Cyclopropachromen derivatives

Abstract: A cyclopropachromen derivative represented by formula (I): wherein n represents an integer of 2 to 5; R¹ and R² independently represent a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms, or alternatively R¹ and R² form together with the nitrogen atom, to which they are attached, a morpholino group, a thiomorpholino group, a pyrrolidinyl group, a piperidinyl group, a homopiperidinyl group, a piperazinyl group, a homopiperazinyl group, an N-alkylpiperazinyl group, N-alkylhomopiperazinyl group, an N-hydroxyalkylpiperazinyl group or a pyrrolidonyl group or alternatively R¹ and R² form together with the nitrogen atom to which they are attached, and further a carbon atom to which said nitrogen atom is bound, a pyrrolitidinyl group; A¹ and A² independently represent a hydrogen atom, a hydroxyl group, a halogen atom or an optionally substituted alkoxy group; B¹ and B² independently represent a hydrogen atom, a hydroxyl group, a halogen atom or an optionally substituted alkoxy group; provided that where R¹ and R² both represent a hydrogen atom, A¹, A², B¹ and B² on the two benzene rings all represent a hydrogen atom or, otherwise, the two substituents on at least one benzene ring have the meaning other than a hydrogen atom, and a pharmaceutically acceptable salt thereof are disclosed. The compounds are useful as improving and treating agents for cerebral organic disorders and psychic function disorders.

Description: This invention relates to a novel cyclopropachromen derivative represented by formula (I) shown below and a pharmaceutically acceptable salt thereof. The compounds according to the present invention have a wide use as improving and treating agents for cerebral organic and functional disorders. Living cerebral cells maintain their intracellular environment quite differently from the surrounding environment (extracellular fluid). Maintenance of such a difference requires constant production and supply of energy. Most of the energy required for cerebral nerve cells is furnished by oxygen and glucose. These energy sources, not substantially stored in the brain, must always be supplied from blood. Should some disturbance take place in the brain resulting in a cut off of the supply of oxygen and glucose, it generally follows that an metabolic energy deficiency would stepwise proceed, and the cells would gradually lose their functions over time and eventually undergo structural disintegration and fail to perform their normal functions. Hence, the brain has a well-developed mechanism for conditioning the blood flow of its own blood vessels in order to stably supply energy sources to the cerebral tissue and to maintain the extracellular environmental conditions constant. For internal treatments of disturbances of cerebral blood vessels, various kinds of drugs such as cerebral circulation improving agents, cerebral vasodilators, cerebral metabolism improving agents, and the like have been made use of. Under the present circumstances, however, these drugs bring about no substantial alleviation in neurotic or psychic symptoms, though alleviation in subjective symptoms are obtained. EP-A-0238883 discloses various oxabicycloheptane derivatives which are pharmacologically useful for ameliorating or eliminating the symptoms that appear either as a result of organic disorders in the brain or on account of pathergasia. The inventors have conducted extensive and intensive studys on a compound effective for improving and treating symptoms arising from various disturbances in the brain. As a result, it has now been found that the novel cyclopropachromen derivatives and their salts according to the present invention are extremely effective for treatment of various oxygen deficit conditions (cerebral anoxia) in cerebral nerve cells which are believed to be closely related to the above-mentioned disturbances, thus