Process for the preparation of 4-hydroxy-3(2H)furanones

Abstract: The invention is directed to a process for the preparation of 5-alkyl-4-hydroxy-3[2H]furanones and/or 2,5-dialkyl-4-hydroxy-3[2H]furanones, wherein each alkyl group independently has one to six carbon atoms, comprising; (a) saponification of an ester selected from the group of 3,4-dihydroxyfurans substituted at the 2- and/or 5-position with one or two carbalkoxy groups, wherein each alkoxy group independently contains one to six carbon atoms, and optionally substituted at the 2- or 5-position with an alkyl group with one to six carbon atoms, or tautomeric forms or keto-enol isomers thereof; (b) subsequent treatment with one or two alkylation reagents which independently may have one to six carbon atoms; (c) subsequent recovery of the 5-alkyl-4-hydroxy-3[2H]furanones and/or 2,5-dialkyl-4-hydroxy-3[2H]furanones.

Description: This invention relates to a novel process for the preparation of 5-hydrocarbyl-4-hydroxy-3[2H]furanones and 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones or tautomeric forms thereof, wherein the hydrocarbyl radicals independently may consist of one to six carbon atoms. The furanones, subject of the present invention, are flavoring and perfume ingredients and have been widely utilized for the reconstitution of good quality flavors and fragrances. After their identification as volatile flavor component in nature, e.g. in pineapple (J.O. Rodin et al., J. Food Sci. 30 , 280 (1965)), 4-hydroxy-3[2H]furanones have found an ever increasing acceptation also based upon their versatility and applicability in a great variety of different flavor types. Their use in flavoring agents has been described in, for example, German patent application No.1,915,788 for bakery products, Dutch patent application No. 70 04,150 for meat flavors, German patent applications No. 2,202,065 and No. 2,202,066 for tobacco flavoring, Swiss patent No. 540,650 for cooked fruit flavors and European patent application No. 0,167,214 as a sugar simulating compound. Their use as perfume ingredient is described in, for example, German patent application No. 2,509,668 and their use in insect attractant compositions is mentioned in US patent 4,447,447. For the preparation of 2,5-dialkyl-4-hydroxy-3[2H]furanones many synthetic routes have been suggested. However, all of these either are laborious non-economical laboratory methods with low overall yields, or use rare, expensive, dangerous and toxicologically undesirable methods and/or raw materials. Methods heretofore proposed for the preparation of 5-alkyl-4-hydroxy-3[2H]furanones and 2,5-dialkyl-4-hydroxy-3[2H]furanones have been described, for example, in the German patent applications No. 1,932,799, 2,163,223, 2,359,891, 2,812,713 and 2,845,843, Swiss patent No. 491,904, European patents No. 0,000,907 and 0,055,976 in Japanese patent application No. 79,115,369 and by L. Re et al., Helv.Chim.Acta 56 (6),1882 (1973), M. Baumann et al., Synthesis 1981 (9), 709 and C.H. Wong et al., J. Org. Chem. 48 (20), 3493 (1983). These methods of preparation comprise cyclization of straight chain compounds of proper oxidation level, and oxidations of 3[2H]furanone derivatives. In German patent application 2,812,713 alkylation of sodium salts of 2-carbalkoxy-5-alkyl-3,4-dihydroxyfuran is set forth. This method requires large excesses of the alkylation agent, very long reaction periods at elevated temperatures, which is unfavorable for both purity and yield because of the general thermolability of 4-hydroxy-3[2H]furanones, water-free conditions, nitrogen atmosphere and complex systems of organic solvents. Yields are moderate to low. As an explicit condition for this method of preparation it is claimed that the alkylation step of sodium salts of 2-carbalkoxy-5-alkyl-3,4-dihydroxyfuran is performed prior to the hydrolysis of the carbethoxy group of the resultant reaction product. According to the present invention, it has been found unexpectedly that 5-hydrocarbyl-4-hydroxy-3[2H]furanones and 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones can be prepared in good yields in a technically very simple and commercially very attractive way, using readily accessible, abundantly available basic chemicals. This process can easily be carried out in an aqueous medium. The process of the invention comprises (a) saponification of an ester selected from the group of 3,4-dihydroxyfurans substituted at the 2- and/or 5-position with one or two carbalkoxy groups, wherein the alkoxy groups independently contain one to six carbon atoms or tautomeric forms or keto-enol isomers thereof; (b) subsequent treatment of the hydrolysate with one or