Cyclic amide derivatives

Abstract: The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6, provided that the cyclic amide compound is quinazoline-on or quinazoline-dion, R2 and R4 are neither aryl nor substituted aryl. The cyclic amide compound is pharmacologically effective to prevent and treat diseases due to insufficiency of the central choline functions.

Description: The present invention relates to new cyclicamide derivatives such as piperidine compounds having excellent medicinal effects. [Prior Art] With a rapid increase in the population of the aged, the establishment of medical treatment for senile dementia such as Alzheimer's disease is eagerly demanded. Although various treatments of the senile dementia with medicineswere have been attempted, no medicine essentially effective for these diseases has been developed as yet. Various investigations are in progress for the purpose of developing therapeutic agents for these diseases. Particularly, the development of acetylcholine precursors and acetylcholine esterase inhibitors has been proposed, since Alzheimer's disease is attended with cerebral cholinergic hypofunction, and they are on actual test. Typical examples of the anticholinergic esterase inhibitors include physostigmine and tetrahydroaminoacridine. However, they have defects that their effects are yet insufficient and that they have adverse reactions unfavorably. Thus there are no decisive therapeutic agents at present. EP-A-0 326 106 discloses alkylene diamines containing a cyclic amide ring for use in a cholinesterase inhibiting agent. EP-A-0 296 560 and EP-A-0 229 391 both disclose piperidine derivatives optionally containing a cyclic amide group and showing cholinesterase inhibiting activity. EP-A-O 468 187 represents the parent application of this invention and discloses a compound of structure (Ia): EP-A-0 029 707 relates to piperidine derivatives having a pharmacologically useful hypotensive activity and, in particular, discloses a compound of structure (Ib): ( Summary of the invention ) Under these circumstances, the inventors have made intensive investigations of various compounds for a long period of time for the purpose of developing a medicine having a high safety and a long-lasting effect. As the result, the inventors have found that the purpose can be attained by using derivatives of the general formula (I) given below. In particular, the compounds of the present invention represented by the structural formula (I) given below have features that they have a potent, highly selective antiacetylcholine esterase activity to increase the quantity of acetylcholine in the brain, that they are effective for the therapy of models of the disturbance of memory and that their effect lasts for a longer time and they have a higher safety than those of physostigmine frequently used in this field. The present invention is thus highly valuable. The compounds of the present invention have been found on the basis of acetylcholine esterase inhibition and, therefore, they are effective for the treatment and prevention of various diseases due to insufficiency of the central choline functions, i.e. lack of acetylcholine as the neurotransmitter in vivo . Typical examples of such diseases include dementias represented by Alzheimer's presbyophrenia. They include also Huntington's chorea, Pick's disease and tardive dyskinesia. Therefore, objects of the present invention are to provide new piperidine derivatives usable as a medicine and particularly effective for the treatment and prevention of central nervous diseases, to provide a process for producing these new piperidine derivatives and to provide medicines comprising the piperidine derivative as the active ingredient. The invention provides a cyclic amide derivative having the formula (I) or a pharmacologically acceptable salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6. When Z is (1), it is preferable that R2 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxolane-2-yl, n is 1 or 2, m is 1 or 2 and the cyclic amide compound for R1 is selected from 2H-3,4-dihydro-1,3-benzoxazin-2-on and 2H-3,4-dihydro-1,3-benzoxazin-2,4-dion. It is preferable that R1 is substituted with a lower alkyl or a lower alkoxy. When Z is (2), it is preferable that R3 is a lower alkyl and R4 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxolane-2-yl. In the formula (I), the following compounds are most preferable: 3-(2-(1-benzyl-4-pyperidyl)ethyl)-5-methoxy-2H-3,4-dihydro-1,3-benzoxazine-2-on, 3-(2-(1-(4-pyridylmethyl)-4-pyperidyl)ethyl)-2H-3,4-dihydro-1,3-benzoxazine-2-on, 3-(2-(1-(1,3-dioxolane-2-yl-methyl)-4-pyperidine)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazine-2-on, 3-(2-(cylcopentylmethyl-4-pyperidyl)ethyl)-2H-3,4-dihydrol-1,3-benzoxazine-2,4-dion, 3-(2-(1-(1,3-dioxolane-2-yl-methyl)-4-pyperidyl)ethyl)-2H-3,4-dihydro-1,3-benzoxazine-2,4-dion, 3-(2-(1-benzyl-4-pyperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazine-2-on and 3-(2-(1-benzyl-4-pyperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazine-2,4-dion. The invention relates to the pharmacological use of the cyclic amide compound having the formula (I) and therefore provides a phamaceutical composition comprising a pharmacologically effective amount of the cyclic amide derivative as defined above and a pharmacologically acceptable carrier and then a method for preventing and treating diseases due to insufficiency of the central choline functions by administering a pharmacologically effective amount of the derivative as defined above to a human patient suffering from the diseases. The compound having the formula (I) includes that having the following formula (I'), called piperidine derivatives: wherein R represents a monovalent group derived from a substituted or unsubstituted cyclic amide compound, X represents a group of the formula: -(CH 2 ) n - (wherein n is an integer of 1 to 6), R 2 represents a group of the formula: -(CH 2 ) m -A (wherein m is an integer of 1 to 6 and A is an aryl group which may be substituted, a cycloalkyl group, a pyridyl group, a 1,3-dioxolan-2-yl group, a furyl group, a thienyl group or a tetrahydrofuryl group), and symbol represents a single bond, or pharmacologically acceptable salts thereof. The monovalent groups derived from the cyclic amide compounds in the definition of the compound (I) of the present invention include 2H-3,4-dihydro-1,3-benzoxazin-2-one and 2H-3,4-dihydro-1,3-benzoxazine-2,4-dione. The cyclic amides are those derived from monocyclic or condensed heterocyclic compounds. Preferable condensed heterocycles include heterocycles condensed with a benzene ring. The benzene ring may be substituted with one or two halogen atoms, preferably fluorine, chlorine or bromine, 1 to 3 lower alkoxy groups having 1 to 6 carbon