STEREOSELECTIVE PREPARATION OF SUBSTITUTED PIPERIDINES

Abstract: Novel processes are disclosed for the stereoselective preparation of substituted piperidine derivatives of formulae (IV) and (I) wherein R<1> and R<2> are defined as below.

Description: STEREOSELECTIVE PREPARATION OF SUBSTITUTED PIPERIDINES Background of the Invention This invention relates to novel processes for th stereoselective preparation of substituted piperidin derivatives. The substituted piperidines and related compounds tha can be prepared by the processes of this invention ar substance P receptor antagonists and are therefore useful i treating diseases mediated by an excess of substance P. Substance P is a naturally occurring undecapeptid belonging to the tachykinin family of peptides, the latte being named for their prompt stimulatory action on smoot muscle tissue. More specifically, substance P is a phar¬ macologically-active neuropeptide that is produced i mammals (having originally been isolated from gut) an possesses a characteristic amino acid sequence that is illustrated by D.F. Veber et al. in U.S. Patent No. 4,680,283. The wide involvement of substance P and other tachykinins in the pathophysiology of numerous diseases has been amply demonstrated in the art. For instance, substance P has been shown to be involved in the transmission of pain or migraine (see B.E.B. Sandberg et al., Journal of Medicinal Chemistry. Vol. 25, p. 1009 (1982)), as well as in central nervous system disorders such as anxiety and schizophrenia, in respiratory and inflammatory diseases such as asthma and rheumatoid arthritis, respectively, in rheumatic diseases such as fibrositis, and in gastrointestinal disorders and diseases of the GI tract, such as ulcerative colitis and Crohn's disease, etc. (see D. Regoli in "Trends in Cluster Headache," edited by F. Sicuteri et al. , Elsevier Scientific Publishers, Amsterdam, 1987, pp. 85-95). Several of the substituted piperidines and related compounds that can be prepared by the methods of this invention are claimed in PCT Patent Application PCT/US 90/00116, filed January 4, 1990, United States Patent Application Serial No. 07/717,943, filed June 20, 1991 an United States Patent Application Serial No. 07/724,268 entitled π 3-Aminopiperi ine Derivatives and Related Nitroge Containing Hetercycles" and filed July 1, 1991, all of whic are assigned in common with the present application. Othe methods for preparing such compounds referred to in th United States Patent Application entitled "Preparation o Substituted Piperidines", which was filed in November 27 1991 and is assigned in common with the present application Summary of the Invention The present invention relates to a process fo preparing a compound of the formula wherein R 1 is aryl selected from indanyl, phenyl an naphthyl; heteroaryl selected from thienyl, furyl, pyridy and quinolyl; and cycloalkyl having 3 to 7 carbon atoms wherein one of said carbon atoms may optionally be replace by nitrogen, oxygen or sulfur; wherein each of said aryl an heteroaryl groups may optionally be substituted with one o more substituents, and said (C 3 -C 7 ) cycloalkyl may optionall be substituted with one or two substituents, sai substituents being independently selected from chloro, fluoro, bromo, iodo, nitro, alkyl optionall substituted from one to three fluoro groups, (C J -C JO ) alkox optionally substituted with from one to three fluoro groups, 0 amino, (C^C^alkyl-S-, (C ! -C 10 )alkyl-S II-, (C^C j oJal yl-SO j -, phenyl, phenoxy, (C 1 -C 10 )alkyl-SO 2 NH-(C 1 C 10 )alkyl-, (C ι -C 10 )alkylamino-di(C 1 -C 10 )alkyl-, cyano, hydroxy, cycloalkoxy having 3 to 7 carbon atoms, (C j -C 6 )alk lamino, (Cj-Cg)dialkylamino, HCNH- and (Cj-C, 0 )alkyl-C-NH-, wherein the nitrogen atoms o said amino and (Cj-Cs) alkylamino groups may optionally b protected with an appropriate protecting group; and R 2 i thienyl, benzhydryl, naphthyl or phenyl optionall substituted with from one to three substituent independently selected from chloro, bromo, fluoro, iodo, cycloalkoxy having 3 to 7 carbon atoms, alky optionally substituted with from one to three fluoro group and (Ci-C, 0 ) alkoxy optionally substituted with from one t three fluoro groups, comprising reacting a compound of th formula wherein R ** is defined as above, with either (a) a compound o O the formula R'CX, wherein R 1 is defined as above and X is leaving group (e.g., chloro, bromo, iodo or i idazole) , followed by treatment of the resulting amide with a reducin agent, (b) a compound of the formula R'CHO, wherein R 1 i defined as above, in the presence of a reducing agent, o (c) a compound of the formula R'CI^X, wherein R 1 is defined a above and X is a leaving group (e.g., chloro, bromo, iodo, mesylate or tosylate) . As used herein, the term "halo" refers to chloro, bromo, fluoro or iodo. The compounds of formula I have chiral centers an therefore exist in different enantiomeric forms. Formula I, as depicted above, includes all optical isomers of suc compounds, and mixtures thereof. The present invention also relates to a process fo preparing a compound of the formula I, as depicted above, wherein R 1 and R 2 are defined as above, comprising reactin a compound of the formula IV, as depicted above, wherein R is defined as above, with a compound, of the formula R^HO, wherein R 1 is defined above, in the presence of a dryin agent or using an apparatus designed to remov azeotropically the water generated, to produce an i ine o the formula wherein R 1 and R 2 are defined as above, and then reacting the imine with a reducing agent to form a compound of the formula I, as depicted above, wherein R 1 and R 2 are defined as above. The present invention also relates to a process for preparing a compound of the formula I, as depicted above, wherein R 1 and R 2 are defined as above, comprising reducing a compound of the formula wherein R 2 is defined as above, to produce a compound of the formula IV, as depicted above, wherein R 2 is defined as above, and then converting the compound of formula IV so formed to a compound of the formula I using one of the procedures described above. This invention also relates to a process for preparing a compound of the formula I, as depicted above, wherein R 1 and R 2 are defined as above, comprising reacting a compound of the formula with hydrogen in the presence of a metal containing catalyst to form a compound of the formula IV, as depicted above, wherein R 2 is defined as above, and then converting the compound of formula IV so formed to a compound of the formula I using one of the procedures described above. Detailed Description of the Invention The processes and products of the present invention are illustrated in the following reaction scheme. Except where otherwise indicated, in the reaction scheme and discussion that follow, formulas I, II, III and IV, and substituents R 1 , R 2 and X are defined as above. ( I ) The reaction of a compound of the formula IV with compound of the formula R^HO to produce a compound of th formula I is typically carried out in the presence of reducing agent such as sodium cyanoborohydride, sodiu triacetoxyborohydride, sodium borohydride, hydrogen and metal catalyst, zinc and hydrochloric acid, or formic aci at a temperature from about -60°C to about 50°C. Suitabl reaction inert solvents for this reaction include lowe alcohols (e.g., methanol, ethanol and isopropanol), aceti acid and tetrahydrofuran (THF) . Preferably, the solvent i acetic acid, the temperature is about 25°C, and the reducin agent is sodium triacetoxyborohydride. This reactio proceeds to give material in which the addition of the CH 2 R sidechain occurs selectively at the 3-amino group, and th isomer of formula I is the only product isolated. Alternatively, the reaction of a compound of th formula IV with a compound of the formula R'CHO may b carried out in the presence of a drying agent or using a apparatus designed to remove azeotropically the wate generated, to produce an imine of the formula which is then reacted with a reducing agent as describe above, preferably with sodium triacetoxyborohydride at abou room temperature. The preparation of the imine is generall carried out in a reaction inert solvent such as benzene, xylene or toluene, preferably toluene, at a temperature fro about 25°C to about 110°C, preferably at about the reflu temperature of the solvent. Suitable drying agents/solven systems include titanium tetrachloride/dichloromethan titanium isopropoxide/dichloromethane and molecula sieves/THF. Titanium tetrachloride/dichloromethane i preferred. The reaction of a compound of the formula IV with compound of the formula R'CH-jX is typically carried out in reaction inert solvent such as dichloromethane