5-(2-Chloroalkyl)-4-methylthiazoles, their preparation and their use, and intermediates for their preparation

Abstract: The invention relates to 5-(2-chloro-C₂₋₅-alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight-chain 2-chloro-C₂₋₅-alkyl group and a process for their preparation, which is characterized by (A1) reacting a 3-(2-chloro-C₂₋₅-alkyl)-3-thiocyanato-2-propanone of the general formula IV in an organic solvent with gaseous hydrogen chloride to obtain the corresponding 2-chloro-5-(2-chloro-C₂₋₅-alkyl)-4-methyl-1,3-thiazole of the general formula II or (A2) reacting a 3-(2-chloro-C₂₋₅-alkyl)-3-thiocyanato-2-propanone of the above formula IV with an aqueous mineral acid to obtain the corresponding 5-(2-chloro-C₂₋₅-alkyl)-2-hydroxy-4-methyl-1,3-thiazole of the general formula III and reacting the thus obtained compound of the formula III with a halogenating agent to obtain the corresponding 2-chloro-5-(2-chloro-C₂₋₅-alkyl)-4-methyl-1,3-thiazole of the above formula II, and (B) hydrogenating the compound of the general formula II to obtain the 5-(2-chloro-C₂₋₅-alkyl)-4-methyl-1,3-thiazole of the above general formula I. The invention further relates to intermediates for the above process, and pharmaceutical compositions comprising the compounds of formula I.

Description: The invention relates to novel 5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight-chain C 2-5 -alkyl group substituted by a chlorine atom in the 2-position, methods for their preparation, their pharmaceutical use, and suitable intermediates for their preparation. The compound of the formula Ia (Clomethiazole) is a therapeutically widely applied active ingredient of anticonvulsives and sedatives. The compound of the formula Ia was first described in 1935 [(J. Am. Chem. Soc. 57 , 1876 (1935)]. Its hydrochloride and ethane disulphonate salt are disclosed in GB-B-792 158. Its phosphate salt is known from US 3 639 415. The known methods for the preparation of the 1,3-thiazole derivatives unsubstituted in position 2 can be divided into two main types. When proceeding according to methods of the first type, the 2-unsubstituted thiazole is obtained in one step. According to methods of the second type thiazole derivatives containing an easily removable substituent in position 2 are prepared, and this substituent is removed in a second step. According to methods of the first type the thiazole ring is formed by reacting a halogenated ketone or aldehyde, which are halogenated in the α-position, or an aldehyde with thioformamide [Elderfield, R.C.: Heterocyclic Compounds, Vol. 5, page 516 (1957)] (Reaction Scheme A): R 1 and R 2 = alkyl, aryl or hydrogen X = halogen. This type of methods gives a good yield only in some cases [Buchman and Richardson: J. Am. Chem. Soc. 67 , 395 (1945); Erne, Ramirez and Burger: Helv. Chim. Acta 34 , 143 (1951)]. Further disadvantages of this method are the difficulty of preparing pure thioformamide and the instable character of thioformamide. To eliminate this difficulty the preparation of thioformamide was carried out in the reaction mixture itself from formamide and phosphorous pentasulphide, but this method was successful only in some cases [Ganapathi and Venkataraman: Proc. Indian Acad. Sci. 22 , 362 (1945)]. This method involves severe environment contamination risks because of the use of phosphorus pentasulphide. As the direct synthesis described above can hardly be realized on industrial scale, attention was paid to the indirect synthesis variants. One of these variants eliminates the amino group in position 2 via diazotization and the subsequent reduction of the diazonium group [Ganapathi and Venkataraman: Proc. Indian Acad. Sci 22 , 366 (1945)]. The 2-aminothiazole derivative necessary for this method is to be prepared in a separate step from α-halogenketone with thiourea [e.g. Tanida, Tamura and Sava: J. Pharm. Soc. Japan 74 , 652 (1954); C.A. 48 , 10737 (1945)] (Reaction Scheme B): On this route the target compounds can be obtained only in poor yields ranging between 30 and 60 %. A further possibility is the oxidative removal of the thio group in position 2 of the thiazole [GB-PS 492 637; Buchman, Reims and Sargnet: J. Org. Chem. 6 , 764 (1941)], or the desulphuration of the 2-mercaptothiazole derivative by boiling with Raney nickel at a great excess [Cook et al: J. Chem. Soc. 1954 (1947); Hurd and Rudner: J. Am. Chem. Soc. 73 , 5157 (1951)]. The required 2-mercaptothiazole has also to be prepared in a separate step from α-halogen-ketone and ammonium dithiocarbamate (cf. e.g. GB-B-492 637) (Reaction Scheme C): A disadvantage of this method is that for the preparation of ammonium dithiocarbamate carbon disulphide is needed, requiring a special workshop when prepared on industrial scale because of the great danger of fire. Further, the reagent and the by-products of the synthesis are contaminating the environment to a great extent. For the desulphuration with Raney nickel a great excess of nickel is required, which significantly increases the costs of the synthesis. A third possibility is the dehalogenation of the 2-halo-thiazole derivatives. For this purpose mostly zinc is used in an acetic medium [GB-B-456 751; Gibbs and Robinson: J. Chem. Soc. 925 (1945); Andersag and Westphal: Ber. 70 , 2035 (1937)]. Catalytic dehalogenation was described only in case of 2-bromo-thiazole-4-carboxylic acid [Erlenmeyer and Morel: Helv. Chim. Acta 25 , 1073 (1942)]. The 2-halo-thiazole compounds, i.e., the starting material of the process, are prepared from 2-aminothiazole derivatives by diazotization and Sandmayer reaction [e.g. Sava and Maeda: J. Pharm. Soc. Japan 76 , 301 (1956); C.A. 50 , 13875 (1956)] or from 2-hydroxy-thiazole derivatives with phosphoryl chloride (GB-B-456 751) or by ring closure of α-thiocyanatoketones with gaseous hydrochloric acid [Elderfield: Heterocyclic compounds, Vol. 5, p. 540 (1957)] (Reaction Schemes D and E): D: R 3 = NH 2 , OH X = halogen E: None of the above methods was used for