SUBSTITUTED 6-AZAANDROSTENONES

Abstract: The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R<1> and R<2> i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R<1> and R<2> is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R<1> and R<2> is a single bond; R<3> is preferably hydrogen, halogen or lower alkyl, R<4> is preferably hydrogen or lower alkyl, X is preferably CH2, Y is preferably hydrogen and Z is preferably CONR<14>R<15> and R<14> and R<15> are a variety of organic groups, and pharmaceutically acceptable salts thereof, preparation, medical use and pharmaceutical formulations.

Description: SUBSTITUTED 6-AZAANDROSTENONES The present invention relates to certain substituted 17β-substituted -6- azaandrost-4-en-3-ones and their use as 5α-testosterone reductase inhibitors. BACKGROUND OF THE INVENTION Androgens are responsible for many physiological functions in both males and females. Androgen action is mediated by specific intracellular hormone receptors expressed in androgen responsive cells. Testosterone, the major circulating androgen, is secreted by Leydig cells of the testes under the stimulation of pituitary-derived luteinizing hormone (LH). However, reduction of the 4,5 double bond of testosterone to dihydrotestosterone (DHT) is required in some target tissues, such as prostate and skin, for androgen action. Steroid 5α-reductases in target tissues catalyze conversion of testosterone to DHT in an NADPH dependent fashion as shown in Scheme A. 5o--reductases NADPH NADP + Dihydrotestosterone SCHEME A The requirement for DHT to act as an agonist in these target tissues has been highlighted by studies of steroid 5α-reductase deficient individuals who have vestigial prostate glands and do not suffer from acne vulgaris or male pattern baldness (see McGinley, J. et al., The New England J. of Medicine, 300, 1233 (1979)). Thus, inhibition of the conversion of testosterone to DHT in these target tissues is anticipated to be useful in the treatment of a variety of androgen responsive diseases, e.g., benign prostatic hyperplasia, prostate cancer, acne, male pattern baldness, and hirsutism. Additionally, it has recently been discovered that two isozymes of 5α-reductase exist in humans which differ in their tissue distribution, affinity for testosterone, pH profile and sensitivity to inhibitors (see Russell, D.W. et al., J. Clin. Invest, 89, 293 (1992); Russell, D.W. et al., Nature, 3.54, 159 (1991 )). The steroid 5α- reductase deficient individuals studied by Imperato-McGinley are deficient in the type 2, 5α-reductase enzyme (Russell, D.W. et al., J. Clin. Invest, 90, 799 (1992); Russell, D.W. et al., New England J. Med, 327, 1216 (1992)), which is the predominant isozyme present in the prostate, while the type 1 isozyme is predominant in the skin. The relative value of isozyme specific and dual inhibitors of the two isozymes of 5α-reductase will depend upon the type of disease treated (benign prostatic hyperplasia, prostate cancer, acne, male pattern baldness, or hirsutism) as well as the stage of the disease (prevention versus treatment) and the anticipated side-effects in the intended patients (for example treatment of acne vulgaris in pubescent males). Because of their valuable therapeutic potential, testosterone 5α-reductase inhibitors [hereinafter "5α-reductase inhibitors"] have been the subject of active research worldwide. For example, see: Hsia, S. and Voight, W., J. Invest. Derm., 62, 224 (1973); Robaire, B. et al., J. Steroid Biochem., 8, 307 (1977); Petrow, V. et al., Steroids, 38, 121 (1981 ); Liang, T. et al., J. Steroid Biochem., 19, 385 (1983); Holt, D. et al., J. Med. Chem., 33, 937 (1990); U.S. Patent No. 4,377,584, U.S. Patent No. 4,760,071 and U.S. Patent No. 5,017,568. Two particularly promising 5α-reductase inhibitors are MK-906 (Merck), known by the generic name, finasteride, and marketed under the trademark, Proscar; and SKF-105657 (SmithKline Beecham), shown in Scheme B. finasteride SCHEME B The potent inhibition of bovine adrenal and porcine granulosa cell 3β-hydroxy- Δ 5 -steroid dehydrogenase / 3-keto-Δ 5 -steroid isomerase (3βHSD) by the 4- azasteroid derivative, 4-MA, shown in Scheme C and not by the drug finasteride (Tan, C.H.; Fong, C.Y.; Chan, W.K. Biochem. Biophys. Res. Comm., 144, 166 (1987) and Brandt, M.; Levy, M.A. Biochemistry, 28, 140 (1989)) along with the critical role of 3βHSD in steroid biosynthesis (Potts, G.O. et al., Steroids, 32, 257 (1978)), suggests that optimal inhibitors of type 1 and 2 5α-reductase should also be selective versus human adrenal 3βHSD. SCHEME C The importance of selectivity in 5α-reductase inhibitors has been emphasized by reports of hepatotoxicity in certain 4-azasteroids such as 4-MA (McConnell, J.D. The Prostate Suppl., 3, 49 (1990) and Rasmusson, G.H. et al. J. Med. Chem. , 27, 1690 (1984)). SUMMARY OF THE INVENTION One aspect of the present invention are the compounds of formula (I), wherein R 1 and R 2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R 1 and R 2 is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is, hydrogen, -Alk 1 -H (optionally substituted with one or more halogens), lower cycloalkyl, lower cycloalkyl-lower alkyl), halogen, -(Alk 1 ) n -C02H, -(Alk ) n -C0 2 R 7 . -(Alk1) n -Ar , -(Alk ) n -CONR8R9, -(Alk 1 ) n -NR8R9, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -CN, -(Alk )-OH, -(Alk ) n -COR 7 ; or -(Alk 1 ) n -OR 7 ; wherein Alk 1 is lower alkylene, lower alkenylene or lower alkynylene, n is O or 1 , r is O, 1 or 2, R 7 is -Alk 1 -H, -(Alk 1 ) n -Ar 1 or lower cycloalkyl, R8 and R^ are independently hydrogen, -Alk 1 -H or lower cycloalkyl, Ar 1 is a homocyclic aryl group of 6 to 14 carbons; R 4 is, hydrogen, -Alk 1 -H, lower cycloalkyl, lower cycloalkyl-lower alkyl, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -phthalimidyl, -(Alk 1 )-C0 2 H, -(Alk ) n -C0 2 R 7 -(Alk ) n -COR 7 > -(Alk 1 )n-Ar 1 , -(Alk 1 ) n -CONR8R9, -(Alk 1 ) n -NR8R9, -(Alk 1 ) n -OH or -(Alk 1 ) n -OR 7 ; X is, (CR ,0 R 11 ) P (CR 12 R 13 ) / wherein R 1 °, R 1 1 , R 12 and R 1 3 are independently hydrogen or lower alkyl, p and q are independently either 0 or 1 ; and, i) Y is hydrogen or hydroxy and Z is -(Alk ) n -COR 5 , -(Alk 2 ) n -C0 2 R 5 , -(Alk 2 ) n -COSR5, -(Alk 2 ) n -CONR 1 4R 5,-(Alk )-OC02R 5 ,-(Alk 2 )-OCOR5. -(Alk2)-OCONR 1 4Rl5 t .(Alk )-OR5, -(Alk 2 )-NR5'COR5, -(Alk 2 )-NR5'C0 2 R 5 , -(Alk 2 )-NRδC0NR 1 4R15, -(Alk 2 ) n -CONR5NR 1 4R15 ; -(Alk 2 ) n -CONR 5 CONR R 15 , -(Alk )-NR 5 CSNR 1 4 R 1 5 or -(Alk 2 ) n -CONRδCSNR 4 R 1 5 ; wherein Alk 2 is (C1-12) alkylene, (C2-12) alkenylene or (C2-12) alkynylene, R 5 and R 5 ' are independently hydrogen, -Alk 1 -H (optionally substituted independently with one or more CO2H, CO2R 7 , Ar 2 , Ar 3 or cyano groups) -(Alk 1 ) n -(lower cycloalkyl (optionally substituted independently with one or more -Alk 1 -H groups)), adamantyl, norbornyl, Ar 2 , Ar 3 , (lower cycloalkyl)-Ar 2 or (lower cycloalkyl)-Ar 3 ; • wherein Ar 2 is a homocyclic aromatic group of 6 to 14 carbon ring atoms (optionally substituted independently with one or more -Alk 2 -H (optionally substituted independently with one or more halogens), -(Alk 1 ) n COR 7 - -(Alk 1 ) n -OH, -(Alk 1 ) n -OR 16 , -(Alk 1 ) n -Ar 3 , -(Alk 1 ) n -C0 2 H, -(Alk1) n -C0 2 R 7 , S(0) r R 7 , NR 8 S(0) r R 16 , NR8R9, CONR8R9, lower cycloalkyl, lower alkoxy, -(Alk 1 ) n -Ar 1 (optionally substituted with one or more -Alk -H or halogen), methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogens); wherein R 16 is -Alk -H (optionally substituted independently with one or more halogens), lower cycloalkyl (optionally substituted independently with one or more halogens, or -Alk 1 -H (optionally substituted independently with one or more halogens)) or -(Alk 1 ) n -Ar 1 (wherein Ar 1 is optionally substituted independently with one or more, lower alkoxy, cyano groups, halogens or -Alk 1 -H (optionally substituted independently with one or more halogens)); Ar 3 is an aromatic group of 5 to 14 ring atoms, at least one of which is O, N or S, (optionally substituted independently with one or more -Alk 1 -H (optionally substituted independently with one or more halogens), lower cycloalkyl, lower alkoxy, CO2H, CO2R 7 , -(Alk 1 ) n -Ar 1 , cyano or halogen); R 14 and R 1 . 5 are, a) independently, hydroxy, hydrogen, -Alk 2 - H, lower alkoxy, -(Alk 1 ) n -adamantyl, -(Alk 1 ) n -myrantyl, -(Alk 1 ) n -norbomyl, -(Alk 1 ) n -fluorenyl, -(Alk 1 ) n -fluorenonyl, -(Alk 1 ) n -indanyl (optionally substituted with one or more -Alk 1 - H), -Alk 1 - H (optionally substituted independently with one or more, halogens, cyano, cycloalkyl, SR 5 , COR 5 , CONR 5 R 7 , NR 5 'COR 5 , NR 5 'C0 2 R 5 , NR 5 'CONHR 5 , CO2R 5 , OR 5 , Ar 2 or Ar 3 ), Ar 2 or Ar 3 or a saturated C4-18 bicyclic ring or C3-11 saturated ring, optionally containing an oxygen or sulfur atom (said rings optionally substituted independently with one or more cyano, R 1 6, Ar 2 , Ar 3 ); b) alkylene groups (optionally substituted with one or more R 7 groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocyclic group) wherein; Het represents -0-, -CH2-, -S(0) r> -(NH)- or -(N(Alk 1 -H))-; with the proviso that when Z is -(Alk ) n -COR 5 , -(Alk 2 ) n -C0 2 R 5 or -(Alk ) n -CO-thiopyridyl and R 5 is hydrogen, -Alk 1 -H, lower cycloalkyl, or adamantyl or when Z is -(Alk 2 ) n -CONR 1 R 15 and R 1 and R 15 are a) independently hydrogen, -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, - Ar 1 , benzyl, diphenylmethyl, triphenylmethyl or -(Alk 1 ) n -norbornyl; or b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocylic ring as herein before defined, Y is hydroxy; or ii) Y is hydrogen and Z is OR 5 , OCOR 5 , OCONR 14 R 15 , NRS'COR 5 , NR 5 'C0 2 R 5 . NR 5 CONR 14 R 15 or NR 5 CSR 1 4 R 15 ; and iii) Y and Z taken together are =0, =CH-(Alk 1 ) n -COR 5 , =CH-(Alk 1 ) n -C0 2 R 5 or =CH-(Alk 1 ) n -CONR 4 R 15 ; R 6 is, hydrogen or methyl; and pharmaceutically acceptable salts thereof. Other aspects of the invention are: 1. A method of inhibiting testosterone-5α-reductases comprising contacting testosterone-5α-reductases with a compound of formula (I). 2. A method of treatment of androgen responsive or mediated disease com¬ prising administering an effective amount of a compound of formula (I) to a patient in need of such treatment. 3. Pharmaceutical formulations containing a compound of formula (I) as an active ingredient. Novel chemical intermediates used in the synthesis, as taught herein, of the compounds of formula (I) are also within the scope of the present invention. 4. A method of treatment of androgen responsive or mediated disease com¬ prising administering an effective amount of a compound of formula (I) to a patient in need of such treatment in combination with an antiandrogen such as flutamide. 5. A method of treatment of benign prostatic hyperplasia comprising adminis¬ tering an effective amount of a compound of formula (I) to a patient in need of such treatment in combination with an alpha 1 adrenergic receptor blocker (e.g. terazosin). 6. A method of treatment of benign prostatic hyperplasia comprising adminis¬ tering an effective amount of a compound of formula (I) to a patient in need of such treatment in combination with an anti-estrogen. DETAILED DESCRIPTION OF THE INVENTION As used herein the term "lower" in reference to alkyl and alkoxy means 1-6 carbons, straight or branched chain, e.g., methyl, ethyl, propyl, butyl, pentyl and hexyl; and methoxy, ethoxy, propoxy, butoxy, pentoxy and hexoxy respectively. in reference to alkenyl or alkynyl "lower" means 2-7 carbons, straight or branched chain e.g., ethenyl, propenyl, butenyl, pentenyl and hexenyl; and ethynyl, propynyl, butynyl, pentynyl and hexynyl respectively. In reference to cycloalkyl "lower" means 3-7 carbons, i.e., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl, preferably 3-6 carbons. The term "lower cycloalkyl-lower alkyl" means a lower alkyl bearing a lower cycloalkyl, e.g., cyclopropyl methyl which may also be named methylene-cyclopropyl. Preferably "-Alk 2 -" is the same as "-Alk 1 ". The term "alkanoyl of 2-6 carbons" refers to alkyl, straight or branched, carboxylic acid groups with a total of 2-6 carbons attached to the structure of formula (I) at a carbon of the alkyl portion of the group, e.g., -CH2COOH, - (CH 2 )2COOH, -(CH 2 )3COOH, -(CH 2 COOH and -(CH 2 )5COOH. The term "halogen" means fluoro, chloro, bromo and iodo moieties. Where -(Alk 1 )-H is optionally substituted with one or more halogens, the fluoro moiety is preferable, e.g., trifluoromethyl. The term "aromatic group" includes, but is not limited to, phenyl, napthyl, anthryl, thiophenyl, isothiazolyl, pyrrolyl, imidazolyl, oxazolyl, isoxaolyl, quinolyl, isoquinolyl, indanyl, pyridyl and furyl. The term "aryl" means homocylic aromatic groups having 6 to 14 carbons, e.g., phenyl, naphthyl and anthryl. Where R 1 4 and R 1 5 are carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen form a 4 to 8 atom heterocyclic group, such groups which may be formed include, but are not limited to, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, morpholinyl or thiomorpholinyl each optionally substituted with one or more lower alkyl groups. Examples of C3-11 saturated rings containing an oxygen or sulfur atom include, but are not limited to tetrahydropyran and tetrahydrothiopyran. An example of a saturated C4-18 bicyclic ring is bicyclononyl. Unless specified otherwise, attachment of heteroaromatic or non-aromatic heterocyclic groups containing nitrogen and/or sulfur may be through any carbon or nitrogen. However, if the heterocyclic group is non-aromatic, the preferred position of attachment is through the nitrogen. Further, if the group is a six member, hetero-aromatic ring, attachment through a carbon atom is preferred. Preferably R 3 is hydrogen, halogen, lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl, especially hydrogen, halogen or lower alkyl. R 4 is preferably hydrogen, lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl, especially hydrogen or lower alkyl. X is preferably -CH2-. Preferably Y is hydrogen and Z is -(Alk ) n -COR 5 , -(Alk ) n -CONR 14 R 5 , - (Alk 2 )-OCθ2R 5 , - (Alk 2 )-OCOR 5 , -(Alk )-NR 5 'COR 5 , -(Alk 2 ) n - CONR 5 NR 14 R 15 , -(Alk )-NR 5 CONR 4 R 1 5 , or -(Alk 2 ) n -CONR 5 CONR 1 R 15 , especially -COR 5 , -CONR 14 R 1 5 , -CH2OCO2R 5 , -CH2OCOR 5 , -CH2NR 5 'COR 5 , -CONR 5 NR R 1 5 , -CH2NR 5 CONR R 15 or -CONR 5 CONR 4 R 1 5 . Compounds wherein Y is hydrogen and Z is -CONR 14 R 15 are particularly of interest. Ar 1 is preferably a phenyl group, and Ar 2 is preferably a phenyl group optionally substituted independently with one or more -Alk 2 -H (optionally substituted independently with one or more halogens), -OR 16 , -S(0)rR 7 , Ar 1 , methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogen groups. Preferably R 14 is hydrogen or hydroxy, and R 15 is hydrogen, lower cycloalkyl (optionally substituted independently with one or more R 7 or Ar 2 groups), - (Alk 1 )-adamantyl, -(Alk 1 ) n -myrantyl, -(Alk 1 ) n -norbomyl, -(Alk 1 ) n -fluorenyl, - (Alk 1 )n-indanyl, -Alk 1 -H (optionally substituted independently with one or more lower cycloalkyl, SR 5 , OR 5 , Ar 2 or Ar 3 groups), Ar 2 or Ar 3 ; or R 1 4 and R 1 are carbon atoms, optionally substituted with one or more R 7 groups, taken together with the linking nitrogen to form a 5 to 7 atom heterocyclic group — N Het wherein Het represents -CH2-. Preferably Ar 3 is an aromatic group of five or six ring atoms, at Teast one of which is O, N or S, optionally substituted independently with one or more Alk 1 H groups, especially optionally substituted pyrrolyl, thienyl, furyl and pyridyl groups. R 5 is preferably hydrogen, lower alkyl optionally substituted independently with one or more Ar 2 groups, (lower alkyl) n -lower cycloalkyl, menthyl, adamantyl, norbornyl or Ar 2 . A particular group of the compounds of formula (I) are the compounds wherein: R 1 and R 2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R 1 and R 2 is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is, hydrogen, -Alk 1 -H (optionally substituted with one or more halogens), lower cycloalkyl, lower cycloalkyl-lower alkyl), halogen, -(Alk 1 ) n -Cθ2H, -(Alk 1 ) n -C0 2 R 7 . -(Alk 1 ) n -Ar 1 , -(Alk 1 ) n -CONR8R9, -(Alk ) n -NRδR9 ( -(Alk ) n -S(0) r R 7 , -(Alk CN, -(Alk 1 )-OH, -(Alk ) n -COR 7 ; or -(Alk 1 ) n -OR 7 ; wherein Alk 1 is lower alkylene, lower alkenylene or lower alkynylene, n is 0 or 1 , r is O, 1 or 2, R 7 is -Alk 1 -H, -(Alk 1 ) n -Ar 1 or lower cycloalkyl, R and R 9 are independently hydrogen, -Alk 1 -H or lower cycloalkyl, Ar 1 is a homocyclic aryl group of 6 to 14 carbons; R 4 is, hydrogen, -Alk 1 -H, lower cycloalkyl, lower cycloalkyl-lower alkyl, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -phthalimidyl, -(Alk 1 )-C0 2 H, -(Alk ) n -C0 2 R 7 , -(Alk 1 ) n -COR « -(Alk 1 ) n -Ar 1 , -(Alk 1 ) n -CONR8R9, -(Alk 1 ) n -NR8R9, -(Alk ) n -OH or-(Alk 1 ) n -OR 7 ; Xis, (CR 10 R 11 ) P (CR 12 R 13 ) C / wherein R 1 °, R 11 , R 12 and R 13 are independently hydrogen or lower alkyl, p and q are independently either 0 or 1 ; and, i) Y is hydrogen or hydroxy and Z is -(Alk 2 ) n -COR 5 , -(Alk 2 ) n -C0 2 R 5 . -(Alk 2 ) n -COSR 5 , -(Alk ) n -CONR 1 R 5 ,-(Alk 2 )-OCθ2R 5 ,-(Alk )-OCOR 5 , -(Alk 2 )-OCONR 1 R 15 , -(Alk 2 )-OR 5 , -(Alk 2 )-NR 5 'COR 5 , -(Alk 2 )-NR 5 'C0 2 R 5 , -(Alk 2 )-NR 5 CONR R 15 , -(Alk ) n -CONR 5 NR 1 R 15 , -(Alk 2 ) n -CONR 5 CONR 4 R 15 , -(Alk 2 )-NR 5 CSNR 4 R 15 or -(Alk 2 ) n -CONR 5 CSNR 14 R 15 ; wherein Alk 2 is (Cι_i2) alkylene, (C-2-12) alkenylene or (C2-12) alkynylene, R 5 and R 5 ' are independently hydrogen, -Alk 1 -H (optionally substituted independently with one or more CO2H, CO2R 7 , Ar 2 , Ar 3 or cyano groups) -(Alk 1 ) n -(lower cycloalkyl (optionally substituted independently with one or more -Alk 1 -H groups)), adamantyl, norbornyl, Ar 2 , Ar 3 , (lower cycloalkyl)-Ar 2 or (lower cycloalkyl)-Ar 3 ; wherein Ar 2 is a homocyclic aromatic group of 6 to 14 carbon ring atoms (optionally substituted independently with one or more -Alk 2 -H (optionally substituted independently with one or more halogens), -(Alk 1 ) n -OH, -(Alk 1 ) n -OR 1 6 , -(Alk 1 ) n -Ar 3 , -(Alk 1 ) n -C0 2 H, -(Alk 1 ) n -C0 2 R 7 . S(0) r R 7 , NR8S(0) r R 16 , NR 3 R9, CONR8R9, lower cycloalkyl, lower alkoxy, -(Alk 1 ) n -Ar 1 , methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogens); wherein R1 6 is -Alk 1 -H (optionally substituted independently with one or more halogens), lower cycloalkyl (optionally substituted independently with one or more halogens, or -Alk 1 -H (optionally substituted independently with one or more halogens)) or -(Alk 1 ) n -Ar 1 (wherein Ar 1 is optionally substituted independently with one or more, lower alkoxy, cyano groups, halogens or -Alk -H (optionally substituted independently with one or more halogens)); Ar 3 is an aromatic group of 5 to 14 ring atoms, at least one of which is O, N or S, (optionally substituted independently with one or more -Alk 1 -H (optionally substituted independently with one or more halogens), lower cycloalkyl, lower alkoxy, CO2H, CO2R 7 , -(Alk 1 ) n -Ar 1 , cyano or halogen); R 14 and R 1 5 are, a) independently, hydroxy, hydrogen, -Alk 2 - H, lower cycloalkyl (optionally substituted independently with one or more cyano, R 16 , Ar 2 , Ar 3 ), lower alkoxy, -(Alk 1 ) n -adamantyl, -(Alk 1 ) n -myrantyl, -(Alk 1 ) n -norbomyl, -(Alk 1 ) n -fluorenyl, -(Alk 1 ) n -indanyl, -Alk 1 - H (optionally substituted independently with one or more, halogens, cyano, cycloalkyl, SR 5 , COR 5 , CONR 5 R 7 , NR 5 'COR 5 , NR 5 'C0 2 R 5 , NR 