N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders

Abstract: A class of N-arylheteroarylalkyl imidazol-2-one compounds is described for use in treatment of circulatory disorders such as hypertension and congestive heart failure. Compounds of particular interest are angiotensin II antagonists of the formula wherein A is selected from wherein m is one; wherein R¹ is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, 2-ethylbutyl, n-pentyl, neopentyl, phenyl, methylphenyl, difluorophenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, cyclohexanoyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R⁰ is hydrido; wherein R² is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, propylthio, butylthio, and hydroxyalkyl; wherein each of R³, R⁴, R⁶, R⁷, R⁸, R⁹, R¹⁰ and R¹¹ is hydrido and R⁵ must be selected from COOH, SH, PO₃H₂, SO₃H, CONHNH₂, CONHNHSO₂CF₃, OH, wherein each of R⁴² and R⁴³ is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl; or a tautomer thereof or a pharmaceutically-aceptable salt thereof.

Description: Related Application This a continuation-in-part of U.S. Application Ser. No. 07/681,011 filed 5 April 1991. Field of the Invention Non-peptidic N-arylheteroarylalkyl imidazol-2-one compounds are described for use in treatment of circulatory disorders such as hypertension and congestive heart failure. Of particular interest are angiotensin II antagonist compounds provided by an imidazol-2-one having a arylheteroarylmethyl moiety attached to a nitrogen atom of the imidazol-2-one. Background of the Invention The renin-angiotensin system is one of the hormonal mechanisms involved in regulation of pressure/volume homeostasis and in expression of hypertension. Activation of the renin-angiotensin cascade begins with renin secretion from the juxtaglomerular apparatus of the kidney and culminates in the formation of angiotensin II, the primary active species of this system. This octapeptide, angiotensin II, is a potent vasoconstrictor agent and also produces other physiological effects such as promoting aldosterone secretion, promoting sodium and fluid retention, inhibiting renin secretion, increasing sympathetic nervous system activity, increasing vasopressin secretion, causing positive cardiac inotropic effect and modulating other hormonal systems. Previous studies have shown that antagonizing anqiotensin II at its receptors is a viable approach to inhibit the renin-angiotensin system, given the pivotal role of this octapeptide which mediates the actions of the renin-angiotensin system through interaction with various tissue receptors. There are several known angiotensin II antagonists, most of which are peptidic in nature. Such peptidic compounds are of limited use due to their lack of oral bioavailability or their short duration of action. Also, commercially-available peptidic angiotensin II antagonists (e.g., Saralasin) have a significant residual agonist activity which further limit their therapeutic application. Non-peptidic compounds with angiotensin II antagonist properties are known. For example, the sodium salt of 2-n-butyl-4-chloro-1-(2-chlorobenzyl)imidazole-5-acetic acid has specific competitive angiotensin II antagonist activity as shown in a series of binding experiments, functional assays and in vivo tests [P. C. Wong et al, J. Pharmacol. Exp. Ther. , 247 (1), 1-7 (1988)]. Also, the sodium salt of 2-butyl-4-chloro-1-(2-nitrobenzyl)imidazole-5-acetic acid has specific competitive angiotensin II antagonist activity as shown in a series of binding experiments, functional assays and in vivo tests [A. T. Chiu et al, European J. Pharmacol. , 157 , 13-21 (1988)]. A family of l-benzylimidazole-5-acetate derivatives has been shown to have competitive angiotensin II antagonist properties [A. T. Chiu et al, J. Pharmacol. Exp. Ther. , 250 (3), 867-874 (1989)]. U.S. Patent No. 4,816,463 to Blankey et al describes a family of 4,5,6,7-tetrahydro-1H-imidazo (4,5-c)-tetrahydro-pyridine derivatives useful as antihypertensives, some of which are reported to antagonize the binding of labelled angiotensin II to rat adrenal receptor preparation and thus cause a significant decrease in mean arterial blood pressure in conscious hypertensive rats. EP No. 253,310, published 20 January 1988, describes a series of aralkyl imidazole compounds, including in particular a family of biphenylmethyl substituted imidazoles, as antagonists to the angiotensin II receptor. EP No. 323,841 published 12 July 1989 describes four classes of angiotensin II antagonists, namely, biphenylmethylpyrroles, biphenylmethylpyrazoles, biphenylmethyl-1,2,3-triazoles and biphenylmethyl 4-substituted-4H-1,2,4-triazoles, including the compound 3,5-dibutyl-4-[(2'-carboxybiphenyl-4-yl)methyl]-4H-1,2,4-triazole. U.S. Patent No. 4,880,804 to Carini et al describes a family of biphenylmethylbenzimidazole compounds as angiotensin II receptor blockers for use in treatment of hypertension and congestive heart failure. There are several families of known compounds having one or two oxo substituents on a triazole ring. For example, East German Patent No. 160,447 published 3 August 1983 describes a family of 1,2,4-triazolin-5-one compounds, specifically 2,4-dihydro-4,5-bis(phenylmethyl)-3H-1,2,4-triazol-3-one, for use as herbicides. Belgian Patent No. 806,146 published 16 October 1972 describes a family of triazolinone compounds, including the compound (3-(4-m-chlorophenyl-1-piperazinyl)-propyl)-3,4-diethyl-1,2,4-triazolin-5-one, having tranquilizer, hypotensive and analgesic activities. Belgian Patent No. 631,842 published 28 February 1963 describes a family of 1,2,4-triazolones having hypnotic, tranquilizer, narcotic, sedative and analgetic activities, which includes a class of 4-N-aralkyl-1,2,4-triazol-5-one compounds. EP #7,180 published 15 June 1978 describes a family of 1,2-disubstituted-4-alkyl-1,2,4-triazolidine-3,5-dione compounds having a wide variety of activities, such as antiulcer, bronchodilator, antifertility and cardiovascular-related activities which include antihypertensive, antiarrhythmic, platelet aggregation inhibition and smooth muscle activities. EP #283,310 published 18 March 1987 describes a family of N 1 -diarylmethyl-N 2 -aminoalkyl-diaza-heterocyclic derivatives for treating cerebral vascular and ischemic diseases and for protecting against anoxia. EPA 0 399 731 is related to substituted oxaindenes which are useful as angiotensin-II-antagonists. EPA 0 411 507 discloses pyrazole-N-biphenyl substituted pyrazole-derivatives showing strong antagonistic actions to angiotensin II. EPA 0 407 102 decribes N-biphenyl substituted imidazo-fused 5-membered ring heterocycles useful as angiotensin-II-antagonists. EPA 0 475 898 is related to N-biphenyl substituted imidazol- or triazol-2-one compounds which are said to exhibit pharmacological activities. WO 91/18888 also describes N-biphenyl substituted 1,2,4-triazolone compounds useful in the treatment of cardiovascular disorders. EPA 0 412 594 discloses N-biphenyl substituted triazlinones, -triazolinethinones and -triazolinimines as angiotensin-ll-antagonists. EPA 0 409 332 is related to N-biphenyl substituted triazoles which are also useful as angiotensin-II-antagonists. EPA 0 399 732 and EPA 0 400 974 disclose N-phenyl substitued bezimidazoles and N-biphenyl substituted imidazofused 6-membered heterocycles, respectively, both useful as angiotensin-II-antagonists. Annu. Rep. Med. Chem. 21, 283 (1986), Chem. Soc. Rev. 8, 563 (1979) and Pharmazeutische Chemie, G.Thiene Verlag Stuttgart, 1982, pages 33-45 are relqted to possible bioisoterism in drug design. EPA 0 324 377 discloses N-phenyl substituted imidazole derivatives being antiotensin-II-receptor blocking. DESCRIPTION OF THE INVENTION A class of N-substituted arylheteroarylalkyl imidazol-2-one compounds useful in treating circulatory disorders, particularly cardiovascular disorders, is defined by Formula I: wherein A is selected from wherein R 1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclobutylmethyl, cyclobutylethyl, cyclopentylmethyl, cyclopentylethyl, cyclohexylmethyl, cyclohexylethyl cyclohexanoyl, methylbutyl, ethylbutyl, dimethylbutyl, thienylmethyl, thienylethyl, thienylpropyl, cyclopentenylmethyl, cyclopentenylethyl, cyclopentenylpropyl, cyclohexenyl, cyclohexenylmethyl, cyclohexenylethyl, adamantyl, adamantylmethyl, adamantylethyl, phenyl, chlorophenyl, dichlorophenyl, fluorophenyl, difluorophenyl, methoxyphenyl, ethoxyphenyl, methylphenyl, ethylphenyl, propylphenyl, isopropylphenyl, dimethylphenyl, diethylphenyl, benzyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R 2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, cert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclobutylmethyl, cyclobutylethyl, cyclopentylmethyl, cyclopentylethyl, cyclohexylmethyl, cyclohexylethyl, methylbutyl, ethylbutyl, dimethylbutyl, thienylmethyl, thienylethyl, thienylpropyl, cyclopentenylmethyl, cyclopentenylethyl, cyclopentenylpropyl, cyclohexenyl, cyclohexenylmetyl, cyclohexenylethyl, adamantyl, adamantylmethyl, adamantylethyl, phenyl, chlorophenyl, dichlorophenyl, fluorophenyl, difluorophenyl, methoxyphenyl, ethoxyphenyl, methylphenyl, ethylphenyl, propylphenyl, isopropylphenyl, dimethylphenyl, diethylphenyl, benzyl, propylthio, butylthio and hydroxyalkyl; wherein one of R 5 and R 9 is hydrogen and the other of R 5 and R 9 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. A preferred class of compounds are those selected from a family of compounds of Formula II wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio or hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Among these the following are especially preferred, namely compounds and their pharmaceutically-acceptable salts of the group of compounds consisting of 1-propyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one. Another group of preferred compounds are those selected from a family of compounds of Formula III wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio or hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Among these the following compounds and their pharmaceutically-acceptable salts are especially preferred: 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1,4-dipropyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-propyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-isopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl)methyl]-2H-imidazol-2-one; 1-butyl-4-pentyl-1,3-dihydro-3-[[6-(2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-cyclohexyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl)methyl]-2H-imidazol-2-one; 1-butyl-4-cyclopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-(2-cyclopropylethyl)-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-methyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl)methyl]-2H-imidazol-2-one; 1-ethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-propyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl)methyl]-2H-imidazol-2-one; 1-isobutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl]phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-isopropyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-tertbutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-neopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(3,3-dimethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl)methyl]-2H-imidazol-2-one; 1-cyclohexyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-cyclopropylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-cyclopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-cyclopentylmethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-[2-(2-thienyl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-cyclopentylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-[2-(cyclopenten-1-yl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(1-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-phenyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinylmethyl-2H-imidazol-2-one; 1-(2-chlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-methylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-methoxyphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-isopropylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2,6-difluorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2,6-dichlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; and 1-(2,6-dimethylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. A further group of preferred compounds are those selected from a family of compounds of Formula IV wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Among these the following compounds and their pharamaceutically-acceptable salts are preferred: 1-propyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. Still another group of preferred compounds consists of the family of compounds of Formula V wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Especially preferred are the following compounds and their pharmaceutically-accepcable salts: 1-propyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. A further preferred group consists of the family of compounds of Formula VI wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Preferred compounds and their pharmaceutically-acceptable salts are: 1-propyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. Still another preferred group consists of the family of compounds of Formula VII wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Among these the following compounds and their pharmaceutically-acceptable salts are especially preferred: 1-propyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. Highly preferred compounds are 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof; and 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1 H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. The present invention also embraces pharmaceutical compositions comprising a therapeutically-effective amount of an angiotensin-II antagonist and a pharmaceutically-acceptable carrier or diluent, said antagonist compound selected from a family of compounds as mentioned above. Among these compositions wherein the angiotensin II antagonist is 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof; or 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-(2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof are especially preferred. The compounds of the present invention, especially 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof or 