atoms, preferably methoxy group, a lower alkyl group having 1 to 6 carbon atoms, or an amino, acetylamino or nitro group. The term "lower alkyl groups" in the above definition include straight-chain and branched alkyl groups having 1 to 6 carbon atoms, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl (amyl), isopentyl, neopentyl, tert-pentyl, 1-methylbutyl, 2-methylbutyl, 1,2-dimethylpropyl, hexyl, isohexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 2,2-dimethylbutyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl groups. Among them, preferred are methyl, ethyl, propyl and isopropyl groups and the most desirable is a methyl group and ethyl group. The term "lower alkoxy groups" refers to lower alkoxy groups having 1 to 6 carbon atoms derived from the above-described lower alkyl groups. Among them, the most desirable lower alkoxy groups include methoxy, ethoxy and n-propoxy groups. Preferred examples of the groups derived from the cyclic amide compounds include the following compounds: The group U is, independently of one another, hydrogen, a lower alkyl, a lower alkoxy, a halogen, an acyl, an amino or nitro. l is an integer of 1 to 4. k is 1 or 2. The formulae j and k has a 7-membered ring at the rightmost part and n has that at the center. In the invention, n is preferably zero or an integer of 1 to 6 when Z is (1). n is more preferably 1 or 2 and most preferably 2. n is preferably an integer of 3 to 7 when Z is (2). n is more preferably 4 to 6 and most preferably 5. Among (c) to (d) for R1, (d) is most preferable. R1 may have a substituent on the ring, preferably a lower alkyl such as methoxy or a lower alkoxy such as methoxy. Methoxy on the benzene ring is most preferable for (d) of R1. R2 and R4 preferably include a cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl; an aryl such as phenyl and naphthyl; and a heterocyclic ring, 3- to 7-membered, including a nitrogen or one or two oxygen atoms, either monocyclic or a condenced ring, saturated or unsaturated. Phenyl, unsubstituted, is most preferable. m and p are preferably 1 or 2 and most preferably 2. The most important compound is defined by the formula (I) in which R1 is (d), n is 1 or 2, Z is (2), R2 is phenyl, pyridyl or 1,3-dioxolane-2-yl and m is 1 or 2. (d) may have a methoxy on the benzene ring. The compounds having the formula (I) can be produced by analogous chemical processes for production. The processes are shown below for the compounds having the formula (I') and also apply to the compounds having the formula (I) by substituting Z for X. When Z is (2), the compounds (I) can be produced in the same way as here. Production process D : When R 1 in the general formula (I) represents a monovalent group derived from a substituted or unsubstituted tetrahydrobenzoxazinone, the compound can be produced also by the following process: wherein U, ℓ, n and R 2 are as defined above. Namely, a salicylaldehyde derivative of the general formula (XI) is condensed with an amine of the general formula (VI) in a solvent such as methanol and the condensate is reduced with sodium borohydride to give a compound (XII). This compound is reacted with 1,1-carbonyldiimidazole in a solvent such as tetrahydrofuran to give a compound (XIII) which is one of the intended compounds. Production process E: When R 1 in the general formula (I) represents a group derived from a substituted or unsubstituted tetrahydrobenzoxazinedione, and R 2 represents a substituted or unsubstituted arylmethyl, furylmethyl or thienylmethyl group or the like, the compound can be produced also by the following process: wherein U, ℓ, n and R 2 are as defined above, and R 3 represents a protective group such as a methoxymethyl or methoxyethoxymethyl group. Namely, a salicylic acid derivative of the general formula (XIV) and an amine of the general formula (VI) are condensed with, for example, 1,1-carbonyldiimidazole in a solvent such as tetrahydrofuran, and the protective group is removed with an acid such as hydrochloric acid to form a compound (XV). This compound is reacted with 1,1-carbonyldiimidazole in a solvent such as tetrahydrofuran to give a compound (XVI) which is one of the intended compounds. Production process F : When R 1 in the general formula (I) represents a group derived from a substituted or unsubstituted tetrahydrobenzoxazinedione, and R 2 represents a cycloalkylmethyl, 1,3-dioxolan-2-ylmethyl or tetrahydrofurylmethyl group or the like, the compound can be produced also by the following process: wherein U, ℓ, n and R 2 are as defined above. Namely, a salicylic acid derivative of the general formula (XVII) and an amine of the general formula (VI) are condensed with, for example, 1,1-carbonyldiimidazole in a solvent such as tetrahydrofuran to give a compound (XVIII) and the protective group is removed therefrom by catalytic reduction conducted in the presence of Pd-C or the like in a solvent such as methanol. This compound is reacted with 1,1-carbonyldiimidazole in a solvent such as tetrahydrofuran to give a compound (XIX) which is one of the intended compounds. Production process H : When R 1 in the general formula (I) represents a group derived from a substituted or unsubstituted tetrahydrobenzoxazin-2-one or tetrahydrobenzoxazine-2,4-dione and the compound can be produced also by the following process: wherein U, ℓ, n and R 2 are as defined above and L represents a carbonyl or methylene group. Namely, a cyclic amide compound of the general formula (XXIV) is condensed with an alcohol of the general formula (XXV) in a solvent such as tetrahydrofuran in the presence of diethyl azodicarboxylate or diisopropyl azodicarboxylate and triphenylphosphine to give a compound (XXVI) which is one of the intended compounds. The compounds of the formula (I) or acid addition salts thereof produced as described above are effective for the treatment of various senile dementias, particularly Alzheimer's disease. The following results of pharmacological tests will illustrate the usefulness of the compounds of the general formula (I) and acid addition salts thereof. Experimental Example 1 Acetylcholine esteraze inhibition effect in vitro : The esterase activity was determined by using a mouse brain homogenate as the acetylcholine esterase source by the method of Ellmann et al . Acetylthiocholine as the substrate, the sample and DTNB were added to the mouse brain homogenate and they were incubated. A yellow product formed by the reaction of the produced thiocholine with DTNB was determined on the basis of a change in absorbance at 412 nm to determine the acetylcholine esterase activity. The acetylcholine esterase inhibiting activity of the sample was expressed in terms of 50% inhibiting concentration (IC 50 ). The results are given in Table 1. Compound (Ex. No.) AChE inhibiting activity