HEXA- AND HEPTAPEPTIDE ANAPHYLATOXIN-RECEPTOR LIGANDS

Abstract: Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

Description: HEXA- AND H PTAPFPTTDF. ANAPHYT.ATOXTN-BFrFPTOP T.TGANDS TPrhniral Field This invention relates to organic compounds that modulate anaphylatoxin activity. It also relates to methods and compositions for modulating anaphylatoxin activity in human and animal hosts in need of such treatment. BaffTcprramri of 1-h-g Tπvpntiion A wide variety of conditions including infection by bacteria, viruses or fungi, infiltration by cancer cells, allergic or autoimmune disorders and physically- or chemically-induced trauma causes an inflammatory response in humans. In all of these diseases and conditions in man and in most mammals, activation of the complement system (a set of proteins, regulatory factors and proteolytic enzymes) via either the classical or the alternative pathway results in the generation of biologically active peptides which serve to amplify and exacerbate the resulting inflammation. The most active peptide, anaphylatoxin C5a, a 74-amino acid polypeptide, is generated by cleavage of the alpha-chain of native C5 at a specific site by convertases (proteolytic enzymes) " of the blood complement system as well as by enzymes of the coagulation system. C5a exists in vivo in two biologically active forms. Once it is liberated from C5, the carboxyl terminal arginine of C5a is rapidly removed by carboxypeptidase-N, leaving the des-.Arg derivative. Although C5a des-Arg is less active than C5a, both are potent inflammatory mediators at concentrations likely to be generated in vivo (Fernandez, H. N.; Henson, P. M.; Otani, A.; Hugli, T. E. J. Immunol . 1978, 120, 109.). Together, these peptides along with C3a, C4a, and their des-Arg degradation products, collectively described herein as anaphylatoxin, are capable of triggering diverse inflammatory reactions. Among the various cell types, the neutrophil response to C5a is the best defined. Cell surface receptors specific for C5a have been demonstrated on the neutrophil (Chenoweth, D. E.; Hugli, T. E. Proc. Natl . Acad. Sci . U.S. A . 1978, 75, 3943-3947. Huey, R.; Hugli, T. E. J. Immunol . 1985, 135, 2063-2068. Rollins, T. E.; Springer, M. S. J. Biol . Chem. 1985, 260, 7157-7160.), and the ligand-receptor interaction - promotes human polymorpho-nuclear leukocyte (PMN) migration in a directed fashion (chemotaxis) , adherence, oxidative burst, and granular enzyme release from these cells (Hugli, T. E. Springer Semin . Immunopathol . 1984, 7, 193-219.) . The interaction of C5a with PMN and other target cells and tissues results in increased histamine release, vascular permeability, smooth muscle contraction, and an influx into tissues of inflammatory cells, including neutrophils, eosinophils, and basophils (Hugli, T. E. Springer Semin . Immunopathol . 1984, 7, 193-219.). C5a may also be important in mediating inflammatory effects of phagocytic mononuclear cells tnat accumulate at sites of chronic inflammation (Allison, -A. C; Ferluga, J.; Prydz, H.; Scherlemmer, H. U. Agents and Actions 1978, 8, 27.). C5a and C5a des-Arg can induce chemotaxis in monocytes (Ward, P. A. J. Exp . Med. 1968, 128, 1201. Snyde.rman, R.; Shin, H. S.; Dannenberg, A. C. J". Immunol . 1972, 109, 896.) and cause them to release lysosomal enzymes (McCarthy, K.; Henson, P. S. J. Immunol . 1979, 123, 2511.) in a manner analogous to the neutrophil responses elicited by these agents. Recent studies suggest that C5a may have an immunoregulatory role by enhancing antibody particularly at sites of inflammation (Morgan, E. L.; Weigle, W. 0.; Hugli, T. E. J. Exp. Med. 1982, 155, 1412. Weigle, W. 0.; Morgan, E. L.; Goodman, M. G.; Chenoweth, D. E.; Hugli, T. E. Federation Proc. 1982, 41, 3099. Morgan, E. L.; Weigle, W. O.; Hugli, T. E. Federation Proc. 1984, 43, 2543.) . C5a and C5a des-Arg play important roles in host defenses against bacterial infections and possibly in the mediation of some pathologic lesions such as the leukocyte infiltration seen in the lungs during acute respiratory distress syndrome. This mechanism seems to play a role in different pathological situations like pulmonary distress during hemodialysis, leukophoresis, cardiopulmonary bypass, and in acute myocardial infarction. Complement activation has been postulated to play an important pathological role in rheumatoid arthritis, serum sickness, systemic lupus erythematosus, ulcerative colitis, and forms of hepatic cirrhosis, chronic hepatitis, and glomerulonephritis, in certain shock states, during hemodialysis, and cardiopulmonary bypass, acute pancreatitis, myocardial infarction (which may be worsened by C5a-induced leuko- e bolization following the interaction of complement with atheromatous plaques) , asthma, bronchoconstriction, some auto-al-lergic diseases, transplant rejection, and post-viral encephalopathies. By serving as antagonists by binding to and blocking the anaphylatoxin receptor, certain compounds of the present invention can reduce or prevent anaphylatoxin-mediated inflammation. Other compounds of the present invention are agonists that mimic anaphylatoxin activity, and assist the body in building its defense mechanism against invasion by infectious agents and malignancy. Additionally, these compounds may influence the immunoregulatory effects of anaphylatoxin. The possible involvement of anaphylatoxin in a wide range of diseases, as indicated by these examples, suggests that anaphylatoxin receptor ligands could have clinical applications for the treatment and prevention of the above-mentioned pathological conditions. Summary of f.he Tnvgnrion In accordance with the principal embodiment of the present invention, there are provided anaphylotoxin activity modifying compounds of the formula A-B-D-E-G-J-L-M-Q and the pharmaceutically acceptable salts, esters, or amides thereof. In the generic formula given above, the groups A through Q have the following values: A is R 3 .-R 2 -R 3 ; B is selected from R 4 -R 5 -R6, R35 and R37,. D is selected from R7-R 8 -R 9 and R35,- E is selected from Rιo~ R n~ R i2 and. R35; G is selected from R 13 -R 3 . 4 -R 15 and R35; J is selected from Ri6- R 17~ R 18 - n & R 35; L _ia selected from Ri9-R20~ R 2i anc R35; M_is_selected from a valence bond, R22~R23~ R 24, and R35,. Q is R25- R 26- R 27r * The group Ri is selected from the group consisting of aryl, lower alkyl, arylalkyl and hydrogen. R 2 is selected from the group consisting of >CRg9Rιoo and oxygen, with the proviso that when R2 is oxygen, Ri is aryl, lower alkyl or arylalkyl. R3 is selected from the group consisting of >C=0 and >CH2, with the proviso that when R 3 is >CH 2 then R 2 cannot be oxygen. R4 is >NRχoι where R 101 is hydrogen, lower alkyl, arylalkyl or alkenyl. R5 is selected from the group consisting of >CR 2 0i R 2 02, >N 203, > C SS CR205 R 206/ existing in either the Z- or E- configuration, and substituted cyclopropyl of the formula Raa. Rg, R9, R12, R15, R 1 8, R 21 and 2 are >C=0 *7, Rio, *13, *16, R19, and R22, are >NH. Rβ is selected from the group consisting of >CR 2 io R 21l / >NR2i3, existing in either the Z- or E- configuration, and substituted cyclopropyl of the formula Rll is selected from the group consisting of >CR2 2 0 R 22i, >NR223, existing in either the Z- or E- configuration, and substituted cyclopropyl of the formula R14 is selected from the group consisting of >CR23o R 23i, > R233, >C=CR235 R 236, existing in either the Z- or E- configuration, and substituted cyclopropyl of the formula "231. R 1 7 is selected from the group consisting of >CR 3 oi R 3 0 2 , >NR303, >C=CR305R 3 06»existing in either the Z- or E- configuration, and substituted cyclopropyl of the formula R 20 is selected from the group consisting of >CR 3 io 3iι, >C=C 3 i 5 R 3 i 6 , existing in either the Z- or ^-configuration, and substituted cyclopropyl of the formula R23 is selected from the group consisting of >CR320 R 32i, >C=CR 32 5R 326 , existing in either the Z- or ^-configuration, cyclopropyl of the formula R 25 is selected from the group consisting of >0 and >NRχo9 where R 109 is selected from hydrogen, lower alkyl and arylalkyl. R 26 is selected from the group consisting of hydrogen, lower alkyl, arylalkyl, and >NRχιo where R 3 . 10 is selected from hydrogen, lower alkyl, aryl, and arylalkyl, with the provisos that (i) when R 25 is >0 then R 26 is lower alkyl, and (ii) when R 26 is hydrogen, lower alkyl, or arylalkyl then R27 is absent. R27 is selected from the group consisting of hydrogen, lower alkyl, or aryl. R 35 is a group having the structure where f is an integer of 0 to 3, and X is >C=0. R is selected from hydrogen and lower alkyl, with the provisos that (i) when f is 0, X is at C-2 and R is at C-3 or C-4; (ii) when f is 1, X is at C-2 and R is at C-3, C-4 or C-5 and C-3,4 are saturated or unsaturated; (iii) when f is 2, X is at C-2, C-3 or C-4 and R is at C-2, C-3, C-4, C-5 or C-6 when the position is unoccupied by X and C-3,4 or C-4,5 are saturated or unsaturated and (iv) when f is 3, X is at C-2, C-3 or C-4 and R is at C-2, C-3, C-4, C-5, C-6 or C-7 when the position is unoccupied by X and C-3,4 or C-4,5 or C-5,6 are saturated or unsaturated. R37 is a group having the structure where h is 0 or 1 and j is 0 or 1 with the proviso that either h or j must be 1. R l and R2 1 taken together, optionally may represent a group selected from aryl or hydrogen. R2 - and R27 / taken together, optionally represent a group selected from hydrogen, with the proviso that when R25 is >0 then R26 and R27, taken together, represent hydrogen, lower alkyl or arylalkyl. Ri, R 2 and R3, taken together, optionally represent a group selected from lower alkyl, arylalkyl, alkenyl, hydrogen, or an N-terminal protecting group. R205, R206/ R215 R216, R225, R226, R235 R236, ^305, and R 306 are independently selected from the group consisting of hydrogen, lower alkyl, aryl, arylalkyl (.Arylalkyl is excluded from R 305 and R 306 when R i 9 - R 20~ R 2i represents an L-arginyl residue.), (cycloalkyl)alkyl, amidoalkyl (For R3 05 and R 306 , benzoyl amides and their heterocyclic variants are excluded when Rιg-R20~ R 2i represents an L-arginyl residue.), (carboxyamido)alkyl (For R3 0 5 and R 3 06, aniline amides and their heterocyclic variants are excluded when Ri9-R 2 0- 2 i represents an L-arginyl residue.), ureidoalkyl, and (heterocyclic)alkyl (For R 305 and R 306, when, R i9- R 20~ 2l represents an L-arginyl residue, then the heterocycle can only be separated by one methylene unit from the alpha-carbon.) . R315 and R316 are independently selected from the group consisting of hydrogen, lower alkyl, aryl, arylalkyl (Arylalkyl is excluded when R 22 ~ 23 ~ R 24 represents an L- arginyl residue.), and (cycloalkyl)alkyl; 99 r R202, R211, R221, R231, R302, R311 and R321 are independently selected from hydrogen, lower alkyl and arylalkyl. For R 302 and R 3 n, arylalkyl is limited to benzyl when R i9-R20~ R 2l and R 2 2~ 23~ R 24 respectively represent an L- arginyl residue. R l O O is hydrogen or lower alkyl. R 2 Λ 1 -is selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl, amidoalkyl, hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl, (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl, (thioalkoxy)alkyl, and sulfhydrylalkyl. ^203, ^213, R223, R233, and R303 are independently selected from the group consisting of hydrogen, lower alkyl. alkenyl, arylalkyl (Arylalkyl is limited to benzyl at R 3 0 3 when R 19 -R 2 0--R 21 represents an L-arginyl residue.), (cycloalkyl)alkyl, aminoalkyl (Aryl and arylalkyl amines are excluded from R303 when Rιg-R20~ R 2 i represents an L-arginyl residue.), amidoalkyl (Benzoyl amides and their heterocyclic variants are excluded from R 303 when Ri 9 -R2 0 - 2 i represents an L-arginyl residue.), hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl (Aniline amides and their heterocyclic variants are excluded from R 3 0 3 when Rιg- R 20 ~ R 2 i represents an L-arginyl residue.), (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl (When R i 9 - R 20 -R 2 i represents an L-arginyl residue, then the heterocycle at R 303 can only be separated by one methylene unit from the alpha-carbon.) , (thioalkoxy)alkyl and sulfhydrylalkyl, with the proviso that. none of the groups R 203, 213, 223, 233, or 303 πiay be a vinyl group or have a heteroatom directly attached to the nitrogen or separated from it by one methylene unit. R2 1 0 is selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl, amidinoalkyl, amidoalkyl, hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl, ureidoalkyl, (carboxyhydrazino)alkyl, (heterocyclic) lkyl, (thioalkoxy)alkyl and sulfhydrylalkyl. R 220 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl,. (cycloalkyl)alkyl, aminoalkyl, amidoalkyl, hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl, (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl, (thioalkoxy)alkyl and sulfhydrylalkyl. R 2 3 0 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl) lkyl, aminoalkyl, amidoalkyl, hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl, (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl, (thioalkoxy)alkyl and sulfhydrylalkyl. R 301 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl (.Arylalkyl is limited to benzyl when R ιg- 20 ~ R 21 represents an L-arginyl residue.), (cycloalkyl)alkyl, aminoalkyl (.Aryl and arylalkyl amines are excluded when R i 9 ~ R 2 0~ R 2l represents an L-arginyl residue.) , amidoalkyl (Benzoyl amides and their heterocyclic variants are excluded when Rιg-R 2 0~ R 2 i represents an L-arginyl residue.), hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl (Aniline amides of aspartyl residues and heterocyclic variants are excluded when i 9 - R 20 ~ R 2l represents an L-arginyl residue.), (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl (When Rιg-R 2 0~ R 2l represents an L-arginyl residue, then the heterocycle can only be separated by one methylene unit from the alpha-carbon.), (thioalkoxy)alkyl and sulfhydrylalkyl. R30 4 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl (Arylalkyl is excluded when R i 9 - R 2 0~ R 2 i represents an L- arginyl residue.), (cycloalkyl)alkyl, aminoalkyl (Aryl and arylalkyl amines are excluded when ιg- R 2 0- R 2l represents an L-arginyl residue.), amidoalkyl (Benzoyl amides and their heterocyclic variants are excluded when ιg- R 20~ R 2l represents an L-arginyl residue.), hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl (Aniline amides and heterocyclic variants are excluded when Rιg-R20~ R 21 represents an L-arginyl residue.), (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl (When Ri9-R 20 ~ R 2l represents an L-arginyl residue, then the heterocycle must be directly attached to the cyclopropyl ring.), (thioalkoxy)alkyl and sulfhydrylalkyl. R307 and R3 1 7 are independently selected from hydrogen; lower alkyl; aryl and arylalkyl, wherein arylalkyl is excluded for R307 and R317 when R i9- R 20- 2i and R 22~ 23 _ 24 respectively represent an L-arginyl residue. R310 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl (Arylalkyl is limited to benzyl when R 2 2~ R 23 ~ R 24 represents an L-arginyl residue.), (cycloalkyl)alkyl, aminoalkyl (Aryl and arylalkyl amines are excluded when 22 _ 23 ~ R 24 represents an L-arginyl residue.), amidoalkyl (When R 22 ~ R 23 -R 2 4 represents an L-arginyl residue, then benzoyl amides and their heterocyclic variants are excluded.), hydroxyalkyl, guanidinoalkyl, (carboxyamido)alkyl (.Aniline amides of aspartyl residues and heterocyclic variants are excluded when R 22~ 23~ R 24 represents an L-arginyl residue.), (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl (When 22~ 23~ R 24 represents an L-arginyl residue, then the heterocycle can only be separated by one methylene unit from the alpha-carbon.) , and sulfhydrylalkyl. R312 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl (Arylalkyl is excluded when R 22 _R 23 _ 24 represents an L- arginyl-_-r_esidue.) , (cycloalkyl)alkyl, aminoalkyl (Aryl and arylalkyl_amines are excluded when R 22 -R 23 ~ R 24 represents an L-arginyl residue.), amidoalkyl (When 22 - 23 _R 2 4 represents an L-arginyl residue, then benzoyl amides and their heterocyclic variants are excluded.), hydroxyalkyl, guanidinoalkyl, (carboxyamido)alkyl (Aniline amides and heterocyclic variants are excluded when R 22~ R 23~ R 24 represents an L-arginyl residue.), (carboxyhydrazino)alkyl. I Z. ureidoalkyl, (heterocyclic)alkyl (When R 22 ~ R 2 3 ~ R 24 represents an L-arginyl residue, then the heterocycle must be directly attached to the cyclopropyl ring.), and sulfhydrylalkyl. R 3 2 0 is selected from the group consisting of hydrogen, lower alkyl, aryl, arylalkyl, alkenyl, aminoalkyl, (cycloalkyl)alkyl and guanidinoalkyl. R- 3 25 and R 326 are independently selected from the group consisting of hydrogen, lower alkyl, aryl, arylalkyl, and (cycloalkyl)alkyl. R201 and R202, R210 and R211, R220 and R22I R230 and R 23l R 301 and R302 R310 and R311, R320 and R321, each pair taken together, independently may optionally represent -(CH2) Z - where z is an integer of from 2 to 6. R201 and R202/ R210 and R211, R220 and R221, R230 and 231, R301 and R302 R310 and R3n,and R320 and R321, each pair taken together, independently may optionally represent -CH2C6H CH 2 - where the two methylene chains are in an ortho configuration All of the foregoing definitions are with the provisos that, in the compounds of the present invention, (i) when more than one sulfhydrylalkyl is present in the compound, the compound exists in the oxidized disulfide form producing a cyclic molecule, or the two sulfhydryl moieties are connected by a C 2 to Cβ alkylene chain and (ii) when the compound contains a free amino group and carboxyl group, they can be cyclized to give the corresponding lactam. The present invention also relates to a method for modulating anaphylatoxin activity in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound of Claim 1. IS The invention further relates to an anaphylatoxin modulating compositions comprising a pharmaceutical carrier and a therapeutically effective amount of a compound of Claim 1. Df>ra-n.fa.r. r.-f>.«.-r.ripr-ion As discussed above, C5a is the most active of a class of biologically active peptides which serve to amplify and exacerbate inflammation. While C5a contains 74 amino acid residues, it has been found in accordance with the present invention that oligopeptides containing as few as six amino acid residues are also actively bound by C5a receptors. Moreover, it has been found that peptidomimetic compounds (i.e. compounds which mimic the activity of peptides) in which certain groups replace the α-carbon in oligopeptides are also actively bound by C5a receptors. The chemical structures of the compounds of the present invention are best understood by reference to the following structural formula in which it is understood that the segments are joined serially at the free valence bonds to form the compound A-B-D-E-G-J-L-M-Q. In one embodiment M is a valence bond and none of the residues is proline. I A i B | Q In another embodiment M is a valence bond and E is proline, (R 35 where F=l and R=H) . I A I B f D I E I I G I J I L I Q I In another embodiment if more than one sulfhydrylalkyl is present in the compound, then the compound can exist in the oxidized disulfide form producing a cyclic molecule. IS I A I B I I Q | M In another embodiment if the compound contains a free amino group and a free carboxyl group, then they can be cyclized to give the corresponding lactam. I A I B I D I E I G / I L I M As used throughout this specification and the appended claims, the following terms have the meanings specified. The term "alkyl" as used herein refers to monovalent straight chain or branched chain groups of 1 to 12 carbon atoms, including, but not limited to methyl, ethyl, n-propyi. I L isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, and the like. The term "lower alkyl" as used herein refers to straight or branched chain alkyl groups containing from 1 to 8 carbon atoms including but not limited to methyl, ethyl, n- propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, 2-methylhexyl, n-pentyl, 1-methylbutyl, 2,2-dimethylbutyl, 2-methylpentyl, 2,2-dimethylpropyl, n-hexyl and the like. The term "alkylene" as used herein refers to divalent groups of from one to twelve carbon atoms derived by the removal of two hydrogen atoms from straight or branched saturated hydrocarbons. Examples include -CH 2 -, -CH(CH 3 )-, -C(CH 3 )2-, -CH(C 2 H 5 )-, -CH 2 CH 2 -, -CH 2 CH(CH 3 )-, -C(CH 3 ) 2 C(CH3)2-/ -CH2CH2CH2- and the like. The term "alkenyl" as used herein refers to straight or branched chain groups of 2 to 12 carbon atoms containing a carbon-carbon double bond, including, but not limited to ethenyl, 1-propenyl, 2-propenyl, 2-methyl-1-propenyl, 1- butenyl, 2-butenyl, and the like. The term "cycloalkyl" as used herein refers to cyclic groups, of 3 to 8 carbons, including, but not limited to cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and the like. The term "(cycloalkyl)alkyl" as used herein refers to a cycloalkyl group appended to a lower alkyl group, including, but not limited to cyclohexyl ethyl and cyclohexylethyl. The term "alkoxy" as used herein refers to an alkyl group as defined above, attached to the remainder of the molecule through an oxygen atom. Alkoxy groups include, for example, methoxy, ethoxy, isopropoxy, n-butoxy, sec-butoxy, isobutoxy, tert-butoxy, and the like. The term "sulfhydrylalkyl" as used herein refers to a π -SH group appended to a lower alkyl group, as previously defined. The term "protected sulfhydrylalkyl" refers to a sulfhydrylalkyl group, as previously defined, which has been transformed to the corresponding 5-acetamidomethyl (S-Acm) or other similar protecting groups such as substituted or unsubstituted arylalkyl or t-butyl as known in the art, including, but not limited to S-phenacetamidomethyl. Typically used sulfhydrylalkyl protecting groups are described in: Gross, E.; Meienhofer, J. "The Peptides", Volume 3; Academic Press, 1981. The term "thioalkoxy" as used herein refers to an alkyl group, as previously defined, attached to the remainder of the molecule through a sulfur atom. Examples of thioalkoxy groups include, but are not limited