or THF, preferably dichloromethane, at a temperature from about 0° to about 60°C, preferably at about 25°C. The reaction of a compound of the formula IV with a 0 II compound of the formula R*CX is typically carried out in a inert solvent such as tetrahydrofuran (THF) o dichloromethane at a temperature from about -20°C to abou 60 Q C, preferably in dichloromethane at about 0°C. Reductio of the resulting amide is accomplished by treatment with reducing agent such as borane dimethylsulfide complex lithium aluminum hydride or diisobutylaluminum hydride in a inert solvent such as ethyl ether or THF. The reactio temperature may range from about 0°C to about the reflu temperature of the solvent. Preferably, the reduction i accomplished using borane dimethylsulfide complex in THF a about 60°C. Reduction of the pyridine of formula II to form th corresponding piperidine of formula IV is generall accomplished using either sodium in alcohol, lithiu aluminum hydride/aluminum trichloride, electrolyti reduction or hydrogen in the presence of a metal containin catalyst. The reduction with sodium is generally conducte in a boiling alcohol, preferably butanol, at a temperatur from about 20°C to about the reflux temperature of th solvent, preferably at about 120°C. The reduction wit lithium aluminum hydride/aluminum trichloride is usuall carried out in ether, THF or dimethoxyethane, preferabl ether, at a temperature from about 25°C to about 100°C, preferably at about room temperature. The electrolyti reduction is conducted, preferably, at room temperature, but temperatures from about 10°C to about 60°C are also suitable. Hydrogenation in the presence of a metal containing catalyst is the preferred method of reduction. Suitable hydrogenation catalysts include palladium, platinum, nickel, platinum oxide and rhodium. The preferred catalyst for hydrogenation is platinum on carbon. The reaction temperature may range from about 10°C to about 50°C, with about 25°C being preferred. The hydrogenation is generally carried out at a pressure from about 1.5 to about 4 atmospheres, preferably at about 3.0 atmospheres, in a suitable inert solvent such as acetic acid or a lower alcohol, preferably methanol, with about a stoichiometric quantity of hydrogen chloride present. When the reduction is carried out via hydrogenation in the presence of a metal containing catalyst, material of the cis configuration is isolated exclusively and the pyridine ring is reduced selectively as opposed to the 2-phenyl moiety. The preparation of compounds of the formula IV from the corresponding compounds of the formula III is accomplished, as indicated above, by treating the compounds of formula III with hydrogen in the presence of a metal containing catalyst such as platinum or palladium. Generally, this reaction is conducted in a reaction inert solvent such as acetic acid or a lower alcohol, at a temperature from about 0°C to about 50°C. Alternatively, the compounds of formula III may be treated with a dissolving metal such as lithium or sodium in ammonia at a temperature from about -30°C to about -78°C, or with a formate salt in the presence of palladium or with cyclohexene in the presence of palladium. Preferably, the compounds of formula III are treated with hydrogen in the presence of palladium on carbon in a mixture of methanol/ethanol in water or methanol/ethanol containing hydrochloric acid at a temperature of about 25°C. When compounds of the formula III are treated with hydrogen in the presence of a metal containing catalyst, the only products isolated are the desired compounds of the formula IV. No products derived from cleavage of the alternative benzylic position of the piperidine ring (i.e., the bond between the nitrogen at position 1 and the carbon at position 2) are observed. The starting materials of the formulae 0 R'CX, R'CHO and R'CH 2 X that are used in the above reactions are either commercially available or obtainable by carrying out standard transformation well known to those skilled i the art upon commercially available materials. In each of the above reactions wherein one piperidin derivative is converted to another piperidine derivativ (i.e., Ill → IV and IV → I), the absolute stereochemistr about the carbons at positions 2 and 3 of the piperidin ring is preserved. Therefore, for each such reaction, racemic mixture or a pure enantiomer may be obtained b using the appropriate starting material having the sam stereochemistry. The resolution of a racemic mixture of a compound o the formula I to prepare the (+) enantiomer of such compoun is generally carried out using methanol, ethanol, o isopropanol, preferably isopropanol, as the organic reactio inert solvent. Preferably, the resolution is carried out b combining a racemic mixture of a compound of the formula and (R)-(-)-mandelic acid in isopropanol, and stirring th mixture to form an optically enriched mandelic acid sal precipitate. The optically enriched precipitate is the recrystallized twice from isopropanol, after which th recrystallized precipitate is converted to the free base o the optically pure compound of formula I by partitioning i between dichloromethane and an aqueous base such as sodiu hydroxide, sodium bicarbonate or potassium bicarbonate preferably sodium hydroxide, or by stirring an alcoholi solution of the salt with a basic ion exchange resin. Th free base, which is dissolved in the methylene chloride, ca then be converted to the corresponding hydrochloric aci salt. Isolation of the mandelate may be conducted a temperatures from about 0°C to about 40°C. About 25°C i preferred. In each of the reactions discussed or illustrate above, pressure is not critical unless otherwise indicated. Pressures from about 0.5 atmospheres to about 5. atmospheres are generally acceptable, and ambient pressure, i.e., about one atmosphere, is preferred as a matter o convenience. The compounds of Formula I and their pharmaceutically acceptable salts exhibit substance P receptor antagonist activity and therefore are of value in the treatment and prevention of a wide variety of clinical conditions the treatment or prevention of which are effected or facilitated by a decrease in substance P mediated neurotransmission. Such conditions include inflammatory diseases (e.g., arthritis, psoriasis, asthma and inflammatory bowel disease) , anxiety, depression or dysthymic disorders, colitis, psychosis, pain, allergies such as eczema and rhinitis, chronic obstructive airways disease, hypersensitivity disorders such as poison ivy, vasospastic diseases such as angina, migraine and Reynaud's disease, fibrosing and collagen diseases such as scleroderma and eosinophilic fascioliasis, reflex sympathetic dystrophy such as shoulder/hand syndrome, addiction disorders such as alcoholism, stress related somatic disorders, peripheral neuropathy, neuralgia, neuropathological disorders such as Alzheimer's disease, AIDS related dementia, diabetic neuropathy and multiple sclerosis, disorders related to immune enhancement or suppression such as systemic lupus erythematosus, and rheumatic diseases such as fibrositis. Hence, these compounds are readily adapted to therapeutic use as substance P receptor antagonists for the control and/or treatment of any of the aforesaid clinical conditions in mammals, including humans. The compounds of the formula I and the pharmaceutically acceptable salts thereof can be administered via either the oral, parenteral or topical routes. In general, these compounds are most desirably administered in dosages ranging from about 5.0 mg up to about 1500 mg per day, although variations will necessarily occur depending upon the weight and condition of the subject being treated and the particular route of administration chosen. However, a dosage level that is in the range of about 0.07 mg to about 21 mg per kg of body weight per day is most desirably employed. The following examples illustrate the methods a compounds of the present invention but do not limit it scope. As indicated above, the starting materials used in th reaction of this invention are either commecially availabl or obtainable by carrying out standard transformation wel known to those skilled in the art upon commerciall available materials. Table 1 below indicates how th aldehydes of the formula R^HO used in the examples wer obtained. The standard transformations used to prepar these aldehydes are identified by one or more lower cas letters in the column labelled "Reaction Sequence" in Tabl 1. The letters used to identify such transformations ar explained in the key following Table 1. Table 1 (Continued) Preparation of R'CHO Reaction* R 1 Starting Material Sequence 5-s-buytI-2-methoxyphenyl 4-s-butylphenol e, a 5-fluoro-2-methoxyρheny 