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1 H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof may be used for preparing a medicament for treating a circulatory disorder, especially a cardiovascular disorder, e.g. hypertension or congestive heart failure. The term "hydroxyalkyl" embraces linear or branched alkyl groups having one to ten carbon atoms, any one of which may be substituted with one or more hydroxyl groups. Compounds of Formula I have been found to inhibit the action of angiotensin II in mammals. Angiotensin II is a potent vasoconstrictor and participates in the formation of aldosterone which regulates sodium and water balance in mammals. Thus, compounds of Formula I are therapeutically useful in methods for treating hypertension by administering to a hypertensive patient a therapeutically-effective amount of a compound of Formula I. The phrase "hypertensive patient" means, in this context, a mammalian subject suffering from or afflicted by the effects of hypertension or susceptible to a hypertensive condition if not treated to prevent or control such hypertension. Also included in the family of compounds of Formula I are isomeric forms including diastereoisomers, regioisomers and the pharmaceutically-acceptable salts thereof. The term "pharmaceutically-acceptable salts" embraces salts commonly used to form alkali metal salts and to form addition salts of free acids or free bases. The nature of the salt is not critical, provided that it is pharmaceutically-acceptable. Suitable pharmaceutically-acceptable acid addition salts of compounds of Formula I may be prepared from an inorganic acid or from an organic acid. Examples of such inorganic acids are hydrochloric, hydrobromic, hydroiodic, nitric, carbonic, sulfuric and phosphoric acid. Appropriate organic acids may be selected from aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic, carboxylic and sulfonic classes of organic acids, example of which are formic, acetic, propionic, succinic, glycolic, gluconic, lactic, malic, tartaric, citric, ascorbic, glucuronic, maleic, fumaric, pyruvic, aspartic, glutamic, benzoic, anthranilic, p-hydroxybenzoic, salicyclic, phenylacetic, mandelic, embonic (pamoic), methansulfonic, ethanesulfonic, 2-hydroxyethanesulfonic, pantothenic, benzenesulfonic, toluenesulfonic, sulfanilic, mesylic, cyclohexylaminosulfonic, stearic, algenic, β-hydroxybutyric, malonic, galactaric and galacturonic acid. Suitable pharmaceutically-acceptable base addition salts of compounds of Formula I include metallic salts made from aluminium, calcium, lithium, magnesium, potassium, sodium and zinc or organic salts made from N,N'-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N-methylglucamine) and procaine. All of these salts may be prepared by conventional means from the corresponding compound of Formula I by reacting, for example, the appropriate acid or base with the compound of Formula I. General Synthetic Procedures The compounds of the invention can be synthesized according to the following procedures of Schemes I-XXIX, wherein the R substituents are as defined for Formula I, above, except where further noted. Synthetic Scheme I shows the preparation of the boronic acid 1 where R 5 equals N-tertbutyl-N-methylcarboxamide. In step 1, benzoic acid is treated with thionyl chloride to give the corresponding acid chloride which is subsequently reacted with N-tertbutyl-N-methylamine to give N-tertbutyl-N-methylbenzamide. In step 2, the amide is ortho-metalated and subsequently reacted with trimethyl borate. The free boronic acid 1 is produced on hydroylsis. Synthetic Scheme II shows the preparation of the boronic acid 1 where R 5 equals N-triphenylmethyl-1H-tetrazole. In step 1, 2-bromobenzonitrile (Aldrich) is reacted with tributyltin azide to give the corresponding tetrazole. In step 2, the tetrazole is reacted with triphenylmethyl chloride in the presence of triethylamine to give the protected bromophenyltetrazole. In step 3, halogen-metal interchange with n-butyllithium generates the corresponding ortho-lithiated species which is reacted with trimethyl borate. The free boronic acid 1 is produced on hydrolysis. Synthetic Scheme III shows the preparation of N-Boc-amino- aldehydes 2 from the corresponding N-Boc-amino acides 3 . In step 1, the amino acid 3 is reacted with isobutyl chloroformate in the presence of triethylamine and subsequently with N,O-dimethylhydroxylamine to give the corresponding N-methoxy-N-methylamide 4 . In step 2, the amide 4 is reacted with lithium aluminum hydride (LAH) to give the desired aldehyde 2 . Synthetic Scheme IV shows the preparation of imidazol-2-ones 5 from the corresponding amides 4 via Method A. In step 1, the protected amide 4 (prepared in Scheme III) is reacted with trifluoroacetic acid (TFA) to give the TFA salt 6 of the free amine. In step 2, the salt 6 is reacted with the appropriate isocyanate 7 in the presence of triethylamine to give the urea 8 . In step 3, the urea 8 is reacted with lithium aluminum hydride (LAH) and subsequently cyclized to the imidazole-2-one 5 on treatment with dilute acid during the work-up procedure. Synthetic Scheme V shows the preparation of imidazol-2-ones 5 from the corresponding N-Boc-protected amino- aldehydes 2 via Method B. In step 1, the carbonyl compound 2 (prepared in Scheme III) is reacted with anhydrous hydrogen chloride in dioxane to give the HCl salt 9 . In step 2, the salt 9 is reacted with the appropriate isocyanate 7 in chloroform to give the imidazol-2-one 5 directly. Synthetic Scheme VI shows the preparation of imidazol-2-ones 5 from the corresponding N-Boc-protected amino- aldehydes 2 via Method C. In step 1, the carbonyl compound 2 (prepared in Scheme III) is reacted with 2,2-dimethyl-1,3-propandiol to give the cyclic ketal 10 . In step 2, the ketal 10 is reacted with TFA to give the TFA salt 11 of the free amine. In step 3, the salt 11 is reacted with the appropriate isocyanate 7 in the presence of triethylamine to give the urea ketal 12 . In step 4, the urea ketal 12 is reacted with 6N hydrochloric acid at 60°C to give the desired imidazol-2-one 5 directly. Synthetic Scheme VII shows the preparation of 2-bromomethyl-5-bromopyridine ( 13 ) and 5-bromo-2-pyridinecarboxaldehyde ( 14 ) from 2-picoline (Aldrich). In step 1, 2-picoline is reacted with bromine in the presence of a large excess of aluminum chloride at elevated temperatures to give 5-bromo-2-picoline ( 15 ). In step 2a, 15 is reacted with NBS to give the 2-pyridinylmethyl bromide 13 . In step 2b, the intermediate 15 is treated with potassium permanganate to give the corresponding picolinic acid 16 . In step 3b, the acid 16 is first converted to its N-methoxy-N-methylamide and subsequently reduced with LAH to provide 5-bromo-2-pyridinecarboxaldehyde ( 14 ). Synthetic Scheme VIII shows the preparation of 2-bromo-5-bromomethylpyridine ( 17 ) and 2-bromo-5-pyridinecarboxaldehyde ( 18 ) from 2-amino-5-picoline (Aldrich). In step 1, 2-amino-5-picoline is reacted with bromine in the presence of hydrobromic acid and sodium nitrite at 0°C to give 2-bromo-5-picoline ( 19 ). In step 2a, 19 is reacted with NBS to give the 3-pyridinylmethyl bromide 17 . In step 2b, the intermediate 19 is treated with potassium permanganate to give the corresponding nicotinic acid 20 . In step 3b, the acid 20 is first converted to its N-methoxy-N-methylamide and subsequently reduced with LAH to provide 2-bromo-5-pyridinecarboxaldehyde ( 18 ). Synthetic Scheme IX shows the preparation of (4-bromobenzyl)imidazol-2-ones 21 from the TFA salt of the amino amide 6 (prepared in Scheme III). In step 1, the TFA salt 6 is allowed to react with the 4-bromobenzaldehyde in the presence of triethylamine and anhydrous magnesium sulfate to give the imine 22 . In step 2, the imine 22 is allowed to react with sodium borohydride to give the substituted benzylamine 23 . In step 3, the benzylamine 23 is allowed to react with the appropriate isocyanate 7 to give the substituted benzylurea 24 . In step 4, the urea 24 is first allowed to react with lithium aluminum hydride (LAH) and subsequently with dilute aqueous acid to give the desired 3-(4-bromobenzyl)imidazol-2-ones. Synthetic Scheme X shows the preparation of 3-(5-bromo-2-pyridinylmethyl)imidazol-2-ones 25 from the TFA salt of the amino amide 6 (prepared in Scheme III). In step 1, the TFA salt 6 is allowed to react with the 5-bromo-2-pyridinylaldehyde 14 (prepared in Scheme VII) in the presence of triethylamine and anhydrous magnesium sulfate to give the imine 26 . In step 2, the imine 26 is allowed to react with sodium borohydride to give the substituted benzylamine 27 . In step 3, the benzylamine 27 is allowed to react with the appropriate isocyanate 7 to give the substituted benzylurea 28 . In step 4, the urea 28 is first allowed to react with lithium aluminum hydride (LAH) and subsequently with dilute aqueous acid to give the desired 3-(5-bromo-2-pyridinylmethyl)imidazol-2-ones 25 . Synthetic Scheme XI shows the preparation of 3-(2-bromo-5-pyridinylmethyl)imidazol-2-ones 29 from the TFA salt of the amino amide 6 (prepared in Scheme III). In step 1, the TFA salt 6 is allowed to react with 2-bromo-5-pyridinylaldehyde 18 (prepared in Scheme VIII) in the presence of triethylamine and anhydrous magnesium sulfate to give the imine 30 . In step 2, the imine 30 is allowed to react with sodium borohydride to give the substituted benzylamine 31 . In step 3, the benzylamine 31 is allowed to react with the appropriate isocyanate 7 to give the substituted benzylurea 32 . In step 4, the urea 32 is first allowed to react with lithium aluminum hydride (LAH) and subsequently with dilute aqueous acid to give the desired 3-(2-bromo-5-pyridinylmethyl)imidazol-2-ones 29 . Synthetic Scheme XII shows the preparation of 3-(4-bromobenzyl)imidazol-2-ones 21 , 3-(5-bromo-2-pyridinylmethyl)imidazol-2-ones 25 , and 3-(2-bromo-5-pyridinylmethyl)imidazol-2-ones 29 from the parent imidazol-2-ones 9 (prepared in Scheme IV, Scheme V, or Scheme VI). The imidazol-2-one 9 is first treated with a base, such as potassium t -butoxide, and subsequently with the alkylating agent 4-bromobenzyl bromide, 13 (prepared in Scheme VII), and 17 (prepared in Scheme VIII) to give 3-(4-bromobenzyl)imidazol-2-ones 21 , 3-(5-bromo-2-pyridinylmethyl)imidazol-2-ones 25 , and 3-(2-bromo-5-pyridinylmethyl)imidazol-2-ones 29 , respectively. Synthetic Scheme XIII shows the preparation of 3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-ones 30 from the boronic acid 1 (prepared in Scheme I and Scheme II) and the bromoimidazol-2-one coupling reagent 25 (prepared in Scheme X and Scheme XII). The boronic acid 1 is reacted with the bromoimidazol-2-one coupling reagent 25 in the presence of a palladium zero catalyst via a Snieckus coupling [see M. J. Sharp and V. Snieckus, Tetrahedron Lett. ., 5997(1985)] to give the angiotensin II antagonists 30 of this invention. Synthetic Scheme XIV shows the preparation of 3-[[6-[2-(1H-tetrzol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-ones 31 from the boronic acid 1 (prepared in Scheme I and Scheme II) and the bromoimidazol-2-one coupling reagent 29 (prepared in Scheme XI and Scheme XII). The boronic acid 1 is reacted with the bromoimidazol-2-one coupling reagent 29 in the presence of a palladium zero catalyst via a Snieckus coupling [see M. J. Sharp and V. Snieckus, Tetrahedron Lett. , 5997(1985)] to give the angiotensin II antagonists 31 of this invention. Synthetic Scheme XV shows the preparation of the imidazol-2-one boronic acid coupling reagents 32 from the corresponding 3-(4-bromobenzyl)imidazol-2-ones 21 (prepared in Scheme IX and Scheme XII). Halogen-metal interchange generates the corresponding lithiated species from 21 which is reacted with trimethyl borate. The free imidazol-2-one boronic acid coupling reagents 32 are produced on acid hydrolysis. Synthetic Scheme XVI shows the preparation of the 4-bromopyridine coupling reagent 33 [R 5 = CON(CH 3 )C(CH 3 ) 3 ] and the 2-bromopyridine coupling reagent 34 [R 5 = CON(CH 3 )C(CH 3 ) 3 ] from nicotinic acid. In step 1, N-tertbuty-N-methylnicotinamide is prepared from nicotinoyl chloride and N-tertbutyl-N-methylamine. In step 2, ortho-metalalion with sec-butyllithium gives a mixture of regioanions which are reacted with trimethylsilyl chloride; subsequent conversion to the corresponding bromides on treatment with bromine in acetic acid and separation of the regioisomers by chromatography provides 33 and 34 . Synthetic Scheme XVII shows the preparation of the 3-bromopyridine coupling reagent 35 [R 5 = CON(CH 3 )C(CH 3 ) 3 ] from isonicotinic acid. In step 1, N-tertbutyl-N-methylisonicotinamide is prepared from isonicotinoyl chloride and N-tertbutyl-N-methylamine. In step 2, reaction with sec-butyllithium gives the ortho-lithiated species which is reacted with trimethylsilyl chloride and subsequently converted to the corresponding bromide 35 on treatment with bromine in acetic acid. Synthetic Scheme XVIII shows the preparation of the 3-bromopyridine coupling reagent 36 [R 5 = CON(CH 3 )C(CH 3 ) 3 ] from picolinic acid. In step 1, N-tertbutyl-N-methylpicolinamide is prepared from picolinoyl chloride and N-tertbutyl-N-methylamine. In step 2, reaction with sec-butyllithium gives the ortho-lithiated species which is reacted with trimethylsilyl chloride and subsequently converted to the corresponding bromide 36 on treatment with bromine in acetic acid. Synthetic Scheme XIX shows the preparation of 3-(pyridinylbenzyl)imidazol-2-ones 37 , 38, 39 and 40 from the common imidazol-2-one boronic acids 32 (Scheme XV) and the corresponding bromo coupling reagents 36 (Scheme XVIII), 33 (Scheme XVI, 15 (Scheme XVII), and 34 (Scheme XVI), respectively. The boronic acids 32 are reacted with the bromo coupling reagents 36 , 33 , 35 and 34 in the presence of a palladium zero catalyst via a Snieckus coupling [see M. J. Sharp and V. Snieckus, Tetrahedron Lett ., 5997 (1985)] to give the angiotensin II antagonists 37 , 38 , 39 and 40 , respectively, of this invention. Synthetic Scheme XX shows the preparation of carboxylic acid analogs 41 and 1H-tetrazole analogs 42 from analogs which have R 5 = CON(CH 3 )C(CH 3 ) 3 . In step 1, the N-tertbutyl-N-methylamide analog 43 is reacted with trifluoroacetic acid at reflux to give the N-methylamide 44 . In step 2, the N-methylamide 44 is reacted with sodium nitrite in acetic anhydride/acetic acid at 0°C to give the corresponding N-methyl-N-nitrosoamide 45 . In step 