completing the present invention. The novel cyclopropachromen derivatives of the present invention exhibit cerebral function improving activities in experimental model animals suffering from various cerebral anoxemic conditions even at low dose levels and are, therefore, effective in alleviating and treating organic and functional disorders. The present invention provides a cyclopropachromen derivative represented by formula (I): wherein n represents an integer of 2 to 5; R 1 and R 2 independently represent a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; A 1 and A 2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or a C 1-10 alkoxy group optionally substituted by a phenyl group or a pyridyl group; B 1 and B 2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or a C 1-10 alkoxy group optionally substituted by a phenyl group or a pyridyl group; with the proviso that both substituents or at least one of the benzene rings represent substituents other than hydrogen atoms, and a pharmaceutically acceptable salt thereof. The term "halogen" as used herein includes fluoro, chloro, bromo or iodo, and fluoro, chloro and bromo are preferred. The integer represented by n is preferably 2 - 4 and more preferably 2 or 3. Examples of the alkyl group represented by R 1 and R 2 may be straight or branched. Those having 1 - 3 carbon atoms such as methyl and ethyl are preferred. Examples of the aralkyl group represented by R 1 and R 2 include benzyl and phenethyl. It should be understood that the compound of the present invention comprises several isomers as schematically illustrated below. Namely, there are two geometrical isomers (E-form and Z-form) at the oxime structure, and further, each of the geometrical isomers has two optical isomers. Each isomers can be separated by a conventional manner by way of, e.g. recrystallization, column chromatography, TLC, HPLC or by using a chemical substance commonly used in the separation of optical isomers. The compounds represented by formula (I) can be synthesized in accordance with the process described in Japanese Patent Application Laid-Open No. Sho-62-198676 as illustrated by the following reaction scheme: Compound (II) is reacted with hydroxylamine hydrochloride in pyridine to obtain compound (III). Compound (III) is then condensed with a halogenated amine compound of formula: wherein R 1 , R 2 and n are as defined above; and X represents a halogen atom, to obtain compound (I). Alternatively, compound (III) is condensed with a bifunctional compound represented by formula: X 1 - (CH 2 ) n - X 2 wherein X 1 represents a halogen atom; and X 2 represents a halogen atom or an ethylene oxide group, to form compound (IV), which is then reacted with an appropriate amine compound to obtain compound (I). The starting compound (II) is known per se as disclosed in P. Bennett, et al., J. Chem. Soc., Perkin Trans., I, No. 12, p. 2990 (1979) or can be synthesized by the process disclosed therein. The compounds according to the present invention have low toxicity and can be formulated either as such or as a salt thereof, such as inorganic acid salts (e.g., hydrochloride, sulfate, nitrate, phosphate), organic acid salts (e.g., acetate, propionate, butyrate, tartrate, malonate, succinate, maleate, fumarate, oxalate, citrate, malate, p-toluenesulfonate, methanesulfonate), and alkali metal salts (e.g., sodium salt, potassium salt) in cases where either A 1 or A 2 is a hydroxyl group, together with known carriers into various preparations for the improvement and treatment of symptoms caused by various disturbances in the brain. For example, the active ingredient is formulated either alone or in combination with commonly employed vehicles, etc. into appropriate dosage forms for oral or non-oral administration, such as capsules, tablets, injectable solutions, etc. These preparations can be prepared, for example, as follows. Capsules