PCP RECEPTOR LIGANDS AND THE USE THEREOF

Abstract: The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives thereof. The invention also relates to the use of such compounds for the treatment or prevention of neuronal loss in ischemia, hypoxia, brain or spinal cord trauma, as well as for the treatment of Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome.

Description: PCP RECEPTOR LIGANDS AND THE USE THEREOF Field of the Invention The invention is in the field of pharmaceutical compositions which are useful for the prevention and/or treatment of neurodegradation and other neuropathological conditions in animals. Background of the Invention The amino acid L-glutamate is widely thought to act as a chemical transmitter substance at excitatory synapses within the central nervous system. Neuronal responses to glutamate are complex and appear to be mediated by at least three different receptor types, i.e., KA, QA and NMDA subtypes, each being named for their relatively specific ligands, i.e., kainic acid, quisqualic acid and N-methyl-D-aspartic acid, respectively. NMDA receptors are strongly involved in nerve cell death which occurs following brain ischemia or hypoxia. Upon the occurrence of ischemic/hypoxic brain insults such as those which occur during spinal or head trauma, stroke or heart attack, an excessive release of endogenous glutamate occurs from nerve terminals deprived of the energy supplies needed to retain the neurotransmitter. The excessive amounts of glutamate cause an over-stimulation of NMDA receptors on nearby neurons. Associated with the NMDA receptors is an ion channel. The recognition site, i.e., the NMDA receptor, is external to the ion channel. When glutamate interacts with the NMDA receptor, it causes the ion channel to open, thereby permitting a flow of cations across the cell membrane, e.g., Ca 2+ and Na + into the cell and K + out of the cell. It is believed that this flux of ions, especially the influx of Ca 2+ ions, caused by the interaction of glutamate with the NMDA receptor plays an important role in neuronal death. See, e.g., Rothman, S.M. and Olney, J.W., Trends in Neurosci. 10(7) :299-302 (1987). Agents which block responses to NMDA receptor activation there¬ fore have potential therapeutic uses in the treatment of neurological disorders and nerve cell death resulting from hypoxia or hypoglycemia or following brain ischemia which occurs during stroke, trauma and heart attack. A number of disorders of the nervous system are associated with neurodegeneration that may be caused by over-activation of NMDA receptors. Antagonists of NMDA receptor-mediated responses have potential therefore for the treatment of such disorders as Alzheimer's disease, Huntington's chorea, amyotrophic lateral sclerosis and Down's Syndrome. Research on the NMDA receptor-ion channel complex has led to the determination of a receptor site within the ion channel known as the PCP receptor. See Vincent, J.P., Kartalovski, B., Geneste, P., Kamenka, J.M. and Lazdunski, M., Proc. Natl. Acad Sci. USA 7-5:4678-4682 (1979); Zukin, S.R. and Zukin, R.S., Proc. Natl Acad. Set USA 76:5372-5376 (1979); Sonders, M.S., Keana, J.F.W. and Weber, E., Trends in Neurosci. U(l)-37-40 (1988); and Anis, N.A., Berry, S.C., Burton, RR. and Lodge, D., Br. J. Pharmacol 79:565-575 (1983). Compounds which bind to the PCP receptor can act as ion channel blockers, thereby interrupting the flow of ions across the cell membrane. In this manner, agents which interact with the PCP receptor act as non-competitive blockers, reducing the agonist action of glutamate at the NMDA receptor. Known PCP receptor ligands include PCP [angel dust], i.e., phencyclidine, analogues such as l-[l-(2-thienyI)**<"yclohexyl]-piρeridine (TCP), benzomorphan (sigma) opiates, dioxolanes and 5-methyl-10,ll- dihydro-5H-dibenzo[a,d]cycloheptene-5,10-imine (i.e., the drug MK-801, see U.S. Patent No. 4,399,141). See, also, Wong, E.H.F., Kemp, J.A., Priestly, T., Knight, A.R., Woodruff, G.N., and Iversen, L.I., Proc. Natl. Acad. Sci. USA £5:7104-7108 (1986). MK-801 is apparently the most potent selective PCP receptor ligand/NMDA channel blocker known to date. European Patent Application Publication No. 0230370, Published July 29, 1987, discloses compounds having the Formula(I): Where R 1 , R 2 , R 3 , and R 4 are H, the compound is MK-801. This compound and derivatives thereof are the subject of a patent to Anderson et al, U.S. Patent No. 4,399,141 (1983). U.S. Patent No. 4,374,838 to Anderson et al. (1983) discloses compounds related to MK-801 of the Formula (II): which are useful as muscle relaxants, antidepressants, anticonvulsants, and in the treatment of mixed anxiety-depression, minimal brain dysfunction, and extrapyramidal disorders. U.S. Patent No. 4,064,139 to Anderson et al (1977) discloses compounds related to MK-801 of Formula (III): SUBSTITUTE SHEET which are useful as minor tranquilizers, anticonvulsants, muscle relaxants, and in the treatment of extrapyramidal disorders such as Parkinson's disease. U.S. Patent No. 3,509,158 to Dobson et al. (1970) discloses 10,5- (iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]-cycloheptene and deriva¬ tives thereof of the Formula (IV): H 2 C-N-R wherein Z represents a group selected from the group consisting of These compound are reportedly useful as trichomonacidal, anti- convulsant, anti-parasitic, anti-inflammatory and hypotensive agents. U.S. Patent No. 4,232,158 to Shepard et al. (1980), discloses 10,11- dihydro-5H-d_be__zo[a,d]cyclohepten-5,10-imines and derivatives thereof having the following structural Formula (V): SUBSTITUTE SHEET These compounds are reported useful as anti-anxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as Parkinson's disease. U.S. Patent No. 3,641,038 to Davis et al. (1972), discloses 10,11- dihydro-10,5-(iminomethano)-5H-dibenzo[a,d]-cyclohepten-10-ol derivatives having the Formula (VI): These compounds reportedly possess anti-convulsant activities. U.S. Patent No. 3,542,787 to Dobson et al. (1970), discloses 10,11- dihydro-5, 10-(iminomethano)-5H-dibenzo[a,d]-cycohepten-13-imine having the Formula (VII): This compound reportedly has hypotensive properties. U.S. Patent No. 3,597,433 to Dobson et al. (1971), discloses 10,11- dihydro-5,10-(iminomethano)-5H-dibenzo[a,d]-cycloheptene and its derivatives having the following Formula (VIII): SUBSTITUTE SHEI These compounds reportedly have anticonvulsant activity substantially free from ataxic side-effects. U.S. Patent No. 3,716,541 to Dobson et al. (1973), discloses 11- substituted derivatives of 10,ll-dihydro-5,10-(immomethano)-5H- dibenzo[a,d]-cycloheptene having the Formula (IX): The compounds reportedly exhibit central nervous system depressant and anticonvulsant properties without causing ataxia. U.S. Patent No. 3,717,641 to Kocsis et al. (1973), discloses 5,6,ll,12-tetrahydrodibenzo[a,e]cycloocten-5,ll-imine having the Formula (X): These compounds reportedly have anti-tussive and musculotropic spasmolytic activities. U.S. Patent No. 3,892,756 to Nedelec et al. (1975), discloses 5,10- imino-dibenzo-cycloheptenes having the Formula (XI): SUBSTITUTE SHSi These compounds are reportedly useful as stimulants and anticonvulsants. U.S. Patent No. 4,009,273 to Nedelec et al. (1977), discloses compounds of the Formula (XII): These compounds are reportedly useful as stimulants and anticonvulsants. U.S. Patent No. 4,052,508 to Anderson et al. (1977), discloses dihydroanthracen imines and derivatives thereof having the Formula (XIII): These compounds are reportedly useful as minor tranquilizers, anticonvulsants, muscle relaxants, and in the treatment of extrapyramidal disorders such as Parkinson's disease. U.S. Patent No. 4,064,139 to Anderson et al (1977), discloses substituted 9,10-dihydroanthracene-9,10-imines having the Formula (XIV): SUBSTITUTE SHEET These compounds are reportedly useful as minor tranquilizers, anticon¬ vulsants, muscle relaxants, and in the treatment of extrapyramidal disorders such as Parkinson's disease. Despite the development of the above-mentioned derivatives, a need continues to exist for new methods for the freatment or prevention of neuronal loss associated with stroke, ischemia, CNS trauma, and hypoglycemia, as well as for the treatment or prevention of neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome. SUMMARY OF THE INVENTION The invention relates to a method of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, and hypoglycemia, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, comprising administering to an animal in need of such treatment a compound of the Formula (XVI): wherein: R is hydrogen, --C 6 acyl, C r C 6 alkyl, aryl, C r C 6 alkoxycarbonyl, C j -C 10 aralkyl, C,-C 6 alkenyl, C,-C 15 dialkylaminoalkyl, C r C 6 hydroxyalkyl, C 2 -C 6 alkynyl, C j -C^ trialkylsilyl, C 4 -C 10 alkylcycloalkyl, or C 3 -C 6 cycloalkyl; R 1 is hydrogen, C r C 6 alkyl, C,-C 6 alkenyl, Cj-C w aralkyl, C r alkoxy, C r C 6 alkylamino or -C,; dialkylaminoalkyl; SUBSTITUTE SHEET X and Y are independently selected from the group consisting of a halogen such as chloro, fluoro, bromo, iodo, C r C 6 alkoxy, C 2 -C 6 dialkoxymethyl, C j - alkyl, cyano, C 3 -C 15 dialkylaminoalkyl, carboxy, car- boxamido, C 1 -C 6 haloalkyl, e.g. trifluoromethyl; C r C 6 haloalkylthio, allyl, aralkyl, C 3 -C 6 cycloalkyl, aroyl, aralkoxy, C 2 -C 6 acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C 5 -C 6 heterocycloalkyl, C,-C 6 alkylthio, - alkylsulfonyl, C C 6 haloalkylsulfonyl, C x -C 6 alkylsulfinyl, C j -C 6 haloalkylsulfinyl, arylthio, -Cg haloalkoxy, amino, C r C 6 alkylamino, - C 15 dialkylamino, hydroxy, carbamoyl, -Cg N-alkylcarbamoyl, C^-C^ N,N- dialkylcarbamoyl, nifro and C 2 -C 15 dialkylsulfamoyl; Z represents a group selected from wherein R 2 is hydrogen, alkyl, C 2 -C 6 alkenyl, aralkyl, C 4 -C 15 dialkylaminoalkyl, heterocycloalkyl, C 2 -C 6 acyl, aroyl, or aralkanoyl, and R is C,-C 6 alkyl, C 2 -C 6 alkenyl, phenyl, aralkyl or C 3 -C 15 dialkylaminoalkyl; and n is an integer selected from 0 (X or Y is hydrogen, respectively), 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof; wherein said compound exhibits a high binding activity with respect to the PCP receptor in mammalian nerve cells, and is administered is present in an amount effective to treat or prevent said neuronal loss or to treat said disease. SUBSTITUTE SHEET DESOOPTION OF THE FIGURES Figure 1 depicts a graph showing the in vitro neuroprotective effect of (±) 10,5-(iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cycloheptene (JDDC), (+) IDDC, N-methyl IDDC and a control sample on rat hippocampal cells treated with various concentrations of glutamate. Figure 2 depicts a graph showing the in vivo neurotoxicity protective effect of (+)-IDDC at various dosage levels. DESCRIPTION OF THE PREFERRED EMBODIMENTS The invention relates to a method of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, and hypoglycemia, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, comprising administering to an animal, i.e. a human, in need of such treatment a compound of the Formula (XVI): wherein: R is hydrogen, C,-Cg acyl, C,-C 6 alkyl, aryl, C Cg alkoxycarbonyl, -Cr ø aralkyl, C j - alkenyl, dialkylaminoalkyl, C,-C 6 hydroxyalkyl, CVCg alkynyl, C 3 - 5 trialkylsilyl, C 4 -C 10 alkylcycloalkyl, or -Cg cycloalkyl; R 1 is hydrogen, - alkyl, C 2 -C 6 alkenyl, -C^ aralkyl, C,-Cg alkoxy, C,-C 6 alkylamino, or -C^ dialkylaminoalkyl; X and Y are independently selected from the group consisting of a halogen such as chloro, fluoro, bromo, iodo, C,-C 6 alkoxy, C 2 -C 6 SUBSTITUTE SHEET dialkoxymethyl, C,-C 6 alkyl, cyano, CVC 15 dialkylaminoalkyl, carboxy, car- boxamido, C r Cg haloalkyl, e.g. trifluoromethyl; -Cg haloalkylthio, allyl, aralkyl, C 3 -C 6 cycloalkyl, aroyl, aralkoxy, C 2 -C 6 acyl, aiyl, substituted aryl, heteroaryl, substituted heteroaryl, -Cg heterocycloalkyl, C x -Cg alkylthio, C r Cg alkylsulfonyl, C r C 6 haloalkylsulfonyl, C r C 6 alkylsulfinyl, C r C 6 haloalkylsulfinyl, arylthio, -Cg haloalkoxy, amino, -Cg alkylamino, C 2 - C 15 dialkylamino, hydroxy, carbamoyl, C x -C 6 N-alkylcarbamoyl, C 2 -C 15 N,N- dialkylcarbamoyl, nitro and C 2 -C 15 dialkylsulfamoyl; Z represents a group selected from wherein R 2 is hydrogen, C x -Cg alkyl, C 2 -C 6 alkenyl, aralkyl, C 4 -C 15 dialkylaminoalkyl, heterocycloalkyl, C 2 -C 6 acyl, aroyl, or aralkanoyl, and R 3 is -Cg alkyl, C 2 -C 6 alkenyl, phenyl, aralkyl or C 3 -C 15 dialkylaminoalkyl; and n is an integer selected from 0 (X or Y is hydrogen, respectively), 1, 2, 3 or 4, or a pharmaceutically acceptable salt thereof; wherein said compound exhibits a high binding activity with respect to the PCP receptor in mammalian nerve cells, and is administered in an amount effective to treat or prevent said neuronal loss or to treat said disease. The compounds having Formula (XVI) above may exist in racemic form or in the optically active stereoisomeric form. In addition, the compounds having Formula (XVI) may exist in radiolabeled form, e.g. wherein the one or more of the atoms are substituted by 3 H, U C, 14 C, 18 F, 15 N) 125 T) _31τ 5 35 S Qr 32p SUBSTITUTE SHEET Preferably, the compounds of the invention are those of Formula (XVI) wherein R is H, i.e., those having the following structural Formula (XVII): wherein R 1 , X, Y, Z and n are as defined above. Typical C r Cg alkyl groups include methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, i-butyl, pentyl, i-pentyl and hexyl groups. Typical -Cg acyl groups include acetyl, propanoyl, i-propanoyl, butanoyl, s-butanoyl, pentanoyl and hexanoyl groups. Typical aryl groups include phenyl, naphthyl, phenanthryl and anthracyl groups. Typical C r C 6 alkoxycarbonyl groups include carbonyl substituted by methoxy, ethoxy, propanoxy, i-propanoxy, n-butanoxy, t-butanoxy, i- butanoxy, pentanoxy, and hexanoxy groups. Typical aralkyl groups include the above-listed C,-C 6 alkyl groups substituted by phenyl, naphthyl, phenanthryl and anthracyl groups, e.g. benzyl, phenethyl, phenylpropyl, phenylisopropyl, and phenylbutyl. Typical C 2 -C 6 alkenyl groups include vinyl, allyl, 2-butenyl, 2- pentenyl, and 2-hexenyl groups. Typical -Cg alkynyl groups include ethyhyl and propargyl groups. Typical halo groups include fluorine, chlorine, bromine and iodine. Typical aroyl groups include carbonyl substituted by phenyl, naphthyl, phenanthryl and anthracyl groups. Typical aralkanoyl groups include carbonyl substituted by the above-listed aralkyl groups. Typical aralkoxy groups include the above listed C,-C 6 alkoxy groups substituted by phenyl, naphthyl, phenanthyl and anthracyl groups. SUBSTITUTE SHEET Typical substituted aryl groups include the above-listed aryl groups substituted by halo, hydroxy, amino, and the like. Typical heteroaryl groups include furyl, thienyl, pyπolyl, thiazolyl, pyridyl, pyrimidinyl, pyrizinyl and oxazolyl groups. Typical substituted heteroaryl groups include the above-listed heteroaryl groups substituted by halo, C,-C 6 alkyl and the like. Typical C 5 -C 6 heterocycloalkyl groups include tetrahydrofuranyl, tetrahydropyranyl, piperidinyl and pyπolidinyl groups. Typical C 3 -C 15 -dialkylaminoalkyl groups include N,N- dimethylaminomethyl, N,N-dimethylaminoethyl, N,N-dimethylaminopropyl and N,N-dimethylaminobutyl. With reference to Formula (XVI), a most preferred compound, wherein X, Y, R and R 1 are hydrogen (n is 0), is (+) and/or (-) 10,5- (iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cycloheρtene (IDDC) having the following Formula (XVIII): With reference to Formula (XVI), a second prefeπed compound wherein X, Y and R are hydrogen (n=0) and R 1 is CH 3 is (+) and/or (-) 5-methyl-10,5-(iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cycloheptene (5-methyl-IDDC) having the following Formula (XIX): SUBSTITUTE SHEET With reference to Formula (XVI), a third prefeπed compound wherein X, Y and R 1 are hydrogen (n=0) and R is CH 3 is (+) and/or (-) N-methyl-10,5-(iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cycloheptene (N-methyl-IDDC) having the following Formula (XX): With reference to Formula (XVI), a fourth preferred compound wherein X and Y are hydrogen and R and R 1 are CH 3 is (+) and/or (-) 5-methyl-N-methyl- 10, 5-(iminomethano)- 10, 11 -dihydro-5H- dibenzo[a,d]cycloheptene (5-methyl-N-methyl-IDDC) having thefollowing Formula (XXI): The compounds of the invention exhibit high binding activity with respect to the PCP receptor in mammalian nerve cells. Compounds with especially high binding