SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY

Abstract: The invention relates to bicyclic aryl compounds having selective LTB4 antagonist properties and comprising an amido substituent , a substituent group having a terminal carboxylic acid or derivative thereof and a lipophilic substituent, and to methods for the treatment of disorders which result from LTB4 activity and pharmaceutical compositions including such compounds.

Description: SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY Background of the Invention This application is a continuation-in-part application of U.S. Serial No.07/580,243 filed on September 10, 1990. Field of the Invention The present invention relates to a class of novel compounds useful in the treatment of a variety of diseases that involve undesirable inflammatory or hypersensitivity responses in diverse animal tissues. Approaches to the treatment of these responses have been as varied as the tissues in which such responses take place, and include the administration of antihistamines, analgesics such as aspirin, topical coal tar as well as others. A more recent approach to the moderation of inflammatory and hypersensitivity responses has focused on Mocking the action of arachidonic acid metabolites (including the prostaglandins), lipoxygenases and the leukotrienes. The leukotrienes (LT) metabolites are formed by oxygenation of a lipoxygenase (5-hydroperoxy-tetraenoic acid (5-HPETE)) which is formed by the specific oxygenation of the C-5 position of arachidonic acid. The first leukotriene formed in the metabolic pathway is the unstable epoxide intermediate leukotriene A4 (LTA4) which is the precursor to the family of peptido-leukotrienes, the first in the pathway being LTC4 which is formed by glutathione addition. LTC4 is transformed subsequently into LTD4 and LTE4 by successive elimination of a glutamyl and glycine residue. The peptido- leukotrienes primarily act on smooth muscle and other cells having contractile capacity, as well as playing a key role in hypersensitivity reactions. In addition, the peptido-leukotrienes are spasmogens, increase vascular permeability, activate airway smooth muscle, stimulate mucous secretion and are involved with the pathogenesis of certain inflammatory diseases such as bronchitis, ectopic and atopic eczema and psoriasis. Leukotrienes appear to be involved in the pathogenesis of asthma such as allergic pulmonary disorders of asthma, hay fever and allergic rhinitis. In addition, LTC4, LTD4 and LTE4 may also decrease blood pressure by an action on the heart, because they reduce myocardial contractility and coronary blood flow. Another family of leukotrienes, LTB4, is derived from LTA4 by hydrolase- catalyzed addition of water. This 5,12-dihydroxy derivative causes adhesion and chemotactic movement of leukocytes, stimulates aggregation, enzyme release and generation of superoxide in neutrophils. Additionally, LTB4 is a potent chemotactic and chemokinetic agent for eosinophils, macrophages and monocytes, stimulates suppressor T lymphocytes and enhances natural cytotoxic cell activity. LTB4 is also a potent (indirect) bronchoconstrictor but in contrast to the peptido-leukotrienes C4, D4 and E4 does not appreciably stimulate mucous production and induce edema of the airways by increasing vascular permeability. Reported Developments It has been suggested that compounds antagonizing LTB4 activity may be valuable in the treatment of inflammatory diseases caused by tissue degrading enzymes and reactive chemicals liberated by tissue-infiltrating and aggregating polymorphonuclear leukocytes. Such disease states include inflammatory bowel disease, reperfusion injury, chronic lung diseases, various arthritic conditions, inflammatory conditions associated with asthma (such as late phase hypersensitivity) and psoriasis. The literature reports a variety of compounds exhibiting leukotriene B4 antagonist activity. These include compounds having chemical structures mimicking leukotriene structures such as Sumitomo's SM 9064, UpJohn's U-75360 and U-75302 and Ciba Geigy's CGS 23113. Other compounds, some of which include monocyclic ring structures and which are disclosed in EP 276064, EP 276065 and EP 292977, are reported to exhibit both LTD4 and LTB4 antagonist properties. The present invention is directed to a class of novel bicyclic ring containing compounds which exhibit selective LTB4 antagonist activity. Summary of the Invention This invention relates to compounds having LTB4 antagonist properties and to therapeutic compositions and methods for the treatment of disorders which result from LTB4 activity. In general, this invention comprises bicyclic aryl compounds having selective LTB4 antagonist properties and comprising an amido substituent, a substituent group having a terminal carboxylic acid or derivative thereof and a lipophilic substituent. Detailed Description and Preferred Embodiments As employed above and throughout this disclosure, the following terms, unless otherwise indicated, shall be understood to have the following meanings: "Bicyclic aryl" means a bicyclic ring system composed of two fused rings which may be partially or completely unsaturated carbocyclic and/or heterocyclic rings. Preferred bicycles include naphthalene, indole, benzothiophene, benzofuran, quinoline, chromone and purine. "Monocyclic aryl" means a partially or completely unsaturated carbocyclic or heterocyclic ring. Preferred monocycles include benzene, thiophene, pyridine, furan and pyrimidine. "Aryl" refers to a partially or completely unsaturated carbocyclic or heterocyclic aromatic ring. "Alkyl", either alone or with various substituents defined herein, means a saturated aliphatic hydrocarbon, either branched- or straight-chained. A "loweralkyl" is preferred having about 1 to about 6 carbon atoms. Examples of alkyl include methyl, ethyl, n-propyl, isopropyl, butyl, sec-butyl, t-butyl, amyl and hexyl. "Alkoxy" refers to a loweralkyl-O-group. "Alkenyl" refers to a hydrocarbon having at least one point of unsaturation and may be branched- or straight-chained. Preferred alkenyl groups have 2 to about 6 carbon atoms present. Exemplary alkenyl groups include vinyl, allyl, ethynyl and isopropenyl. The preferred aryloxy group is phenoxy. "Aralkyl" means an alkyl group substituted by an aryl radical. The preferred aralkyl groups are benzyl or phenethyl. The preferred aralkoxy groups are benzyloxy and phenethoxy. "Halo" means a halogen. Preferred halogens include chloride, bromide and fluoride. The preferred haloalkyl group is trifluoromethyl. More specifically, the bicyclic 6,6 and 6,5 aryl ring systems are preferred. These are described by formulae I and II where T, U, V and W and T, U', V * and W are selected from CRi R2, NR3, O and S provided that each ring of said bicyclic systems contain 0-2 hetero atoms and said hetero atoms are not vicinal oxygen and/or sulfur atoms; X and Z are independently CR1 R2, NR3, O or S; Y is CR-| R2 or NR3; and Rl is hydrogen, alkyl or together with a vicinal R1 may form a carbon- carbon double bond or together with a vicinal R3 may form a carbon-nitrogen double bond. R-| , R2 and R3 are further described below. Preferred bicyclic ring systems include indene, isoindene, benzofuran, benzothiophene, indole, 1 H-indazole, indoline, benzopyrazole, benzoxazole, purine, naphthalene, tetralin, coumarin, chromone, quinoline, isoquinoline, quinazoline, pyrido[3,4-b]pyridine and 1 ,4-benzisoxazine. Still more preferred compounds are described by Formula II where T, U, V and W are CRi R2 or NR3 and T+U+V+W contain no more than 2 NR3 groups. Turning now to the three substituents which are necessarily attached to the bicyclic ring system, the preferred first substituent, which we have called the amido function, may be described by formula III: R O R 1 II I A- (C) a — C -N (C) b — B R R' R Formula III The preferred second substituent having a terminal carboxylic acid or derivative thereof may be described by formula IV: R R 1 I — (C) d -D (C) β — E R R Formula IV The preferred third substituent, the lipophilic substituent, may be described by formula V: R R l I - (C), - — <C) g -G R R Formula V where A, B, D, E, F, G, R, R', a, b, d, e, f and g are as described below. These above substituents of formulae III to V may be attached at various positions of the bicyclic ring system and therefore they form part of the definition for both R2 and R3 and could be present at such sites of the bicyclic ring systems defined as CRi R2 or NR3. When R2 and R3 are neither substituent described by Formulae III to V, R2 may further be selected from hydrogen, alkyl, alkenyl, aryl, aralkyl, alkoxy, aryloxy, aralkoxy, amino, mono- and di-alkylamino, mercapto, alkylthio, aralkylthio, nitro, halo or haloalkyl; geminal R1 and R may be =0; and R3 may further be selected from hydrogen or alkyl. The following definitions apply to the substituents of formulae III to V, each of which is attached at a suitable position on the bicyclic ring, where: A is -CRR, O, S, NR', SO or SO2; B and G are each independently a substituted or unsubstituted monocyclic or bicyclic aryl; D and F are each independently a bond O, S, NR', SO, SO2, CONR', NR'CO, - CRR, -0-(CRR)j-, -(CRR)j-O-, -0-(CRR)j-CR=CR-, -CR=CR-(CRR)j-0- where j is 1-4 or (CR=CR) X where x is 0-2 or C≡C; -CON (CH 2 ) y E is -COOR', -CONR'R', ^^ , where y is 2-5, -CN, -CONHS02R', or substituted tetrazolyl where the substituent is alkyl, carboxyalkyl or carbalkoxyalkyl; R is independently hydrogen or -(CH2)m-R2 where m is 0-5 or together with a vicinal R group or vicinal R' group forms a 4-7 membered ring which may be saturated or partially unsaturated; R' is hydrogen, alkyl or aralkyl; and a, b, d, e, f and g are 0-4 provided d+f+g+x≠O. The most preferred compounds of this invention are described by those compounds of formula II where: X, Y and Z are CRi R2 or NR3 provided at least one of X, Y and Z is CR1 R2; T, U, V and W are CRi R2 or NR3 provided at least two of T, U, V and W are CR-| R2; R1 is hydrogen or together with a vicinal R1 may form a carbon-carbon double bond or together with a vicinal R3 may form a carbon-nitrogen double bond; R2 and R3 are independently hydrogen, and at least one of R2 and R3 is R O R I II I A- (C) fl — C -N (C) b — B R R' R , at least another of R2 or R3 is R R I (C) d -D ■ (C). — E and at least one other of R2 and R3 is R R I I - (C) f -F (C) g -G R R ; where A, B, D, E, F, G, R, R', a, b, d, e, f and g are as described above; and pharmaceutically acceptable salts thereof. B and/or G may be optionally substituted with 1 to about 3 R" groups where R" is alkyl, haloalkyl, alkoxy, halo or nitro. A special embodiment of this invention encompasses the compounds of formulae Via and Vlb. Formula Via Formula Vlb where at least one of R4, R5, Re, R7. Rδ. R9 and R10 and R11, R12, R13. R14. R O R I II I A- (C) β -—C -N (C) b — B R15- 16. 17 and Ri 8 are R R' R ; at least one of R4, R5. R6. R7, Rδ, R9 and RlO and R11. R12, R13, R14, R15, R16, Rl7 and R18 ϊ ? — (C) d -D (C) β — E are R R ; and at least one of R4, R5, R6, R7, Rδ, R9 and R10 and Rι ι , Ri2, R13, R14, R15, R16, Rl7 and Riδ R R - (C) f -F — (C) g -G R R and the remaining R4, R5, RQ, R7, Rs, Rg, R10, Ri 1 , R12. R13, R14, R15, R16, R 17 and Ri 8 groups are hydrogen and where: A is -CRR or O; B and G are independently phenyl or substituted phenyl where the substituents are alkyl, haloalkyl, alkoxy or halo; D is a bond, O, -CRR, -0-(CRR) j -, -(CRR) j -O-, -0-(CRR) j -CR=CR-, - CR=CR-(CRR) j -0- where j is 1-4 or -(CR=CR)χ where x is 1 or 2; -CON (CH 2 k E is -COOR', -CONR'R', >*^ where y is 2-5, -CN, -CONHS02R', tetrazolyl or substituted tetrazolyl where the substituent is alkyl, carboxyalkyl or carbalkoxyalkyl; F is a bond, O, -CRR, -NR' -(CR=CR)χ where x is 0-2; R is hydrogen or -(CH2)m-R2 where m is 0-5; R2 is hydrogen, alkyl, alkenyl, phenyl, alkoxy, amino, mono- and di- alkylamino, mercapto, alkylthio, halo or haloalkyl; R' is hydrogen, alkyl or aralkyl; and a, b, d, e, f and g are independently 0-4. The preferred positions for substitution in the indole molecule of formula VI are the 1 , 3, 4 and 5 positions, and the more preferred aspect of this special embodiment includes those compounds where: A is CHR or O; B and G are phenyl or substituted phenyl where the substitutents are loweralkyl or loweralkoxy; D is a bond, O, -CHR, -0-(CRR)j-, -(CRR) j -O-, -0-(CRR) r CR=CR-, -CR=CR-(CRR) j -0- where j is 1-4 or (CR=CR) X where x is 1 or 2; E is -COOR" or tetrazolyl; F is a bond, O or -CHR; R is hydrogen, loweralkyl or aryl; R' is hydrogen, loweralkyl or arloweralkyl; and a, b, d, e, f and g are independently 0-4. Among the most preferred amido substituents are: where R' is hydrogen or lower alkyl and R" is hydrogen, lower alkyl or lower alkoxy. Among the most preferred terminal acidic substituents are: -(CRR)d-(CRR)e-E where d and e are 0-4, -(CR=CR) X -E where x is 1-2, -0-(CRR)j-(CRR) Θ -E where j and e are 1-4, -0-(CRR)j-CR=CR-E where j is 1-4 *^ N <? ~< II -. N N and R is hydrogen or lower alkyl and E is -COOH or H Among the most preferred lipophilic substituents are: where g is 0-4 and R is hydrogen or lower alkyl and R" is hydrogen, lower alkyl or lower alkoxy. While this invention necessitates the presence of three substituents attached to the bicyclic ring system as described by formulae III to V, it is often desirable to have a fourth substituent present. This may be the same or different as these already present or it may also be derived from formulae III to V. Other substituents may likewise be desired. It is to be understood that such compounds fall within the scope of this invention. It may be of interest to one skilled in the art that compounds where E is OR' may also be of value as LTB4 antagonists. The compounds of this invention may be prepared by employing art recognized procedures from known compounds or readily preparable intermediates. Exemplary general procedures are as follows: Since the compounds of this invention have three substituents which are necessarily present, the introduction of each substituent to the aryl ring system is, of course, dependent on the specific substituents involved and the chemistry necessary for their formation. Thus, consideration of how one substituent would be affected by a chemical reaction when forming a second substituent would involve techniques familiar to the skilled artisan. This would further be dependent on the bicyclic ring system involved. It is convenient to synthesize these molecules by employing condensation reactions at reactive A, D and F cites of the molecule. Exemplary general procedures are as follows and are shown for convenience using the indole ring system. Of course, while the following reactions involved are basic to developing indole molecules having the three required substituents present, the substitution patterns for other bicyclic rings, such as napthalene, would depend on the chemistry of the particular ring. Any such adjustments to the chemistry would be familiar to one skilled in the art. Thus, in order to prepare those compounds where A, D or F is O, S or NR' the following reactions or combination of reactions may be employed: B When A, D or F is O or S, the compounds may be prepared by condensation of a bicyclic aryl alcohol or thiol with a compound of the formulae R O R' R L-(C) a -C-N-(C) b -B L-(C) d -D-(C) e -E L-(C) f -F-(C) g -G R R , R R or R R , where E is preferably a nitrile, ester or tetrazole and L is a leaving group such as halo, tosylate or mesylate. This reaction is usually carried out in the presence of any base normally employed to deprotonate an alcohol or thiol such as sodium hydride, sodium hydroxide, triethyl amine, sodium bicarbonate, diisopropyl/ethylamine or methyl magnesium halides. Reaction temperatures are in the range of room temperature to reflux and reaction times may vary from 2 to 96 hours. The reaction is usually carried out in a solvent that will dissolve both reactants and is inert to both as well. Solvents include, but are not limited to diethyl ether, THF, N,N-dimethyl formamide, dimethyl-sulfoxide, dioxane and the like. When A is an alkyl group, it is convenient to prepare these compounds by Friedel-Crafts alkylation or by the Wittig reaction followed by reduction. In the case where A, D or F is SO or SO2, then treatment of the thio compound with m-chlorobenzoic acid or sodium periodate results in the sulfinyi compound. Preparation of the sulfonyl compound may be accomplished by known procedures such as dissolving the sulfinyi compound in acetic acid and treating with 30% H2O2. R R I I Those compounds where F and/or D are " (C-C) x " where x is 1 or 2, are prepared by reacting the appropriate aldehyde or ketone with an appropriate Wittig reagent or modified Wittig reagent of the formula O R R T I I EtO, - P - C - (C) Q - G H I R I where E is cyano or carbalkoxy. Thus for example and yields Reference for the Wittig reaction and modified Wittig reaction to control the formation of the trans and cj£ configuration at the double bond and the isomerization of cj≤ and trans isomers can be found in A. Maercher, Organic Reactions. 