IC 50 (nM) Compound (Ex. No.) AChE inhibiting activity IC 50 (nM) 1 0.03 35 1.85 2 4.94 36 1.17 3 8.52 37 2.97 4 7.93 38 0.70 5 49.5 39 7.79 6 4.86 40 1024.6 41 4.64 42 3.92 43 2.96 44 5.04 46 11.4 52 64.9 53 0.18 54 0.34 24 1.87 25 2.74 26 0.50 28 0.38 30 29.1 31 0.58 32 1.39 33 0.20 34 13.8 It is apparent from the above-described pharmacological experimental examples that the piperidine derivatives of the present invention have a patent acetylcholine esterase inhibiting effect. The cyclic amide derivatives obtained by the present invention have such features that the structure thereof is quite different from that of ordinary acetylcholine esterase inhibitors, that they have a patent acetylcholine esterase inhibiting effect, that the difference between the intended effect and adverse effect thereof is quite large, that the effect lasts for a long time, that they are quite stable compounds having a high water solubility, which is advantageous from the viewpoint of formulation, that their utilization in vivo is high, that they are substantially free from the first pass effect and that they have a high migration rate into the brain. Thus the object of the present invention is to provide new compounds effective for the treatment of various dementias and sequelae of cerebral blood vessel disorders, process for producing these compounds and a new medicine containing such a compound as the active ingredient. The compounds of the present invention are effective for the treatment, prevention, remission, improvement, etc. of senile dementias; particularly cerebral blood vessel disorders due to Alzheimer's presbyophrenia, cerebral stroke (cerebral hemorrhage or cerebral infarction), arteriosclerosis and an external wound of the head; and inattentiveness, disturbance of speech, weakened volition, emotional disorder, inability to fix, hallucination-delusion state and behavior changes owing to sequelae of cerebritis and cerebral palsy. The compounds of the present invention having a potent, highly selective anticholine esterase inhibiting effect are useful as a medicine having such an effect. The compounds of the present invention are effective for the treatment of Alzheimer's presbyophrenia as well as Huntington's chorea, Pick's disease and tardive dyskinesia. When the compounds of the present invention are used as a medicine for such a disease, they are given orally or parenterally. Usually, they are given by parenteral administration such as intravenous, subcutaneous or intramuscular injection or in the form of suppositories or sublingual tablets. The dose of the compounds is not particularly limited, since it varies depending on the symptoms; age, sex, body weight and sensitivity of the patient; medication; period and intervals of the administration, properties, composition and kind of the preparation; and kind of the active ingredient. Usually, however, they are given in an amount of about 0.1 to 300 mg, preferably about 1 to 100 mg, per day (1 to 4 times a day). The compounds of the present invention are formulated into injections, suppositories, sublingual tablets, tablets or capsules by an ordinary method employed in the technical field of the formulation. The injections are prepared by adding, if necessary, a pH adjustor, buffering agent, suspending agent, solubilizer, stabilizer, isotonizing agent and preservative to the active ingredient and they are formulated into the intravenous, subcutaneous or intramuscular injection. If necessary, they can be freeze-dried by an ordinary method. Examples of the suspending agents include methylcellulose, Polysorbate 80, hydroxyethylcellulose, acacia, tragacanth powder, sodium carboxymethylcellulose and polyoxyethylene sorbitan monolaurate. Examples of the solubilizers include polyoxyethylene-hardened castor oil, Polysorbate 80, nicotinamide, polyoxyethylene sorbitan monolaurate, macrogol and ethyl esters of castor oil fatty acids. Examples of the stabilizers include sodium sulfite, sodium metasulfite and ethers. Examples of the preservatives include methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, sorbic acid, phenol, cresol and chlorocresol. [Examples] The following Examples will further illustrate the present invention, which by no means limit the technical range of the present invention. Example 1 3-[2-(1-Benzyl-4-piperidyl)ethyl]-5-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one hydrochloride: 10 ml of methanol was added to 1.87 g of 1-benzyl-4-(2-aminoethyl)piperidine to give a solution and a solution of 0.53 g of 6-methoxysalicylaldehyde in 10 ml of methanol was added thereto. The mixture was stirred at room temperature for 30 min and then cooled with ice. Sodium borohydride was added thereto in small portions to conduct reduction. The solvent was distilled off and water was added to the residue. After extraction with ethyl acetate followed by drying over magnesium sulfate, the solvent was distilled off. An oily product thus obtained was dissolved in 50 ml of tetrahydrofuran and 2.77 g of N,N'-carbonyldiimidazole was added thereto. The mixture was heated under reflux for 1 h. The solvent was distilled off and an oily substance thus obtained was purified by silica gel column chromatography. The product was converted into its hydrochloride by an ordinary method to give 0.31 g of the intended compound in a colorless, amorphous form. Melting point: amorphous Molecular formula: C 23 H 28 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 1.20 ∼ 2.12 (9H, m), 2.84 (2H, bd), 3.37 ∼ 3.54 (4H, m), 3.80 (3H, s), 4.29 (2H, s), 6.54 (1H, q, J = 2.1Hz, 8.2Hz), 7.04 ∼ 7.18 (7H, m) MS: (M+1 + ) = 381 Example 2 3-[2-(1-Benzyl-4-piperidyl)ethyl]-2H-3,4-dihydro-1,3-benzoxazin-2-one hydrochloride : 6 ml of methanol was added to 0.954 g of 1-benzyl-4-(2-aminoethyl)piperidine to obtain a solution and a solution of 0.53 g of salicylaldehyde in 6 ml of methanol was added thereto. The mixture was stirred at room temperature for 30 min and then cooled with ice. Sodium borohydride was added thereto in small portions to conduct reduction. The solvent was distilled off and water was added to the residue. After extraction with ethyl acetate followed by drying over magnesium sulfate, the solvent was distilled off. An oily product thus obtained was dissolved in 15 ml of acetonitrile and 2.58 g of N,N'-carbonyldiimidazole was added thereto. The mixture was heated under reflux for 1 h. The solvent was distilled off and an oily substrate thus obtained was purified by silica gel column chromatography. The product was converted into its hydrochloride by an ordinary method to give 0.68 g of the intended compound in a colorless, amorphous form. Melting point: 209.8 to 210°C Molecular formula: C 22 H 26 N 2 O 2 ·HCl NMR(CDCl 3 )δ: 1.24 ∼ 2.08 (9H, m), 2.83 (2H, bd), 3.45 (2H, s), 