Variable rate pacemaker having upper rate limit governor based on hemodynamic performance

Abstract: A rate adaptive pacemaker of the type having a variable rate cardiac stimulating pulse generator (32) and a sensor for monitoring some physiologic parameter (18) whereby the pulse generator stimulating rate can be adjusted to meet physiologic demand is further provided with a hemodynamic sensor (34) which is operative to provide an output signal representing the pumping performance of the heart in response to the pacing stimulation. The signal from the hemodynamic sensor (34) is processed and then used in an algorithm to determine whether further rate increase should be permitted based upon whether the rate increase would be accompanied by a further increase in cardiac output, a plateau or a decrease in cardiac output. Hence, the adaptive rate pacemaker is provided with a real-time, hemodynamic maximum pacing rate instead of a pre-programmed, fixed, maximum rate.

Description: BACKGROUND OF THE INVENTION I. Field of the Invention: This invention relates generally to cardiac pacing apparatus, and more particularly to a variable rate pacemaker which incorporates a sensor for monitoring hemodynamic performance and for establishing the pacing rate as determined by the hemodynamic performance of the heart. II. Discussion of the Prior Art: There exists a class of cardiac pacemakers known as variable rate or rate adaptive pacemakers which include a first sensor for determining metabolic demand and means for adjusting the pacing rate or escape interval of the stimulating pulse generator based upon that metabolic demand. For example, the Anderson et al. Patent 4,428,378 discloses a rate adaptive pacer having an activity sensor which produces an electrical signal related to the level of motion or activity of the patient in whom the pacemaker is implanted. The activity signal is signal-processed and applied to a voltage-controlled oscillator for adjusting the rate at which electrical stimulating pulses are produced. The pacemaker has a predetermined, programmed lower stimulating pulse rate, and sensed activity results in a pulse rate increase from that lower rate threshold up to a predetermined, programmed maximum rate. There are a variety of other rate adaptive pacers in which parameters other than motion or activity are sensed. For example, the Begemann et al. Patent 4,972,834 describes such a pacemaker in which the QT interval of the ECG cycle is measured and because that interval varies with physiologic demand, it is used to adjust the pacing rate or escape interval of a stimulating pulse generator such that the rate varies with physiologic demand. Again, a programmed lower rate limit and upper rate limit is provided to assure that the patient is not paced at a rate which may prove harmful. The upper rate limit is, however, established by the physician and programmed into the pacemaker as a fixed limit. Other parameters that have been sensed and used to control pacing rate have included right ventricular systolic pressure (Koning et al. Patent 4,566,456); blood pH (Alcidi Patent 4,009,721); blood oxygen saturation (Wirtzfeld et al. Patent 4,202,339); respiration rate (Krasner Patent 3,593,718); partial pressure of carbon dioxide in the blood, pCO₂, (Koning et al. Patent 4,716,887); blood temperature (Cook et al. Patent 4,436,092); and pre-ejection period (Chirife Patent 4,719,921). The foregoing list of prior art patents relating to rate adaptive pacemakers is merely illustrative in that other patents have been granted. Hence, the above listing is not intended to be exhaustive. Typical adaptive rate pacemakers, such as those described in the aforementioned patents, are primarily operated so as to increase the pacing rate in responses to a change in the parameter being sensed. However, if the pacing rate is allowed to increase inappropriately in a pathological heart, inefficiencies may result in the heart's pumping function, resulting in hemodynamic instability. That is to say, the patient may become uncomfortable, experience shortness of breath and cease exercising. Thus, it is desirable to establish a match between the pacing rate and the optimal pump function in that exercise tolerance would improve at both maximal and submaximal levels of effort. Prior art adaptive rate pacemakers typically involve the simple conversion of a sensor value to a paced rate. The sensor index may be of various technologies, all as pointed out above. These technologies include piezoelectric motion or activity sensing, accelerometer-based activity, transthoracic impedance measures, right ventricular impedance measures and others. A study of prior art cardiac pacers also reveals that considerable attention has been paid to the establishment of rate response curves used to convert a sensor signal to a pacing rate control signal between the lower rate limits and maximum sensor rate. A combination of sensors may be used simultaneously or in concert for developing the desired rate response curve. For example, activity may be used to initiate rate response and a proportional control