5 'CONHR 5 , C0 2 R 5 , OR 5 , Ar 2 or Ar 3 ), Ar 2 or Ar 3 ; b) alkylene groups (optionally substituted with one or more R 7 groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocyclic group) wherein; Het represents -0-, -CH2-, -S(0) r , -(NH)- or -(N(Alk 1 -H))-; with the proviso that when Z is -(Alk 2 ) n -COR 5 , -(Alk ) n -C0 2 R 5 or -(Alk ) n -CO-thiopyridyl and R 5 is hydrogen, -Alk 1 -H, lower cycloalkyl, -(Alk 1 ) n -Ar 1 , adamantyl or when Z is -(Alk 2 ) n -CONR 14 R 15 and R 14 and R 5 are a) independently hydrogen, -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, - Ar 1 , benzyl, diphenylmethyl, triphenylmethyl or -(Alk 1 ) n -norbomyl; or b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocylic ring as herein before defined, Y is hydroxy; or ii) Y is hydrogen and Z is OR 5 , OCOR 5 , OCONR 4 R 1 5 , NR 5 'COR 5 , NR 5 'C0 2 R 5 , NR 5 CONR 14 R 15 or NR 5 CSR 14 R 15 ; and iii) Y and Z taken together are =0, =CH-(Alk 1 ) n -COR 5 , =CH-(Alk 1 ) n -C0 2 R 5 or =CH-(Alk ) n -CONR 14 R 15 ; R 6 is, hydrogen or methyl; and pharmaceutically acceptable salts thereof. A subgroup of the compounds of formula (I) are the compounds wherein: R 1 and R 2 are, i) independently hydrogen or lower alkyl and the bond between the carbons bearing R 1 and R 2 is a single or a double bond, or ii) taken together are a -CH2- group to form a cyclopropane ring, and the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is hydrogen, -Alk 1 -H, -Alk 1 -H substituted with one or more halogens, lower cycloalkyl, lower cycloalkyl-lower alkyl, halogen,-(Alk 1 ) n -C0 2 H, -(Alk 1 ) n -C0 2 R 7 , -(Alk 1 ) n -Ar 1 , -(Alk 1 ) n -CONR8R9, -(Alk ) n -NR8R9, -(Alk 1 ) n -S(0) r R 7 , -(Alk ) n -CN, -(Alk 1 )-OH or -(Alk 1 ) n -OR 7 ; wherein Alk 1 is lower alkylene, lower alkenylene or lower alkynylene, n is 0 or 1 , r is O, 1 or 2, R 7 is -Alk 1 -H, -(Alk 1 ) n -Ar 1 or lower cycloalkyl, R 8 and R 9 are independently hydrogen, -Alk 1 -H or lower cycloalkyl, Ar 1 is a homocyclic aryl group of 6 to 14 carbons; R 4 is hydrogen, -Alk 1 -H, lower cycloalkyl, lower cycloalkyl-lower alkyl, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -phthalimidyl, (-Alk 1 -)C0 2 H, -(Alk 1 ) n -Cθ2R 7 , -(Alk ) n -Ar 1 , -(Alk 1 ) n -CONR8R9, -(Alk 1 ) n -NR8R9, -(Alk 1 ) n -OH or -(Alk 1 ) n -OR 7 ; X is, wherein R 1 0 , R 1 1 , R 1 2 and R 1 3 are independently hydrogen or lower alkyl, p and q are independently either 0 or 1 ; Y and Z are, i) Y is hydrogen or hydroxy and Z is -(Alk ) n -COR 5 , -(Alk 2 ) n -C0 R 5 , -(Alk 2 ) n -COSR 5 , -(Alk 2 ) n -CONR 14 R 15 , -(Alk 2 )-OCOR 5 , -(Alk 2 )-OCONR 4 R 15 , -(Alk 2 )-OR 5 , -(Alk 2 )-NR 5 COR 5 , -(Alk )-NR 5 C0 2 R 5 , -(Alk 2 )-NR 5 CONR 1 R 15 , -(Alk 2 )- n CONR 5 NR 14 R 1 5 , -(Alk 2 ) n -CONR 5 CONR 1 R 15 , (-Alk -)NR 5 CSNR 14 R 1 5 or -(Alk 2 ) n -CONR 5 CSNR 1 R 15 ; wherein Alk 2 is (C1-12) alkylene, (C2.12) alkenylene or (C2-12 alkynylene, R 5 is hydrogen, -Alk 1 -H, -(Alk 1 ) n -(lower cycloalkyl), adamantyl, -(Alk 1 ) n -Ar 2 , -(Alk 1 ) n -Ar 3 , (lower cycloalkyl) n Ar 2 , (lower cycloalkyl) n Ar 3 or -Alk 1 - substituted independently with one or more CO2H, CO2R 7 , Ar 2 or Ar 3 groups; wherein Ar 2 is an aromatic group of 6 to 14 carbon ring atoms, optionally substituted with one or more Alk 1 , Alk 1 substituted with one or more halogens, -(Alk 1 ) n -OH, -(Alk 1 ) n -OR 7 , -(Alk 1 ) n -C0 2 H, -(Alk 1 ) n -C0 2 R 7 , S(0) r R 7 or NR8R9, lower cycloalkyl, lower alkoxy, -(Alk 1 ) n -Ar 1 , methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano or halogen groups; Ar 3 is an aromatic group of 5 to 14 ring atoms, at least one of which is O, N or S, optionally substituted with one or more Alk 1 , lower cycloalkyl, lower alkoxy, CO2H, CO2R 7 , -(Alk 1 ) n -Ar 1 , cyano or halogen groups; R 14 and R 15 are, a) independently, hydrogen or -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, -(Alk 1 ) n -norbomyl, Ar 2 , Ar 3 , -Alk 1 - substituted independently with one or more, SR 5 , COR 5 , CONR 5 R 7 , NR 5 COR 5 , NR 5 C0 2 R 5 , NR 5 CONHR 5 CO2R 5 , OR 5 , Ar 2 or Ar 3 groups, -(Alk 1 ) n -fluorenyl, or -(Alk 1 ) n -indanyl; or b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocyclic group — N Het wherein; Het represents -O-, -CH 2 -, -S(0) r , -(NH)- or -(N(Alk 1 ))-; with the proviso that when Z is (-Alk 2 -) n COR 5 , (-Alk 2 -) n C02R 5 or -(Alk 2 ) n -CO-thiopyridyl and R 5 is hydrogen, -Alk 1 -H, lower cycloalkyl, -(Alk 1 ) n -Ar 1 , adamantyl or when Z is (-Alk 2 -) n CONR 1 R 15 and R 4 and R 15 are (a) independently hydrogen, -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, -Ar 1 , benzyl, diphenylmethyl, triphenylmethyl or -(Alk 1 ) n -norbornyl; or (b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocylic ring as herein before defined, Y is hydroxy; ii) Y is hydrogen and Z is OR 5 , OCOR 5 , OCONR 1 R 15 , NR 5 COR 5 , NR 5 C0 2 R 5 , NR 5 CONR 14 R 15 or NR 5 CSR R 15 ; iii) Y and Z taken together are =0, =CH-(Alk 1 ) n -COR 5 , =CH-(Alk 1 ) n -C0 2 R 5 or =CH-(Alk 1 ) n -CONR 4 R 15 ; R 6 is hydrogen or methyl; and pharmaceutically acceptable salts thereof. Particular groups of compounds of formula (I) are the compounds of formulas (IA), (IB), (IC) and (ID) (IA) (1B) (1C) (1D) Compounds of formula (IA) are especially of interest. In an alternative aspect the invention provides compounds of formula (I) wherein Z is -COR 5 including: 17β— (1 -Oxo-2-cyclohexylethyl)-6-azaandrost-4-en-3-one 17β-(1 -Oxo-1 -(2,4-dif luorophenyl)methyl)-6-azaandrost-4-en-3-one 17β-(1 -Oxo-1 -(4-isopropoxyphenyl)methyl)-6-azaandrost-4-en-3-one 17β— (1 -Oxo-3,3-diphenylpropyl)-6-azaandrost-4-en-3-one 17β— (1 -Oxo-1 -(2-norbornyl)methyl)-6-azaandrost-4-en-3-one A particular aspect of the invention provides compounds of formula (I) wherein Z is -CONR 14 R 15 , R 14 is hydrogen and R 15 is Ar 2 or C3.11 saturated ring, optionally containing an oxygen or a sulfur atom, (optionally substituted independently with one or more R 7 or Ar 2 groups). Preferably R 15 is a group of formula Ar 2a R- R' " i, (-Ar ) R k wherein R a and R are independently hydrogen, lower alkyl, trifluoromethyl, halogen or phenyl (optionally substituted with one or more halogens or branchedC4-7 alkyl) and R c is hydrogen or one or more halogens, or R 15 is a C3_.11 saturated ring, optionally containing an oxygen or a sulfur atom, substituted with a group of formula Ar 2a . In a particular group of compounds Ar 2a is a group of formula Ar 2aa where R aa is branchedC4-7 alkyl, trifluoromethyl or phenyl optionally substituted with one or more halogens; one of R ba and R 03 is branched C4-7alkyl, trifluoromethyl, halogen or phenyl optionally substituted with one or more halogens, and the other is hydrogen or halogen; and R da is hydrogen or halogen. Particular compounds of the invention include : 17β-N-((2,6-Di-Apropyl)phenyl)-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,4,6-trimethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Chloro-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-(2,6-Dimethyl-4-bromo)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Dimethyl-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Dibromo-4-isopropyl)phenyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-(2,5-Ditrif!uoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Diethyl-3,5-dichloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Diethyl-3-chloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,4,6-Trichloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Bromo-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-(2-f-Butyl-6-methyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1 -(4-Chlorophenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Dibromo-4-chloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17f^N-(2,6-Diethyl-4-bromo)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Bromo-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Chloro-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(5-Bromo-2-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en 7 3-one 17β-N-(5-Chloro-2-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Diethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(4-Bromo-2-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl-5-cyano)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-(0-4-Tolyl)-5-trif luoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-(2-(0-4-Chlorophenyl)-5-trifluoromethyl)phenyl-carbamoyl-6- azaandrost-4-en-3-one 17β-N-(2-Nitro-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-(0-Phenyl)-5-(1 ,1 -dimethyl)propyl)phenyl-carbamoyl-6-azaandrost-4- en-3-one 17β-N-(2-Ethylsulfonyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4- en-3-one 17β-N-(3,5-Di-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl-5-phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Di-/-propyl)phenyl-carbamoyl-6-azaandrost-1 ,4-dien-3-one 17β-N-(2,6-Di- -propyl)phenyl-carbamoyl-6-azaandrost-4-methyl-1 ,4-dien-3- one 17β-N-1 -(4-Trif luoromethylphenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-1-(4-Fluorophenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1 -(4-Methoxyphenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1 -(4-Methoxyphenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,5-bis(Trifluoromethyl))phenyl-carbamoyl-6-azaandrost-4-methyl-4-en- 3-one 17β-N-(2-t-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-methyl-4- en-3-one 17β-N-(2,5-Di-t-butyl)phenyl-carbamoyl-6-azaandrost-4-methyl-4-en-3-one 17β-N-(2-t-Butyl-5-(4-chlorophenyl))phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1 -(4-t-Butylphenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-t-Butylphenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-Chlorophenyl)cyclopentyl-carbamoyl-6-azaandrost-4-methyl-4-en-3- one 17β-N-(2,5-bis(Trifluoromethyl))phenyl-carbamoyl-6-azaandrost-4-chloro-4-en- 3-one 17β-N-(2-f-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-chloro-4- en-3-one 17β-N-1 -(4-f-Butylphenyl)cycloheptyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-f-Butylphenyl)cyclohexyl-carbamoyl-6-azaandrost-4-chloro-4-en-3- one 17β-N-(2,6-Diethyl-4-(4-chlorophenyl))phenyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-4-(4-f-Butylphenyl)tetrahydrothiopyranyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-9-(4-f-Butylphenyl)bicyclo[3.3.1]nonyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-4-(4-f-Butylphenyl)tetrahydropyranyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1 -(4-Chlorophenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl-5-(4-f-butyl)phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one or 17β-N-1-(4-Chlorophenyl)cyclopentyl-carbamoyl-6-azaandrost-4-chloro-4-en- en-3-one and pharmaceutically acceptable salts thereof. A particular compound is 17β-N-(2-f-Butyl-5-trifluoromethyl)phenyl-carbamoyl- 6-azaandrost-4-en-3-one and pharmaceutically acceptable salts thereof. One particular aspect of the invention provides compounds of formula (I) wherein R 1 and R 2 are as hereinbefore defined, R 3 is hydrogen or lower alkyl; R 4 is hydrogen or lower alkyl; Y is hydrogen; and Z is -COR 5 , -CONR 14 R 15 , -CH 2 OC0 2 R 5 , -CH 2 OCOR 5 , -CH 2 NR 5' COR 5 , - CONR 5 NR 14 R 15 , -CH 2 NR 5 CONR 1 R 5 , or -CON 5 CONR 1 R 15 wherein R 5 and R 5' are independently hydrogen, lower alkyl optionally substituted independently with one or more Ar 2 groups (lower alkyl) n -lower cycloalkyl, menthyl, adamantyl, norbornyl or Ar 2 ; Ar 2 is a phenyl group optionally substituted independently with one or more - Alk-H (optionally substituted independently with one or more halogens), -OR 16 , -S(0) r R 7 , phenyl, methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogen groups; Alk is lower alkylene, lower alkenylene or lower alkynylene; n is O or l ; r is O, 1 or 2; R 7 is -Alk-H, -(Alk)n-phenyl or lower cycloalkyl; R 16 is -Alk-H (optionally substituted independently with one or more halogens), lower cycloalkyl (optionally substituted independently with one or more halogens or -Alk-H (optionally substituted independently with one or more halogens)) or -(Alk) n -phenyl (wherein phenyl is optionally substituted independently with one or more lower alkoxy, cyano, halogen or -Alk-H groups (optionally substituted independently with one or more halogens)); R 14 is hydrogen or hydroxy, and R 5 is hydrogen, lower cycloalkyl (optionally substituted independently with one or more R 7 or Ar 2 groups), -(Alk)-adamantyl, -(Alk)n-myrantyl, -(Alk) n -norbomyl, -(Alk) n -fluorenyl, -(Alk) n -indanyl. -Alk-H (optionally substituted independently with one or more lower cycloalkyl, SR 5 , OR 5 , Ar 2 or Ar 3 groups), Ar 2 or Ar 3 , or R 14 and R 15 taken together with the linking nitrogen form a pyrrolidinyl, piperidinyl or perhydroazepinyl ring optionally substituted with one or more R 7 groups; Ar 3 is a pyrrolyl, thienyl, furyl or pyridyl group optionally substituted independently with one or more Alk-H groups; with the provisos that when Z is COR 5 , R 5 is substituted lower alkyl, lower alkyl lower cycloalkyl, menthyl, norbornyl or Ar 2 ; when Z is CONR 14 R 15 and R 15 is hydrogen, -Alk-H, lower cycloalkyl, lower alkoxy, adamantyl, phenyl, benzyl, diphenylmethyl, triphenylmethyl or -(Alk) n - norbornyl, R 14 is hydroxy; and when Z is CONR 14 R 15 and R 14 and R 15 taken together with the linking nitrogen form a pyrrolidinyl, piperidinyl or perhydroazepinyl ring, said ring is substituted with one or more lower alkenyl, lower alkynyl, -(Alk)n-phenyl or lower cycloalkyl groups; and pharmaceutically acceptable salts thereof. Compounds of formula (IA) are especially of interest. In a still further aspect of the invention of partiucalr interest, Z is CONR 14 R 15 . Some of the substituents of the compound of formula (I) may cause asymmetry about the atoms to which they are attached giving rise to either α or β stereochemical configuration. (For a detailed explanation of stereochemical configuration see March, J. Advanced Organic Chemistry, 3rd Ed., ch 4, John Wiley & Sons, New York (1985).) Unless otherwise indicated, either the α and β stereo configurations are intended for the substituents. The compounds of formula (I) can be used in the form of an acid addition salt derived from inorganic or organic acids. Where the salt of a compound of formula (I) is to be used for a human or veterinary medicinal application the salt must be pharmaceutically acceptable. However, non-pharmaceutically acceptable salts of the compounds of formula (I) may be useful as intermediates in the preparation of a corresponding pharmaceutically acceptable salt. Pharmaceutically acceptable salts include, but are not limited to, salts with inorganic acids such as hydrochloride, sulfate, phosphate, diphosphate, hydrobromide and nitrate salts or salts with an organic acid such as the acetate, malate, maleate, fumarate, tartrate, succinate, citrate, lactate, methanesulfonate, p-toluenesulfonate, palmitoate, salicylate and stearate salts. Preparation of Compounds According to one general process (A) the compounds of the present invention may be prepared by the procedure shown in step 8 of Scheme I, wherein R 1 - R 4 , R 6 , Y and Z are as defined for formula (I) and "JO" is a protected hydroxy group: SCHEME SCHEME I (continued) In Step 1 of Scheme I when Z is CO2H, the acid group at the 17 position of a compound of formula (II) is converted to the corresponding ketone, ester or amide of compound (III) accompanied by deprotection of the hydroxy group at the 3 position. Alternatively a compound of formula (III) wherein Z is CO2CH3 and Y is H may be prepared from pregnenolone as described by Rasmusson, et al., J. Med. Chem., 27, 1690 (1984). This may be accomplished by activating the carboxylic acid group toward nucleophilic displacement by treatment with an activating agent such as N,N- bis(2-oxo-3-oxazolidinyl)phosphorinic chloride (BOP-CI) or conversion to the corresponding acid halide group by treatment with a halogenating agent such as oxalyl chloride or thionyl chloride in an aprotic solvent such methylene chloride or toluene at -5 to 1.0°C. The intermediate activated carboxylic acid, e.g., an acid chloride, may be reacted with H-NR 14 R 15 or HOR 5 (wherein R 5 , R 14 and R 1 5 are as defined for formula (I)) at or above room temperature in an aprotic solvent. When R 5 is alkyl, alkenyl, lower cycloalkyl, or adamantyl, the activated acid is treated with R 5 M (wherein M is a metal, such as magnesium or lithium) in a polar, aprotic solvent such as THF or diethyl ether containing catalytic Cul, at a temperature in the range of about 0 to about -78°C. Additionally, when, H-NR 14 R 15 is a hindered, nonnucleophilic aniline the corre- sponding metal salt may be prepared and the activated acid treated with M- NR 14 R 15 (wherein M is a metal, such as magnesium or lithium) in a polar, aprotic solvent such as THF or diethyl ether at a temperature in the range of about 0 to about -78°C. The amines, H-NR 14 R 15 are commercially available or conveniently prepared by methods known in the art. For example, when either R 14 or R 15 is an alkyl or aryl substituted aromatic residue the alkyl group may be introduced as described by Reetz, M.T. et al., Angew. Chem. Int. Ed. Engl., 19, 900 and 901 (1980) or the aryl group introduced as described by Stille, J.K. Pure Appl. Chem., 57, 1771 (1985). When either R 14 or R 15 is an aryl substituted cycloalkyl residue the amine may be prepared by Curtius rearrangement of the corresponding acid, where available, or by the method of He, X. et al., J. Med. Chem., 36,-1188 (1993), i.e. by reacting the corresponding cycloalkanone with the appropriate aryl Grignard reagent followed by conversion of the resulting alcohol to the amine by treatment with sodium azide and trifluoroacetic acid followed by reduction of the azide with lithium aluminum hydride. Aryl substituted cyclopropylamines are prepared by rhodium catalyzed insertion of the appropriate aryl-α-diazo-ester (prepared by the method of Baum, J.S. et al., Synthetic Comm., 17, 1709 (1987)) into the appropriate olefin (as described by Davies, H.W. et al., Tetrahedron Lett., 30, 5057 (1989)) followed by saponification of the ester and Curtius rearrangement of the acid to give the desired amine. In Step 2, a compound of formula (III) is treated with a suitable hydroxy protecting group such as for example a silicon derivative such as a trisubstituted silyl halide, a tetrahydropyran derivative or an arylalkyi group such as a paramethoxybenzyl group. Typically the compound of formula (III) is treated with a trialkylsilyl halide, e.g., triisopropylsilyl chloride, at about 25 to 75°C in an aprotic solvent such as dimethylformamide to protect the hydroxy group in the 3-position to yield the corresponding trisubstituted silylated compound of formula (IV). In Step 3, a compound of formula (IV) is treated with ozone in methanol alone or as a mixture with one or more polar, protic or aprotic solvents, e.g., methylene chloride and methanol, at a temperature substantially below 0°C, e.g., from about -50 to about -80°C to yield a corresponding compound of formula (V). In Step 4, the compound of formula (V) in methanol alone or as a mixture with one or more polar, protic or aprotic solvents, e.g,, methylene chloride and methanol, at about -20°C is treated with a reductant such as zinc and acetic acid then allowed to slowly warm to room temperature to yield the aldehyde of formula (VI). Alternatively the compound of formula (V) may be taken directly to step 5. In Step 5, a compound of formula (V or VI) is reacted with an oxidant, such as Jones reagent (see Bowden, et al., J. Chem. Soc, 39, (1946)) at about 0°C, to yield the corresponding compound of formula (VII). In Step 6, a compound of formula (VII) is converted to an activated carboxylate derivative such as an acid halide, e.g., chloride, by treatment with a halogenating agent, e.g., oxalyl chloride. The resulting acid halide is reacted with an alkali metal azide, e.g., sodium azide, at about 0 to 30°C in an aqueous solvent mixture, such as water and acetone, to yield the corresponding acyl azide compound of formula (VIII). Alternatively, the acid is treated with triphenyl phosphoryl azide in an aprotic solvent such as toluene to yield the acyl azide directly. In Step 7, an acyl azide compound of formula (VIII) is rearranged with ring closure by warming to reflux in an aprotic solvent, such as toluene, to induce rearrangment to the corresponding isocyanate followed by stirring with a weak acid such as silica gel or by reaction with a strong, sterically hindered base, e.g., potassium f-butoxide, in a protic or aprotic solvent at a temperature in the range of about 90 to about 180°C to generate the corresponding compound of formula (IX). -28- Finally, in Step 8 (general process A), the hydroxy function of a compound of formula (IX) is deprotected and oxidized. Thus, in general process (A1) compounds of formula (I) wherein R 4 is hydrogen may be prepared by converting the protected hydroxy group of a compound of formula (IX) to the corresponding hydroxy group, i.e., the hydroxy group is deprotected by conventional means. Thus, for example a trisubstituted silyl group may be removed by reaction with aqueous hydrogen fluoride in a polar solvent such as acetonitrile at about 0°C to room temperature. Next the hydroxy group is oxidized by reaction with a suitable oxidizing agent, for example, with Jones reagent with migration of the double bond to the 4,5 position to generate the corresponding compound of formula (I) where R 4 is hydrogen. Alternatively, in general process (A2) for the preparation of compounds of formula (I), wherein R 4 is an acyl group, the compound of formula (IX) is treated with an acylating agent such as di-f-butyldicarbonate to acylate the 6-nitrogen with migration of the double bond to the 4, 5 position. The hydroxy protecting group is then removed in a conventional manner, for example, a trisubstituted silyl protecting group may be removed with a reagent such as tetrabutylammonium fluoride and treated with an oxidant such as pyridinium dichromate or manganese dioxide to generate the corresponding compound of formula (I) where R 4 is f-butoxycarbonyl. Alternatively, intermediate compounds of formula (IX) may be prepared from the corresponding compounds of formula (VII) according to Scheme 1 A. SCHEME 1 A In step 6a of Scheme 1 A, a compound of formula (VII) is reacted sequentially with 1 ) (COCI)2 in a non polar solvent, e.g., toluene or methylene chloride, in the presence of a tertiary amine, e.g., triethyl amine or pyridine, then 2) with 2- mercaptopyridine N-oxide sodium salt (Na-MPNO) in BrCC to yield the corresponding compound of formula (XVI). In step 7a the compound of formula (XVI) is reacted with liquid ammonia at about 50°C in the presence of an ammonium salt of a weak acid, e.g., ammonium carbonate, in a pressure vessel to yield the corresponding compound of formula (IX). Alternatively, according to another general process (B), the compounds of formula (I) wherein X is (CR 10 R 11 ) P (CR 12 R 13 ) q / and both p and q are 1 , and R 0 , R 1 1 , R 2 and R 13 are hydrogen, may be prepared by the procedure shown in Step 5 of Scheme II wherein R 1 -6 are as defined for formula (I): -CH 2 CH 2 - SCHEME II In Step 1 of Scheme II, the enone function of compound (XI) is protected as a ketal with concomitant migration of the double bond to the 5, 6 position by refluxing with ethylene glycol in the presence of an acid, such as p- toluenesulfonic acid, in a solvent such as toluene which allows azeotropic removal of water to yield the corresponding compound of formula (XIII). ln Step 2, a compound of formula (XII) is treated with ozone in methanol alone or with one or more polar, protic or aprotic solvents mixtures, e.g., methylene chloride and methanol, at a temperature substantially below 0°C, e.g., from about -50 to about -80°C, followed by treatment at about -20°C with a reductant, such as zinc and acetic acid, then allowed to slowly warm to room temperature to yield the aldehyde of formula (XIII). In Step 3, a compound of formula (XIII) is reduced with a selective reducing agent, such as lithium tri-t-butoxyaluminumhydride in an aprotic solvent such as THF or diethyl ether to give the corresponding alcohol of formula (XIV). In Step 4, the alcohol functionality of a compound of formula (XIV) is converted to a leaving group, such as the corresponding methanesulfonate by treatment with methanesulfonyl chloride in an aprotic solvent such as methylene chloride in the presence of a hindered tertiary amine base such as triethylamine. Once transformed to a leaving group, the alcohol is displaced by treatment with a source of azide, such as sodium azide, in a polar, aprotic solvent, such as DMF, to give the corresponding alkyl azide of formula (XV). In Step 5, a compound of formula (XIV) is treated with a reductant such as triph- enylphosphine in THF at reflux followed by a strong protic acid such as 4M HCl to give the corresponding compound of formula (I) where X is -CH2CH2-. Alternatively, according to another general process (C), a compound of formula (I) may be converted into another compound of formula (I) using conventional procedures. Thus for example, a double bond may then be inserted between the carbon in the 1 position and the carbon in the 2 position by conventional means such as dehydrogenation with 2,3-dichloro-5,6-dicyano-1 ,4- benzoquinone by refluxing in an aprotic solvent such as dioxane to produce a compound of formula (I) which is unsaturated in the 1 , 2 position. A compound of formula (I) with a double bond in the 1 , 2 position may then be treated with the anion of trimethylsulfoxonium iodide, prepared by deprotonation with a base such as sodium hydride, in an aprotic, polar solvent such as DMSO to give a compound of formula (I) wherein R 1 and R 2 taken together form a cyclopropane ring. Optionally, a compound of formula (I) wherein R 3 is H and R 4 is acyl or acyloxy, such as t-butoxycarbonyl, may be treated with bromine at 0°C in an aprotic solvent such as methylene chloride to give the corresponding compound of formula (I) wherein R 3 is Br, which may then be treated with an organotin species such as phenyltrimethyltin in the presence of a palladium catalyst such as PdC.2(PPh3)2 and lithium chloride in a polar aprotic solvent such as dimethylformamide to give the corresponding compound of formula (I) wherein R 3 is methyl. Additionally, a compound of formula (I) wherein R 4 is acyl or acyloxy, such as t- butoxycarbonyl, may be treated with a strong hindered base such as lithium diisopropylamide at -78°C in an aprotic solvent such as THF followed by an electrophile, such as methyl iodide to give compounds of formula (I) wherein R 4 is methyl or lower alkyl. Also, a compound of formula (I) wherein R 3 is H may be treated with cuprous cyanide or -N,N-dimethylmethyleneammonium iodide in polar, aprotic solvents such as DMF or acetonitrile to give compounds of formula (I) wherein R 3 is -CN and -CH2N(CH3)2 respectively. Additionally, a compound of formula (I) wherein R 3 is H may be treated with a halogenated succinimide such as N-iodosuccinimide in a solvent such as THF to give a compound of formula (I) wherein R 3 is I. The compounds of formula (I) wherein R 4 is hydrogen may be reacted, via a nucleophilic reaction of the corresponding sodium or potassium salt, with L- lower alkyl, L-lower alkenyl, L-alkanoyl of 2 to 6 carbons, L-Alk 1 , L-lower cycloalkyl, L-lower cycloalkyl-lower alkyl, cycloalkyl, L-(Alk 1 ) n S(0) r R 7 , L-(Alk 1 ) n -phthalimidyl, L-(Alk 1 )-C0 2 H, L-(Alk 1 ) n -C0 R 7 , L-(Alk 1 ) n -Ar 1 , L-(Alk 1 ) n -CONR8R9. |_-(Alk 1 ) n -NR8R9 ) L-(Alk 1 ) n -OH or L-(Alk 1 ) n -OR 7 at a temperature of about 5 to about 100°C in a polar, aprotic solvent such as dimethylformamide, to yield the compounds of formula (I) wherein R 4 is other than hydrogen. The groups, R 7 -R 9 , Ar 1 and n, are as defined for formula (I) and L is a leaving group, such as defined in March, J., Advanced Organic Chemistry, 3d. Ed., 179, John Wiley & Sons, New York (1985) and in Hendrickson, J, et al., Organic Chemistry, 3d. Ed., 375-377, McGraw Hill, New York (1970), e.g., a halogen atom. Additionally, a compound of formula (I) wherein Z is CO2R 5 , and in particular wherein R 5 is CH3, may be treated with a strong base, such as lithium hydroxide in a solvent system such as THF or dioxane and water to give a compound of formula (I) where Z is CO2H. An acid of this formula may then be treated as described in Step 1 of Scheme 1 to yield the corresponding compounds of formula (I) wherein Z is COR 5 , CO2R 5 or CONR 1 R 1 5 . A particular step for the preparation of compounds of formula (I) wherein Z is - (Alk 2 ) n CONR 14 R 15 involves reacting a compound of formula (I) wherein Z is (Alk 2 ) n C02R 5 with an amine of formula HNR 14 R 15 , especially compounds wherein R 14 is hydrogen and R 15 is Ar 2 or lower cycloalkyl (optionally substituted independently with one or more R 7 or Ar 2 groups), e.g., a group of formula Ar 23 or a cycloalkyl group substituted with a group of formula Ar a . Intermediates of formula HNR 14 R 15 wherein R 14 is hydrogen and R 15 is Ar 2a or lower cycloalkyl substituted with a group of formula Ar 2a are novel compounds and represent a further aspect of the invention. Optionally, a compound of formula (I) wherein Z is CO2R 5 , and in particular wherein R 5 is CH3, may be reduced with a reducing agent such as diisobutyl¬ aluminum hydride and then reoxidized with Collins' reagent (Crθ3 « 2 pyridine) or another mild oxidant to produce a compound of formula (I) wherein Z is CHO, which may be treated with R 5 M (wherein M is a metal such as magnesium or lithium) and R 5 is Alk 1 -H (optionally substituted independently with one or more -CO2H CO2R 7 , Ar 2 or Ar 3 groups), lower cycloalkyl (optionally substituted independently with one or more -Alk 1 -H groups), adamantyl, Ar 2 , Ar 3 , -(lower cycloalkyl) n -Ar 2 or -(lower cycloalkyl) n -Ar 3 to give, after oxidation with pyridinium dichromate, a compound of formula (I) wherein Z is COR 5 . The above product of diisobutylaluminum hydride reduction may also be selectively oxidized at the 3-position by treatment with manganese (II) oxide to give a compound of formula (I) wherein the substitutent on C-17, that is, Z, is CH2-OH, i.e., a (Alk 2 )alkanol. This alcohol may then be converted to an amine by standard methods, e.g., conversion to a mesylate, displacement with a metal azide such as sodium azide, and reduction with hydrogen in the presence of a catalyst such as palladium on carbon. The alcohol or amine may then be reacted with acid chlorides, chloroformates, isocyanates or isothiocyanates to give compounds of formula (I) wherein Z is -(Alk 2 )-OCOR 5 , -(Alk )-OCθ2R 5 , -(Alk )-NR 5 'COR 5 , -(Alk 2 )-NR 5 '-C0 2 R 5 , -(Alk 2 )-NR 5 CONR 1 R 1 5 , -(Alk )-NR 5 CSNR 1 R 5 or -(Alk 2 )-OCO-NR R 1 5 . Further, these compounds of formula (I), wherein Z is -CHO, may be treated with a Wittig reagent, such as Et2θPOCH2COR 5 Et2θPOCH2Cθ2R 5 or Et2θPOCH2CONR 4 R 15 to give a compounds of formula (I) wherein Z is - CH=CH-COR 5 , CH=CH-Cθ2R 5 or CH=CH-CONR 14 R 1 5 respectively. It will be appreciated by those skilled in this art that for certain cases of R 3 and Z some Steps in the procedures shown in Scheme I and Scheme II are incompatible with survival of the functional groups of interest. In these cases, R 3 or Z is either introduced subsequent to the incompatible Step or is present in a protected form. An example of the former is the case where R 3 is halogen, in which case the halogen is introduced by reaction of a compound of formula (I) with a halogenated succinimide, such as N-bromosuccinimide. An example of the latter is the use of an ester or ether to protect a carboxylic acid or alcohol, respectively. Thus, according to another general pcocess (D), a compound of formula (I) according to the invention, or a salt thereof may be prepared by subjecting a protected derivative of formula (I) or a salt thereof to a reaction to remove the protecting group or groups. Thus, at an earlier stage in the preparation of a compound of formula (I) or a salt thereof it may have been necessary and/or desirable to protect one or more sensitive groups in the molecule to prevent undesirable side reactions. The protecting groups used in the preparation of compounds of formula (I) may be used in a conventional manner. See for example Protective Groups in Organic Chemistry, Ed. J.F.W. McOmie, Plenum Press, London (1973) or Protective Groups in Organic Synthesis, Theodora Green, John Wiley and Sons, New York (1981). Conventional amino protecting groups may include, for example, arylalkyi groups, such as benzyl, diphenylmethyl or triphenylmethyl groups; and acyl groups, such as N-benzyloxycarbonyl or t-butoxycarbonyl. Thus, compounds of formula (I) when R 4 represents hydrogen may be prepared by deprotection of a corresponding protected compound. Hydroxy groups may be protected, for example, by benzyl, diphenylmethyl or triphenylmethyl groups, acyl groups, such as acetyl, silicon protecting groups, such as triisopropysilyl or t-butyldimethylsilyl groups, or as tetrahydropyran derivatives. Removal of any protecting groups present may be achieved by conventional procedures. An arylalkyi group such as benzyl, may be cleaved by hydrogenolysis in the presence of a catalyst, e.g., palladium on charcoal; an acyl group such as N-benzyloxycarbonyl may be removed by hydrolysis with, for example, hydrogen bromide in acetic acid or by reduction, for example by catalytic hydrogenation; silicon protecting groups may be removed, for example, by treatment with fluoride ion or by hydrolysis under acidic conditions; tetrahydropyran groups may be cleaved by hydrolysis under acidic conditions. As will be appreciated, in any of the general processes (A) to (C) described above it may be desirable or even necessary to protect any sensitive groups in the molecule as just described. Thus, a reaction step involving deprotection of a protected derivative of general formula (I) or a salt thereof may be carried out subsequent to any of the above described processes (A) to (C). Thus, according to a further aspect of the invention, the following reactions may, if necessary and/or desired be carried out in any appropriate sequence subsequent to any of the processes (A) to (C): (i) removal of any protecting groups; and (ii) conversion of a compound of formula (I) or a salt thereof into a pharmaceutical acceptable salt or solvate thereof. Where it is desired to isolate a compound of the invention as a salt, for example as an acid addition salt, this may be achieved by treating the free base of formula (I) with an appropriate acid, particularly with an equivalent amount, or with creatinine sulfate in a polar, protic solvent, e.g., aqueous ethanol. As well as being employed as the last main step in the preparative sequence, the general methods indicated above for the preparation of the compounds of the invention may also be used for the introduction of the desired groups at an intermediate stage in the preparation of the required compound. It should therefore be appreciated that in such multi-stage processes, the sequence of reactions should be chosen in order that the reaction conditions do not affect groups present in the molecule which are desired in the final product. The compound of formula (I) and the intermediate compounds, (ll)-(XIV), shown in Schemes I and II may be purified by convenient methods of the art, e.g., chro- matography or crystallization. Steroid 5 -Reductases In Vitro Assay Enzyme activies may be determined using microsomes derived from: 1 ) prostate tissue from benign prostatic hyperplasia (BPH) patients; 2) recombinant baculovirus infected SF9 cells that express human type 1 5α-reductase; 3) prostate tissue from the rat; or 4) recombinant baculovirus infected SF9 cells that express human type 2 5α-reductase. Microsomes were prepared by homogenization of the tissue or cells, followed by differential centrifugation of the homogenate. Microsome extracts were incubated with varying concentrations of [1 ,2,6,7-3H]-testosterone, 1 mM NADPH, and varying amounts of the compounds of Formula I, i.e. a test compound, in buffer containing a NADPH regenerating system capable of maintaining NADPH concentrations for a period of time within the range 0.5-240 minutes. Corresponding incubations were carried out with no test compound as a control study. For type 1 IC50 measurements, assay components except testosterone were preincubated for 10 minutes at pH 7.0, and following the addition of 100nM testosterone the assays were allowed to proceed for 10-120 minutes. For type 2 IC50 measurements, assay components except testosterone were preincubated for 20 minutes at pH 6.0, and following the addition of 8nM testosterone the assays were allowed to proceed for 20-40 minutes. The percentage of conversion of testosterone to DHT in the presence of test compounds compared to the corresponding conversion in the control study was estimated using high pressure liquid chromatography (HPLC) with radiochemical detection. The results of these assays appear as ICso's reported in Table 1. TABLE 1 5-REDUCTASE in vitro INHIBITORY ACTIVITY In Vivo Evaluation of Steroid 5α-Reductase Inhibitors The in vivo activity of steroid 5α-reductase inhibitors may be determined in both acute and chronic rat models. The acute model utilizes castrated male rats that receive testosterone (1 mg) subcutaneously and test compound (10 mg/kg) p.o., at 0.5 hr. and 4.5 hr. prior to sacrifice, respectively. Levels of DHT in the serum and prostate indicate the ability of the test compound to inhibit steroid 5α- reductase in an acute rat model. Known steroid 5α-reductase inhibitors were tested in parallel to ensure consistency of the assay method. The chronic model also utilizes castrated male rats that are dosed daily with testosterone (20 μg/rat) subcutaneously and with test compound (0.01-10 mg/kg) p.o. or 7 days. The animals are then sacrificed and their prostates weighed. Reduction in the size of testosterone-stimulated prostate weight demonstrated activity of the test compound. Known steroid 5α-reductase inhibitors were tested in parallel to ensure consistency of the assay method. Utility The steroid 5α-reductase inhibitors of the present invention are useful in the treatment of androgen responsive diseases, e.g., benign and malignant diseases of the prostate, especially benign prostatic hyperplasia. For correlation of in vitro, rat in vivo and human clinical data relating to an inhibitor of 5α-reductase, see Stoner, J. Steroid Biochem. Molec. Biol., 37, 375 (1990); Brooks, et al., Steroids, 47, 1 (1986) and Rasmusson, J. Med. Chem., 29, 2298 (1986)). They are also useful in the treatment of prostatitis, prostate cancer, androgen mediated diseases of the skin, such as acne, hirsutism and male pattern baldness. Other hormone related diseases, e.g., polycystic ovary disease, would be expected to respond to treatment with these inhibitors. The amount of compound of formula (I) required to be effective as an 5α-re- ductase inhibitor will, of course, vary with the individual mammal being treated and is ultimately at the discretion of the medical or veterinary practitioner. The factors to be considered include the