are prepared by mixing a powdered active ingredient with vehicles, e.g., lactose, starch or a derivative thereof, a cellulose derivative, etc., and charging the mixture in gelatin capsules. Tablets are prepared by mixing the active ingredient with the above-mentioned vehicles and, in addition, binders, e.g., sodium carboxymethyl cellulose, alginic acid, gum arabic, etc., and water, granulating the mixture if desired, adding lubricants, e.g., talc, stearic acid, etc., to the mixture, and punching the mixture by means of a conventional compressive punching machine. Injectable solutions for non-oral administration are prepared by dissolving the active ingredient in sterilized distilled water or sterilized physiological saline together with dissolving aids and sealing the solution into ampules. If desired, the injectable solutions may contain stabilizers, buffering agents, and so on. Synthesis of the compounds according to the present invention will be illustrated below by way of Reference Examples and Examples. Reference Examples relate to preparation of starting compounds to be used in the synthesis of the compounds of formula (I). Reference Examples are referred to with a combination of two numbers, in which the first number corresponds to the above-mentioned formula (II) to (IV) [e.g., Reference Example II-1 relates to preparation of compound (II)]. Reference Example II-1 1a,7a-dihydro-4,5-dimethoxy-1a-phenylcyclopropa[b]chromen-7-(1H)-one In 100 mℓ of dimethyl sulfoxide was dissolved 6.78 g (30.8 mmol) of trimethylsulfoxonium iodide, and 1.24 g (30.8 mmol) of sodium hydride (60% oil dispersion) was added to the solution in small portions. The mixture was stirred until evolution of hydrogen ceased. A dimethyl sulfoxide solution having dissolved therein 5.82 g (20.5 mmol) of 6,7-dimethoxyflavone was then added to the reaction mixture, followed by stirring at room temperature for 4 hours. The reaction mixture was poured into ice-water and extracted with diethyl ether. The extract was washed with water and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated, and the residue was purified by silica gel column chromatography using a mixed solvent of hexane-ethyl acetate (70:30) as an eluent to obtain 2.72 g (yield: 44.8%) of the titled compound. Reference Examples II-2 to II-6 The following compounds were synthesized in the same manner as in Reference Example II-1. 1a,7a-dihydro-3,4-dimethoxy-1a-phenylcylopropa[b]chromen-7(1H)-one (Reference Example II-2); 4,5-dichloro-1a,7a-dihydro-1a-phenylcyclopropa[b]chromen-7(1H)-one (Reference Example II-3); 4,5-dibenzyloxy-1a,7a-dihydro-1a-phenylcylopropa[b]chromen-7(1H)-one (Reference Example II-4); 1a-(3,4-dichlorophenyl)-1a,7a-dihydrocyclopropa[b]chromen-7(1H)-one (Reference Example II-5); 1a,7a-dihydro-1a-(3,4-dimethoxyphenyl)cyclopropa[b]chromen-7(1H)-one (Reference Example II-6); Physical properties of the compounds obtained in Reference Examples II-1 through II-6 are shown in Table 1 below. Reference Example III-1 1a,7a-dihydro-4,5-dimethoxy-7(1H)-hydroxyimino-1a-phenylcyclopropa[b]chromen In 50 mℓ of pyridine was dissolved 500 mg (1.69 mmol) of the compound obtained in Reference Example II-1, and 469 mg (6.76 mmol) of hydroxylamine hydrochloride was added thereto, followed by stirring at 100°C for 1 hour. The reaction mixture was concentrated, diluted with water, and extracted with chloroform. The chloroform extract was washed with water and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated, and the residue was purified by silica gel column chromatography using a mixed solvent of hexane-ethyl acetate (2:1 by volume) as an eluent to obtain 492 mg (93.6%) of the titled compound. Reference Examples III-2 to III-6 The following compounds were synthesized in the same manner as in Reference Example III-1. 