HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE

Abstract: The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.

Description: Heterocyclic Compounds and Their Preparation and Use The present invention relates to therapeutically active heterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the com¬ pounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease. Due to the in general improved health situation in the western world, elderly-related diseases are much more com¬ mon now than in the past and are likely to be ever, more common in the future. One of the elderly-related symptoms is a reduction of the cognitive functions. This symptom is especiall pronounced in the patophysiologicεl disease known as Alzheimer's dis¬ ease. This disease is combined witn,. and also -res: likely caused by, a up to 90 degeneration cf t e muscarinic cho¬ linergic neurons in nucleus basalis, whicr. is car * ; of sub- stantia innominata. These neurons project to the prefron- tal cortex and hippocampus and have a general stimulatory effect on the cognitive functions of the forebrain as well as of hippocampus, namely learning, association, consoli ¬ dation, and recognition. It is a characteristic cf Alzheimer's disease tr.εt although the cholinergic neurons degenerate, then the postsynaptic muscarinic receptors in the forebrain and hippocampus still exist. Therefore muscarinic cholinergic agonists are use¬ ful in the treatment cf Alzheimer's disease and :: * . i prov- ing the cognitive functions of elderly people. It is well known that arecoline (methyl 1-methyl-l,2,5, 6- tetrahydropyridine-3-carboxylate) is such a cholinergic agonis - Arecoline however has a very short biological half life and a small separation between central and peripheral muscarinic effects. Furthermore arecoline is a rather toxic compound. EP-A-0307142 discloses a class of thiadiazoles, substitut¬ ed on one of the ring carbon atoms with a non-aromatic aza¬ cyclic or azabicyclic ring system, and substituted on the other ring carbon atom with a substituent of low lipophi- licity, or a hydrocarbon substituent, which are muscarinic agonists and therefore useful in the treatment of neurolo¬ gical and mental illnesses and severe painful conditions. It is an object of the invention to provide new muscarinic cholinergic compounds. The novel compounds of the invention are heterocyclic compounds having the formula I 2 wherein Z independently is oxygen or sulphur; R is R , R 2 ZR 3 , R 2 CO-,R 2 COR 3 , -CO-, R 2 C0_-, R 2 C0 2 R 3 , -CO.,-. -CONH-, R CONH- , R 2 C0NHR 3 or P. 2 HCONH 2 wherein R 2 and R~ indepen¬ dently are straight or branched C. , .--alkyl, straight or branched C 2 _ 15 -alkenyl, or straight or branched C 2 _- 5 -al- kynyl, substituted with one to three halogens, CF 3 , -OH-, -CN, -CHO, - 0 2 , -C0 2 R 2 , -SOR 2 , -S0 2 R 2 , -CH=NOR 2 , -NR 2 R 3 , one or two phenyl, phenoxy, benzoyl or benzyloxycarbonyl groups optionally substituted with halogen, -CN, C- .-al- kyl or C, ^ -alkoxy, or a 5 or 6 membered heterocyclic group containing one to three N, 0 or S atom(s) or a com¬ bination thereof being saturated, partly saturated or aro¬ matic; R is H, straight or branched C 1 _ 5 -alkyl, straight or branched C 2 _ 5 *-alkenyl, or straight or branched C 2 _ 5 ~ alkynyl, or a salt thereof with a pharmaceutically- acceptable acid. Examples of such salts include inorganic and organic acid addition salts such as hydrochloride, hydrobromide, sul¬ phate, phosphate, acetate, fumarate, maleate, citrate, lactate, tartrate, oxalate, or similar pharmaceutically acceptable inorganic or organic acid addition salt. The compounds of this invention are also useful analgesic agents and therefore useful in the treatment of severe painful conditions. Furthermore, the compounds of this invention are useful in the treatment of glaucoma. The invention also relates to a method of preparing the above mentioned compounds, which comprises alkylating a compound having the formula II (ID wherein Z and R have the meanings defined above, with an alkyl halide and reducing the compound thus formed with hydride ions to form a compound having the formula I wherein Z , R and R have the meanings defined above. The pharmacological properties of the compounds of the invention can be illustrated by determining their capabi¬ lity to inhibit the specific binding of 3 H-0xotremorine-M ( 3 H-0xo). Birdsdall N.J. ., Hul e E.C., and Burgen A.S.V. (1980). "The Character of Muscarinic Receptors in Different Regions of the Rat Brain". Proc. Roy. Soc. London (Series B) 207,1. 3 H-0xo labels muscarinic receptor in the CKS (with a pre¬ ference for agonist domaines of the receptors ) . Three dif- ferent sites are labelled by 3 H-0xo. These sites have affi¬ nity of 1.8, 20 and 3000 nM, respectively. Using the pre¬ sent experimental conditions only the high and medium affi¬ nity sites are determined. The inhibitory effects of compounds on 3 H-0xo binding re¬ flects the affinity for muscarinic acetylcholine receptors. All preparations are performed at 0-4°C unless otherwise indicated. Fresh cortex t 0.1-1 g) from male istar rats (150-250 g) is homogenized for 5-10 s in 10 ml 2Z mM Hepes pH: 7.4, with an Ultra-Turrax homogenizer. The homogenizer is rinsed with 10 ml of buffer and the combined suspension centrifuged for 15 min at 40,000 *< g. The pellet is washed three times with buffer. In each step the pellet is homo¬ genized as before in 2*10 ml of buffer and centrifuged for 10 min at 40,000 x g. The final pellet is homogenized in 20 mM Hepes pH: 7-4 (100 ml per g of original tissue) and used for binding assay. Aliquots of 0.5 ml is added 25 μl of test solution and 25 μl of 3 H-0xotremorine (1.0 nM, final concentration) mixed . and incubated for 30 min at 25°C. Non-specific binding is determined in triplicate using arecoline (1 μg/ml, final concentration) as the test substance. After incubation samples are added 5 ml of ice-cold buffer and poured di¬ rectly onto Whatman GF/C glass fiber filters under suction and immediately washed 2 times with 5 ml of ice-cold buf¬ fer. The amount of radioactivity on the filters are deter¬ mined by conventional liquid scintillation counting. Spe¬ cific binding is total binding minus non specific binding. Test substances are dissolved in 10 ml water (if necessary heated on a steambath for less than 5 minutes ) at a concen¬ tration of 2.2 mg/ml. 25-75% inhibition of specific binding must be obtained before calculation of ICo,-,u.. The test value will be g 3 iven as IC,5-0,-. (the concentration (ng/ml) of the test substance which inhibits the specific binding of 3 K-0xo by 50%). IC 'j5- n 0 = (applied test substance concentration) 1 x ng/ml ( 1) C where C is specific binding in control assays and C is the specific binding in the test assay. (The calculations assume normal mass-action kinetics) . Test results obtained by testing some compounds of the present invention will appear from the following table 1. TABLE 1 Inhibition in vitro OXO BINDING Compound No. (ng/ml) 1 0.39 2 0.47 3 1.2 4 0.43 5 0.54 6 0.33 7 1.1 8 0.44 10 1.0 11 3.2 12 7.2 13 14 14 18 15 8.2 16 5.9 17 4.9 18 6.4 19 1.8 20 3.9 21 2.1 22 2.0 23 2.0 24 7.9 28 1.6 29 3.0 30 5.4 31 4.3 32 0.62 33 13 34 1.6 35 5.2 36 6.4 37 4.5 38 20 39 9.2 40 2.1 41 12 43 285 44 19 45 10 47 26 The compounds of the invention, together v.-itr. a ::r.ventionεi adjuvant, carrier, or diluent, and if desire:: ir. tr.e form of a pharmaceutically-aeceptable acid add: tier, ≤a.t thereof, may be placed into the form of pharmaceutical cc- ositions and unit dosages thereof, and in such form may r-Ξ employed as solids, such as tablets or filled capsules. :: liquids, such as solutions, suspensions, emulsions, elixirs, or cap- sules filled with the same, all for oral use, : * . tr.e form of suppositories for rectal administration; or ir. z . form of sterile injectable solutions for parenteral ..-.eluding subcutaneous) use. Such pharmaceutical compositions and unit dosage forms thereof may comprise conventicr.al ingre- dients in conventional proportions, with or v:itr.:_t addi¬ tional active compounds or principles, and sue. * *. ..-.it do¬ sage forms may contain any suitable effective .srarinic cholinergic agonistic amount of the active ingredient com¬ mensurate with the intended daily dosage range to be em¬ ployed. Tablets containing ten (10) milligrams of the ac¬ tive ingredient or, more broadly, one (1) to hundred (100) milligrams, per tablet, are accordingly suitable represen¬ tative unit dosage forms. The compounds of this invention can thus be used for the formulation of pharmaceutical preparations, e.g. for oral and parenteral administration to mammals including humans, in accordance with conventional methods of galenic pharmacy. Conventional excipients are such pharmaceutically-aeceptable organic or inorganic carrier substances suitable for paren- teral or enteral application which do not deleteriously react with the active compounds. Examples of such carriers are water, salt solutions, alcohols, polyethylene glycols, polyhydroxyethoxylated castor oil, gelatine, lactose, amylose, magnesium stearate, talc, silicic acid, fatty acid monoglycerides and ciglyce- rides, pentaerythritol fatty acid esters, hycrcxyme hyl- cellulose and polyvinylpyrrolidone. The pharmaceutical preparations can be sterilized and mixed, if desired, with auxiliary agents, emulsifiers, salt for influencing osmotic pressure, buffers and/or coloring substances and the like, -which do not deleteriously react with the active compounds. For parenteral application, particularly suitable are injectable solutions or suspensions, preferably aqueous solutions with the active compound dissolved in polyhydroκy- lated castor oil. Ampoules are convenient unit dosage forms. Tablets, dragees, or capsules having talc and/or a carbohy¬ drate carrier or binder or the like, the carrier preferably being lactose and/or corn starch and/or potato starch, are particularly suitable for oral application. A syrup, elixir of the like can be used in cases where a sweetened vehicle can be employed. Generally, the compounds of this invention are dispensed in unit form comprising 1-100 mg in a pharmaceutically accept- able carrier per unit dosage. The dosage ot the compounds according to this invention is 1-100 mg/day, preferably 10-70 g/day, when administered to patients, e.g. humans, as a drug. A typical tablet which may be prepared by conventional tabletting techniques contains: Active compound 5.0 mg Lactosum 67.8 mg Ph.Eur. Avicel 31.4 mg A berlite 1.0 mg Magnesii stearas 0.25 mg Ph.Eur. Due to the high muscarinic cholinergic receptor agonistic activity, the compounds of the invention are extremely use¬ ful in the treatment symptoms related to a reduction of the cognitive functions of the brain of mammals, when admini- stered in an amount effective for stimulating the cognitive functions of the forebrain and hippocampus. The important stimulating activity of the compounds of the invention includes both activity against the patophysiological disease, Alzheimer's disease as well as against normal degeneration of brain function. The compounds of the inventicr. may accordingly be administered to a subject, e.g., a living animal body, including a human, in need of stimulation of the cognitive functions of the forebrain and hippocampus, and if desired in the form of a pharmaceutically-aeceptable acid addition salt thereof (such as the hydrobromide, hydrochloride, or sulfate, in any event prepared in the usual or conventional manner, e.g., evaporation to dryness of the free base in solution together with the acid), ordinarily concurrently, simultaneously, or