the preparation of compounds of the general formula I of the present invention, nor for the preparation of the compound of the formula Ia. The compound of the formula Ia was prepared by chlorinating a suitable hydroxy compound with thionyl chloride (FR-B-3 815 M, GB-B-792 158 and NL-B-6 510 389) (Reaction Scheme F): A = alkylene group In case of Clomethiazole of the formula Ia a process was disclosed, according to which a suitable 2-mercapto derivative was oxidized with hydrogen peroxide (CH-B-200 248). The 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole of the formula IIa [Acta Pharm. Suec. 8 , p. 49 (1982)] and 5-(2-chloroethyl)-2-hydroxy-4-methyl-1,3-thiazole of the formula IIIa [Acta Pharm. Suec. 19 , p. 37 (1982)] are known compounds. None of these compounds, however, has been disclosed to be a suitable intermediate for the preparation of the compound of the formula Ia. In all of the general formulae R is as defined above. The present invention is based on the surprising finding that by reacting a 3-chloro-3-(2-chloro-C 2-5 -alkyl)-2-propanone (3-chloro-3-(2-chloro-C 2-5 -alkyl)-2-oxopropane) of the general formula V with an inorganic isothiocyanate and converting the 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanone of the general formula IV thus obtained into the 2-chloro-5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazole of the general formula II with gaseous hydrochloric acid in an organic solvent at a temperature ranging from 0°C to 100°C, then hydrogenating the latter in the presence of a metal catalyst in an organic solvent, 5-(2-chloro-C 2-5 -alkyl)-(4-methyl-1,3-thiazoles of the general formula I are obtained in good yields and with high purity by recovering it from the reaction mixture by known methods, preferably in the form of its hydrochloride. The compounds of the general formula I can be converted into acid addition salts by methods known per se. One may also consist in reacting compounds of the general formula IV with an aqueous mineral acid and converting the 5-(2-chloro-C 2-5 -alkyl)-2-hydroxy-4-methyl-1,3-thiazoles of the general formula III thus obtained into compounds of the general formula II by reaction with a halogenating agent, then by hydrogenating the latter in the presence of a palladium catalyst on charcoal or a palladium containing selenium catalyst into compounds of the general formula I as described above. It is the object of the present invention to provide novel 5-(2-chloroalkyl)-4-methyl-1,3-thiazoles, methods for their preparation, suitable intermediates and their preparation, and pharmaceutical compositions comprising the 5-(2-chloroalkyl)-4-methyl-1,3-thiazoles as active ingredients, exhibiting advantageous therapeutical properties, particularly as anticonvulsives and sedatives. The above object is achieved according to the independent claims. The dependent claims relate to preferred embodiments. The present invention provides 5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, and the acid addition salts thereof, 5-(2-chloroethyl)-4-methyl-1,3-thiazole (Clomethiazole) of the formula Ia and its acid addition salts being excluded. The invention further provides 2-chloro-5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazoles of the general formula II, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole of the formula IIa being excluded. These compounds are useful intermediates for the preparation of the compounds of formula I. The invention further provides 5-(2-chloro-C 2-5 -alkyl)-2-hydroxy-4-methyl-1,3-thiazoles of the general formula III, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, 5-(2-chloroethyl)-2-hydroxy-4-methyl-1,3-thiazole of the formula IIIa being excluded. These compounds are useful intermediates for the preparation of the corresponding compounds of formula II and thus for preparing the compounds of formula I. A further subject-matter of the present invention are 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanones of the general formula IV, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position. The compounds of the formula V are useful intermediates for preparing the compounds of formula IV, which on their part, represent usefule starting materials for the synthesis of the compounds of formula I. The process of the present invention for the preparation of the 5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, and the acid addition salts thereof, is characterized by (A1) reacting a 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanone of the general formula IV, wherein R is as defined above, in an organic solvent at a temperature ranging from 0°C to 100°C with gaseous hydrogen chloride to obtain the corresponding 2-chloro-5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazole of the general formula II wherein R is as defined above, or (A2) reacting a 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanone of the above formula IV with an aqueous mineral acid to obtain the corresponding 5-(2-chloro-C 2-5 -alkyl)-2-hydroxy-4-methyl-1,3-thiazole of the general formula III, wherein R is as defined above, and reacting the thus obtained compound of the formula III with a halogenating agent to obtain the corresponding 2-chloro-5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazole of the above formula II, and (B) hydrogenating the compound of the general formula II in the presence of a palladium catalyst on charcoal or a palladium containing selenium catalyst to obtain the 5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazole of the above general formula I, and optionally (C1) converting the compound of the above formula I or its hydrochloride into another acid addition salt thereof, or (C2) liberating the compound of the above formula I from an acid addition salt thereof. The process for the preparation of the 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanones of the general formula IV of the present invention is characterized by reacting a 3-chloro-3-(2-chloro-C 2-5 -alkyl)-2-propanone of the general formula V, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, with an inorganic thiocyanate, which is preferably selected from sodium thiocyanate, potassium thiocyanate and ammonium thiocyanate. In the above processes, R is preferably 2-chloroethyl. Advantageous embodiments of the above processes are characterized by one or more of the following features: (a) The hydrogenation of the compounds of formula II in step B is carried out in the presence of a metal catalyst in an organic solvent; (b) the hydrogenation of the compounds of formula II in step B is carried out in the presence of an acid binding agent, preferably in the presence of triethylamine; (c) the hydrogenation of the compounds of formula II in step B is carried out at or above atmospheric pressure, and preferably at a pressure of 0.7 MPa; (d) aliphatic alcohols, fatty acid esters formed with aliphatic alcohols, aromatic hydrocarbons and/or open-chain ethers are used as organic solvents in steps A1 and/or B; (e) the ring closure reaction of the compounds of the formula IV to the compounds of the formula II in step A1 is carried out in an anhydrous, water-immiscible solvent, which does not dissolve water, preferably in butyl acetate; (f) in step A2, aqueous phosphoric acid is used as aqueous mineral acid; (g) step A2 is carried out at a temperature ranging from 50 to 120 °C; (h) the halogenation of the compounds of the formula III in step A2 is carried out with use of phosphoryl chloride, phosphorus pentachloride and/or phosphorus trichloride as halogenating agents; (i) the halogenation of the compound of the formula III in step A2 is carried out in a halogenated aromatic solvent; (j) the reaction of the compound of the formula V with the inorganic thiocyanate for preparing the compounds of the formula IV is carried out in the presence of a solvent such as aliphatic alcohols, aliphatic ketones, fatty acid esters formed with aliphatic alcohols, or water. In accordance with an advantageous embodiment, the compounds of the formula IV are used as such, without isolating them from the reaction mixture from their preparation, for the synthesis of the compounds of formula I. The pharmaceutical compositions of the present invention comprise one or more of the compounds of formula I, together with usual pharmaceutical additives and excipients. They exhibit advantageous pharmacological properties, particularly as anticonvulsives and sedatives. The invention is based on the following finding: In the compounds of the general formula V the reactivity of the chlorine substituent in position α related to the carbonyl group surpasses that of the other chlorine substituent of the alkyl chain R to such an extent, that exclusively compounds of the general formula IV are obtained, and the formation of neither dithiocyanato-ketone nor isothiocyanato-ketone can be detected even in traces. The preparation of the compounds of the general formula II containing a thiazole ring from the compounds of the general formula IV has not been obvious because the literature does not comprise any hint to proceed this way. The removal of the chlorine substituent on the thiazole ring from the dichloro compounds of the general formula II by selective hydrogenation is surprising and not obvious, since the inactivity of the chlorine substituent at the alkyl chain could not be expected by a person skilled in the art. The conversion of the compounds of the general formula IV into the 2-hydroxy-1,3-thiazole derivatives of the general formula III preferably in the presence of phosphoric acid, further the halogenation of the compounds of the general formula III with a slight excess of the halogenating agent and in the most suitable solvent is accompanied with significant technological and environmental advantages. The above method described in the examples of the present invention is novel and represents an alternative synthesis route which cannot be derived from the known preparation methods of the Clomethiazole for the formula Ia. In the following an advantageous embodiment of the process of the invention will be explained with reference to the synthesis of the compound of the formula Ia. A compound of the formula IVa is prepared from a known compound of the formula [Acta Chem. Hung. 3 , 157 (1953)] in water, in an organic solvent or in a mixture of water and an organic solvent, by the aid of inorganic thiocyanates, preferably sodium, potassium or ammonium thiocyanate. Most preferably an organic solvent, e.g. acetone, methyl-ethyl-ketone, ethyl acetate, butyl acetate, methanol, ethanol, isopropyl acetate or ethyl propionate, is used. The reaction may be carried out at a temperature ranging from 20 to 100°C, preferably at the boiling point of the solvent, with an equivalent amount or with a slight (1 to 5 mol%) excess of the inorganic rhodanide . The dichloro derivative of the general formula IIa is obtained by reacting a compound of the formula IVa, dissolved in an organic solvent, with anhydrous gaseous hydrochloric acid. As a solvent most preferably water-immiscible ethers and esters, which do not dissolve water, e.g. ethylacetate, butyl acetate or diisopropylether are used. Lower aliphatic alcohols may preferably be used, e.g. methanol, ethanol, n-propanol, isopropanol or butanol, lower fatty acids, e.g. acetic acid or propionic acid, or halogenated hydrocarbons, e.g. carbontetrachloride, chloroform or 1,2-dichloroethane may also be preferred. The reaction is carried out at a temperature ranging from 0 to 100°C, preferably from 0 to 40°C. The selective hydrogenation of the compound of the formula IIa is carried out in the presence of a metal catalyst in an organic solvent. The metal catalyst is preferably palladium on active charcoal or palladium containing selenium (Examples 1, 3 and 5 of published PCT-application No. 89/2429) and a catalyst containing rhodium or ruthenium may also be applied. As an organic solvent lower aliphatic alcohols, e.g. methanol, ethanol, n-propanol