activity include those represented by Formulae (XVIII) - (XXI), above. The present invention is also directed to novel derivatives of IDDC (IDDC = (+) and/or (-) 10,5-(iminomethano)-10,ll-dihydro- 5H-dibenzo[a,d]cycIoheptene), pharmaceutical compositions thereof, as well as the use thereof for treating or preventing neuronal loss and inhibiting NMDA receptor-ion channel related neurotoxicity. The novel IDDC derivatives which may be used in the practice of the invention include (-)-3-Chloro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, (+) 3-Chloro-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo-[a,d]cycloheptene, (-)-N-methyl-3-Chloro-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, (+)-N-methyl-3-Chloro-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-iodo-5- (iminomethano)-10,ll-d_hydro-5H-dibenzo-[a,d]cycloheptene, N-methyl-3- iodo-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 7- Methoy-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-bromo-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-chloro-7-methoxy-5-(iminomethano)-10, 11-dihydro- 5H-dibenzo[a,d]cycloheptene, 3-bromo-7-methoxy-5-(iminomethano)- 10, 1 l-dihydro-5H-dibenzo[a,d]cycloheptene, 7-Chloro-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-amino-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo[a,d]cycloheptene, .3-bromo-N-methyl-5- (iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cycloheptene, 3-Bromo-7- methoxy-N-methyl-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo[a,d]cycloheptene, (-)-3-fluoro-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, ( + )-3-fluoro-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, (-)-N- methyl-3-fluoro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, (+)-N-methyl-3-fluoro-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo-[a,d]cycloheptene, 3-methoxy-5-(iminomethano)- 10, 1 l-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-nitro-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-azido-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-trifluoromethyl-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptenejN-methyl-3- trifluoromethyl-5-(iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cyclo- heptene, 3,7-difluoro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene,3-phenyl-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene,3-amino-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, 8-hydroj^-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, 3-hydro^-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- SUBSTITUTE SHEET [a,d]cycloheptene, 8-methoxy-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo-[a,d]cycloheptene, 3-cyano-5-(iminomethano)-10, 11-dihydro- 5H-dibenzo-[a,d]cycloheptene, and 3-methylthio-5-(_minomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene. Such IDDC derivatives may be racemic or optically pure, e.g. the (+) or (-) optical isomers. Further, this invention relates to a method of ameliorating the neurotoxic effect induced by glutamate interacting with the NMDA receptor of a nerve cell, comprising the administration, to an animal, e.g., a human being, exhibiting symptoms of or susceptible to such neurotoxic effect, of a compound of the invention which has a high affinity for the PCP receptor of the nerve cell in an amount effective to block the ion channel of the NMDA receptor-ion channel complex. Such neurotoxic effects may be caused by ischemic brain insults which cause excessive release of endogenous glutamate. The pharmaceutical compositions of the invention may be administered prophylactically, for example, before a surgical procedure or other treatment which may be expected to cause reduced blood flow to the brain or spinal cord, thereby, preventing or ameliorating neurodegradation. The pharmaceutical compositions of the invention may also be administered after trauma to, for example, the head or spinal cord to prevent or ameliorate the resulting neurodegeneration which may result therefrom. A number of disorders of the nervous system are associated with neurodegradation that may be caused by over-activation of NMDA receptors. Therefore, agents which block responses to NMDA receptor activation have therapeutic use in the treatment of neurological disorders and also in the prevention of nerve cell death resulting from hypoxia or hypoglycemia or following brain ischemia which occurs during stroke, trauma and heart attack. Antagonists of NMDA receptor-mediated responses also are useful for the treatment of such disorders as Alzheimer's disease, Huntington's chorea, amyotrophic lateral sclerosis and Down's Syndrome. SUBSTITUTE S The invention also relates to a method of inhibiting NMDA receptor ion channel-related neurotoxicity comprising administering to an animal a compound of Formula (XVI) which possesses a high affinity for the PCP receptor of a nerve cell, in an amount effective to inhibit the neurotoxicity. One of ordinary skill in the art may readily determine the activity of a particular compound represented by Formula (XVI) as a non- competitive blocker of NMDA receptor agonist by: (a) determining the binding affinity with respect to the PCP receptor by competitive displacement of tritiated thienylcyclohexylpiperidine ([ 3 H]TCP; see Vignon et al, Brain Res. 280:194-197 (1983); Contreras et al, Neurosci. Lett. 67:101-106 (1986)); (b) evaluating the abihty of compounds to block the passage of ions through ion channels by measurement of electrical current through the channel (Huettner and Bean, Proc. Natl. Acad. Sci. (USA) #5:1307-1311 (1988)); (c) in vitro cytotoxicity studies measuring the abihty of the compound to prevent nerve cell death caused by exposure to glutamate; and/or (d) determination of in vivo neuroprotective abihty using animal models. Evaluation of the binding activity of organic compounds with respect to the PCP receptor is performed using radioligand binding assays. The compounds are tested to determine their abihty to displace tritiated- TCP and tritiated-MK-801 which are used to label PCP receptors. Evaluating the competitive displacement binding data, the prefeπed compounds are those which exhibit a high affinity (i.e., low IC 50 value) for the PCP receptors. Under the binding activity studies, an IC 50 value of at most about 1000 nM, preferably at most about 500 nM, indicates a high binding affinity. In the present application, the term "high affinity" is intended to mean a compound which exhibits an IC 50 value of at most about 1000 nM. In the electrophysiological studies the compounds are evaluated with respect to their abihty to block the ion channel of the NMDA SUBSTITUTE SHEET receptor channel complex and thereby inhibit Ca 2+ and Na + ion flow into the nerve cell. Initially, the ion channels are opened by activating the NMDA receptor. Ion flow is determined by measuring the passage of electrical current, i.e., a use-dependant decrease in electrical cuπent indicates blocking of the ion channel due to binding of a ligand at a site within the channel. A use-dependent block means that as more NMDA receptor- channel complexes are activated by glutamate, blockage of the channels by the non-competitive blocking agent become more effective. In the cytotoxicity studies, cultured mammalian neurons expressing EAA receptors are exposed in vitro to glutamate and the particular compound under investigation. The survival percentage of cells indicates the abihty of the compound to protect against glutamate-induced neuronal death. In the in vivo neurotoxicity studies, the experimental model of McDonald, D.W., et al., (In: Sigma and Phencyclidine-like Compounds as Molecular Probes in Biology, Ed. Domino, E.F., and Kamenka, J.-M., pp.697-707 (1988), NPP Books, Ann Arbor, Michigan) may be employed. In this model, NMDA injection into one cerebral hemisphere causes injury which resembles the lesion produced by hypoxia-ischemia. The abihty of compounds to limit the NMDA-induced lesion is a measure of their neuroprotective properties; since the compounds may be admin¬ istered intraperitoneally, the model can also provide information about a compound's abihty to cross the blood-brain barrier. In general, the compounds having Formula (XVI) are prepared according to Scheme I shown below, for example, by heating the diaryl derivative having Formula (XXII) with bromoacetaldehyde diethylacetal in a polar aprotic solvent. Polar aprotic solvents which can be used for this purpose include N,N-dimethylformamide (DMF) and dimethyl- sulfoxide (DMSO). The temperature of the reaction mixture may range from 70°C to 120°C. The product having the Formula (XXIII) is then SUBSTITUTE treated with an acid such as trifluoromethanesulfonic acid or 70% perchloric acid in a solvent such as chloroform or dichloromethane at ambient temperature to give a compound having the Formula (XXIV). This compound may then be derivatized at the nitrogen atom with a suitable electrophile to give the compound represented by Formula (XVI). For example, the N-methyl derivative may be prepared by reaction of (XXIV) with formaldehyde and sodium borohydride. Alternatively, the nitrogen of Formula (XXIV) maybe reacted with an alkyl hahde, alkanoyl hahde, or other suitable electrophile. Where X and Y are not hydrogen, the product having Formula (XVI) may be prepared by selecting an appropriately substituted diaryl derivative (XXII) which may be prepared by electrophilic substitution on the phenyl ring(s) according to methods known to those skilled in the art. Where Z is a carbon atom bearing a hydroxy or an alkoxy sub- stituent, the compounds may be prepared according to U. S. Patent Nos. 3,509,158, 3,426,015 and 3,361,767, the disclosures of which are incorporated herein by reference. SUBSTITUTE SHEET Scheme I The 5-substituted derivatives of Formula (XVI) may be prepared according to Scheme II shown below, for example, by treatment of the diaryl derivative (XXII) with an al ynyl derivative (XXV) such as 3- bromo-1-proρyne in an alcohohc medium containing a base such as potassium carbonate to give the substituted N-propargyl-l,2-diaryl- ethylamine (XXVI). Where Z is a carbon atom bearing a hydroxy group, the hydroxy group may be protected by a suitable hydroxy protecting group such as benzyl and the like. Treatment of (XXVI) with an acid such as trifluoromethanesulfonic acid gives a compound having formula (XXVH). This product may be further derivatized at the nitrogen or hydroxy group (where Z is substituted by alkoxy or acyloxy) by treatment with an appropriate electrophile, as discussed above. Scheme II (XXVII) A so nc u e w t n t e scope o t e present nvent on are the optical isomers of the compound having Formula (XVI). The optical isomers may be separated by classical resolution techniques by, for example, formation of a salt of the amino group of Formula (XVI) with an opticaUy active acid. A particularly preferred acid for this purpose is (+)-di- toluoyl-D-tartaric acid. The resulting diastereoisomeric salt may then be separated by crystallization, chromatography, or by taking advantage of the differing solubilities of the two diastereoisomeric salts. The free base may then be isolated by treatment with a base such as aqueous ammonia and extraction with an organic solvent Alternatively, the optical isomers may be prepared by resolution of the diaryl derivative (XXII). For example, 1,2-diphenylethylamine may be resolved by preparation of corresponding diastereoisomeric salt with an optically active acid. A particularly preferred acid for this purpose is L- (+)-tartaric acid. The diastereoisomeric salt may be separated by crystallization followed by isolation of the free base as discussed above. The optically active 1,2-diphenylethylamine may then be carried through the reaction sequence shown in Scheme I or 13 to give the optically active product having Formula (XVI). The above synthesis was readily adapted to allow determination of the absolute configuration of (-f-)-IDDC as follows. (-)-l,2-Diphenyl- ethylamine had already been shown (M. Nakazaki et al, Bull Soc. Chem. Japan 36:316 (1963)) to have the R-absolute configuration. During the synthesis of (+)-IDDC from (R)(-)-l,2-diphenylethylamine the R- configuration is retained and it becomes C-10 in the IDDC molecule. Therefore the absolute configuration of (+)-IDDC is R at C-10. Owing to the geometric constraints imposed on the molecule by the bicyclic ring structure, the absolute configuration at C-5 in (+)-IDDC must then be S. The full name of (+)-IDDC is therefore (+)-10(R),5(S)-(iminomethano)- 10, ll-dihydro-5H-dibenzo[a,d]cycloheptene. Also included within the scope of the present invention are the non-toxic pharmaceutically acceptable salts of the compounds having Formula (XVI). Acid addition salts are formed by mixing a solution of a compound having Formula (XVI) with a solution of a pharmaceutically acceptable non-toxic acid such as hydrochloric acid, fumaric acid, maleic acid, succinic acid, acetic acid, citric acid, tartaric add, carbonic acid, phosphoric acid, oxalic acid, and the like. In the method of treatment or prevention of neuronal loss in ischemia, brain and spinal cord trauma, hypoxia, and hypoglycemia, as well as for the treatment of Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's Syndrome, the pharmaceutical compositions of the invention may comprise the compound of Formula (XVI) at a unit dose level of about 0.01 to about 500 mg/kg of body weight, or an equivalent amount of the pharmaceutically acceptable salt thereof, on a regimen of 1-4 times per day. When used in a method of treating a disease in which the pathophysiology of the disorder involves NMDA receptor-ion channel related neurotoxicity, the compound having Formula (XVI) may be administered at a unit dosage level of from about 0.01 to about 500 mg kg of body weight, or an equivalent amount of the pharmaceutically acceptable salt thereof on a regimen of 1-4 times per day. Of course, it is understood that the exact treatment level will depend upon the case history of the animal, e.g., human being, that is treated. The precise treatment level can be determined by one of ordinary skill in the art without undue experimentation. The pharmaceutical compositions of the invention may be administered to any animal which may experience the beneficial effects of the compounds of the invention. Foremost among such animals are humans, although the invention is not intended to be so limited. The pharmaceutical compositions of the present invention may be administered by any means that achieve their intended purpose. For example, administration may be by parenteral, subcutaneous, intravenous, intramuscular, intraperitoneal, transdermal, or buccal routes. Alternatively, or concurrently, administration may be by the oral route. The dosage administered will be dependent upon the age, health, and weight of the recipient, kind of concurrent treatment, if any, frequency of treatment, and the nature of the effect desired. In addition to the pharmacologically active compounds, the new pharmaceutical preparations may contain suitable pharmaceutically acceptable carriers comprising excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. Preferably, the preparations, particularfy those preparations which can be administered orally and which can be used for the preferred type of administration, such as tablets, dragees, and capsules, and also preparations which can be administered rectally, such as suppositories, as well as suitable solutions for administration by injection or orally, are present at a concentration of from about 0.01 to 99 percent, together with the excipient. The pharmaceutical preparations of the present invention are manufactured in a manner which is itself known, for example, by means of conventional mixing, granulating, dragee-making, dissolving, or lyophilizing processes. Thus, pharmaceutical preparations for oral use can be obtained by combining the active compounds with solid excipients, optionally grinding the resulting mixture and processing the mixture of granules, after adding suitable auxiliaries, if desired or necessary, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as saccharides, for example lactose or sucrose, mannitol or sorbitol, cellulose preparations and/or calcium phosphates, for example tricalchim phosphate or calcium hydrogen phosphate, as well as binders such as starch paste, using, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, methyl cellulose, hydroj propylmethylcellulose, sodium