Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which one of X and Y represents hydrogen and the other represents Z, where Z is a group in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises zero, one or two nitrogen atoms, Q being optionally C-substituted by a group R₁ selected from halogen, CN, OR₂, SR₂, N(R₂)₂, NHCOR₂, NHCOOCH₃, NHCOOC₂H₅, NHOR₂, N₃, NHNH₂, NO₂, COR₂, COR₃, C₂₋₄ alkenyl, C₂₋₄ alkynyl, cyclopropyl or C₁₋₂ alkyl optionally substituted with OR₂, N(R₂)₂, SR₂, CO₂R₂, CON(R₂)₂ or one, two or three halogen atoms, in which each R₂ is independently hydrogen or C₁₋₂ alkyl and R₃ is OR₂, NH₂ or NHR₂; r represents an integer of 2 or 3, s represents an integer of 1 or 2 and t represents 0 or 1; R a and R b each represent hydrogen or, when X is hydrogen, optionally together represent a bond; with the proviso that when Y is hydrogen s is 1.

Description: This invention relates to compounds having pharmaceutical activity, to a process for their preparation and their use as pharmaceuticals. EP-A-0261763, EP-A-0323864, EP-A-0307140 and EP-A-0287356 disclose certain non-aromatic 1-azabicyclic ring systems substituted by certain 5-membered aromatic heterocycles. A novel group of compounds has now been discovered which enhance acetylcholine function via an action at muscarinic receptors within the central nervous system and are therefore of potential use in the treatment and/or prophylaxis of dementia in mammals. According to the present invention, there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof: in which one of X and Y represents hydrogen and the other represents Z, where Z is a group in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises zero, one or two nitrogen atoms, Q being optionally C-substituted by a group R₁ selected from halogen, CN, OR₂, SR₂, N(R₂)₂, NHCOR₂, NHCOOCH₃, NHCOOC₂H₅, NHOR₂, N₃, NHNH₂, NO₂, COR₂, COR₃, C₂₋₄ alkenyl, C₂₋₄ alkynyl, cyclopropyl or C₁₋₂ alkyl optionally substituted with OR₂, N(R₂)₂, SR₂, CO₂R₂, CON(R₂)₂ or one, two or three halogen atoms, in which each R₂ is independently hydrogen or C₁₋₂ alkyl and R₃ is OR₂, NH₂ or NHR₂; r represents an integer of 2 or 3, s represents an integer of 1 or 2 and t represents 0 or 1; R a and R b each represent hydrogen or, when X is hydrogen, optionally together represent a bond; with the proviso that when Y is hydrogen s is 1. Certain compounds of formula (I) are capable of existing in a number of stereoisomeric forms including enantiomers. The invention extends to each of these stereoisomeric forms, and to mixtures thereof (including racemates). The different stereoisomeric forms may be separated one from the other by the usual methods, or any given isomer may be obtained by stereospecific or asymmetric synthesis. In compounds of formula (I) having two assymmetric centres where Y is other than hydrogen and R a and R b each represent hydrogen, the stereo-chemical configuration in which the group Y and the (CH₂)s bridge are on the same side of the plane of the molecule which contains both bridgehead atoms and the ring carbon atom bonded to the group Y will herein be referred to as the exo configuration. Similarly, the configuration of compounds in which the group Y and the bridge (CH₂)s are on opposite sides of the above-mentioned plane of the molecule will herein be referred to as the endo configuration. Preferably compounds of formula (1) have the exo configuration. The compounds of formula (I) can form acid addition salts with acids, such as the conventional pharmaceutically acceptable acids, for example hydrochloric, hydrobromic, phosphoric, acetic, fumaric, salicylic, citric, lactic, mandelic, tartaric, oxalic and methanesulphonic. Preferred combinations of (r, s, t) include (2,2,0), (3,1,0), (2,1,0), (2,1,1) and (3,1,1). Examples of combinations of (r, s, t) include (2,2,0), (3,1,0) and (2,1,0). Halogen in R₁ includes fluoro, chloro, bromo and iodo. The substituent R₁ on Z is preferably γ to the position of the azabicyclic ring. Examples of R₁ include hydrogen, methyl, ethyl, amino, nitro, azido, cyano, chloro, bromo and iodo, preferably hydrogen, methyl and amino. 