condition being treated, the route of administration, the nature of the formulation, the mammal's body weight, surface area, age and general condition, and the particular compound to be administered. However, a suitable effective 5α-reductase inhibitory dose is in the range of about 0.01 to about 5 mg/kg body weight per day, preferably in the range of about 0.05 to about 2 mg/kg per day. The total daily dose may be given as a single dose, multiple doses, e.g., two to six times per day, or by intravenous infusion for a selected duration. Dosages above or below the range cited above are within the scope of the present invention and may be administered to the individual patient if desired and necessary. For example, for a 75 kg mammal, a dose range would be about 5 to about 150 mg per day, and a typical dose would be about 20 mg per day. If discrete multiple doses are indicated, treatment might typically be 5 mg of a compound of formula (I) given 4 times per day. The compounds of formula (I) may also be administered in a topical formulation, e.g., ointment, cream, gel, or lotion, in cases of dermatological disorders such as acne vulgaris. An effective topical formulation contains from about 0.25% to about 10% by weight, of a compound of formula (I) which is applied at the rate of about 0.1 g to about 1.0 g per square centimeter of infected skin area. Typically a dose is about 1 gram of a 1 % ointment, cream, gel, or lotion of a compound of formula (I) gently rubbed onto the square centimeter of skin in need of treatment. Formulations Formulations of the present invention for medical use comprise an active compound, i.e., a compound of formula (I), together with an acceptable carrier thereof and optionally other therapeutically active ingredients. The carrier must be pharmaceutically acceptable in the sense of being compatible with the other ingredients of the formulation and not deleterious to the recipient thereof. The present invention, therefore, further provides a pharmaceutical formulation comprising a compound of formula (I) together with a pharmaceutically acceptable carrier thereof. The formulations include those suitable for oral, rectal, topical or parenteral (including subcutaneous, intramuscular and intravenous) administration. Preferred are those suitable for oral or parenteral administration. The formulations may conveniently be presented in unit dosage form and may be prepared by any of the methods well known in the art of pharmacy. All methods include the step of bringing the active compound into association with a carrier which constitutes one or more accessory ingredients. In general, the formulations are prepared by uniformly and intimately bringing the active compound into association with a liquid carrier or a finely divided solid carrier and then, if necessary, shaping the product into desired unit dosage form. Formulations of the present invention suitable for oral administration may be presented as discrete units such as capsules, cachets, tablets or lozenges, each containing a predetermined amount of the active compound; as a powder or granules; or a suspension or solution in an aqueous liquid or non-aqueous liquid, e.g., a syrup, an elixir, an emulsion or a draught. A tablet may be made by compression or molding, optionally with one or more accessory ingredients. Compressed tablets may be prepared by compressing in a suitable machine the active compound in a free-flowing form, e.g., a powder or granules, optionally mixed with accessory ingredients, e.g., binders, lubricants, inert diluents, surface active or dispersing agents. Molded tablets may be made by molding in a suitable machine, a mixture of the powdered active compound with any suitable carrier. A syrup or suspension may be made by adding the active compound to a concentrated, aqueous solution of a sugar, e.g., sucrose, to which may also be added any accessory ingredients. Such accessory ingredient(s) may include flavoring, an agent to retard crystallization of the sugar or an agent to increase -44- the solubility of any other ingredient, e.g., as a polyhydric alcohol, for example, glycero I or sorbitol. Formulations for rectal administration may be presented as a suppository with a conventional carrier, e.g., cocoa butter or Witepsol S55 (trademark of Dynamite Nobel Chemical, Germany), for a suppository base. Formulations suitable for parenteral administration conveniently comprise a sterile aqueous preparation of the active compound which is preferably isotonic with the blood of the recipient. Such formulations suitably comprise a solution or suspension of a pharmaceutically and pharmacologically acceptable acid addition salt of a compound of the formula (I) that is isotonic with the blood of the recipient. Thus, such formulations may conveniently contain distilled water, 5% dextrose in distilled water or saline and a pharmaceutically and pharmacologically acceptable acid addition salt of a compound of the formula (I) that has an appropriate, solubility in these solvents, for example the hydrochloride, isothionate and methanesulfonate salts, preferably the latter. Useful formulations also comprise concentrated solutions or solids containing the compound of formula (I) which upon dilution with an appropriate solvent give a solution suitable for parental administration above. Topical formulations include ointments, creams, gels and lotions which may be prepared by conventional methods known in the art of pharmacy. In addition to the ointment, cream, gel, or lotion base and the active ingredient, such topical formulation my also contain preservatives, perfumes, and additional active pharmaceutical agents. In addition to the aforementioned ingredients, the formulations of this invention may further include one or more optional accessory ingredient(s) utilized in the art of pharmaceutical formulations, e.g., diluents, buffers, flavoring agents, binders, surface active agents, thickeners, lubricants, suspending agents, preservatives (including antioxidants) and the like. EXAMPLES The following examples illustrate aspects of this invention but should not be ' 5 construed as limitations. The symbols and conventions used in these examples are consistent with those used in the contemporary chemical literature, for example, the Journal of the American Chemical Society. Exam le 1 10 17β-N-9-Fluorenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 1 ) A. 3β-Triisopropylsilyloxyetienic acid methyl ester A suspension of 3β-hydroxyetienic acid methyl ester (J. Med. Chem. 27, 1690) (516 g, 1.55 mol) in DMF (800 mL) is heated to 55°C, imidazole (264 g, 3.88 mol) added with vigorous mechanical stirring, followed by dropwise addition of 15 triisopropylsilylchlonde (360 g, 1.87 mol). The reaction becomes homogeneous after about half of the triisopropylsilylchlonde is added and the reaction temperature increases to ca. 70°C. The reaction is complete by TLC (35% ethyl acetate/hexanes) after 1.5 hrs and a thick slurry forms. The reaction is cooled to 0°C, 1 L of ice water added with stirring, the solid collected by filtration and 20 washed with water (500 mL) and methanol (500 mL). The resulting tan solid is suspended in methanol (1 L) and allowed to stir overnight to give, on filtration, 3β-triisopropylsilyloxyetienic acid methyl ester as a tan solid of sufficient purity to carry on to the following steps; yield: 667 g (88%); m. p. 116-118°C. Recrystallization from hexane gives an analytical sample as a white crystalline 25 solid: m.p. 124-125°C. Anal. Calcd. for C-3θH52θ3Si; C, 73.71 ; H, 10.72. Found: C, 73.79; H, 10.74. B. A solution of 3β-triisopropylsilyloxyetienic acid methyl ester (166 g, 0.34 mol), from part A, in methylene chloride (2 L) and methanol (800 mL) is cooled to - 30 78°C and treated with ozone until a blue color persists. At this stage, the peroxy compound of formula (V) may be isolated and recrystallized from hexanes to give an analytical sample; m. p. 119-121 °C. Anal. Calcd. for C31 H56O7S1; C, 65.45; H, 9.92. Found: C, 65.37; H, 9.86. However, more conveniently, the reaction is allowed to warm to -50°C under a stream of nitrogen, zinc dust 35 added (89 g, 1.36 mol), followed by glacial acetic acid (150 mL). The reaction is then allowed to warm to room temperature with stirring, filtered to remove zinc, the solution washed with water, saturated aqueous NaCl, saturated aqueous bicarbonate, dried over MgSθ4 and concentrated by rotary evaporation to give crude keto-aldehyde of formula (VI) as a white foam; yield: 176 g (99%). C. The compound prepared in part B above (176 g, 0.34 mol) is dissolved in acetone, cooled to 0°C and treated with Jones reagent (1.05 eq.) by dropwise addition over 15 min. After 10 min isopropanol is added, the reaction is allowed to stir for 10 min, is filtered, concentrated, dissolved in ethyl acetate (400 mL), washed with saturated NaCl, dried (MgSθ4) and concentrated to a green oil. The oil is dissolved in methylene chloride (150 mL), silica gel added (50 g), the mixture filtered through silica gel (200 g) and eluted with hexane/methylene chloride/ethyl acetate/ methanol (8:8:4:1 ) to give on concentration the corresponding keto-acid of formula (VII) as an off-white solid; yield: 163 g (89%). Recrystallization from ethyl acetate/hexanes gives a white crystalline solid; m. p. 143-145°C. Anal. Calcd. for C3θH52θ6Si; C, 67.12; H, 9.76. Found: C, 67.21 ; H, 9.80. D. 17β-Carbomethoxy-3β-triisopropylsilyloxy-6-azaandrost-5-ene A portion of the keto-acid of formula (VII) prepared above (110 g, 0.205 mol) is dissolved in methylene chloride (120 mL) and pyridine (44.7 mL) and is added dropwise to a solution of oxalyl chloride (48.3 mL, 0.553 mol) in methylene chloride (770 mL) at 0°C. After stirring 30 min, the reaction is poured into a mixture of saturated aqueous NaCl and ice (700 mL), the layers separated, the methylene chloride is washed with ice-cold 0.5M HCl (2X800 mL), ice-cold saturated NaHCθ3 (3X700 mL), dried (Na2S04) and concentrated to give the acid chloride as a white foam; yield: 110 g (96%). This material is then dissolved in acetone (1 L) and pentane (55 mL), cooled to 0°C, and treated with an aqueous solution of sodium azide (53 g, 0.82 mol, 164 mL). After 30 min the reaction is poured into a mixture of saturated NaCl (300 mL), saturated NaHCθ3 (300 mL) and ice (300 mL). Toluene is added (1 L), the layers separated, toluene layer washed with ice-cold saturated NaHCθ3 (3X400 mL), dried (Na2Sθ4), filtered and heated to 110°C to distill down to one-half the original volume. The solution is cooled to 38°C and treated with silica gel (212 g). The reaction is allowed to stir overnight, the silica removed by filtration and washed with 4:1 ethyl acetate/methanol (770 mL) to give 17β-carbomethoxy-3β- triisopropylsilyloxy-6-azaandrost-5-ene (a compound of formula ((IX)) as a white foam; yield: 106 g (94%). Flash chromatography on silica gel (30% ethyl acetate/hexanes) gives an analytical sample as a white foam. Anal. Calcd. for C29H5l N03Si; C, 71.11 ; H, 10.49; N, 2.86. Found: C, 71.04; H, 10.51 ; N, 2.80. E. 17β-Carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one A portion of the crude product from above, 17β-carbomethoxy-3β- triisopropylsilyloxy-6-azaandrost-5-ene (66 g, 0.135 mol) is dissolved in pyridine (500 mL), treated with di-f-butyldicarbonate (150 g, 0.69 mol) and allowed to stir overnight. The pyridine is removed by rotary evaporation and tetrabutylammonium fluoride (500 mL, 1 M, 0.5 mol) in tetrahydrofuran (THF) added carefully and the reaction heated to reflux for 5 min. The THF is removed by rotary evaporation, the residue dissolved in ethyl acetate (500 mL), washed cautiously with water, saturated aqueous NaCl, dried with MgSθ4 and concentrated. This material is dissolved in DMF (500 mL), is treated with pyridinium dichromate (153 g, 0.41 mol) and allowed to stir overnight. The reaction is poured into water (700 mL) and extracted with ethyl acetate (2X500 mL). The combined extracts are washed with water, 5% aqueous CuSθ4, saturated aqueous NaCl, dried over MgSθ4, concentrated and flash chromatographed (0-60%, diethyl ether/hexanes) to give 17β-carbomethoxy-6- f-butoxycarbonyl-6-azaandrost-4-en-3-one as an off-white foam; yield: 37.5 g (64%); FAB mass spec. MH+ 432. F. 17β-Carboxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one A solution of 17β-carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one (15.4 g, 36 mmol), from part E, in dioxane (150 mL) and water (100 mL) is treated with LiOH » H2θ (3.31 g, 79 mmol) and stirred overnight in a water bath. The reaction is poured into saturated aqueous NaHSθ4 (150 mL), extracted with methylene chloride (3X100 mL), extracts washed with saturated aqueous NaCl, dried over MgSθ4 and concentrated to a volume of 100 mL. At this point crystals begin to form and 2:1 hexanes/ethyl acetate (50 mL) is added, the mixture triturated, cooled to room temperature and 17β-carboxy-6-f- butoxycarbonyl-6-azaandrost-4-en-3-one collected as a fluffy white powder; yield: 9.44 g (63%); m. p. 215-216°C. Anal. Calcd. for C24H35NOs /4H2θ ; C, 68.30; H, 8.48; N, 3.32. Found: C, 68.45; H, 8.41 ; N, 3.28. The mother liquor is diluted with methylene chloride (100 mL), filtered through ' 5 silica gel, silica washed with 1 :1 diethyl ether/hexanes and the eluant concentrated to give recovered 17β-carbomethoxy-6-f-butoxycarbonyl-6- azaandrost-4-en-3-one; yield: 2.63 g (17%). The silica pad is then washed with 1 :9 methanol/methylene chloride (250 mL), the eluant concentrated, the resulting solid triturated with 2:1 hexanes/ethyl acetate (50 mL), cooled to 0°C 10 and 17β-carboxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one collected as a white powder; yield: 2.25 g (15%). The combined yield based on recovered starting material is 94%. G. 17β-N-9-Fluorenyl-carbamoyl-6-azaandrost-4-en-3-one 15 A sample of 17β-carboxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one (502 mg, 1.20 mmol), from part F, is suspended in toluene (15 mL), treated with pyridine (0.15 mL, 1.5 eq.), cooled to 0°C and thionyl chloride added (0.13 mL, 1.5 eq.). After 1 hr at 0°C the reaction is concentrated to a yellow solid, this crude acid chloride is dissolved in methylene chloride (15 mL) and added to a biphasic 20 mixture of methylene chloride (5 mL) and saturated aqueous NaHCθ3 (5 mL) which contains 9-fluorenyl amine hydrochloride (2.5 eq.). After stirring 45 min, ethyl acetate (50 mL) is added, the layers separated, the ethyl acetate layer washed with saturated aqueous NaHSθ4, saturated aqueous NaCl, dried over MgSθ4, concentrated and chromatographed -on silica gel (35-50% ethyl 25 acetate/hexanes) to give 17β-N-9-fluorenyl-carbamoyl-6-f-butoxycarbonyl-6- azaandrost-4-en-3-one as a yellow oil; yield: 558 mg (80%). This material is dissolved in methylene chloride (15 mL) and treated with trifluoroacetic acid (2 mL) at room temperature. After 3 hrs the reaction is concentrated, methylene chloride (50 mL) and saturated aqueous bicarbonate (50 mL) added, the layers 30 separated, methylene chloride washed with saturated aqueous NaCl, dried over MgSθ4, concentrated and crystallized from acetonitrile to give 17β-N-9- fluorenyl-carbamoyl-6-azaandrost-4-en-3-one as a white crystalline solid; yield: 325 mg (56%); m. p. 227-230°C. Anal. Calcd. for C32H36N2θ2 /2H2θ ; C, 78.49; H, 7.62; N, 5.72. Found: C, 78.25; H, 7.67; N, 5.65. 35 Example 2 17β-(1 -Qxo-2-cvclohexylethyl)-6-azaandrost-4-en-3-one (Compound 2) A solution of 17β-carboxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one (260 mg, 0.62 mmol), example 1 , part F, is dissolved in toluene (10 mL) and treated with pyridine (3 eq) and catalytic dimethylformamide, cooled to 0°C, and thionyl chloride added (80 mL, 1.10 mmol). The reaction is then allowed to warm to room temperature and stir for 1 hr. The solids are then removed by filtration, the solution concentrated, the resulting crude acid chloride dissolved in THF (6 mL), Cul added (120 mg, 0.62 mmol), cooled to -78°C and treated with methylenecyclo-hexylmagnesium bromide (2.0M in diethyl ether, 0.5 mL, 1 mmol). The reaction is allowed to warm to room temperature, stir for 30 min, is quenched with saturated NaHSθ4, extracted with ethyl acetate (2X25 mL), dried over MgSθ4, concentrated and chromatographed on silica gel (25% ethyl acetate/hexane) to give 17β-(1-oxo-2-(cyclohexylethyl))-6-t-butoxycarbonyl-6- azaan-drost-4-en-3-one; yield: 302 mg (98%). This material may be deprotected as described in example 1 , part G above to give, on crystallization from ether, 17β-(1-oxo-2-(cyclohexylethyl)-6-azaandrost-4-en-3-one; yield: 121 mg (50%); m. p. 214-216°C. Anal. Calcd. for C26H39Nθ2* 1 /2H2θ ; C, 76.80; H, 9.92; N, 3.44. Found: C, 76.61 ; H, 9.89; N, 3.49. Example 3 17β-Hydroxymethyl-(trimethylacetate)-6-azaandrost-4-en-3-one (Compound 3) A. 17β-Hydroxymethyl-3β-hydroxy-6-f-butoxycarbonyl-6-azaandrost-4-ene A solution of 17β-carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one (2.30 g, 5.33 mmol), example 1 , part E, in methylene chloride (70 mL) at -78°C is treated with diisobutylaluminum hydride (1.5M in toluene, 15 mL, 22.5 mmol). After 20 minutes the reaction is quenched with methanol (4 mL), methylene chloride added (150 mL), washed with 2N NaOH and water, dried over MgSθ4 and concentrated to give crude 17β-hydroxymethyl-3β-hydroxy-6-f- butoxycarbonyl-6-azaandrost-4-ene of sufficient purity to carry on to the following steps; yield: 2.16 g (99%). B. 17fS-Hydroxymethyl-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one A solution of 17β-Hydroxymethyl-3b-hydroxy-6-f-butoxycarbonyl-6-azaandrost- 4-ene (prepared as described in Example 5 above), in chloroform (250 mL) is treated with activated manganese(IV) oxide. After stirring 3.5 h, the manganese salts are removed by filtration through Celite. The solution is concentrated and chromatographed on silica gel (50% ethyl acetate/hexanes) to give 17β- hydroxymethyl-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one of sufficient purity to carry on to subsequent steps; yield 9.75 g (98%). C. 17β-Hydroxymethyl-(trimethylacetate)-6-azaandrost-4-en-3-one A solution of 17β-hydroxymethyl-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one (1.28 g, 3.17 mmol) in dichloromethane (32 mL) is cooled to 0°C and treated with triethylamine (0.67 mL, 4.8 mmol), 4-dimethylaminopyridine (58.4 mg, 0.48 mmol), and trimethylacetyl chloride (0.6 mL, 4.8 mmol). After stirring 1 h at 0°C and 3 h at room temperature, the reaction is diluted with dichloromethane, washed with saturated aqueous NaHSθ4, saturated aqueous NaHCθ3, and saturated aqueous NaCl, dried over MgSθ4, filtered, concentrated, and chromatographed on silica gel (25% ethyl acetate/hexanes) to give the crude ester. This material is treated with trifluoroacetic acid as described in Example 4 above to give, after recrystallization from dichloromethane/acetonitrile, 17β- Hydroxymethyl-(trimethylacetate)-6-azaandrost-4-en-3-one as a white powder; yield: 843 mg (69%); m.p. 239-241 °C. Anal. Calcd. for C24H37NO3: C, 74.38; H, 9.62; N, 3.61. Found: C, 74.17; H, 9.64; N, 3.58. Examples 4-86 Following the general procedure of example 1 , part G, wherein the hydrochloride salt of the amine is reacted with the acid chloride in the presence of sodium bicarbonate or by reaction with the free base or metal salt of the amine, for preparation of amides as the Z substituent in compounds of formula (I); the general procedure of example 2 for preparation of ketones as the Z substituent in compounds of formula (I); and the general procedure of example 3 for preparation of compounds where Z = CH2OCOR 5 and Z = CH2OCO2R 5 in compounds of formula (I) the following compounds were prepared: Example 4 17β-N-5-lndanylcarbamoyl-6-azaandrost-4-en-3-one (Compound 4) Melting Point: >270°C. Anal. Calcd. for C28H36N2θ2* 3 /4H2θ; c, 75.39; H, 8.47; N, 6.30. Found: C, 75.29; H, 8.42; N, 6.20. Example 5 17β-N-Phenyl-(4-morpholino)-carbamoyl-6-azaandrost-4-en-3-one (Compound a Melting Point: >250°C. Anal. Calcd. for C29H39N3θ3* 1 /4H2θ; C, 72.24; H, 8.26; N, 8.72. Found: C, 72.26; H, 8.26; N, 8.73. Example 6 17β-N-4-Benzodioxan-carbamoyl-6-azaandrost-4-en-3-onΘ (Compound 6) Melting Point: >260°C. Anal. Calcd. for C27H34N2O4; C, 71.97; H, 7.61 ; N, 6.22. Found: C, 71.70; H, 7.68; N, 6.18. Sample 7 17β-N-(3.4-Methylenedioxy phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 7) Melting Point: >264°C. Anal. Calcd. for C26H32N2θ4 « H2θ; C, 68.70; H, 7.54; N, 6.16. Found: C, 68.78; H, 7.60; N, 5.96. Example 8 17&-N-2-(3-lndolyl)ethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 8) Melting Point: 196-202°C. Anal. Calcd. for C29H37N3θ2* 1 /2H2θ; C, 74.33; H, 8.17; N, 8.97. Found: C, 74.31 ; H, 8.15; N, 8.87. Example 9 17β-N- ( 2-Trifluoromethvflphenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 9) Melting Point: 249-253°C. Anal. Calcd. for C26H3I N2θ2F3 »1 /3H2θ; C, 66.93; H, 6.84; N, 6.00. Found: C, 67.02; H, 7.00; N, 5.71. Example 10 17β-N-(2.5-Di-t-butvl)phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 10) Melting Point: 178-186°C. Anal. Calcd. for C-33H48N2θ2' 1 /4H2θ; C, 77.83; H, 9.60; N, 5.50. Found: C, 77.72; H, 9.61 ; N, 5.49. Example 11 17β-N-(4-Chlorophenvl )( phenvl)methvl-carbamovl-6-azaandrost-4-en-3-one (Compound 11) Melting Point: 245-250°C (decomp.). Anal. Calcd. for C32H37N2θ2CI «3 /8H2θ; C,7337;H,7-3S;N,535;CI,6.78. Found: C,7324;K723;N,538;αa76. Example 12 17β-N-.4-Methvhphenethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound m Melting Point: 244-246°C. Anal. Calcd. for C2δH38N2θ2' 1 /4H2θ; C, 76.59; H, 8.84; N, 6.38. Found: C, 76.97; H, 8.93; N, 6.40. Example 13 17β-N-( -Methyl)phenethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound Melting Point: 188-189°C. Anal. Calcd. for C-28H38N2θ2 «1 /4H2θ; C, 76.59; H, 8.84; N, 6.38. Found: C, 76.32; H, 9.00; N, 6.29. Example 14 17β-N-(2.6-Di- propvnphenvl-carbamovl-6-azaandrost-4-en-3-one (Compound i Melting Point: 198-200°C. Anal. Calcd. for C31 H44N2θ2' 1 /2H2θ; C, 76.66; H, 9.33; N, 5.76. Found: C, 76.77; H, 9.09; N, 5.77. Example 15 17fr-N-1 -Fluorenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 15) Melting Point: 215-230°C (decomp.). Anal. Calcd. for C32H36N2θ2' 3 /4H2θ; C, 77.78; H, 7.65; N, 5.67. Found: C, 77.91 ; H, 7.56; N, 5.76. Example 16 17β-N-(3.3-Diphenvl)propvl-carbamovl-6-azaandrost-4-en-3-one (Compound m Melting Point: 136-141 °C. Anal. Calcd. for C34H42N202 « 1/2H20; C, 78.57; H, 8.34; N, 5.39. Found: C, 78.86; H, 8.29; N, 5.40. Example 17 17β-N-,α-Phenvl)phenethvl-carbamovl-6-azaandrost-4-en-3-one (Compound I Melting Point: >250°C. Anal. Calcd. for C33H40N2O2; C, 79.80; H, 8.12; N, 5.64. Found: C, 79.74; H, 8.11 ; N, 5.60. Example 18 17β-N-(4-Fluorophenyl)(2-thiophene)methvl-carbamovl-6-azaandrost-4-en-3- one (Compound 18) Melting Point: 172-180°C. . Anal. Calcd. for C3θH35N2θ2S «3 /8H2θ; C,7Q16;H7fl2;N,5.46;S,625. Found: C,70.18;K6S9;N,550;S i 624. Example 19 17β-N-(2-Furanvnmethvl-carbamovl-6-azaandrost-4-en-3-one (Compound 19) Melting Point: 156-158°C. Anal. Calcd. for C24H32N2θ3 » 1 1 /4H2θ; C, 68.79; H, 8.30; N, 6.68. Found: C, 68.59; H, 8.18; N, 6.59. Example 20 17β-N-2-( 2-Pyridvl)ethvl-carbamovl-6-azaandrost-4-en-3-one (Compound 20) Melting Point: 132-135°C. Anal. Calcd. for C26H35N3θ2*H2θ; C, 71.04; H, 8.48; N, 9.55. Found: C, 70.99; H, 8.46; N, 9.12. Example 21 17β-N-(1.1 -Dimethyl)-2-hydroxyethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 21 ) Melting Point: 170°C (decomp.). FAB mass spec, for C23H36N2O3; 388.54 Found: 389 MH+ Sam le 22 17β-N-(2.2-Diphenvnethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 22) Melting Point: >250°C. FAB mass spec, for C33H40N2O2; 496.7 Found: 497 MH+ Example 23 17β-N-2-(Phenylthio ethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 23) Melting Point: 130-131 °C. Anal. Calcd. for C27H36N2O2SΗ2O; C, 68.90; H, 8.13; N, 5.95. Found: C, 68.59; H, 7.76; N, 5.94. Example 24 17β-N-Bis-(4-fluorophenyl methyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 24) Melting Point: 178-184°C. Anal. Calcd. for C32H36N2θ2F2' 1 /4H2θ; C, 73.47; H, 7.03; N, 5.36. Found: C, 73.55; H, 7.04; N, 5.33. Example 25 17B-N-.2.2-Diphenyl -hvdrazidyl-6-azaandrost-4-en-3-one .Compound 25) Melting Point: 194-196°C. Anal. Calcd. for C3i H37N3θ2 /2H2θ; C,7555;H,7.78;N,a53. Found: C, 75.44; H, 7.82; N, 8.50. Example 26 17β-(1 -Oxo-1 -(2.4-difluorophenyl)methyl)-6-azaandrost-4-en-3-one (Compound Melting Point: 238°C (decomp.). Anal. Calcd. for C25H29Nθ2F2 «1 /4H2θ; C,71 J 83;K7.11;N,335 Found: C, 72.07; H, 6.97; N, 3.64. Example 27 17β-Hvdroxymethyl-(3-methylbutyrate)-6-azaandrost-4-en-3-one (Compound m Melting Point: 137-138°C. Anal. Calcd. for C24H37NO3Η2O; C, 71.07; H, 9.69; N, 3.45. Found: C, 70.82; H, 9.69; N, 3.46. Example 28 17β-Hvdroxymethyl-(2.2-diphenylacetate)-6-azaandrost-4-en-3-one (Compound 22) Melting Point: 200-201 °C. Anal. Calcd. for C-33H39Nθ3* 1 /4H2θ; C, 78.93; H, 7.93; N, 2.79. Found: C, 79.14; H, 7.97; N, 2.79. Example 29 17B-N-2-(3-N-Methylpyrrole)ethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 29) Melting Point: 134-136°C. Anal. Calcd. for C26H37N3θ2' 1 /2H2θ; C, 72.19; H, 8.85; N, 9.71. Found: C, 71.88; H, 8.77; N, 9.60. Example 30 17β-N-(4-Trifluoromethylphenyl)methyl-carbamovl-6-azaandrost-4-en-3-one (Compound 30) Melting Point: 160-168°C. Anal. Calcd. for C27H33N2θ2F3 /4H2θ; C, 67.69; H, 7.05; N, 5.85. Found: C, 67.75; H, 7.09; N, 5.86. Example 31 17fr-N-methvlenecvclohexyl-carbamovl-6-azaandrost-4-en-3-one (Compound 3D Melting Point: 172-174°C. Anal. Calcd. for C26H4θN2θ2» 3 /4H2θ; C, 73.28; H, 9.82; N, 6.57. Found: C, 73.03; H, 9.88; N, 6.54. Example 32 17β-N-(1.1 -Dimethyl)-2-(4-fluorophenyl)ethyl-carbamovl-6-azaandrost-4-en-3- one (Compound 32) Melting Point: 144-148°C. Anal. Calcd. for C29H39N2O2F; C, 74.63; H, 8.43; N, 6.01. Found: C, 74.66; H, 8.48; N, 5.92. Example 33 17β-(1 -Oxo-1 (4-isopropoxyphenvnmethvl)-6-azaandrost-4-en-3-one (Compound 33) Melting Point: >260°C. Anal. Calcd. for C28H37Nθ3 «2 /3H2θ; C, 75.13; H, 8.63; N, 3.13. Found: C, 75.24; H, 8.57; N, 3.13. --_ -57- Examole 34 17β-N-(Dicvclohexyl)methyl-carbamoyl-6-azaandrost-4-en-3-one (Compound Melting Point: 245-246°C. Anal. Calcd. for C32H50N2O2; C, 77.68; H, 10.19; N, 5.66. Found: C, 77.54; H, 10.20; N, 5.60. Example 35 17β-N-(1 -Phenyl ethyl-carbamovl-6-azaandrost-4-en-3-one (Compound 35) Melting Point: 160-177°C. Anal. Calcd. for C27H36N2O2Η2O; C, 73.94; H, 8.73; K 6.39. Found: C, 73.95; H, 8,72; N, 6.37. Example 36 17β-N-(4-Decyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 36) Melting Point: 151-154°C. Anal. Calcd. for C35H52N2θ2 « H2θ; C, 76.32; H, 9.88; N, 5.09. Found: C, 75.99; H, 9.62; N, 5.06. Example 37 17β-N-(4-Benzvnpiperidyl-carbamovl-6-azaandrost-4-en-3-one (Compound 37) Melting Point: 250-251 °C. Anal. Calcd. for C31 H42N2θ2' 1 /4H2θ; C, 77.70; H, 8.94; N, 5.85. Found: C, 77.39; H, 8.88; N, 6.00. Example 38 17β-Hvdroxymethyl-(1-adamantylcarboxylate -6-azaandrost-4-en-3-one (Compound 38) Melting Point: >275°C. Anal. Calcd. for C30H43NO3; C, 77.38; H, 9.31 ; N, 3.01. Found: C, 77.05; H, 9.20; N, 3.07. Example 39 17β-N-Myrantyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 39 ) Melting Point: 182-185°C (foams). Anal. Calcd. for C29H44N2θ2* 3 4H2θ; C, 74.71 ; H, 9.84; N, 6.01. ' 5 Found: C, 74.69; H, 9.78; N, 6.00. Example 40 17β-N-(2.4.6-Trimethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 40) 0 Melting Point: 243-251 °C. Anal. Calcd. for C28H38N2θ2*2TFA; C, 58.00; H, 6.08; N, 4.23. Found: C, 59.62; H, 6.73; N, 4.73. Example 41 5 17β-N-Hydroxy-N-t-butyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 41 ) Melting Point: 252-254°C (decomp.). Anal. Calcd. for C23H36N2O3; C, 71.10; H, 9.34; N, 7.21. Found: C, 71.03; H, 9.39; N, 7.20. 0 Example 42 17β-N-(2.4-Difluoro)benzyl-carbamoyl-6-azaandrost-4-en-3-one (Compound . Melting Point: 134-137°C. Anal. Calcd. for C26H32N2θ2F2*H2θ; C, 67.80; H, 7.44; N, 6.08. 5 Found: C, 67.70; H, 7.25; N, 6.09. Example 43 17β-(1 -Qxo-3.3-diphenylpropyl -6-azaandrost-4-en-3-one (Compound 43) Melting Point: 106°C (shrinks). 0 FAB mass spec, for C33H39NO2; 481.68 Found: 482 MH+ Example 44 17β-N-(2-Chloro-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 44) Melting Point: 173-174°C. Anal. Calcd. for C26H30N2O2CIF3; C, 63.09; H, 6.11 ; N, 5.66. Found: C, 62.88; H, 6.48; N, 5.62. Example 45 17B-N-(2.2-Diphenyl-1-methvnethyl-carbamovl-6-azaandrost-4-en-3-one .Compound 45) Melting Point: >240°C. Anal. Calcd. for C34H42N2θ2 »1 /4H2θ; C, 79.26; H, 8.31 ; N, 5.44. Found: C, 79.17; H, 8.35; N, 5.46. Example 46 17β-N-(2.6-Dimethyl-4-bromo)phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 46) Melting Point: >256°C. Anal. Calcd. for C27H35N2θ2Br »1 /3H2θ; C, 64.15; H, 7.11 ; N, 5.54. Found: C, 64.30; H, 7.10; N, 5.53. Example 47 17β-N-Bis-(4-chlorophenvl)methvl-carbamovl-6-azaandrost-4-en-3-one (Compound 47) Melting Point: 188-194°C. Anal. Calcd. for C32H36N2θ2Cl2 «1 /4H2θ; C, 69.67; H, 6.58; N, 5.08. Found: C, 69.51 ; H, 6.56; N, 5.02. Example 48 17β-N-.2.6-Dimethyl-4-t-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 48) Melting Point: 203°C (shrinks). Anal. Calcd. for C31 H44N2θ2* 5 /4H2θ; C, 74.58; H, 9.39; N, 5.61. Found: C, 74.59; H, 9.30; N, 5.62. Example 49 17β-N-(2.6-Dibromo-4-isopropyl)ρhenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 49) Melting Point: 182°C (foams). Anal. Calcd. for C-28H36N2θ2Br2' 1 /3H2θ; C, 56.20; H, 6.18; N, 4.68. Found: C, 56.08; H, 6.24; N, 4.61. Example 50 17β-N-(2.5-Ditrifluoromethvl)phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 50) Melting Point: 144°C (shrinks). Anal. Calcd. for C27H3θN2θ2F6 »2 /3H2θ; C, 59.99; H, 5.84; N, 5.18. Found: C, 60.06; H, 6.10; N, 5.01. Example 51 17β-N-(4-t-Butyl)cvclohexyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 51) Melting Point: 229-231 °C. Anal. Calcd. for C29H46N2θ2 /4H2θ; C, 75.85; H, 10.21 ; N, 6.10. Found: C, 75.72; H, 10.22; N, 6.08. Example 52 17β-N-(2-Bromo)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 52) Melting Point: >280°C. Anal. Calcd. for C25H3I IM2θ2Br; C, 63.69; H, 6.63; N, 5.94. Found: C, 63.56; H, 6.67; N, 5.90. Example 53 17β-N-(2-Phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 53) Melting Point: >280°C. Anal. Calcd. for C31 H36N2θ2'2H2θ; C, 73.78; H, 7.99; N, 5.55. Found: C, 73.62; H, 7.17; N, 5.47. Example 54 17β-N-(2.6-Diethyl-3.5-dichloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 54) Melting Point: >250°C. Anal. Calcd. for C29H38N2O2CI2Η2O; C, 65.04; H, 7.53; N, 5.23. Found: C, 65.38; H, 7.49; N, 5.25. E am le 55 17β-N-(2.6-Diethyl-3-chloro)phenyl-carbamovl-6-azaandrost-4-en-3-one (Compound 55) Melting Point: 230-232°C. Anal. Calcd. for C-29H39N2θ2CI «1 /4H2θ; C, 71.44; H, 8.17; N, 5.75. Found: C, 71.41 ; H, 8.20; N, 5.75. Example 56 17β-N-(2- -Butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 56) Melting Point: 174-180°C. Anal. Calcd. for C29H4θN2θ2' 1 /2H2θ; C, 76.11 ; H, 9.03; N, 6.12. Found: C, 76.12; H, 9.02; N, 6.14. Example 57 17β-N-(3.5-Ditrifluoromethvnphenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 57) Melting Point: 194°C (shrinks). Anal. Calcd. for C27H3θN2θ2F6 «1 /3H2θ; C, 60.67; H, 5.78; N, 5.24. Found: C, 60.72; H, 5.82; N, 5.03. Example 58 17β-N-(2.4.6-Trichloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound S) Melting Point: >250°C. Anal. Calcd. for C25H29N2θ2Cl3* 1 /3H2θ; C, 60.55; H, 5.89; N, 5.65. Found: C, 60.52; H, 5.93; N, 5.65. Examole 59 17β-N-(3.5-Tetramethyl)cvclohexyl-carbamoyl-6-azaanrirost-4-en-3-one (Compound 59) Melting Point: 193-195°C. Anal. Calcd. for C29H46N2θ2Br2*H2θ; C, 73.68; H, 10.24; N, 5.93. Found: C, 73.72; H, 10.34; N, 5.99. Example 60 17β-(1 -Oxo-1 -((2.4.6-tri-røropvl)phenvl)methvl)-6-azaandrost-4-en-3-one (Compound 60) Melting Point: >230°C. Anal. Calcd. for C34H49Nθ2' 1 /2H2θ; C, 79.64; H, 9.82; N, 2.73. Found: C, 79.53; H, 9.57; N, 2.73. Example 61 17β-N-(2-Bromo-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 61 ) Melting Point: 170-190°C (decomp.). Anal. Calcd. for C26H3θN2θ2BrF3; C, 57.89; H, 5.61 ; N, 5.19. Found: C, 57.83; H, 5.63; N, 5.15. Example 62 17β-N-(2-t-Butyl-6-methyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 62) Melting Point: 190-220°C (decomp.). FAB mass spec, for C30H42N2O2; 462.68 Found: 463 MH+ Example 63 17β-N-(1 -Methyl-1 -phenyl)ethyl-carbamovl-6-azaandrost-4-en-3-onR (Compound 63) Melting Point: 156°C (shrinks). Anal. Calcd. for C28H38N2θ2' 1 /2H2θ; C, 75.81 ; H, 8.86; N, 6.31. Found: C, 75.90; H, 8.84; N, 6.30. Example 64 17B-N-1 -(4-Chlorophenyl)cvclopentyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 64) Melting Point: 186-189°C. Anal. Calcd. for C30H39N2O2CI; C, 72.77; H, 7.94; N, 5.66. Found: C, 72.54; H, 7.92; N, 5.63. Example 65 17β-N-(1-(4-Chlorophenyl)-2-methyl)propvl-carbamovl-6-azaandrost-4-en-3- one (Compound 65) Melting Point: 177-179°C. Anal. Calcd. for C29H3gN2θ2CI »1 /4H2θ; C, 71.43; H, 8.17; N, 5.75. Found: C, 71.43; H, 8.20; N, 5.79. Example 66 17β-N-(1.1 -Di-4-chlorophenyl)ethyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 66) Melting Point: 186-194°C. Anal. Calcd. for C33H38N2O2CI2; C, 70.00; H, 6.78; N, 4.96; Cl, 12.54. Found: C, 69.89; H, 6.84; N, 4.92; Cl, 12.41. Example 67 17fr-N-(1 -Phenyl-1 -(4-t-butyl phenyl)methyl-carbamoyl-6-azaandrost-4-en-3- one (Compound 67) Melting Point: 188-192°C. Anal. Calcd. for C36H46N2θ2' 1 /4H2θ; C, 79.59; H, 8.63; N, 5.16. Found: C, 79.52; H, 8.67; N, 5.10. Example 68 17β-(1 -Qxo-1 -(2-norbomyl)methyl)-6-azaandrost-4-en-3-one (Compound 68) Melting Point: 128°C (shrinks). High res. mass spec, for C26H37NO2; 396.2903 Found: 396.2911 MH+ Example 69 17β-N-(2.6-Dibromo-4-chloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 69) Melting Point: 240-244°C (decomp.). Anal. Calcd. for C25H29N2θ2Br2CI «1 /2H2θ; C, 50.57; H, 5.09; N, 4.72. Found: C, 50.41 ; H, 4.94; N, 4.62. Example 70 17β-N-(2.6-Diethyl-4-bromo)phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 70 ) Melting Point: 212-216°C. Anal. Calcd. for C29H3gN2θ2Br; C, 66.01 ; H, 7.46; N, 5.31 ; Br, 15.16. Found: C, 65.94; H, 7.46; N, 5.29; Br, 15.24. Example 71 17fi-N-(2-Bromo-4-t-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 71) Melting Point: >250°C. Anal. Calcd. for C29H39N2θ2Br; C, 66.01 ; H, 7.46; N, 5.31 ; Br, 15.16. Found: C, 65.91 ; H, 7.42; N, 5.31 ; Br, 15.09. Example 72 17β-N-(2-Chloro-4-f-butyl)phenyl-carbamov.-6-azaandrost-4-en-3-one (Compound 72) Melting Point: 235-246°C (decomp.). Anal. Calcd. for C29H39N2O2CI; C, 71.44; H, 8.16; N, 5.74; Cl, 7.27. Found: C, 71.52; H, 8.19; N, 5.75; Cl, 7.26. Example 73 17β-N-(1 -t-Butyl-1 -(4-t-butylphenyl))methyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 73) Melting Point: 198-204°C. Anal. Calcd. for C34H5θN2θ2Br2; C, 76.72; H, 9.75; N, 5.26. Found: C, 76.81 ; H, 9.65; N, 5.26. Example 74 17β-N-(5-Bromo-2-^butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 74) Melting Point: 192-195°C. Anal. Calcd. for C29H39N2θ2Br » H2θ; C, 63.85; H, 7.58; N, 5.14. Found: C, 63.75; H, 7.58; N, 5.16. Example 75 17β-N-(5-Chloro-2-t-butyl)phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 75) Melting Point: 235-246°C (decomp.). Anal. Calcd. for C29H39N2O2OH2O; C, 69.51 ; H, 8.25; N, 5.59. Found: C, 69.34; H, 8.22; N, 5.98. Example 76 17β-N-(2.6-Diethyl)phenyl-carbamovl-6-azaandrost-4-en-3-one (Compound 76) Melting Point: 190-196°C. Anal. Calcd. for C29H4θN2θ2' 3 /δH2θ; C, 76.49; H, 9.02; N, 6.15. Found: C, 76.59; H, 9.01 ; N, 6.10. Example 77 17β-N-(4-Bromo-2-f-butyl)phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 77) Melting Point: 162°C (foams). Anal. Calcd. for C29H39N2θ2Br; C, 66.01 ; H, 7.46; N, 5.31. Found: C, 65.94; H, 7.60; N, 5.20. Example 78 17β-N-(2- -Butyl-5-cvano)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 78) Melting Point: >300°C. Anal. Calcd. for C3θH39N3θ2* 3 /4H2θ; C, 73.96; H, 8.38; N, 8.63. Found: C, 74.11 ; H, 8.48; N, 8.68. Example 79 17β-N-(2-(0-4-Tolyl)-5-trifluoromethyl)Dhenyl-carbamoyl-6-azaandrost-4-en-3- one (Compound 79) Melting Point: 134-142°C. Anal. Calcd. for C33H37N2θ3F3« 1 /3 -propanol; C,6935;H,653;N,494. Found: C, 69.61 ; H, 6.86; N, 4.73. Example 80 17β-N-(2-(0-2-Methoxyphenyl)-5-trifluoromethvl))phenvl-carbamovl-6- azaandrost-4-en-3-one (Compound 80) Melting Point: 132-142°C. FAB mass spec, for C33H37N2O4F3; 582.67 Found: 583 MH+ Example 81 17β-N-(2-(0-4-Chlorophenyl)-5-trifluoromethvnphenvl-carbamovl-6-azaandmst- 4-en-3-one (Compound 81) Melting Point: 132-142°C. Anal. Calcd. for C32H34N2θ3CIF3« 1 /3 -propanol «1 /3H2θ; C, 64.65; H, 6.14; N, 4.57. Found: C,64.74;H,623;N,45a Example 82 17β-N-(2-Nitro-4-t-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 82) Melting Point: >265°C. Anal. Calcd. for C29H39N3O4; C, 70.56; H, 7.96; N, 8.51. Found: C, 70.42; H, 7.98; N, 8.42. Example 83 17β-N-(2-(0-Phenyl)-5-(1.1 -dimethyl)propyl)phenyl-carbamoyl-6-azaandrost-4- en-3-one (Compound 83) Melting Point: 147-152°C. Anal. Calcd. for C36H46N2θ3* 1 /2H2θ; C, 76.70; H, 8.40; N, 4.97. Found: C, 76.55; H, 8.39; N, 4.95. Example 84 17β-N-(2-Ethyl-4-cvano)phenvl-carbamovl-6-azaandrost-4-en-3-one .Compound 84) Melting Point: >250°C. Anal. Calcd. for C28H35N3O2; C, 75.47; H, 7.92; N, 9.43. Found: C, 75.26; H, 7.95; N, 9.35. Example 85 17β-N-(2-Ethylsulfonyl-5-trifluoromethvl)phenvl-carbamovl-6-azaandrost-4-en- 3-one (Compound 85) Melting Point: >250°C. Anal. Calcd. for C-28H35N2O4F3SΗ2O; C, 58.93; H, 6.54; N, 4.91. Found: C, 58.87; H, 6.54; N, 4.89. Example 86 17β-N-(3.5-Di-t-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound fifi) Melting Point: 212-216°C. Anal. Calcd. for C33H48N2O2; C, 77.49; H, 9.61 ; N, 5.48. Found: C, 77.59; H, 9.57; N, 5.53. Example 67 17β-N-(2-t-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 87) A. 4-Trifluoromethyl-α,α-dimethylbenzyl alcohol To magnesium turnings (30.2 g, 1.24 mol) in THF (30 mL) is added 1 ,2- dibromoethane (0.7 mL) followed by dropwise addition, over 1 h, of 4- bromotrifluoromethylbenzene (200 g, 0.89 mol) dissolved in THF (700 mL). The reaction is heated occasionally to maintain a gentle reflux and is stirred 45 min after the addition is complete. The dark reaction mixture is then cooled in an ice bath and acetone (103 g, 1.78 mol) added dropwise. After stirring an additional 1.5 h the reaction is carefully quenched with aqueous saturated NaHSθ4, ethyl acetate added, the organics dried over MgSθ4, concentrated and purified by silica gel chromatography (9:1 to 3:2, hexane to ethyl acetate) to give 4- trifluoromethyl-α,α-dimethylbenzyl alcohol of sufficient purity to carry to the next step; yield: 114 g (63%). B. 4-Trifluoromethyl-α,α-dimethylbenzyl chloride The alcohol from step A above (54 g, 0.27 mol) is treated with ethereal HCl (1.3 L, 1 M) followed by anhydrous zinc chloride (53 mL, 1 M in ether) and the reaction allowed to stir for 22 h at room temperature. The reaction is then washed with water, aqueous 2 N NaOH, dried over MgSθ4, concentrated and purified by silica gel chromatography (8:1 hexane to ethyl acetate) to give 4- trifluoromethyl-α,α-dimethylbenzyl chloride of sufficient purity to carry to the next step; yield: 50.5 g (85%). C. 4-Trifluoromethyl-f-butylbenzene To a toluene solution of dimethylzinc (150 mL, 2.0 M, 0.30 mol) at -78°C is added a CH2CI2 solution of titanium tetrachloride (150 mL, 1.0 M, 0.15 mol) and after stirring for 30 min 4-trifluoromethyl-α,α-dimethylbenzyl chloride (83.3 g, 0.373 mol) in CH2CI2 (100 mL) is added dropwise over 20 min. After the addition is complete the reaction is allowed to warm to -40°C over 1.5 h. After an additional 2 h at -40°C the brown reaction mixture is carefully poured onto crushed ice, extracted with CH2CI2 (2X500 mL), the combined extracts dried over MgSθ4 and concentrated to give 4-trifluoromethyl- -butylbenzene; yield: 60.3 g (80%). Anal. Calcd. for C11 H13F3: C, 65.32; H, 6.48. Found: C, 65.11 ; H, 6.38. D. 2-?