INDANO PYRROLIDINE CARBAMATES

Abstract: Compounds of formula (I) wherein W is (a) or (b) and R<7>, R<8>, R<9>, R<10>, R<11>, R<6>, R<5> and R<1> are as described herein.

Description: INDANO PYRROLIDINE CARBAMATES Background of the Invention The present invention relates to indano-pyrrolidine carbamates. The compounds of the present invention inhibit brain aσetylcholinesterase and are useful in the treatment of Alzheimer's disease. Moreover, intermediates of the compounds are useful as analgesic agents. The increasing average age in the United States and most other developed nations has given rise to an alarming upswing in the incidence of Alzheimer's disease. Among the compounds being considered for use in treating Alzheimer's disease are physostigmine and derivatives thereof. The preparation and use of such compounds is referred to in M. Brufani et al., Eur. J. Biochem.. 157, 115-120 (1986); Q.-S. Yu and A. Brossi, Heterocycles, 27, 745-750 (1988); European Patent Application Publication Number 0154864; European Patent Application Publication Number 0253372; K.L. Davis and R.c. Mohs, Am. J. Psychiatry, 139, 1421-1424 (1982); J.R. Atack et al.. The Journal of Pharmacology and Experimental Therapeutics, 249, 194-202 (1989); R.G Longnecker, Spectrum: Pharmaceuticals Products and Technologies, April 1988, pages 1-39 to 1-45; and United States Patent Application No. 166,824, filed March 4, 1988, published by the National Technical Information Service. Summary of the Invention The present invention relates to compounds of the formula I wherein is R 1 is hydrogen, (Cj to C 8 ) alkyl, (C^ to C 8 ) cycloalkyl (Cj to C 4 )alkyl, (C x to C 8 ) alkenyl, phenyl, substituted phenyl, phenyl(Cj to C 4 )alkyl, substituted phenyl (C j to C 4 )alkyl or heteroaryl (Cj to C 6 )alkyl wherein the heteroaryl groups are selected from pyridyl, thienyl or furanyl; R 3 and R 4 are independently hydrogen, (C x to C 8 )alkyl, hydroxy, (Cj to C 8 )alkoxy, halogen (e.g., fluoro, chloro, bromo or iodo) , amino, alkyla ino or dialkylamino, wherein the groups on the alkyl and dialkylamino are independently (Cj to C 6 )alkyl; R 5 , R 6 and R 8 , are each independently hydrogen, (Cj to C 8 )alkyl, phenyl, substituted phenyl, phenyl (C^-C alkyl, halogen (e.g., fluoro, chloro, bromo or iodo), nitro, amino, alkylamino, dialkylamino, (C j -C^)alkyl substituted with one to three fluoro (e.g., trifluoromethyl) , cyano, or COOR 12 wherein R 12 is C x to C n alkyl; R 7 is OH, SH, 0(Cj to C 4 )alkyl, S(C ! -C 4 )alkyl, 0C0NR 13 R 14 , SC0NR 13 R 14 or 0CSNR 13 R 14 , wherein R 13 and R 14 are independently hydrogen, C t to C n alkyl, (C 3 to C 7 )cycloalkyl (Cj to C 8 )alkyl, (C t to C 12 )- alkenyl, phenyl, substituted phenyl, phenyl (C t to C 8 )alkyl, substituted phenyl (Cj to C 8 )alkyl, heteroaryl, heteroaryl C x to c 8 )alkyl wherein said heteroaryl is selected from pyridyl, thienyl, furanyl, benzimidazolyl, thiazolyl, benzothiazolyl or R 13 and R 14 taken together with the nitrogen to which they are attached forms a 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl; R 9 is hydrogen, (C x to C 8 ) alkyl, (C x to C 8 )alkoxy, hydroxy; R 10 and R n are independently hydrogen, (Cj to C 6 )alkyl, phenyl, benzyl; and pharmaceutically acceptable acid addition salts thereof. As used herein and unless indicated otherwise, the term alkyl includes straight chain, branched and cyclic groups as well as alkyl groups having combinations of straight chain, branched and cyclic portions; the term alkenyl includes groups having straight chain, branched and cyclic structures or combinations thereof; and the term halogen includes fluoro, chloro, bromo and iodo. The present invention also relates to pharmaceutical composition for the treatment of Alzheimer's disease comprising a compound of the formula I and to the use of compounds of the formula I in treating Alzheimer's disease. The present invention also relates to intermediates of the compounds of the formula I. Preferred are those compounds wherein R 1 is hydrogen, methyl, ethyl, propyl, allyl, benzyl; R 7 is 0C0NR 13 R 14 or 0CSNR I3 R 14 ; where R 13 and R 14 are each independently H, (C j -C 12 ) alkyl, benzyl, phenyl or the group -NR 13 R 14 taken as a whole is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl; and R 9 is methyl or hydrogen. Preferred are those compounds wherein R 1 is methyl, R 9 is methyl and R 7 is OCONR 13 R 14 with R 13 and R 14 each independently H or alkyl. Also preferred are those compounds wherein R 1 is ethyl, R 9 is methyl and R 7 is OCONR 13 R 14 with R 13 and R 14 each independently H or Cj-C 7 alkyl. Preferred also are those compounds wherein R 1 is propyl R 9 is methyl and R 7 is as previously defined. Preferred are those compound wherein R 1 is benzyl, R 9 is methyl and R 7 is as previously defined. Specific preferred compounds of the present invention are the following: (+/")-1 / 2,3,3 ,8,8a-hexahydro-l-ethyl-3a-methyl-in- deno[2,l-b]pyrrol-5-ol, heptyl carbamate ester; (-)-1,2,3,3a,8,8a-hexahydro-l-ethyl-3a-methyl-in- deno[2,l-b]pyrrol-5-ol, heptyl carbamate ester; (+)-1,2,3,3a,8,8a-hexahydro-l-ethyl-3a-methyl-in- deno[2,l-b]pyrrol-5-ol, n-heptyl carbamate ester; (+/-)-l,2,3,3a,8,8a-hexahydro-l-ethyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, n-hexyl carbamate ester; (-)-l,2,3,3a,8,8a-hexahydro-l-ethyl-3a-methyl-in- deno[2,l-b]pyrrol-5-ol, n-hexyl carbamate ester; (+) -1,2,3 ,3a,8,8a-hexahydro-l-ethyl-3a-methyl-in- deno[2,l,b]pyrrol-5-ol, n-hexyl carbamate ester; (+/-) -1, 2 , 3 , 3a, 8 , 8a-hexahydro-l-ethyl-3a-methyl-in- deno[2-l-b]pyrrol-5-ol, n-butyl carbamate ester; (+/-) -1,2,3, 3a, 8 , 8a-hexahydro-l-ethyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, n-propyl carbamate ester; (+/-)-l,2,3, 3a,8,8a-hexahydro-l-ethyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, methyl carbamate ester; (+/-) -ι, 2, 3, 3a,8,8a-hexahydro-l-ethyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, phenyl carbamate ester; (+/-) -1,2,3, 3a, 8 , 8a-hexahydro-l-ethyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, benzyl carbamate ester; (+/-) -1,2,3, 3a, 8 , 8a-hexahydro-l-ethyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, (S)- methylbenzyl carbamate ester; (+/-) -1 , 2 , 3 , 3a , 8 , 8a-hexahydro-l , 3a-dimethyl-indeno- [2,l-b]pyrrol-5-ol, n-heptyl carbamate ester tosylate salt; (+/-)-l,2,3,3a,8, 8a-hexahydro-l, 3a-dimethyl-in- deno[2,l-b]pyrrol-5-ol, n-hexyl carbamate ester; (+/-) -1,2,3, 3a, 8 ,8a-hexahydro-l-n-propyl-3a-methyl-in- deno[2,l-b]pyrrol-5-ol, n-heptyl carbamate ester; (+/-) -1, 2 , 3 , 3a, 8 , 8a-hexahydro-l-benzyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, methyl carbamate ester; (+/-)-l,2,3,3a, 8,8a-hexahydro-l-benzyl-3a-methyl- indeno[2,l-b]pyrrol-5-ol, n-heptyl carbamate ester; [+/-]-l,2,3,3a,8, 8a-hexahydro-l-propyl-indeno- [2,l-b]pyrrol-5-ol, n-heptyl carbamate ester; [+/-]-l,2,3,3a,8, 8 -hexahydro-l-propyl-indeno- [2,l-b]pyrrol-5-ol, n-hexyl carbamate ester; [+/-]-l,2,3,3a,8, 