Self-tanner cosmetic composition

Abstract: A cosmetic product and method for imparting a natural-appearing tan to skin is provided, the product being in the form of a multi-compartment dispenser. A first and second substance are stored in separate compartments of the dispenser, at least one of the substances including a silicone. Additionally, the first substance contains an alpha-hydroxy aldehyde such as dihydroxyacetone and the second substance contains at least one amino acid.

Description: The invention concerns a cosmetic composition which rapidly imparts a tan similar in color to a natural suntan onto the skin. Today there is a great health concern with natural tanning through sunlight. Ultraviolet radiation from the sun is considered to be a leading factor in causing skin cancer. Even if not lethal, ultraviolet radiation has been acknowledged as accelerating aging and wrinkling processes on the skin. Beyond health concerns, there are obvious practical reasons against natural tanning. Foremost is the reason that in many areas of the globe and during all but summertime, there is insufficient sunlight available to accomplish a natural tan. Based on the above considerations, there has been much interest in effectuating a tan through cosmetic means. Dihydroxyacetone (hereinafter known as DHA) has widely been utilized in cosmetics to accomplish self-tanning of the skin. In the J. Soc. Cosmet. Chem., 35 , pages 265-272 (August 1984), Bobin et al. studied the Maillard reaction of DHA with various amino acids found naturally in the hydrolipid film and first layers of the stratum corneum. The Maillard reaction method has commonly been utilized as an artificial tanning system since 1960. As a reference standard, Bobin et al. evaluated a mixture of amino acids thought normally to be found in the stratum corneum. This amino acid mixture included L-serine 24.7%, L-citrulline 16.4%, L-glycine 9.3%, L-alanine 8.9%, L-threonine 7.7%, L-aspartic Ac.5.5%, L-arginine 4%, L-histidine 3.6%, L-lysine 3.4%, L-tyrosine 3.2%, L-leucine 3%, L-valine 2.5%, L-glutamic Ac. 2.3%, L-phenylalanine 2.3%, L-proline 1.9% and L-ornithine 1.3%. Methionine sulfoxide was found to be the best amino acid or derivative in combination with DHA. It was suggested that these substances be separately formulated maintaining them apart in a compartmented dispensing device until use. Optical density results presented in the Bobin et al. article indicated that a full tanning color was not obtained until the passage of 72 hours. Even the use of isolated amino acids as opposed to the natural mixture did not improve the speed of coloration. Other studies on the Maillard reaction between DHA and amino acids have been reported in Agric. Biol. Chem. , 44 (7) , pages 1595-1599 (Kawashima et al.). Through this study it was determined that the rate of browning was maximum around a DHA-amino acid molar ratio of 1.5 when the total concentration of both reactants together was constant at 0.1 M. Lysine and glycine were found to have the highest browning activity. Another approach to the tanning problem is reported in Australian Patent 61950/90 to L'Oreal. The art had earlier appreciated that both DHA and 5,6-dihydroxy indole and certain of its derivatives would each independently cause coloration in the skin; the mechanisms were each believed to be different. The Australian patent teaches that a combination of these materials achieves a rapidly developed intense coloration much closer to the hue imparted by natural tanning than the colorations obtained with each of the compounds taken separately. Since DHA and indole are unstable in the presence of one another, the patent further suggested delivering these compounds from separate compartments of a multi-compartment kit. FR 2466492 discloses a method for colouring skin wherein the skin is treated with a solution of amino acid before, during or after application of an aldehyde. A variety of aldehydes that can be used are mentioned, amongst which di-hydrory-2,3-dibutanal-1,4. FR 1252400 describes a method for colouring skin by applying a solution of monosaccharide containing 2-4 carbon atoms, and letting it dry. The colour can be intensified or modified by incorporating nitrogen containing substances, e.g. amino acids. The use of amino acids in cosmetic compositions for colouring skin is also disclosed in EP 10483. Although there has been great progress in self-tanning compositions as noted above, considerable further progress is needed to increase speed