together with a pharmaceutically-aeceptable carrier or diluent, especially and preferably in the form of a pharmaceutical composition thereof, whether by oral, rectal, or parenteral (including subcutaneous) route, in an effective forebrain and hippo¬ campus stimulating amount, and in any event an amount which is effective for improving the cognitive function of mammals due to their muscarinic cholinergic receptor agonistic activity. Suitable dosage ranges are 1-100 milligrams daily, 10-100 milligrams daily, and especially 30-70 milligrams daily, depending as usual upon the exact mode of administra¬ tion, form in which administered, the indication toward which the administration is directed, the subject involved and the body weight of the subject involved, and the preference and experience of the physician or veterinarian in charge. The invention will now be described in further detail with reference to the following examples: EXAMPLE 1 3-(3-Chloro-l,2,5-thiadiazol-4-yl ) yridine To a solution of sulfurmonochloride (2.4 ml, 30 rr.-r.ol ) in N,N-dimethylformamide (5 ml) was slowly added alpna-amino- alpha(3-pyridyl)acetonitrile (Archive der Phar azie 289 (4) (1956)) (1.70 g, 10 mol ) . The reaction mixture was stirred at room temperature for 18 h. Water (20 r. ) was added and the aqueous phase was extracted with etner and the ether phase discharged. A 50% potassium hydroxide so¬ lution was added to the aqueous phase to pH > 9. The aqu¬ eous phase was extracted several times with ether and the ether phases were dried and evaporated. The residue was purified by column chromatography (Si0 2 , eluent: ethyl acetate/methylene chloride (1:1)). The title compound was collected in 45% (880 mg) yield. M + : 197. EXAMPLE 2 A. 3-(3-(5-Cyanopentylthio)-l,2,5-thiadiazol-4-yl)- pyridine Sodium hydrogen sulfide monohydrate (0.25 g, 3.3 mmol) was added to a solution of 3-(3-chloro-l,2, 5-thiadiazol- 4-yl)pyridine (0.59 g, 3.0 mmol) in DMF (20 ml) at room temperature and the reaction mixture was stirred for 1 h. Potassium carbonate (1.24 g, 9 mmol) and 6-bromocaproni- trile (0.80 g, 4.5 mmol) were added and the reaction mix¬ ture was stirred for additionally 24 h. Water (50 ml) was added and extracted with ether. The combined ether phases were dried and evaporated to give the title compound. B. 3-(3-(5-Cyanopentylthio)-l,2,5-thiadiazol-4-yl)-l- methylpyridinium iodide Methyl iodide (1 ml, 15 mmol) was added to a solution of 3-(3-(5-cyanopentylthio)-l,2,5-thiadiazol-4-yl)pyridine (3 mmol) in acetone and the reaction mixture was stirred at room temperature for 20 h and evaporated. C. 3-(3-(5-Cyanopentylthio)-l,2,5-thiadiazol-4-yl)-l,2,5,6- tetrahydro-1-methylpyridine oxalate Sodium borohydride (290 mg, 7.5 mmol) was added to a solu¬ tion of 3-(3-(5-cyanopentylthio)-l,2,5-thiadiazol-4-yl)- 1-methylpyridinum iodide (3 mmol) in ethanol (99.9%, 20 ml) and the reaction mixture was stirred at -10 C for 1 h. After evaporation the residue was dissolved in water and extracted with ethyl acetate. The dried organic phases were evaporated and the residue purified by column chroma¬ tography (Si0 2 , eluent: ethyl acetate/methanol (4:1)). The title compound was crystallized as the oxalate salt from acetone to yield 410 mg. M.p. 139-140 C. Compound 1. The following compounds were made in exactly the same manner, starting with the appropriate alkyl halogenide: 3-(3-(3-Chloroprθpylthio)-l,2,5-thiadiazol-4-yl)-i,2,5,6- tetrahydro-1-methylpyridine oxalate. M.p. 136-135 C. Compound 2. 3-(3-(3-Cyanopropylthio)-l,2, 5-thiadiazol-4-yl )-l,2, 5, 6- tetrahydro-1-methylpyridine oxalate. M.p. 117.5-118 C. Compound 3. 3-(3-(3-Phenylpropylthio)-l,2,5-thiadiazol-4-yl)-l,2, 5.6- tteettrraahhyyddrroo--:1-methyJ.pyridine oxalate. M.p. 110-11C.5 C. Compound 4. 3-(3-(2-Phenoxyethylthio)-l,2,5-thiadiazol-4-yl)-i,2,5,6- tteettrraahhyyddrroo--1-methylpyridine oxalate. M.p. 125.5-126 C. Compound 5. 3-(3-(4-Cyanobutylthio;-l, 2, 5-thiadiazol-4-yl )-l. ,5, 6- tetrahydro-1-methylpyridine oxalate. M.p. 127-12 " .5 C. -to Compound 6. 3-(3-(8-Hydroxyoctylthio)-l,2,5-thiadiazol-4-yl)-l,2,5,6- tteettrraahhyyddrroo--1-methylpyridine oxalate. M.p. 112.5-113.5°C. Compound 7. 3-(3-(4-Chlorobutylthio)-l,2,5-thiadiazol-4-yl)-l,2,5,6- tteettrraahhyyddrroo--1-methylpyridine oxalate. M.p. 136-137 C. Co pound 8. 3-(3-(4,4-Bis-(4-fluorophenyl)-butylthio)-l, 2, 5-thiadiazol- 4-yl)-l,2,5, 6-tetrahydro-1-methylpyridine oxalate. M.p. 117.5-118°C. Compound 9. 3-(3-(2-(1,3-Dioxolane-2-yl)-ethylthio)-1, 2, 5-thiadiazol- 4-yl)-l,2, 5, 6-tetrahydro-l-methylpyridine oxalate. M.p. 117-118°C. Compound 10. 3-(3-(4-Cyanobenzylthio)-l,2,5-thiadiazol-4-yl)-l,2, 5,6- tteettrraahhyyddπro-1-methylpyridine oxalate. M.p. 136-140°C. Co - pound 11. 3-(3-(2-Phenylethylthio)-l, 2, 5-thiadiazol-4-y )-l, 2, 5, 6- tetrahydro-1-methylpyridine oxalate. M.p. 155-15έ ^ C. Com- pound 12. 3-(3-(4-Bromobenzylthio)-l, 2, 5-thiadiazol- -yl j - l , 2 , 5, 6- tetrahydro-1-methylpyridine oxalate. M.p. 139-140 C. Compound 13. 3-(3-(4-Methylbenzylthio)-1,2, 5-thiadiazol- -yl )-1,2, 5,6- tetrahydro-1-methylpyridine oxalate. M.p. 162-155 C. Compound 14. 3-(3-(4-Pyridylmethylthio)-1,2, 5-thiadiazol- -yl -1,2,5,6- tteettrraahhyyddrroo--i1-methylpyridine oxalate. M.p. 14C-14Ξ C. Compound 15. 3-(3-Benzoylethylthio-l,2,5-thiadiazol-4-yl)-l,2,5,6- tteettrraahhyyddrroo--11■-methylpyridine oxalate. M.p. 99-100°C. Compound 16. 3-(3-(4-0x0-4-(4-fluorophenyl)-butylthio)-1,2,5-thiadia- zol-4-yl)-l,2,5,6-tetrahydro-1-methylpyridine oxalate. M.p. 131-132°C. Compound 17. 3-(3-Benzyloxycarbonylmethylthio-l,2,5-thiadiazol-4-yl) -1,2,5,6-tetrahydro-1-methylpyridine oxalate. M.p. 179- 180°C. Compound 18. 3-(3-Benzylthio-l,2,5-thiadiazol-4-yl)-l,2,5,6- tteettrraahhyyddrroo--1-methylpyridine oxalate. M.p. 195-197 C. Compound 19 3-(3-(4, ,4-Trifluorobutylthio)-1,2,5-thiadiazol-4-yl)- 1,2,5,6-tetrahydro-1-methylpyridine oxalate, m.p. 163- 165°C. Compound 20. 