-Butyl-5-trifluoromethyinitrobenzene To a solution of 4-trifluoromethyl-f-butylbenzene (25.6 g, 126 mmol) in H2SO4 (143 mL) at 0°C is added a mixture of HNO3 (90%, 42 mL) and H2SO4 (87 mL). After 30 min the ice bath is removed and the reaction stirred for 2.5 h further. gg- . The yellow mixture is then poured onto crushed ice and extracted with ethyl acetate, the ethyl acetate washed with 2N NaOH and water, dried (MgS04) and concentrated to a dark oil. Purification by silica gel chromatography (14:1 hexane to ethyl acetate) gives 2-f-butyl-5-trifluoromethylnitrobenzene of sufficient purity to carry to the next step; yield: 18.0 g (58%). E. 2-f-Butyl-5-trifluoromethylaniline A solution of 2-f-butyl-5-trifluoromethylnitrobenzene (26.0 g, 105 mmol) in ethanol (95%, 100 mL) is treated with 10% Pd/C (2 g) and placed under a hydrogen atmosphere (40 psi) on a Parr apparatus for 1.5 h. The mixture is filtered, concentrated and purified by silica gel chromatography (7:1 hexane to ethyl acetate) to give 2-f-butyl-5-trifluoromethylaniline as an oil; yield: 20.2 g (89%). Anal. Calcd. for C11 H14F3N: C, 60.80; H, 6.50; N, 6.45. Found: C, 60.89; H, 6.50; N, 6.51. F. 17β-N-(2-f-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one The aniline prepared above is reacted with the acid chloride of 17β-carboxy-6-f- butoxycarbonyl-6-azaandrost-4-en-3-one (prepared as in example 1 , part G) and deprotected as in example 1 , part G to give: 7β-N-(2-t-butyl-5- trifluoro)phenyl-carbamoyl-6-azaandrost-4-en-3-one. Melting Point: 186-190°C. Anal. Calcd. for C30H39N2O2F3: C.69.73; H.7.61 ; N.5.42. Found: C, 69.45; H, 7.66; N, 5.38. Examples 88-92 Following the general procedure of example 1 , part G, wherein the hydrochloride salt of the amine is reacted with the acid chloride in the presence of sodium bicarbonate or by reaction with the free base or metal salt of the amine, for preparation of amides as the Z substituent in compounds of formula (I); the general procedure of example 2 for preparation of ketones as the Z substituent in compounds of formula (I); and the general procedure of example 3 for preparation of compounds where Z = CH2OCOR 5 and Z = CH2OCO2R 5 in compounds of formula (I) the following compounds were prepared: Example 88 17β-N-(2-f-Butyl-5-phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 88) Melting Point: 207-209°C. Anal. Calcd. for C35H44N2θ2* 1 /4H2θ; C, 79.43; H, 8.48; N, 5.29. Found: C, 79.53; H, 8.54; N, 5.31. Example 89 17β-Hvdroxymethyl-(menthvlcarbonate -6-azaandrost-4-en-3-one (Compound S2) Melting Point: 152-155°C. Anal. Calcd. for C30H47NO4Η2O; C, 71.53; H, 9.81 ; N, 2.78. Found: C, 71.63; H, 9.79; N, 2.80. Example 90 17β-Hvdroxvmethyl-(Dhenvlcarbonate)-6-azaandrost-4-en-3-one (Compound 90) Melting Point: 247-249°C (decomp.). Anal. Calcd. for C26H33N04 «1 /8CH2Cl2; C, 72.27; H, 7.72; N, 3.23. Found: C, 71.82; H, 7.77; N, 3.25. Example 91 17β-N-(2-f-Butyl-5-(N-methyl)methylsulfonamide)phenyl-6-azaandrost-4-en-3- ono (Compound 91) Melting Point: 290-292°C (decomp.). Anal. Calcd. for C31 H45N3O4S; C, 65.40; H, 8.23; N, 7.38. Found: C, 65.41 ; H, 8.23; N, 7.42. Example 92 17β-N-(3-Nitro-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 92) Melting Point: 214-217°C. Anal. Calcd. for C29H39N3O4; C, 69.30; H, 8.02; N, 8.36. Found: C, 69.11 ; H, 8.09; N, 8.12. Examplg 93 17B-N- ( 2.6-Di- -propyl)phenyl-carbamoyl-6-azaandrost-1 .4-dien-3-one (Compound 93) A. 17β-Carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-1 ,4-dien-3-one A solution of 17β-carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one (2.00 g, 4.63 mmol), prepared in example 1 , part E, in dioxane (50 mL) is treated with 2,3-dichloro-5,6-dicyano-1 ,4-benzoquinone (DDQ, 1.37 g, 6.02 mmol) and p-nitrophenol (10 mg). The reaction is heated to reflux for 2 hrs, poured into ice water (150 mL), extracted with ethyl acetate (3X100 mL), extracts washed with saturated aqueous NaHSθ3, 2N NaOH, saturated aqueous NaCl, dried over MgSθ4, concentrated and chromatographed on silica gel (40% ethyl acetate/hexanes) to give crude 17β-carbomethoxy-6- - butoxycarbonyl-6-azaandrost-1 ,4-dien-3-one as a tan solid of sufficient purity to carry on to the following steps; yield: 1.53 g (76%). B. 17 -N-(2,6-Di- propyl)phenyl-carbamoyl-6-f-butoxycarbonyl-6-azaandrost- 1 ,4-dien-3-one A sample of crude 17β-carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-1 ,4- dien-3-one (0.90 g, 2.20 mmol), prepared in part A, is demethylated as in example ' 1 , part F and then coupled via the acid chloride (described in example 1 , part G) with the lithium anion of 2,6-di-Apropylaniline to give after chromatography (30-50% ethyl acetate/hexanes), 17β-N-(2,6-di-A propyl)phenyl-carbamoyl-6-f-butoxycarbonyl-6-azaandrost-1 ,4-dien-3-one as a white foam; yield: 0.210 g (16%). C. 17β-N-(2,6-Di-Apropyl)phenyl-carbamoyl-6-azaandrost-1 ,4-dien-3-one A sample of 17β-N-(2,6-di-Apropyl)phenyl-carbamoyl-6-f-butoxycarbonyl-6- azaandrost-1 ,4-dien-3-one (188 mg, 0.320 mmol), prepared in part B above, is treated with trifluoroacetic acid as described in example 1 , part G above to give, after chromatography (50% ethyl acetate/hexanes to 5% methanol/chloroform), 17β-N-(2,6-di-Apropyl)phenyl-carbamoyl-6-azaandrost-1 ,4-dien-3-one as a white solid; yield: 98 mg (62%); m. p. 273-276°C. Anal. Calcd. for C31 H42N2O2Η2O ; C, 75.73; H, 8.81 ; N, 5.69. Found: C, 75.84; H, 8.95; N, 5.68. Example 94 17&-N-(2.6-Di-Apropyl)phenyl-carbamoyl-6-azaandrost-4-methyl-1.4-dien-3-one (Compound 94) A. 17β-Carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-4-methyl-1 ,4-dien-3- one A solution of 17β-carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-1 ,4-dien-3- one (2.57 g, 5.98 mmol), prepared in example 93, part A in methylene chloride (60 mL) containing anhydrous K2CO3 (8.03 g, 58 mmol) at 0°C is treated with bromine (6.1 mmol) dissolved in methylene chloride (12 mL). After 30 min the mixture is filtered, washed with 10% aqueous NaHSθ3, dried over Na2Sθ4 and concentrated to a foam. This material is dissolved in dimethylformamide (20 mL), treated with phenyltrimethyltin (2.0 mL, 11.4 mmol) and lithium chloride (180 mg, 4.3 mmol), heated to 130°C and treated with PdCl2(PPh3)2 (400 mg, 0.57 mmol). After 1.5 hr the reaction is allowed to cool to room temperature, filtered through Celite, poured into water, the water extracted with ethyl acetate (3X30 mL), extracts washed with water (3X100 mL) and 1% aqueous ammonia (2X100 mL), dried over Na2S04, concentrated and chromatographed (5-10% ethyl acetate/methylene chloride) to give 17β-carbomethoxy-6-f- butoxycarbonyl-6-azaandrost-4-methyl-1 ,4-dien-3-one; yield: 1.25 g (47%). B. 17β-N-(2,6-Di-Apropyl)phenyl-carbamoyl-6-azaandrost-4-methyl-1 ,4-dien-3- one A sample of crude 17β-carbomethoxy-6-f-butoxycarbonyl-6-azaandrost-4- methyl-1 ,4-dien-3-one (0.45 g, 1.01 mmol), prepared in part A, is hydrolized as in example 1 , part F and then coupled with 2,6-di-Apropylaniline as described in example 93, part B, deprotected as in example 1 , part G, to give after chromatography (2.5-10% methanol/methylene chloride), 17β-N-(2,6-di-A propyl)phenyl-carbamoyl-6-azaandrost-4-methyl-1 ,4-dien-3-one as a white powder; yield: 70 mg (14%); m. p. 181-184°C. Anal. Calcd. for C32H44N2θ 2 ' V4H2O ; C, 77.93; H, 9.09; N, 5.67. Found: C, 77.81 ; H, 9.12; N, 5.58. Example 95 17β-(N-APropyl-N-(N-Apropylcarbamoyl))-carbamoyl-6-azaandrost-4-en-3-one (Compound 95) A solution of 17β-carboxy-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one (500 mg, 1.2 mmol), example 1 , part F, is dissolved in methylene chloride (70 mL), treated with diisopropyl carbodiimide (0.21 mL, 1.3 mmol) and stirred at room temperature for 20 hrs. The reaction mixture is then concentrated, the solid dissolved in ethyl acetate (70 mL), the ethyl acetate washed with saturated aqueous NaHCθ3 (2X70 mL), 1 N HCl (3X70 mL), saturated aqueous NaCl (70 mL), dried over Na2Sθ4, and concentrated to a yellow foam. Chromatography on silica gel (50% ethyl acetate/hexanes) gives 17β-(N-Apropyl-N-(N-A propylcarbamoyl))-carbamoyl-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one as a white foam; yield: 600 mg (65%). FAB mass spec, for C31 H49N3O5; 543.75 Found: 544 MH+ This material is deprotected with TFA as in example 1 , part G to give, after crystallization from acetonitrile, 17β-(N- -propyl-N-(N-A propylcarbamoyl))-carbamoyl-6-azaandrost-4-en-3-one as a white solid; yield: 220 mg (64%); m. p. 162°C (decomp.). Anal. Calcd. for C26H4l N3θ3 « H2θ ; C, 67.64; H, 9.39 N, 9.10. Found: C, 67.58; H, 9.42; N, 9.09. Example 96 17β-(N-cvclohexyl-N-(N-cvclohexylcarbamoyl) -carbamoyl-6-azaandrost-4-en- 3-pne (Compound 96) Prepared as described in example 95. Melting Point: 186-187°C. Anal. Calcd. for C32H49N3θ3 /4H2θ; C, 72.76; H, 9.44; N, 7.95. Found: C, 72.74; H, 9.45; N, 7.68. Example 97 17β-Aminomethyl-(acetamide)-6-azaandmst-4-en-3-one (Compound 97) A. 17β-Azidomethyl-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one A solution of 17β-hydroxymethyl-6-f-butoxycarbonyl-6-azaandrost-4-en-3- one (2.03 g, 5.04 mmol) prepared in example 3, part 15, in dichloromethane (50 mL) is treated with triethylamine (0.88 mL, 6.3 mmol), DMAP (0.155 g, 1.27 mmol) and methanesulfonyl chloride (0.43 mL, 5.6 mmol). After 3 hrs, the reaction is diluted with dichloromethane (50 mL), washed with 1 N HCl, saturated aqueous NaCl and dried over MgSθ4. Concentration gives a white foam which is dissolved in dimethylformamide (50 mL), treated with sodium azide (0.94 g, 14.5 mmol) and heated to 75°C for 16 hrs. The reaction is poured into ethyl acetate, washed with water (5X100 mL), dried over MgSθ4, concentrated and chromatographed on silica gel (20% ethyl acetate/hexane) to give 17β-azidomethyl-6-f-butoxycarbonyl-6-azaandrost-4-en-3-one as a white foam of sufficient purity to carry on to the next step. B. 17β-Aminomethyl-(acetamide)-6-azaandrost-4-en-3-one A sample of the azide from step A above (20 mg, 50 mmol) is dissolved in 1 :1 ethanol/tetrahydrofuran (2 mL), treated with 10% Pd(C) (3.2 mg) and placed under a hydrogen atmosphere for 10 min. The reaction is filtered, concentrated, dissolved in dichloromethane (2 mL) and treated with pyridine (0.1 mL) and acetic anhydride (0.06 mL). After 64 hrs the reaction is diluted with dichloromethane, dried over Na2Sθ4, concentrated and chromatographed on silica gel (ethyl acetate) to give 17β-aminomethyl-(acetamide)-6-f- butoxycarbonyl-6-azaandrost-4-en-3-one which is deprotected with TFA as in example 1 , part G to give 17β-aminomethyl-(acetamide)-6-azaandrost-4-en-3- one as a white solid; yield: 3 mg (17%). FAB mass spec, for C21 H32N2O2; 344.5. Found: 345 MH+. Example 98 17β-Aminomethyl-(1 -adamantylurea)-6-azaandrost-4-en-3-one (Compound 98) A sample of the azide from example 97, part A (100 mg, 230 mmol) is dissolved in 1 :2 ethanol/tetrahydrofuran (6 mL), treated with 10% Pd(C) (60 mg) and placed under a hydrogen atmosphere for 1 hr. The reaction is filtered, concentrated, dissolved in tetrahydrofuran and treated with 1- adamantylisocyanate at room temperature for 6 days. The reaction is concentrated and chromatographed on silica gel (40-70% ethyl acetate/hexanes) to give 17β-aminomethyl-(1-adamantylurea)-6-f- butoxycarbonyl-6-azaandrost-4-en-3-one which is deprotected with TFA as in example 1 , part G to give 17β-aminomethyl-(1-adamantylurea)-6-azaandrost-4- en-3-one as a white solid; yield: 47 mg (35%); m. p. 227-229°C (foams.). Anal. Calcd. for C3θH45N3θ2*H2θ ; C, 72.40; H, 9.52; N, 8.44. Found: C, 72.37; H, 9.42; N, 8.46. Examples 99-148 Following the general procedure of example 1 , part G, wherein the hydrochloride salt of the amine is reacted with the acid chloride in the presence of sodium bicarbonate or by reaction with the free base or metal salt of the amine, for preparation of amides as the Z substituent in compounds of formula (I); the general procedure of example 3 for preparation of compounds where Z = CH2θCONR 14 R 15 in compounds of formula (I); the general procedure of example 8 and 11 in WO 93/13124 for preparation of compounds of formula (I), where R 3 = Cl and Me respectively, the following compounds were prepared. Novel amines used to prepare compounds of formula (I) where the Z substituent is an amide were prepared as described in example 87 above or by the method of Stille, J.K. Pure Appl. Chem., 57, 1771 (1985). When either R 14 or R 15 is an aryl substituted cycloalkyl residue the amine may be prepared by Curtius rearrangement of the corresponding acid, where available, or by the method of He, X. er a/., J. Med. Chem., 36, 1188 (1993), i.e. by reacting the corresponding cycloalkanone with the appropriate aryl Grignard reagent followed by conversion of the resulting alcohol to the amine by treatment with sodium azide and trifluoroacetic acid followed by reduction of the azide with lithium aluminum hydride. Aryl substituted cyclopropylamines are prepared by radium catalyzed insertion of the appropriate aryl-α-diazo-ester (prepared by the method of Baum, J.S. et al., Synthetic Comm., 17, 1709 (1987)) into the appropriate olefin (as described by Davies, H.W. et al., Tetrahedron Lett., 30, 5057 (1989)) followed by saponifi cation of the ester and Curtius rearrangement of the acid to give the desired amine. Example 99 17β-Hvdroxymethyl-(2.6-diisopropylphenylcarbamate)-6-azaandrost-4-en-3-one (Compound 99) Melting Point: 161 -163°C. Anal. Calcd. for C32H46N2O3Η2O; C, 73.25; H, 9.22; N, 5.34. Found: C, 73.08; H, 9.19; N, 5.29. Example 100 17β-N-(4-f-Butyl-2-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 100) Melting Point: 186-190°C. Anal. Calcd. for C30H39N2O2F3 /4H2O; C, 69.14; H, 7.64; N, 5.38. Found: C, 69.12; H, 7.65; N, 5.35. Example 1Q1 17β-N-1-(2.4-Dichlorophenyl)cvclopropyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 101 ) Melting Point: 160-180°C (decomp.). Anal. Calcd. for C28H34N2θ2Cl2 «1 /2H2θ; C, 65.86; H, 6.91 ; N, 5.49. Found: C, 69.64; H, 6.89; N, 5.47. Example 102 17β-N-1-(3-Trifluoromethylphenyl)cvclopentvl-carbamovl-6-azaandrost-4-en-3- one (Compound 102) Melting Point: 156-159°C. Anal. Calcd. for C31 H3gN2θ2F3*H2θ; C, 68.11 ; H, 7.56; N, 5.12. Found: C, 67.79; H, 7.48; N, 5.02. Example 1 Q3 17β-N-(1 -Ethyl-1 -pheπyl)propyl-carbamovl-6-azaandrost-4-en-3-one (Compound 103) Melting Point: 157-160°C. Anal. Calcd. for C3θH42N2θ2 »3 /4H2θ; C, 75.67; H, 9.20; N, 5.88. Found: C, 75.80; H, 9.09; N, 5.78. Example 104 17β-N-1-(4-Fluorophenyl)cvclopentvl-carhamovl-6-azaandrost-4-en-3-one (Compound 104) Melting Point: 220-223°C. Anal. Calcd. for C3θH39N2θ2F «1 / 2 H2θ; C, 73.71 ; H, 8.17; N, 5.75. Found: C, 73.89; H, 8.27; N, 5.74. 1 -Amino-1 -(4-fluorophenyl)cyclopentane: 13 C NMR (CDCI3) δ 162.8, 159.6, 145.2, 127.0, 126.8, 114.8, 114.5, 63.5, 41.5, 23.4. Example 105 17B-N-(2-t-Butyl-5-N.N-diethylcarbamoyl)phenyl-carbamoyl-6-azaandrost-4-en- 3-one ( Compound 105) Melting Point: 167-169°C. Anal. Calcd. for C34H49N3θ3 «1 /2H2θ; C, 73.34; H, 9.05; N, 7.55. Found: C, 73.41 ; H, 9.10; N, 7.42. Example 106 17β-N-1-(4-Trifluoromethylphenyl)cvclopentvl-carbamovl-6-azaandrost-4-en-3- one (Compound 106) Melting Point: 201 -203°C. Anal. Calcd. for C31 H39N2θ2F3 « 2 H2θ; C, 69.51 ; H, 7.55; N, 5.09. Found: C, 69.25; H, 7.50; N, 5.21. 1-Amino-1-(4-trifluoromethylphenyl)cyclopentane: 13 C NMR (CDCI3) δ 153.6, 153.5, 128.5, 128.1 , 126.0, 125.7, 125.1 , 125.1 , 125.0, 125.0, 122.4, 63.8, 41.7, 23.5 . Example 107 17β-N-(3-Cvano)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 107) Melting Point: 202-208°C. Anal. Calcd. for C26H3I N3O2Η2O; C, 71.70; H, 7.64; N, 9.65. Found: C, 71.88; H, 7.69; N, 9.48. Example 108 17β-N-(4-f-Butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 108) Melting Point: 304-307°C. Anal. Calcd. for C29H4θN2θ2* 1 4H2θ; C, 76.86; H, 9.00; N, 6.18. Found: C, 76.83; H, 8.92; N, 6.54. Example 109 17β-N-1-(4-Fluorophenyl)cvclohexyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 109) Melting Point: 167-169°C. Anal. Calcd. for C31 H41 N2O2F /3H2O; C, 74.66; H, 8.42; N, 5.61. Found: C, 74.72; H, 8.43; N, 5.53. Example 110 17β-N-1 -(2.2-Dimethvl)indanvl-carbamovl-6-azaandrost-4-en-3-one (Compound llϋ Melting Point: 178-182°C. Anal. Calcd. for C30H40N2O2; C, 75.99; H, 8.82; N, 5.91. Found: C, 75.64; H, 8.84; N, 5.88. Example 111 17β-N-1 -(4-Methoxyphenyl)cvclohexyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 111 ) Melting Point: 167-169°C. Anal. Calcd. for C32H44N2θ3 «3 / 4 H2θ; C, 74.17; H, 8.85; N, 5.41. Found: C, 73.95; H, 8.92; N, 5.38. Example 112 17β-N-(2-Phenvl-5-trifluoromethyl)phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 112) Melting Point: 304-306°C. Anal. Calcd. for C32H35N2θ2F3;C, 71.62; H, 6.57; N, 5.22. Found: C, 71.56; H, 6.56; N, 5.27. Example 113 17β-N-.2-Methoxy-5-chloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 113) Melting Point: 237-238°C. Anal. Calcd. for C26H33N2θ3CI' 3 / H2θ; C, 66.37; H, 7.39; N, 5.95. Found: C, 66.17; H, 7.31 ; N, 5.96. Example 114 17β-N-(2-Carboethoxy)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 114) Melting Point: 282-286°C. Anal. Calcd. for C28H36N2O4; C, 72.39; H, 7.81 ; N, 6.03. Found: C, 72.15; H, 7.88; N, 6.10. Example 115 17β-N-1-(4-Methoxyphenyl)cvclopentyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 115) Melting Point: 160°C. Anal. Calcd. for C31 H42N2O3Η2O; C, 73.19; H, 8.72; N, 5.51. Found: C, 73.26; H, 8.67; N, 5.46. Example 116 17β-N-(2.5-bis(Trifluoromethyl))phenyl-carbamoyl-6-azaandrost-4-methyl-4-en- 3-one (Compound 116) Melting Point: 142-146°C. Anal. Calcd. for C28H32N2θ2F6;C, 61.96; H, 5.95; N, 5.16. Found: C, 61.70; H, 5.99; N, 5.07. Example 117 17β^-N-(2-t-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-methvl-4- en-3-one (Compound 117) Melting Point: 188°C. Anal. Calcd. for C3l H4l N2θ2F3' 3 /4H2θ; C, 68.42; H, 7.87; N, 5.15. Found: C, 68.31 ; H, 7.71 ; N, 5.08. Example 118 17β-N-(2.5-Di- -butyl)phenyl-carbamovl-6-azaandrost-4-methvl-4-en-3-one (Compound 118) Melting Point: 168-176°C. Anal. Calcd. for C34H5θN2θ2* 1 / 2 H2θ; C, 77.37; H, 9.74; N, 5.31. Found: C, 77.32; H, 9.74; N, 5.28. Example 119 17β-N-(2.5-Diethoxy)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound ±m Melting Point: 277-279°C. Anal. Calcd. for C29H4θN2θ4' 1 /4H2θ; C, 71.80; H, 8.41 ; N, 5.77. Found: C, 71.50; H, 8.45; N, 5.74. Example 120 17β-N-(2-f-Butyl-5-(4-chloroρhenyl )phenvl-carbamovl-6-azaandrost-4-en-3-one (Compound 120) Melting Point: 214-216°C. Anal. Calcd. for C35H43N2O2CM 1 /2H2θ; C, 71.71 ; H, 7.91 ; N, 4.78. Found: C, 71.46; H, 7.88; N, 4.81. Example 121 17β-N-1-(4-t-Butylphenyl)cvclopentyl-carbamovl-6-azaandrost-4-en-3-one (Compound 121) Melting Point: 222-232°C. Anal. Calcd. for C34H48N2θ2* 3 /4H2θ; C, 77.01 ; H, 9.41 ; N, 5.28. Found: C, 77.05; H, 9.46; N, 5.25. 1-Amino-1-(4-f-butylphenyl)cyclopentane: 13 C NMR (CDCI3) δ 148.9, 146.4, 125.1 , 125.0, 124.9, 63.7, 41.2, 34.3, 31.4, 31.3, 23.6. Example 122 17β-N-1 -(4-f-Butylphenyl)cvclohexyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 122) Melting Point: 203°C. Anal. Calcd. for C35H50N2O2; C, 76.60; H, 9.55; N, 5.10. Found: C, 76.43; H, 9.59; N, 5.05. 