14, 270,1965. The intermediate aldehyde compounds may be prepared in the usual manner from the corresponding carboxylic acid with an alkylithium reagent, or from the oxidation of the corresponding alcohol. The aldehyde can also be obtained by Friedel-Crafts acylation or formylation (POCI3/DMF) of the indole, etc. When F and/or D are ■ condensation of an acid or an acid halide with the appropriate aryl amine will give the desired compound. , - E The tetrazoles may be formed from the nitrile at various stages of the synthesis by treatment with hydrazoic acid formed in situ from sodium azide and an acid. The nitrile may also be converted to the acids, esters or amides by known methods. It is convenient to develop the synthesis of the final product by successively forming each desired substituent in turn. Thus in order to prepare a compound such as the following reaction sequence could be used: Certain compounds of this invention may have at least one asymmetric carbon atom such as those compounds having different geminal R groups. Further, certain compounds of this invention may exist in their ej≤. or trans configuration such as those compounds where D and/or F is CR CR. As a result, those compounds of this invention may be obtained either as racemic mixtures, diastereoisomeric mixtures or as individual enantiomers. The product may be synthesized as a mixture of the isomers and then the desired isomer separated by conventional techniques such as chromatography or fractional crystallization from which each diastereomer may be resolved. On the other hand, synthesis may be carried out by known stereospecific processes using the desired form of the intermediate which would result in obtaining the desired stereospecificity. Reference to the separation of cj≥ and trans isomers by chromatography may be found in W. K. Chan, ei al, J. Am. Chem. Soc. 9_6_, 3642, 1974. It is to be understood that the scope of this invention encompasses not only the various isomers which may exist but also the various mixture of isomers which may be formed. The resolution of the compounds of this invention and their starting materials may be carried out by known procedures. Incorporation by reference is hereby made to the four volume compendium O p tical Resolution Procedures for Chemical Compounds: Optical Resolution Information Center, Manhattan College, Riverdale, New York. Such procedures are useful in the practive of this invention. A further useful reference is Enantiomers. Racemates and Resolutions: Jean Jacques, Andre Collet and Samuel H. Wilen; John Wiley & Sons, Inc., New York, 1981. Basically, the resolution of the compounds is based on the differences in the physical properties of diastereomers. Conversion of the racemates into a mixture of diastereomers by attachment of an enantiomerically pure moiety results in forms that are separable by fractional crystallization, distillation or chromatography. The present compounds form salts with acids when a basic amino function is present and salts with bases when an acid function, i.e., carboxyl, is present. All such salts are useful in the isolation and/or purification of the new products. Of particular value are the pharmaceutically acceptable salts with both acids and bases. Suitable acids include, for example, hydrochloric, sulfuric, nitric, benzenesulfonic, toluenesulfonic, acetic, maleic, tartaric and the like which are pharmaceutically acceptable. Basic salts for pharmaceutical use are the Na, K, Ca and Mg salts. Various substituents on the present new compounds, e.g., as defined in R2 and R" can be present in the starting compounds, added to any one of the intermediates or added after formation of the final products by known methods of substitution or conversion reactions. If the substituents themselves are reactive, then the substituents can themselves be protected according to the techniques known in the art. A variety of protecting groups known in the art, may be employed. Examples of many of these possible groups may be found in "Protective Groups in Organic Synthesis" by T. W. Green, John Wiley and Sons, 1961. For example, nitro groups can be added by nitration and the nitro group converted to other groups, such as amino by reduction, and halo by diazotization of the amino group and replacement of the diazo group. Acyl groups can be added by Friedel-Crafts acylation. The acyl groups can then by transformed to the corresponding alkyl groups by various methods, including the Wolff-Kishner reduction and Clemmenson reduction. Amino groups can be alkylated to form mono- and di-alkylamino groups; and mercapto and hydroxy groups can be alkylated to form corresponding ethers. Primary alcohols can be oxidized by oxidizing agents known in the art to form carboxylic acids or aldehydes, and secondary alcohols can be oxidized to form ketones. Thus, substitution or alteration reactions can be employed to provide a variety of substituents throughout the molecule of the starting material, intermediates, or the final product. Compounds within the scope of the present invention have potent activity as leukotriene B4 antagonists and as such possess therapeutic value in the treatment of inflammatory conditions and hypersensitivity responses. LTB4 is implicated in diseases such as rheumatoid arthritis, gout, psoriasis and inflammatory bowel disease and therefore compounds which demonstrate LTB4 antagonist properties would be of valuable in the control of these states. The LTB4 guinea pig polymorphonuclear membrane binding assay can be used to determine compounds exhibiting LTB4 receptor binding properties. Compounds active in this assay can then be subjected to the guinea pig peritoneal PMN LTB4-induced aggregation assay. THE LTB4-induced aggregation assay determines the antagonistic activity of a compound. The guinea pig LTB4-induced wheal assay is used to determine in vivo activity. Assay for Inhibitors of (3HVLTB Binding to Membranes From Guinea Pig Polvmorphonuclear Leukocytes Preparation of test compounds Dissolve compounds to a concentration 100-fold higher than the highest desired concentration for testing. Serially dilute the compound so that all dilutions are 100-fold higher than the assay concentration desired. Compounds are typically dissolved in DMSO. If compounds are insoluble in DMSO, solutions are heated or sonicated to induce solubilization. Compounds may also be dissolved in ethanol. Final assay concentrations of DMSO and ethanol can be as high as 1.0% and 2.0% (v/v); these concentrations have no measurable effects on specific binding. Preparation of the membrane receptor fraction To obtain polymorphonuclear leukocytes (PMNs), 25-30 male Hartley guinea pigs (250-350g) are intraperitoneally injected with 6 mis of an 8% sodium casemate solution. 18 to 24 hours later, the guinea pigs are sacrificed by decapitation. The peritoneal cavity is lavaged with 15 mis of isolation buffer. The cells are collected and centrifuged at 200xg for 10 minutes. Contaminating red blood cells can be removed by hypotonic lysis. The cells are resuspended in isolation buffer and centrifuged as before. They are filtered through gauze and centrifuged again. The resulting pellet is suspended in 3 ml of sonication buffer, counted and brought to a concentration of 1 x 10** cells/ml. This suspension is lysed on ice with 5 bursts of 30 seconds separated by 1 minute intervals. The homogenate is centrifuged at 200xg for 10 minutes at 4°C. Aliquots of supernatant are transferred to high speed centrifuge tubes (1 tube per 3 guinea pigs). The tubes are centrifuged at 49,000xg for 15 minutes at 4°C. The pellets are resuspended by three 5 second bursts of sonication, separated by 20 second intervals. This suspension is centrifuged at 50,000xg for 20 minutes at 4°C. Pellets are stored at -70°C for up to 3 months. To use in the binding assay, the pellet is thawed at room temperature and suspended in 9 mis of assay buffer (sonication may be necessary). Binding assay Each assay tube (16 x 100 mm) contains the following: 345 μl Assay Buffer 5 μl Test compound or solvent 100 μl Protein preparation (0.2 mg) Incubations are done at 30°C for 40 minutes in a water bath. Reactions are started by the addition of ( 3 H)-LTB4 solution. Samples are collected via a Brandel M24 Harvester for binding assays. Tubes should be washed with a total of 19 ml cold wash buffer. The filters are transferred to 7 ml plastic scintillation vials to which 6.0 ml of appropriate scintillation fluid (e.g., Scintiverse®) is added. After being allowed to equilibrate for 12 hours, the radioactivity is counted with a liquid scintillation counter appropriately set for tritium. The required control assay tubes include the following: (a) Total Binding: No test compound is added; buffer is substituted. (b) Non-Specific Binding: Non-labeled ligand is added at a concentration of 1 μM. (c) Solvent Controls: If test compound is dissolved in a solvent, controls for both Total Binding and Non-Specific Binding containing solvent but no compounds are required. Calculations: Specific binding is defined as that amount of radioligand prevented from binding by 1000-fold excess non-labeled ligand, i.e., total binding minus non- specific binding. This operational definition is verified by Scatchard analysis of total binding. Inhibition of specific binding is defined as the decrease in specific binding caused by the test compound, SB Q - SBy x 100 SB C where SBc is the specific binding in the absence of test compound and SBj is the specific binding in the presence of test compound. The I50 values (concentrations required to inhibit specific binding by 50%) are determined by graphic analysis of the specific binding observed in the presence of various concentrations of test compound. The results of this test indicate that compounds of this invention exhibit valuable LTB4 receptor binding properties which are useful in the treatment of inflammatory conditions and hypersensitivity responses. LTB^-lnduced Wheal Formation in Guinea Pio LTB4 plays the role of a mediator in cellular induced inflammation. The induction of chemokinesis and chemotaxis of PMNs and macrophage by LTB4 have contributed to its association with the vascular aspects of acute inflammatory reactions. In this test intradermal injection of 0.1 ml of a 10 μg/ml solution of LTB4 to guinea pig back skin causes the formation of a wheal. This wheal is visualized by the prior intravenous injection with the indicator 1% Evan's Blue dye. Following a 2 hour incubation post-LTB4 challenge, the guinea pigs are euthanized via CO2 asphyxiation. Their dorsal skins are reflected and the diameters of the challenged sites are compared with those of the vehicle control injected sites. Preparation and handling of guinea pigs The guinea pigs must be quarantined 5 to 7 days prior to the study. The day before the test, the back and hind limbs are shaved taking care not to nick the skin. After shaving, the guinea pigs are fasted, but water is provided. On the day of the test, the guinea pigs are weighed and identified with an ink mark designating them with numbers 1 through 5 in each group. Groups are formed by random distribution. Preparation and route of administration of compounds The oral vehicles are Polyethylene Glycol (PEG 400) (2 ml/kg) and methocel (0.5% w/v) (10 ml/kg). Exposure to the ultrasound of a Branson sonicator assures uniformity of suspension or dissolution of the test compounds. Compounds for parenteral administration are dissolved in saline with the assistance of 0.1 N HCI and 0.1 N NaOH and then adjusting the pH to near neutrality. Although test compounds are usually administered orally, other routes of administration such as intravenous, intraperitoneal or subcutaneous may be used. Preparation of leukotriene B^ for intradermal injection LTB4 is obtained as a stock solution (50 μg/ml) in ethanol and is stored at -β0°C until required for use. The stock solution or an appropriate aliquot is transferred from the ampule into a 10 ml glass vial using a pasteur pipette. The stock solution is then evaporated to dryness under a slow, steady stream of argon gas. A solution of freshly prepared 0.25% Bovine Albumin in Phosphate- Buffered Saline is bubbled with argon gas until the saturation point is reached (approximately 5 minutes). This argon-saturated vehicle is then used to reconstitute the evaporated LTB4 stock residue to yield a final working concentration of 10 μg/ml. The rubber stoppered vial of LTB4 working solution is kept on wet ice during the study. Preparation of Evan's Blue dve solution Because Evan's Blue is an easily visible marker that binds to the plasma proteins, it has been selected to assist the investigator in the measurement of the wheals induced during the study. Evan's Blue Dye is dissolved as a 1% w/v solution in 0.9% w/v physiologic saline. The number of 1 ml plastic disposable syringes, fitted with 27 gauge, 1/2 inch needles and filled with the 1% dye solution, is determined by the number of animals expected to be included in the study. Conduct of an experiment Test compounds or their appropriate controls are administered orally with 16 gauge, 3 inch dosing cannulas. Immediately after dosing, the guinea pig is injected intravenously with 1 ml of 1% Evan's Blue Dye into a digital vein in the left or right shaved hind limb. This injection is facilitated best through the use of a 1 ml plastic syringe fitted with a 27 gauge, 1/2 inch needle. Immediately following Evan's Blue injection, the guinea pig is injected intracutaneously at each of 2 sites in the shaved dorsal midline with 0.1 ml of the prepared argon-saturated LTB4 solution (1 μg/0.1 ml). A third site is intracutaneously injected with the argon-saturated 0.25% bovine albumin in phosphate-buffered saline to serve as a vehicle control. 