may be provided by sensing temperature or minute ventilation indices once the pacing rate has exceeded some predetermined value above the base or at-rest value. If the heart is paced too fast, it may not be able to adequately improve cardiac output. In a normal heart at excessively high rates, the cardiac output decreases as the rate increases. This induced hemodynamic instability usually does not occur until there are higher paced rates, i.e., in excess of 150-200 bpm. However, in the pathologic heart, less cardiac reserve is present. Hence, if paced at too high a rate, severe shortness of breath and hemodynamic instability may result. US-A-4867160 discloses a pacemaker that monitors hemodynamic performance during pacing and alters the pacing rate to a level that is intended (on the basis of a predetermined operating curve) to give maximum CO (cardiac output) at the prevailing level of patient activity. In the preferred embodiment, the curve is predetermined on the basis of stroke volume and heart rate at maximum patient activity. The present invention relates to an improved pacemaker as set out in claim 1, that monitors the hemodynamic performance of the heart. The precharacterising part of claim 1 is based on US-A-4867160, and the distinguishing features of the present invention are set out in the characterising part of claim 1. The hemodynamic performance may be assessed using, for example, intracardiac impedance plethysmography to measure cardiac output while an activity sensor is employed to sense physiologic demand and to alter the pacing rate. DESCRIPTION OF THE DRAWINGS The foregoing features, objects and advantages of the invention will become apparent to those skilled in the art from the following detailed description of the preferred embodiment, especially when considered in conjunction with the accompanying drawings in which: Figure 1 is a block diagram of a prior art adaptive rate pacemaker; Figure 2 is a graph showing the manner in which stroke volume and cardiac output vary with pace rate; Figure 3 is a block diagram representation of an adaptive rate pacemaker incorporating the hemodynamically determined maximum pacing rate; and Figure 4 is a graph illustrating the hemodynamically determined upper rate limit and the rate adaptive pacemaker of Figure 3. DESCRIPTION OF THE PREFERRED EMBODIMENT Before describing the rate adaptive pacemaker of the present invention, it is believed essential to a full and complete understanding thereof to first appreciate the features of prior art devices and, in this regard, reference is made to Figure 1 which illustrates diagrammatically the functional compliments of such a device. It is seen to include a variable rate pacemaker pulse generator 10 capable of producing cardiac stimulating pulses on a lead 12 which is appropriately positioned on or in the heart 14. If the pulse generator 10 is of the demand type, a sense amplifier 16 would typically be used to detect normal cardiac depolarization signals (R-waves) and apply a reset to the timing circuits within the variable rate pacemaker pulse generator 10 to thereby preclude the generation of electrical stimulating pulses on lead 12 when the heart is beating in a normal fashion at a prescribed lower rate threshold. Also forming a part of the prior art rate adaptive pacemaker is a rate response sensor 18 which, as already indicated, may take any number of forms depending upon the physiologic parameter to be monitored. For example, the sensor 18 may comprise a piezoelectric activity sensor, an accelerometer, a blood temperature sensor, a sensor for measuring rate and/or depth of respiration, or a sensor for monitoring a particular interval in the QRS complex, all as is disclosed in the prior art. In fact, the rate response sensor 18 may include plural sensors of different types to create a composite output which is piece-wise so as to create an electric signal on line 20 indicative of physiologic demand. For example, between a lower limit and an intermediate rate value, activity may be sensed, and between that intermediate rate and a higher rate, blood temperature may be sensed. The electrical signal on line 20 is then applied to an index-to-rate convertor 22 for creating an electric signal on line 24 which varies in a prescribed way with changes in the output from the rate's responsive sensor 18. This control signal on line 24 is then applied to the timing circuitry of the variable rate pacemaker pulse generator 10 to thereby vary the rate at which cardiac stimulating pulses are produced on lead 12. Typically, the variable rate pacemaker pulse generator 10 will incorporate within it a lower rate limit and a maximum limit to place bounds on the stimulation pulse rate. The index-to-rate converter 22 operates to define the slope of the curve when the output signal therefrom is plotted as a function of the input signal on line 20 from the rate responsive sensor 18. Referring next to Figure 2, there is shown graphically a plot of both stroke volume and cardiac output as a function of the rate at which the heart is being paced. As the pacing rate increases, the