Ethylenediamine-N,N'-diacetic acid-N'-cyanomethyl, salts thereof, and their preparation

Abstract: A novel intermediate useful in the synthesis of ethylenediaminetriacetic acid (ED3A) or its salts. A salt of N,N′-ethylenediaminediacetic acid (ED2AH₂) is condensed with formaldehyde to form a stable 5-membered ring intermediate. The addition of cyanide across this cyclic material forms ethylenediamine N,N′-diacetic acid-N′-cyanomethyl or salts thereof (mononitrile-diacid), which is a useful intermediate in the production of ED3A. The nitrile in aqueous solutions may be spontaneously cyclized to form 2-oxo-1,4-piperazinediacetic acid (3KP) or salts thereof. In the presence of excess base, salts of ED3A are formed in excellent yield and purity.

Description: Ethylenediaminetriacetic acid (ED3A) or its salts (such as ED3ANa 3 ) has applications in the field of chelating chemistry, and may be used as a starting material in the preparation of strong chelating polymers, oil soluble chelants, surfactants and others. Conventional routes for the synthesis of ethylenediaminetriacetic acid were achieved via its N-benzyl derivative, which was subsequently hydrolyzed in alkaline solutions to ED3ANa 3 , thus avoiding cyclization to its 2-oxo-1,4-piperazinediacetic acid (3KP) derivative. Syntheses attempted by both the alkaline condensation of chloroacetic acid with ethylenediamine, and the carboxymethylation of the diamine with formaldehyde and sodium cyanide resulted in complex mixtures requiring complex extraction techniques (e.g. almost exclusive solubility of 3KP in boiling dimethylformamide, Can. J. Chemistry 1970, 48(1), 163-175) to generate the desired product, and then in only relatively poor yield. In addition, conventional processes resulted in large quantities of by-product, such as ethylenediaminetetraacetic acid (ED4A). Where the by-products were especially objectionable, complicated blocking techniques were necessary in order to achieve a relatively pure solution. One example of the synthesis of ethylenediamine-N,N,N'-triacetic acid is shown in Chemical Abstracts 78, Vol. 71, page 451, no. 18369c, 1969. There it is disclosed that ethylenediamine reacts with ClH 2 CCO 2 H in a 1:3 molar ratio in basic solution at 10°C for 24 hours to form a mixture from which ethylenediamine-N,N,N'-triacetic acid can be separated by complexing the same with Co(III). The resulting cobalt complexes can be isolated through ion exchange. The instant invention is directed to a novel composition of matter that is useful as an intermediate in the synthesis of ethylenediaminetriacetic acid or its salts in high conversions and excellent yield. The problems of the prior art have been overcome by the instant invention, which provides a novel composition of matter useful as an intermediate in the synthesis of ethylenediaminetriacetic acid. Specifically, a mononitrile-diacid is formed by reacting a salt of N,N'-ethylenediaminediacetic acid (ED2AH 2 ) with formaldehyde to form a stable 5-membered ring intermediate. The addition of cyanide across this cyclic material forms ethylenediamine N,N'-diacetic acid-N'-cyanomethyl or salts thereof (the mononitrile-diacid). This nitrile in aqueous solutions may be spontaneously cyclized to form 3KP or salts thereof, which in the presence of excess base, forms salts of ED3A in excellent yield and purity. The present invention therefore provides a compound of the formula: wherein X and Y, which may be the same or different, each represent hydrogen or an alkali metal or alkaline earth metal. The invention further provides a process for the preparation of such compounds which process comprises: (a) the reaction of a compound of the formula wherein X is an alkali or alkaline earth metal cation, the sum of the values of a is 0 to 1, the sum of the values of b is 1 to 2 and the total of the values of a and b is 2, with formaldehyde; and (b) reacting the product of step (a) with a cyanide source. Suitable salts of ethylenediaminediacetic acid useful as the starting material in the instant invention include alkali and alkaline earth metal salts, in particular, the sodium and potassium salts. For purposes of illustration, the sodium salt will be used, although it should be understood that other salts may be employed without departing from the spirit and scope of the invention. One suitable reaction scheme for the synthesis of the mononitrile-diacid is the alkaline condensation of formaldehyde with N,N'-ethylenediamine disodium acetate to form a 5-membered ring structure, 1,3-bis(carboxymethyl)imidazolidine, and is illustrated as follows: the sum of the values of a is 0 to 1, the sum of the values of b is 1 to 2, and the total of the values of a and b is 2. The above reaction may be carried out in the