1a,7a-dihydro-3,4-dimethoxy-7(1H)-hydroxyimino-1a-phenylcyclopropa[b]chromen (Reference Example III-2); 4,5-dichloro-1a,7a-dihydro-7(1H)-hydroxyimino-1a-phenylcyclopropa[b]chromen (Reference Example III-3); 4,5-dibenzyloxy-1a,7a-dihydro-7(1H)-hydroxyimino-1a-phenylcyclopropa[b]chromen (Reference Example III-4); 1a-(3,4-dichlorophenyl)-1a,7a-dihydro-7(1H)-hydroxyiminocyclopropa[b]chromen (Reference Example III-5); 1a,7a-dihydro-1a-(3,4-dimethoxyphenyl)-7(1H)-hydroxyiminocyclopropa[b]chromen (Reference Example III-6); Physical properties of the compounds obtained in Reference Examples III-1 through III-6 are shown in Table 2 below. Reference Example IV-1 7(1H)-(2-chloroethyloxyimino)-4,5-dimethoxy-1a,7a-dihydro-1a-phenylcyclopropa[b]chromen In 20 mℓ of dioxane was dissolved 300 mg of the compound obtained in Reference Example III-1, and 57.9 mg (1.5 equivalents) of sodium hydride (60% oil dispersion) was added to the solution. Then, 0.482 mℓ (6 equivalents) of 1-bromo-2-chloroethane was added thereto, and the reaction mixture was heated at 100°C for 5 hours with stirring, followed by concentration. The residue was diluted with water and extracted with diethyl ether. The diethyl ether layer was washed with water and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated, and the residue was purified by silica gel column chromatography using a mixed solvent of hexane and ethyl acetate (85:15 by volume) as an eluent to obtain 275 mg (76.3%) of the titled compound. Reference Example IV-2 7(1H)-(3-chloropropyloxyimino)-4,5-dimethoxy-1a,7a-dihydro-1a-phenylcyclopropa[b]chromen The titled compound was synthesized from the compound of Reference Example III-1 in the same manner as in Reference Example IV-1. Physical properties of the compounds obtained in Reference Examples IV-1 and IV-2 are shown in Table 3 below. Example 1 1a,7a-dihydro-4,5-dimethoxy-7(1H)-(2-methylaminoethyloxyimino)-1a-phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-OCH 3 ; A 2 = 5-OCH 3 ; B 1 = H; B 2 = H; NR 1 R 2 = NHCH 3 ; and n = 2] In 10 mℓ of dioxane was dissolved 270 mg of the compound obtained in Reference Example IV-1, and 10 mℓ of a saturated mono-methylamine solution in dioxane was added to the solution. The mixture was heated in a closed tube at 100°C for 17 hours and then freed of dioxane by distillation. Water and a sodium hydroxide aqueous solution were added to the residue, and the residue was extracted with methylene chloride. The extract was washed with water and dried over magnesium sulfate. After filtration, the filtrate was concentrated, and the residue was purified by silica gel column chromatography using a mixed solvent of methylene chloride and methanol (9:1) as an eluent to obtain 165 mg (62.0%) of the titled compound. The resulting compound was converted to its L-tartrate in a usual manner. Example 2 4,5-dichloro-1a,7a-dihydro-7(1H)-(2-dimethylaminoethyloxyimino)-1a -phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-Cl; A 2 = 5-Cl; B 1 = H, B 2 = H; NR 1 R 2 = N(CH 3 ) 2 ; and n = 2] In 7 mℓ of tetrahydrofuran was dissolved 95 mg (0.3 mmol) of the compound obtained in Reference Example III-3, and 18 mg (0.45 mmol) of sodium hydride (60% oil dispersion) was added thereto, followed by stirring at room temperature for 45 minutes. To the reaction mixture was added 128 mg (1.19 mmol) of dimethylaminoethyl chloride, followed by refluxing under heating for 17 hours. The reaction mixture was concentrated, and the residue was diluted with ice-water and extracted with diethyl ether. The extract was washed with water and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated, and the residue was purified by neutral silica gel column chromatography using a mixed solvent of methylene chloride and methanol (95:5) as an eluent to obtain 112 mg (99.0%) of the titled compound. The resulting compound was converted to its maleate in a usual manner. The physical properties of the maleate are shown in Table 4 below. Example 3 