3-(3-(5,5,5-Trifluoropentylthio)-l,2,5-thiadiazol-4-yl)- 1,2,5,6- tetrahydro-1-methylpyridine oxalate, m.p. 134- 136°C. Compound 21. 3-(3-(6,6,6-Trifluorohexylthio)-l,2, 5-thiadiazol-4-yl)- 1,2,5,6-tetrahydro-1-methylpyridine oxalate, m.p. 128- 129°C. Compound 22. 3-(3-Ethoxycarbonylpentylthio)-1,2,5-thiadiazol-4-yl)- 11,,22,,55--tteettrraahrydro-l-methylpyridine oxalate, m.p. 78-81 C. Compound 23. EXAMPLE 3 A. 3-(3-(6,6,6-Trifluorohexyloxy-l,2,5-thiadiazol-4-yl )■ pyridine To a mixture of sodium hydride (12.8 mmol) and 6,6,6-tri- fluoro-1-hexanol (3.0 g, 19.2 mmol) in tetrahydrofuran (40 ml) was added 3-(3-chloro-l,2, 5-thiadiazol-4-yl)-pyri- dine (1.3 g, 6.4 mmol). The mixture was refluxed for 36 h and evaporated. After evaporation the residue was dissolv¬ ed in water then extracted with diethyl ether. The dried organic phases were evaporated and the residue purified by column chromatography (silica gel, eluent: ethyl ace- tate/hexanes) to yield 630 mg (31%) of the title compound. B. 3-(3-( 6, 6, 6-Trifluorohexyloxy-l, 2, 5-thiadiazol-4- yl)-l-methylpyridinium iodide A solution of methyl iodide (852 mg, 6.0 mmol) and 3-(3- (6,6, 6-trifluorohexyloxy-1, 2, 5-thiaciazol-4-yl )-pyridine (630 mg, 2.0 mmol) in acetone (25 ml; was refluxed for 7 h. The solution was evaporated and the residue was used directly in the next step. C. 1,2,5, 6-Tetrahydro-l-methyl-3-(3-( 6,6, 6-trifluorohexyl¬ oxy-1, 2, 5-thiadiazol-4-yl )pyridine oxalate Sodium borohydride (380 mg, 10 mmol) was added to a solu¬ tion of 3-(3-(6, 6, 6-trifluorohexyloxy-1,2,5-thiadiazol- 4-yl )-l-methylpyridiniurr. iodide (2.0 mmol) in ethanol (15 ml) and the reaction mixture was stirred at room tempera- ture overnight. After evaporation the residue was dissolv¬ ed in water and extracted with diethyl ether. The dried organic phases were evaporated and the residue was puri- fied by column chromatography (silica gel, eluent: 25% ethyl acetate in hexanes). The title compound was crystal¬ lized as the oxalate salt from acetone to yield 180 mg (21%), m.p. 138-140°C. Theoretical %C = 45.17, %H = 5.21, %N = 9.88. Found %C = 45.13, %H = 5.18, %N = 9.62. Com¬ pound 24. The following compounds were made in exactly the same manner using the appropriate alkoxy derivative: l,2,5,6-Tetrahydro-l-methyl-3-(3-(3-(2-thienyl)-l-pro- poxy)-l,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 130- 133°C, M + : 321. Compound 25. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(3-(4-methoxyphenyl)-1- propoxy)-1,2, 5-thiadiazol-4-yl)-pyridine oxalate, m.p. 166-167°C, M + : 345. Compound 26. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-(4-methoxyphenyl)-1- ethoxy)-1,2, 5-thiadiazol-4-yl)-pyridine oxalate, m.p. 166-167°C, M + : 331. Compound 27. 1,2,5, 6-Tetrahydro-l-methyl-3-(3-(2-(2-thienyl )-I-ethoxy. 1 1,,22,,55--tthhiiaaddiiaazzooll--44--yy:l)-pyridine oxalate, m.p. 145-146°C, M + : 306. Compound 28. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-(3-thienyl)-1-ethoxy. 1,2, 5-thiadiazol-4-yl)-pyridine oxalate, m.p. 138-140 c, M + : 306. Compound 29. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(3-hydroxy-l-propoxy)- 1,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 105-107 C, M + : 256. Compound 30. l,2,5,6-Tetrahydro-l-methyl-3-(3-(2-phenyl-l-ethoxy)- 1 1,,22,, 55--tthhiiaaddiiaazzooll--44--yyll)-pyridine oxalate, m.p. 146-147 C, M + : 301. Compound 31. 1,2,5,6-Tetrahydro-1-methyl-3-(3-(2-thienylmethoxy)- 1,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 161-162, M + : 294. Compound 32. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(3-hydroxy-l-hexyloxy)- 1,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 147-148 C, M + : 297. Compound 33. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(3-thienylmethoxy)- 1,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 175-176 C, M + : 293. Compound 34. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(3-phenyl-l-propoxy)- 1,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 136-138 C, M + : 315. Compound 35. l,2,5,6-Tetrahydro-l-methyl-3-(3-(3-(l-( 2-pyrrolidone) )- 1-propoxy)-l,2, 5-thiadiazol-4-yl )-pyridine oxalate, m.p. 160-161°C, M + : 322. Compound 36. 1,2,5, 6-Tetrahydro-l-methyl-3-(3-( 6-acetamido-l-hexyl- oxy)-l,2,5-thiadiazol-4-yl )-pyridine oxalate, m.p. 114- 116°C, M + : 338. Compound 37 1,2,5, 6-Tetrahydro-1-methyl-3-(3-(2-acetamido-l-ethoxy )- 1,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 145-148 C, M + : 283. Compound 38. 1,2,5,6-Tetrahydro-1-methyl-3-(3-(2-( 1-(2-pyrrolidinone) ) ■ 1-ethoxy)-l,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 170-171°C, M + : 309. Compound 39. "' 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-propionamido-l- ethoxy)-l,2, 5-thiadiazol-4-yl )-pyridine oxalate, m.p. 148-143°C, M + : 296. Compound 40. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-(3-(2-oxazolidone) )- 1-ethoxy)-l,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 157-159°C, M + : 310. Compound 41. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-benzylthio-1-ethoxy) 1 1,,22,,55--tthhiiaaddiiaazzooll--44--yyl)-pyridine oxalate, m.p. 133-134°C, M + : 347. Compound 42 1,2,5,6-Tetrahydro-l-methyl-3-(3-(3-(1-pyrrolidyl)-1- propoxy)-l,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 141-142°C, M + : 308. Compound 43. 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-carbamoyl-1-ethoxy)- 1,2,5-thiadiazol-4-yl)-pyridine oxalate, m.p. 200 C (de- compose), M : 265. Compound 44. 