3, the N-methyl-N-nitrosoamide 45 is hydrolyzed in base to give the corresponding carboxylic acid angiotensin II antagonists of this invention. In step 4, the acid analog 41 is reacted with oxalyl chloride and subsequently with anhydrous ammonia to give the primary amide 46 . In step 5, the amide 46 is reacted with triphenylphosphine in carbon tetrachloride at 50°C to give the corresponding nitrile 47 . In step 6, the nitrile 47 is reacted with trimethyltin azide in xylene at reflux to provide the 1H-tetrazole angiotensin II antagonists of this invention. Synthetic Scheme XXI shows the preparation of the organozinc reagent 48 from the appropriate benzoic acid analog 49 . In step 1, the analog 49 is brominated with bromine in the presence of a suitable catalyst, e.g., iron, to give the 2-bromo analog 50 . In step 2, the 2-bromo analog 50 was converted to the organolithium reagent 51 by reaction with n-butyllithium in THF at -78°C, a process known as halogen-metal interchange. Alternatively, the organolithium reagent 51 can be generated directly by the reaction of 49 with an alkyllithium reagent in the presence or absence of a suitable complexing agent in THF at -78°C, e.g., sec-butyllithium/TMEDA (N,N,N',N'-tetramethylethylenediamine). In step 3, the organolithium reagent 51 was treated with anhydrous zinc chloride at -78°C and subsequently allowed to warm to ambient temperature. The organozinc reagent 48 was generated and used in situ . Synthetic Scheme XXII shows the preparation of the 2-pyridinyl alkylating reagent 52 and the 3-pyridinyl alkylating 53 from 15 (Scheme VII) and 19 (Scheme VIII), respectively. In step 1, 15 and 19 were coupled with 1 using Snieckus conditions (Scheme XIII) or 48 using Negishi conditions [see E. Negishi, A. O. King, and N. Okukado, J. Org. Chem. , 42 , 1821 (1977)] to give 54 and 55 , respectively. In step 2, the coupled biaryl compounds 54 and 55 were brominated using NBS/AIBN to give the 2-pyridinyl alkylating reagent 52 and the 3-pyridinyl alkylating reagent 53 , respectively. Synthetic Scheme XXIII shows the preparation of 3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-ones 30 (R 5 =CN 4 H) and 3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-ones 31 (R 5 =CN 4 H) from the parent imidazol-2-ones 9 (prepared in Scheme IV, Scheme V, or Scheme VI). The imidazol-2-one 9 was first treated with a base, such as potassium t -butoxide, and subsequently with the alkylating reagent 52 or 53 (Scheme XXII) to give 3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-ones 30 (R 5 =CN 4 H) and 3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-ones 31 (R 5 =CN 4 H), respectively. Synthetic Scheme XXIV shows the preparation of 4-methylphenylboronic acid ( 56 ) from 4-bromotoluene. In step 1, the Grignard reagent was generated by the reaction of 4-bromotoluene with metallic magnesium in ether at reflux. In step 2, a THF solution of trimethoxyborane was cooled to -78° C and slowly treated with the Grignard reagent. In step 3, the boronic ester was hydrolyzed with aqueous hydrochloric acid to give 4-methylphenylboronic acid ( 56 ). Synthetic Scheme XXV shows the 8-step preparation of the alkylating reagent 2-(4-bromomethylphenyl)-3-cyanopyridine ( 57 ) from 2-amino-3-picoline ( 58 ) (Aldrich). In step 1, the aminopicoline 58 was converted to the bromopicoline 59 by reaction with bromine, concentrated hydrobromic acid, and sodium nitrite at 0°C. In step 2, the picoline 59 was oxidized with KMNO 4 to give the corresponding carboxylic acid 60 . In step 3, the acid 60 was reduced to the alcohol 61 with borane/THF. In step 4, the alcohol 61 was oxidized to the aldelyde 62 under Swern conditions or by using MnO 2 . In step 5, the aldehyde 62 was reacted with hydroxylamine to give the oxime 63 . In step 6, the oxime 63 was converted to 2-bromo-3-cyanopyridine ( 64 ) with acetic anhydride at reflux. In step 7, the nitrile 64 was coupled with 4-methylphenylboronic acid ( 56 ) (Scheme XXIV) using Snieckus conditions (Scheme XIII) to give 3-cyano-2-(4-methylphenyl)pyridine ( 65 ). In step 8, 65 was brominated with NBS/AIBN in carbon tetrachloride at reflux to give the desired alkylating reagent 57 . Synthetic Scheme XXVI shows the 6-step preparation of the alkylating reagent 3-(4-bromomethylphenyl)-4-cyanopyridine ( 66 ) from 4-picoline ( 67 ) (Aldrich). In step 1, 4-picoline was brominated with bromine in fuming sulfuric acid at high temperatures to give 3-bromo-4-picoline ( 68 ). In step 2, the picoline 68 was oxidized to the corresponding carboxylic acid 69 with KMnO 4 . In step 3, the acid 69 was first converted to its acid chloride with oxalyl chloride and subsequently treated with condensed ammonia to give the amide 70 . In step 4, the amide 70 was converted to 3-bromo-4-cyanopyridine ( 71 ) by treatment with P 2 O 5 at high temperatures. In step 5, the nitrile 71 was coupled with 4-methylphenylboronic acid ( 56 ) (Scheme XXIV) using Snieckus conditions (Scheme XIII) to give 4-cyano-3-(4-methylphenyl)pyridine ( 72 ). In step 6, 72 was brominated with NBS/AIBN in carbon tetrachloride at reflux to give the desired alkylating reagent 66 . Synthetic Scheme XXVII shows the 5-step preparation of the alkylating reagent 4-(4-bromomethylphenyl)-3-cyanopyridine ( 73 ) from 4-bromopyridine ( 74 ) (Aldrich). In step 1, the ortho-bromo carbanion was generated with LDA in THF at -78° C and reacted with anhydrous DMF to give 4-bromo-3-carboxaldehyde 75 . In step 2, the aldehyde 75 was reacted with hydroxylamine to give the oxime 76 . In step 3, the oxime 76 was dehydrated with 1,1'-carbonyldiimidazole in methylene chloride at reflux to give 4-bromo-3-cyanopyridine ( 77 ). In step 4, the nitrile 77 was coupled with 4-methylphenylboronic acid ( 56 ) (Scheme XXIV) using Snieckus conditions (Scheme XIII) to give 3-cyano-4-(4-methylphenyl)pridine ( 78 ). In step 5, 78 was brominated with NBS/AIBN in carbon tetrachloride at reflux to give the desired alkylating reagent 73 . Synthetic Scheme XXVIII shows the 4-step preparation of the alkylating reagent 2-cyano-3-(4-bromomethylphenyl)pyridine ( 79 ) from 3-bromopyridine ( 80 ) (Aldrich). In step 1, the pyridine 80 was reacted with hydrogen peroxide in acetic acid at reflux to give the pyridine N-oxide 81 . In step 2, the N-oxide 81 was converted to 3-bromo-2-cyanopyridine ( 82 ) by reaction with trimethysilylcyanide and triethyl anine in acetonitrile at reflux. In step 3, the nitrile 82 was coupled with 4-methylphenylboronic acid ( 56 ) (Scheme XXIV) using Snieckus conditions (Scheme XIII) to give 2-cyano-3-(4-methylphenyl) pyridine ( 83 ). In step 4, 83 was brominated with NBS/AIBN in carbon tetrachloride at reflux to give the desired alkylating reagent 79 . Synthetic Scheme XXIX shows the preparation of 1,4,5-trisubstituted-1,3-dihydro-3-[[4-(2-cyano-3-pyridinyl)phenyl]methyl]-2H-imidazol-2-ones 37 (R 5 =CN), 1,4,5-trisubstituted-1,3-dihydro-3-[[4-(3-cyano-4-pyridinyl)phenyl]methyl]-2H-imidazol-2-ones 39 (R 5 =CN), 1,4,5-trisubstituted-1,3-dihydro-3-[[4-(4-cyano-3-pyridinyl)phenyl]methyl]-2H-imidazol-2-ones 39 (R 5 =CN), and 1,4,5-trisubstituted-1,3,-dihydro-3-[[4-(3-cyano-2-pyridinyl)phenyl]methyl]-2H-imidazol-2-ones 40 (R 5 =CN) from the parent 1,4,5-trisubstituted-1,3-dihydro-2H-imidazol-2-ones 9 (prepared in Scheme IV, Scheme V, or Scheme VI). The imidazol-2-one 9 was first treated with a base, such as potassium t -butoxide, and subsequently with the alkylating reagents 79 (Scheme XXVIII), 73 (Scheme XXVII), 66 (Scheme XXVI), and 57 (Scheme XXV) to give the alkylated products 37 (R 5 =CN), 38 (R 5 =CN, 39 (R 5 =CN), and 40 (R 5 =CN), respectively. The following Examples contain detailed descriptions of the methods of preparation of compounds of Formula I. These detailed descriptions fall within the scope of, and serve to exemplify, the above described General Synthetic Procedures which form part of the invention. All parts are by weight and temperatures are in degrees Centigrade, unless otherwise indicated. Example 1 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of N-t-Boc-L-norleucine-N-methoxy-N-methylamide . Under nitrogen, a stirred solution of 400 g (1.73 mol) of N-t-Boc-norleucine (BACHEM) and 193 g (1.9 mol) of triethylamine (TEA) in 3000 mL of dichloromethane (DCM) at -50 °C was treated with 258 g (1.9 mol) of isobutyl chlorformate. After 30 min, 203 g (2.08 mol) of solid N,O-dimethylhydroxylamine hydrochloride was added followed by 210.5 g (2.08 mol) of TEA at such a rate as to maintain the reaction temperature at -35 °C. The reaction was stirred at -15 °C for 1 h and then allowed to warm to ambient temperature and stir overnight. The reaction was washed with 1 M citric acid, NaHCO 3 (sat), and brine. The solution was dried (Na2SO4) and concentrated in vacuo to give 499.3 g of crude product as a pale green oil: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.28-1.38 (m, 4H), 1.43 (s, 9H), 1.49-1.57 (m, 1H), 1.63-1.75 (m, 1H), 3.20 (s, 3H), 3.76 (s, 3H), 4.60-4.72 (m, 1H), 5.13 (d, J =8 Hz, 1H). Step 2A : Preparation of 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one: Method A . Under nitrogen, a stirred solution of 449 g of crude N-t-Boc-L-norleucine-N-methoxy-N-methylamide from Step 1 in 1350 mL of methylene chloride at 0 °C was treated with 1350 mL of trifluoroacetic acid (TFA). The reaction was allowed to warm to ambient temperature and stir. After 2 h, the reaction was concentrated in vacuo to give the TFA salt of L-norleucine-N-methoxy-N-methylamide as a viscous colorless oil: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.30-1.40 (m, 4H), 1.88 (t, J =7 Hz, 2H), 3.25 (s, 3H), 3.75 (s, 3H), 4.35-4.46 (m, 1H), 7.55-7.76 (br s, 3H). The TFA salt was cooled to 0 °C and treated with aqueous sodium hydroxide until the pH was 10. The resulting solution was continuously extracted with ether for 24 h, continuously extracted with ether/DCM (3:1) for 24 h, and continuously extracted with ether/DCM (1:1) for 24 h. The organic layer was dried (Na 2 SO 4 ) and concentrated in vacuo to give 245 g (83% from N-t-Boc-norleucine) as the monohydrate. Under nitrogen, a solution of this material in 100 mL of chloroform at 0°C was slowly treated with 208 g (2.1 mol) of neat n-butylisocyanate over 15 min. The reaction was allowed to warm to ambient temperature and stir for 3 h. The reaction was concentrated in vacuo; purification by silica gel chromatography (Waters Prep-500A) using ethyl acetate gave 299.5 g as a colorless oil: NMR (CDCl 3 ) δ 0.83-0.95 (m, 6H), 1.25-1.47 (m, 8H), 1.48-1.60 (m, 1H), 1.63-1.75 (m, 1H), 3.02-3.26 (m, 2H), 3.21 (s, 3H), 3.84 (s, 3H), 4.82-4.93 (m, 1H). Under nitrogen, 299 g (1.09 mol) of this material was dissolved in 600 mL of anhydrous diethyl ether; the solution was cooled to -15°C and slowly treated with 720 mL (720 mmol) of a 1.0 M solution of lithium aluminum hydride (LAH) in ether. The reaction was allowed to warm to ambient temperature and stir overnight prior to the addition of 50 mL of ethyl acetate. A solution of 285 g (2 mol) of potassium bisulfate in 1500 mL of water was added cautiously and the reaction stirred for 4 h. The reaction mixture was transferred to a separatory funnel and the phases separated. The aqueous phase was extracted 8 times with additional ether. The combined ether extracts were washed 3 times each with 3N hydrochloric acid, saturated sodium bicarbonate, and brine. The ether extracts were then dried (MgSO 4 ) and concentrated in vacuo to give 228 g (68% from N-t-Boc-norleucine) of 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one as a viscous colorless oil which solidified on storage in the refrigerator: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 0.93 (t, J =7 Hz, 3H), 1.28-1.41 (m, 4H), 1.47-1.65 (m, 4H), 2.36 (td, J =7 and 1 Hz, 2H), 3.55 (t, J =7 Hz, 2H), 5.84 (t, J =1 Hz, 1H), 9.78 (br s, 1H). Step 2B : Preparation of 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one: Method B. Under nitrogen, a stirred solution of 67.8 g (0.26 mol) of N-t-Boc-norleucine-N-methoxy-N-methylamide from Step 1 in 550 mL of anhydrous diethyl ether at 0 °C was treated with 145 mL (145 mmol) of a 1 M solution of lithium aluminum hydride (LAH) in ether over a 30 min period. The reaction was allowed to stir for an additional 30 min and then was quenched with the addition of 10 mL of ethyl acetate. The reaction was diluted with 1 L of cold water to which 63 g (0.46 mol) of potassium hydrogen sulfate had been added and the mixture stirred vigorously for 15 min. The phases were separated and the aqueous phase extracted 4 times with ether; the extracts were combined, washed 3 times with 3 N hydrochloric acid, once with saturated sodium bicarbonate, and once with brine, dried (Na 2 SO 4 ) and concentrated in vacuo to give 47.6 g (84%) of N-t-Boc-L-norleucinal as a colorless waxy solid: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.34-1.41 (m, 4H), 1.46 (s, 9H), 1.55-1.64 (m, 1H), 1.80-1.95 (m, 1H), 4.16-4.30 (m, 1H), 5.07-5.15 (m, 1H), 9.59 (s, 1H). Under nitrogen, a stirred solution of 10.0 g (46.4 mmol) of this material in 10 mL of dioxane (anhydrous) at 0 °C was treated with 120 mL (480 mmol) of 4 N hydrogen chloride in dioxane over a 10 min period. The reaction was allowed to stir at 0 °C for an additional 20 min after the addition was complete and then concentrated in vacuo . The residue was dissolved in 200 mL of chloroform and treated with 77.4 g (0.78 mol) of butyl isocyanate. The mixture was stirred at ambient temperature for 24 h, stirred at 40 °C for 24 h, and concentrated in vacuo . Purification of the reddish colored residue by silica gel chromatography (Harrison Chromatotron) using ethyl acetate/2-propanol (95:5) gave 160 mg (1.7% from N-t-Boc-L-norleucinal) of 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one as an yellowish oil: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 0.93 (t, J =7 Hz, 3H), 1.28-1.41 (m, 4H), 1.47-1.65 (m, 4H), 2.36 (td, J =7 and 1 Hz, 2H), 3.55 (t, J =7 Hz, 2H), 5.84 (t, J =1 Hz, 1H), 9.78 (br s, lH); MS (FAB) m/e (rel intensity) 197 (100), 153 (12), 141 (12), 125 (8), 111 (7). Step 2C : Preparation of 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one: Method C. Under nitrogen, a solution of 27.0 g (125 mmol) of N-t-Boc-L-norleucinal from step 2B, 39.1 g (376 mmol) of 2,2-dimethyl-1,3-propanediol, and 1.18 g (6.2 mmol) of p-toluenesulfonic acid monohydrate in 220 mL of benzene was stirred at reflux for 22 h over a Dean-Stark trap. The reaction