to, thiomethoxy, thioethoxy, thioisopropoxy, n-thiobutoxy, sec-thiobutoxy, isothiobutoxy, tert-thiobutoxy and the like. The term " (thioalkoxy)alkyl" as used herein refers to a thioalkoxy group, as just defined, appended to a lower alkyl group. The term "(thioarylalkoxy)alkyl" as used herein refers to a group of the structure R 420 ~S- appended to a lower alkyl where R 420 is an arylalkyl group as defined below. The term "aryl" as used herein refers to substituted and unsubstituted carbocyclic aromatic groups including, but not limited to phenyl, 1- or 2-naphthyl, fluorenyl, (1,2)- dihydronaphthyl, (1,2,3,4)-tetrahydronaphthyl, indenyl, indanyl, and the like, wherein the aryl group may be substituted with 1, 2, or 3 substituents independently selected from halo, nitro, cyano, Ci to C 12 alkyl, alkoxy, aroyl and halosubstituted alkyl. The term "arylalkyl" as used herein refers to an aryl group, as previously defined, appended to an alkyl group, including, but not limited to benzyl, 1- and 2-naphthylmethyl, halobenzyl, alkoxybenzyl, hydroxybenzyl, aminobenzyl, nitrobenzyl, guanidinobenzyl, fluorenylmethyl, phenylmethyl(benzyl) , 1-phenylethyl, 2-phenylethyl, 1-naphthylethyl, and the like. The te.rm "benzyl" as used herein refers specifically to phenyl substituted methyl in which the phenyl group may be substituted with 1, 2, or 3 substituents independently selected from halo, nitro, cyano, alkyl of from one to twelve carbon atoms, alkoxy, aroyl, and halosubstituted alkyl, and the like. The term "aryloxy" as used herein refers to an aryl group as previously defined, attached to the parent molecular moiety through an oxygen atom. Aryloxy includes, but is not limited to phenoxy, 1-naphthoxy, 2-naphthoxy and the like. The term "arylalkoxy" as used herein refers to an arylalkyl group as previously defined, attached to the parent molecular moiety through an oxygen atom. Arylalkoxy includes, but is not limited to benzyloxy, 2-phenethyloxy, 1- naphthylmethyloxy and the like. The te.rm "aroyl" as used herein refers to an aryl group as defined above, attached to the parent molecule through a carbonyi group. Examples include benzoyl and substituted benzoyl. - The term "alkylamino" as used herein refers to a group having the structure -NH(alkyl) where the alkyl portion is as defined above. Alkylamino groups include, for example, methylamino, ethylamino, isopropylamino and the like. The term "dialkylamino" as used herein refers to a group having the structure -N(alkyl) (alkyl) where the two H alkyl groups may be the same or different and are as previously defined. The term "aminoalkyl" as used herein refers to a group having the structure -NR3 42 .R 343 appended to a lower alkyl group, as previously defined. The groups R 342 and R 343 are independently selected from hydrogen, lower alkyl, aryl and arylalkyl. Additionally, R3 42 and R 343 taken together, may optionally be -(CH 2 )mm"" where mm is an integer of from 2 to 6. The term "amidinoalkyl" as used herein refers to a group having the structure -NHC(=NH)R 3 so appended to a lower alkyl group, as previously defined. The group R35 0 is independently selected from lower alkyl, aryl, arylalkyl, and (cycloalkyl)alkyl. The term "amidoalkyl" as used herein refers to a group having the structure -NR 344 C(O)R 345 appended to a lower alkyl group, as previously defined. The groups R 344 and R 345 are independently selected from hydrogen, lower alkyl, aryl, arylalkyl, and halosubstituted alkyl. Additionally, R 344 and R345 taken together may optionally be -(CH2) kk - where kk is an integer of from 2 to 6. The term "carboxyalkyl" as used herein refers to a carboxyl group, -CO2H, appended to a lower alkyl group, as previously defined. The te.rm "(carboxyamido)alkyl" as used herein refers to a group, of the formula -C(0)NR 34 oR3 4 i, appended to a lower alkyl group, as previously defined. The groups R 34 0 and R341 are independently selected from hydrogen, lower alkyl, aryl and arylalkyl. Alternatively, R 340 and R 341 taken together may optionally be -(CH2) pp - wherein pp is an integer of from 2 to 6. 2θ The te.rm "(carboxyhydrazino)alkyl" as used herein refers to a group having the structure -C(0)NR 4 25NHR430 appended to a lower alkyl group, as previously defined. The groups R425 and R 43 0 are independently selected from hydrogen, lower alkyl, aryl and arylalkyl. The term "guanidinoalkyl" as used herein refers to a group of the structure -NR3 6 C<=NR 34 7)NHR 348 appended to a lower alkyl group, as previously defined. R 346 , R 34 7, and R 34 8 are independently selected from hydrogen, lower alkyl, heterocyclic, aminoalkyl and aryl. Alternatively, R 34 7 and R348 taken together may optionally be -(CH 2 )w~ wherein w is an integer of from 2 to 6. The term "ureidoalkyl" as used herein refers to a group having the structure -NHC(0)NH2 appended to a lower alkyl group, as previously defined. The term "heterocyclic" as used herein refers to any aromatic or non-aromatic 5- or 6-membered ring independently selected from the group consisting of one nitrogen, oxygen, or sulfur; one oxygen and one nitrogen; one sulfur and one nitrogen; one, two, or three nitrogens; wherein the 5- membered ring has 0 to 2 double bonds and the 6-membered ring has 0 to 3 double bonds, wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, wherein the nitrogen heteroatom may optionally be quaternized, and including any bicyclic group in which any of the above heterocyclic rings is fused to a benzene ring. Representative heterocycles include, but are not limited to pyrrolyl, pyrrolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, pyridyl, piperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, pyridazinyl, oxazoyl, oxazolidinyl, isoxazolyl, isoxazolidinyl, morpholinyl, indolyl, quinolinyl, thiazolyl, thiazolidinyl, isothiazolyl. 2 / isothiazolidinyl, isoquinolinyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, furyl, thienyl, and benzothienyl. The term " (heterocyclic)alkyl" as used herein refers to a heterocyclic group, as previously defined, appended to an alkyl group as previously defined. The term "hydroxyalkyl" as used herein refers to -OH appended to a lower alkyl group. The term "naturally occuring amino acid" refers to an amino acid selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine. The term "N-terminal protecting group" refers to those groups, as known in the art, intended to protect the N- terminus against undesirable reactions during synthetic procedures or to prevent the attack of exopeptidases on the final compounds or to increase the solubility of the final compounds and includes, but is not limited to acyl, acetyl, pivaloyl, tert-butylacetyl, tert-butyloxycarbonyl (Boc) , carbobenzyloxycarbonyl (Cbz) , and benzoyl groups. Other groups are described in: Gross, E.; Meienhofer, J. "The Peptides", Volume 3; Academic Press, 1981. T.he te.rm "anaphylatoxin" is used herein to mean C5a, C4a, C3a,-or the corresponding des-Arg degradation products. The term "pharmaceutically acceptable salt" refers to non-toxic acid addition salts such as salts formed with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid and perchloric acid or with organic acids such as acetic acid, oxalic acid, maleic acid, malic acid, tartaric acid, citric acid, succinic acid or -Z.-2, malonic acid. Other pharmaceutically acceptable salts include inorganic nitrate, sulfate, acetate, malate, formate, lactate, tartrate, succinate, citrate, p-toluenesulfonate, and the like, including, but not limited to cations based on the alkali and alkaline earth metals, such as sodium, lithium, potassium, calcium, magnesium, and the like, as well as nontoxic ammonium, quaternary ammonium, and amine cations, including, but not limited to ammonium, tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, ethylamine, and the like. Examples of pharmaceutically acceptable, non-toxic esters of the compounds of this invention include Ci to Cζ alkyl esters wherein the alkyl group is straight or branched chain. Acceptable esters also include C 5 to C 7 cycloalkyl esters as well as arylalkyl esters such as, but not limited to benzyl. Ci to C 4 alkyl esters are preferred. Esters of the compound of formula I may be prepared according to conventional methods. Examples of pharmaceutically acceptable, non-toxic amides of the compounds of this invention include amides derived from ammonia, primary Ci to Cs alkyl amines and secondary Ci to Cς dialkyl amines wherein the alkyl groups are straight or branched chain. In the case of secondary amines the amine may also be in the form of a 5 or 6 membered heterocycle containing one nitrogen atom. Amides derived from .ammonia, Ci to C 3 alkyl primary amides and Ci to C 2 dialkyl secondary amides are preferred. Amides of the compound of formula I may be prepared according to conventional methods. Numerous asymmetric centers may exist in the compounds of the present invention. The present invention contemplates the various stereoisomers and mixtures thereof. In 2.3 particular, chiral centers can exist at R5, Re, R 11 , R 14 , R 1 7, R 20 and R 23 - Compounds of the present invention containing up to three α-amino acid residues of non-natural configuration have been found to be effective as modulators of anaphylotoxin activity. Particular stereoisomers are prepared by selecting the starting amino acids or amino acid analogs having the desired stereochemistry and reacting these starting materials by the methods detailed below. Starting compounds of particular stereochemistry are either commercially available or are made by the methods detailed below and resolved by techniques well known in the organic chemical arts. One class of preferred compounds of the present invention are those in which the group R5 is preferably selected from >CR2oi R 202 where R 201 is selected from aryl and arylalkyl; R 202 is selected from the group consisting of hydrogen and lower alkyl; >NR 20 3 where R 203 is arylalkyl; >C=CR205 206, existing in the Z- or ^-configuration where R 205 is selected from the group consisting of hydrogen and lower alkyl; R2 06 is chosen from the group consisting of aryl or the formula and arylalkyl and R 202 is selected from the group consisting of hydrogen and lower alkyl. In another class of preferred compounds of the present invention are those wherein \W % is preferably selected from the group consisting of >CR2io R 2l i where R 21 0 s selected from the group consisting of arylalkyl; aminoalkyl; guanidinoalkyl; and lower alkyl; R 211 is selected from hydrogen and lower alkyl; >NR2i 3 where R 213 is selected from the group consisting of arylalkyl; aminoalkyl; guanidinoalkyl; and lower alkyl; with the proviso that R 213 .may not have a heteroatom directly attached to the nitrogen or separated from it by one methylene unit; >C=CR2i5 R 2i6, existing in either the Z- or ^.-configuration where R 21 5 is selected from hydrogen and lower alkyl; R 216 is selected fro arylalkyl and lower alkyl; and substituted cyclopropyl of th fcrmula where R 210 is selected from the group consisting of arylalkyl; aminoalkyl; guanidinoalkyl; and lower alkyl; R 211 is selected from hydrogen and lower alkyl. The group R 3 .7 preferably is selected from the group consisting of >CR 3 oi R 302 where R 301 is selected from the group consisting of lower alkyl; arylalkyl (Arylalkyl is limited to benzyl when Ri 9 -R 20 " R 2l represents an L-arginyl residue.); R 302 is selected from hydrogen and lower alkyl; >NR303; 303 i selected from the group consisting of hydrogen; lower alkyl; (cycloalkyl)alkyl; and arylalkyl (Arylalkyl is limited to benzyl when Ri 9 ~R 20 ~ R 2 i represents an L-arginyl residue.); existing in either the Z- or JET-configuration; R 30 5 is selected from hydrogen and lower alkyl; R 306 is selected from aryl, arylalkyl (Arylalkyl is excluded when R ιg- 2 0 ~ R 2l represents an L-arginyl substituted cyclopropyl of the formula ¥" ^ R307 where 304 is selected from the group consisting of lower alkyl; aryl; arylalkyl (Arylalkyl is excluded when R ιg-R 20 ~ R 2l represents an L-arginyl residue.); and (cycloalkyl)alkyl; R 30 7 is selected from hydrogen and lower alkyl. The group R2 0 is preferably selected from the group consisting of >CR 3 io R 3 iι where R 310 is selected from the group consisting of arylalkyl (Arylalkyl is limited to benzyl ZS when R 22 ~ R 2 3~ R 2 4 represents an L-arginyl residue.); and guanidinoalkyl; 3 iι is selected from hydrogen and lower alkyl; existing in either the Z- or E- configuration where R3 15 is selected from hydrogen and lower alkyl; R 316 is selected from arylalkyl (Arylalkyl is excluded when R22~ R 23~ R 24 represents an L-arginyl residue.) and aryl; and substituted cyclopropyl of the formula where R 31 2 is selected from the group consisting of aryl, arylalkyl (Arylalkyl is excluded when R 2 2~ 23 ~ 24 represents an L- arginyl residue.) and guanidinoalkyl; R 311 is selected from hydrogen and lower alkyl. One class of preferred compounds of the present invention are those in which when G and L are alpha amino acid residues, the chirality of R 14 and R 20 is of the D- or unnatural configuration. One class of preferred compounds of the present invention are those in which R 4 , R7, Rio, Rj. 3 , Riβ, Ri , and R22 are >NH; or R 4 , R 7 , R 13 , Rig, R 19 , and R 22 are >NH and E is R 35 . Another class of preferred compounds are those in which R 1 -R 2 -R 3 taken together is independently selected from hydrogen, lower alkyl or acetyl. One class of preferred compounds of the present invention are those in which the groups Re, Rg, R 12 , R i 5 R 18 , R 2 1 , and R 2 4 are independently selected from >C=0. Specific examples of compounds, as well as their pharmaceutically acceptable salts, esters, and amides, contemplated as falling within the scope of the present invention include, but are not necessarily limited to, the following: ^ H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexyIpropanoyl}- DLeucyl-DArginyl-OH; H-(p-Iodo)Phenylalanyl-Lysyl-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl- DAlanyl-Arginyl-OH; H-Phenylalanyl-Lysyl-Prolyl-DLeucyl-{ (2S)-2-Amino-3- cyclohexylpropanoy1}-DArginyl-OH; H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-Leucy1-DPhenylalanyl-Arginy1-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DTyrosyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Prolyl-DPhenylalanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Alany1-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DLeucy1-Arginy1-OH; H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl- DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-D(1-Naρhthylalanyl)- Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DPhenylalanyl-{ (2S)-2- Amino-3-cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl- DNorleucyl-OH. In one embodiment of the present invention i3-Ri4~Rl5 taken together is { (2R)-2-amino-3-cyclohexylpropanoyl} . Representative examples of this embodiment include the following compounds, as well as their pharmaceutically acceptable salts, esters, and amides: (N-Methyl)Phenylalanyl-Lysyl-Tyrosyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Glutamyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Lysyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-(1-Naphthylalanyl)-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; H-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-{ (2R/S)-2-Amino-5-phenyl- pentanoyl}-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-Pheny1- alanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3-cyclo- hexylpropanoyl}-Tryptophanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Arginyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; N-Acetyl-{ (Z)-2-Amino-3-phenyl-2-propenoyl}-Lysyl-Prolyl- { (2R)-2-.Amino-3-cyclohexylpropanoyl}-Phenylalanyl- DArginyl-OH; (N-Methyl)-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DPhenylalany1-OH; (N-Methyl)Phenylalanyl-Lysyl-Tryptophanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; H-Phenylalanyl-Lysyl-Azaglycyl-{ (2R)-2-Amino-3-cyclo¬ hexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hex lpropanoyl}-Norleucyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-{ (R)-Phenylglycinyl}-OH; (N-Methyl)Phenylalanyl-Lysyl-{ (2S)-2-Amino-4-pentenoyl}- { (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl- DArginyl-OH; (N-Methyl) (2R/S) (3-F)Phen lalanyl-Lysyl-Prolyl-{ (2R)-2-Amino- 3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH; H-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-Leucyl-DArginyl-OH. In another embodiment of the present invention R13-R14- R 1 5 taken together is { (2R)-2-amino-3-cyclohexylpropanoyl} and i6~Ri7 _ R l 8 taken together is { (2S)-2-amino-3- cyclohexylpropanoyl} . Representative examples of this embodiment include the following compounds, as well as their pharmaceutically acceptable salts, ester, and amides: H-Phenylalanyl-Lysyl-Proly1-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; H-{ (R/S)-t-Butylalanyl}-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexyipropanoyl}-{ (2S)-2-.Amino-3-cyclohexylpropanoyl}- DArginyl-OH; (N-Methyl)Phenylalanyl-Ornithyl-Prolyl-{ (2R)-2-Amino-3- cyclohex lpropanoyl}-{ (2S)-2-Amino-3-cyclohexy1- propanoyl}-DArginyl-OH; (N,N-Dimethyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Arginyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; H-Phenylalanyl-Arginyl-Prolyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Arginyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; H-Phenylalanyl-Lysyl-Lysyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; N-Acetyl-{ (IR/S) (2R/S) ( (Z)-l-Amino-2-phenylcyclopropyl)-1- carbonyl}-Lysyl-Alanyl-{ (2R)-2-Amino-3-cyclohexy1- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Arginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-{ (2S)-2-.Amino-3-cyclohexylpropanoyl}- DTryptophanyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-N-(Me) (Benzyl) ; H-Phenylalanyl-Ornithyl-Prolyl-{ (2R)-2-.Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; H-Phenylalanyl-Lysyl-Phenylalanyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; N-Acetyl-Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Leucyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; (N-Methyl)Phenylalany1-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; (N-Methyl)Phenylgl cyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexyl- propanoy1}-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{(2R)-2-Amino-3-cyclo- hexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; (N-Methyl)Phenylalan l-Norleucyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-.Amino-3-cyclohexyl- propanoyl}-D.Arginyl-OH; H-Phenylalanyl-Lysyl-Arginyl-{(2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Tyrosyl-{ (2R)-2-_Amino-3- cyclohexylpropanoyl}-{ (2S)-2-.?imino-3-cyclohexyl- propanoyl}-D.Arginyl-OH; (N-Methyl) " Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)- Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2- Amino-3-cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; (N-Benzyl)DProlyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohexy1- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH. Method of Treatment The compounds of the present invention serve to modulate the activity of anaphylatoxin. Certain compounds of the present invention function as anaphylatoxin antagonists, while others function as agonists. The antagonist compounds of the present invention block the anaphylatoxin receptor and prevent anaphylatoxin activity, which makes those compounds useful in the treatment and prevention of injurious conditions or diseases in which anaphylatoxin may be involved. Disease states in which anaphylatoxin is involved include asthma, bronchial allergy, chronic inflammation, systemic lupus erythematosus, vasculitis, serum sickness, angioedema, rheumatoid arthritis, osteoarthritis, gout, bullous skin diseases, hypersensitivity pneumonitis, idiopathic pulmonary fibrosis, immune complex-mediated glomerulonephritis, psoriasis, allergic rhinitis, adult respiratory distress syndrome, acute pulmonary disorders, endotoxin shock, hepatic cirrhosis, pancreatitis, inflammatory bowel diseases (including Crohn's disease and ulcerative colitis), thermal injury. Gram-negative sepsis, necrosis in myocardial infarction, leukophoresis, exposure to medical devices (including but not limited to hemodialyzer membranes and extracorpeal blood circulation equipment) , chronic hepatitis, transplant rejection, post-viral encephalopathies, and/or ischemia induced myocardial or brain injury. These compounds may also be used as prophylactics for such conditions as shock accompanying Dengue fever. In addition, a combination of antibiotic and anti-inflammatory agent such as corticosteroids (e.g., methylprednisolone) and one or more of the above mentioned compounds may be employed. Certain compounds of the invention are useful therapeutic agents because of their ability to mimic or promote anaphylatoxin activity and are therefore useful in stimulating the inflammatory response and immune response in mammals who are deficient in this regard. These agonist compounds may be used to assist the body in building its defense mechanism against invasion by infectious microorganisms or other stress. Interaction by these agonists at the anaphylatoxin receptor makes them useful in treating conditions or diseases including, but not limited to cancers (including but not limited to lung carcinoma), immunodeficiency diseases, and severe infections. In some cases this will involve preventing the underlying cause of the disease state and in other cases, while the underlying disease will not be affected, the compounds of this invention will have the benefit of ameliorating the symptoms or preventing the manifestations of the disease. The compounds of the present invention may be administered orally, parenterally, by inhalation spray, rectally, or topically in dosage unit formulations containing conventional nontoxic pharmaceutically acceptable carriers, adjuvants and vehicles as desired. The term "parenteral" as used herein includes subcutaneous, intravenous, intramuscular, intrasternal, intra-arterial injection or infusion techniques, without limitation. The term "topically" encompasses administration rectally and by inhalation spray, as well as by the more common routes of the skin and the mucous membranes of the mouth and nose. Actual dosage levels of active ingredients in the pharmaceutical compositions of this invention may be varied so as to achieve the desired therapeutic response for a particular patient, compositions, and mode of administration. The selected dosage level will depend upon the activity of the particular compound, the route of administration, the severity of the condition being treated, and the condition and prior medical history of the patient being treated. However, it is within the skill of the art to start doses of the compound at levels lower than required for to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved. Generally dosage levels of about 0.001 mg to about 100 mg, more typically from about 0.1 mg to about 20 mg, of active compound per kilogram of body weight per day are administered daily to a mammalian host. If desired, the effective daily dose may be divided into multiple doses for purposes of administration, e.g. two to four separate doses per day. Formulation of Pharmaceu ical Composition Pharmaceutical compositions of this invention for parenteral injection comprise pharmaceutically acceptable sterile aqueous or nonaqueous solutions, dispersions, suspensions or emulsions as well as sterile powders for reconstitution into sterile injectable solutions or dispersions just prior to use. Examples of suitable aqueous and nonaqueous carriers, diluents, solvents or vehicles include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol, and the like), and suitable mixtures thereof, vegetable oils (such as olive oil) , and injectable organic esters such as ethyl oleate. Proper 3W fluidity can be maintained, for example, by the use of coating materials such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants. These compositions may also contain adjuvants such as preservative, wetting agents, emulsifying agents, and dispersing agents. Prevention of the action of microorganisms may be ensured by the inclusion of various antibacterial and antifungal agents, for example, paraben, chlorobutanol, phenol, sorbic acid, and the like. It may also be desirable to include isotonic agents such as sugars, sodium chloride, and the like. Prolonged absorption of the injectable pharmaceutical form may be brought about by the inclusion of agents which delay abdorption such as aluminum monostearate and gelatin. If desired, and for more effective distribution, the compounds can be incorporated into slow release or targeted delivery systems such as polymer matrices, liposomes, and microspheres. The injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter, or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium just prior to use. Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound is mixed with at least one inert, pharmaceutically acceptable excipient or carrier such as sodium citrate or dicalcium phosphate and/or a) fillers or extenders such as starches, lactose, sucrose, glucose, mannitol, and silicic acid, b) binders such as, for example, carboxymethylcellulose, alignates, gelatin, polyvinylpyrrolidone, sucrose, and acacia, c) humectants such as glycerol, d) disintegrating agents such as agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates, and sodium carbonate, e) solution retarding agents such as paraffin, f) absorption accelerators such as quaternaryammonium compounds, g) wetting agents such as, for example, cetyl alcohol and glycerol monostearate, h) absorbents such as kaolin and bentonite clay, and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof. In the case of capsules, tablets and pills, the dosage form may also comprise buffering agents. Solid compositions of a similar type may also be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugar as well as high molecular weight polyethylene glycols and the like. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings and other coatings well known in the pharmaceutical formulating art. They may optionally contain opacifying agents and can also be of a composition that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of embedding compositions which can be used include polymeric substances and waxes. The active compounds can also be in micro-encapsulated form, if appropriate, with one or more of the above-mentioned excipients. Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups and elixirs. In addition to the active 3fc compounds, the liquid dosage forms may contain inert diluents commonly used in the art such as, for example, water or other solvents, solubilizing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3- butylene glycol, dimethyl formamide, oils (in particular, cottonseed, groundnut, corn, germ, olive, castor, and sesame oils) , glycerol, tetrahydrofurfuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof. Besides inert diluents, the oral compositions can also include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents. Suspensions, in addition to the active compounds, may contain suspending agents as, for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar, and tragacanth, and mixtures thereof. Compositions for rectal or vaginal administration are preferably suppositories which can be prepared by mixing the compounds of this invention with suitable non-irritating excipients or carriers such as cocoa butter, polyethylene glycol or a suppository wax which are solid at room temperature but liquid at body temperature and therefore melt in the rectum or vaginal cavity and release the active compound. Dosage forms for topical administration of a compound of this invention include powders, sprays, ointments and inhalants. The active compound is mixed under sterile conditions with a pharmaceutically acceptable carrier and any needed preservatives, buffers, or propellants which may be required. Opthalmic formulations, eye ointments, powders and solutions are also contemplated as being within the scope of this invention. anaphylatoxin Receptor Binding Ki Determination Specific inhibition of C5a binding activity of representative compounds of the present invention was measured using 0.03-1 nM 1 5 I-C5a with 2.5-25 ug/mL of purified PMNL membrane fragments (Borregaard, N.; Heiple, J. M.; Simons, E. R.; and Clark, R. A. J. Cell . Biol . 1983, 97, 52-61.). Free and membrane-bound ligand were separated by filtration. Binding potencies for representative examples of compounds of this invention are listed in Table 1. Table 1 In vitro C5a Receptor Binding Potency of Compounds of this Invention. Example Ki μM Example Ki μM 3& ■gym-haggis r>Ψ t-hg Com u s The novel compounds and salts thereof of the invention can be utilized effectively as therapeutic agents. Accordingly, the present invention further relates to therapeutic compositions comprising a novel compound having the general formula I or salts thereof as an active component. The compounds of the invention may be prepared by a synthetic method of elongation of a peptide chain through condensation of one amino acid by one, or by a method of coupling fragments consisting of two or several amino acids, or by a combination of these methods in accordance with conventional peptide synthesis methods. The condensation of two amino acids, the condensation of an amino acid with a peptide or the condensation of one peptide with another peptide may be effected in accordance with conventional condensation methods such as azide method, mixed acid anhydride method, symmetrical anhydride method, DCC (dicyclohexylcarbodiimide) method, active ester method (p-nitrophenyl ester method, N-hydroxysuccinimide ester method, cyanomethyl ester method and the like) , Woodward reagent K method, DCC-HOBT(l-hydroxy-benzotriazole) method and the like. These condensation reactions may be done by either solution methods or solid phase synthetic methods. When the peptide chain is elongated by the solid phase method, the C-terminal amino acid is linked to an insoluble carrier. As the insoluble carrier, any that can produce a detachable bond by reacting with a carboxyl group in a C- terminal amino acid may be used, and the examples thereof involve, for example, halomethyl resins such as chloromethyl resin, bromomethyl resin and the like, hydroxy-methyl resin. SI benzhydrylamine resin, and t-alkyloxycarbonyl hydrazide resin. As conventional polypeptide synthesis, branched chain amino and carboxyl groups at alpha and omega positions in amino acids may be protected/deprotected if necessary. The protecting groups for amino groups which can be used involve, for example, benzyloxycarbonyl (Z), o-chlorobenzyloxycarbonyl ( (2-C1)Z) , p-nitrobenzyloxycarbonyl (Z (NO 2 )) , p-methoxy- benzyloxycarbonyl (Z(OMe)), t-butoxycarbonyl (Boc) , t- amyloxycarbonyl (Aoc) , isobornyloxycarbonyl, admantyloxycarbonyl, 2-(4-biphenyl)-2-propyloxycarbonyl (Bpoc) , 9-fluorenyl-methoxycarbonyl (Fmoc) , methylsulfonylethoxycarbonyl (Msc) , trifluoroacetyl, phthalyl, formyl, 2-nitrophenylsulfenyl (Nps) , diphenylphosphinothioyl (Ppt), and dimethylphosphinothioyl (Mpt) . The examples of protecting groups for carboxyl groups involve, for example, benzyl ester (OBn) , cyclohexyl ester, 4-nitrobenzyl ester (OBnNθ2) , t-butyl ester (OtBu) , 4-picolyl ester (OPic) and the like. In the course of the synthesis of the present novel compounds, specific amino acids having functional groups other than amino and carboxyl groups in the branched chain such as arginine, cysteine, serine, and the like may be protected, if necessary, with suitable protecting group. It is preferable that for example, the guanidino group (N G ) in arginine may be protected with nitro, p-toluenesulfonyl (Tos) , benzyloxycarbonyl (Z) , adamantyloxycarbonyl (Adoc) , p- methoxybenzenesulfonyl, 4-methoxy-2, 6-dimethylbenzene- sulfonyl (Mds), 1,3,5-trimethylphenylsulfonyl (Mts) and the like, and the thiol group in cysteine may be protected with benzyl, p-methoxybenzyl, triphcnyl ethyl, acetamidomethyi, MO ethylcarbamyl, 4-methylbenzyl (4-MeBn), 2,4,6-trimethylbenzyl (Tmb) and the like, and the hydroxyl group in serine may be protected with benzyl (Bn) , t-butyl, acetyl, tetrahydropyranyl and the like. N-Acetylated peptides were prepared in analogy to Example 120. The following literature procedures were used to prepare N-alkyl- or N,N-dialkyl-amino acid derivatives. Lovett, J. A.; Portoghese, P. J". Afed. Chem. 1987, 30, 1144- 1149. Borch, R. F.; Hassid, A. I. J". Org. Chem. 1972, 37, 1673-1674. Hansen, D. W.; Pilipauskas, D. J. Org. Chem. 1985, 50, 945-950. Grieco, P. A.; Basha, A. J. Org. Chem. 1987, 52, 5746-5749. Shuman, R. T.; Smithwick, E. L.; Smiley, D. L.; Brooke, G. S.; Gesellchen, P. D. "Peptide: Structure and Function", Proceedings of the Eighth American Peptide Symposium, 1984; p 143-146. Cheung, S. T.; Benoiton, N. L. Can. J. Chem. 1977, 55, 906-910. These reactions were carried out either on the elongated peptide-resin or on amino acid derivatives and then incorporated into the peptide- resin. The preparation of (2RS)-2-amino-5-phenylpentanoic acid is described in: Greenstein, J. P.; Winitz, M. "Chemistry of the .Amino Acids"; John Wiley and Sons, Inc. : New York, 1961; Vol III, p.2387. (N-Boc)-(2R)-2-Amino-3-cyclohexylpropanoic acid: A solution of Boc-D-phenylalanine (50 g, 0.19 mol) in methanol (500 mL) was hydrogenated at room temperature at 4 atms with 5% rhodium on alumina (5.0 g) . Removal of catalyst by filtration and evaporation yielded the product quanititatively. The (2S)-isomer was prepared in an identical manner from Boc-L-phenylalanine. The following literature procedures were used to prepare N-guanidino substituted arginine derivatives: \ Mathias, L. J., Synthesis 1979, 561-576; Maryanoff, C. A.; Stanzione, R. C; Plampin; J. M.; Mills, J. E. J. Org. Chem. 1986, 51 , 1882-1884; Nestor, J. J.; Ho, T. L.;Simpson, R. A.; Homer, B. L.; Jones, G. H.; McRae, G. I.; Vickery, B. H. J. Med. Chem. 1982, 25, 795-801. The obtained arginine derivatives were attached to Merrifield resin as described in: Stewart, J. M.; Young, J. D."Solid Phase Peptide Synthesis", 2nd edition; Pierce Chemical Co.: Rockford, Illinois, 1984; p 71-72. The amino acid resin obtained was used to construct the peptide, followed by cleavage and purification to yield the desired peptide analog. C-terminal esters and acyl hydrazides were prepared as described in: Stewart, J. M.; Young, J. D."Solid Phase Peptide Synthesis", 2nd edition; Pierce Chemical Co.: Rockford, Illinois, 1984. Disulfides were made according to the method described by: Rich, D. H.; Kawai, M.; Goodman, H. L.; Suttie, J. W. J. Med. Chem . 1983, 25, 910. The compounds of the invention were prepared by standard solid phase peptide synthesis conditions as described in "Solid Phase Peptide Synthesis" by J. M. Stewart and J. D. Young, Second Edition (1984) and illustrated in Examples 1 and 2 in the experimental section. The compounds of the invention may also be prepared by partial solid phase synthesis, fragment condensation methods and classical solution methods as exemplified by the methods described in "Peptide Synthesis", Second Edition, M. Bodanszky, Y. S. Klausner, and M. A. Ondetti (1976) . The standard chirality descriptors "R" and "S" are used to indicate an isomerically pure center, "RS" to indicate a mixture, and "R/S" to indicate a single pure isomer ot Z undete.rmined configuration. The descriptor "±" refers to a d,l mixture of amino acids at the indicated residue. The descriptor "*" or "**" when written in a chemical name indicates the site of a disulfide or amide linkage, respectively. The foregoing may be better understood by reference to the following examples which are provided for illustration and not limitation of the practice of the invention, unless otherwise indicated, the standard peptide methods described above and in examples 1 and 2 were used to assemble the different products, using the precursors indicated by the specific peptide sequence. The product was at least 95% pure, and gave NMR and mass spectra consistent with the proposed structure. Example 1 H-Phenylalanyl-Lysyl(N-epsilon-Cbz)-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl(N-guanidino-Tos)-Merrifield Resin Boc-DArginine(N-guanidino-Tos)-Merrifield resin (0.4- 1.0 g) was placed in a solid phase peptide synthesis vessel and amino acids were attached to the resin sequentially in the following order: Boc-(2S)-2-Amino-3-cyclohexylpropanoic acid, Boer-(2R)-2-Amino-3-cyclohexylpropanoic acid, Boc- Proline, (N-alpha-Boc,N-epsilon-Cbz)Lysine, Boc- Phenylalanine, according to the protocol outlined in Agenda A to yield the protected peptide resin: H-Phenylalanyl-Lysyl(N- epsilon-Cbz)-Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl(N-guanidino- Tos)-Merrifield resin. Following the synthesis, the protected peptide resin was removed from the reaction vessel by washing the resin three times with 20 mL DMF into a 30-60 mL sintered U3 glass funnel, followed by washing the resin three times with 20 mL methylene chloride. The resin was dried at least five hours, then weighed. Agenda A 1. Deblock: 45% trifluoroacetic acid (TFA) in methylene chloride containing 2.5% anisole (v/v/v) . 2. Neutralization: 10% diisopropylethylamine (DIEA) in methylene chloride (v/v) . 3. Single Coupling: 0.2-0.4M Boc-amino acid derivative in N,N-dimethylformamide (DMF), 0.2-0.4 M diisopropylcarbodiimide (DIC) in methylene chloride, reaction time, 60 minutes. 4. Resin base washing: 10% DIEA in methylene chloride (v/v) . 5. Single Coupling repeated: same as Step 3. 6. Go to next amino acid residue (go back to Step 1) . 7. Upon attachment of the final amino acid to the growing peptide chain, the protecting group (t-Boc) is removed as in Step 1. Example 2 H-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH The protected peptide resin of Example 1 (0.6 g) was treated with 1.0 mL anisole and 10 mL hydrogen fluoride (HF) for 60 minutes at 0 °C. The HF and anisole were removed in vacuo at 0 °C, and the mixture of the peptide and resin was washed with diethyl ether (2 x 25 mL) . The crude peptide was extracted from the mixture by treatment with portions of 20% aqueous acetic acid (4 x 25 mL) , iyophilized to a dry 4 amorphous powder, and purified by high performance liquid chromatography (HPLC) {column: 21.4 mm ID x 25 cm or 41.4 mm ID x 25 cm, Dynamax (Rainin) , 8 um silica, C18 reverse-phase column}. The sample was purified by gradient elution {from 20 to 60% (80% acetonitrile in water with 0.1% trifluoroacetic acid) } at a flow rate of 15-45 mL/min. FAB + MS: (M+H) + =853 Example 3 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-NHBenzyl N-Boc-D-Arginine hydrochloride (100 mg, 0.3 mmol) was coupled with benzylamine (40 uL, 0.4 mmol) using the mixed anhydride method described in Example 322 to give N-Boc-D- arginine benzylamide. The Boc group was removed by treatment with 4 M hydrochloric acid in dioxane for 1 h. The resulting D-arginine benzylamide was coupled to N-Boc-(N- methyl)phenylalanyl-lysyl(N-epsilon-Boc)-prolyl-{ (2R)-2- amino-3-cyclohexylpropanoyl}-{ (2S)-2-amino-3- cyclohexylpropanoyl}-OH, which was prepared as described in Example 322, using l-(3-dimethyl-aminopropyl)-3-ethyl carbodiimide hydrochloride in dimethylformamide using the method-described in Example 322. The crude product was deprotected with 50% trifluoroacetic acid in methylene chloride. The material thus obtained was purified by HPLC as described in Example 2 to give the title compound in 26% overall yield. FAB÷ MS: (M+H) + =956 Amino Acid Anal. : PheMe (0.83), Lys (1.00), Pro (1.00), Cha (1.86), Arg (1.00) Example 4 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Ornithyl-OH F.AB + MS: (M+H) + »898 Example 5 H-{ (R/S)-t-Butylalanyl}-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + «833 .Example 6 H-{ (R/S)-t-Butylalanyl}-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H) + =833 Ex-ample 7 H-{3-(2 • -Thienyl)alanyl}-Lysyl-Prolyl-D{3-(2 • - Thienyl)alanyl}-{3-(2 • -Thienyl)alanyl}-DArginyl-OH FAB + MS: (M+H)+«859 Example 8 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl-{ (2R) 2-Amino-3-rcyclohexylpropanoyl}-DProlyl-DArginyl-OH FAB+ MS: (M+H) + -893 Amino Acid Anal. : Pro (2.15), Phe (1.06), Cha (0.88), Lys (0.94), Arg (0.97) Example 9 H-Phenylalanyl-Lysyl-Cysteinyl*-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Penicillaminyl*-Arginyl-OH 4U FAB + MS: (M+H) + «988 Example 10 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{ (R/S)-2-Benzyl-arginyl}-OH This compound was prepared in analogy to Example 378. FAB + MS: (M+H) + -951 Amino Acid Anal.: PheMe (0.81), Lys (0.99), Pro (1.02), Cha (0.95), Phe (1.04) Example 11 H-{ (2S)-2-Amino-3-cyclohex lpropanoyl}-Lysyl-Prolyl-{ (2R)-2- Amino-3-cyclohex lpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =853 Amino Acid Anal.: Pro (0.99), Phe (1.04), Cha (1.93), Lys (0.86), Arg (1.17) Example 12 H-Phenylalanyl-DLysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohex lpropanoyl}- D.Arginyl-OH FAB + MS: (M+H) + =827 Example 13 N-Acetyl-Histidyl-Lysyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl- OH FAB+ MS: (M+H) + =972 Example 14 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-DPhenylalanyl-{p-Chloro-DPhenylalanyl}- OH *T7 This compound was prepared in analogy to Example No. 322. FAB+ MS: (M+H) + =886 Example 15 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{D-4-Chlorophenylalanyl}-0H This compound was prepared in analogy to Example No. 322. FAB+ MS: (M+H) + «886 Example 16 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohex lpropanoyl}-{ (2,3R/S)-2-Amino-3-phen lpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=875 Example 17 (N-Methyl)Phenylalanyl-Ornithyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + -853 Amino Acid Anal. : PheMe (0.89), Orn (1.09), Pro (1.12), Cha (1.89), .Arg (1.00) Example 18 H-Phenylalanyl-Lysyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Glycyl-Leucy1-DAlany1-Arginy1-OH FAB + MS: (M+H) + »844 Amino Acid Anal. : Phe (1.06), Lys (1.07), Cha (1.02), Gly (0.99), Leu (1.10), Ala (0.90), Arg (1.05) Example 19 HS (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2R/S)-m-Fluorophenylalanyl}- DPhenylalanyl-OH FAB+ MS: (M+H) + =870 Example 20 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2R/S)-m-Fluorophenylalanyl}- DPhenylalanyl-OH FAB+ MS: (M+H)+=870 Example 21 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{(2R)-2-Amino-3- cyclohexylpropanoyl}-Isoleucyl-DArginyl-OH FAB+ MS: (M+H)+=827 Amino Acid Anal. : PheMe (1.14), lie (0.99), Cha (1.00), Lys (0.92), Arg (1.09), Pro (1.12) Example 22 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-NH2 Example 266, N-Boc-(N-Methyl)Phenylalanyl-Lysyl(N- epsilon-Boc)-Prolyl-{ (2R)-2-.Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OCH 3f (100 mg, 0.1 mmol) " was placed in methanol (10 mL) saturated with ammonia in a sealed vessel. After 4 d, the mixture was evaporated to dryness. Removal of the Boc groups with 50% trifluoroacetic acid in methylene chloride furnished the crude material which was purified by HPLC as described in Example 2 to provide the title compound in 64% yield. FAB + MS: (M+H) + =956 Amino Acid Anal. : PheMe (0.83), Lys (0.99), Pro (1.02), Cha (1.85), Arg (0.99) Example 23 H-Lysyl-{ (2R/S)-2-Amino-5-phenylpentanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H)+-971 Example 24 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DNorleucyl-OH F.AB+ MS: (M+H) + -818 Example 25 H-(m-Fluoro)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DArginyl-OH FAB + MS: (M+H) + =865 Example 26 (N,N-Dimethyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DAxginyl-OH FAB + MS: (M+H) + -881 Example 27 H-Lysyl-Cysteinyl*-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2—Amino-3-cyclohexylpropanoyl}-DPenicillaminyl*- DAlanyl-Arginyl-OH FAB+ MS: (M+H) + =912 Example 28 H-Phenylalanyl-Lysyl-Arginyl- { (2R) -2-.Amino-3- cyclohexylpropanoyl }- ! (2S) -2-.Amino-3-cyclohexylpropanoyl } - DArginyl-OH FAB + MS : (M+H) + =913 .Amino Acid Anal . : Phe (0. 95) , Lys (1.05) , Cha (1. 