SKIN REGENERATING COSMETIC COMPOSITION

Abstract: The invention relates to skin regenerating cosmetic compositions comprising as active ingredient the extract of the drug of chickweed (Stellaria media) and pansy (Viola tricolor) in a quantity of 3-60% by weight together with one or more cosmetically acceptable vehicle and/or excipient and/or supplementary material in a quantity of 97-40% by weight.

Description: SKIN REGENERATING COSMETIC COMPOSITION The invention relates to skin regenerating cosmetic compositions comprising as active ingredient 3-60% by weight of extracts of Stellaria media and Viola tricolor. The increasing number of environmental injuries, the polluted air, numerous flats not providing suitable micro¬ climate are causing various skin complaints in many people. In mild cases these appear in form of pathologically dry, inflammable, scurfy, itching skin deformations. When the skin problems are more serious dermatologists suggest the use of pharmaceutical compositions generally containing synthetic active ingredients. In case of relatively mild deformations in the litera¬ ture various paramedicinal or cosmetic composition are re¬ commended to cease the symptoms. Such a composition is described for example in the HU¬ PS 195.420 which contains extracts of St. John,s wort and marigold, tocopherol, collagen, allantoin, panthenol, jojoba oil, chamomile oil and chamomile extract. According to HU-PS-195.915 the extract of different parts of the maize plant prepared with water or with water miscible pharmaceutically acceptable organic solvents is formulated together with the usual excipients, diluents or vehicles to skin regenerating and hydrating cosmetic compo¬ sition. A topical composition of similar effect is described in HU-PS 184.410, wich contains as active ingredient the aqueous or ethanolic extracts of drugs of species belonging to the Fagaceae and/or Chenopodicae and/or Rosaceae fami¬ lies. With regard to the great variety of symptoms, the different sensitivity of the individuals, the potential allergic skin reactions, no composition is known which could be generally applied for the above group of symptoms. The aim of our work was to prepare a new cosmetic composition which would enrich the choice of available compositions. Our further aim was to create a synergetic composition free of harmful side effects, comprising essen- tially natural active ingredients, suitable for the treat¬ ment of pathologically dry, inflammable, scurfy, itching skin deformations, eczemas and acnes in milder cases which do not require medical intervention. We have surprisingly found that the above aims can be reached with a composition comprising as active ingredient extracts of chickweed (Stellaria media) and pansy (Viola tricolor) . The chickweed belongs to the family of Caryophyllaceae, its drug is the overground part of the plant collected in time of flowering. The main active ingredients of the drug are volatile oils, organic and inorganic salts, saponines. In case of internal use its antiphlogistic, blood-clearing, antipyretic, expectorating and antitussive effects are known. Externally its oily extract is suitable for the treatment of eruptions and certain types of psoriasis. The pansy belongs to the family of Violaceae, its drug is he overground part of the plant, collected in time of flowering. The main active ingredients of the drug are violaquercetin, flavone glycoside, quercetin glycone, violanin anthocyan glycoside, sugars, organic acids, methyl ester of salicylic acid, volatile oils. The tea made from the drug has expectorating, blood- clearing, hypotensive effects. The skin regenerating cosmetic compositions according to the invention contain the oily or aquaeous and/or cosme¬ tically acceptable organic solvent extracts of the drog of chickweed and pansy in a quantity of 3-60% by weight calcu¬ lated for the total amount of the composition together with one or more cosmetically suitable vehicle aήd/or excipient and/or supplementary material in a quantity of 97-40% by weight. The compositions contain the extracts