyl and heteroaryl radicalε, provided that when X' is 0, R3 j. s absent. X' represents N, O and C(R-^-^) wherein R^ 7 represents hydrogen and alkyl radicals; x represents 1, or 2; t representε either 0, 1 or 2; and Y and Y' independently represent O, S and NR15 wherein F.---- represents hydrogen and radicals as defined for R3. 2. Compound represented by the formula: wherein: Rl represents hydrogen, -CH2SO2NH2, -CH2CO2CH3 , -CO2CH3, -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3)2 (SCH3) , -C(CH3)2(S[0]CH3) , -C (CH3 ) 2 (S [0]2CH3 ) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chainε εelected from asparagine, S-meπhyl cysteine methionine and the sulfoxide (SO) and sulfone (SO2) derivativeε thereof, iεoleucine, allo-iεoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonine, glycine, allo-threonine, serine, O-methyl serine, aspartic acid, beta-cyanoalanine and valine εide chains; R-2 repreεentε alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicalε are optionally substituted with a group selected from alkyl and halogen radicals, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R9 represents hydrogen and alkyl radicals; R represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicals, wherein said εubεtituentε are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicals, or in the case of a disubstituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone and sulfoxide derivatives thereof; R4 and R 5 independently represent hydrogen and radicals as defined by R , or together with the nitrogen atom to which they are bonded repreεent heterocycloalkyl and heteroaryl radicals; R 0, R 3i an( j R 32 independently represent radicals as defined for R1, or one of RI and R 0 together with one of R 1 and R32 a nd the carbon atoms to which they are attached form a cycloalkyl radical; R33 and R34 independently represent hydrogen and radicals as defined for R3 , or R33 and R34 together with the nitrogen atom to which they are attached represent heterocycloalkyl and heteroaryl radicals. 3. Compound of Claim 2 wherein Rl represents hydrogen and CH 2 C (0)NHCH 3 , C (CH 3 ) 2 (SCH 3 ) , C(CH 3 ) 2 (Ξ[0]CH 3 ) , C(CH 3 ) 2 (S[0] 2 CH 3 ) , alkyl, alkenyl and alkynyl radicals, and amino acid side chains selected from the group consiεting of asparagine, valine, threonine, allo-threonine, isoleucine, terτ.-leucine, S-methyl cysteine and the sulfone and sulfoxide derivativeε thereof, methionine and the εulfone and εulfoxide derivativeε thereof, alanine, and allo- iεoleucine. 4. Compound of Claim 2 wherein Rl representε hydrogen and CH 2 C (0)NHCH 3 , C (CH 3 ) (SCH 3 ) , C(CH 3 ) 2 (S[0]CH 3 ) , C(CH 3 ) 2 (S[0] 2 CH 3 ) , methyl, propargyl, t-butyl and εec-butyl radicalε, and amino acid side chains selected from the group consisting of asparagine, valine, S-methyl cysteine, allo-iso-leucine, iso-leucine, and beta-cyano alanine εide chains. 5. Compound of Claim 2 wherein R 1 , R 30 , R31 and R 2 independently represent an alkyl radical having from one to four carbon atoms. 6. Compound of Claim 2 wherein R U i s hydrogen and R1, R 1 and R3 are independently hydrog?r, methyl and ethyl radicalε. 7. Compound of Claim 2 wherein R30 is hydrogen and R1, R31 and R 2 a ll methyl represent a methyl radical. 8. Compound of Claim 2 wherein R30 i s hydrogen and R1 together with one of F.3-**- and R32 a nd the carbon atoms to which they are attached form a cycloalkyl radical having from 3 to 8 carbon atomε. 9. Compound of Claim 2 wherein R represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally εubεtituted with halogen radicals and radicals represented by the formula -OR- Q and -SR9 wherein F.9 representε hydrogen and alkyl radicalε. 10. Compound of Claim 2 wherein R2 representε alkyl, cycloalkylalkyl and aralkyl radicals. 