3.46 (2H, t, J = 7.5Hz), 4.38 (2H, s), 6.89 ∼ 7.34 (9H, m) MS: (M+1 + ) = 351 Example 3 3-[2-(1-Benzyl-4-piperidyl)ethyl]-2H-3,4-dihydro-1,3-benzoxazine-2,4-dione hydrochloride : 2.15 g of 4-[2-(2-hydroxybenzoylamino)ethyl]-1-benzylpiperidine was dissolved in 70 ml of tetrahydrofuran and 2.06 g of N,N'-carbonyldiimidazole was added thereto. The mixture was heated under reflux for 24 h. The solvent was distilled off and an oily substance thus obtained was purified by silica gel column chromatography. The product was converted into its hydrochloride by an ordinary method to give 2.14 g of the intended compound in a colorless, amorphous form. Melting point: 225.3 to 227.1°C (decomp.) Molecular formula: C 22 H 24 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 1.24 ∼ 2.19 (9H, m), 2.86 (2H, bd), 3.46 (2H, s), 4.02 (2H, t, J = 7.5Hz), 7.14 ∼ 7.36 (7H, m), 7.59 (1H, q, J = 1.8Hz, 8.0Hz), 8.00 (1H, q, J = 1.8Hz, 8.0Hz) MS: (M+1 1 ) = 365 Example 4 3-{2-[1-(4-Pyridylmethyl)-4-piperidyl]ethyl}-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one dihydrochloride: 10 ml of methanol was added to 0.83 g of 1-(4-pyridylmethyl)-4-(2-aminoethyl)piperidine to give a solution and a solution of 0.63 g of 5-methoxysalicylaldehyde in 5 ml of methanol was added thereto. The mixture was stirred at room temperature for 30 min and then cooled with ice. Sodium borohydride was added thereto in small portions to conduct reduction. The solvent was distilled off and water was added to the residue. After extraction with ethyl acetate followed by drying over magnesium sulfate, the solvent was distilled off. An oily product thus obtained was dissolved in 20 ml of acetonitrile and 2.28 g of N,N'-carbonyldiimidazole was added thereto. The mixture was heated under reflux for 4 h. The solvent was distilled off and an oily substance thus obtained was purified by silica gel column chromatography. The product was converted into its hydrochloride by an ordinary method and recrystallized from methanol/ether to give 0.35 g of the intended compound in the form of colorless, needle-like crystals. Melting point: 132.2 to 132.8°C (decomp.) Molecular formula: C 22 H 27 N 3 O 3 ·2HCl NMR(CDCl 3 )δ: 1.20 ∼ 2.13 (9H, m), 2.82 (2H, bd), 3.46 (2H, s), 3.48 (2H, t, J = 7.5Hz), 3.75 (3H, s), 4.18 (2H, s), 6.58 (1H, dd, J = 2.8Hz, 8.5Hz), 6.79 (1H, d, J = 2.8Hz), 6.92 (1H, d, J = 8.5Hz), 7.23 (2H, d, J = 6.2Hz), 8.48 (2H, d, J = 6.2Hz) MS: (M+1 + ) = 382 Example 5 3-{2-[1-(1,3-Dioxolan-2-ylmethyl)-4-piperidine]ethyl}-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one hydrochloride : 0.70 g of 5-methoxysalicylaldehyde was dissolved in 10 ml of methanol and a solution of 1.28 g of 1-(1,3-dioxolan-2-ylmethyl)-4-(2-aminoethyl)piperidine in 10 ml of methanol was added thereto. The mixture was stirred at room temperature for 1 h and then sodium borohydride was added thereto under cooling with ice until yellow color disappeared. The reaction mixture was concentrated under reduced pressure and 150 ml of a saturated aqueous sodium hydrogen carbonate solution was added thereto. After extraction with 100 ml of methylene chloride twice followed by washing with 150 ml of an aqueous sodium chloride solution or brine and drying over magnesium sulfate, the product was concentrated under reduced pressure. An oily product thus obtained was dissolved in 100 ml of acetonitrile and 2.98 g of N,N'-carbonyldiimidazole was added thereto. The mixture was heated under reflux for 3 h and then left to cool to room temperature. After concentration under reduced pressure, 200 ml of ethyl acetate was added to the residue, which was washed with 200 ml of a saturated aqueous sodium hydrogen carbonate solution and then with 200 ml of a saturated aqueous sodium chloride solution. After drying over magnesium sulfate followed by concentration under reduced pressure, the residue was purified by silica gel column chromatography (methylene chloride : methanol = 100 : 1). A white solid thus obtained was recrystallized from ethyl acetate/hexane to give 1.30 g of white crystals. The product was converted into hydrochloride thereof to given 1.43 g (yield: 75%) of the intended compound in amorphous form. Melting point: amorphous Molecular formula: C 22 H 28 N 2 O 5 ·HCl NMR(CDCl 3 )δ: 1.30 ∼ 1.41 (3H, m), 1.60 (2H, dd), 1.72 (2H, d), 2.06 (2H, t), 2.56 (2H, d), 2.98 (2H, d), 3.49 (2H, dd), 3.78 (3H, s), 3.82 ∼ 4.00 (4H, m), 4.41 (2H, s), 5.00 (1H, t), 6.60 (1H, d), 6.79 (1H, dd), 6.95 (1H, d) MS: (M+1 + ) = 377 Example 6 3-[2-(1-Cyclopentylmethyl-4-piperidyl)ethyl]-6-methoxy-2H-3,4-dihydro-1,3-benzoxazine-2,4-dione hydrochloride: 0.91 g of 4-[2-(2-benzyloxy-5-methoxybenzoylamino)ethyl]-1-cyclopentylmethylpiperidine was dissolved in 50 ml of methanol and 0.07 g of 10% Pd-C was added thereto. The mixture was stirred at room temperature in a hydrogen atmosphere for 1 h. The used Pd-C was removed by filtration and the solvent was distilled off to give a light yellow oily substance. 30 ml of tetrahydrofuran was added thereto to give a solution and 0.65 g of N,N'-carbonyldiimidazole was added thereto. The mixture was heated under reflux for 13 h. The solvent was distilled off and an oily substance thus obtained was purified by silica gel column chromatography. It was converted into hydrochloride thereof in an ordinary manner and recrystallized from methanol/ether to give 0.39 g of the intended compound in the form of colorless needle-like crystals. Melting point: 213.5 to 214.1°C Molecular formula: C 22 H 30 N 2 O 4 ·HCl NMR(CDCl 3 )δ: 1.17 ∼ 1.21 (2H, m), 1.36 ∼ 1.39 (3H, m), 1.50 ∼ 1.68 (6H, m), 1.74 ∼ 1.79 (4H, m), 1.97 (2H, t, J = 10.8Hz), 2.08 (1H, septet, J = 7.6Hz), 2.31 (1H, d, J = 7.2Hz), 2.97 (2H, bd), 3.87 (3H, s), 4.06 (2H, m), 7.19 (1H, d, J = 9.2Hz), 7.25 (1H, dd, J = 3.2Hz, 9.2Hz), 7.45 (1H, d, J = 3.2Hz) MS: (M+1 + ) = 387 compound in the form of a light yellow amorphous substance. Melting point: amorphous Molecular formula: C 20 H 27 N 3 O 5 ·HCl NMR(CDCl 3 )δ: 1.36 (3H, bs), 1.59 ∼ 1.64 (2H, m), 1.76 (2H, bd), 2.05 (2H, bt), 2.53 (2H, d, J = 4.6Hz), 2.98 (2H, bd), 3.80 ∼ 3.83 (2H, m), 3.83 (3H, s), 3.91 ∼ 3.93 (2H, m), 4.08 (2H, bt), 4.98 (1H, t, J = 4.6Hz), 7.04 (1H, d, J = 8.8Hz), 7.18 (1H, q, J = 2.8Hz, 8.8Hz), 7.49 (1H, d, J = 2.8Hz), 11.05 (1H, bs) MS: (M+H + ) = 390 Examples 18 to 80 The following compounds were produced in the same manner as that of Examples 1 to 17. The Arabic numerals refer to Example Numbers. Melting point: 217.6 ∼ 218.8°C Molecular formula: C 23 H 28 N 2 O 2 ·HCl NMR(CDCl 3 )δ: 1.16 ∼ 2.04 (11H, m), 2.83 (2H, bd), 2.40 (2H, t, J = 7.2Hz), 2.43 (2H, s), 4.39 (2H, s), 6.88 ∼ 7.35 (9H, m) MS: M + = 364 (DI-EI) Melting point: 209.5 ∼ 210.7°C Molecular formula: C 23 H 28 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 1.22 ∼ 2.12 (9H, m), 2.89 (2H, bd), 3.48 (2H, t, J = 7.3Hz), 3.51 (2H, s), 3.76 (3H, s), 4.35(2H, s), 6.59(1H, dd, J = 2.8Hz, 13.1Hz), 6.94 (1H, d, J = 13.1Hz), 7.18 ∼ 7.38 (6H, m) MS: (M+1 + ) = 381 (FAB) Melting point: amorphous Molecular formula: C 23 H 28 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 1.16 ∼ 2.12 (9H, m), 2.85 (2h, bd), 3.38 ∼ 3.55 (4H, m), 3.83 (3H, s), 4.37 (2H, s), 6.54 ∼ 7.00 (3H, m), 7.24 (5H, s) MS: (M+1 + ) = 381 (FAB) Melting point: 209.8 ∼ 210.9°C (decomp.) Molecular formula: C 23 H 28 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 1,19 ∼ 2.11 (9H, m), 2.87 (2H, bd), 3.43 (2H, t, J = 7.5Hz), 3.48 (2H, s), 3.94 (3H, s), 4.35 (2H, s), 6.60 (1H, dd, J = 2.6Hz, 9.8Hz), 6.78 (1H, d, J = 2.6Hz), 6.91 (1H, d, J = 9.8Hz), 7.24 (5H, s) MS: (M+1 + ) = 381 (FAB) Melting point: amorphous Molecular formula: C 24 H 30 N 2 O 4 ·HCl NMR(CDCl 3 )δ: 1.24 ∼ 2.12 (9H, m), 2.88 (2H, bd), 3.38 ∼ 3.56 (4H, m), 3.75 (3H, s), 3.78 (3H, s), 4.24 (2H, s), 6.15 (1H, bs), 7.20 ∼ 7.30 (6H, bs) MS: (M+1 + ) = 411 (FAB) Melting point: 220.5 ∼ 221.8°C (decomp.) Molecular formula: C 22 H 24 Cl 2 N 2 O 2 ·HCl NMR(CDCl 3 )δ: 1.24 ∼ 2.20 (9H, m), 2.95 (2H, bd), 3.36 ∼ 3.56 (4H, m), 4.38 (2H, s), 6.96 (1H, bs), 7.29 (6H, bs) MS: (M+1 + ) = 419 (FAB) Melting point: amorphous Molecular formula: C 21 H 23 Cl 2 N 3 O 2 ·2HCl NMR(CDCl 3 )δ: 1.20 ∼ 1.12 (9H, m), 2.78 (2H, bd), 3.36 ∼ 3.53 (4H, m), 4.36 (2H, s), 6.92 (1H, d, J = 2.3Hz), 7.08 ∼ 7.28 (3H, m), 8.41 (2H, d, J = 8.5Hz) MS: (M+1 + ) = 420 (FAB) Melting point: 231.1 ∼ 232.3°C (decomp.) Molecular formula: C 22 H 25 N 3 O 4 ·HCl NMR(CDCl 3 )δ: 1.16 ∼ 2.09 (9H, m), 2.84 (2H, bd), 2.40 ∼ 2.56 (4H, m), 4.47 (2H, s), 7.06 (1H, d, J = 9.3Hz), 7.23 (5H, s), 7.97 (1H, d, J = 2.6Hz), 8.08 (1H, dd, J = 2.6Hz, 9.3Hz) MS: (M+1 + ) = 396 (FAB) Melting point: 22.53 ∼ 227.1°C (decomp.) Molecular formula: C 22 H 25 ClN 2 O 2 ·HCl NMR(CDCl 3 )δ: 1.20 ∼ 2.08 (9H, m), 2.83 (2H, bd), 3.35 ∼ 3.52 (4H, m), 4.33 (2H, s), 6.85 (1H, d, J = 9.0Hz), 7.04 (1H, dd, J = 2.8Hz, 9.0Hz), 7.22 (6H, bs) MS: (M+1 + ) = 385 (FAB) Melting point: amorphous Molecular formula: C 24 H 30 N 2 O 4 ·HCl NMR(CDCl 3 )δ: 1.16 ∼ 2.12 (9H, m), 2.84 (2H, bs), 3.36 ∼ 3.52 (4H, m), 3.81 (6H, s), 4.31 (2H, s), 6.47 (1H, d, J = 1.8Hz), 7.22 (6H, bs) MS: (M+1 + ) = 411 (FAB) Melting point: 189.1 ∼ 189.8°C Molecular formula: C 21 H 24 N 4 O 4 ·2HCl NMR(CDCl 3 )δ: 1.21 ∼ 2.15 (9H, m), 2.82 (2H, bd), 3.42 ∼ 3.62 (4H, m), 4.56 (2H, s), 7.06 (1H, d, J = 8.2Hz), 7.24 (2H, d, J = 6.2Hz), 8.03 ∼ 8.15 (2H, m), 8.44 (2H, d, J = 6.2Hz) MS: (M+1 + ) = 397 (FAB) Melting point: amorphous Molecular formula: C 22 H 27 N 3 O 2 ·2HCl NMR(CDCl 3 )δ: 1.16 ∼ 2.07 (9H, m), 2.82 (2H, bd), 3.32 ∼ 3.48 (4H, m), 3.92 (2H, bs), 4.24 (2H, s), 6.30 (1H, d, J = 2.3Hz), 6.46 (1H, q, J = 2.3Hz, 8.7Hz), 6.72 (1H, d, J = 8.7Hz), 7.22 (5H, bs) MS: (M+1 + ) = 366 (FAB) Melting point: amorphous Molecular formula: C 24 H 29 N 3 O 3 ·HCl NMR(CDCl 3 )δ: 1.16 ∼ 2.12 (9H, m), 2.14 (3H, s), 2.84 (2H, bd), 3.45 (4H, bs), 4.33 (2H, s), 6.78 (1H, d, J = 9.5Hz), 7.14 ∼ 7.28 (6H, m), 7.63 (1H, bs), 9.00 (1H, s) MS: (M+1 + ) = 408 (FAB) Melting point: amorphous Molecular formula: C 23 H 26 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 1,24 ∼ 2.12 (9H, m), 2.40 (3H, s), 2.86 (2H, bd), 3.47 (2H, s), 4.00 (2H, bt), 7.00 ∼ 7.44 (7H, m), 7.76 (1H, bs) MS: (M+1 + ) = 379 (FAB) Melting point: 195.1 ∼ 195.8°C Molecular formula: C 23 H 26 N 2 O 4 ·HCl NMR(CDCl 3 )δ: 1.34 (3H, bs), 1.65 (2H, bs), 1.74 (2H, bs), 1.95 (2H, bt), 2.87 (2H, bd), 3.48 (2H, s), 3.86 (3H, s), 4.05 (2H, dt, J = 2.0Hz, 7.2Hz), 7.19 (1H, d, J = 9.4Hz), 7.24 (1H, q, J = 3.0Hz, 9.4Hz), 7.31 (5H, bs) 7.45 (1H, d, J=3.0Hz) MS: (M+1 + ) = 395 (FAB) Melting point: 199.5 ∼ 200.4°C Molecular formula: C 22 H 23 FN 2 O 3 ·HCl NMR(CDCl 3 )δ: 1.34 (3H, bs), 1.63 ∼ 1.66 (2H, m), 1.73 ∼ 1.77 (2H, m), 1.95 (2H, bt), 2.86 (2H, bd), 3.48 (2H, s), 4.04 (2H, dt, J = 4.0Hz, 5.2Hz), 7.23 ∼ 7.28 (6H, m), 7.37 ∼ 7.42 (1H, m), 7.71 ∼ 7.73 (1H, m) MS: (M+1 + ) = 383 (FAB) Melting point: 209.4 ∼ 210.6°C (decomp.) Molecular formula: C 19 N 23 FN 2 O 5 ·HCl NMR(CDCl 3 )δ: 1.34 ∼ 1.41 (3H, m), 1.60 ∼ 1.66 (2H, bq), 1.73 ∼ 1.76 (2H, bd), 2.06 (2H, t, J = 11.2Hz), 2.55 (2H, d, J = 4.4Hz), 2.98 (2H, bd), 3.83 ∼ 3.86 (2H, m), 3.94 ∼ 3.98 (2H, m), 4.02 ∼ 4.06 (2H, m), 4.99 (1H, t, J = 4.4Hz), 7.25 - 7.28 (1H, m), 7.37 ∼ 7.42 (1H, m), 7.72 (1H, q, J = 2.6Hz, 7.2Hz) MS: (M+1 + ) = 379 (FAB) Melting point: 210.5 ∼ 211.4°C (decomp.) Molecular formula: C 22 H 32 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 1.15 ∼ 1.20 (2H, m), 1.25 ∼ 1.38 (3H, m), 1.51 ∼ 1.60 (6H, m), 1.72 ∼ 1.78 (4H, m), 1.93 (2H, t, J = 9. 6Hz), 2.06 (1H, m), 2.25 (2H, dd, J = 2.0Hz, 7.2Hz), 2.91 (2H, bd), 3.45 ∼ 3.49 (2H, m), 3.75 (3H, s), 4.38 (2H, s), 6.58 (1H, s), 6.76 (1H, d, J = 10.0Hz), 6.91 (1H, d, J = 10.0Hz) MS: (M+1 + ) = 373 (FAB) Melting point: 206.5 ∼ 207.8°C Molecular formula: C 23 H 34 N 2 O 3 ·HCl NMR(CDCl 3 )δ: 0.81 ∼ 0.89 (2H, m), 1.09 ∼ 1.23 (3H, m), 1.23 ∼ 1.35 (2H, m), 1.46 (1H, m), 1.54 ∼ 1.76 (10H, m) 1.84 (2H, bt), 2.08 (2H, d, J = 7.2Hz), 2.84 (2H, bd), 3.49 (2H, m), 3.76 (3H, s), 4.41 (2H, s), 6.60 (1H, d, J = 2.8Hz), 6.78 (1H, dd, J = 2.8 Hz, 8.8Hz), 6.92 (1H, d, J = 8.8Hz) MS: (M+1 + ) = 387 (FAB) Melting point: 205.9 ∼ 207.2°C (decomp.) Molecular formula: C 23 H 32 N 2 O 4 ·HCl NMR(CDCl 3 )δ: 0.84 ∼ 0.92 (2H, m), 1.15 ∼ 1.25 (3H, m), 1.36 ∼ 1.42 (2H, m), 1.51 (1H, m), 1.63 ∼ 1.78 (10H, m), 1.93 (2H, t, J = 10.6Hz), 2.15 (2H, d, J = 7.2Hz), 2.91 (2H, bd), 3.87 (3H, s), 4.06 (2H, m), 7.19 (1H, d, J = 8.8Hz), 7.25 (1H, dd, J = 2.8Hz, 8.8Hz), 7.45 (1H, d, J = 2.8Hz) MS: (M+1 + ) = 401 (FAB) Melting point: 119.5 ∼ 120.8°C Molecular formula: C 21 H 26 N 2 O 4 ·C 4 H 4 O 4 NMR(CDCl 3 )δ: 1.28 ∼ 1.33 (3H, m), 1.58 ∼ 1.62 (2H, m), 1.63 ∼ 1.75 (2H, m), 1.93 (2H, bt), 2.90 (2H, bd), 3.37 (2H, s), 3.50 (2H, m), 3.78 (3H, s), 4.41 (2H, s), 6.38 (1H, dd, J = 0.8Hz, 1.6Hz), 6.60 (1H, d, J = 2.8Hz), 6.79 (1H, dd, J = 2.8Hz, 8.8Hz), 6.95 (1H, d, J = 8.8Hz), 7.32 (1H, dd, J = 0.8Hz, 1.6Hz), 7.37(1H, t, J = 1.6Hz) MS: (M+1 + ) = 371 (FAB) Melting point: 155.3 ∼ 156.0°C Molecular formula: C 21 H 24 N 2 O 5 ·C 4 H 4 O 4 NMR(CDCl 3 )δ: 1.30 ∼ 1.43 (3H, m), 1.62 ∼ 1.68 (2H, m), 1.76 ∼ 1.80 (2H, m), 1.99 (2H, bt), 2.89 (2H, bd), 3.52 (2H, s), 3.87 (3H, s), 4.04 (2H), m), 6.18 (1H, d, J = 3.2Hz), 6.31 (1H, dd, J = 3.2Hz, 6.4Hz), 7.19 (1H, d, J = 8.8Hz), 7.20 ∼ 7.28 (2H, m), 7.36 ∼ 7.37 (1H, m), 7.45 (1H, d, J = 3.2Hz) MS: (M+1 + ) = 385 (FAB) Melting point: 162.9 ∼ 163.6°C Molecular formula: C 21 H 24 N 2 O 5 ·C 4 H 4 O 4 NMR(CDCl 3 ) δ: 1.30 ∼ 1.38 (3H, m), 1.62 ∼ 1.66 (2H, m), 1.77 ∼ 1.79 (2H, m), 1.94 (2H, bt), 1.90 (2H, bd), 3.37 (2H, s), 3.87 (3H, s), 4.05 (2H, m), 6.38 (1H, bs), 7.19 (1H, d, J = 9.2Hz), 7.24 (1H, dd, J = 2.8Hz, 9.2Hz), 7.32(1H, bs), 7.37 (1H, bs), 7.44 (1H, d, J = 2.8Hz) MS: (M+1 + ) = 385 (FAB) Melting point: 113.3 ∼ 113.8°C Molecular formula: C 21 H 26 N 2 O 4 ·C 4 H 4 O 4 NMR(CDCl 3 )δ: 1.31 ∼ 1.38 (3H, m), 1.56 ∼ 1.62 (2H, m), 1.73 (2H, bd), 1.97 (2H, t, J = 11.0Hz), 2.88 (2H, bd), 3.48 (2H, m), 3.51 (2H, s), 3.77 (3H, s), 4.40 (2H, s), 6.18 (1H, d, J = 3.2Hz), 6.30 (1H, dd, J = 2.0Hz, 3.2Hz), 6.59 (1H, d, J = 2.8Hz), 6.79 (1H, dd, J = 2.8Hz, 8.8Hz), 6.93 (1H, d, J = 8.8Hz), 7.36 (1H, d, J = 2.0Hz) MS: (M+1 + ) = 371 (FAB) Melting point: 178.5 ∼ 179.1°C Molecular formula: C 21 H 26 N 2 O 3 S·C 4 H 4 O 4 NMR(CDCl 3 )δ: 1.28 ∼ 1.38 (3H, m), 1.57 ∼ 1.61 (2H, m), 1.71 ∼ 1.73 (2H, m), 1.98 (2H, bt), 2.91 (2H, bd), 3.48 (2H, m), 3.70 (2H, s), 3.76 (3H, s), 4.39 (2H, s), 6.59 (1H, d, J = 1.2Hz), 6.78 (1H, dd, J = 1.2Hz, 8.8Hz), 6.88 ∼ 6.94 (3H, m), 7.20 (1H, d, J = 4.8Hz) MS: M + = 386 (DI-EI) Melting point: 188.3 ∼ 189.2°C Molecular formula: C 21 H 26 N 2 O 3 S·C 4 H 4 O 4 NMR(CDCl 3 )δ: 1.24 ∼ 1.36 (3H, m), 1.61 ∼ 1.63 (2H, m), 1.72 ∼ 1.74 (2H, m), 1.92 (2H, bt), 2.89 (2H, bd), 3.48 ∼ 3.53 (2H, m), 3.53 (2H, s), 3.78 (3H, s), 4.41 (2H, s), 6.60 (1H, d, J = 2.8Hz), 6.79 (1H; dd, J = 2.8Hz, 8.8Hz), 6.96 (1H, d, J = 8.8Hz), 7.05 (1H, dd, J = 0.8Hz, 5.0Hz), 7.11 (1H, bs), 7.25 ∼ 7.27 (1H, bs) MS: M + = 386 (DI-ES) Melting point: amorphous Molecular formula: C 20 H 28 N 2 O 5 ·HCl NMR(CDCl 3 )δ: 1.26 ∼ 1.43 (3H, m), 1.59 ∼ 1.67 (2H, m), 1.74 (2H, bd), 2.08 (2H, t), 2.56 (2H, d), 3.00 (2H, d), 3.52 (2H, t), 3.83 ∼ 3.90 (2H, m), 3.86 (3H, s), 3.92 ∼ 4.00 (2H, m), 4.37 (2H, s), 5.00 (1H, dd), 6.63 (2H, dd), 7.21 (1H, t) MS: (M+1 + ) = 377 (FAB) Melting point: 194 - 195°C Molecular formula: C 23 H 25 N 2 O 4 F·HCl NMR(CDCl 3 )δ: 1.30 ∼ 1.41 (3H, m), 1.62 ∼ 1.70 (2H, m), 1.76 (2H, bd), 1.97 (2H, t), 1.87 (2H, d), 3.48 (2H, s), 3.88 (3H, s), 4.07 (2H, dd), 6.92 (1H, t), 7.03 ∼ 7.10 (2H, m), 7.18 ∼ 7.29 (3H, m), 7.46 (1H, d) MS: (M+1 + ) = 413 (FAB) Melting point: 229 ∼ 230°C Molecular formula: C 23 H 27 N 2 O 3 F·HCl NMR(CDCl 3 )δ: 1.22 ∼ 1.39 (3H, m), 1.58 ∼ 1.65 (2H, m), 1.72 (2H, bd), 1.96 (2H, t), 2.84 (2H, d), 3.46 (2H, s), 3.50 (2H, t), 3.78 (3H, s), 4.41 (2H, s), 6.60 (1H, d), 6.79 (1H, dd), 6.90 ∼ 6.98 (2H, m), 7.02 ∼ 7.10 (2H, m), 7.20 ∼ 7.30 (1H, m) MS: (M+1 + ) = 399 (FAB) Melting point: 100 ∼ 101°C Molecular formula: C 20 H 28 N 2 O 5 NMR(CDCl 3 )δ: 1.30 ∼ 1.41 (3H, m), 1.60 (2H, dd), 1.72 (2H, d), 2.06 (2H, t), 2.56 (2H, d), 2.98 (2H, d), 3.49 (2H, dd), 3.78 (3H, s), 3.82 ∼ 4.00 (4H, m), 4.41 (2H, s), 5.00 (1H, t), 6.60 (1H, d), 6.79 (1H, dd), 6.95 (1H, d) MS: (M+1 + ) = 377 (FAB) Melting point: 243 ∼ 244°C (decomp.) Molecular formula: C 21 H 24 N 2 O 2 ·HCl NMR(CDCl 3 )δ: 1.24 ∼ 2.48 (7H, m), 2.72 ∼ 3.02 (2H, m), 3.32 (2H, d), 3.48 (2H, s), 4.42 (2H, s), 6.68 ∼ 7.40 (9H, m) MS: M + = 336 (FD) Melting point: 264 ∼ 265°C (decomp.) Molecular formula: C 21 H 23 N 2 O 2 Br·HCl NMR(CDCl 3 )δ: 1.24 ∼ 2.52 (7H, m), 2.80 ∼ 3.10 (2H, m), 3.31 (2H, d), 3.64 (2H, s), 4.38 (2H, s), 6.70 ∼ 7.40 (8H, m) MS: M + +1 = 416 (FD) M + -1 = 414 (FD) Melting point: 116 ∼ 117°C Molecular formula: C 20 H 21 N 2 O 2 Br·HCl NMR(CDCl 3 )δ: 1.58 ∼ 2.48 (6H, m), 2.84 ∼ 3.18 (2H, m), 3.51 (2H, s), 4.04 ∼ 4.30 (1H, m), 4.32 (2H, s), 6.84 (1H, d), 7.14 ∼ 7.40 (7H, m) MS: M + +1 = 402 (FD) M + -1 = 400 (FD) Ex. No. 76 Mol. Form. C 21 H 28 N 2 O 5 ·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.30 ∼ 1.60 (7H, m), 1.61 ∼ 1.68 (2H, m), 1.75 ∼ 1.79 (2H, m), 1.82 ∼ 2.09 (2H, m), 1.94 ∼ 2.08 (3H, m), 2.41 ∼ 2.52 (2H, m), 2.99 ∼ 3.06 (2H, m), 3.87 (3H, s), 4.03 ∼ 4.08 (2H, m), 7.19 (1H, d, J = 9.0 Hz), 7.25 (1H, dd, J = 3.0 Hz, 9.0 Hz), 7.45 (1H, d, J = 3.0 Hz) MS (determn. method) M + = 389 (FAB) (M + 1 + ) M.P. (°C) 138.8 ∼ 139.2°C Mol. Form. C 21 H 30 N 2 O 4 ·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.30 ∼ 2.10 (13H, m), 2.18 ∼ 2.51 (2H, m), 3.01 (2H, bt), 3.49 (2H, m), 3.70 ∼ 3.68 (1H, m), 3.77 (3H, s), 3.82 ∼ 3.88 (1H, m), 4.01 ∼ 4.08 (1H, m), 4.41 (2H, s), 6.64 ∼ 6.84 (2H, m), 6.94 ∼ 6.96 (1H, m) MS (determn. method) M + = 375 (FAB) (M + 1 + ) M.P. (°C) 152.5 ∼ 152.8°C Mol. Form. C 22 H 28 N 2 O 4 NMR (δ, solv. CDCℓ 3 ) 1.31 ∼ 1.38 (3H, m), 1.58 ∼ 1.65 (4H, m), 1.86 ∼ 2.00 (2H, m), 2.01 (3H, s), 2.88 (2H, bd), 3.46 (2H, s), 3.50 (2H, bt), 3.78 (3H, s), 4.40 (2H, s), 6.60 (1H, d, J = 2.8 Hz), 6.72 (1H, d, J = 1.4 Hz), 6.79 (1H, dd, J = 2.8 Hz, 9.0 Hz), 6.95 (1H, d, J = 9.0 Hz), 7.28 (1H, d, J = 1.4 Hz) MS (determn. method) M + = 385 (FAB) (M + 1 + ) M.P. (°C) 171.8 ∼ 172.2°C Mol. Form. C 21 H 24 N 2 O 4 S·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.32 ∼ 1.38 (3H, m), 1.62 ∼ 1.66 (2H, m), 1.75 ∼ 1.79 (2H, m), 1.99 (2H, bt), 2.92 (2H, bd), 3,71 (2H, s), 3.87 (3H, s), 4.02 ∼ 4.05 (2H, m), 6.88 ∼ 6.90 (1H, m), 7.18 ∼ 7.26 (4H, m), 7.43 ∼ 7.46 (1H, m) MS (determn. method) M + = 401 (FAB) (M + 1 + ) M.P. (°C) 190.2 ∼ 190.8°C Mol. Form. C 21 H 24 N 2 O 4 S·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.33 ∼ 1.38 (3H, m), 1.62 ∼ 1.67 (2H, m), 1.75 ∼ 1.78 (2H, m), 1.95 (2H, bt), 2.89 (2H, bd), 3,52 (2H, s), 3.87 (3H, s), 4.04 ∼ 4.07 (2H, m), 7.05 (1H, d, J = 4.8 Hz), 7.10 (1H, bs), 7.19 (1H, d, J = 8.8 Hz), 7.23 ∼ 7.27 (2H, m), 7.45 (1H, d, J = 2.8 Hz) MS (determn. method) M + = 401 (FAB) (M + 1 + ) M.P. (°C) 197.2 ∼ 198.0°C Example 81 {(N-Benzyl-N-methyl)-5-aminopentyl}-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one fumarate : 10 ml of methanol was added to 1.62 g of N-benzyl-N-methyl-1,5-diaminopentane to prepare a solution, which was stirred at room temperature. 0.98 ml of 5-methoxysalicylaldehyde was added to the solution and the solution was stirred as such for 20 min. The reaction mixture was cooled with ice and sodium borohydride was added in small portions thereto until the reaction liquid turned pale yellow. After stirring at room temperature for additional 30 min, the solvent was distilled off. A saturated aqueous solution of sodium hydrogencarbonate and ethyl acetate were added thereto and the solution was thoroughly stirred. An organic layer thus formed was separated. The aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined together and washed with a saturated aqueous solution of common salt. After drying over magnesium sulfate, the solvent was distilled off. 30 ml of tetrahydrofuran was added to the residue to prepare a solution. 