two hydrocarbylation reagents by which one or two hydrocarbyl group are introduced, which groups independently may contain one to six carbon atoms; (c) recovery of the 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones. It should be understood that, because of the tautomeric nature of the subject compounds, when mentioning a 4-hydroxy-3[2H]furanone the tautomeric form is also included. The starting ester used in the saponification is optionally substitued at the 2 or 5 position with a hydrocarbyl group, as defined above, with one to six carbon atoms. The hydrocarbyl groups in the 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones are selected from the group of alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups of at most six carbon atoms. More in particular the alkyl groups are independently from each other selected from methyl, ethyl and n -hexyl groups. The starting esters for the process of the present invention are easily prepared according to methods known to the art e.g. according to the method of British patent No. 1,601,934. It should be understood, that according to that method, mixtures of different esters are obtained with respect to the alkyl moiety of the carbalkoxy group in case the starting materials and the alkaline condensing agent contain different alkoxy groups. According to the present invention such mixtures of different esters are equally suitable for the preparation of 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones as the single esters. The invention is based on the surprising and unexpected finding that it is possible to hydrocarbylate, more in particular to alkylate the carboxylic acid salt, with simultaneous decarboxylation. This finding has opened the route to various advantageous and easy preparation methods for the present product. Suitable furanones prepared in accordance with the present invention are 4-hydroxy-3[2H]furanones selected from the group 2-methyl-4-hydroxy-3[2H]furanone, 5-methyl-4-hydroxy-3[2H]furanone, 2,5-dimethyl-4-hydroxy-3[2H]furanone, 2-ethyl-4-hydroxy-3[2H]furanone, 5-ethyl-4-hydroxy-3[2H]furanone, 2-methyl-5-ethyl-4-hydroxy-3[2H]furanone and 2-ethyl-5-methyl-4-hydroxy-3[2H]furanone, prepared according to the process of claim 1 or claim 4. The hydrolysis of the starting esters of the process of the invention can be performed according to the methods known to the art for effecting hydrolysis of esters in general. For economical and practical reasons the hydrolysis preferably is carried out in an aqueous medium by the use of an alkali metal hydroxide, such as lithium hydroxide, sodium hydroxide and potassium hydroxide. The temperature of the hydrolysis step and the amounts of base and solvent used are not critical. Suitable temperatures range from 0 to 100°C, practicably avantageously, temperatures around room temperature are practised. The preferred solvent is water. Because of the acidic nature of the hydroxyl moieties in the starting esters the amount of base, such as sodium hydroxide or potassium hydroxide employed should compensate for the neutralization effect in order to create a basicity high enough to effect the hydrolysis under alkaline conditions. Preferably the amount of base used ranges from 3 to 7 molar equivalents of the amount of starting esters. The hydrocarbylation reagents effective in the process of the present invention can be chosen from the wide variety of reagents known as hydrocarbylation agents to the art suitable to introduce hydrocarbyl moieties from one to six carbon atoms e.g. hydrocarbyl halides, hydrocarbyl sulphates, hydrocarbyl arylsulphates, hydrocarbyl carbonates and the like, whether or not in conjunction with activators like iodine, iodides and the like. The hydrocarbyl moiety has preferably one to six carbon atoms. Most preferred are hydrocarbyl chlorides, hydrocarbyl bromides and hydrocarbyl sulfates. Suitable temperatures for the reaction range from 0 to 100°C, whereby the preferred temperatures are around room temperature, i.e. from about 15 to about 30°C. According to the present invention the starting esters may also be processed as intermediate reaction products without prior isolation e.g. from the process set forth in German patent 2,812,713 describing the condensation of dialkyl alpha-alkyldiglycolic esters with dialkyl oxalates. Accordingly a preferred embodiment of the invention comprises a process for the preparation of 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones, wherein each hydrocarbyl represents a group independently selected from alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups of at most six carbon atoms, comprising; (a) condensing a dialkyl diglycolate or