was cooled, diluted with 300 mL of ethyl acetate, washed sequentially with saturated sodium bicarbonate and brine, dried (Na 2 SO 4 ), and concentrated in vacuo to give 38.27 g of crude ketal which was a red oil: NMR (CDCl 3 ) δ 0.71 (s, 3H), 0.89 (t, J =7Hz 3H), 1.16 (s, 3H), 1.20-1.52 (m, 5H), 1.45 (s, 9H), 1.58-1.72 (m, 1H), 3.35-3.46 (m, 2H), 3.56-3.63 (m, 2H), 4.43 (s, 1H), 4.66 (d, J =9Hz, 1H). Under nitrogen, a 38.2 g sample of the crude ketal was dissolved in 200 mL of methylene chloride; the solution was cooled to 0 °C and treated with 200 mL of trifluoracetic acid. The reaction was allowed to warm to ambient temperature and stir for 2 h. Concentration in vacuo gave the crude TFA salt of the free amino ketal as a red viscous oil: NMR (CDCl 3 ) δ 0.75 (s, 3H), 0.90 (t, J =7 Hz, 3H), 1.13 (s, 3H), 1.27-1.42 (m, 4H), 1.60-1.82 (m, 2H), 3.27-3.38 (m, 1H), 3.42-3.52 (m, 2H), 3.63-3.72 (m, 2H), 4.58 (d, J =3 Hz, 1H), 7.1-7.5 (br s, 3H). Under nitrogen, the crude TFA salt was redissolved in 100 mL of methylene chloride and treated with 264 g (2.66 mol) of butyl isocyanate. The reaction was stirred at ambient temperature for 17 h. The reaction was concentrated in vacuo to give the crude N-butyl urea of the ketal as a red oil. Purification of a small sample by silica gel chromatography (Harrison Chromatotron) using ethyl acetate/hexane (1:1) gave the pure N-butyl urea as a pale yellow oil: NMR (CDCl 3 ) δ 0.71 (s, 3H), 0.89 (t, J =7 Hz, 3H), 0.92 (t, J =7 Hz, 3H), 1.16 (s, 3H), 1.23-1.54 (m, 9H), 1.61-1.75 (m, 1H), 3.09-3.21 (m, 2H), 3.37-3.46 (m, 2H), 3.56-3.64 (m, 2H), 3.68-3.79 (m, 1H), 4.32-4.47 (br s, 1H), 4.42 (d, J =3 Hz, 1H). Under nitrogen, a solution of the crude N-butyl urea ketal in 1 L of 1,4-dioxane was treated with 1 L of 6 N hydrochloric acid. The reaction was allowed to stir at ambient temperature for 16 h and then warmed to 60 °C and stirred for an additional 24 h. The reaction was concentrated in vacuo ; the residue was treated with ethyl acetate and filtered. The ethyl acetate solution was dried (MgSO 4 ) and concentrated in vacuo to give the crude product. Purification by silica gel chromatography (Waters Prep-500A) using methylene chloride/2-propanol (95:5) gave 4.95 g (20% from N-t-Boc-L-norleucinal) of 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one as a pale yellow oil: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 0.93 (t, J =7 Hz, 3H) 1.28-1.41 (m, 4H), 1.47-1.65 (m, 4H), 2.36 (td, J =7 and 1 Hz, 2H), 3.55 (t, J =7 Hz, 2H), 5.84 (t, J =1 Hz, 1H), 9.78 (br s, 1H). Step 3 : Preparation of 2-bromo-5-picoline . A solution of 1500 mL (14 mol) of 48% hydrobromic acid was cooled to 10 °C and 300 g (2.8 mol) of 2-amino-5-picoline (Aldrich) was added slowly. The solution was maintained at or below 0 °C while 450 mL (8.8 mol) of bromime was added dropwise. After the bromine addition was complete, a solution of 500 g (7.3 mol) of sodium nitrite in 1000 mL of water was added slowly over 6 h. The reaction pH was adjusted by the careful addition of 1500 mL (56 mol) of 50% sodium hydroxide at such a rate that the temperature was maintained below 30 °C. The product precipitated from the nearly colorless reaction mixture; filtration gave 450 g (94%) of 2-bromo-5-picoline as a yellow powder: mp 38-40 °C; NMR 7.27 (s, 1H), 7.28 (s, 1H), 7.12 (br s, 1H). Step 4 : Preparation of 2-bromo-5-bromomethylpyridine . A solution of 296.3 g (1.72 mol) of 2-bromo-5-picoline from step 3 in 6 L of carbon tetrachloride was treated with 306.5 g (1.72 mol) of N-bromosuccinimide (NBS) and 28.3 g (173 mmol) of azobisisobutyronitrile (AIBN). The reaction was stirred at reflux under nitrogen for 3 h, filtered, and concentrated in vacuo providing 476 g of crude 2-bromo-5-bromomethylpyridine as a brownish yellow solid (NMR indicates that this material is only 69% monobromomethyl product): NMR (CDCl 3 ) δ 4.42 (s, 2H), 7.48 (d, J =9 Hz, 1H), 7.60 (dd, J =9 and 3 Hz, 1H), 8.37 (d, J =3 Hz, 1H). Step 5 : Preparation of 1,4-dibutyl-1,3-dihydro-3-[(6-bromo-3-pyridinyl)methyl]-2H-imidazol-2-one . Under nitrogen, 138 mL (138 mmol) of 1.0 M potassium t-butoxide in THF was added to a stirred solution of 24.5 g (125 mmol) of 1,4-dibutylimidazol-2-one from step 2A in 370 mL of DMF at -30 °C at such a rate to maintain the solution temperature below -20 °C. After 10 min, 50 g [138 mmol (69% purity)] of 2-bromo-5-bromomethylpyridine from step 4 and 2.7 g (18.1 mmol) of sodium iodide were added. The reaction was stirred at 0 °C for 2 h and then allowed to slowly warm to ambient temperature overnight. The reaction was partitioned between ethyl acetate and water; the organic layer was washed twice with brine and the combined aqueous phases were back-extracted with ethyl acetate. The ethyl acetate extractions were combined, dried (MgSO 4 ), and concentrated in vacuo . Purification by silica gel chromatography (Waters Prep-500A) using hexane/ethyl acetate (25:75) gave 33 g (73%) of 1,4-dibutyl-1,3-dihydro-3-[(6-bromo-3-pyridinyl)methyl]-2H-imdazol-2-one as a reddish-brown waxy solid: NMR (CDCl 3 ) δ 0.89 (t, J =7 Hz, 3H), 0.95 (t, J =7 Hz, 3H), 1.25-1.51 (m, 6H), 1.57-1.71 (m, 2H), 2.22 (t, J =8 Hz, 2H), 3.60 (t, J =7 Hz, 2H), 4.80 (s, 2H), 5.90 (s, 1H), 7.43 (d, J =9 Hz, 1H), 7.49 (dd, J =9 and 2 Hz, 1H), 8.24 (d, J =2Hz, 1H). Step 6: Preparation of 2-(N-triphenylmethyltetrazol-5-yl)phenylboronic acid . A 64 g (350 mmol) sample of 2-bromobenzonitrile (Aldrich) was dissolved in 650 mL of xylene and treated with 22.75 g (350 mmol) of sodium azide and 95 mL (350 mmol) of tributyltin chloride at reflux for 48 h. The reaction was filtered; the filtrate was treated with 50 mL of anhydrous tetrahydrofuran (THF) and 20 g (550 mmol) of hydrogen chloride. The reaction was stirred for 2 h; filtration gave 59.6 g (76%) of 5-(2-bromophenyl)-1H-tetrazole: mp 178-180 °C; NMR (DMSO-d 6 ) δ 7.50-7.64 (m, 2H), 7.67-7.74 (m, 1H), 7.83-7.91 (m, 1H). A 41.8 g (187 mmol) sample of this material was dissolved in 650 mL of methylene chloride and treated with 55.5 g (193 mmol) of triphenylmethyl chloride and 30 mL (220 mmol) of anhydrous triethylamine. The reaction was stirred overnight at reflux, cooled to ambient tempeature, washed with water, dried (MgSO 4 ), and concentrated in vacuo . Recrystallization from toluene/hexane gave 80.7 g (92%) of N-triphenylmethyl-5-(2-bromophenyl)-1H-tetrazole: mp 160-162 °C; NMR (CDCl 3 ) δ 7.14-7.21 (m, 6H), 7.26-7.45 (m, 11H), 7.70 (dd, J =8 and 1.5 Hz, 1H), 7.89 (dd, J =7.5 and 2 Hz, 1H). A 34.05 g (73.0 mmol) sample of this material was dissolved in 1700 mL of THF under a nitrogen atmosphere and treated with 73 mmol of n-butyllithium in hexane. The reaction was allowed to stir for 17 min and then was treated with 24.9 mL (220 mmol) of trimethyl borate. The reaction was allowed to come to ambient temperature overnight while stirring, quenched with 10 mL of methanol, and concentrated in vacuo . The residue was dissolved in 1M NaOH and extracted with toluene to remove any unreacted starting material. The pH was adiusted to 6 with 6M HCl and the product extracted with toluene and dried (MgSO 4 ). Hexane was added and the solution kept in the freezer overnight. Filtration provided 31.3 g (99%) of 2-(N-triphenylmethyltetrazol-5-yl)phenylboronic acid: NMR (CDCl 3 ) δ 7.13-7.21 (m, 7H), 7.33-7.42 (m, 8H), 7.49-7.55 (m, 2H), 8.15-8.19 (m, 1H), 8.21-8.26 (m, 1H). Step 7 : Preparation of 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one . A solution of 21.7 g (50.2 mmol) of 2-(N-triphenylmethyltetrazol-5-yl)phenylboronic acid from step 6 in 80 mL of ethanol and 130 mL of toluene was added to a mixture of 5 g (4 mmol) of tetrakis(triphenylphosphine) Pd(0), 16.75 g (45.8 mmol) of 1,4-dibutyl-1,3-dihydro-3-[(6-bromo-3-pyridinyl)methyl]-2H-imidazol-2-one from step 5, 225 mL of toluene, 100 mL of 2 M sodium carbonate, and 150 mL of ethanol. The reaction mixture was heated to reflux and vigorously stirred under nitrogen for 14 h. The pH was adjusted to 6 with acetic acid and the reaction concentrated in vacuo . The product was purified by silica gel chromatography (Waters Prep-500A) using 2-propanol/methylene chloride (0-50%) followed by reverse phase chromatography (Waters Deltaprep-3000) using acetonitrile/water (30-35:70-65) (0.05% TFA). The pure fractions (by analytical HPLC) were combined, the acetonitrile removed in vacuo , and the water extracted 4 times with chloroform. The extracts were combined, dried (MgSO 4 ), and concentrated in vacuo . Recrystallization from ethyl acetate gave 8.5 g (43%) of colorless 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 170-171°C; NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 0.96 (t, J =7 Hz, 3H), 1.28-1.54 (m, 6H), 1.61-1.72 (m, 2H), 2.28 (t, J =8 Hz, 2H), 3.63 (t, J =7 Hz, 2H), 4.96 (s, 2H), 5.96 (s, 1H), 7.36 (d, J =9 Hz, 1H), 7.47-7.58 (m, 3H), 7.67 (dd, J =9 and 2 Hz, 1H), 8.06-8.13 (m, 1H), 8.52 (d, J ,=2 Hz, 1H); MS (FAB) m/e (rel intensity) 432 (100), 404 (18), 237 (14), 209 (92), 180 (82); HRMS. Calc'd for M+H: 432.2512. Found: 432.2554. Anal . Calc'd for C 24 H 29 N 7 O: C, 66.80; H, 6.77; N, 22.72. Found: C, 66.59; H, 6.85; N, 22.57. Example 2 1,4-dipropyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1,4-dipropyl-1,3-dihydro-2H-imidazol-2-one . Following General Synthetic Schemes III and IV, 1,4-dipropyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.92 (t, J =7 Hz, 3H), 0.93 (t, J =7 Hz, 3H), 1.57 (m, J =7 Hz, 2H), 1.67 (m, J =7 Hz, 2H), 2.34 (td, J =7 and 1 Hz, 2H), 3.52 (t, J =7 Hz, 2H), 5.86 (t, J =1 Hz, 1H), 10.06 (br s, 1H); MS (FAB) m/e (rel intensity) 169 (100), 153 (4), 139 (9), 127 (9); HRMS. Calc'd for M+H: 169.1341. Found 169.1346. Step 2 : Preparation of 1,4-dipropyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1,4-dipropyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ0.94 (t, J =7 Hz, 3H), 0.95 (t, J =7 Hz, 3H), 1.53 (m, J =7 Hz, 3H), 1.71 (m, J =7Hz, 2H), 2.27 (td, J =7 and 1 Hz, 2H), 3.60 (t, J =7 Hz, 2H), 4.95 (s, 2H), 5.97 (t, J =1 Hz, 1H), 7.33 (d, J =8 Hz, 1H), 7.47-7.57 (m, 3H), 7.64 (dd, J =8 and 2 Hz, 1H), 8.04-8.11 (m, 1H), 8.52 (d, J =2Hz, 1H); MS (FAB) m/e (rel intensity) 404 (83), 376 (22), 347 (8), 237 (7), 209 (100), 180 (98); HRMS. Calc'd for M+H: 404.2199. Found: 404.2177. Example 3 1-propyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-propyl-4-isobutyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-propyl-4-isobutyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ0.91 (d, J =7 Hz, 6H), 0.93 (t, J =7 Hz, 3H), 1.60-1.72 (m, 2H), 1.83 (m, J =7 Hz, 1H), 2.21 (d, J =7 Hz, 2H), 3.52 (t, J =7 Hz, 2H), 5.84-5.87 (m, 1H), 9.78 (br s, 1H); MS (FAB) m/e (rel intensity) 183 (100), 167 (4), 153 (2), 139 (15); HRMS. Calc'd for M+H: 183.1497. Found: 183.1492. Step 2 : Preparation of 1-propyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-propyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.90 (d, J =7 Hz, 6H), 0.95 (t, J =8 Hz, 3H), 1.62-1.78 (m, 3H), 2.16 (dd, J =7 and 1 Hz, 2H), 3.61 (t, J =7 Hz, 2H), 4.97 (s, 2H), 5.98 (s, 1H), 7.30 (d, J =8 Hz, 1H), 7.45-7.55 (m, 3H), 7.60 (dd, J =8 and 2Hz, 1H), 8.01-8.07 (m, 1H), 8.49 (d, J =2Hz, 1H); MS (FAB) m/e (rel intensity) 418 (45), 390 (15), 375 (4), 361 (4), 237 (10), 209 (93), 195 (36), 180 (100); HRMS. Calc'd for M+H: 418.2355. Found: 418.2383. Example 4 1-butyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-butyl-4-isobutyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-butyl-4-isobutyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ0.91 (d, J =7 Hz, 6H), 0.94 (t, J =7 Hz, 3H), 1.28-1.41 (m, 2H), 1.57-1.68 (m, 2H), 1.75-1.87 (m, 1H), 2.21 (d, J =7 Hz, 2H), 3.55 (t, J =7 Hz, 2H), 5.86 (s, 1H), 8.86 (br s, 1H); MS (FAB) m/e (rel intensity) 197 (100), 181 (6), 173 (5), 167 (3), 153 (30), 141 (20), 125 (6), 111 (5); HRMS. Calc'd for M+H: 197.1654. Found: 197.1637. Step 2 : Preparation of 1-butyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-butyl-4-isobutyl-1,3-dihydro-3-[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (DMSO-d 6 ) δ0.82 (d, J =6 Hz, 6H), 0.88 (t, J =7 Hz, 3H), 1.17-1.32 (m, 3H), 1.49-1.65 (m, 2H), 2.21 (d, J =7 Hz, 2H), 3.52 (t, J =7 Hz, 2H), 4.81 (s, 2H), 6.29 (s, 1H), 7.45 (d, J =8 Hz, 1H), 7.58-7.79 (m, 5H), 8.25 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 432 (65), 404 (20), 375 (5), 237 (20), 209 (100), 194 (30), 180 (65); HRMS. Calc'd for M+H: 432.2512. Found: 432.2562. Example 5 1-butyl-4-isopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-butyl-4-isopentyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-butyl-4-isopentyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ0.90 (d, J =7 Hz, 6H), 0.93 (t, J =7 Hz, 3H), 1.26-1.67 (m, 7H), 2.35 (t, J =7 Hz, 2H), 3.54 (t, J =7 Hz, 2H), 5.83 (br s, 1H), 9.40 (br s, 1H); MS (FAB) m/e (rel intensity) 211 (100), 195 (8), 167 (15), 153 (25), 132 (8), 111 (20); HRMS. Calc'd for M+H: 211.1810. Found: 211.1802. Step 2 : Preparation of 1-butyl-4-isopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-butyl-4-isopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ0.87 (d, J =7 Hz,6H), 0.95 (t, J =7 Hz, 3H), 1.30-1.43 (m, 4H), 1.50-1.72 (m, 3H), 2.28 (t, J =8 Hz, 2H), 3.62 (t, J =7 Hz, 2H), 4.97 (s, 2H), 5.95 (s, 1H), 7.32 (d, J =9 Hz, 1H), 7.46-7.56 (m, 3H), 7.69 (dd, J =9 and 2Hz, 1H), 7.97-8.03 (m, 1H), 8.48 (br s, 1H); MS (FAB) m/e (rel intensity) 446 (100), 418 (25), 237 (15), 209 (75), 180 (65); HRMS. Calc'd for M+H: 446.2669. Found : 446.2654. Example 6 1-butyl-4-pentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-butyl-4-pentyl-1,3-dihydro-2H-imidazol-z-one. Following General Synthetic Schemes III and IV, 1-butyl-4-pentyl-1,3,-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 0.92 (t, J =7 Hz, 3H),1.24-1.43 (m, 6H), 1.47-1.70 (m, 4H), 2.35 (t, J =7 Hz, 2H), 3.55 (t, J =7 Hz, 2H), 5.82-5.87 (m, 1H), 9.60 (br s, 1H); MS (FAB) m/e (rel intensity) 211 (100), 155 (15); HRMS. Calc'd for M+H: 211.1810. Found: 211.1796. Step 2 : Preparation of 1-butyl-4-pentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-butyl-4-pentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 176-177° C; NMR (CDCl 3 ) δ0.87 (t, J =7 Hz, 3H), 0.96 (t, J =8 Hz, 3H), 1.24-1.43 (m, 6H), 1.45-1.56 (m, 2H), 1.61-1.72 (m, 2H), 2.29 (t, J =8 Hz, 2H), 3.63 (t, J =8 Hz, 2H), 4.96 (s, 2H), 5.97 (s, 1H), 7.45 (d, J =8 Hz, 1H), 7.50-7.62 (m, 3H), 7.79 (dd, J =8 and 2 Hz, 1H), 8.11-8.18 (m, 1H), 8.55 (d, J =2 Hz); MS (FAB) m/e (rel intensity) 446 (76), 418 (27), 403 (8), 390 (8), 389 (8), 237 (25), 