92) , Arg (2.01) Example 29 H-Glycyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- Phenylalanyl-DArginyl-OH FAB+ MS: (M+H) + =757 Amino Acid Anal. : Gly (0.87), Phe (1.04), Cha (0.96), Lys (1.09), Arg (1.01), Pro (1.03) Example 30 (N-Isopropyl)Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =869 Example 31 N-Acetyl-Histidyl-Lysyl-Aspartyl-{(2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Arginyl-OH FAB + MS: (M+H)+=1016 Example 32 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalany1-{ (RS)-3- Fluorophenylalanyl}-OH -This compound was prepared in analogy to Example No. 322. FAB + MS: (M+H) + =870 Example 33 5\ (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2,3R/S)-2-Amino-3-phenylpropanoyl}- DArginyl-OH FAB+ MS: (M+H) + =875 Example 34 H-Arginyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+-862 Amino Acid Anal. : Pro (0.97), Cha (2.03), Lys (0.97), Arg (2.02) Example 35 H-Lysyl-Phenylalanyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-.Amino-3-cyclohexylpropanoyl}-Leucyl-DAlany1-Arginyl- OH FAB+ MS: (M+H) + »940 Amino Acid Anal. : Lys (1.00), Phe (0.99), Cha (1.92), Leu (1.04), Ala (0.99), Arg (0.99) Example 36 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Alanyl-DPhenylalanyl-OH FAB+ MS: (M+H) + «776 Amino Acid Anal. : Ala (0.99), PheMe (1.02), Phe (0.98), Cha (0.98), Lys (1.02), Pro (1.08) Example 37 H-Pheπylaianyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-DPhenylalanyl-DArginyl-OH FAB+ MS: (M+H) + »847 Amino Acid Anal. : Pro (1.05), Phe (1.92), Cha (1.03), Lys (0.96), Arg (1.04) Example 38 H-Lysyl-{ (2R/S)-2-Amino-5-phenylpentanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H) + =971 Example 39 (N-Methyl) henylalanyl-Lysyl-Tyrosyl-{ (2R)-2-Amino-3- cyclohex lpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =927 Amino Acid Anal.: PheMe (0.97), Lys (0.93), Tyr (0.99), Cha (0.96), Phe (1.00), Arg (1.02) Example 40 (N-Methyl)Phenylalany1-Lysyl-Glutamyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H) + =893 Example 41 H-DPhenylalanyl**-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl** This compound was prepared in analogy to Example 257. FAB+ MS: (M+H)+=835 .Amino Acid Anal.: Phe (0.95), Lys (1.00), Pro (1.14), Cha (2.04), Arg (1.02) Example 42 H-Lysyl-Cysteinyl*-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-Penicillaminyl*-DAlanyl- Arginyl-OH FAB + MS: (M+H)+=912 Example 43 H-Phenylalanyl-Lysyl-Prolyl-DLysyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH 5 ^ 5 FAB+ MS: (M+H) + -828 Amino Acid Anal. : Phe (0.96), Lys (2.02), Cha (1.84), Arg (1.03) Example 44 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DLeucyl-Leucy1-Arginyl-OH FAB+ MS: (M+H) + =787 Amino Acid Anal.: PheMe (0.97), Leu (2.01), Lys (0.98), Arg (0.87), Pro (1.10) Example 45 H-Phenylalanyl-Lysyl-{2-Aminocyclohexanecarbonyl}-{ (2R)-2- .Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+«881 Amino Acid Anal. : Phe (1.03), Lys (0.99), Cha (1.90), Arg (1.00) Example 46 N-Acetyl-Lysyl-Aspartyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl- OH FAB+ MS: (M+H)+=950 Example 47 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Tyrosyl(O-Ethyl)-DPhenylalanyl-OH FAB + MS: (M+H) + «896 Example 48 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DLeucyl-Phenylalany1- DArginyl-OH FAB+ MS: (M+H) + =821 J^mino Acid Anal.: PheMe (0.86), Leu (1.03), Phe (0.98), Lys (0.83), Arg (0.98), Pro (1.07) Example 49 H-DArginyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H) + =862 Amino Acid Anal. : Pro (0.93), Lys (1.03), Arg (2.03) Example 50 H-Phenylalanyl-Arginyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + *881 Amino Acid Anal.: Phe (0.96), Arg (2.05), Pro (1.02), Cha (1.96) Example 51 H-DLysyl-Phenylalanyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S) -2-Amino-3-cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl- OH FAB + MS: (M+H) + =940 Amino Acid Anal. : Lys (1.00), Phe (1.00), Cha (1.90), Leu (1.04), Ala (0.98), Arg (0.99) Ex-ample 52 (N-Methyl)Phenylalany1-Lysyl-Prolyl-DIsoleucyl-Phenylalanyl- DArginyl-OH FAB + MS: (M+H) + «821 Amino Acid Anal. : PheMe (1.29), lie (0.97),- Phe (0.98), Lys (0.99), Arg (1.06), Pro (1.06) Example 53 (N-Methyl)Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)- Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalany1- DArginyl-OH FAB+ MS: (M+H) + =957 s Example 54 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}' DArginyl-DArginyl-OH FAB+ MS: (M+H)+-983 Example 55 (N-Methyl) Phenylalanyl-Lysyl-Prolyl- { (2R) -2-Amino-3- cyclohexylpropanoyl }- (2-Naphthylalanyl) -DArginyl-OH FAB+ MS : (M+H) +-911 .Amino Acid Anal . : PheMe (0 . 95) , Cha (0. 92) , Lys (1 .08) , Arg (0 .90) , Pro (1 .14) Example 56 (N-Methyl)Phenylalanyl-Lysyl-Arginyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH FAB + MS: (M+H) + «926 Amino Acid Anal. : Phe (0.91), Lys (0.98), Cha (1.93), Arg (2.02) Example 57 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Arginyl-OH FAB + MS: (M+H)+=827 Example 58 H-Phenylalanyl-Lysyl-Lysyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =884 Amino Acid Anal. : Phe (0.96), Lys (2.02), Cha (1.84), Arg (1.03) St Example 59 (N-Methyl)Phenylalany1-!Lysyl(N,N-epsilon-dimethyl) }-Prolyl- { (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH Boc-DArg(N-guanidino-Tos)-Merrifield resin (0.5 g, 0.44 mmol/g substitution) was used to construct the peptide. Amino acids were attached to the resin sequentially in the following order: Boc-phenylalanine, Boc-(2R)-2-amino-3- cyclohexylpropanoic acid, Boc-proline, (N-alpha-Boc-N- epsilon-Fmoc)-lysine, and Boc-N-methylphenylalanine. After the last amino acid was attached, the sequence was stopped at agenda A-5. Boc-protected resin was washed with methylene chloride (3x10 mL) and DMF (3x10 mL) . After 20% piperidine in DMF (10 mL) was added and mixed for 30 min, the resin was washed with DMF (3x10 mL) and 30% formaldehyde aq. solution (0.2 mL, 2.5 mmol) in 0.1% acetic acid in DMF (10 mL) was added, followed by sodium cyanoborohydride (320 mg, 5 mmol) . The reaction was allowed to proceed at room temperature for 1 h. After the peptide resin obtained was washed with DMF (3x10 mL) and methylene chloride (3x10 mL) , the title compound was isolated by the method described in Example 2. FAB + MS: (M+H) + «889 Example 60 H-Phenylalanyl-Lysyl- {2-Amino-2-methy lpropanoyl}- ! (2R) -2- .Amino-3-cyclohexylpropanoy 1 } - 1 (2S) -2-Amino-3- cyclOahexylpropanoyl } -DArginyl-OH FAB+ MS : (M+H) + »841 Example 61 H-Lysyl-Alanyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2- Amino-3-cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H) + =864 Example 62 (N-Methyl) Phenylalanyl-Lysyl-Prolyl- ! (2R) -2-Amino-3- cyclohexy lpropanoyl } - {p-Nitro-phenylalanyl } -DPhenylalanyl-OH FAB + MS : (M+H) + -897 Example 63 (N-Methyl)Phenylalanyl-Lysyl-(l-Naphthylalanyl)-{ (2R)-2- Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + «961 Amino Acid Anal.: PheMe (0.94), Phe (0.97), Cha (0.94), Lys (1.00), Arg (1.03) Example 64 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2R)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-.Arginyl-OH FAB + MS: (M+H)+-940 Example 65 (N-Methyl)Phenylalanyl-{ (2S)-2-Amino-6-benzamidinyl- hexanoyl}-Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- Phenylalanyl-DArginyl-OH (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH*3 HOAc was prepared as described in Examples 1 and 2. The peptide was used without HPLC purification in the following reaction. This peptide (100 mg, 0.1 mmol) was dissolved in NaOH solution (I N, 0.5 mL) . The reaction mixture was diluted with acetone/water 2:1 (1.5 mL) and methylbenzimidate hydrochloride (60 mg, 0.35 mmol) was added. The reaction mixture was stirred at 50 °C overnight. The acetone was then removed in vacuo, the resulting aqueous solution acidified to sr pH 3 with trifluoroacetic acid, and acetonitrile added to dissolve any material that may oil out of the solution. The mixture is purified by HPLC by the method described in Example 2 to give the title compound (31 mg, 26% yield) . FAB+ MS: (M+H) + =964 Amino Acid Anal. : PheMe (0.99), Phe (0.94), Pro (1.03), Cha (1.05), Arg (1.03) Example 66 H-Phenylalanyl-Lysyl-Prolyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DArginy1-OH FAB + MS: (M+H)+=847 Amino Acid Anal. : Pro (0.96), Phe (2.16), Cha (0.91), Lys (0.97), Arg (1.00) Example 67 H-Lysyl-Phenylalanyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohex lpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =827 Example 68 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{ (2RS)-2-.Amino-3-methyl-3- phenylbutanoyl}-OEt Conjugate addition of phenylmagnesium bromide to diethyl isopropylidinemalonate gave diethyl (alpha, alpha- dimethylbenzyl)malonate in quantitative yield: Holmberg, C Liebigs Ann . Chim. 1981, 748-760. Monohydrolysis (Plattner, J. J.; Marcotte, P. A.; Kleinert, H. D.; Stein, H. H.; Greer, J.; Bolis, G.; Fung, A. K.; Bopp, B. A.; Luly, J. R.; Sham, H. L.; Kempf, D. J.; Rosenberg, S. H.; Dellaria, J. F.; De, B.; Merits, I.; Perun, T. J. J. Med. Chem. 1988, 31, 2277- 2288.) followed by Curtius rearangement (Shioiri, T.; sη Ninomiya, K.; Yamada, S. J. Am. Chem. Soc. 1972, 54, 6203.) produced N-Boc-(R/S)-beta,beta-dimethylphenylalanine ethyl ester in 15% yield: 1H NMR (CDC13, 300 MHz) S 1.0 (t, 3 H), 1.39 (s, 3 H), 1.4 (s, 9 H) , 1.43 (s, 3 H) , 3.94 (q, 2 H) , 4.52 (d, 1 H), 5.06 (d, 1 H) , 7.22 (m, 1 H) , 7.32 (m, 4 H) ; mass spectrum, m/e 322(M+H) . Afer removal of the Boc group with 4 M hydrochloric acid in dioxane, the amino ester was coupled to N-Boc(N-Methyl)Phenylalanyl-Lysyl(N-epsilon-Boc)- Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl-OH (Prepared as described in Example 322) with 1-(3-dimethyl- aminopropyl)-3-ethyl carbodiimide hydrochloride. The Boc groups were cleaved with methylene chloride-trifluoroacetic acid (1:1). HPLC, carried out as described in Example 2 provided the inseparable diastereomeric pair in a 35% combined yield. FAB + MS: (M+H) + »908 Amino Acid Anal.: PheMe (1.02), Lys (1.01), Pro (0.99), Cha (0.99), Phe (1.00) Example 69 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- ! (2R/S)-2-Amino-3-methyl-3-phenylbutanoyl}-OEt This compound was prepared in analogy to Example 68. The diastereomeric pair. Examples 69 and 83, were separable by HPLC. " FAB + MS: -<M+H) + »914 Amino Acid Anal.: PheMe (0.95), Lys (0.99), Pro (1.01), Cha (1.92) Example 70 (N-Methyl)Phenylalanyl-Citrullyl-Prolyl-DPhenylalanyl-! (2S)- 2-Amino-3-cyclohexylpropanoyl}-D.Arginyl-OH FAB + MS: (M+H) + »890 Amino Acid Anal. : PheMe (0.90), Phe (1.04), Cha (0.91), Cit (1.06), Arg (1.06), Pro (1.03) Example 71 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl-{ (2R) 2-.Amino-3-cyclohexylpropanoyl}-Arginyl-DArginyl-OH FAB + MS: (M+H) + *952 Amino Acid Anal. : Phe (1.06), Lys (1.08), Cha (0.97), Pro (0.92), Arg (2.00) Example 72 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Glycyl-D.Arginyl-OH FAB+ MS: (M+H) + =731 Example 73 H-Lysyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohex lpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H) + =834 Amino Acid Anal.: Lys (1.98), Pro (1.10), Cha (1.85), Arg (1.02) Example 74 (N-Methyl)Phenylalanyl-Glycyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H) + =790 Example 75 H-Phenylalanyl-Lysyl-DProlyl-{ (2S)-2-.Amino-3- cyclohexylpropanoyl}-Leucy1-DAlanyl-Arginyl-OH FAB + MS: (M+H) + =884 Example 76 ( l (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{p-Amino-phenylalanyl}-DPhenylalanyl-OH FAB+ MS: (M+H) + «=866 Example 77 H-Phenylalanyl-DLysyl-I2-Amino-2-methylpropanoyl}-! (2R)-2- Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =835 Example 78 H-Phenylalanyl-Lysyl-Prolyl-DValyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H) + =799 Amino Acid Anal. : Phe (0.98), Lys (0.98), Pro (1.06), Val (0.93), Cha (1.01), Arg (1.04) Example 79 H-Phenylalanyl-Lysyl-Alanyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Arginyl-OH FAB + MS: (M+H) + *940 Example 80 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DTryptophanyl-OH FAB + MS: (M+H) + -891 Example 81 H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-Arginyl-OH FAB + MS: (M+H) + =847 Amino Acid Anal.: Pro (1.10), Phe (1.88), Cha (1.06), Lys (0.87), Arg (1.09) k>2 Example 82 H-DHistidyl-Lysyl-Alanyl-{ (2S)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArginyl-OH FAB+ MS: (M+H)+=930 Example 83 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- {(2R/S)-2-Amino-3-methyl-3-phenylbutanoyl}-OEt The title compound was prepared as described in Example 69. FAB + MS: (M+H) + *914 Amino Acid Anal.: PheMe (0.66), Lys (1.01), Pro (0.99), Cha (1.94) Example 84 (N-Methyl)Phenylalanyl-{ (2S)2-Amino-6-ureido-hexanoyl}- Prolyl-DPhenylalanyl-{ (2S)-2-.Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH FAB + MS: (M+H) + =904 Amino Acid Anal. : PheMe (0.91), Phe (1.07), Cha (0.93), hCit (0.98), Arg (1.06), Pro (1.04) Example 85 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl- D-Arginyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H) + -952 Amino Acid Anal. : Pro (1.05), Phe (0.96), Lys (0.95), Arg (2.03) Example 86 H-Phenylalanyl-Lysyl-Alany1-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-DArginyl-OH F.AB + MS: (M+H) + =858 Example 87 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DAspartyl-Phenylalanyl- DArginyl-OH FAB + MS: (M+H)+-823 Amino Acid Anal. : PheMe (0.99), Lys (0.92), Pro (0.95), Asx (1.04), Phe (1.05), Arg (1.06) Example 88 (N-Methyl)Phenylalany1-Glutamyl-Prolyl-l (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS : (M+H)+=862 Example 89 (N,N-Diallyl)Phenylalanyl-Lysyl-Alanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + -907 Example 90 H-Phenylalanyl-Lysyl-Alanyl-1 (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DProlyl-Arginyl-OH FAB + MS: (M+H) + »884 Amino Acid Anal.: Phe (0.99), Lys (1.07), Ala (0.92), Cha (1.24), Leu (1.04), Pro (0.97), Arg (1.16) Example 91 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-!2-Aminoindan-2-carbonyl}-DPhenylalanyl- OH The following literature procedure was used to prepare 2-aminoindan-2-carboxylic acid: Pinder, R. M.; Butcher, B. CM H.; Buxton, D. A.; Howells, D. J. J. Med. Chem. 1971, 14, 892. FAB+ MS: (M+H) + =864 Example 92 N-Acetyl-! (IR/S) (2R/S) ((Z)-l-Amino-2-ρhenylcyclopropyl)-1- carbonyl}-Lysyl-Alanyl-! (2R)-2-Amino-3- cyclohexy lpropanoyl }- ! (2S) -2-Amino-3-cyclohexy lpropanoyl }- .Arginyl-OH The C-terminal pentapeptide is prepared under standard solid phase peptide synthesis conditions. The epsilon nitrogen of lysine is protected as its Fmoc derivative which remains intact during the acidic cleavage of the pentapeptide from the resin. Racemic ( (Z)-l-Acetamido-2- phenylcyclopropane)-l-carboxylic acid is prepared from Z- acetamidocinnamic acid according to the methodology given in, Schmidt, ϋ.; Lieberknecht, A.; Wild, J. Synthesis 1988, 159- 172, and the references cited therein. This amino acid is then coupled in solution phase to the pentapeptide by the mixed acid anhydride method, and the Fmoc group is removed with piperidine. Separation of the diastereomeric products by HPLC furnishes the final product. Example 93 H-Phenylalanyl-Lysyl- !2-.Amino-2-methy lpropanoyl }- ! (2R) -2- Amino-3-cyclohexy lpropanoyl } -Phenylalanyl-DArginyl-OH FAB+ MS : (M+H) +=835 Example 94 H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DOrnithyl-OH FAB + MS: (M+H) + »811 Amino Acid Anal. : Pro (1.01), Phe (0.98), Cha (1.99), Lys (1.02) Example 95 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-.Amino-3- cyclohexylpropanoyl}-Leucyl-Arginyl-OH FAB + MS: (M+H) + *787 Example 96 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DTryptophanyl-OH FAB+ MS: (M+H)+=897 Example 97 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-N-(Methyl) (Benzyl) This compound was prepared in analogy to Example 3. FAB+ MS: (M+H) + =970 .Amino Acid Anal. : PheMe (0.83), Lys (1.00), Pro (1.02), Cha (1.90), Arg (0.98) Example 98 H-Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DLeucyl-DArginyl-OH FAB+ MS: (M+H)+-940 Example 99 H-Arginyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino- 3-cyclohexylpropanoyl}-Alanyl-DLysyl-DPhenylalanyl-OH FAB + MS: (M+H) + =827 a Example 100 (N-Methyl)Phenylalany1-Lysyl-Prolyl-DPhenylglycyl-Alanyl- DArginyl-OH FAB + MS: (M+H) + =765 Amino Acid Anal.: Ala (0.58), Phg (0.91), PheMe (0.94), Lys (0.97), Arg (1.03), Pro (1.04) Example 101 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl-{ (2R) 2-Amino-3-cyclohexylpropanoyl}-Glutamyl-DArginyl-OH F.AB+ MS: (M+H) + =925 .Amino Acid Anal. : Glu (0.90), Pro (1.00), Phe (0.98), Cha (1.02), Lys (1.00), Arg (1.09) Example 102 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DLeucyl-DArginyl-OH FAB + MS: (M+H)+=940 Example 103 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DtLeucyl-Phenylalanyl- DArginyl-OH FAB + MS: (M+H) + =821 Amino Acid Anal.: PheMe (1.34), Lys (0.97), Pro (0.93), Phe (1.01), Arg (1.03) Example 104 H-Leucyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}- Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =813 Amino Acid Anal.: Pro (0.95), Leu (1.10), Phe (1.05), Cha (0.90), Lys (0.95), Arg (1.04) Example 105 H-{ (3R/S)-l,2,3,4-Tetrahydroisoquinolin-3-carbonyl}-Lysyl- Alanyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H) + *839 Example 106 H-{ (3R/S)-1,2,3,4-Tetrahydroisoquinolin-3-carbonyl}-Lysyl- Alanyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H) + =839 Example 107 H-(p-Iodo)Phenylalanyl-Lysyl-1 (2S)-2-A.mino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H) + «=1066.Amino Acid Anal.: Lys (0.72), Cha (1.99), Leu (1.00), Ala (1.29), Arg (1.05) Example 108 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{2-Aminoindan-2-carbonyl}-DArginyl-OH The following literature procedure was used to prepare 2-aminoindan-2-carboxylic acid: Pinder, R. M.; Butcher, B. H.; Buxton, D. A.; Howells, D. J. J. Med. Chem. 1971, 14, 892. F.AB+ MS: (M+H) + =873 Example 109 H-Phenylalanyl-Lysyl-Prolyl-DGlutamyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H) + =929 (el Example 110 H-Phenylalanyl-Ornithyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =839 Amino Acid Anal.: Pro (1.04), Ph (1.03), Cha (1.94), Arg (0.98) Example 111 H-Phenylalanyl-Lysyl-Alanyl-{(2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArginyl-OH FAB + MS: (M+H) + =940 Example 112 (N-Methyl)Phenylalanyl-Lysyl-Lysyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =892 Amino Acid Anal.: PheMe (0.93), Phe (0.96), Cha (0.93), Lys (2.01), Arg (1.03) Example 113 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-NH(Phenethyl) This compound was prepared in analogy to Example 3. FAB + MS: (M+H) + =970 Amino Acid Anal. : PheMe (0.88), Lys (0.99), Pro (1.00), Cha (1.88), Arg (1.01) Example 114 H-Phenylalanyl-Lysyl-DAlanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DLeucyl-D.Arginyl-OH FAB + .MS: (M+H) + =940 ( c-\ Example 115 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-D(2-Naphthylalanyl)- Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=905 Example 116 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl- DGlutaminyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H) + =924 Amino Acid Anal.: Gin (1.09), Pro (0.97), Phe (0.95), Lys (0.94), Arg (1.05) Example 117 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DLeucyl-Arginyl-OH F.AB+ MS: (M+H) + *787 Example 118 H-Phenylalanyl-Lysyl-Phenylalanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H) + =903 Amino Acid Anal.: Phe (2.00), Lys (0.98), Cha (1.89), Arg (1.02) Example 119 H-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Arginyl-DArginy1-OH FAB + MS: (M+H) + «856 Amino Acid Anal. : Phe (0.97), Cha (0.93), Lys (1.03), Arg (1.98), Pro (1.02) Example 120 N-Acetyl-Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH The trifluoroacetic acid salt of Phenylalanyl-Lysyl(N- epsilon-Cbz)-Alanyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-cyclohexylpropanoyl}-DArgininyl(N-guanidino- Tos)-OResin (0.26 g) was prepared according to the procedure described in Example 1. The peptide-resin obtained was washed with 10%-diisopropylethylamine (DIEA) in methylene chloride (3 x 15 mL, 45 seconds each) and methylene chloride (4 x 15 mL) . 10%-DIEA in methylene chloride (30 mL) was introduced into the reaction vessel and acetic anhydride (2 mL) was added. It was reacted at room temperature for 40 min. The N-acetyl-peptide-resin was treated with HF and anisole, was purified by HPLC, according to the procedure mentioned in Example 2 to yield 12 mg of pure product consistent with proposed structure. FAB + MS: (M+H)+=869 Example 121 H-(4-Methyl)Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H) + =872 Example 122 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-{2- Aminoindan-2-carboxoyl}-OH The following literature procedure was used to prepare 2-aminoindan-2-carboxylic acid: Pinder, R. M.; Butcher, B. H.; Buxton, D. A.; Howells, D. J. J. Med. Chem. 1971, 14, 892. 11 This peptide was prepared in analogy to Example No. 322. TAB* MS: (M+H) + «870 Example 123 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-(1-Naphthylalany1)-DArginyl-OH FAB+ MS: (M+H)+=911 .Amino Acid Anal.: PheMe (0.94), Cha (0.92), Lys (0.98), Arg (1.02), Pro (1.00) Example 124 H-Phenylalanyl-Lysyl-Prolyl-DLeucyl-! (2S)-2-.Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB + MS:. (M+H) + «813 Amino Acid Anal.: Pro (1.21), Leu (1.18), Phe (0.89), Cha (0.90), Lys (0.80), Arg (1.01) Example 125 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DPhenylalanyl-Arginyl-OH FAB+ MS: (M+H) + »991 Amino Acid Anal. : Phe (1.95), Lys (0.99), Ala (1.02), Cha (1.04), Leu (1.07), Arg (1.05) Example 126 H-! (2R)-2-Amino-4-phenylbutanoyl}-Lysyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DAlanyl-Arginyl-OH FAB+ MS: (M+H)+=954 Example 127 H-( (2S)-2-.Amino-4-phenylbutanoyl}-Lysyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DAlanyl-Arginyl-OH F.AB+ MS: (M+H) + *954 Example 128 (N-Methyl) henylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =861 Amino Acid Anal. : PheMe (0.77), Phe (0.97), Cha (0.94), Lys (0.81), Arg (1.02), Pro (1.02) Example 129 H-Phenylalanyl-Lysyl-Phenylalanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucy1-Arginyl-OH FAB + MS: (M+H) + =863 Example 130 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-( (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2R/S)-2-Amino-3-methyl-3-phenylbutanoyl}-OH N-Boc-(R/S)-beta,beta-dimethylphenylalanine ethyl ester (100 mg, 0.3 mmol) was hydrolyzed overnight with lithium hydroxide monohydrate (20 mg, 0.5 mmol) in dioxane- water (2:1, 3 mL) at 70 °C to obtain N-Boc-(R/S)-beta,beta- dimethylphenylalanine in quantitative yield. The Boc group was removed with 4 M HCl-dioxane, and the product was coupled to N-Boc-(N-Methyl)Phenylalanyl-Lysyl-Prolyl-1 (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohex lpropanoyl}-OH as described in Example 322. Removal of the Boc groups and separation/purification of the diastereomeric pair was accomplished as described in Example 322 to supply a combined yield of 45%. FAB+ MS: (M+H) + =886 Amino Acid Anal. : PheMe (0.75), Lys (1.01), Pro (0.99), Cha (1.99) Example 131 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- ! (2R/S)-2-.Amino-3-methyl-3-phenylbutanoyl}-OH This compounds was prepared as described in Example 130. F.AB+ MS: (M+H)+-886 Amino Acid Anal.: PheMe (0.71), Lys (1.00), Pro (1.00), Cha (1.98) .Example 132 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! <2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-! (S)-Phenylglycinyl}-OH The title compound was prepared in analogy to Example 352. FAB + MS: (M+H)+-838 Amino Acid Anal. : PheMe (0.74), Lys (0.99), Pro (1.05), Cha (0.98), Phe (0.97) Example 133 H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+-847 Amino Acid Anal. : Pro (1.10), Phe (2.00), Cha (0.92), Lys (0.93), Arg (0.99) Example 134 H-Penicillaminyl*-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucy1-DCysteiny1*-Arginy1-OH FAB + MS: (M+H)+-872 Example 135 H-Phenylalanyl-Lysyl-Glycyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=807 ->M Example 136 (N-Methyl) henylalanyl-Lysyl-Prolyl-DTyrosyl-{ (2S)-2-Amino-3- cyclohexylpropano l}-DArginyl-OH FAB+ MS: (M+H)+=877 Amino Acid Anal. : Pro (1.13), PheMe (0.98), Tyr (1.02), Cha (0.94), Lys (1.00), Arg (0.92) Example 137 H-DPhenylalanyl-Lysyl-Alanyl- { (2R) -2-Amino-3- cyclohexylpropanoyl }- { (2S) -2-Amino-3-cyclohexy lpropanoyl }- DArginyl-OH FAB+ MS : (M+H) + =827 Example 138 H-Phenylalany1-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Arginyl-OH FAB+ MS : (M+H) + =940 Amino Acid Anal. : Phe (0.99), Lys (0.99), Ala (0.91), Cha (1.90), Leu (1.03), Arg (1.00) Example 139 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{2-.Aminoindan-2-carbonyl}- OH The following literature procedure was used to prepare 2-aminoindan-2-carboxylic acid: Pinder, R. M.; Butcher, B. H.; Buxton, D. A.; Howells, D. J. J. Med. Chem. 1971, 14, 892. This peptide was prepared in analogy to Example No. 322. FAB+ MS: (M+H)+=864 Example 140 s (N-Methyl) Phenylalanyl-Lysyl-Prolyl-D (1-Naphthy lalanyl) - (1- Naphthylalanyl) -DArginyl-OH FAB+ MS : (M+H) +=955 Example 141 H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Valyl-DArginyl-OH FAB+ MS: (M+H)+=799 Amino Acid Anal. : Pro (1.05), Val (0.98), Phe (0.87), Cha (0.76), Lys (0.78), Arg (0.84) Example 142 H-! (2R/S)-2-Amino-5-phenylpentanoyl}-Lysyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H) + =968 Amino Acid Anal. : hhPhe (0.64), Lys (1.03), Cha (2.03), Leu (1.03), Ala (0.93), Arg (1.01) Example 143 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- ! (R/S)-2-Methyl-arginyl}-OH (R/S)-(N-delta-Cbz)-2-methyl-ornithine benzyl ester was prepared in analogy to the compound prepared for the synthesis of Example 378: lH NMR (CDC13, 300 MHz) 5 1.34 (s, 3 H), 1.5-1.7 ( , 4 H), 3.15 (q, 2 H), 4.77( b, 1 H) , 5.1 (s, 2 H) , 5.15 (d, 2 H) , 7.35 (m, 10 H) ; mass spectrum, m/e 371(M+H) . The title compound was obtained using the methodology reported for Example 378. FAB + MS: (M+H) + =881 Amino Acid Anal.: PheMe (0.80), Lys (1.00), Pro (1.00), Cha (1.87) Example 144 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-.Amino-3-cyclohexylpropanoyl}- {(R/S)-2-Methyl-arginyl}-0H This compound was prepared using the methodology reported for Example 143. FAB+ MS: (M+H)+=881 Amino Acid Anal.: PheMe (0.80), Lys (1.04), Pro (0.96), Cha (1.89) Example 145 (N-Methyl) (p-Nitro)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoy1}- DArginyl-OH FAB + MS: (M+H)+=912 Amino Acid Anal. : Lys (0.69), Pro (1.12), Cha (1.92), Arg (1.00) Example 146 H-Histidyl-Lysyl-Alanyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl-DArginyl-OH FAB + MS: (M+H)+=930 Example 147 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DAlanyl-OH FAB+ MS: (M+H)+=776 Amino Acid Anal.: Ala (1.07), PheMe (0.98), Phe (1.01), Cha (0.96), Lys (0.97), Pro (1.03) Example 148 H-Phenylalany1-Lysyl-Leucy1-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH FAB+ MS: (M+H)+=869 Amino Acid Anal.: Leu (1.01), Phe (0.96), Cha (2.00), Lys (0.98), Arg (1.05) Example 149 H-Phenylalanyl-Lysyl-DPenicillaminyl*-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DCysteinyl*-Arginyl-OH FAB + MS: (M+H) + =948 Example 150 (N-Methyl)Phenylalanyl-Phenylalanyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-.Amino-3- cyclohexylpropanoyl}DArginyl-OH FAB + MS: (M+H) + =886 Amino Acid Anal. : PheMe (1.30), Phe (0.91), Pro (1.08), Cha (1.96), Arg (1.01) Example 151 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-Arginyl-OH FAB+ MS: (M+H)+»861 Amino Acid Anal.: Pro (1.15), PheMe (1.13), Phe (1.04), Cha (0.83), Lys (0.96), Arg (1.04) Example 152 (N-Methyl)Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =841 Example 153 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH FAB + MS: (M+H)+=855 Example 154 76 H-Alanyl-Phenylalanyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoy1}- DArginyl-OH FAB+ MS: (M+H)+=796 Example 155 (N-Methyl)Phenylalanyl-Lysyl-{ (2R/S)-2-Amino-5- phenylpentanoyl}-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- Phenylalany1-DArginy1-OH FAB+ MS: (M+H)+=939 Amino Acid Anal. : PheMe (1.02), Phe (0.94), Cha (0.99), Lys (1.01), Arg (1.05) Example 156 (N-Methyl)Phenylglycyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohex lpropanoyl}-( (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=853 Amino Acid Anal. : Lys (0.96), Pro (1.12), Cha (1.99), Arg (1.04) Example 157 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DLysyl-Phenylalanyl- DArginyl-OH FAB+ MS: (M+H)+=836 Amino Acid Anal. : PheMe (1.30), Phe (0.98), Lys (2.00), Arg (1.09), Pro (0.93) Example 158 (N-Methyl)Phenylalanyl-Lysyl(N-epsilon-fo.rmyl)-Prolyl-1 (2R) • 2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohex lpropanoyl}-DArginyl-OH FAB+ MS: (M+H) + =895 Amino Acid Anal. : PheMe (0.92), Lys (0.99), Pro (1.13), Cha (1.92), Arg (1.01) 7? Example 159 H-Phenylalanyl-Lysyl-Phenylalanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H) + =903 Example 160 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{ (2R/S)-2-.Amino-3-methyl-3 phenylbutanoyl}-OH This compound was prepared in analogy to Example 130. FAB+ MS: (M+H)+-880 Amino Acid Anal. : PheMe (0.72), Lys (1.01), Pro (0.98), Cha (0.99), Phe (1.01) Example 161 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{ (2R/S)-2-Amino-3-methyl-3 phenylbutanoyl}-OH This compound was prepared as described in Example 160. FAB+ MS: (M+H)+=880 Amino Acid Anal.: PheMe (0.76), Lys (1.00), Pro (0.98), Cha (1.00), Phe (1.02) Example 162 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-Glycyl-OH FAB+ MS: (M+H)+=762 Amino Acid Anal.: Gly (1.04), PheMe (1.02), Phe (0.95), Cha (0.97), Lys (0.91), Pro (1.11) Example 163 H-Phenylalanyl-Lysyl-Prolyl-DPhenylalanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+=847 Amino Acid Anal.: Pro (1.00), Phe (1.92), Cha (1.03), Lys (0.95), Arg (1.09) Example 164 H-DPenicillaminyl*-Lysyl-Alanyl-{(2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DCysteinyl*-Arginyl-OH FAB+ MS: (M+H) + =872 Example 165 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{(2R)-2-Amino-3- cyclohex lpropanoyl}-Tryptophanyl-DArginyl-OH FAB+ MS: (M+H)+=900 Amino Acid Anal.: Pro (1.11), PheMe (1.02), Cha (1.04), Lys (0.84), Trp (0.84), Arg (1.15) Example 166 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=867 Example 167 H-Phenylalanyl-Aspartyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DAlanyl-Arg FAB+ MS: (M+H) + =927 Example 168 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-Tyros l(O-Methyl)-DPhenylalanyl-OH FAB+ MS: (M+H)+=882 Example 169 (N-Methyl)Phenylalany1-Lysyl-Prolyl-DArginyl-Phenylalanyl- DArginyl-OH FAB+ MS: (M+H)+=864 Amino Acid Anal. : PheMe (1.03), Phe (1.00), Lys (0.93), Arg (2.07), Pro (0.89) Example 170 (N-Methyl)Tyrosyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH FAB + MS: (M+H)+=883 Amino Acid Anal. : Lys (0.93), Pro (1.10), Cha (1.99), Arg (1.07) Example 171 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Lysyl-OH FAB+ MS: (M+H)+=912 Example 172 (N-Methyl)Phenylalanyl-Lysyl-Arginyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=920 Amino Acid Anal. : PheMe (1.04), Phe (0.95), Cha (0.95), Lys (0.99), Arg (2.06) Example 173 (N-Methyl)Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)- Prolyl-DPhenylalanyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=957 Amino Acid Anal.: Pro (0.98) PheMe (0.90), Phe (1.00), Cha (1.04), Lys (1.00), Arg (1.07) Example 174 H-Lysyl-Phenylalanyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H) + =827 Example 175 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{ (R/S)-t-Butylalanyl}-OH This peptide was constructed as described in Example No. 322. FAB+ MS: (M+H)+=832 Amino Acid Anal. : PheMe (1.06), Phe (0.96), Lys (0.99), Pro (1.04), Cha (0.83), t-butylAla (1.03) Example 176 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{ (R/S)-t-Butylalanyl}-OH This peptide was prepared in analogy to Example No. 322. FAB+ MS: (M+H)+=832 Amino Acid Anal. : PheMe (1.08), Phe (0.91), Lys (0.94), Pro (0.99), Cha (0.77), t-butylAla (0.97) Example 177 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Tyrosyl(O-Me)-DArginyl-OH FAB+ MS: (M+H)+=905 Example 178 H-Phen lalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-DProlyl-DArginyl-OH FAB+ MS: (M+H)+=797 Example 179 S3 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DArginyl-OH FAB+ MS: (M+H) + =787 Example 180 (N-Methyl)Phenylalanyl-Lysyl-Arginyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DPhenylalanyl-OH FAB+ MS: (M+H)+=911 Example 181 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-Phenylalanyl-OH FAB+ MS: (M+H)+=852 Amino Acid Anal.: Phe (2.07), Cha (0.88), Lys (0.99), Pro (1.06) Example 182 N-Acetyl-! (Z)-2-Amino-3-phenyl-2-propenoyl}-Lysyl-Prolyl- ! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl- OH The C-terminal pentapeptide is prepared using standar solid phase peptide synthesis techniques. The lysine is incorporated with the epsilon nitrogen protected with Fmoc which survives HF cleavage of the peptide from the resin an removal of the other protecting groups. Z-Acetamidocinnami acid is coupled to the pentapeptide in solution phase employing the mixed acid anhydride method. The Fmoc group subsequently removed with piperidine, and the crude peptide is purified by HPLC. Example 183 (N-Methyl)Alanyl-Lysyl-Prolyl-{(2R)-2-Amino-3- cyclohex lpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =791 Amino Acid Anal. : Lys (0.87), Pro (1-12), Cha (2.01), Arg (1.01) Example 184 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-.Amino-3-cyclohexylpropanoyl}- DAlanyl-Arginyl-OH FAB+ MS: (M+H)+=898 Example 185 (N-Methyl)Phenylalanyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+=892 Example 186 (N-Methyl)Phenylalanyl-Lysyl-{ (2S)-2-Amino-4-phenylbutanoyl}- ! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=925 Amino Acid Anal.: PheMe (1.01), Phe (0.99), Cha/hPhe (1.92), Lys (1.00), Arg (1.01) Example 187 (N-Methyl)Phenylalany1-Norleucyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH FAB + MS: (M+H) + =852 Amino Acid Anal.: Nle (0.95), Pro (1.07), Cha (1.85), Arg (0.98) Example 188 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2R)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArginyl-OH FAB + MS: (M+H)+-940 Example 189 (N-Methyl)Phenylalanyl-Arginyl-Prolyl-f (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+-889 Amino Acid Anal. : PheMe (1.05), Phe (0.97), Cha (0.97), Arg (1.96), Pro (1.07) Example 190 (N-Methyl)Phenylalany1-Lysyl-Glycyl-l (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H)+=821 Amino Acid Anal. : Gly (1.02), PheMe (1.07), Phe (1.07), Cha (0.84), Lys (0.94), Arg (1.06) Example 191 H-DPhenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArginyl-OH FAB+ MS: (M+H)+=940 Example 192 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-1 (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-! (2RS)-2-Amino-2-methyl-3- phenylpropanoyl}-OH (2RS)-2-Amino-2-methyl-3-phenylpropanoic acid was coupled to Boc-(N-methyl)phenylalanyl-lysyl(N-epsilon-Boc)- prolyl-! (2R)-2-amino-3-cyclohexylpropanoyl}-phenylalany1-OH as described in Example 322. Deprotection and HPLC gt purification also as described in the same example provided the title compound in 33% yield. FAB+ MS: (M+H)+=866 Amino Acid Anal.: PheMe (0.85), Lys (0.95), Pro (1.00), Cha (0.96), Phe (1.05) Example 193 (N-Methyl)Phenylalanyl-Lysyl(N-epsilon-nicotynyl)-Prolyl- { (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH The protected peptide resin; Boc-(N- Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl(N-guanidino-Tos)- O-resin was synthesized by the method described in Example No. 59. The N-epsilon-amino group of the lysyl residue was coupled with nicotinic acid (10 molar equivalents) in the presence of diisopropylcarbodiimide (DIPCDI) (10 molar equivalents) in DMF (15 mL) at room temperature for 5 h. The resin obtained was washed with DMF (3x10 mL) and methylene chloride (3x10 mL) , and the title compound was obtained by the method described in Example 2. FAB + MS: (M+H) + »966 .Example 194 H-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- .Arginyl-OH FAB+ MS: (M+H)+=853 Example 195 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DLeucyl-Arginyl-OH FAB + MS: (M+H) + =940 Example 196 H- ! (2S) -2-Amino-3-cyclohexylρropanoyl }-Lysyl-Prolyl- ! (2R) -2- .Amino-3-cyclohexylpropanoyl }- ! (2S) -2-.Amino-3- cyclohexylpropanoyl } -DArginyl-OH FAB+ .MS : (M+H) + »859 Example 197 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Phenylalanyl-OH FAB+ MS: (M+H)+=858 Amino Acid Anal.: PheMe (0.91), Phe (1.19), Lys (0.97), Pro (0.91) Example 198 (N-Methyl)Leucyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =833 Amino Acid Anal.: Lys (0.96), Pro (1.04), Cha (1.97), Arg (1.01) .Example 199 H-Phenylalanyl-Lysyl-Phenylalanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DArginyl-OH FAB+ MS: (M+H)+-863 Example 200 H-Phenylalanyl-Lysyl(epsilon-N**)-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-! (2S)-2-Amino-3-cyclohexylpropanoyl}** The peptide H-Phenylalanyl-Lysyl(epsilon-N[2-C1-Z])- Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl(N-guanidino-Tos)-{ (2S)-2-Amino- 3-cyclohexylpropanoyl}-0-Resin was prepared by the methods presented in Examples 1 and 2. The peptide-resin (0.76 mmol) was suspended in dry dimethylformamide (6 mL) under nitrogen then ethyl trifluoroacetate (0.6 mL, 7.6 mmol) and triethylamine (0.7 mL, 7.6 mmol) were added. The suspension was stirred gently overnight, the resin removed by filtration, washed with several portions of methylene chloride, and dried by aspiration. The peptide was then cleaved from the resin and purified by HPLC as described in Example 2. The resulting peptide (134 mg, 0.11 mmol) was dissolved in 40% aqueous acetonitrile (30 mL) ; 1 N hydro¬ chloric acid (0.5 mL) was added and the mixture was lyophilized to give the hydrochloride salt of the peptide. The resulting white powder was dissolved in dry dimethylformamide (12 mL) at -20 °C under nitrogen. Diphenylphosphoryl azide (25.8 uL, 0.12 mmol) was added followed by triethylamine (70 uL, 0.5 mmol). The mixture was stored in a freezer at -15 °C for 12 d. The dimethylformamide was then removed in vacuo . The resulting oil was purified by HPLC as described in Example 2. The peptide (21.4 mg) was dissolved in methanol (0.9 mL) and water (0.9 mL) and saturated aqueous sodium carbonate solution (0.4 mL) was added. The mixture was stirred overnight at room temperature, then purified by HPLC to supply the title compound (6 mg, 5% ) . FAB+ MS: (M+H)+=988 Example 201 H-Phenylalany1-Lysyl-Prolyl-DGlutaminyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+-828 Amino Acid Anal.: Glx (1.05), Phe (0.96), Cha (0.93), Lys (1.01), Arg (0.99), Pro (1.13) Example 202 9-Fluorenylmethyloxycarbonyl-Phenylalanyl-Lysyl-Prolyl-! (2R) 2-Amino-3-cyclohexylpropanoyl}-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H)+=1075.Amino Acid Anal.: Phe (0.97), Lys (0.99), Pro (1.19), Cha (1.99), Arg (1.04) Example 203 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArginyl-NHNH2 FAB + MS: (M+H)+=954 .Example 204 (N-Methyl)Phenylalanyl-Phenylalanyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=880 Amino Acid Anal.: PheMe (1.11), Phe (1.84), Cha (0.99), Arg (1.08), Pro (1.08) Example 205 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R/S)-2-Amino-5- phenylpentanoy1}-Alany1-DArginy1-OH FAB+ MS: (M+H)+=807 Amino Acid Anal.: Pro (1.15), Ala (0.78), PheMe (0.99), Lys (0.92), Arg (1.15) Example 206 H-Phenylalanyl-DLysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArginyl-OH F.AB + MS: (M+H) + =940 Example 207 (N-Methyl)Phenylalanyl-Lysyl-Arginyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH FAB+ MS : (M+H)+=842 .Amino Acid Anal. : Ala (0.99), PheMe (1.03), Cha (1.95), Lys (0.99), Arg (1.02) Example 208 (2R)-2-Amino-3-cyclohexylpropanoyl}**-Phenylalanyl-Lysyl- Alanyl-DArginyl-Phenylalanyl** This compound was prepared in analogy to Example 257. FAB + MS: (M+H) + =803 Example 209 H-Arginyl-Phenylalany1-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=1009 Amino Acid Anal. : Pro (0.95), Phe (0.94), Cha (2.03), Lys (0.96), Arg (2.12) Example 210 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DLeucyl-DArginyl-OH FAB + MS: (M+H) + =787 Example 211 (N-Methyl) Pheny lalany 1-Lysyl-Proly l- { (2R) -2-Amino-3- cyclohexylpropanoyl } -DPhenylalanyl-DPhenylalanyl-OH FAB + MS : (M+H) +=852 q» Example 212 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phen lalanyl-DPhenylalanyl-OH FAB+ MS: (M+H)+-852 Amino Acid Anal.: PheMe (0.94), Phe (2.09), Cha (0.89), Lys (0.99), Pro (1.09) Example 213 H-Histidyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}- ! (2S)-2-Amino-3-cyclohex lpropanoyl}-DArginyl-OH FAB+ MS : (M+H)+-843 .Amino Acid Anal.: His/Cha (2.89), Lys (0.99), Pro (1.01), Arg (1.00) Example 214 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArg FAB + MS : (M+H) + =940 Example 215 (N-Methyl)Phenylalany1-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl- DArginyl-OH FAB+ MS: (M+H)+-886 Example 216 (N-Methyl)Phenylalany1-Lysyl-Tryptophanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+-950 Amino Acid Anal. : Phe (0.98), Cha (0.97), Lys (2.01), Arg (1.06), Pro (0.94) Example 217 <*2. H-Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H)+=827 Example 218 H-Phenylalanyl-Lysyl-Alanyl-Glycyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucy1-Glycyl-OH FAB+ MS: (M+H) + =745 Example 219 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R/S)-2-Amino-3- cyclohexyl-2-methylpropanoyl}-Phenylalanyl-DArginyl-OH {Boc-(2R/S)-2-Amino-3-cyclohexyl-2-methylpropanoic acid} was prepared by hydrogenation of Boc-alpha- methylphenylalanine which was prepared as described in Example No. 232. The reduction was accomplished over a one week period using 1 g of 5% rhodium on carbon for each gram of amino acid in methanol under hydrogen (4 atm) . MS: (M+H)+=286. The peptide was synthesized as described in Example No. 232. FAB+ MS: (M+H)+=875 Amino Acid Anal.: PheMe (1.15), Phe (0.91), Lys (0.94), Arg (1.15), Pro (0.90) Example 220 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-4-phenylbutanoyl}- DArginyl-OH FAB+ MS: (M+H)+=875 .Amino Acid Anal.: Pro (0.97), PheMe (1.00), Cha (1.98), Lys (0.98), Arg (1.08) Example 221 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-( (2R)-2-Amino-4-phenylbutanoyl}- DArginyl-OH FAB+ MS: (M+H)+=875 Amino Acid Anal.: Pro (1.05), PheMe (1.01), Cha (1.92), Lys (0.97), Arg (1.05) Example 222 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2R)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H)+=827 Example 223 H-Phenylalanyl-Lysyl-.Arginyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH FAB+ MS: (M+H)+=827 Amino Acid Anal.: Ala (0.97), Phe (0.96), Cha (2.03), Lys (1.05), Arg (1.01) Example 224 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-D(1-Naphthylalanyl)- Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =905 Example 225 H-DArginyl-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohex lpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH F.AB+ MS: (M+H)+=1009 Amino Acid Anal. : Pro (0.93), Phe (0.96), Cha (2.02), Lys (0.97), Arg (2.12) Example 226 W H-Phenylalanyl-Lysyl-{(2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-.Amino-3-cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl OH FAB+ MS: (M+H) + =940 Example 227 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-DPhenylalanyl-Phenylalanyl-OH FAB + MS: (M+H)+=852 Example 228 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DPhenylalanyl-OH FAB+ MS: (M+H)+=858 Amino Acid Anal. : PheMe (0.98), Phe (1.11), Cha (1.85), Lys (0.99), Pro (1.06) Example 229 H-Sarcosyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl} (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H)+=777 Amino Acid Anal.: Sar (0.94), Lys (0.97), Pro (1.02), Cha (1.95), Arg (0.98) Example 230 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-OMe FAB + MS: (M+H) + =798 .Example 231 (N-Methyl)Phenylalany1-Tyrosyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS : (M+H) +-896 Example 232 H-{ (2R/S)-2-Methylphenylalanyl}-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH This compound was prepared as described in Examples 1 and 2 with the following exception. 