11. Compound of Claim 2 wherein R repreεentε CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4- fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals. 12. Compound of Claim 2 wherein R independently represents alkyl, haloalkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl. aralkyl and heteroaralkyl radicals. 13. Compound of Claim 2 wherein 3 represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, heterocycloalkyl, heterocycloalkylalkyl radicals. 14. Compound of Claim 2 wherein R repreεents alkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 15. Compound of Claim 2 wherein R3 represents isobutyl, n-propyl, isopropyl, n-butyl, isoamyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals. 16. Compound of Claim 2 wherein R 4 and R 5 independently repreεent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 17. Compound of Claim 2 wherein R 4 and R^ independently represent hydrogen, alkyl and aryl radicals. 18. Compound of Claim 2 wherein R 4 and R 5 independently represent hydrogen, methyl, ethyl, propyl, isopropyl, n-butyl, t-butyl, 1, 1-dimethylpropyl, cyclohexyl and phenyl radicals. 19. Compound of Claim 2 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a heterocyloalkyl or heteroaryl radical. 20. Compound of Claim 2 wherein R 4 and R5 together with the nitrogen atom to which they are bonded form a heterocycloalkyl or heteroaryl radical having from 4 to 8 ring members. 21. Compound of Claim 2 wherein R 4 and R5 together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl piperazinyl or N' -alkylpiperazinyl radical. 22. Compound of Claim 2 wherein R3 an d R3 4 are independently selected from hydrogen, alkyl and aralkyl radicals. 23. Compound of Claim 2 wherein R3 and R34 independently represent methyl, ethyl, propyl, butyl, pentyl and hexyl radicals, cyclohexylmethyl, cyclohexyl, benzyl and naphthylmethyl radicals. 24. A pharmaceutical composition comprising a compound of Claim 1 and a pharmaceutically acceptable carrier. 25. A pharmaceutical compoεition comprising a compound of Claim 2 and a pharmaceutically acceptable carrier. 26. Method of inhibiting a retroviral protease comprising administering a proteaεe inhibiting amount of a compoεition of Claim 24. 27. Method of Claim 26 wherein the retroviral proteaεe iε HIV proteaεe. 28. Method of treating a retroviral infection compriεing adminiεtering an effective amount of a composition of Claim 24. 29. Method of Claim 28 wherein the retroviral infection iε an HIV infection. 30. Method for treating AIDS compriεing adminiεtering an effective amount of a compoεition of Claim 24. 31. Method of inhibiting a retroviral proteaεe comprising administering a proteaεe inhibiting amount of a compoεition of Claim 25. 32. Method of Claim 31 wherein the retroviral proteaεe is HIV protease. 33. Method of treating a retroviral infection compriεing administering an effective amount of a composition of Claim 25. 34. Method of Claim 31 wherein the retroviral infection is an HIV infection. 35. Method for treating AIDS comprising administering an effective amount of a composition of Claim 25. 36. Compound represented by the formula: wherein: Rl represents hydrogen, -CH2S02NH2 -CH2CO2CH3 , -CO2CH3 , -CONH2, -CH 2 C(0)NHCH3, -C (CH 3 ) 2 (SH) , -C (CH3) 2 (SCH3) , -C(CH3)2 (S[0]CH3) , -C (CH3) 2 (S[0]2CH3) , alkyl, haloalkyl, alkenyl, alkynyl and cycloalkyl radicals, and amino acid side chainε selected from asparagine, S-methyl cysteine methionine and the sulfoxide (SO) and sulfone (SO2) derivatives thereof, iεoleucine, allo-isoleucine, alanine, leucine, tert-leucine, phenylalanine, ornithine, histidine, norleucine, glutamine, threonin---, glycine, allo-threonine, serine, aspartic acid, beta-cyanoalanine and valine side chains; R2 repreεents