4-fluoro-methoxybenzene 2-acetamidophenyl 2-aminobenzaldehyde 2-methoxyphenyI commercial 5-isopropyl-2-methoxyphenyl 4-isopropyl-methoxybenzene a 5-n-propyl-2-methoxyphenyl 4-n-propylphenol e, a 4,5-dimethyl-2-methoxyphenyl 3 ,4-dimethylphenol e, a 5-heptyl-2-methoxyphenyl 4-heptylphenol e, a 2-heptyloxy-5-methoxyphenyl 4-heptyloxyphenol e, a 5-heptyIoxy-2-methoxyphenyI 4-heptyloxyphenol e, a 2-(2,2,2-trϊfluoroethoxy)phenyl 2-chlorobenzonitrile g. h quinolin-8-yl 8-methylquinoline 5-hydroxy-2-methoxyphenyl 4-methoxyphenol 2-methoxy-5-phenyIphenyl 4-phenylphenol e, a 4-amino-5-chIoro-2-methoxyphenyl 4-amino-5-chloro-2-methoxybenzoic acid 2-hydroxy-5-trifluoromethoxyphenyl 2-methoxy-5-trifluoromethoxybenz- aldehyde 5-t-butyl-2-hydroxyphenyI 4-t-butylphenol 3 -trifluoromethoxyphenyl commercial 5-chloro-2-(2,2,2- 2,6-dichlorobenzonitrile g. h trifluoroethoxy)phenyl 5-carbomethoxy-2-methoxyphenyl 5-carbomethoxy-2-hydroxybenzalde- hyde 5-t-butyl-2-trifluoromethoxyphenyI trifluoromethoxybenzene 1, 5-n-butyl-2-methoxyphenyl 4-n-butylphenol e, a *Reaqents for Preparation of R'CHO From Standard Routes a) Cl 2 CHOCH 3 , TiCl 4 b) dimethylsulf ate c) Br 2 /HOAc d) cyclopentyl bromide e) methyl iodide f) acetyl chloride g) NaOCH 2 CF 3 h) Raney nickel, HC0 2 H i) Se0 2 j) 1) carbonyldiimdazole, 2) N,0-dimethylhydroxylamine, 3) diisolbutylaluminum hydride k) BBr 3 1) t-butyl chloride/AlCl 3 m) Cl 2 CHOCH 3 /AlCl 3 n) ethyl iodide p) C1F,CH q) isopropyl bromide r) H 2 , Pd/C, HCHO s) 1) methanol/HCl, 2) methylsulfonyl chloride, 3) methyl iodide, 4) diisobutylauminum hydride, 5) Mn0 2 t) borane methylsulfide complex u) monoperoxyphthalic acid, magnesium salt hexahydrate v) H,-Pd/BaS0 4 EXAMPLE 1 (+) - (2S,3S)-3-Amino-2-phenylpiperidine In a bottle were placed 9 g of 10 % palladium-carbon, 180 ml of methanol, 275 ml of ethanol, 6.5 ml o concentrated hydrochloric acid and 9 g of the hydrochlorid saltof (2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine. The mixture was shaken under hydrogen (40 p.s.i.) overnight, 9 g of additional catalyst were added to the system and th mixture was shaken under hydrogen for 1 day. The mixtur was diluted with water (250 mL) , filtered throug diatomaceous earth (Celite (trademark) ) and the Celite wa rinsed well with water. The filtrate was concentrated to volume of ca. 600-700 mL, made basic with concentrate aqueous sodium hydroxide and extracted with chloroform, an the chloroform extracts were dried (sodium sulfate) an concentrated to obtain 4.4 g of the title compound as colorless oil. [o] D (HCl salt) = + 62.8° (c = 0.46, methanol (CH 3 OH) ) . Η NMR (CDC1 3 ) δ 1.68 (m, 4H) , 2.72 (m, IH) , 2.94 (broa s, IH) , 3.16 (m, IH) , 3.80 (d, IH, J=3) , 7.24 ( , 5H) . HRMS Calc'd for C n H 16 N 2 : 176.1310. Found: 176.1309. Calc'd for C n H 16 N 2 « 2HCl«l/3H 2 0: C, 51.78; H, 7.36; N, 10.98. Found: C, 51.46; H, 7.27; N, 10.77. EXAMPLE 2 ( + ) - f2S .3S) -3- (2.5-Dimethoxybenzylamino. -2 - phenylpiperidine Under a nitrogen atmosphere in a round-bottom flas were placed 600 mg (3.4 mmol) of (+)-(2S,3S)-3-amino-2 phenylpiperidine, 8 ml of acetic acid and 622 mg (3.7 mmol) of 2,5-dimethoxybenzaldehyde, and the mixture was stirre for 30 minutes. To the system were added 1.58 g (7.5 mmol) of sodium triacetoxyborohydride, and the mixture was stirre at room temperature overnight. The mixture wa concentrated, basified with 1 M aqueous sodium hydroxide an extracted with methylene chloride. The methylene chlorid extracts were washed with water and extracted with 1 aqueous hydrochloric acid. The hydrochloric acid extract were basified with 1 M aqueous sodium hydroxide an extracted with methylene chloride. The methylene chlorid extracts were dried (sodium sulfate) and concentrated t obtain 528 mg of colorless oil. The oil was dissolved i methylene chloride, and ether saturated with hydroge chloride was added to the solution. The resulting whit solid was collected by filtration and stirred in isopropano at 60°C for 2 hours. Filtration afforded 414 mg of th title compound as its hydrochloride. Additional materia (400 mg) was obtained by extracting the initial basic laye with additional methylene chloride, drying (sodium sulfate and concentration. [α] D (HCl salt) - + 60.5° (c=0.58, CH 3 OH) *H NMR (CDC1 3 ) δ 1.38 (m, IH) , 1.58 (m, IH) 1.88 ( IH) , 2.13 (m, IH) , 2.78 ( , 2H) , 3.25 (m, IH) , 3.36 (d, IH J=18), 3.44 (s, 3H) , 3.62 (d, IH, J=18) , 3.72 (s, 3H) , 3.8 (d, IH, J=3), 6.62 (m, 3H) , 7.24 (m, 5H) . Mass spectrum: m/z 326(parent). Calc'd for C 20 H 26 N 2 O 2 »2HCl«0.25H 2 O: C, 59.48; H, 7.11; N 6.93. Found: C, 59.33; H, 6.91; N, 7.23. EXAMPLE 3 Cis-3-amino-2-phenylpiperidine In a bottle were placed 2.65 g (15.6 mmol) of 3-amino 2-phenylpyridine, 10.6 g of 5% platinum/carbon and 106 mL o 1.5 M HCl in methanol. The mixture was shaken under a atmosphere (ca. 40 p.s.i.) of hydrogen for 2.5 hours. Wate was added to the system, the mixture was filtered through pad of diatomaceous earth and the pad was rinsed with ca. 700 mL of water. The filtrate was made basic with soli sodium hydroxide and extracted with two portions of dichloromethane. The combined organic fractions were washed with water, dried (sodium sulfate) and concentrated with a rotary evaporator to obtain 2.4 g of the title compound as a yellow oil. Calc'd for C n Hι 6 N 2 O»0.25H,0: C, 73.08; H, 9.20; N, 15.89. Found : C, 72.80; H, 9.46; N, 15.84. The title compounds if Examples 4-23 and 25-81 were prepared from either (+)-(2S,3S)-3-amino-2-phenylpiperidine or the corresponding racemate by employing the appropriat aldehyde and using a procedure similar to that of Example 2. EXAMPLE 4 Cis-3- (4 , 5-difluoro-2-methoxybenzylamino) -2 phenylpiperidine - NMR (CDC1 3 ) S 1.30 (m, IH) , 1.62 (m, 2H) , 1.96 (m, IH) , 2.68 (m, 2H) , 3.18 (m, 2H) , 3.32 (s, 3H) , 3.44 (d, IH, J=14) , 3.82 (d, IH, J=3) , 6.38 (dd, IH, J=6,12) , 6.66 (dd, IH, J=8, 10) , 7.16 (m, 5H) . HRMS Calc'd for Cι 9 H 22 N 2 F 2 0: 332.1697. Found: 332.1698. Calc'd for C 19 H 22 N 2 OF 2 »2HCl»0.85H 2 O: C, 54.25; H, 6.15; N, 6.66. Found: C, 54.26; H, 5.84; N, 6.94. EXAMPLE 5 Cis-3-f2-chloro-4-fluorobenzylamino)-2-phenylpiperidin l E NMR (CDC1 3 ) <S 1.44 ( , IH) , 2.06 (m, IH) , 2.78 (m, 2H) , 3.24 (m, IH) , 3.40 (d, IH, J=12) , 3.58 (d, IH, J=12) , 3.88 (d, IH, J=3), 6.75 (m, IH) , 6.92 ( , 2H) , 7.26 (m, 5H) . HRMS Calc'd for Cι 8 H 20 N 2 35 ClF:318.1294. Found: 318.1280. EXAMPLE 6 Cis-3- (2-ethoxybenzylamino) -2-phenylpiperidine >H NMR (CDC1 3 ) δ 1.10 (t, 3H, J=5) , 1.40 (m, IH) , 1.62 (m, IH) , 1.90 (m, IH) , 2.14 (m, IH) , 2.80 (m, 2H) , 3.27 (m, IH) , 3.38 (d, IH, J=15) , 3.69 (m, 3H) , 3.86 (d, IH, J=2) , 6.64 (d, IH, J=8) , 6.78 (t, IH, J=6) , 6.94 (d, IH, J=6) , 7.12 (t, IH, J=8) , 7.24 (m, 5H) . HRMS Calc'd for C 20 H 26 N 2 O:310.2041. Found: 310.2045. EXAMPLE 7 Cis-3- ( 2-hydroxybenzylamino) -2-phenylpiper idine ■ H NMR (CDCI 3 ) δ 1.62 (m, 3H) , 2.10 (m, IH) , 2.79 (m, IH) , 2.92 (m, IH) , 3.20 (m, IH) , 3.48 (s, 2H) , 3.82 (d, IH, J=2) , 6.72 (m, 3H) , 7.08 (m, IH) , 7.36 (m, 5H) . HRMS Calc'd for C 18 H 22 N 2 0: 282.1732. Found: 282.1724. Calc'd for C, 8 H 22 N 2 0»2HC1«2H 2 0: C, 55.26, H, 7.20; N, 7.16. Found: C, 55.13; H, 7.12; N, 6.84. EXAMPLE 8 Cis-3- ( 3 ,5-difluoro-2-methoχybenzγlamino) -2 phenylpiperidine -K NMR (CDC1 3 ) δ 1.45 (m, IH) , 1.64 (m, IH) , 1.86 (m IH), 2.08 (m, IH) , 2.80 (m, 2H) , 3.24 (m, IH) , 3.44 (d, IH J=15) , 3.54 (d, IH, J=15) , 3.68 (s, 3H) , 3.90 (d, IH, J=3 ) 6.57 (dd, IH, J = 8, 9), 6.69 (dd, IH, J=9 , 12) , 7.28 (m 5H) . HRMS Calc'd for C 19 H 22 N 2 OF 2 : 332.1698. Found: 332.1700 Calc'd for C 19 H 22 N 2 OF 2 * »2HCl:C, 56.30; H, 5.97; N, 6.92. Found C, 56.17; H, 5.84; N, 6.59. EXAMPLE 9 Cis-3-(2-chloro-6-fluorobenzylamino)-2-phenylpiperidin 'H NMR (CDC1 3 ) δ 1.40 (m, IH) , 1.66 ( , IH) , 1.90 (m IH) , 2.15 (m, IH) , 2.78 (m, 2H) , 3.26 (m, IH) , 3.68 (d, 2H J=18), 3.72 (d, IH, J=18) , 6.82 ( , IH) , 7.04 (m, 2H) , 7.2 (m, 5H) . HRMS Calc'd for C 18 H 20 N 2 ClF«2HCl*2/3H 2 O: C, 53.56; H 5.83; N, 6.95. Found: C, 53.63; H, 5.53; N, 6.83. EXAMPLE 10 ( 2S , 3S) -3-(5-chloro-2 -methoxybenzy 1 amino ) -2 phenylpiperidine Mp 275-277 °C (HCl salt) . ~ U NMR (CDC1 3 ) δ 1.40 (m, IH) , 1.60 (m, IH) , 1.90 ( IH) , 2.08 (m, IH) , 2.79 (m, 2H) , 3.26 (m, IH) , 3.36 (d, IH, J=15) , 3.45 (s, 3H) , 3.60 (d, IH, J=15) , 3.88 (d, IH, J=3), 6.56 (d, IH, J=8) , 6.92 (d, IH, J=3 ) , 7.06 (dd, IH, J=3 , 8), 7.28 (m, 5H) . Mass spectrum: m/z 330 (parent) . EXAMPLE 11 Cis-3- (5-chloro-2-methoxybenzylamino) - 2 phenylpiperidine -E NMR (CDC1 3 ) δ 1.37 (m, IH) , 1.56 (m, IH) , 1.86 ( , IH) , 2.06 (m, IH) , 2.76 (m, 2H) , 3.23 (m, IH) , 3.32 (d, IH, J=15) , 3.42 (s, 3H) , 3.58 (d, IH, J=15) , 3.85 (d, IH, J=3) , 6.54 (d, IH, J=8), 6.90 (d, IH, J=3), 7.04 (dd, IH, J=3 , 8), 7.24 (m, 5H) . EXAMPLE 12 Cis-3- (2.5-dimethoxybenzylamino) -2-phenylpiperidine M.p. 250-252°C (HCl salt). 