a dialkyl 2-hydrocarbyl-glycolate, wherein each alkyl group independently has one to six carbon atoms, if applicable, substituted at the 2-position with a hydrocarbylgroup as defined above with one to six carbon atoms, with a dialkyl oxalate, wherein each alkyl group independently contains one to six carbon atoms in the presence of an alkaline condensing agent; (b) subsequent saponification of at least one of the carbalkoxy moieties of the resulting product; (c) subsequent treatment with one or two hydrocarbylation reagents containing a hydrocarbyl group as defined above, which independently have one to six carbon atoms; (d) subsequent recovery of the 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones. The following examples illustrate the invention. Example 1 A solution of 48 g sodium hydroxide and 37.2 g of ethyl 5-methyl-3,4-dihydroxy-2-furoate of 98.4% purity in 225 ml water was allowed to stand at roomtemperature for 40 hours. The mixture was diluted with 200 g water and 22.8 g gaseous methyl bromide was added with stirring over a period of one hour at roomtemperature followed by an additional stirring period of two hours. The pH of the solution was adjusted to 5 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t -butyl ether yielded 21.5 g 2,5-dimethyl-4-hydroxy-3[2H]furanone of 95.3% purity (molar yield 81.4%). Example 2 A solution of 32 g sodium hydroxide and 33 g of a mixture containing 37.1% methyl 5-methyl-3,4-dihydroxy-2-furoate and 52.1% ethyl 5-methyl-3,4-dihydroxy-2-furoate in 320 ml water was allowed to stand at roomtemperature for 20 hours. To the resulting mixture is added at 0°C in one hour 25.2 g dimethyl sulphate followed by an additional stirring period of three hours at 0°C. The pH of the solution was adjusted to 6.5 by the adddition of concentrated hydrochloric acid solution. Extraction with methyl t -butyl ether yielded 18.1 g 2,5-dimethyl-4-hydroxy-3[2H]furanone of 88.8% purity (molar yield 76.6%). Example 3 To a suspension of 113.4 g sodium methylate in 750 g methyl t -butyl ether was added at 5°C in one hour 146 g diethyl oxalate followed by a stirring period of one hour at 5°C. Then 204 g diethyl 2-methyldiglycolate in two hours was added at 5°C and the mixture was stirred for four hours at that temperature followed by a reflux period of three hours. The reaction mixture is added to 797 g 8.9% hydrochloric acid solution at 20°C and the pH of the resulting mixture is adjusted to 5 with 33% sodium hydroxide solution. To the separated upper layer is added with stirring 903 g 17.8% sodium hydroxide solution at 20°C. The layers are allowed to settle and the separated lower layer is kept at 20°C for 20 hours. Then 200 g water is added, 104 g methyl bromide is introduced at 20°C in one hour, the mixture is stirred for another hour and the pH of the solution was adjusted to 6.5 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t -butyl ether yielded 95 g 2,5-dimethyl-4-hydroxy-3[2H]furanone of 97.3% purity (molar overall yield 72.2%). Example 4 A solution of 20 g sodium hydroxide and 24.4 g of diethyl 3,4-dihydroxy-2,5-difuroate in 180 ml water was allowed to stand at roomtemperature for 45 hours. Then 48 g methyl bromide was introduced in 5 hours at roomtemperature. The pH of the solution was adjusted to 5 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t -butyl ether yielded 9 g of 2,5-dimethyl-4-hydroxy-3[2H]furanone of 86.6% purity (molar yield 60.9%). Example 5 A solution of 108 g sodium hydroxide and 116 g of methyl 5-methyl-3,4-dihydroxy-2-furoate of 94% purity in 935 ml water was allowed to stand at roomtemperature for 20 hours. Then 88 g ethyl bromide was added in one hour at roomtemperature followed by an additional stirring period of four hours. The pH of the solution was adjusted to 6 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t -butyl ether and flash-distillation yielded 82 g of an isomeric mixture of 2-ethyl-5-methyl-4-hydroxy-3[2H]furanone and 2-methyl-5-ethyl-4-hydroxy-3[2H]furanone of 92.2% purity (molar yield 84.0%), b.p. 95-100°C at 0.3 mm Hg. Example 6 A solution of 48 g sodium hydroxide and 37.2 g of ethyl 5-methyl-3,4-dihydroxy-2-furoate of 95.3% purity in 225 ml water was allowed to stand at roomtemperature for 40 hours. Then 34 g ethyl iodide was added in one hour at roomtemperature followed by an additional stirring period of six hours. The pH of the solution was adjusted to 6 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t -butyl ether and flash-distillation yielded 22.9 g of an isomeric mixture of 2-ethyl-5-methyl-4-hydroxy-3[2H]furanone and 2-methyl-5-ethyl-4-hydroxy-3[2H]furanone of 92.6% purity (molar yield 78.3%). Example 7 Example 