stroke volume of the heart is seen to decrease. Cardiac output is the product of stroke volume and heart rate ( CO=SVxHR ). It is seen to increase until a point is reached at which the stroke volume has fallen to such a low level that even though the paced rate increases, the cardiac output increases cannot be sustained. The use of a pacing rate higher than .26 on the cardiac output curve provides only a minimal increase in cardiac output. Hence, with a constant level of exercise, it would be inappropriate to choose a pacing rate greater than that associated with this point. It should also be appreciated that a heart failure patient has low cardiac reserve, i.e., a diminished capacity of the heart to increase cardiac output and raise blood pressure above basal to meet body requirements. Hence, different levels of activity for such a patient will typically be inappropriate. If curve 28 is considered to be a plot of an individual with a healthy heart, the dotted line curve 30 may be representative of a patient with some degree of heart failure. While the maximum pacing rate is typically established by the cardiologist during the course of an exercise regimen, in accordance with prior art systems, that maximum rate is a fired programmed value that could be inappropriate for higher levels of exercise and differing physiologic states. In accordance with the pacemaker of the present invention a hemodynamic sensor is added to the adaptive rate pacemaker which is operative to provide an output signal representing the pumping performance of the heart in response to the pacing stimulation. This signal is processed and then used in an algorithm to determine whether further rate increase should be permitted based upon whether the rate increase would be accompanied by a further increase in cardiac output, a plateau or a decrease in cardiac output. This provides a real-time, hemodynamic maximum pacing rate as contrasted to a pre-programmed fixed value. Referring to Figure 3, there is illustrated a block diagram of a rate adaptive pacer incorporating the hemodynamic maximum pacing rate aspects. It includes the usual rate response sensor 18, an index-to-rate converter 22 resulting in a signal on line 24 which, if applied to the pacing circuit 32 will result in a change in the frequency with which stimulating pulses are applied to the heart 14. As already discussed, the rate control signal on line 24 is directly proportional to the change in physiologic demand sensed by the rate response sensor 18. In addition to the rate response sensor 18, the rate adaptive pacemaker of the present invention also includes a hemodynamic monitoring sensor 34 which may comprise an impedance measuring system of the type described in the Salo et al. Patent 4,686,987. Further information concerning a pacemaker incorporating an impedance sensing system is the Citak et al. Patent US-A-4,773,401 assigned to applicants' assignee. Alternatively, the hemodynamic monitoring sensor 34 may measure right ventricular pressure or any other parameter indicative of the pumping performance of the heart. If a given sensor is used for the hemodynamic monitoring sensor 34, the rate response sensor 18 might well comprise the same impedance sensing sensor, a piezo-electric activity sensor, a blood temperature sensor or a respiration rate sensor although the algorithmic treatment of the sensor output may be different. The output from the hemodynamic monitoring sensor 34 is likewise applied to an index-to-rate converter 36 operative to establish the transfer function between the paced rate and the hemodynamic parameter being sensed. As is shown by block 36 in Figure 3, for purposes of illustration, it is cardiac output that is the hemodynamic parameter being sensed by unit 34 and the device 36 produces a signal on line 38 relating cardiac output to the stimulating pulse rate (paced rate). This signal along with the one on line 24 from the index-to-rate converter 22 is applied to decision logic 40 which functions to determine whether hemodynamic stability is confirmed. The algorithm implementing the decision logic 40 determines whether the current cardiac output indicated by the signal on line 38 is higher or the same as it was for the previously established pacing rate and, if so, the pacing circuit 32 is allowed to again have its rate increased in accordance with the signal on line 24. On the other hand, if the decision logic 40 determines that the cardiac output indicated by the signal on line 38 is lower than the previously established value, then the signal on line 24 is prohibited from further increasing the stimulating pulse frequency of the pacing circuit 32. Referring to Figure 4, there is graphically illustrated the rate response of the pacemaker of the present invention with changes in the level of exercise or other physiologic parameter. While the pacemaker may have incorporated in it a programmed maximum sensor rate as indicated by dotted line 46 and a programmed lower rate limit 48, the hemodynamic upper rate limit governs the pacing rate at any level between these two limits when the decision