alkyl, aryl, cycloalkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with a group selected from alkyl and halogen radicals, -NO2, -C≡N, CF 3 , -OR9, -SR9, wherein R9 representε hydrogen and alkyl radicals; R3 represents alkyl, haloalkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylalkyl, aryl, aralkyl, heteroaralkyl, aminoalkyl and mono- and disubstituted aminoalkyl radicalε, wherein εaid εubstituents are selected from alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl, and heterocycloalkylalkyl radicalε, or in the case of a diεubεtituted aminoalkyl radical, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical, and thioalkyl, alkylthioalkyl and arylthioalkyl radicals and the sulfone and sulfoxide derivative thereof; R 4 and R 5 independently represent hydrogen and radicals as defined by R3 , or together with the nitrogen atom to which they are bonded represent heterocycloalkyl and heteroaryl radicals; R30, R 31 anc * } R 32 independently represent radicals as defined for R1, or one of R1 and R 0 together with one of R31 and R32 and the carbon atoms to which they are attached form a cycloalkyl radical; and R representε hydrogen and radicals aε defined for R 3 . 37. Compound of Claim 3 wherein Rl represents hydrogen and CH 2 C (0)NHCH 3 , C (CH 3 ) 2 (SCH 3 ) , C(CH 3 ) (S[0]CH 3 ) , C(CH 3 ) 2 (S[0] 2 CH 3 ) , alkyl, alkenyl and alkynyl radicals, and amino acid side chainε εelected from the group conεiεting of aεparagine, valine, threonine, allo-threonine, isoleucine, terc-leucine, S-methyl cysteine and the sulfone and sulfoxide derivativeε thereof, methionine and the εulfone and εulfoxide derivatives thereof, alanine, and allo- isoleucine. 38. Compound of Claim 4 wherein Rl represents hydrogen and CH 2 C (0)NHCH 3 , C (CH 3 ) 2 (SCH 3 ) , C(CH 3 ) 2 (S[0]CH 3 ) , C(CH 3 ) 2 (S[0] 2 CH 3 ) , methyl, propargyl, t-butyl and sec-butyl radicalε, and amino acid εide chainε εelected from the group consisting of asparagine, valine, S-methyl cysteine, allo-iso-leucine, iso-leucine, and beta-cyano alanine side chains. 39. Compound of Claim 5 wherein R 1 , R30, R31 and R32 independently represent an alkyl radical having from one to four carbon atoms. 40. Compound of Claim 6 wherein R30 i s hydrogen and Rl, R31 and R32 a re independently hydrogen, methyl and ethyl radicals. 41. Compound of Claim 7 wherein R U is hydrogen and R-^*, R 1 and R32 a ll methyl represent a methyl radical. 42. Compound of Claim 8 wherein R 0 is hydrogen and R 1 together with one of R 1 and R3 and the carbon atoms to which they are attached form a cycloalkyl radical having from 3 to 8 carbon atoms. 43. Compound of Claim 36 wherein R2 represents alkyl, cycloalkylalkyl and aralkyl radicals, which radicals are optionally substituted with halogen radicalε and radicalε represented by the formula -OR9 and -SR9 wherein R9 represents hydrogen and alkyl radicals. 44. Compound of Claim 36 wherein P. represents alkyl, cycloalkylalkyl and aralkyl radicals. 45. Compound of Claim 36 wherein R2 represents CH3SCH2CH2-, iso-butyl, n-butyl, benzyl, 4-fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicals. 46. Compound of Claim 36 wherein R2 represents benzyl, 4-fluorobenzyl, and 2-naphthylmethyl radicals. 47. Compound of Claim 36 wherein R3 independently represents alkyl, haloalkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl and heteroaralkyl radicals. 48. Compound of Claim 36 wherein R3 represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, heterocycloalkyl, heterocycloalkylalkyl radicals. 49. Compound of Claim 36 wherein R3 and R 4 independently represent alkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 50. Compound of Claim 36 wherein R representε iεobutyl, n-propyl, isopropyl, n-butyl, isoamyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals. 51. Compound of Claim 36 wherein R representε CH3SCH2CH2-, iεo-butyl, n-butyl, benzyl, 4- fluorobenzyl, 2-naphthylmethyl and cyclohexylmethyl radicalε. 