VETERINARY TREATMENT

Abstract: A formulation comprising amoxycillin or a veterinarily acceptable derivative thereof, clavulanic acid or a veterinarily acceptable derivative thereof, and a veterinarily acceptable carrier is used in the treatment of farrowing fever and/or bacterial pneumonia in pigs.

Description: Veterinary Treatment This invention relates to a method for the treatment of bacterial infections in pigs, particularly those infections associated with farrowing fever and bacterial pneumonia. GB-B-2 005 538 describes a dry pharmaceutical composition, which comprises 20mg to 1500mg of amoxycillin trihydrate, 20mg to 500mg of potassium clavulanate and a pharmaceutically acceptable carrier, with the proviso that the weight ratio of amoxycillin trihydrate to potassium clavulanate is from 6:1 to 1:1. According to the present invention there is provided a method for the treatment of farrowing fever and bacterial pneumonia in pigs, which comprises administering to the animal an effective amount of amoxycillin or a veterinarily acceptable derivative thereof, clavulanic acid or a veterinarily acceptable derivative thereof, and a veterinarily acceptable carrier. A second aspect of the invention provides the use of a formulation comprising an effective amount of amoxycillin or a veterinarily acceptable derivative thereof, clavulanic acid or a veterinarily acceptable derivative thereof, and a veterinarily acceptable carrier in the manufacture of a medicament for use in the treatment of farrowing fever and bacterial pneumonia in pigs. The formulation has notable bactericidal activity against the bacteria associated with the diseases farrowing fever and bacterial pneumonia in particular SUBSTITUTE SHEET Actinobacillus pleuropneumoniae. Suitably the clavulanic acid used in the formulation is in the form of a veterinarily acceptable salt such as potassium clavulanate. Suitably the amoxycillin used in the formulation is in the form of the trihydrate or a veterinarily acceptable ester or salt of amoxycillin such as the sodium salt. The preferred weight ratio of amoxycillin or derivative to clavulanic acid or derivative is from 6:1 to 1:1. Advantageously, a liquid formulation of the invention comprises 36mg/ml clavulanic acid (as potassium clavulanate) and 140mg/ml amoxycillin (as amoxycillin trihydrate) . Preferred veterinarily acceptable carriers include for example veterinarily acceptable oils such as mineral oils or fractionated coconut oil such as Miglyol 840. Suitably the formulation is administered to the animal by intramuscular injection. The formulation is typically prepared as an off-white suspension and is presented as a 'Ready-To-Use' form, that is the formulation is preprepared and packed in a suitable container, wherein it is ready for administration to the animal in need thereof. The dosage rate will vary according to the size of the animal. A suitable dosage rate is generally between 2 and 25mg/kg bodyweight of the animal, for example about 8.75mg/kg. SUBSTITUTE SHEET Typically more than a single dose of the formulation will be required for the treatment of the bacterial infections, suitably one dose per day for 3 to 5 days is required. In cases of severe infections prolonged treatment may be required. Veterinary formulations for use in the present invention may be prepared by mixing the ingredients thereof in the required proportions. The formulation is then packaged into an appropriate container ready for administration. The following Example illustrates the invention. Formulation g/lOOml amoxycillin trihydrate 14.0 potassium clavulanate 3.6 phenol 0.5 iglyol 840 to 100ml SUBSTITUTESHEET Clinical data CASE STUDY 1 Naturally-occuring cases of farrowing fever in pigs were diagnosed on clinical grounds, then treated on an alternating basis with either Synulox* or a control drug. The control drug was a penicillin G/streptomycin mixture. Treatment was administered once daily for a minimum of 3 days. Synulox* was given at a dose rate of 1ml per 20kg of body weight. The clinical response to treatment was scored on a pre-defined scale: CRS 1 = excellent CRS 2 = food CRS 3 = fair CRS 4 * = poor (CRS = clinical response score) From the results which are summarised in FIG 1, it can be seen that Synulox* has good efficacy in the treatment of farrowing fever in pigs. SUBSTITUTE SHEET CASE STUDY 2 A total of 229 pigs with pneumonia caused by Actinobacillus (Haemophilus) pleuropneumonia were involved in this study. 156 pigs were treated with Synulox* and 73 were treated with a control drug, oxytetracycline (lml/kg body weight administered intramuscularly) . Synulox* was injected intramuscularly at a dose rate of lml/20kg body weight. Treatment was continued daily until clinical signs of cough, dyspnoea, anorexia and depression were remitted and clinical responses were stored on the basis of the number of treatments required to achieve remissision. Clinical response was scored as follows: CRS 1 = excellent CRS 2 = good CRS 3 = fair CRS 4 = poor The clinical response scores are summarised in FIG 2, wherein it was shown that of the total of 156 pigs treated with Synulox* 48.1% showed an ' 'excellent' ' response, 31.4% had a ''good'' response, 18.6% ''fair'' and only 1.9% ''poor'' against 35.6% of pigs treated with the control showing an ''excellent'' response 32.9%, ''good'', 31.5% ''fair'' and 0% ''poor''. It was therefore concluded that Synulox* has good efficacy in the treatment of bacterial pneumonia in pigs. * Synulox is a Trademark of Beecham Group p.I.e. Synulox is an oily suspension contining 35mg/ml clavulanic acid (K salt) and 140mg/ml amoxycillin (trihydrate) . SUBSTITUTE SHEET

Claims: Claims 1. The use of a formulation comprising an effective amount of amoxycillin or a veterinarily acceptable derivative thereof, clavulanic acid or a veterinarily acceptable derivative thereof, and a veterinarily acceptable carrier in the manufacture of a medicament for use in the treatment of farrowing fever and/or bacterial pneumonia in pigs. 2. A method for the treatment of farrowing fever and/or bacterial pneumonia in pigs, which comprises administering to the animal an effective amount of amoxycillin or a veterinarily acceptable derivative thereof, clavulanic acid or a veterinarily acceptable derivative thereof, and a veterinarily acceptable carrier. 3. A veterinary composition for the treatment of farrowing fever and/or bacterial pneumonia in pigs, which comprises an effective amount of amoxycillin or a veterinarily acceptable derivative thereof, clavulanic acid or a veterinarily acceptable derivative thereof, and a veterinarily acceptable carrier. 4. The use according to claim 1 wherein the clavulanic acid is used in the form of potassium clavulanate. 5. The use according to claim 1 or 4 wherein the amoxycillin is used in the form of the trihydrate or the sodium salt. 6. The use according to claim 1, 4 or 5 wherein the weight ratio of amoxycillin or derivative to clavulanic acid or derivative is from 6:1 to 1:1. SUBSTITUTE SHEET 7. The use according to claim 1, 4, 5 or 6 wherein the veterinarily acceptable carrier is an oil suitable for injection. SUBSTITUTE SHEET

Inventors: CRACKNELL VICTOR CHARLES, CRACKNELL, VICTOR, CHARLES
Applicants: BEECHAM GROUP PLC
Application year: 1991
Main classification: A61K31
IPC codes: A61K31, A61P15, A61P43