8a-hexahydro-l-methyl-indeno- [2,l-b]pyrrol-5-ol, heptyl carbamate ester; [+/-]-l,2,3,3a,8, 8 a-hexahydro-1 -methyl- indeno- [2,l-b]pyrrol-5-ol, hexyl carbamate ester; (+/-)-l,2,3,3a,8, 8a-hexahydro-l-ethyl-indeno- [2,l-b]pyrrol-5-ol, heptyl carbamate ester; (+/-)-l,2,3,3a,8, 8 -hexahydro-l-ethyl-indeno- [2,l-b]pyrrol-5-ol, propyl carbamate ester; (+/-)-l,2,3,3a,8, 8a-hexahydro-l-n-propyl-3a-methyl- indeno [2,1, b] pyrrol-5-ol ; n-hexyl carbamate esters ; (-)-1,2,3,3a,8,8a-hexahydro-l-propyl-3a-methyl-indeno- [2,1, ]-pyrrol-5-ol, n-heptyl carbamate ester; (+/-)-1,2,3,3a,8,8a-hexahydro-l-ethyl-indeno[2,1-b]- pyrrol-5-ol, butyl carbamate ester; (+/-)-ι,2,3,3a,8,8a-hexahydro-l-ethyl-indeno[2,1-b]- pyrrol-5-ol, hexyl carbamate ester; Preferred compositions of the present invention contain the foregoing preferred compounds. More preferred compositions of the present invention contain the foregoing more preferred compounds and specific preferred compounds. The present invention is also directed to a compound of the formula: wherein R 1 is hydrogen, (C, to C 8 )alkyl, (C, to C 8 )cycloalkyl (Cj to C)alkyl, (Ci to C 8 )alkenyl, phenyl, substituted phenyl, phenyl (C x -C 4 )alkyl, substituted phenyl (Cj to C 4 )alkyl or heteroaryl (C, to C 6 )alkyl wherein the heteroaryl groups are selected from pyridyl, thienyl, and furanyl; R 3 and R 4 are each hydrogen, R 5 , R 6 and R 8 are each independently hydrogen, (Cj to C 8 )alkyl, phenyl, phenyl, substituted phenyl, phenyl(Cj to C 4 )alkyl, halogen (e.g., fluoro, chloro, bromo or iodo) , nitro, amino, alkylamino, dialkylamino, (Q x to C 4 )alkyl substituted with one to three fluoro (e.g., trifluoromethyl) , cyano, or C00R 12 wherein R 12 is Q. x to C n alkyl; R 7 is 0(Cj to C 4 )alkyl, S(Cj to C 4 )alkyl, R 10 and R 11 are independently hydrogen, (Cj to C 6 )alkyl, phenyl, benzyl; and pharmaceutically acceptable acid addition salts thereof, provided that R 1 and R 9 are not both methyl and R 7 is not 0CH 3 . -6- The present invention is also directed to a compound of the formula: wherein R 1 is hydrogen, (C } to C 8 )alkyl, (C j to C 8 )cycloalkyl (Cj to C 4 )alkyl, C t to C 8 )alkenyl, phenyl, substituted phenyl, phenyl (Cι~C 4 )alkyl, substituted phenyl (C j to C 4 )alkyl or heteroaryl (Cj to C 6 )alkyl wherein the heteroaryl groups are selected from pyridyl, thienyl, and furanyl; R 3 and R 4 are each hydrogen; R 5 , R 6 and R 8 are each independently hydrogen, (C x to C 8 )alkyl, phenyl, phenyl, substituted phenyl, phenyl(C } to C 4 )alkyl, halogen (e.g., fluoro, chloro, bromo or iodo) , nitro, amino, alkylamino, dialkylamino, (C x to C 4 )alkyl substituted with one to three fluoro (e.g., trifluoromethyl) , cyano, or COOR 12 wherein R 12 is C j to C 12 alkyl; R 10 and R π are independently hydrogen, (Cj to C 6 )alkyl, phenyl, benzyl; Y is O or S; and pharmaceutically acceptable acid addition salts thereof. The present invention is also directed to a pharmaceutical composition wherein Y is a readily hydrolyzable group. Examples of readily hydrolyzable groups include the prodrug form, for example, where Y is hydrolyzable in vivo, i.e. 0-acetate, OCOR 1 , OCHR^COR, OCOOR, and OCH 2 OCOOR wherein R and R 1 are as previously described. Detailed Description of the Invention Compounds of the present invention, wherein W is may be prepared as described below. Scheme I Preparation of 5-methoxy-tetrahydro-l-indenor2.1-bl pyrrol- 2(lIO-one Method A Scheme I (Continued) Method B Scheme II Reduction and N-alkylation Method A Scheme II (Continued) Reduction and N-alkylation Method B XV-a XHI-a, R 3 , R 4 are hydrogen R 3 t, R 4 are hydrogen Scheme III Preparation of Carbamate and Thiocarbamate XIV XVI R 19 =R 18 0 or R 18 S- Y=0 or S I X and Y are each independently 0 or S Scheme IV Optical Resolution Method B XIV or I was resolved with chiral acid Method C (R 21 is an optically active group uith at 1) Separation of tuo least one chiral center ) diasteπsomers 2) Hydrolysis with NaOH or LiOH or KCN in nethanol at at temperature between 70 C to 120 C XHI-fl + XIII-B Scheme I: Method A a) In the first step, a compound of formula II is reacted with an organometallic (i.e. methyl magnesium bromide) In a reaction inert solvent (THF) followed by quenching with a suitable acid (HC1) to yield compound III. b) A compound of the formula III then undergoes [2+2] cycloaddition with a suitable ketene i.e. dichloro- ketene, to afford a compound of formula IV. c) Reduction of IV with Zn yields compound V-a. Alkylation of the anion of V-a with an alkyl halide affords compound V-b. Compound V-b also can be prepared by an Aldol condensation of V-a with an aldehyde (R^CHO wherein R 22 CH 2 is R 10 ) , followed by elimination and reduction (hydrogenation in the presence of Pt0 2 or Pd/C at 1-5 atm in protic or aprotic solvents, e.g., ethanol, THF, ethyl acetate, etc.). d) Beckmann rearrangement of VI yields formula Vll-a. Method B a) Formula X can be prepared via an oxime formation [(Cj to C 6 )alkyl nitrite in an aprotic solvent, preferably ether, THF, in the presence of gaseous HC1] followed by hydrogenation [in the presence of Pd/C at 1-6 atm in acid, preferably Acetic acid/gaseous HC1 or in alcohol (e.g., ethanol) in the presence of gaseous HC1 starting from compound VIII. b) When R 3 and R 4 are both hydrogen, formula VII can be obtained by hydrogenation (Pd/C in Acetic acid 3-6 atm at 50-100°C, preferably at 3 atm at 70°C) of formula X. c) When R 3 =H and R=OH, formula VII can be prepared by reduction (e.g., sodium borohydride in alcohol, or lithium aluminum hydride in ether or THF) or hydrogenation (Pd/C at 1-4 atm in ethanol or acetic acid at room temperature) of formula X. Further alkylation of the hydroxy with an alkyl halide to give (C. to C 8 )alkoxy for the R 4 group in formula VII. d) When R 3 =H and R 4 =halogen (Cl, Br, or I), formula VII can be prepared from formula VIII (wherein R 3 =H and R 4 =OH) according to the methods described in H. House, Modern Synthetic Reactions, 2nd Ed., 1972, p 452-459; when R 4 =F, compound VII can be prepared from VIII (R 4 =OH) with dialkyaminosulfur trifluoride, or reaction of VIII (R 4 =OMs, OTs, or halogen) with tetrabutylammonium fluoride in aprotic solvent (e.g., methylene chloride, chloroform, THF, etc.). e) When R 3 =H and R 4 =amino, alkylamino or dialkylamino, compound VII can be prepared by reacting of X with an amine, alkylamine, or dialkylamine in the presence of sodium borohydride or sodium cyanoborohydride in alcohol, THF, water or acetic acid at temperature between 20°C to 100°C. Scheme II Method A a) Compound XI can be prepared from compound VII by reduction (lithium aluminum hydride in THF or ether at temperature between 20°C to 100°C, preferably at 50-70°C; or borane-tetrahydrofuran complex in THF at a temperature between 20°C to 100°C, preferably at 50-70 β C) . b) Compound XII can be prepared from formula XI by acylation with acylating agents (such as acetic anhydride, acetyl chloride, propionyl