52. Compound of Claim 36 wherein R3 independently represents alkyl, haloalkyl, alkenyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, aralkyl and heteroaralkyl radicalε. 53. Compound of Claim 36 wherein 3 repreεentε alkyl, cycloalkyl, cycloalkylalkyl, aralkyl. heteroaralkyl, heterocycloalkyl, heterocycloalkylalkyl radicals. 54. Compound of Claim 36 wherein R3 represents alkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 55. Compound of Claim 36 wherein R representε iεobutyl, n-propyl, iεopropyl, n-butyl, isoamyl, cyclohexyl, cyclohexylmethyl, benzyl and pyridylmethyl radicals. 56. Compound of Claim 36 wherein R represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, heteroaralkyl, heterocycloalkyl, heterocycloalkylalkyl radicals. 57. Compound of Claim 36 wherein R 4 and R^ independently represent hydrogen, alkyl and aryl radicals. 58. Compound of Claim 36 wherein R 4 and R^ independently represent hydrogen, methyl, ethyl, propyl, isopropyl, n-butyl, t-butyl, 1, 1-dimethyIpropyl, cyclohexyl and phenyl radicals. 59. Compound of Claim 36 wherein R 4 anc j R 5 together with the nitrogen atom to which th*=y are bonded form a heterocyloalkyl or heteroaryl radical. 60. Compound of Claim 36 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a heterocycloalkyl or heteroaryl radical having from 4 to 8 ring members. 61. Compound of Claim 36 wherein R 4 and R 5 independently represent hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals. 62. Compound of Claim 36 wherein R 4 and R5 independently represent hydrogen, alkyl an., aryl radicals . 63. Compound of Claim 36 wherein R 4 and R^ independently represent hydrogen, methyl, ethyl, propyl, isopropyl, n-butyl, t-butyl, 1, 1-dimethyIpropyl, cyclohexyl and phenyl radicals. 64. Compound of Claim 36 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a heterocyloalkyl or heteroaryl radical. 65. Compound of Claim 36 wherein P 4 and R^ together with the nitrogen atom to which they are bonded form a heterocycloalkyl or heteroaryl radical naving from 4 to 8 ring members. 66. Compound of Claim 36 wherein R 4 and R^ together with the nitrogen atom to which they are bonded form a pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or N' -alkylpiperazinyl radical. 67. Compound of Claim 36 wherein R 3 i s a branched or unbranched alkyl radical of from one to six carbon atoms or a benzyl radical. 68. Compound of Claim 36 wherein R33 i s hydrogen. 69. A pharmaceutical composition comprising a compound of Claim 36 and a pharmaceutically acceptable carrier. 70. Method of inhibiting a retroviral protease compriεing adminiεtering a protease inhibiting amount of a composition of Claim 69. 71. Method of Claim 70 wherein the retroviral protease is HIV protease. 72. Method of treating a retroviral infection comprising administering an effective amount of a composition of Claim 69. 73. Method of Claim 72 wherein the retroviral infection is an HIV infection. 74. Method for treating AIDS comprising administering an effective amount of a composition of Claim 69.

Inventors: DE CRESCENZO GARY A, GETMAN DANIEL P, MUELLER RICHARD A, SUN ERIC T, TALLEY JOHN J, VAZQUEZ MICHAEL L, DE CRESCENZO, GARY, A., GETMAN, DANIEL, P., MUELLER, RICHARD, A., SUN, ERIC, T., TALLEY, JOHN, J., VAZQUEZ, MICHAEL, L.
Applicants: CRESCENZO GARY A DE, GETMAN DANIEL P, MONSANTO CO, MUELLER RICHARD A, SEARLE & CO, SUN ERIC T, TALLEY JOHN J, VAZQUEZ MICHAEL L, DE CRESCENZO, GARY, A., G.D. SEARLE & CO., GETMAN, DANIEL, P., MUELLER, RICHARD, A., SUN, ERIC, T., TALLEY, JOHN, J., THE MONSATO COMPANY, VAZQUEZ, MICHAEL, L.
Application year: 1993
Main classification: C07C307
IPC codes: C07C307, C07D295