of coloration and achieve a coloration even closer to a natural tan. For medical safety reasons, it is also preferred to avoid use of indoles. Accordingly, it is an object of the present invention to provide a method and composition for self-tanning having improved rates of coloration and imparting a more natural hue. In accordance with the present invention a cosmetic method is provided for parting a natural-appearing tan to skin comprising the steps of: (i) delivering from separate compartments of a multi-compartment dispenser a first and second substance, at least one of the substances including from 0.1 to 60% of a silicone, the first substance comprising: from 0.1 to 40% of a C 3 -C 24 alpha-hydroxy aldehyde; and an effective amount of a pharmaceutically acceptable vehicle for delivering the alpha-hydroxy aldehyde; and the second substance comprising: from 0.01 to 25% of at least one amino acid; and an effective amount of a pharmaceutically acceptable vehicle for delivering the at least one amino acid; and (ii) spreading on the skin a combination of the first and second substances delivered from the dispenser. The invention, in particular preferred aspects and embodiments thereof, will now be described in detail. Now it has been discovered that a very rapid self-tanning can be accomplished by delivering to the skin an alpha-hydroxy aldehyde, a silicone and one or more amino acids. The preferred amino acids are those of glycine, lysine, ornithine, tryptophan and mixtures thereof. Further it is important that the aldehyde and amino acids be stored in separate compartments, preferably within separate copartments of the same multi-compartment dispenser. A still further aspect of the invention has been the discovery that silicones can positively influence the intensity of the tan. A first substance or phase according to the invention will comprise a C 3 -C 24 alpha-hydroxy aldehyde in an amount from 0.1 to 40%, preferably from 1 to 20%, optimally between 2 and 15% by weight. The alpha-hydroxy aldehyde may be selected from dihydroxyacetone, glucose, xylose, fructose, reose, ribose, pentose, arabinose, allose, tallose, altrose, mannose, galactose, lactose, sucrose, erythrose, glyceraldehyde and combinations thereof. Most preferred is dihydroxyacetone. Amino acids are formulated in a second substance or phase. Glycine is the most preferred of the amino acids for purposes of this invention. Optionally, lysine and/or ornithine may be included along with the glycine. Especially effective is a combination of glycine, lysine and ornithine with the ratio of glycine to a combination of lycine and ornithine being from 50:1 to 1:2, optimally from 20:1 to 10:1; the ratio of lysine to ornithine can range from 10:1 to 1:10. Levels of each of the amino acids may range from 0.01 to 25%, preferably from 0.1 to 7%, optimally between 0.5 and 5% by weight. While dyes such as indole derivatives may be incorporated into either of the components or phases, for health and performance reasons, it may be desirable to formulate in the absence of indole derivatives. The weight ratio of the first to second substance may range from 10:1 to 1:10, preferably 2:1 to 1:2, optimally about 1:1. In a preferred embodiment, both the first and second phases have essentially identical components (or at least 90% by weight thereof identical) except for the aldehyde and amino acids being kept in separate phases. Importantly, compositions of the present invention will contain silicone oil. Silicone oils may be divided into the volatile and nonvolatile variety. Both types of silicone oils, but especially volatile silicone oils, unexpectedly have displayed a positive interaction with alpha-hydroxy aldehyde and amino acids to enhance the coloration. The term "volatile" as used herein refers to those materials which have a measurable vapor pressure at ambient temperature. Volatile silicone oils are preferably chosen from cyclic or linear polydimethylsiloxanes containing from 3 to 9, preferably from about 4 to about 5, silicon atoms. Linear volatile silicone materials generally have viscosities less than about 5 mm 2 /s (centistokes) at 25°C while cyclic materials typically have viscosities of less than about 10 mm 2 /s (centistokes). Examples of preferred volatile silicone oils useful herein include: Dow Corning 344, Dow Corning 345 and Dow Corning 200 (manufactured by Dow Corning Corp.); Silicone 7207 and Silicone 7158 (manufactured by the Union Carbide Corp.); SF 1202 (manufactured by