1,2,5, 6-Tetrahydro-l-methyl-3-(3-(2-( 1-ethylsulfoxido)- 1-ethoxy)-l,2,5-thiadiazol-4-yl)-pyridine oxalate 1,2,5, 6-tetrahydro-l-methyl-3-(3-(2-( 1-ethyisulfoxido)- 1-ethoxy)-l,2, 5-thiadiazol-4-yl)-pyridinε oxalate was pre¬ pared in the same manner using ethyl-1-hydroxyethylsulfi- de as the starting alcohol. The intermediate 3-(-4-(2-(l- ethylsulfido)-1-ethoxy)-l, 2, 5-thiadiazol-3-yl )-p ridine was oxidized with 1.1 equivalent of NalO. and 1 equivalent MeSO-H using water as the reaction solvent. After a reac¬ tion time of 3.5 h "the solution was made basic with 2K NaOH and extracted with ethyl acetate. The combined ex¬ tracts were dried over MgSO. and evaporated under vacuum. The resulting sulfoxide was then converted to the title compound in the same manner described above. M.p. 171- 172°C, M + : 302. Compound 45. 1,2,5,6-Tetrahydro-3-(3-(2-hexanone))-1,2,5-thiadiazol- 4-yl)-1-methylpyridine l,2,5,6-tetrahydro-3-(3-(2-hexanol) )-l,2,5-thiadiazol- 4-yl)-1-methylpyridine was prepared in the same manner using 1,5-hexandiol. Oxidation of this compound to the named ketone was carried out under conditions as follows. To a -70°C solution of oxalylchloride (420 μl, 4.8 mmol) in 25 ml CH 2 C1 2 was added DMSO (750 μl, 10.6 mmol) at a rate so as to maintain the reaction temperature below -45°C. Two min. after the addition 1,2,5,6-tetrahydro-3- (4-(2-hexanol) )-l,2, 5-thiadiazol-4-yl)-1-methylpyridine (1.3 g, 4.4 mmol) in 20 ml CH-Cl- was added slowly, keep- ing the temperature below -45 C. After 15 min. Et-N (3 ml, 21.8 mmol) was added and the reaction was warmed to room temperature. Brine (50 ml) was added and the mixture was extracted three times with 50 ml CH„C1_. The combined ex¬ tracts were dried over Na-SO. and evaporated under vacuum. The resulting oil was chromatographed on silica gel (90% CHC1-, 2% MeOH as eluent), affording 810 m of an oil, which was dissolved in MeOH and treated with oxalic acid (250 mg, 2.8 mmol). The resulting oxalate salt was recrys- tallized from MeOH/EtOAc, affording 860 mg. M.p. 143-144°C, M + : 295. Compound 46. EXAMPLE 4 A. Alpha-oximino-3-pyridylacetonitrile 3-pyridylacetonitrile (47.2 g, 400 mmol) was dissolved in a solution of sodium hydroxide (16 g, 400 mmol) in methanol (100 ml). Methylnitrite, generated by dropping a solution of concentrated sulphuric acid (12.8 ml) and water (26 ml) to a solution of sodium nitrite (33.2 g, 480 mmol) in water (20 ml) and methanol (20 ml), was bobled through the 3-pyridylacetonitrile solution at 0 C. The reaction mixture was stirred at 0 C for 1 h and the precipitate collected by filtration. The precipitate was washed with a little methanol to give the wanted product in 70% (41.1 g) yield. M + : 147. B. Alpha-oximino-3-pyridylacetamidoxime A mixture of alpha-oximino-3-pyridylacetonitrile (41.0 g, 279 mmol). hydroxylamine hydrochloride (21.5 g, 310 mmol) and sodium acetate (50.8 g, 620 mmol) in ethanol (99.9%, 500 ml) was refluxed for 4 h. After cooling, the precipitate was collected by filtration and dried. The precipitate contained the wanted product and sodium acetate (85 g, 168%); M + : 180. C. 3-(3-amino-l, 2, 5-oxadiaxol-4-yl )pyridine Crude alpha-oximino-3-pyridylacetamidoxime (5 g) and phos¬ phorus pentachloride (5 g) was refluxed in dry ether (250 ml) for 6 h. Water and potassium carbonate to alkaline pK was added and the phases separated. The aqueous phase was extracted with ether and the combined ether phases dried. Evaporation of the ether phases gave the title compound in 850 mg yield; M + : 162. D. 3-(3-chloro-l, 2, 5-oxadiazol-4-yl )pyridine To a solution of 3-(3-amino-l, 2, 5-oxadiazol-4-yl )pyridine (1.0 g, 6.2 mmol) in glacial acetic acid (16 ml) and con¬ centrated hydrochloric acid (5.2 ml) was added CuCl 2 (938 mg, 7 mmol) and cupper coils (100 mg) at 0 C. After 10 min. a solution of sodium nitrite (483 mg, 7 mmc ; in water (3 ml) was added dropwise at 5 C. The reaction mix- ture was stirred additionally 30 min. at 0°C. Aqueous so¬ dium hydroxide (2 N) was added to alkaline pH and the mix¬ ture extracted with ether. The ether phases were dried and evaporated to give a mixture of the title compounds. Separation by column chromatography (Si0 2 , eluent: ethyl acetate) gave the chloro compound, upper spot, in 230 mg yield. E. 3-(3-phenylpropylthio-l,2, 5-oxadiazol-4-yl)pyridine Sodium hydrogen sulfide monohydrate (0.74 g, 10.5 mmol) was added to a solution of 3-(3-chloro-l, 2, 5-oxadiazol-4- yl)pyridine 1.27, 7.0 mmol) in DMF (30 ml) at room tempe- rature and the reaction mixture was stirred for 1 h. Po¬ tassium carbonate (2.0 g, 14.5 mmol) and l-bromo-3-phenyl- propane (2.4 g, 12 mmol) were added and the reaction mix¬ ture was stirred for additionally 24 h. V.'ater (50 ml) was added and extracted with ether. The combined ether phases were dried and evaporated. Purification by column chroma¬ tography (SiO„, eluent: ethyl acetate / metr.ylene chloride (1:1)) gave the title compound. F. 3-(3-Phenylpropylthio-l ,2, 5-oxadiazol-4-y i-l-methyl- pyridiniu iodide Methyl iodide (1 ml, 15 mmol) was added to a solution of 3-(3-phenylpropylthio-l, 2, 5-oxadiazol-4-yl )pyridine (7 mmol) in acetone and the reaction mixture was stirred at room temperature for 20 h and evaporated. G. 3-(3-Phenylpropylthio-l,2, 5-oxadiazol-4-yl )-i, 2, 5, 6- tetrahydro-1-methylpyri ine oxalate Sodium borohydride (650 mg, 17 mmol) was added to a solu- tion of 3-(3-phenylpropylthio-l,2,5-oxadiazol-4-yl)-l- methylpyridinum iodide (7 mmol), in ethanol (99.9%, 20 ml) and the reaction mixture was stirred at -10 C for 1 h. After evaporation the residue was dissolved in water and extracted with ethyl acetate. The dried organic phases were evaporated and the residue purified by column chroma¬ tography (Si0 2 , eluent: ethyl acetate/methanol (4:1)). The title compound was crystallized as the oxalate salt from acetone and recrystallized to yield 170 mg. M.p. 106-108°C. Compound 47. The following compound was made in exactly the same manner using the appropriate alkylhalogenide: 3-(3-Phenoxyethylthio-l,2,5-oxadiazol-4-yl)-l,2,5,6-tetra- hhyydcro-1-methylpyridine oxalate, m.p. 122-124 C. Compound 48.