of the chickweed and pansy in a weight ratio from 7:1 to 1:7. For preparing the compositions aqueous, aqueous ethanolic, aqueous propylene glycolic, cosmetic vaseline oily plant extracts can equally be used. As vehicle the composition can contain artificial or natural fats, oils, fatty alcohols, esters of fatty acids and/or the derivatives thereof. Suitable excipients are the thickening, epithelium regenerating, skin soothing, skin nurishing, tonic, anti¬ septic, moisturizing, solubilizing materials, stabilisers, preservatives, emulgeators, fillers, vitamins and fragrance. The composition may contain supplementary components, such as light protecting materials, for example octyl- methoxy-cinnamate. The plant extracts can be prepared in the usual way, among others by a process based on diffusion extraction (steeping, circulation extraction or counter-current extrac¬ tion) . In these cases the parts of the plants are optionally dried, then crushed and extracted with 2-30 times the weight of extractive agent based on the amount of dried plants. The extraction is carried out preferably at a tempera¬ ture between 15°C and the boiling point of the extractive agent, by steeping the plant for 2-3 days or by counter- current extraction for 1 hour. In case of large scale embodiment it is advantageous to extract the plant at a higher temperature and for a shorter time, and if appropriate, combine the extraction with solvent recovery. The plants can be extracted separately, and the ext¬ racts can be mixed when the composition is made, or the drugs can be blended in a determined ratio before the ext¬ raction. The synergetic effect of the composition according to the invention was also examined. The details are described in the Comparative examples, and the results are summarized in the subsequent Table. The solution according to our invention is illustrated by the following examples without limiting the scope of the invention. Example 1 1 kg of dried, crushed drug of pansy was washed with water, then soaked in 2 kg of deionized water at room tempe- rature for 2 days, with occasional stirring. After that the mixture was filtered. Example 2 1 kg of dried, crushed drug of pansy was washed with water, then extracted with 30 kg of water at 90"C for 30 minutes in an extractor. After cooling the extract was filtered. The solution obtained was tyndalled by heating it once a day to 80°C for 1 hour through 3 days. Example 3 The process described in Example 1 was followed, but for soaking water containing 30% by volume of propylene glycol was used. Example 4 1 kg of dried, crushed, washed drug of pansy was ext¬ racted with 10 kg of 70% by volume aqueous ethanol for 10 hours at 40 °C, under stirring. The extract obtained was filtered. Example 5 1 kg of dried, crushed, washed drug of pansy was ext¬ racted with 15 kg of cosmetic vaseline oil at 20°C for 2 days, stirring the mixture several times. The plant pieces were removed by centrifuging, then the oily part was filtered. Example 6 The process described in Example 1 was followed, but instead of the drug of pansy the drug of chickweed was extracted. Example 7 The process described in Example 2 was followed, but instead of the drug of pansy the drug of chickweed was ext¬ racted. Example 8 The process described in Example 1 was followed, but instead of the drug of pansy the drug of chickweed was extracted with 2 kg of water containing 10% by volume propylene glycol. Example 9 The process described in Example 4 was followed, but instead of the drug of pansy the drug of chickweed was ext- racted with 50% by volume aqueous ethanol. Example 10 The process described in Example 5 was followed, but instead of the drug of pansy the drug of chickweed was ext- racted. Example 11 0,5 kg drug of pansy and 0,5 kg drug of chickweed was mixed, then thoroughly washed with water and extracted with 8 kg of water at 90°C for 50 minutes in a counter-current extractor. The solid part and liquid phase were separated by filtration. Example 12 Emulsion composition: Aqueous pansy extract obtained in Example 1 2.62 g Aqueous