chloride, benzolyl chloride in the presence of a base such as pyridine or triethylamine in an inert solvent such as tetrahydrofuran, methylene chloride or chloroform at a temperature from about 20°C to 100°C) , followed by reduction with lithium aluminum hydride or borane-methyl sulfide complex in an inert solvent, preferably in THF or ether at 20°C to 100°C, preferably at 70 β C. Compound XII (R^Me) can also be prepared by hydrogenation (Pd/C in alcohol at 1-5 atm at 20°C) in the presence of 37% formaldehyde in alcohol, preferably ethanol or methanol. c) In an alternative method, compounds of formula XII can be prepared by alkylation of VII in the presence of a base such as sodium hydride, sodium alkoxide, followed by reduction in a similar manner to that described above. d) XIV can be prepared by reacting of XV with a Grignard reagent in an inert solvent such as THF or ether at -78°C to 50°C, preferred at -20 β C to 20°C, followed by reduction with a reducing agent such as sodium borohydride, sodium cyanoborohydride or lithium aluminum hydride. Method B a) XHI-a (R U =H) can be prepared directly from VI by reacting with diisobutylaluminum hydride according to the procedure set forth in (Tetrahedron Lett., 24, 4711, 1983). b) Xlll-a (R u =alkyl, phenyl or benzyl) can be prepared by Beckmann rearrangement of oxime sulfonate, followed by addition of Grignard reagents starting from formula VI by the method set forth in (Tetrahedron Lett., 23, 3395, 1982). c) XV-a (R 1 is a group other than hydrogen) can be prepared by the nitrone rearrangement from V and N-alkyl, N-benzyl or N-phenyl hydroxy a ine according to the method analogous to that set forth in (J. Org. Chem. , 47, 3876, 1982; Tetrahedron, 44, 5209, 1988). d) Formula XlV-a can be prepared from formula Xlll-a in a similar manner to that described for the transformation of XI to XII shown in Scheme II. Scheme III a) Formula XVI can be prepared by hydrolysis of formula XIV with 48% HBr (at 20°C to refluxing temperature, preferably at refluxing temperature) , or a Lewis acid such as boron tribromide, aluminum trichloride, or trimethylsilyl iodide in an aprotic solvent such as methylene chloride or chloroform at a temperature between -78°C to 50°C, preferably at -40°C to 20°C. b) Compound I (R 14 =H) can be prepared by reacting a compound of formula XVI with R 13 N=C=0 or R 13 N=C=S in the presence of a catalytic amount of base such as sodium hydride, sodium, or sodium alkoxide in an aprotic solvent such as tetrahydrofuran, ether, benzene, toluene at 0°C to 50°c, preferably at 20°C. c) Compound I can also be prepared by treatment of XVI with l,l'-carbonyldiimidazole or l,l'-thiocarbonyldi- imidazole and R 13 R 14 NH in an aprotic solvent such as methylene chloride, tetrahydrofuran, or toluene at -40°C to 100°C, preferably at 20°C to 70 β C. In an alternative method compound I can be prepared by treatment of XVI with R 13 R 14 NCXC1 in the presence of base such as potassium carbonate or triethyl amine in an aprotic solvents such as dimethylformamide, methylene chloride, or tetrahydrofuran at temperature of from about 20°C to refluxing temperature. Scheme IV a) Optical resolution can be performed at any amine stage such as intermediate XIII, XIV or final compound I with chiral acids such as mandelic acid, tartaric acid, di-p-toluoyl-tartaric acid as shown in Scheme IV. b) The resolution can also performed by reacting XIII with a chiral alkyl isocyanate to form diastereomers, then separating the diastereomers by either recrystallization or chromatography, followed by hydrolysis to give each enantiomer. The optical resolution can also performed according to the methods analogous to those set forth in J. med. Chem. 29, 2268, 1986; Helv. Chim. Acta, 69, 283 and 1486, 1986. Other Compounds a) The methods described in Schemes I to IV are directed to the synthesis of compounds of the formula I wherein R 5 , R 6 and R 8 are each independently hydrogen, (C j to C 8 ) alkyl, phenyl, substituted phenyl, fluoro, amino, alkylamino, dialkylamino, (C j to C 4 )alkyl substituted with one to three fluorine atoms, or cyano group. b) Compounds of the invention wherein R 5 , R 6 , or R 8 is COOR 12 can be obtained using methods known in the art from these compounds wherein R 5 , R 6 , or R 8 is CN. c) Compounds of the invention wherein R 5 , R 6 , or R 8 is a halogen (Cl or Br) or nitro can be obtained by halogenation of the final compound (R 5 , R 6 , or R 8 are hydrogen) with N-chlorosuccinimide, or N-bromosuccinimide, or nitronium tetrafluorobor te. Compounds of Formula I are capable of forming acid addition salts with pharmaceutically acceptable acids. The acid addition salts may be prepared by reacting the base form of the appropriate compound of formula I with one or more equivalents, preferably with 1 equivalent, of the appropriate acid in an organic solvent, for example, diethyl ether, an ethanol/diethyl ether mixture, ethanol, methanol, or i-propanol. Suitable acids to form these salts include the common mineral acids, e.g. hydrohalic, sulfuric or phosphoric acid; the organic acids, e.g. ascorbic, citric, lactic, aspartic, p-toluenesulfonic acid; methanesulfonic acid; di-p-toluoyl-(D) or (L)tartaric acid; mandelic acid; fumaric acid; succinic acid; salicylic acid; oxalic acid or tartaric acid or their aqueous solutions whose pH has been adjusted to 5.5 or less; and acids which are sparingly soluble in body fluids and which impart slow-release properties to their respective salts, e.g. pamoic or tannic acid or carboxymethyl cellulose. Preferred salts are the hydrochloride salt, esylate salt, tartrate salt, or di-p-toluoyl-L-tartrate salt. The compounds of formula I and the pharmaceutically acceptable salts thereof are useful in the treatment of various memory dysfunctions associated with decreased cholinergic function such as Alzheimer's Disease. Additionally, the compounds lead to stimulation of neuromuscular transmission, enhancement of excitation in excitable tissues (nerve, and smooth and striated muscle) as well as restoration of conductance in nerves and neuromuscular synapses in the case of injury thereof. The compounds of this invention are, in general, less toxic and have a broader therapeutic window than known compounds such as tacrine and physotigmine, making them therapeutically preferred. In treating Alzheimer's disease, the dosage of the compounds of the present invention will vary with the form of administration and the particular compound chosen. Furthermore, it will vary with the particular subject as well as the age, weight and condition of the subject under treatment as well as with the nature and extent of the symptoms. Generally, however, a dose in the range of about 1 to about 300 mg/day, taken in single or divided doses, will be administered. The preferred dose is in the range of from about 1 to about 300 mg/day in single or divided doses. Generally, treatment is initiated with small dosages