209 (100), 194 (35), 180 (79);HRMS. Calc'd for M+H: 446.2668. Found: 446.2677. Example 7 1-butyl-4-cyclohexyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-butyl-4-cyclohexyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-butyl-4-cyclohexyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ0.93 (t, J =7 Hz, 3H), 1.12-1.42 (m, 8H), 1.55-1.84 (m, 8H), 1.84-1.95 (m, 2H), 2.25-2.38 (m, 1H), 3.54 (t, J =7 Hz, 2H), 5.79 (q, J =1 Hz, 1H), 8.97 (br s, 1H); MS (FAB) m/e (rel intensity) 223 (100). HRMS. Calc'd for M+H: 223.1810. Found: 223.1811. Step 2 : Preparation of 1-butyl-4-cyclohexyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-butyl-4-cyclohexyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.96 (t, J =7 Hz, 3H), 1.12-1.45 (m, 8H), 1.57-1.89 (m, 8H), 2.20-2.23 (m, 1H), 3.62 (t, J =7 Hz, 2H), 5.02 (s, 2H), 5.96 (s, 1H), 7.53-7.68 (m, 4H), 8.03 (d, J =8 Hz, 1H), 8.12-8.19 (m, 1H), 8.59 (d, J=2 Hz, 1H); MS (FAB) m/e (rel intensity) 458 (70), 430 (20), 222 (20); HRMS. Calc'd for M+H: 458.2668. Found: 458.2676. Example 8 1-butyl-4-cyclopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-butyl-4-cyclopentyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-butyl-4-cyclopentyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.94 (t, J =7 Hz, 3H), 1.17-1.42 (m, 4H), 1.42-1.80 (m, 6H), 1.89-2.01 (m, 2H), 2.64-2.93 (m, 1H), 3.55 (t, J =7 Hz, 2H), 5.84 (q, J =1 Hz, 1H), 9.90 (br s, 1H); MS (FAB) m/e (rel intensity) 209 (100), 153 (10); HRMS. Calc'd for M+H: 209.1654. Found: 209.1725. Step 2 : Preparation of 1-butyl-4-cyclopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-butyl-4-cyclopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 195-196° C (dec); NMR (CDCl 3 ) δ0.95 (t, J =8 Hz, 3H), 1.30-1.49 (m, 4H), 1.53-1.77 (m, 6H), 1.83-1.95 (m, 2H), 2.61-2.74 (m, 1H), 3.62 (t, J =8 Hz, 2H), 5.01 (s, 2H), 5.97 (d, J =1 Hz, 1H), 7.37 (d, J =8 Hz, 1H), 7.48-7.58 (m, 3H), 7.70 (dd, J =8 and 2 Hz, 1H), 8.03-8.10 (m, 1H), 8.52 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 444 (57), 416 (17), 237 (20), 209 (100), 194 (34), 180 (70); HRMS. Calc'd for M+H: 444.2512. Found: 444.2487. Example 9 1-butyl-4-(2-cyclopropylethyl)-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-butyl-4-(2-cyclopropylethyl)-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-butyl-4-(2-cyclopropylethyl)-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ0.00-0.07 (m, 2H), 0.37-0.45 (m, 2H), 0.61-0.76 (m, 1H), 0.92 (t, J =7 Hz, 3H), 1.28-1.48 (m, 4H), 1.55-1.67 (m, 2H), 2.46 (t, J =7 Hz, 2H), 3.54 (t, J =7 Hz, 2H), 5.82-5.86 (m, 1H), 10.0 (br s, 1H); MS (FAB) m/e (rel intensity) 209 (100), 193 (4), 179 (3), 165 (8), 153 (30), 137 (4), 123 (4), 111 (10); HRMS. Calc'd for M+H: 209.1654. Found: 209.1721. Step 2 : Preparation of 1-butyl-4-(2-cyclopropylethyl)-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-butyl-4-(2-cyclopropylethyl)-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.00-0.07 (m, 2H), 0.40-0.47 (m, 2H), 0.63-0.77 (m, 1H), 0.94 (t, J =7 Hz, 3H), 1.03-1.45 (m, 4H), 1.65 (m, J =7 Hz, 2H), 2.40 (t, J =7 Hz, 2H), 3.62 (t, J =7 Hz, 2H), 4.99 (s, 2H), 5.97 (s, 1H), 7.35 (d, J =8 Hz, 1H), 7.48-7.56 (m, 3H), 7.74 (dd, J =8 and 2 Hz, 1H), 7.97-8.04 (m, 1H), 8.50 (d, J =1 Hz, 1H); MS (FAB) m/e (rel intensity) 444 (100), 416 (16), 401 (9), 388 (5), 237 (14), 209 (33), 194 (16), 180 (35); HRMS. Calc'd for M+H: 444.2512. Found: 444.2513. Example 10 1-methyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-methyl-4-butyl-1,3,-dihvdro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-methyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.89 (t, J =7 Hz, 3H), 1.26-1.40 (m, 2H), 1.45-1.56 (m, 2H), 2.34 (t, J =8 Hz, 2H), 3.18 (s, 3H), 5.79-5.83 (m, 1H), 10.18 (br s, 1H). Step 2 : Preparation of 1-methyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-methyl-4-butyl-1,3,-dihydro-3-[[6-[2(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 184-185° C (dec); NMR (CDCl 3 ) δ 0.88 (t, J =8 Hz, 3H), 1.28-1.54 (m, 4H), 2.29 (t, J =8 Hz, 2H), 3.28 (s, 3H), 4.97 (s, 1H), 5.95 (s, 1H), 7.38 (d, J =8 Hz, 1H), 7.47-7.59 (m, 3H), 7.74 (dd, J =8 and 2 Hz, 1H), 8.04-8.11 (m, 1H), 8.53 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 390 (100), 362 (12), 237 (17), 209 (46), 194 (18), 180 (40); HRMS. Calc'd for M+H: 390.2042. Found 390.2021. Example 11 1-ethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-ethyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-ethyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.90 (t, J =7 Hz, 3H), 1.24-1.41 (m, 2H), 1.27 (t, J =8 Hz, 3H), 1.44-1.58 (m, 2H), 2.35 (t, J =8 Hz, 2H), 3.59 (q, J =8 Hz, 2H), 5.83-5.86 (m, 1H), 10.13 (br s, 1H); MS (FAB) m/e (rel intensity) 169 (100), 141 (4), 139 (5), 125 (17); HRMS. Calc'd for M+H: 169.1341. Found: 169.1365. Step 2 : Preparation of 1-ethyl-1-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-ethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 205° C (dec); NMR (CDCl 3 ) δ 0.89 (t, J =7 Hz, 3H), 1.27-1.55 (m, 4H), 1.30 (t, J =8 Hz, 3H), 2.31 (t, J =8 Hz, 2H), 3.69 (q, J =8 Hz, 2H), 4.98 (s, 2H), 6.00 (t, J =1 Hz, 1H), 7.46 (d, J =8 Hz, 1H), 7.52-7.62 (m, 3H), 7.84 (dd, J =8 and 2 Hz, 1H), 8.08-8.15 (m, 1H), 8.55 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 404 (93), 376 (20), 237 (18), 209 (100), 194 (30), 180 (80), 168 (26); HRMS. Calc'd for M+H: 404.2199. Found: 404.2257. Example 12 1-propyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-propyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-propyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.87 (t, J =7 Hz, 3H), 0.90 (t, J =7 Hz, 3H), 1.25-1.39 (m, 2H), 1.44-1.56 (m, 2H), 1.58-1.61 (m, 2H), 2.34 (td, J =8 and 1 Hz, 2H), 3.49 (t, J =8 Hz, 2H), 5.82 (t, J =1 Hz, 1H), 10.33 (br s, 1H); MS (FAB) m/e (rel intensity) 183 (100), 141 (13), 139 (15); HRMS. Calc'd for M+H: 183.1497. Found 183.1497. Steps 2 : Preparation of 1-propyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-propyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 164-165° C; NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 0.94 (t, J =7 Hz, 3H), 1.29-1.55 (m, 4H), 1.63-1.77 (m, 2H), 2.30 (td, J =8 and 1 Hz, 2H), 3.60 (t, J =8 Hz, 2H), 4.97 (s, 1H), 5.98 (t, J =1 Hz, 1H), 7.43 (d, J =8 Hz, 1H), 7.50-7.61 (m, 3H), 7.80 (dd, J =8 and 2 Hz, 1H), 8.05-8.12 (m, 1H), 8.53 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 418 (100), 390 (12), 209 (20), 180 (21); HRMS. Calc'd for M+H: 418.2355. Found: 418.2312. Example 13 1-isobutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-isobutyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-isobutyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.90 (t, J =7 Hz, 3H), 0.92 (d, J =7 Hz, 6H), 1.27-1.41 (m, 2H), 1.46-1.58 (m, 2H) 1.97 (m, J =7 Hz, 1H), 2.36 (td, J =8 and 1 Hz, 2H), 3.36 (d, J =8 Hz, 2H), 5.84 (t, J =1 Hz, 1H), 9.86 (br s, 1H); MS (FAB) m/e (rel intensity) 197 (100), 141 (22); HRMS. Calc'd for M+H: 197.1654. Found: 197.1635. Step 2: Preparation of 1-isobutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-isobutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 160.0-161.5° C; NMR (CDCl 3 ) δ 0.87 (t, J =7 Hz, 3H), 0.92 (d, J =7 Hz, 6H), 1.27-1.53 (m, 4H), 1.99 (m, J =7 Hz, 1H), 2.28 (t, J =8 Hz, 2H), 3.43 (d, J =7 Hz, 2H), 4.97 (s, 2H), 5.93 (s, 1H), 7.27 (d, J =8 Hz, 1H), 7.43-7.52 (m, 3H), 7.65 (dd, J =8 and 2 Hz, 1H), 7.91-7.98 (m, 1H), 8.45 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 432 (100), 404 (15), 209 (23), 180 (25); HRMS. Calc'd for M+H: 432.2512. Found: 432.2571. Example 14 1-isopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-isopentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-isopentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.89 (t, J =7 Hz, 3H), 0.92 (d, J =7 Hz, 6H), 1.26-1.40 (m, 2H), 1.46-1.66 (m, 6H), 2.35 (td, J =8 and 1 Hz, 2H), 3.55 (t, J =8 Hz, 2H), 5.82 (t, J =1 Hz, 1H), 10.41 (br s, 1H); MS (FAB) m/e (rel intensity) 211 (100), 141 (13), 111 (14); HRMS. Calc'd for M+H: 211.1810. Found: 211.1800. Step 2 : Preparation of 1-isopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-isopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 168.5-170.0° C; NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 0.95 (d, J =6 Hz, 6H), 1.27-1.67 (m, 7H), 2.38 (t, J =8 Hz, 2H), 3.63 (t, J =8 Hz, 2H), 4.95 (s, 2H), 5.96 (s, 1H), 7.32 (d, J =8 Hz, 1H), 7.44-7.56 (m, 3H), 7.69 (dd, J =8 and 1 Hz, 1H), 8.00 (td, J =3 and 1 Hz, 1H), 8.47 (br s, 1H); MS (FAB) m/e (rel intensity) 446 (100), 418 (21), 403 (8), 237 (12), 209 (30), 194 (13), 180 (28); HRMS. Calc'd for M+H: 446.2662. Found: 446.2668. Example 15 1-pentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-pentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-pentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.87 (t, J =7 Hz, 3H), 0.89 (t, J =7 Hz, 3H), 1.21-1.39 (m, 6H), 1.42-1.69 (m, 4H), 2.34 (td, J =8 and 1 Hz, 2H), 3.52 (t, J =8 Hz, 2H), 5.82 (t, J =1 Hz, 1H), 10.45 (br s, 1H); MS (FAB) m/e (rel intensity) 211 (100), 141 (19); HRMS. Calc'd for M+H: 211.1810. Found: 211.1792. Step 2 : Preparation of 1-pentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-pentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 162-164° C; NMR (CDCl 3 ) δ 0.87 (t, J =7 Hz, 3H), 0.89 (t, J =7 Hz, 3H), 1.23-1.41 (m, 6H), 1.42-1.54 (m, 2H), 1.61-1.73 (m, 2H), 2.39 (t, J =8 Hz, 2H), 3.61 (t, J =8 Hz, 2H), 4.96 (s, 2H), 5.96 (s, 1H), 7.39 (d, J =8 Hz, 1H), 7.48-7.58 (m, 3H), 7.76 (dd, J =8 and 1 Hz, 1H), 8.02-8.09 (m, 1H), 8.51 (d, J =1 Hz, 1H); MS (FAB) m/e (rel intensity) 446 (58), 418 (22), 237 (18), 209 (100), 194 (29), 180 (55); HRMS. Calc'd for M+H: 446.2668. Found: 446.2683. Example 16 1-isopropyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-isopropyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-isopropyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.88 (t, J =8 Hz, 3H), 1.24 (d, J =7 Hz, 6H), 1.28-1.39 (m, 2H), 1.43-1.59 (m, 2H), 2.34 (td, J =8 and 1 Hz, 2H), 4.34 (m, J =7 Hz, 1H), 5.87 (t, J =1 Hz, 1H), 10.39 (br s, 1H); MS (FAB) m/e (rel intensity) 183 (100), 141 (48), 139 (37); HRMS. Calc'd for M+H: 183.1497. Found: 183.1472. Step 2 : Preparation of 1-isopropyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-isopropyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.87 (t, J =7 Hz, 3H), 1.30 (d, J =7 Hz, 6H), 1.22-1.41 (m, 2H), 1.41-1.53 (m, 2H), 2.28 (t, J =8 Hz, 2H), 4.42 (m, J =7 Hz, 1H), 4.96 (s, 1H), 6.00 (s, 1H), 7.27 (d, J =8 Hz, 1H), 7.43-7.52 (m, 3H), 7.65 (dd, J =8 and 2 Hz, 1H), 7.89-7.96 (m, 1H), 8.44 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 418 (100), 390 (35), 375 (10), 361 (10), 237 (15), 209 (100), 193 (30), 180 (90); HRMS. Calc'd for M+H: 418.2355. Found: 418.2381. Example 17 1-tertbutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-tertbutyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-tertbutyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.90 (t, J =8 Hz, 3H), 1.27-1.38 (m, 2H), 1.45-1.59 (m, 2H), 1.51 (s, 9H), 2.32 (td, J =8 and 1 Hz, 2H), 5.94 (t, J =1 Hz, 1H), 9.86 (br s, 1H); MS (FAB) m/e (rel intensity) 197 (73), 141 (100); HRMS. Calc'd for M+H: 197.1654. Found: 197.1670. Step 2: Preparation of 1-tertbutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV, the imidazol-2-one from Step 1 was converted to 1-tertbutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tertazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.22-1.59 (m, 4H), 1.55 (s, 9H), 2.27 (t, J =8 Hz, 2H), 4.90 (s, 2H), 6.06 (s, 1H), 7.37 (d, J =8 Hz, 1H), 7.48-7.58 (m, 3H), 7.71 (dd, J =8 and 2 Hz, 1H), 7.99-8.06 (m, 1H), 8.48 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 432 (100), 404 (20), 389 (5), 375 (15), 348 (10), 237 (15), 209 (95), 194 (25), 180 (55); HRMS. Calc'd for M+H: 432.2512. Found: 432.2578. Example 18 1-neopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-neopentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-neopentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.87 (t, J =8 Hz, 3H), 0.92 (s, 9H), 1.23-1.37 (m, 2H), 1.43-1.55 (m, 2H), 2.31 (td, J =8 and 1 Hz, 2H), 3.31 (s, 2H), 5.80 (t, J =1 Hz, 1H), 10.62 (br s, 1H); MS (FAB) m/e (rel intensity) 211 (100), 141 (22); HRMS. Calc'd for M+H: 211.1810. Found: 211.1745. Step 2 : Preparation of 1-neopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-neopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 194.5-195.0° C; NMR (CDCl 3 ) δ 0.89 (t, J =7 Hz, 3H), 0.97 (s, 9H), 1.29-1.55 (m, 4H), 2.31 (t, J =8 Hz, 2H), 3.41 (s, 2H), 4.98 (s, 2H), 5.96 (s, 1H), 7.43 (d, J =8 Hz, 1H), 7.50-7.59 (m, 3H), 7.82 (dd, J =8 and 2 Hz, 1H), 8.06-8.13 (m, 1H), 8.54 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 446 (100), 418 (17), 403 (6), 237 (11), 209 (27), 194 (11), 180 (27); HRMS. Calc'd for M+H: 446.2668. Found: 446.2647. Example 19 1-(3,3-dimethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-(3,3-dimethylbutyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(3,3-dimethylbutyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.92 (t, J =8 Hz, 3H), 0.96 (s, 9H), 1.28-1.42 (m, 2H), 1.48-1,59 (m, 4H), 2.38 (td, J =8 and 1 Hz, 2H), 3.54-3.62 (m, 2H), 5.58 (t, J =1 Hz, 1H), 9.70 (br s, 1H); MS (FAB) m/e (rel intensity) 225 (100), 141 (13); HRMS. Calc'd for M+H: 225.1967. Found: 225.1897. Step 2 : Preparation of 1-(3,3-dimethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(3,3-dimethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.89 (t, J =8 Hz, 3H), 0.97 (s, 9H), 1.29-1.54 (m, 4H), 1.55-1.63 (m, 2H), 2.30 (t, J =8 Hz, 2H), 3.60-3.68 (m, 2H), 4.95 (s, 2H), 5.97 (s, 1H), 7.38 (d, J =8 Hz, 1H), 7.48-7.59 (m, 3H), 7.75 (dd, J =8 and 2 Hz, 1H), 8.02-8.09 (m, 1H), 8.51 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 460 (47), 432 (23), 237 (18), 209 (100), 194 (32), 180 (74); HRMS. Calc'd for M+H: 460.2825. Found: 460.2821. Example 20 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.80-0.91 (m, 9H), 1.18-1.37 (m, 6H), 1.41-1.64 (m, 3H), 2.32 (td, J =8 and 1 Hz, 2H), 3.41 (d, J =8 Hz, 2H), 5.72 (t, J =1 Hz, 1H), 10.60 (br s, 1H); MS (FAB) m/e (rel intensity) 225 (100), 141 (22); HRMS. Calc'd for M+H: 225.1967. Found: 225.1971. Step 2 : Preparation of 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 174-176° C (dec); NMR (CDCl 3 ) δ 0.85-0.96 (m, 9H), 1.27-1.40 (m, 6H), 1.41-1.55 (m, 2H), 1.59-1.70 (m, 1H), 2.30 (t, J =8 Hz, 2H), 3.53 (d, J =8 Hz, 2H), 4.97 (s, 2H), 5.94 (s, 1H), 7.39 (d, J =8 Hz, 1H), 7.48-7.58 (m, 3H), 7.75 (dd, J =8 and 2 Hz, 1H), 