or isopropanol, lower esters of aliphatic carboxylic acids, e.g. ethyl acetate, butyl acetate, methyl acetate, isopropyl acetate or ethylpropionate, aromatic hydrocarbons, e.g. benzene or toluene, or open-chained ethers, e.g. cellosolve, methylcellosolve, butylcellosolve, dimethylcellosolve or diglyme) can be used. Hydrogenation may be carried out at atmospheric pressure or at a slight overpressure (0.05-0.7 MPa). The liberated hydrochloric acid is bound by the forming thiazole derivative of the formula Ia, then it can also be recovered in the form of a hydrochloride of the formula Ia. During hydrogenation an acid binding agent, such as alkali hydroxides, e.g. sodium or potassium hydroxide, or organic bases, e.g. triethylamine, may be applied, whereby the basic compound of the formula Ia itself is obtained. In the preparation of the compound of the formula IIIa α-thiocyanato-ketone of the formula IVa is treated with aqueous phosphoric acid, in this case no organic solvent is needed and no corrosion problem arises as opposed to the known acetic acid - concentrated sulfuric acid or acetic acid - concentrated hydrochloric acid reagents. Further, no environmentally damaging by-products are formed during the processing of the reaction mixture. The reaction is carried out at a temperature ranging from 50 to 120°C, preferably from 90 to 100°C. When halogenating the compounds of the formula IIIa preferably phosphorus halides, e.g. phosphoryl chloride, phosphorus pentachloride or phosphorus trichloride are used as halogenating agent. As an organic solvent preferably halogenated aliphatic hydrocarbons, e.g. 1,2-dichloroethane, 1,1,2-trichloroethane, trichloroethylene or 1,1,2,2-tetrachloroethane, aromatic hydrocarbons, e.g. benzene, toluene or xylene, specially preferably halogenated aromatic hydrocarbons, e.g. chlorobenzene, 1,2-dichlorobenzene or 1,2,4-trichlorobenzene may be used. The reaction is carried out at a temperature ranging from 80 to 150°C, preferably from 100 to 140°C. The other compounds of the general formulae I, II, III and IV can preferably be prepared by the methods described above. The preparation of the compounds of the general formula V is disclosed in the examples where no literature reference is available. The present invention is elucidated in more detail in the following non-limiting examples. Example 1 77.8 g (0.5 moles) of 3,5-dichloro-2-pentanone [prepared according to Acta Chim. Hung. 3 , 157 (1953)] are added to the solution of 49.9 g (0.513 moles) of potassium rhodanide in 500 ml of acetone. The solution is boiled under stirring for 4 hours. The reaction mixture is cooled to room temperature and the precipitated potassium chloride is filtered off and washed with acetone. The filtrate is evaporated, the residue is dissolved in benzene and the benzene solution is washed 3 times with water. After drying with sodium sulphate, the benzene is distilled off. 62.2 g (93%) of 3-thiocyanato-5-chloro-2-pentanone are obtained in the form of a red oil. After distilling at a lower pressure a faint yellow oil is obtained, its boiling point is 112°C at a pressure of 26.6 Pa, n D 20 =1.5110. According to infrared spectrum it does not contain any isothiocyanate. Analysis for the formula C 6 H 8 ClNOS: calculated: C%=40.56, H%=4.53, N%=7.88, Cl%=19.95, S%=18.04; found: C%=41.25, H%=4.59, N%=8.13, Cl%=20.32, S%=17.90; The NMR data support the structure. Example 2 A solution of 155.5 g (1 mole) of 3,5-dichloro-2-pentanone with 83 g (1.024 moles) of sodium rhodanide in 1 litre of methylethylketone is boiled for 1 hour under stirring. Then the procedure described in Example 1 is followed. 171 g (96.2%) of 5-chloro-3-thiocyanato-2-pentanone are obtained, which after distillation identical in all respect with the product of Example 1. Example 3 A suspension of 7.8 g (0.05 moles) of 3,5-dichloro-2-pentanone with 3.9 g (0.051 moles) of ammonium rhodanide in 50 cm 3 of methylethylketone is boiled for 1 hour under stirring. Then the procedure described in Example 1 is followed. 8.5 g (95.5%) of 5-chloro-3-thiocyanato-2-pentanone are obtained, which after distillation is identical in all respect with the product of Example 1. Example 4 A solution of 7.8 g (0.05 moles) of 3,5-dichloro-2-pentanone with 4.15 g (0.051 moles) of sodium rhodanide in 50 cm 3 of ethanol is boiled for 2 hours under stirring. Then the procedure described in Example 1 is followed. 7.7 g (87%) of 5-chloro-3-thiocyanato-2-pentanone are obtained, which is identical in all respect with the product of Example 1 after distillation. Example 5 To a solution of 4.86 g (0.05 moles) of potassium rhodanide in 10 cm 3 of water 7.8 g (0.05 moles) of 3,5-dichloro-2-pentanone are added, and the reaction mixture is stirred for 3 hours at a temperature of 80°C. After cooling the precipitating oil is separated and the aqueous phase is shaken twice with 20 cm 3 of benzene each. The separated oil is combined with the benzene solution, washed with water and dried over sodium sulfate. After filtering and evaporating 7.4 g (83.5%) of 5-chloro-3-thiocyanato-2-pentanone are obtained, which after distillation is identical in all respect with the product of Example 1. Example 6 A solution of 17.7 g (0.1 mole) of 5-chloro-3-thiocyanato-2-pentanone in 170 cm 3 of anhydrous ethylacetate is saturated with gaseous hydrochloric acid. The temperature of the reaction mixture is kept below 10°C by ice-cooling. The solution obtained is let to stand overnight at room temperature. The next day the solution is poured onto ice and its pH-value is adjusted to a value between 6 and 7 with a 20% sodium hydroxide solution. The phases are separated and the aqueous phase is shaken with 150 ml of ethyl acetate. The combined ethyl acetate solutions are washed neutral with water and a 5% sodium hydrogen carbonate solution and dried over sodium sulphate. After distilling off the solvent, the residue is distilled under reduced pressure to obtain 14.8 g (75.5%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole in the form of a faint yellow oil. The boiling point is 104°C at a pressure of 40 Pa, n D 20 =1.5505. Analysis for the formula C 6 H 7 Cl 2 NS: calculated: C%=36.70, H%=3,39, N%=7.14, Cl%=36.15, S%=16.35; found: C%=37.01, H%=3.71, N%=7.48, Cl%=35.40, S%=15.97; The IR and NMR data support the structure. The content of the product is more than 95% determined by gas chromatography. Example 7 25 g (0,14 moles) of 5-chloro-3-thiocyanato-2-pentanone are dissolved in 170 cm 3 of butyl acetate saturated with gaseous hydrochloric acid at 0°C. Into the reaction mixture gaseous hydrochloric acid is introduced until saturation under cooling with ice, keeping the temperature below 10°C. After saturation the reaction mixture is stirred for further 20 minutes under cooling, then the temperature is slowly increased to 40°C. The reaction mixture is stirred at this temperature for 20 minutes and after cooling to room temperature it is poured onto ice. The pH-value of the mixture is adjusted between 7 and 8 by adding a 40% sodium hydroxide solution. The mixture is processed further as described in Example 6. 20.8 g (76%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained, which is identical in every respect with the product obtained in Example 6. Example 8 One proceeds as described in Example 7 with the difference that instead of butyl acetate abs. ethanol is used. After the termination of the reaction the reaction mixture is evaporated in vacuo and to the residue water and 20% sodium hydroxide solution are added to a pH-value of 7. Furtheron one proceeds as described in Example 7. 17 g (62%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained which is identical in every respect with the product obtained in Example 6. Example 9 One proceeds as described in Example 6 with the difference that instead of ethyl acetate diisopropylether is used. 14 g (74%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained which is identical in every respect with the product obtained in Example 6. Example 10 One proceeds as described in Example 8 with the difference that instead of abs. ethanol glacial acetic acid is used. 20.2 g (73.5%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained, which is identical in every respect with the product obtained in Example 6. Example 11 One proceeds as described in Example 6 with the difference that instead of ethyl acetate carbon tetrachloride is used. 12 g (61%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained, which is identical in every respect with the product obtained in Example 6. Example 12 355,3 g (2 moles) of distilled 5-chloro-3-thiocyanato-2-pentanone are added into 360 cm 3 of 85% phosphoric acid under stirring. The temperature of the reaction mixture is increased to 95°C in water bath within about 1 hour and then it is stirred for half and hour between 95 to 100°C. The brown solution is cooled to 20°C and poured into 660 cm 3 of water. The precipitated beige crystals are removed by suction after a stirring for half an hour, washed neutral with water and dried in vacuo at a temperature of 60°C. 337 g (95%) of pale beige 5-(2-chloroethyl)-2-hydroxy-4-methyl-1,3-thiazole are obtained, m.p.: 151-152°C. After recrystallization from benzene the melting point is 157-158°C. Analysis as calculated for C 6 H 8 ClNOS: calculated: C%=40.56, H%=4.53, N%=7.88, S%=18.04, Cl%=19.95; found: C%=40.74, H%=4.52, N%=7.57, S%=17.94, Cl%=19.68. The structure of the compound is confirmed also by the IR and NMR data. Example 13 One proceeds as described in Example 12 using non-distilled 5-chloro-3-thiocyanato-2-pentanone content: 80%, determined by gas chromatography). 234 g (66%) of 5-(2-chloroethyl)-2-hydroxy-4-methyl-1,3-thiazole are obtained, which melts at 141 to 146°C. Example 14 A suspension of 177.6 g (1 mole) of 5-(2-chloroethyl)-2-hydroxy-4-methyl-1,3-thiazole in 530 cm 3 of anhydrous chlorobenzene is heated to 100 °C under stirring. 306.6 g (2 moles) of phosphoryl chloride are flown into the solution in 30 minutes, then it is stirred at a temperature of 125-130°C until the formation of hydrogen chloride ceases (about 2 hours). The reaction mixture is cooled to 20°C, then it is poured onto 1.5 kg of ice. The phases are separated, the aqueous phase is extracted twice with 200 cm 3 of chlorobenzene each. The combined phases containing the chlorobenzene are washed acid-free with water and then with a 5% sodium hydrogen carbonate solution and then evaporated under reduced pressure. The brown residue is fractionated in vacuo. 145 g (74%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained. The boiling point is 102°C at a pressure of 53.2 Pa, n 20 D =1.5512, n 30 D =1,5468. Purity: 99.4% (by gas chromatography). Analysis as calculated for C 6 H 7 Cl 2 NS: calculated: C%=36.70, H%=3.59, N%=7.14, Cl%=36.15, S%=16.35; found: C%=36.98, H%=3.68, N%=7.28, Cl%=35.70, S%=16.05. The structure of the compound is confirmed also by the IR and NMR data. Example 15 To a solution of 63 g (0.32 moles) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole in 630 cm 3 of a 96% ethanol 9 g of a wet palladium on charcoal catalyst (palladium content: 8%) are added. The mixture is hydrogenated at atmospheric pressure The termination of the reaction is indicated by the cease of the hydrogen consumption. After filtering off the catalyst the solution is evaporated, the residue is dissolved in water and the solution is neutralized with sodium hydrogen carbonate (pH 7). The separated oil is extracted with chloroform. The residue after the evaporation of the chloroform solution is distilled under reduced pressure. 