5-Membered aromatic heterocycles within the definition of variable Z include 1,2-pyrazol-1-yl, 1,2,4-triazol-1-yl, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl, tetrazol-1-yl and tetrazol-2-yl. Preferred heterocycles for Z are 1,2-pyrasol-1-yl, 1,2,4-triazol-1-yl, 1,2,3-triazol-2-yl, tetrazol-1-yl and tetrazol-2-yl, most preferably 1,2,4-triazol-1-yl and tetrazol-2-yl. R a and R b are preferably both hydrogen. The invention also provides a process for the preparation of a compound of formula (I), or a pharmaceutically acceptable salt thereof, which process comprises: (a) cyclising a compound of formula (II): in which (i) A represents Z or a group convertible thereto and B represents -(CH₂) j L₁ where L₁ is a leaving group or A and L₁ together represent -COO-; one of j, k and l is 1 and the other two independently represent an integer of 2 or 3, and R₅ represents hydrogen or an N-protecting group; to give a compound of formula (IIa): in which A′ represents Z or a group convertible thereto, x⁻ is an anion and the remaining variables are as previously defined; or (ii) A represents an electron withdrawing group, B represents hydrogen and R₅ represents -(CH₂) j L₂ where L₂ is a leaving group; one of k and l is 1 and the other and j independently represent an integer of 2 or 3; to give a compound of formula (IIb): in which K represents an electron withdrawing group or A′ and the remaining variables are as previously defined; and thereafter, optionally or as necessary and in any appropriate order, removing any R₅ N-protecting group, converting K to A′, converting A′ to Z, optionally interconverting Z and/or forming a pharmaceutically acceptable salt; or (b) cyclising a compound of formula (III): where R₅ is hydrogen or an N-protecting group, and either C is one, D is another and E is the remainder of -(CH₂) r -, -(CH₂) s - and -(CH₂) t -CR a A′-CHR b - or groups convertible thereto, A′ is Z or a group convertible thereto and L₃ is a leaving group; or C is one and E is the other of -(CH₂) r - and -(CH₂) s - or groups convertible thereto and D represents -(CH₂) t -CR a A′-CHR b - where A′ and L₃ together represent -COO-, and thereafter, optionally or as necessary and in any appropriate order, converting C, D and E to -(CH₂) r -, -(CH₂) s - and (CH₂) t -CHR a A′-CHR b -, removing any R₅ protecting group, converting A′ to Z, optionally interconverting Z and/or forming a pharmaceutically acceptable salt; or (c) cyclising a compound of formula (IV): where F is one and G is the other of -(CH₂) r - and -(CH₂) s - or groups convertible thereto, and one of Y³ and Y⁴ is -(CH₂) u -K and the other is -(CH₂) v W or -(CH₂) v L₄ where K and W are electron withdrawing groups, L₄ is a leaving group, u is 1 or 2 and v is 0 or 1, with the provisos that, when Y⁴ is -(CH₂) v W, v is 1, and Y⁴ is not -(CH₂) v L₄, u and v being such that the desired compound of formula (I) is obtained, and thereafter, optionally or as necessary and in any appropriate order, hydrolysing and decarboxylating the cyclisation product and converting the carbonyl group to CHR a A′ where A′ is Z or a group convertible thereto, converting K to A′ as defined, converting A′ to Z, converting F and G to -(CH₂) r - and -(CH₂) s - as appropriate, interconverting Z and/or forming a pharmaceutically acceptable salt. It will be appreciated that the product of process variant (a) is a compound of formula (I) in which variable Y is hydrogen and that the product of process variant (b) or (c) is a compound of formula (I) in which variable X is hydrogen. In process variant (a), examples of the leaving groups L₁ and L₂ include halo such as chloro or bromo, tosyloxy and mesyloxy. Examples of R₅ when an N-protecting group include benzyl and substituted benzyl. Examples of A and A′ when other than Z include hydroxy, alkoxycarbonyl, benzyloxycarbonyl and cyano. The cyclisation reaction is a nucleophilic substitution which may be carried out under conventional conditions appropriate to the groups A and B. Thus, when B is (CH₂) j Br and A is C₁₋₄ alkoxycarbonyl, the cyclisation is carried out in an inert solvent such as toluene or ether at elevated temperature. When B is (CH₂) j OTos or (CH₂) j O-Mes, it is preferably obtained by treatment of a (CH₂) j OH group with a suitable reagent such as tosylchloride or mesyl chloride, in a base such as pyridine, whereupon the cyclisation may proceed at ambient temperature, or at elevated temperature in an inert solvent such as toluene. This route is suitable where A is hydroxy or Z and R₅ is preferably an N-protecting group and is the preferred route to compounds of formula (I) where X is Z and (r,s,t) is (2,1,0). When A and L₁ together represent -COO-, the cyclisation may be