substantially less than the optimum dose of the compound. Thereafter, the dosage is increased by small increments until the optimum effect under the circumstances is reached. The compounds of the present invention are used alone or in combination with pharmacologically acceptable carriers, the proportion of which is determined by the solubility and chemical nature of the compound, chosen route of administration and standard medical practice. For example, they are administered orally in the form of capsules, tablets, suspensions or solutions or they may be injected parenterally. Capsules and tablets are the preferred mode of administration. For parenteral administration, they can be used in the form of a sterile solution containing other solutes, for example, enough saline or glucose to make the solution isotonic. Capsule and tablet compositions may contain the active ingredient in admixture with one or more pharmaceutical excipients suitable for the manufacture of capsules and tablets. Suitable pharmaceutical excipients are, for example, starch, milk sugar, and certain types of clay. The tablets can be uncoated or they can be coated by known techniques so as to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. Aqueous suspensions of the compounds of formula I contain the active ingredient in admixture with one or more pharmaceutical excipients suitable for the manufacture of aqueous suspensions. Suitable excipients are, for example, methylcellulose, sodium alginate, gum acacia, lecithin and so forth. Aqueous suspensions can also contain one or more preservatives, one or more coloring agents, one or more flavoring agents and one or more sweetening agents. Non-aqueous suspensions can be formulated by suspending the active ingredient in a vegetable oil for example, arachis oil, olive oil, sesame oil, or coconut oil, or in mineral oil, for example liquid paraffin, and the suspension may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. These compositions can also contain a sweetening agent, flavoring agent and antioxidant. The following examples illustrate the preparation and properties of the compounds of the present invention. All melting points are uncorrected. Thin layer chromatography (TLC) was conducted on silica gel. Preparations and Examples Preparation 1 5-Methoxy-3a-methyl-tetrahydro-l-indenof2.l-b]pyrrol-2- (lH.-one A. l-Methyl-6-Methoxy-l-indene A solution of 6-methoxy-l-indanone (8.1 g, 50 mmol) in dry THF (tetrahydrofuran) was added dropwise to a solution of methyl magnesium bromide (3N in ether, 20 ml, 60 mmol) in dry THF at 0°C. After completion of addition, the mixture was stirred at room temperature (~20°C) for 0.5 hour and quenched with aqueous HCl to pH 1 and extracted with ethyl acetate. The organic layer was washed with brine, dried, and concentrated to give 6.86 g of white crystals, mp 46-47°C; 'HMR (CDC1 3 ) δ 2.35 (s, 3H) , 3.25 (m, 2H) , 3.9 (s, 3H) , 6.25 (m, 1H) ; 6.75 (dd, 1H) , 6.9 (d, 1H) , 7.35 (d, 1H) ppm; 13 C NMR (CDC1 3 ) δ 13.0, 37.0, 55.6, 104.8, 110.3, 123.9, 130.2, 136.5, 139.8, 147.6, 158.95 ppm. B. l-Methyl-6.7-(9-methoxyibenzo-2.2-dichloroT3.2.01- hept- 3-one To a stirred mixture of l-methyl-6-methoxy-l- indene (2.632 g, 16.45 mmol) and activated Zinc (1.19 g, 18.23 mmol) in anhydrous ether was added a solution of C1 3 CC0C1 (1.0 ml, 17 mmol) and P0C1 3 (1.6 ml, 17 mmol) in ether. The mixture was refluxed for 2 hours, then stirred at room temperature overnight. Workup afforded a brown oil which can be used directly for the next dehalogenation step. 0.5 g material was purified through silica gel column purification to give white crystals, mp 65-67°C; *H NMR (CDC1 3 ) δ 1.8 (s, 3H) , 3.0-3.3 (m, 2H) , 3.8 (s, 3H) , 3.96 (dd, 1H) , 6.84 (m, 2H) , 7.1 (m, 1H) ppm, Anal. (Cι 3 Hj 2 0 2 Cl 2 ) C, H. C. l-Methyl-6,7-(9-methoxy)benzo 3 .2.01hept-3-one A solution of the crude material of the product of Preparation IB in methanol was treated with 8 g of Zinc and 6.4 g of NH 4 C1 and heated to 45-50°C overnight. The mixture was filtered through (diatomaceous earth (celite (trademark) ) and the filtrate was concentrated to give a white solid which was purified through silica gel chromatography to give 2.423 g of white crystals, mp 71-72°C; *H NMR (CDC1 3 ) δ 1.23 (s, 3H) , 2.95-3.35 (m, 4H) , 3.55-3.65 (m, 1H) , 3.8s, 3H) , 6.7-6.8 (m, 2H) , 7.05 (d, 1H) ppm; 13 C NMR (CDC1 3 ) δ 24.5, 32.5, 44.1, 55.5, 61.0, 68.7, 108.9, 113.7, 125.6, 134.2, 149.5, 160 ppm; Anal. (C 13 H 14 0 2 ) C, H, N. D. 1-Methyl-6.7-(9-methoxy) benzof3.2.01hept-3- hydroxyoxime A solution of the preparation of 1C (2.084 g, 10.3 mmol) in methanol was treated with NH 2 OH, HCl and sodium acetate and stirred at room temperature overnight. Purification through silica gel column afforded 1.581 g of the title compound as white crystals, mp 116-117°C; *H NMR (CDC1 3 ) δ 1.55 (S, 3H) , 2.9-3.3 (m, 4H) , 3.4-3.6 (m, 1H) , 3.78 (s, 3H) , 6.65-6.8 (m, 2H) , 7.05 (m, 1H) , 8.3 (brs, 1H) ppm; 13 C NMR (CDC1 3 ) δ 24.3, 35.1, 44.7, 48.0, 54.1, 55.5, 108.5, 113.5, 125.7, 184.6, 150.0, 159.5, 160.2 ppm, Anal. E. 5-Methoxy-3a-methyl-tetrahydro-l-indenor2,1-b]- pyrrol-2 ( IE)-one A solution of the title compound of ID Preparation (434 mg) in CH 2 C1 2 was treated with NaH (88 mg) at 0°C. After 5 minutes, the mixture was treated with tosyl chloride (419 mg) and stirred at 0 β C for 8 hours and then at room temperature overnight. The mixture was quenched with 2N NaOH, extracted with CH 2 C1 2 , dried and concentrated to dryness. The residue was triturated with ether to give 260 mg of a white solid. X H NMR (CDC1 3 ) δ 1.38 (s, 3H) , 2.58 (ABq, 2H) , 2.78 (d, IH) , 3.16 (dd, IH) , 3.77 (s, 3H) 4.03 (d, IH) , 6.51 (S, IH, NH) , 6.69 (s, IH) , 6.74 (d, IH) , 7.06 (d, IH) ppm. Preparation 2 A. 3 . 3a . 8 . 8a , -Tetrahydro-indeno r 2 . l-bl pyrrol-2- (lH) -one A. Methyl 5-methoxy-l-indanone-3-acetate A solution of 5-methoxy-l-indanone-3-acetic acid (30.0 g, 0.136 mmol) in methanol (200 ml) was treated with concentrated H 2 S0 4 (4 ml) and heated under reflux for 3 hours and then stirred at room temperature overnight. The resulting solution was concentrated to dryness. The residue was neutralized with saturated NaHC0 3 and extracted with ether. The organic layer was washed with water, dried and concentrated to give the title compound as a yellow solid (29.5 g) . *H NMR (DMSO-d δ 2.48 (s, 2H) , 3.18 (m, 2H) , 3.46 (s, 3H) , 3.86 (s, 3H) , 4.24 (t, IH) , 7.0 (dd, J=l and 7 Hz, IH) , 7.14 (d, J=l Hz, IH) , 7.64 (d, J=l and 7 Hz, IH) ppm. B. 5~Methoxy-3-methoxycarbonylmethyl-l-indanone-2- hydroxyoxime A solution of the title compound of Preparation 2A (29.15 g, 0.1244 mol) in anhydrous ether (200 ml) was saturated with HCl gas and cooled to 5-10°C in an ice bath and butyl nitrite was added dropwise and stirred for 3 hours. The product was filtered off to yield the title compound as an orange solid (28.8 g) . *H NMR (DMSO-dg) δ 2.46 (m, 2H) , 3.16 (m, 2H) , 3.42 (s, 3H) , 3.82 (s, 3H) , 4.2 (t, J=4Hz, IH) , 6.96 (dd, J=l and 7 Hz, IH) , 7.12 (d, J=lHz, IH) , 7.64 (d, J=7Hz, IH) ppm. C. 3a.8a-Dihydroindenor2.1-blPyrrol-2.8-(lH, 3H)-dione A solution of the title compound of Preparation 2B (1.0 g, 3.8 mmol) in acetic acid (50 ml) saturated with HCl gas was treated with 10% Pd on charcoal (0.5 g) and hydrogenated at 50 psi for 1 hour. After removal of the catalyst, the filtrate was heated to reflux for 4 hours, and the reaction was monitored by thin layer chromatography (5% methanol in CHC1 3 ) . Removal of solvents gave a brown solid. The solid was trituated with ether to give the title compound as a yellow solid (0.59 g) . J H NMR (DMSO=d < ;) δ 2.24 (dd, J=2 and 18Hz, IH) , 2.84 (dd, J=8 and 18Hz, IH) , 3.9 (s, 3H) , 4.04 (m, lh) , 4.2 (d, J=4Hz, IH) , 7.04 (dd, J=l and 7Hz, IH) , 7.18 (d, J=1HZ, IH) , 7.62 (d, J=7Hz, IH) , 8.58 (s, IH, NH) ppm. D. 3 r 3a.8.8a-Tetrahydro-indenor2.l-b]pyrrol-2-(IH)- one A solution of the title compound of Preparation 2°C (10 g, 0.046 mol) and 10% Pd in charcoal (5 g) in acetic acid (150 ml) was hydrogenated at 50 psi at 70°C for 4 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness to give a solid which was trituated with ether to give the title compound as a white solid (9.0 g) . l H NMR (DMSO-d δ 2.22 (d, J=14Hz, IH) , 2.64 (dd, J=10 and 14Hz, IH) , 2.72 (d, J=18Hz, IH) , 2.98 (dd, J=6 and 18Hz, IH) , 3.68 (S, 3H) , 3.70 (m, IH) , 4.3 (t, J=6Hz, IH) , 6.72 (dd, J=2 and 8Hz, IH) , 6.8 (d, J=2Hz, IH) , 7.08 (d, J=8Hz, IH) ppm. Preparation 3 3.3a.8.8a-Tetrahydro-3a-methyl-indenor2. l-b]pyrrol- 2(i -one Following the methods of Preparations 2A, 2B, 2C and 2D, the title compounds of Preparations 3A, 3B, 3C and 3D, respectively, were prepared. A. Methyl 5-methoxy-l-indanone-3-methyl-3 -acetate ] H NMR (CDC1 3 ) δ 1.4 (s , 3H) , 2.52 (d, J=18z , IH) , 2.68 (ABq, AB =H HZ , 2H) , 2.97 (d, J=18 Hz , IH) , 3.56 (s, 3H) , 3 .83 (S , 3H) , 6.8-6.9 (m, 2H) , 7.6 (d, J=6 Hz , IH) ppm. B. 5-Methoxy-3-methyl-3-methoxycarbonylmethyl-l- indanone-2-hydroxyoxime α H NMR (CDC1 3 ) δ 1.64 (s, 3H) , 2.94 (d, J=17Hz , IH) , 3 .4 (S , 3H) , 3.87 (d, J=16HZ , IH) , 3.9 (s, 3H) , 6.84 (d, J=2Hz , IH) , 6.92 (dd, J=2 and 8Hz , IH) , 7.82 (d, J=8Hz , IH) ppm. C. 3a.8a-Dihydro-3a-methyl-indenor2.l-blpyrrol-2.8- flH.3H)-dione *H NMR (CDC1 3 ) δ 1.61 (s, 3H) , 2.60 (d, 2H) , 3.82 (s, IH) , 3.90 (s, 3H) , 6.40 (s, IH, NH) , 6.87 (d, J=2Hz, IH) , 6.95 (dd, J=2 and 8Hz, IH) , 7.68 (d, J=8Hz, IH) ppm. D. 3 . 3a . 8 , 8a-Tetrahydro-3a-methyl-indeno r 2 , 1-b l - pyrrol-2 (lHΪ -one (4b) Recrystallization from i-PrOH gave a white crystals , mp 197-198 °C. *H NMR (CDCl 3 ) δ 1.38 (s, 3H) , 2.58 (ABq, J AB =7Hz , 2H) , 2.78 (d, J=18Hz , IH) , 3.16 (dd, J=6 and 17Hz , IH) , 3 .77 (s , 3H) , 4.03 (d, J=6HZ , IH) , 6.51 (s, IH, NH) , 6. 69 (s , IH) , 6.74 (d, J=8Hz , IH) , 7.06 (d, J=8Hz , IH) ppm. Example 1 5-Methoxy-l.2.3.3a.8.8a-Hexahydro-indeno[2.1-b]pyrrole To a suspension of LiAlH 4 (0.14 g, 3.69 mmol) in dry THF (10 ml) was added a solution of the title compound of Preparation 2D in THF (3 ml) dropwise. When the addition was complete, the mixture was heated to reflux for 5 hours. The mixture was cooled and treated by successive dropwise addition of H 2 0 (0.14 ml), 15% NaOH solution (0.42 ml), and H 2 0 (0.42 ml) . The mixture was stirred for 20 minutes and granular precipitates was filtered off. The filtrate was dried and concentrated to yield the title compound as an oil 1.6 g. *H NMR (CDC1 3 ) δ 1.9 (m, IH) , 2.2 (m, IH) , 2.82 (d, J=15 Hz , IH) , 2 .84 (m, 2H) , 3 .2 (dd, J=6 and 15 Hz , IH) , 3 .7 (m, IH) , 3 . 98 (S , 3H) , 4. 0 (t, J=6Hz , IH) , 6. 7 (m, 3H) , 7. 04 (d, J=7HZ , IH) ppm. Example 2 Resolution of racemic 5-methoxy-1.2.3.3a.8.8a-hexa- hydro-indenof2.1-blpyrrole To a solution of racemic l,2,3,3a,8,8a-hexahydro- 5-methoxy-indeno[2,1-b]pyrrole (1.2 g, 6.34 mmol) in 2-propanol (5 ml) was added a solution of (S)-madelic acid (0.96 g, 6.34 mmol) at room temperature and stirred for 1 hour. White precipitate formed and was filtered. The white solid was collected and washed with 2-propanol. The solid was basified to pH 13 and extracted with CH 2 C1 2 . The organic layer was dried and concentrated to give 0.32 g of oil ([-] D = -76.00°). The oil was converted to (S)-madelic acid salt again, recrystallized, and basified to give 0.191 g of oil ([α] D = -80.2°). The filtrate was basified to give an oil, which was converted to (R)-madelic acid salt, recrystallized from 2-propanol, basified to give 0.24 g of oil ([α] D = +74.5°). This process was repeated several times to give 0.13 g of oil ([α] D = 80.0°) . Both enantiomers were converted to the corresponding Nj-carbamate diasteroisomers by reaction with 1 eq. (S)-l-(phenyl)ethyl isocyanate in CH 2 C1 2 and evaporated to dryness. The optical purity was determined by *H NMR (CDC1 3 ) . The methyl peak of the (-) isomer and (+) iso er showed at 1.45 ppm and 1.49 ppm, respectively. Example 3 5-methoxy-3a-methyl-l,2.3 r 3a,8,8a-hexahydro-indeno- f2,1-b]pyrrole Following the method of Example 2, the title compound was prepared. *H NMR (CDC1 3 ) δ 1.3 (s, 3H) , 1.8-2.15 ( , 2H) , 2.6 (s, IH, NH) , 2.7-2.95 (m, 2H) , 3.0 (m, IH) , 3.24 (dd, J=6 and 18Hz, IH) , 3.58 (dd, J=2 and 6Hz, IH) , 3.8 (s, 3H) , 6.6-6.8 (m, 2H) , 7.06 (d, J=7Hz, IH) ppm. Example 4 Resolution of racemic 5-methoxy-3a-methyl-1.2.3,3a.8.- 8a-hexahydro-indenor2.1-b]pyrrole The racemic form of the title compound was resolved with di-p-tolouyl-L-tartaric acid by recrystallizing the salts several times as described in Example 3, and basified to afforded both pure optically active enantiomers as an oil with [α] D = -97.3°, respectively. Example 5 N-Alkylation of 5-Methoxy-l,2.3,3a.8,8a-hexahydro- indenor2,1-b1 yrrole A solution of 5-methoxy-l,2,3,3 ,8,8a-hexahydro- indeno[2,1-b]pyrrole in CH 2 C1 2 was treated with l.i equivalents of alkanoyl chloride and (e.g., acetyl chloride, propionyl chloride and 1.1 equivalents of pyridine and stirred at room temperature for 1 hour. The mixture was washed with H 2 0, extracted with CH 2 C1 2 . The organic layer was washed with dilute HCl, then neutralized with saturated NaHC0 3 , dried and concentrated to give the corresponding amide. To a solution of the amide in dry THF was added 3 equivalents of BH 3 .DMS dropwise. After addition, the mixture was heated at reflux for 3 hours and cooled to 0°C and methanol was added. The resulting solution was treated with concentrated HCl and stirred at room temperature overnight. Solvent was evaporated and the residue was washed with saturated 2 C0 3 and H 2 0, and extracted with CHC1 3 . The organic layer was dried and concentrated to yield 1-alkylated product. Following this procedure, the following compounds were prepared: A. (+/-)-!,2.3,3a.8.8a-hexahvdro-5-methoxy-l-ethyl- indenoT2,1-b1pyrrole: X H NMR (CDC1 3 ) δ 1.12 (t, 3H) , 1.7-1.9 (m, IH) , 2.1-2.4 (m, 3H) , 2.76-3.0 (m, 3H) , 3.0-3.2 (m, 2H) , 3.6-3.75 (m, IH) , 3.78 (d, 3H) , 6.7 (m, 2H) , 7.03 (m, IH) ppm. B. (+/-)-1.2.3.3a.8,8a-Hexahvdro-5-methoxy-l-propyl- indenof2,1-blpyrrole: 'H NMR (CDC1 3 ) δ 0. 