47 g (91%) of 4-methyl-5-(2-chloroethyl)-thiazole are obtained. Its boiling point is 105°C at a pressure of 0.93 KPa, n D 20 =1.5430. Its active agent content is 98.8%, determined by gas chromatography. The infrared and NMR spectra of the product is identical with that of the authentic sample. Example 16 One proceeds as described in Example 15 with the difference that the hydrogenation is carried out at a pressure of 0.3 MPa. 46.5 g (90%) of 5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained which is identical in every respect with the product obtained in Example 15. Example 17 One proceeds as described in Example 15 with the difference that instead of ethanol methanol is used. 42.9 g (83%) of 5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained which is identical in every respect with the product obtained in Example 15. Example 18 One proceeds as described in Example 15 with the difference that after evaporation the residual solid substance is separated. 61.5 g (97%) of 5-(2-chloroethyl)-4-methyl-1,3-thiazole hydrochloride are obtained. Its melting point after recrystallization from anhydrous ethanol is 136-137°C. Analysis as calculated for C 6 H 9 Cl 2 NS: calculated: C%=36.37, H%=4.58, N%=7.07, Cl%=35.79; found: C%=36.18, H%=4.52, N%=7.10, Cl%=35.89. Example 19 One proceeds as described in Example 15 with the difference that acetone is added to the solution obtained after filtering off the catalyst and the precipitating solid substance is filtered 59.4 g (93.7%) of 5-(2-chloroethyl)-4-methyl-1,3-thiazole hydrochloride are obtained. Its melting point is 137-137.5°C after recrystallized in anhydrous ethanol. Analysis as calculated for C 6 H 9 Cl 2 NS: calculated: C%=36.37, H%=3.59, N%=4.58, Cl%=35.79; found: C%=36.17, H%=4.51, N%=7.12, Cl%=35.89. Example 20 One proceeds as described in Example 15 with the difference that as catalyst 9 g of palladium on charcoal containing selenium are added. This catalyst has been prepared according to Example 5 of the PCT-application published under No. WO-89/02429 (page 12). 46.2 g (89.4%) of 5-(2-chloroethyl)-4-methyl-1,3-thiazole are obtained which is identical with the product obtained in Example 15 in respect of its physical constants and active agent content. Example 21 83 g (1.024 moles) of sodium rhodanide are added to a solution of 155.5 g (1 mole) of 3,5-dichloro-2-pentanone in 1 litre of butyl acetate. The suspension is stirred for 4 hours in hot water bath. After cooling the sodium chloride formed is filtered off and the filtrate is washed 3 times with water. After drying over sodium sulfate the butyl acetate is distilled off. 168 g (94%) of 5-chloro-3-thiocyanato-2-pentanone are obtained in the form of red oil. After distillation this product is identical with the product obtained in Example 1. Example 22 83 g (1.024 moles) of sodium rhodanide are added to a solution of 155.5 g (1 mole) of 3,5-dichloro-2-pentanone in 1 litre of butyl acetate The suspension is stirred for 4 hours in hot water bath. After cooling the sodium chloride formed is filtered off and the filtrate is washed 3 times with water and dried over sodium sulfate. After filtering off the drying agent the light red-brown filtrate is cooled under 10°C by icy water and saturated with gaseous hydrochloric acid under stirring, keeping the temperature under 10°C. After saturation the reaction mixture is stirred for further 20 minutes under cooling, then the temperature is increased slowly to 40°C. The reaction mixture is stirred at this temperature for 20 minutes and poured onto ice after cooling down to room temperature. The phases are separated, the aqueous phase is shaken with 150 cm 3 of butyl acetate The combined butyl acetate solutions are washed neutral with water and 5% sodium hydrogen carbonate solution, then dried over sodium sulfate. After distilling off the solvent the residue is distilled off under reduced pressure to obtain 121 g (66%) of 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole in the form of pale yellow oil, which is identical in every respect with the product obtained in Example 1. Example 23 One proceeds as described in Example 1 by using 8.45 g (0.05 moles) of 3,5-dichloro-2-hexanone, 5 g of potassium rhodanide and 50 cm 3 of acetone. 8.9 g (93%) of 5-chloro-3-thiocyanato-2-hexanone are obtained. After distillation under reduced pressure it is a pale yellow oil, its boiling point is 107-108°C at a pressure of 53.3 Pa, n D 20 =1.5050. According to the IR spectrum data the product contains no isothiocyanate. Analysis as calculated for C 7 H 10 ClN0S: calculated: C%=43.82, H%=5.25, N%=7.30, Cl%=18.50, S%=16.72; found: C%=43.57, H%=5.96, N%=7.61, Cl%=18.36. S%=16.58. Example 24 One proceeds as described in Example 1 by using 18.3 g (0.1 mole) of 3,5-dichloro-2-heptanone, 10 g (0.102 moles) of potassium rhodanide and 100 cm 3 of acetone. 19.1 g (93%) of 5-chloro-3-thiocyanato-2-heptanone are obtained. After distillation under reduced pressure it is a pale yellow oil, its boiling point is 124°C at a pressure of 53.3 Pa, n D 20 =1.4983. According the IR spectrum data the product contains no isothiocyanate. Analysis as calculated for C 8 H 12 ClN0S: calculated: C%=46.70, H%=5.88, N%=6.80, Cl%=17.23, S%=15.58; found: C%=46.93, H%=5.69, N%=6.68, Cl%=16.87. S%=13.37. Example 25 One proceeds as described in Example 7 by using 9.6 g (0.05 moles) of 5-chloro-3-thiocyanato-2-hexanone and 55 cm 3 of butyl acetate. 7.7 g (80%) of 2-chloro-5-(2-chloropropyl)-4-methyl-1,3-thiazole are obtained in the form of a colourless liquid. Its boiling point is 96°C at a pressure of 66.6 Pa, n D 20 =1.5400. Analysis as calculated for C 7 H 9 Cl 2 NS: calculated: C%=40.00, H%=4.31, N%=6.66, Cl%=33.74, S%=15.26; found: C%=39.75, H%=4.24, N%=6.70, Cl%=33.68. S%=14.82. The structure of the compound is confirmed by the IR and NMR data. Example 26 One proceeds as described in Example 7 by using 10.25 g (0.05 moles) of 5-chloro-3-thiocyanato-2-heptanone and 55 cm 3 of butyl acetate. 8.9 g (79.5%) of 2-chloro-5-(2-chlorobutyl)-4-methyl-1,3-thiazole are obtained in the form of a colourless liquid. Its boiling point is 108°C at a pressure of 53.2 Pa, n D 20 =1.5263. Analysis as calculated for C 8 H 11 Cl 2 NS: calculated: C%=42.86, H%=4.94, N%=6.28, Cl%=31.63, S%=14.30; found: C%=43.07, H%=4.79, N%=6.13, Cl%=31.33. S%=14.20. The structure of the compound is confirmed by the IR and NMR data. Example 27 One proceeds as described in Example 15 by using 7 g (0.033 moles) of 2-chloro-5-(2-chloropropyl)-4-methyl-1,3-thiazole, 60 cm 3 of 96% ethanol and 1 g of wet palladium on charcoal catalyst (palladium content: 8%). 