carried out in a lower alkanol such as ethanol in the presence of acid such as hydrogen bromide. In the resulting compound of formula (IIa), A′ will be an alkoxycarbonyl group corresponding to the lower alkanol used for the cyclisation. Where R₅ is an N-protecting group such as benzyl, this may be removed by conventional hydrogenation, preferably catalytically over a suitable catalyst such as Pd/C. Where A′ or K is benzyloxycarbonyl, deesterification and deprotection may be effected simultaneously by conventional hydrogenation. Examples of K and A when an electron withdrawing group include C₁₋₄ alkoxycarbonyl and cyano. When A is an electron withdrawing group such as C₁₋₄ alkoxycarbonyl, B is hydrogen and R₅ is -(CH₂) j L₂ where L₂ is, for example, chloro, the cyclisation may be effected by treatment of the compound of formula (II) with lithium diisopropylamide. In process variant (b), examples of leaving groups L₃ include halo such as chloro and hydroxy. In the group -(CH₂) t -CHR a A′-CHR b -, examples of A′ include hydroxy and cyano. Examples of groups convertible to -(CH₂) t -CR a A′-CHR b - include -(CH₂) t -COCH₂- and -(CH₂) t -CHA′-CH₂-. In process variant (c), examples of L₄ include those given for L₃. Examples of electron withdrawing groups K and W include C₁₋₄ alkoxycarbonyl and cyano. In the group -(CH₂) t -CHA′-CH₂-, examples of A′ include hydroxy, cyano and formyl. In process variant (b), where L₃ is hydroxy and D is -(CH₂) t -CHOH-CH₂-, the cyclisation of compounds of formula (III) may be carried out by pyrolysis, by the method of D.O. Spry and H.S. Aaron, J. Org. Chem., 1969, 34 , 3674, to yield a compound where A′ is hydroxy. Where E is -(CH₂) t -CO-CH₂-, the cyclisation may be carried out under basic conditions where R₅ is benzyl (F.I. Carrol, A.M. Ferguson, and J.B. Lewis, J. Org. Chem. 31 , 2957, 1966). Where L₃ and A′ together represent -COO-, the cyclisation is a rearrangement reaction which can be carried out under acid conditions in a polar solvent, such as hydrogen bromide in ethanol, at ambient temperature, to yield a compound where A′ is a carboxy ester group. It is preferred to protect the nitrogen atom with an R₅ N-protecting group such as benzyl, which may be subsequently removed by hydrogenation over a suitable catalyst such as Pd/C. In process variant (c), where Y³ and Y⁴ both contain carboxy ester groups the cyclisation of compounds of formula (IV) is a Dieckmann reaction which is catalysed by a base such as potassium t-butoxide at elevated temperature in a solvent such as toluene. The resulting β-keto ester is hydrolysed and decarboxylated under conventional conditions such as heating at reflux in dilute hydrochloric acid. In process variant (c) where Y³ and Y⁴ both contain cyano groups the cyclisation is a Thorpe reaction which is catalysed by a base such as potassium t-butoxide at elevated temperature in a solvent such as toluene. The resulting β-keto nitrile is hydrolysed and decarboxylated under conventional conditions such as heating at reflux in dilute hydrochloric acid. Where Y³ is -(CH₂) v L₄, the cyclisation may be carried out as described in EP-0094742 under basic conditions such as sodium hydride and potassium t-butoxide, in an inert polar solvent such as dimethylformamide. Conversions of the carbonyl group from process variants (b) and (c) and of groups A′ and K, and interconversions of Z, may be carried out conventionally, see for example standard text books on heterocyclic chemistry such as 'Comprehensive Heterocyclic Chemistry', A.R. Katritzky and C.W. Rees, Pergamon, 1984. The A′ or K group is first converted, as necessary, to a suitable starting group Z′ for the chosen conversion reaction to give the required group Z. The carbonyl group from process variants (b) and (c) is converted to a group CR a Z′ or C=N-NH₂. An A′ hydroxy group may be oxidised to a carbonyl group by treatment with chromic acid or using dimethyl sulphoxide and dicyclohexylcarbodiimide. A carbonyl group may be converted to a C=N-NH₂ hydrazone group by successive treatment with N,N-dimethylhydrazine and hydrazine. Reduction of the hydrazone with lithium aluminium hydride affords the hydrazine, a CHZ′ group where Z′ is hydrazino. Alternatively, the carbonyl group may be converted to CHZ′ where Z′ is hydrazino by treatment with t-butyl carbazate followed by reduction to the t-butyloxycarbonyl hydrazine by catalytic hydrogenation and removal of