ATTRACTING AND INGESTION-STIMULATING AGENT FOR COCKROACH

Abstract: There are provided attracting and ingestion-stimulating agents for cockroach comprising as the active ingredient: (a) one or more compounds selected from the group of 1-amino-5,6,7,8-tetrahydronaphthalene, 2-amino-5,6,7,8-tetrahydronaphthalene, 2-aminomethyl-5,6,7,8-tetrahydronaphthalene and a salt thereof; and (b) one or more compounds selected from the group of p-n-butylphenol, p-n-amylphenol, 5,6,7,8-tetrahydro-1-naphthol and 5,6,7,8-tetrahydro-2-naphthol. The attracting and ingestion-stimulating agents for cockroach exhibit the very potent attracting and ingestion-stimulating activities in the known species of house cockroach, both male and female.

Description: DESCRIPTION Attracting and ingestion-stimulating agent for cockroach TECHNICAL FIELD The present invention relates to attracting and ingestion-stimulating agents for cockroaches. BACKGROUND ART Cockroach is one of the sanitarily harmful insects most widely known throughout the world. In Japan, as the house cockroach are known Periplaneata fuliginosa S. , P.japonica K. , P.americana L. , Blattella germanic L. , etc. In general, it is important for extermination of cockroach to possess both an attracting activity and an ingestion-stimulating activity. We have already provided several cockroach attracting and ingestion-stimulating agents which stimulataneously possess the activities both (USP 4,627,981; USP 4,911,907). Tetralol, naphthol and phenol compounds and Iristectoramines alchols, which are active ingredients of these cockroach attracting and ingestion-stimulating agents, are sufficiently active without any additives. However, they are often active against male P.americana L. only, and thus when applied to colonies of other species of cockroach or colonies of female cockroach only, they sometimes produce lower effects. DISCLOSURE OF INVENTION In order to provide more effectively attracting and ingestion-stimulating agents for cockroach than the prior art agents, we have investigated a composition comprising; (a)one or more compounds selected from the group of 1-amino-5,6,7,8-tetrahydronaphthalen , 2-amino-5,6,7,8- tetrahydronaphthalen , 2-aminomethyl-5,6,7,8-tetrahydro- naphthalene and a salt thereof ; and (b)one or more compounds selected from the group of p-n-butylphenol, p-n-amylphenol, 5,6,7,8-tetrahydro-l- naphtyhol and 5,6,7,8-tetrahydro-2-naρhthol show a hight attractant and ingestion-stimulating activity for cockroach. A more preferred agent for cockroach of the invention is concerned with a attracting and ingestion-stimulating agent for cockroach comprising as active ingredients a compound selected from the group consisting of l-amino-5,6,7,8- tetrahydronaphthalene, 2-amino-5,6,7,8-tetrahydronaphthalene, 2-aminomethyl-5,6,7,8-tetrahydronaphthalene and a salt thereof, and a compound selected from the group consisting of p-n-amylphenol, p-n-butylphenol, 5,6,7,8-tetrahydro-l- naphthol and 5,6,7,8-tetrahydro-2-naρhthol. All of the compound are known compounds. 1-Amino-5,6,7,8-tetrahydronaphthalene, 2-amino-5,6,7,8- tetrahydronaphthalene and 2-aminomethy1-5,6,7,8-tetrahydro- naphthalene are disclosed, for example, in the literature cited below. V.S. Misara et al. , J.Indian Chem. Soc. , 1985, 36, 803 S.W. Fenton et al. , J.Am.Chem. Soc, 1955, 77, 979 V.Grinsteins et al. , Lav.RSR Zinat.Akad.Veatis,Kim.Ser. , 1967, 7, 12 As the salt of the compounds, there can be mentioned, for example, hydrochloric acid salt, oxalic acid salt, citric acid salt, acetic acid salt, phosphoric acid salt, malonic acid salt, sulfric acid salt, tartaric acid salt, maleic acid salt, lactic acid salt and pyrophosphoric acid salt. 2-Aminomethyl-5,6,7,8-tetrahydronaphthalene is allow to stand in air to give a salt. The salt compound has a chemical structure as shown below; However, none of l-amino-5,6,7,8-tetrahydronaρhthalene -amino-5,6,7,8-tetrahydronaphthalene and 2-aminomethyl- 5,6,7,8-tetrahydronaphthalene are known for their cockroach attracting and ingestion-stimulating activities. p-n-Amyl- phenol, p-n-butylphenol, 5,6,7,8-tetrahydro-l-naphthol and 5,6,7,8-tetrahydro-2-naphthol are known for their cockroach attracting and ingestion-stimulating activities as described in USP 4,911,907 and USP 4,627,981. Attracting and ingestion-stimulating agents for cockroach according to the invention can be prepared, for example, by dissolving these compounds in an appropriate solvent (for example, a hydrophilic organic solvent such as acetone, ethanol, ethanol, tetrahydrofuran, ethylene glycol, diethylene glycol or N,N-dimethy1- formamide or lipophilic organic solvent such as benzene, chloroform, ether, methylene chloride or n-hexane) then ampergnating an appropriate carrier (for paper, cardboad, non-woven cloth, or flannel) with the solution and drying off the solvent