1-Hydroxybenzo- triazole (0.5g/g amino acid) was employed as a coupling aid during the incorporation of Boc-2-methylphenylalanine. Commercially available alpha-methyl-D,L-phenylalanine was converted to its t-butyl carbamate with BOC-ON as described in the following reference: Itoh, M.; Hagiwara, D.; Kamiya, T. Bull . Chem. Soc. Jpn . , 1977, 50, 718. MS: (M+H)+=280. FAB+ MS: (M+H)+-861 Amino Acid Anal. : Phe (1.03), Cha (0.93), Lys (0.99), Arg (0.98), Pro (1.05) .Example 233 H-{ (2R/S)-2-Methylphenylalanyl}-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DArginy1-OH FAB+ MS: (M+H)+-861 Amino Acid Anal. : Phe (1.01), Cha (0.96), Lys (0.99), Arg (1.01), Pro (1.17) Example 234 H-Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Arginyl-OH FAB+ MS: (M+H)+-827 Example 235 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Glycyl-Leucyl-Glycyl-OH FAB+ MS: (M+H)+=745 Example 236 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{(2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2RS)-2-Amino-3-cyclohexyl-2- methylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+-881 Amino Acid Anal.: PheMe (1.12), Cha (0.96), Lys (0.98), Arg (1.07), Pro (0.95) Example 237 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2RS)-2-.Amino-5-phenylpentanoyl}- DArginyl-OH FAB+ MS: (M+H)+-889 Example 238 H-Phenylalanyl-Lysyl-DHistidyl-{ (2S)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Arginyl-OH FAB + MS: (M+H) + =1006 Example 239 H-Phenylalanyl-Alanyl-Arginyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=855 Amino Acid Anal.: Ala (0.99), Phe (0.98), Cha (1.48), Arg (2.03) Example 240 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-Alanyl-OH FAB+ MS: (M+H)+=776 Amino Acid Anal.: Ala (1.02), PheMe (0.92), Phe (0.93), Cha (0.92), Lys (0.93), Pro ( 0.99) Example 241 H-Phenylalanyl-Lysyl-Arginyl-Arginyl-Leucyl-Glycyl-Arginyl-OH FAB+ MS : (M+H) +=932 Example 242 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H)+-858 Example 243 (N-Methyl) Phenylalanyl-Lysyl-Prolyl- { (2S) -2-Amino-3- cyclohexylpropanoyl } -DPhenylalanyl-Phenylalanyl-OH FAB + MS : (M+H) + =852 Example 244 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-Glycyl-Phenylalanyl- Arginyl-OH FAB+ MS: (M+H)+=765 Amino Acid Anal. : Gly (1.09), PheMe (0.90), Phe (1.01), Lys (1.02), Arg (0.99), Pro (0.90) Example 245 H-Phenylalanyl-Lysyl-DProlyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =853 Amino Acid Anal. : Phe (0.94), Lys (0.87), Pro (1.08), Cha (2.08), Arg (1.06) Example 246 H-Phenylalanyl-Lysyl-{ (2S)-2-Amino-3-cyclohex lpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DAlanyl-Arginyl-OH FAB + MS: (M+H) + =827 Example 247 (N-Methyl)Phen lalanyl-Tyrosyl-Prolyl-{(2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=902 Example 248 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{2-Amino-2-methylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+=799 Amino Acid Anal. : PheMe (0.99), Cha (0.94), Lys (1.01), Arg (0.99), Pro (1.15) Example 249 H-Phenylalany1-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2R)-2-Amino-3-cyclohexylpropanoyl}- Arginyl-OH FAB + MS: (M+H) + =827 Example 250 H-DPhenylalanyl-Lysyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl-DAlanyl-Arginyl- OH FAB + MS: (M+H) + =940 Amino Acid Anal. : Phe (0.99), Lys (0.95), Cha (1.97), Leu (1.08), Ala (0.97), Arg (1.01) Example 251 (N-Methyl)Phen lalanyl-Lysyl-Prolyl-DNorleucyl-Phenylalanyl- DArginyl-OH W FAB+ MS: (M+H)+-821 Amino Acid Anal. : PheMe (1.07), Nle (1.03), Phe (0.96), Lys (0.93), Arg (1.05), Pro (1.03) Example 252 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Tyrosyl-DArginyl-OH FAB+ MS: (M+H)+=877 Amino Acid Anal. : Pro (1.00), PheMe (0.98), Cha (0.95), Lys (0.99), Arg (1.08) Example 253 (N-Methyl)Phenylalanyl-Lysyl-Alanyl-( (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-Arginyl-NHNH2 FAB+ MS: (M+H)+-886 Example 254 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohex lpropanoyl}- DTyrosyl-OH FAB+ MS: (M+H)+=874 Example 255 (N-Methyl)Phenylalanyl-! (2S)2-Amino-6-ureido-hexanoyl}- Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalany1- DArginyl-OH FAB+ MS: (M+H)+-904 Amino Acid Anal.: PheMe (0.96), Phe (0.98), Cha (0.92), Cit (0.78), Arg (1.02), Pro (1.00) Example 256 H-Phenylalanyl-Arginyl-Methionyl-Arginyl-Leucyl-Glycyl- Arginyl-OH FAB+ MS: (M+H)+=935 /oo Example 257 { (2R/S)-2-Amino-5-phenylpentanoyl}**-Lysyl-Prolyl-{ (2R)-2- Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl** The peptide salt H-{ (2R/S)-2-Amino-5-phenylpentanoyl}- Lysyl(N-epsilon-Trifluoroacetyl)-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylproρanoy1}- DArginyl-OH•2TFA was prepared according to the protocol described in Examples 1 and 2. The peptide (146 mg, 0.12 mmol) was then dissolved in 40% CH3CN (30 mL) ; 1 N HCl (0.5 mL, 0.24 mmol) was added and the mixture was lyophilized to give the hydrochloride salt of the peptide. The resulting white powder was dissolved in dry DMF (15 mL) at -20 °C under N2- Diphenylphosphoryl azide (30 uL, 0.14 mmol) was added followed by triethylamine (83 uL, 0.6 mmol). The mixture was stored in a freezer at -15 °C for 12 d. The dimethyl¬ formamide was then removed in vacuo employing a 40 °C water bath. The resulting oil was purified by HPLC as described in Example 2 to furnish the cyclic peptide in which the epsilon amine of the lysine residue remained protected as its trifluoroacetyl amide. The peptide (43 mg) was dissolved in methanol (2 mL) and water (1.5 mL) and saturated aqueous sodium carbonate solution (0.1 mL) was added. The mixture was stirred overnight at ambient temperature then purified by HPLC to provide the title compound (30 mg, 29%) . FAB+ MS: (M+H)+=863 Amino Acid Anal. : Lys (0.98), Pro (1.10), Cha (1.89), Arg (0.99), hhPhe (0.73) Example 258 H-{ (2R/S)-2-Amino-5-phenylpentanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-DAlanyl-Arginy1-OH FAB + MS: (M+H) + =758 lol Example 259 H-{ (2R/S)-2-.Amino-5-phenylpentanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H)+=758 Example 260 (N-Methyl)Phenylalany1-Alanyl-Lysyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =835 Amino Acid Anal. : PheMe (1.20), Ala (1.02), Lys (0.97), Cha (0.95), Phe (1.00), Arg (1.01) Example 261 H-Phenylalanyl-Lysyl-DAlanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =827 Example 262 N-Acetyl-Phenylalanyl-Lysyl-Ornithyl**-(2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Arginyl** The trifluoroacetic acid salt of H-phenylalanyl- lysyl(N-epsilon-Fmoc)-ornithyl(N-delta-Cbz)-{ (2R)-2~amino-3- cyclohexylpropanoyl}-{ (2S)-2-amino-3-cyclohexylpropanoyl}- Darginyl(N-guanidino-Tos)-O-resin was synthesized according to the method described in Example 1. The resin was washed with 10% diisopropylethylamme in methylene chloride (3x10 mL) and with methylene chloride (3x10 mL) . 10% Diisopropylethylamme in methylene chloride (15 L) , followed by acetic anhydride (10 molar equivalents) were added and the reaction was permitted to proceed at room temperature until a 101 Kaiser test showed negative. The obtained peptide resin was washed with methylene chloride (3x10 mL) and dried. This was treated with HF as described in Example 2 to yield N-alpha acetyl phenylalanyl-lysyl(N-epsiIon-Fmoc)-ornithyl-{ (2R)-2- amino-3-cyclohexylpropanoyl}-{ (2S)-2-amino-3- cyclohexylpropanoyl}-Darginy1-OH. The obtained peptide (300 mg, 0.25 mmol) was dissolved in degassed DMF (150 mL) and cooled to -40 °C. Diphenylphosphoryl azide (DPPA) (83 u, 0.3 mmol) and sodium bicarbonate (105 mg, 125 mmol) were added. The reaction was carried out at -40 °C for 2 d and at 0-5 °C for 2 d. After the solvent was removed, the residue was treated with 20% piperidine in DMF (10 mL) , and the title compound was isolated by the method described in Example 2. F.AB+ MS: (M+H) + =894 Amino.Acid Anal. : Phe (0.98), Lys (0.98), Orn (1.05), Cha (2.15), Arg (1.27) Example 263 H-Arginyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-Phenylalany1- { (2S)-2-Amino-3-cyclohexylpropanoyl}-Lysyl-Leucyl-OH F.AB+ MS: (M+H)+=869 Example 264 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{2-Aminoindan-2- carbonyl}-{ (2S)-2-Amino-3-cyclohex lpropanoyl}-DArginyl-OH The following literature procedure was used to prepare 2-aminoindan-2-carboxylic acid: Pinder, R. M.; Butcher, B. H.; Buxton, D. A.; Howells, D. J. J. Med. Chem. 1971, 14, 892. FAB+ MS: (M+H)+=873 Example 265 H-DPhenylglycyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+-833 Amino Acid Anal. : Phg (0.81), Phe (0.88), Cha (0.98), Lys (0.93), Arg (1.07), Pro (1.11) Example 266 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OMe DArginine methyl ester hydrochloride (131 mg, 0.5 mmol) was coupled to N-Boc-(N-Methyl)Phenylalanyl-Lysyl(N-epsilon- Boc)-Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-! (2S)-2- Amino-3-cyclohexylpropanoyl}-OH (456 mg, 0.5 mmol), which was prepared with the methodology described in Example 322, with l-(3-dimethylaminopropyl)-3-ethyl carbodiimide in 93% yield using the methodology described in: Luly, J. R.; BaMaung, N • r Soderquist, J.; Fung, A. K. L.; Stein, H.; Kleinert, H. D.; Marcotte, P. A.; Egan, D. A.; Bopp, B.; Merits, I.; Bolis, G.; Greer, J.; Perun, T. J.; Plattner, J. J. J. Med. Chem. 1988, 31 , 2264-2276. Deprotection in 50% trifluoroacetic acid/methylene chloride followed by HPLC purification as described in Example 2 furnished the title compound in 60% yield. FAB+ MS: (M+H)+-881 Amino Acid Anal. : PheMe (0.80), Lys (0.98), Pro (1.00), Cha (1.84), Arg (1.00) Example 267 H-Phenylalanyl-DLysyl-! (2S)-2-Amino-3-cyclohexylpropanoyl}- ! (2S)-2-Amino-3-cyclohex lpropanoyl}-Leucyl-DAlanyl-Arginyl- OH FAB + MS: (M+H) + =940 Amino Acid Anal. : Phe (0.97), Lys (0.93), Cha (2.03), Leu (1.09), Ala (0.98), Arg (1.03) Example 268 (N-Methyl)Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ .MS: (M+H)+=835 Amino Acid Anal. : PheMe (1.03), Lys (1.03), Ala (1.00), Cha (0.95), Phe (0.99), Arg (0.99) Example 269 (N-Methyl)Phenylalany1-Lysyl-Prolyl-DAlanyl-Phenylalany1- DArginyl-OH FAB+ MS: (M+H)+=779 Amino Acid Anal.: Pro (0.96), Ala (0.93), PheMe (0.98), Phe (1.07), Lys (0.97), Arg (1.07) Example 270 (N-Methyl)DPhenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alany1-Leucyl-Arginyl-OH FAB+ MS: (M+H) + =872 Example 271 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohex lpropanoyl}-Phenylalanyl-{ (2R/S)-2-.Amino-3,3- cyclopropy1-3-phenylpropanoyl}-OH 1-Phenyl-l-cyclopropane methanol was oxidized with activated dimethylsulfoxide (Mancuso, A. J.; Huang, S-L.; Swern, D. J. Org. Chem. 1978, 43, 2480-2482) . This ketone was converted to (2R/S)-2-amino-3,3-cyclopropyl-3- phenylpropanoic acid according to the procedure given in: Gaudry, R. Can. J. of Res. 1948, 26, Sec. B, 387: X H NMR (CDCI 3 , 300 MHz) δ 1.08-1.12 (m, 3 H) , 1.42 (m, 1 H), 3.51 (s, 1 H), 7.32-7.44 (m, 5 H) ; mass spectrum, m/e 192(M+H) . (2R/S)-2-Amino-3,3-cyclopropyl-3-phenylpropanoic acid was coupled with N-Boc-(N-methyl)phenylalany1-lysyl(N-epsilon- 10$ Boc)-prolyl-! (2R)-2-amino-3-cyclohexylpropanoyl}- phenylalanyl-OH as described in Example 322. The diastereomeric pair were purified and separated in a combined yield of 52% by HPLC as described in Example 2. FAB+ MS : (M+H)+=878 Amino Acid Anal. : PheMe (0.89), Lys (0.99), Pro (1.01), Cha (1.03), Phe (1.06) Example 272 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-(2R/S)-2-Amino-3,3- cyclopropyl-3-phenylpropanoyl}-OH This compounds was prepared as described in Example 271. F.AB+ MS: (M+H)+=878 Amino Acid Anal. : PheMe (1.00), Lys (0.98), Pro (1.01), Cha (1.11), Phe (1.14) Example 273 (N-Methyl)Phenylalany1-Lysyl-Phenylalanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=911 Amino Acid Anal.: PheMe (1.05), Phe (2.00), Cha (0.94), Lys (0.95), Arg (1.05) Example 274 H-Phenylalanyl-Arginyl-Methionyl-Glutaminyl-Leucyl-Glycyl- Arginyl-OH FAB+ MS: (M+H) + =907 Example 275 H-Phenylalanyl-Lysyl-Azaglycyl-1 (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH This peptide is prepared using methodology similar to that described in: Dutta, A. S.; Giles, M. B.; Williams, J. C. J. Chem. Soc , Perkin Trans. 1 1986, 1655-64; Dutta, A. S.; Giles, M. B.; Gormley, J. J.; Williams, J. C; Kusner, E. J. J " . Chem. Soc , Perkin Trans. 1 1987, 111-120. Example 276 H-Lysyl-! (2R/S)-2-Amino-5-phenylpentanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-DAlanyl-Arginy1-OH FAB+ MS: (M+H) + =886 Amino Acid Anal. : Lys (0.96), hhPhe (0.83), Cha (0.98), Ala (2.00), Leu (1.05), Arg (1.01) Example 277 H-Lysyl-! (2R/S)-2-Amino-5-phenylpentanoyl}-! (2S)-2-Amino-3- cyclohex lpropanoyl}-Alanyl-Leucyl-DAlanyl-Arginy1-OH FAB + MS: (M+H)+=886 Amino Acid Anal. : Lys (1.01), hhPhe (0.85), Cha (0.97), Ala (1.98), Leu (1.04), Arg (1.00) Example 278 (N-Methyl)Phenylalany1-Lysyl-Tyrosyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H)+=933 Amino Acid Anal.: PheMe (1.24), Lys (0.99), Tyr (0.98), Cha (1.97), Arg (1.03) Example 279 (N-Methyl)Phenylalanyl-Lysyl-{2-Amino-2-methylpropanoyl}- { (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=849 Example 280 N-Acetyl-Phenylalanyl-Lysyl-DOrnithyl**- (2R) -2-Amino-3- cyclohexylpropanoyl}- { (2S) -2-Amino-3-cyclohexylpropano 1 } - DaArginyl** The title compound was prepared in analogy to Example 262. FAB + MS: (M+H)+=894 Amino Acid Anal.: Phe (0.94), Lys (0.95), Orn (1.00), Cha (1.91), Arg (1.11) Example 281 H-l (2S)-2-Amino-3-cyclohexylpropanoyl}-! (2S)-2-Amino-3- cyclohexylpropanoyl}-Lysyl-Leucyl-DAlanyl-Arginyl-OH FAB + .MS: (M+H)+=793 Example 282 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-! (2R/S)-o-Fluorophenylalanyl}- DPhenylalanyl-OH FAB + MS: (M+H) + =870 Example 283 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2R/S)-o-Fluorophenylalanyl}- DPhenylalanyl-OH FAB+ MS: (M+H)+=870 Example 284 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-DArginyl-OH FAB+ MS: (M+H)+=785 Amino Acid Anal. : Ala (0.63), PheMe (0.97), Cha (0.89), Lys (0.98), Arg (0.97), Pro (1.04) Example 285 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-NHNH2 m Hydrazine (40 uL) was added to a methanolic (10 mL) solution of Boc-(N-Methyl)Phenylalanyl-Lysyl(N-epsilon-Boc)- Prolyl-{ (2R)-2-Amino-3-eyelohex lpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OCH3 (100 mg, 0.1 mmol). The reaction was complete after stirring at room temperature overnight. The volatiles were removed under reduced pressure and the Boc groups were removed with 50% trifluoroacetic acid in methylene chloride. Following HPLC purification as described in Example 2, the title compound was obtained in 67% yield. FAB + MS: (M+H) + =881 Amino Acid Anal. : PheMe (0.82), Lys (0.98), Pro (1.04), Cha (1.89), Arg (0.98) Example 286 N-Acetyl-Phenylalanyl-Lysyl-Alanyl- { (2S) -2-Amino-3- cyclohexy lpropanoyl }-Alanyl-Leucyl-DTyrosyl-NHNH2 FAB + MS : (M+H) +=921 Example 287 (N-Methyl)Phenylalany1-Alanyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=804 Amino Acid Anal.: PheMe (1.01), Ala (1.04), Pro (1.04), Cha (0.88), Phe (0.99), Arg (0.99) Example 288 H-Phenylalanyl-DLysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =827 Example 289 /** H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DLysy1-DArginy1-OH FAB + MS: (M+H)+=955 Example 290 ! (2R/S)-2-Amino-5-phenylpentanoyl}**-Lysyl-Prolyl-( (2R)-2- Amino-3-cyclohexylpropanoyl}-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-Glycyl** The compound was prepared in a manner identical to that as described for Example No. 257. FAB+ MS: (M+H)+=921 Amino Acid Anal.: Lys (0.94), Pro (1.02), Cha (1.84), Arg (1.01), Gly (1.03), hhPhe (0.81) Example 291 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DLeucyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-Arginyl-OH FAB+ MS: (M+H)+=827 Amino Acid Anal. : PheMe (1.01), Leu (0.99), Cha (0.88), Lys (1.00), Arg (1.09), Pro (1.02) Example 292 H-Phenylalanyl-Lysyl-Arginyl-Methionyl-Glutaminyl-Leucyl- Glycyl-OH FAB + MS: (M+H)+=879 Example 293 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Arginyl-NHNH 2 FAB+ MS: (M+H) + =939 Example 294 HO H-Phenylalanyl-Lysyl-Lysyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH FAB + MS: (M+H) + =799 Amino Acid Anal. : Phe (1.02), Lys (1.97), Cha (1.96), Ala (1.01) Example 295 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylglycyl-DArginyl-OH FAB+ MS: (M+H)+=847 Amino Acid Anal.: Phg (1.01), PheMe (0.87), Cha (1.04), Lys (0.78), Arg (1.12), Pro (1.16) Example 296 Phenylalanyl**-Lysyl-Prolyl-{(2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl** The title compound was prepared in analogy to Example 257. FAB+ MS: (M+H)+=835 Amino Acid Anal.: Phe (0.98), Lys (1.01), Pro (1.11), Cha (1.95), Arg (1.02) Example 297 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Glycyl-Arginyl-OH FAB + MS: (M+H) + =731 Example 298 (N-Methyl)Phenylalanyl-Lysyl-{2-Aminoindan-2-carbony}-{ (2R)- 2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH The following literature procedure was used to prepare 2-aminoindan-2-carboxylic acid: Pinder, R. M.; Butcher, B. II H.; Buxton, D. A.; Howells, D. J. J". Med. Chem. 1971, 14, 892. FAB+ MS: (M+H)+=929 Example 299 (N-Methyl)Phenylalany1-Norleucyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=846 Amino Acid Anal. : PheMe (1.00), Phe (0.93), Cha (0.92), Arg (1.00), Pro (1.07) .Example 300 H-Glycyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}- { (2R/S)-2-Amino-5-phenylpentanoyl}-DArginyl-OH FAB + MS: (M+H) + =785 Example 301 H-Glycyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}- (2R/S)-2-Amino-5-phenylpentanoyl}-DArginyl-OH FAB + MS: (M+H) + =785 Example 302 H-Phenylalanyl-Gutamyl(NHNH2)-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DArginyl-NHNH2 FAB + MS: (M+H) + =887 Example 303 (N-Methyl)Phenylalanyl-{ (2S)-2-Amino-6-[guanidino(N{2- imidazolinyl}-N,N'-ethylene]-hexanoyl}-Prolyl-! (2R)-2-Amino- 3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH-3 HOAc was prepared as described in Examples 1 and 2. This peptide (100 mg, 0.1 mmol) , used without HPLC purification, was dissolved in NaOH solution (I N, 0.5 ml) . The reaction mixture was diluted with acetone/water 2:1 (1.5 mL) and methylthioimidazoline hydroiodide (85 mg, 0.35 mmol) was added. The reaction mixture was stirred at 50 °C overnight. The acetone was then removed in vacuo, the resulting aqueous solution acidified to pH 3 with trifluoroacetic acid, and acetonitrile added to dissolve any material that may oil out of the solution. The mixture was purified by HPLC using conditions described in Example 2 to give the title compound (3.1 mg, 3% yield) . F.AB + MS: (M+H) + =998 .Amino Acid Anal.: PheMe (0.99), Phe (0.85), Pro (1.02), Cha (0.97), Arg (1.14) Example 304 (N-Methyl)Phenylalanyl-{ (2S)-2-Amino-6-(N<3'- phenylguanidinyl)-hexanoyl}-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH (N-Methyl)Phenylalanyl-Lysyl-Prolyl-1 (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginy1-OH•3 HOAc was prepared as described in Examples 1 and 2. This peptide (100 mg, 0.1-mmol), used without HPLC purification, was dissolved in sodium hydroxide solution (I N, 0.5 mL) . The reaction mixture was diluted with acetone/water 2:1 (1.5 mL) and (2- methyl-3-phenyl-2-thiopseudo-thiourea hydroiodide (103 mg, 0.35 mmol) was added. The reaction mixture was stirred at 50 °C overnight. The acetone was then removed in vacuo, the resulting aqueous solution acidified to pH 3 with trifluoroacetic acid, and acetonitrile added to dissolve any l it material that may oil out of the solution. The mixture was then purified by HPLC conditions as described in Example 2 to furnish the title compound (8 mg, 0.1 % yield). FAB+ MS: (M+H)+=980 Amino Acid Anal.: PheMe (1.08), Phe (0.98), Pro (1.04), Cha (1.03), Arg (0.98) Example 305 (N-Methyl)Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)- Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+=963 Amino Acid Anal.: Pro (0.94), PheMe (1.18), Cha (1.75), Lys (1.01), Arg (1.11) Example 306 H-Lysyl-DPhenylalanyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=827 Example 307 (N-Methyl)Phenylalanyl-Lysyl-Glycyl-( (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DPhenylalanyl-OH FAB+ MS: (M+H)+=812 Amino Acid Anal. : Gly (0.91), PheMe (1.10), Phe (2.09), Cha (0.99), Lys (1.05) Example 308 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-!2-aminocyclohexanecarbonyl}-DArginyl-OH FAB + MS: (M+H)+=839 Example 309 / /</ H-Phenylalanyl-. A rginyl-Methionyl-Glutaminyl-Leucyl-Glycyl-OH FAB + MS: (M+H) + -751 Example 310 H-Pheny lalany l-Lysyl-Penicillaminyl*-{ (2S) -2-Amino-3- cyclohexylpropanoyl }- { (2S) -2-.Amino-3-cyclohexylpropanoyl }- DCysteinyl*-Arginyl-OH FAB + MS : (M+H) + =988 Example 311 (N-Methyl)Phenylalanyl-Lysyl-Lysyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH FAB + MS: (M+H) + =813 Amino Acid Anal. : PheMe (0.99), Lys (1.98), Cha (2.00), Ala (1.02) Example 312 (N-Methyl)Phenylalany1-Lysyl-Prolyl-Phenylglycyl-Alanyl- DArginyl-OH FAB+ MS: (M+H)+=765 Amino Acid Anal.: Ala (0.60), Phg (1.00), PheMe (0.96), Lys (1.03), Arg (1.00), Pro (0.91) Example 313 H-Phenylalanyl-Lysyl-Proly1-DAlanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB + MS: (M+H) + =771 Amino Acid Anal.: Phe (0.99), Lys (1.02), Pro (0.93), Ala (0.97), Cha (1.01), Arg (1.03) Example 314 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-Glycyl-OH IIS FAB+ MS: (M+H)+=841 Example 315 H-!2-.Aminoindan-2-carbonyl}-Lysy1-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH The following literature procedure was used to prepare 2-aminoindan-2-carboxylic acid: Pinder, R. M.; Butcher, B. H.; Buxton, D. A.; Howells, D. J. J. Med. Chem. 1971, 14, 892. FAB+ MS: (M+H)+=865 Example 316 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-1 (2R)-2-Amino-3- cyclohexylpropanoyl}-Norleucyl-DArginyl-OH FAB+ MS : (M+H)+=827 Example 317 H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DLysyl-OH F.AB+ MS: (M+H)+=825 Amino Acid Anal. : Pro (1.20), Phe (1.06), Cha (1.81), Lys (1.94) Example 318 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-Alanyl-Leucyl-DArginyl-NHNH2 FAB + MS: (M+H)+=872 Example 319 UC (N-Methyl)Phenylalanyl-(Lysyl(N-epsilon-[N-(1,3- Diaminopropyl)carbonyl]) }-Prolyl-( (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH The peptide Boc-(N-Methyl)Phenylalanyl-Lysyl(Fmoc)- Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl- DArginyl(N-guanidino-Tos)-OResin was synthesized according to the protocol described in Example 1, and the Fmoc protecting group was removed by treatment of the peptide-resin with piperidine according to the method shown in: Stewart, J. M.; Young, J. D."Solid Phase Peptide Synthesis", 2nd edition; Pierce Chemical Co.: Rockford, Illinois, 1984; p 83. The resin, Boc-(N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino- 3-cyclohexyIpropanoy1}-Phenylalanyl-DArginyl(N-guanidino- Tos)-OResin (2.42 g, ca 0.96 meq) , was agitated overnight with a nitrogen stream in a solution of dicarbonyl imidazole (1.6 g in 30 mL dimethylfo.rmamide) to fo.rm the carbonyl- imidazole derivative of