5 g (86%) of 5-(2-chloropropyl)-4-methyl-1,3-thiazole are obtained in the form of a colourless liquid. Its boiling point is 78°C at a pressure of 40 Pa, n D 20 =1.5330. Analysis as calculated for C 7 H 10 ClNS: calculated: C%=47.30, H%=5.73, N%=7.97, Cl%=20.17, S%=18.24; found: C%=47.53, H%=5.25, N%=7.63, Cl%=20.46. S%=18.18. The structure of the compound is confirmed by the IR and NMR data. Example 28 One proceeds as described in Example 15 by using 5.3 g (0.024 moles) of 2-chloro-5-(2-chlorobutyl)-4-methyl-1,3-thiazole, 50 cm 3 of 96% ethanol and 0.9 g of wet palladium on charcoal catalyst (palladium content: 8%). 3.7 g (81%) of 5-(2-chlorobutyl)-4-methyl-1,3-thiazole are obtained in the form of a colourless liquid. Its boiling point is 94°C at a pressure of 66.5 Pa, n D 20 =1.5263. Analysis as calculated for C 8 H 12 ClNS: calculated: C%=50.64, H%=6.37, N%=7.38, Cl%=18.69, S%=16.90; found: C%=49.98, H%=6.21, N%=7.12, Cl%=18.20. S%=17.08. The structure of the compound is confirmed by the IR and NMR data. Example 29 One proceeds as described in Example 12 by using 15.3 g (0.05 moles) of 5-chloro-3-thiocyanato-2-hexanone and 16 cm 3 of 83% phosphoric acid. 11.2 g (73%) of 5-(2-chloro-propyl)-2-hydroxy-4-methyl-1,3-thiazole are obtained, which melts at 91-93°C. Analysis as calculated for C 7 H 10 ClN0S: calculated: C%=43.85, H%=5.25, N%=7.30, Cl%=18.49, S%=16.72; found: C%=43.52, H%=5.12, N%=7.05, Cl%=18.50. S%=16.82. The structure of the compound is confirmed by the IR and NMR data. Example 30 One proceeds as described in Example 12 by using 13.3 g (0.064 moles) of 5-chloro-3-thiocyanato-2-heptanone and 14 cm 3 of 85% phosphoric acid. 9.5 g (71.5%) of 5-(2-chloro-butyl)-2-hydroxy-4-methyl-1,3-thiazole are obtained, which melts at 84-85°C. Analysis as calculated for C 8 H 12 ClN0S: calculated: C%=46.70, H%=5.88, N%=6.80, Cl%=17.23, S%=15.58; found: C%=46.04, H%=5.61, N%=6.20, Cl%=16.98. S%=15.30. The structure of the compound is confirmed by the IR and NMR data. Example 31 One proceeds as described in Example 14 by using 9.7 g (0.05 moles of 5-(2-chloro-propyl)-2-hydroxy-4-methyl-1,3-thiazole, 15,3 g (0.1 mole) of phosphoryl chloride and 26 cm 3 of anhydrous chlorobenzene. 8.4 g (83.3%) of 2-chloro-5-(2-chloro-propyl)-4-methyl-1,3-thiazole are obtained in the form of a colourless oil. Its boiling point is 102°C at a pressure of 80 Pa, n D 20 =1.5400. Analysis as calculated for C 7 H 9 Cl 2 NS: calculated: C%=40.00, H%=4.31, N%=6.66, Cl%=33.74, S%=15.26; found: C%=39.85, H%=4.35, N%=6.76, Cl%=33.65. S%=14.95. The structure of the compound is confirmed by the IR and NMR data. Example 32 One proceeds as described in Example 14 by using 7.4 g (0.036 moles) of 5-(2-chlorobutyl)-2-hydroxy-4-methyl-1,3-thiazole, 11 g (0,072 moles) of phosphoryl chloride and 19 cm 3 of anhydrous chlorobenzene. 6.7 g (83.3%) of 2-chloro-5-(2-chlorobutyl)-4-methyl-1,3-thiazole are obtained in the form of a colourless oil. Its boiling point is 108°C at a pressure of 53.2 Pa, n D 20 =1.5352. Analysis as calculated for C 8 H 11 Cl 2 NS: calculated: C%=42.86, H%=4.94, N%=6.28, Cl%=31.63, S%=14.30; found: C%=42.98, H%=4.81, N%=6.21, Cl%=31.44. S%=14.20. The structure of the compound is confirmed by the IR and NMR data. Preparation of further starting materials Example 1 3,5-dichlorohexanone A mixture of 17.7 g (0.1 mole) of α-chloro-α-aceto-γ-valerolactone [prepared according to J. Am. Chem. Soc. 67 , 398 (1945)] and 35 cm 3 of abs. hydrochloric acid is heated slowly to 90°C under stirring and is stirred at this temperature until the gas formation stops. After cooling the dark solution is poured into 100 cm 3 of water, the separating oil is extracted with chloroform. The chloroform containing solution is washed by 50 cm 3 of 5% sodium hydrogen carbonate solution. After evaporation the residual oil is distilled in vacuo. 5 g (30%) of 3,5-dichloro-2-hexanone are obtained in the form a colourless liquid. The boiling point is 38°C at a pressure of 26.6 Pa. Analysis as calculated for C 6 H 10 Cl 2 0: calculated: C%=42.62, H%=5.96, Cl%=41.94; found: C%=42.77, H%=5.76, Cl%=41.50. The structure of the compound is confirmed by the IR and NMR data. Example 2 3,5-Dichloro-2-heptanone a) α-Chloro-α-acetyl-γ-ethyl-γ-butyrolactone Into a solution of 58.2 g (0.37 moles) of α-acetyl-γ-ethyl-γ-butyrolactone [prepared according to J. Pharm. Sci. 52 , 733 (1963)] in 60 cm 3 benzene 50 g of (0.37 moles) of sulphuryl chloride are added dropwise under stirring and cooling in 2 hours, keeping the temperature of the reaction mixture between 5 and 10°C. After completing the addition the reaction mixture is let to warm to room temperature and stirred at this temperature until the gas formation ceases. Then it is poured into 400 cm 3 of water, the phases are separated and the water is extracted with 200 cm 3 of benzene. The benzene containing solution is washed with 100 cm 3 of 5% sodium hydrogencarbonate solution. After evaporation the residual oil is distilled in vacuo. The title compound is obtained in the form of a colourless liquid in an amount of 58.9 g (82.5%), its boiling point is 91°C at a pressure of 80 Pa, n D 20 =1,4623. Analysis as calculated for C 8 H 11 Cl0 3 : calculated: C%=50.40, H%=5.81, Cl%=18.60; found: C%=50.63, H%=5.55, Cl%=18.84. b) 3,5-dichloro-2-heptanone The title compound is prepared according to the method described in Example 1 starting from 49 g (0.26 moles) of α-chloro-α-acetyl-γ-ethyl-γ-butyrolactone and 98 cm 3 of abs. hydrochloric acid. After distillation 22 g (47%) of the title compound is obtained. Its boiling point is 68-70°C at a pressure of 133.3 Pa, n D 20 =1,4600. Analysis as calculated for C 7 H 12 Cl 2 0: calculated: C%=45.91, H%=6.60, Cl%=38.73; found: C%=45.66, H%=6.55, Cl%=38.90.