General Electric); and SWS-03314 (manufactured by SWS Silicones, Inc.). The nonvolatile silicone oils useful in compositions of this invention are exemplified by the polyalkyl siloxanes, polyalkylaryl siloxanes and polyether siloxane copolymers. The essentially nonvolatile polyalkyl siloxanes useful herein include, for example, polydimethyl siloxanes with viscosities of from 5 to 100,000 mm 2 /s (centistokes) at 25°C. Among the preferred nonvolatile silicones useful in the present compositions are the polydimethyl siloxanes having viscosities from 10 to 400 mm 2 /s (centistokes) at 25°C. Such polyalkyl siloxanes include the Viscasil® series (sold by General Electric Company) and the Dow Corning 200 series (sold by Dow Corning Corporation). Polyalkylary siloxanes include poly(methylphenyl)siloxanes having viscosities of from 15 to 65 mm 2 /s (centistokes) at 25°C. These are available, for example, as SF 1075 methylphenyl fluid (sold by General Electric Company) and 556 Cosmetic Grade Fluid (sold by Dow Corning Corporation). Useful polyether siloxane copolymers include, for example, a polyoxyalkylene ether copolymer having a viscosity of 1200 to 1500 mm 2 /s (centistokes) at 25°C. Such a fluid is available as SF-1066 organosilicone surfactant (sold by General Electric Company). Cetyl dimethicone copolyol and cetyl dimethicone are especially preferred because these materials also function as emulsifiers and emollients. For purposes of the present invention, silicones may be present in amounts ranging from 0.1 up to 60%, preferably from 2 to 25%, optimally between 10 and 20% by weight. The relative weight ratio of silicone to total amino acid will range from 50:1 to 1:10, preferably from 20:1 to 1:8 optimally from 10:1 to 1:5. Synthetic esters are a further category of possible components utilized as emollients which nay be included within compositions of the invention. Among the ester emollients are: (1) Alkyl esters of fatty acids having 10 to 20 carbon atoms. Methyl, isopropyl, and butyl esters of fatty acids are useful herein. Examples include hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isopropyl isostearate, diisopropyl adipate, diisohexyl adipate, dihexyldecyl adipate, diisopropyl sebacate, lauryl lactate, myristyl lactate, and cetyl lactate. Particularly preferred are C 12 -C 15 alcohol benzoate esters. (2) Alkenyl esters of fatty acids having 10 to 20 carbon atoms. Examples thereof include oleyl myristate, oleyl stearate, and oleyl oleate. (3) Ether-esters such as fatty acid esters of ethoxylated fatty alcohols. (4) Polyhydric alcohol esters. Ethylene glycol mono and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol poly-fatty esters, ethoxylated glyceryl monostearate, 1,3-butylene glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty acid ester, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhydric alcohol esters. (5) Wax esters such as beeswax, spermaceti, myristyl myristate, stearyl stearate. (6) Sterols esters, of which cholesterol fatty acid esters are examples thereof. Humectants of the polyhydric alcohol-type may also be included in the compositions of this invention. The humectant aids in increasing the effectiveness of the emollient, reduces scaling, stimulates removal of built-up scale and improves skin feel. Typical polyhydric alcohols include polyalkylene glycols and more preferably alkylene polyols and their derivatives, including propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof. Propylene glycol is especially preferred for use in the amino acid phase. The amount of humectant may range anywhere from 0.1 to 20%, preferably between 0.5 and 5% by weight of the composition. The compositions of the invention can also include thickeners/viscosifiers in amounts up to about 10% by weight. As known to those skilled in the art, the precise amount of thickeners can vary depending upon the desired consistency and thickness of the composition. Especially preferred is trihydroxystearin. Other exemplary thickeners are xanthan gum, sodium carboxmethyl cellulose, hydroxyalkyl and alkyl celluloses, and cross-linked acrylic acid polymers such as those sold by B.F. Goodrich under the Carbopol trademark. Compositions of the present invention may also include emulsifiers or surfactants which may be of the nonionic, anionic, cationic or amphoteric type. Examples of satisfactory nonionic emulsifiers include fatty alcohols having 10 to 20 carbon atoms, fatty alcohols having 10 to 20 carbon atoms condensed with 2 to 20 