2 hours after challenge, the guinea pigs are euthanized by inhalation of carbon dioxide. Carbon dioxide is administered by inserting a rubber tube from the tank into a plastic bag containing the caged group of guinea pigs. Asphyxiation occurs in approximately 5 minutes. After death, the dorsal skins are reflected to enable the measurement of 2 perpendicular diameters of the resultant wheals. The area of each wheal is determined using the formula: Area = πr 2 . Calculations and statistics For each guinea pig, the mean of the wheal areas obtained for the 2 injections sites is established after correction is made for the effect of the wheal area induced by the 0.25% Bovine Albumin in Phosphate-Buffered Saline vehicle. Then, a mean area for each treatment group with its corresponding standard error is calculated. The following equation is used to calculate the percent inhibition of vehicle treated control wheal area by treatment with test compound: Mean Wheal Area (C on t r ol) - Mean Wheal Area (Treated) Mean Wheal Area (Control) In multiple dose experiments, the dose of a test compound that will cause 50% inhibition (ED50) can be calculated from the regression equation for the response as percent inhibition (y) and log dose (x) and estimating the (ED50) from: y(50) = bx + m where: y= 50% inhibition, x = dose of test compound, b = slope of dose response line and m = intercept of the dose response line. 95% confidence limits of ED50 are calculated from the regression equation by the method of Litchfield and Wilcoxon where: ED25 = y(25) = bx + m, ED75 = #(75) = bx + m and s = (ED 75 /ED 50 ) + (ED 50 /ED 25 ) 2 where S is the slope function used to compute the limit factor fEDso 2.77/VN as fEDso = S. 2.77 is an estimator, N is the square root of the number of animals used for all the doses and fEDso is the factor to determine the upper (RU) and lower (RL) limits of the ED50 as: RU = ED50 x fEDso and RL = ED50 ÷ fEDso. Statistical significance of any inhibition caused by treatment with a test compound can be calculated by applying Student's t (two-tailed) to the data. Validation and specificity studies The 1 μg/0.1 ml/site challenge dose of LTB4 was selected for the reproducibility, sensitivity and ease of measurement of the resultant wheal. Studies have indicated that size of wheals induced by LTB4 is directly related to the dose administered. 2 hours of incubation after intradermal challenge with LTB4 was selected as the routine timing for the study. Duration studies conducted evidenced the production of measurable, reproducible wheals at the 2 hour endpoint. In view of the results obtained when compounds of the present invention are subjected to this test, it can be demonstrated that valuable properties as LTB4 antagonists are indicated. A further test which may be used to determine the ability of compounds of this invention to exhibit LTB4 antagonist activities is as follows: Guinea Pig Polvmorohonuclear Leukocyte Aggregation Assay Isolation of guinea pig PMNs 6 ml of 6% Na-caseinate (in saline) is injected intraperitoneally into 2 male guinea pigs (250-300g) lightly anesthetized with CO2 or ether. The following day (1δ-24 hours post injection) the animals are sacrificed by decapitation or CO2 overdose according to the SOP for nonclinical laboratory study methods. A midline section of abdominal skin is removed and 13 ml Hanks buffer (containing 500 μl 10 mM EDTA/500 ml Hanks) plus 2 ml 7% Na-citrate is injected into the peritoneal cavity. The guinea pig is rocked back and forth 5 times. A small incision is made on the left side of the midline of the abdominal wall (avoid cutting obvious blood vessels). Use a fire-polished pasteur pipette to transfer the buffer plus cells from the abdominal cavity to 2 washed Nalgene (Oak Ridge) centrifuge tubes (half of buffer and cells in each tube). The tubes are then filled to 50 ml with additional citrate-Hanks buffer and centrifuged at 4000 rpm for 10 minutes. Each pellet is resuspended in 1 ml of citrate-Hanks and then diluted to 50 ml with the same buffer. The cells are incubated for 30 minutes at room temperature on a Hema-Tek aliquot mixer. The cells are filtered through 2 layers of gauze into 50 ml with plastic beakers to remove PMN aggregates and then transferred to fresh, washed, 50 ml Nalgene centrifuge tubes. The cells are centrifuged for 5 minutes, resuspended in 50 ml of fresh buffer, centrifuged again and then resuspended in 3 ml of citrate-free Hanks buffer. (Following any centrifugation the cells are always resuspended first in 1 ml of the desired fresh buffer.) An aliquot of the washed cells, diluted 50-fold, is counted using a microscope and a hemacytometer. The PMNs are counted as follows: 1. Dilute 50 μl of cells into 450 μl of Hank's buffer. 2. Dilute 50 μl of (1 ) with 150 μl of Hank's buffer plus 50 μl of Toluidine blue (50x total dilution). Add 10 μl of (2) to the hemacytometer and count cells in 16 large squares (volume counted = 1 μl). View the hemacytometer under 40x magnification. The unstained cells are PMNs. Calculation: Asssume 149 cells are counted. # of cells counted/ml x dilution factor x 2 ml Final volume of = buffer needed/ml desired final cell concentration 0 f ce || s cells/ml = 149/.0001 = 1 ,490,000 cells/ml 1 .49 x 10 6 x 50 x 1 = 7.45 x 10 — 8 = 2.4 A 8 O m .l/.ml. of. cel.l.s coun < t,ed __, 3 x 10 7 3 x 10' Thus, cells must be diluted 2.48-fold with Hanks buffer (2.48 x 3 = 7.44 ml; 7.44 - 3.0 = 4.44; add 4.44 ml buffer to the 3 ml of washed cells). This results in 7.44 ml of cells at a concentration of 3 x 10? cells per ml. Instrument adjustments Place cuvettes containing 1 x 10 7 cells/ml (166 μl PMNs plus 334 μl buffer) plus flea magnets in the aggregometer sample wells. Turn on the Chart Advance to 30 cm/hr. Turn the attenuation dials to mid range and decrease the recorder mV range settings to 50 mV full scale. Press the red "zero" button on the aggregometer and note exactly the position of the recorder pens. Turn the aggregometer left hand "PPP" dials for each cuvette position to the left or right so that the associated recorder pens move to the exact positions noted by pressing the red "zero" button. The electrical circuits are now "balanced". Except for small balance adjustments, do not make any further changes in pen positions by adjusting the H ppp" dials. Withdraw one of the cuvettes from the aggregometer and note the (positive) direction of recorder pen motion. Replace the cuvette. Using the recorder zero knob, move the recorder pen in the positive direction to the chart paper 95% line. The pens now should not move when the red "zero" button is pressed. The pen also should not move when the mV sensitivity range is changed to 20 or 10 mV full scale (leave at 10 mV). PMN aggregation should cause the pen to move in the "negative" direction across the chart paper. Make comparable adjustments for the second aggregometer channel but zero the recorder pen on the opposite side of the chart paper. Finally, pressing the zero button on either the recorder or the aggregometer should noj cause the pens to move more than a mm or two. This instrument configuration will result in maximal pen deflection following aggregation of cells. Aggregation studies To a cuvette containing 334 μl of buffer and a flea magnet, add 166 μl of PMNs, 10 μl of Ca==/Mg++ (70/et mM; 1.4/0.7 mM final) and 5 μl of 10 μM cytochalasin-β allow to warm up in the aggregometer (37°C) for 5 minutes and then add 1 μl of test compound in DMSO or DMSO carrier alone. Note compound effects, if any, for 2 minutes, then add 5 μl of the challenge agonist (LTB4, PAF, etc.) and observe the response for at least 2 minutes. The standard concentrations of agonists used in this assay are arachidonic acid, 6 μM; LTB4, 0.3 nM; PAF, 30 pM; and FMLP, 0.6 nM. Aggregation is quantitated by measuring, in millimeters, the average maximum deflection of the pen line at 1 minute or less after the addition of LTB4. The maximum response to a control challenge with arachidonic acid may develop somewhat more slowly than this. Each aggregometer-recorder channel should include its own series of control aggregations. All compounds should be tested at least twice at each concentration of interest. The inhibitory activity observed is expressed as the mean percent change (inhibition) observed relative to the controls determined in that channel. Controls must include appropriate solvent blanks. The results of the above test demonstrate that compounds within the scope of this invention inhibit the activity of LTB4. The compounds of the present invention can be administered to a mammalian host in a variety of forms adapted to the chosen route of administration, i.e., orally, or parenterally. Parenteral administration in this respect includes administration by the following routes: intravenous, intramuscular, subcutaneous, intraocular, intrasynovial, transepthelially including transdermal, ophthalmic, sublingual and buccal; topically including ophthalmic, dermal, ocular, rectal and nasal inhalation via insufflation and aerosol and rectal systemic. The active compound may be orally administered, for example, with an inert diluent or with an assimilable edible carrier, or it may be enclosed in hard or soft shell gelatin capsules, or it may be compressed into tablets, or it may be incorporated directly with the food of the diet. For oral therapeutic administration, the active compound may be incorporated with excipient and used in the form of ingestible tablets, buccal tablets, trochees, capsules, elixirs, suspensions, syrups, wafers, and the like. Such compositions and preparations should contain at least 0.1% of active compound. The percentage of the compositions and preparations may, of course, be varied and may conveniently be between about 2 to about 6% of the weight of the unit. The amount of active compound in such therapeutically useful compositions is such that a suitable dosage will be obtained. Preferred compositions or preparations according to the present invention are prepared so that an oral dosage unit form contains between about 50 and 300 mg of active compound. The tablets, trochees, pills, capsules and the like may also contain the following: A binder such as gum tragacanth, acacia, corn starch or gelatin; excipients such as dicalcium phosphate; a disintegrating agent such as corn starch, potato starch, alginic acid and the like; a lubricant such as magnesium stearate; and a sweetening agent such as sucrose, lactose or saccharin may be added or a flavoring agent such as peppermint, oil of wintergreen, or cherry flavoring. When the dosage unit form is a capsule, it may contain, in addition to materials of the above type, a liquid carrier. Various other materials may be present as coatings or to otherwise modify the physical form of the dosage unit. For instance, tablets, pills, or capsules may be coated with shellac, sugar or both. A syrup or elixir may contain the active compound, sucrose as a sweetening agent, methyl and propylparabens a preservatives, a dye and flavoring such as cherry or orange flavor. Of course, any material used in preparing any dosage unit form should be pharmaceutically pure and substantially non-toxic in the amounts employed. In addition, the active compound may be incorporated into sustained-release preparations and formulations. The active compound may also be administered parenterally or intraperitoneally. Solutions of the active compound as a free base or pharmacologically acceptable salt can be prepared in water suitably mixed with a surfactant such as hydroxy-propylcellulose. Dispersion can also be prepared in glycerol, liquid polyethylene glycols, and mixtures thereof and in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms. The pharmaceutical forms suitable for injectable use include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. In all cases the form must be sterile and must be fluid to the extent that easy syringability exists. It may be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), suitable mixtures thereof, and vegetable oils. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. The prevention of the action of microorganisms can be brought about by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars or sodium chloride. Prolonged absorption of the injectable compositions of agents delaying absorption, for example, aluminum monostearate and gelatin. Sterile injectable solutions are prepared by incorporating the active compound in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the various sterilized active ingredient into a sterile vehicle which contains the basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum drying and the freeze drying technique which yield a powder of the active ingredient plus any additional desired ingredient from previously sterile-filtered solution thereof. The therapeutic compounds of this invention may be administered to a mammal alone or in combination with pharmaceutically acceptable carriers, as noted above, the proportion of which is determined by the solubility and chemical nature of the compound, chosen route of administration and standard pharmaceutical practice. The physician will determine the dosage of the present therapeutic agents which will be most suitable for prophylaxis or treatment and it will vary with the form of administration and the particular compound chosen, and also, it will vary with the particular patient under treatment. He will generally wish to initiate treatment with small dosages by small increments until the optimum effect under the circumstances is reached. The therapeutic dosage will generally be from 0.1 to 100 M/day or from about 0.1 mg to about 50 mg/kg of body weight per day and higher although it may be administered in several different dosage units. Higher dosages are required for oral administration. The compounds of the present invention may be prepared by the following representative examples: Example 1 N-methyl-N-phenethyl-2-bromoacetamide To a solution of 27.07g (171.95 mmol) of bromoacetyl chloride in 100 ml of methylene chloride, cooled to -25°C by means of an external cooling bath, is added dropwise a solution of 46.5g (343.9 mmol) of N-methyl-N-phenethyl amine in 50 ml of methylene chloride over a period of 1 1/2 hours. The reaction mixture is stirred at -25°C for additional 15 minutes and then allowed to equilibrate to room temperature. The reaction mixture is then partitioned between methylene chloride and water. The organic layer is washed with 1 N aqueous HCI solution and water, dried over magnesium sulfate and concentrated in vacuo to give N-methyl-N-phenethyl-2-bromoacetamide which is used directly in the next step. Example 2 5-[2-(N-methyl-N-phenethvhamino-2-oxo1ethoxyindole A mixture of 1g (7.29 mmol) of 5-hydroxyindole, 2.42g (9.4 mmol) of N-methyl-N-phenethyl-2-bromoacetamide and 1.06g of finely ground anhydrous potassium carbonate in 20 ml of 2-butanone is heated to a gentle reflux for 18 hours. After cooling to room temperature, the solid substance is filtered off and the filtrate concentrated in vacuo to give 3g of the crude product. Purification by dry column chromatography over silica gel eluting with a solvent system of ethyl acetate/hexane (1 :1 , v/v) gives 5-[2-(N-methyl-N-phenethyl)- amino-2-oxo]ethoxyindole. NMR confirms this structure. Example 3 5-benzyloxyindole 5-(4-methylbenzyloxy)indole When N-methyl-N-phenethyl-2-bromoacetate is replaced in the procedure of Example 2 with α-bromotoluene or α-bromo-p-xylene then the products prepared are 5-benzyloxyindole or 5-(4-methylbenzyloxy)indole. NMR confirms these structures. Example 4 6-benzyloxyindole 6-(4-methylbenzyloxy ndole When 5-hydroxyindole is replaced in the procedure of Example 3 with 6-hydroxyindole then the products prepared are 6-benzyloxyindole and 6-(4- methylbenzyloxy)indole. NMR confirms these structures. Example 5 6-f2-(N-methyl-N-phenethvhamino-2-oxo|ethoxyindole When 5-hydroxyindole is replaced in the procedure of Example 2 with 6-hydroxyindole then the product prepared is 6-[2-(N-methyl-N-phenethyl)- amino-2-oxo]ethoxyindole. Example 6 5-f2-(N-methyl-N-phenethyhamino-2-oxo1ethoxyindole-3-carboxaldehvde To 2.4 ml of N,N-dimethylformamide, stirred under nitrogen in a cooling bath of 10-20°C is added dropwise 0.76 ml of phosphorous oxychloride. The mixture is stirred for an additional 10 minutes and a solution of 2.2g of N-methyl-N-phenethyl-2-(5-indolyloxy)acetamide in 6.5 ml of N,N-dimethyl- formamide is added dropwise. The reaction mixture is stirred at room temperature for 50 minutes and poured into 45 ml of an ice-water mixture with stirring. The mixture is adjusted to pH 7 with aqueous sodium hydroxide solution, heated in a water bath of 95°C for three minutes and allowed to cool to room temperature. Ethyl acetate is added and the layers separated. The organic layer is washed with a small amount of 1 N aqueous HCI solution and several times with brine, dried over magnesium sulfate and concentrated jn. vacuo. The residue is purified by dry column chromatography over silica gel eluting with a solvent system of 10% ethyl acetate in hexane to afford 5-[2-(N- methyl-N-phenethyl)amino-2-oxo]ethoxyindole-3-carboxaldehyde as a beige solid substance. NMR confirms this structure. Example 7 5-benzyloxyindole-3-carboxaldehvde 5-f4-methvlbenzvloxv indole-3-carboxaldehvde When N-methyl-N-phenethyl-2-(5-indolyloxy)acetamide is replaced in the procedure of Example 6 with 5-benzyl-oxyindole and 5-(4-methyl- benzyloxy)indole then the products obtained are 5-benzyloxyindole-3- carboxaldehyde and 5-(4-methylbenzyloxy)indr . -3-carboxaldehyde. NMR confirms these structures. Example 8 6-benzyloxyindole-3-carboxaldehvde 6-(4-methylbenzyloxy t )indoie-3-carboxaldehvde When N-methyl-N-phenethyl-2-(5-indolyloxy)acetamide is replaced in the procedure of Example 6 with 6-benzyl-oxyindole and 6-(4-methyl benzyloxy)indole then the products obtained are 6-benzyloxyindole-3- carboxaldehyde and 6-(4-methylbenzyloxy)indole-3-carboxaldehyde. Example 9 6-[2-(N-methyl-N-phenethvhamino- 2-oxo1ethoxyindole-3-carboxaldehvde When N-methyl-N-phenethyl-2-(5-indolyloxy)acetamide is replaced in the procedure of Example 6 with N-methyl-N-phenethyl-2-(6-indolyloxy)- acetamide then the product prepared is 6-[2-(N-methyl-N-phenethyl)amino-2- oxo]ethoxyindole-3-carboxaldehyde. Example 10 N-methyl-N-Phenethyl-2-f(5-benzyloxy-3-formv indol-1-yl]acetamide To a suspension of sodium hydride (615 mg, 80% dispersion in mineral oil, 20.5 mmol) in 90 ml of tetrahydrofuran, cooled to 0°C by means of an external ice bath, is added in portions 4.9g (19.52 mmol) of 5-benzyl- oxyindole-3-carboxaldehyde. The reaction mixture is stirred in the ice bath for an additional 10 minutes and 5g (19.52 mmol) of N-methyl-N-phenethyl-2- bromoacetamide added. The resulting mixture is stirred at room temperature for 1 β hours. The reaction mixture is filtered through Cellite® to remove the precipitate and the filtrate concentrated in vacuo to give an oily substance. Purification of this crude product by chromatography over silica gel eluting with a solvent system of methylene chloride/ethyl acetate (2:1 , v/v) gives N-methyl-N- phenethyl-2-[(5-benzyloxy-3-formyl)indol-1-yl]acetamide as a white powder (m.p. 78-80°C). Example 11 N-methyl-N- p henethyl-2-f ( 6-benzyloxy-3-formyl ndol-1-vπacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 6-benzyloxyindole-3-carboxaldehyde then the compound prepared is N-methyl-N-phenethyl-2-[(6-benzyloxy-3-formyl)indol-1* yljacetamide. NMR confirms structure. Example 12 N-methyl-N-phenethyl-2-|Y5-(2-methylphenethyl- amino-2-oxo thoxy-3-formvπindol-1 -vπacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 5-[2-(N-methyl-N-phenethyl)amino-2-oxo]- ethoxyindole-3-carboxaldehyde then the product prepared is N-methyl-N- phenethyl-2-[(5-(2-methylphenethylamino-2-oxo)ethoxy-3-formyl)indol-1 -yl]- acetamide. Example 13 N-methyl-N-phenethyl-2-f(6-(2-methylphenethylamino- 2-oxo ethoxy-3-formvπindol-1-yl1acetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 6-[2-(N-methyl-N-phenethyl)amino-2-oxo]- ethoxyindole-3-carboxaldehyde then the product prepared is N-methyl-N- phenethyl-2-[(6-(2-methylphenethylamino-2-oxo)ethoxy-3-formyl)indol-1-yl]- acetamide. Example 14 N-methyl-N-(4-methoxy)phenethyl-2-bromoacetamide A mixture of 0.55g of N-methyl-N-(4-methoxy)-phenethylamine, 0.51 g of bromoacetic acid and 1.56g of 1-cyclohexyl-3-(2-morpholinoethyl)- carbodiimide metho-p-toluenesulfonate in 10 ml of methylene chloride is stirred at room temperature for 4δ hours. The reaction mixture is filtered and the filtrate is concentrated in, vacuo to give an oily residue. Purification of the residue by dry column chromatography over silica gel eluting with a solvent system of hexane/ethyl acetate (2:1 , v/v) gives 0.δδ4g of N-methyl-N-(4- methoxy)phenethyl-2-bromoacetamide as a beige oil. NMR confirms this structure. Example 15 N-(4-methoxy phenethyl-N-methyl-2- ff5-benzyloxy-3-formvπindol-1-yl|acetamide When N-methyl-N-phenethyl-2-bromoacetamide in the procedure of Example 10 is replaced by N-methyl-N-(4-methoxy)phenethyl-2-bromoacetate then the product prepared is N-(4-methoxy)phenethyl-N-methyl-2-[(5- benzyloxy-3-formyl)indol-1-yl]acetamide. NMR confirms this structure. Example 16 2-methyl-4-benzyloxyindole 7-benzyloxyindole When 5-hydroxyindole in the procedure of Example 3 is replaced with 2- methyl-4-hydroxyindole or 7-hydroxyindole then the products prepared are 2- methyl-4-benzyloxyindole and 7-benzyloxyindole. Example 17 2-methyl-4-benzyloxyindole-3-carboxaldehvde 7-benzyloxyindole-3-carboxaldehvde When 5-benzyloxyindole in the procedure of Example 7 is replaced by 2-methyl-4-benzyloxyindole and 7-benzyloxy-indole then the products prepared are 2-methyl-4-benzyl-oxyindole-3-carboxaldehyde and 7- benzyloxyindole-3-carboxaldehyde. Example 16 N-methyl-N-phenethyl-2-f ( 4-benzyloxy-3-formvhindol-1-vnacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 4-benzyloxyindole-3-carboxaldehyde then the product prepared is N-methyl-N-phenethyl-2-[(4-benzyloxy-3-formyl)indol-1- yljacetamide. Example 19 N-methyl-N-phenethyl-2-r ( 7-benzyloxy-3-formylVmdol-1-vnacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 7-benzyloxyindole-3-carboxaldehyde then the product prepared is N-methyl-N-phenethyl-2-[(7-benzyloxy-3-formyl)indol-1- yljacetamide. NMR confirms this structure. Example 20 N-methyl-N-phenethyl-2-ff5-(4-methylbenzyloxy)-3-formvhindol-1-vnacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 5-(4-methyl-benzyloxy)indole-3-carboxaldehyde then the product prepared is N-methyl-N-phenethyl-2-[(5-(4-methylbenzyloxy)- 3-formyl)indol-1 -yl]acetamide. NMR confirms this structure. Example 21 1 -benzyl-5-[2-(N-methyl-N-phenethvhamino- 2-oxo]ethoxyindole-3-carboxaldehvde When N-methyl-N-phenethyl-2-bromoacetamide in the procedure of Example 12 is replaced by benzyl bromide then the compound prepared is 1-benzyl-5-[2-(N-methyl-N-phenethyl)amino-2-oxo]ethoxyindole-3- carboxaldehyde. NMR confirms this structure. Example 22 N-methyl-N-phenethyl-2-[5-benzyloxy-3- (2-carbethoxvvinvhindol-1 -vllacetamide To a suspension of NaH (1.6δg, 60% dispersion in mineral oil, 56 mmol) in 150 ml of tetrahydrofuran, stirred in an ice bath under an atmosphere of nitrogen, is added dropwise a solution of 11.25 ml (9δ% reagent, 54.45 mmol) of triethyi phosphonoacetate in 30 ml of THF. The resulting mixture is stirred in the ice bath for an additional 20 minutes and a solution of N-methyl-N- phenethyl-2-[(5-benzyloxy-3-formyl)indol-1-yl]acetamide (15.5g, 36.3 mmol) in 60 ml of THF is added quickly. The ice bath is then removed and the mixture stirred for 1δ hours at room temperature. The reaction is quenched with water and ethyl acetate is added. The layers are separated and the organic layer is washed with brine, dried over MgSθ4 and concentrated in vacuo to give a beige oil. The crude product is purified by dry column chromatography over silica gel eluting with a solvent system of 10% ethyl acetate in methylene chloride to give N-methyl-N- phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol-1 -yl]acetamide. Trituration of this substance in diethyl ether gives pure compound as a white powder (m.p. 136-139°C (dec)). 33 Example 23 N-methyl-N-phenethyl-2-| " 5-benzyloxy-3- f2-carboxwinvπindol-1 -yl1acetamide To a suspension of 14.δ5g (29.9 mmol) of N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-carbethoxyvinyl)indol-1-yl]acetamide in 750 ml of ethanol is added a solution of 2.52g of potassium hydroxide in 40 ml of water. The resulting suspension is stirred in a heating bath of 50°C for 20 hours and another batch of KOH solution (1.75g of KOH in 40 ml of water) is added. The mixture is stirred at 50°C for seven days after which time a homogeneous solution is obtained. After cooling to room temperature, ethanol is removed in vacuo. The residue is mixed with water and the unreacted ester extracted into ethyl acetate. The pH of the aqueous layer is adjusted to about 7 with 1 N aqueous HCl solution. The white precipitate obtained is collected by filtration, washed with water and dried in vacuo to yield N-methyl-N-phenethyl-2-[5-benzyloxy-3- (2-carboxyvinyl)indol-1-yl]acetamide as a white powder (m.p. 190-192°C (dec)). Example 24 N-methyl-N-phenethyl-2-f5-benzyloxy-3-(2-(1- pyrrolidinecarbonvπvinvπindol-1 -vnacetamide To a mixture of 0.63g (1.34 mmol) of N-methyl-N-phenethyl-2-(5- benzyloxy-3-(2-carboxyvinyl)indol-1-yl]-acetamide in 15 ml of methylene chloride, cooled to 0°C with an external ice bath, is added dropwise 0.26 ml (3.02 mmol) of oxalyl chloride, followed immediately with 3 drops of N,N- dimethylformamide. The mixture is stirred in an ice bath for 30 minutes and then for 1 hour with the cooling bath removed. The reaction mixture is then concentrated in vacuo. The residue obtained is dissolved in 10 ml of methylene chloride and this solution is added dropwise to a mixture of 0.11 ml (1.34 mmol) of pyrrolidine, 0.24 ml of pyridine and 15 ml of methylene chloride with stirring at 0°C (ice bath). The resulting reaction mixture is stirred at room temperature for several hours and quenched with saturated aqueous NH4CI solution. Ethyl acetate and water are added and the layers separated. The organic layer is washed with 1 N aqueous HCl solution and water, dried over magnesium sulfate and concentrated in vacuo. The residue is triturated in hot ethyl acetate to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-(1- pyrrolidinecarbonyl)-vinyl)indol-1 -yljacetamide (m.p. 165-1 δ7°C). Example 25 N-methyl-N-phenethyl-2-[5-benzyloxy-3- f2-carbethoxyethvhindol-1 -vnacetamide A mixture of 0.93g of N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2- carbethoxyvinyl)indol-1 -yljacetamide, 0.5g of 10% palladium on activated carbon and 150 ml of ethanol is shaken under 40 psi of hydrogen on a Parr Apparatus for 40 minutes. The mixture is filtered to remove the catalysts and the filtrate is concentrated in vacuo. The residue is purified by dry column chromatography over silica gel eluting with a solvent system of ethyl acetate/hexane (2:1 , v/v) to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2- carbethoxyethyl)indol-1 -yljacetamide as white powder (m.p. 81-83°C). Example 26 N-methyl-N-phenethyl-2-r5-benzyloxy- 3-(2-carboxvethvhindol-1 -vllacetamide To a suspension of 0.7g (1.4 mmol) of N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-carbethoxyethyl)indol-1 -yljacetamide in 20 ml of ethanol is added a solution of 0.2g of potassium hydroxide in 3 ml of water. The mixture is stirred at room temperature for 16 hours and concentrated in vacuo. The residue is dissolved in water and the resulting solution adjusted to pH 4 with 1 N aqueous HCl solution. The precipitate which forms is extracted into ethyl acetate. The organic solution is washed with brine, dried over magnesium sulfate and concentrated in vacuo to give N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-carboxyethyl)indol-1 -yljacetamide as a beige powder (m.p. 122-125°C). Example 27 N-(4-methoxyphenethvh-N-methyl-2-[Y5-benzyloxy- 3-(2-carbethoxwinvπindol-1-yl1acetamide When N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)-indol-1 - yljacetamide in the procedure of Example 22 is replaced with N-(4- methoxy)phenethyl-N-methyl-2-[(5-benzyloxy-3-formyl)indol-1 -yljacetamide then the product prepared is N-(4-methoxyphenethyl)-N-methyl-2-[(5- benzyloxy-3-(2-carbethoxyviny)indol-1 -yljacetamide. NMR confirms this structure. Example 26 N-methyl-N-phenethyl-2-r6-benzyloxy-3- (2-carbethoxwinv0indol-1 -yljacetamide When N-methyl-N-phenethyl-2-[(5-benzyioxy-3-formyl)-indol-1 - yljacetamide in the procedure of Example 22 is replaced with N-methyl-N- phenethyl-2-[(6-benzyloxy-3-formyl)indol-1 -yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[6-benzyloxy-3-(2-carbethoxyvinyl)-indol- 