8.03-8.09 (m, 1H), 8.51 (d, J=2 Hz, lH); MS (FAB) m/e (rel intensity) 460 (73), 432 (25), 237 (23), 209 (100), 194 (29), 180 (61); HRMS. Calc'd for M+H: 460.2825. Found: 460.2862. Example 21 1-cyclohexyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-cyclohexyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemnes III and IV, 1-cyclohexyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.05-1.24 (m, 2H), 1.26-1.46 (m, 4H), 1.47-1.58 (m, 2H), 1.63-1.76 (m, 2H), 1.78-1.96 (m, 4H), 2.36 (td, J =8 and 1 Hz, 2H), 3.87-4.00 (m, 1H), 5.89 (t, J =1 Hz, 1H), 9.82 (br s, 1H); MS (FAB) m/e (rel intensity) 223 (100), 141 (53); HRMS. Calc'd for M+H: 223.1810. Found: 223.1738. Step 2 : Preparation of 1-cyclohexyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-cyclohexyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 202-203° C (dec); NMR (CDCl 3 ) δ 0.89 (t, J =8 Hz, 3H), 1.08-1.24 (m, 2H), 1.26-1.54 (m, 7H), 1.66-1.76 (m, 1H), 1.77-2.00 (m, 4H), 2.28 (t, J =8 Hz, 2H), 3.95-4.07 (m, 1H), 4.97 (s, 2H), 6.00 (s, 1H), 7.32 (d, J =8 Hz, 1H), 7.45-7.55 (m, 3H), 7.69 (dd, J =8 and 2 Hz, 1H), 7.96-8.04 (m, 1H), 8.47 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 458 (56), 430 (19), 237 (19), 208 (100), 194 (36), 180 (76); HRMS. Calc'd for M+H: 458.2668. Found: 458.2732. Example 22 1-(2-cyclopropylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2-cyclopropylethyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV or XXIII, 1-(2-cyclopropylethyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.00-0.06 (m, 2H), 0.38-0.46 (m, 2H), 0.59-0.73 (m, 1H), 0.89 (t, J =8 Hz, 3H), 1.16-1.40 (m, 4H), 1.44-1.57 (m, 4H), 2.34 (td, J =8 and 1 Hz, 2H), 3.62 (t, J =7 Hz, 2H), 5.84 (t, J =1 Hz, 1H), 10.38 (br s, 1H); MS (FAB) m/e (rel intensity) 209 (100), 153 (43), 141 (16); HEMS. Calc's for M+H: 209.1654. Found: 209.1695. Step 2 : Preparation of 1-(2-cyclopropylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-cyclopropylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 182-183° C; NMR (CDCl 3 ) δ 0.04-0.11 (m, 2H), 0.43-0.51 (m, 2H), 0.60-0.76 (m, 1H), 0.91 (t, J =7 Hz, 3H), 1.30-1.44 (m, 2H), 1.45-1.64 (m, 4H), 2.36 (t, J =7 Hz, 2H), 3.72 (t, J =7 Hz, 2H), 5.04 (s, 2H), 6.01 (s, 1H), 7.57-7.68 (m, 4H), 8.11 (d, J =7 Hz, 1H), 8.15-8.20 (m, 1H), 8.64 (s, 1H); MS (FAB) m/e (rel intensity) 237 (24), 209 (53), 192 (18), 180 (43); HRMS. Calc'd for M+H: 444.2512. Found: 444.2509. Example 23 1-cyclopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-cyclopentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-cyclopentyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.91 (t, J =8 Hz, 3H), 1.29-1.42 (m, 2H), 1.48-1.85 (m, 10H), 1.98-2.12 (m, 2H), 2.47 (td, J =8 and 1 Hz, 2H), 4.44-4.57 (m, 1H), 5.88 (t, J =1 Hz, 1H), 10.22 (br s, 1H); MS (FAB) m/e (rel intensity) 209 (100), 141 (43); HRMS. Calc'd for M+H: 209.1654. Found: 209.1656. Step 2: Preparation of 1-cyclopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-cyclopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.30-1.40 (m, 2H), 1.41-1.52 (m, 2H), 1.56-1.86 (m, 6H), 2.02-2.14 (m, 2H), 2.27 (t, J =7 Hz, 2H), 4.55 (m, J =7 Hz, 1H), 4.97 (s, 2H), 5.98 (s, 1H), 7.27 (d, J =8 Hz, 1H), 7.44-7.54 (m, 3H), 7.62 (dd, J =8 and 2 Hz, 1H), 7.98-8.05 (m, 1H), 8.48 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 444 (100), 416 (12), 401 (6), 387 (4), 233 (13), 209 (22), 194 (12), 180 (25); HRMS. Calc'd for M+H: 444.2512. Found: 444.2518. Example 24 1-cyclopentylmethyl-4-butyl-1,3-dihydro-3[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-cyclopentylmethyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-cyclopentylmethyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.89 (t, J =8 Hz, 3H), 1.16-1.39 (m, 4H), 1.44-1.77 (m, 8H), 2.21 (m, J =8 Hz, 1H), 2.45 (t, J =8 Hz, 2H), 3.46 (d, J =8 Hz, 2H), 5.81-5.85 (m, 1H), 10.33 (br s, 1H); MS (FAB) m/e (rel intensity) 223 (100), 141 (30); HRMS. Calc'd for M+H: 223.1810. Found: 223.1767. Step 2 : Preparation of 1-cyclopentylmethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-cyclopentylmethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 204° C (dec); NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.19-1.70 (m, 12H), 2.19-2.34 (m, 3H), 3.55 (d, J =8 Hz, 2H), 4.98 (s, 2H), 5.98 (t, J =1 Hz, 1H), 7.44 (d, J =8 Hz, 1H), 7.50-7.61 (m, 3H), 7.81 (dd, J =8 and 2 Hz, 1H), 8.07-8.13 (m, 1H), 8.53 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 458 (65), 430 (22), 237 (24), 209 (100), 194 (30), 180 (65); HRMS. Calc'd for M+H: 458.2668. Found: 458.2699. Example 25 1-[2-(2-thienyl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-[2-(2-thienyl)ethyl]-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-[2-(2-thienyl)ethyl]-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.90 (t, J =7 Hz, 3H), 1.26-1.40 (m, 2H), 1.44-1.56 (m, 2H), 2.32 (t, J =7 Hz, 2H), 3.16 (t, J =7 Hz, 2H), 3.82 (t, J =7 Hz, 2H), 5.69-5.75 (m, 1H), 6.80-6.83 (m, 1H), 6.90-6.95 (m, 1H), 7.12-7.17 (m, 1H), 10.02 (br s, 1H); MS (FAB) m/e (rel intensity) 251 (90), 111 (100); HRMS. Calc'd for M+H: 251.1218. Found: 251.1209. Step 2 : Preparation of 1-[2-(2-thienyl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-[2-(2-thienyl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 137-138° C; NMR (CDCl 3 ) δ 0.86 (t, J =7 Hz, 3H), 1.23-1.36 (m, 2H), 1.37-1.51 (m, 2H), 2.26 (td, J =8 and 1 Hz, 2H), 3.23 (t, J =8 Hz, 2H), 3.93 (t, J =8 Hz, 2H), 4.93 (s, 2H), 5.84 (t, J =1 Hz, 1H), 6.84 (d, J =8 Hz, 1H), 6.91-6.96 (m, 1H), 7.17 (dd, J =8 and 2 Hz, 1H), 7.49 (d, J =8 Hz, 1H), 7.53-7.64 (m, 3H), 7.69 (dd, J =8 and 2 Hz, 1H), 8.25-8.30 (m, 1H), 8.57 (d, J =2 Hz, 1H); HRMS. Calc'd for M+H: 486.2076. Found: 486.2092. Example 26 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-(2-phenylethyl)-4-butyl-1,3-dihydro-2-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-phenylethyl)-4-butyl-1,3-dihydro-2-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.90 (t, J =7 Hz, 3H), 1.31 (m, J =7 Hz, 2H), 1.49 (m, J =7 Hz, 2H), 2.32 (td, J =7 and 1 Hz, 2H), 2.94 (t, J =7 Hz, 2H), 3.80 (t, J =7 Hz, 2H), 5.66 (t, J =1 Hz, 1H), 7.15- 7.33 (m, 5H), 9.89 (br s, 1H); MS (FAB) m/e (rel intensity) 245 (100), 153 (10), 105 (50). Step 2 : Preparation of 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.85 (t, J =7 Hz, 3H), 1.22-1.47 (m, 4H), 2.24 (t, J =7 Hz, 2H), 2.99 (t, J =7 Hz, 2H), 3.90 (t, J =7 Hz, 2H), 4.93 (s, 2H), 5.80 (s, 1H), 7.16-7.47 (m, 5H), 7.48-7.59 (m, 4H), 8.05-8.12 (m, 1H), 8.47 (s, 1H); MS (FAB) m/e (rel intensity) 480 (100), 452 (20), 437 (5), 237 (18), 209 (8), 180 (81); HRMS. Calc'd for M+H: 480.2512. Found: 480.2561. Example 27 1-(2-cyclopentylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-(2-cyclopentylethyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-cyclopentylethyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.00-1.16 (m, 2H), 1.25-1.39 (m, 2H), 1.41-1.67 (m, 8H), 1.68-1.84 (m, 3H), 2.33 (t, J =8 Hz, 2H), 3.54 (t, J =8 Hz, 2H), 5.79-5.83 (m, 1H), 10.58 (br s, 1H); MS (FAB) m/e (rel intensity) 273 (100), 141 (8); HRMS. Calc'd for M+H: 237.1967. Found: 237.1898. Step 2 : Preparation of 1-(2-cyclopentylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Scheme XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-cyclopentylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.06-1.20 (m, 2H), 1.23-1.87 (m, 13H), 2.23 (t, J =7 Hz, 2H), 3.63 (t, J =7 Hz, 2H), 4.95 (s, 2H), 5.96 (s, 1H), 7.28 (d, J =8 Hz, 1H), 7.44-7.54 (m, 3H), 7.62 (dd, J =8 and 2 Hz, 1H), 7.97-8.04 (m, 1H), 8.48 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 472 (100), 444 (27), 429 (5), 416 (3), 237 (19), 209 (65), 195 (19); HRMS. Calc'd for M+H: 472.2825. Found: 472.2881. Example 28 1-[2-(cyclopenten-1-yl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-[2-(cyclopenten-1-yl)ethyl]-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-[2-(cyclopenten-1-yl)ethyl]-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.90 (t, J =7 Hz, 3H), 1.22-1.41 (m, 2H), 1.44-1.58 (m, 2H), 1.77-1.91 (m, 2H), 2.18-2.46 (m, 8H), 3.68 (t, J =8 Hz, 2H), 5.36-5.43 (m, 1H), 5.82-5.87 (m, 1H), 9.23 (br s, 1H); MS (FAB) m/e (rel intensity) 235 (90), 141 (100); HRMS. Calc'd for M+H: 235.1810. Found: 235.1804. Step 2 : Preparation of 1-[2-(cyclopenten-1-yl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-[2-(cyclopenten-1-yl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 1.21-1.39 (m, 2H), 1.39-1.53 (m, 2H), 1.86 (m, J =7 Hz, 2H), 2.28 (t, J =7 Hz, 6H), 2.45 (t, J =7 Hz, 2H), 3.76 (t, J =7 Hz, 2H), 4.95 (s, 2H), 5.41 (s, 1H), 5.96 (s, 1H), 7.45 (d, J =8 Hz, 1H), 7.49-7.63 (m, 3H), 7.76 (d, J =8 Hz, 1H), 8.12-8.20 (m, 1H), 8.55 (s, 1H); MS (FAB) m/e (rel intensity) 470 (30), 442 (10); HRMS. Calc'd for M+H: 470.2668. Found: 470.2599. Example 29 1-(2-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2-adamantyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-adamentyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.27-1.42 (m, 2H), 1.47-1.59 (m, 2H), 1.63 (br s, 1H), 1.67 (br s, 1H), 1.78 (br s, 2H), 1.84-2.02 (m, 8H), 2.37 (t, J =8 Hz, 2H), 2.42 (br s, 2H), 4.09 (s, 1H), 6.18-6.22 (m, 1H), 9.53 (br s, 1H); MS (FAB) m/e (rel intensity) 275 (100), 141 (30), 135 (30); HRMS. Calc'd for M+H: 275.2123. Found: 275.2065. Step 2 : Preparation of 1-(2-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-dimidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.32-1.45 (m, 2H), 1.47-1.58 (m, 2H), 1.62-2.00 (m, 12H), 2.34 (t, J =8 Hz, 2H), 2.47 (br s, 2H), 4.15 (s, 1H), 4.96 (s, 2H), 6.35 (s, 1H), 7.51-7.58 (m, 2H), 7.61-7.68 (m, 2H), 7.93 (dd, J =8 and 2 Hz, 1H), 8.13 (dd, J =6 and 4 Hz, 1H), 8.56 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 510 (100), 482 (10), 467 (5), 237 (10), 209 (10); HRMS. Calc'd for M+H: 510.2981. Found: 510.3038. Example 30 1-(1-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(1-adamantyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(1-adamentyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.92 (t, J =8 Hz, 3H), 1.29-1.43 (m, 2H), 1.47-1.59 (m, 2H), 1.72 (br s, 1H), 2.16 (br s, 3H), 2.21 (br s, 6H), 2.36 (t, J =8 Hz, 2H), 6.01 (br s, 1H), 9.43 (br s, 1H); MS (FAB) m/e (rel Intensity) 275 (100), 141 (6), 135 (83); HRMS. Calc'd for M+H: 275.2123. Found: 275.2057. Step 2 : Preparation of 1-(1-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(1-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.89 (t, J =7 Hz, 3H), 1.30-1.42 (m, 2H), 1.42-1.54 (m, 2H), 1.64-1.71 (m, 6H), 2.07-2.34 (m, 11H), 4.90 (s, 2H), 6.08 (s, 1H), 7.47-7.66 (m, 4H), 7.78 (dd, J =8 and 2 Hz, 1H), 8.20-8.25 (m, 1H), 8.57 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 510 (60), 482 (5), 467 (5), 237 (5); HRMS. Calc'd for M+H: 510.2981. Found: 510.3033. Example 31 1-phenyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-phenyl-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-phenyl-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.93 (t, J=7 Hz, 3H), 1.39 (m, J =7 Hz, 2H), 1.59 (m, J =7 Hz, 2H), 2.42 (td, J =8 and 1 Hz, 2H), 6.26 (t, J =1 Hz, 1H), 7.21 (t, J =7 Hz, 1H), 7.41 (t, J =8 Hz, 2H), 7.57-7.62 (m, 2H), 10.28 (br s, 1H); MS (FAB) m/e (rel intensity) 217 (100), 201 (2), 187 (3), 173 (11); HRMS. Calc'd for M+H: 217.1341. Found: 217.1309. Step 2 : Preparation of 1-phenyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-phenyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.40 (m, J =7 Hz, 2H), 1.55 (m, J =7 Hz, 2H), 2.39 (t, J =7 Hz, 2H), 5.05 (s, 2H), 6.38 (s, 1H), 7.20-7.26 (m, 1H), 7.34-7.56 (m, 6H), 7.59-7.66 (m, 2H), 7.85 (dd, J =8 and 2 Hz, 1H), 7.97-8.03 (m, 1H), 8.58 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 452 (51), 424 (23), 409 (7), 237 (13), 217 (13), 209 (100), 208 (67), 194 (38), 193 (38); HRMS. Calc'd for M+H: 452.2199. Found: 452.2248. Example 32 1-(2-chlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2-chlorophenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-chlorophenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.90 (t, J =7 Hz, 3H), 1.36 (m, J =7 Hz, 2H), 1.54 (m, J =7 Hz, 2H), 2.37 (t, J =7 Hz, 2H), 6.06 (br s, 1H), 7.23-7.38 (m, 2H), 7.41-7.53 (m, 2H), 10.29 (br s, 1H); MS (FAB) m/e (rel intensity) 252 (36), 250 (100). Step 2 : Preparation of 1-(2-chlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-chlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 81-83° C; NMR (CDCl 3 ) δ 0.90 (t, J =7 Hz, 3H), 1.39 (m, J =7 Hz, 2H), 1.54 (m, J =7 Hz, 2H), 2.37 (td, J =8 and 1 Hz, 2H), 5.03 (s, 2H), 6.19 (t, J =1 Hz, 1H), 7.31-7.37 (m, 2H), 7.46-7.63 (m, 6H), 7.88 (dd, J =8 and 2 Hz, 1H), 8.15-8.21 (m, 1H), 8.65 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 488 (15), 486 (37), 460 (5), 458 (8); HRMS. Calc'd for M+H: 486.1809. Found: 486.1781. Example 33 1-(2-methylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2-methylphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-methylphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.92 (t, J =7 Hz, 3H), 1.37 (m, J =7 Hz, 2H), 1.55 (m, J =7 Hz, 2H), 2.28 (s, 3H), 2.39 (td, J =7 Hz, 2H), 5.96-5.99 (m, 1H), 7.21-7.31 (m, 4H), 9.88 (br s, 1H); MS (FAB) m/e (rel intensity) 231 (100), 201 (2), 175 (2), 155 (3), 127 (4), 106 (3); HRMS. Calc'd for M+H: 231.1497. Found: 231.1448. Step 2 : Preparation of 1-(2-methylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-methylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.89 (t, J =8 Hz, 3H), 1.31-1.45 (m, 2H), 1.46-1.59 (m, 2H), 2.26 (s, 3H), 2.37 (td, J =8 and 1 Hz, 2H), 5.05 (s, 2H), 6.10 (t, J =1 Hz, 1H), 7.22-7.31 (m, 4H), 7.37 (d, J =8 Hz, 1H), 7.48-7.59 (m, 3H), 7.81 (dd, J =8 and 2 Hz, 1H), 7.98-8.05 (m, 1H), 8.57 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 466 (64), 438 (23), 237 (25), 231 (33), 209 (100), 194 (37), 193 (32), 180 (83); HRMS. Calc'd for M+H: 466.2355. Found: 466.2397. Example 34 1-(2-methoxyphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-(2-methoxyphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-methoxyphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.37 (m, J =7 Hz, 2H), 1.56 (m, J =7 Hz, 2H), 2.40 (td, J =8 and 1 Hz, 2H), 3.83 (s, 3H), 6.08-6.12 (m, 1H), 6.96-7.04 (m, 2H), 7.29 (td, J =8 and 2 Hz, 1H), 7.43 (dd, J =8 and 2 Hz, 1H), 9.94 (s, 1H); MS (FAB) m/e (rel intensity) 247 (100), 217 (3), 203 (7); HRMS. Calc'd for M+H: 247.1447. Found: 247.1470. Step 2 : Preparation of 1-(2-methoxyphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-methoxyphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.40 (m, J =7 Hz, 2H), 1.53 (m, J =7 Hz, 2H), 2.40 (t, J =7 Hz, 2H), 3.83 (s, 3H), 5.06 (s, 2H), 6.20 (s, 1H), 6.96-7.03 (m, 2H), 7.27-7.34 (m, 3H), 7.42 (dd, J =8 and 2 Hz, 1H), 7.53-7.65 (m, 4H), 8.09-8.17 (m, 2H), 8.66 (s, 1H); MS (FAB) m/e (rel intensity) 482 (67), 454 (20), 439 (5), 247 (40), 237 (22), 209 (100), 208 (66), 194 (38), 193 (31); HRMS. Calc'd for M+H: 482.2304. Found: 482.2324. Example 35 1-(2-isopropylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2-isopropylphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2-isopropylphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.89 (t, J =7 Hz, 3H), 1.21 (d, J =7 Hz, 6H), 1.30-1.44 (m, 2H), 1.48-1.60 (m, 2H), 2.38 (t, J =7 Hz, 2H), 3.05 (m, J =7 Hz, 1H), 5.93-5.96 (m, 1H), 7.17-7.42 (m, 4H), 10.65 (br s, 1H); MS (FAB) m/e (rel intensity) 259 (100); HEMS. Calc'd for M+H: 259.1810. Found: 259.1799. Step 2: Preparation of 1-(2-isopropylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl ] -2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or XXIII, the imidazol-2-one from Step 1 was converted to 1-(2-isopropylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 6 0.89 (t, J =7 Hz, 3H), 1.21 (d, J =7 Hz, 6H), 1.37 (m, J =7 Hz, 2H), 1.52 (m, J =7 Hz, 2H), 2.36 (t, J =7 Hz, 2H), 2.98 (m, J =7 Hz, 1H), 5.07 (s, 2H), 6.07 (s, 1H), 7.09-7.25 (m, 2H), 7.30-7.43 (m, 3H), 7.46-7.55 (m, 3H), 7.81 (dd, J =8 and 1 Hz, 1H), 7.92-7.99 (m, 1H), 8.53 (d, J =1 Hz, 1H); MS (FAB) m/e (rel intensity) 494 (75), 466 (26), 451 (4), 259 (14), 237 (37), 209 (100), 208 (61), 194 (37), 193 (32); HRMS. Calc'd for M+H: 494.2668. Found: 494.2651. Example 36 1-(2,6-difluorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2,6-difluorophenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2,6-difluorophenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.93 (t, J =7 Hz, 3H), 1.31-1.46 (m, 2H), 1.50-1.62 (m, 2H), 2.41 (td, J =8 and 1 Hz, 2H), 6.05 (t, J =1 Hz, 1H), 6.98-7.08 (m, 2H), 7.27-7.39 (m, 1H), 9.18 (br s, 1H). Step 2 : Preparation of 1-(2,6-difluorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or Scheme XXIII, the imidazol-2-one from Step 1 was converted to 1-(2,6-difluorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 164.5-165.5° C (dec); NMR (CDCl 3 ) δ 0.90 (t, J =8 Hz, 3H), 1.32-1.46 (m, 2H), 1.48-1.60 (m, 2H), 2.37 (td, J =8 and 1 Hz, 2H) 5.04 (s, 2H), 6.14 (t, J =1 Hz, 1H), 7.05 (t, J =8 Hz, 2H), 7.29-7.38 (m, 1H), 7.42 (d, J =8 Hz, 1H), 7.48-7.58 (m, 3H), 7.81 (dd, J =8 and 2 Hz, 1H), 8.04-8.11 (m, 1H), 8.60 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 488 (83), 460 (26), 253 (10), 237 (25), 209 (100), 194 (37), 193 (35), 180 (80); HRMS. Calc'd for M+H: 488.2010. Found: 488.1951. Example 37 1-(2,6-dichlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1 : Preparation of 1-(2,6-dichlorophenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2,6-dichlorophenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.93 (t, J =7 Hz, 3H), 1.32-1.46 (m, 2H), 1.51-1.62 (m, 2H), 2.43 (td, J =8 and 1 Hz, 2H), 5.94 (t, J =1 Hz, 1H), 7.27-7.32 (m, 1H), 7.40-7.46 (m, 2H), 9.33 (br s, 1H). Step 2 : Preparation of 1-(2,6-dichlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Scheme XII and XIV or Scheme XXIII, the imidazol-2-one from Step 1 was converted to 1-(2,6-dichlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 212.0-212.5° C; NMR (CDCl 3 ) δ 0.88 (t, J =8 Hz, 3H), 1.30-1.44 (m, 2H), 1.47-1.59 (m, 2H), 2.34 (td, J =8 and 1 Hz, 2H), 5.10 (s, 2H), 6.04 (t, J =1 Hz, 1H), 7.28-7.35 (m, 2H), 7.42-7.55 (m, 5H), 7.76 (dd, J =8 and 2 Hz, 1H), 7.97-8.04 (m, 1H), 8.53 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 522 (48), 520 (85), 494 (8), 492 (12), 287 (4), 285 (8), 237 (51), 209 (93), 194 (35), 193 (31), 180 (95); HRMS. Calc'd for M+H: 520.1419. Found: 420.1443. Example 38 1-(2,6-dimethylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one Step 1: Preparation of 1-(2,6-dimethylphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one. Following General Synthetic Schemes III and IV, 1-(2,6-dimethylphenyl)-4-butyl-1,3-dihydro-2H-imidazol-2-one was prepared: NMR (CDCl 3 ) δ 0.91 (t, J =7 Hz, 3H), 1.29-1.32 (m, 2H), 1.49-1.61 (m, 2H), 2.18 (s, 6H), 2.41 (t, J =7 Hz, 2H), 5.83-5.86 (m, 1H), 7.07-7.21 (m, 3H), 9.66 (br s, 1H); MS (FAB) m/e (rel intensity) 245 (100), 215 (4), 118 (9); HRMS. Calc'd for M+H: 245.1654. Found: 245.1668. Step 2 : Preparation of 1-(2,6-dimethylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Following General Synthetic Schemes XII and XIV or Scheme XXIII, the imidazol-2-one from Step 1 was converted to 1-(2,6-dimethylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.91 (t, J =8 Hz, 3H), 1.33-1.47 (m, 2H), 1.49-1.61 (m, 2H), 2.09 (s, 6H), 2.42 (td, J =8 and 1 Hz, 1H), 5.09 (s, 2H), 6.04 (t, J =1 Hz, 1H), 7.06-7.11 (m, 2H), 7.14-7.21 (m, 1H), 7.52-7.61 (m, 2H), 7.62-7.69 (m, 2H), 7.96-8.07 (m, 2H), 8.57 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 480 (53), 452 (22), 245 (23), 237 (25), 209 (98), 194 (45), 193 (42), 180 (100); HEMS. Calc'd for M+H: 480.2512. Found: 480.2551. Example 39 1,4-dibutyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one Following General Synthetic Schemes XII and XIII, 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one (prepared in Step 2A of Example 1) was converted to 1,4-dibutyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one as a colorless solid: NMR (CDCl 3 ) δ 0.85 (t, J =7 Hz, 3H), 0.88 (t, J =7 Hz, 3H), 1.11-1.35 (m, 4H), 1.42 (m, J =7 Hz, 2H), 1.57 (m, J = 7 Hz, 2H), 2.27 (t, J =7 Hz, 2H), 3.57 (t, J =7 Hz, 2H), 4.78 (s, 2H), 5.93 (s, 1H), 6.86 (d, J =8 Hz, 1H), 7.35 (dd, J =8 and 2 Hz, 1H), 7.42 (d, J =8 Hz, 1H), 7.52-7.56 (m, 1H), 7.58-7.62 (m, 1H), 7.89 (d, J =8 Hz, 1H), 8.27 (d, J =2 Hz, 1H); MS (FAB) m/e (rel intensity) 425 (66), 404 (15), 389 (15), 237 (6), 208 (82), 193 (43), 180 (100); HRMS. Calc'd for M+L: 438.2594. Found: 438.2645. Anal. Calc'd for C 24 H 29 N 7 O: C, 66.80; H, 6.77; N, 22.72. Found: C, 67.15; H, 6.83; N, 22.94. Example 40 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one Following General Synthetic Schemes XXVIII, XXIV, and XX, 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one (prepared in Step 2A of Example 1) was converted to 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 178.0-179.5° C; NMR (CDCl 3 ) δ 0.85 (t, J =7 Hz, 3H), 0.88 (t, J =7 Hz, 3H), 1.23-1.49 (m, 6H), 1.50-1.63 (m, 2H), 2.20 (t, J =7 Hz, 2H), 3.50 (t, J =7 Hz, 2H), 4.70 (s, 2H), 5.94 (s, 1H), 7.02 (d, J =8 Hz, 2H), 7.22 (d, J =8 Hz, 2H), 7.56 (dd, J =5 and 3 Hz, 1H), 8.31 (d, J =5 Hz, 1H), 8.77 (d, J =3 Hz, 1H); MS (FAB) m/e (rel intensity) 432 (21), 389 (4), 237 (8), 209 (28), 208 (100), 194 (20), 180 (14), 153 (7); HRMS. Calc'd for M+H: 432.2512. Found: 432.2558. Example 41 1,4-dibutyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one Following General Synthetic Schemes XXVIII, XXV, and XX, 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one (prepared in Step 2A of Example 1) was converted to 1,4-dibutyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 128-130° C; NMR (CDCl 3 ) δ 0.86 (t, J =7 Hz, 3H), 0.89 (t, J =7 Hz, 3H), 1.21-1.36 (m, 4H), 1.36-1.49 (m, 2H), 2.21 (t, J =7 Hz, 2H), 4.74 (s, 2H), 5.96 (s, 1H), 7.04 (d, J =8 Hz, 2H), 7.11 (d, J =8 Hz, 2H), 7.90 (d, J =5 Hz, 1H), 8.64 (s, 1H), 8.66 (d, J =5 Hz, 1H); MS (FAB) m/e (rel Intensity) 432 (20), 389 (10), 208 (100), 197 (30), 193 (30); HRMS. Calc'd for M+H: 432.2512. Found: 432.2508. Example 42 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one Following General Synthetic Schemes XXVIII, XXVI, and XX, 1,4-dibutyl-1,3-dihydro-2H-imidazol-2-one (prepared in Step 2A of Example 1) was converted to 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 176-178° C (dec); NMR (CDCl 3 ) δ 0.86 (t, J =7 Hz, 3H), 0.90 (t, J =7 Hz, 3H), 1.22-1.36 (m, 4H), 1.37-1.49 (m, 2H), 1.53-1.66 (m, 2H), 2.22 (t, J =8Hz, 2H), 3.57 (t, J =8Hz, 2H), 4.72 (s, 2H), 5.96 (s, 1H), 7.01 (d, J =9Hz, 2H), 7.09 (d, J =9Hz, 2H), 7.43 (d, J =5Hz, 1H), 8.71 (d, J =5Hz, 1H), 8.87 (s, 1H); MS (FAB) m/e (rel intensity) 432 (22), 404 (3), 389 (5), 237 (22), 208 (100), 193 (34), 180 (75), 167 (18), 153 (22), 141 (10), 128 (6), 111 (12); HEMS. Calc'd. for M+H: 432.2512. Found: 432.2512. Example 43 1,4-dibutyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one Following General Synthetic Schemes XXVIII, XXVII, and XX, 1, 4-dibutyl-1,3-dihydro-2H-imidazol-2-one (prepared in Step 2A of Example 1) was converted to 1,4-dibutyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one as a colorless solid: mp 178.0-179.5° C; NMR (CDCl 3 ) δ 0.88 (t, J =7 Hz, 3H), 0.93 (t, J =7 Hz, 3H), 1.25-1.54 (m, 6H), 1.59-1.72 (m, 2H), 2.28 (t, J =7 Hz, 2H), 3.64 (t, J =7 Hz, 2H), 4.85 (s, 2H), 5.97 (s, 1H), 7.05 (d, J =9 Hz, 2H), 7.10 (d, J =9 Hz, 2H), 7.55 (dd, J =5 and 3 Hz, 1H), 7.80 (d, J =5 Hz, 1H), 8.68 (d, J =3 Hz, 1H); MS (FAB) m/e (rel intensity) 432 (27), 389 (5), 237 (4), 209 (29), 208 (100), 194 (21), 180 (45), 153 (10); HRMS. Calc'd for M+H: 432.2512. Found: 432.2563. BIOLOGICAL EVALUATION Assay A: Angiotensin II Binding Activity Compounds of the invention were tested for ability to bind to the smooth muscle angiotensin II receptor using a rat uterine membrane preparation. Angiotensin II (AII) was purchased from Peninsula Labs. 125 I-angiotensin II (specific activity of 2200 Ci/mmol) was purchased from Du Pont-New England Nuclear. Other chemicals were obtained from Sigma Chemical Co. This assay was carried out according to the method of Douglas et al [ Endocrinology , 106 , 120-124 (1980)]. Rat uterine membranes were prepared from fresh tissue. All procedures were carried out at 4°C. Uteri were stripped of fat and homogenized in phosphate-buffered saline at pH 7.4 containing 5 mM EDTA. The homogenate was centrifuged at 1500 x g for 20 min., and the supernatant was recentrifuged at 100,000 x g for 60 min. The pellet was resuspended in buffer consisting of 2 mM EDTA and 50 mM Tris-HCl (pH 7.5) to a final protein concentration of 4 mg/ml. Assay tubes were charged with 0.25 ml of a solution containing 5 mM MgCl 2 , 2 mM EDTA, 0.5% bovine serum albumin, 50 mM Tris-HCl, pH 7.5 and 125 I-AII (approximately 10 5 cpm) in the absence or in the presence of unlabelled ligand. The reaction was initiated by the addition of membrane protein and the mixture was incubated at 25°C for 60 min. The incubation was terminated with ice-cold 50 mM Tris-HCl (pH 7.5) and the mixture was filtered to separate membrane-bound labelled peptide from the free ligand. The incubation tube and filter were washed with ice-cold buffer. Filters were assayed for radioactivity in a Micromedic gamma counter. Nonspecific binding was defined as binding in the presence of 10 µM of unlabelled AII. Specific binding was calculated as total binding minus nonspecific binding. The receptor binding affinity of an AII antagonist compound was indicated by the concentration (IC 50 ) of the tested AII antagonist which gives 50% displacement of the total specifically bound 125 I-AII from the high affinity AII receptor. Binding data were analyzed by a nonlinear least-squares curve fitting program. Results are reported in Table I. Assay B: In Vitro Vascular Smooth Muscle-Response for AII The compounds of the invention were tested for antagonist activity in rabbit aortic rings. Male New Zealand white rabbits (2-2.5 kg) were sacrificed using an overdose of pentobarbital and exsanguinated via the carotid arteries. The thoracic aorta was removed, cleaned of adherent fat and connective tissue and then cut into 3-mm ring segments. The endothelium was removed from the rings by gently sliding a rolled-up piece of filter paper into the vessel lumen. The rings were then mounted in a water-jacketed tissue bath, maintained at 37°C, between moveable and fixed ends of a stainless steel wire with the moveable end attached to an FT03 Grass transducer coupled to a Model 7D Grass Polygraph for recording isometric force responses. The bath was filled with 20 ml of oxygenated (95% oxygen/5% carbon dioxide) Krebs solution of the following composition (mM): 130 NaCl, 15 NaHCO 3 , 15 KCl, 1.2 NaH 2 PO 4 , 1.2 MgSO 4 , 2.5 CaCl 2 , and 11.4 glucose. The preparations were equilibrated for one hour before approximately one gram of passive tension was placed on the rings. Angiotensin II concentration-response curves were then recorded (3 X 10 -10 to 1 X 10 -5 M). Each concentration of AII was allowed to elicit its maximal contraction, and then AII was washed out repeatedly for 30 minutes before rechallenging with a higher concentration of AII. Aorta rings were exposed to the test antagonist at 10 -5 M for 5 minutes before challenging with AII. Adjacent segments of the same aorta ring were used for all concentration-response curves in the presence or absence of the test antagonist. The effectiveness of the test compound was expressed in terms of pA 2 values and were calculated according to H.O. Schild [ Br. J. Pharmacol. Chemother. , 2 ,189-206 (1947)]. The pA 2 value is the concentration of the antagonist which increases the EC 50 value for AII by a factor of two. Each test antagonist was evaluated in aorta rings from two rabbits. Results are reported in Table I. Assay C: In Vivo Intragastric Pressor Assay Response for All Antagonists Male Sprague-Dawley rats weighing 225-300 grams were anesthetized with methohexital (30 mg/kg, i.p.) and catheters were implanted into the femoral artery and vein. The catheters were tunneled subcutaneously to exit dorsally, posterior to the head and between the scapulae. The catheters were filled with heparin (1000 units/ml of saline). The rats were returned to their cage and allowed regular rat chow and water ad libitum . After full recovery from surgery (3-4 days), rats were placed in Lucite holders and the arterial line was connected to a pressure transducer. Arterial pressure was recorded on a Gould polygraph (mmHg). Angiotensin II was administered as a 30 ng/kg bolus via the venous catheter delivered in a 50 µl volume with a 0.2 ml saline flush. The pressor response in mm Hg was measured by the difference from pre-injection arterial pressure to the maximum pressure achieved. The AII injection was repeated every 10 minutes until three consecutive injections yielded responses within 4 mmHg of each other. These three responses were then averaged and represented the control response to AII. The test compound was suspended in 0.5% methylcellulose in water and was administered