1.91 g of N,N-carbonyldiimidazole was added to the solution and the resulting solution was heated under reflux for 3 h. The solvent was distilled off. An oily product thus obtained was purified by silica gel column chromatography to give 1.44 g of a colorless oily product, which was dissolved in methanol. A solution of 0.45 g of fumaric acid in methanol was added thereto. The solvent was distilled off to give 1.89 g of the title compound in the form of a colorless amorphous substance. Mol. Form. C 22 H 28 N 2 O 3 ·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.33 ∼ 1.41 (2H, m), 1.52 ∼ 1.70 (4H, m), 2.18 (3H, s), 2.36 (2H, t, J = 7.4 Hz), 3.45 (2H, t, J = 7.6 Hz), 3.47 (2H, s), 3.78 (3H, s), 4,41 (2H, s), 6.59 (1H, d, J = 2.8 Hz), 6.80 (1H, dd, J = 2.8 Hz, 8.8 Hz), 6.96 (1H, d, J = 8.8 Hz), 7.21 - 7.30 (5H, m) MS (determn. method) M + = 369 (FAB) (M + 1 + ) M.P. (°C) amorphous Example 82 {(N-Benzyl-N-methyl)-5-aminopentyl}-6-methoxy-2H-3,4-dihydro-1,3-benzoxazine-2,4-dione fumarate : 10 ml of tetrahydrofuran was added to 1.57 g of 2-methoxymethoxy-5-methoxybenzoic acid to prepare a solution. 1.91 g of N,N-carbonyldiimidazole was added to the solution and the resulting solution was stirred at room temperature for 15 min. A solution of 1.43 g of N-benzyl-N-methyl-1,5-diaminopentane in 5 ml of tetrahydrofuran was added thereto. After stirring for additional 13 h, the solvent was distilled off. The residue was cooled with ice and 8.3 ml of 5N hydrochloric acid and 5 ml of methanol were added thereto. The resulting solution was stirred at room temperature for 4.5 h. Methanol was distilled off under reduced pressure and the residue was cooled with ice. The pH of the reaction mixture was adjusted to 8 with sodium hydrogencarbonate. After extraction with ethyl acetate twice followed by washing with a saturated aqueous common salt solution and drying over magnesium sulfate, the solvent was distilled off. 30 ml of tetrahydrofuran was added thereto to prepare a solution. 2.24 g of N,N-carbonyldiimidazole was added to the solution and the resulting solution was heated under reflux for 16 hr. The solvent was distilled off. An oily product thus obtained was purified by silica gel column chromatography to give 2.16 g of a colorless oily product, which was dissolved in methanol. A solution of 0.66 g of fumaric acid in methanol was added to the solution. The solvent was distilled off to give 2.82 g of the title compound in the form of colorless amorphous substance. Mol. Form. C 22 H 26 N 2 O 4 ·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.40 (2H, broad quintet), 1.57 (2H, broad quintet), 1.72 (2H, broad quintet), 2.17 (3H, s), 2.37 (2H, t, J = 7.2 Hz), 3.47 (2H, s), 3.87 (3H, s), 4.03 (2H, t, J = 7.6 Hz), 7.18 ∼ 7.44 (8H, m) MS (determn. method) M + = 383 (FAB) (M + 1 + ) M.P. (°C) amorphous Examples 83 to 87 Compounds listed below were produced in the same manner as that of Examples 81 and 82. Mol. Form. C 18 H 26 N 2 O 5 ·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.49 ∼ 1.74 (4H, m), 2.32 (3H, s), 2.48 (2H, t, J = 7.2 Hz), 2.57 (2H, d, J = 4.5 Hz), 3.48 (2H, t, J = 7.6 Hz), 3.78 (3H, s), 3.81 ∼ 3.84 (2H, m), 3.86 ∼ 3.89 (2H, m), 4.43 (2H, s); 4.95 (1H, t, J = 4.5 Hz), 6.59 (1H, d, J = 3.2 Hz), 6.79 (1H, dd, J = 3.2 Hz, 8.8 Hz), 6.96 (1H, d, J = 8.8 Hz) MS (determn. method) M + = 351 (FAB) (M + 1 + ) M.P. (°C) amorphous Mol. Form. C 21 H 26 N 2 O 2 ·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.03 (3H, t, J = 7.2 Hz), 1.51 (2H, quintet, J = 7.6 Hz), 1.66 (2H, quintet, J = 7.6 Hz), 2.46 (2H, t, J = 7.2 Hz), 2.50 (2H, q, J = 7.5 Hz), 3.42 (2H, t, J = 7.6 Hz), 3.54 (2H, s), 4.39 (2H, s), 6.99 ∼ 7.11 (4H, m), 7.19 ∼ 7.32 (5H, m) MS (determn. method) M + = 339 (FAB) (M + 1 + ) M.P. (°C) amorphous Mol. Form. C 21 H 26 N 2 O 5 ·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.06 (3H, t, J = 7.2 Hz), 1.37 (2H, quintet, J = 7.2 Hz), 1.45 ∼ 1.58 (2H, m), 1.72 (2H, quintet, J = 7.5 Hz), 2.43 (2H, t, J = 7.6 Hz), 2.51 (2H, q, J = 7.2 Hz), 3.64 (2H, s), 3.87 (3H, s), 4.03 (2H, t, J = 7.5 Hz), 6.15 (1H, d, J = 3.0 Hz), 6.30 (1H, dd, J = 3.2 Hz, 2.0 Hz), 7.20 (1H, d, J = 8.8 Hz), 7.25 (1H, dd, J = 3.0 Hz, 8.8 Hz), 7.34 ∼ 7.36 (1H, m), 7.46 (1H, d, J = 3.2 Hz) MS (determn. method) M + = 387 (FAB) (M + 1 + ) M.P. (°C) amorphous Mol. Form. C 21 H 27 CℓN 2 O 2 S·C 4 H 4 O 4 NMR (δ, solv. CDCℓ 3 ) 1.05 (3H, t, J = 7.1 Hz), 1.33 ∼ 1.38 (4H, m), 1.45 ∼ 1.53 (2H, m), 1.62 ∼ 1.70 (2H, m), 2.43 (2H, t, J = 7.4 Hz), 2.53 (2H, q, J = 7.1 Hz), 3.45 (2H, t, J = 7.6 Hz), 3.79 (2H, s), 4.42 (2H, s), 6.80 ∼ 6.90 (3H, m), 7.07 ∼ 7.10 (1H, m), 7.18 ∼ 7.24 (2H, m) MS (determn. method) M + = 407 (FAB) (M + 1 + ) M.P. (°C) amorphous

Claims: Claims for the following Contracting States : AT, BE, CH, DE, DK, FR, GB, IT, LI, LU, NL, SE A cyclic amide derivative having the formula (I) or a pharmacologically acceptable salt thereof: R 1 -(CH 2 ) n -Z wherein R 1 is a group with ℓ being an integer of 1 to 4 and the U group(s) being independently of each other hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a halogen atom, an acyl group, an amino group or a nitro group; n is zero or an integer of 1 to 10 and Z is wherein R 2 and R 4 stand for cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl or phenyl substituted with fluorine, naphthyl, or a 3- to 7-membered monocyclic or condensed, saturated or unsaturated heterocyclic ring, including a nitrogen or one or two oxygen atoms, R 3 stands for a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and m and p stand for an integer of 1 to 6; with the proviso that the cyclic amide derivative is not a compound having one of the following formulae: or a salt thereof. The cyclic amide derivative as claimed in claim 1 or a pharmacologically acceptable salt thereof in which Z is (1). The cyclic amide derivative as claimed in claim 1 or a pharmacologically acceptable salt thereof in which Z is (1) and R 2 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxane-2-yl, n is 1 or 2 and m is 1 or 2. The cyclic amide derivative as claimed in claim 1 or a pharmacologically acceptable salt thereof in which Z is (1), R 2 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxane-2-yl, n is 1 or 2, m is 1 or 2 and the cyclic amide compound for R 1 is selected from the group consisting of 2H-3,4-dihydro-1,3-benzoxazin-2-one, 2H-3,4-dihydro-1,3-benzoxazin-2,4-dione. The cyclic amide derivative as claimed in claim 4 or a pharmacologically acceptable salt thereof in which R 1 is substituted with a C 1 -C 6 alkyl group or a C 1 -C 6 alkoxy group. The cyclic amide derivative as claimed in claim 4 or a pharmacologically acceptable salt thereof in which R 1 is substituted with methoxy. The cyclic amide derivative as claimed in claim 1 or a pharmacologically acceptable salt thereof in which Z is (2). The cyclic amide derivative as claimed in claim 1 or a pharmacologically acceptable salt thereof in which Z is (2), R 3 is a C 1 -C 6 alkyl group and R 4 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxane-2-yl. The cyclic amide derivative as claimed in claim 1 or a pharmacologically acceptable salt thereof, which derivative is selected from the group consisting of: 3-(2-(1-benzyl-4-piperidyl)ethyl)-5-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one, 