Claims: CLAIMS A compound of formula I 2 wherein Z independently is oxygen or sulphur; R is R , R 2 ZR 3 , R 2 C0-,R 2 C0R 3 , -CO-, R 2 C0 2 ~, R 2 C0 2 R 3 , -C0 2 -, -CONH-, R 2 CONH- , R 2 CONHR 3 or R 2 NHCONH 2 wherein R 2 and R 3 indepen¬ dently are straight or branched C. _. ,,-alkyl, straight or branched C 2 _. c .-alkenyl / or straight or branched 2 _. --al- kynyl, substituted with one to three halogens,~CF 3 , -OH , -CN, -CHO, -N0 2 , -C0 2 R 2 , -SOR 2 , -S0 2 R 2 , -CH=N0R 2 , -NR 2 R 3 , one or two phenyl, phenoxy, benzoyl or benzyloxycarbonyl groups optionally substituted with halogen, -CN, C. .-al¬ kyl or C. ,-alkoxy, or a 5 or 6 me bered heterocyclic group containing one to three N, 0 or S atom(s) or a com¬ bination thereof being saturated, partly saturated or aro¬ matic; R is H, straight or branched C. ( .-alkyl, straight or branched C ;? _ t --alkenyl, or straight or branched c 2 -5- alkynyl, or a salt thereof with a pharmaceutically- acceptable acid. 2. A compound according to claim 1 selected from the following: 3-(3-(4-Cyanopentylthio)-l,2, 5-thiadiazol-4-yl )-l, 2, 5, 6- tetrahydro-1-methylpyridine, 3-(3-(3-Chloropropylthio)-l,2,5-thiadiazol-4-yl)-l,2,5,6- tetrahydro-1-methylpyridine, 3-(3-(3-Cyanopropylthio)-1,2, 5-thiadiazol-4-yl)-1,2,5,6- tetrahydro-1-methylpyridine, 3-(3-(3-Phenylpropylthio)-1,2, 5-thiadiazol-4-yl)-1,2, 5, 6- tetrahydro-1-methylpyridine, 3-(3-(2-Phenoxyethylthio)-1,2,5-thiadiazol-4-yl)-1,2, 5,6- tetrahydro-1-methylpyridine, 3-(3-(4-Cyanobutylthio)-1,2, 5-thiadiazol-4-yl )-1, 2,5, 6- tetrahydro-1-methylpyridine, 3-(3-(8-Hydroxyoctylthio)-l,2,5-thiadiazol-4-yl)-l,2, 5, 6- tetrahydro-1-methylpyridine, 3-(3-(4-Chlorobutylthio)-l,2, 5-thiadiazol-4-yl )-l, 2, 5, 6- tetrahydro-1-methylpyridine, 3-(3-( 4, 4-Bis-(4-fluorophenyl )-butylthio)-l, 2, 5-thiadiazol- 4-yl )-l,2, 5, 6-tetrahydro-1-methylpyridine, 3-(3-(2-(l,3-Dioxolane-2-yl)-ethylthio)-l,2, 5-thiediazol- 4-yl)-l,2, 5, 6-tetrahydro-1-methylpyridine, 3-(3-(4-Cyanobenzyl hio)-l, 2, 5-thiadiazol-4-yl )-i, 2, 5, 6- tetrahydro-1-methylpyridine, 3-(3-(2-Phenylethylthio)-l,2, 5-thiadiazol-4-yl )-l, 2, 5, 6- tetrahydro-1-methylpyridine, 3-(3-(4-Bromobenzylthio)-l, 2, 5-thiadiazol-4-yl )-l, 2, 5,6- tetrahydro-1-methylpyridine, 3-(3-(4-Methylbenzylthio)-1,2,5-thiadiazol-4-yl)-1,2, 5,6- tetrahydro-1-methylpyridine, 3-(3-(4-Pyridylmethylthio)-l,2,5-thiadiazol-4-yl)-l,2,5,6- tetrahydro-1-methylpyridine, 3-(3-Benzoylethylthio-l,2,5-thiadiazol-4-yl)-1,2, 5,6- tetrahydro-1-methylpyridine, 3-(3-(4-0x0-4-(4-fluorophenyl)-butylthio)-1,2, 5-thiadia- zol-4-yl)-l,2,5,6-tetrahydro-l-methylpyridine, 3-(3-Benzyloxycarbonylmethylthio-l,2,5, 6-thiadiazol-4-yl - 1,2,5,6-tetrahydro-l-methylpyridine, 3-(3-Benzylthio-l, 2, 5-thiadiazol-4-yl)-l,2, 5, 6-tetrahydro- -1-methylpyridine, 3-(3-(4,4,4-Trifluorobutylthio)-l,2, 5-thiadiazol-4-yl )- 1,2,5,6-tetrahydro-l-methylpyridine, 3-(3-( 5, 5, 5-Trifluoropentylthio)-l, 2, 5-thiadiazcl-4-yl i- 1,2,5,6- tetrahydro-1-methylpyridine, 3-(3-(6, 6, 6-Trifluorohexylthio)-l,2, 5-thiadiazol-4-yl > - 1,2,5, 6-tetrahydro-l-methylpyridine, 3-(3-Ethoxycarbonylpentylthio)-l, 2, 5-thiadiazcl-4-yl )- 1,2,5, 6-tetrahydro-l-methylpyridine, 1,2,5,6-Tetrahydro-l-methyl-3-(3-(6, 6, 6-trifluorohexyloxy- 1,2,5-thiadiazol-4-yl)pyridine, 1,2,5,6-Tetrahydro-1-methyl-3-(3-(3-(2-thienyl )-l-pro- poxy)-l,2,5-thiadiazol-4-yl )-pyridine, 1,2,5,6-Tetrahydro-l-methyl-3-(3-(3-(4-methoxyphenyl)-l- propoxy)-l,2,5-thiadiazol-4-yl)-pyridine, 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-(4-methoxyphenyl)-1- ethoxy)-l,2,5-thiadiazol-4-yl )-pyridine, 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-(2-thienyl)-l-ethoxy) • 1,2,5-thiadiazol-4-yl)-pyridine, 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-(3-thienyl)-1-ethoxy)- 1,2,5-thiadiazol-4-yl)-pyridine, 1,2, 5, 6-Tetrahydro-l-methyl-3-(3-(3-hydroxy-l-propoxy)- 1,2,5-thiadiazol-4-yl)-pyridine, l,2,5,6-Tetrahydro-l-methyl-3-(3-(2-phenyl-l-ethoxy)- 1,2,5-thiadiazol-4-yl)-pyridine, 1,2,5, 6-Tetrahydro-1-methy1-3-(3-(2-thienylmethoxy)- 1,2, 5-thiadiazol-4-yl )-pyridine, 1,2,5, 6-Tetrahydro-1-methy1-3-(3-(3-hydroxy-l-hexyloxy)- 1,2, 5-thiadiazol-4-yl)-pyridine, 1,2,5, 6-Tetrahydro-l-methyl-3-(3-(3-thienylmethoxy)- 1,2, 5-thiadiazol-4-yl )-pyridine, 1,2,5, 6-TetrahydrQ-l-methyl-3-(3-(3-phenyl-l-propoxy)- 1,2, 5-thiadiazol-4-yl )-pyridine, l,2,5,6-Tetrahydro-l-methyl-3-(3-(3-(l-(2-pyrrolidone) )- 1-propoxy)-l,2,5-thiadiazol-4-yl)-pyridine, 1, 2,5, 6-Tetrahydro-l-methyl-3-(3-(6-acetamido-l-hexyl- oxy)-l, 2, 5-thiadiazol-4-yl )-pyridine, l,2,5,6-Tetrahydro-l-methyl-3-(3-(2-acetamido-l-ethoxy)- 