moles of ethylene oxide or propylene oxide, alkyl phenols with 6 to 12 carbon atoms in the alkyl chain condensed with 2 to 20 moles of ethylene oxide, mono and di-fatty acid esters of ethylene glycol wherein the fatty acid moiety contains from 10 to 20 carbon atoms, fatty acid monoglyceride wherein the fatty acid moiety contains from 10 to 20 carbon atoms, polyoxyethylene sorbitol, polyoxyprocylene sorbitan, and hydrophilic wax esters. Amounts of the emulsifier may range anywhere from 0.1 to 20% by weight of the composition, preferably from 2 to 10% by weight. Water is a preferred carrier or the compositions of this invention. The amount of water may range from 10 to 95%, preferably from 30 to 80%, optimally between 40 and 60% by weight. Contemplated within the scope of this invention are water-in-oil emulsions in the form of lotions and creams. Oil advantageously is the continuous phase. The amounts of the oil to water phases may range from about 2:1 to 1:100, preferably about 1:1 to 1:10. Among other skin benefit agents which may be present in the compositions of this invention are fatty acids and alcohols having from 10 to 20 carbon atoms. Suitable examples of the fatty acids include pelargonic, lauric, myristic, palmitic, stearic, isostearic, hydroxystearic, oleic, linoleic, ricinoleic, arachidic, behenic, and erucic acids. Examples of satisfactory fatty alcohols include lauryl, myristyl, cetyl, hexadecyl, stearyl , isostearyl , hydroxystearyl, oleyl, ricinoleyl; behenyl, erucyl, and 2-octyl dodecanyl alcohols. These materials may be present in amounts anywhere from 0.1 to 20% by weight of the composition. Preservatives can desirably be incorporated into the cosmetic compositions of this invention to protect against the growth of potentially harmful microorganisms. While it is in the aqueous phase that microorganisms tend to grow, microorganisms can also reside in the oil phase. As such, preservatives which have solubility in both water and oil are preferably employed in the present compositions. Suitable traditional preservatives for compositions of this invention are alkyl esters of parahydroxy-benzoic acid. Other preservatives which have more recently come into use include hydantoin derivatives, proprionate salts, and a variety of quaternary ammonium compounds. Cosmetic chemists are familiar with appropriate preservatives and routinely choose them to satisfy the preservative challenge test and to provide product stability. Particularly preferred preservatives are methyl-paraben, imidazolidinyl urea, sodium dehydroxyacetate, propyl-paraben, trisodium ethylenediamine tetraacetate (EDTA) and benzyl alcohol. The preservative should be selected having regard for possible incompatiblities between the presevative and other ingredients. Preservatives are preferably employed in amounts ranging from 0.01% to 2% by weight of the composition. Minor adjunct ingredients nay also include fragrances, antifoam agents, opacifiers (e.g. titanium dioxide) and colorants, each in their effective amounts to accomplish their respective functions. Particularly useful minor ingredients are vitamin E linoleate, sodium hyaluronate and aloe vera gel, as well as other botanicals. A sunscreen agent is a further desirable ingredient of the compositions of this invention. This ingredient is preferably incorporated into the second component or oily phase. The term "sunscreen agent" as used herein defines ultraviolet ray-blocking compounds exhibiting absorption within the wavelength region between 290 and 400 nm. Sunscreens may be classified into five groups based upon their chemical structure: para-amino benzoates; salicylates; cinnamates; benzophenones; and miscellaneous chemicals including menthyl anthralinate and digalloyl trioleate. Inorganic sunscreens may also be used including titanium dioxide, zinc oxide, iron oxide and polymer particles such as those of polyethylene and polyamides. Preferred materials include p-aminobenzoic acid and its derivatives, anthralinates; salicylates; cinnamates; courmarin derivatives; azoles; and tannic acid and its derivatives. Among FDA approved sunscreens are those listed in the table below. UV-A Absorbers Approved % Oxybenzone, also known as 2-hydroxy-4-methoxy benzophenone, and benzophenone-3, available as Uvinul® M-40 and Gafsorb® 2H4M 2-6 Dioxybenzone, also known as 2,2 dihydroxy-4-methoxy benzophenone, and benzophenone-8 3 Sulibenzone, also known as 2-hydroxy-4-methoxy benzophenone-5-sulphonic acid, and benzophenone-4, available