lysine. The resin was then washed with dimethylformamide followed by methylene chloride and finally dried in a vacuum oven at room temperature overnight. The modified peptide-resin (0.74 g, ca 0.25 meq) was swelled with dimethyl-formamide and the solvent removed by filtration. The resin was then agitated overnight with a nitrogen stream in a solution of propanediamine (0.21 mL, 2.5 mmol) in dimethylformamide (20 ml) . The resin was removed by filtration, washed with dimethylformamide and methylene chloride, and dried by aspiration. The peptide was then cleaved from the resin by treatment with anhydrous HF and purified by HPLC as described in Example 2 to supply the title compound (20 mg, 7% yield) . FAB + MS: (M+H) + =961 Amino Acid Anal. : PheMe (0.90), Phe (0.90), Lys (0.55), Pro (1.10), Cha (0.87), Arg (1.06) in Example 320 (N-Methyl ) Phenylalanyl-Lysyl-Prolyl -DPhenylalanyl-Alanyl- DArginyl-OH FAB+ MS : (M+H) +=779 Amino Acid Anal . : Pro (1.02 ) , Ala (0 .72) , PheMe (1 .03) , Phe (1 .09) , Lys (1.04) , Arg (1 .09) Example 321 H-DLysyl-Phenylalanyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=827 Example 322 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{D-4-Nitro-ρhenylalanyl}-OH Commercially available D-phenylalanine methyl ester hydrochloride (12 g) was hydrogenated with 5% rhodium on carbon (1.2 g) in 250 mL of methyl alcohol to yield (2R)-2- amino-3-cyclohexyl propanoic acid methyl ester hydrochloride in 97% yield. This (5.0 g, 18.4 mmol) was coupled with Boc- L-proline (3.97 g, 18.4 mmole) by standard methods [(1- hydroxybenzotriazole monohydride (HOBt) (2.74 g, 20 mmol), N- methylmorpholine (NMM) (2.23 mL, 20 mmol) and 1-(3-dimethyl- aminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (3.89 g, 20 mmol) as exemplified by the methods described in "Peptide Synthesis", Second Edition, Bodanszky, M.; Klausner, Y. S. and Ondetti, M. A., (1976) in 71% yield. The Boc-group was cleaved with 4 N hydrochloric acid in dioxane, and the obtained prolyl-(2R)-2-amino-3-cyclohexylpropanoic acid methyl ester hydrochloride was reacted with N-alpha-Cbz-N- epsilon-Boc-lysine (quantitative yield) according to the method mentioned above. The N-alpha-Cbz group was removed by H8 hydrogenolysis (20%-palladium on charcoal 10%w/w) in acetic acid-isopropanol, and the obtained product was coupled with Boc-(N-methyl)phenylalanine by the above method to obtain N- Boc-(N-methyl)phenylalanyl-lysyl(N-epsilon-Boc)-prolyl-{ (2R)- 2-amino-3-cyclohexylpropanoic acid methyl ester} in quantitative yield. Finally, the methyl ester (7.33 g, 9.5 mmole) was cleaved by treatment with 1.5 molar equivalents of lithium hydroxide (598 mg, 14.25 mmol) in 115 mL of methanol- water (2:1) mixture to obtain N-Boc-(N-methyl)phenylalanyl- lysyl(N-epsilon-Boc)-prolyl-{ (2R)-2-amino-3-cyclohexyl- propanoic acid} in 83% yield. FAB + MS: (M+H) + =758 N-Boc-(N-methyl)phenylalanyl-lysyl(N-epsilon-Boc)- prolyl-{ (2R)-2-amino-3-cyclohexylpropanoic acid (1.5 g, 2 mmol) was reacted with phenylalanine methyl ester hydrochloride in tetrahydrofuran by the mixed anhydride method (isobutylchloroformate and N-methylmorpholine) as exemplified by the methods described in "Peptide Synthesis", Second Edition, Bodanszky, M.; Klausner, Y. S. and Ondetti, M. A., (1976) to obtain N-Boc-(N-methyl)phenylalanyl-lysyl(N- epsilon-Boc)-prolyl-{ (2R)-2-amino-3-cyclohexylpropanoyl- phenylalanine methyl ester in quantitative yield. The methyl ester (1.7 g, 1.8 mmole) was saponified with 1.5 equivalents of lithium hydroxide (160 mg, 2.7 mmole) in 20 mL of methanol and water (2:1) according to the procedure described above to yield N-Boc-(N-methyl)phenylalanyl-lysyl(N-epsilon-Boc)- prolyl-{ (2R)-2-amino-3-cyclohexylpropanoyl}-phenylalanyl-OH in 99% yield. N-Boc-(N-Methyl)Phenylalanyl-Lysyl(N-epsilon-Boc)- Prolyl-{ (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl- OH(0.18 mmol) was dissolved in 3 mL of methylene chloride at -20 °C, and triethylamine (25 uL, 0.18 mmol) and U -) isobutylchloroformate (25 uL, 0.18.mmol) were added. After D-4-nitrophenylalanine (0.3 mmol) in 1 mL of dimethyl¬ formamide containing triethylamine (41.8 uL, 0.3 mmol) was added, the reaction was carried out at 20 °C for 1 h and at room temperature for one overnight. Solvent was removed and the residue was dissolved in ethyl acetate which was washed with brine, 10% potassium hydrogen sulfate, brine and dried over magnesium sulfate. Solvent was removed and the residue was treated with 4 N hydrochloric acid in dioxane to yield a crude title compound. HPLC purification gave the pure title compound. F.AB+ MS: (M+H)+=897 Example 323 H-Phenylalanyl-Lysyl-Prolyl-D.Arginyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+-856 Amino Acid Anal. : Phe (0.95), Cha (0.96), Lys (0.92), Arg (2.07), Pro (1.11) Example 324 H-Phenylalanyl-Arginyl-Methionyl-Glutaminyl-Leucyl-Glycyl- Alanyl-OH FAB+ MS: (M+H)+=822 Example 325 H-Phenylalanyl-Lysyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Alanyl-Leucyl-DAlanyl-Arginyl-OH FAB+ MS: (M+H)+=858 Amino Acid Anal.: Phe (1.00), Lys (1.01), Cha (0.97), Ala (1.95), Leu (1.04), Arg (1.00) Example 326 H-Phenylalanyl-Alanyl-Lysyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=827 Amino Acid Anal. : Phe (1.00), Ala (0.99), Lys (0.99), Cha (1.94), Arg (1.03) .Example 327 (N-Methyl)Phenylalany1-Lysyl-Aspartyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H)+=879 Example 328 H-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Alany1-DArginyl-OH FAB + MS: (M+H)+=771 Amino Acid Anal. : Phe (0.98), Lys (0.99), Pro (1.13), Cha (1.00), Ala (0.70), Arg (1.03) Example 329 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alany1-Glycyl-OH FAB+ MS: (M+H)+=646 Example 330 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DLysyl-OH FAB+ MS: (M+H)+=833 Amino Acid Anal. : PheMe (0.67), Lys (1.94), Pro (1.04), Cha (0.98), Phe (1.03) Example 331 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalany1-DTyrosyl-OH FAB + MS: (M+H)+=868 \ Z l Example 332 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl-{ (2R 2-Amino-3-cyclohexylpropanoyl}-{ (2S)-2-.Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+=949 Amino Acid Anal.: Pro (0.84), Phe (1.15), Cha (1.95), Lys (0.99), Arg (1.08) Example 333 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DValyl-DArginyl-OH FAB+ MS: (M+H) + =926 Example 334 (N-Methyl)Phenylalanyl-{ (2S)-2-Amino-6-acetamidinyl- hexanoyl}-Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}- Phenylalanyl-DArginyl-OH The peptide Boc-(N-Methyl)Phenylalanyl-Lysyl(Fmoc)- Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl- DArginyl(N-guanidino-Tos)-OResin was synthesized according the protocol described in Example 1, and the Fmoc protectin group was removed by treatment of the peptide-resin with piperidine according to the method shown in: Stewart, J. M. Young, J. D."Solid Phase Peptide Synthesis", 2nd Edition; Pierce Chemical Co.: Rockford, Illinois, 1984; p 83. The resin, Boc-(N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amin 3-cyclohexylpropanoy1}-Phenylalanyl-DArginyl(N-guanidino- Tos)-OResin (0.6 g, ca 0.25 meq) was suspended in a solutio of diisopropyl-ethylamine (0.44 mL, 2.5 mmol) in dimethylformamide (8 mL) . Methyl acetimidate hydrochloride (0.14 g, 1.25 mmol) was added and the suspension stirred gently for 24 h at 50 °C. The resin was removed by filtration, washed with dimethylformamide (2 portions) and methylene chloride (2 portions), and dried by aspiration. The peptide was then cleaved from the resin by treatment with anhydrous HF and purified by HPLC as described in Example 2 to provide the title compound (131 mg, 46% yield) . FAB + MS: (M+H)+=902 Amino Acid Anal.: PheMe (0.81), Phe (0.97), Lys (0.37), Pro (1.13), Cha (0.88), Arg (1.03) Example 335 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-4- phenylbutanoyl}-Alany1-DArginyl-OH FAB+ MS: (M+H)+=793 Amino Acid Anal. : Pro (1.05), Ala (0.73), PheMe (1.04), Cha (1.08), Lys (1.00), Arg (1.09) Example 336 H-Phenylalanyl-Lysyl-Alany1-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-.Amino-3-cyclohexylpropanoyl}- ! (2R)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H) + =980 Example 337 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalanyl-! (R/S)-2- Fluorophenylalany1}-OH This compound was prepared in analogy to Example No. 322. FAB+ MS: (M+H)+=870 Example 338 IZ3 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalanyl-{ (R/S)-2- Fluorophenylalanyl}-OH This compound was prepared in analogy to Example No, 322. FAB+ MS: (M+H)+=870 Example 339 (N-Methyl)Phenylalanyl-Lysyl-(2-Naphthylalanyl)-{ (2R)-2- Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=961 .Ammo Acid Anal.: PheMe (0.93), Phe (1.01), Cha (0.91), Lys (0.97), Arg (1.02) Example 340 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH FAB+ MS: (M+H) + =782 Amino Acid Anal. : Phe (0.91), Lys (0.99), Pro (1.13), Cha (1.98), Ala (1.03) Example 341 H-Phenylalanyl-Lysyl-Alanyl-Alanyl-Leucyl-DAlanyl-Arginyl-OH F.AB+ MS: (M+H)+=776 .Amino Acid Anal.: Phe (0.99), Lys (0.99), " Ala (2.84), Leu (1.03), Arg (0.99) Example 342 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- { (R/S)t-Butylalanyl}-OH FAB+ MS: (M+H) + =838 Example 343 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- { (R/S)t-Butylalanyl}-OH FAB+ MS: (M+H)+=838 Example 344 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-D{3-(2'-Thienyl)alanyl}- Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =861 Example 345 (N-Allyl) Phenylalanyl-Lysyl-Alanyl- { (2R) -2-Amino-3- cyclohexylpropanoyl } - { (2S) -2-Amino-3-cyclohexy lpropanoyl } - DArginyl-OH FAB+ MS : (M+H) +=867 Example 346 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DLysyl-OH FAB+ MS: (M+H)+=839 Amino Acid Anal. : PheMe (0.67), Lys (1.98), Pro (1.02), Cha (1.94) Example 347 H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-Alany1-Leucy1-Glycyl-OH FAB + MS: (M+H)+=759 Example 348 12.5 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-!p-Iodophenylalanyl}-DPhenylalanyl-OH FAB+ MS: (M+H)+-978 Example 349 (N-Methyl)Phenylalanyl-Seryl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-D.Arginyl-OH FAB+ MS: (M+H)+«820 Amino Acid Anal.: Ser (0.58), PheMe (1.06), Phe (0.98), Cha (0.94), Arg (1.03), Pro (1.02) Example 350 (N-Methyl)Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)- Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}-Leucyl-DArginyl- OH FAB+ MS: (M+H)+=923 Amino Acid Anal.: Pro (0.99), PheMe (1.00), Leu (1.04), Cha (0.94), Lys (0.98), Arg (1.03) Example 351 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Arginyl-OH FAB+ MS: (M+H)+-827 .Example 352 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S) -2-Amino-3-cyclohexylpropanoyl}- ! (R) -Phenylglycinyl}-OH (R)-Phenylglycine was converted to its benzyl carbamate with Cbz-Cl under Schotten-Baumann conditions (Greenstein, J. P.; Winitz, M. "Chemistry of the Amino Acids", 3rd ed.; Robert E. Krieger Publishing Co., Inc.: Malabar, Florida, 1986; Vol. 2, p 891.) in 68% yield: mass l 2-C spectrum, m/e 286(M+H) . Conversion to the t-butyl ester was accomplished with isobutylene in dioxane in the presence of a catalytic amount of sulfuric acid in 78% yield. The Cbz group was removed by hydrogenation to give (R)-phenylglycine t-butyl ester in 78% yield: mass spectrum, m/e 208(M+H) . This ester was reacted with N-Boc-(N-Methyl)Phenylalanyl- Lysyl(N-epsilon-Boc)-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoic acid} (prepared by the methodology described in Example 322) under the conditions described in Example 322. Following deprotection with 50% trifluoroacetic acid in methylene chloride, the title compound was obtained in 41% yield following HPLC purification as described in Example 2. FAB + MS: (M+H) + =844 Amino Acid Anal. : PheMe (0.77), Lys (0.97), Pro (1.03), Cha (1.94), Phg (0.96) Example 353 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DValyl-Phenylalanyl- DArginyl-OH FAB+ MS: (M+H)+=807 Amino Acid Anal. : Pro (0.96), Val (1.05), PheMe (0.99), Phe (1.03), Lys (0.96), Arg (1.00) Example 354 H-Lysyl-Phenylalanyl-Alanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =827 Example 355 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DPhenylalanyl-! (2S)-2- Amino-3-cyclohexylpropanoyl}-DArginyl-OH 1 2--J FAB+ MS: (M+H)+=861 Amino Acid Anal. : PheMe (0.84), Phe (1.00), Cha (0.90), Lys (0.83), Arg (1.00), Pro (1.07) Example 356 (N-Benzyl)Prolyl-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH The trifluoroacetic acid salt of Prolyl-Lysyl(N- epsilon-Cbz)-Prolyl-! (2R)-2-Amino-3-cyclohexylpropanoyl}- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl(N-guanidino- Tos)-OResin was prepared according to the procedure described in Example 1. The peptide-resin obtained (0.55 g) was washed with 10%-diisopropylethylamine (DIEA) in methylene chloride (3x15 mL) and methylene chloride (3x15 mL) and was suspended in DMF (15 mL, containing 1%-acetic acid) . Benzaldehyde (10 equivalent mole) and sodium cyanoborohydride (10 equivalent mole) were added and reacted for 1 hr. After the resin obtained was washed with DMF (3x15 mL) and methylene chloride (3x15 mL) , it was treated with HF and anisole and purified by HPLC, according to the procedure described in Example 2. FAB + MS: (M+H) + =893 Amino Acid Anal. : Lys(0.95), Pro (1.24), Cha (2.04), Arg (1.05) Example 357 H-Lysyl-Aspartyl-! (2S)-2-Amino-3-cyclohexylpropanoyl}-! (2S)- 2-Amino-3-cyclohexylpropanoyl}-Leucyl-DArginyl-Arginyl-OH FAB + MS: (M+H)+=993 Amino Acid Anal. : Lys (1.00), Asp (0.90), Cha (1.90), Leu (1.03), Arg (1.97) Example 358 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (R/S)t-Butylalanyl- { (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl-OH . ≥z FAB + MS: (M+H) + =841 Example 359 H-{3-(2'-Thienyl)alanyl}-Lysyl-Prolyl-D{3-(2'- Thienyl)alanyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =853 Example 360 H-Phenylalanyl-Lysyl-Valyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB+ MS: (M+H)+=855 Amino Acid Anal.: Val (0.99), Phe (0.89), Cha (2.07), Lys (0.93), Arg (1.12) Example 361 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2R/S)-p-Fluorophenylalanyl}- DPhenylalanyl-OH F.AB+ MS: (M+H)+=870 Example 362 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Aminσ-3- cyclohexylpropanoyl}-! (2R/S)-p-Fluorophenylalanyl}- DPhenylalanyl-OH F.AB+ MS: (M+H)+=870 Example 363 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2R)-2-Amino-3-cyclohexylpropanoyl}- ! (R/S)-2-Benzyl-arginyl}-OH The preparation of this compound is described in Example 378. F.AB + MS: (M+H) + =957 PheMe(0.73), Lys (1.07), Pro (0.93), Cha (1.83) Example 364 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2R)-2-Amino-3-cyclohexylpropanoyl}- ! (R/S)-2-Benzyl-arginyl}-OH The preparation of this compound is described in Example 378. FAB + MS: (M+H) + =957 PheMe(0.74), Lys (1.00), Pro (1.00), Cha (1.87) Example 365 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl-1 (2R)- 2-Amino-3-cyclohexylpropanoyl}-Glutaminyl-DArginyl-OH FAB+ MS: (M+H)+=924 Amino Acid Anal. : Glx (1.05), Pro (0.96), Phe (0.96), Cha (0.99), Lys (0.97), Arg (1.05) Example 366 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DLysyl-OH FAB + MS:- (M+H) + =912 Example 367 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-! (R)-Phenylglycinyl}-OH The title compound was prepared in analogy to Example 352 in 38% yield. ι 3C FAB+ MS: (M+H) + =838 Amino Acid Anal. : PheMe (0.73), Lys (0.98), Pro (1.01), Cha (0.93), Phe (1.01), Phg (1.00) Example 368 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Arginyl-OH FAB+ MS: (M+H)+=867 Amino Acid Anal. : Pro (1.07), PheMe (1.02), Cha (1.94), Lys (0.99), Arg (1.07) Example 369 (N-Methyl)Phenylalanyl-Lysyl-! (2S)-2-Amino-4-pentenoyl}- { (2R)-2-Amino-3-cyclohex lpropanoyl}-Phenylalanyl-DArginyl- OH Commercially available L-2-amino-4-pentenoic acid is converted to its N-tert-butoxycarbonyl derivative using the methodology described in: Keller, 0.; Keller, W. E.; van Look, G.; Wersin, G Organic Syntheses 1984, 63, 160-170. The N-protected amino acid is incorporated into the peptide under standard solid phase conditions as described in Examples 1 and 2. Example 370 H-Phenylalanyl-Lysyl-Alanyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H)+=827 Example 371 (N-Methyl) (2R/S) (m-Fluoro)Phenylalanyl-Lysyl-Prolyl-! (2R)-2- Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH 13/ F.AB+ MS: (M+H) + =879 Example 372 (N-Methyl) (2R/S) (m-Fluoro)Phenylalanyl-Lysyl-Prolyl-! (2R)-2- Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =879 Example 373 (N-Methyl)DProlyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =817 Amino Acid Anal. : Lys (0.95), Pro (1.34), Cha (2.05), Arg (1.05) Example 374 H-Lysyl-{ (2S)-2-Amino-4-phenylbutanoyl}-! (2S)-2-.Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DAlanyl-Arginyl-OH FAB + MS: (M+H) + =954 Amino Acid Anal. : Lys (1.00), hPhe/Cha (2.90), Leu (1.04), Ala (0.98), Arg (0.98) Example 375 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (RS)t-Butylalany1-DArginy1-OH F.AB+ MST (M+H) + =841 Example 376 H-{3-(2•-Thienyl)alanyl}-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-(3-(2•-Thienyl)alanyl}-DArginyl-OH FAB + MS: (M+H)+=859 Example 377 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl- DPhenylalanyl-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-DArginyl- OH FAB+ MS: (M+H)+=943 Amino Acid Anal. : Pro (1.04), Phe (2.13), Cha (0.89), Lys (0.96), Arg (0.97) Example 378 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohex lpropanoyl}- { (R/S)-2-Benzyl-arginyl}-OH (N-alpha-Boc, N-deIta-Cbz)Ornithine was converted to its benzyl ester in 98% yield (mass spectrum, m/e 457[M+H]) according to: Wang, S-S.; Gisin, B. F.; Winter, D. P.; Makojske, R.; Kulesha, I. D.; Tzougraki, C; Meienhofer, J. J. Org. Chem. 1977, 42, 1286-1290. The Boc group was removed by treatment with 4 N hydrochloric acid in dioxane over 1 h. Benzylation on the alpha carbon was accomplished using a solid-liquid catalytic phase-transfer alkylation procedure: O'Donnell, M. J.; LeClef, B.; Rusterholz, D. B. Tetrahedron Lett . 1982, 23, 4259-4262. This supplied (R/S)- (N-delta-Cbz)-2-benzyl-ornithine benzyl ester in 75% yield: - ~ B. NMR (CDC13, 300 MHz) 61,3 (m, 1 H) , 1.6 (m, 2 H) , 1.93 (m, 1 H), 2.25 (d, 1 H) , 3.15 (m, 3 H) , 4,8 (b. 1 H), 5.1 ( , 4 H), 7.05 (m, 2 H), 7.2 (m, 3 H) , 7.35 (m, 10 H) ; mass spectrum, m/e 447(M+H) . The above compound was coupled in 41% yield using l-(3-dimethyl-aminopropyl)-3-ethyl carbodiimide hydrochloride to N-Boc-(N-Methyl)Phenylalanyl- Lysyl(N-epsilon-Boc)-Prolyl-{ (2R)-2-.Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoic acid} which was prepared by methodology described in Example 322: F.AB+ MS: (M+H) + =1339. The Cbz group and benzyl ester were cleaved hydrogenitically: Ram, S.; Ehrenkaufer, R. E. 13^ Synthesis 1988, 91-95. Guanidination of the delta amine of the ornithine residue was accomplished according to the procedure of Salvadori, S.; Sarto, G. P.; Tomatis, R. Eur. J. Med. Chem. -Chim. Ther. 1983, 18, 489-493. The Boc groups were removed with 50% trifluoroacetic acid in methylene chloride to supply the title compounds. Besides the diastereomeric pair created by coupling of racemic 2-benzyl- ornithine, racemization occurred at the adjacent residue. The four compounds; Examples 378, 379, 363, and 364; were separated and purified by HPLC as described in Example 2. FAB + MS: (M+H) + =957 PheMe(0.79), Lys (0.98), Pro (1.02), Cha (1.85) Example 379 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-1 (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- ! (R/S)-2-Benzyl-arginyl}-OH The preparation of this compound is described in Example 378. FAB + MS: (M+H)+=957 PheMe(0.79), Lys (0.99), Pro (1.01), Cha (1.88) Example 380 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Glycyl-1 (2R)- 2-.Amino-3-cyclohexylpropanoyl}-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH FAB+ MS: (M+H)+=909 Amino Acid Anal. : Gly (0.99), Phe (0.95), Lys (0.98), Arg (1.08) Example 381 i Z-i H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DOrnithyl-OH FAB + MS: (M+H)+=898 Example 382 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-DPhenylalanyl-{ (R/S)-2-Benzyl-arginyl}- OH This compound was prepared in analogy to Example 378 FAB + MS: (M+H) + =951 Amino Acid Anal. : PheMe (0.82), Lys (0.99), Pro (1.03), Cha (0.94), Phe (1.04) Example 383 (N-Methyl)Phenylalany1-Lysyl-Proly1-DPhenylalanyl- Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =855 Example 384 H-Phenylalanyl-Lysyl-DAlanyl-{ (2S)-2-Amino-3- cyclohex lpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H) + =827 Example 385 H-{ (2R/S) (m-Fluoro)Phenylalanyl}-Lysyl-Prolyl-{ (2R)-2-inino- 3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =865 Example 386 (N-Methyl)Prolyl-Lysyl-Prolyl-( (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H)+-817 Amino Acid Anal. : Lys (0.98), Pro (1.17), Cha (2.00), Arg (1.02) Example 387 (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-!3-(2'-Thienyl)alanyl}-DArginyl-OH FAB+ MS: (M+H)+=867 Example 388 H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-Leucyl-D.Arginyl-OH FAB + MS: (M+H)+=943 Amino Acid Anal.: Pro (1.04), Phe (2.13), Cha (0.89), Lys (0.96), Arg (0.97) or Pro (1.01), Phe (1.94), Cha (01.01), Lys (0.93), Arg (1.12) Example 389 H-Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)-Prolyl-{ (2R) 2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB+ MS: (M+H)+=943 Amino Acid Anal. : Pro (0.82), Phe (2.03), Cha (1.04), Lys (1.02), Arg (1.10) Example 390 H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- Leucyl-DNorleucyl-OH F.AB + MS: (M+H)+-897 Example 391 /3G> H-Lysyl-Phenylalanyl-DAlanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH FAB + MS: (M+H)+=827 Example 392 (N-Benzyl)DProlyl-Lysyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH F.AB+ MS : (M+H) + =893 Amino Acid Anal. : Lys (0.93), Pro (1.24), Cha (2.14), Arg (1.07) Example 393 H-{3-(2'-Thienyl)alanyl}-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH FAB + MS: (M+H) + =853 The foregoing examples are merely illustrative of the invention and are not intended to limit the invention to the disclosed compounds. Variations and changes which are obvious to one skilled in the art are intended to be within the scope and nature of the invention which is defined in the appended claims.