carboxymethylcellulose, and/or pofyvinyl pyrrolidone. If desired, disintegrating agents may be added such as the above-mentioned starches and also carboxymethyl-starch, cross-linked pofyvinyl pyrrolidone, agar, or alginic acid or a salt thereof, such as sodium alginate. Auxiliaries are, above all, flow-regulating agents and lubricants, for example, silica, talc, stearic acid or salts thereof, such as magnesium stearate or calcium stearate, and/or polyethylene glycol. Dragee cores are provided with suitable coatings which, if desired, are resistant to gastric juices. For this purpose, concentrated saccharide solutions may be used, which may optionally contain gum arabic, talc, pofyvinyl pyrrolidone, polyethylene glycol and/or titanium dioxide, lacquer solutions and suitable organic solvents or solvent mixtures. In order to produce coatings resistant to gastric juices, solutions of suitable cellulose preparations such as acetyl- cellulose phthalate or hydro5ypropymethyl-cellulose phthalate, are used. Dye stuffs or pigments maybe added to the tablets or dragee coatings, for example, for identification or in order to characterize combinations of active compound doses. Other pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer such as glycerol or sorbitol. The push-fit capsules can contain the active compounds in the form of granules which may be mixed with fillers such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds are preferably dissolved or suspended in suitable liquids, such as fatty oils, or liquid paraffin. In addition, stabilizers may be added. Possible pharmaceutical preparations which can be used rectally include, for example, suppositories, which consist of a combination of one or more of the active compounds with a suppository base. Suitable suppository bases are, for example, natural or synthetic triglycerides, or paraffin hydrocarbons. In addition, it is also possible to use gelatin rectal capsules which consist of a combination of the active compounds with a base. Possible base materials include, for example, liquid triglycerides, polyethylene glycols, or paraffin hydrocarbons. Suitable formulations for parenteral administration include aqueous solutions of the active compounds in water-soluble form, for example, water-soluble salts. In addition, suspensions of the active compounds as appropriate oily injection suspensions may be administered. Suitable lipophilic solvents or vehicles include fatty oils, for example, sesame oil, or synthetic fatty acid esters, for example, ethyl oleate or triglycerides. Aqueous injection suspensions may contain substances which increase the viscosity of the suspension include, for example, sodium carboxymethyl cellulose, sorbitol, and/or dexfran. Optionally, the suspension may also contain stabilizers. The following examples are illustrative, but not limiting, of the method and compositions of the present invention. Other suitable modifications and adaptations of the variety of conditions and parameters normally encountered in clinical therapy and which are obvious to those skilled in the art are within the spirit and scope of the invention. EXAMPLES Example 1: Synthesis of IDDC A. Synthesis of N-(2^-dietho_yethyl)-diphenylethylamine N-(2,2-dietho_yethyl)-diphenylethylamine was prepared according to the procedure of Takayama, H., Chem. Lett. 865 (1978). To a stirred solution of 1,2-diphenylethylamine (3.94 g, 20.0 mmol, Aldrich Co., used as received) in N,N-dimethylformamide (DMF) (10 ml) at 80-90 °C was added dropwise over 1 h freshly distilled bromoacetaldehyde diethylacetal (4.50 g, 22.5 mmol, Aldrich Co.). After 1 h, potassium carbonate (2.76 g, 20.0 mmol) was added. After 13 h, the brown mixture was cooled to 25°C and then the mixture was diluted with 1 N NaOH (200 ml), extracted twice with CH 2 C1 2 (total of 100 ml), and dried (MgS0 4 ). The solvent was evaporated and the residue was distilled to give N-(2,2- diethoxyethyl)-diphenylethylamine (5.29 g, 84%): bp 150-160°C/0.50 mm; Η NMR (CDC1 3 ) δ 1.10 (t, 3), 1.12 (t, 3), 1.70 (bs, 1), 2.50 (dd, 1), 2.58 (dd, 1) 2.91 (dd, 1), 2.98 (dd, 1), 3.39 (dt, 1), 3.44 (dt, 1), 3.54 (dt, 1), 3.59 (dt, 1), 3.86 (dd, 1), 4.53 (dd, 1), 7.16-7.40 (m, 10); 13 C NMR (CDC1 3 ) δ 15.5 (q), 45.5 (t), 50.0 (t), 62.0 (t), 62.2 (t), 64.9 (d), 102.0 (d), 126.5, 127.3, 128.5, 129.5 (all d), 139.0, 143.8 (all s). -28- B. Synthesis of IDDC and the hydrochloride salt thereof To a stirred solution of the acetal obtained above (2.16 g, 6.90 mmol) in CDCI 3 (5 ml) at 25°C was added dropwise trifluoromethane- sulfonic acid (4.0 g, 36 mmol, Aldrich Co.). NMR spectroscopy indicated that the reaction was complete after 54 h. The black solution was diluted with water (50 ml), made basic with 1 N NaOH (200 ml), and extracted with CH 2 α 2 . The extract was concentrated to dryness and the residue was purified by flash chromatography over silica gel. Elution with 10:1 ether-THF gave first a small amount of 1,2-diphenylethylamine followed by a colorless fraction which was distilled at 170°C/0.5 mm to give an oily product (1.15 g, 75%) which solidified upon standing: mp 79-81 °C (litmp 74-78° Dobson, T-A, Chem. Abstr. 73:3816 (1970), U.S. Patent No. 3,509,158 (1970); lit m.p. 79°C, Takai, H. et al, Chem. Pharm. Bull 34:1901 (1986)); Η NMR (CDCl,) δ 2.18 (bs, 1, NH), 3.23 (dd, 1, J=17.5 and 32, H-ll), 333 (dd, 1, J=11.3 and 4.7, H-12), 3.50 (dd, 1, J=17.5 and 3.7, H-ll), 3.67 (d, 1, J=1L3, H-12), 3.92 (d, 1, J=4.7, H-5), 4.33 (dd, 1 J=3.7and3.2, H-10), 7.04-7.38 (m, 8H-1-4; 6-9); "CNMR (CDC1 3 ) δ41.8 (t), 47.0 (d), 50.8 (t), 55.1 (d), 125.1, 125.6, 126.1, 126.8, 126.9, 127.3, 128.1, 131.5 (all d), 135.4, 140.5, 141.6, 143.1 (all s); MS m/e 221 (40, M + ), 220 (35), 192 (100), 191 (47). HQ gas was bubbled into a solution of the product (700 mg) in ether (10 ml) and MeOH (10 ml) at 25-30 °C until no more precipitate formed. The solvent was removed and the residue was dissolved in hot EtOH and than allowed to cool, giving the hydrochloride salt of JDDC (429 mg, 52%) as white ciystals: mp 305-307°C (lit. mp. > 270°C, see Dobson, TA. et al, U.S. Patent No. 3,509,158 (1970); Chem. Abstr. 73:3816 (1970)); Η NMR (CD 3 OD) δ 3.31 (dd, 1), 3.54 (dd, 1), 3.78 (dd, 1), 3.85 (d, 1), 4.25 (d, 1), 5.01 (t, 1), 7.07-7.46 (m, 8); U C NMR (CD 3 OD) δ 36.5 (t), 43.5 (d), 48.3 (t), 54.9 (d), 125.7, 126.6, 126.8, 127.7, 127.9, 128.1, 129.5, 130.9 (all d), 132.0, 132.1, 140.0, 140.3 (all s). Example 2: Synthesis of 5-Methyl-IDDC A. N-Propargyl-l,2-d_phenylethylam_ne To a stirred solution of 1,2-diphenylethylamine (930 mg, 4.20 mmol) in EtOH (30 ml) were added 3-bromo-l-propyne (700 mg, 5.30 mmol) and potassium carbonate (1.38 g, 10.0 mmol). The mixture was refluxed for 16 h and then more 3-bromo-l-propyne (100 mg) was added. The mixture was refluxed another 6 h and then it was cooled, diluted with 1 N NaOH (200 ml) and extracted with CH 2 C1 2 . The extract was dried (MgS0 4 ) and concentrated. The residue was purified by flash chroma- tography. Elution with 1:1 hexanes-CH 2 Cl 2 gave first N,N-di-propargyl- 1,2-diphenylethylamine (218 mg, 19%) [Η NMR (CDC1 3 ) δ 2.34 (t, 2), 2.83 (dd, 1), 3.53 (dd, 1), 3.63 (dd, 2), 3.71 (dd, 2), 3.85 (dd, 1), 6.89-6.92 (m, 2), 7.14-7.26 (m, 8); * *C NMR (CDC1 3 ) δ 40.5 (t), 40.9 (t), 68.2 (d), 73.4 (d), 79.4 (d), 126.1, 127.6, 128.1, 128.3, 128.8, 129.7, 129.8 (all d), 138.8, 140.8 (all s)] followed by N-propargyl-l,2-diphenylethylamine. Distillation at 180°C/0.5 mm gave the pure compound (583 mg, 59%) as a colorless oil: Η NMR (CDC1 3 ) δ 1.69 (bs, 1), 2.20 (t, 1), 2.95 (dd, 1), 3.06 (dd, 1), 3.24 (dd, 1), 3.36 (dd, 1), 4.21 (dd, 1), 7.25-7.50 (m, 10); 13 C NMR (CDC1 3 ) δ 36.0 (t), 45.1 (t), 62.6 (d), 71.6 (d), 82.2 (s), 126.7, 127.6, 127.8, 128.7, 129.5 (all d), 138.6, 142.7 (all s). B. 5-Methyl-IDDC A solution of N-propargyl-l,2-diphenylethylamine (125 mg, 0.530 mmol) in chloroform (0.5 ml) and trifluoromethanesulfonic acid (500 mg, 3.33 mmol) was stirred for 48 h at 25 °C. NMR spectral analysis of an aliquot revealed that only about a 40% conversion had taken place. Therefore, additional trifluoromethanesulfonic acid (500 mg) was added. After 24 h, the black solution was made basic with 1 N NaOH (50 ml) and extracted with CH 2 C1 2 . The solvent was evaporated and the residue was distilled to give the product (96 mg, 78%) as a colorless oil, bp 190- 200°C/0.5 mm. Η NMR (CDC1 3 ) δ 1.88 (s, 3), 2.44 (s, 1), 3.09 (d, 1), 3.32 (dd, 1), 3.59 (d, 1), 3.61 (dd, 1), 4.35 (dd, 1), 7.07-7.42 (m, 8); K C NMR (CDC1 3 ) δ 22.6 (q), 41.9 (t), 55.5 (d), 58.1 (t), 62.6 (s), 122.9, 123.9, 125.0, 125.7, 126.4, 126.6, 1273, 131.7 (all d), 136.3, 140.6, 144.3, 145.5 (all s). Example 3: Preparation of (+)-IDDC A. Resolution of (±)-l^diphen)ieth * ylan_ine The general procedure of V. M. Potapov et al was adapted for the following resolution (Potapov, V.M., et al, J. Org. Chem. USSR 16: 683 (1980)). To a stirred solution at 45°C of 9.5013 grams (63.2 mmoles) of L-(+)-tartaric acid (Mallinkrodt, used as received) in 400 mL of water was added dropwise, 24.7673 grams (125.5 mmoles) of (±)-l,2- diphenylethylamine (Aldrich, used as received). A white precipitate formed immediately. After stirring for 2.5 hours at 25 °C the precipitate was collected and partialfy air dried to yield 94 grams of white solid. These 94 grams were dissolved in 300 mL of boiling water then filtered while hot to give a clear, colorless solution. QystaJlization commenced from this solution within 20 min. The collected crystals amounted to 31.6 grams after partial air drying. Subsequently, five more recrystallizations were performed on this material using proportional amounts of boiling water to give 905.2 mg of the partialfy resolved diastereoisomeric salt of (-h)-L-tartaric acid and (+)-l(R),2-diphenylethylamine as white microcrystals; p 222.5-223.5°C dec, [α] D 19 =-513°, C = .92, H 2 0. Nakazaki et al, Bull Chem. Soc. Jpn. 56:161 (1963) report the following physical constants: (- )-tartrate of (-)-l(R),2-diphenylethylamine MP 229- 230°C, [α] D 19 = -553°, C= .92, H 2 0; (-)-l(R),2-diphenylethylamine [α] D 19 = -51.2°, C=3.7, EtOH. The mother liquors from the last four recrystallizations were combined. The aqueous solution was concentrated, made basic by the addition of sohd NaOH and extracted with three portions of CH 2 C1 2 . The combined organic layers after drying (K 2 C0 3 ) and removal of the solvent in vacuo yielded 2.5397 grams of partialfy resolved (-)-l(R),2-diphenylethylamine; [α] D 19 =-44.0°C, C=3.7, EtOH (Nakazaki, M., et al; supra). The amine (2.5055 grams, 12.7 mmoles) was added dropwise to a stirred solution at 45° of 1.8116 grams (12.1 mmoles) of I_-(+)-tartaric acid (Mallinkrodt, used as received) in 40 mL of water. The resulting white precipitate was collected after the mixture had stirred at ambient temperature for 12 hours. The collected sohd was recrystall- ized three times from boiling H 2 0 to yield 815.2 mg of the diastereo-isom- eric salt of (+)-I_-tartaric acid and (-)-l(R),2-diphenylethylamine as white microcrystals; mp 224-225°C dec, [α] D 19 = -54.8°, C = .92, H 2 0. Nakazaki et al, supra. The salt (806.6 mg) was dissolved in 50 mL of IN NaOH and 25 mL of CH_C1 2 . The layers were separated and the aqueous portion was extracted with 2 X 25 mL of CH 2 C1 2 . The combined organic layers were washed with 15 ml of IN NaOH, dried (K 2 C0 3 ), and the solvent removed at reduced pressure to give 449.1 mg of (-)-l(R),2- diphenylethylamine as a colorless liquid; [α] D 19 = -50.1°, C = 3.7, EtOH. B. Preparation of N-(l(R),2-diphenylethyl)aminoacetaldehyde diethyl acetal The general procedure of Suzuki, T., et al, Chem. Pharm. Bull 54:1988 (1986), was adapted for the following alkylation. To a stirred mixture at 90°C of 249.5 mg (1.3 mmoles) of (-)-l(R),2-dipheny- lethylamine and 193.6 mg (1.4 mmoles) of anhydrous potassium carbonate (Baker, used as received) in 2.5 ml of N,N-dimethylformamide (Baker, used as received) was added dropwise, over two hours, a solution of 284.1 mg (1.4 mmoles) of bromoacetaldehyde diethylacetal (Aldrich, distilled, bp 83 °C/ 40mm). The resulting mixture was heated (95-105 °C) with stirring. After 16 hours the reaction mixture was cooled to 10 °C, 50 mL of IN NaOH was added followed by 25 mL of CH 2 C1 2 . The layers were separated and the aqueous layer was extracted with 2 X 15 mL of CH 2 C1 2 . The combined organic layers were washed with 10 mL of IN NaOH, dried (K 2 C0 3 ) and the solvent evaporated at reduced pressure to give 346.1 mg of brown oil. The oil was distilled (180-190°C, 0.05 mm/Hg) using a Kugelrohr apparatus to give 315.5 mg of light yellow oil. The yellow oil (304.2 mg) was chromatographed (lOg sihca gel) using 25 mL Et^O followed by 40 mL 3:1 Et^O THF then 40 mL 2:1 E /T F as eluent The fractions containing the less polar material (Rf .56) were combined and the solvent removed at reduced pressure yielding 283.3 mg of N- (l(R),2-d_phenylethyl)aminoacetaldehyde diethyl acetal as a clear, light yellow liquid (71% yield). Η NMR (CDα 3 ): δ 1.09 and 1.11 (t, 6H, J = 6.9, -CH 3 ), 1.76 (bs, 1H, NH), 2.51 (dd, 1H, J=12.0 and 6.3, -CH 2 -N), 2.57 (dd, 1H, J=12.0 and 5.0, -CH 2 -N), 2.91 (dd, 1H, J=13.2 and 8.5, CH 2 -Phenyl), 2.98 (dd, 1H, 1=13.2 and 5.9, -CH 2 -Phenyl), 3.37 and 3.43 (dt, 2H, J=93 and 7.2, -CH 2 - O), 3.53 and 3.57 (dt, 2H, J=93 and 6.9, -CH 2 -0), 3.86 (dd, 1H, J=8.5 and 5.9, -CH-N), 4.53 (dd, 1H, J=6.3 and 5.0, -CH-O), 7.16 -7.34 (m, 10H, Phenyl). C. Preparation of (+)-10^-(I_n_nσmethano)-10,ll*-dihydro-5H- dibe__zo[a,d]cyclolιeptene (IDDC) The general procedure of T. Suzuki et al, supra, was adapted for the following cyclization. To 6 ml of perchloric acid (70% aqueous) at 24°C was added dropwise with stirring over 5 min. 280 mg (8.9 mmoles) of N-(l(R),2-diphenylethyl)aminoacetaIdehyde diethyl acetal. During the addition a brown oil separated. The mixture was stirred for 16 hours at ambient temperature then poured onto 50 mL of 2N NaOH and extracted with 3 X 15 mL of CH 2 C1 2 . The combined organic layers were washed with 15 mL of IN NaOH, dried and the solvent removed at reduced pressure to give 225.4 mg of brown oil. A TLC (THF) showed two spots with Rf values of 0.67 and 0.23. The oil (225 mg) was submitted to flash chromatography (8 grams sihca gel) eluting with 25 mL of E^O, 40 mL 3:1 Btp/THF, 25 mL 2:1 E^O/THF, 25 mL 1:1 Et- 2 0/THF, and 25 mL THF. The fractions containing the more polar material (Rf .22) were combined and the solvent evaporated in vacuo to give 172.1 mg of brown oil. This oil was double distilled (175-185°C, 0.05 mm/Hg) using a Kugelrohr apparatus to give 153.4 mg of (+)-IDDC as a clear light yellow oil that solidified on standing (mp 79-85 °C, [o;] D 2S = +161 °, C = 1, EtOH) (78% yield). Η NMR (CDC1 3 ): δ 2.10 (bs, 1H, -NH), 3.23 (dd, 1H, J = 17.5 and 3.2, H-ll), 3.33 (dd, 1H, J = 11.1 and 4.6, H-12), 3.51 (dd, 1H, J = 17.5 and 3.7, H-ll), 3.67 (d, 1H, J = 11.1, H-12), 3.93 (d, 1H, J = 4.2, H-5), 434 (t, 1H, J = 3.6, H-10), 7.05-730 (m, 8H, H-1,2,3,4,6,7,8,9). - ~ C NMR (CDC1 3 ): δ 41.7 (t, C-ll), 46.9 (d, C- 5), 50.8 (t, C-12), 55.1 (d, C-10), 125.0, 125.6, 126.0, 126.8, 126.9, 127.3, 128.0, 131.5 (d, C-1,2,3,4,6,7,8,9), 135.4, 140.4, 141.6, 143.0 (s, C- 4a,5a,9a,lla). D. Preparation of the Maleate Salt of (+)-IDDC To a stirred solution at 43°C of 50.6 mg (.23 mmoles) of (+)- IDDC in 1.0 ml of EtOH was added a solution of 26.4 mg (.23 mmoles) of maleic acid (Aldrich, used as received) in 0.3 ml of EtOH. Crystal¬ lization begins from the resulting solution in approximately 10 minutes. This mixture was then stirred at ambient temperature. After 14 hours, the white crystals were collected and then reciystallized from 0.4 ml of hot EtOH to give 31.1 mg of the maleate salt of (+)-IDDC (mp 168-168.5°C dec). From the mother liquors were isolated, after recrystallization, two subsequent portions of the maleate salt of 10.2 mg (mp 167-167.5°C dec) and 13.8 mg (mp 164-165.6°C dec). Example 4: Preparation of Optically Active N-Methyl-IDDC To a stirred solution of (+)-IDDC (9.3 mg, 0.04 mol; [α] D =+ 1163°, EtOH, c=l) in acetonitrile (0.4 ml) and 37% aqueous formaldehyde (0.61 mmol) at 25°C was added sodium cyanoborohydride (5.1 mg, 0.08 mmol). The resulting mixture was stirred for 15 min. and then one drop of glacial acetic acid was added to lower the pH to 7 (checked by wet pH paper). The mixture was stirred for 20 h and the solvent was removed in vacuo. The residue was treated with 2 N sodium hydroxide (4 ml) and ether (4 ml). The layers were separated and the aqueous layer was extracted with ether. The combined organic layers were dried (K 2 C0 3 ), filtered, and evaporated to give a clear oil (11 mg) which was purified by preparative TLC on sihca gel. Elution with ethanol gave two bands, R f =0.41 and 0.83. The band at 0.41 was removed and extracted with acetone. The solution was dried (K 2 CO 3 ) and evaporated to give optically active N-methyl IDDC (10.6 mg, 84%) as an off-white oil; Η NMR (CDα 3 ) δ 2.50 (s, 3, N-Me), 2.92 (dd, 1, J=10.5 and 4.8, H-12), 3.00 (dd, 1, J=17.7 and 33, H-ll), 3.58 (dd, 1, J=10.5 and 1.1, H-12), 3.62 (dd, 1, J=17.7 and 3.9, H-ll), 3.83 (dd, 1, J=4.7 and 1.1, H-5), 3.94 (dd, 1, J * =3.9 and 3.0, H-10). 