1a,7a-dihydro-4,5-dimethoxy-7(1H)-(2-dimethylaminoethyloxyimino)-1a -phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-OCH 3 ; A 2 = 5-OCH 3 ; B 1 = H; B 2 = H; NR 1 R 2 = N(CH 3 ) 2 ; n = 2] The titled compound was synthesized from the compound of Reference Example III-1 in the same manner as in Example 2. Example 4 1a-(3,4-dichlorophenyl)-1a,7a-dihydro-7(1H)-(2-dimethylaminoethyloxyimino)cyclopropa[b]chromen [Compound of formula (I) wherein A 1 = H; A 2 = H; B 1 = 3-Cl; B 2 = 4-Cl; NR 1 R 2 = N(CH 3 ) 2 ; n = 2] The titled compound was synthesized from the compound of Reference Example III-5 in the same manner as in Example 2. Example 5 7(1H)-2-(diethylaminoethyloxyimino)-1a,7a-dihydro-4,5-dimethoxy-1a-phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-OCH 3 ; A 2 = 5-OCH 3 ; B 1 = H; B 2 = H; NR 1 R 2 = N(C 2 H 5 ) 2 ; n = 2] The titled compound was synthesized from the compound of Reference Example III-1 in the same manner as in Example 2. Example 6 4,5-dichloro-1a,7a-dihydro-7(1H)-(3-methylaminopropyloxyimino)-1a-phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-Cl; A 2 = 5-Cl; B 1 = H; B 2 = H; NR 1 R 2 = NHCH 3 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-3 in the same manner as in Example 2. Example 7 1a,7a-dihydro-4,5-dimethoxy-7(1H)-(3-methylaminopropyloxyimino)-1a-phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-OCH 3 ; A 2 = 5-OCH 3 ; B 1 = H; B 2 = H; NR 1 R 2 = NHCH 3 ; n = 3] The titled compound was synthesized from the compound of Reference Example IV-2 in the same manner as in Example 1. Example 8 1a-(3,4-dichlorophenyl)-1a,7a-dihydro-7(1H)-(3-methylaminopropyloxyimino)cyclopropa[b]chromen [Compound of formula (I) wherein A 1 = H; A 2 = H; B 1 = 3-Cl; B 2 = 4-Cl; NR 1 R 2 = NHCH 3 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-5 in the same manner as in Example 2. Example 9 4,5-dichloro-1a,7a-dihydro-7(1H)-(3-ethylaminopropyloxyimino)-1a-phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-Cl; A 2 = 5-Cl; B 1 = H; B 2 = H; NR 1 R 2 = NHC 2 H 5 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-3 in the same manner as in Example 2. Example 10 1a-(3,4-dichlorophenyl)-1a,7a-dihydro-7(1H)-3-ethylaminopropyloxyimino)cyclopropa[b]chromen [Compound of formula (I) wherein A 1 = H; A 2 = H; B 1 = 3-Cl; B 2 = 4-Cl; NR 1 R 2 = NHC 2 H 5 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-5 in the same manner as in Example 2. Example 11 1a,7a-dihydro-7(1H)-(3-dimethylaminopropyloxymino)-3,4-dimethoxy-la-phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 3-OCH 3 ; A 2 = 4-OCH 3 ; B 1 = H; B 2 = H; NR 1 R 2 = N(CH 3 ) 2 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-2 in the same manner as in Example 2. Example 12 4,5-dichloro-1a,7a-dihydro-7(1H)-(3-dimethylaminopropyloxyimino)-1a -phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-Cl; A 2 = 5-Cl; B 1 = H; B 2 = H; NR 1 R 2 = N(CH 3 ) 2 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-3 in the same manner as in Example 2. Example 13 1a,7a-dihydro-4,5-dimethoxy-7(1H)-(3-dimethylaminopropyloxyimino)-1a -phenylcyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-OCH 3 ; A 2 = 5-OCH 3 ; B 1 = H; B 2 = H; NR 1 R 2 = N(CH 3 ) 2 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-I in the same manner as in Example 2. Example 14 4,5-dibenzyloxy-1a,7a-dihydro-7(1H)-(3-dimethylaminopropyloxyimino)cyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-OCH 2 -C 6 H 5 ; A 2 = 5-OCH 2 -C 6 H 5 ; B 1 = H; B 2 = H; NR 1 R 2 = N(CH 3 ) 2 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-4 in the same manner as in Example 2. Example 15 1a-(3,4-dichlorophenyl)-1a,7a-dihydro-7(1H)-(3-dimethylaminopropyloxyimino)cyclopropa[b]chromen [Compound of formula (I) wherein A 1 = H; A 2 = H; B 1 = 3-Cl; B 2 = 4-Cl; NR 1 R 2 = N(CH 3 ) 2 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-5 in the same manner as in Example 2. Example 16 