Process for the preparation of intermediates for oxime ether- or 2-phenyl-3-methyl propenoate-fungicides

Abstract: Fungicidal compounds having the formula (I): wherein W is CH₃O.CH=CCO₂CH₃, CH₃ON=CCONR³R⁴ or CH₃ON=CCO₂CH₃ and stereoisomers thereof; n is O or 1; X is oxygen or sulphur; Z is oxygen, sulphur or NR¹; R¹ is hydrogen or alkyl optionally substituted with halogen, C₁₋₆ alkoxy, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl or aryl; R² is alkyl, haloalkyl, alkenyl, alkynyl, alkoxycarbonyl(C₁₋₄)alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryl(C₁₋₄)alkyl, optionally substituted heteroaryl(C₁₋₄)alkyl, optionally substituted aryloxy(C₁₋₄)alkyl, optionally substituted heteroaryloxy(C₁₋₄)alkyl, optionally substituted aryloxy(C₂₋₄)alkenyl, optionally substituted heteroaryloxy(C₂₋₄)alkenyl, optionally substituted aryl(C₂₋₄)alkenyl, optionally substituted heteroaryl(C₂₋₄)alkenyl, optionally substituted arylcarbonyl(C₁₋₄)alkyl, optionally substituted heteroarylcarbonyl(C₁₋₄)alkyl, optionally substituted aryloxycarbonyl(C₁₋₄)alkyl, optionally substituted heteroaryloxycarbonyl-(C₁₋₄)alkyl or -COR⁵; or R¹ and R² together form an optionally substituted 4-, 5- or 6-membered heterocyclic ring system; R³ and R⁴ are independently hydrogen or methyl; and R⁵ is optionally substituted heteroaryl or optionally substituted aryl; and processes for preparing, compositions comprising and methods of combating fungi using compounds of formula (I). Also provided is a process for the preparation of a compound of formula (XX): wherein p is 0 or 1.

Description: The present invention relates to a process for the preparation of chemical intermediates useful for preparing fungicidal carbonate, carbamate, thiocarbonate, dithiocarbonate and thiocarbamate derivatives. It also relates to certain of the intermediates themselves. European patent No. 0606251, of which the present application is a divisional, claims a compound having the general formula (I), wherein W is CH 3 O.CH=CCO 2 CH 3 , CH 3 ON=CCONR 3 R 4 or CH 3 ON=CCO 2 CH 3 and stereoisomers thereof; n is O or 1; X is oxygen or sulphur; Z is oxygen, sulphur or NR 1 ; R 1 is hydrogen or alkyl optionally substituted with halogen, C 1-6 alkoxy, C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl or aryl; R 2 is alkyl, haloalkyl, alkenyl, alkynyl, alkoxycarbonyl(C 1-4 )alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryl(C 1-4 )alkyl, optionally substituted heteroaryl(C 1-4 )alkyl, optionally substituted aryloxy(C 1-4 )alkyl, optionally substituted heteroaryloxy(C 1-4 )alkyl, optionally substituted aryloxy(C 2-4 )alkenyl, optionally substituted heteroaryloxy(C 2-4 )alkenyl, optionally substituted aryl(C 2-4 )alkenyl, optionally substituted heteroaryl(C 2-4 )alkenyl, optionally substituted arylcarbonyl(C 1-4 )alkyl, optionally substituted heteroarylcarbonyl(C 1-4 )alkyl, optionally substituted aryloxycarbonyl(C 1-4 )alkyl, optionally substituted heteroaryloxycarbonyl(C 1-4 )alkyl or -COR 5 ; or R 1 and R 2 together form an optionally substituted 4-, 5- or 6-membered heterocyclic ring system; R 3 and R 4 are independently hydrogen or methyl; and R 5 is optionally substituted heteroaryl or optionally substituted aryl; provided that when W is CH 3 O.CH=CCO 2 CH 3 , n is 1 and X and Z are both oxygen then R 2 is not optionally substituted aryl. Because the double bond of the propenoate, oxyiminoacetamide or oxyiminoacetate group is unsymmetrically substituted, the compounds of EP 0606251 may be obtained in the form of mixtures of (E)- and (Z)-geometric isomers which can be separated into individual isomers. The (E)-isomers are the more fungicidally active and form a preferred embodiment. The present invention relates, in particular, to a process for the preparation of oxime ether amides which are useful intermediates for the preparation of compounds claimed in EP 0606251 of formula (X). According to the present invention there is provided a process for the preparation of a compound of formula (XX), wherein p is 0 or 1, the process comprising reacting a compound of formula (XXIII), wherein p is 0 or 1, with methylamine. In one particular aspect the present invention provides a process for the preparation of a compound of formula (XX), wherein p is 0 or 1, the process comprising the steps: (a) reacting a compound of formula (XXII), wherein p is 0 or 1, with a methylating agent, in the presence of a base (for example an alkali