13 C NMR (CDC1 3 ) δ 38.61 (t), 45.2 (q), 47.0 (d), 59.8 (t), 62.7 (d), 125.1, 125.9, 126.0, 126.7, 127.3, 127.8, 131.3 (all d), 135.2, 138.6, 141.4, 142.5 (all s). Example 5: The PCP Receptor Bmding Properties of the IDDC Optical Isomers The PCP receptor binding properties of various compounds of the invention against 3 H-5-methyl-10,ll-dihydro-5H-dibenzo[a,d]cycloheptene- 5,10-imine ( 3 H-MK-801) were determined. The results appear in Table 1, below. Example 6: Elecfrσphysiological Assays (+)-IDDC was tested for its abihty to achieve use-dependent blockage of NMDA-induced (+ glycine) responses on rat hippocampal neurons maintained in cell culture. This compound produced a result very similar to the use dependent blocking action exhibited by MK-801. Hippocampal neurons were obtained from the CA1 region of the hippocampus from 1-3 day-old-newborn rats (Long-Evans). Small blocks of tissue (>lmm 3 ) were incubated in papain (20 units ml "1 ; Worthington- Cooper) for 30 minutes. The tissue was dissociated into a single cell suspension by trituration with a fire-polished Pasteur pipette in complete growth medium (Earle's MEM, 20 mM glucose, 50 units/tail penicillin/streptomycin, 5% heat-inactivated fetal calf serum, Serum Extender from Collaborative Research) containing 2.5 mg/ml bovine serum albumin and 2.5 mg ml trypsin inhibitor (Sigma). The cells were plated onto glass coverslips coated with collagen/pofy-D-fysine. Cultures were fed every 3 days by replacing half the volume of medium. Arabinosylcytosine (5 X lO^M) was added to the cultures for 1 or 2 days during the first week after plating to suppress the proliferation of non- neuronal cells. All electrophysiology experiments were performed with the whole- cell mode of patch clamp recording [Hamill, O.D., Marty, A., Neher, E., Sakman, B., and Sigworth, F.J., Pflugers Arch. 592:85-100 (1981)] from neurons grown for 1-3 weeks in culture. Agonists and agonist antagonist combinations were applied by a U-tube tool (Fenwick et al, J. Physiol 331-577-597 (1982)) to neurons in whole-cell experiments. The external solution contained (in mM) NaCl 140, KC1 3.5, CaCl 2 1, glucose 5, picrotoxinin 0.02, tetrodotoxin (TTX) 5 x 10 *4 , and N-2-hydroxyethyl- piperazme-N'-2-ethanesulf6nic add (HEPES) 10. The pH of this solution was adjusted to 7.4 with NaOH. The internal (patch electrode) solution contained (mM) Cs-methanesulfonate 120, CsCl 10, ethylenegfycol-bis-(β- aminoethylether)-N,N,N',N'-tetraacetic add (EGTA) 10, HEPES 10 (pH adjusted to 7.0 with CsOH). Membrane current was filtered at 4000 Hz (-3dB; 8-ρole Bessel) and recorded on magnetic tape for later analysis. Experiments were performed at room temperature (20-25 c C). [Sources of chemicals: N-methyl-D-aspartate, Cambridge Research Biochemicals; pirotoxinin, Sigma Chemical Company, salts for recording solutions, Aldrich (Gold Label) or Alfa (Puratronic). [ 3 H]Kainate and [ 3 H]CPP and [ 3 H]AMPA were purchased from Dupont/NEN (Boston, MA)]. Three second applications of 50 uM NMDA in the presence of 1 uM glycine resulted in inward whole-cell currents of 100-1000 pA at a holding potential of -60 mV. Repetitive applications (every 30 s) to the same cell produced currents which varied less than 5% over a period of at least 30 minutes. When MK-801 (10 uM) was applied in conjunction with NMDA, the inward current became progressively smaller with serial applications. Recovery from this inhibition required repeated applications of NMDA alone and was speeded by holding the membrane potential at positive voltages. Identical to MK-801, (+) N-methyl IDDC (10 uM) inhibited the NMDA current in a use-dependent and voltage-dependent manner. Serial applications evoked progressively smaller currents. Inhibition by (+) N- methyl IDDC was reversed only with prolonged or repeated application of NMDA The rate of recovery from blockade by (+) N-methyl IDDC was somewhat more rapid than the rate of recovery of responses following MK-801. This observation is consistent with the observation that (+) N- methyl IDDC has a lower affinity than MK-801 for the PCP receptor. Example 7: In Vitro Neurotoxidty Assay Dissociated rat hippocampal cultures were prepared using a modification of the method of Huettner and Baughman [Huettner, J.E. and Baugham, R.W., /. Neuroscl 6:3044-3060 (1986)]. The cortices were removed from 1-3 day post-natal rats (Sprague-Dawley) that had been anesthetized with chloral hydrate, and the hippocampi were dissected out and placed in Cl ' free dissociation medium supplemented with 1 mM kynurenic add and 10 mM MgS0 4 (Choi, D.W., /. Neuroscl 7:369-379 (1987)). The hippocampi were washed in the dissociation medium, then incubated for 2x20 minutes at 37°C in dissociation medium containing 10 units ml of Papain (Worthington). After the enzyme treatment, the tissue was incubated for three 5-minute periods at 37°C with 10 mg/ml trypsin inhibitor (Sigma type H-0). The cells were dissociated by trituration in growth medium and plated as 0.15 ml droplets of cell suspension onto the center of 35 mm Primaria (Falcon) dishes that had been stamped with a labeled 26 x 26 grid of approximately 0.64 cm 2 total area using a Mecanex BB form (WPI, New Haven, CT) and coated with poly-D-lysine and laminin (Collaborative Research). The cell density was between 2.5 and 4.0 x IO 5 cells per dish. The growth medium was Eagles minimum essential media (MEM, Earle's salts) supplemented with 5% fetal bovine serum (CCL), 5% defined supplemented calf serum (HyClone), 50 mM glucose, 50 units ml pemcilhn/sfreptomycin and MITO+ serum extender (Collabora¬ tive Research). The cells were maintained at 37°C in a humidified 4.5% C0 2 atmosphere. Cells were left for 12-14 hours to attach to the plate surface, then 1.5 mis of growth medium was added to each dish, 1 ml removed and replaced with a further 1 ml of fresh medium. This process removed most of the cell debris and unattached cells. The area of cell attachment and proliferation did not significantly extend beyond the treated central area. After 2-4 days in culture, non-neuronal cell division was arrested by a 2-3 day exposure to 5 uM cytosine arabinoside. The cells were maintained in a medium that was similar to the growth medium but without the fetal bovine serum. The medium was changed on a weekly schedule, replacing two-thirds the volume with fresh medium. The only glutamate present in the media was that contained in the calf serum which gave a final concentration of 12 uM. Before treatment, sister cultures were examined under phase- contrast microscopy to ensure that the cultures were of a similar density. Exposure to glutamate was carried out at 32-34°C in a HEPES-buffered "control salt solution" (CSS) similar to that reported in Choi, D.W., Maulicci-Gedde, M. and Viriegstein, A.R., /. Neuroscl 7:257-268 (1987), but with 10 mM HEPES substituted for Tris-HCl and buffered for pH 7.4 at 34°C. The cultures were washed twice with CSS and then incubated for 5 minutes in CSS containing 1 uM glycine and the compound to be tested (the controls had 1 uM glycine only). Glycine was included since it has been shown to potentiate the effects of glutamate at the NMDA site [Johnson, J.W. and Ascher, P., Nature 325:529-530 (1987)] and the preincubation with the test drugs enhances the neuroprotection activity (Finkbeiner, S.C., etal, Proc. Natl Acad Sci. USA 55:4071*4074 (1988)). CSS containing 1 uM glycine plus drug and a known concentration of glutamate (0-1000 uM) were added by triple exchange and the cultures were incubated for 5 minutes. The cultures were washed four times with CSS and then with medium before being placed in the incubator overnight. Cultures were removed from the incubator the next day, washed twice with CSS and treated for 5 minutes with 0.4% Trypan Blue, a dye that is only taken up by dead and dying cells. The cultures were washed three times and the surviving cells counted in the grid area using phase contrast microscopy. Cell survival was normalized as a percentage of the highest cell count, and the results plotted against glutamate concen- tration. Cultures not exposed to glutamate generally had between 4500 and 5500 surviving cells in the grid area. (±)-IDDC was tested for its neuroprotedfve properties against a range of glutamate concentrations. Figure 1 depicts a graph showing the in vitro neuroprotective effect of (±)-IDDC, (+)-IDDC, N-methyl IDDC and a control sample on rat hippocampal cells treated with various concentrations of glutamate. As illustrated in Figure 1, cultures tested with 5 uM (±)-IDDC, 5 uM (+)-IDDC and 10 uM N-methyl IDDC exhibited enhanced cell survival when compared to control values. Example 8: In Vivo Neurotcoάάty Assay The experimental model of McDonald, J.W., et al, supra, was employed with the single alteration in protocol of an intraperitoneal injection of the test compound 15 minutes following, rather than preceding, the cerebral NMDA injection. As shown in Figure 2, (+)- IDDC was found, in dosages ranging from about 0.30 to 60 μMol/kg of body weight, to protect against the lesions caused by NMDA injection. These observations on the in vitro and in vivo neuroprotective properties of IDDC are consistent with its affinity for the PCP binding site in brain and the inhibition of the NMDA current described above. Example 9: The preparation of Aiyl-substituted IDDC derivatives The following is an experimental description of syntheses of some racemic substituted IDDC's and one optically active IDDC derivative. The synthesis for each substituted IDDC began with a Friedel-Crafts reaction of an appropriate phenylacetyl chloride with an appropriate aromatic substrate. The resulting desoxybenzoin was then converted to its methyl oxime ether using the method of Sing (Sing, P.J., Org. Chem. 44:843 (1979)). The syn- and anti- isomers were usually not separated, but reacted together with borane-tetrahydrofuran complex to give the corresponding amines, according to the method of Feuer and Braunstein. (Feuer et al, J. Org. Chem. 34:1817 (1969)). The resulting amines were alkylated with bromoacetaldehyde diethylacetal in DMF. The resulting acetals were cyclized to the corresponding IDDC's using neat perchloric or sulfuric add, according to the method of Suzuki et al (Suzuki et al, H. Chem. Pharm. BuH 34:1888 (1986)). The N-methyl derivative of 3-bromo-IDDC was prepared. Maleate salts were prepared from 3-chloro- and 3-bromo-IDDC and maleic acid. See Scheme II for the synthetic outline and compound numerals, which are referred to throughout the Experimental section, and numbering for IDDC. -41- Scheme HI X=H. Y=OMe 1 Cl, H 2 Br. H 3 H. CJ 4 OMe. H 5 X=H. Y=OMe 6 CI. H 7 Br. H 8 H. CJ 9 OMe, H 10 X=H. Y=O e 16 X=H. Y=OMe 21 Ci, H 17 Cl. H 22 Br. H 18 Br. H 23 H. 19 H. Cf 24 OMe. H 20 OMe. H 25 a A!CI 3 ; b CH 3 ONH 2 ΗCl. pyridine; c BH 3 THF; d BrCH2CH(OEt) 2 , K 2 C0 3f DMF; e HC!0 4 orH 2 S0 4 General. All reactions were carried out in glassware that had been oven dried. Except where noted, solvents were reagent grade and used as received. NMR spectra were obtained on a General Electric QE 300 instrument, and the chemical shifts are reported in delta units using residual solvent proton signals as the reference. Infrared spectra were obtained on a Nicolet 5DXB FT-IR spectrometer as 5% solutions in the indicated solvent; absorptions are classified as strong (s), medium (m), or weak (w). "Flash" chromatography was performed under positive air pressure with Davisil sihca gel (grade 643, 200-425 mesh, 150 angstroms) as the stationary phase. Analytical thin layer chromatography was performed on aluminum-backed sihca gel 60 F^ plates with a fluorescent indicator, and visualization was effected with an ultraviolet lamp. All products were chromatographically homogeneous. Mass spectroscopy was carried out in the electron ionization mode. A. Synthesis of (±) 7-Methαy-IDDC l-(4-Metho^phenyl)-2-phenyl*-l-ethanone (1). To a suspension of aluminum chloride (1.47 g, 11.0 mmol) in 40 ml methylene chloride (40 ml) under nitrogen was added anisole (130 g, 12.0 mmol, dried over molecular sieves). To the resulting light red solution was added phenylacetyl chloride (1.70 g, 11.0 mmol, prepared in 69% yield from phenylacetic add and phosphorous trichloride) as a solution in 15 ml methylene chloride over a period of 30 minutes. The resulting light orange solution was refluxed for four hours, and after cooling poured into 100 ml ice water. The layers were separated and the organic phase washed with water (1x30 ml), 10% NaOH (1x30 ml), water (1x30 ml), and brine (1x30 ml), and dried over sodium sulfate. Concentration in vacuo afforded a white crystalline sohd, which was purified by column chromatography on neutral alumina (20 g, activity I) using 3:1 benzene/ethyl acetate as eluant to afford the ketone as 2.34 g of a white crystalline solid, a portion of which was recrystallized from light petroleum ether (94% yield): m.p. 70.5-72.0°C (lit. m.p. 77°C; Schneider, M.R. et al, J. Med. Chem. 25:1070 (1982)); R f 0.41 (benzene/ethyl acetate 9:1); IR (CDC1 3 ) 3068 (w), 3031 (w), 2970 (w), 2940 (w), 2844 (w), 1675 (s), 1602 (s), 1578 (m), 1512 (m), 1324 (m), 1263 (s), 1173 (s), 1033 (m); Η NMR (CDCI 3 ) 8.03 (d, J=8.8 Hz, 2H), 7.3 (m, 5H), 6.95 (d, J=8.8 Hz, 2H), 4.26 (s, 2H), 3.88 (s, 3H). a solution of l-(4-methoxyphenyl)-2-phenyl-l-ethanone (1, 1.200g, 5.30 mmol) in pyridine (17.0 ml, dried over molecular sieves) under nitrogen was added methoxylamine hydrochloride (0.664 g, 7.96 mmol). The resulting colorless suspension was stirred at room temperature overnight The pyridine was removed in vacuo with heating, and the residual solids were stirred with ether (75 ml) and filtered. The filtrate was concentrated in vacuo to afford a pure mixture of the two geometric isomers as 1.311 g of a colorless, cloudy syrup (96% yield): R f 0.46, 032 (benzene); IR (CDCI 3 ) 3065 (w), 3005 (w), 2963 (w), 2939 (m), 2902 (w), 2822 (w), 1608 (m), 1514 (m), 1495 (m), 1465 (m), 1454 (m), 1439 (m), 1253 (s), 1179 (m), 1049 (s), 1033 (m); low resolution mass spec. 255 (M + , 100), 223 (34), 208 (20), 133 (23), 91 (56). A 210 mg sample of the isomer mixture was subjected to flash chromatography on 25 g sihca gel using benzene as eluant The less polar isomer was isolated pure as 120 mg of a clear, pale yellow syrup: X H NMR (CDC1 3 ) 7.67 (d, J=8.8 Hz, 2H), 7.3 (m, 5H), 6.90 (d, J=8.8 Hz, 2H), 4.19 (s, 2H), 4.08 (s, 3H), 3.82 (s, 3H). The more polar isomer was isolated as 66 mg of a cloudy, pale yellow syrup: ~ H NMR (CDC1 3 ) 738 (d, J=8.8 Hz, 2H), 7.25 (m, 5H), 6.86 (d, J=8.8 Hz, 2H), 3.96 (s, 3H), 3.88 (s, 2H), 3.80 (s, 3H). l-Amino-l-(4-methoxyphenyl)-2-phenylethane (11). To a solution of a mixture of syn- and anti-oxime isomers 2, (1.31 g, 5.13 mmol) in THF (50 ml, freshly distilled from sodium/benzophenone ketyl) was added borane-tetrahydrofuran complex (1.0 M in THF, 25.6 ml, 25.6 mmol) via syringe at room temperature under nitrogen. The resulting clear colorless solution was refluxed for 3 1/4 hours, and cooled in an ice water bath. Water (40 ml) was carefully added, followed by 20% NaOH (40 ml). The resulting bi-phasic solution was refluxed with vigorous magnetic stirring overnight, and allowed to cool to room temperature. Hexanes (50 ml) were added, and the layers separated. The aqueous portion was extracted with hexanes (1x50 ml). The combined organic portions were dried over potassium carbonate and concentrated in vacuo to a cloudy colorless syrup, which was purified by column chromatography on neutral alumina (activity I, 35 g) using CHC ethyl acetate (1:1) and then pure CHC1 3 as eluant to give the amine as 1.024 g of a clear, colorless syrup (88% yield): R f 0.45 (4% Et_NH in CHC1 3 ); IR(CDC1 3 ) 3155 (m), 3033 (w), 2926 (m), 2835 (w), 1819 (w), 1794 (w), 1611 (m), 1514 (s), 1464 (m), 1377 (m), 1250 (s), 1179 (m); Η NMR 6735-7.17 (m, 7H), 6.90 (d, J=8.4 Hz, 2H), 4.18 (dd, J=8.6, 5.1 Hz, 1H), 3.83 (s, 3H), 3.01 (dd, J=13.2, 4.9 Hz, 1H), 2.83 (dd, J=13.2, 8.8 Hz, 1H), 1.46 (s, 2H); low resolution mass spec. 227 (M + , 2), 224 (6), 211 (19), 126 (100), 121 (16), 109 (52), 91 (47). l-(N-ethyI-(2,2-ethoxy))-aι__ino-l-(4-methoxy-ρhenyl)-2-phenyl ethane (16). To a solution of the amine 11 (997 mg, 439 mmol) in 40 ml DMF (dried over molecular sieves) under nitrogen was added potassium carbonate (2.43 g, 17.6 mmol) and bromoacetaldehyde diethylacetal (2.16 g, 11.0 mmol, distilled) at room temperature. The resulting clear colorless suspension was heated at 100°C for 19 hours. After cooling to room temperature, 10% NaOH (150 ml) was added. The resulting pale yellow cloudy mixture was extracted with methylene chloride (3x50 ml). The combined organic extracts were washed with water (2x50 ml) and brine (1x50 ml), and dried over potassium carbonate. Concentration in vacuo with heating afforded a red-yellow syrup, which was purified by flash chromatography on 35 g sihca gel using 3:1 hexanes/ethyl acetate as eluant The acetal 16 was obtained as 965 mg of a pale yellow syrup (63% yield): R f 030 (hexanes/ethyl acetate 2:1); IR (CDC1 3 ) 3328 (w), 3062 (w), 3031 (w), 2977 (m), 2934 (m), 2910 (m), 2838 (m), 1614 (m), 1584 (w), 1512 (s), 1457 (m), 1245 (s), 1173 (m), 1130 (s), 1057 (s); Η NMR (CDC1 3 ) 5731-7.14 (m, 7H), 6.87 (d, J * -=8.6 Hz, 2H), 4.52 (t, J=5.6 Hz, 1H), 3.82 (s, 3H), 3.8 (m, 1H), 3.65-334 (m, 4H), 2.92 (m, 2H), 2.52 (m, 2H), 1.68 (s, 1H), 1.10 (q, J=7.2 Hz, 6H); low resolution mass spec. 344 (M + +l, 8), 252 (100), 211 (50), 206 (61), 91 (23). 