as Uvinul® MS-40 and Gafsorb® 2H4MS 5-10 Menthyl anthralinate, also known as menthyl-o-aminobenzoate 3.5-5 UV-B Absorbers Approved % p-Amino benzoic acid, also known as PABA 5-15 Amyl dimethyl PABA (NA), also known as amyl-p-dimethyl ammonium benzoate, available as Padimate A® 1-5 2-Ethoxy ethyl p-methoxy cinnamate (NA), available as Cinoxate® and Givtan-F® 1-3 Diethanolamine p-ethoxy cinnamate, also known as DEA methoxy cinnamate, available as Parsol-Hydro® 8-10 Digalloyl trioleate (NA), a component of Solprotex I® 2-5 Ethyl-4-bis (hydroxypropyl) aminobenzoate, also known as ethyl dihydroxy propyl PABA, available as Amerscreen P® 1-5 2-Ethyl hexyl-2-cyano-3,3 diphenyl acrylate, also known as octocrylene and available as Uvinul® N-539 7-10 Ethyl hexyl p-methoxy cinnamate, also known as octyl methoxycinnamate available as Parsol MCX® 2-7.5 2-Ethyl hexyl salicylate, also known as octyl salicylate 3-5 Glyceryl aminobenzoate, also known as glyceryl p-aminobenzoate and glyceryl PABA, available as Escalol® 106 2-3 Homomenthyl salicylate, also known as 3,3,5-trimethylcyclohexyl salicylate 4-15 Lawsone with dihydroxyacetone (NA) 0.25 with 33 Octyl dimethyl PABA, also known as 2-ethyl hexyl p-dimethyl p-aminobenzoate, and 2-ethyl hexyl dimethyl PABA, available as Padimate O® and Escalol® 507 1.4-8 2-Phenyl benzimidazole 5-sulphoic acid 1.4 Triethanolamine salicylate 5-12 Physical Screens Approved % Red Petrolatum 30-100 Titanium dioxide 2-25 According to the present invention there is required a multi-compartment dispenser. Illustrative of such dispensers are those described in U.S. Patents 1,639,699 and 1,699,532, each to Hopkins, describing double collapsible tubes. Separation of reactive components is also described in U.S. Patent 4,211,341 (Weyn). Other examples are those found in U.S. Patent 4,487,757 (Kiozpeoplou) in Fig. 1 as well as U.S. Patent 4,528,180, U.S Patent 4,687,663 and U.S. Patent 4,849,213, each of which is to Schaeffer. Most preferred for purposes of this invention is a dual container tube described in copending U.S. Patent Application Serial No. 07/686,730 filed April 17, 1991, subsequently published as US 5 137 178. Each of a pair of compartments in the dual container described therein is flexible walled and received in a relatively rigid receptacle having a left and right wall positioned on opposite sides of the receptacle. Within each of the latter walls are a respective window through which a button protrudes that, when squeezed, compresses the respective compartments and forces a composition to exit therefrom. The term "multi-compartment" also includes separation by means of encapsulation. Ihus, cosmetic compositions of this invention, such as water-in-oil emulsions, may contain microcapsules surrounding an amino acid core, an alpha-hydroxy aldehyde core or both types or microrocapsules, the capsule walls serving as a separating compartment. Release of amino acids and/or aldehydes occurs by crushing of the capsule walls as the product is rubbed onto the skin. The following examples will more fully illustrate the embodiments of this invention. All parts, percentages and proportions referred to herein and in the appended claims are by weight unless otherwise indicated. EXAMPLE 1 In vitro studies were conducted for a self-tanning two-phase system. Color development was measured by spectrophotometry with focus upon the wavelength at 420 nm. Reaction between the first and second substances containing DHA and an amino acid, respectively, were conducted at 37°C utilizing 0.01 M amino acid and 2 M DHA aqueous solutions. Each solution was buffered with 39% sodium dihydrogen phosphate hydrate and 61% disodium hydrogen phosphate heptahydrate. These solutions were formulated to 100 ml each. A Perkin-Elmer 559UV-VIS Spectrophotometer was employed to measure the absorbance at 420 nm color evolution as a function of time. Results are recorded in Table I. From Table I it is evident that the fastest reacting amino acid is tryptophan. Other amino acids providing good color intensity were glycine, lysine and ornithine. EXAMPLE 2 A first and second phase formulation according to the present invention was prepared with each phase being stored in a separate compartment in a dual-compartment dispenser. Table II lists the components of each phase. DHA Phase Ingredient Wt. % Dihydroxy Acetone 14.00 Cyclomethicone 10.00 Octyl Methoxycinnamate 7.50 Benzophenone-3 2.00 Polyglyceryl Ricinoleate 2.00 Cetyl Dimethicone Copolyol 1.00 Sodium Chloride 1.00 