presence of additional base. Suitable bases include alkali and alkaline earth metal hydroxides, preferably sodium and potassium hydroxide. Compound (I) is the bridged reaction product of EDDANa (1.0→2.0) and formaldehyde, which the present inventor has found to be a stable intermediate in the ED3A synthesis. Compound (I) is formed easily between 0° and 110°C. The reaction proceeds quickly and forms readily at pH's greater than about 7.0. Preferably the temperature employed is about 0 to 65°C, most preferably 15 to 65°C, although temperatures higher than 65°C are operable. Formaldehyde can be used in stoichiometric amounts, although it is preferred that a slight molar excess be used, preferably 0.5%-2.0%. Preferably the concentration of the formaldehyde is 55% or less in aqueous solution. Paraformaldehyde also can be used. The second step in the reaction scheme is illustrated below: Compound (II) is readily formed at temperatures between 0° and 110°C. The reaction should be conducted at temperatures at or below the boiling point of the solution. Preferably the reaction is carried out at temperatures from 0° to 65°C, most preferably 15° to 65°C to enhance the reaction rate. Suitable sources of cyanide include gaseous hydrogen cyanide, an aqueous solution of hydrogen cyanide, or alkali metal cyanide such as sodium cyanide or potassium cyanide, etc. The cyanide may be used in stoichiometric amounts, although slight molar excesses may be used, preferably 0.5% - 2.0%. Compound (II) is useful as an intermediate for the production of ED3A. Specifically, compound (II) may be hydrolyzed to the monoamide-diacid compound (III) (partially hydrolyzed mononitrile diacid), which spontaneously cyclizes to 3KP. Compound (IV) forms readily in the presence of a base such as alkali metal or alkaline earth metal hydroxides. Preferably the base is NaOH. Mole ratios of < 3.0M base : 1M ED2AH 2 but preferably < 2.0 M base : 1M ED2AH 2 are employed. Higher concentrations of base. (i.e. > 3.0 M base : M ED2AH 2 ) cause some disproportionation of the diacid mononitrile and some ED4A (ethylenediaminetetraacetic acid) is formed, especially at temperatures > 65°C. In particular, the concentration of ED4A is found to be in direct proportion to the amount of excess caustic employed, when high temperature reactions are conducted and high molar ratios of base are employed (> 2.0M base : 1M ED2AH 2 ), which may be attributed to the simultaneous hydrolysis of 3KP and disproportionation of the mononitrile-diacid. When the mole ratio of base to ED2A is < 2.0, higher temperatures may be used. Also, in Step III ammonia is eliminated between an amide group and an imino group on the same molecule. However, at lower temperatures (< 65°C) higher amounts of base may be employed (> 2.0M) and hydrolysis of compound (II) can proceed directly to ED3A without cyclization. The 3KPNa 2 is then hydrolyzed by at least the addition of 1 equivalent of caustic, preferably a 1 molar excess of caustic. This amounts to approximately 5% weight excess (free) caustic in solution on a 40% ED3ANa 3 solution. The solution is boiled under atmospheric pressure to the desired concentration. Preferably the reaction is carried out by raising the temperature from the temperature in the formation of compound (IV) reaction to the boil over a period from 30 minutes to 6 hours. The resulting solutions typically give approximately 35-40% ED3ANa 3 ; with approximately 2% 3KPNa 2 remaining as an unopened ringed structure. This corresponds to about a 94% conversion to ED3ANa 3 , with the remaining 6% of mass existing as 3KPNa 2 . Acidification of this mass to pH's < 6.0 to produce ED3AH 3 is not possible, as cyclization to 3KPH 2 will eventually occur. The foregoing synthetic scheme results in conversions to ED3ANa 3 in excess of 90%, with the residual proportion being 3KPNa 2 to give a total mass balance of virtually 100%. The reactions are tolerant to a wide pH range. The following Example illustrates the invention: EXAMPLE The following procedure to obtain ED2AH 2 was for experimental purposes only. Far less elaborate schemes for the production of ED2AH 2 are possible. Any schemes known in the art can be employed for the production of ED2AH 2 and its salts, and the instant invention is not to be limited by any particular scheme. In the following examples, all batches were synthesis from EDDAH 2 (98.20%) obtained by acidification of EDDANa 2 to a pH of 5.50 with nitric acid, while maintaining the temperature of the solution < 10°C. The resultant slurry was filtered by means of a Buchner funnel with the vacuum provided by a water aspirator. The filter cake was washed with approximately 7 liters of iced H 2 O. To enhance drying, the cake was then washed with approximately 1 liter of MeOH. The crystals were then placed on 1 inch deep stainless steel trays, dried in a Stokes vacuum dryer, model 338F at 40°C. under a vacuum of 4 mm Hg, for 12 hours. Approximately 2 Kg of a white crystalline powder was recovered. Analysis of this powder showed it to be 98.2% ED2AH 2 . All batches were synthesized on a 0.5 liter scale. 