chickweed extract obtained in Example 6 0.38 g Hydrogenated castor oil 6.00 g Avocado oil 4.00 g Maizen germ oil 3.00 g Vaseline oil 14.00 g Cetyl alcohol 1.00 g Propylene glycol 4.00 g Vitamin A 0.05 g Vitamin E 0.07 g Preservative 0.10 g Fragrance 0.10 g Deionized water ad 100.00 g Example 13 Nurishing night cream composition: Aqueous pansy extract obtained in Example 2 7.50 g Aqueous chickweed extract obtained in Example 7 52.50 g Hydrogenated castor oil 10.00 g White vaseline 5.00 g Lanette N (a mixture of sodium cetyl-stearyl sulfate and cetyl-stearyl alcohol, sold, HENKEL, DE) 2.00 g Avocado oil 10.00 g Vaseline oil 4.00 g Wheat germ oil 5.00 g Cholesterol 2.60 g Glycerol 0.50 g Vitamin A 0.05 g Vitamin E 0.05 g Preservative 0.10 g Fragrance 0.10 g Deionized water ad 100.00 g Example 14 Night face cream composition: Oily pansy extract obtained in Example 5 10.00 g Oily chickweed extract obtained in Example 10 10.00 g Cutina MD (a mixture of mono- and diglycerides of palmitic and stearic acids, HENKEL, DE) 4.00 g Stearol 8.00 g Emulgin Bl (cetyl-stearyl-alcohol, HENKEL, DE) 1.50 g Emulgin B2 (cetyl-stearyl-alcohol, HENKEL, DE) 1.50 g Eutanol G (2-octyl-dodecanol, HENKEL, DE) 15.00 g Cutina BW (partial glyceride and ester of long chain fatty acids, HENKEL, DE) 2.00 g Trietanolamine 0.20 g Deionized water 47.80 g Example 15 Face tonic composition: Ethanolic pansy extract obtained in Example 4 25.00 g Ethanolic chickweed extract obtained in Example 9 15.00 g Glycerol 2.00 g Allantoin 0.20 g Cetiol HE (polyetylene glycol-7-glyceryl- cocate, HENKEL, DE) 2.00 g Ethanol, 96% by volume 5.20 g Deionized water ad 100.00 g Example 16 Liquid cleansing emulsion composition: Propylene glycolic pansy extract obtained in Example 3 9.00 g Propylene glycolic chickweed extract obtained in Example 8 11.00 g Texapon EVR (sodium lauryl-ether sulfate with special ingredients, HENKEL, DE) 40.00 g Texapon N 40 (sodium lauryl-ether sulfate, HENKEL, DE) 40.00 g Example 17 Light protecting emulsion Aque o us extract obtained in Example 11 30.00 g Glyc rol-sorbitan-hydroxy-isostearate 5.00 g Isopropyl myristate 5.00 g Cyclic dimethyl-polysiloxane 3.00 g Polyoxyethylene stearyl-stearate 4.00 g Propylene glycol 2.00 g Etoxylated, hydrogenated castor oil 0,50 g Hydrogenated castor oil 0.70 g Fragrance 0.10 g Olive oil 10.00 g Octyl-methoxy-cinnanate 0.20 g Deionized water ad 100.00 g Example 18 Body lotion Extract obtained in Example 3 2.00 g Extract obtained in Example 8 2.00 g Polyglyceryl-3-dioleate 4.00 g White vaseline 10.00 g White wax 2.00 g Paraffine, microcrystalline 2.00 g Alfa-bisabolol 0.20 g Dichloro-benzyl alcohol 0.10 g Cetearyl octanoate 8.00 g Magnesium sulfate heptahydrate 0.70 g Allantoin 0.40 g Imidazolidinyl urea 0.30 g Deionized water ad 100.00 g Example 19 Face peeling masc composition: Aqueous extract obtained in Example 11 25.00 g Cetyl-stearyl alcohol 10.00 g Paraffin oil 10.00 g Almond oil 3.00 g Myristyl-ethoxy-myristate 2.00 g Apricot kernel powder 2.00 g Allantoin 0.20 g Sepicide HB (paraben and phenoxy-ethanol, SEPPIC, FR) 0.30 g Fragrance 0.20 g Deionized water ad 100.00 g Comparative example 1 The composition of Example 18 was prepared, but instead of pansy extract the same quantity of deionized water was used. The composition was examined on 25 women and 5 men aged from 30 to 55 years. The face skin of the treated persons were dry, slightly inflamed, scurfy and in some cases itching. The composition was applied twice a day for two weeks. After this period the effect was evaluated and the following results were obtained: - in 13 cases no change was observed, - in 7 cases the desquamation and itching was lessening, - in 6 cases the desquamation, itching and inflammation was lessening, but the skin was dry, - in 4 cases the complaints were ceased. Comparative example 2 The composition of Example 18 was prepared, but instead of chickweed extract the same quantity of deinoized water was used. The composition was examined on 24 women and 6 men aged from 32 to 58 years. The symptoms, the treatment and the way of