by gavage. The volume administered was 2 ml/kg body weight. The standard dose was 3 mg/kg. Angiotensin II bolus injections were given at 30, 45, 60, 75, 120, 150, and 180 minutes after gavage. The pressor response to AII was measured at each time point. The rats were then returned to their cage for future testing. A minimum of 3 days was allowed between tests. Percent inhibition was calculated for each time point following gavage by the following formula: [(Control Response - Response at time point)/Control Response] X 100. Results are shown in Table I. In Vitro and In Vivo Angiotensin II Activity of Compounds of the Invention Test Compound Example # Assay A IC 50 (nM) Assay B pA 2 Assay C Dose: 3 mg/kg (i.g.) Inhibition (%) Duration (min.) 1 6.5 8.82/8.53 50 > 180 2 38 8.13/7.40 25 180 3 770 7.46/6.95 NA 4 140 7.72/7.09 NA 5 29 8.64/8.23 NA 6 10 7.87/7.89 10 180 7 81 7.75/7.76 10 180 8 140 NA NA 9 11 9.27/8.87 10 180 10 47 7.64/7.35 NA 11 34 8.44/8.03 NA 12 31 7.68/8.26 NA 13 14 8.03/8.60 NA 14 7.6 8.76/8.64 35 > 180 15 10 8.79/8.85 60 > 180 16 20 8.42/8.77 45 > 180 17 17 8.78/8.63 10 180 18 12 8.79/8.64 65 > 180 19 9.2 8.43/8.36 50 > 180 20 16 9.17/8.86 75 > 180 21 20 9.14/9.15 40 > 180 22 5.4 8.75/8.89 30 > 180 23 99 9.04/8.60 NA 24 22 9.19/8.69 50 > 180 25 5.0 9.41/9.16 25 > 180 26 3.6 8.36/8.44 15 180 27 18 8.74/8.67 35 > 180 28 23 8.85/8.25 15 180 29 51 NA NA 30 65 NA NA 31 45 NA NA 32 5.4 8.80/9.04 50 > 180 33 9.4 NA 65 > 180 34 9.0 NA NA 35 14 NA NA 36 7.0 NA 75 120 37 4.8 NA 25 > 180 38 5.0 NA NA 39 14 7.45/7.87 20 > 180 40 91 NA NA 41 160 NA NA 42 93 NA NA 43 89 7.55/7.67 NA Also embraced within this invention is a class of pharmaceutical compositions comprising one or more compounds of Formula I in association with one or more nontoxic, pharmaceutically acceptable carriers and/or diluents and/or adjuvants (collectively referred to herein as "carrier" materials) and, if desired, other active ingredients. The compounds of the present invention may be administered by any suitable route, preferably in the form of a pharmaceutical composition adapted to such a route, and in a dose effective for the treatment intended. Therapeutically effective doses of the compounds of the present invention required to prevent or arrest the progress of the medical condition are readily ascertained by one of ordinary skill in the art. The compounds and composition may, for example, be administered intravascularly, intraperitoneally, subcutaneously, intramuscularly or topically. For oral administration, the pharmaceutical composition may be in the form of, for example, a tablet, capsule, suspension or liquid. The pharmaceutical composition is preferably made in the form of a dosage unit containing a particular amount of the active ingredient. Examples of such dosage units are tablets or capsules. These may with advantage contain an amount of active ingredient from about 1 to 250 mg, preferably from about 25 to 150 mg. A suitable daily dose for a mammal may vary widely depending on the condition of the patient and other factors. However, a dose of from about 0.1 to 3000 mg/kg body weight, particularly from about 1 to 100 mg/kg body weight, may be appropriate. The active ingredient may also be administered by injection as a composition wherein, for example, saline, dextrose or water may be used as a suitable carrier. A suitable daily dose is from about 0.1 to 100 mg/kg body weight injected per day in multiple doses depending on the disease being treated. A preferred daily dose would be from about 1 to 30 mg/kg body weight. Compounds indicated for prophylactic therapy will preferably be administered in a daily dose generally in a range from about 0.1 mg to about 100 mg per kilogram of body weight per day. A more preferred dosage will be a range from about 1 mg to about 100 mg per kilogram of body weight. Most preferred is a dosage in a range from about 1 to about 50 mg per kilogram of body weight per day. A suitable dose can be administered, in multiple sub-doses per day. These sub-doses may be administered in unit dosage forms. Typically, a dose or sub-dose may contain from about 1 mg to about 100 mg of active compound per unit dosage form. A more preferred dosage will contain from about 2 mg to about 50 mg of active compound per unit dosage form. Most preferred is a dosage form containing from about 3 mg to about 25 mg of active compound per unit dose. The dosage regimen for treating a disease condition with the compounds and/or compositions of this invention is selected in accordance with a variety of factors, including the type, age, weight, sex and medical condition of the patient, the severity of the disease, the route of administration, and the particular compound employed, and thus may vary widely. For therapeutic purposes, the compounds of this invention are ordinarily combined with one or more adjuvants appropriate to the indicated route of administration. If administered per os , the compounds may be admixed with lactose, sucrose, starch powder, cellulose esters of alkanoic acids, cellulose alkyl esters, talc, stearic acid, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulfuric acids, gelatin, acacia gum, sodium alginate, polyvinylpyrrolidone, and/or polyvinyl alcohol, and then tableted or encapsulated for convenient administration. Such capsules or tablets may contain a controlled-release formulation as may be provided in a dispersion of active compound in hydroxypropylmethyl cellulose. Formulations for parenteral administration may be in the form of aqueous or non-aqueous isotonic sterile injection solutions or suspensions. These solutions and suspensions may be prepared from sterile powders or granules having one or more of the carriers or diluents mentioned for use in the formulations for oral administration. The compounds may be dissolved in water, polyethylene glycol, propylene glycol, ethanol, corn oil, cottonseed oil, peanut oil, sesame oil, benzyl alcohol, sodium chloride, and/or various buffers. Other adjuvants and modes of administration are well and widely known in the pharmaceutical art.

Claims: A compound of Formula I wherein A is selected from wherein R 1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, cert-butyl, 4-methylbutyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclobutylmethyl, cyclobutylethyl, cyclopentylmethyl, cyclopentylethyl, cyclohexylmethyl, cyclohexylethyl cyclohexanoyl, methylbutyl, ethylbutyl, dimethylbutyl, thienylmethyl, thienylethyl, thienylpropyl, cyclopentenylmethyl, cyclopentenylethyl, cyclopentenylpropyl, cyclohexenyl, cyclohexenylmethyl, cyclohexenylethyl, adamantyl, adamantylmethyl, adamantylethyl, phenyl, chlorophenyl, dichlorophenyl, fluorophenyl, difluorophenyl, methoxyphenyl, ethoxyphenyl, methylphenyl, ethylphenyl, propylphenyl, isopropylphenyl, dimethylphenyl, diethylphenyl, benzyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R 2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopropylmethyl, cyclopropylethyl, cyclobutylmethyl, cyclobutylethyl, cyclopentylmethyl, cyclopentylethyl, cyclohexylmethyl, cyclohexylethyl, methylbutyl, ethylbutyl, dimethylbutyl, thienylmethyl, thienylethyl, thienylpropyl, cyclopentenylmethyl, cyclopentenylethyl, cyclopentenylpropyl, cyclohexenyl, cyclohexenylmethyl, cyclohexenylethyl, adamantyl, adamantylmethyl, adamantylethyl, phenyl, chlorophenyl, dichlorophenyl, fluorophenyl, difluorophenyl, methoxyphenyl, ethoxyphenyl, methylphenyl, ethylphenyl, propylphenyl, isopropylphenyl, dimethylphenyl, diethylphenyl, benzyl, propylthio, butylthio and hydroxyalkyl; wherein one of R 5 and R 9 is hydrogen and the other of R 5 and R 9 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Compound of Claim 1 selected from a family of compounds of Formula II wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio or hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmceutically-acceptable salt thereof. Compound of Claim 2, selected from compounds and their pharmaceutically-acceptable salts of the group of compounds consisting of 1-propyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[5-[2-(1H-tetrazol-5-yl)phenyl]-2-pyridinyl]methyl]-2H-imidazol-2-one. Compound of Claim 1 selected from a family of compounds of Formula III wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio or hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. A compound of Claim 4 selected from compounds and their pharmaceutically-acceptable salts of the group of compounds consisting of. 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1,4-dipropyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-propyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-isobutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-isopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-pentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-cyclohexyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-cyclopentyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-butyl-4-(2-cyclopropylethyl)-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-methyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-ethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-propyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-isobutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-isopropyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-tertbutyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-neopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(3,3-dimethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-cyclohexyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-cyclopropylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-cyclopentyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-cyclopentylmethyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-[2-(2-thienyl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-cyclopentylethyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-[2-(cyclopenten-1-yl)ethyl]-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(1-adamantyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-phenyl-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-chlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-methylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-methoxyphenyl)-4-butyl-1,3-dihydzo-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2-isopropylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2,6-difluorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; 1-(2,6-dichlorophenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one; and 1-(2,6-dimethylphenyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. Compound of Claim 1 selected from a family of compounds of Formula IV wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Compound of Claim 6 selected from compounds and their pharmaceutically-acceptable salts of the group of compounds consisting of 1-propyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. Compound of Claim 1 selected from a family of compounds of Formula V wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Compound of Claim 8 selected from compounds and their pharmaceutically-acceptable salts of the group of compounds consisting of 1-propyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[4-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. Compound of Claim 1 selected from a family of compounds of Formula VI wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Compound of Claim 10 selected from compounds and their pharmaceutically-acceptable salts of the group of compounds consisting of 1-propyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-(1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[3-1H-tetrazol-5-yl)-4-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. Compound of Claim 1 selected from a family of compounds of Formula VII wherein R 1 , R 2 are as defined in Claim 1, except that R 2 is not propylthio, butylthio, hydroxyalkyl; wherein R 5 is an acidic group selected from CO 2 H and or a tautomer thereof or a pharmaceutically-acceptable salt thereof. Compound of Claim 12 selected from compounds and their pharmaceutically-acceptable salts of the group of compounds consisting of 1-propyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1,4-dibutyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]ethyl]-2H-imidazol-2-one; 1-pentyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-isopentyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-cyclohexylmethyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-phenylmethyl-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenylmethyl]-2H-imidazol-2-one; 1-(2-cyclohexylethyl)-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one; 1-(2-phenylethyl)-4-butyl-1,3-dihydro-3-[[4-[2-(1H-tetrazol-5-yl)-3-pyridinyl]phenyl]methyl]-2H-imidazol-2-one. Compound of Claim 5 which is 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof. Compound of Claim 5 which is 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one. A pharmaceutical composition comprising a therapeutically-effective amount of an angiotensin-II antagonist and a pharmaceutically-acceptable carrier or diluent, said antagonist compound selected from a family of compounds according to any of Claims 1-15. A pharmaceutical composition according to Claim 16 wherein the angiotensin II antagonist is 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one o a pharmaceutically-acceptable salt thereof. A pharmaceutical composition according to Claim 16 wherein the angiotensin II antagonist is 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof. Use of a compound according to any of Claims 1-15 for preparing a medicament for treating a circulatory disorder. Use according to Claim 19 wherein said active compound is 1,4-dibutyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof. Use according to Claim 19 wherein said active compound is 1-(2-ethylbutyl)-4-butyl-1,3-dihydro-3-[[6-[2-(1H-tetrazol-5-yl)phenyl]-3-pyridinyl]methyl]-2H-imidazol-2-one or a pharmaceutically-acceptable salt thereof. Use according to Claim 19 wherein said circulatory disorder is a cardiovascular disorder. Use according to Claim 22 wherein said cardiovascular disorder is hypertension. Use according to Claim 22 wherein said cardiovascular disorder is congestive heart failure.

Inventors: MANNING ROBERT E, REITZ DAVID B, MANNING, ROBERT E., REITZ, DAVID B
Applicants: SEARLE & CO, G.D. SEARLE & CO.
Application year: 1992
Main classification: C07D401
IPC codes: C07D401