Device for moving a cup holder within an analyzer

Abstract: A device is disclosed for translatorily moving a plate-shaped cup holder (12), equipped with cups (11) arranged successively in the direction of movement for receiving liquid, to the processing station (B) of an analyzer. The cups are used for mixing viscous body fluid, e. g. blood, with a diluent. Movement of the cup holder (12) and exact positioning of the cups (11) in the processing station (B) are effected in that the cup holder (12) frictionally rests on a driven endless belt (15), in that an incrementally driven indexing wheel (19) is brought into engagement with the cups (11), and in that a sensor means (27) is arranged in the vicinity of the indexing wheel (19), detecting the passage of each cup (11) and determining the indexing position of the indexing wheel (19) in which a cup (11) is located in its processing position (B).

Description: The present invention relates to a device for translatorily moving a plate-shaped cup holder, equipped with cups arranged successively in the direction of movement for receiving liquid, to the processing station of an analyzer. DE-PS 16 73 107 discloses an apparatus for analyzing liquids in which the sample tubes are moved by means of a chain drive within the analyzer. For this purpose, the individual chain links are provided with holding means into which the sample tubes can be inserted. The chain extends between two sprockets. The axle of one of the sprockets carries a disk having four recesses that are uniformly distributed over its periphery. In order to move a sample tube from a first processing station to a second, the disk rotates through 90 degrees and thereby carries along a sample tube engaged by a recess. The known apparatus is very complex, space-consuming and requires regular maintenance if it is to operate reliably. Further, US-A-4 403 687 and 4 727 033 disclose complex devices for handling cup holders in analizing apparatuses. It is the object of the present invention to provide a device of the generic type which is simply designed, operates reliably and guarantees exact positioning of the individual cups in a processing station. According to the invention, the above object is attained in that the cup holder frictionally rests on a driven continuous movement means, an incrementally driven indexing wheel is brought into direct engagement with the cups and in that a sensor means is arranged in the area of the indexing wheel, detecting the passage of a cup and determining the indexing position of the indexing wheel in which a cup is located in its processing position. Using simple means, the cups can thus be continuously fed to a processing station independent of the position of the continuous movement means. The exact alignment of the cups fed into the processing station is assured by means of the indexing wheel driven by a stepping motor in cooperation with the sensor means. In a preferred embodiment the indexing wheel is designed as a gear with the shape and size of its tooth spaces being dimensioned such that they can directly engage the appropriately formed cups. This enables a reliable translatory movement and exact positioning of the cup holders without using additional gear elements. Other features of the invention disclose that the central axis of the cup holder rests on the continuous movement means and that beneath and parallel thereto a housing bottom is provided at a distance slightly larger than the distance from the support surface of the cup holder to the lower end of a cup. Such configuration requires only a single continuous movement means since the cup bottoms are supported by the housing bottom and the cup holder is thus retained in a horizontal position. Further features and advantages will be apparent from the description of an embodiment shown in the drawing and from the sub-claims. Fig. 1 shows a schematic representation of the arrangement of the device according to the invention within an analyzer, Fig. 2 is a side elevation in cross-section of the device according to Fig. 1 (enlarged representation), Fig. 3 is a top view of the device according to Fig. 1, and Fig. 4 shows a top view of the cup holder according to Fig. 2. When examining body fluids, as for example blood serum, in an analyzer, it may happen that a liquid to be examined is too viscous and must be diluted in order to be able to obtain correct and usable results. For this purpose, cups 11 are provided in which the blood can be mixed with an appropriate diluent so as to obtain the required consistency. The present invention describes the feeding procedure of such cups to an analyzer and the alignment of same in a processing station. In the embodiment shown in the drawing the cups 11 are arranged in pairs side by side in a cup holder 12 which is integral with the cups 11 and consists of a chemically resistant plastic material. The device 10 is substantially comprised of an elongate housing 13 of U-shaped cross-section having a bottom 14, said housing being connected to a wall of the analyzer. Along the centerline of the elongate housing extends a continuous movement means designed as a belt 15 of circular cross-section which is tensioned and guided by several pulleys 16. An indexing wheel 19 rotated about a shaft 17 and driven by a stepping motor 18 is aligned with a processing station (not shown) and arranged such that in the area of a recess 22 its indexing teeth extend through the housing bottom 14 and project therefrom. The indexing wheel 19 is thereby located in the vertical plane of a row of the successively arranged cups 11. The indexing teeth 23 and the tooth spaces 25 are shaped such that they move directly into gear engagement with the cups 11 formed accordingly. The cup holder 12 virtually forms a rack cooperating with the indexing wheel 19. The distance between the support surface 26 of the cup holder 12 on belt 15 and the lower end portions of the cups 11 is slightly smaller than the spacing between the upper edge of belt 15 and the housing bottom 14. In this way, the cup holder is held in a horizontal position. The passage of cup 11 and the exact indexing position of indexing wheel 19 is detected by a sensor means 27 arranged in the area of the indexing wheel 19. For stabilizing the position of cup holder 12 when a cup 11 is located in the processing station, spring elements 28 are provided at the side walls of housing 13 which press the cup holder 12 onto a block 29 with belt 15 being located inbetween. In order to guarantee an unobstructed passage of the cup holders 12, the housing bottom 14 and the indexing wheel 19 are arranged such that the indexing teeth 23 which are not engaged with the cups 11 are positioned in or below the plane of housing bottom 14 when the indexing wheel 19 is in its indexing position. During a mixing or diluting procedure the analyzer operates as follows: The continuous movement means designed as a belt 15 is driven by a motor (not illustrated). A cup holder 12 inserted in the analyzer rests on belt 15 and is frictionally advanced until the sensor means 27 detects the passage of the first cup 11. Thereupon the stepping motor 18 is switched on and the indexing wheel 19 is rotated. The drive mechanism of belt 15 can now be turned off since one of the indexing teeth engages with the first cup 11 and advances it by one step corresponding to the pitch defined by the distance of two successive cups. Now the first pair of cups is positioned beneath a cover 30 protecting the cups from fouling by possible liquid splashes in the analyzer. If the drive mechanism of belt 15 continues to operate, further cup holders 12 can be placed on belt 15 and advanced until they abut the cup holder positioned in front of them. Due to a mere frictional engagement with the belt, the cup holders remain in their stand-by positions. If a blood sample needs to be diluted prior to analysis, this will be signalled and the cup holder 12 is advanced by the indexing wheel 19 until the first pair of cups is positioned in processing station. Aspirator 20 picks up a pipette 31 from a pipette tray 32 and collects a certain amount of blood from a sample tube (not illustrated) which is delivered into a cup 11. The used pipette 31 is discarded and a second one is picked up by the aspirator 20 from pipette tray 32. Now the aspirator 20 directs the fresh pipette 31 to a liquid container 33 whose lid 34 was previously automatically opened, aspirates a predetermined amount of liquid by means of a proboscis 21 and delivers it to cup 11 which is filled with blood and mixes it with the blood. As soon as blood and diluent have been mixed, the diluted blood mixture is re-aspirated and delivered to the analyzer for blood analysis. When this procedure is terminated, the stepping motor 18 is turned on again and the cup holder 12 is moved back by one step so that the still non-used cup 11 is again moved under the protective cover 30. If both cups 11 of a pair of cups have been used, the cup holder 12 remains in its position and, if required, the cup holder is advanced to its next clean pair of cups. When all cups 11 of a cup holder 12 are used up, the cup holder 12 is further advanced by belt 15 until it drops into a waste bin over the outermost pulley 16.