to give attracting tapes or the like. The active-ingredient compounds according to the invention can also be used in such a form as granule, pill or tablet prepared by a conventional method using binder, excipient, lubricant, stabilizer and others as usually employed to give a bait. The bait form of the active-ingredient compounds according to the invention can be formulated together with an insecticidal ingredient. As the typical examples of the insecticidal ingredient, there can be mentioned, organophosphorous insecticides such as fenitorothion, pyridafenthion, chlropyrifos-methyl, pyrethroids such as allethrin, deltamethrin, phenothrin, resmethrin, cyphenothrin, permethrin, ethofenprox, fenvalerate, prallethrin, carbamates such as carbaryl, propoxur, methoxydiazon, insect growth regulator compounds such as dodecadienoate compounds, oxime-ether compounds, pyriyl compounds, benzoylphenyl compounds urea and other insecticides such as hydromethylnon, boric acid etc. If desired, the cockroach bait may contain one or more . conventional adjuvants. Examples of conventional adjuvants include pulverized grain, biscuit powder, sweetening, water, sugar, maltose excipient, excipients, stabirizer, surfactant, plant oil, dextrin and microcristallin cellulose. The active ingredient according to the invention show an attracting and ingestion-stimulating activity in a very small amount so that no particular care should be taken for amount to be used. It is preferable, for example, that a bait would contain the ingredient in a concentration of 0.01 % by weight or more of whole amount. The attracting and ingestion-stimulating action of the agents according to the invention will be described below in detail with reference to test examples. Test example 1 (Test material) A test material was prepared by the similar method in example 5. The test material contained 0.05% by weight of the compound in Table 1. Table 1 (Test insect) Groups of Periplaneata fuliginosa S. , P.japonica K. , P. australasiae L. , P.americana L. , Blattella germanic L. , Blatta orientalis L. each consisting of 100 adult male and female (1:1) cockroaches were prepared per one test materials. (Test methods) A group of the test insects was placed individually in a cage. After three days, the bait of the test material was examined for the degree of ingestion. The degree of ingestion of test material(a) - (k) were compared with test material (1). The experiment was repeated three times, and the average number of degree of ingestion was taken. (Test results) Results are shown in Table 2. Table 2 These values are expressed as compared with 1.0 of the valure of control sample(l) Test example 2 (Test materials) The same test procedure as in Test example 1 were employed except that two parts of hydromethylnone was formulated as an insecticide to give a test material (A) - (L). (Test insects) As test insects were employed 12 groups of Periplaneata fuliginosa L. , P.americana L. , Blattella germanic L. , Blatta orientalis L. consisting of 30 adult cockroaches and 30 larvae cockroaches per one test material. (Test method) 48 rooms, approximately 6 mats in size, were used. One week before initiation of the test each room was stocked with a group of different species of the cockroach, which was given food and water. The test material baits were set at five positions in each room. Effect of the attractants was evaluated on the basis of the number of dead cockroach. (Test results) The results are shown in Table 3. Table 3 LT90: days within which 90 % mortality BEST MODE FOR CARRYING OUT THE INVENTION Some examples of this invention will be explained as the following examples. However, this invention is not limited to these examples. Unless otherwise indicated, all parts are by weight. Example 1 A mixture of 75 parts powdery fish meal, 5 parts of maltose, 5 parts of L-arabinose, 5 parts of oleic acid, 10 parts of rice brain oil, 0.06 part of permethrin, 0.05 part of p-n-butylphenol and 0.03 part of 2-amino-5,6,7,8-tetrahydro- naphthalene was kneaded together with some water, and the mixture was formed into a small granular bait of the invention weighing about 0.7 g per granule. Example 2 150 parts of water-soluble starch, 150 parts of potato starch, 100 parts of boric acid 0.6 part of sodium benzoate, 0.2 part of dibutylhydroxytoluene, 0.03 part of 2-amino-5,6,7,8-tetrahydro- naphthalene, 0.1 part of 5,6,7,8- tetrahydro-1-naphthol and 599.5 parts of water were blended and formed into a cockroach bait of the invention weighing about 10 g per piece. Example 3 100 parts of wheat powders, 35 parts of water-soluble starch, 35 parts of starch, one part of methoprene, 0.06 part of sodium benzoate, 0.02 part of dibutylhydroxytoluene, 0.05 part of 5,6,7,8-tetrahydro-2-naphthol and 0.03 part of 2-amino-5,6,7,8- tetrahydronaphthalene hydrocarbonate