7-Methσxy-IDDC (21). A 5 ml round bottom flask was charged with the acetal 16 (310 mg, 0.903 mmol) under nitrogen. Perchloric acid (69%, 1.59 ml, 18.1 mmol) was added by syringe. The resulting red-yellow syrup was stirred at room temperature for 49 hours, and quenched with ice and 10% NaOH (pH>10). Extraction with methylene chloride (3x10 ml) afforded, after combination of the extracts, an organic solution that was washed with brine (1x15 ml) and dried over sodium sulfate. Concentration in vacuo afforded a dark golden syrup that was purified by flash chromatography on 12 g sihca gel using an elution gradient of ethyl acetate to 15% methanol/ethyl acetate (the methanol contained 1% concentrated ammonium iiydroxide). The product was isolated as 110 mg of a clear, colorless syrup (48% yield): R f 0.10 (ethyl acetate/methanol 4:1): IR (CDC1 3 ) 3352 (w), 3063 (w), 3019 (w), 2916 (m), 2831 (w), 1490 (s), 1450 (m), 1283 (m), 1249 (s), 1134 (m); X H NMR (CDC1 3 ) 5733-7.01 (m, 5H), 6.80 (d, J=2.4 Hz, 1H), 6.76 (d, J=2.7 Hz), 6.73 (d, J=2.7 Hz, 1H over 6.76-6.73), 4.32 (t, J=3.6 Hz, 1H), 3.87 (d, J=4.1 Hz, 1H), 3.79 (s, 3H), 3.65 (dd, J=11.7, 1.1 Hz, 1H), 3.47 (dd, J=17.5, 3.8 Hz), 3.32 (dd, J=11.5, 4.6 Hz), 3.21 (dd, J=17.5, 3.3 Hz, 1H), 2.2 (br s, 1H); 13 C NMR (CDC1 3 ) 159.1, 142.8, 135.5, 132.6, 131.5, 128.0, 126.8, 126.0, 111.9, 111.6, 55.4, 54.5, 50.6, 47.5, 42.3; EIHRMS 251.1313 (calculated for C 18 H 17 ON 251.1311). B. Synthesis of (±) 3-C oro-IDDC 4-Chloroρhenylacetyl chloride. A mixture of 4-chlorophenylacetic add (5.00 g, 29.3 mmol) and phosphorous trichloride (2.01 g, 14.7 mmol) in a round bottom flask under nitrogen was heated to 95 °C, resulting in gas evolution and a cloudy, pale yellow solution. A yellow predpitate appeared after 30 minutes, and after another 30 minutes the precipitate had congealed into an amorphous yellow sohd. The remaining liquid was decanted. The sohd was rinsed with methylene chloride (2x5 ml), and the rinses were combined with the decanted liquid. Concentration via rotary vaporation afforded a syrupy pale yellow residue, which was purified by vacuum distillation (short path). The add chloride was isolated as 3.371 g of a clear colorless liquid (61% yield): b.p. 52-53 °Q0.020 torr; X H NMR (CDC1 3 ) 7.30 (dd, J=44.0, 8.1 Hz, 4H), 4.14 (s, 2H). 2-(4-C3hlorophen^)-l-pheιr^-l-eflιanone (2). To a suspension of aluminum chloride (1.27 g, 9.52 mmol) in 30 ml dry benzene under nitrogen was added at room temperature 4-chlorophenylacetyl chloride (1.80 g, 9.52 mmol) over a period of 30 minutes as a solution in 10 ml benzene. The resulting clear, pale yellow solution was refluxed for six hours. After cooling to room temperature, the resulting grey-brown solution was poured into 100 ml ice water. The layers were separated and the aqueous portion extracted with benzene (1x20 ml). The combined organic portions were washed with water (2x30 ml), 10% NaOH (1x30 ml), water (1x30 ml), and brine (1x30 ml), and dried over magnesium sulfate. Filtration through Celite afforded, after concentration in vacuo, 2.18 g of the ketone as a white crystalline solid (99% crude yield): R f 0.46 (benzene); Η NMR (CDC1 3 ) 8.03 (d, J=7.2 Hz, 2H), 7.63-7.21 (m, 7H), 4.29 (s, 2H). A portion (ca. 1 g) of the ketone was reciystallized from 75 ml boiling pet ether/ethanol (5:1) to give a fluffy white crystalline solid: m.ρ. 132.5-134.0°C (lit. m.p. 135-136°C; Loeshorn, CH. et al, J. Org. Chem. 48:4409 (1983)). 2-(4-C_ιlorophenyl)-l-phenyl-l-ethanone-0-methyl oxime (7). To a solution of 2-(4-chlorophenyl)- 1-phenyl-l-ethanone (2, 1.93 g, 8.37 mmol) in 25 ml pyridine (dried over molecular sieves) under nitrogen was added at room temperature methoxylamine hydrochloride (873 mg, 10.5 mmol). The resulting slightly cloudy, pale orange mixture was stirred at room temperature overnight The pyridine was removed in vacuo with heating. The residual solids were stirred with ether (60 ml), isolated by filtration, and discarded. The filtrate was dried over sodium sulfate, and concentrated in vacuo to give a mixture of the oxime geometrical isomers as 2.00 g of a clear, pale yellow syrup (92% yield). * Η NMR showed the isomers to be formed in a 5:3 ratio: R f 0.64, 0.50; IR (CDC1 3 ) 3068 (w), 2940 (m), 2819 (w), 1602 (w), 1493 (s), 1442 (m); Η NMR (CDC1 3 ) 7.63 (m, 2H), 737-7.11 (m, 11.5 H), 4.12 (s, 2H), 4.05 (s, 3H), 3.91 (s, 1.6H), 3.82 (s, 1.2H); low resolution mass spec. 259 (M + , 8), 227 (100), 192 (28), 165 (18), 134 (12), 125 (62), 119 (37). 2-(4-Chlorophenyl)-l-phenyl-l-amino ethane (12). To a solution of oxime geometric isomers 7 (840 mg, 3.23 mmol) in 30 ml dry THF (freshly distilled from sodium/benzophenone ketyl) under nitrogen was added borane-tetrahydrofuran complex (1.0 M in THF, 16.2 ml, 16.2 mmol) by syringe at room temperature. The resulting pale yellow solution was refluxed overnight, and cooled in an ice bath. Water (25 ml) was carefully added to quench, followed by 20% NaOH (25 ml). The resulting bi-phasic solution was refluxed with vigorous magnetic stirring overnight After cooling to room temperature, hexanes (40 ml) were added, and the layers were separated. The aqueous portion was extracted with hexanes (1x40 ml). The combined organic portions were dried over potassium carbonate and concentrated in vacuo to a cloudy, pale yellow syrup. This syrup was purified by column chromatography on 18 g neutral alumina (activity I) using chloroform as eluant to afford the amine as 455.6 mg of a colorless, slightly cloudy syrup (61% yield): R f 036 (5% Et,NH/CHCl 3 ); IR (CDC1 3 ) 3376 (w), 3316 (w), 3031 (w), 2928 (m), 2856 (w), 1602 (m), 1493 (m), 1451 (m); Η NMR (CDC1 3 ) 5738-7.28 (m, 5H), 7.26 (d, J=83 Hz, 2H), 7.09 (d, J=83 Hz, 2H), 4.18 (dd, J=83, 5.4 Hz, IH), 2.98 (dd, J=13.4, 5.4 Hz, IH), 2.84 (dd, J=13.4, 8.4 Hz), 1.50 (br s, 2H); low resolution mass spec. 232 (M + , 22), 215 (37), 125 (54), 106 (100), 89 (49), 79 (100). l-(N-ethyIr(2^-^fto_y))-aιιmo-^ (17). To a solution of the amine 12 (442 mg, 1.91 mmol) in 17 ml DMF (dried over molecular sieves) was added potassium carbonate (1.053 g, 7.62 mmol) and bromoacetaldehyde diethylacetal (751 mg, 3.81 mmol, distilled) at room temperature under nitrogen. The resulting clear colorless suspension was heated at 100°C for 20 hours. After cooling to room temperature, the reaction mixture was mixed with 10% NaOH (60 ml). The resulting yellow cloudy mixture was extracted with methylene chloride (3x30 ml). The combined organic portions were washed with water (1x30 ml) and brine (1x30 ml), and dried over potassium carbonate. Concentration in vacuo with heating afforded an orange liquid that was purified by flash chromatograph on 35 g sihca gel, using 5:2 hexanes/ethyl acetate as eluant The acetal was isolated as 332 mg of a pale orange, clear syrup (50% yield): R, 0.54 (1:1 hexanes/ethyl acetate); IR (CDC1 3 ) 3031 (w), 2977 (m), 2928 (m), 1602 (w), 1493 (m), 1451 (m), 1378 (w), 1130 (m), 1094 (m), 1057 (s); Η NMR (CDC1 3 ) 5734-7.25 (m, 5H), 7.23 (d, J=8.4 Hz, 2H), 7.04 (d, J=8.4 Hz, 2H), 4.52 (t, J=5.6 Hz, IH), 3.81 (t, J=7.0 Hz, IH), 3.58 (m, 2H), 3.42 (m, 2H), 2.90 (d, J=7.0 Hz, 2H), 2.52 (m, 2H), 1.64 (s, IH), 1.13 (dt, J=7.0, 1.3 Hz, 6H); U C NMR (CDC1 3 ) 143.4, 137.5, 132.3, 130.8, 128.5, 127.4, 127.3, 102.1, 64.8, 62.1, 50.0, 44.7, 15.4; low resolution mass spec. 348 (M + , 1), 302 (9), 227 (13), 222 (94), 215 (48), 176 (100), 130 (22), 103 (56). (±) 3-CMoro-IDDC (22). The acetal 17 (208 mg, 0.598 mmol) and perchloric add (1.74 g of a 69% solution, 12.0 mmol) were mixed together at room temperature under nitrogen. The resulting red-brown mixture was stirred at room temperature for 70 hours, followed by quench and basification with ice and 10% NaOH (8 ml). The resulting cloudy mixture was extracted with methylene chloride (3x8 ml), and the combined extracts were washed with brine (1x10 ml) and dried over sodium sulfate. Concentration in vacuo afforded an amber syrup, which was purified by flash chromatograph on 15 g sihca gel using an elution gradient of ethyl acetate to 15% methanol/ethyl acetate (the methanol contained 1% concentrated ammonium hydroxide). 3-Chloro-IDDC was isolated as 119.0 mg of a clear, colorless syrup (76% yield): R f 0.16 (THF): IR (CDC1 3 ) 3352 (m), 3074 (m), 3025 (m), 2922 (s), 2874 (m), 1596 (s), 1487 (s), 1457 (m), 1421 (m), 1372 (m), 1251 (m), 1179 (m), 1106 (s); Η NMR (CDC1 3 ) 57.27-7.19 (m, 5H), 7.09 (dd, J=8.2, 2.2 Hz, IH), 6.97 (d, J=8.2 Hz, IH), 4.31 (t, J=3.7 Hz, IH), 3.86 (d, J=4.1 Hz, IH), 3.64 (dd, J=11.7, 1.1 Hz, IH), 3.45 (dd, J=17.6, 3.85 Hz, IH), 3.31 (dd, J=11.5, 4.85 Hz, IH), 3.17 (dd, J=17.6, 3.4 Hz, IH), 2.40 (s, IH); "C NMR (CDC1 3 ) 144.6, 140.8, 140.1, 133.8, 132.8, 1313, 127.7, 127.4, 127.2, 126.7, 125.6, 125.0, 54.8, 50.5, 46.6, 41.2; EIHRMS 255.0825 (255.0816 calculated for C 16 H 14 NC1). (±) 3-Chloro-IDDC maleate. To a solution of 3-chloro-IDDC (50.0 mg, 0.196 mmol) in 0.80 ml absolute ethanol was added under nitrogen maleic add (22.7 mg, 0.196 mmol, Aldrich, used as is) as a solution in 0.30 ml ethanol at room temperature. The resulting pale brown solution was allowed to stand at room temperature for 24 hours. Addition of pentane caused, after standing overnight, the formation of a white-orange sohd. This sohd was re-precipitated by dissolving in ca. 2 ml boiling 1:1 benzene/ethanol, followed by pentane addition after cooling to room temperature. The maleate salt was isolated as 35.0 mg of a white sohd (48% yield): m.p. 153.7-156.0 °C; Η NMR (MeOH-d 4 ) 57.47-735 (m, 5H), 7.21 (dd, J=8.2, 2.1 Hz, IH), 7.10 (d, J=83 Hz, IH), 6.24 (s, 2H), 4.99 (t, J=3.0 Hz, IH), 4.26 (d, J=4.2 Hz, IH), 3.87 (d, J=12.5 Hz, IH), 3.69 (dd, J=18.7, 3.0 Hz, IH), 3.53 (dd, J=12.5, 4.6 Hz, IH), 333 (dd, J=18.4, 3.0 Hz, IH). C. Synthesis of (±) 3-Bromo-IDDC 4-Bromσphenylacεtyl chloride. A mixture of 4-bromophenylacetic add (6.00 g, 27.9 mmol, Aldrich, used as is) and phosphorous trichloride (1.92 g, 14.0 mmol, Aldrich, used as is) was heated under nitrogen to 100 °C. After one hour, the resulting cloudy liquid was decanted from an amorphous yellow sohd. The sohd was rinsed with methylene chloride (2x5 ml), and the rinses were combined with the decanted liquid. Rotary evaporation of the resulting solution afforded a slightly yellow syrup, which was purified by vacuum distillation (short path) to afford the add chloride as 4.65 g of a clear, very pale yellow liquid (71% yield): b.p. 56.5- 59.5° O.025 torr; Η NMR 5732 (d, J=8.4 Hz, 2H), 7.17 (d, J=8.4 Hz, 2H), 4.13 (s, 2H). 2-(4-Bromophenyl)-l-phenyl-l-ethanone (3). To a suspension of aluminum chloride (2.64 g, 19.8 mmol) in dry benzene (40 ml) was added a solution of 4-bromophenylacetyl chloride (4.63 g, 19.8 mmol) in 15 ml benzene over a period of 25 minutes under nitrogen. The resulting dark yellow solution was refluxed for six hours, and cooled to room temperature. Ice water (100 ml) was added, and the layers separated. The aqueous layer was extracted with benzene (1x50 ml). The combined organic portions were washed with water (2x60 ml), 10% NaOH (1x60 ml), water (1x60 ml), and brine (1x60 ml), and dried over magnesium sulfate. After filtration, concentration of the filtrate in vacuo afforded the ketone as 5.06 g of a white microcrystalline sohd (93% yield). NMR indicated good purity. A portion was reciystallized from boiling petroleum ether/efhanol to give the ketone as colorless plates: m.p. 147.5- 149.0°C (lit m.p. 146-147°C; Huttel, R. et al, J. Chem. Ber. 93:1433 (I960)); -H NMR 58.02 (d, J=7.1 Hz, 2H), 7.63-7.46 (m, 5H), 7.16 (d, J=83, 2H), 4.27 (s, 2H). 2 ^ (4-Bromophenyl)-l-phenyI-l-ethanone-0-methyl oxime (8). To a solution of 2-(4-bromophenyl)- 1-phenyl-l-ethanone (3, 4.55g, 16.5 mmol) in 65 ml pyridine (dried over molecular sieves) was added methoxylamine hydrochloride (1.66 g, 19.8 mmol, Aldrich, used as is) at room temperature. The resulting yellow-orange, slightly turbid mixture was stirred at room temperature for 20 hours, and the pyridine was removed in vacuo with heating. The residue was stirred with ether (60 ml), followed by filtration. The filtrate was dried over sodium sulfate, and concentrated to a syrupy orange residue. This residue was purified by column chromatography on 20 g alumina (neutral, activity I) using benzene as eluant The mixture of geometric isomers was isolated as 4.953 g of a clear, pale amber syrup (98% yield). * H NMR indicated that the isomers were formed in a 1.65:1 ratio: R f 0.57, 0.46 (benzene): IR (CDC1 3 ) 3068 (w), 2971 (m), 2940 (m), 2898 (m), 2819 (m), 1602 (w), 1487 (s), 1463 (m), 1439 (m), 1403 (m), 1330 (m), 1191 (w), 1106 (m), 1072 (m), 1047 (s), 1022 (m), 1013 (s); Η NMR (CDC1 3 ) 57.64 (m, 2H), 7.43-7.25 (m, 8.5 H), 7.10 (2d, J=8.4 Hz, 3H), 4.11 (s, 2H), 4.05 (s, 3H), 3.92 (s, 1.8H), 3.81 (s, 1.25H); low resolution mass spec. 305 (M + , 5.8), 303 (M + , 5.8), 273 (100), 271 (100), 192 (44), 171 (45), 169 (45), 165 (34), 135 (18), 119 (67), 103 (44). l-Amino-2-(4-bromophenyl)-l-phenylethane (13). To a solution of the mixture of oxime isomers 8 (4.92 g, 16.2 mmol) in 75 ml THF (freshly distilled from sodium benzophenone ketyl) under nitrogen was added borane-tetrahydrofuran complex (1.0 M in THF, 55.0 ml, 55.0 mmol) by syringe at room temperature. The resulting pale orange solution was brought to reflux and held there for 16 hours. With cooling by an ice bath, water (125 ml) was carefully added to quench, followed by 20% NaOH (125 ml). The resulting biphasic solution was refluxed with vigorous magnetic stirring overnight After cooling to room temperature, hexanes (60 ml) were added and the layers were separated. The aqueous portion was extracted with hexanes (2x50 ml). The combmed organic portions were dried over potassium carbonate and concentrated in vacuo to a cloudy, colorless syrup. This syrup was purified by column chromatography on 20 g neutral alumina (activity I) using a 20% ethyl acetate-hexanes to 4% diethylamine-chloroform elution gradient The amine 13 was isolated as 3.985 g of a clear, colorless syrup (89% yield): R f 0.18 (2% diethylamine in CHC1 3 ); Η NMR (CDC1 3 ) 57.41 (d, J=8.2 Hz, 2H), 735-7.28 (m, 5H), 7.03 (d, J=8.2 Hz, 2H), 4.18 (dd, J=8.2, 5.3 Hz, IH), 2.97 (dd, J=133, 5.3 Hz, IH), 2.83 (dd, J=133, 83 Hz, IH), 1.45 br s, 2H); low resolution mass spec.277 (M + , 1.5), 275 (M + , 1.5), 261 (2.2), 259 (2.2), 171, (4.5), 169 (4.5), 106 (100), 79 (45). l-(N-efty_r(-_ -e£hc£-y))-am (18). To a solution of the amine 13 (3.97 g, 14.4 mmol) in DMF (125 ml, dried over molecular sieves) under nitrogen was added potassium carbonate (7.96 g, 57.6 mmol) and bromoacetaldehyde diethylacetal (7.09 g, 36.0 mmol, distilled) at room temperature. The resulting clear colorless mixture was heated to 100 °C and held there for 16 hours. After cooling to room temperature, 10% NaOH (225 ml) was added. The resulting cloudy mixture was extracted with methylene chloride (3x85 ml). The