1,2,5-thiadiazol- -yl)-pyridine, 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-( 1-( 2-pyrrolidinone) ) • 1-ethoxy)-l,2,5-thiadiazol-4-yl )-pyridine, 1,2,5,6-Tetrahydro-l-methyl-3-(3-(2-propionamido-l- ethoxy)-l,2,5-thiadiazol-4-yl )-pyridine, 1,2,5, 6-Tetrahydro-l-methyl-3-(3-(2-(3-(2-oxazolidone) )- 1-ethoxy)-1,2,5-thiadiazol-4-yl)-pyridine, 1,2, 5, 6-Tetrahydro-l-methyl-3-(3-(2-benzylthio-1-ethoxy)- l,2,5-thiadiazol-4-yl)-pyridine, 1,2, 5,6-Tetrahydro-l-methyl-3-(3-(3-( 1-pyrrolidyl )-l- propoxy)-l, 2, 5-thiadiazol-4-yl )-pyridine, 1,2,5, 6-Tetrahydro-l-methyl-3-( 3-( 2-carbamoyl-l-ethoxy )- 1,2, 5-thiadiazol-4-yl )-pyridine, 1,2,5, 6-Tetrahydro-1-methyl-3-( 3-( 2-( 1-ethy s lfoxido - 1-ethoxy)-l, 2, 5-thiadiazol-4-yl )-pyridine, 1,2,5, 6-Tetrahydro-3-(3-( 2-hexanone ) )-l, 2, 5-thiadiazol- 4-yl )-1-methylpyridine, 3-(3-Phenylpropylthio-l,2, 5-oxadiazol-4-yl ι-l, 2, 5, 6-tetra¬ hydro-l-methylpyridine, 3-(3-Phenoxyethylthio-l, 2, 5-oxadiazol-4-yl )-l, 2, 5, 6-tetra¬ hydro-l-methylpyridine, or salts thereof with pharmaceutically-aeceptable acids. 3. A method of preparing the compounds according to claim 1, which comprises alkylating a compound having the for- mula II wherein Z and R have the meanings defined above, with an alkyl halide and reducing the compound thus formed with hydride ions to form a compound having the formula I wherein Z, R and R have the meanings defined above. 4_^ A pharmaceutical composition comprising a compound of formula I wherein Z independently is oxygen or sulphur; straight or branched C-_. t --alkenyl, or straight or branch¬ ed C 2 _ lt --alkynyl, substituted with one to three halogens, CF 3 , -OH-, -CN, -CHO, -N0 2 , -C0 2 R 2 , -SOR 2 , -S0 2 R 2 , -CH=N0R , -NR R , one or two phenyl, phenoxy, benzoyl or benzyloxycarbonyl groups optionally substituted with halo- gen, -CN, C. .-alkyl or C.. .-alkoxy, or a 5 or 6 membered heterocyclic group containing one to three N, 0 or S atom(s) or a combination thereof being saturated, partly saturated or aromatic; R is H, straight or branched C. _- alkyl, straight or branched C 2 _,--alkenyl, or straight or branched C 2 _ ς - alkynyl, or a salt thereof with a pharma¬ ceutically-aeceptable acid together with a pharmaceuti- cally-acceptable carrier or diluent. 5. A pharmaceutical composition suitable for use in sti¬ mulating the cognitive functions of the forebrain and hippocampus of mammals, including humans, and in treating Alzherimer's disease, glaucoma or providing an analgesic effect, comprising an amount of a compound of formula I wherein Z independently is oxygen or sulphur; R is R 2, R 2 ZR 3 , R 2 CO-,R 2 C0R 3 , -CO-, R 2 C0 2 ~, R 2 C0 2 R 3 , -C0 2 ", -CONH-, R 2 C0NH- , R 2 CONHR 3 or R 2 NHCONH 2 wherein R 2 and R 3 indepen- dently are straight or branched C. __. ^ -alkyl, straight or branched C 2 _. ^ -alkenyl, or straight or branched C^ - ^ -al- kynyl, substituted with one to three halogens, CF_, -0H-, -CN, -CHO, -N0 2 , -C0 2 R 2 , -SOR 2 , -S0„R 2 , -CH=N0R 2 , -NR 2 R 3 , one or two phenyl, phenoxy, benzoyl or benzyloxycarbonyl groups optionally substituted with halogen, -CN, C. .-al¬ kyl or C- .-alkoxy, or a 5 or 6 membered heterocyclic group containing one to three N, 0 or S atora(s) or a com¬ bination thereof being saturated, partly saturated or aro¬ matic; R is H, straight or branched C. ^-alkyl, straight or branched C„_,-.-alkenyl, or straight or branched C~_ - - alkynyl, or a salt thereof with a pharmaceutically- aeceptable carrier or diluent. 6. A pharmaceutical composition according to claim 4 or 5 in the form of an oral dosage unit, or an parenteral dosage unit. 7. A pharmaceutical composition according to claim 4, 5 or 6, wherein said dosage unit comprises about 1 to about 100 mg of a compound of formula I or a salt thereof with a pharmaceutically-aeceptable acid. 8. A method of stimulating the cognitive functions of the forebrain and hippocampus comprising providing to a subject in need of such stimulation an effective amount of a compound of formula I wherein Z independently is oxygen or sulphur; R is R 2, R2ZR3, R2C0-,R2COR3, -CO-, R 2 C0 -, R 2 C0-,R 3 , -CO,-, -CONH-, R 2 CONH- , R 2 CONHR 3 or R 2NHCONH- wherein R2 and R3 independently are straight or branched C 1 _ 15 -alkyl, straight or branched C 2 _ 15 -alkenyl, or straight or branched C 2 _ 15 ~alkynyl, substituted with one to three halogens, CF 3 , -0H-, -CN, -CHO, -N0 2 , -C0 2 R , -SOR 2 , -S0 2 R 2 , -CH=N0R 2 , -NR 2 R 3 , one or two phenyl, phen¬ oxy, benzoyl or benzyloxycarbonyl groups optionally sub¬ stituted with halogen, -CN, C. .