1a,7a-dihydro-7(1H)-(3-dimethylaminopropyloxyimino)-1a-(3,4-dimethoxyphenyl)cyclopropa[b]chromen [Compound of formula (I) wherein A 1 = H; A 2 = H; B 1 = 3-OCH 3 ; B 2 = 4-OCH 3 ; NR 1 R 2 = N(CH 3 ) 2 ; n = 3] The titled compound was synthesized from the compound of Reference Example III-6 in the same manner as in Example 2. Example 17 1a,7a-dihydro-4,5-dihydroxy-7(1H)-(3-dimethylaminopropyloxyimino)cyclopropa[b]chromen [Compound of formula (I) wherein A 1 = 4-OH; A 2 = 5-OH; B 1 = H; B 2 = H; NR 1 R 2 = N(CH 3 ) 2 ; n = 3] In 20 mℓ of ethyl acetate was suspended 48 mg of 10% palladium-on-carbon. After displacing the atmosphere with hydrogen by suction, 240 mg of the compound obtained in Example 14 was added to the suspension, and the mixture was stirred at room temperature for 5 hours in a hydrogen stream (atmospheric pressure). The reaction mixture was worked-up in the same manner as in Example 2 to obtain 67.0 mg (41.5%) of the titled compound. Physical properties of the compounds obtained in Examples 1 to 17 are shown in Table 4 below. Test Example Antihypoxia Activity (Brain-Protecting Activity against Oxygen Deficit under Reduced Pressure) Male mice of ddy strain weighing 22 to 30 g (7 to 10 mice per group) were placed in a desiccator having a capacity of about 1 ℓ, and the inner pressure was reduced to 180 mmHg by suction with a vacuum pump. Thirty minutes before the pressure reduction, a test group intraperitoneally received a solution of 25 mg/kg of a test compound, while a control group received only the solvent. A survival time of from the start of pressure reduction up to the respiratory cessation was measured. In cases when an animal survived more than 15 minutes from the hypoxia induction, the survival time was scored to be 15 minutes. As a result, the compound of the present invention significantly extended the survival time over that of the control group.

Claims: Claims for the following Contracting States : AT, BE, CH, DE, DK, FR, GB, IT, LI, LU, NL, SE A cyclopropachromen derivative represented by formula (I) : wherein n represents an integer of 2 to 5; R 1 and R 2 independently represent a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; A 1 and A 2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or a C 1-10 alkoxy group optionally substituted by a phenyl group or a pyridyl group; B 1 and B 2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or a C 1-10 alkoxy group optionally substituted by a phenyl group or a pyridyl group; with the proviso that both substituents or at least one of the benzene rings represent substituents other than hydrogen atoms, and a pharmaceutically acceptable salt thereof. A compound as claimed in Claim 1 wherein one of R 1 and R 2 represents a hydrogen atom and the other represents an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms, and A 1 and A 2 both represent a meaning other than a hydrogen atom. A compound as claimed in Claim 2 wherein A 1 and A 2 independently represent an alkoxy group having 1 to 5 carbon atoms which may optionally be substituted with a phenyl group, or represent a halogen atom or a hydroxyl group. A compound as claimed in Claim 1 wherein one of R 1 and R 2 represents a hydrogen atom and the other represents an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms, and B 1 and B 2 both represent a meaning other than a hydrogen atom. A compound as claimed in Claim 4 wherein B 1 and B 2 independently represent an alkoxy group having 1 to 5 carbon atoms or a halogen atom. A compound as claimed in Claim 1 wherein R 1 , R 2 , A 1 and A 2 all represent a meaning other than a hydrogen atom. A compound as claimed in Claim 1 wherein R 1 , R 2 , B 1 and B 2 all represent a meaning other than a hydrogen atom. A cyclopropachromen derivative according to Claims 1 to 7 or its pharmaceutically acceptable salt for use as a medicament. Use of a cyclopropachromen derivative according to Claims 1 to 7 or its