combined extracts were washed with water (1x100 ml) and brine (1x100 ml), and dried over potassium carbonate. Concentration in vacuo with heating afforded a clear red syrup, which was purified by flash chromatography on 45 g sihca gel, using a hexanes to 20% ethyl acetate hexanes elution gradient The acetal 18 was isolated as 3.709 g of a red-orange syrup (65% yield): R f 0.312 (hexanes/ethyl acetate 2:1); IR (CDC1 3 ) 3322 (w), 3068 (w), 3031 (w), 2977 (m), 2928 (m), 1487 (s), 1451 (m), 1378 (m), 1130 (s), 1063 (s), 1015 (m); Η NMR (CDC1 3 ) 5739-7.22 (m, 7H), 6.98 (d, J=8.35 Hz, 2H), 4.52 (t, J=5.6 Hz, IH), 3.81 (t, J=7.0 Hz, IH), 3.58 (m, 2H), 3.43 (m, 2H), 2.89 (d, J=7.0 Hz, 2H), 2.53 (m, 2H), 1.63 (br s, IH), 1.13 (dt, J * =7.0, 1.1 Hz, 6H); low resolution mass spec. 394 (M+l, 60), 392 (M+l, 61), 348 (26), 346 (27), 261 (11), 259 (11), 222 (97), 176 (100). (±) 3-Bromo-IDDC (23). To the neat acetal 18 (365.0 mg, 0.9303 mmol) at room temperature under nitrogen was added perchloric add (2.71 g of a 69% solution, 18.6 mmol) by syringe. The resulting cloudy grey-brown mixture was stirred at room temperature for 27 hours. Cracked ice was added, followed by 10% NaOH (10 ml) so that the ρH> 10. The resulting cloudy white mixture was extracted with methylene chloride (3x10 ml). The combined extracts were washed with brine (1x15 ml) and dried over sodium sulfate. Concentration in vacuo afforded an amber residue, which was purified by flash chromatography on 15 g sihca gel using an ethyl acetate to 10% methanol/ethyl acetate elution gradient (the methanol itself contained 1% concentrated ammonium hydroxide). The product was isolated as 162.4 mg of a clear, very pale brown syrup that solidified upon standing (58% yield): m.p. 87.5-90.0°C; R f 0.26 (ethyl acetate/methanol 4:1); IR (CDC1 3 ) 3352 (w), 3080 (w), 3025 (w), 2922 (m), 2874 (w), 1590 (m), 1481 (s), 1457 (m), 1421 (m), 1372 (w), 1251 (m), 1179 (m), 1112 (m); Η NMR 57.37 (d, J=2.0 Hz, IH), 730-7.15 (m, 5H), 6.90 (d, J=8.2 Hz, IH), 4.30 (t, J=3.7 Hz, IH, 3.84 (d, J=4.5 Hz, IH), 3.62 (d, J=11.2, IH), 3.43 (dd, J=17.6, 3.8 Hz, IH), 3.28 (dd, J=11.5, 4.8 Hz, IH), 3.14 (dd, J * =17.6, 3.4 Hz, IH), 2.10 (s, IH); U C NMR (CDC1 3 ) 145.4, 141.1, 140.5, 134.8, 133.4, 130.9, 129.9, 127.7, 127.5, 126.0, 125.3, 119.6, 55.1, 51.9, 46.8, 41.6; low resolution mass spec. 301 (M + , 15), 300 (16), 299 (M + , 15), 299 (15), 298 (16), 273 (7), 272 (37), 271 (13), 270 (37), 269 (8), 191 (22), 189 (23), 130 (100). (±) 3-Brσmo-IDDC Maleate. To a solution of 3-bromo-IDDC (72.0 mg, 0.240 mmol) in 0.60 ml absolute ethanol under nitrogen was added a solution of maleic add (27.8 g, 0.240 mmol, Aldrich, used as is) in 0.30 ml ethanol at room temperature; 0.20 ml ethanol was used as rinse. The resulting pale brown solution was allowed to stand at room temperature overnight No precipitate was present. Pentane (1 ml) was added, resulting in cloudiness in the solution. After standing overnight, a white precipitate had formed, which was collected as 90.0 mg of small white pebbles after rinsing with dry ether and drying in vacuo (90% yield): m.p. 165.0-167.5 °C; Η NMR (CD 3 OD) 57.53 (d, J=2.0 Hz, IH), 7.48-732 (m, 5H), 7.04 (d, J * =8.3 Hz, IH), 6.24 (s, 2H), 4.98 (t, J=3.6 Hz, IH), 4.25 (d, J=4.5 Hz, IH), 3.86 (d, J=12.4 Hz, IH), 3.66 (dd, J=18.8, 3.3 Hz, IH), 3.53 (dd, J=12.4, 4.85 Hz, IH), 3.28 (dd, J=18.7, 3.2 Hz, IH). D. Synlhesis of (±) N-Methyl-3-bromo-IDDC The procedure of Borch and Hassid was adapted. (Borch et al, J. Org. Chem. 37:1673 (1972)). To a solution of 3-bromo-IDDC (68.1 mg, 0.227 mmol) in acetonitrile (0.50 ml, dried over molecular sieves) at room temperature was added aqueous formaldehyde (37% solution, 0.065 ml, 0.87 mmol). A white sohd formed immediately. Sodium cyanoborohydride (20.0 mg, 0.318 mmol, Aldrich, used as is) was introduced. A mild exofherm was observed, and the sohd gradually dissolved. The resulting cloudy yellow mixture was stirred for 30 minutes, and glacial acetic add (2 drops) was added to bring the pH to ca. 6 (by wet pH paper). Stirring was continued; after 10 minutes more acetic add (2 drops) was added to maintain the pH near neutral. Stirring was continued for 40 more minutes, during which the pH remained constant. The reaction mixture was concentrated in vacuo to a pale yellow residue, which was taken up in methylene chloride (10 ml) and 10% NaOH (5 ml). The layers were separated and the organic layer washed with 10% NaOH (2x10 ml) and brine (1x10 ml), and dried over potassium carbonate. Evaporation of the solvent afforded a white residue, which was purified by preparative thin layer chromatography (1000 micron thickness, sihca gel) using 8% methanol/ethyl acetate as eluant (the methanol contained 1% concentrated ammonium hydroxide). The N-methyl amine was isolated as 49 mg of a clear colorless residue (69% yield): R f 0.36 (ethyl acetate nethanol 4:1); Η (CDC1 3 ) 57.33 (d, J=1.9 Hz, IH), 7.24-7.15 (m, 5H), 6.91 (d, J=8.2 Hz, IH), 3.96 (t, J=3.6 Hz, IH), 3.60 (d, J=3.8 Hz, IH), 3.60 (dd, J=10.8, 1.1 Hz, IH), 3.57 (dd, J=17.4, 4.0 Hz, IH), 2.94 (dd, J=17.5, 3.0 Hz, IH), 2.91 (dd, J=10.7, 4.6 Hz, IH), 2.50 (s, 3H). Low resolution mass spec. 315(M + +1, 17), 314(M + , 23), 313(M + +1, 17), 312(M + , 20), 272(17), 270(18), 192(4.3), 191(16), 190(8.7), 189(20), 144(100), 145(28). E. Synthesis of (±) 7-Chloro-IDDC l-(4-Chlorophenyl)-l-phenyl-l-ethanone (4). The procedure of Newman and Reid was followed. (Newman et al, J. Org. Chem. 23:665 (1958)) To a slurry of aluminum chloride (5.84 g, 43.8 mmol) in chlorobenzene (17.2 ml, 169 mmol, freshly distilled from calcium hydride) was added at room temperature phenylacetyl chloride (6.15 g, 39.8 mmol) via syringe. An exotheπn resulted and the reaction mixture turned orange. The reaction mixture was heated at 70°C for 90 minutes, and poured onto cracked ice. The solid product was solubilized in methylene chloride, and the layers were separated. The aqueous portion was extracted with methylene chloride (30 ml, 2x). The combined organic portions were washed with 10% NaOH (30 ml, lx), water (30 ml, lx) and brine (30 ml, lx), and dried over magnesium sulfate. After filtration through celite, concentration of the filtrate afforded a moist orange sohd. This sohd was reciystallized twice, first from 4:1 ethanol-water and then from absolute ethanol to give the ketone as 3.63 g of a pale orange powder (40% yield): m.p. 85-90°C; Η NMR ((CDC1 3 ) 7.98 (d, J=8.4 Hz, 2H), 7.45 (d, J=8.6 Hz, 2H), 739-7.23 (m, 5H), 4.28 (s, 2H). l-(4-C3ιlorophen) )-2-phenyl-l-ethanone-0-methyl oxime (9). To a solution of l-(4-chlorophenyl)-2-phenyl-l-ethanone (4, 2.71 g, 11.7 mmol) in pyridine (45 ml, dried over molecular sieves) under nitrogen was added methoxylamine hydrochloride (1.273 g, 15.24 mmol, Aldrich, used as is) at room temperature. The resulting pale orange solution was stirred at room temperature overnight The pyridine was evaporated with mild heating. The residual sohds were stirred with ether (75 ml), and the resulting suspension was filtered. Evaporation of the solvent afforded an orange syrup, which was purified by column chromatography on neutral alumina (activity I, 15 g) using benzene as eluant The mixture of syn- and anti-isomers was isolated as 2.781 g of a clear, pale orange syrup (89% yield). NMR analysis indicated that the isomers were formed in a 1.6:1 ratio: R f 0.58, 0.40 (benzene): IR (CDC1 3 ) 3.68 (w), 3031 (w), 2940 (m), 2898 (w), 2819 (w), 1602 (m), 1493 (s), 1451 (m), 1094 (s), 1045 (s), 1015 (m); Η NMR (CDC1 3 ) 57.60 (d, J=8.6 Hz, 2H), 7.40-7.17 (m, 12 H), 4.15 (s, 2H), 4.06 (s, 3H), 3.93 (s, 1.75 H), 3.84 (s, 1.35 H); low resolution mass spec. 261 (M + , 5.6), 259 (M + , 10), 229 (39), 227 (99), 192 (30), 165 (29), 153 (33), 137 (31), 91 (100). l-Amino-l-(4-c_ilorophenyl)-2-phenylethane (14). To a solution of the oxime geometric isomer mixture 9 (2.690 g, 10.36 mmol) in dry THF (50 ml, freshly distilled from sodium benzophenone ketyl) under nitrogen at room temperature was added borane-tetrahydrofuran solution (36.0 ml, 36.0 mmol, 1.0 M solution, Aldrich) by syringe. The resulting very pale orange solution was refluxed for 16 hours, and cooled in an ice bath. Water (80 ml) was added carefully to quench, followed by 20% NaOH (80 ml). The resulting colorless bi-phasic mixture was refluxed overnight with vigorous magnetic stirring. After cooling to room temperature, hexanes (50 ml) were added and the layers separated. The aqueous portion was washed with hexanes (1x30 ml), and the combined organic portions dried over potassium carbonate. Evaporation of the solvent afforded the pure amine as 2392 g of a clear, pale yellow syrup (99% yield): R f 0.22 (5% methanol in CHC1 3 ): IR (CDd 3 ) 3376 (w), 3068 (w), 3031 (w), 2922 (w), 2850 (w), 1602 (m), 1493 (s), 1457 (m), 1409 (w); Η NMR (CDC1 3 ) 57.40- 21 (m, 7H), 7.19 (d, J=8.6 Hz, 2H), 4.21 (dd, J=8.4, 5.2 Hz, IH), 2.98 (dd, J=13.2, 5.2 Hz, IH), 2.81 (dd, J=13.2, 8.6 Hz, IH), 1.43 (s, 2H); low resolution mass spec. 232 (M-l, 5.0), 230 (m-1, 11), 142 (M-91, 37), 140 (M-91, 100), 91 (28). l-(N-et__y^__^-etho * _y))-an-m^ (19). To a solution of l-amino-l-(4-chlorophenyl)-2-phenylethane (14, 2.392 g, 10.32 mmol) in diy DMF (95 ml, dried over molecular sieves) under nitrogen was added bromoacetaldehyde diethylacetal (5.09 g, 25.8 mmol, distilled), and potassium carbonate (5.71 g, 41.3 mmol) at room temperature. The resulting very pale yellow suspension was immersed in an oil bath at 100 °C and held there for 18 hours. After cooling to room temperature, to the resulting pea-green slurry was added 10% NaOH (150 ml). The resulting pale brown mixture was extracted with methylene chloride (3x50 ml); the combined organic extracts were washed with water (1x100 ml) and brine (1x75 ml), and dried over potassium carbonate. After filtration, evaporation of the solvent (with mild heating to drive off the residual DMF) afforded a thick red syrup. This syrup was purified by flash chromatography on sihca gel (38 g) using an elution gradient of hexanes to 15% ethyl acetate/hexanes. The acetal was isolated as 2.486 g of a clear, pale orange syrup (69% yield): R f 0.40 (hexanes/ethyl acetate 2:1); IR (CDCla) 3031 (w), 2983 (m), 2910 (m), 1493 (m), 1457 (m), 1378 (m), 1124 (m), 1094 (s), 1057 (s); Η (CDC1 3 ) 5732-7.21 (m, 7H), 7.12 (d, J=6.7 Hz, 2H), 4.50 (t, J=5.6 Hz, IH), 3.83 (dd, J=7.5, 6.6 Hz, IH), 3.62- 3.49 (m, 2H), 3.49-334 (m, 2H), 2.95-2.80 (m, 2H), 2.58-2.42 (m, 2H), 1.67 (s, IH), 1.11 (q, J=6.7 Hz, 6H); low resolution mass spec. 350 (M+l, 3.4), 348 (M+l, 9.0), 304 (4.5), 302 (13), 258 (30), 256 (80), 217 (18), 215 (51), 212 (36), 210 (92), 125 (46), 103 (100), 91 (29). 7-CMoro-IDDC (24). To the neat acetal 19 (145.4 mg, 0.4180 mmol) at room temperature was added concentrated sulfuric add (820 mg, 8.36 mmol). The resulting red mixture was stirred at room temperature for 40 hours. Cracked ice was added, followed by 10% NaOH until pH>10. The resulting cloudy mixture was extracted with methylene chloride (3x8 ml). The combined organic extracts were washed with brine (1x20 ml), and dried over potassium carbonate. Evaporation of the solvent afforded a dark golden syrup, which was purified by flash chromatography on sihca gel (3.2 g) using an elution gradient of ethyl acetate to 15% methanol/ethyl acetate (the methanol itself was 1% concentrated ammonium hydroxide). The product was isolated as 29.9 mg of a clear, pale yellow syrup (31% yield): R f 0.19 (ethyl acetate-methanol 4:1); IR (CDCI 3 ) 3352 (w), 3062 (w), 3019 (m), 2922 (s), 1874 (m), 1602 (m), 1578 (w), 1499 (m), 1481 (s), 1451 (m), 1415 (m), 1269 (w), 1179 (w), 1082 (m); Η NMR 57.25-7.04 (m, 7H), 4.33 (t, J=3.6 Hz, IH), 3.88 (d, J-4.4 Hz, IH), 3.66 (dd, J=11.4, 1.0 Hz, IH), 3.49 (dd, J=17.6, 3.8 Hz, IH), 3.31 (dd, 1=11.4, 4.7 Hz, IH), 3.20 (dd, J=17.6, 3.4 Hz, IH), 2.06 (s, IH); --C NMR (CDCI 3 ) 143.2, 142.3, 138.8, 135.1, 132.7, 131.4, 128.0, 127.0, 126.8, 1263, 126.1, 125.7, 54.6, 50.5, 46.9, 41.7. Low resolution mass. spec. 257(M+1, 12), 256(M, 18), 255(M+1, 33), 254(M, 30), 228(25), 226(61), 191(29), 189(25), 166(32), 164(100). F. Synthesis of (±) 3-Methσxy-IDDC 2-(4-MethαxyphenyI)-l-phe_ιyl-l-ethanσne (5). To a suspension of aluminum chloride (2.71 g, 20.3 mmol) in benzene (55 ml, dried over sodium) under nitrogen was added dropwise a solution of 4- methoxyphenylacetyl chloride (3.753 g, 20.33 mmol, prepared in 42% yield from 4-methoxyρhenylacetic add and phosphorous trichloride) in 20 ml benzene over a period of 30 minutes at room temperature. The resulting slightly cloudy, pale brown mixture was refluxed for four hours, and poured into 150 ml ice water. The layers were separated and the aqueous phase extracted with benzene (1x50 ml). The combined organic portions were washed with water (1x75 ml), 10% NaOH (1x75 ml), water (1x75 ml), and brine (1x75 ml), and dried over magnesium sulfate. Following filtration through Celite, the filtrate was evaporated to 2.60 g of pale yellow plates (56% crude yield). This sohd was reciystallized from boiling 25% ethanol petroleum ether to give the ketone as a pale yellow powder: m.p. 87-92°C (lit m.p. 96-97°C; Schneider, M.R. et al, J. Med. Chem. 25:1070 (1982)); Η NMR (CDC1 3 ) 58.03 (d, J=73 Hz, 2H), 7.62-7.45 (m, 3H), 7.20 (d, J=8.6 Hz, 2H), 6.89 (d, J=8.6 Hz, 2H), 4.25 (s, 2H), 3.8 (s, 3H). 2-(4-Methosyphenyl)-l-phenyl-l-ethanone-0-methyl oxime (10). o a solution of 2-(4-methoxyphenyl)- 1-phenyl-l-ethanone (5, 1.77 g, 7.82 mmol) in pyridine (30 ml, dried over molecular sieves) under nitrogen was added methoxylamine hydrochloride (784 mg, 9.39 mmol, Aldrich, used as is) at room temperature. The resulting pale yellow solution was stirred at room temperature overnight The pyridine was evaporated with mild heating. The residual sohds were stirred with ether (50 ml), and the resulting suspension was filtered. The filtrate was dried over potassium carbonate, and the solvent evaporated to give a clear, pale yellow syrup. This syrup was purified by column chromatography on 20 g neutral alumina (activity I) using 3% ethyl acetate/toluene as eluant The oxime was isolated as 1.664 g of a clear colorless syrup (83% yield). NMR analysis indicated that the syn- and anti-isomers were formed in a 3:1 ratio: R f 0.65, 0.55 (5% ethyl acetate/benzene); IR (CDC1 3 ) 2989 (w), 2947 (w), 2904 (w), 2838 (w), 2819 (w), 1614 (m), 1512 (s), 1245 (s), 1039 (w); Η NMR (CDα 3 ) 57.83 (m, IH), 737-7.23 (m, 4H), 7.15 (d, J=8.6 Hz, IH), 7.10 (d, J=8.6 Hz, IH), 6.80 (t, J=8.4 Hz, 2H), 4.10 (s, IH), 4.05 (s, 1.5H), 3.91 (s, IH), 3.78 (s, 3H). Low resolution mass spec. 255(M, 16), 224(26), 223(100), 209(19), 208(89), 121(100). l-Am_no-2-(4-methoxyphenyl)-l-phenylethane (15). To a solution of a mixture of syn- and anti- isomers of 2-(4-methoxyphenyl)-l-phenyl- 1-ethanone-O-methyl oxime (10, 1.65 g, 6.46 mmol) in THF (40 ml, freshly distilled from sodium benzophenone ketyl) under nitrogen was added borane-tetrahydrofuran solution (21.2 ml, 21.2 mmol, 1.0 M solution, Aldrich) at room temperature. The resulting pale yellow solution was refluxed overnight, and cooled in an ice water bath. Water (50 ml) was carefully added to quench, followed by 20% NaOH (50 ml). The resulting colorless bi-phasic mixture was refluxed with vigorous magnetic stirring overnight, and allowed to cool to room temperature. Hexanes (40 ml) were added, and the layers separated. The aqueous portion was extracted with hexanes (1x40 ml). The combined organic portions were dried over potassium carbonate, and concentrated in vacuo to afford a colorless, shghtly cloudy syrup. This syrup was purified by column chromatography on neutral alumina (I, 15 g) using an elution gradient of chloroform to 10% methanol/chloroform. The amine 15 was isolated as 1.263 g of a clear, colorless syrup (86% yield): R f 0.20 (5% methanol/chloroform); IR (CDC1 3 ) 3376 (w), 3316 (w), 3068 (w), 3031 (w), 3007 (w), 2965 (m), 2940 (m), 2910 (m), 2834 (m), 1614 (m), 1584 (m), 1514 (s), 1493 (m), 1466 (m), 1454 (m), 1441 (m), 1300 (m), 1245 (s), 1179 (m), 1106 (w), 1033 (m); Η NMR (CDC1 3 ) 57.40-7.24 (m, 5H), 7.11 (d, J=8.6 Hz, 2H), 6.85 (d, J=8.6 Hz, 2H), 4.18 (dd, J=8.6, 4.9 Hz, IH), 3.81 (s, 3H), 2.98 (dd, J=13.5, 4.9 Hz, IH), 2.79 (dd, J=13.5, 8.7), 1.49 (s, 2H). Low resolution mass spec. 228(M+1, 26), 211(49), 121(44), 107(69), 106(100), 79(100). l-(N--ethylr-(2,2r-ethc^))--aιιιmo^ (20). To a solution of the amine 15 (1.246 g, 5.482 mmol) in DMF (50 ml, dried over molecular sieves) under nitrogen at room temperature was added bromoacetaldehyde