3 was repeated at a four times larger scale and substituting methyl bromide with an equimolar amount of ethyl bromide yielding 367 g of an isomeric mixture of 2-ethyl-5-methyl-4-hydroxy-3[2H]furanone and 2-methyl-5-ethyl-4-hydroxy-3[2H]furanone of 96.3% purity (molar overall yield 62.2%). Example 8 A solution of 32 g sodium hydroxide and 34.4 g of methyl 5-methyl-3,4-dihydroxy-2-furoate of 99.8% purity in 235 ml water was allowed to stand at roomtemperature for 20 hours. Then 49.2 g n -propyl bromide was added at roomtemperature followed by and additional stirring period of 20 hours. The pH of the solution was adjusted to 6 by the addition of concentrated hydrochloric acid solution. Extraction with methyl t -butyl ether yielded 25.3 g of an isomeric mixture of 2- n -propyl-5-methyl-4-hydroxy-3[2H]furanone and 2-methyl-5- n -propyl-4-hydroxy-3[2H]furanone of 81.8% purity (molar yield 66.5%), b.p. 95-100°C at 0.2 mm Hg. Example 9 Example 6 was repeated substituting ethyl iodide with 49.2 g i -propyl bromide yielding 17 g of an isomeric mixture of 2- i -propyl-5-methyl-4-hydroxy-3[2H]furanone and 2-methyl-5- i -propyl-4-hydroxy-3[2H]furanone of 93.2% purity (molar yield 53.3%), b.p. 78-83°C at 0.2 mm Hg. Example 10 Example 1 was repeated at half the scale and substituting methyl bromide with 29.8 g cyclopentyl bromide yielding 9.3 g of an isomeric mixture of 2-cyclopentyl-5-methyl-4-hydroxy-3[2H]furanone and 2-methyl-5-cyclopentyl-4-hydroxy-3[2H]furanone of 92.5% purity (molar yield 48.1%), b.p. 120-125°C at 0.2 mm Hg.

Claims: A process for the preparation of 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones, wherein each hydrocarbyl represents a group independently selected from alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups of at most six carbon atoms, comprising; (a) saponification of an ester selected from the group of 3,4-dihydroxyfurans substituted at the 2- and/or 5-position with one or two carbalkoxy groups, wherein each alkoxy group independently contains one to six carbon atoms, and optionally substituted at the 2- or 5-position with a hydrocarbyl group as defined above with one to six carbon atoms, or tautomeric forms or keto-enol isomers thereof; (b) subsequent treatment with one or two hydrocarbylation reagents, containing a hydrocarbyl group as defined above, which independently may have one to six carbon atoms; (c) subsequent recovery of the 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones. A process according to claim 1 wherein at least one of the hydrocarbyl groups is selected from the group of alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups of at most six carbon atoms. A process according to claim 1 wherein the hydrocarbyl groups independently are selected from methyl, ethyl and n -hexyl groups. A process for the preparation of 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones, wherein each hydrocarbyl represents a group independently selected from alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups of at most six carbon atoms, comprising; (a) condensing a dialkyl diglycolate or a dialkyl 2-hydrocarbyl-glycolate, wherein each alkyl group independently has one to six carbon atoms and, if applicable, substituted at the 2-position with a hydrocarbylgroup as defined above with one to six carbon atoms, with a dialkyl oxalate, wherein each alkyl group independently contains one to six carbon atoms in the presence of an alkaline condensing agent; (b) subsequent saponification of at least one of the carbalkoxy moieties of the resulting product; (c) subsequent treatment with one or two hydrocarbylation reagents containing a hydrocarbyl group as defined above, which independently have one to six carbon atoms; (d) subsequent recovery of the 5-hydrocarbyl-4-hydroxy-3[2H]furanones and/or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanones. A process according to claim 4 wherein at least one of the hydrocarbyl groups is selected from the group of alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups of at most six carbon atoms. A process according to claim 4 wherein the hydrocarbyl groups independently are selected from methyl, ethyl and n -hexyl groups. A 5-hydrocarbyl or 2,5-dihydrocarbyl-4-hydroxy-3[2H]furanone wherein the 5-hydrocarbyl group and at least one of the 2,5-dihydrocarbyl groups is selected from the group of alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups of at most six carbon atoms.

Inventors: COHEN AMNON MORDECHAI, LENSELINK WILLEM, VAN EK CORNELIS, COHEN, AMNON MORDECHAI, LENSELINK, WILLEM, VAN EK, CORNELIS
Applicants: TASTEMAKER BV, TASTEMAKER B.V.
Application year: 1992
Main classification: C07D307
IPC codes: C07D307