Pharmaceutical composition for treating pain associated with herpes-zoster and post-herpetic neuralgia by topical application of local anesthetics

Abstract: A method is offered for reducing the pain associated with herpes-zoster and post-herpetic neuralgia. The method consists of administering a composition incorporating a transdermal delivery system for the administration of local anesthetic to areas of the body afflicted by herpes-zoster and post-herpetic neuralgia enclosed with an occlusive dressing or a plaster dressing.

Description: Technical field The subject of this application concerns pharmaceutical composition for the treatment of pain associated with herpes-zoster and post-herpetic neuralgia. Background The acute neuralgia produced by recrudescence of latent varicella-zoster virus (familiarly known as chicken pox virus) is called herpes-zoster, or "shingles". Reactivation of the latent virus in a dorsal root ganglion results in the transport of live virus along the associated sensory nerves (dermatome). In addition to severe pain in the distribution of affected nerves, herpes zoster is also associated with complications such as myelitis, stroke, ocular damage, skin damage, and, most commonly, post-herpetic neuralgia - defined as pain that persists in the involved dermatome for more than 1 month after healing of the skin lesions. Over 50% of people over age 60 can expect to be afflicted with PHN. The disorder resolves spontaneously within 1 year in most cases, but in some the pain persists for life. Pain management in both herpes zoster and post-herpetic neuralgia is unsatisfactory. Non-steroidal anti-inflammatory medications and opiates are often of little benefit. The only drug with proven effectiveness in a controlled study is the tricyclic antidepressant amitripyline. This drug has multiple effects that are not well tolerated by elderly patients, and pain relief is incomplete. Other medications - anticonvulsants (eg, carbamazepine) and neuroleptics (eg, chlorprothixene) - are widely used but have not proved to be effective. Several topical preparations, including salicylate poultices, ethyl chloride spray, idoxurine (an antiviral agent) in DMSO, and others have been anecdotally reported to be effective. Local anesthetics, such as lidocaine, have been administered parenterally to relieve the pain of herpes zoster and post-herpetic neuralgia: as regional sympathetic blocks, as peripheral nerve blocks, by epidural infusion, and by direct subcutaneous infiltration, and intravenously. However, topical application of local anesthetics is not a presently recognized method of pain associated with herpes zoster and post-herpetic neuralgia. Relevant Literature The following are representative of the medical literature pertaining to management of post-herpetic neuralgia and herpes zoster: King RB, in Pain 1988;33:73-78, describes the use of an aspirin/chloroform mixture to treat post-herpetic neuralgia and herpes zoster Dan K et al, in Advances in Pain Research and Therapy vol 9, Field et al (editors), Raven Press, New York (1985), pages 831-838, describe the use of nerve block to treat herpetic pain Watson CP et al, in Neurology 1982;32:671-673, describe the use of amitriptyline for treatment of post-herpetic neuralgia. Colding A, in Proc R Soc Med 1971;66:541-543, describes the use of local anesthetics to treat herpetic pain. Secunda L. et al., in N Engl J Med 1941;224:501-503, describe the treatment of herpetic pain through cutaneous infiltration of local anesthetics. Hallen B. et al., in Anesthesiology 1982;57:340-342, describe the use of lidocaine-prilocaine cream to reduce the pain associated with bladder catheter insertion. Luben HM et al., in Am J Dis Chil 1974;128:92-194, describe the use of a 30 % lidocaine patch for anesthesia in minor surgery. Russo J. et al., in Am J Hosp Pharm 1980;37:843-847, compare the effectiveness of different methods of lidocaine administration. Sarpotdar P. and Zatz J., in J. Pharm Sciences 986;75:176-181 (title) Evaluation of Penetration Enhancement of Lidocaine by Nonionic Surpitants through Hairless Mouse Skin In Vitro. Reiz GMEE and Reiz SLA, in Acta Anaesth Scand 982;26:596-598 describe a topical anaesthetic compound. Mollgaard B. and Hoelgaard A., in Acta Pharm Suec 1983;20:43-450 describe drug permeation formulations. Vaughn C., in Cosmetics and Toiletriest 1988;103:47-68 describes cohesive energies of compounds for determining solubility and miscibility. Milligan K.A. et al., in British Medical Journal 1989;298:253 discloses