92 (t , 3H) , 1. 4-1. 9 (m, 4H) , 2 . 15-2 . 4 (m, 2H) , 2 . 6-3 . 3 (M, 5H) , 3 . 5-3 . 8 (m, 4H) , 6. 7 (m, 2H) , 7 . 05 (d , IH) ppm. C. (+/- )-1.2.3.3a.8.8a-Hexahvdro-5-methoxy-l-ethyl- 3a-methyl-indenor2.1-b]pyrrole: *H NMR (CDC1 3 ) δ 1.15 (t, 3H) , 1.35 (s, 3H) , 1.86-2.1 ( , 2H) , 2.2-2.4 (m, 2H) , 2.62-2.92 (m, 3H) , 2.92-3.12 (m, 2H) , 3.76 (s, 3H) , 6.65 (d, J=2Hz, IH) , 6.68 (d, J=2Hz, 2H) , 7.0 (d, J=7Hz, IH) ppm. D. (-)-1.2.3.3a.8,8a-Hexahydro-5-methoxy-l-ethyl-3a- methyl-indenor2.1-b]pyrrole: [α] D » -110.7°. E. ( + / - ) -1.2.3.3a.8.8a-Hexahvdro-5-methoxy-l-n- propyl- 3a-methyl-indenor2.1-blpyrrole: *H NMR (CDC1 3 ) δ 0.9 (t, 3H) , 1.3 (s, 3H) , 1.4-1.6 (m, 2H) , 1.8-2.4 (m, 4H) , 2.6-3.1 (m, 5H) , 3.76 (s, 3H) , 6.66 (m, 2H) , 7.02 (d, IH) ppm. Example 6 ( + /-) -! .2 .3.3a.8.8a-Hexahvdro-5-methoxy-l-ethyl-3a- methyl-indeno[2.l-bl yrrole: A solution of the title compound of Example 3 (0.7 f) in acetic anhydride (25 ml) was heated at reflux for 1 hour and concentrated to dryness. The residue was neutralized with saturated NaHC0 3 and extracted with ethyl acetate to give a tan solid (0.78 g) . The solid was dissolved in dry THF (25 ml) and treated with 2M BH 3 .DMS in THF (4 ml, 8 mmol) at 0°C. The resulting solution was heated at reflux for 3 hours, then cooled to 0°C and methanol (10 ml) was added dropwise. The solvent was evaporated and 2N HCl (25 ml) was added and the mixture was heated at reflux for 3 hours and cooled to room temperature, neutralized with saturated K 2 C0 3 and extracted with ethyl acetate, dried and concentrated to give the title compound as a colorless oil (0.73 g) . l E NMR (CDC1 3 ) δ 1.15 (t, 3H) , 1.35 (s, 3H) , 1.86-2.1 (m, 2H) , 2.2-2.4 (m, 2H) , 2.62-2.92 (m, 3H) , 2.92-3.12 (m, 2H) , 3.76 (s , 3H) , 6. 65 (d, J=2Hz , IH) , 6. 68 (d, J=2Hz , 2H) , 7 . 0 (d, J=7HZ , IH) ppm. Example 7 1.2.3.3a.8,8a-Hexahydro-5-methoxy-l-methyl-indeno- A solution of 5-methoxy-l,2,3,3a,8,8a-hexahydro- indeno[2,l-b]pyrrole (0.4 g, 2.11 mmol) in ethanol (30 ml) was treated with 37% formaldehyde in H 2 0 (0.35 ml) and 10% Pd in charcoal (0.2 g) and hydrogenated at 50 psi for 2.5 hours. The catalyst was removed by filtration through diatomaceous earth Celite (trademark) and the filtrate was concentrated and dried in vacuo to give the title compound as a solid (0.38 g) . l K NMR (CDC1 3 ) δ 1.8-1.95 (m, IH) , 2.24-2.4 (m, 5H) , 2.8-3.06 (m, 4H) , 3.6-3.8 (m, 4H) , 6.66 (m, 2H) , 7.02 (m, IH) ppm. Example 8 1.2.3.3a.8.8a-Hexahydro-5-methoxy-l.3a-dimethyl-indeno- r2.1-b1pyrrole Following the method of Example 7, the title compound was prepared. X H NMR (CDC1 3 ) δ 1.3 (s, 3H) , 1.9-2.15 (m, 2H) , 2.36, (S, 3H) , 2.35-2.5 (m, IH) , 2.5-2.7 (m, IH) , 2.7-3.05 (m, 3H) , 3.75 (s, 3H) , 4.7-4.9 (m, IH) , 6.6-6.7 (m, 2H) , 7.0 (m, IH) ppm. Example 9 Preparation of Hexahvdro-indenor2,1-b]pyrrole carbamates A solution of 5-methoxy-l-alkyl-l,2,3,3a,8,8a- hexahydroindeno[2,1-b]pyrrole in 48% HBr (7 ml/mmol) was heated at reflux for 4 hours and evaporated to dryness. The residue was dissolved in methanol and treated with 1 equivalent of sodium methoxide and stirred for 30 minutes. After removal of solvent, the residue was treated with a minimum amount of isopropanol (5 ml) and filtered to remove inorganic material. The filtrate was concentrated to dryness. The residue was treated three times with benzene and evaporated to dryness to give the corresponding 5-hydroxy compound. A solution of the 5-hydroxy derivative (e.g. (+/-)-1,2,3,3a,8,8a-hexahydro-l-ethyl-3a-methyl- indeno[2,l,b]pyrrol-5-ol in dry ether (or THF or benzene) was treated with 0.1 equivalent of NaOH and stirred for 30 minutes and added 1.1 equivalent or alkylisocynate at room temperature and stirred for 2 hours. The mixture was quenched with H 2 0 and extracted with CHCI^ to give the desired 5-carbamate which was purified through silica gel column chromatography. Following this procedure, the following compounds were prepared. A. ( + /-)-1.2 r 3.3a.8,8a-Hexahydro-l-ethyl-3a-methyl- indenor2.1-b]pyrrol-5-ol, heptyl carbamate ester: (Oil) *H NMR (CDC1 3 ) δ 0.84 (m, 3H) , 1.4-1.6 (m, 2H) , 1.9-2.1 (2H) , 2.3-2.5 (m, 2H) , 2.78-3.16 (m, 5H) , 3.2 (q, 2H) , 5.0 (t, IH, NH) , 6.8-6.9 (m, 2H) , 7.06 (d, IH) ppm. B. (-)-1.2.3.3a.8„8a-Hexahvdro-l-ethyl-3a-methyl- indenof2.1-b] yrrol 5-ol. heptyl carbamate ester: Anal. (C^H^NjOjj.di-p-toluoyl-L-tartaric acid) calc. c, 67.72; H, 7.04; N, 3.76. Found: C, 67.77, H, 7.22; N, 4.00. [α] D = -75.69°, mp 89-92°C. C. (+) -! .2.3.3a.8.8a-Hexahydro-l-ethyl-3a-methyl- indenof2.1-b]pyrrol-5-ol. n-heptyl carbamate ester: Anal , calc : (C 22 H 34 N 2 O 2 . C 20 Hι 8 O 8 ) C, 67.72 ; H, 7.04 ; N, 3 . 76. Found: C, 67 . 14 ; H, 6. 96 ; N, 3 .82 . D« (+/-- -1-2.3.3a.8.8a-Hexahydro-l-ethyl-3a-methyl- indeno[2.1-b1pyrrol-5-ol. n-hexyl carbamate ester: (Oil) ! H NMR (CDC1 3 ) δ 0.86 (m, 3H) , 1.08 (t, 3H) , 1.2-1.4 (m, 9H) , 1.4-1.6 (m, 2H) , 1.85-2.15 (m, 2H) , 2.2-2.4 (m, 2H) , 2.7-3.16 (m, 5H) , 3.2 (q, 2H) , 5.1 (t, IH, NH) , 6.8-7.0 (m, 2H) , 7.08 (d, IH) ppm. E. f -i -1 . 2 . 3 r 3a . 8 . 8a-Hexahydro-l-ethyl-3a-methyl- indenor2 . 1-b]pyrrol-5-ol . n-heχyl carbamate ester (from ( - ) -1 . 2 . 3 . 3 a . 8 , 8a-hexahvdro-l-ethyl-3a-methyl-indeno- T 2 . l . blPyrrol-5-ol and n-hexyl isocyanate and sodium hydride) : [o] D = -73 . 54 ° . F. (+)-1.2.3.3a.8.8a-Hexahvdro-l-ethyl-3a-methyl- indenor2.1-b]pyrrol-5-ol. n-hexyl carbamate ester: [GI D = +78.5°, the corresponding di-p-toluoyl-L-tartaric acid salt, mp 122-123. G. (+/-)-1,2.3.3a τ 8.8a-Hexahydro-l-ethyl-3a-methyl- indenor2.1-b1pyrrol-5-ol. n-butyl carbamate ester: (Oil) *H NMR (CDC1 3 ) δ 0.90 (t, 3H) , 1.01 (t, 3H) , 1.28 (s, 3H) , 1.2-1.6 (m, 4H) , 1.8-2.1 (m, 2H) , 2.1-2.3 (m, 2H) , 2.6-2.9 (m, 3H) , 12.9-3.1 (m, 2H) , 3.19 (q, 2H) , 5.08 (t, IH, NH) , 6.7-6.9 (m, 2H) , 7.0 (d, IH) ppm. H. ( + /-) -! .2.3.3a.8.8a-Hexahydro-l-ethyl-3a-methyl- indeno 2.l-blpyrrol-5-ol. t-butyl carbamate ester: (White crystals) X H NMR (CDC1 3 ) δ 1.07 (t, 3H) , 1.28 (s, 3H) , 1.32 (S, 9H) , 1.8-2.1 (m, 2H) , 2.2-2.4 (m, 2H) , 2.7-3.1 (m, 5H) , 4.88 brs, IH) , 6.8-6.9 (m, 2H) , 7.04 (d, IH) ppm. The tosylate salt: *H NMR (DMS 2 0) δ 1.3-1.5 (m, 12H) , 1.44 (S, 3H) , 2.3-2.4 (m, 2H) , 2.38 (s, 3H) , 3.1-3.35 (m, 2H) , 3.4-3.6 (m, 3H) , 3.91 (d, IH) , 6.97 (m, IH) , 7.03 (s, IH) , 7.27 (d, IH) , 7.36 (d, 2H) , 7.64 (d, 2H) ppm. I. (+/-)-1.2.3.3a.8.8a-Hexahydro-l-ethyl-3a-methyl- indeno[2.l-b]pyrrol-5-ol, n-propyl carbamate ester: (Oil) X H NMR (CDC1 3 ) δ 0.94 (t, 3H) , 1.14 (t, 3H) , 1.32 (S, 3H) , 1.5-1.7 (m, 2H) , 1.9-2.2 (m, 2H) , 2.3-2.5 (m, 2H) , 2.7-3.2 (m, 5H) , 3.2 (q, 2H) , 5.0 (brs, IH) , 6.8-6.9 (m, 2H) , 7.09 (d, IH) ppm. J. (+/-)-!.2.3.3a,8,8a-Hexahydro-l-ethyl-3a-methyl- indenor2,l-blPyrrol-5-ol, methyl carbamate ester: (White crystals) *H NMR (CDC1 3 ) δ 1.11 (t, 3H) , 1.3 (s, 3H) , 1.9-2.1 (m, 2H) , 2.2-2.4 (m, 2H) , 