evaluation was the same as described in Compara¬ tive example 1. Results: - in 14 cases no change was observed, - in 5 cases the inflammation and itching were lessening. but the skin was dry and scurfy, - in 8 cases the inflammation and desquamation was significantly lessening, but the skin was still itching and dry, - in 3 cases there were no complaints. Comparative example 3 The composition of Example 18 was prepared, but instead of the two plant extracts deionized water was used. The composition was examined on 27 women and 3 men aged from 33 to 57 years. The symptoms, the treatment and the way of eva¬ luation was the same as described in Comparative example 1. Results: - in 25 case the symptoms were not lessening, - in 4 cases inflammation was hardly observable, dry ness and desqumation were slightly lessening, - in 1 case all the symptoms were lessening in a medium degree. Comparative example 4 The composition of Example 18 was examined on 26 women and 4 men aged from 31 to 60 years. The symptoms, the treatment and the way of evaluation was the same as descri¬ bed in Comparative example 1. Results: - in 1 case the symptoms were not lessening, - in 2 cases inflammation, dryness, desquamation in a small degree could be well observed, - in 4 cases the inflammation and itching in a small deg ree, the dryness and desquamation to a high extent were lessening, - in 23 cases the treated persons became symptom-free. Table Summary of the results obtained in Comparative examples 1-4 (%, based on the sample of 30 persons) Example No effect Effect of the composition number was observed weak medium good 1 ' 43 23 20 14 2 46 17 27 10 3 83 14 3 - 4 3 7 13 77

Claims: We claim : 1. Skin regenerating cosmetic compositions comprising oily or aqueous and/or cosmetically acceptable organic solvent extracts of chickweed (Stellaria media) and pansy (Viola tricolor) drugs in a quantity of 3-60 % by weight together with one or more cosmetically acceptable carrier and/or excipient and/or supplementary material in a quantity of 97-40% by weight. 2. The composition of claim 1 comprising the extracts of chickweed and pansy in a ratio 7:1 - 1:7. 3. The composition of claim 1 or claim 2 comprising the aqueous extracts of the plants. 4. The composition of claim 1 or claim 2 comprising the aqueous ethanolic extracts of the plants. 5. The composition of claim 1 or claim 2 comprising the aqueous propylene glycolic extracts of the plants. 6. The composition of claim 1 or claim 2 comprising the cosmetic vaseline oily extracts of the plants. 7. The composition of claim 1 or claim 2 comprising artifi¬ cial or natural fats, oils, fatty alcohols, fatty acid esters and/or derivatives thereof as vehicle. 8. The composition of claim 1 or claim 2 comprising one or more thickening material, epithelium regenerating, skin nurishing, antiseptic, tonic material, stabilizer, preser¬ vative, e ulsifier, filler, vitamin, fragrance as excipient. 9. The composition of claim 1 or 2 comprising light protec¬ ting material as supplementary material. 10. The composition of claim 9 comprising octyl methoxy- innanate as light protecting material.

Inventors: AGNI ZSOLT, APAGYI ERIKA, BERECZKI ERZSEBET, DEMKO GABRIELLA, FABIAN AGNES, HANGACSI IREN, HEGEDUES EVA, JACSO ERIKA, JAKAB TUENDE, KARANCSI ERIKA, KEREK KALMAN, KOVACS ANIKO, NAGY ILONA, PAPP GABRIELLA, SAS ERZSEBET, SZABO EVA, SZABO TUENDE, SZALOKI ERZSEBET, AGNI, ZSOLT, APAGYI, ERIKA, BERECZKI, ERZSEBET, DEMKO, GABRIELLA, FABIAN, AGNES, HANGACSI, IREN, HEGEDUES, EVA, JACSO, ERIKA, JAKAB, TUENDE, KARANCSI, ERIKA, KEREK, KALMAN, KOVACS, ANIKO, NAGY, ILONA, PAPP, GABRIELLA, SAS, ERZSEBET, SZABO, EVA, SZABO, TUENDE, SZALOKI, ERZSEBET
Applicants: AGNI ZSOLT, APAGYI ERIKA, BERECZKI ERZSEBET, BIOGAL GYOGYSZERGYAR, DEMKO GABRIELLA, FABIAN AGNES, HANGACSI IREN, HEGEDUES EVA, JACSO ERIKA, JAKAB TUENDE, KARANCSI ERIKA, KEREK KALMAN, KOVACS ANIKO, NAGY ILONA, PAPP GABRIELLA, SAS ERZSEBET, SZABO EVA, SZABO TUENDE, SZALOKI ERZSEBET, BIOGAL GYOGYSZERGYAR RT
Application year: 1993
Main classification: A61K7
IPC codes: A61K8, A61Q17, A61Q19