-alkyl or C. ,-alkoxy, or a 5 or 6 membered heterocyclic group containing one to three N, 0 or S atom(s) or a combination thereof being saturated, partly saturated or aromatic; R is H, straight or branched C j .-alkyl, straight or branched C__,--alkenyl, or straight or branched C- ^-alkynyl, or a salt thereof with a pharmaceutically-aeceptable carrier or diluent. 9. A method of treating Alzheimer's disease in a subject in need of such treatment, comprising providing to said subject an effective amount of a compound of formula I 2 wherein Z independently is oxygen or sulphur; R s R , R 2 ZR 3 , R 2 C0-,R 2 C0R 3 , -CO-, R 2 C0_,-, R 2 C0 R 3 , -CO--, -C0NH-, R CONH- , R CONHR or R NHC0NH 2 wherein R and R~ indepen¬ dently are straight or branched C. _.,--alkyl, straight or branched C- , ^-alkehyl, or straight or branched C__ 15 -al- kynyl, substituted with one to three halogens, CF,., -OH-, -CN, -CHO, -N0 2 , -C0 2 R 2 , -SOR 2 , -S0 2 R 2 , -CH=N0R 2 , -NR 2 R 3 , one or two phenyl, phenoxy, benzoyl or benzyloxycarbonyl groups optionally substituted with halogen, -CN, C, .-al- kyl or C. .-alkoxy, or a 5 or 6 membered heterocyclic group containing one to three N, 0 or S atom(s) or a co - bination thereof being saturated, partly saturated or aro¬ matic; R is H, straight or branched C. ,,-alkyl, straight or branched C„ ,,-alkenyl, or straight or branched C 2 _e- alkynyl, or a salt thereof with a pharmaceutically- aeceptable acid together with a pharmaceutically-aeceptable carrier or diluent. 10. A method of treating glaucoma comprising providing to a subject in need of such treatment an effective amount of a compound of formula I wherein Z independently is oxy¬ gen or sulphur; R is R 2 , R 2 ZR 3 , R 2 C0-,R 2 C0R 3 , -CO-, R 2 C0 2 -, R 2 C0 R 3 , -CO.,-, -C0NH-, R 2 CONH- , R 2 CONHR 3 or R 2 NHC0NH, wherein R 2 and R3 independently are straight or branched C, - 5 -alkyl, straight or branched C 2 _- 5 -alkenyl, or straight or branched C 2 _ 1( --alkynyl, substituted with one to three halogens, CF 3 , -0H-, -CN, -CHO, -N0 2 , -C0 2 R , -SOR 2 , -S0 2 R , -CH=N0R 2 , -NR 2 R 3 , one or two phenyl, phen- oxy, benzoyl or benzyloxycarbonyl groups optionally sub¬ stituted with halogen, -CN, C. .-alkyl or C, ,-alkoxy, or a 5 or 6 membered heterocyclic group containing one to three N, O or S atom(s) or a combination thereof being saturated, partly saturated or aromatic; R is H, straight or branched C, ^-alkyl, straight or branched C- ^ -alkenyl, or straight or branched C~_ - - alkynyl, or a salt thereof with a pharmaceutically- acceptable carrier or diluent. 11. A method of providing an analgesic effect comprising providing to a subject in need of such treatment an effec¬ tive amount of a compound of formula I wherein Z indepen¬ dently is oxygen or sulphur; R is R 2 , R 2 ZR , R CO-,R COR , -CO-, R 2 C0 2 -, R 2 CO_R 3 , -CO,,-, -C0NH-, R 2 C0NH- , R CONHR or R 2NHC0NH 2 wherein R2 and R3 independently are straight or branched C. .,_-alkyl, straight or branched C 2 _-, 5 -alke- nyl, or straight or branched C 2 _ 15 -alkynyl, substituted with one to three halogens, CF 3 , -0H-, -CN, -CHO, -N0 2 , -C0 2 R 2 , -SOR 2 , -S0 2 R 2 , -CH=N0R , -NR 2 R 3 , one or two phe¬ nyl, phenoxy, benzoyl or benzyloxycarbonyl groups option- ally substituted with halogen, -CN, C- .-alkyl or C, .- alkoxy, or a 5 or 6 membered heterocyclic group containing one to three N, O or S atom(s) or a combination thereof being saturated, partly saturated or aromatic; R is H, straight or branched C 1 _ 5 ~alkyl, straight or branched C 2 _ 5 -alkenyl, or straight or branched C 2 -- alkynyl, or a salt thereof with a pharmaceutically- acceptable acid to- 5 gether with a pharmaceutically-aeceptable carrier or di¬ luent. 12. A method of claim 8, 9, 10 or 11, wherein said compound is administered in the form of a pharmaceutical composition 10 together with a pharmaceutically-aeceptable carrier or di¬ luent. 13. A method of claim 8, 9, 10, 11 wherein said compound together with a pharmaceutically acceptable carrier or 15 diluent is administered in the form of an oral pharmaceu¬ tical dosage form. 14. A method of claim 8, 9, 10 or 11 wherein said compound " " together with a pharmaceutically-aeceptable carrier or di- 20 luent is administered in the form of a parenteral pharma¬ ceutical dosage form. 25 30 35

Inventors: MITCH CHARLES H, OLESEN PREBEN H, SAUERBERG PER, MITCH, CHARLES, H., OLESEN, PREBEN, H., SAUERBERG, PER
Applicants: NOVONORDISK AS, NOVO NORDISK A/S
Application year: 1991
Main classification: C07D417
IPC codes: A61K31, A61P25, A61P27, A61P43, C07D413, C07D417