the ester function by acid hydrolysis. A carbonyl group may be reacted with hydroxylamine hydrochloride to give an oxime which can then be reduced with either lithium aluminium hydride in tetrahydrofuran at elevated temperature or sodium in isoamyl alcohol, depending on the stereochemistry required, to give a Z′ amino group. Alternatively, the carbonyl group may be reduced to a Z′ hydroxy group with a suitable reducing agent such as sodium borohydride in ethanol at ambient temperature, or sodium in ethanol at elevated temperature, such as the boiling point of the solvent, under an inert atmosphere such as nitrogen, depending on the stereochemistry reguired. Hydrogenation in the presence of Adam's catalyst, PtO₂, provides a stereospecific, endo product. A Z′ hydroxy group may be converted to azido by first converting it to a good leaving group such as mesyloxy or tosyloxy and then displacing it with azide ion. A Z′ azido group may be reduced to a Z′ amino group by reduction with hydrogen catalysed by palladium on carbon. A Z′ alkoxycarbonyl group may be obtained by conventional acid hydrolysis of a Z′ cyano group, followed by esterification. A Z′ bromo group may be obtained from a Z'alkoxycarbonyl group by conversion of the latter to chlorocarbonyl by hydrolysis and treatment with thionyl chloride. The chlorocarbonyl group is reacted with N-hydroxypyridine-2-thione sodium salt, dimethylaminopyridine and triethylamine in bromotrichloromethane. A Z′ alkoxycarbonyl group may be converted to a Z′ amino group by hydrolysis with aqueous acid to a carboxyl group followed by treatment with sodium azide in concentrated sulphuric acid to give an amino group via a Schmidt degradation (ref. Organic Reactions Volume 3 Chapter 8 p307-333, 1946, Publ. John Wiley and Son). A Z′ isocyanide group may be obtained from a Z′ amino group by formylating with a mixture of formic acid and acetic anhydride and then dehydrating the resulting formamide with phosgene in dichloromethane. Alternatively a Z′ isocyanide group may be obtained from a hydrazino group by diazotization to form an azide and then reduction to an amino group and continue as above. A Z′ hydrazino group may be obtained from a Z′amino group by treatment with formaldehyde and potassium cyanide to form a cyanomethylamino group which is then hydrolysed with aqueous hydrochloric acid to afford the amino carboxylic acid. Diazotisation with sodium nitrite in aqueous hydrochloric acid affords the N-nitroso group which can be cyclised to the sydnone with acetic anhydride. The hydrazine can be obtained from this by hydrolysis with aqueous hydrochloric acid (ref. H.U. Daeniker, Helv. Chem. Acta 1967, 50 , 2008). Alternatively, a Z′ hydrazino group may be obtained from a Z′ hydroxy group by treatment with tosyl chloride in pyridine at ambient temperature to afford a tosylate group. This can be converted to a hydrazino group by treatment with anhydrous hydrazine at elevated temperature, for example at reflux for a number of hours. Alternatively, a Z′ hydrazino group may be obtained from a Z′ bromo group by treatment with anhydrous hydrazine, again at reflux for a number of hours. When Z represents a 3-substituted-1,2-pyrazol-1-yl group, a Z′ hydrazino group may be treated with the acetal or bis acetal of R₁COCH₂CHO, where R₁ is hydrogen or an alkyl, alkenyl, alkynyl or cyclopropyl group, under acidic conditions at elevated temperature. A Z 3- or 5-amino-1,2-pyrazol-1-yl group may be obtained by treatment of a Z′ hydrazino group with 2-chloroacrylonitrile under basic conditions at low temperature. When Z represents a 3-substituted-1,2,4-triazol-1-yl group, a Z′ hydrazino group may be treated with the appropriate imidate of the form ROC(=NH)-R₁ where R₁ is hydrogen or an alkyl, alkenyl, alkynyl or cyclopropyl group and R is a lower alkyl group, under basic conditions followed by treatment of the resulting amidrazone with anhydrous formic acid or triethyl orthoformate. Where R₁ is hydrogen the hydrazino group may alternatively be treated with Gold's reagent, (CH₃)₂N-CH=N-CH=N⁺(CH₃)₂Cl⁻. Where the hydrazone is used in place of the hydrazine, the product is a compound of formula (I) in which R a and R b together represent a bond. When Z represents an unsubstituted tetrazol-1-yl group a Z′ isocyano group may be treated with ammonium azide in methanol for a prolonged period of time. A Z tetrazol-2-yl group may be obtained by conversion of