2.7-3.1 (m, 8H) , 4.9 (brs, IH) , 6.8-6.9 (m, 2H) , 7.08 (d, IH) ppm. K. (+/-)-1,2,3,3a f 8.8a-Hexahydro-l-ethyl-3a-methyl- indenor2,l-blpyrrol-5-ol, phenyl carbamate ester: 'HNMR (CDC1 3 ) δ 1.22 (t, 3H) , 1.42 (s, 3H) , 2.0-1.5 (m, 4H) , 2.8-3.3 (m, 5H) , 7.0-7.3 (m, 4H) , 7.4-7.6 (m, 4H) ppm. L. ( + /-)-1.2.3.3a r 8,8a-Hexahydro-l-ethyl-3a-methyl- indenof2.l-blpyrrol-5-ol, benzyl carbamate ester: -31- J H NMR (CDCI 3 ) δ 1.2 (t, 3H) , 1.4 (s, 3H) , 1.9-2.2 (m, 2H) , 2.3-2.5 (m, 2H) , 2.8-3.2 (m, 5H) , 4.45 (d, 2H) , 5.48 (t, IH, NH) , 6.9 (m, 2H), 7.15 (d, IH) , 7.3-7.5 (m, 5H) ppm. M. (+/-)-1.2.3.3a.8.8 -Hexahvdro-l-ethyl-3a-methyl- indenor2.1-blpyrrol-5-ol. (S)-α-methylbenzyl carbamate ester: *H NMR (CDC1 3 ) δ 1.12 (t, 3H) , 1.3 (s, 3H) , 1.56 (d, 3H) , 1.8-2.1 (m, 2H), 2.2-2.4 (l, 2H) , 2.7-3.1 (m, 5H) , 4.9 (q, IH) , 5.245 (brs, IH) , 6.9 (m, 2H) , 7.05 (d, IH) , 7.24-7.4 (m, 5H)) ppm. N. ( + /-)-l f 2 ,3,3a,8.8a-Hexahvdro-l-ethyl-3a-methyl- indenor2,l-b pyrrol-5-ol, n-heptyl carbamate ester tosylate salt: (Oil) X H NMR (CDC1 3 ) δ 0.85 (t, 3H) , 1.2-1.4 (m, 8H) , 1.38 (S, 3H) , 1.4-1.6 (m, 2H) , 2.1-2.2 (m, 2H) , 2.3 (S, 3H) , 7.0-7.1 (m, 3H) , 7.54 (d, 2H) ppm. 0. (+/-) -1.2.3.3a .8.8a-Hexahydro-l .3a-dimethyl- indenof2.1-bl yrrol-5-ol. n-hexyl carbamate ester: *H NMR (CDCI 3 ) δ 0.86 (m, 3H) , 1.1-1.6 (m, 11H) , 1.8-2.6 (m, 6H) , 2.7-3.3 (m, 6H) , 5.1 (t, IH, NH) , 6.8-6.9 (m, 2H) , 7.05 (d, IH) , ppm. •P- ( + /-) -1 , 2.3.3a.8.8a-Hexahydro-l-n-propyl-3a- indenor2.1-b1pyrrol-5-ol. n-heptyl carbamate ester: J H NMR (CDC1 3 ) δ 0.8-1.0 (m, 6H) , 1.0-1.6 (m, 15H) , 1.8-2.4 (m, 4H) , 2.5-3.3 (m, 7H) , 5.18 (t, IH, NH) , 6.8 (m, 2H) , 7.04 (d, IH) ppm. Q ' (+/-)-!.2.3 f 3a.8,8a-Hexahydro-l-n-propyl-3a- methyl-indenor2.1-b]pyrrol-5-ol. n-hexyl carbamate ester: Η NMR (CDC1 3 ) δ 0.8 (m, 6H) , 1.1-1.6 (m, 13H) , 1.8-2.5 (m, 4H) , 2.5-3.2 (m, 7H) , 5.05 (t, IH, NH) , 6.7-6.8 (m, 2H) , 7.0 (d, IH) , ppm. R. ( + /-)-!.2.3.3a,8, 8a-Hexahydro-l-benzyl-3a- methyl-indenor2.1-blpyrrol-5-ol, methyl carbamate ester: (White crystals): ] H NMR (CDC1 3 ) δ 1.31 (s, 3H) , 1.8-2.0 (m, 2H) , 2.3-2.4 (m, IH) , 2.7-3.0 (m, 5H) , 3.25-3.4 (m, 3H) , 3.95 (d, IH) , 6.8 (m, 2H) , 7.14 (d, IH) , 7.2-7.3 (m, 5H) , 8.4 (brs, IH) ppm. S. (+/-)-!.2, 3, 3a.8, 8a-Hexahvdro-l-benzyl-3a- methyl-indenor2 ,l-b]pyrrol-5-ol f n-hexyl carbamate ester: *H NMR (CDC1 3 ) δ 0.86 (t, 3H) , 1.1-1.6 (m, 13H) , 1.8-2.05 (m, IH) , 2.2-2.49 (m, IH) , 2.7-3.5 (m, 6H) , 3.9 (d, 2H) , 4.99 (t, IH) , 5.3 (t, IH) , 6.8-7.1 (m, 3H) , 7.1-7.3 (m, 5H) ppm. T. (+/-) -1,2.3.3a.8 ,8a-Hexahydro-l-propyl-indeno- [2 ,l-b]pyrrol-5-ol. n-heptyl carbamate ester: (White crystals) H NMR (CDC1 3 ) δ 0.8-1.0 (m, 6H) , 1.2-1.4 (m, 8H) , 1.44-1.7 (m, 5H) , 1.8-1.96 (m, IH) , 2.2-2.5 (m, 3H) , 2.66-2.8 (m, IH) , 3.0-3.4 (m, 5H) , 3.7-3.8 (m, IH) , 4.9-5.0 (m, IH) , 6.8-6.96 (m, 2H) , 7.1 (d, IH) ppm. C^H^N^ Calc: C, 73.70; H, 9.56; N, 9.82. Found: C, 73.38; H, 9.69; N, 8.07. U. (+/-) -1.2.3.3a .8.8a-Hexahydro-l-propyl-indeno- [2,l-b]pyrrol-5-ol. n-hexyl carbamate ester: (White crystals) 'H NMR (CDC1 3 ) δ 0.8-1.0 (m, 6H) , 1.2-1.4 (m, 6H) , 1.4-1.6 (m, 4H) , 1.7-1.9 (m, IH) , 2.15-2.4 (m, 3H) , 2.6-2.8 (m, IH) , 2.8-3.3 (m, 6H) , 3.6-3.8 m, IH) , 4.9-5.0 (m, IH) , 6.8-6.95 (m, 2H) , 7.1 (d, IH) ppm. C^H^N^ Calc: C, 73.21; H, 9.36; N, 8.13. Found: C, 72.90; H, 9.80; N, 8.49. V. (+/-) -1.2.3.3a f 8 , 8a-Hexahydro-l-n-propyl-indeno- 2.1-blpyrrol-5-ol f n-hexyl carbamate ester: [α] D (CH 2 C1 2 ) = -130°. W. (+/-) -1.2.3.3a.8.8a-Hexahvdro-l-methyl-indeno- \2 ,l-b]pyrrol-5-ol. heptyl carbamate ester: (White crystals) *H NMR (CDC1 3 ) δ 0.88 (t, 3H) , 1.2-1.4 (m, 8H) , 1.46-1.6 (m, 2H) , 1.8-2.0 (m, IH) , 2.2-2.4 (m, 2H) , 2.38 (S, 3H) , 2.8-3.04 (m, 4H) , 3.16-3.3 (m, 2H) , 3.64-3.8 (m, IH) , 4.9-5.0 (m, IH) , 6.84 (d, IH) , 6.9 (s, IH) , 7.12 (d, IH) ppm. C 20 H 30 N 2 O 2 Calc: C, 72.69; H, 9.15; N, 8.48. Found: C, 72.45; H, 9.28; N. 8.53. X* (+/-) -! . 2 . 3 , 3a , 8 . 8a-Hexahydro-l-methyl-indeno- [2 . 1-b]pyrrol-5-ol , hexyl carbamate ester: (White crystals) *H NMR (CDC1 3 ) δ 0.8 (t, 3H) , 1.2-1.4 (m, 6H) , 1.45-1.6 (m, 2H) , 1.8-2.0 (m, IH) , 2.3-2.45 (m, 2H) , 2.4 (s , 3H) , 2.9-3.15 (m, 4H) , 3 .15-3.3 (m, 2H) , 3.65-3.8 (m, IH) , 6.85 (d, IH) , 6.9 (s, IH) , 7.1 (d, IH) ppm. Ci 9 H 28 N 2 0 2 Calc : C, 72.11 ; H, 8.92 ; N, 8.86. Found: C, 71.46 ; H, 8.79 ; N, 8.66. γ « ( + /-)-1.2.3.3a.8.8a-Hexahydro-l-ethyl-indeno- r2,l-b]pyrrol-5-ol, heptyl carbamate ester: (White crystals) X H NMR (CDC1 3 ) δ 0.8-0.9 (m, 3H) , 1.0-1.38 (m, 11H) , 1.4-1.6 (m, 3H) , 1.7-1.9 (m, IH) , 2.2-2.5 (m, 2H) , 2.8-3.4 (m, 7H) , 3.66-3.82 (m, IH) , 4.85-5.0 (m, IH) , 6.82 (d, IH) , 6.9 (s, IH) , 7.08 (d, IH) ppm. Z. (+/-)-!.2.3.3a.8.8a-Hexahydro-l-ethyl-indeno- r2,l-b]pyrrol-5-ol. propyl carbamate ester: (White crystals) l H NMR (CDC1 3 ) δ 0.8-1.0 (m, 3H) , 1.12 (t, 3H) , 1.26-1.9 (m, 4H) , 2.2-2.4 (m, 3H) , 2.75-3.3 ( , 6H) , 3.6-3.8 (m, IH) , 4.9 (brs, IH) , 6.82 (d, IH) , 6.9 (s, IH) , 7.08 (d, IH) ppm. AA. (+/-)-!.2.3 ,3a,8.8a-Hexahydro-l-ethyl-indeno- \2.l-blpyrrol-5-ol. butyl carbamate ester: (White crystals) X H NMR (CDC1 3 ) δ 0.8-1.0 (m, 3H) , 1.0-1.6(m, 8H) , 1.7-1.9 (m, IH) , 2.2-2.6 (m, 3H) , 2.75-3.4 (m, 6H) , 3.6-3.8 (m, IH) , 4.9 (brs, IH) , 6.82 (d, IH) , 6.88 (s, IH) , 7.07 (d, IH) ppm. AB. (+/-)-1.2.3,3a.8.8a-Hexahydro-l-ethyl-indeno- \ 2 ,l-blpyrrol-5-ol. hexyl carbamate ester: (White crystals) *H NMR (CDC1 3 ) δ 0.8-1.0 (m, 3H) , 1.1-1.6 (m, 11H) , 1.7-1.9 (m, IH) , 2.4-2.6 (m, 3H) , 2.75-3.3 (m, 7H) , 3.6-3.8 (m, IH) , 4.94 (brs, IH) , 6.82 (d, IH) , 6.90 (s, IH) , 7.08 (de, IH) ppm. The activity of the compounds of the present invention as cholinesterase inhibitors and analgesic agents may be determined by a number of standard biological or pharmacological tests. One such procedure for determining cholinesterase inhibition is described by Ellman et al. in "A New and Rapid Colorimetric Determination of Acetylchlinesterase Activity", Biochem. Pharm. 1, 88, (1961) . Examples of such procedures for determining analgesic activity are the hot plate assay described in Lab. Animal, 7, 42 (1978), and the tail-flick and phenylquinone assays described in J. Pharmacol. EXP. Ther.. 175, 435 (1970) and J. Pharmacol. EXP. Ther.. 179, 652 (1971). The title compounds of Example 9 were tested for AChE inhibition assay as described in the above procedure. All of the compounds were effective at a level of 1 μM to 10 μM or IC 50 . Human AChE (EC 3.1.1.7) purified from red blood cells and butyrylcholine iodide esterase (BuChE; EC 3.1.1.8) purified from serum were purchased from Sigma Chemical Company (St. Louis, MO) . Assays were performed as described by Ellman et al., (19061), using 200 μM acetylthiocholine iodide as substrate for AChE and 500 μM butyrylthiocholine iodide as substrate for BuChE. Kinetic parameters were calculated from enzyme inhibition curves fitted with non-linear least squares using the programs COMP, UCOMP and NCOMP (Cleland, 1979) .