Claims: WE CLAIM; 1. .An anaphylotoxin activity modulating compound of the formula: A-B-D-E-G-J-L-M-Q and the pharmaceutically acceptable salts, esters, or amides thereof wherein the groups A through Q have the values: A is R3.-R2-R3; B is selected from R 4 -R 5 -R 6 , R 35 and R 37 ; D is selected from R 7 -R 8 -R 9 and R 35 ,. E is selected from R10-R 11 -R 12 and R35,. G is selected from R 13 -R 14 -R 15 and R 35 ,. J is selected from Ri6~Ri7""Ri8 and R35,. L is selected from Ri9~R 2 0~R 2 i and R 3 5,. M is selected from a valence bond, 2 2 -R 2 3-R 24 and R35; Q is R25-R26-R27; wherein (a) Ri is selected from the group consisting of aryl, lower alkyl, arylalkyl, and hydrogen; (b) R2 is selected from the group consisting of >CRg9Rioo and oxygen, with the proviso that when R2 is oxygen, Ri is aryl, lower alkyl, or arylalkyl; (c) R3 is selected from the group consisting of >C=0 and >CH2, with the proviso that when R3 is >CH2 then R2 cannot be oxygen; (d) R is >NRχoι where R 1 01 is selected from the group consisting of hydrogen, lower alkyl, arylalkyl, and alkenyl; (e) R5 is selected from the group consisting of >CR20lR202, >NR203 and >C=CR205R206r existing in either the Z- or E-configuration, and substituted cyclopropyl of the formula (f) Re, R9, 12, R15, Ri8, ^21 and R24 are >C=0; (g) R7, Rio, R13, i6, R19, and R22 are >NH; (h) e is selected from the group consisting of CR2lO R 2ll, > R2l3 > =CR215-R216, existing in either the Z- or E-configuration, and substituted cyclopropyl of the formula (i) Ril is selected from the group consisting of >CR22θR221, >NR223, >C=CR225-R226. existing in either the Z- or ^-configuration, and substituted cyclopropyl of the formula (j) R 14 is selected from the group consisting of >CR23θR231 >NR233, >C=CR235-R236, existing in either the Z- or ^.-configuration, and ■3<ϊ substituted cyclopropyl of the formula (k) Rχ 7 is selected from the group consisting of >CR30iR302 >NR303/ >C=CR305R306, existing in either the Z- or E-configuration, and substituted cyclopropyl of the formula (1) R 20 is selected from the group consisting of >CR3ioR3ll, >C=CR3i5R3i6, existing in either the Z- or E-configuration, and substituted cyclopropyl of the formula (m) R 23 is selected from the group consisting of >CR32θR32i , existing in either the Z- or E-configuration, and substituted cyclopropyl of the formula (P) R 25 s selected from the group consisting of >0 and >NRχo9 where R 109 is selected from the group consisting of hydrogen, lower alkyl, and arylalkyl; ( R 26 is selected from the group consisting of m hydrogen, lower alkyl, arylalkyl and >NRno where Rno is selected from the group consisting of hydrogen, lower alkyl, aryl, and arylalkyl, with the provisos that (i) when R2 5 is >0 then R 26 is lower alkyl (ii) when R 26 is hydrogen, lower alkyl, or arylalkyl, then R 2 7 is absent; (r) R27 is selected from hydrogen and aryl; (w) R 35 is where f is an integer of 0 to 2, X is >C=0 and R is selected from hydrogen and lower alkyl, with the provisos that (i) when f is 0, X is at C-2 and R is at C-3 or C-4; (ii) when f is 1, X is at C-2 and R is at C-3, C-4 or C-5 and C-3,4 are saturated or unsaturated; (iii) when f is 2, X is at C-2, C-3 or C-4 and R is at C-2, C-3, N ) C-4, C-5 or C-6 when the position is unoccupied by X and C-3,4 or C-4,5 are saturated or unsaturated; (y ) R37 is 10 wherein h is 1 and j is 0 or 1; (aa) Ri and R 2 , taken together, optionally represent a group selected from aryl, or hydrogen; 15 (ab) R26 and 27/ taken together, optionally represent hydrogen, with the proviso that when R25 is >0, then R26 and R27, taken together, represent hydrogen, lower alkyl, or 20 arylalkyl; (ac) Ri, 2 and R3, taken together, optionally represent a group selected from the group consisting of lower alkyl, 25 arylalkyl, alkenyl, hydrogen, and an N- terminal protecting group; ( ad ) R205, R206, R215, 216, R225, R226, 1-4Λ R235/ R236, R305r and R 306 are independently selected from the group consisting of hydrogen; lower alkyl; aryl; arylalkyl, wherein arylalkyl is excluded from R305 and R3O6 when i9-R20~R2l represents an L-arginyl residue; (cycloalkyl)alkyl; amidoalkyl, wherein benzoyl amides and their heterocyclic variants are excluded from R305 and R306 when R19-R20-R21 represents an L-arginyl residue; (carboxyamido)alkyl, wherein aniline amides and their heterocyclic variants are excluded from R305 and R306 when Ri9-R20~R21 represents an L-arginyl residue; ureidoalkyl, and (heterocyclic)alkyl, wherein when Ri9-R20~ R 2i represents an L-arginyl residue, then the heterocycle at from R305 and R306 can only be separated by one methylene unit from the alpha-carbon; (ae) R315 and R316 are independently selected from the group consisting of hydrogen, lower alkyl, aryl, arylalkyl, wherein arylalkyl is excluded when R22"~R23~ R 24 represents an L- arginyl residue, and (cycloalkyl)alkyl; (af ) R99, R202, 2ll 22l R231, R302, 311, and R321 are independently selected from the group consisting of hydrogen, lower alkyl and arylalkyl, wherein for R302 and R3 11 , arylalkyl is excluded when Ri9-R20~ 2l ° r R 22~ 23" 24 respectively represent an L-arginyl residue; (ag) Rioo is selected from hydrogen or lower alkyl; 5 (ah) R201 is selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl, amidoalkyl, hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl, 10 (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl, (thioalkoxy)alkyl, and sulfhydrylalkyl; ( ai ) R203, R213, 223 R233, and R303 are 15 independently selected from the group consisting of hydrogen; lower alkyl; alkenyl; arylalkyl, wherein arylalkyl is limited to benzyl at R303 when i 9 - 20~ R 2 1 represents an L-arginyl residue; (cycloalkyl)alkyl, 20 aminoalkyl, wherein aryl and arylalkyl amines are excluded from R303 when R19-R20-R21 represents an L-arginyl residue; amidoalkyl, wherein benzoyl amides and their heterocyclic variants are excluded from R 303 25 when Ri9-R 2 0~ R 21 represents an L-arginyl residue, hydroxyalkyl; guanidinoalkyl; carboxyalkyl; (carboxyamido)alkyl, wherein aniline amides and their heterocyclic variants are excluded from R 303 when 30 R l 9-R 20 ~ R 2l represents an L-arginyl residue; (carboxyhydrazino)alkyl; ureidoalkyl; l^v (heterocyclic)alkyl, wherein when Rιg-R20~R2l represents an L-arginyl residue, then the heterocycle at R 303 can only be separated by one methylene unit from the alpha-carbon; (thioalkoxy)alkyl; and sulfhydrylalkyl with the proviso that none of R203, R213, R223 R233r or R 303 may be a vinyl group or have a heteroatom directly attached to the nitrogen or separated from it by one methylene unit; (aj) R210 is selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl, amidoalkyl, amidinoalkyl, hydroxyalkyl, carboxyalkyl, (carboxyamido)alkyl, ureidoalkyl, (carboxyhydrazino)alkyl, (heterocyclic)alkyl, (thioalkoxy)alkyl, sulfhydrylalkyl, and guanidinoalkyl; (ak) R220 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl, amidoalkyl, hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl, (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl, (thioalkoxy)alkyl, and sulfhydrylalkyl; (al) R 2 3 0 is independently selected from the group consisting of hydrogen, lower alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl, amidoalkyl, hydroxyalkyl. IMS guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl, (carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl, (thioalkoxy)alkyl, and sulfhydrylalkyl; 5 (am) R30 1 is independently selected from the group consisting of hydrogen; lower alkyl; alkenyl; aryl; arylalkyl, wherein arylalkyl is limited to benzyl, when i9-R 2 0~R2i represents an L- 10 arginyl residue; (cycloalkyl)alkyl; aminoalkyl, wherein aryl and arylalkyl amines are excluded when Ri9-R 20 " R 2l represents an L- arginyl residue; amidoalkyl, wherein benzoyl amides and their heterocyclic variants are 15 excluded when Rιg-R 2 0~R2i represents an L- arginyl residue; hydroxyalkyl; guanidinoalkyl; carboxyalkyl; (carboxyamido) lkyl, wherein aniline amides of aspartyl residues and heterocyclic 20 variants are excluded when R19-R20-R2 1 represents an L-arginyl residue; (carboxyhydrazino)alkyl; ureidoalkyl; (heterocyclic)alkyl, wherein when R 19 - R 20 ~R2 l represents an L-arginyl residue, then 25 the heterocycle can only be separated by one methylene unit from the alpha-carbon; (thioalkoxy)alkyl, and sulfhydrylalkyl; (an) R 304 is independently selected from the group 30 consisting of hydrogen; lower alkyl; alkenyl; J C aryl, arylalkyl, wherein arylalkyl is excluded when Ri9-R20~ R 2 l represents an L- arginyl residue; (cycloalkyl)alkyl; aminoalkyl, wherein aryl and arylalkyl amines are excluded when i 9 ~R 20 ~ 2 i represents an L- arginyl residue; amidoalkyl, wherein benzoyl amides and their heterocyclic variants are excluded when Ri9-R 2 0~ 2 l represents an L- arginyl residue; hydroxyalkyl; guanidinoalkyl; carboxyalkyl; (carboxyamido)alkyl, wherein aniline amides and heterocyclic variants are excluded when R19-R20-R21 represents an L-arginyl residue; (carboxyhydrazino)alkyl; ureidoalkyl; (heterocyclic)alkyl, wherein (heterocyclic)alkyl is excluded when Ri9~R20~ R21 represents an L-arginyl residue; (thioalkoxy)alkyl; and sulfhydrylalkyl; (ao) R30 7 and R 317 are independently selected from hydrogen; lower alkyl; aryl and arylalkyl, wherein arylalkyl is excluded for R 30 7 and R317 when Ri9-R20" 2l and R22-R23-R2 respectively represent an L-arginyl residue. (ap) R 31 0 is independently selected from the group consisting of hydrogen; lower alkyl; alkenyl; aryl; arylalkyl, wherein arylalkyl is limited to benzyl when R22~R23~ 2 4 represents an L- arginyl residue; (cycloalkyl)alkyl; aminoalkyl, aryl and arylalkyl amines are excluded when R22~R23~R 2 4 represents an L- W arginyl residue; amidoalkyl, wherein benzoyl amides and their heterocyclic variants are excluded, when R 2 2~R 23 ~ 24 represents an L- arginyl residue; hydroxyalkyl; 5 guanidinoalkyl; (carboxyamido)alkyl, wherein aniline amides of aspartyl residues and heterocyclic variants are excluded when R2 2 ~ R23- 2 represents an L-arginyl residue; (carboxyhydrazino)alkyl; ureidoalkyl; 10 (heterocyclic)alkyl, wherein when R 22 ~ 23-R2 represents an L-arginyl residue, then the heterocycle can only be separated by one methylene unit from the alpha-carbon; and sulfhydrylalkyl; 15 (aq) R312 is independently selected from the group consisting of hydrogen; lower alkyl; alkenyl; aryl; arylalkyl, wherein arylalkyl is excluded when R 22 ~ R 2 3~R24 represents an L- 20 arginyl residue; (cycloalkyl)alkyl; aminoalkyl, wherein aryl and arylalkyl amines are excluded when R 2 2- 23-R24 represents an L-arginyl residue; amidoalkyl, wherein benzoyl amides and their heterocyclic 25 variants are excluded when R22-R23-R2 4 represents an L-arginyl residue; hydroxyalkyl; guanidinoalkyl; carboxyalkyl; (carboxyamido)alkyl, wherein aniline amides and heterocyclic variants are excluded when 30 2 2~R 2 3~R 24 represents an L-arginyl residue; (carboxyhydrazino)alkyl; ureidoalkyl; (heterocyclic) lkyl, wherein (heterocyclic)alkyl is excluded when R22~R23~ R2 4 represents an L-arginyl residue; (thioalkoxy)alkyl; and sulfhydrylalkyl; (ar) R320 is selected from the group consisting of hydrogen, lower alkyl, arylalkyl, alkenyl, (cycloalkyl)alkyl, aminoalkyl, and guanidinoalkyl; (as) R325 and R326 are independently selected from the group consisting of hydrogen, lower alkyl, aryl, arylalkyl, and (cycloalkyl)alkyl; ( at ) R201 and R202r R210 and R211, R220 and 22ir R230 and R231, R301 and R302, R310 and R311, and R320 and R321 each pair taken together, independently may optionally represent -(CH2) 2 ~ where z is an integer of from 2 to 6; (au) R201 and R202, R210 and R211, R220 and R22i R230 and R231, R301 and R302/ R310 and _ R311, and R320 and R321, each pair taken together, independently may optionally represent -CH2C6H 4 CH2- where the two methylene chains are in an ortho configuration; all of the foregoing with the provisos that (i) when more than one sulfhydrylalkyl is present in the compound, the compound exists in the mi oxidized disulfide form producing a cyclic molecule, or the two sulfhydryl moieties are connected by a C 2 to Cβ alkylene chain and (ii) when the compound contains a free amino group and carboxyl group, they can be cyclized to give the corresponding lactam. 2. A compound as defined by Claim 1 wherein R5 is selected from >C 2oιR202; > R203; existing in the Z- or ^-configuration; and substituted cyclopropyl of the formula "202; where R 201 is selected from aryl or arylalkyl; R 2 0 2 and R2 05 are selected from hydrogen or lower alkyl; R203 is arylalkyl; and R 206 selected from aryl or arylalkyl. 3. A compound as defined by Claim 1 wherein Re is selected from the group consisting of >CR 2 io 2iι» >NR 2 i3; >C=CR2i5R2i6' existing in either the Z- or E configuration; y__ *- ° and substituted cyclopropyl of the formula R 2iι; wherein | 50 R 210 is selected from the group consisting of arylalkyl; aminoalkyl; guanidinoalkyl; and lower alkyl; R 21 1 and R 215 is selected from hydrogen or lower alkyl; R 2 13 is selected from the group consisting of arylalkyl; aminoalkyl; guanidinoalkyl; and lower alkyl; with the proviso that R 213 may not have a heteroatom directly attached to the nitrogen or separated from it by one methylene unit; and R 21 6 is selected from arylalkyl or lower alkyl. 4. A compound as defined by Claim 1 wherein R 17 is selected from the group consisting of >CR3oiR302 >NR303; existing in either the Z- or E configuration; and substituted cyclopropyl of the formula wherein R 301 i selected from the group consisting of lower alkyl; arylalkyl, wherein arylalkyl is limited to benzyl when Rιg-R 20 ~ 21 represents an L-arginyl residue; and (cycloalkyl)alkyl; R 302 f R305, and R 30 7 are selected from hydrogen or lower alkyl; R 303 is selected from the group consisting of hydrogen; lower alkyl; (cycloalkyl)alkyl; and arylalkyl , wherein arylalkyl is limited to benzyl when Ri9-R 2 0~ R 2l represents an L- arginyl residue; and R30 4 is selected from the group consisting of lower alkyl; aryl, arylalkyl, wherein arylalkyl is excluded when R 1 9-R 2 0-R 21 represents an L- arginine residue; and (cycloalkyl)alkyl; R3O6 is selected from aryl or arylalkyl, wherein arylalkyl is excluded when i 9 - 20~ R 2 1 represents an L-arginyl residue; lower alkyl; hydrogen; and (cycloalkyl)alkyl. 5. A compound as defined by Claim 1 wherein R 20 is selected from the group consisting of >CR3ioR 3 iι; >C=CR3i5R3i6, existing in either the Z- or E configuration; and substituted cyclopropyl of the formula wherein R 310 is selected from the group consisting of arylalkyl and guanidinoalkyl, wherein arylalkyl is limited to benzyl when R 2 2~ R 2 3~ R 4 represents an L-arginyl residue; R 31I ' R 315 , and R 31 7 are selected from hydrogen or lower alkyl; / 52- R 312 is selected from the group consisting of aryl, arylalkyl, and guanidinoalkyl, wherein arylalkyl is excluded when R22-R23-R24 represents an L-arginine residue; and R 316 is selected from arylalkyl and aryl, wherein arylalkyl is excluded when R 2 2~ R 23-R24 represents an L-arginyl residue. 6. A compound as defined by Claim 1 wherein when G and L are alpha amino acid residues, the preferred chirality of R 14 and R 20 is of the D- or unnatural configuration. 7. A compound as defined by Claim 1 wherein R4, R7, Rio, R 13, R 16, Rl9, and R22 are >NH; or R4, R7, Rio, Ri6, R 1 9, and R 22 are >NH and E is R 35 . 8. A compound as defined by Claim 1 wherein R 1 -R 2 -R 3 taken together is independently selected from hydrogen, lower alkyl or acetyl. 9. A compound as defined by Claim 1 wherein Rβ, R9, R12, R 15 , Ri8, R 2 i and R24 are independently selected from >C=0. 10. A compound as defined by Claim 1 selected from the group consisting of: H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DLeucyl-DArginyl-OH; 133 H-(p-Iodo)Phenylalanyl-Lysyl-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-( (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl- DAlanyl-Arginyl-OH; H-Phenylalanyl-Lysyl-Prolyl-DLeucyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-Leucyl-DPhenylalanyl-Arginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DTyrosyl-{ (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Prolyl-DPhenylalanyl-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Alanyl-{ (2S)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DLeucyl-Arginyl-OH; H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl- DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-D(1-Naphthylalanyl)- Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-DPhenylalanyl-! (2S)-2- Amino-3-cyclohexylpropanoyl}-DArginyl-OH; and H-Phenylalanyl-Lysyl-Alanyl-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}-Leucyl- DNorleucyl-OH. 11. A compound as defined by Claim 1 wherein R 13 -R 14 -R 1 5 taken together is ! (2R)-2-amino-3-cyclohexylpropanoyl} is selected from the group consisting of: (N-Methyl)Phenylalanyl-Lysyl-Tyrosyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; SM (N-Methyl)Phenylalanyl-Lysyl-Glutamyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl) henylalany1-Lysyl-Lysyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-1 (2R)-2-Amino-3-cyclo- hexylpropanoyl}-(1-Naphthylalanyl)-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-! (2R/S) -2-Amino-5-phenyl- pentanoyl}-! (2R)-2-Amino-3-cyclohex lpropanoyl}-Phenyl¬ alanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Tryptophanyl-DArginyl-OH; (N-Methyl)Phenylalany1-Lysyl-Arginyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; N-Acetyl-! (Z)-2-Amino-3-phenyl-2-propenoyl}-Lysyl-Prolyl- ! (2R)-2-?^mino-3-cyclohexylpropanoyl}-Phenylalanyl- DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-{ (2R) -2-Amino-3-cyclo- hexylpropanoyl}-Phenylalany1-DPhenylalany1-OH; (N-Methyl)Phenylalanyl-Lysyl-Tryptophanyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Alanyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; H-Phenylalanyl-Lysyl-Azaglycyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Norleucyl-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-Phenylalanyl-{ (R)-Phenylglycinyl}-OH; (N-Methyl)Phenylalanyl-Lysyl-! (2S)-2-Amino-4-pentenoyl}~ ! (2R)-2-Amino-3-cyclohexylpropanoyl}-Phenylalanyl- DArginyl-OH; (N-Methyl) (2R/S) (3-F)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino- 3-cyclohexylpropanoyl}-Phenylalanyl-DArginyl-OH; and H-Phenylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-Leucyl-DArginyl-OH. 12. A compound as defined by Claim 1 wherein R 13 -R 14 -R 15 taken together is ! (2R)-2-amino-3-cyclohexylpropanoyl} and Rl6~Rl7~Rl8 taken together is ! (2S)-2-amino-3-cyclohexyl- propanoyl} is selected from the group consisting of: H-Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; H-{ (R/S)-t-Butylalanyl-Lysyl-Prolyl-{ (2R)-2-Amino-3-cyclo- hexylpropanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; (N-Methyl)Phenylalanyl-Ornithyl-Prolyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; (N,N-Dimethyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-.Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Arginyl-! (2R)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; H-Phenylalanyl-Arginyl-Prolyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; I S (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-.Amino-3-cyclo- hexylpropanoyl}-(2-Naphthylalanyl)-DArginyl-OH; H-Phenylalanyl-Lysyl-Lysyl-! (2R)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; N-Acetyl-! (IR/S) (2R/S) ((Z)-l-Amino-2-phenylcyclopropyl)-1- carbonyl}-Lysyl-Alany1-{ (2R)-2-Amino-3-cyclohexyl¬ propanoyl}-! (2S)-2-Amino-3-cyclohex lpropanoyl}- Arginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-! (2S)-2-.Amino-3-cyclohexylpropanoyl}- DTryptophanyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-N-(Me) (Benzyl) ; H-Phenylalanyl-Ornithyl-Prolyl-! (2R)-2-Amino-3-cyclohexyl¬ propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; H-Phenylalanyl-Lysyl-Phenylalanyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; N-Acetyl-Phenylalanyl-Lysyl-Alanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Leucyl-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-{ (2S)-2-Amino-3-cyclohexylpropanoyl}- DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Alanyl-! (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; 151 (N-Methyl)Phenylglycyl-Lysyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl-Prolyl-! (2R)-2-Amino-3-cyclo- hexylpropanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH; (N-Methyl)Phenylalanyl-Norleucyl-Prolyl-{ (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-.Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Arginyl-! (2R)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- DAlanyl-OH; (N-Methyl)Phenylalany1-Lysyl-Tyrosy1-1 (2R)-2-Amino-3- cyclohexylpropanoyl}-! (2S)-2-.Amino-3-cyclohexyl- propanoyl}-DArginyl-OH; (N-Methyl)Phenylalanyl-Lysyl(N-epsilon-trifluoroacetyl)- Prolyl-1 (2R)-2-Amino-3-cyclohexylpropanoyl}-! (2S)-2- Amino-3-cyclohexylpropanoyl}-DArginyl-OH; H-Phenylalanyl-Lysyl-Alany1-{ (2R)-2-Amino-3-cyclohexyl- propanoyl}-! (2S)-2-Amino-3-cyclohexylpropanoyl}- D.Arginyl-OH; and (N-Benzyl)DProlyl-Lysyl-Prolyl-l (2R)-2-Amino-3- cyclohexyl-propanoyl}-! (2S)-2-Amino-3- cyclohexylpropanoyl}-DArginyl-OH. 13. A method for modulating anaphylatoxin activity in a mammal in need of such treatment, comprising administering to the mammal a therapeutically effective amount of a compound of Claim 1. 14. An anaphylatoxin modulating composition comprising a pharmaceutical carrier and a therapeutically effective amount of a compound of claim 1.

Inventors: KAWAI MEGUMI, LULY JAY R, OR YAT SUN, WAGNER ROLF, WIEDEMAN PAUL E, KAWAI, MEGUMI, LULY, JAY, R., OR, YAT, SUN, WAGNER, ROLF, WIEDEMAN, PAUL, E.
Applicants: ABBOTT LAB, ABBOTT LABORATORIES
Application year: 1991
Main classification: C07K5
IPC codes: A61K38, A61P37, C07K5, C07K7, C07K14