treatment of PHN with an eutectic mixture of lidocaine (lignocaine and prilocaine) as a cream under occlusive conditions. SUMMARY OF THE INVENTION A pharmaceutical composition for reducing the pain of herpes-zoster and post-herpetic neuralgia is provided. The pharmaceutical composition of the invention comprises an effective amount of lidocaine as the sole active ingredient in a physiologically acceptable vehicle of transdermal penetration comprising a gel of a polyol and a gelling agent and an occlusive cover, or in a plaster with said lidocaine dissolved in the adhesive of said plaster for applying the composition to the skin at the site of pain. The composition according to the invention provides pain relief for significantly longer periods of time than currently used compositions and avoids the harmful effects associated with the use of other less effective or completely ineffective pharmaceutical compositions. Local anesthetics have the property of abolishing pain sensation at the site of application or injection. The compound used for management of pain due to herpes zoster and post-herpetic neuralgia may contain any of the local anesthetics now in use or combinations of these drugs. The drugs that make up one group of local anesthetics which find use in this invention have a structure consisting of a lipophilic group - usually armatic (eg, a benzene ring derivative) - connected by an intermediate chain - usually an amide, ester, or ether linkage - to an ionizable group - usually a protonated tertiary amine salt. Illustrative local anesthetics are lidocaine, prilocaine, mepivacaine, bupivacaine, etiocaine, benzocaine, procaine, and cocaine, which may be used individually or in combination. The preferred local anesthetic for transdermal infiltration is lidocaine as the chloride salt in a physiological acceptable solution. The local anesthetic present in the gel and plaster formulations is in base form or as a salt. The base in sufficient amounts will penetrate the skin to relieve the pain of herpes zoster and post herpetic-neuralgia. Depending on the mode of administration, anesthetic concentrations will generally be in the range of about 5-50%. For gels, the concentration will vary from about 5% to 20% - usually 5-10%; for plasters, the concentration may range from 1% up to 20%. The compound used for the treatment of pain associated with post-herpetic neuralgia and herpes zoster contains a vehicle for the purpose of increasing the effectiveness of transdermal delivery. The formulations vary depending on the manner of administration. When a gel is used as a vehicle for enhancing transdermal delivery, the compounds employed (usually anhydrous compounds) include solvents such as polyols, particularly glycols (propylene glycol, hexylene glycol, dipropylene glycol, polyethylene glycol, tripropylene glycol, triethylene glycol, butylene glycol, and hexanetriol) - individually or in combination. These compounds are present in concentrations sufficient to promote transdermal delivery of the local anesthetic, usually present in concentrations of 70-90% - most commonly 75-85%. The gel is used to facilitate application to the skin. Illustrative gelling agents are hydroxypropylcellulose acetate, polyethylene glycols, carbomer 940 (diisopropylpropanolamine-neutralized polyacrylate), etc. The gelling agent used will be in concentrations of about 0.1-5%. Nonionic surfactants will also usually be employed - polysorbate esters and ethers, sorbitol esters and ethers, etc. - in concentration ranging from 2% to 20% also serving as cosolvents and skin penetration enhancers. The vehicle may also contain other physiologically acceptable excipients such as fragrances, dyes, emulsifiers, buffers, cooling agents (eg, menthol). The excipients are present in conventional amounts ranging from about 0.001% to 5% - most commonly 0.001-2% but not to exceed a total of 10%. The major ingredients of the gel vehicle should have a solubility parameter (see Vaughn, supra) in the range of about 9-13.5, preferably 10-12; each of the major components will usually have a solubility parameter in the range of about 9-14, preferably about 9.5-12.5 (as an average of all of the components). In some instances, one component may serve more than one function. Salicylate compounds such as methyl salicylate or glycol salicylate may act both as solvents and as analgesics. There is therefore some flexibility in preparing the formulation, though it should provide a reasonable rate of penetration of the drug through the unit