Claims: 5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight -chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, and the acid salts thereof, 5-(2-chloroethyl)-4-methyl-1,3-thiazole (Clomethiazole) of the formula Ia and its acid salts being excluded. 2-Chloro-5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazoles of the general formula II, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, 2-chloro-5-(2-chloroethyl)-4-methyl-1,3-thiazole of the formula IIa being excluded. 5-(2-chloro-C 2-5 -alkyl)-2-hydroxy-4-methyl-1,3-thiazoles of the general formula III, wherein R is a staight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, 5-(2-chloroethyl)-2-hydroxy-4-methyl-1,3-thiazole of the formula IIIa being excluded. 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanones of the general formula IV, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position. Process for the preparation of 5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazoles of the general formula I, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, and the acid addition salts thereof, characterized by (A1) reacting a 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanone of the general formula IV, wherein R is as defined above, in an organic solvent with gaseous hydrogen chloride at a temperature ranging from 0°C to 100°C to obtain the corresponding 2-chloro-5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazole of the general formula II wherein R is as defined above, or (A2) reacting a 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanone of the above formula IV with an aqueous mineral acid to obtain the corresponding 5-(2-chloro-C 2-5 -alkyl)-2-hydroxy-4-methyl-1,3-thiazole of the general formula III, wherein R is as defined above, and reacting the thus obtained compound of the formula III with a halogenating agent to obtain the corresponding 2-chloro-5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazole of the above formula II, and (B) hydrogenating the compound of the general formula II in the presence of a palladium catalyst on charcoal or a palladium containing selenium catalyst to obtain the 5-(2-chloro-C 2-5 -alkyl)-4-methyl-1,3-thiazole of the above general formula I, and optionally (C1) converting the compound of the above formula I or its hydrochloride into another acid addition salt thereof, or (C2) liberating the compound of the above formula I from an acid addition salt thereof. Process for the preparation of the 3-(2-chloro-C 2-5 -alkyl)-3-thiocyanato-2-propanones of the general formula IV, characterized by reacting a 3-chloro-3-(2-chloro-C 2-5 -alkyl)-2-propanone of the general formula V, wherein R is a straight-chain C 2-5 -alkyl group substituted with a chloro atom in the 2-position, with an inorganic thiocyanate, preferably selected from sodium thiocyanate, potassium thiocyanate and ammonium thiocyanate. The processes according to claim 5 and/or 6, wherein R is 2-chloroethyl. The processes according to claims 5 and/or 6 and/or 7, characterized by one more of the following features: (a) The hydrogenation of the compounds of formula II in step B is carried out in the presence of a metal catalyst in an inorganic solvent; (b) the hydrogenation of the compounds of formula II in step B is carried out in the presence of an acid binding agent, preferably in the presence of triethylamine; (c) the hydrogenation of the compounds of formula II in step B is carried out at or above atmospheric pressure, and preferably at a pressure of 0.7 MPa; (d) aliphatic alcohols, fatty acid esters formed with aliphatic alcohols, aromatic hydrocarbons and/or open-chain ethers are used as organic solvents in steps A1 and/or B; (e) the ring closure reaction of the compounds of the formula IV to the compounds of the formula II in step A1 is carried out in an anhydrous, water-immiscible solvent, which does not dissolve water,preferably in butyl acetate; (f) in step A2, aqueous phosphoric acid is used as aqueous mineral acid; (g) step A2 is carried out at a temperature ranging from 50 to 120°C; (h) the halogenation of the compounds of the formula III in step A2 is carried out with use of phosphoryl chloride, phosphorus pentachloride and/or phosphorus trichloride as halogenating agents; (i) the halogenation of the compound of the formula III in step A2 is carried out in a halogenated aromatic solvent; (j) the reaction of the compound of the formula V with the inorganic thiocyanate for preparing the compounds of the formula IV is carried out in the presence of a solvent such as aliphatic alcohols, aliphatic ketones, fatty acid esters formed with aliphatic alcohols, or water. The process according to one or more of claims 5, 7 and 8, characterized in that the compounds of the formula IV are prepered according to claim 6 without isolating the compounds of the formula IV. Pharmaceutical compositions, characterized by one or more of the compounds of the general formula I according to claim 1.

Inventors: BAN KAROLY, BONE ISTVAN DR, BUTTKAI ILDIKO, GARACZY SANDOR, GOENCZI CSABA DR, GYOERI PETER DR, GYUERE KAROLY, HEJA GERGELY DR, HUSZAR CSABA, KISS PAL DR, KOEVARI ARPAD, KORBONITS DESZO DR, LEDNICZKY LASZLO, MIHALOVICS GYOERGY, MOLNAR NEE BAKO ERZSEBET, MORASZ FERENC DR, NEMETH ATTILA, PALOSI ENDRE, SPERBER FERENC, SUETO MIHALY, SZABO NEE KARDOS ERZSEBET, SZALAY ERZSEBET, SZVOBODA NEE KANZEL IDA, BAN, KAROLY, BONE, ISTVAN, DR., BUTTKAI, ILDIKO, GARACZY, SANDOR, GOENCZI, CSABA, DR., GYOERI, PETER, DR., GYUERE, KAROLY, HEJA, GERGELY, DR., HUSZAR, CSABA, KISS, PAL, DR., KOEVARI, ARPAD, KORBONITS, DESZO, DR., LEDNICZKY, LASZLO, MIHALOVICS, GYOERGY, MOLNAR NEE BAKO, ERZSEBET, MORASZ, FERENC, DR., NEMETH, ATTILA, PALOSI, ENDRE, SPERBER, FERENC, SUETO, MIHALY, SZABO NEE KARDOS, ERZSEBET, SZALAY, ERZSEBET, SZVOBODA NEE KANZEL, IDA, Boné, Istvan, Dr., Gönczi, Csaba, Dr., Györi, Péter, Dr., Gyüre, Karoly, Héja, Gergely, Dr., Kövari, Arpad, Mihalovics, György, Molnar née Bako, Erzsébet, Németh, Attila, Süto, Mihaly, Szabo née Kardos, Erzsébet, SZALAY, Erzsébet, Szvoboda née Kanzel, Ida
Applicants: ASTRA AB, ASTRA AKTIEBOLAG
Application year: 1992
Main classification: C07D277
IPC codes: C07D277, A61K31, C07C331