were blended together with an appropriate amount of water and formed into a cockroach bait of the invention weighing about 5 g per piece. Example 4 100 parts of corn syrup, 30 parts of sorbitol, 14 parts of gelatin, 48 parts of water, 2 parts of pyriproxyfen, 0.06 part of sodium benzoate, 0.02 part of dibutylhydroxytoluene, p-n-butylphenol and 0.1 parts of 2-aminomethyl-5,6,7,8- tetrahydronaphthalene were blended and formed into a cockroach bait of the invention weighing about 10 g per piece. Example 5 40 parts of thick malt syrup, 45 parts of oats powder, 11 parts of macrogol, 0.5 part of cyphenothrin, one part of diflubenzurone, 0.06 part of sodium benzoate, 0.02 part of dibutylhydroxytoluene, 0.05 part of p-n-amylphenol and 2-amino-5,6,7,8-tetrahydro- naphthalene were blended and formed into a.cockroach bait of the invention weighing about 10 g per piece. Example 6 20 parts of brown sugar, 2 parts of corn oil, 2 parts of chryslis powder, 20 parts of biscuit powder, 50 parts dextrin, 0.06 part of sodium benzoate, 0.02 part of dibutylhydroxytoluene, 2 parts of hydramethylnone, 0.02 part of p-n-amylphenol and 0.03 part of 2-amino-5,6,7,8-tetrahydro- naphthalene were blended and formed into a cockroach bait of the invention weighing about 5 g per piece. Example 7 20 parts of powdery sugar, 10 parts of corn oil, 30 parts of sweet corn oil, 60 parts of crystalline cellulose, 2 parts of ethofenprox, 0.06 parts sodium benzoate, 0.02 part of dibutylhydroxytoluene, 0.02 part of p-n-amylphenol and 0. 03 part of 2-amino-5,6,7,8-tetrahydronaphthalene were blended and formed into a cockroach bait of the invention weighing about 5 g per piece. Example 8 15 parts of mineral oil, 2 parts of ammonium hydroxide, 2 parts of polyoxyethylene nonylphenyl ether, 0.5 part of carboxymethyl cellulose, 3.5 parts of potato starch, one part of propoxur, 0.5 part of fenoxycarb, 0.06 part of sodium benozate, 0.02 part of dibutylhydroxytoluene, 0.05 part of 5,6,7,8-tetrahydro-2-naρhthol and 0.03 part of 2-amino- 5,6,7,8-tetrahydronaphthalene were blended and formed into a cockroach bait of the invention weighing about 5 g per piece. Example 9 15 parts of white mineral oil, 1.5 parts of polyoxyethylene glycol dioleate, 2 parts of polyoxyethylene nonylphenyl ether, one part of hydroxyethyl cellulose, 0.5 part of xanthane gum, 5 parts of corn starch, 2 parts of chloropyrifosmethyl, 0.06 part of sodium benzoate, 0.02 part of 5,6,7,8-tetrahydro- 2-naphthol and 0.03 part of 2-amino-5,6,7,8-tetrahydro¬ naphthalene were blended and formed into a cockroach bait of the invention weighing about 5 g per piece. INDUSTRIAL APPLICABILITY The attracting and ingestion-stimulating agents of the invention not only exhibit a potent attracting and ingestion-stimulating activity on various species of cockroach but also are highly effective in cockroach extermination even when male and female cockroaches live together. This brings about low production cost and minimize the size of the preparation for easiness on use. The attracting and ingestion-stimulating component of the invention can also provide each of the cockroach controlling agents with fast acting effect.

Claims: CLAIMS 1. An attracting and ingestion-stimulating agent for cockroach comprising as the active ingredient; (a) one or more compounds selected from the group of l-amino-5,6, 7,8-tetrahydronaphthalene, 2-amino-5,6,7,8- tetrahydronaphthalen , 2-aminomethyl-5,6,7,8-tetrahydro¬ naphthalene and a salt thereof ; and (b) one or more compounds selected from the group of p-n- butylphenol, p-n-amylphenol, 5,6,7,8-tetrahydro-l-naphthol and 5,6,7, 8-tetrahydro-2-naphthol. 2. An attracting and ingestion-stimulating agent for cockroach comprising as the active ingredient one compound selected from the group consisting of 2-aminomethyl-5,6,7,8- tetrahydronaphthalene, 1-amino-5,6,7,8-tetrahydronaphthalene, 2-amino-5,6,7,8-tetrahydro-naphthalene and a salt thereof, and one compound selected from the group consisting of p-n-amylphenol, p-n-butyIpheno1, 5,6,7,8-tetrahydro-1-naphthol and 5,6,7,8-tetrahydro-2-naphthol. 3. An attracting and ingestion-stimulating agent to claim 1, wherein the cockroach is Periplaneata fuliginosa S. , P.japonica K. ' , P.americana L. , Blattella germanica L. , P.australasiae L. or Blatta orientalis L. 4. An attracting and ingestion-stimulating agent to claim 2, wherein the cockroach is Periplaneata fuliginosa L. , P.japonica K. , P.americana L. , Blattella germanica L. , P.australasiae L. , or Blatta orientalis L.

Inventors: NEMOTO MASAMI, OGINO KAZUMASA, SHIMAMURA HARUO, TOMISAWA KAZUYUKI, URUSHIZAKI FUMIO, NEMOTO, MASAMI, OGINO, KAZUMASA, SHIMAMURA, HARUO, TOMISAWA, KAZUYUKI, URUSHIZAKI, FUMIO
Applicants: TAISHO PHARMA CO LTD, TAISHO PHARMACEUTICAL CO., LTD.
Application year: 1992
Main classification: A01N33
IPC codes: A01N25, A01N33