'H NMR (CDC1 3 ) δ 1.28-1.40 (m, IH) , 1.48-1.92 (m, 2H) , 2.02-2.14 (m, IH) , 2.66-2.80 (m, 2H) , 3.14-3.24 (m, IH) , 3.32 (d, IH, J=18) , 3.38 (s, 3H) , 3.56 (d, IH, J=18) , 3.66 (s, 3H) , 3.83 (d, IH, J=3), 6.48-6.62 (m, 3H) , 7.10-7.26 (m, 5H) . HRMS Calc'd for C 20 H 26 N 2 0 2 : 326.1995. Found: 326.1959. Anal. Calc'd for C 20 H 26 N 2 O 2 »2HCl«0.3H 2 0:C, 59.34; H, 7.12; N, 6.92. Found: C, 59.33; H, 6.96; N, 6.76. EXAMPLE 13 Cis-3- (5-f luoro-2-methoxybenzylamino ) - 2 - phenylpiperidine M.p. 270-272°C (HCl salt) . HRMS Calc'd for C 19 H 23 FN 2 0: 314.1791. Found: 314.1766. Anal. Calc'd for C 19 H 23 FN 2 0»2HC1«0.5H 2 0:C, 57.58; H, 6.61; N, 7.07. Found: C, 57.35; H, 6.36; N, 7.03. Η NMR (CDC1 3 ) δ 1.30-1.42 (m, IH) , 1.48-2.12 (m, 3H) , 2.64-2.82 (m, 2H) , 3.12-3.26 (m, IH) , 3.32 (d, IH, J=12) , 3.42 (S, 3H) , 3.56 (d, IH, J=12), 3.84 (d, IH, J=3) , 6.53 (dd, IH, J=5, 10) , 6.64 (dd, IH, J=3 , 8) , 6.70-6.80 (m, IH) , 7.12-7.40 (m, 5H) . EXAMPLE 14 Cis-2-phenyl-3- f 2- (prop-2-yloxy) benzylamino] piperidine ■ B. NMR (CDC1 3 ) δ 1.00 (m, 6H) , 1.30 (m, IH) , 1.70 (m, 2H) , 2.10 (m, IH) , 2.72 (m, 2H) , 3.18 (m, IH) , 3.30 (m, IH) , 3.50 (m, IH) , 3.80 (br s, IH) , 4.06 (m, IH) , 6.66 (m, 2H) , 6.90 (m, IH) , 7.05 (m, IH) , 7.20 (m, 5H) . HRMS Calc'd for C 21 H 28 N 2 0: 324.2197. Found: 324.2180. Calc'd for C 2 ιH 28 N 2 0»2HCl«l.66H 2 0:C, 59.02; H, 7.85; N, 6.55. Found: C, 59.07; H, 7.77; N, 6.69. EXAMPLE 15 Cis-3- (3-fluoro-2-methoxybenzylamino) - 2 phenylpiperidine -B. NMR (CDC1 3 ) <S 1.40 (m, IH) , 1.60 (m, IH) , 1.86 (m IH), 2.08 ( , IH) , 2.80 (m, 2H) , 3.23 (m, IH) , 3.36 (m, IH) 3.58 (m, 4H) , 3.88 (m, IH) , 6.80 (m, 3H) , 7.26 ( , 5H) . HRMS Calc'd for C^H^F^O: 314.1794. Found: 314.1768. Calc'd for Cι 9 H 23 FN 2 0»2HCl»1.5H 2 0:C, 55.08; H, 6.80; N, 6.76. Found: C, 54.89; H, 6.48; N, 6.79. EXAMPLE 16 Cis-3- ( 5-chloro-3-f luoro-2-methoxybenzylamino) -2 phenylpiperidine X H NMR (CDC1 3 ) δ 1.42 (m, IH) , 1.54 (m, IH) , 1.80 (m, IH) , 2.06 (m, IH) , 2.78 (m, 2H) , 3.20 (m, IH) , 3.42 (d, IH, J=15) , 3.58 (d, IH, J=15) , 3.64 (s, 3H) , 3.86 (m, IH) , 6.6 (d, IH, J=9), 6.91 (d, IH, J=9) , 7.26 ( , 5H) . HRMS Calc'd for C 19 H 22 FN 2 OCl:348.1401. Found: 348.1406. EXAMPLE 17 Cis-3- f 3-chloro-5-f luoro-2-methoxybenzylamino) -2- pheny lp iper idine -E NMR (CDC1 3 ) δ 1.44 (m, IH) , 1.58 (m, IH) , 1.80 ( , IH) , 2.06 (m, IH) , 2.80 (m, 2H) , 3.22 (m, IH) , 3.42 (d, IH, J=18), 3.54 (d, IH, J=18) , 3.66 (s, 3H) , 3.88 (d, IH, J=2), 6.55 (d, IH, J=6), 6.92 (d, IH, J=9) , 7.26 (m, 5H) . HRMS Calc'd for Cι 9 H 22 ClFN 2 0: 348.1401. Found: 348.1411. Calc'd for C 19 H 22 C1FN 2 0-»2HC1 * »0.25H 2 0:C, 53.53; H, 5.79; N, 6.57. Found: C, 53.58; H, 5.60; N, 6.41. EXAMPLE 18 Cis-3- ( 3 , 5-dichloro-2-methoxybenzy 1 ami no ) -2 - phenylpiperidine -H NMR (CDC1 3 ) δ 1.44 (m, IH) , 1.56 (m, IH) , 1.82 (m, IH) , 2.08 (m, IH) , 2.80 (m, 2H) , 3.20 (m, IH) , 3.50 (m, 2H) , 3.64 (s, 3H) , 3.88 (m, IH) , 6.68 (s, IH) , 7.26 (m, 6H) . HRMS Calc'd for Cι 9 H 22 Cl 2 N 2 O:364.1105. Found: 364.1105. Calc'd for Cι 9 H 22 Cl 2 N 2 0«2HCl:C, 52.07; H, 5.52; N, 6.39. Found: C, 51.69; H, 5.50; N, 6.32. EXAMPLE 19 Cis-3-f4-Methoxybenzylamino) -2-phenylpiperidine M.p. 264-266°C (HCl salt) . -H NMR (CDC1 3 ) δ 1.28-1.40 (m, IH) , 1.44-1.88 (m, 2H) , 1.92-2.02 (m, IH) , 2.64-2.84 (m, 2H) , 3.10-3.22 (m, IH) , 3.19 (d, IH, J=12), 3.39 (d, IH, J=12) , 3.70 (s, 3H) , 3.8 (d, IH, J=3), 6.65 (d, 2H, J=8) , 6.83 (d, 2H, J=6) , 7.12 7.28 (m, 5H) . HRMS Calc'd for C 19 H 24 N 2 0: 296.1885. Found: 296.1871. Calc'd for C 19 H 24 N 2 0«2HC1«0.6H 2 0: C, 60.03; H, 7.21; N, 7.37. Found: 60.08; H, 7.11; N, 7.45. EXAMPLE 20 Cis-2-Phenyl-3- (thien-2-ylmethylamino) piperidine M.p. 250-252°C (HCl salt). Η NMR (CDC1 3 ) δ 1.30-1.40 (m, IH) , 1.46-1.52 (m, IH) , 1.68-1.86 (m, IH) , 1.92-2.00 (m, IH) , 2.64-2.78 (m, IH) , 2.84-2.92 (m, IH) , 3.12-3.22 (m, IH) , 3.44 (d, IH, J=12) , 3.54 (d, IH, J=12), 3.81 (d, IH, J=3) , 6.53 (d, IH, J=4), 6.72-6.80 (m, IH) , 7.02 (d, IH, J=6) , 7.12-7.30 (m, 5H) . HRMS Calc'd for C I6 H 20 N 2 S: 272.1373. Found: 272.1327. Calc'd for C 16 H 20 N 2 S»2HC1»1.1H 2 0: C, 52.62; H, 6.67; N, 7.67. Found: C, 52.64; H, 6.38; N, 7.65. EXAMPLE 21 Cis-3- (2-Methoxynapth-l-ylmethylamino) -2-phenylpjperidine M.p. 222-225°C (HCl salt). Η NMR (CDCI 3 ) δ 1.36-1.48 (m, IH) , 1.52-2.04 (m, 2H) , 2.18-2.32 (m, IH) , 2.68-2.82 (m, IH) , 2.90 (d, IH, J=3) , 3.18-3.28 (m, IH) , 3.64 (s, 3H) , 3.80 (d, IH, J=12) , 3.86 (d, IH, J=4), 4.07 (d, IH, J=12), 7.02-7.32 (m, 8H) , 7.57 (d, IH, J=8) , 7.60-7.70 (m, 2H) . HRMS Calc'd for C 23 H 26 N 2 0: 346.2041. Found: 346.2043. EXAMPLE 22 Cis-2-Phenyl-3-(thien-3-γlmethylamino)piperidine M.p. 264-267°C (HCL salt) . -H NMR (CDCI 3 ) s 1-30-1.40 (m, IH) , 1.46-1.64 (m, IH) , 1.70-1.88 (m, IH) , 1.92-2.02 (m, IH) , 2.68-2.78 (m, IH) , 2.80-2.88 (m, IH) , 3.14-3.22 (m, IH) , 3.31 (d, IH, J=12) , 3.48 (d, IH, J=12) , 3.84 (d, 1H, J=3), 6.65 (d, IH, J=6) 6.72 (d, IH, J=3), 7.04-7.10 (m, IH) , 7.14-7.28 (m, 5H) . HRMS Calc'd for C 16 H 20 N 2 S : 272.1342. Found: 272.1364 Calc'd for C 16 H 20 N 2 S<»2HC1"»0.6H 2 0:C, 53.96; H, 6.57; N, 7.87 Found: C, 53.97; H, 6.25; N, 7.77. EXAMPLE 23 Cis-3- (2 ,5-Difluorobenzylamino) -2-phenylpiperidine M.p. 274-276°C (HCL salt). *H NMR (CDC1 3 ) δ 1.28-1.40 (m, IH) , 1.44-1.62 (m, IH) 1.66-1.84 (m, IH) , 1.90-2.00 (m, IH) , 2.64-2.76 (m, 2H) 2.10-3.20 (m, IH) , 3.32 (d, IH, J=12), 3.44 (d, IH, J=12) 3.81 (d, IH, J=3) , 6.50-6.58 (m, IH) , 6.62-6.78 (m, 2H) 7.10-7.26 (m, 5H) . HRMS Calc'd for C lg H 20 F 2 N 2 :302.1590. Found: 302.1560 Calc'd for C lg H 20 F 2 N 2 «2HCl«0.2H 2 0:C, 57.06; H, 5.96; N, 7.39 Found: C, 56.94; H, 5.94; N, 7.37. EXAMPLE 24 (2S,3S)-3-Amino-2-phenylpiperidine In a bottle were placed 31 g of 10% palladium-carbon 50 L of water, 300 mL of methanol, 450 mL of ethanol, 20 of concentrated aqueous hydrochloric acid and 15 g (0.0 mole) of the hydrochloride salt of (2S,3S)-3-(2 methoxybenzyl)amino-2-phenylpiperdine. The mixture wa shaken under hydrogen (40 p.s.i.) for 1 day and filtere through a pad of diatomaceous earth. The pad was rinse with 2N aqueous hydrochloric acid (HCl) , water, ethanol an water and concentrated with a rotary evaporator. Water wa added to the residue and the mixture was made basic using 4 aqueous sodium hydroxide (NaOH) . The mixture was extracte with four portions of dichloromethane, and the extracts wer dried over magnesium sulfate (MgS0 4 ) and concentrated t obtain 2.23 g of the title compound. The aqueous fractio was concentrated to dryness and triturated with chloroform. Concentration of the chloroform solution afforded a additional 4.15 g of title compound. The product obtaine in this manner had spectral properties identical to those of the product of Example 1. EXAMPLE 25 Cis-3- (2 ,4-dimethoxγbenzyl) amino-2-phenylpiperidine -H NMR (CDC1 3 ) δ 1.38 (m, IH) , 1.65 (m, IH) , 1.9 (m, 2H) , 2.15 (m, IH) , 2.8 (m, 2H) , 3.25 (m, IH) , 3.35 (d, IH, J=15) , 3.4 (s, 3H) , 3.6 (d, IH, J=15) , 3.78 (s, 3H) , 3.85 (d, IH, J=3), 6.25 (d, IH, J=3), 6.35 (dd, IH, J=10, 3) , 6.85 (d, IH, J=10) , 7.30 (m, 5H) . Mass spectrum m/z 326 (parent) . Anal, calc'd for C 20 H 26 N 2 o 2 »2HCl:C, 60.14; H, 7.07, N, 7.02 Found: C, 59.66; H, 7.11; N, 6.83. EXAMPLE 26 Cis-3- (2.4 dichloro-6-methoxybenzyl) amino-2- phenylpiperidine M.p. 256-258°C (HCl salt) . -H NMR (CDC1 3 ) δ 1.4 (m, IH) , 1.62 (m, 3H) , 1.94 (m, IH) , 2.2 (m, IH) , 2.68 (m, IH) , 2.76 ( , IH) , 3.2 (m, IH) , 3.38 (s, 3H) , 3.4 (d, IH, J=10) , 3.64 (d, IH, J=10) , 3.84 (m, IH) , 6.48 (d, IH, J=3), 6.84 (d, IH, J=3) , 7.2 (m, 5H) . Mass Spectrum m/z 364 (parent) . Anal, calc'd for C, 9 H 22 C1 2 N 2 0«2HC1: C, 52.07; H, 5.52; N, 6.39. Found: C, 51.81; H, 5.65; N, 6.17. EXAMPLE 27 Cis-3- < 2 ,6-dichloro-4-methoxybenzyl) amino-2- phenylpiperidine M.p. 230-240°C (HCl salt) . 