1 -yljacetamide. NMR confirms this structure. Example 29 N-methyl-N-phenethyl-2-f4-benzyloxy-3- (2-carbethoxwinvnindol-1-yl]acetamide When N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)-indol-1 - yljacetamide in the procedure of Example 22 is replaced with N-methyl-N- phenethyl-2-[(4-benzyIoxy-3-formyl)indol-1 -yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-carbethoxyvinyl)-indol- 1 -yljacetamide. (m.p. 110-120°C) Example 30 N-methyl-N-phenethyl-2-r7-benzyloxy-3- f2-carbethoxwinvnindol-1-vllacetamide When N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)indol-1 -ylj¬ acetamide in the procedure of Example 22 is replaced with N-methyl-N- phenethyl-2-[(7-benzyloxy-3-formyl)indol-1 -yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[7-benzyloxy-3-(2-carbethoxyvinyl)indol- 1 -yljacetamide. NMR confirms this structure. Example 31 N-methyl-N-phenethyl-2-r3-(2-carbethoxyvinylV5-(2-(N- methyl-N-phenethvhamino-2-oxotethoxyindol-1 -vπacetamide When N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)indol-1-ylj- acetamide in the procedure of Example 22 is replaced with N-methyl-N- phenethyl-2-[(5-(2-methylphenethylamino-2-oxo)ethoxy-3-formyl)indol-1 - yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[3-(2- carbethoxyvinyl)-5-(2-(N-methyl-N-phenethyl)amino-2-oxo)ethoxyindol-1 - yljacetamide. NMR confirms this structure. Example 32 N-methyl-N-phenethyl-2-f3- ( 2-carbethoxyvinvh- 5-(4-methylbenzyloxy)indol-1 -yljacetamide When N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)indol-1 -ylj¬ acetamide in the procedure of Example 22 is replaced with N-methyl-N- phenethyl-2-[(5-(4-methylbenzyloxy)-3-formyl)indol-1 -yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[3-(2-carbethoxyvinyl)-5-(4- methylbenzyloxy)indol-1 -yljacetamide. NMR confirms this structure. Example 33 1-benzvl-3-(2-carbethoxvvinvn-5-r2-(N- methyl-N-phenethvOamino-2-oxolethoxyindole When N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)indol-1 -ylj¬ acetamide in the procedure of Example 22 is replaced with 1-benzyl-5-[2-(N- methyl-N-phenethyl)amino-2-oxo]ethoxyindole-3-carboxaldehyde then the product prepared is 1 -benzyl-3-(2-carbethoxyvinyl)-5-[2-(N-methyl-N- phenethyl)amino-2-oxo]ethoxyindole. NMR confirms this structure. Example 34 When triethylphosphonoacetate in the procedure of Example 22 is replaced with the phosphonates of Table I below and N-methyl-N-phenethyl-2- [(5-benzyloxy-3-formyl)indol-1 -yljacetamide is replaced by the various aldehydes and ketones of this invention then the corresponding product is prepared. A representative list of compounds so prepared may be found in Examples 35-41 of Table II below. TABLE I trimethylphosphonoacetate triethylphosphonoacetate tripropylposphonoacetate tributylphosphonoacetate tri-tert-butylphosphonoacetate triethylphosphono-2-propionate triethylphosphono-3-butanoate triethylphosphono-2-buten-2-oate triethylphosphono-4-buten-2-oate TABLE Example 35 N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carb-t- butoxyvinyl πndol-1 -yllacetamide (Solvent system ethylacetate/hexane; m.p. 135°C (dec.).) Example 36 N-methyl-N-phenethyl-2-[5-benzyloxy-3-f2- carbmethoxyvinyl ndol-1 -yljacetamide NMR confirms this structure, (m.p. 155-156°C) Example 37 N-methyl-N-phenethyl-2-[2-methyl-4-benzyloxy- 3-(2-carbethoxy-2-methylvinylVmdol-1 -yljacetamide Example 36 N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2- carbethoxy-2-ethylvinyl.indol-1 -yljacetamide (m.p. 130-131 °C (dec.)) Example 39 N-methyl-N-Phenethyl-2-f1-benzyloxy-3-(2- carbethoxy-2-methylvinylVmdol-5-yljacetamide Example 40 N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2- carbethoxy-2-ethylvinvπindol-1 -yllacetamide Example 41 N-methyl-N-phenethyl-2-f5-benzyloxy-3-(4- carbethoxy-1.3-butadienylVmdol-1 -yllacetamide NMR confirms this structure. Example 42 N-(4-methoxyphenethvh-N-methyl-2-r(5-benzyloxy- 3-(2-carboxyvinvhindol-1 -yllacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxy- vinyl)indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-(4-methoxyphenethyl)-N-methyl-2-[(5-benzyloxy-3-(2-carbethoxyvinyl)indol- 1 -yljacetamide then the product prepared is N-(4-methoxyphenethyl)-N-methyl- 2-[(5-benzyloxy-3-(2-carboxyvinyl)indol-1 -yljacetamide. (m.p. 161 -162°C (dec.)) Example 43 N-methyl-N-phenethyl-2-[6-benzyloxy-3- (2-carboxyvinvπindol-1 -yljacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxy- vinyl)indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl-N-phenethyl-2-[6-benzyloxy-3-(2-carbethoxyvinyl)indol-1 -ylj¬ acetamide then the product prepared is N-methyl-N-phenethyl-2-[6-benzyloxy- 3-(2-carboxyvinyl)indol-1 -yljacetamide. (m.p. 201-202°C (dec.)) Example 44 N-methyl-N-phenethyl-2-f4-benzyloxy-3- (2-carboxyvinv0indol-1 -yljacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[4-benzyloxy-3-(2-carbethoxyvinyl)indol-1 -yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-carboxyvinyl)- indol-1 -yljacetamide. (m.p. 173-175°C (dec.)) Example 45 N-methyl-N-phenethyl-2-[7-benzyloxy-3- (2-carboxyvinvπindol-1 -yljacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[7-benzyloxy-3-(2-carbethoxyvinyl)indol-1 -yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[7-benzyloxy-3-(2-carboxyvinyl)- indol-1 -yljacetamide. (m.p. 192-193°C (dec.)) Example 46 N-methyl-N-phenethyl-2-r3-(2-carboxyvinvπ- 5-f2-fN-methyl-N-phenethvπamino-2- oxotethoxyindol-1 -yljacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[3-(2-carbethoxyvinyl)-5-(2-(N-methyl-N-phenethyl)amino-2- oxo)ethoxyindol-1 -yljacetamide then the product prepared is N-methyl-N- phenethyl-2-[3-(2-carboxyvinyl)-5-(2-(N-methyl-N-phenethyl)amino-2-oxo)- ethoxyindol-1 -yljacetamide. (m.p. 94-96°C (dec.)) Example 47 N-methyl-N-phenethyl-2-r3-(2-carboxyvinvπ- 5-(4-methylbenzyloxy)indol-1 -yljacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[3-(2-carbethoxyvinyl)-5-(4-methylbenzyloxy)indol-1 -ylj¬ acetamide then the product prepared is N-methyl-N-phenethyl-2-[3-(2- carboxyvinyl)-5-(4-methylbenzyloxy)indol-1 -yljacetamide. (m.p. 164-166°C) Example 46 N-methyl-N-phenethyl-2-r5-benzyloxy-3- (2-carboxy-2-methylvinvhindol-1 -yljacetamide N-methyl-N-phenethyl-2- 5-benzyloxy-3- (2-(ZVcarboxv-2-methvlvinvnindol-1-vnacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-1 -ylj- acetamide then the product prepared is N-methyl-N-phenethyl-2-[5-benzyloxy- 3-(2-carboxy-2-methylvinyl)-5-(4-methoxybenzyloxy)indol-1 -yljacetamide. (m.p. 220-231 °C (dec.)) When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol- 1 -yljacetamide in the procedure of Example 23 is replced with N-methyl-N- phenethyl-2-[5-benzyloxy-3-(2-(Z)-carbethoxyvinyl)indol-1 -yljacetamide, then the product prepared is N-metyl-N-phenethyl-2-[5-benzyloxy-3-(Z)-2-carboxy- 2-methylvinyl)indol-1 -yljacetamide as a white powder, (m.p. 155-160°C) Example 49 N-methyl-N-phenethyl-2-f5-benzyloxy-3- 4-carboxy- 1.3-butadienvhindol-1 -vllacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[1 -benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-5-ylj- acetamide then the product prepared is N-methyl-N-phenethyl-2-[5-benzyloxy- 3-(2-carboxy-1 ,3-butadienyl)indol-1 -yljacetamide. (solvent system (acetone/ether) m.p. 1δ9-190°C) Example 50 1 -benzyl-3-(2-carboxyvinylV5-f2-(N- methyl-N-phenethvhamino-2-oxojethoxyindole When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with 1-benzyl- 3-(2-carbethoxyvinyl)-5-[2-(N-methyl-N-phenethyl)amino-2-oxo]ethoxyindole then the product prepared is 1 -benzyl-3-(2-carboxyvinyl)-5-[2-(N-methyl-N- phenethyl)amino-2-oxoJethoxyindole. (m.p. 96-99°C) Example 51 N-methyl-N-phenethyl-2-[2-methyl-4-benzyloxy- 3-(2-carboxy-2-methylvinv0indol-1 -yllacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[2-methyl-4-benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-1 - yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[2-methyl-4- benzyloxy-3-(2-carboxy-2-methylvinyl)indol-1 -yljacetamide. Example 52 N-methyl-N-phenethyl-2-[5-benzyloxy-3- (2-carboxy-2-ethylvinvπindol-1 -yljacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxy-2-ethylvinyl)indol-1 -yljacetamide then the product prepared is N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2- carboxy-2-ethylvinyl)indol-1 -yljacetamide. (m.p. 205-207°C) Example 53 When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol- 1 -yljacetamide in the procedure of Example 25 is replaced by the unsaturated esters of Examples 27-33 and 35-41 then the products prepared are shown in Table III below. TABLE 111 N-(4-methoxyphenethyl)-N-methyl-2-[(5-benzyloxy-3-(2-carbethoxyethyl)indol- 1 -yljacetamide N-methyl-N-phenethyl-2-[6-benzyloxy-3-(2-carbethoxyethyl)indol-1-ylJ- acetamide N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-carbethoxyethyl)indol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[7-benzyloxy-3-(2-carbethoxyethyl)indol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[3-(2-carbethoxyethyl)-5-(2-(N-methyl-N-phenethyl)- amino-2-oxo)ethoxyindol-1 -yljacetamide N-methyl-N-phenethyl-2-[3-(2-carbethoxyethyl)-5-(4-methylbenzyloxy)indol-1- yljacetamide 1-benzyl-3-(2-carbethoxyethyl)-5-[2-(N-methyl-N-phenethyl)amino-2-oxoJ- ethoxyindole N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carb-t-butoxyethyl)indol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbmethoxyethyl)indol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[2-methyl-4-benzyloxy-3-(2-carbethoxypropyl)indol-1 - yljacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxybutyl)indol-1-ylJ- acetamide N-methyl-N-phenethyl-2-[1-benzyl-3-(2-carbethoxypropyl)indol-5-ylJacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxypropyl)indol-1 -ylj- acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-carbethoxybutyl)indol-1 -ylj¬ acetamide Example 54 When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyethyl)indol- 1 -yljacetamide in the procedure of Example 26 is replaced by the compound of Table III then the products prepared are shown in Table IV below. TABLE IV N-(4-methoxyphenethyl)-N-methyl-2-[(5-benzyloxy-3-(2-carboxyethyl)indol-1- yljacetamide N-methyl-N-phenethyl-2-[6-benzyloxy-3-(2-carboxyethyl)indol-1 -yljacetamide N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-carboxyethyl)indol-1 -yljacetamide N-methyl-N-phenethyl-2-[7-benzyloxy-3-(2-carboxyethyl)indol-1 -yljacetamide N-methyl-N-phenethyl-2-[3-(2-carboxyethyl)-5-(2-(N-methyl-N-phenethyl)- amino-2-oxo)ethoxyiπdol-1 -yljacetamide N-methyl-N-phenethyl-2-[3-(2-carboxyethyl)-5-(4-methylbenzyloxy)indol-1 -ylj¬ acetamide 1-benzyl-3-(2-carboxyethyl)-5-[2-(N-methyl-N-phenethyl)amino-2-oxoj- ethoxyindole N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxyethyl)indol-1 -yljacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxyethyl)indol-1 -yljacetamide N-methyl-N-phenethyl-2-[2-methyl-4-benzyloxy-3-(2-carboxypropyl)indol-1-ylj- acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxybutyl)indol-1 -yljacetamide N-methyl-N-phenethyl-2-[1-benzyl-3-(2-carboxypropyl)indol-5-yl]acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxypropyl)indol-1 -yljacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-carboxybutyl)indol-1 -yljacetamide Example 55 N-methyl-N-phenethyl-2-[5-benzyloxy-3-2-cvanovinvhindol-1 -yllacetamide To a suspension of 2g (8.30 mmoles) of acetonitriletriphenyl- phosphonium bromide (prepared from 1.24g bromo-acetonitrile and 2.98g triphenylphosphine refluxed in toluene for 1 hour) in 100 ml of dimethylformamide is added 0.27g (9.13 mmoles) of an 60% sodium hydride in oil dispersion. After stirring at 0°C for 1 hour, 3.54g (δ.30 mmoles) of N-methyl- N-phenethyl-2-[(5-benzyloxy-3-formyl)indol-1 -yljacetamide in 20 ml of dimethylformamide is added and stirred for 2 hours. The mixture is poured into ice water, extracted with ethyl acetate which is dried and concentrated in vacuo. Purification by flash column chromatography through silica gel gives N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-cyanovinyl)indol-1 -yljacetamide. Example 56 N-methyl-N-phenethyl-2-[5-benzyloxy-3- (2-tetrazol-5-yl inylindol-1 -yljacetamide A suspension of 0.94g (2.1 mmoles) of N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-cyanovinyl)indol-1 -yljacetamide, 0.56g (10.45 mmoles) of ammonium chloride and 0.6δg (10.45 mmoles) of sodium azide in 20 ml of dimethyl-formamide is heated at 100°C for 1δ hours. The mixture is poured into ice water. Addition of ethyl acetate gives a precipitate which is collected and triturated in acetone to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2- tetrazol-5-yl)vinylindol-1 -yljacetamide. (m.p. 203-205°C) Example 57 N-methyl-N-phenethyl-2-[5-benzyloxy-3- (2-tetrazol-5-vhethvlindol-1-vnacetamide To a solution 0.2g (0.42 mmoles) of N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-tetrazol-5-ylvinyl)indol-1 -yljacetamide in 30 ml of ethanol is added O.Oδg of 10% palladium on carbon and the mixture is shaken under 30 psi of hydrogen for 4 hours. The mixture is filtered and the filtrate concentrated in vacuo. The residue is crystallized from methylene chloride to give N-methyl- N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-yl)ethylindol-1 -yljacetamide. Example 58 When bromoacetonitrile in the procedure of Example 55 is replaced with the reagents of Table V below then the corresponding products are prepared which are further converted to the corresponding tetrazoles by Examples 56 and 57. TABLE V bromoacetonitrile 3-bromopropanenitrile 2-bromopropanenitrile 2-bromobutanenitrile 3-bromobutanenitrile 2-methyl-3-bromopropanenitrile 4-bromo-2-butenenitrile 4-bromo-2-pentenenitrile Example 59 When N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)indol-1 -ylj¬ acetamide is replaced in Example 55 and 5δ with the aldehydes and ketones of this invention the corresponding tetrazoles are prepared. A representative list of products so prepared is shown in Table VI. TABLE VI N-(4-methoxyphenethyl)-N-methyl-2-[(5-benzyloxy-3-(2-tetrazol-5-yl)vinylindol- 1 -yljacetamide N-methyl-N-phenethyl-2-[6-benzyloxy-3-(2-tetrazol-5-yl)vinylindol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-tetrazol-5-yl)vinylindol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[7-benzyloxy-3-(2-tetrazol-5-yl)vinyIindol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[3-(2-tetrazol-5-yl)vinyl-5-(2-(N-methyl-N-phenethyl)- amino-2-oxo)ethoxyindol-1 -yljacetamide N-methyl-N-phenethyl-2-[3-(2-tetrazol-5-yl)vinyl-5-(4-methylbenzyloxy)indol-1- yljacetamide 1-benzyl-3-(2-tetrazol-5-yl)vinyl-5-[2-(N-methyl-N-phenethyl)amino-2-oxoJ- ethoxyindole N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-yl)vinylindol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-tetrazol-5-yl-2-methylvinyl)indol-1 - yljacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-y.