area of skin over a period of about 4-12 hours. The local anesthetic compound may be present as an independent entity or as a salt of an analgesic or nonsteroidal anti-inflammatory drug. Salts of salicylic acid, acetylsalicylic acid (aspirin), indomethacin, and ketoprofen are suitable for topical transdermal delivery. Salts of anesthetic and analgesic may be prepared, eg lidocaine salicylate. Analgesic drugs in concentrations of 1-10% are usually sufficient to reduce pain. Other methods of application include aerosols, in which a gas is combined with the vehicle, and plasters. In the case of plasters, the covering is substantially impermeable to the compound and to other fluids. For the plaster, the covering may be composed of polyvinyl chloride, Saran Wrap, polyethylene, synthetic rubber, woven or nonwoven polyethylene fabric, etc. The drug is dissolved in the adhesive with the aid of methyl salicylate, glycol salicylate, or other solvent. The invention is also directed to the use of a pharmaceutical composition as disclosed, for the manufacture of a preparation having a long term effect for the treatment of postherpetic neuralgia. The data on the following pages are offered by way of illustration and not by way of limitation. EXPERIMENTAL MATERIALS AND METHODS Patient Population Claims for the effectiveness of the invention are supported by the results of a study undertaken by Rowbotham MC and Fields HL, Department of Neurology, School of Medicine, University of California, San Francisco. This study entitled " Topical Lidocaine Reduces Pain in Post-Herpetic Neuralgia", presents data from experience with 11 patients who had well-established post-herpetic neuralgia (pain present for more than 3 months after healing of the rash of herpes zoster); well-demarcated areas of skin with marked allodynia (pain resulting from a nonnoxious stimulus to normal skin) from light stroking with a cotton wisp; and no medical contraindications to the use of local anesthetics. Six women and five men participated in the study. The average was 70 years. Six patients had post-herpetic neuralgia that included the ophthalmic division of the trigeminal nerve, and five had post-herpetic neuralgia located in thoracic dermatomes. The duration of pain ranged from 3 months to 12 years. All subjects except two were in good general health. One patient had multiple cardiovascular problems, and another had widespread multiple myeloma. In all cases, post-herpetic neuralgia was the only significant pain problem during the period of the study. Formulation of Anesthetic Containing Compound The local anesthetic preparation used in the study consisted of a 10% lidocaine in a gel vehicle. The vehicle consisted of 12% polysorbate-20, 0.9% carbomer 940, 0.8% diisopropanolamine, and 76.3% propylene glycol. Lidocaine gel was applied to the skin, and the area was covered with plastic food wrap (Saran Wrap) and the edges taped with 3M Micropore Adhesive Tape, taking care not to apply tape to hypersensitive skin. In a further refinement for thoracic post-herpetic neuralgia, an adhesive plaster sheet (10 X 14 cm), with interwoven polyethylene fabric backing and 14 grams of adhesive containing 3.58% lidocaine and 2% methylsalicylate, was applied to affected areas of the backs of patients. The plaster formulation was found to be as effective as the occlusive dressing formulation in relieving pain associated with thoracic post-herpetic neuralgia. Application of Compound For thoracic post-herpetic neuralgia, the dosage of lidocaine applied as gel ranged from 240 to 500 mg. Subjects with post-herpetic neuralgia involving trigeminal nerve were not treated in the same way. Instead, the gel provided was spread by the subject over areas of maximum pain and sensitivity on the forehead, temple, and scalp. The medication was not covered but was applied repeatedly to maintain contact. The dosage of lidocaine applied in this way ranged from 140 to 300 mg. Pain Measurement Pain was measured on the 100 mm pain VAS scale and a 100 mm pain relief VAS scale. The VAS (Visual Analog Scale) pain scale is defined by Littman GS et al in Clin Pharmacol Ther 1985;38:16-23. Pain levels were assessed every hour for 4 hours after lidocaine application. Blood pressures and pulse rates were recorded, and possible side effects were monitored. At 1 and 3 hours after lidocaine application, blood was drawn for determination of serum lidocaine levels. Results For the entire group of 11 subjects, pain VAS ratings declined steadily over the 4 hours of observation