TREATMENT OF TOPICAL INFECTIONS

Abstract: A composition for use in topical treatment of infections of the skin, comprising a mixture of at least 0.5 % by weight of each of the following ingredients: an alkali metal carbonate; an alkali metal phosphate; and an alkali metal hypochlorite, in a pharmaceutically acceptable carrier. A method for using the composition is also disclosed.

Description: TREATME T OF TOPICAL INFECTIONS BACKGROUND OF THE INVENTION The present invention relates to a method and composition for treatment cf topical bacterial, viral, and fungal infections. It is particularly useful in treatment of cold sores, fever blisters, and other symptoms of herpes simplex I virus infection, as well as other topical infections such as impetigo and ringworm. There are many people who suffer occasionally or chronically from herpes simplex I, the common cold sore. Cold sores can appear on the lips, around- the rim of the mouth, in nostrils, around the rim of the nostrils, and on the upper lip between the nose and the mouth. A cold sore usually goes through a cycle. The onset i≤ characterized by stinging, vexing, burning, -an itching sensation, and swelling and rubification of the skin tissues in the afflicted area. Next comes the development of blisters and continued swelling. Blisters may break and weep. Finally the blisters begin to shrink and dry, followed by a scab covering. The scab covering is unsightly, as is the entire cold sore process, and even during the scab phase there are often onsets of burning, stinging, and itching. The course of the infection from onset to disappearance is usually about three weeks. Needless to say, ho one wants a cold sore. For those with high profile professions, such as sales personnel, entertainers, actors, and models, the affliction is more than a mere embarrassment; it can mean loss of work. Make-up car, cover the problem only partially. The present invention addresses this problem by providing a method and composition for treating and eliminating the effects of this viral infection. The composition used s a.-. antiviral and antibacterial material. SUMMARY OF THE INVENTION The compositions cf the present ir.veπticr. -τ.a_, advantageously comprise a mixture of a" least 1.5V by • .•.-ei-r. of each of the following ingredients: an alkali metal carbonate, preferably sodium carbonate or calcium carbonate; an alkali metal phosphate s„uch as sodium phosphate or calcium phosphate; and an alkali metal hypochlorite such as calcium hypochlorite. The balance up to 100% of the composition can be made up of pharmaceutically acceptable diluents, carriers, and excipients, such as corn starch, aloe vera lotion, silica, polysorbates r glycerine, alcohol, water, and the like. The composition is for use in topical treatment of skin infections and may be in the form of a dry powder, a lotion, cream, paste, or ointment. In- a preferred embodiment, the alkali metal carbonate comprises a mixture of calcium carbonate and sodium carbonate, most preferably in approximately equi olar amounts. The present invention also includes use of any of the foregoing compositions in the preparation of a medicament for treatment of a topical infection of the skin. The method of the present invention requires applying tne composition described herein to the site of a topical infection of the skin or mucous membranes, such as the site of a cold sore, impetigo, herpes eruption, ringworm, and the like ^ The composition is preferably applied as a paste or other spreadable composition having sufficient viscosity to remain localized on the affected area. The liquid vehicle used with the active ingredients is preferably volatile, sc that it can evaporate and leave a dry composition on the skin. This dry composition is believed to exert a drawing effect on the affected area, with therapeutic results. DETAILED DESCRIPTION OF THE INVENTION The present invention includes a blending of ingredients; active, inactive, cleaning agents and carrier τ where said ingredients can provide a treatment or cure for tnose suffering from symptoms of herpes simplex I, other topical herpes or viral infections, common cold sores and fever blisters,, ringworm, impetigo, .and other viral, fungal, snc bacterial infections of the ' skin. The compositions of the present . invention may. advantageously comprise a mixture of at least 0.5% by weight of each cf the following ingredients: an alkali metal carbonate, preferably sodium carbonate or calcium carbonate; an alkali metal phosphate such as sodium phosphate or calcium phosphate; and an alkali metal hypochlorite such as calcium hypochlorite. The balance up to 100% of the composition can be made up of pharmaceutically acceptable diluents, carriers, and excipients, such as corn starch, aloe vera lotion, silica, polysorbates, glycerine, alcohol, water, and the like. The composition may be in the form of a dry powder, a lotion, cream, paste, or ointment. In a preferred embodiment, the alkali metal carbonate comprises a mixture of calcium carbonate' and sodium carbonate, most preferably in approximately equimolar amounts. In one embodiment of the invention, the active ingredients of the composition are • present in the following weight ratios: Calcium carbonate 5-10 parts Sodium carbonate 5-10 parts Sodium phosphate (anhydrous) 5-10 parts Calcium hypochlorite 6-12 parts In another embodiment of the invention, the active ingredients are present in the following weight ratios: Calcium carbonate about 7 parts Sodium carbonate about 7 parts Sodium phosphate (anhydrous) about 7 parts Calcium hypochlorite about 8 parts In still another embodiment, the composition is a wettable powder with the following composition of active ingredients: Calcium carbonate (CaC0 3 ) 1.4% Sodium carbonate (Na 2 C0 3 ) 1.4% Sodium phosphate (Na,HP0 4 ) 1.4% (anhydrous. Calcium hypochlorite (Chlorinol) 1.8% The remainder c: tnis particular ormulation ~ .a y ;:e - . wettable excipier.t, sucn as corn starch, modifiec: ::C ctarc:.. fumed silica, and the like. In any of the compositions, the formulation can als comprise inert ingredients such as corn starch, for blendin consistency and control of dosage strength, and blendin ingredients, such as aloe lotion, for texture, color, an aroma, in such proportions as desired. In the practice of the present invention, the dr formulation described above in the Summary of the Invention i combined with water and is applied to the site of the of th infection as a paste. The formulation acts as a cleanin drawing agent as said paste dries. Most importantly, th combination of ingredients effectively kills or render harmless any active virus of the herpes simplex strain. Whe applied to a suspected cold sore patch the compound will firs clean the area, second draw the fluids of the weeping lesion or watery blisters into the paste and finally the antisepti qualities of the compound will kill' all viruses and bacteri present. The result is the cold sore is immediately relieved o the. vexing pain, stinging and burning sensations common wit cold sores. Not only is the pain and discomfort eliminate quickly, but the cold sore itself and the colony of virus which caused the eruption in the first place is eradicated. The sufferer will have the pain vanquished and the cold sore will not erupt later with the unsightly weeping lesions and later scabs. Cold sores will quickly disappear as soon as the application of the remedy is made and they will not reoccur. By using the compound of the invention, a user can eliminate the initial discomfort and unsightliness of the usual . three week period onset, eruption and final healing cf a cold " sore. The purpose of the invention is to provide a home remedy which is simple to use and effective against herpes simplex I, the common cold sore, and the other indications mentioned above. The composition should not be taken internally. The present invention solves the proπxer. c: nerpe-f simplex I, cold sores, quickly and permanently. Ir. one - D- preferred embodiment, the ingredients remain dry and ready for use until water is added to form a light paste. When applied, the chemicals first clean the area, next they begin killing cf the virus causing the irritation. As the paste dries, it has a drawing effect. This drawing effect will pull the fluid of the weeping lesion into the paste. The most contagious stage is blunted because the fluid containing the virus is pulled into the paste and killed. At any stage, the compound will be effective against cold sores. Almost instant relief from the horrendous cold sore is achieved. Repeat or continued applications are not necessary as the virus causing the inflammation is killed, leaving the natural body action to take over and return the affected cells to normal. Although certain preferred embodiments are described, it will be apparent that various modifications, changes, different excipients, and the like can be readily made without departing from the spirit of the invention. Thus, it is intended that the scope of the present invention be measured by the appended claims and their reasonable equivalents.