-2-ethylvinyl)indol-1- yljacetamide N-methyl-N-phenethyl-2-[1-benzyl-3-(2-tetrazol-5-yl-2-methylvinyl)indol-5-ylj- acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-yl-2-methylvinyl)indol-1 - yljacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-tetrazol-5-yl-1 ,3-butadienyl)indol-1 yljacetamide N-(4-methoxyphenethyl)-N-methyl-2-[5-benzyloxy-3-(2-tetrazol-5-ylethyl)indol- 1 -yljacetamide N-(4-methoxyphenethyl)-N-methyl-2-[4-benzyloxy-3-(2-tetrazol-5-ylethyl)indol- 1 -yljacetamide N-(4-methoxyphenethyl)-N-methyl-2-[7-benzyloxy-3-(2-tetrazol-5-ylethyl)indol- 1 -yljacetamide N-(4-methoxyphenethyl)-N-methyl-2-[5-(2-(N-methyl-N-phenethyl)amino-2- oxo)-3-(2-tetrazol-5-ylvinyl)ethoxy-indol-1-ylJ-acetamide N-(4-methoxyphenethyl)-N-methyl-2-[5-(4-methylbenzyloxy)-3-(2-tetrazol-5- ylvinyl)indol-1 -yljacetamide 1-benzyl-3-(2-tetrazol-5-ylethyl)-5-[2-(N-methyl-N-phenethyl)amino-2-oxoJ- ethoxyindole N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-yl)ethylindol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[4-benzyloxy-3-(2-tetrazol-5-ylpropyl)indol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-ylbutyl)indol-1 -ylj¬ acetamide N-methyl-N-phenethyl-2-[1 -benzyl-3-(2-tetrazol-5-ylpropyl)indol-5-ylJ- acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-ylpropyl)indol-1-ylJ- acetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-tetrazol-5-yl)butylindol-1 -ylj¬ acetamide Example 60 N-methyl-N-phenethyl-2-r5-benzyloxy-3-(4-carboxy- 3-methyl-3-butenv0indol-1 -yllacetamide Step A: N-methyl-N-phenethyl-2-[3-(2-acetvnvinyl-5-benzyloxyindol-1 -ylj¬ acetamide A mixture 2g (4.68 mmol) of N-methyl-N-phenethyl-2-[3-benzyloxy-2- formyiindol-1 -yljacetamide, 125 ml of acetone and 25 ml of 1 N aqueous sodium hydroxide solution is stirred at room temperature for 72 hours. The mixture is then concentrated in vacuo. The pH of the concentrated mixture is adjusted to about 6 with 1 N aqueous HCl solution. Ethyl acetate is added and the layers separated. The organic layer is washed with brine, dried over magnesium sulfate and concentrated in vacuo. The yellow foamy residue is triturated in ether/acetone to give N-methyl-N-phenethyl-2-[3-(2-acetyl)vinyl-5- benzyloxyindol-1 -yljacetamide. (m.p. 150-152°C) Step B: N-methyl-N-phenethyl-2-r3- ( 2-acetylethvn-5-benzyloxyindol-1 -ylj¬ acetamide When the procedure of Example 25 is followed, N-methyl-N-phenethyl- 2-[3-(2-acetyl)vinyl-5-benzyloxyindol-1 -yljacetamide is hydrogenated to N-methyl-N-phenethyl-2-[3-(2-acetylethyl)-5-benzyloxyindol-1 -yljacetamide. (m.p. 120-121 °C) Step C: N-methyl-N-phenethyl-2-[5-benzyloxy-3- ( 4-carbethoxy-3-methyl- 3-butenvπindol-1 -yllacetamide When the procedure of Example 22 is followed, N-methyl-N-phenethyl- 2-[3-acetylethyl-5-benzyloxyindol-1 -yljacetamide is reacted with triethylphosphonoacetate to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4- carbethoxy-3-methyl-3-butenyl)indol-1 -yljacetamide as a yellow oil which is NMR verified. Step D: N-methyl-N-phenethyl-2-f5-benzyloxy-3-(4-carboxy-3-methyl-3- butenvflindol-1 -yljacetamide When the procedure of Example 26 is followed, N-methyl-N-phenethyl- 2-[5-benzyloxy-3-(4-carbethoxy-3-methyl-3-butenyl)indol-1 -yljacetamide is hydrolyzed to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-carboxy-3- methyl-3-butenyl)indol-1 -yljacetamide as a yellow foamy substance. NMR confirms this structure. Example 61 N-methyl-N-phenethyl-2-(5-benzyloxy-2-carboxyindo[-1-vπacetamide N-methyl-N-phenethyl-2-(5-benzyloxy-3-carboxyindol-1 -vhacetamide Step A: N-methyl-N-phenethyl-2-(5-benzyloxy-2-carbomethoxyindol-1- vhacetamide Following the procedure of Example 10, 5-benzyloxy-2-carbomethoxy- indole is alkylated with N-methyl-N-phenethyl-2-bromoacetamide to give N-methyl-N-phenethyl-2-(5-benzyloxy-2-carbomethoxyindol-1 -yljacetamide. (m.p. 155-156°C) Step B: N-methyl-N-phenethyl-2-(5-benzyloxy-2-carboxyindol-1-vh- gςetamide Following the procedure of Example 23 the ester of Step A is hydrolyzed to give N-methyl-N-phenethyl-2-(5-benzyloxy-2-carboxyindol-1 -yl)acetamide. (m.p. 250°C (dec.)) Step C: N-methyl-N-phenethyl-2-(5-benzyloxy-3-carboxyindol-1-vh- acetamiςie When 5-benzyloxy-3-carbomethoxyindol is used in Step A and the alkylated product obtained is then hydrolyzed according to Step B, N-methyl-N- phenethyl-2-(5-benzyloxy-3-carboxyindol-1 -yljacetamide is prepared, (m.p. 182-1 δ5°C) Example 62 N-methyl-N-phenethyl-2-f5-benzyloxy-1- (2-carboxyvinvπindol-3-yljacetamide Step A: N-methyl-N-phenethyl-2-(5-benzyloxyindol-3-vπacetamide When the procedure of Example 14 is followed, 5-benzyloxyindole-3- acetic acid and N-methyl-N-phenethylamine are reacted to give N-methyl-N- phenethyl-2-(5-benzyloxyindol-3-yl)acetamide. (m.p. 146°C (dec.)) Step B: N-methyl-N-phenethyl-2-[5-benzyloxy-1 -(2-carbethoxyvinyhindol- 3-vljacetamide To a mixture of 1.579g (3.96 mmol) of N-methyl-N-phenethyl-2-(5- benzyloxyindol-3-yl)acetamide and 0.4 ml of benzyltrimethylammonium hydroxide (40% solution in methanol) in 15 ml of dioxane is added with stirring 0.44 ml (0.43g, 4.35 mmol) of ethyl propriolate. A reddish solution is obtained, which is stirred at room temperature for 1 δ hours and concentrated in vacuo. The residue is taken up in ethyl acetate, washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residue is purified by dry column chromatography over silica gel eluting with a solvent system of 5% ethyl acetate in methylene chloride to yield 450 mg of N-methyl-N-phenethyl-2- [5-benzyloxy-1 -(2-carbethoxyvinyl)indol-3-ylJacetamide. Step C: N-methyl-N-phenethyl-2-[5-benzyloxy-1-(2-carboxyvinvπindol-3- yljacetamide Following the procedure of Example 23 the ester of Step B is hydrolyzed to N-methyl-N-phenethyl-2-[5-benzyloxy-1-(2-carboxyvinyl)indol-3-ylj- acetamide. (m.p. 104-10δ°C (dec.)) Example 63 When pyrrolidine in the procedure of Example 24 is replaced with a suitable amine and N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxyvinyl)- indol-1 -yljacetamide is replaced by the acids prepared by the above examples, then the corresponding amide is prepared. Example 64 N-benzyl-5-benzyloxy-3-(2-tetrazol-5-ylethvnindole Step A: N-benzyl-5-benzyloxy-3-formylindole Following the procedure of Example 10, benzyl bromide is used in place of N-methyl-N-phenethyl-2-bromoacetamide to give N-benzyl-5-benzyloxy-3- formylindole. Step B: N-benzyl-5-benzyloxy-3-(2-cvanovinvπindole Following the procedure of Example 55, N-benzyl-5-benzyloxy-3- formylindole is treated with acetonitrile triphenylphosphonium bromide to give N-benzyl-5-benzyloxy-3-(2-cyanovinyl)indole. Step C: N-benzyl-5-benzyloxy-3-(2-tetrazol-5-ylvinvhindole Following the procedure of Example 56, N-benzyl-5-benzyloxy-3-(2- cyanovinyl)indole is reacted with the sodium azide to give N-benzyl-5- benzyloxy-3-(2-tetrazol-5-ylvinyl)indole. (m.p. 178-180°C (dec.)) Step D: N-benzyl-5-benzyloxy-3-(2-tetrazol-5-ylethvπindole Following the procedure of Example 57, N-benzyl-5-benzyloxy-3-(2- tetrazol-5-ylvinyl)indole is reduced to give N-benzyl-5-benzyloxy-3-(2-tetrazol- 5-ylethyl)indole. Example 65 N-methyl-N-phenethyl-2-IY5-benzyloxy-3- dimethylamidomethyπindol-1 -yljacetamide Step A: N-methyl-N-phenethyl-2-f ( 5-benzyloxy-3-carbomethoxymethvB- indol-1 -yllacetamide Following the procedure of Example 10 and using 5-benzyloxy-3- carbomethoxymethylindole in place of 5-benzyloxyindole-3-carboxaldehyde the product prepared is N-methyl-N-phenethyl-2-[(5-benzyloxy-3- carbomethoxymethyl)indol-1 -yljacetamide. Step B: N-methyl-N-phenethyl-2-f(5-benzyloxy-3-carboxymethylVmdol-1- yljacetamide Following the procedure of Example 26, N-methyl-N-phenethyl-2-[(5- benzyloxy-3-carbomethoxymethyl)indol-1 -yljacetamide is hydrolyzed to give N-methyl-N-phenethyl-2-[(5-benzyloxy-3-carboxymethyl)indol-1 -yljacetamide. Step C: N-methyl-N- p henethyl-2- 5-benzyloxy-3-dimethylamidomethvn- indol-1 -yllacetamide Following the procedure of Example 24, the acid from Step B is converted to the acid halide and treated with dimethylamine to obtain N-methyl-N-phenethyl-2-[(5-benzyloxy-3-dimethylamidomethyl)indol-1 -ylj¬ acetamide. Example 66 N-methyl-N-phenethyl-2-f(5-(2-methylphenethylamino- 2-oxotethoxy-3-diethylamidomethvπindol-1 -yllacetamide Step A: N-methyl-N-phenethyl-2-f ( 5- ( 2-methylphenethylamino-2-oxo - ethoxy-3-carbomethoxymethvhindol-1-vnacetamide Following the procedure of Example 10, 5-benzyloxyindole-3- carboxaldehyde is replaced with 5-[2-(N-methyl-N-phenethyl)amino-2-oxoj- ethoxy-3-carbomethoxy-methylindole to obtain N-methyl-N-phenethyl-2-[(5-(2- methylphenethylamino-2-oxo)ethoxy-3-carbomethoxymethyl)indol-1 -ylj¬ acetamide. Step B: N-methyl-N-phenethyl-2-f ( 5- ( 2-methyl p henethylamino-2-oxo - ethoxy-3-carboxymethvπindol-1 -yllacetamide Following the procedure of Example 26, the ester from Step A is hydrolyzed to give N-methyl-N-phenethyl-2-[(5-(2-methylphenethylamino-2- oxo)ethoxy-3-carboxymethyl)indol-1 -yljacetamide. Step C: N-methyl-N-phenethyl-2-r ( 5- ( 2-methylphenethyl-amino-2- oxotethoxy-3-diethylamidomethv indol-1 -yllacetamide Following the procedure of Example 24 the acid from Step B is converted to the acid halide and treated with diethylamine to obtain N-methyl- N-phenethyl-2-[(5-(2-methylphenethylamino-2-oxo)ethoxy-3-diethylamido- methyl)indol-1 -yljacetamide. Example 67 1 -benzyl-3-carboxymethyl-5-f2- N-methyl-N-phenethvπamino-2-oxolethoxyindole Step A: 3-carbomethoxymethyl-5-r2- ( N-methyl-N-phenethv amino-2- oxojethoxyindole Following the procedure of Example 2, 5-hydroxyindole is replaced by 3-carbomethoxymethyl-5-hydroxyindole to obtain 3-carbomethoxymethy!-5-[2- (N-methyl-N-phenethyl)amino-2-oxojethoxyindole. Step B: 1-benzyl-3-carbomethoxymethyl-5-r2-fN-methyl-N-Phenethvn- amino-2-oxolethoxyindole Following the procedure of Example 10 and reacting benzyl bromide with 3-carbomethoxymethyl-5-[2-(N-methyl-N-phenethyl)amino-2-oxoJ- ethoxyindole the product prepared is 1-benzyl-3-carbomethoxymethyl-5-[2-(N- methyl-N-phenethyl)amino-2-oxo]ethoxyindole. Step C: 1-benzyl-3-carboxymethyl-5-[2-(N-methyl-N-Phenethvhamino-2- oxojethoxyindole Following the procedure of Example 26 the ester from Step B is hydrolyzed to give 1-benzyl-3-carboxymethyl-5-[2-(N-methyl-N-phenethyl)- amino-2-oxo]ethoxyindole. Example 68 N-methvl-N-phenethvl-2-r(4-benzvloxv-3-carboxvtindol-1 -vl1acetamide When 5-hydroxyindole in the procedure of Example 3 is replaced with 3-carbethoxy-4-hydroxyindole and the resulting 3-carbethoxy-4-benzyloxy- indole is used in place of 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10, then the product obtained is N-methyl-N-phenethyl- 2-[(4-benzyloxy-3-carbethoxy)indol-1 -yljacetamide. When the latter is used in place of N-methyl-N-phenethyl-2-[(5-benzyloxy-3-formyl)indol-1 -yljacetamide then the product obtained is N-methyl-N-phenethyl-2-[(4-benzyloxy-3-carboxy)- indol-1 -yljacetamide. (m.p. 120-125°C) Example 69 N-methyl-N-phenethyl-2-(4-benzyloxy-3- (2-trans-carboxy-2-methyl inylindol-1 -vhacetamide Step A: N-methyl-N-phenethyl-2-(4-benzyloxy-3-formylindol-1 -vh- acetamide To a suspension of sodium hydride (1.31g, 80% suspension in mineral oil, 43.6 mM) in 65 ml of tetrahydrofuran (THF), cooled in an ice bath, is added dropwise a solution of 4-benzyloxyindole-3-carboxaldehyde (10.2g, 39.δ mM) in 55 ml of THF. The mixture is stirred in the cooling bath for an additional 30 minutes; N-methyl-N-phenethyl-2-bromoacetamide (15.3g, 59.7 mM) is then added. The resulting mixture is stirred at room temperature for 16 hours. Ethyl acetate and 50% brine is added and the layers are separated. The organic layer is washed with brine, dried over magnesium sulfate and concentrated in vacuo to give crude product as a beige oil. Purification on preparative HPLC (silica gel column, 20% ethyl acetate in methylene chloride) gives N-methyl-N- phenethyl-2-(4-benzyloxy-3-formylindol-1-yl)acetamide. (m.p. 120-122°C) Step B: N-methyl-N-phenethyl-2-(4-benzyloxy-3-(2-trans-carbethoxy-2- methyl inylindol-1-vπacetamide To a suspension of sodium hydride (0.259g, 80% suspension in mineral oil, 8.64 mM) in 20 ml of THF, cooled in an ice bath, is added dropwise 1.87g (7.65 mM) of triethyl 2-phosphonopropionate. The clear solution obtained in the reacting flask is stirred in the ice bath for an additional 10 minutes and a solution of N-methyl-N-phenethyl-2-(4-benzyloxy-3-formylindol-1 -yljacetamide (1.34g, 3.14 mM) in 20 ml of THF added quickly. The cooling bath is removed and the reaction mixture stirred at room temperature for 1δ hours. After quenching the reaction with a small amount of water, ethyl acetate and brine are added and the layers separated. The organic layer is washed with brine, dried (MgSθ4), and concentrated in vacuo to give a crude mixture as a brown oil. This material is purified by hplc on a silica gel column, using a one-to-one mixture of ethyl acetate and hexane as the solvent system, to give 0.δ9g of the pure N-methyl-N-phenethyl-2-(4-benzyloxy-3-(2-trans-carbethoxy-2-methyl- vinyl)indol-1-yl)acetamide. Also obtained from this hplc separation is 0.4δg of the cis-isomer and 0.05g of a mixture of the cj≤ and trans isomers confirmed by NMR. Step C: N-methyl-N-phenethyl-2-(4-benzyloxy-3-(2-trans-carboxy-2- methyl inylindol-1-vπacetamide To a solution of N-methyl-N-phenethyl-2-(4-benzyloxy-3-(2-trans- carbethoxy-2-methyl)vinylindol-1 -yljacetamide (0.7g, 1.37 mM) in 03 ml of ethanol is added a solution of potassium hydroxide (0.261g, 4.12 mM) in 7 ml of water. The resulting mixture is heated in an oil bath of 50°C for four days. After cooling to room temperature, the bulk of ethanol is removed in vacuo. The concentrated mixture is dissolved in water and extracted with diethyl ether. The aqueous layer is acidified with 1 N HCl to pH 6.5-7. The precipitate formed is extracted into ethyl acetate. The organic solution is washed with brine, dried (MgS04) and concentrated in vacuo to give N-methyl-N-phenethyl-2-(4- benzyloxy-3-(2-trans-carboxy-2-methyl)vinylindol-1 -yl)acetamide. (m.p. 199- 201 °C). Example 70 N-methyl-N-phenethyl-2-[5-benzoylamide- 3-(2-carboxyethvhindol-1 -yljacetamide Step A: N-methyl-N-phenethyl-2-(5-nitro-3-carboxaldehvdeindol-1 -vn- acetamide To a mixture of sodium hydride (1.9g, 76.9 mmol) in anhydrous tetrahydrofuran (200 ml) at 0°C is added portionwise 5-nitro-3- carboxaldehydeindole (15.0g, 7δ.9 mmol). The reaction is allowed to stir for 30 minutes. N-methyl-N-phenethyl-2-bromoacetamide (20.2g, 76.9 mmol) is added and the reaction stirred for 16 hours and then heated at reflux. After allowing to cool the solid is filtered off, the solvent is removed and the residue is crystallized from chloroform/hexane to give N-methyl-N-phenethyl-2-(5-nitro- 3-carboxaldehydeindol-1-yl)acetamide. (m.p. 200°C) Step B: N-methyl-N-phenethyl-2-f5-nitro-3-ft-butyl-2-carboxyvinvπindol-1- yljacetamide To a chilled solution of t-butyl diethylphosphono-acetate (5.4g, 21.4 mmol) in dimethylformamide (15 ml) sodium hydride (0.51 g, 21.4 mmol) is added portionwise. The reaction is allowed to come to ambient temperature and stirred for 1 hour. The aldehyde, N-methyl-N-phenethyl-2-(5-nitro-3- carboxaldehydeindol-1-yl)acetamide (5.2g, 14.2 mmol) is added portionwise. After 1 1/2 hours the reaction