1-Amino-1-(4-/-butylphenyl)cyclohexane: 13 C NMR (CDCI3) δ 148.8, 146.8, 125.0, 124.6, 53.4, 39.2, 34.2, 31.2, 25.7, 22.4. Example 123 17B-N-(2-Benzoyl phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 123) Melting Point: 290-294°C. Anal. Calcd. for C32H36N2θ3' 1 / 2 H2θ; C, 76.01 ; H, 7.38; N, 5.54. Found: C, 76.19; H, 7.35; N, 5.47. Example 124 17β-N-1-(3.4-Methylenedioxyphenyl)cvclohexyl-carbamoyl-6-azaandrost-4-en- 3-one (Compound 124) Melting Point: 192°C. Anal. Calcd. for C32H42N2θ4 «3 /4H2θ; C, 72.22; H, 8.24; N, 5.26. Found: C, 72.01 ; H, 8.25; N, 5.14. 1-Amino-1-(3,4-methylenedioxyphenyl)cyclohexane: 13 C NMR (CDCI3) δ 147.5, 145.6, 144.1 , 117.9, 107.6, 106.1 , 100.7, 53.6, 39.5, 25.6, 22.4. Example 125 17β-N-1-(4-Chlorophenyl)cvclopentyl-carbamoyl-6-azaandrost-4-methyl-4-en-3- one (Compound 125) Melting Point: 166°C. High res. mass spec, for C31 H41 N2O2CI; 509.2935. Found: 509.2941. Example 126 17β-N-(2.5-bisπ " rifluoromethyl) phenyl-carbamoyl-6-azaandrost-4-chloro-4-en- 3-one (Compound 126) Melting Point: 148-154°C. Anal. Calcd. for C27H29N2O2CIF6; C, 57.48; H, 5.19; N, 4.98. Found: C, 57.43; H, 5.21 ; N, 4.91. Example 127 17B-N-(2-t-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-chloro-4- en-3-one (Compound 127) Melting Point: 174-178°C. Anal. Calcd. for C30H38N2O2CIF3; C, 65.37; H, 6.95; N, 5.08. Found: C, 65.49; H, 7.01 ; N, 5.05. Example 128 17&-N-(2-Methoxy-5-f-butvnphenyl-carbamovl-6-azaandrost-4-en-3-one (Compound 128) Melting Point: 170-175°C. Anal. Calcd. for C30H42N2O3Η2O; C, 72.55; H, 8.93; N, 5.64. Found: C, 72.50; H, 8.94; N, 5.69. Example 129 17B-N-(2-Fluoro-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 129) Melting Point: 167-170°C. Anal. Calcd. for C26H3θN2θ2F4 «3 /4H2θ; C, 63.47; H, 6.45; N, 5.69. Found: C, 63.46; H, 6.26; N, 5.76. Example 130 17β-N-(1-(4-Biphenyl)-2.2-diethyl)cvclopropvl-carbamovl-6-azaandrost-4-en-3- one (Compound 130) Melting Point: 178-182°C. Anal. Calcd. for C38H48N2O2; C, 79.54; H, 8.61 ; N, 4.88. Found: C, 79.68; H, 8.55; N, 4.86. 1-Amino-1 -(1 -(4-biphenyl)-2,2-diethyl)cyclopropane: 13 C NMR (CDCI3) δ 144.6, 140.9, 139.1 , 128.8, 128.7, 127.1 , 127.0, 127.0, 46.9, 33.2, 25.6, 24.1 , 22.3, 11.6, 10.5. Example 131 17β-N-(1 -(4-Trifluoromethylphenyl)-2.2-diethyl)cvclopropyl-carbamoyl-6- azaandrost-4-en-3-one (Compound 131 ) Melting Point: 176-182°C. Anal. Calcd. for C33H43N2θ2F3' 3 H2θ; C, 70.44; H, 7.82; N, 4.98. Found: C, 70.44; H, 7.83; N, 4.97. 1 -Amino-1 -(1 -(4-trifluoromethylphenyl)-2,2-diethyl)cyclopropane: 13 C NMR (CDCI 3 ) δ 149.5, 149.5, 129.7, 128.8, 128.4, 126.1 , 126.0, 125.5, 125.5, 125.4, 125.3, 122.5, 46.9, 33.4, 25.6, 24.3, 22.2, 11.5, 10.4. Example 132 17β-N-3-(2-Carbomethoxy-5-f-butyl)thiophenyl-carbamoyl-6-azaandrost-4-en-3- one (Compound 132) Melting Point: 273-275°C. Anal. Calcd. for C29H40N2O4S; C, 67.94; H, 7.86; N, 5.46. Found: C, 67.67; H, 7.90; N, 5.42. Example 133 17β-N-(2-Phenylsulfonyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 133) Melting Point: 175-180°C. Anal. Calcd. for C31 H36N2θ4S «1 / 4 H2θ; C, 69.31 ; H, 6.84; N, 5.22. Found: C, 69.18; H, 7.01 ; N, 5.15. Example 134 17β-N-(4-Carboethoxy)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 134 Melting Point: 299-301 °C. Anal. Calcd. for C28H36N2θ4 «1 /4H2θ; C, 71.69; H, 7.84; N, 5.97. Found: C, 71.74; H, 7.83; N, 5.98. Example 135 17β-N-(2-(4-t-Butyl)phenyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4- en-3-one (Compound 135) Melting Point: 185-189°C. Anal. Calcd. for C36H43N2O2F3; c . 72 - 95 ; H - 7 - 3 J N - 4 - 73 - Found: C, 72.84; H, 7.36; N, 4.65. Example 136 17β-N-1-(4-f-Butylphenyl)cvcloheptyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 136) Melting Point: 190-194°C. Anal. Calcd. for C36H52N2θ2* 3 /4H2θ; C, 77.27; H, 9.65; N, 5.00. Found: C, 77.44; H, 9.66; N, 5.01. 1 -Amino-1 -(4-f-butylphenyl)cycloheptane: 13 C NMR (CDCI3) δ 148.7, 148.2, 125.0, 124.7, 57.3, 42.9, 34.2, 31.2, 29.7, 23.1. Example 137 17β-N-(3-Carboxy)phenyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 13Z Melting Point: 258-260°C. Anal. Calcd. for C26H32N2θ4*HCM 1 /4H2θ; C, 63.02; H, 7.22; N, 5.65. Found: C, 63.02; H, 7.22; N, 5.62. Example 138 17β-N-1 -( 9-Fluorenonvn-carbamoyl-6-azaandrost-4-en-3-one (Compound 138) Melting Point: 260-264°C. Anal. Calcd. for C32H34N2θ3*1 V4H2O; C, 74.32; H, 7.11 ; N, 5.42. Found: C, 74.49; H, 7.12; N, 5.38. Example 139 17β-N-1-(4-(-Butylphenyl)cvclohexyl-carbamoyl-6-azaandrost-4-chloro-4-en-3- one (Compound 139) Melting Point: 158°C. FAB mass spec, for C35H49N2O2CI; 565.2. Found: 565.2 M + . Example 140 17β-N-(2.6-Diethyl-4-(4-chlorophenvn)phenyl-carbamovl-6-azaandrost-4-en-3- one (Compound 140) Melting Point: >300°C. Anal. Calcd. for C35H43N2θ2CI »1 / 4 H2θ; C, 74.58; H, 7.78; N, 4.97. Found: C, 74.27; H, 7.80; N, 4.97. Example 141 17β-N-(2-Phenyl)-hvdrazidyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 141) Melting Point: 193-195°C. Anal. Calcd. for C25H33N3O2Η2O; C, 70.56; H, 8.29; N, 9.87. Found: C, 70.17; H, 8.26; N, 9.87. Example 142 17β-N-(2- Butylcarbamoyl-5-trifluoromethyl)phenyl-carbamovl-6-azaandrost-4- en-3-one (Compound 142) Melting Point: 198-200°C. Anal. Calcd. for C31 H40N3O3F3; C, 66.53; H, 7.20; N, 7.51. Found: C, 66.41 ; H, 7.32; N, 7.36. Example 143 17β-N-4-(4-t-Butylphenyl)tetrahvdrothiopvranvl-carbamovl-6-azaandrost-4-en-3- one (Compound 143) Melting Point: 197°C. Anal. Calcd. for C34H48N2θ2S« 3 / H2θ; C, 72.62; H, 8.87; N, 4.98. Found: C, 72.46; H, 8.97; N, 4.99. 4-Amino-4-(4- -butylphenyl)tetrahydrothiopyran: 13 C NMR (CDCI3) δ 149.3, 146.7, 125.3, 124.3, 52.6, 39.8, 34.2, 31.3, 24.3. Example 144 17β-N-9-(4-t-Butylphenyl)bicvclo[3.3.11nonyl-carbamoyl-6-azaandrost-4-en-3- one (Compound 144) Melting Point: >260°C. Anal. Calcd. for C38H54N2θ2*1 V4H2O. C, 76.92; H, 9.60; N, 4.72. Found: C, 76.82; H, 9.63; N, 4.67. 9-Amino-9-(4-f-Butylphenyl)bicyclo[3.3.1]nonane: 13 C NMR (CDCI3) δ 148.6, 144.8, 125.4, 125.3, 124.7, 124.3, 64.1 , 55.4, 38.9, 35.3, 34.2, 31.7, 31.3, 31.3, 29.1 , 27.0, 24.4, 21.1 , 20.5. Example 145 17β-N-4-(4-t-Butylphenyl)tetrahydropyranyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 145) Melting Point: 181 °C. Anal. Calcd. for C34H48N2θ3 «3 /4H2θ; C, 74.75; H, 9.13; N, 5.13. Found: C, 74.72; H, 9.11 ; N, 5.15. 4-Amino-4-(4-f-butylphenyl)tetrahydropyran: 13 C NMR (CDCI3) δ 149.4, 146.5, 125.3, 124.3, 64.1 , 51.2, 38.9, 31.3, 22.4. Example 146 17β-N-1 -(4-Chlorophenyl)cvclohexyl-carbamoyl-6-azaandrost-4-en-3-one (Compound 146) Melting Point: 184°C. Anal. Calcd. for C31 H41 N2O2CI; C, 73.13; H, 8.11 ; N, 5.50. Found: C, 72.74; H, 8.39; N, 5.38. Example 147 17B-N-(2-t-Butyl-5-(4-f-butyl)phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3- one ( Compound 147) Melting Point: >300 Anal. Calcd. for C39H52N2O2; C.78.22; H.9.09; N.4.68. Found: C.77.98; H.8.99; N.4.65 Example 148 17β-N-1-(4-Chlorophenyl)cvclopentyl-carbamovl-6-azaandrost-4-chloro-4-en-3- one (Compound 148) FAB mass -spec, for C30H38N2O2CI2 529.55 Found: 529.3M+ Example 149 Pharmaceutical formulations (A) Transdermal System - For 1000 Patches The silicon fluid and active compound are mixed together and the colloidal silicon dioxide is added to increase viscosity. The material is then dosed into a subsequently heat sealed polymeric laminate comprised of the following: polyester release liner, skin contact adhesive composed of silicone or acrylic polymers, a control membrane which is a polyolefin (e.g. polyethylene, polyvinyl acetate or polyurethane), and an impermeable backing membrane made of a polyester multilaminate. The resulting laminated sheet is then cut into 10 sq. cm patches. (B) Oral Tablet - For 1000 Tablets Ingredients mount Active compound 20 g Starch 20 g Magnesium Stearate Λ g The active compound and the starch are granulated with water and dried. Magnesium stearate is added to the dried granules and the mixture is thoroughly blended. The blended mixture is compressed into tablets. (C) Suppository - For 1000 Suppositories Amount Active compound 25 g Theobromine sodium salicylate 250 g Witepsol S55 1725 g The inactive ingredients are mixed and melted. The active compound is then distributed in the molten mixture, poured into molds and allowed to cool. The active compound and buffering agents are dissolved in the propylene glycol at about 50°C. The water for injection is then added with stirring and the resulting solution is filtered, filled into ampules, sealed and sterilized by autoclaving. (E) Capsule - For 1000 Capsules Ingredients Amount Active Compound 20 g Lactose 450 g Magnesium stearate 5 9 The finely ground active compound is mixed with the lactose and stearate and packed into gelatin capsules.

Claims: Claims: 1. A compound of formula (I): wherein R 1 and R 2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R 1 and R 2 is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is hydrogen, -Alk 1 -H (optionally substituted with one or more halogens), lower cycloalkyl, lower cycloalkyl-lower alkyl), halogen, -(Alk 1 ) n -Cθ2H, -(Alk 1 ) n -C0 2 R 7 , -(Alk 1 ) n -Ar 1 , -(Alk 1 ) n -CONRδR9, -(Alk ) n -NR8R9, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -CN, -(Alk 1 )-OH, -(Alk 1 ) n -COR 7 ; or -(Alk 1 ) n -OR 7 ; wherein Alk 1 is lower alkylene, lower alkenylene or lower alkynylene, n is 0 or 1 , r is 0, 1 or 2, R 7 is -Alk -H, -(Alk 1 ) n -Ar 1 or lower cycloalkyl, R8 and R are independently hydrogen, -Alk 1 -H or lower cycloalkyl, Ar 1 is a homocyclic aryl group of 6 to 14 carbons; R 4 is hydrogen, -Alk 1 -H, lower cycloalkyl, lower cycloalkyl-lower alkyl, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -phthalimidyl, -(Alk 1 )-C0 2 H, -(Alk 1 ) n -C0 2 R 7 , -(Alk 1 ) n -COR 7 > -(Alk 1 ) n -Ar 1 , AIk 1 ) n -CONR8R9, -(Alk ) n -NR8R9, -(Alk 1 ) n -OH or -(Alk ) n -OR 7 ; X is, (CR 1 ° R 11 (CR 12 R 13 ) q wherein R 1 0, R 1 1 , R 12 and R 1 3 are independently hydrogen or lower alkyl, p and q are independently either 0 or 1 ; and, i) Yis hydrogen or hydroxyand Zis -(Alk ) n -COR 5 , -(Alk ) n -C0 2 R 5 , -(Alk ) n -COSR 5 , -(Alk 2 ) n -CONR 1 R 15 ,-(Alk )-OCθ2R 5 ,-(Alk 2 )-OCOR 5 , -(Alk 2 )-OCONR R 15 , -(Alk )-OR 5 , -(Alk )-NR 5 'COR 5 , -(Alk )-NR 5 'C0 2 R 5 , -(Alk )-NR 5 CONR 1 R 15 , -(Alk 2 ) n -CONR 5 NR 14 R 15 , -(Alk 2 ) n -CONR 5 CONR R 15 , -(Alk 2 )- NR 5 CSNR 14 R 1 5 or -(Alk 2 ) n -CONR 5 CSNR 4 R 15 ; wherein Alk 2 is (C -. 2) alkylene, (C2-12) alkenylene or (C2- 2) alkynylene, R 5 and R 5 ' are independently hydrogen, -Alk 1 -H (optionally substituted independently with one or more CO2H, CO2R 7 , Ar 2 , Ar 3 or cyano groups), (Alk 1 ) n -(lower cycloalkyl (optionally substituted independently with one or more -Alk 1 -H groups)), adamantyl, norbornyl, Ar 2 , Ar 3 , (lower cycloalkyl)-Ar 2 or (lower cycloalkyl)-Ar 3 ; wherein Ar 2 is a homocyclic aromatic group of 6 to 14 carbon ring atoms (optionally substituted independently with one or more -Alk 2 -H (optionally substituted independently with one or more halogens), -(Alk 1 ) n COR 7 > -(Alk 1 ) n -OH, -(Alk 1 ) n -OR 6 , -(Alk ) n -Ar 3 , -(Alk ) n -C0 2 H, -(Alk 1 ) n -C0 2 R 7 , S(0) r R 7 , NR 8 S(0) r R 16 , NR8R9, CONR8R9, lower cycloalkyl, lower alkoxy, -(Alk 1 ) n -Ar 1 (optionally substituted with one or more -Alk 1 -H or halogen), methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogens); wherein R1 6 is -Alk 1 -H (optionally substituted independently with one or more halogens), lower cycloalkyl (optionally substituted independently with one or more halogens, or -Alk 1 -H (optionally substituted independently with one or more halogens)) or -(Alk 1 ) n -Ar 1 (wherein Ar 1 is optionally substituted independently with one or more lower alkoxy, cyano, halogen or -Alk 1 -H (optionally substituted independently with one or more halogens); Ar 3 is an aromatic group of 5 to 14 ring atoms, at least one of which is O, N or S (optionally substituted independently with one or more -Alk 1 -H (optionally substituted independently with one or more halogens), lower cycloalkyl, lower alkoxy, CO2H, CO2R 7 , -(Alk 1 ) n -Ar 1 , cyano or halogen); R 1 and R 5 are a) independently, hydroxy, hydrogen, -Alk -H, lower alkoxy, -(Alk 1 ) n -adamantyl, -(Alk 1 ) n -myrantyl, -(Alk 1 ) n -norbomyl, -(Alk 1 ) n -fluorenyl, -(Alk 1 ) n -fluorenonyl, -(Alk 1 ) n -indanyl (optionally substituted with one or more -Alk 1 -H), -Alk 1 -H (optionally substituted independently with one or more halogens, cyano, cycloalkyl, SR 5 , COR 5 , CONR 5 R 7 , NR 5 'COR 5 , NR 5 'C0 2 R 5 , NR 5 'CONHR 5 , C0 2 R 5 , OR 5 , Ar 2 or Ar 3 ), Ar 2 or Ar 3 or a saturated C4-18 bicyclic ring or C3-11 saturated ring, optionally containing an oxygen or sulfur atom (said rings optionally substituted independently with one or more cyano, R 16 , Ar 2 or Ar 3 ); b) alkylene groups (optionally substituted with one or more R 7 groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocyclic group) wherein; Het represents -0-, -CH2-, -S(0) r , -(NH)- or -(N(Alk 1 -H))-; with the proviso that when Z is -(Alk 2 ) n -COR 5 , -(Alk 2 ) n -C0 R 5 or -(Alk 2 ) n -CO-thiopyridyl and R 5 is hydrogen, -Alk 1 -H, lower cycloalkyl, or adamantyl or when Z is -(Alk 2 ) n -CONR 4 R 15 and R 1 and R 5 are a) independently hydrogen, -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, - Ar 1 , benzyl, diphenylmethyl, triphenylmethyl or -(Alk 1 ) n -norbornyl; or b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocylic ring as herein before defined, Y is hydroxy; or ii) Y is hydrogen and Z is OR 5 , OCOR 5 , OCONR 1 4 R 1 5 , NR 5 'COR 5 , NR 5 'C0 2 R 5 , NR 5 CONR 1 4 R 15 or NR 5 CSR 4 R 1 5 ; and iii) Y and Z taken together are =0, =CH-(Alk 1 ) n -COR 5 , =CH-(Alk 1 ) n -C0 2 R 5 or =CH-(Alk 1 ) n -CONR 4 R 15 ; R 6 is hydrogen or methyl; or a pharmaceutically acceptable salt or solvate thereof. 2. A compound of Claim 1 which is a compound of formula (IA), (IB), (IC) or (ID) 3. A compound as claimed in Claim 1 or Claim 2 wherein R 3 is hydrogen, halogen, lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl. 4. A compound as claimed in Claim 3 wherein R 3 is hydrogen, halogen or lower alkyl. 5. A compound of Claim 1 or Claim 2 wherein R 3 is methyl, ethyl, cyano, iodo, bromo, chloro or dimethylaminomethyl. 6. A compound as claimed in any one of the preceding claims wherein R 4 is hydrogen, lower alkyl, lower cycloalkyl or lower cycloalkyl-lower alkyl. 7. A compound as claimed in Claim 6 wherein R 4 is hydrogen or lower alkyl. 8. A compound as claimed in any one of claims 1 to 5 wherein R 4 is methyl, ethyl, propyl, /-propyl, butyl, Abutylhexyl, 3-hydroxypropyl, propenyl, methylene- cyclopropyl, benzyl, 2-methoxyethyl, 2-acetic acid, 3-proponic acid, 5-pentanoic acid, 6-hexanoic acid, methyl-5-pentanoate, ethyl-6-hexanoate, 3- phthalimidylpropyl and 4-phthalimidylpropyl. 9. A compound according to any one of the preceding claims wherein X is -CH 2 -. 10. A compound as claimed in any one of the preceding claims wherein Y is hydrogen and Z is -(Alk 2 ) n -COR 5 , -(Alk 2 ) n -CONR 14 R 1 5 , -(Alk )-OCθ2R 5 , - (Alk 2 )-OCOR 5 , -(Alk )-NR 5 'COR 5 , -(Alk 2 ) n -CONR 5 NR 1 4 R 1 5 , -(Alk 2 )- NR 5 CONR 4 R 5 , or -(Alk 2 ) n -CONR 5 CONR 14 R 5 . 11. A compound as claimed in Claim 10 wherein Z is -COR 5 , -CONR 14 R 15 , -CH2OCO2R 5 , -CH2OCOR 5 , -CH2NR 5 'COR 5 , -CONR 5 NR R 15 , -CH2NR 5 CONR 1 R 1 5 or -CONR 5 CONR 1 4 R 15 . 12. A compound as claimed in Claim 11 wherein Z is -CONR 14 R 15 . 13. A compound as claimed in any one of the preceding claims wherein Ar 1 is a phenyl group. 14. A compound as claimed in any one of the preceding claims wherein Ar 2 is a phenyl group optionally substituted independently with one or more -Alk 2 -H (optionally substituted independently with one or more halogens), -OR 16 , -S(0)rR 7 , Ar 1 , methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogen groups. 15. A compound as claimed in any one of the preceding claims wherein R 1 4 is hydrogen or hydroxy, and R 1 5 is hydrogen, lower cycloalkyl (optionally substituted independently with one or more R 7 or Ar 2 groups), -(Alk 1 )-adamantyl, -(Alk 1 )n- myrantyl, -(Alk 1 ) n -norbornyl, -(Alk 1 ) n -fluorenyl, -(Alk 1 ) n -indanyl, -Alk 1 -H (optionally substituted independently with one or more lower cycloalkyl, SR 5 , OR 5 , Ar 2 or Ar 3 groups), Ar 2 or Ar 3 ; or R 14 and R 1 are carbon atoms, optionally substituted with one or more R 7 groups, taken together with the linking nitrogen to form a 5 to 7 atom heterocyclic group wherein Het represents -CH2-. 16. A compound as claimed in any one of the preceding claims wherein Ar 3 is an aromatic group of five or six ring atoms, at least one of which is O, N or S, optionally substituted independently with one or more Alk 1 H groups. 17. A compound as claimed in Claim 16 wherein Ar 3 is an optionally substituted pyrrolyl, thienyl, furyl or pyridyl group. 18. A compound as claimed in any one of the preceding claims wherein R 5 is hydrogen, lower alkyl optionally substituted independently with one or more Ar 2 groups, (lower alkyl)n-lower cycloalkyl, menthyl, adamantyl, norbornyl or Ar 2 . 19. A compound as claimed in any one of Claims 1 to 11 or 13 to 18 wherein Z is -COR 5 . 20. A compound as claimed in Claim 19 which is: 17β-(1 -Oxo-2-cyclohexylethyl)-6-azaandrost-4-en-3-one; 17β-(1 -Oxo-1 -(2,4-difluorophenyl)methyl)-6-azaandrost-4-en-3-one; 17β— (1 -Oxo-1 -(4-isopropoxyphenyl)methyl)-6-azaandrost-4-en-3-one; 17β-(1 -Oxo-3,3-diphenylpropyl)-6-azaandrost-4-en-3-one; or 17β-(1 -Oxo-1 -(2-norbornyl)methyl)-6-azaandrost-4-en-3-one or a pharmaceutically acceptable salt or solvate thereof. 21. A compound as claimed in any one of Claims 1 to 18 wherein Z is - CONR 14 R 15 , R 14 is hydrogen and R 15 is Ar 2 or a C3.1 saturated ring, optionally containing an oxygen or sulphur atom (optionally substituted independently with one or more R 7 or Ar 2 groups). 22. A compound as claimed in any one of the preceding claims wherein R 15 is a group of formula Ar 2a (-Ar 2a ) wherein R a and R are independently hydrogen, lower alkyl, trifluoromethyl, halogen or phenyl (optionally substituted with one or more halogens or branched C4-7alkyl) and R c is hydrogen or one or more halogens, or R 15 is a C3.11 saturated ring, optionally containing an oxygen or sulphur atom substituted with a group of formula Ar 2a . 23. A compound as claimed in Claim 22 wherein Ar 23 is a group of formula Ar 2aa where R aa is branched C4-7alkyl, trifluoromethyl or phenyl optionally substituted with one or more halogens; one of R a and R ca is branched C4-7alkyl, trifluoromethyl, halogen or phenyl optionally substituted with one or more halogens, and the other is hydrogen or halogen; and R da is hydrogen or halogen. 