Claims: WHAT IS CLAIMED IS; 1. A composition packaged for use in the treatment of topical infections of the skin, comprising a mixture of at least 0.5% by weight of each of the following ingredients: an alkali metal carbonate; an alkali metal phosphate; and an alkali metal hypochlorite, in a pharmaceutically acceptable carrier. 2. The composition of Claim 1, wherein the alkali metal carbonate comprises a mixture of calcium carbonate and sodium carbonate. 3. The composition of Claim 1, wherein the active ingredients are present in the following weight ratios: Calcium carbonate 5-10 parts Sodium carbonate 5-10 parts Sodium phosphate (anhydrous) 5-10 parts Calcium hypochlorite 6-12 parts 4. The composition of Claim 1, wherein the active ingredients are present in the following weight ratios: Calcium carbonate about 7 parts Sodium carbonate about 7 parts Sodium phosphate (anhydrous) about 7 parts Calcium hypochlorite about 8 parts 5. The composition of Claim 1, further comprising sufficient corn starch to provide blending consistency. 6. The composition of Claim 1, further in combination with aloe lotion. 7. Use of the composition of any one of Claims 1-6 in the preparation of a medicament for treatment of infections of the skin. , 8. - A method for topical treatment of infections cf the skin, comprising applying a composition according to any one of Claims 1 to 6 to the site of the infection. 9. The method of Claim 8, wherein said infection is herpes simplex I. 10. The method of Claim 8, wherein the composition is applied in. the form of a drying paste. 11. The method of Claim S, wherein the infection is ringworm.

Inventors: FLOWERS MARIANNE, TAVARES BASILIO, FLOWERS, MARIANNE, TAVARES, BASILIO
Applicants: FLOWERS MARIANNE, TAVARES BASILIO, FLOWERS, MARIANNE, TAVARES, BASILIO
Application year: 1991
Main classification: A61K33
IPC codes: A61K33, A61K36, A61P31