'H NMR (CDC1 3 ) δ 1.4 (m, IH) , 1.6 (m, 3H) , 1.92 (m, IH) , 2.16 (m, IH) , 2.76 (m, 2H) , 3.2 (m, IH) , 3.58 (d, IH, J=12) , 3.70 (Ξ, 3H) , 3.74 (d, IH, J=12) , 3.86 (d, IH, J=3) , 6.66 (m, 2H) , 7.2 (m, 5H) . Mass Spectrum m/z 364 (parent) . Anal, calc'd for Cι 9 H 22 Cl 2 N0 2 »2HCl: C, 52.07; H, 5.52; N, 6.39. Found: C, 52.18; H, 5.46; N, 6.24. EXAMPLE 28 Cis-3- (3 , 4-dichloro-2-methoxybenzyl) amino-2-phenylpiperidine M.p. 246-248° (HCl salt) . -H NMR (CDC1 3 ) δ 1.4 (m, IH) , 1.65 (s, 2H) , 1.9 (m, IH) , 2.05 (m, 2H) , 2.8 (m, 2H) , 3.25 (m, IH) , 3.45 (d, IH, J=15) , 3.6 (d, IH, J=15) , 3.9 (m, 4H) , 6.65 (d, IH, J=10) , 6.90 ( IH, J=10) , 7.3 (m, 5H) . HRMS Calc'd for C 19 H 22 C1 2 N 2 0«2HC1: C, 52.07; H, 5.52; 6.39. Found: C, 51.58; H, 5.46; N, 6.26. EXAMPLE 29 Cis-3- (2 , 3-dimethoxybenzyl) amino-2 -phenylpiperidine M.p. 238-240°C (HCl salt) . ~ K NMR (CDC1 3 ) δ 1.44 (m, IH) , 1.6 (m, IH) , 2.00 (m 2H) , 2.8 (dt, 2H, J=12, 3), 2.92 (m, IH) , 3.26 (m, IH) , 3.4 (d, IH, J=10) , 3.52 (s, 3H) , 3.53 (d, IH, J=10) , 3.78 (s 3H) , 3.84 (m, IH) , 3.90 (d, IH, J=3), 6.52 (d, IH, J=10) 6.72 (d, IH, J=10) , 6.84 (d, IH, J=10) , 7.82 (m, 5H) . HRMS Calc'd for C 20 H 26 N 2 O 2 : 326.2058. Found: 326.1991 Anal, calc'd for C 20 H 26 N 2 O 2 «2HCl*l/2 H 2 0: C, 58.82; H 7.16; N, 6.86. Found C, 58.63; H, 7.26; N, 6.81. EXAMPLE 30 Cis-3- (5-bromo-2-methoxy-3-methylbenzyl) amino-2 - phenylpiperidine M.p. 236-238°C (HCl salt). -H NMR (CDCl j ) δ 1.44 (m, IH) , 1.64 (m, IH) , 1.90 (m IH) , 2.16 (s, 3H) , 2.80 (m, 2H) , 3.26 (m, IH) , 3.36 (d, IH J=12) , 3.43 (s, IH) , 3.52 (d, IH, J=12) 3.90 (m, IH) , 6.9 (Ξ, IH) , 7.10 (s, IH) , 7.34 (m, 5H) . HRMS calc'd for C 20 H 25 BrN 2 0 : 388.1144. Found: 388.1153 EXAMPLE 31 (2S , 3S) -3- (2 , 4-dimethoxybenzyl) amino-2-phenylpiperidine -B NMR (CDC1 3 ) δ 1.4 (m, IH) , 1.58 (m, IH) , 1.94 (m 2H) , 2.1 (m, IH) , 2.8 (m, 2H) , 3.28 (m, IH) , 3.34 (d, IH J=15) , 3.38 (s, 3H) , 3.64 (d, IH, J=15) ) , 3.76 (s, 3H) , 3.8 (d, IH, J=3), 6.24 (d, IH, J=3) , 6.30 (dd, IH, J=10, 3) 6.86 (d, IH, J=10) , 7.26 (m, 5H) . HRMS Calc'd for C 20 H 26 N 2 O 2 : 326.1988: Found: 326.1986 Anal, calc'd for C 20 H 26 N 2 O 2 * »2HCl«l/4H 2 O: C, 59.48; H, 7.11 N, 6.94. Found: C, 59.40; H, 6.96; N, 6.95. EXAMPLE 32 C2S , 3S) -3- (2-Cvclopentyloxybenzyl) amino-2 -phenylpiperidine M.p. 230-232°C (HCl salt) . -H NMR (CDCI 3 ) δ 1.75 (m, 13H) , 2.14 (m, IH) , 2.80 (dt, 2H, J=12, 3), 2.90 (m, IH) , 3.28 (m, IH) , 3.36 (d, IH, J=15) , 3.60 (d, IH, J=15) , 3.88 (broad s, IH) , 4.58 (m, IH) , 6.74 (m, 2H) , 6.84 (d, IH, J=10) , 7.12 (m, IH) , 7.30 (m, 5H) . HRMS calc'd for C 23 H 40 N 2 O: 350.2351. Found: 350.2332. Anal, calc'd for C^oN- ^HCl^^O: C; 60.12; H, 7.33; N, 6.10. Found C, 59.10; H, 7.19; N, 6.09. EXAMPLE 33 (2S, 3S) -3-(2-Cvclopentyloxy-5-methoxybenzyl. amino-2- phenylpiperidine M.p. 217-219°C (HCl salt) . • H NMR (CDC1 3 ) δ 1.66 (m, 13H) , 2.14 (m, IH) , 2.82 (dt, 2H, J=12, 3), 2.92 (m, IH) , 3.14 (m, 2H) , 3.54 (d, IH, J=15) , 3.72 (S, 3H) , 3.90 (d, IH, J=15) , 4.50 (m, IH) , 6.64 (m, 3H) , 7.30 (m, 5H) . HRMS calc'd for C 24 H 32 N 2 0 2 : 380.2456. Found: 380.2457. Anal, calc'd for C 24 H 32 N 2 0 2 »2HC1'»H 2 0: C, 60.14; H, 7.70; N, 5.94. Found C, 61.05; H, 7.67; N, 5.92. EXAMPLE 34 ( 2S , 3S) -3- (5-tert-Butyl-2-methoxybenzyl) amino-2 - phenylpiperidine M.p. 262-264°C (HCl salt). • H NMR (CDCI 3 ) δ 1.22 (s, 9H) , 1.38 (m, 2H) , 1.90 ( , IH) , 2.14 (m, IH) , 2.80 (m, 2H) , 3.26 (m, IH) , 3.36 (d, IH, J=15) , 3.44 (s, 3H) , 3.62 (d, IH, J=15) , 3.86 (d, IH, J=3) , 6.60 (d, IH, J=10) , 7.00 (d, IH, J=3), 7.12 (m, IH) , 7.26 (m, 5H) . HRMS calc'd for C 23 H 32 N 2 0: 352.2507. Found: 352.2512. Anal, calc'd for C 23 H 32 N 2 0»2HC1*0.5H 2 0: C, 63.58; H, 8.12; N, 6.45. Found C, 63.75; H, 8.00; N, 6.42. EXAMPLE 35 f 2 S , 3 S ) -3 - ( 5-sec-Butyl-2 -methoxybenzy 1 ) amino-2 - phenylpiperidine M.p. 260-263°C (HCl salt) . Η NMR (CDCI 3 ) δ 0.8 (2t, 3H, J=6) , 1.16 (2d, 3H, J=7) , 1.5 (m, 4H) , 1.9 (m, IH) , 2.12 (m, IH) , 2.46 (m, IH) , 2.8 (m, 3H) , 3.28 (m, IH) , 3.42 (d, IH, J=15) , 3.44 (s, 3H) 3.66 (d, IH, J=15) , 3.90 (d, IH, J=3 ) , 6.60 (d, IH, J=10) 6.78 (broad s, IH) , 6.92 (d, IH, J=10) , 7.3 ( , 5H) . HRMS calc'd for C 23 H 32 N 2 0: 352.2507. Found: 352.2525 Anal, calc'd for C 23 H 32 N 2 0*2HC1»H 2 0: C, 62.29; H, 8.18; N 6.32. Found C, 62.95; H, 7.62; N, 6.61. EXAMPLE 36 (2S , 3S) -3- ( 5-Fluoro-2-methoxybenzylamino) -2- phenylpiperidine M.p. > 270°C (HCl salt) . l ΕL NMR (CDC1 3 ) δ 1.38 (m, IH) , 1.56 (m, IH) , 1.90 (m IH) , 2.06 (m, IH) , 2.66 (m, 2H) , 3.26 (m, IH) , 3.30 (d, IH J=15), 3.38 (S, 3H) , 3.56 (d, IH, J=15) , 3.86 (d, IH, J=3), 6.52 (m, IH) , 6.64 (dd, IH, J=10, 3), 6.70 (dt, IH, J=10 3), 7.24 (m, 5H) . Anal, calc'd for C 19 H 23 FN 2 0*5HC1 •0.75H 2 O: C, 57.57; H, 6.61; N, 7.06. Found: C, 57.83, H, 6.31; N, 7.06. EXAMPLE 37 f2S,3S)-3-(4 ,5-Dif luoro-2-methoxybenzyl) amino-2- phenylpiperidine l H NMR (CDC1 3 ) δ 1.36 (m, IH) , 1.55 (m, IH) , 1.84 (m, IH) , 2,02 (m, IH) , 2.72 (m, 2H) , 3.20 (m, IH) , 3.26 (d, IH, J=14) , 3.42 (s, 3H) , 3.52 (d, IH, J=14) , 3.84 (d, IH, J=3), 6.42 (dd, IH, J=6, 12) , 6.70 (dd, IH, J=8 , 10), 7.20 (m, 5H) . Anal, calc'd for C 19 H 22 F 2 N 2 O»2HCl*0.55H 2 0: C, 54.96; H, 6.09; N, 6.75. Found C, 54.65, H, 5.69; N, 6.74. EXAMPLE 38 C2S , 3S) -3- (2-Acetamidobenzyl) amino-2-phenylpiperidine M.p. 187-195°C (HCl salt). l H NMR (CDC1 3 ) δ 1.52 ( , IH) , 1.61 (ε, 3H) , 1.70 ( , IH) , 2.10 (m, 2H) , 2.80 (m, 2H) , 3.18 (m, IH) , 3.32 (d, IH, J=16) , 3.54 (d, IH, J=16), 3.89 (d, IH, J=3) , 6.88 (m, 2H) 7.26 (m, 7H) . HRMS calc'd for C 20 H 25 N 3 O: 323.1997. Found: 323.1972. EXAMPLE 39 (2S.3S) -3-f2-Methoxybenzyl) amino-2-phenylpiperidine Η NMR (CDC1 3 ) δ 1.36 (m, IH) , 1.54 (m, IH) , 2. (m, 2H) , 2.78 (m, 2H) , 3.23 (m, IH) , 3.36 (d, IH, J=14) , 3.41 (s, 3H) , 3.63 (d, IH, J=14), 3.83 (broad S, IH) , 6.6 (d, IH, J=8) , 6.74 (t, IH, J=7), 6.91 (d, IH, J=7) , 7.08 (t, IH, J=8) , 7.12 (m, 5H) . EXAMPLE 40 (2S, 3S) -3- (2-Methoxy-5-methylmercaptobenzylamino) -2 phenylpiperidine hydrochloride M.P. 257 - 259°C (dec.) l H NMR (free base; CDC1 3 ) δ 1.32 (m, IH) , 1.50 (m, IH) , 1.82 (m, IH) , 2.04 (m, IH) , 2.30 (s, 3H) , 2.72 (m, 2H) , 3.18 (m, IH) , 3.26 (d, IH, J=15) , 3.36 (s, 3H) , 3.54 (d, IH, J=15) , 3.80 (d, IH, J=3), 6.52 (d, IH, J=10) , 6.90 (d, IH, J=3), 7.04 (dd, IH, J=3, 10), 7.2 (m, 5H) . HRMS calc'd for C 20 H 26 N 2 OS: 342.1760. Found: 342.1770. Anal, calc'd for C 20 H 26 N 2 OS«2HCl«0.25H 2 O: C, 57.20; H, 6.84; N, 6.67. Found: C, 57.35; H, 6,76; N, 6.61. EXAMPLE 41 ( 2S, 3S) -3- (2-Methoxy-5-methylsulf oxybenzylamino . -2 phenylpiperidine hydrochloride M.P. 209°C (dec) . • H NMR (free base; CDC1 3 ) δ 1.40 (m, IH) , 1.56 (m, IH) , 1.90 (m, IH) , 2.10 (m, IH) , 2.59, 2.62 (2S, 3H) , 2.76 (m, 2H) , 3.22 ( , IH) , 3.42 (m, IH) , 3.49, 3.52 (2S, 3H) , 3.6 (m, IH) , 3.86 (d, IH, J=3) , 6.76 (m, IH) , 7.24 (m, 6H) , 7.4 ( , IH) . HRMS calc'd for C 20 H 27 N 2 O 2 S (M+l) : 359.1787. Found: 359.1763. EXAMPLE 42 (2S, 3S) -3-(2-Methoxy-5-methylsulfonylbenzylamino) -2 phenylpiperidine hydrochloride M.P. > 260°C. Η NMR (free base; CDC1 3 ) δ 1.40 (m, IH) , 1.58 (m, IH) , 1.88 (m, IH) , 2.10 (m, IH) , 2.78 (m, 2H) , 2.96 (s, 3H) , 3.24 (m, IH) , 3.38 (d, IH, J=15) , 3.54 (s, 3H) , 3.66 (d, IH, J=15) , 3.90 (d, IH, J=3) , 6.74 (d, IH, J=10) , 7.26 (m, 5H) 7.58 (d, IH, J=3), 7.72 (d, IH, J=10) . HRMS calc'd for C 20 H 26 N 2 O 3 S: 374.1658. Found: 374.1622 EXAMPLE 43 (2S.3S)-3- ( 2-Methoxy-5-phenoxybenzylamino) -2 phenylpiperidine hydrochloride M.P. > 250°C. ~ E NMR (free base; CDC1 3 ) δ 1.34 (m, IH) , 1.74 ( , 2H) 2.06 (m, IH) , 2.76 (m, 2H) , 3.22 (m, IH) , 3.32 (d, IH J=15) , 3.44 (s, 3H) , 3.60 (d, IH, J=15) , 3.85 (d, IH, J=3) 6.60 (d, IH, J=9), 6.67 (d, IH, J=3) , 6.78 (dd, IH, J=6,9) 6.86 (d, 2H) , 7.00 (t, IH, J=6) , 7.22 (m, 7H) . HRMS calc'd for C 25 H 28 N 2 0 2 : 388.2151. Found: 382.2137 EXAMPLE 44 (2S r 3S) -3- f 2-Methoxy-5-N-methγlmethylsulf onamido benzylamino) -2 -phenylpiperidine hydroohloride -E NMR (free base; CDC1 3 ) δ 1.42 (m, IH) , 1.74 (m, 2H) , 2.12 (m, IH) , 2.78 (m, 5H) , 3.20 (s, 3H) , 3.24 (m, IH) , 3.3 (d, IH, J=15) , 3.52 (S, 3H) , 3.64 (d, IH, J=15) , 3.89 (d, IH, J=3), 6.64 (d, IH, J=9) , 6.98 (d, IH, J=3) , 7.14 (dd, IH, J=3, 9), 7.26 (m, 5H) . HRMS calc'd for C 21 H 29 N 3 0 3 S: 403.1992. Found: 403.1923. Anal, calc'd for C 21 H 29 N 3 0 3 S»2HC1*1/3H 2 0: C, 52.28; H, 6.61; N, 8.71. Found: C, 52.09; H, 6.63; N, 8.68. EXAMPLE 45 (2S,3S)-3-(2,2, 2-Trif luoroethoxybenzylamino) -2 phenylpiperidine hydrochloride M.P. > 275°C. -E NMR (free base; CDC1 3 ) δ 1.44 (m, IH) , 1.62 (m, IH) , 1.90 (m, IH) , 2.10 (m, IH) , 2.82 (m, 2H) , 3.26 (m, IH) , 3.38 (d, IH, J=15) , 3.66 (d, IH, J=15) , 3.92 (d, IH, J=3) , 4.06 (m, 2H) , 6.66 (d, IH, J=10) , 6.94 (m, 2H) , 7.16 (m, IH) , 7.30 (m, 5H) . HRMS calc'd for C 20 H 24 F 3 N,O(M+l) : 365.1835. Found: 385.1908. Anal, calc'd for C 20 H 23 F 3 N 2 O»2HCl*l/3H 2 O: C, 54.19; H, 5.84; N, 6.32. Found: C, 54.22; H, 5.57; N, 6.42. EXAMPLE 46 (2S.3S) -3-r5-Chloro-2-(2 ,2 , 2 -trif luoroethoxy) benzyl- aminol -2 -phenylpiperidine hydrochloride M.P. 267-269°C. -H NMR (free base; CDC1 3 ) δ 1.40 (m, IH) , 1.60 (m, IH) , 1.82 (m, IH) , 2.02 (m, IH) , 2.76 (m, 2H) , 3.20 (m, IH) , 3.28 (d, IH, J=15) , 3.52 (d, IH, J=15) , 3.84 (d, IH, J=3) , 4.00 (m, 2H) , 6.54 (d, IH, J=10) , 6.92 (d, IH, J=3), 7.04 (m, IH) , 7.24 (m, 5H) . HRMS calc'd for C 20 H 22 ClF 3 N 2 O: 398.1368. Found: 398.1352. Anal, calc'd for C 20 H 22 ClF 3 N 2 O»2HCl: C, 50.91; H, 5.13; N, 5.94. Found: C, 50.89; H, 4.84; N, 5.93. EXAMPLE 47 (2S , 3S) -3- (3-Trifluoromethoxybenzylaroino) -2 - phenylpiperidine hydrochloride M.P. > 275°C. -E NMR (free base; CDC1 3 ) δ 1.4 (m, IH) , 1.54 (m, IH) , 1.80 (m, IH) , 1.96 (m, IH) , 2.74 (m, 2H) , 3.18 (m, IH) , 3.30 (d, IH, J=15) , 3.46 (d, IH, J=15) , 3.82 (d, IH, J=3) , 6.80 (S, IH) , 6.84 (d, IH, J=10) , 6.92 (m, IH) , 7.12 (m, IH) , 7.24 (m, 5H) . HRMS calc'd for C, 9 H 2 ,F 3 N 2 0: 350.1601. Found: 350.1609. Anal, calc'd for C 19 H 21 F 3 N 2 0*2HC1: C, 53.91; H, 5.48; N, 6.62. Found: C, 53.84; H, 5.07; N, 6.59. EXAMPLE 48 (2S,3S)-3-(5-t-Butyl-2-trif luoromethoxybenzylamino) -2- phenylpiperidine hydrochloride M.P. 262-264°C. [ E NMR (free Base; CDC1 3 ) δ 1.20 (s, 9H) , 1.40 (m, IH) , 1.52 (m, IH) , 1.84 (m, IH) , 2.06 (m, IH) , 2.80 (m, 2H) , 3.22 (m, IH) , 3.38 (d, IH, J=15) , 3.58 (d, IH, J=15) , 3.86 (d, IH, J=3) , 6.98 (m, IH) , 7.12 (m, 2H) , 7.26 (m, 5H) . HRMS calc'd for C-^H^F^O: 406.2225. Found: 406.2271. Anal, calc'd for C 23 H 29 F 3 N 2 0«2HC1«1/3H 2 0: C, 56.92; H, 6.56; N, 5.77. Found: C, 56.99; H, 6.41; N, 6.03. EXAMPLE 49 f 2S,3S) -3-r5-Isopropyl-2- (2,2, 2-trif luoroethoxy) benzyla inol -2-phenylpiperidine hydrochloride M.P. > 280°C. X H NMR (free base; CDC1 3 ) δ 1.12.