from a baseline mean of 35.5 mm +/- 25.4 mm to a low of 14.2 mm +/- 7.8 mm at 4 hours after application (P < 0.01). Pain relief VAS ratings increased steadily during the observation period from 39.3 mm +/- 39.9 mm at 1 hour after application to 59.6 mm +/- 25.5 mm at 4 hours after application (P < 0.01). Calculating the change in pain VAS scores from baseline for the observation period showed the largest decrease in pain score occurred at 3 hours after gel application. The decrease was 21.2 mm +/- 19.4 mm (P = 0.05). There were significant differences in the manner in which patients with thoracic post-herpetic neuralgia and those with trigeminal post-herpetic neuralgia responded to the topical lidocaine. The five subjects with thoracic post-herpetic neuralgia had highly significant changes in pain ratings, especially during the last 2 hours of observation, from a baseline mean of 44.2 mm +/- 21.6 mm to a low of 12.8 mm +/- 8.7 mm (P < 0.001). The results achieved with occlusive dressings and with the plaster formulation described below were equally good. Subjects with trigeminal post-herpetic neuralgia also demonstrated a decline in pain VAS scores, but the observed changes were not statistically significant. Analysis of pain relief also showed a difference in response between the two groups, but in both groups the mean peak pain relief ratings were greater than 50 mm. The greater pain relief experienced by the patients with thoracic post-herpetic neuralgia may be attributable to the enhancing effect of the occlusive covering and the transdermal penetration achieved with the plaster formulation. Subjects reported no adverse effects of topical lidocaine during the period of the study. Changes in blood pressure and pulse were not significant. At both 1 and 3 hours after application, serologic tests revealed measurable blood levels of lidocaine in all subjects, but the concentration in all cases was below 1 microgram per milliliter.

Claims: Claims for the following Contracting States : AT, BE, CH, DE, DK, FR, GB, IT, LI, LU, NL, SE Pharmaceutical composition comprising an effective amount of lidocaine as the sole active ingredient in a physiologically acceptable vehicle of transdermal penetration comprising a gel of a polyol and a gelling agent and an occlusive cover, or in a plaster with said lidocaine dissolved in the adhesive of said plaster for applying the composition to the skin at the site of pain. Composition according to claim 1, wherein the lidocaine concentration is ranging from about 5 to 20 % when said composition is a gel and from 1 to 20 % when said composition is incorporated into plaster. Composition according to anyone of claims 1 to 2, wherein the vehicle consists of propylene glycol in a concentration of about 70-90 %. Composition according to anyone of claims 1 to 3, wherein the gel consists of about 0.1-5% of a thickening agent. Composition according to anyone of claims 1 to 4, wherein the thickening agent is an amine-neutralized polyacrylate. Use of a composition as claimed in claims 1 to 5 for the manufacture of a preparation having a long term effect for the treatment of postherpetic neuralgia. Claims for the following Contracting States : ES, GR Method of making a pharmaceutical composition comprising mixing an effective amount of lidocaine as the sole active ingredient with a physiologically acceptable vehicle of transdermal penetration comprising a gel of a polyol and a gelling agent and an occlusive cover, or with a plaster with said lidocaine dissolved in the adhesive of said plaster for applying the composition to the skin at the site of pain. Method according to claim 1, wherein the lidocaine concentration is ranging from about 5 to 20 % when said composition is a gel and from 1 to 20 % when said composition is incorporated into plaster. Method according to anyone of claims 1 to 2, wherein the vehicle consists of propylene glycol in a cocentration of about 70-90 %. Method according to anyone of claims 1 to 3, wherein the gel consists of about 0.1-5% of a thickening agent. Method according to anyone of claims 1 to 4, wherein the thickening agent is an amine-neutralized polyacrylate. Use of a composition obtained by the method of any of claims 1 to 5 for the manufacture of a preparation having a long term effect for the treatment of postherpetic neuralgia.

Inventors: HIND HARRY, HIND, HARRY
Applicants: HIND HEALTH CARE INC, HIND HEALTH CARE, INC.
Application year: 1990
Main classification: A61L15
IPC codes: A61K31, A61K9, A61P25, A61K45, A61K47