logic 40 determines that cardiac output is attenuated with any further pacing rate increase. For purposes of discussion, it has been assumed that hemodynamic upper rate sensor 34 uses right ventricular impedance based stroke volume measurements to calculate cardiac output. However, it is to be understood that any hemodynamic sensor can be used, such as pressure, flow, volume, and/or timing components, such as pre-ejection interval, which may be appropriate to monitor cardiac performance. Further, the described embodiment presumed the use of conventional rate control using an activity based system, such as a piezo-electric crystal or an accelerometer. This invention is also not limited to that particular technology, and may include any sensor or multiplicity of sensors for driving the paced rate between a lower rate and an maximum rate. While it has been assumed that the hemodynamic stability confirmation is based upon a test as to whether an incremental increase in stimulating pulse rate is accompanied by a corresponding decrease in cardiac output, it is also possible, using a differentiating circuit to determine the rate of change of cardiac output with pacing rate and then inhibit further rate increases when the rate of change decreases with an incremental change in the pacing rate. By using the present invention, the pacemaker of the present invention maximizes cardiac output at any given level of exercise while minimizing the symptomatic effect of pump malfunction resulting in exercise intolerance. Those skilled in the art will appreciate that the present invention may be implemented in hardware in a variety of fashions. For example, a pacemaker incorporating the hemodynamic upper rate limit principle can be implemented in analog circuitry or, conversely, the adaptive rate pacemaker may be implemented utilizing a programmable digital controller.

Claims: A rate adaptive pacemaker including a variable rate pulse generating means (32) for producing cardiac stimulating pulses at a first pulse rate, second means (34) for determining hemodynamic performance of the heart in response to said stimulating pulses, third means (40) responsive to the determination by said second means (34) for determining whether or not the pulse rate should be altered to a second rate and if so, causing the pulse generating means to produce pulses at the second rate; and fourth means (18) for sensing physiologic demand, characterised in that the fourth means (18) is operable to sense change in physiological demand and is operatively connected with fifth means (22) responsive to change in physiological demand sensed by the fourth means (18) to produce a control signal as a function of the sensed change, the control signal corresponding to the second pulse rate, the third means (40) being operatively connected with the fifth means (22) to receive the control signal and cause the pulse generating means to generate pulses at the second rate, in accordance with the control signal, when the third means determines that the pulse rate should be altered to the second rate. The rate adaptive pacemaker as in Claim 1 wherein said second means (34) includes means for measuring changes in right ventricular impedance. The rate adaptive pacemaker as in Claim 1 wherein said second means (34) senses stroke volume. The rate adaptive pacemaker as in Claim 1 wherein said second means (34) measures cardiac output. The rate adaptive pacemaker as in Claim 1 wherein said second means (34) includes means for measuring arterial pressures. The rate adaptive pacemaker as in Claim 1 wherein said second means (34) includes means for measuring the pre-ejection interval of the cardiac cycle. The rate adaptive pacemaker as in Claim 1 wherein said third means determines that the pulse rate should not be altered when the hemodynamic performance determined by the second means (34) indicates that such a rate change would degrade hemodynamic performance of the heart. The rate adaptive pacemaker as in Claim 4 wherein the second rate is greater than the first rate and said third means (40) determines that the pulse rate should not be increased when the hemodynamic performance determined by the second means (34) indicates that such a rate increase would result in a decrease in cardiac output. The rate adaptive pacemaker as in Claim 8 wherein said third means (40) determines that the pulse rate should not be increased when the rate of change of cardiac output with respect to stimulation pulse rate drops below a predetermined slope value. The rate adaptive pacemaker of any preceding claim wherein the second rate is greater than the first rate and the third means is operable to limit the upper pulse rate at which said stimulating pulses are produced. The rate adaptive pacemaker as in any preceding claim wherein said second and fourth means (18,34) sense different parameters.

Inventors: MILLERHAGEN JAY O, SPINELLI JULIO C, WARREN JAY A, MILLERHAGEN, JAY O., SPINELLI, JULIO C., WARREN, JAY A.
Applicants: CARDIAC PACEMAKERS INC, CARDIAC PACEMAKERS, INC.
Application year: 1992
Main classification: A61N1
IPC codes: A61N1