3-(2-(1-(4-pyridylmethyl)-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one, 3-(2-(1-(1,3-dioxolan-2-yl-methyl)-4-piperidine)-ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one, 3-(2-(1-cyclopentylmethyl-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2,4-dione, 3-(2-(1-(1,3-dioxolan-2-yl-methyl)-4-piperidyl)-ethyl)-2H-3,4-dihydro-1,3-benzoxazin-2,4-dione, 3-(2-(1-benzyl-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one and 3-(2-(1-benzyl-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2,4-dione. A pharmaceutical composition comprising a pharmacologically effective amount of the cyclic amide derivative as defined in any of the preceding claims and a pharmacologically acceptable carrier. The use of any of the compounds according to claims 1 to 9 for the preparation of a medicament useful for preventing and treating diseases due to insufficiency of the central choline functions. Claims for the following Contracting States : ES, GR A process for producing a cyclic amide derivative having the formula (I) or a pharmacologically acceptable salt thereof: R 1 -(CH 2 ) n -Z wherein R 1 is a group with ℓ being an integer of 1 to 4 and the U group(s) being independently of each other hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a halogen atom, an acyl group, an amino group or a nitro group; n is zero or an integer of 1 to 10 and Z is wherein R 2 and R 4 stand for cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl or phenyl substituted with fluorine, naphthyl, or a 3- to 7-membered monocyclic or condensed, saturated or unsaturated heterocyclic ring, including a nitrogen or one or two oxygen atoms, R 3 stands for a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and m and p stand for an integer of 1 to 6; comprising the steps of (A) when R 1 in general formula (I) represents (c), condensing a salicylaldehyde derivative of general formula (XI) with an amine of general formula H 2 N-(CH 2 ) n -Z, reducing the condensate with sodium borohydride and reacting the intermediate with N,N-carbonyldiimidazole: wherein U, ℓ, n and Z are as defined above; or (B) when R 1 in general formula (I) represents (d), condensing a salicylic acid derivative of general formula (XIV) with an amine of general formula H 2 N-(CH 2 ) n -Z, removing the protective group with an acid, and reacting the resulting intermediate with N,N-carbonyldiimidazole: wherein R 3 is a protective group and U, ℓ, n and Z are as defined above; or (C) when R 1 in general formula (I) represents (d) and Z represents (1), condensing a salicylic acid derivative of general formula (XVII) and an amine of general formula H 2 N-(CH 2 ) n -Z, removing the protective benzyl group by catalytic reduction, and reacting the intermediate with N,N-carbonyldiimidazole: wherein U, ℓ, and n are as defined above; or (D) when Z in general formula (I) represents (1), condensing a cyclic amide compound of general formula (XXIV) with an alcohol of general formula HO-(CH 2 ) n -Z in the presence of diethyl azodicarboxylate or diisopropyl azodicarboxylate and triphenylphosphine: wherein U, ℓ, and n are as defined above and L represents a carbonyl or methylene group; with the proviso that the cyclic amide derivative is not a compound having one of the following formulae: or a salt thereof. The process as claimed in claim 1 wherein Z is (1). The process as claimed in claim 1 wherein Z is (1) and R 2 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxane-2-yl, n is 1 or 2 and m is 1 or 2. The process as claimed in claim 1 wherein Z is (1), R 2 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxane-2-yl, n is 1 or 2, m is 1 or 2 and the cyclic amide compound for R 1 is selected from the group consisting of 2H-3,4-dihydro-1,3-benzoxazin-2-one, 2H-3,4-dihydro-1,3-benzoxazin-2,4-dione. The process as claimed in claim 4 wherein R 1 is substituted with a C 1 -C 6 alkyl group or a C 1 -C 6 alkoxy group. The process as claimed in claim 4 wherein R 1 is substituted with methoxy. The process as claimed in claim 1 wherein Z is (2). The process as claimed in claim 1 wherein Z is (2), R 3 is a C 1 -C 6 alkyl group and R 4 is selected from phenyl, pyridyl, cyclopentyl and 1,3-dioxane-2-yl. The process as claimed in claim 1 wherein the cyclic amide derivative is selected from the group consisting of: 3-(2-(1-benzyl-4-piperidyl)ethyl)-5-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one, 3-(2-(1-(4-pyridylmethyl)-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one, 3-(2-(1-(1,3-dioxolan-2-yl-methyl)-4-piperidine)-ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one, 3-(2-(1-cyclopentylmethyl-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2,4-dione, 3-(2-(1-(1,3-dioxolan-2-yl-methyl)-4-piperidyl)-ethyl)-2H-3,4-dihydro-1,3-benzoxazin-2,4-dione, 3-(2-(1-benzyl-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2-one and 3-(2-(1-benzyl-4-piperidyl)ethyl)-6-methoxy-2H-3,4-dihydro-1,3-benzoxazin-2,4-dione. A process for preparing a pharmaceutical composition comprising admixing a a pharmacologically acceptable carrier to a pharmacologically effective amount of the cyclic amide derivative as defined in any of claims 1 to 9. The use of a cyclic amide derivative having the formula (I) or a pharmacologically acceptable salt thereof: R 1 -(CH 2 ) n -Z wherein R 1 is a group with ℓ being an integer of 1 to 4 and the U group(s) being independently of each other hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a halogen atom, an acyl group, an amino group or a nitro group; n is zero or an integer of 1 to 10 and Z is wherein R 2 and R 4 stand for cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl or phenyl substituted with fluorine, naphthyl, or a 3- to 7-membered monocyclic or condensed, saturated or unsaturated heterocyclic ring, including a nitrogen or one or two oxygen atoms, R 3 stands for a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and m and p stand for an integer of 1 to 6; with the proviso that the cyclic amide derivative is not a compound having one of the following formulae: or a salt thereof; for the preparation of a medicament useful for preventing and treating diseases due to insufficiency of the central choline functions.

Inventors: IIMURA YOUICHI, KARIBE NORIO, KOSASA TAKASHI, NAGATO SATOSHI, OGURA HIROO, SASAKI ATSUSHI, SUGIMOTO HACHIRO, UCHIKOSHI KUMI, YAMANISHI YOSHIHARU, YAMATSU KIYOMI, YONAGA MASAHIRO, IIMURA, YOUICHI, KARIBE, NORIO, KOSASA, TAKASHI, NAGATO, SATOSHI, OGURA, HIROO, SASAKI, ATSUSHI, SUGIMOTO, HACHIRO, UCHIKOSHI, KUMI, YAMANISHI, YOSHIHARU, YAMATSU, KIYOMI, YONAGA, MASAHIRO
Applicants: EISAI CO LTD, EISAI CO., LTD.
Application year: 1991
Main classification: C07D265
IPC codes: A61K31, C07D405, C07D413, C07D401, C07D495, C07D409, A61P25, A61P43, C07D265, A61P9, C07D471, C07D475, C12N9, C07D207, C07D487, C07D498, C07D263