is poured into water (600 ml) and extracted with ethyl acetate (3 x 10). The ethyl acetate layer is dried (Na2Sθ4) and the solvent is removed. This gives a red oil which is crystallized for hexane/ethyl acetate to give N-methyl-N-phenethyl-2-[5-nitro-3-(t-butyl-2-carboxyvinyl)- indol-1 -yljacetamide. (m.p. 140-143°C) Step C: N-methyl-N-phenethyl-2-r5-benzoylamide-3-t-butyl-2- carboxyethvhindol-1 -yljacetamide A mixture of N-methyl-N-phenethyl-2-[5-nitro-3-(t-butyl-2-carboxyvinyl)- indol-1 -yljacetamide (0.9g, 1.9 mmol), tetrahydrofuran (30 ml), ethanol (30 ml), and palladium on carbon (10%, 0.2g) is shaken under hydrogen (45 psi). After 4 hours the mixture is filtered through celite and the solvent is removed. The residue is added to a solution of N-benzoylimidazole (5.8 mmol) in tetrahydrofuran (20 ml). After 16 hours the solvent is removed and methanol (50 ml) is added. The solution is allowed to stand for 1 1/2 and the methanol is removed. The oil is chromatographed using silica gel and an ethylacetate/ hexane 1 :1 solution until the methyl benzoate is removed. The solvent is changed to ethylacetate:hexane 2:1. This gives crude product which is crystallized from CHCI3/ ether/hexane to give N-methyl-N- phenethyl-2-[5-benzoyl-amide-3-(t-butyl-2-carboxyethyl)indol-1 -yljacetamide as a white solid, (m.p. 158-159°C) Step D: N-methyl-N-phenethyl-2-[5-benzoylamide-3-(2-carboxyethvπ- indol-1 -yllacetamide A solution of (0.25g, 0.46 mmol) of N-methyl-N-phenethyl-2-[5-benzoyl- amide-3-(t-butyl-2-carboxyethyl)indol-1 -yljacetamide is dissolved in trifluoroacetic acid/ methylene chloride (1 :1 , 6 ml). After stirring for 3 hours the solvent is removed and the residue is dissolved in a small amount of ethanol. Ethylether is added and the fluffy tan solid is filtered to give N-methyl-N- phenethyl-2-[5-benzoylamide-3-(2-carboxyethyl)indol-1 -yljacetamide. (m.p. 219-222°C) Example 71 1-f(N-methyl-N-(2-phenethyl 2-acetamidoJ-6-benzyloxy-3-naphthoic acid Step A: 3-carbomethoxy-4-(3-methoxyphenvπ-3-butenoic acid To a refluxing suspension of 15.71g (140 mmol, 1.4 eq) of potassium t-butoxide in 50 ml of t-butylalcohol is dropped in a mixture of 12.17 (100 mmol) of 3-methoxybenzaldehyde and 15.70 ml (120 mmol, 1.2 eq) of dimethyl succinate dissolved in 20 ml of t-butylalcohol. The mixture is refluxed for 3 hours, concentrated in vacuo. acidified to pH ~1 using 1 N HCl, and extracted with ethylacetate. The organics are dried (MgSθ4) and concentrated in vacuo to give 3-carbomethoxy-4-(3-methoxyphenyl)-3-butenoic acid in the form of a yellow oil which is used directly in the next step. Step B: 3-carbomethoxy-4- ( 3-methoxyphenv0butanoic acid A solution of 21.1 g (84 mrnol) of 3-carbomethoxy-4-(3-methoxyphenyl)- 3-butenoic acid in 100 ml of acetic acid with 2.11 g of 10% Pd on carbon is shaken under H2 atmosphere until H2 uptake ceases (approximately 4 hours). This is filtered through celite and the filtrate concentrated in vacuo several times from toluene to afford 17.6g of 3-carbomethoxy-4-(3-methoxyphenyl)- butanoic acid in the form of a yellow oil which is used directly in the next step. Step C: 3-carbomethoxy-6-benzyloxy-1-tetralin A solution of 14g (55.57 mmol) of 3-carbomethoxy-4-(3-methoxyphenyl)- butanoic acid in 200 ml of CH2CI2 is refluxed for 18 hours with 8.1 ml (110.99 mmol, 2 eq) of SOCI2 and 2 drops of DMF. After concentration in vacuo several times from CH2CI2, this is dissolved in 50 ml of 1 ,2-dichloroethane and dropped into a suspension of 22.19g (166.49 mmol, 3 eq) of AICI3 in 200 ml of 1 ,2-dichloro-ethane at 25°C. After refluxing for 3 hours, the cooled mixture is quenched with H2O, acidified to pH ~1 using 1 N HCl, and extracted with CH2CI2. The organics are dried (MgS04) and concentrated in vacuo. This is dissolved in 50 ml of DMF and heated at 60°C for 18 hours with 6 ml (47.68 mmol, 1.5 eq) of benzylbromide and 6.6g (47.68 mmol, 1.5 eq) of K2CO3. The mixture is partitioned between ethyl acetate and H2O. The organics are dried (MgSθ4) and concentrated in vacuo. This is purified by flash silica gel chromatography using 20% ethyl acetate in hexanes as an eluent to give 3.0g of 3-carbomethoxy-6-benzyloxy-1-tetralin in the form of a pale yellow crystalline solid, (m.p. 139-140°C) Step D: 3-carbomethoxy-6-benzyloxy-1-naphthol A solution of 3.4g (10.96 mmol) of 3-carbomethoxy-6-benzyloxy-1- tetralin and 3.5g (10.96 mmol) of pyridinium bromideperbromide in 30 ml of acetic acid is heated at 60°C for 1 hour. The mixture is partitioned between Et2θ and H2O. The organics are dried (MgSθ4) and concentrated in vacuo. The residue in 20 ml of DMSO is stirred for 1 hour with 3.69g (32.67 mmol, 3 eq) of potassium t-butoxide at 25°C. The mixture is acidified to pH 1 using 1 N HCl, then partitioned between ethyl acetate and H2O. The organics are dried (MgSθ4) and concentrated in vacuo. To the residue in 25 ml of CH2CI2 is added 1.95g (12.05 mmol, 1.1 eq) of carbonyl diimidazole and a catalytic amount of DMAP which is stirred at 25°C for 0.5 hours. This is then stirred for 1δ hours with 2 ml of MeOH. This is concentrated in vacuo and partitioned between ethyl acetate and 1 N HCl. The organics are dried (MgSθ4) and concentrated in vacuo. This is purified by flash silica gel chromatography using 15% ethyl acetate in hexanes as an eluent affords 0.50g of 3- carbomethoxy-6-benzyloxy-1-naphthol in the form of a white crystalline solid, (m.p. 179-180°C) Step E: 1-trifluoromethylsulfonyloxy-3-carbomethoxy-6-benzyloxy- naphthalene To 0.65g (2.11 mmol) of 3-carbomethoxy-6-benzyloxy-1-naphthol in 20 ml of pyridine at 0°C is added 0.43 ml (2.5 mmol, 1.2 eq) of trifluoromethane- sulfonic anhydride which is then stirred for 18 hours at 25°C. The mixture is concentrated in vacuo and partitioned between ethyl acetate and 1 N HCl. The organics are dried (MgSθ4) and concentrated in vacuo. Purification by flash silica gel chromatography using 7% ethyl acetate in hexanes as an eluent affords 0.5g of 1-trifluoromethylsulfonyloxy-3-carbomethoxy-6-benzyloxy- naphthalene in the form of a clear oil which is used directly in the next step. Step F: 1 -vinyl-3-carbomethoxy-6-benzyloxynaphthalene A solution of 0.5g (1.4 mmol) of 1-trifluoromethylsulfonyloxy-3- carbomethoxy-6-benzyloxynaphthalene in 20 ml of DMF is stirred at 25°C for 18 hours with 0.1 δg (4.27 mmol, 3 eq) of LiCI, 0.46 ml (1.57 mmol, 1.1 eq) of vinyl-tributyltin and 0.019g (0.03 mmol, 0.02 eq) bis(triphenyl-phosphine) palladium (II) chloride. The mixture is partitioned between ethyl acetate and 1 N HCl. The organics are dried (MgSθ4) and concentrated in vacuo. Purification by flash silica gel chromatography using 5% ethyl acetate in hexanes as an eluent affords 0.3g of 1-vinyl-3-carbomethoxy-6-benzyloxy- naphthalene in the form of a yellow oil which is used directly in the next step. Step G: 1 -hvdroxyethyl-3-carbomethoxy-6-benzyloxy-naphthalene A solution of 0.3g (0.9 mmol) of 1-vinyl-3-carbomethoxy-6- benzyloxynaphthalene and 0.9 ml (0.9 mmol) of 1.0 M BH3 » THF complex in 15 ml of THF is stirred at 25°C for 2 hours. To this is added 1 ml of H20, 1 ml of 1 N NaOH and 1 ml of 30% H2O2 which is then stirred at 25°C for 2 hours. The mixture is acidified to pH ~1 using 1N HCl and extracted with ethyl acetate. The organics are dried (MgSθ4) and concentrated in vacuo. Purification by flash silica gel chromatography using 15% ethyl acetate in hexanes as an eluent affords O.Oδg of 1-hydroxyethyl-3-carbomethoxy-6-benzyloxy- naphthalene in the form a yellow oil which is used directly in the next step. Step H: 3-carbomethoxy-6-benzyloxy-1-naphthyl acetic acid To a solution of O.Oδg (0.24 mmol) of 1-hydroxyethyl-3-carbomethoxy-6- beπzyloxynaphthalene in 10 ml of acetone at 0°C is added Jones reagent until a green precipitate forms. After stirring at 0°C for 10 minutes, the mixture is partitioned between ethyl acetate and H2O. The organics are dried (MgS04) and concentrated in vacuo to afford 0.081 g of 3-carbomethoxy-6-benzyloxy-1- naphthyl acetic acid in the form of a light tan solid which is used directly in the next step. Step I: 1-[(N-methyl-N-(2-phenethylV2-acetamidol-3-carbomethoxy-6- benzyloxynaphthalene A solution of 0.051 g (0.23 mmol) of 3-carbomethoxy-6-benzyloxy-1 - naphthyl acetic acid, 0.041g (0.25 mmol, 1.1 eq) of carbonyl diimidazole and a ' catalytic amount of DMAP is stirred at 25°C for 1 hour in 15 ml of CH2CI2. To this is added 0.037 ml (0.25 mmol, 1.1 eq) of N-methyl-N-phenethylamine which is then stirred at 25°C for 18 hours. The mixture is concentrated in vacuo. then partitioned between ethyl acetate and 1 N HCl. The organics are dried (MgSθ4) and concentrated in vacuo. Purification by thick layer prep plate chromatography developed in 10% acetone in hexanes affords 0.1 g of 1-[(N-methyl-N-(2-phenethyl)-2-acetamido]-3-carbomethoxy-6-benzyloxy- naphthalene in the form of a yellow oil which is used directly in the next step. Step J: 1-[(N-methyl-N-(2-phenethvn-2-acetamido1-6-benzyloxy-3- naohthoic acid A solution of 0.07g (0.15 mmol) of 1-[(N-methyl-N-(2-phenethyl)-2- acetamido]-3-carbomethoxy-6-benzyloxynaphthalene and 0.31 g (0.75 mmol, 5 eq) of lithium hydroxide monohydrate in 20 ml of a 1 :1 :1 mixture of THF:H2θ:MEOH is stirred at 25°C for 10 hours. The mixture is acidified to pH ~1 using 1 N HCl and extracted with ethyl acetate. The organics are dried (MgS04) and concentrated in vacuo. The residue is triturated with ET2θ/hexanes and the solid filtered off to afford 0.035g of 1-[(N-methyl-N-(2- phenethyl)-2-acetamido]-6-benzyloxy-3-naphthoic acid in the form of a white crystalline solid, (m.p. 76-79°C) Example 72 N-methyl-N-phenethyl-2-f5-benzyloxy-3- (2-carbethoxy-2-methylvinvπindol-1 -yljacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3- (2- fEVcarbethoxy-2-methylyinyl v ιindol-1 -yllacetamide N-methyl-N-phenethyl-2-[5-benzyloxy-3- (2-fZ carbethoxy-2-methylvinvπindol-1 -yllacetamide Following the procedure of Example 34, N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-1 -yljacetamide is prepared, (m.p. 128-130°C) This substance is further purified on a silica gel flash column, eluting with a solvent system of 2% ethyl acetate in methylene chloride to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-(E)-carbethoxy-2-methylvinyl)- indol-1 -yljacetamide and N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-(Z)- carbethoxy-2-methylvinyl)indol-1 -yljacetamide. NMR confirms these structures. Example 73 N-methyl-N-phenethyl-2-[4-benzyloxy-3- (2-carboxv-2-ethvlvinvnindol-1-vnacetamide When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)- indol-1 -yljacetamide in the procedure of Example 23 is replaced with N-methyl- N-phenethyl-2-[4-benzyloxy-3-(2-carboethoxyvinyl)indol-1 -yljacetamide then the product preared is N-methyl-N-phenethy!-2-[4-benzyloxy-3-(2- carboxyvinyl)indol-1 -yljacetamide as a white powder, (m.p. 170-174°C) Example 74 5-benzvloxv-3-(3-carbmethoxybenzov ndole To a solution 5-benzyloxyindole (2.23g, 10 mmol) in 5 ml of tetrahydrofuran (THF), cooled in an external ice bath, is added dropwise with stirring 6.15 ml of a 2 molar solution of methyl magnesium bromide in diethyl ether. The resulting mixture is stirred for an additional 15 minutes in the ice bath and a solution of 3-carbmethoxybenzoyl chloride in 10 ml of THF is added dropwise. The cooling bath is removed and the reaction mixture is stirred at room temperature for 18 hours. Water is then added, followed by ethyl acetate. The layers are separated. The organic layer is dried (MgSθ4) and concentrated in vacuo. The residue obtained is purified by a silica gel column, eluting with a solvent system of 25% ethyl acetate in hexane to give 5-benzyloxy-3-(3-carbomethoxybenzoyl)indole. NMR confirms this structure. Example 75 4-benzyloxy-3-carboethoχyphenylmethylindole When 5-benzyloxyindole and 3-carbomethoxybenzoyl chloride in the procedure of Example 74 are replaced by 4-benzyloxyindole and ethyl 2-bromophenylacetate, respectively, then the compound prepared is 4-benzyloxy-3-carboethoxyphenyimethylindole as an off-white powder, (m.p. 126-128°C) Example 76 5-benzyloxy-3-(3-carboethoxy-2-ρropenvπindole When 3-carbmethoxybenzoyl chloride in the procedure of Example 74 is replaced by ethyl 4-bromocrotonate then the compound prepared is 5-benzyloxy-3-(3-carboethoxy-2-propenyl)indole which is a beige oil. NMR confirms this structure. Example 77 N-methyl-N-phenethyl-2-f5-benzyloxy-3- (3-carbomethoxybenzovπindol-1 -yllacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 5-benzyloxy-3-(3-carbomethoxybenzoyl)indole, then the compound prepared is N-methyl-N-phenethyl-2-[5-benzyloxy-3-(3- carbomethoxybenzoyl)indol-1 -yljacetamide. This compound is recrystallized from ethyl acetate to give a beige crystal, (m.p. 224-230°C) Example 76 N-methyl-N-phenethyl-2-(4-benzyloxy-3- carboethoxyphenylmethylindol-1 -v acetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 4-benzyloxy-3-carboethoxyphenylmethylindole, then the compound prepared is N-methyl-N-phenethyl-2-(4-benzyloxy-3- carboethoxyphenylmethylindol-1-yl)acetamide. Example 79 N-methyl-N-phenethyl-2-r5-benzyloxy-3- (3-carboethoxy-2-propenvπindol-1 -yljacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 5-benzyloxy-3-(3-carboethoxy-2-propenyl)indole, then the compound prepared is N-methyl-N-phenethyl-2-[5-benzyloxy-3-(3- carboethoxy-2-propenyl)indol-1 -yljacetamide. NMR confirms this structure. Example 80 N-methyl-N-phenethyl-2-r5-benzyloxy-3- (3-carboxybenzoylVιndol-1 -yljacetamide N-methyl-N-phenethyl-2-r(4-benzyloxy-3- (1 -carboxy-1 -phenv methvhindol-1 -yllacetamide N-methyl-N-phenethyl-2-f5- benzyloxy-3-(3-carboxy-2-propenvhindol-1 -yllacetamide In a procedure similar to that described in Example 23, N-methyl-N- phenethyl-2-[5-benzyloxy-3-(carboethoxybenzoyl)indol-1 -yljacetamide is hydrolyzed to N-methyl-N-phenethyl-2-[5-benzyloxy-3-(carboxybenzoyl)indol- 1 -yljacetamide as a beige powder, (m.p. 224-230°C) Similarily, N-methyl-N-phenethyl-2-(4-benzyloxy-3-(1 -carboethoxy-1 - phenyl)methylindol-1-yl)acetamide is hydrolyzed to N-methyl-N-phenethyl-2- (4-benzyloxy-3-(1-carboxy-1-phenyl)methylindol-1-yl)acetamide as a white crystal, (m.p. 201-203°C) N-methyl-N-phenethyl-2-[5-benzyloxy-3-(3-carboethoxy-2-propenyl)- indol-1 -yljacetamide is hydrolyzed to N-methyl-N-phenethyl-2-[5-benzyloxy-3- (3-carboxy-2-propenyl)indol-1 -yljacetamide as an orange powder, (m.p. 150- 155°C (dec.)) Example 81 5-phenoxyindole-3-carboxaldehvde When N-methyl-N-phenethyl-2-(5-indolyloxy)acetamide in the procedure of Example 6 is replaced with 5-phenoxyindole, then the product obtained is 5-phenoxyindole-3-carboxaldehyde. NMR confirms this structure. Example 62 5-phenylindole-3-carboxaldehvde When N-methyl-N-phenethyl-2-(5-indolyloxy)acetamide in the procedure of Example 6 is replaced with 5-phenyl-indole, then the product prepared is 5-phenylindole-3-carboxaldehyde. NMR confirms this structure. Example 83 N-methyl-N-phenethyl-2-[(3-formyl-5-phenoxy)indol-1 -yljacetamide When 5-benzyloxyindole-3-carboxaldehyde in the procedure of Example 10 is replaced by 5-phenoxyindole-3-carboxaldehyde, then the compound prepared is N-methyl-N-phenethyl-2-[(3-formyl-5-phenoxy)indol-1 - yljacetamide. NMR confirms this structure. Example 84 Following the procedure of Example 10 the following compounds may be prepared: N-methyl-N-phenethyl-2-[(3-formyl-5-phenyl)indol-1 -yljacetamide; N-methyl-N-phenethyl-2-[(4-bromo-3-formyl)indol-1 -yljacetamide; and N-methyl-N-phenethyl-2-[3-formyl-4-(2-phenylvinyl)indol-1 -yljacetamide. NMR confirms these structures. Example 85 4-(2-phenylvinyl)indple When indole-4-carboxaldehyde is treated with the anion prepared from 2.5 molar equivalent of diethyl benzylphosphonate and sodium hydride, in a procedure similar to that described in Example 22, then the product prepared is 4-(2-phenylvinyl)indole. NMR confirms this structure. Example 86 4-(2-phenylvinvBindole-3-carboxaldehvde When 4-(2-phenylvinyl)indole is used in Example 6 the product prepared is 4-(2-phenylvinyl)indole-3-carboxaldehyde. NMR confirms this structure. Example 87 Following the procedure of Example 22 the following compounds may be prepared: N-methyl-N-phenethyl-2-[3-(2-carbethoxyvinyl)-5-phenoxyindol-1 -ylj¬ acetamide; N-methyl-N-phenethyl-2-[3-(2-carbethoxyvinyl)-5-phenylindol-1 -yljacetamide; N-methyl-N-phenethyl-2-[4-bromo-3-(2-carbethoxyvinyl)indol-1 -yljacetamide; and N-methyl-N-phenethyl-2-[3-(2-carbethoxyvinyl)-4-(2-phenylvinyl)indol-1-ylj- acetamide. NMR confirms these structures. Example 86 Following the procedure of Example 23 the following compounds may be prepared. N-methyl-N-phenethyl-2-[3-(2-carboxyvinyl)-5-phenoxyindol-1 -yljacetamide; N-methyl-N-phenethyl-2-[3-(2-carboxyvinyl)-5-phenylindol-1 -yljacetamide; N-methyl-N-phenethyl-2-[4-bromo-3-(2-carboxyvinyl)indol-1 -yljacetamide; and N-methyl-N-phenethyl-2-[3-(2-carboxyvinyl)-4-(2-phenylvinyl)indol-1-ylJ- acetamide. NMR confirms these structures. Example 89 Following the procedures of Examples 1-8δ the following compounds may be prepared. 