diethylacetal (2.70 g, 13.7 mmol, distilled) and potassium carbonate (3.03 g, 21.2 mmol). The resulting clear colorless suspension was immersed in an oil bath at 100°C. After 23 hours, the resulting yellow reaction mixture was allowed to cool to room temperature and mixed with 10% NaOH (100 ml). The resulting cloudy mixture was extracted with methylene chloride (3x40 ml). The combined extracts were washed with water (5x60 ml, Nad was used to break up emulsions in the later extractions) and brine (1x50 ml), and dried over potassium carbonate. Concentration in vacuo with mild heating ( 50°C) afforded a golden syrup, which was purified by flash chromatography on 30 g sihca gel using an elution gradient of hexanes to 12% ethyl acetate/hexanes. The acetal 20 was isolated as 1316 g of a clear, pale yellow syrup (70% yield): R f 0.39 (hexanes/ethyl acetate 2:1); IR (CDC1 3 ) 3340 (w), 3031 (w), 2983 (m), 2934 (w), 2910 (w), 2838 (w), 1614 (m), 1512 (s), 1467 (m), 1454 (m), 1444 (m), 1376 (w), 1303 (w), 1247 (s), 1177 (m), 1126 ( ), 1061 (m), 1035 (m); Η NMR (CDC1 3 ) 5736-7.23 (m, 5H), 7.06 (d, J=8.5 Hz, 2H), 6.82 (d, J=8.4 Hz, 2H), 4.52 (t, J=5.7 Hz, IH), 3.80 (s, 3H), 3.8 (m, IH, hidden under the singlet at 3.80), 3.56-3.50 (m, 2H), 3.49-3.42 (m, 2H), 2.98-2.89 (m, 2H), 2.55-2.47 (m, 2H), 1.68 (s, IH), 1.11 (dt, J=7.0, 4.2 Hz, 6H). pending. Low resolution mass. spec. 344(M+1, 33), 298(16), 222(63), 211(43), 176(100), 121(57), 91(90). (±) 3-Methσxy-IDDC (25). To the neat acetal 20 (219.2 mg, 0.6382 mmol) under nitrogen at room temperature was added perchloric acid (69% solution, 1.28 g, 12.8 mmol). The resulting dark yellow solution was stirred at room temperature. After 64 hours, the reaction mixture was a clear, pale brown gel. Cracked ice was added, followed by 10% NaOH (15 ml). A cloudy white mixture resulted, along with an amorphous yellow sohd. The whole was extracted with methylene chloride (3x8 ml); the yellow sohd did not dissolve. The combined organic extracts were washed with brine (1x10 ml) and dried over potassium carbonate. Concentration in vacuo afforded 136 mg of a pale brown foam. This foam was purified by flash chromatography on 4.0 g sihca gel using an elution gradient of ethyl acetate to 20% methanol/ethyl acetate (the methanol contained 1% concentrated ammonium hydroxide). The desired product 25 was isolated as 18.2 mg of a clear, colorless syrup (11% yield): R f 0.17 (ethyl acetate methanol 4:1); X H NMR (CDC1 3 ) 57.2 (br s, 4H), 6.97 (d, J=8.4 Hz, IH), 6.75 (d, J=2.4 Hz), 6.70 (d, J=2.5 Hz), 6.67 (d, J=2.6 Hz, 2H over 6.75-6.67), 4.33 (t, J=3.6 Hz, IH), 3.86 (d, J=4.2 Hz, IH), 3.79 (s, 3H), 3.66 (d, J=11.8 Hz, IH), 3.43 (dd, J=17.2, 3.7 Hz, IH), 3.32 (dd, J=11.5, 4.7 Hz, IH), 3.16 (dd, J=17.2, 3.3 Hz, IH), 2.12 (s, IH). 13 C NMR (CDC1 3 ): 157.8, 144.1, 1413, 140.4, 132.4, 127.2, 127.1, 126.8, 125.5, 124.9, 113.6, 112.2, 55.3, 55.2, 50.7, 47.3, 41.0; low resolution mass spec. 251(M, 31), 250(23), 222(66), 179(34), 178(31), 130(100). G. Synthesis of (±) 3-CMoro-7-methoxy-IDDC 2-(4-Chlorophenyl)-l-(4-methoxyphenyl)- 1-ethanone. 4- Chlorophenylacetyl chloride was prepared as described before. To a suspension of aluminum chloride (1.27 g, 9.52 mmol) and anisole (1.4 g, 12.9 mmol) in CH 2 C1 2 (40 ml) under nitrogen was added 4- chlorophenylacetyl chloride (1.8 g, 9.52 mmol) over a period of 30 minutes as a solution in CH 2 C1 2 at room temperature. The resulting clear, pale yellow solution was refluxed for 18 hours. After cooling to room temperature, the resulting solution was poured into 100 ml ice water. The layers were separated and the aqueous portion was extracted with methylene chloride (50 ml, 2 times). The combined organic layers were washed with water (50 ml, 2 times), 10% NaOH (30 ml, 2 times), water (30 ml, 2 times), and brine (40 ml). The organic solution was further dried over MgS0 4 , filtered, and concentrated to yield a white sohd (2.45 g, 99% yield). 1^: 0.41 (CH 2 C1_). 2-(4 Moκφhe * ^l)-l-(4-methocsyphe * _^)-l- ethancme-O-methyl oxime. To a solution of 2-(4-chIorophenyl)-l-(4- methoxyphenyl)-l-ethanone (1.386 g, 5.3 mmol) in 10 ml pyridine under nitrogen was added methoxylamine hydrochloride (0.664 g, 7.96 mmol) at 25°C. The resulting mixture was stirred at 20°C for 17 hours. The pyridine was removed in vacuo with heating. The residual sohds were a mixture of the oxime geometrical isomers as a white syrup (1.41 g, 92% yield). R f -. 0.45, 0.64 (CH 2 C1 2 ). l-Amino-2-^4-chlorophenyl)~l-(4-methccyphenyl)ethane. To a solution of 2-(4-chlorophenyl)-l-(4-metho?yphenyl)-l-ethanone-0-methyl oxime (134 g, 4.62 mmol) in 30 ml diy THF under nitrogen was added borane-THF complex (1.0 M in THF, 23.1 ml, 23.1 mmol) by syringe at 25°C. The resulting bi-phasic solution was refluxed with vigorous magnetic stirring for 16 hours. After the reaction was cooled to 25°C, quenched with 10% NaOH solution, hexanes (50 ml) were added and the layers were separated. The aqueous portion was extracted with hexanes again (40 ml). The combined organic layers were dried over magnesium sulfate and concentrated in vacuo to yield a cloudy colorless syrup (1.18 g, 98% yield). R * : 0.32 (CH 2 Cl 2 /MeOH 20:1). l-(N-Ethyl-(2,2-etho__y))-amino-l-(4-methoxyρhenyl)-2-(4- chlorophenyl)-ethane. To a stirred mixture of l-amino-2-(4- chlorophenyl)-l-(4-methoxyphenyl)ethane (340 mg, 1.3 mmol) and anhydrous potassium carbonate (193.5 mg, 1.4 mmol) in 2.5 ml of N,N- dimethylformamide was added dropwise a solution of bromoacetaldehyde diethylacetal (276 mg, 1.4 mmol) at 90°C. The resulting mixture was heated with stirring. After 18 hours the reaction mixture was cooled to 10°C, 50 ml of IN NaOH was added followed by 25 ml of CH 2 C1 2 . The layers were separated and the aqueous layer was extracted with CH 2 C1 2 (15 ml, two times). The combined organic layers were washed with NaOH (IN, 10 ml) and water (50 ml, 10 times), dried (K 2 C0 3 ), and concentrated to yield the crude product The crude product (450 mg) was chromatographed (20 g sihca gel) using CH 2 C1 2 followed by CH j Q THF (20:1) then OE^CyiΗF (5:1) as eluent The pure product was obtained as a white sohd (386 mg, 89% yield). R f : 0.58 (CH THF 1:5). X H NMR (CDC1 3 ): 57.22 (m, 2H, phenyl), 7.05 (d, IH, J=8.4 Hz, phenyl), 6.87 (d, IH, J=8.6 Hz, phenyl), 4.53 (t, IH, J=5.5 Hz, IH), 3.83 (s, 3H, CH 3 ), 3.60 (m, 2H, CH 2 ), 3.44 (m, 2H, CH 2 ), 2.77 (t, IH, J=7.0 Hz, CH), 2.90 (d, 2H, J=7.0 Hz, CH 2 ), 2.54 (m, 2H, CH 2 ), 1.65 (br., IH, NH), 1.15 (t, 6H, J=7.0 Hz, CH 3 ). 13 C NMR (CDC1 3 ): 137.56, 135.41, 132.19, 130.74, 128.42, 128.37, 113.92, 102.07, 64.10, 62.07, 62.12, 55.33, 49.97, 44.70, 15.35. 3-Chloro-7-methoxy-IDDC. l-(N-Ethyl-(2,2-ethoxy))-amino-l-(4- methoxyphenyl)-2-(4-chlorophenyl)ethane (180 mg, 0.54 mmol) and perchloric add (5 ml of 70% solution) were mixed together at room temperature under nifrogen. The resulting white mixture was stirred at room temperature for 60 hours, followed by quench and basification with ice and 10% NaOH. The resulting cloudy mixture was extracted with methylene chloride (25 ml, 3 times), and the combined extracts were washed with brine (10 ml) and dried over sodium sulfate. Concentration in vacuo afforded an amber syrup, which was purified by prep, thin layer chromatography (sihca gel) using CHC MeOH (9:1) as an eluent 3- Chloro-7-methoxy-IDDC was isolated as a clear yellow syrup (100 mg, 77% yield). R-: 0.36 (CHCl^eOH 9:1). Η NMR (CDCL,): 5730-6.79 (m, 6H), 4.44 (t, J=3.5 Hz, IH), 3.86 (d, IH), 3.85 (s, 3H, CH 3 ), 3.69 (dd, J * =12.2 Hz, IH), 3-56 (dd, J=17.0, 3.3 Hz, IH), 3.37 (dd, J=13.7, 4.4 Hz, IH), 3.18 (dd, J=18.5, 4.5 Hz, IH). M C NMR (CDC1 3 ): 159.8, 143.1, 141.2, 132.9, 132.7, 131.5, 128.6, 127.9, 127.3, 127.0, 112.8, 111.7, 55.4, 54.0, 48.8, 45.8, 39.5. High resolution mass spec: C^H^NOϋ 285.0920 (caL), 285.0910 (exp.). H. Synthesis of (±) 3-Ehιoro-IDDC 2-(4-FIuorophenyι)-l- heny_-l-ethanone. a) 4-Fluorophenylacetyl chloride: A mixture of 4- fluorophenylacetic add (8 g, 52 mmol) and phosphorous trichloride (7.13 g, 52 mmol) in a round bottom flask under nitrogen was heated to 95 °C for 1 hour. A mixture of colorless hquid and yellow amorphous sohd was formed. The liquid was decanted and used directly for the next step. b) 2-(4-Fluorophenyl)-l-phenyl-l-ethanone: To a suspension of aluminum chloride (6.927 g, 52 mmol) and in dry benzene (60 ml) under nifrogen was added crude 4-fluorophenylacetyl chloride (approximately 52 mmol) over a period of 30 minutes at room temperature. The resulting clear, pale yellow solution was refluxed for 18 hours. After cooling to room temperature, the resulting solution was poured into 100 ml ice water. The layers were separated and the aqueous portion was extracted with methylene chloride (100 ml, 2 times). The combined organic layers were washed with water (100 ml, 2 times), 10% NaOH (50 ml, 2 times), water (100 ml, 2 times), and brine (40 ml). The organic solution was further dried over MgS0 4 , filtered, and concenfrated to yield the crude product as a white sohd (10 g, 98% for two steps). R f : 0.63 (CH 2 C1 2 ). IR (CH 2 C1 2 ) 1700 cm "1 (C=0). 2-(4-Fluorophenyl)-l-phenyl-l-ethanone-0-methyl oxime. To a solution of 2-(4-fluorophenyl)-l-phenyl-l-ethanone (5 g, 30 mmol) in 30 ml pyridine under nitrogen was added methoxylamine hydrochloride (3.8 g, 45 mmol) at 25 °C. The resulting mixture was stirred at 25 °C for 17 hours. The pyridine was removed in vacuo with heating. The residual sohds were a mixture of the oxime geometrical isomers as a white syrup and it was used for the next step without further purification. R f : 0.48, 0.70 (CH 2 C1 2 ). l-Amino-2-(4-f_uorophenyl)-l-phenylethane. To a solution of 2-(4- fluorophenyl)-l-phenyl-l-ethanone-0-methyl oxime (1.34 g, 4.62 mmol) in 30 ml dry THF under nitrogen was added borane-THF complex (1.0 M in THF, 23.1 ml, 23.1 mmol) and diy pyridine (10 ml) by syringe at 25°C. The resulting bi-phasic solution was refluxed with vigorous magnetic stirring for 16 hours. After the reaction was cooled to 25 °C and was quenched with 10% NaOH solution, hexanes (50 ml) were added and the layers were separated. The aqueous portion was extracted with hexanes again (40 ml). The combined organic layers were dried over magnesium sulfate and concentrated in vacuo to yield a cloudy colorless syrup (3.55 g, 66% yield for two steps). R f : 0.24 (EtOAc). l-(N-Et 2^-et c^))-aI___no-2-(4-__uo^o henyl)-l-p enylethane. To a stirred mixture at 90 °C of l-amino-2-(4-fluorophenyl)-l- phenylethane (2.15 g, 10 mmol) and anhydrous potassium carbonate (1.52 g, 11 mmol) in 5 ml of N,N-dimethylformamide were added dropwise a solution of bromoacetaldehyde diethylacetal (2.17 g, 11 mmol). The resulting mixture was heated with stirring. After 18 hours the reaction mixture was cooled to 10 °C, 50 ml of IN NaOH was added followed by 50 ml of CH 2 C1 2 . The layers were separated and the aqueous layer was extracted with CH 2 C1 2 (25 ml, two times). The combined organic layers were washed with NaOH (IN, 20 ml) and water (125 ml, 10 times), dried (K 2 C0 3 ), and concentrated to yield the crude product (2.9 g, 88% yield). R f : 0.53 (CH 2 α_ IHF 1:15). 3-Fluoro-IDDC. l-(N-Ethyl-(2,2-ethoxy))-amino-2-(4- fluorophenyl)-l-phenylethane (100 mg, 1.51 mmol) and perchloric add (12 ml of 70% solution) were mixed together at room temperature under nitrogen. The resulting white mixture was stirred at room temperature for 48 hours, followed by quench and basification with ice and 10% NaOH. The resulting cloudy mixture was extracted with methylene chloride (25 ml, 3 times), and the combined extracts were washed with brine (10 ml) and dried over sodium sulfate. Concentration in vacuo afforded an amber syrup, which was purified by prep, thin layer chromatography (sihca gel) using CHCVNleOH (9:1) as an e ient 3-Fluoro-IDDC was isolated as a yellow syrup (175 mg, 49% yield). R,: 037 (CHC MeOH 9:1). Η NMR (CDC1 3 ): 57.21-6.77 (m, 7H), 435 (t, J = 3.7 Hz, IH), 3.84 (d, J = 4.2 Hz, IH), 3.63 (d, J = 11.6 Hz, IH), 3.48 (dd, J = 17.4, 3.3 Hz, IH), 3.25 (dd, J = 11.6, 4.8 Hz, IH), 3.16 (dd, J = 17.4, 2.6 Hz, IH). C NMR (CDC1 3 ): 142.5 (d, J &F = 263.8 Hz), 139.6, 132.9, 132.8, 130.5, 127.5, 127.2, 125.6, 125.1, 114.5 (d, J^ = 21.0 Hz), 113.6 (d, J^ F = 20.8 Hz), 54.9, 50.3, 46.6, 40.7. High resolution mass, spec: ^NF 239.1110 (cal.), 239.1132 (exp.). I. Synthesis of (±) 3-Bramo-7-me_hoxy-IDDC 4-Bromophenylacetyl chloride. A mixture of 4-bromophenylacetic add (6.45 g, 30 mmol) and phosphorous trichloride (4.12 g, 30 mmol) in a round bottom flask under nitrogen was heated to 50 °C, for 30 min, and at 100 °C for 3 hr and then it was allowed to cool to room temperature. A light yellow precipitate appeared after 30 minutes, and the predpitate had congealed into an amorphous yellow sohd. The remaining liquid was decanted. The sohd was rinsed with methylene chloride (2x5 ml), and the rinses were combined with the decanted liquid. Concentration via rotary evaporation afforded a syrupy pale yellow residue, which was purified by vacuum distillation (short path). The add chloride was isolated as a clear colorless liquid, (1.804 g 26% yield): b.p. 85-88°C 0.8 torr. 2-(4-Bromophenyl)-l-(4-metho_cjphenyl)-l-ethanone. To a suspension of aluminum chloride (.97 g, 7.28 .mmol) in 40 ml AR dichloromethane under nitrogen was added at room temperature 4- bromophenylacetyl chloride (1.70 g, 7.28 mmol) over a period of 20 minutes as a solution in 15 ml dichloromethane. The resulting clear, off- red solution was refluxed for six hours. After cooling to room temperature, the resulting grey-brown solution was poured into 10 ml ice water. The layers were separated and the aqueous portion extracted with dichloromethane (1x20 ml). The combined organic portions were washed with water (1x30 ml), 10% NaOH (1x30 ml), water (1x30 ml), and brine (1x30 ml), and dried over sodium sulfate. Filtration followed by concentration in vacuo, afforded the ketone as a white crystalline sohd (2.14 g, 96% crude yield). This product was used in the next step without any further purification. 2-(4-Bromophenyl)-l-(4-metho * _yphenyl)-l-ethanone-0-methyl oxime. To a solution of 2-(4-bromophenyl)-l-(4-methoxyphenyl-l- ethanone 1.987 g, 6.51 mmol) in 20 ml pyridine (anhydrous) under nitrogen was added at room temperature methoxylamine hydrochloride (820 mg, 9.77 mmol). The resulting shghtly cloudy, pale orange mixture was stirred at room temperature for 15 hr. The pyridine was removed in vacuo with heating. The residual sohds were stirred with ether (60 ml), isolated by filtration, and discarded. The filtrate was dried over sodium sulfate, and concentrated in vacuo to a mixture of the oxime geometrical isomers as a clear, pale yellow syrup, (2.145 g, 98.5% crude yield). This product was used in next step without any further purification. 2-(4-Bromophenyl)-l-(4-metho_yphenyl)-l-a-n_no ethane. To a solution of oxime geometric isomers (2.01 g, 6.01 mmol) in 50 ml anhydrous THF under nifrogen was added borane-tetrahydrofuran complex (1.0 M in THF, 30.1 ml, 30.1 mmol) by syringe at room temperature. The resulting pale yellow solution was refluxed 3 hrs, and cooled in an ice bath. Water (25 ml) was carefully added to quench, followed by 20% NaOH (40 ml), the resulting bi-phasic solution was refluxed with vigorous magnetic stirring for 18 hrs. After cooling to room temperature, hexanes (40 ml) were added, and the layers were separated. The aqueous portion was extracted with hexanes (1x40 ml). The combined organic portions were dried over potassium carbonate and concentrated in vacuo to an off-white syrup, (1.913 g, 98.8% crude yield). This product was used in next step without any further purification. l-(N-ethyI-(2,2-ethθ3qr))-amino-l-(4-metho_cyρhenyl)-2-(4- bromophenyl) ethane. To a solution of the amine (1.82 g, 5.65 mmol) in 17 ml anhydrous DMF was added potassium carbonate (859 mg, 6.21 mmol) and bromoacetaldehyde diethylacetal (1.22 g, 6.21 mmol, Aldrich, used as is) at room temperature under nitrogen. The resulting clear colorless suspension was heated at 100°C for 32 hours. After cooling to room temperature, the reaction mixture was mixed with 10% NaOH (100 ml). The resulting yellow cloudy mixture was extracted with methylene chloride (3x50 ml). The combined organic portions were washed with IN NaOH solution (1x30 ml), water (1x30 ml) and brine (1x30 ml), dried over potassium carbonate. Concentration in vacuo afforded a light orange hquid that was purified by flash chromatography on sihca gel, using 8:2 hexanes/ethyl acetate as eluant The acetal was isolated as a colorless syrup, which solidified in refrigerator to give an off-white sohd, (2.1 g, 87.8% yield). (±) _S-Brσmo-7-methoxy-IDDC. The acetal (1.032 g, 2.44 mmol) and perchloric add (20 g of a 69% solution) were mixed together at room temperature under nitrogen. The resulting light-brown mixture was stirred at room temperature for 52 hours, followed by quench and basification with ice and 10% NaOH (100 ml). The resulting cloudy mixture was exfracted with methylene chloride (3x50 ml), and the combined extracts were washed with 2N aq. NaOH solution (1x50 ml), water (1x50 ml), brine (1x50 ml) and dried over potassium carbonate. Concentration in vacuo afforded an amber syrup, which was purified by flash chromatography on sihca gel using 10:1 chloroformymethanol as eluent The 3-bromo-7-methoxy-_DDC was isolated as a shiny white sohd, (0.516 g, 64% yield). Η NMR (CDC1 3 ): 5734-6.73 (m, 6H), 433(t, J = 3.4 Hz, IH), 3.79 (d, IH), 3.79 (s, 3H, CH 3 ), 3.61 (d, J = 11.7 Hz, IH), 3.43 (dd, J = 17.7, 3.6 Hz, IH), 3.28 (dd, J * = 11.5, 4.6 Hz, IH), 3.11 (dd, J = 17.7, 3.2 Hz, IH). 