Preservatives 0.40 Deionized Water Balance Amino Acid Phase Ingredient Wt. % Cyclomethicone 10.00 Octyl Methoxycinnamate 7.50 Glycine 3.40 Benzophenone-3 2.00 Polyglyceryl Ricinoleate 2.00 Cetyl Dimethicone Copolyol 1.00 Sodium Chloride 1.00 Preservatives 0.40 Lysine Hydrochloride 0.10 Ornithine Hydrochloride 0.10 Deionized Water Balance The formulation according to Table II is dispensed by extruding equal amounts of the DHA and amino acid phases from their respective compartments onto human skin. These phases are then intimately mixed together and rubbed into the skin. Within only a few hours, an almost natural tan arises. EXAMPLE 3 This Example illustrates the affect of the relative weight ratio between cyclomethicone (silicone) and the total amount of amino acids. Table III correlates the ratios with intensity and color change. Intensity is indicated by the "+" symbol, the greatest intensity being symbolized as "+++". Observations were taken at 3 hours and at 24 hours. Seven panelists participated in these trials. Each of the three test creams were simultaneously applied to the forearm of the panelist with a dosage of 3.92 mg/cm 2 . The panelists were allowed to shower between the 3 and 24 hour observations. Table IV identifies the formulations used in Table III. Panelist No. Ratio of Silicone : Amino Acids 3 Hours 24 Hours 10:1 1:1 1:10 10:1 1:1 1:10 1 +++/red ++/sl.red +/yellow +++/red +/red ++/yellow 2 +++/red ++/red +/yellow +++/red +/red ++/yellow 3 +++/red ++/red +++/yellow +++/red ++/red +/yellow 4 +++/red ++/red +/yellow +++/red +/red ++/yellow 5 +++/red ++/red +/yellow +++/red ++/red +/yellow 6 +++/red ++/red +/yellow +++/red ++/red +/yellow 7 +++/red ++/red ++/yellow +++/red ++/red ++/yellow Ingredient 10:1 Ratio 1:1 Ratio 1:10 Ratio A A' B B' C C' Deionized water 66.9 56.5 83.1 72.7 84.2 74.32 Glycine 3.4 - 3.4 - 3.4 - Lysine·HCl 0.1 - 0.1 - 0.1 - Ornithine·HCl 0.1 - 0.1 - 0.1 - Sodium chloride 1.0 1.0 1.0 1.0 1.0 1.0 DHA - 14.0 - 14.0 - 14.0 Cyclomethicone 18.0 18.0 1.8 1.8 0.18 0.18 Parsol MCX 7.5 7.5 7.5 7.5 7.5 7.5 Octyl stearate 7.5 7.5 7.5 7.5 7.5 7.5 Polyglyceryl ricinoleoate 2.0 2.0 2.0 2.0 2.0 2.0 Cetyl dimethicone copolyol 1.0 1.0 1.0 1.0 1.0 1.0 A natural tan is expected to have a reddish rather than a yellow hue. Based on the results listed in Table III, ratios of 10:1 and 1:1 produce the nest (i.e. reddish) tan color and provided deepest tan intensity. Where the silicone to amino acid ratio was 1:10, color intensity was generally less and uniformly yellow in hue. EXAMPLE 4 Experiments hereunder illustrate the effects of emulsion-type on the intensity and color change. A water-in-oil emulsion was compared to an oil-in-water emulsion as vehicles for the DHA and amino acids. Conditions of the test were similar to that discussed under Example 3. Table V details the results of the experiments. Table VI provides the formulations utilized for these tests. Panelist No. 3 Hours 24 Hours W/O O/W W/O O/W 1 +++/redder +++/yellower +++/redder +++/yellower 2 +++/redder +/yellower +++/redder +(streaky)/yellower 3 +++/sl. redder +++/sl.yellower +++/redder +++(streaky)/yellower 4 +++/redder +(streaky)/yellower +++/redder +(streaky)/yellower 5 +++/sl. redder +++/sl. yellower +++/sl. redder +++/sl. yellower 6 +++/redder +/yellower +++/sl. redder +++/sl. yellower 7 +++/redder +/yellower +++/redder +/yellower Ingredient Water-in-oil Emulsions Oil-in-Water Emulsions A A' B B' Deionized water 74.9 64.5 74.9 64.5 Sodium chloride 1.0 1.0 1.0 1.0 Glycine 3.4 - 3.4 - Lysine·HCl 0.1 - 0.1 - Ornithine·HCl 0.1 - 0.1 - DHA - 14.0 - 14.0 Cyclomethicone 10.0 10.0 10.0 10.0 Parsol MCX 7.5 7.5 7.5 7.5 Ceteareth-2 - - 1.0 1.0 Ceteareth-2l - - 2.0 2.0 Polyglyceryl ricinoleate 2.0 2.0 - - Cetyl dimethicone copolyol 1.0 1.0 - - Evident from Table V is that generally the water-in-oil emulsion performed better delivering a more even, redder and somewhat deeper tan color. EXAMPLE 5 This Example illustrates the affects of varying DHA and amino acid levels. Conditions for the test were identical to those outlined under Example 3. Table VII details the results of these experiments. Wt.% DHA Wt. % Amino Acids Ratio DHA:AA 1 Hour (Color Intensity) 5.0 0 + 5.0 1.0 5:1 + 5.0 6.0 1:1.2 +++ 12.0 3.6 3.3:1 +++ 14.0 4.6 3.0:1 +++ 14.0 3.6 3.8:1 +++ 14.0 2.6 5.3:1 +++ 15.0 4.0 3.7:1 +++ 16.0 6.0 2.6:1 +++ From results of Table VII, it is seen that excellent initial color intensity was achieved for a range of concentrations even after only one hour subsequent to treatment.