(m, 6H) , 1.4 (m, IH) 1.62 ( , IH) , 1.82 (m, IH) , 2.08 (m, IH) , 2.76 (m, 3H) , 3.2 (m, IH) , 3.30 (d, IH, J=15) , 3.38 (d, IH, J=15) , 3.82 (d IH, J= ** 3), 4.02 (m, 2H) , 6.56 (d, IH, J=10) , 6.78 (d, IH J=3), 6.94 (m, IH) , 7.24 (m, 5H) . HRMS calc'd for C 23 H 30 F 3 N 2 O (M+l) : 407.2303. Found 407.2287. Anal, calc'd for C 23 H 29 F 3 N 2 0»2HC1«1/2H 2 0: C, 56,55, H 6.60; N, 5.70. Found: C, 56.17: H, 6.39; N, 5.77. EXAMPLE 50 ( 2S , 3S) -3- (2-Methoxy-5-methylaminomethylbenzylamino) -2 phenylpiperidine hydrochloride M.P. 242°C (dec) . -E NMR (free base; CDC1 3 ) δ 1.36 (m, IH) , 1.58 (m, IH) 1.90 (m, IH) , 2.10 (m, IH) , 2.38 (s, 3H) , 2.80 (m, 2H) , 3.2 (m, IH) , 3.42 (m, 4H) , 3.56 (s, 2H) , 3.64 (d, IH, J=15) 3.86 (d, IH, J=3), 6.60 (d, IH, J=10) , 6.86 (d, IH, J=3) 7.02 (m, IH) , 7.26 (m, 5H) . HRMS calc'd for C 21 H 30 N 3 O (M+l) : 340.2382. Found: 340.2400. EXAMPLE 51 ( 2S , 3S) -3-r 5-Dimethylamino-2- (2 , 2 , 2-trif luoroethoxy) benzy lamino 1 -2-phenylpiperidine hydrochior ide . M.P. 250-252°C. -Η NMR (free base; CDC1 3 ) δ 1.40 (m, IH) , 1.60 (m, IH) , 1.86 (m, IH) , 2.10 (m, IH) , 2.82 (m, 8H) , 3.22 (m, IH) , 3.34 (d, IH, J=15) , 3.58 (d, IH, J=15) , 3.88 (d, IH, J=3), 4.0 (m, 2H) , 6.42 (d, IH, J=3), 6.50 (m, IH) , 6.64 (d, IH, J=10) , 7.30 (m, 5H) . HRMS calc'd for C 2 ,H 28 F 3 N 3 0 : 407.2178. Found: 407.2179. EXAMPLE 52 ( 2S , 3S) -3- ( 2-Dif luoromethoxy-5-methγlmercaptobenzyl amino) -2-phenylpiperidine hydrochloride M.P. 254-256°C. -E NMR (free base: CDC1 3 ) δ 1.45 (m, IH) , 1.60 (m, IH) , 1.80 (m, IH) , 2.10 (m, IH) , 2.40 (s, 3H) , 2.80 (m, 2H) , 3.20 (m, IH) , 3.30 (d, IH, J=15) , 3.55 (d, IH, J=15) , 3.90 (d, IH, J=3) , 6.10 (t, IH, J=85) , 6.95 (m, 3H) , 7.25 (m, 5H) . HRMS calc'd for C 20 H 25 C1 2 F 2 N 2 OS(M+1) : 379.1650. Found: 379.1668. Anal, calc'd for C 20 H 24 N 2 OF 2 Cl 2 «2HCl*l/4H 2 O: C, 52.69; H, 5.86; N, 6.14. Found: C, 52.36; H, 5.86; N, 6.14. EXAMPLE 53 f 2S , 3S) -3- ( 5-sec-Butyl-2-methoxybenzyl) amino-2 - phenylpiperidine M.P. 260-263°C (HCl salt) . -H NMR (free base; CDC1 3 ) δ 0.8 (2t, 3H, J=6) , 1.16 (2d, 3H, J=7), 1.5 (m, 4H) , 1.9 ( , IH) , 2.12 (m, IH) , 2.46 (m, IH) , 2.8 (m, 3H) , 3.28 (m, IH) , 3.42 (d, IH, J=15) , 3.44 (s, 3H) , 3.66 (d, IH, J=15) , 3.90 (d, IH, J=3) , 6.60 (d, IH, J=10) , 6.78 (broad s, IH) , 6.92 (d, IH, J=10) , 7.3 (m, 5H) . HRMS calc'd for C 23 H 32 N 2 0: 352.2507. Found: 352.2525. EXAMPLE 54 ( 2S , 3S) -3- ( 4-Amino-5-chloro-2-methoxybenzyl) amino-2- phenylpiperidine hydrochloride M.P. 200-203°C (dec) . -E NMR (free base; CDC1 3 ) δ 1.35 (m, IH) , 1.56 ( , IH) , 1.86 (m, IH) , 2.05 (m, IH) , 2.75 (m, 2H) , 3.22 (m, 2H) , 3.36 (s, 3H) , 3.48 (d, IH, J=12) , 3.84 (d, IH, J=2) , 6.08 (s, IH) , 6.78 (s, IH) , 7.24 (m, 5H) . HRMS calc'd for C, 9 H 24 C1N 3 0: 345.1604. Found: 345.1589. EXAMPLE 55 f2S,3S)-3-(2-Methoxy-5-phenylbenzylamino. -2- phenylpiperidine hydrochloride M.P. 238-239°C (dec) . *H NMR (free base; CDC1 3 ) δ 1.38 (m, IH) , 1.60 (m, IH) , 1.88 (m, IH) , 2.12 (m, IH) , 2.80 (m, 2H) , 3.23 (m, IH) , 3.45 (m, 4H) , 3.70 (d, IH, J=12) , 3.86 (d, IH, J=3) , 6.70 (d, IH J=6) , 7.34 ( , 12H) . HRMS calc'd for C^H^N j O: 372.2197. Found: 372.2172. EXAMPLE 56 (2S , 3S) -2-Phenyl-3-fquinolin-8-yl)methylpiperidin hydrochloride M.P. 252-253°C (dec). l E NMR (free base; CDC1 3 ) δ 1.38 ( , IH) , 1.58 ( , IH) 1.94 (m, IH) , 2.17 (m, IH) , 2.78 (m, 2H) , 3.24 (m, IH) , 3.8 (d, IH, J=3), 3.96 (d, IH, J=15) , 4.28 (d, IH, J=15) , 7.1 (m, 6H) , 7.32 (m, 2H) , 7.58 (t, IH, J=4) , 7.98 (d, IH, J=6) , 8.46 (m, IH) . HRMS calc'd for C 21 H 23 N 3 : 317.1887. Found: 317.1883. EXAMPLE 57 ( 2S , 3S) -3- f 5-He tyloxy-2-methoxybenzyl) amino-2 phenylpiperidine hydrochloride M.P. 230°C (dec) . 'H fflR (free base; CDC1 3 ) δ 0.90 (m, 2H) , 1.38 (m, 10H) , 1.76 (m, 4H) , 2.12 (m, IH) , 2.80 (m, 2H) , 3.26 (m, IH) , 3.38 (d, IH, J=16) , 3.42 (s, 3H) , 3.62 (d, IH, J=15) , 3.82 (t, 2H, J=6) , 3.88 (d, IH, J=3), 6.62 (m, 3H) , 7.28 (m, 5H) . HRMS calc'd for C 26 H 38 N 2 0 2 : 410.2928. Found: 410.2953. EXAMPLE 58 f 2S , 3S) -3- ( 2-Heptyloxy-5-methoχybenzyl) amino-2 - phenylpiperidine hydrochloride M.P. 212-213°C (dec). 'H NMR (free base; CDC1 3 ) δ 0.90 ( , 3H) , 1.60 (m, 13H) , 2.12 (m, IH) , 2.80 (m, 2H) , 3.26 (m, IH) , 3.36 (d, IH, J=15) , 3.62 (m, 6H) , 3.86 (d, IH, J=3), 6.60 (m, 3H) , 7.23 (m, 5H) . HRMS calc'd for C 26 H 38 N 2 0 2 : 410.2928. Found: 410.2912. EXAMPLE 59 (2S r 3S)-3- f 5-Heptγl-2-methoxybenzyl ) amino-2 - phenylpiperidine hydrochloride M.P. 242-243°C (dec). 'H NMR (free base; CDC1 3 ) δ 0.88 ( , 3H) , 1.60 (m, 13H) , 2.14 (m, IH) , 2.44 (t, 2H, J=6) , 2.78 (m, 2H) , 3.26 (m, IH) , 3.40 (m, 4H) , 3.64 (d, IH, J=15) , 3.86 (d, IH, J=2) , 6.5 (d, IH, J=6) , 6.75 (d, IH, J=2) , 6.92 (d, IH, J=6) , 7.26 (m, 5H) . HRMS calc'd for C 26 H 38 N 2 0: 394.2977. Found: 394.3009. EXAMPLE 60 ( 2S .3S) -3- ( 2-Methoxy-5-n-propylbenzyl) amino-2 phenylpiperidine hydrochloride M.P. 245-247°C (dec) . • H NMR (free base; CDC1 3 ) δ 0.9 (t, 3H, J=10) , 1.4 (m, IH) , 1.54 (m, 2H) , 1.92 (m, IH) , 2.14 (m, IH) , 2.44 (t, 2H, J=6) , 2.80 (m, 2H) , 3.26 (s, IH) , 3.40 (d, IH, J=15) , 3.44 (Ξ, 3H) , 3.66 (d, IH, J=15) , 3.90 (s, IH) , 6.56 (d, IH, J=10) , 6.76 (S, IH) , 6.92 (d, IH, J=10) , 7.26 (m, 5H) . HRMS calc'd for C 22 H 30 N 2 O: 338.2351. Found: 338.2339. Anal, calc'd for C 22 H 30 N 2 O«2HCl»0.25 H 2 0: C, 63.57, H, 7.81; N, 6.74. Found: C, 63.59; H, 7.66; N, 6.73. EXAMPLE 61 (2S,3S)-3-(4.5 -Dimethy 1-2 -methoxy benzyl) amino-2 phenylpiperidine hydrochloride M.P. 269-270°C. ■ E NMR (free base; CDC1 3 ) <!> 1.40 (m, IH) , 1.60 (m, IH) , 1.96 (m, 2H) , 2.14 (s, 3H) , 2.18 (s, 3H) , 2.80 (m, 2H) , 3.30 (m, IH) , 3.40 (d, IH, J=15) , 3.42 (s, 3H) , 3.62 (d, IH , J=15) , 3.90 (d, IH, J=3) , 6.48 (s, IH) , 6.70 (s, IH) , 7.28 (m, 5H) . HRMS calc'd for C 21 H 28 N 2 0: 324.2195. Found: 324.2210. Anal, calc'd for C 2 ιH 28 N 2 O»2HCl»0.25H 2 O: C, 62.80; H, 7.60; N, 6.99. Found: C, 62.64; H, 7.31; N, 6.86. EXAMPLE 62 (2S.3S) -3-(5-t-Butyl-2-hvdroxy benzyl) amino-2 phenylpiperidine hydrochloride M.P. 267-269°C (dec) . Η NMR (free base: CDC1 3 ) δ 1.3 (s, 9H) , 1.6 ( , 3H) , 2.18 (m, IH) , 2.82 (m, IH) , 2.98 (m, IH) , 3.22 (m, IH) , 3.44 (d, IH, J=15) , 3.56 (d, IH, J=15) , 3.92 ( , IH) , 6.70 ( , 2H) , 7.14 (m, IH) , 7.40 (m, 5H) . HRMS Calc'd for C 22 H 30 N 2 O: 338.2351. Found: 338.2384. EXAMPLE 63 (2S , 3S) -3- (5-Carbomethoxy-2-methoxybenzyl) amino-2 phenylpiperidine hydrochloride M.P. 238-240°C. -E NMR (free base; CDC1 3 ) δ 1.4 (m, IH) , 1.6 ( , IH) 1.88 (m, IH) , 2.1 (m, IH) , 2.75 (m, 2H) , 3.2 (m, IH) , 3.3 (d, IH, J=15) , 3.45 (s, 3H) , 3.7 (d, IH, J=15) , 3.85 ( 4H) , 6.65 (d, IH, J=10) , 7.2 (m, 5H) , 7.70 (d, IH, J=3) 7.85 (m, IH) . HRMS calc'd for C 2 ιH 26 N 2 0 3 : 354.1937. Found: 354.1932 EXAMPLE 64 f2S,3S) -3- (5-n-Butyl-2-methoxγbenzyl) amino-2 phenylpiperidine hydrochloride M.P. 252-253°C. X H NMR (free base; CDC1 3 ) δ 0.88 (t, 3H, J=10) , 1.38 (m 3H) , 1.56 (m, 3H) , 1.96 (m, 2H) , 2.18 (m, IH) , 2.50 (t, 2H J=10) , 2.86 (m, 2H) , 3.30 (m, IH) , 3.44 (d, IH, J=15) , 3.4 (S, 3H) , 3.68 (d, IH, J=15) , 3.82 (d, IH, J=3 ) , 6.62 (d, IH J=10) , 6.80 (s, IH) , 6.86 (d, IH, J=10) , 7.3 (m, 5H) . HRMS calc'd for C 23 H 32 N 2 0: 352.2507. Found: 352.2509 Anal, calc'd for C 23 H 32 N 2 0«2HC1»1/3H 2 0: C, 64.03; H 8.09; N, 6.50. Found: C, 64.39; H, 7.90; N, 6.59. EXAMPLE 65 f 2S , 3S) -3- (5-Isopropyl-2-methoxybenzyl) amino-2 phenylpiperidine hydrochloride M.P. 252-254°C. l E NMR (free base; CDC1 3 ) δ 1.14 (d, 6H, J=6) , 1.36 (m IH) , 1.58 (m, IH) , 1.88 (m, IH) , 2.1 (m, IH) , 2.76 (m, 3H) 3.24 (m, IH) , 3.36 (d, IH, J=15) , 3.42 (s, 3H) , 3.60 (d, IH, J=15) , 3.86 (d, IH, J=3 ) , 6.56 (d, IH, J=10) , 6.80 (d, IH, J=3), 6.84 (m, IH) , 7.24 (m, 5H) . HRMS calc'd for C 22 H 30 N 2 O: 338.2351. Found: 338.2377. Anal, calc'd for C 22 H 30 N 2 O«2HCl*l/4H 2 O: C, 63.52; H, 7.88; N, 6.74. Found: C, 63.33; H, 7.64; N, 6.75. EXAMPLE 66 f 2 S . 