metal carbonate or hydroxide or sodium hydride) to form a compound of formula (XXIII), wherein p is 0 or 1; and, (b) reacting the compound of formula (XXIII), wherein p is 0 or 1, with methylamine. In a further aspect the present invention provides a process for the preparation of a compound of formula (XX), wherein p is 0 or 1, the process comprising the steps: a) reacting a compound of formula (XXI), wherein p is 0 or 1, with an alkyl nitrite in the presence of an acid or base to produce a compound of formula (XXII), wherein p is 0 or 1; b) reacting the compound of formula (XXII), wherein p is 0 or 1, with a methylating agent in the presence of a base to form a compound of formula (XXIII), wherein p is 0 or 1; and, c) reacting the compound of formula (XXIII), wherein p is 0 or 1, with methylamine. In another aspect the present invention provides a process for the preparation of a compound of formula (XX), wherein p is 0 or 1, the process comprising the steps: a) reacting a compound of formula (XXI), wherein p is 0 or 1, with an alkyl nitrite in the presence of an acid (for example hydrogen chloride) or a base (for example an alkali metal alkoxide) to produce a compound of formula (XXII), wherein p is 0 or 1; b) reacting the compound of formula (XXII), wherein p is 0 or 1, with a methylating agent, in the presence of a base (for example an alkali metal carbonate or hydroxide or sodium hydride) to form a compound of formula (XXIII), wherein p is 0 or 1; and c) reacting the compound of formula (XXIII), wherein p is o or 1, with methylamine. Steps (a) and (b) above can be combined to give a "one-pot" process. Therefore, in a further aspect, the present invention provides a process for the preparation of a compound of formula (XX), wherein p is 0 or 1, the process comprising the steps of: i) treating a compound of formula (XXI) with a base (for example an alkali metal alkoxide); ii) treating the product of (i) with an alkyl nitrite; iii) treating the product of (ii) with a methylating agent to form a compound of formula (XXIII); and, iv) reacting the compound of formula (XXIII), wherein p is 0 or 1, with methylamine. The alkyl moiety of an alkyl nitrite is a straight or branched chain and preferably contains from 1 to 10, (for example from 4 to 8) carbon atoms, and is, for example, a tert -butyl or iso -amyl moiety. Alkali metals include sodium or potassium. The alkoxide moiety is especially C 1-4 alkoxide, for example methoxide, ethoxide or tert -butoxide. Methylating agents are compounds of formula CH 3 L, wherein L is a leaving group (for example halogen), and are, for example, methyl iodide or dimethyl sulphate. It is preferred that the present invention provides a process for the preparation of a compound of formula (XX) wherein p is 1. A compound of formula (XX) can be prepared by reacting a compound of formula (XXIII) with methylamine in a suitable solvent (such as methanol or ethanol). A compound of formula (XXIII) can be prepared by treating a compound of formula (XXII) with a suitable base (such as sodium or potassium carbonate or hydroxide or sodium hydride) and a methylating agent (such as methyl iodide or dimethyl sulphate) in a suitable solvent (such as N , N -dimethylformamide). Alternatively, a compound of formula (XXIII) can be prepared by treating a compound of formula (XXI) with a base (such as potassium tert -butoxide) in a suitable solvent (such as tert -butanol), treating this mixture with an alkyl nitrite (such as tert -butyl nitrite) and then adding a methylating agent (such as methyl iodide or dimethyl sulphate) to the reaction mixture. A compound of formula (XXII) can be prepared by treating a compound of formula (XXI) with a base (such as sodium methoxide) in a suitable solvent (such as methanol) in the presence of an alkyl nitrite (for example tert -butyl nitrite). Alternatively, a compound of formula (XXII) can be prepared by treating a compound of formula (XXI) with an acid (such as hydrogen chloride) in a suitable solvent (such as methanol or ethanol) in the presence of an alkyl nitrite (for example tert -butyl nitrite). Compounds of formula (XXI) are known in the literature. The compound of formula (XX), wherein p is 1, is known and is used in EP-A2-0398692 as an intermediate for fungicides. The compound of formula (XXII), wherein p is 0, and its preparation by reacting the compound (XXI), wherein p is 0, in a solvent with nitrous acid