a hydrazine via literature procedures ref J.A. Bladin, Chem. Ber. 1885, 1544. A Z 1,2,3-triazol-1-yl group may be obtained by treating a Z′ azide group with acetylene dicarboxylic acid followed by heating which causes decarboxylation. In an alternative strategy, Z is introduced by displacing a Z′ leaving group such as methanesulphonyloxy or bromo with a Z⁻ anion generated by preparing the sodium salt of the azole ZH by treatment with sodium in ethanol. The displacement reaction is carried out at elevated temperature in an inert, polar solvent such as dimethylformamide. The displacement results in a reversal of the stereochemistry at the assymetric carbon. Interconversion of carbon substituents R₁ within a group Z may be carried out conventionally. Thus, for 1,2,4-triazoles, an amino group may be converted to halo such as chloro, azide or -NHNH₂, via a diazonium intermediate. The diazonium intermediate may be obtained by treatment of the amino group with nitrous acid. A halo group may be obtained by displacement of the diazonium ion with cuprous halide at elevated temperature. An azide group may be obtained by displacement of the diazonium ion with sodium azide. A hydrazine may be obtained by reduction of the diazonium ion. A nitro group may be obtained by displacement of the diazonium ion with nitrite ion at elevated temperature. Halo substitutents such as bromine, chlorine or iodine may be introduced into the 5 position of 1,2,4-triazoles and into 2-yl tetrasoles by treatment of the unsubstituted azole with base such as t-butyllithium in pentane followed by reaction with halogen source such as bromine, chlorine in carbon tetrachloride or iodine. A chloro substituent may be converted by reaction with a nucleophile such as methoxide; and alkoxycarbonyl groups may be converted, via carboxy, to an amino substituent. A cyano group may be introduced into 2-yl tetrazoles by conversion of hydrogen to formyl by treatment with t-butyl lithium followed by N-methyl formanilide. The formyl group is converted to an aldoxime by treatment with hydroxylamine hydrochloride. The aldoxime may then be dehydrated with a suitable dehydrating agent such as acetic anhydride to afford the required cyano group. Where applicable, an endo isomer may be obtained by epimerisation of a corresponding exo isomer, the epimerisation reaction being effected by standard procedures at any convenient stage in the process but preferably before the introduction of the group Y. In a further aspect the invention provides a process for the preparation of a compound of formula (I), or a pharmaceutically acceptable salt thereof, which process comprises reacting a compound of formula (IVa): in which R a , R b , r,s and t are as defined in formula (I), one of X′ and Y′ represents hydrogen and the other represents Z′ wherein Z′ is a group convertible to Z as defined in formula (I), to convert Z′ to Z and thereafter optionally forming a pharmaceutically acceptable salt. Intermediates of formula (IVb) and salts thereof: in which R a , R b r,s, and t are as defined in claim 1, one of X″ and Y″ represents hydrogen and the other represents Z″ where Z″ is hydrazino, azido or isocyano or R a and Z″ together are a hydrazone group are novel and form part of the invention. Compounds of formula (II) may be prepared conventionally, for example as described in EP-0287356. Where A is C₁₋₄ alkoxycarbonyl, B is (CH₂) j L₁ and R₅ is hydrogen or an N-protecting group, the compound of formula (II) may be prepared by treating a compound of formula (V): where R₆ is C₁₋₄ alkyl and the remaining variables are as previously defined, with lithium diisopropylamide, prepared in situ from diisopropylamine and n-butyllithium followed by reaction with a compound L₅(CH₂) j L₁ where L₅ is a leaving group, in an inert solvent such as ether at depressed to elevated temperature. Both L₁ and L₅ are suitably bromo. Where A is Z such as optionally substituted 1,2,4-triazol-1-yl, B is CH₂L₁, k and 1 are each 2 and R₅ is an N-protecting group, the compound of formula (II) may be prepared by treating a compound of formula (V) defined above with lithium diisopropylamide prepared as aforesaid followed by reaction with di-t-butylazadicarboxylate at depressed to ambient temperature. The resulting protected 4-hydrazino group is deprotected conventionally by acid hydrolysis and the free hydrazino group converted to an optionally substituted 1,2,4-triazol-1-yl