4-[(N-methyl-N-phenethyl)carbamoylmethyl]-1 -benzyloxy-2-naphthoic acid (m.p. 55-60°C) 4-[(N-methyl-N-phenethyl)carbamoylmethyl]-8-benzyloxy-2-naphthoic acid (m.p. 181-183°C) 4-[(N-methyl-N-phenethyl)carbamoylmethyl]-8-phenyl-2-naphthoic acid (m.p. 175-177°C) 4-[(N-methyl-N-phenethyl)carbamoylmethyl]-δ-phenyl-2-(2-carboxy)- vinylnaphthalene (m.p. 159°C(dec.)) 2-(2-carboxy)ethyl-4-[(N-methyl-N-phenethyl)carbamoylmethyl]-8-phenyl- naphthalene (m.p. 79-80°C) 8-benzyloxy-2-(2-carboxy)vinyl-4-[(N-methyl-N-phenethyl)carbamoylmethylJ- naphthalene (m.p. 168-170°C) 5-benzyloxy-3-(4-carboxy-1 ,2-butadienyl)-1 -[(N-methyl-N-phenethyl)- carbamoylmethyl] naphthalene (m.p. 91 -100°C(dec.)) 5-benzyloxy-3-(4-carboxybutyl)-1-[(N-methyl-N-phenethyl)carbamoylmethylj- naphthalene (m.p. 110-113°C) 1 -[(N-methyl-N-phenethyl)carbamoylmethylJ-3-(2-methyl-2-carboxy)vinyl-5- benzyloxynaphthalene (m.p. 172-176°C) 5-benzyloxy-3-[(2-carboxy-2-ethyl)vinyl]-1-[(N-methyl-N-phenethyl)carbamoyl- methyljnaphthalene (m.p. 77-79°C) 4-[(N-methyl-N-phenethyl)carbamoylmethyl]-8-(2-quinoline-2-ylmethoxy)-2- naphthoic acid (m.p. 184-166°C) 4-[(N-methyl-N-phenethyl)carbamoylmethylj-8-(naphth-2-ylmethoxy)-2- naphthoic acid (m.p. 174-176°C) 4-[(N-methyl-N-phenethyl)carbamoylmethylj-δ-(pyridine-3-ylmethoxy)-2- naphthoic acid (m.p. 207-209°C) 5-benzyloxy-3-carboxy-1 -[(N-hydroxy-N-phenethyl)carbamoylmethylJ- naphthalene (m.p. 195-202°C)

Claims: WE CLAIM: 1. A bicyclic aryl compound having selective LTB4 antagonist properties and comprising an amido substituent, a substituent group having a terminal carboxylic acid or derivative thereof and a lipophilic substituent. 2. A compound according to Claim 1 where the bicyclic ring system is a 6,6 or 6,5 ring system of the formulae where T, U, V and W and T, U', V and W are selected from CR-| R2, NR3, O and S; provided that each ring of said bicyclic system contain 0-2 hetero atoms and said hetero atoms are not vicinal oxygen and/or sulfur atoms; X and Z are independently CRi R2, NR3, O or S; Y is CR-| R2 or NR3; Ri is hydrogen, alkyl or together with a vicinal Ri may form a carbon-carbon double bond or together with a vicinal R3 may form a carbon-nitrogen double bond; said amido substituent is either R2 or R3 of the formula substituted group ? ? — (C) d -D -(C) e -E I I is either R2 or R3 of the formula R R ; and said lipophilic R R I I — (C) f -F -(C) g -G substituent is either R2 or R3 of the formula _ R L R ' is hydrogen, alkyl, alkenyl, phenyl, alkoxy, amino, mono- and di-alkylamino, mercapto, alkylthio, halo or haloalkyl; R3 is hydrogen or alkyl; A is -CRR, O, S, NR', SO or SO2; B and G are each independently a substituted or unsubstituted monocyclic or bicyclic aryl; O R' II I D and F are each independently a bond, O, S, NR', SO, SO2, — c— N— , R' O I II -N-C- , -CRR, -0-(CRR)j-, -(CRR)j-O-, -0-(CRR)j-CR=CR-, -CR=CR-(CRR)j-0- where j is 1 -4, (CR=CR)χ where x is 0-2 or C≡C; -CON (CH 2 ) y E is -COOR', -CONR'R', ^^ where y is 2-5, -CN, -CONHS02R', N , tetrazo y or su st tute tetrazo yl where the substituent is alkyl, carboxyalkyl or carbalkoxyalkyl; R is hydrogen, -(CH2)m-R2» where m is 0-5 or together with a vicinal R group or vicinal R' group forms a 4-7 membered ring which may be saturated or partially unsaturated; R' is hydrogen, alkyl or aralkyl; a, b, d, e, f and g are independently 0-4 provided d+f+g+x≠O; or a pharmaceutically acceptable salt thereof. 3. A compound according to Claim 2 where the bicyclic aryl ring is X, Y and Z are CR1 R2 or NR3 provided at least one of X, Y and Z is CRi R2; T, U, V and W are CRi R2 or NR3 provided at least two of T, U, V and W are CR1 R2; Ri is hydrogen or together with a vicinal Ri may form a carbon-carbon double bond or together with a vicinal R3 may form a carbon-nitrogen double bond; R O R I II I A- (C) a — C -N (C) b — B I ■ 1 at least one of R2 or R3 is R R ' ~ ; at least one other of R R - (C) f -F -(C) g -G I R R - B and/or G may be optionally substituted with 1 to about 3 R" groups; and R" is alkyl, haloalkyl, alkoxy, halo or nitro. 4. A compound of the formula where: R O R ■ II I A- (C) a — C -N (C) b — B I I I at least one of R4, R5, R6, R7. Rδ. 9 or R10 is R R' R at least one of R4, R5, R6. R7. Rδ. R9 or R10 is R R I I — (C), -F -(C) g -G ■L ' one of R4, R5, Re, R7, Rδ. Rg or R10 is R R ; the remaining R4, R5. R6. R7. Rδ. R9 and R10 groups are hydrogen; A is -CRR or O; B is phenyl or substituted phenyl where the substituents are alkyl, haloalkyi, alkoxy or halo; D is a bond, O, -CRR, -0-(CRR)j-, -(CRR)j-O-, -0-(CRR)j-CR=CR-, -CR=CR- (CRR)j-O- where j is 1-4, or -(CR=CR)χ where x is 1 or 2; -CON (CH 2 ), E is -COOR', -CONR'R', \*^ where y is 2-5, -CN, -CONHS02R', tetrazolyl or substituted tetrazolyl where the substituent is alkyl, carboxyalkyl or carbalkoxyalkyl; F is a bond, O, -CRR, -NR' or -(CR=CR) X where x is 0-2; G is phenyl or substituted phenyl where the substituents are alkyl, haloalkyi, alkoxy or halo; R is hydrogen or -(CH2)m-R2 where m is 0-5; R2 is hydrogen, alkyl, alkenyl, phenyl, alkoxy, amino, mono- and di-alkylamino, mercapto, alkylthio, halo or haloalkyi; R' is hydrogen, alkyl or aralkyl; and a, b, d, e, f and g are independently 0-4; or a pharmaceutically acceptable salt thereof. 5. A compound according to Claim 4 where A is CHR or O; B and G is phenyl or substituted phenyl where the substituents are loweralkyl or loweralkoxy; D is a bond, O, -CHR, -0-(CRR) j -, -(CRR) j -O-, -0-(CRR) r CR=CR-, -CR=CR-(CRR) j -0- where j is 1-4, or (CR=CR)χ where x is 1 or 2; E is -COOR' or tetrazolyl; F is a bond, O or -CHR; R is hydrogen, loweralkyl or aryl; R' is hydrogen, loweralkyl or arloweralkyl; and a, b, d, e, f and g are independently 0-4. R O R I II I A- {C) a — C -N (C) b — B I I I 6. A compound according to Claim 5 where R R' R or lower alkyl and ϊ ~ — (C) d -D -(C),-E I I R" is hydrogen, lower alkyl or lower alkoxy; R R is selected from -(CRR)d-(CRR) e -E where d and e are 0-4, -(CR=CR) X -E where x is 1 -2, -0-(CRR)j-(CRR) e -E where d and e are 1-4, and -0-(CRR)j-CR=CR-E where j is 1-4 and where R is hydrogen or lower alkyl and E is -COOH or ; and g is 0-4 where R is hydrogen or lower alkyl and R" is hydrogen, lower alkyl or lower alkoxy. 7. A compound according to Claim 6 where R4 is R 0 R R R I II I 1 I —A- (C) a — C — N —(C) b -B — (C) d — D -(C), -E I I I I I R R' R ; Rβ is R R ; Rδ is R R — (C) f -F -(C) S -G R R ; and R5, R7, R9 and R10 are all hydrogen, δ. A compound according to Claim 6 where R4 is R 0 R R 1 II I 1 I —A- (C) a — C -N -(C) b -B — (C) d -D -(C) e -E ι i ι 1 1 R R' R ; R6 is R R ; R7 is R R — (C) f -F -(C) g -G i 1 8 R R ; and R5, Rδ, R9 and R10 are all hydrogen. 9. A compound according to Claim 7 which is N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-carboxyvinyl)indol-1-ylJ-acetamide or a pharmaceutically acceptable salt thereof. 10. A compound according to Claim 9 which is the cj≤ isomer. 11. A compound according to Claim 9 which is the trans isomer. 12. A compound according to Claim 7 which is N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-carboxy-2-methylvinyl)indol-1 -yljacetamide or a pharmaceutically acceptable salt thereof. 13. A compound according to Claim 12 which is the cj≥ isomer. 14. A compound according to Claim 12 which is the trans isomer. 15. A compound according to Claim δ which is N-methyl-N-phenethyl-2-[4- benzyloxy-3-(2-carboxyvinyl)indol-1 -yljacetamide or a pharmaceutically acceptable salt thereof. 16. A compound according to Claim 15 which is the cj≤ isomer. 17. A compound according to Claim 15 which is the trans isomer. 18. A compound according to Claim 8 which is N-methyl-N-phenethyl-2-(4- benzyloxy-3-(2-carboxy-2-methylvinyl)indol-1 -yljacetamide or a pharmaceutically acceptable salt thereof. 19. A compound according to Claim 18 which is the cj≤ isomer. 20. A compound according to Claim 18 which is the trans isomer. 21. A compound according to Claim 6 which is N-methyl-N-phenethyl-2-(5- benzyloxy-2-carboxyindol-1 -yl)acetamide or a pharmaceutically acceptable salt thereof. 22. A compound according to Claim 7 which is N-methyl-N-phenethyl-2-[5- benzyloxy-3-(2-carboxy-2-ethylvinyl)indol-1 -yljacetamide or a pharmaceutically acceptable salt thereof. 23. A compound according to Claim 22 which is the cj≥ isomer. 24. A compound according to Claim 22 which is the trans isomer. 25. A compound according to Claim 8 which is N-methyl-N-phenethyl-2-[(4- benzyloxy-3-carboxy)indol-1 -yljacetamide or a pharmaceutically acceptable salt thereof. 26. A compound according to Claim 7 which is N-methyl-N-phenethyl-2-[5- phenoxy-3-(2-carboxyvinyl)indol-1-ylJ-acetamide or a pharmaceutically acceptable salt thereof. 27. A compound according to Claim 7 which is N-methyl-N-phenethyl-2-[5- phenyl-3-(2-carboxyvinyl)indol-1 -yljacetamide or a pharmaceutically acceptable salt thereof. 79 28. A compound of the formula where: at least one of Ri 1 , Ri 2. Ri 3. Ri 4. i 5. i 6. R17 or Ri 8 is R R I I -A- (C) β - ■ C— N- ■ (C) b — B I I I R R' R at least one of is Ri 1 , Ri 2, R13. Ri 4. Ri 5, Ri 6. Ri 7 or R 8 is ϊ ? -(C) d -D-(C) β -E R andatleastoneof R11, R12. R13, R14, R15, R16. R R — (C) f -F-(C) g - Rl7or Riδis k ;the remaining Rn, R12, R13. R14. R15. R16. R17 and R18 groups are hydrogen; A is -CRR or O; B is phenyl or substituted phenyl where the substituents are alkyl, haloalkyi, alkoxy or halo; D is a chemical bond, O, -CRR, -0-(CRR)j-, -(CRR)j-0-, -0-(CRR)j-CR=CR-, -CR=CR-(CRR)j-0- where j is 1-4, or -(CR=CR) X where x is 1 or 2; -CON (CH 2 ) V E is -COOR', -CONR'R', \^ where y is 2-5, -CN, -CONHSO2R', tetrazolyl or substituted tetrazolyl where the substituent is alkyl, carboxyalkyl or carbalkoxyalkyl; F is O, -CRR, -NR' or -(CR=CR)χ where x is 0-2; G is phenyl or substituted phenyl where the substituents are alkyl, haloalkyi, alkoxy or halo; R is hydrogen or -(CH2)m-R2 where m is 0-5; R2 is hydrogen, alkyl, alkenyl, phenyl, alkoxy, amino, mono- and di-alkylamino, mercapto, alkylthio, halo or haloalkyi; R' is hydrogen, alkyl or aralkyl; and a, b, d, e, f and g are independently 0-4; or a pharmaceutically acceptable salt thereof. 29. A compound according to Claim 28 which is 4-[(N-methyl-N-phenethyl)- carbamoylmethyl]-7-benzyloxy-2-naphthoic acid or a pharmaceutically acceptable salt thereof. 30. A compound according to Claim 28 which is 4-[(N-methyl-N-phenethyl)- carbamoylmethylJ-7-benzyloxy-2-naphthoic acid or a pharmaceutically acceptable salt thereof. 31. A compound of the formula where A is -CRR; B and G are each independently selected from the group consisting of monocyclic or bicyclic aryl ring systems which may be optionally substituted with one to about three R" groups; F is selected from the group consisting of O, S, NR', SO, O R' R * O II I I II SO2, -C-N- -N-c- -CRR, (CR=CR) X where x is 1-2 or C≡C; R is hydrogen or -(CH2)m-R2 where m is 0-5; R2 is selected from the group consisting of hydrogen, alkyl, alkenyl, phenyl, alkoxy, amino, mono- and di-alkylamino, mercapto, alkylthio, halo or haloalkyi; vicinal R groups together and/or vicinal R and R' groups together may be -(CH2)n- where n is 2-5, thus forming a 4-7 membered ring which may br saturated or partially unsaturated; R' is hydrogen, alkyl or aralkyl; R" is independently hydrogen, alkyl, haloalkyi, alkoxy, halo or nitro; a, b, f and g are independently 0-4; or salts thereof. R O R I II I —A- (C) a — C -N -(C) b -B I l t I 32. A compound according to Claim 26 where R R' R is selected from and where R' is hydrogen or lower alkyl and R R ■ I — (C) f -F -(C) g -G R H is hydrogen, loweralkyl or loweralkoxy; and I R R - is selected from where g is 1-4 and where g is 1 -4 and where R is hydrogen or lower alkyl and R" is hydrogen, loweralkyl or loweralkoxy. 33. A compound according to Claim 27 of the formula 34. A compound according to Claim 30 which is N-methyl-N-phenethyl-2-(4- benzyloxy-3-formylindol-1-yl)acetamide. 35. A method for the treatment of hypersensitive ailments in humans and mammals comprising administering thereto an effective amount of a compound of the formula according to Claim 1. 36. A method for the treatment of inflammatory diseases in humans and mammals comprising administering thereto an effective amount of a compound of the formula according to Claim 1. 37. A method according to Claim 36 where the inflammatory disease is inflammatory bowel disease. 38. A pharmaceutical composition wherein the active ingredient is a compound according to Claim 1 in admixture with a pharmaceutical carrier.

Inventors: CHAN WAN K, GALEMMO ROBERT A JR, HUANG FU-CHIH, SUTHERLAND CHARLES A, CHAN, WAN, K., GALEMMO, ROBERT, A., JR., HUANG, FU-CHIH, SUTHERLAND, CHARLES, A.
Applicants: RHONE POULENC RORER INT, RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.
Application year: 1991
Main classification: A61K31
IPC codes: A61K31, A61P3, A61P25, A61P29, C07C235, C07C259, C07D209, C07D213, C07D215, C07D257, C07D263, C07D403, C07D471, C07D473