24. A compound as claimed in Claim 1 which is: 17β-N-((2,6-Di-/-propyl)phenyl)-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,4,6-trimethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Chloro-5-trifiuoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Dimethyl-4-bromo)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Dimethyl-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Dibromo-4-isopropyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,5-Ditrifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Diethyl-3,5-dichloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Diethyl-3-chloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,4,6-Trichloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Bromo-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl-6-methyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1 -(4-Chlorophenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Dibromo-4-chloro)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Diethyl-4-bromo)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Bromo-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-Chloro-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(5-Bromo-2-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(5-Chloro-2-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Diethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(4-Bromo-2- -butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl-5-cyano)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-(0-4-Tolyl)-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-(0-4-Chlorophenyl)-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4- en-3-one 17β-N-(2-Nitro-4-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-(0-Phenyl)-5-(1 ,1 -dimethyl)propyl)phenyl-carbamoyl-6-azaandrost-4-en- 3-one l7β-N-(2-Ethylsulfonyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-(3,5-Di-f-butyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-t-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2-f-Butyl-5-phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,6-Di-/-propyl)phenyl-carbamoyl-6-azaandrost-1 ,4-dien-3-one 17β-N-(2,6-Di-/-propyl)phenyl-carbamoyl-6-azaandrost-4-methyl-1 ,4-dien-3-one 17β-N-1 -(4-Trifluoromethylphenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-1-(4-Fluorophenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-Methoxyphenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-Methoxyphenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2,5-bis(Trifluoromethyl))phenyl-carbamoyl-6-azaandrost-4-methyl-4-en-3- one 17β-N-(2-t-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-methyl-4-en-3- one 17β-N-(2,5-Di-t-butyl)phenyl-carbamoyl-6-azaandrost-4-methyl-4-en-3-one 17β-N-(2-t-Butyl-5-(4-chlorophenyl))phenyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-t-Butylphenyl)cyclopentyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-t-Butylphenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1 -(4-Chlorophenyl)cyclopentyl-carbamoyl-6-azaandrost-4-methyl-4-en-3-one 17β-N-(2,5-bis(Trifluoromethyl))phenyl-carbamoyl-6-azaandrost-4-chloro-4-en- 3-one 17β-N-(2-t-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-chloro-4-en-3- one 17β-N-1 -(4- -Butylphenyl)cycloheptyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-f-Butylphenyl)cyclohexyl-carbamoyl-6-azaandrost-4-chloro-4-en-3-one 17β-N-(2,6-Diethyl-4-(4-chlorophenyl))phenyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-4-(4-f-Butylphenyl)tetrahydrothiopyranyl-carbamoyl-6-azaandrost-4-en-3- one 17β-N-9-(4-f-Butylphenyl)bicyclo[3.3.1]nonyl-carbamoyl-6-azaandrost-4-en-3-one l7β-N-4-(4-f-Butylphenyl)tetrahydropyranyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-1-(4-Chlorophenyl)cyclohexyl-carbamoyl-6-azaandrost-4-en-3-one 17β-N-(2- -Butyl-5-(4- -butyl)phenyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one or 17β-N-1 -(4-Chlorophenyl)cyclopentyl-carbamoyl-6-azaandrost-4-chloro-4-en-3-one or a pharmaceutically acceptable salt or solvate thereof. 25. 17β-N-(2-?-Butyl-5-trifluoromethyl)phenyl-carbamoyl-6-azaandrost-4-en-3-one or a pharmaceutically acceptable salt or solvate thereof. 26. A compound of formula ( wherein R 1 and R 2 are, i) independently hydrogen or lower alkyl and the bond between the carbons bearing R 1 and R 2 is a single or a double bond, or ii) taken together are a -CH2- group to form a cyclopropane ring, and the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is hydrogen or lower alkyl; R 4 is hydrogen or lower alkyl; Y is hydrogen; and Z is -COR 5 , -CONR 14 R 15 , -CH 2 OC0 2 R 5 , -CH 2 OCOR 5 , -CH 2 NR 5' COR 5 , -CONR 5 NR 14 R 15 , -CH 2 NR 5 CONR 14 R 5 , or -CON 5 CONR 1 R 15 wherein R 5 and R 5' are independently hydrogen, lower alkyl optionally substituted independently with one or more Ar 2 groups (lower alkyl) n -lower cycloalkyl, menthyl, adamantyl, norbornyl or Ar 2 ; Ar 2 is a phenyl group optionally substituted independently with one or more -Alk-H (optionally substituted independently with one or more halogens), -OR 16 , -S(0) r R 7 , phenyl, methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogen groups; Alk is lower alkylene, lower alkenylene or lower alkynylene; n is 0 or 1 ; r is O, 1 or 2; R 7 is -Alk-H, -(Alk)n-phenyl or lower cycloalkyl; R 6 is -Alk-H (optionally substituted independently with one or more halogens), lower cycloalkyl (optionally substituted independently with one or more halogens or -Alk-H (optionally substituted independently with one or more halogens)) or -(Alk) n - phenyl (wherein phenyl is optionally substituted independently with one or more lower alkoxy, cyano, halogen or -Alk-H groups (optionally substituted independently with one or more halogens)); R 14 is hydrogen or hydroxy, and R 15 is hydrogen, lower cycloalkyl (optionally substituted independently with one or more R 7 or Ar 2 groups), -(Alk)-adamantyl, -(Alk) n -myrantyl, -(Alk) n -norbornyl, -(Alk) n -fluorenyl, - (Alk)n-indanyl, -Alk-H (optionally substituted independently with one or more lower cycloalkyl, SR 5 , OR 5 , Ar 2 or Ar 3 groups), Ar 2 or Ar 3 , or R 14 and R 15 taken together with the linking nitrogen form a pyrrolidinyl, piperidinyl or perhydroazepinyl ring optionally substituted with one or more R 7 groups; Ar 3 is a pyrrolyl, thienyl, furyl or pyridyl group optionally substituted independently with one or more Alk-H groups; with the provisos that when Z is COR 5 , R 5 is substituted lower alkyl, lower alkyl lower cycloalkyl, menthyl, norbornyl or Ar 2 ; when Z is CONR 14 R 15 and R 15 is hydrogen, -Alk-H, lower cycloalkyl, lower alkoxy, adamantyl, phenyl, benzyl, diphenylmethyl, triphenylmethyl or -(Alk) n -norbornyl, R 14 is hydroxy; and when Z is CONR 14 R 15 and R 14 and R 15 taken together with the linking nitrogen form a pyrrolidinyl, piperidinyl or perhydroazepinyl ring, said ring is substituted with one or more lower alkenyl, lower alkynyl, -(Alk)n-phenyl or lower cycloalkyl groups; or a pharmaceutically acceptable salt or solvate thereof. 27. A compound of formula (I) wherein: R 1 and R 2 are, i) independently hydrogen or lower alkyl and the bond between the carbons bearing R 1 and R 2 is a single or a double bond, or ii) taken together are a -CH2- group to form a cyclopropane ring, and the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is hydrogen, -Alk 1 -H, -Alk 1 -H substituted with one or more halogens, lower cycloalkyl, lower cycloalkyl-lower alkyl, halogen,-(Alk 1 ) n -C0 H, -(Alk ) n -C0 2 R 7 , -(Alk 1 ) n -Ar 1 , -(Alk 1 ) n -CONR8R9, -(Alk 1 ) n -NR8R9, -(Alk ) n -S(0) r R 7 , -(Alk 1 ) n -CN, -(Alk 1 )-OH or -(Alk ) n -OR 7 ; wherein Alk 1 is lower alkylene, lower alkenylene or lower alkynylene, n is 0 or 1 , r is 0, 1 or 2, R 7 is -Alk -H, -(Alk 1 ) n -Ar 1 or lower cycloalkyl, R 3 and R 9 are independently hydrogen, -Alk 1 -H or lower cycloalkyl, Ar 1 is a homocyclic aryl group of 6 to 14 carbons; hydrogen, -Alk 1 -H, lower cycloalkyl, lower cycloalkyl-lower alkyl, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -phthalimidyl, (-Alk -)C0 2 H, -(Alk 1 ) n -C0 2 R 7 , -(Alk 1 ) n -Ar 1 , -(Alk 1 ) n -CONR8R9, -(Alk 1 ) n -NR8R9, -(Alk 1 ) n -OH or -(Alk 1 ) n -OR 7 ; X is, (CR 10 R 11 ) P (CR 12 R 13 ) q wherein R 1 , R 1 1 , R 12 and R 13 are independently hydrogen or lower alkyl, p and q are independently either 0 or 1 ; Y and Z are, i) Y is hydrogen or hydroxy and Z is -(Alk ) n -COR 5 , -(Alk 2 ) n -C0 2 R 5 , -(Alk 2 ) n -COSR 5 , -(Alk ) n -CONR 1 4 R 1 5 , -(Alk )-OCOR 5 , -(Alk )-OCONR 4 R 1 5 , -(Alk 2 )-OR 5 , -(Alk 2 )-NR 5 COR 5 , -(Alk )-NR 5 C0 2 R 5 , -(Alk )-NR 5 CONR 4 R 15 , -(Alk 2 )- n CONR 5 NR R 15 , -(Alk ) n -CONR 5 CONR 14 R 15 , (-Alk 2 -)NR 5 CSNR 14 R 15 or -(Alk 2 ) n -CONR 5 CSNR 1 R 15 ; wherein Alk 2 is (Cι _i2) alkylene, (C2-12) alkenylene or (C2-12) alkynylene, R 5 is hydrogen, -Alk 1 -H, -(Alk 1 ) n -(lower cycloalkyl), adamantyl, -(Alk 1 ) n -Ar 2 , -(Alk 1 ) n -Ar 3 , (lower cycloalkyl) n Ar 2 , (lower cycloalkyl) n Ar 3 or -Alk 1 - substituted independently with one or more CO2H, CO2R 7 , Ar 2 or Ar 3 groups; wherein Ar 2 is an aromatic group of 6 to 14 carbon ring atoms, optionally substituted with one or more Alk 1 , Alk 1 substituted with one or more halogens, -(Alk 1 ) n -OH, -(Alk 1 ) n -OR 7 , -(Alk ) n -C0 2 H, -(Alk 1 ) n -C0 2 R 7 , S(0) r R 7 or NR 8 R9, lower cycloalkyl, lower alkoxy, -(Alk 1 ) n -Ar 1 , methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano or halogen groups; Ar 3 is an aromatic group of 5 to 14 ring atoms, at least one of which is O, N or S, optionally substituted with one or more Alk 1 , lower cycloalkyl, lower alkoxy, CO2H, CO2R 7 , -(Alk 1 ) n -Ar 1 , cyano or halogen groups; R 1 4 and R 1 5 are, a) independently, hydrogen or -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, -(Alk 1 ) n -norbornyl, Ar 2 , Ar 3 , -Alk 1 - substituted independently with one or more SR 5 , COR 5 , CONR 5 R 7 , NR 5 COR 5 , NR 5 C0 2 R 5 , NR 5 CONHR 5 , CO2R 5 , OR 5 , Ar 2 or Ar 3 groups, -(Alk 1 ) n -fluorenyl, or -(Alk 1 ) n -indanyl; or b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocyclic group wherein; Het represents -0-, -CH 2 -, -S(0) r , -(NH)- or -(N(Alk 1 ))-; with the proviso that when Z is (-Alk 2 -) n COR 5 , (-Alk 2 -) n Cθ2R 5 or -(Alk ) n -CO- thiopyridyl and R 5 is hydrogen, -Alk 1 -H, lower cycloalkyl, -(Alk 1 ) n -Ar 1 , adamantyl or when Z is (-Alk 2 -) n CONR 1 R 5 and R 14 and R 1 5 are (a) independently hydrogen, -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, -Ar 1 , benzyl, diphenylmethyl, triphenylmethyl or -(Alk 1 ) n -norbornyl; or (b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocylic ring as herein before defined, Y is hydroxy; ii) Y is hydrogen and Z is OR 5 , OCOR 5 , OCONR 1 R 5 , NR 5 COR 5 , NR 5 C0 2 R 5 , NR 5 CONR 14 R 1 5 or NR 5 CSR R 15 ; iii) Y and Z taken together are =0, =CH-(Alk 1 ) n -COR 5 , =CH-(Alk 1 ) n -C0 R 5 or =CH-(Alk 1 ) n -CONR 1 4 R 1 5 ; R 6 is hydrogen or methyl; and pharmaceutically acceptable salts thereof. 28. A compound of formula (I): wherein R 1 and R 2 i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R 1 and R 2 is a single or a double bond, or ii) taken together are a -CH2- group forming a cyclopropane ring, and the bond between the carbons bearing R 1 and R 2 is a single bond; R 3 is, hydrogen, -Alk 1 -H (optionally substituted with one or more halogens), lower cycloalkyl, lower cycloalkyl-lower alkyl), halogen, -(Alk ) n -Cθ2H, -(Alk 1 ) n -Cθ2R 7 , -(Alk 1 ) n -Ar 1 , -(Alk ) n -CONR8R9, -(Alk 1 ) n -NR8R9, -(Alk 1 ) n -S(0) r R 7 , -(Alk 1 ) n -CN, -(Alk 1 )-OH, -(Alk 1 ) n -COR 7 or -(Alk 1 ) n -OR 7 ; wherein Alk 1 is lower alkylene, lower alkenylene or lower alkynylene, n is 0 or 1 , r is O, 1 or 2, R 7 is -Alk 1 -H, -(Alk 1 ) n -Ar 1 or lower cycloalkyl, R8 and R 9 are independently hydrogen, -Alk 1 -H or lower cycloalkyl, Ar 1 is a homocyclic aryl group of 6 to 14 carbons; R 4 is, hydrogen, -Alk 1 -H, lower cycloalkyl, lower cycloalkyl-lower alkyl, -(Alk ) n -S(0) r R 7 , -(Alk 1 ) n -phthalimidyl, -(Alk 1 )-Cθ2H, -(Alk 1 ) n -C0 2 R 7 , -(Alk ) n -COR 7 > -(Alk ) n -Ar 1 , -(Alk ) n -NR8R9, -(Alk 1 ) n -OH or -(Alk ) n -OR 7 ; Xis, wherein R 1 , R 11 , R 2 and R 13 are independently hydrogen or lower alkyl, p and q are independently either 0 or 1 ; and, i) Y is hydrogen or hydroxy and Z is -(Alk 2 ) n -COR 5 , -(Alk 2 ) n -C0 2 R 5 , -(Alk ) n -COSR 5 , -(Alk ) n -CONR 14 R 5 ,-(Alk )-OCθ2R 5 ,-(Alk 2 )-OCOR 5 ,-(Alk )-OCONR 14 R 15 , -(Alk 2 )-OR 5 , -(Alk )-NR 5 'COR 5 , -(Alk 2 )-NR 5 'C0 2 R 5 , -(Alk 2 )-NR 5 CONR 1 R 15 , -(Alk 2 ) n -CONR 5 NR 1 R 15 , -(Alk 2 ) n -CONR 5 CONR 14 R 15 , -(Alk 2 )- NR 5 CSNR 1 R 15 or -(Alk 2 ) n -CONR 5 CSNR 14 R 5 ; wherein Alk 2 is (Cι_i2) alkylene, (C2- 2) alkenylene or (C2-12) alkynylene, R 5 and R 5 ' are independently hydrogen, -Alk 1 -H (optionally substituted independently with one or more CO2H, CO2R 7 , Ar 2 , Ar 3 or cyano groups), -(Alk 1 ) n -(lower cycloalkyl (optionally substituted independently with one or more -Alk 1 -H groups)), adamantyl, norbornyl, Ar 2 , Ar 3 , (lower cycloalkyl)-Ar 2 or (lower cycloalkyl)-Ar 3 ; wherein Ar 2 is a homocyclic aromatic group of 6 to 14 carbon ring atoms (optionally substituted independently with one or more -Alk 2 -H (optionally substituted independently with one or more halogens), -(Alk 1 ) n -OH, -(Alk 1 ) n -OR 1 6 , -(Alk 1 ) n -Ar 3 , -(Alk ) n -C0 2 H, -(Alk 1 ) n -C0 2 R 7 , S(0) r R 7 , NR 3 S(0) r R 16 , NR 3 R9, CONR8R9, lower cycloalkyl, lower alkoxy, -(Alk 1 ) n -Ar 1 , methylenedioxy, ethylenedioxy, morpholino, thiomorpholino, cyano, nitro or halogens); wherein R 16 is -Alk 1 -H (optionally substituted independently with one or more halogens), lower cycloalkyl (optionally substituted independently with one or more halogens, or -Alk 1 -H (optionally substituted independently with one or more halogens)) or -(Alk 1 ) n -Ar 1 (wherein Ar 1 is optionally substituted independently with one or more, lower alkoxy, cyano groups, halogens or -Alk 1 -H (optionally substituted independently with one or more halogens)); Ar 3 is an aromatic group of 5 to 14 ring atoms, at least one of which is O, N or S, (optionally substituted independently with one or more -Alk 1 -H (optionally substituted independently with one or more halogens), lower cycloalkyl, lower alkoxy, CO2H, CO2R 7 , -(Alk 1 ) n -Ar 1 , cyano or halogen); R 1 4 and R 5 are, a) independently, hydroxy, hydrogen, -Alk 2 - H, lower cycloalkyl (optionally substituted independently with one or more cyano, R 16 , Ar 2 , Ar 3 ), lower alkoxy, -(Alk 1 ) n -adamantyl, -(Alk 1 ) n -myrantyl, -(Alk 1 ) n -norbornyl, -(Alk 1 ) n -fluorenyl, -(Alk 1 ) n -indanyl, -Alk 1 - H (optionally substituted independently with one or more, halogens, cyano, cycloalkyl, SR 5 , COR 5 , CONR 5 R 7 , NR 5 'COR 5 , NR 5 'Cθ2R 5 , NR 5 'CONHR 5 , CO2R 5 , OR 5 , Ar 2 or Ar 3 ), Ar 2 or Ar 3 : b) alkylene groups (optionally substituted with one or more R 7 groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocyclic group) wherein; Het represents -0-, -CH 2 -, -S(0) r , -(NH)- or -(N(Alk 1 -H))-; with the proviso that when Z is -(Alk 2 ) n -COR 5 , -(Alk 2 ) n -C0 2 R 5 or -(Alk 2 ) n -CO-thiopyhdyl and R 5 is hydrogen, -Alk 1 -H, lower cycloalkyl, -(Alk 1 ) n -Ar 1 , adamantyl or when Z is -(Alk 2 ) n -CONR 1 R 15 and R 14 and R 5 are a) independently hydrogen, -Alk 2 -H, lower cycloalkyl, lower alkoxy, adamantyl, - Ar 1 , benzyl, diphenylmethyl, triphenylmethyl or -(Alk 1 ) n -norbomyl; or b) carbon atoms, optionally substituted with one or more lower alkyl groups, taken together with the linking nitrogen to form a 4 to 8 atom heterocylic ring as herein before defined, Y is hydroxy; or ii) Y is hydrogen and Z is OR 5 , OCOR 5 , OCONR 4 R 1 5 , NR 5 'COR 5 , NR 5 'C0 2 R 5 , NR 5 CONR 1 R 1 5 or NR 5 CSR 14 R 1 5 ; and iii) Y and Z taken together are =0, =CH-(Alk 1 ) n -COR 5 , =CH-(Alk 1 ) n -C0 2 R 5 or =CH-(Alk 1 ) n -CONR 1 4 R 1 5 ; R6 hydrogen or methyl; and pharmaceutically acceptable salts thereof. 29. Intermediates of formula HNR 1 4 R 1 5 wherein R 1 4 is hydrogen and R 1 5 is Ar 2a or lower cycloalkyl substituted with a group of formula Ar 2a (wherein Ar 2a is as defined in Claim 22). 30. A compound selected from: 2-t-Butyl-5-trifluoromethylaniline, 1 -Amino-1 -(4-fluorophenyl)cyclopentane, 1 -Amino-1 -(4-trifluoromethylphenyl)cyclopentane, 1 -Amino-1 -(4-f-butylphenyl)cyclopentane, 1 -Amino-1 -(4-f-butylphenyl)cyclohexane, 1 -Amino-1 -(3,4-methylenedioxyphenyl)cyclohexane, 1 -Amino-1 -(1 -(4-biphenyl)-2,2-diethyl)cyclopropane, 1 -Amino-1 -(1 -(4-trifluoromethylphenyl)-2,2-diethyl)cyclopropane, 1 -Amino-1 -(4-t-butylphenyl)cycloheptane, 4-Amino-4-(4-f-butylphenyl)tetrahydrothiopyran, 9-Amino-9-(4-f-Butylphenyl)bicyclo[3.3.1]nonane, or 4-Amino-4-(4- -butylphenyl)tetrahydropyran or a salt thereof. 31. A pharmaceutical composition comprising a compound of formula (I) as defined in any one of Claims 1 to 28 together with a pharmaceutically acceptable carrier. 32. A method of inhibiting testosterone-5α-reductases comprising contacting testosterone-5α-reductases with a compound of formula (I) as defined in any one of Claims 1 to 28. 33. A method of treatment of androgen responsive or mediated disease comprising administering an effective amount of a compound of formula (I) as defined in any one of Claims 1 to 28 to a patient in need thereof in combination. 34. A method of treatment of androgen responsive or mediated disease comprising administering an effective amount of a compound of formula (I) as defined in any one of Claims 1 to 28 to a patient in need thereof in combination with an antiandrogen. 35. A method of treatment of androgen responsive or mediated disease comprising administering an effective amount of a compound of formula (I) as defined in any one of Claims 1 to 28 to a patient in need thereof in combination with an alpha 1 adrenergic receptor blocker. 36. A method of treatment of androgen responsive or mediated disease comprising administering an effective amount of a compound of formula (I) as defined in any one of Claims 1 to 28 to a patient in need thereof in combination with an anti- estrogen. 37. A method of treatment as claimed in any one of Claims 33 to 36 wherein the androgen responsive or mediated disease is benign prostatic hyperplasia, prostatitis, prostate cancer, acne, male pattern baldness and hirsutism. 38. Use of a compound of formula (I) as defined in any one of Claims 1 to 28 or a physiologically acceptable salt thereof in the manufacture of a medicament for the treatment or prevention of an androgen responsive or mediated disease. 39. A compound as defined in any one of Claims 1 to 28 for use in medicine. 40. A process for preparing a compound of formula (I) as defined in Claim 1 or a pharmaceutically acceptable salt or solvate thereof which comprises (A) reacting a compound of formula (IX) wherein JO is hydroxy or a protected hydroxy group, with an oxidising agent; or (B) for the preparation of compounds of formula (I) wherein X is -CH2CH2-, reacting a compound of formula (XV) with a reducing agent, and if necessary and/or desired subjecting the compound thus obtained to one or more further reactions comprising (i) converting the resulting compound of formula (I) or a salt or protected derivative thereof into another compound of formula (I); and/or (ii) removing any protecting group or groups; and/or (iii) converting a compound of formula (I) or a salt thereof into a pharmaceutically acceptable salt thereof. 41. A process as claimed in Claim 40 wherein a compound of formula (IX) wherein JO is a protected hydroxy group is deprotected and then oxidised with an appropriate oxidising agent to give a compound of formula (I) where R 4 is hydrogen. 42. A process as claimed in Claim 41 wherein the oxidising agent is Jones reagent. 43. A process as claimed in Claim 40 wherein a compound of formula (IX) wherein JO is a protected hydroxy group is treated with an acylating agent, deprotected and then oxidised with an appropriate oxidising agent to give a compound of formula (I) where R 4 is acyl. 44. A process as claimed in Claim 43 wherein the oxidising agent is pyridinium dichromate. 45. A process as claimed in Claim 44 wherein a compound of formula (XV) is reacted with triphenylphosphine to give a compound of formula (I) wherein X is - CH 2 CH 2 -.

Inventors: ANDREWS ROBERT CARL, CRIBBS CYNTHIA MARKERT, FRYE STEPHEN VERNON, HAFFNER CURT DALE, MALONEY PATRICK REED, ANDREWS, ROBERT, CARL, CRIBBS, CYNTHIA, MARKERT, FRYE, STEPHEN, VERNON, HAFFNER, CURT, DALE, MALONEY, PATRICK, REED
Applicants: ANDREWS ROBERT CARL, CRIBBS CYNTHIA MARKERT, FRYE STEPHEN VERNON, GLAXO INC, HAFFNER CURT DALE, MALONEY PATRICK REED, ANDREWS, ROBERT, CARL, CRIBBS, CYNTHIA, MARKERT, FRYE, STEPHEN, VERNON, GLAXO INC., HAFFNER, CURT, DALE, MALONEY, PATRICK, REED
Application year: 1993
Main classification: C07J3
IPC codes: A61K31, A61P37, C07C211, C07D309, C07D317, C07D335, C07J3, C07J63, C07J73, C07J75