group as described earlier. Other Z groups may be obtained analogously. The R₆OOC- group also in the 4 position is then converted to -CH₂OH by reduction with lithium aluminium hydride and the OH converted to other L₁ as described earlier. Where A and L₁ together represent -COO- and j is 2, the compound of formula (II) may be prepared by reacting the compound of formula (V), treated with lithium diisopropylamide as before, with ethylene oxide in an inert solvent such as ether at depressed to elevated temperature. Alternatively, the compound of formula (II) where A and L₁ together represent -COO, j is 2, k is 2 and l is 1 may be prepared by a 1,3-dipolar cycloaddition reaction which involves reacting a compound of formula (VI): with a compound of formula (VII): where R₇ is an N-protecting group, in the presence of a catalytic amount of trifluoroacetic acid. Where A is an electron withdrawing group such as C₁₋₄ alkoxycarbonyl, B is hydrogen and R₅ is (CH₂) j L₂, the compound of formula (II) may be prepared by reacting the compound of formula (V) where R₅ is hydrogen with a compound L₅(CH₂) j L₂ where L₅ is as previously defined, in a solvent such as acetone in the presence of a base such as potassium carbonate. The leaving group L₅ is preferably bromo and L₂ is preferably chloro. Compounds of formulae (V) are known compounds or may be prepared by analogous methods to those for preparing known compounds. The compound of formula (V) where k is 2, l is 1 and R₅ is benzyl may be prepared by the cyclisation of di-C₁₋₄ alkyl itaconate in the appropriate alkanol with benzylamine at elevated temperature, followed by reduction of the resulting oxo group at the 2-position of the pyrrolidine ring with BH₃ in tetrahydrofuran, at ambient to elevated temperature. Alternatively, and preferably, a dipolar cycloaddition of a C₁₋₄ alkyl acrylate with a compound of formula (VII) in the presence of a catalytic amount of trifluoroacetic acid yields a compound of formula (V) directly. Intermediates of formulae (III) and (IV) are known compounds (e.g. as described in EP-A-0094742 or EP-A-0261763) or may be prepared analogously. Intermediates of formula (III) where A′ and L₃ together represent -COO- are described in, for example, Kuthan et al ., Coll. Czechoslov. Chem. Comm., 1977, 42 , 283 or may be prepared therefrom by conventional hydrogenation of the pyridine ring over 5% Pt/C, and benzylation of the nitrogen atom by treatment with benzyl bromide and potassium carbonate in dry acetone. The compound of formula (III) where A′ and L₃ together represent -COO-, t = O, C is -CH₂- and E is -(CH₂)₂₋ may be prepared by a 1,3-dipolar cycloaddition reaction of a compound of formula (VII) with 5,6-dihydro-2H-pyran-2-one in the presence of a catalytic amount of trifluoroacetic acid. Intermediates of formula (III) where L₃ is a leaving group are described in, for example, Spry et al ., J. Org. Chem., 1969, 34 , 3674 and Hasse et al ., Chem. Ber., 1960, 93 , 1686. Intermediates of formula (IV) are described in or may be prepared from intermediates of formula (V) as described in, for example, Martell et al ., J. Pharm. Sci., 1963, 52(4), 331, Sternbach et al., J.A.C.S., 1952, 74, 2215, Thill et al., J. Org. Chem., 1968, 33, 4376 and EP-0 094 742. Compounds of formulae (VI) and (VII) may be prepared conventionally. Thus, a compound of formula (VI) may be obtained by the reaction of γ-butyrolactone with ethyl formate in the presence of base such as sodium hydride followed by reaction of the resulting formyl derivative (as the enol salt) with formaldehyde. A compound of formula (VII) may be obtained by the reaction of the primary amine R₇NH₂ successively with chloromethyltrimethylsilane and formaldehyde followed by methanol and anhydrous potassium carbonate. Pharmaceutically acceptable salts of the compounds of formula (I) may be formed conventionally by reaction with the appropriate acid such as described above under formula (I). The compounds of the present invention enhance acetylcholine function via an action at muscarinic receptors within the central nervous system and are therefore of potential use in the treatment and/or prophylaxis of dementia. The present invention also provides a pharmaceutical composition, which comprises a compound of formula (I) or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The compositions may be in the form of