3 S ) - 3 - f 2 -D i f luoromethoxy- 5 -N . N dimethylaminobenzyla ino) -2-phenylpiperidine hydrochloride M.P. 243-245°C (dec). -E NMR (free base; CDC1 3 ) δ 1.44 (m, IH) , 1.72 (m, 2H) , 2.10 (m, IH) , 2.84 (m, 8H) , 3.21 (m, IH) , 3.28 (d, IH, J=15) , 3.55 (d, IH, J=15) , 3.88 (d, IH, J=3), 6.08 (t, IH, J=72), 6.36 (d, IH, J=3 ) , 6.46 (dd, IH, J=3,9) , 6.86 (d, IH, J=9), 7.28 (m, 5H) . HRMS calc'd for C 21 H 27 F 2 N 3 0: 375.2122. Found: 375.2138. Anal, calc'd for C 2 ιH 27 F 2 N 3 0«3HCl*l/2H 2 0: C, 51.07; H, 6.44; N, 8.51. Found: C, 50.71; H, 6.08; N, 8.28. EXAMPLE 67 (2S,3S)-3-r2.5fbis-fdif luoro ethoxy) benzyl) amino] -2 phenylpiperidine hydrochloride M.P. 238-239°C. ■ E NMR (free base; CDC1 3 ) δ 1.64 (m, 3H) , 2.04 (m, IH) , 2.76 (m, 2H) , 3.18 (m, IH) , 3.28 (d, IH, J=12) , 3.52 (d, IH, J=12), 3.84 (d, IH, J=3) , 6.12 (t, IH, J=75), 6.40 (t, IH, J=75) , 6.75 (m, 2H) , 6.94 (d, IH, J=9) , 7.24 (m, 5H) . HRMS calc'd for C 20 H 22 F 4 N 2 O 2 : 398.1612. Found: 398.1591. EXAMPLE 68 (2S.3S)-3-(5-t-Butyl-2-difluoromethoxγbenzylamino) -2 phenylpiperidine hydrochloride M.P. 263-264°C (dec) . -E NMR (free base; CDC1 3 ) <5 1.24 (s, 9H) , 1.42 (m, IH) , 1.62 (m, IH) , 1.80 (m, IH) , 2.10 ( , IH) , 2.80 (m, 2H) , 3.24 (m, 2H) , 3.58 (d, IH, J=12) , 3.87 (brs, IH) , 6.18 (t, IH, J=72), 6.86 (d, IH, J=6) , 7.00 (brs, IH) , 7.12 (m, IH) , 7.24 (m, 5H) . HRMS calc'd for C 23 H 30 F 2 N 2 O: 388.2321. Found: 388.2336. EXAMPLE 69 (2S.3S) -3-(5-Dimethylamino-2-methoxybenzylamino) -2 phenylpjperidine hydrochloride M.P. > 275°C. *H NMR (free base; CDC1 3 ) δ 1.34 (m, IH) , 1.70 (m, 2H) , 2.10 (m, IH) , 2.76 (m, 8H) , 3.20 (m, IH) , 3.34 (m, 4H) , 3.5 (d, IH, J=12) , 3.82 (d, IH, J=2) , 6.50 (m, 3H) , 7.22 (m 5H) . HRMS calc'd for C 2 ιH 29 N 3 0: 339.2306. Found: 339.2274 Anal, calc'd for C 21 H 29 N 3 0*3HC1«H 2 0: C, 54.02; H, 7.34 N, 9.00. Found: C, 53.84; H, 7.55; N, 8.92. EXAMPLE 70 f 2S , 3S) -3- (2-Isopropoxy-5-trif luoromethoxybenzylamino) 2-phenylpiperidine hydrochloride M.P. 245-246°C (dec) . -E NMR (free base: CDC1 3 ) δ 1.08 (d, 3H, J=6) , 1.12 (d 3H, J=6) , 1.40 (m, IH) , 1.64 (m, IH) , 1.87 (m, IH) , 2.08 (m IH) , 2.78 (m, 2H) , 3.02 (m, IH) , 3.34 (d, IH, J=15) , 3.5 (d, IH, J=15) , 3.85 (d, IH, J=2) , 4.28 (m, IH) , 6.01 (d, IH J=9), 6.82 (m, IH) , 6.91 (m, IH) , 7.24 (m, 5H) . HRMS calc'd for C 22 H 27 F 3 N 2 0 2 : 408.2024. Found: 408.2019 Anal, calc'd for C 22 H 27 F 3 N 2 0 2 » 2HC1 : C, 54.89; H, 6.07, N 5.82. Found: C, 54.50; H, 6.24; N, 5.78. EXAMPLE 71 (2S , 3S) -3- (2-Dif luoromethoxy-5-trif luoromethoxy benzylamino) -2-phenylpiperidine hydrochloride M.P. 257-259°C (dec) . -E NMR (free base; CDC1 3 ) δ 1.44 (m, IH) , 1.58 (m, IH) , 1.78 (m, IH) , 2.03 (m, IH) , 2.78 (m, 2H) , 3.20 (m, IH) , 3.3 (d, IH, J=15) , 3.54 (d, IH, J=15) , 3.87 (d, IH, J=2) , 6.1 (t, IH, J=72) , 6.94 (m, 3H) , 7.26 (m, 5H) . HRMS calc'd for C 20 H 21 F 5 N 2 O 2 : 416.1523. Found: 416.1501. Anal, calc'd for C 20 H 2 ιF 5 N 2 O 2 »2HCl-»l/3H 2 O: C, 48.50; H, 4.81; N, 5.65. Found: C, 48.45; H, 4.57; N, 5.66. EXAMPLE 72 (2S.3S) -3- (2-Ethoxy-5-trif luoromethoxybenzylamino) -2 phenylpiperidine hydrochloride M.P. > 275°C (dec) . l E NMR (free base; CDC1 3 ) δ 1.13 (t, 3H, J=6) , 1.38 ( , IH) , 1.70 (m, 2H) , 2.06 (m, IH) , 2.74 (m, 2H) , 3.22 (m, IH) , 3.30 (d, IH, J=15) , 3.68 (m, 3H) , 3.84 (br S, IH) , 6.55 (d, IH, J=9), 6.79 (br s, IH) , 6.90 (m, IH) , 7.2 (m, 5H) . HRMS calc'd for C^H^F^O, : 394.1868. Found: 394.1875. Anal. calc'd for C 21 H 25 F 3 N 2 0 2 *2HC1: C, 53.97; H, 5.82; N, 6.00. Found: C, 53.85; H, 5.79; N, 5.95. EXAMPLE 73 (2S , 3S) -3- ι.5-Ethyl-2-methoxybenzylamino) -2- phenylpiperidine hydrochloride ■ E NMR (free base, CDC1 3 ) δ 1.16 (t, 3H, J=9) , 1.36 (m, IH) , 1.57 (m, IH) , 1.88 (m, IH) , 2.12 (m, IH) , 2.48 (q, 2H) , 2.76 (m, 2H) , 3.24 (m, IH) , 3.38 (m, 4H) , 3.60 (d, IH, J=12) , 3.86 (d, IH, J=3) , 6.57 (d, IH, J=6) , 6.74 (d, IH, J=3) , 6.92 (dd, IH, J=3,6) , 7.24 (m, 5H) . HRMS calc'd for C 2 ,H 28 N 2 0: 324.2202. Found: 324.2202. EXAMPLE 74 (2S, 3S) -3-(2-Dif luoromethoxy-5-nitrobenzylamino) -2- phenylpiperidine hydrochloride "E NMR (free base; CDC1 3 ) δ 1.50 (m, IH) , 1.66 (m, IH) , 1.98 (m, 2H) , 2.82 (m, 2H) , 3.28 (m, IH) , 3.42 (d, IH, J=15) , 3.64 (d, IH, J=15) , 3.95 (d, IH, J=2) , 6.30 (t, IH, J=72) , 7.08 (d, IH, J=8) , 7.30 (m, 5H) , 8.04 (m, 2H) . FAB HRMS calc'd for C 19 H 21 F 2 N 3 0 3 (M+l) : 378.1629. Found: 378.1597. EXAMPLE 75 ( 2S .3S) -3- (2-Dif luoromethoxy-5-isopropγlbenzγlamino) -2- phenylpiperidine hydrochloride M.P. 245-247°C (dec) . -E NMR (free base; CDC1 3 ) δ 1.19 (2d, 6H, J=7) , 1.50 ( , IH) , 1.75 (m, 2H) , 2.12 (m, IH) , 2.83 (m, 3H) , 3.25 (m, IH) , 3.35 (d, IH, J=14) , 3.60 (d, IH, J=14) , 3.90 (d, IH, J=3 ) , 6.20 (t, IH, J=75) , 6.90 (m, 2H) , 7.00 (m, IH) , 7.30 (m, 5H) . HRMS calc'd for C 22 H 28 F 2 N 2 0: 374.2170. Found: 374.2207. Anal, calc'd for C 22 H 28 F 2 N 2 0»2HC1«1/3H 2 0: C, 58.28; H, 6.67; N, 6.18. Found: C, 58.17; H, 6.52; N, 6.17. EXAMPLE 76 (2S,3S) -3-f 2-Methoxy-5-hydroxybenzylamino) -2- phenylpiperidine hydrochloride M.P. 239-240°C (dec) . ~ E NMR (free base; CDC1 3 ) δ 1.42 (m, IH) , 1.64 ( , IH) 1.90 (m, IH) , 2.16 (m, IH) , 2.82 (m, 2H) , 3.26 (m, IH) , 3. (d, IH, J=15) , 3.42 (S, 3H) , 3.58 (d, IH, J=15) , 3.92 ( IH, J=2) , 6.37 (d, IH, J=2) , 6.52 (m, 2H) , 7.26 (m, 5H) . HRMS calc'd for Ci 9 H 24 N,0 2 : 312.1836. Found: 312.186 EXAMPLE 77 (2S,3S)-3-(2 -Methoχy-5-tr if luoromethoxybenzyl ) -amino- phenylpiperidine hydrochloride M.p. > 250°C. l E NMR (free base, CDC1 3 ) δ 1.36 (s, IH) , 1.54 (m, IH) 1.86 (m, IH) , 2.06 (m, IH) , 2.76 (m, 2H) , 3.22 (m, IH) , 3.3 (d, IH, J=15) , 3.48 (s, 3H) , 3.58 (d, IH, J==15) , 3.85 (d IH, J=3), 6.57 (d, IH, J=9) , 6.80 (d, IH, J=3) , 6.92 (dd IH, J=3, 9), 7.22 (m, 5H) . HRMS calc'd for C 20 H 23 F 3 N 2 O 2 : 380.1711. Found: 380.1704 Anal, calc'd for C 20 H 23 F 3 N 2 O 2 «2HCl * »0.2H 2 O: C 52.57, 5.60, N 6.13. Found: C 52.58, H 5.40, N 5.97. EXAMPLE 78 (2S,3S) -3 -(2-Hydroxy-5 -trif luoromethoxybenzylamino) -2 phenylpiperidine hydrochloride l E NMR (free base; CDC1 3 ) δ 1.60 (m, 3H) , 2.04 ( , IH) 2.76 (m, IH) , 2.88 (m, IH) , 3.18 (m, IH) , 3.42 (s, 2H) , 3.9 (m, IH) , 6.52 (m, IH) , 6.64 (d, IH, J=9) , 6.89 (m, IH) , 7.3 (m, 5H) . HRMS calc'd for C 19 H 21 F 3 N 2 0, : 366.1545. Found: 366.1562 Anal, calc'd for C 19 H 21 F 3 N 2 0 2 «2HC1«1/3H 2 0: C, 51.25; H 4.90; N, 6.29. Found: C, 51.30; H, 4.75; N, 6.22. EXAMPLE 79 (2S,3S)-3-f5-Acetamido-2-(2,2,2-trifluoroethoxy)benzyl amino ~ \-2-phenylpiperidine hydrochloride M.P. > 270°C. l E NMR (free base; CDC1 3 ) δ 1.46 ( , IH) , 1.82 ( , IH) 2.08 (m, IH) , 2.12 (s, 3H) , 2.76 (m, 2H) , 3.20 (m, IH) , 3.4 (d, IH, J=15) , 3.58 (d, IH, J=15) , 3.82 (m, IH) , 4.08 (m 2H) , 6.44 (m, IH) , 6.58 (d, IH, J=10) , 6.78 (m, IH) , 7.2 (m, 5H) , 7.58 ( , IH) . EXAMPLE 80 (2S, 3S) -3-(2-Difluoromethoxy-5-ethylbenzylamino) -2- phenylpiperidine hvdrocholoride M.P. 254-255°C. -H NMR (free base; CDC1 3 ) δ 1.12 (t, 3H, J=10) , 1.36 (m, IH) , 1.44 (m, IH) , 1.82 (m, IH) , 2.10 (m, IH) , 2.48 (q, 2H, J=10) , 2.8 (m, IH) , 3.10 (m, IH) , 3.34 (d, IH, J=15) , 3.58 (d, IH, J=15) , 3.9 (d, IH, J=3) , 6.12 (t, IH, J=85) , 6.78 (s, IH) , 6.90 (m, 2H) , 7.28 (m, 5H) . Anal, calc'd for C 21 H 26 F 2 N 2 0»2HC1: C, 58.19; H, 6.51; N, 6.47. Found: C, 57.90; H, 6.52; N, 6.64. EXAMPLE 81 (2S , 3S) -3- (5-Chloro-2-difluoromethoxylbenzylamino) -2- phenylpiperidine hydrochloride M.P. 272-274°C. l H NMR (free base; CDC1 3 ) δ 1.48 (m, IH) , 1.64 (m, IH) , 1.84 (m, IH) , 2.08 (m, IH) , 2.84 (m, 2H) , 3.24 (m, IH) , 3.34 (d, IH, J=15) , 3.56 (d, IH, J=15) , 3.90 (d, IH, J=3), 6.12 (t, IH, J=70) , 6.90 (d, IH, J=10) , 7.02 (m, IH) , 7.12 (m, IH) , 7.3 (m, 5H) . Anal, calc'd for C, 9 H 2I C1F 2 N 2 0»2HC1«1/3H 2 0: C, 51.20; H, 5.33; N, 6.29. Found: C, 51.03, H, 5.32. N, 6.30. EXAMPLE 82 ( 2S , 3S) -Phenyl -3- (2-trif luoromethoxybenzyl) ami no - piperidine hydrochloride M.p. 231-233°C. -H NMR (free base, CDC1 3 ) δ 1.40 (m, IH) , 1.60 ( , IH) , 1.84 (m, IH) , 2.05 (m, IH) , 2.78 (m, 2H) , 3.22 (m, IH) , 3.42 (d, IH, J=15) , 3.56 (d, IH, J=15) , 3.86 (d, IH, J=3) , 7.08 (m, 4H) , 7.24 (m, 5H) . Mass spectrum: m/z 350 (parent) . Anal, calc'd for Cι 9 H 21 F 3 N 2 O»2HCl«0.25H 2 O: C 53.34, H 5.54, N 6.54. Found: C 53.19, H 5.40, N 6.54.