Claims: A cosmetic method for imparting a natural-appearing tan to skin comprising the steps of: (i) delivering from separate compartments of a multi-compartment dispenser a first and second substance, at least one of the substances including from 0.1 to 60% of a silicone, the first substance comprising: from 0.1 to 40% of a C 3 -C 24 alpha-hydroxy aldehyde; and an effective amount of a pharmaceutically acceptable vehicle for delivering the alpha-hydroxy aldehyde; the second substance comprising: from 0.01 to 25% of at least one amino acid; and an effective amount of a pharmaceutically acceptable vehicle for delivering the at least one amino acid; and (ii) spreading on the skin a combination of the first and second substances delivered from the dispenser. A method according to claim 1 wherein the alpha-hydroxy aldehyde is selected from the group consisting of dihydroxyacetone, glucose, xylose, fructose, reose, ribose, pentose, arabinose, allose, tallose, altrose, mannose, galactose, lactose, sucrose, erythrose, glyceraldehyde and combinations thereof. A method according to claim 1 or claim 2 wherein the amino acid is selected from the group consisting of glycine, lysine, ornithine, tryptophan, salts and mixtures thereof. A method according to any one of claims 1 to 3 wherein the silicone is a cyclic or linear polydimethylsiloxane containing from 3 to 9 silicon atoms. A method according to any preceeding claim wherein the silicone and total amino acids present are in a relative weight ratio of from 50:1 to 1:10. A method according to claim 5 wherein the relative weight ratio ranges from 10:1 to 1:5. A method according to any preceeding claim wherein the first and second substances are water-in-oil emulsions. A method according to any preceding claim wherein at least one of the substances is encapsulated within a microcapsule, the microcapsule functioning as one of the multi-compartments. A cosmetic product which is a multi-compartment dispenser wherein a first and second substance are stored in separate compartments thereof, at least one of the substances including from 0.1 to 60% of a silicone, the first substance comprising: from 0.1 to 40% of a C 3 -C 24 alpha-hydroxy aldehyde; and an effective amount of a pharmaceutically acceptable vehicle for supporting the alpha-hydroxy aldehyde; and the second substance comprising: from 0.01 to 25% of at least one amino acid; and an effective amount of a pharmaceutically acceptable vehicle for delivering at least one amino acid. A cosmetic product according to claim 9 wherein the alpha-hydroxy aldehyde is selected from the group consisting of dihydroxyacetone, glucose, xylose, fructose, reose, ribose, pentose, arabinose, allose, tallose, altrose, mannose, galactose, lactose, sucrose, erythrose, glyceraldehyde and combinations thereof. A cosmetic product according to claim 9 or claim 10 wherein the amino acid is selected from the group consisting of glycine, lysine, ornithine, tryptophan, salts and mixtures thereof. A cosmetic product according to any one of claims 9 to 11 wherein the silicone is a cyclic or linear polydimethylsiloxane containing from 3 to 9 silicon atoms. A cosmetic product according to any one of claims 9 to 12 wherein the silicone and total amino aces present are in a relative weight ratio of from 50:1 to 1:10. A cosmetic product according to claim 13 wherein the relative weight ratio ranges from 10:1 to 1:5. A cosmetic product according to any one of claims 9 to 14 wherein the first and second substances are water-in-oil emulsions. A cosmetic product according to any one of claims 9 to 15 wherein at least one of the substances is encapsulated within a microcapsule, the microcapsule functioning as one of the multi-compartments.

Inventors: DOBKOWSKI BRIAN JOHN, SUARES ALAN JOSEPH, DOBKOWSKI, BRIAN JOHN, SUARES, ALAN JOSEPH
Applicants: UNILEVER NV, UNILEVER PLC, UNILEVER N.V.
Application year: 1992
Main classification: A61K7
IPC codes: A61K8, A61Q17, C08L83, A61Q19