Claims: CLAIMS 1. A compound of the formula wherein W is R 1 is hydrogen, (C-, to C 8 )alkyl, (C t to C 8 )cycloalkyl (C j to C 4 )alkyl, (C, to C 8 )alkenyl, phenyl, substituted phenyl, phenyl(Cj to C 4 )alkyl, substituted phenyl (C t to C 4 )alkyl or heteroaryl (C, to C 6 )alkyl wherein the heteroaryl groups are selected from pyridyl, thienyl or funanyl; R 3 and R 4 are independently hydrogen. (Ci to C 8 )alkyl, hydroxy, (Cj to C 8 )alkoxy, halogen (e.g., fluoro, chloro, bromo or iodo), amino, alkylamino or dialkylamino, wherein the groups on the alkyl and dialkylamino are independently (C x to C 6 )alkyl; R 5 , R 6 and R 8 are each independently hydrogen, (C j to C 8 )alkyl, phenyl, phenyl (Cj to C 8 )alkoxy, phenyl substituted with halogen, phenyl (Cj-C 4 )alkyl, halogen selected from the group consisting of fluoro, chloro, bromo or iodo, nitro, amino, alkylamino, dialkylamino, (Cj-C 4 )alkyl substituted with one to three fluoro groups, cyano, or COOR 12 wherein R 12 is C to C 12 )alkyl; R 7 is OH, SH, 0(Cj to C 4 )alkyl, S(C ! -C 4 )alkyl, OCONR 13 R 14 , SCONR 13 R 14 or OCSNR 13 R 14 , wherein R 13 and R 14 are independently hydrogen, (Cj to C 12 )alkyl, (C 3 to C 7 )cycloalkyl (C j to C 8 )alkyl, (C j to C 12 )alkenyl, phenyl, phenyl substituted with halogen, phenyl (Cj to C 8 )alkyl, substituted phenyl (Cj to C 8 )alkyl, heteroaryl, heteroaryl (Cj to C 8 )alkyl wherein said heteroaryl is selected from pyridyl, thienyl, furanyl, benzimidazolyl, thiazolyl, benzothiazolyl, or R 13 and R 14 taken together with the nitrogen to which they are attached forms a 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl; R 9 is hydrogen, (C x to C 8 )alkyl, (C t to C 8 )alkoxy, hydroxy; R 10 and R 11 are independently hydrogen, (Cj to C 6 )alkyl, phenyl, benzyl; and pharmaceutically acceptable acid addition salts thereof. 2. A compound according to claim l wherein R 10 , R 6 , R 8 , R 5 , and R 11 are hydrogen, R 1 is selected from the group consisting of hydrogen, Cj-C 4 alkyl, allyl and benzyl, W R 3 is —c wherein R 3 and R 4 are hydrogen and R 9 is hydrogen, -c 4 alkyl and R 7 is OCONR : ι 3 Rι wherein 3 13 are each independently hydrogen or alkyl, benzyl, phenyl, or the group -NR 13 R 14 taken as a whole is 1-pyrrolidinyl, 1-piperidiny1, 4-morpholinyl or 1-piperazinyl. 3. A compound according to claim 2 wherein R 9 is methyl, hydrogen and R 14 is (Cι-C 12 ) alkyl. 4. A compound according to claim 3 wherein R 14 is n-butyl, n-hexyl or n-heptyl and R 13 is hydrogen. 5. A compound according to claim 5 in the form of the (-) enantiomer. 6. A pharmaceutical composition for the treatment of memory dysfunctions characterized by decreased chollnergic functions comprising an effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier. 7. A compound of the formula: wherein R 1 is hydrogen, (C x to C 8 )alkyl, (C x to C 8 )cycloalkyl (C j to C 4 )alkyl, (Cj to C 8 )alkenyl, phenyl, substituted phenyl, phenyl (Cj-q,)alkyl, substituted phenyl ( to C 4 )alkyl or heteroaryl (Cj to C 6 )alkyl wherein the heteroaryl groups are selected from pyridyl, thienyl, and furanyl; R 3 and R 4 are each hydrogen; R 5 , R 6 and R 8 are each independently hydrogen, (Cj to C 8 )alkyl, phenyl, phenyl, substituted phenyl, phenyl(Cj to C 4 )alkyl, halogen (e.g., fluoro, chloro, bromo or iodo) , nitro, amino, alkylamino, dialkylamino, (C t to C 4 )alkyl substituted with one to three fluoro (e.g., trifluoromethyl) , cyano, or COOR 12 wherein R 12 is C j to C n alkyl; R 7 is 0^ to C 4 )alkyl, S(C X to C 4 )alkyl; R 9 is (C x - C 4 )alky, allyl, benzyl; R 10 and R n are independently hydrogen, (Cj to C 6 )alkyl, phenyl, benzyl; and pharmaceutically acceptable acid addition salts thereof, provided that when R 3 , R 4 , R 5 , R 6 , R 8 , R 10 and R 11 are hydrogen, R 1 and R 9 are not both methyl and R 7 is not 0CH 3 . 8. A compound of the formula: wherein R 1 is hydrogen, (C, to C 8 )alkyl, (q* to C 8 )cycloalkyl (Cj to C 4 )alkyl, (Cj to C 8 )alkenyl, phenyl, substituted phenyl, phenyl (C-.-C 4 )alkyl, substituted phenyl (C j to C 4 )alkyl or heteroaryl (Cj to C 6 )alkyl wherein the heteroaryl groups are selected from pyridyl, thienyl, and furanyl; R 3 and R 4 are each hydrogen; R 5 , R 6 and R 8 are each independently hydrogen, (C x to C 8 )alkyl, phenyl, phenyl, substituted phenyl, phenyl^ to C 4 )alkyl, halogen (e.g., fluoro, chloro, bromo or iodo) , nitro, amino, alkylamino, dialkylamino, (C { to C 4 )alkyl substituted with one to three fluoro (e.g., trifluoromethyl) , cyano, or COOR 12 wherein R 12 is C j to C 12 alkyl; R 9 is (Cj-Q)alkyl, allyl, benzyl; R 10 and R 11 are independently hydrogen, (C, to C 6 ) lkyl, phenyl, benzyl; Y is O or S; and pharmaceutically acceptable acid addition salts; or a prodrug of the formula YOH or YSH which is readily hydrolyzable in vivo to generate a YH group. 9. A pharmaceutical composition useful as an analgesic agent comprising a compound of claim 16 "or a prodrug form of the formula (YOH or YSH) which can be hydrolyzed readily in vivo to generate a YH group combined with a pharmaceutically acceptable carrier. 10. A process for the production of a compound of the formula wherein W is —c or C=0 V / R 1 is hydrogen, (C j to C 8 )alkyl, (C x to C 8 )cycloalkyl (C j to C 4 )alkyl, (Cj to C 8 )alkenyl, phenyl, substituted phenyl, phenyl(C j to C 4 )alkyl, substituted phenyl (C x to C 4 )alkyl or heteroaryl (Cj to C 6 )alkyl wherein the heteroaryl groups are selected from pyridyl, thienyl or funanyl; R 3 and R 4 are independently hydrogen. (C x to C 8 )alkyl, hydroxy, (C x to C 8 )alkoxy, halogen (e.g., fluoro, chloro, bromo or iodo), amino, alkylamino or dialkylamino, wherein the groups on the alkyl and dialkylamino are independently (Cj to C 6 )alkyl; R 5 , R 6 and R 8 are each independently hydrogen, (C t to C 8 )alkyl, phenyl, phenyl (Cj to C 8 )alkoxy, phenyl substituted with halogen, phenyl (Cι~C 4 )alkyl, halogen selected from the group consisting of fluoro, chloro, bromo or iodo, nitro, amino, alkylamino, dialkylamino, (Cj-C 4 )alkyl substituted with one to three fluoro groups, cyano, or COOR 12 wherein R 12 is (C x to C 12 )alkyl; R 7 is OH, SH, OfCj to C 4 )alkyl, Sf -q)alkyl, OCONR 13 R 14 , SCONR 13 R 14 or OCSNR 13 R 14 , wherein R 13 and R 14 are independently hydrogen, (C, to Cι 2 )alkyl, (C 3 to C 7 )cycloalkyl (Cj to C 8 )alkyl, (q to q 2 )alkenyl, phenyl, phenyl substituted with halogen, phenyl (q to C 8 )alkyl, substituted phenyl (q to C 8 )alkyl, heteroaryl, heteroaryl (q to C 8 )alkyl wherein said heteroaryl is selected from pyridyl, thienyl, furanyl, benzimidazolyl, thiazolyl, benzothiazolyl, or R 13 and R 14 taken together with the nitrogen to which they are attached forms a 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiomorpholinyl, 1-piperazinyl; R 9 is hydrogen, (q to C 8 )alkyl, (q to C 8 )alkoxy, hydroxy; ,10 and Ru are independently hydrogen, (C. to C 6 )alkyl, phenyl, benzyl; and pharmaceutically acceptable acid addition salts thereof, reducing a compound of the formula wherein R 1 , R 10 , R 9 , R 8 , R 6 , R 5 and W are as previously defined and R 19 is R 18 0 or R 18 S wherein R 18 is q-C 4 alkyl under appropriate conditions in a reaction inert solvent at a temperature of from about 20°C to about 100°C. 11. A process according to claim 1 wherein said reduction is carried out by using lithium aluminum hydride.

Inventors: CHEN YUHPYNG L, CHEN, YUHPYNG, L.
Applicants: PFIZER, PFIZER INC.
Application year: 1991
Main classification: A61K31
IPC codes: A61K31, A61P25, C07D209