88 g of ED2AH 2 were charged to a 500 ml conical flask and diluted with 180 mls of H 2 O. 50% caustic was used to obtain the sodium salt in the ratio required. This solution was stirred for 30 minutes, and then charged to a 1 liter 5-necked round bottom flask. The conical flask was then washed with 20 mls. of H 2 O, and the washings transferred to the round bottom flask. The round bottom flask was equipped with a magnetic stirring bar, a condenser (ethylene glycol/H 2 O @ 0°C.), A 0-250°C mercury thermometer, and a J-type thermocouple that provided a signal to a Love proportional controller, which maintained the temperature at the desired level were employed. A Glass-Col heating mantle controlled by the Love controller via a Powerstat variable autotransformer was used to heat the contents of the flask. 37% CH 2 O and 100% HCN were pumped at approximately 1 g/minute and 0.50g/minute, respectively, by an FMI micro metering pump at a setting of 0.5, via 1/8" Teflon tubing to the flask. A 125 ml addition funnel equipped with a Teflon metering valve, and a condenser with the same coolant as described above, was used as the reservoir for the reactants to be pumped. Table 1 shows the results for the experiments conducted up to the spontaneous cyclization of monoamide-diacid after it has been hydrolyzed. The mononitrile-diacid was not isolated; however, it was identified by HPLC as being the precursor to 3KP. 3KP was more easily quantified by HPLC, and it is that compound which is quantitatively shown in Table 1. Table 2 shows results for ED3A produced for 9 conditions using the compound of the instant invention. The data demonstrate that both mass balances and conversions to product are excellent. ED3A was measured by copper(II) salt titration, and 3KP was measured by high pressure liquid chromatography (HPLC). The final column in the Table 1 shows the mass balances for stage 3 (the formation of 3KP) of the reaction. The 9th column in Table 2 shows the percent conversion to product based on recyclization. Recyclization was achieved by acidifying a sample of the reaction mass with HCl to a pH of 2.0. These samples were then allowed to stand in an oven at 40°C overnight and then on a bench at room temperature for 2 days prior to analysis. This technique was employed to verify the titration results, ensuring that all product was recyclized to 3KPH 2 . Mass balances are not as good as those that were titrated, and this may be attributed to HPLC error and dilution error, etc. It will be understood that in this specification including the accompanying claims formulae are drawn on the basis of a monovalent cation represented by X or Y. Alkaline earth metals are divalent and the formulae and quantities of divalent cation should be construed accordingly.

Claims: A compound of the formula: wherein X and Y, which may be the same or different, each represent hydrogen or an alkali metal or alkaline earth metal. A process for the preparation of a compound of the formula depicted in claim 1 which comprises (a) the reaction of a compound of the formula wherein X is an alkali or alkaline earth metal cation, the sum of the values of a is 0 to 1, the sum of the values of b is 1 to 2 and the total of the values of a and b is 2, with formaldehyde; and (b) reacting the product of step (a) with a cyanide source. A process according to claim 2, wherein the reaction of formaldehyde and ethylenediamine dialkali metal acetate is conducted at a temperature from 0° to 65°C. A process according to claim 2 or 3, wherein the reaction of formaldehyde and ethylenediamine dialkali metal acetate is conducted at a temperature from 15° to 65°C. A process according to any one of claims 2-4, wherein the reaction of step (b) is conducted at a temperature from 0° to 65°C. A process according to any one of claims 2-5, wherein the reaction of step (b) is conducted at a temperature from 15° to 65°C. A process according to any one of claims 2-6, wherein the formaldehyde is used in a slight molar excess. A process according to any one of claims 2-7, wherein the cyanide source is used in a slight molar excess. A process according to any one of claims 2-8, wherein the cyanide source is hydrogen cyanide or an alkali metal cyanide.

Inventors: PARKER BRIAN A, PARKER, BRIAN A.
Applicants: HAMPSHIRE CHEMICAL CORP, HAMPSHIRE CHEMICAL CORP.
Application year: 1992
Main classification: C07C255
IPC codes: C07C255, C11D3, C07C253