tablets, capsules, powders, granules, lozenges, suppositories, reconstitutable powders, or liquid preparations such as oral or sterile parenteral solutions or suspensions. In order to obtain consistency of administration it is preferred that a composition of the invention is in the form of a unit dose. Unit dose presentation forms for oral administration may be tablets and capsules and may contain conventional excipients such as binding agents, for example syrup, acacia, gelatin, sorbitol, tragacanth, or polyvinylpyrrolidone; fillers, for example lactose, sugar, maize-starch, calcium phosphate, sorbitol or glycine; tabletting lubricants, for example magnesium stearate; disintegrants, for example starch, polyvinylpyrrolidone, sodium starch glycollate or microcrystalline cellulose; or pharmaceutically acceptable wetting agents such as sodium lauryl sulphate. The solid oral compositions may be prepared by conventional methods of blending, filling, tabletting or the like. Repeated blending operations may be used to distribute the active agent throughout those compositions employing large quantities of fillers. Such operations are of course conventional in the art. The tablets may be coated according to methods well known in normal pharmaceutical practice, in particular with an enteric coating. Oral liquid preparations may be in the form of, for example, emulsions, syrups, or elixirs, or may be presented as a dry product for reconstitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethylcellulose, carboxymethylcellulose, aluminium stearate gel, hydrogenated edible fats; emulsifying agents, for example lecithin, sorbitan monooleate, or acacia; non-aqueous vehicles (which may include edible oils), for example almond oil, fractionated coconut oil, oily esters such as esters of glycerine, propylene glycol, or ethyl alcohol; preservatives, for example methyl or propyl p-hydroxybenzoate or sorbic acid; and if desired conventional flavouring or colouring agents. For parenteral administration, fluid unit dosage forms are prepared utilizing the compound and a sterile vehicle, and, depending on the concentration used, can be either suspended or dissolved in the vehicle. In preparing solutions the compound can be dissolved in water for injection and filter sterilized before filling into a suitable vial or ampoule and sealing. Advantageously adjuvants such as a local anaesthetic, a preservative and buffering agents can be dissolved in the vehicle. To enhance the stability, the composition can be frozen after filling into the vial and the water removed under vacuum. Parenteral suspensions are prepared in substantially the same manner, except that the compound is suspended in the vehicle instead of being dissolved, and sterilization cannot be accomplished by filtration. The compound can be sterilized by exposure to ethylene oxide before suspending in the sterile vehicle. Advantageously, a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the compound. The compositions may contain from 0.1% to 99% by weight, preferably from 10-60% by weight, of the active material, depending on the method of administration. The invention also provides a method of treatment and/or prophylaxis of dementia in mammals including humans, which comprises administering to the sufferer an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. The dose of the compound used in the treatment of such disorders will vary in the usual way with the seriousness of the disorders, the weight of the sufferer, and the relative efficacy of the compound. However, as a general guide suitable unit doses may be 0.05 to 100 mg. for example 0.2 to 50mg; and such unit doses may be administered more than once a day, for example two or three times a day, so that the total daily dosage is in the range of about 0.01 to 5 mg/kg; and such therapy may extend for a number of weeks or months. Within the above indicated dosage ranges no toxicological effects are indicated for the compounds of the invention. In a further aspect the invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof for use as an active therapeutic substance. The invention further provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for use in the treatment and/or prophylaxis of dementia. In another aspect the invention provides the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment and/or prophylaxis of dementia. The following examples illustrate the invention and the following descriptions illustrate the preparation of intermediates thereto. Description 1 3-Quinuclidinyl-hydrazone (D1) 3-Quinuclidinone (10g, 0.08mol) was dissolved in dry EtOH (20ml) and N,N-dimethylhydrazine (16ml, 0.21 mol) was added. The yellow solution was heated at reflux overnight, and then evaporated to dryness under reduced pressure. The yellow syrup (12. 