Claims: Device for translatorily moving a plate-shaped cup holder (12), equipped with cups (11) arranged successively in the direction of movement for receiving liquid, to the processing station of an analyzer and aligning it in said station, characterized in that the cup holder (12) frictionally rests on a driven continuous movement means (15), an incrementally driven indexing wheel (19) is brought into engagement with the cups (11), and a sensor means (27) is arranged in the area of the indexing wheel (19), detecting the passage of a cup and determining the indexing position of the indexing wheel in which a cup (11) is located in its processing position. Device according to claim 1, characterized in that the indexing wheel (19) is designed as a gear, and in that the shape and size of a tooth space (25) and those of the cup portion which is brought into engagement therewith are adapted to each other. Device according to claims 1 and 2, characterized in that the centerline of cup holder (12) rests on the continuous movement means (15), and in that beneath and parallel to said continuous movement means (15) a housing bottom (14) is provided at a distance slightly larger than the distance from the support surface (26) of cup holder (12) to the lower end of each cup (11). Device according to claims 1 thru 3, characterized in that the sensor means (27) detects the passage of a cup holder (12) by sensing the leading edge of a cup, and in that for aligning the indexing wheel (19) in a position in which a cup is present in processing position the sensor means (27) senses the leading edge of an indexing tooth (23). Device according to claims 1 thru 4, characterized in that in each of the indexing positions of the indexing wheel (19) the teeth (23) not yet engaged with the cup holder (12) are located in or below the plane of the housing bottom (14). Device according to claim 1, characterized in that the sensor means (27) is an optoelectric sensor. Device according to claim 1, characterized in that the continuous movement means is a belt (15) of circular cross-section. Device according to any of claims 1 thru 7, characterized in that the cup holder (12) and the cups (11) form an integral part. Device according to claim 8, characterized in that the cup holder (12) and the cups (11) form a molded plastic member. Device according to claims 1 thru 4 as well as 8 and 9, characterized in that a plurality of cups (11) are successively arranged in pairs in the direction of movement of the cup holder (12), in that after completion of the filling procedure of the first cup (11) of a pair of cups the cup holder (12) is retracted from processing position by one indexing step to take a position below a cover (30), and in that after completion of the filling procedure of the second cup of the pair of cups the cup holder (12) is advanced by one indexing step such that the following empty pair of cups is located in the processing position.

Inventors: HIRSCH ALEXANDER KODAK AKTIENG, HIRSCH, ALEXANDER, KODAK AKTIENGESELLSCHAFT
Applicants: EASTMAN KODAK CO, KODAK AG, CLINICAL DIAGNOSTIC SYSTEMS, INC.
Application year: 1991
Main classification: G01N35
IPC codes: G01N35, B65G47