pharmaceutically acceptable salt for the manufacture of a medicament for cerebral organic and functional disorders. Claims for the following Contracting States : ES, GR A method for preparing a cyclopropachromen derivative represented by formula (I): wherein n represents an integer of 2 to 5; R 1 and R 2 independently represent a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms; A 1 and A 2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or a C 1-10 alkoxy group optionally substituted by a phenyl group or a pyridyl group; B 1 and B 2 independently represent a hydrogen atom, a hydroxyl group, a halogen atom or a C 1-10 alkoxy group optionally substituted by a phenyl group or a pyridyl group; with the proviso that both substituents or at least one of the benzene rings represent substituents other than hydrogen atoms, and a pharmaceutically acceptable salt thereof, by reacting a compound of formula (II): wherein A 1 , A 2 , B 1 and B 2 are defined as above with hydroxylamine hydrochloride in pyridine to obtain compound (III): and then condensing compound (III) with a halogenated amine compound of formula wherein R 1 , R 2 and n are as defined above, and X represents a halogen atom, to obtain compound (I), or by condensing compound (III) with a bifunctional compound represented by formula: X 1 - (CH 2 ) n - X 2 wherein X 1 represents a halogen atom and X 2 represents a halogen atom or an ethylene oxide group, to form compound (IV): and then reacting compound (IV) with an appropriate amine compound to obtain compound (I) and by optionally converting compound (I) in its pharmaceutically acceptable salt. A method for preparing a cyclopropachromen derivative according to claim 1 wherein one of R 1 and R 2 represents a hydrogen atom and the other represents an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms, and A 1 and A 2 both represent a meaning other than a hydrogen atom. A method for preparing a cyclopropachromen derivative according to claim 2 wherein A 1 and A 2 independently represent an alkoxy group having 1 to 5 carbon atoms which may optionally be substituted with a phenyl group, or represent a halogen atom or a hydroxyl group. A method for preparing a cyclopropachromen derivative according to claim 1 wherein one of R 1 and R 2 represents a hydrogen atom and the other represents an alkyl group having 1 to 5 carbon atoms, a phenyl group or an aralkyl group having 7 to 10 carbon atoms, and B 1 and B 2 both represent a meaning other than a hydrogen atom. A method for preparing a cyclopropachromen derivative according to claim 4 wherein B 1 and B 2 independently represent an alkoxy group having 1 to 5 carbon atoms or a halogen atom. A method for preparing a cyclopropachromen derivative according to claim 1 wherein R 1 , R 2 , A 1 and A 2 all represent a meaning other than a hydrogen atom. A method for preparing a cyclopropachromen derivative according to claim 1 wherein R 1 , R 2 , B 1 and B 2 all represent a meaning other than a hydrogen atom. Use of a cyclopropachromen derivative as defined in claims 1 to 7 or its pharmaceutically acceptable salt for the manufacture of a medicament. Use of a cyclopropachromen derivative as defined in claims 1 to 7 or its pharmaceutically acceptable salt for the manufacture of a medicament for cerebral and functional disorders. A method for preparing a medicament by mixing a cyclopropachromen derivative as defined in claims 1 to 7 or its pharmaceutically acceptable salt with other ingredients. A method for preparing a medicament for cerebral and functional disorders by mixing a cyclopropachromen derivative as defined in claims 1 to 7 or its pharmaceutically acceptable salt with other ingredients.

Inventors: NOMURA KAYOKO, TATSUOKA TOSHIO, NOMURA, KAYOKO, TATSUOKA, TOSHIO
Applicants: SUNTORY LTD, SUNTORY LIMITED
Application year: 1991
Main classification: C07D311
IPC codes: A61K31, A61P25, C07D311