Claims: CLAIMS A process for preparing a compound of the formul wherein R 1 is aryl selected from indanyl, phenyl an naphthyl; heteroaryl selected from thienyl, furyl, pyridy and quinolyl; and cycloalkyl having 3 to 7 carbon atoms wherein one of said carbon atoms may optionally be replace by nitrogen, oxygen or sulfur; wherein each of said aryl an heteroaryl groups may optionally be substituted with one o more substituents, and said (C 3 -C 7 ) cycloalkyl may optionall be substituted with one or two substituents, sai substituents being independently selected from chloro fluoro, bromo, iodo, nitro, (C ι ~-C \ o) alkyl optionall substituted with from one to three fluoro groups, (Cj-C I0 ) alkoxy optionally substituted with from one to three fluor groups, 0 amino, (C j -C-^alkyl-S-, (Cι-C 10 )alkyl-S II-, (Cι-C I0 )alkyl-SO 2 -, phenyl, phenoxy, (Cι-Cι 0 )alkyl-SO 2 NH-, C JO )alkyl-, (C x -C 10 )alkylamino-di(C,-Cι 0 )alkyl-, cyano, hydroxy1, cycloalkoxy having 3 to 7 carbon atoms, (C x -C 6 )-alkylamino, (C j -C 6 ) dialkylami'no, O O HC INH- and (Cj-CβJalkyl-ICI-NH-, wherein the nitrogen atoms of said amino and (C ! -C 6 ) alkylamino groups may optionally b protected with an appropriate protecting group; and R 2 is thienyl, benzhydryl, naphthyl or phenyl optionally substituted with from one to three substituents independently selected from chloro, bromo, fluoro, iodo, cycloalkoxy having 3 to 7 carbon atoms, (C ] -C 10 )alkyl optionally substituted with from one to three fluoro groups and (C^C j o) alkoxy optionally substituted with from one t three fluoro groups, comprising reacting a compound of th formula wherein R 2 is defined as above, with either (a) a compound o 0 the formula R-CX, wherein R 1 is defined as above and X is leaving group, followed by treatment of the resulting amide with a reducing agent, (b) a compound of the formula R'CH.O, wherein R 1 is defined as above, in the presence of a reducin agent, or (c) a compound of the formula R'OE^X, wherein R 1 i defined as above and X is a leaving group. 2. A process according to claim 1, wherein sai compound of the formula IV is reacted with said compound of the formula R'CHO in the presence of a reducing agent. 3. A process according to claim 2, wherein sai reducing agent is sodium triacetoxyborohydride. 4. A process according to claim 2, wherein sai reducing agent is sodium cyanoborohydride. 5. A process according to claim 2, reaction is conducted in a lower alcohol temperature from about -60°C to about 50°C. 6. A process according to claim 2, reaction is conducted in an acetic acid temperature from about -60°C to about 50°C. 7. A process for preparing a compound of the formula wherein R 1 is aryl selected from indanyl, phenyl an naphthyl; heteroaryl selected from thienyl, furyl, pyridy and quinolyl; and cycloalkyl having 3 to 7 carbon atoms wherein one of said carbon atoms may optionally be replace by nitrogen, oxygen or sulfur; wherein each of said aryl an heteroaryl groups may optionally be substituted with one o more substituents, and said (C 3 -C 7 ) cycloalkyl may optionall be substituted with one or two substituents, sai substituents being independently selected from chloro fluoro, bromo, iodo, nitro, (C^C JQ ) alkyl optionall substituted with from one to three fluoro groups, (C ι -C 10 ) alkoxy optionally substituted with from one to three fluor groups, 0 II amino, (Cj-CjoJalkyl-S-, (C,-Cι 0 )alkyl-S-, (C J -C JQ )alkyl-S0 2 -, phenyl, phenoxy, (Cι-C 10 )alkyl-S0 2 NH-, alkyl-S0 2 NH-(Ca, C 10 )alkyl-, (C^C^)alkylamino-di(C 1 -C 10 )alkyl-, cyano, hydroxyl, cycloalkoxy having 3 to 7 carbon atoms, (C,-^) alkylamino, (C-[-C 6 ) dialkylamino, H wherein the nitrogen atoms of said amino and (Cj-C alkylamino groups may optionally be protected with an appropriate protecting group; and R 2 is thienyl, benzhydryl, naphthyl or phenyl substituted with from one to three substituents independently selected from chloro, bromo, fluoro, iodo, cycloalkoxy having 3 to 7 carbon atoms, (C J -C J Q)alkyl optionally substituted with from one to three groups and (C j -C 10 )alkoxy optionally substituted with from one to three fluoro groups; comprising reacting a compound of the formula wherein R 2 is defined as above, with a compound of the formula R^HO, wherein R 1 is defined as above, in the presence of a drying agent or using an apparatus designed to remove azeotropically the water generated, to produce an imine of the formula wherein R ] and R 2 are defined as above, and reacting the imine with a reducing agent. 8. A process according to claim 7, wherein the reducing agent is sodium triacetoxyborohydride. 9. A process according to claim 1, wherein said compound of formula IV is obtained by reducing a compound of the formula wherein R 2 is defined as for said formula IV. 10. A process according to claim 7, wherein said compound of formula IV is obtained by reducing a compound of the formula wherein R 2 is defined as for said formula IV. 11. A process according to claim 1, wherein said compound of formula IV is obtained by reacting a compound of the formula wherein R 2 is defined as for said formula IV, with hydroge in the presence of a metal containing catalyst. 12. A process according to claim 7, wherein sai compound of formula IV is obtained by treating a compound o the formula wherein R 2 is defined as for said formula IV, with hydrogen in the presence of a metal containing catalyst. 13. A process according to claim 11, wherein said metal containing catalyst is palladium on carbon. 14. A process according to claim 12, wherein said metal containing catalyst is palladium on carbon. 15. A process according to claim 11, wherein said solvent is a mixture of water and a lower alcohol containing hydrochloric acid. 16. A process according to claim 12, wherein said solvent is a mixture of water and a lower alcohol containing hydrochloric acid. 17. A process according to claim 1, wherein said compound of formula I formed thereby is a compound wherein R 1 and R 2 are the same or different and each of R 1 and R 2 is phenyl optionally substituted with one or more substituents independently selected from chlorine, fluorine, (C- t -Cg) alkyl optionally substituted with from one to three fluoro groups and (C,-C 6 ) alkoxy optionally substituted with from one t three fluoro groups. 18. A process according to claim 1, wherein sai compound of formula I formed thereby is a compound wherei R 1 is 2-methoxyphenyl and R 2 is phenyl. 19. A process according to claim 7, wherein sai compound of formula I formed thereby is a compound wherei R 1 and R 2 are the same or different and each of R 1 and R 2 i phenyl optionally substituted with one or more substituent independently selected from chlorine, fluorine, (Cj-C 6 ) alky optionally substituted with from one to three fluoro group and (C-,-C 6 ) alkoxy optionally substituted with from one t three fluoro groups. 20. A process according to claim 7, wherein sai compound of formula I formed thereby is a compound wherei R 1 is 2-methoxyphenyl and R 2 is phenyl. 21. A process according to claim 9, wherein th reduction is carried out using sodium in a boiling alcohol. 22. A process according to claim 9, wherein th reduction is carried out using lithium aluminu hydride/aluminum trichloride. 23. A process according to claim 9, wherein th reduction is an electrolytic reduction. 24. A process according to claim 9, wherein th reduction is carried out using hydrogen in the presence o a metal containing catalyst. 25. A process according to claim 24, wherein sai catalyst is platinum on carbon. 26. A process according to claim 1, wherein compoun of the formula IV is obtained by reacting a compound of th formula wherein R 2 is defined as for said formula IV, with lithium o sodium in ammonia, or with a formate salt in the presence o palladium, or with cyclohexene in the presence of palladium. 27. A process according to claim 1, wherein sai compound of formula I formed thereby is a compound wherei R 1 is 4,5-difluoro-2-methoxyphenyl and R 2 is phenyl. 28. A process according to claim 7, wherein sai compound of formula I formed thereby is a compound wherei R 1 is 4,5-difluoro-2-methoxyphenyl and R 2 is phenyl. 29. A process according to claim 1, wherein sai compound of formula I formed thereby is a compound wherei R 1 is 2-methoxy-5-trifluoromethylphenyl and R 2 is phenyl. 30. A process according to claim 7, wherein sai compound of formula I formed thereby is a compound wherei R 1 is 2-methoxy-5-trifluoromethylphenyl and R 2 is phenyl. 31. A process according to claim 1, wherein said compound of formula I formed thereby is a compound wherein R 1 is 2, -dimethoxyphenyl and R 2 is phenyl. 32. A process according to claim 7, wherein said compound of formula I formed thereby is a compound wherein R 1 is 2,4-dimethoxyphenyl and R 2 is phenyl. 33. A process according to claim 1, wherein said compound of formula I formed thereby is a compound wherein R 1 is 2,3-dimethoxyphenyl and R 2 is phenyl. 34. A process according to claim 7, wherein said compound of formula I formed thereby is a compound wherein R 1 is 2,3-dimethoxyphenyl and R 2 is phenyl. 35. A process according to claim 1, wherein said compound of formula I formed thereby is a compound wherein R 1 is ,l 5-chloro-2-methoxyphenyl" and R 2 is phenyl. 36. A process according to claim 7, wherein said compound of formula I formed thereby is a compound wherein R 1 is "5-chloro-2-methoxyphenyl" and R 2 is phenyl. 37. A process according to claim 1, wherein said compound of formula I formed thereby is a compound wherein R 1 is "3-chloro-2-methoxyphenyl" and R 2 is phenyl. 38. A process according to claim 7, wherein said compound of formula I formed thereby is a compound wherein R 1 is "3-chloro-2-methoxyphenyl" and R 2 is phenyl.

Inventors: ROSEN TERRY JAY, ROSEN, TERRY, JAY
Applicants: PFIZER, PFIZER INC.
Application year: 1992
Main classification: C07D409
IPC codes: A61K31, A61P3, A61P9, A61P17, A61P25, A61P29, A61P37, C07B53, C07C45, C07C47, C07C205, C07D211, C07D401, C07D405, C07D409