13 C NMR (CDC1 3 ): 159.1, 144.7, 141.9, 134.4, 133.2, 131.9, 130.7, 129.8, 126.2, 119.4, 112.3, 111.6, 55.4, 54.0, 50.1, 46.8, 41.4. High resolution mass, spec: C 17 H 16 NBrO 329.0415 (cal.), 329.0428 (exp.). J. Synthesis of (±) N-Me l-3-bromo-7-methα_y-__DDC To a solution of 3-bromo-7-methoxy-_DDC (50 mg, 0.15 mmol) in 1.1 ml of formic add under nitrogen was added formaldehyde (37% aqueous solution, 0.061 ml, 0.758 mmol) at room temperature. The reaction mixture was stirred at room temperature for three hours and further refluxed for two hours. The resulting solution was basified with aqueous NaOH (IN) to pH 12 and extracted with methylene chloride (40 ml, two times). The organic extracts were combined, dried (MgS0 4 ), filtered, and concentrated to yield the crude product The crude product was purified by prep, thin layer chromatography (sihca gel) using CHC MeOH (9:1) as an eluent N-Methyl-3-bromo-7-methoxy-IDDC was isolated as a yellow syrup (42 mg, 78% yield). X H MNR (CDC1 3 ): 5731-6.75 (m, 6H), 3.93-3.74 (m, 2H), 3.79 (s, 3H, CH 3 ), 3.60-3.53 (m, 2H), 2.94-2.85 (m, 2H), 2.49 (s, 3H, CH 3 ). 13 C NMR (CDC1 3 ): 159.2, 144.2, 141.9, 134.4, 133.0, 130.5, 130.3, 129.8, 127.1, 119.2, 112.2, 111.2, 61.8, 59.3, 55.4, 46.9, 45.3, 38.6. High resolution mass spec: C 18 H 18 BrNO 343.0571 (cal.), 343.0564 (exp.). K- Synthesis of (±) 3-Iodo-IDDC The method of Thompson et al was followed (Thompson, W.T. et al J. Med Chem. 55:789-808 (1990); see also Takagi, ; Hayama, N.; Okamoto, T. Chem. Lett. p. 191 (1978)). A mixture of 3-bromo-IDDC (75 mg, 0,25 mmol), nickel powder (73 mg. 1.3 mmol, Aldrich, 3 micron particle size), potassium iodide (83 mg, 0.50 mmol), iodine (3 mg, 0.01 mmol) and DMF (0.50 ml, dried over molecular sieves) was degassed by bubbling nitrogen through for 20 minutes. A septum was placed on the flask with a nitrogen inlet, and the flask was immersed in an oil bath at 150 °C. After 5 hours of stirring, the heat was removed and the reaction mixture allowed to achieve room temperature. Water (5 ml) and ethyl acetate (5 ml) were added with stirring. The hquid portion was removed by pipette, and the residual sohds rinsed with ethyl acetate (3x5 ml). All the liquids were combined and hexanes (10 ml) were added. The layers were separated and the organic portion was dried over sodium sulfate. The solvent was evaporated to afford a clear brown syrup, which was purified by flash chromatography using an elution gradient of 100% ethyl acetate to 10% methanol (containing 1% concenfrated ammonium hydroxide) in ethyl acetate. A pale yellow, cloudy syrup was obtained (46.6 mg); proton NMR analysis indicated that this syrup was a mixture of 85% product (3-iodo-IDDC) and 15% starting material (3-bromo- IDDC). This mixture was subjected to the same reaction conditions with fresh reagents to yield material of the same product/starting material ratio (46% yield after the first reaction): f 0.23 (20% methanol/ethyl acetate); Η NMR (acetone-d 6 ) 57.62 (d, J=1.5 Hz, IH), 7.40 (dd, J=8.2, 1.6 Hz, IH), 7.29-7.10 (m, 4H), 6.81 (d, J=8.1 Hz, IH), 435 (t, J=3.5 Hz, IH), 3.97 (d, J=3.7 Hz, IH), 3.51 (dd, J=10.7, 0.9 Hz, IH), 3.36 (dd, 1=17.7, 3.6 Hz, IH), 3.23 (dd, J=113, 4.7 Hz, IH), 3.03 (dd, J=17.7, 3.2 Hz, IH); 1.26 (s, IH). L. Synthesis of (-)-3-Chloro-IDDC To a solution of (±)-3-chloro-IDDC (484.3 mg, 1.894 mmol) in 1.40 ml methyl ethyl ketone at 50°C was added a warm solution of (+)-di- _-»-toluoyl-D-tartaric add monohydrate (772 mg, 1.91 mmol) with stirring. A white precipitate formed immediately. The reaction flask was fitted with a condenser and the reaction mixture stirred under nitrogen at 50°C for 48 hours. The precipitated salt was collected on a Hirsch funnel and rinsed with cold acetone. The precipitate (1.0368 g of a pale brown powder; m.p. 174-176 dec; [o*] D 25 =70°C, c=l, MeOH) was subjected to recrystalhzation conditions using boiling methyl ethyl ketone, methanol (20:1); however, sohd formation was not realized. The solvent was evaporated, and the salt was partitioned between methylene chloride (20 ml) and 4 M NH 4 OH (20 ml). The layers were separated and the aqueous portion extracted with methylene chloride (2x15 ml). The combined organic portions were dried over potassium carbonate and concenfrated in vacuo to yield the free base (ie., 3-chloro-IDDC) as a clear brown syrup. This cycle was completed twice more, each time using 1.02 equivalents of the tartaric add relative to the free base, stirring in methyl ethyl ketone or 48 hours at 50 °C followed by regeneration of the free base, to yield (-)-3-chloro-IDDC as 94 mg of a clear, colorless syrup (unoptimized). R f 0.17 (ethyl acetate/methanol 4:1); [c-] D 25 =-144° (c=l, EtOH); Η NMR (CDC1 3 ) 57.26-7.18 (m, 5H), 7.08 (dd, J=8.1, 2.1 Hz, IH), 6.97 (d, J=8.2 Hz, IH), 4.32 (t, J=3.7 Hz, IH), 3.87 (d, J=4.5 Hz, IH), 3.65 (d, J=11.7 Hz, IH), 3.45 (dd, J=17.6, 3.8 Hz, IH), 3.32 (dd, J=11.5, 4.8 Hz, IH), 3.17 (dd, J=17.6, 3.4 Hz, IH), 1.99 (s, IH). Example 10: PCP Binding Data for IDDC Analogs The PCP receptor affinities of the IDDC analogs against [ 3 H]MK- 801 synthesized above were determined as described by Keana F.W. et al, Proc. Nail Acad Sci. (USA) &5.5631-5635 (1989). The results appear in Table 2. As can be seen in Table 2, the IDDC analogs of the invention exhibit high binding to the PCP receptor. BflMDING DATA FOR IDDC ANALOGS Having now fully described this invention, it will be understood to those of ordinary skill in the art that the same can be performed within a wide and equivalent range of conditions, formulations and other parameters without affecting the scope of the invention or any embodiment thereof.

Claims: WHAT IS CLAIMED IS: 1. A compound having the foπnula: wherein: R is hydrogen, - acyl, -Cg alkyl, aryl, C x -C 6 alkoxycarbonyl, -Cy, aralkyl, -Cg alkenyl, -C^ diallylaminoalkyl, C C 6 hydroxyalkyl, C_-C 6 alkynyl, - ,, alkykycloalkyl, or -Cg cycloalkyl; R 1 is hydrogen, -Cg alkyl, - alkenyl, C C 10 aralkyl, C r C 6 alkoxy, -C^ dialkylamino or C^-C^ dialkylaminoalkyl; X and Y are independently selected from the group consisting of a halogen such as chloro, fluoro, bromo, iodo, trifluoromethyl, azido, C r C 6 alkoxy, - dialkoxymethyl, -Cg alkyl, cyano, -C 15 dialkylaminoalkyl, carboxy, carboxamido, -Cg haloalkyl, C x -C 6 haloalkylthio, allyl, aralkyl, cycloaliyl, aroyl, aralkoxy, -Cg acyl, aryl, substituted aiyl, heteroaryl, substituted heteroaryl, -Cg heterocycloalkyl, -Cg alkylthio, Q-Cg alkylsulfonyl, -Cg haloalkyl- sulfonyl, - alkylsulfinyl, -Cg haloalkylsulfinyl, arylthio, -Cg halo- alkoxy, amino, -Cg alkylamino, -C^ dialkylamino, hydrojy, carbamoyl, C r C 6 N-alkylcarbamoyl, - 5 N,N-dialkylcarbamoyl, nifro and -C^ dialkylsulfamoyl; Z represents a group selected from wherein R 2 is hydrogen, -Cg alkyl, Q-Cg alkenyl, aralkyl, C 4 -C 15 dialkylaminoalkyl, heterocycloalkyl, C-rC 6 acyl, aroyl, or aralkanoyl, and R 3 is -Cg alkyl, Q-Cg alkenyl, phenyl, aralkyl or C 3 - 5 dialkylaminoalkyl; and n is an integer selected from 0 (X or Y is hydrogen, respectively), 1, 2, 3, or 4, with the proviso that at least one of n is other than 0; or a pharmaceuticaπy acceptable salt thereof and/or the opticaUy active form thereof and/or the radiolabeled form thereof; wherein said compound exhibits a high binding activity with respect to the PCP receptor in mammalian nerve cells. 2. 3-Chloro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 3. (+)3-Chloro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 4. 7-Methoxy-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 5. 3-Bromo-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 6. 3-Chloro-7-methoxy-5-(iminomethano)-10,ll-dihydro- H-dibenzo[a,d]cycloheptene, a compound of claim 1. 7. 3-Bromo-7-methoxy-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo[a,d]cycloheptene, a compound of claim 1. 8. 7-Chloro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cy oheptene, a compound of claim 1. 9. 3-Bromo-7-amino-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo[a,d]cycloheptene, a compound of claim 1. 10. 3-Bromo-7-methoxy-N-methyl-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo[a,d]cycloheptene, a compound of claim 1. 11. 3-FIuoro-5-(iminomethano)-10, ll-dihydro-5H-dibenzo- [a,d]cy oheptene, a compound of claim 1. 12. (+)3-Fluoro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 13. 3-Methoxy-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 14. 3-Iodo-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 15. (-)-3-Ghloro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, a compound of claim 1. 16. (±)-N-methyl-3-fluoro-5-(iminomethano)-10,ll-dihydro-5H- dibenzo[a,d]cycloheptene, a compound of claim 1. 17. (+^J-methyl-3-fluoro-5-(iminomethano)-10,ll-dihydro-5H- dibenzo[a,d]cycloheptene, a compound of claim 1. 18. (±)-N-methyl-3-chloro-5-(iminomethano)-10,ll-dihydro-5H- dibenzo[a,d]cycloheptene, a compound of claim 1. 19. (+)-N-methyl-3-chloro-5-(iminomethano)-10,ll-dihydro-5H- dibenzo[a,d]cycloheptene, a compound of claim 1. 20. A compound selected from the group consisting of 3-nitro-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-azido-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3- trifluoromethyl-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, N-methyl-3-trifluoromethyl-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3,7-difluoro-5- (iπ__ncHmethano)-10,ll-dihydro-5H-dibeι_zo-[a,d]cycloheptene, 3-phenyl-5- (hninomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-amino-5- (in-Jhomethano^lOjll-ά^ydrcj-SH-dibenzo-fajdJcycloheptene, 8-hydro * _y-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-hydrojy-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 8-metho_y- 5-(inιinomethano)-10,ll-dihydrcH5H-dibeι_zo-[a,d]cycloheptene, 3-cyano-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3- methylthio-5-(iminomethano)- 10,11 -dihydro-5H-dibenzo-[a,d]cycloheptene (+)-5-(iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cycloheptene, N- me yl-5-(inmiomethano)-10,ll-dihydro-5H-dibenzo[a,d]-cycloheptene and N-methyl-3-iodo-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene; or a pharmaceutically acceptable salt thereof and/or the opticaUy active isomer thereof and/or the radiolabeled form thereof. 21. The compound of claim 1 or 20, wherein said radiolabel is 3 H, U C, 1 C, 18 F, N, I, I, 35 S or 32 P. 22. A method of treating or preventing neuronal loss, comprising administering to an animal in need of such treatment an effective amount of a compound having the formula wherein: R is hydrogen, -Cg acyl, -Cg alkyl, aryl, -Cg alkoxycarbonyl, Cy-C y , aralkyl, C-.-C 6 alkenyl, C j -C^ diallylaminoalkyl, -Cg hydroxyalkyl, -Cg alkynyl, Q-C^ trialkylsifyl, - ,, alkylcycloalkyl, or Q-C 6 cycloalkyl; R 1 is hydrogen, -Cg alkyl, -Cg alkenyl, C o aralkyl, C r C 6 alkoxy, - j dialkylamino or C 3 - 5 diallcylaminoalkyl; X and Y are independently selected from the group consisting of a halogen such as chloro, fluoro, bromo, iodo, trifluoromethyl, azido, C C 6 alkoxy, -Cg dialkoxymethyl, -Cg alkyl, cyano, C 3 -C I5 diallcylamino¬ alkyl, carboxy, carbσxamido, -Cg haloalkyl, C r C 6 haloalkylthio, aUyl, araliyl, -Cg cycloalkyl, aroyl, aralkoxy, -Cg acyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C j -Cg heterocycloalkyl, C r C 6 alkylthio, -Cg alkylsulfonyl, -Cg haloalkylsulfonyl, C r C 6 alkylsulfinyl, -Cg haloalkylsulfinyl, aiylthio, -Cg haloalkoxy, amino, -Cg alkylamino, - C j5 dialkylamino, hydroxy, carbamoyl, C x -Cg N-alkylcarbamoyl, C^-C^ N,N- dialkylcarbamoyl, nitro and -Cu dialkylsulfamoyl; Z represents a group selected from H R 3 R 3 H \ \ / \ / \ / \ / C=0 C . C , C . or C ; / / \ / \ / \ / \ , H H OH OR 2 wherein R 2 is hydrogen, C r Cg alkyl, -Cg alkenyl, aralkyl, C 4 -Cι 5 dialkylaminoalkyl, heterocycloalkyl, -Cg acyl, aroyl, or aralkanoyl, and R 3 is -Cg alkyl, -Cg alkenyl, phenyl, aralkyl or - s dialkylaminoalkyl; and n is an integer selected from 0 (X or Y is hydrogen, respectively), 1, 2, 3, or 4, with the proviso that at least one of n is other than 0; or a pharmaceutically acceptable salt thereof and/or the opticaUy active isomer thereof; wherein said compound exhibits a high binding activity with respect to the PCP receptor in mammalian nerve cells. 23. The method of claim 22, wherein said compound is selected from the group consisting of 3-Chloro-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo-[a,d]cycloheptene, (+) 3-Chloro-5-(iminomethano)-10,ll- dihydro-5H-dibenzo-[a,d]cycloheptene, 7-Methoxy-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-Bromo-5-(iminomethano)- 10, 1 l-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-Chloro-7-methoxy-5- (iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]cycloheptene, 3-Bromo-7- methoxy-5-(iminomethano)-10, 11 -dihydro-5H-d_benzo[a,d]cycloheptene, 7-Chloro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-Bromo-7-amino-5-(iminomethano)-10,ll-dihydro-5H-dibenzo[a,d] cycloheptene, 3-Bromo-7-methoxy-N-methyl-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-F_uoro-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, (+) 3-Fluoro-5-(imino- methano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-Methoxy-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3-Iodo-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, (-)-3- Chloro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene,3- nitro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3- azido-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, 3- trifluoromethyl-5-(iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cyclo- heptene, 3,7-difluoro-5-(iminomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene -phenyl-5-(iminomethano)-10, 1 l-dihydro-5H-dibenzo- [a,d]cycloheptene,3-amino-5-(_minomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, 8-hydro * ty-5-( * ___inomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, 3-hydrojy-5-(_minomethano)-10,ll-dihydro-5H-dibenzo- [a,d]cycloheptene, 8-methoxy-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo-[a,d]cycIoheptene, 3-cyano-5-(iminomethano)-10,ll-dihydro- 5H-dibenzo-[a,d]cycloheptene, 3-methylthio-5-(iminomethano)- 10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene (±)-N-methyl-3-fluoro-5- (iminomethano)-10,ll-dihydro-5H-dibenzo-[a,d]cycloheptene, (+)-N- methyl-3 -fIu oro-5-(iminomethano) - 10 , l l- dihydro-5H- dibenzo[a,d]cycloheρtene, (±)-N-me yl-3-cUorcH5-(iminomethano)- 10,11- dihydro-5H-dibenzo[a,d]cycloheptene, and (+)-N-methyl-3-chloro-5- (iminomethano)-10,ll-dihydro-5H-dibenzo[a,d]-cycloheptene. 24. The method of claim 22, wherein said neuronal loss is associated with ischemia, hypoxia, hypoglycemia, brain or spinal chord trauma, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease or Down's Syndrome. 25. The method of claim 22, wherein said animal is a human suffering from ischemic brain insult and said compound is administered as part of a pharmaceutical composition comprising a phaπnaceuticaUy acceptable carrier. 26. The method of claim 22, wherein said compound is administered as part of a pharmaceutical composition comprising a pharmaceuticaUy acceptable carrier.

Inventors: BARMETTLER PETER, KEANA JOHN F W, WEBER ECKARD, BARMETTLER, PETER, KEANA, JOHN, F., W., WEBER, ECKARD
Applicants: OREGON STATE, STATE OF OREGON, ACTING BY AND THROUGH THE OREGON
Application year: 1992
Main classification: A61K31
IPC codes: A61K31, A61K51, A61P3, A61P9, A61P25, C07D471