or a derivative of nitrous acid, is known from GB-A-1363788. The compound of formula (XXII), wherein p is 1, and its preparation by adding the compound (XXI), wherein p is 1, and n -butyl nitrite to sodium ethoxide, is known from Can. J. Chem. 60 (1982), 2678-86. In another aspect the present invention provides the intermediate compounds of formula (XXIII), wherein p is 0 or 1. The following Example illustrates the invention. Where shown, NMR data are selective; no attempt has been made to list every absorption in all cases. The following abbreviations are used throughout: m.p. = melting point d = doublet m = multiplet s = singlet dt = doublet of triplets brs = broad singlet EXAMPLE This Example illustrates the preparation of N-methyl-2-(2-hydroxymethylphenyl)-2-methoxyiminoacetamide. Step 1 A solution of sodium methoxide (5.5mmol) in methanol (5ml) was added to a stirred solution of 3-isochromanone (0.74g) and tert-butyl nitrite (1.55g) in methanol (10ml) under an atmosphere of nitrogen at room temperature. The temperature rose from 19°C to 23°C. After stirring at room temperature for 3 hours the methanol was removed under reduced pressure. The resulting residue was dissolved in water (15ml), filtered to remove insoluble matter and acidified with 2M hydrochloric acid (3ml). The brown precipitate formed was filtered off to give a pale brown solid (0.41g, 46%). Extraction of the aqueous solution with ethyl acetate gave a further 0.14g of impure product. The pale brown solid and impure product were together recrystallised from ethyl acetate to give isochroman-3,4-dione 4-oxime as a pale brown solid (0.14g, m.p. 181-185°C); 1 H NMR (d 6 -DMSO) δ 5.35(s,2H), 7.3(m,lH), 7.45(m,2H), 8.45(m,1H), 12.9(brs,lH) ppm. Step 2 Isochroman-3,4-dione 4-oxime (3.27g) was dissolved in N , N -dimethylformamide at 0°C. Potassium carbonate (2.55g) was added to the reaction mixture over 5 minutes. A solution of dimethyl sulphate (1.75ml) in N , N -dimethylformamide (5ml) was added to the reaction mixture. After stirring for 4 hours at 0°C the reaction mixture was poured into water and extracted three times with diethyl ether. The combined organic layers were washed three times with water, dried over magnesium sulphate and concentrated to a red oil (2.03g). The combined aqueous layers were extracted three times with ethyl acetate and the organic extracts dried over magnesium sulphate. The solvent was removed under reduced pressure to give a further 0.52g of a red oil. The combined samples of red oil were purified using a column of silica gel eluting with diethyl ether/hexane (3:1) to give isochroman-3,4-dione 4- O -methyloxime as a solid (1.15g, m.p. 84-85°C); 1 H NMR (CDCl 3 ) δ 4.2(s,3H), 5.35(s,2H), 7.3(m,1H), 7.45(m,2H), 8.3(m,1H) ppm. Step 3 Isochroman-3,4-dione 4- O -methyloxime (1.08g) was dissolved in tetrahydrofuran and a solution of methylamine in ethanol (2.5ml of a 35% W/V solution) was added in one portion. After stirring at room temperature for 1½ hours the reaction mixture was concentrated under reduced pressure to give a brown solid. Recrystallisation from ethyl acetate gave the title compound as a white solid (0.86g, 68%); 1 H NMR (CDCl 3 ) δ 2.95(d,3H), 3.2(t,1H), 3.95(s,3H), 4.4(d,2H), 6.95(brs,1H), 7.1(d,1H), 7.4(dt,2H), 7.5(d,1H) ppm.

Claims: A process for the preparation of a compound of formula (XX): wherein p is 0 or 1, the process comprising reacting a compound of formula (XXIII): wherein p is 0 or 1, with methylamine. A process according to claim 1 which comprises the additional step of forming the compound of formula (XXIII) by reacting a compound of formula (XXII): wherein p is 0 or 1, with a methylating agent in the presence of a base. A process according to claim 2 which comprises the additional step of producing the compound of formula (XXII) by reacting a compound of formula (XXI): wherein p is 0 or 1, with an alkyl nitrite in the presence of an acid or base. The intermediate compounds of formula (XXIII): wherein p is 0 or 1.

Inventors: CLOUGH JOHN MARTIN, GODFREY CHRISTOPHER RICHARD AY, MATTHEWS IAN RICHARD, CLOUGH, JOHN MARTIN, GODFREY, CHRISTOPHER RICHARD AYLES, MATTHEWS, IAN RICHARD
Applicants: ZENECA LTD, ZENECA LIMITED
Application year: 1992
Main classification: C07C249
IPC codes: C07C249, C07D213, C07C251, C07C329, C07C69, C07D295, C07C333, A01N47, C07D311, C07C323, C07C271, C07D241, C07D237, C07D277, C07C269, C07C327, C07C317, C07C68, C07D209, C07D239