34g, 92%) crystallised on standing to afford N-(3-quinuclidinyl)-N′N′-dimethyl hydrazone. This compound (0.62g, 3.7mmol) was then dissolved in dry EtOH and anhydrous hydrazine (0.8ml, 25mmol) added. The solution was heated at reflux for 4.5h, and then evaporated to dryness under reduced pressure. The resulting white solid was purified by Kugelröhr distillation (b.p. 170 o C, 0.2mmHg) to afford the title compound as a white crystalline solid (0.48g, 93%). m.p. 93-95 o C. ¹H nmr (CDCl₃, 270 MHz) 1.80 (4H, m), 2.40 (1H, pentet), 2.88 (4H, m), 3.48 (2H, s), 4.78 (2H, bs, NH₂). MS: C₇H₁₃N₃: M⁺ 139 Description 2 (±) 3-Quinuclidinyl-hydrazine (D2) 3-Quinuclidinyl-hydrazone (D1) (1.09g, 7.84 mmol) was dissolved in dry THF (20ml) and the solution added dropwise to an iced suspension of LiAlH₄ (600mg, 15.8 mmol) in THF (5ml) under N₂, and the solution allowed to warm to room temperature. This was then heated at reflux under N₂ for 24h. The reaction was quenched with water (0.6ml), 10% NaOH (1.8ml) and water (0.6ml), and the white precipitate filtered off and washed with dry ether. The filtrate was evaporated to dryness under reduced pressure to yield a clear colourless oil (1.0g, 90%), which was used directly in the next stage. ¹H nmr (CDCl₃, 270 MHz) 1.54 (2H, bm), 1.80 (2H, bm), 2.36 (1H, m), 2.53 (1H, m), 2.80 (4H, bm), 3.18 (2H, m). Description 3 1- t Butyloxycarbonyl-2-(3-quinuclidinyl)-hydrazone (D3) 3-Quinuclidinone (1.25g, 10mmol) was dissolved in 60-80 petroleum ether (50ml) and t butyl carbazate (2.0g, 15mmol) was added. The solution was heated at reflux for 24h, allowed to cool overnight, and the resulting crystals filtered to yield the title compound as a white crystalline solid (2.301g, 96%), m.p. 170-172 o C. ¹H nmr (CDCl₃, 250 MHz) 1.51 (9H, s, t Bu), 1.86 (4H, m), 2.83 (5H, complex m), 3.45 (1.65H, s) with 3.55 (0.35H, s). ¹³C nmr (CDCl₃, 67 MHz) 26.5 (CH₂), 28.2 ( t Butyl), 31.0 (CH), 47.3 (CH₂), 52.7 (CH₂), 81.1 ( t Bu-C), 152.9 (C=N), 159.9 (C=O). MS: C₁₂H₂₁N₃O₂ requires 239.1632 observed 239.1634 Analysis: C₁₂H₂₁N₃O₂ % required: C, 60.23; H, 8.85; N, 17.56 % found: C, 59.83; H, 8.77; N, 17.46 Description 4 (±) 1- t Butyloxycarbonyl-2-(3-quinuclidinyl)hydrazine (D4) 1- t Butyloxycarbonyl-2-(3-quinuclidinyl)-hydrazone (D3) (1.0g, 4.18 mmol) was dissolved in ethanol (100ml) and a solution of anhydrous oxalic acid (0.370g, 4.0 mmol) in ethanol (20ml) was added. Palladium on charcoal (10% 0.3g) was added under nitrogen and the solution hydrogenated at atmospheric pressure and 35 o C for 24h. The mixture was filtered through celite under nitrogen, the filtrate evaporated to dryness under reduced pressure, and the residue dissolved in saturated aqueous potassium carbonate. The aqueous solution was extracted with ethyl acetate (2 x 250ml), the organic solutions dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield the title compound (D4) as a clear colourless oil (1.01g, 100%) which crystallised on standing. ¹H nmr (CDCl₃, 270 MHz) 1.47 (9H, s, t Bu), 1.64 (1H, m), 1.86 (2H, m), 2.42 (1H, dm), 2.78 (5H, complex m), 3.66 (3H, m). ¹³C nmr (CDCl₃, 67 MHz) 20.0 (CH₂), 24.1 (CH), 25.4 (CH₂), 28.4 ( t Bu-Me), 47.0 (CH₂), 47.5 (CH₂), 53.4 (CH₂), 56.1 (CH), 80.5 ( t Bu-C), 156.9 (C=O). MS: C₁₂H₂₃N₃O₂ requires 241.1784 observed 241.1792 Description 5 (±) 3-Quinuclidinyl-hydrazine dihydrochloride (D5) 1- t Butyloxycarbonyl-2-(3-quinuclidinyl)-hydrazine (D4) (1.0g, 4.2mmol) was dissolved in 10% HCl/MeOH (40ml) and heated at reflux for 30 min. The solution was evaporated to dryness under reduced pressure, and recrystallised from MeOH and diethyl ether, to afford the title compound as a white crystalline solid (0.78g, 87%), m.p. 245-250 o C, decomp. ¹H nmr (d₆ DMSO, 270 MHz) 1.87 (2H, m), 2.05 (1H, m), 2.28 (1H, m), 2.50 (1H, m), 3.09 (1H, d), 3.31 (4H, bm), 3.62 (2H, m). ¹³C nmr (d₆ DMSO, 67 MHz) 16.5 (CH₂), 21.0 (CH₂), 21.9 (CH), 44.7 (CH₂), 45.5 (CH₂), 49.9 (CH₂), 52.2 (CH). MS: C₇H₁₅N₃ requires 141.1272 observed 141.1265 Description 6 (±) 1- t Butyloxycarbonyl-2-[3-(1-azabicyclo2.2.1]heptanyl]-hydrazone (D6) 3-Oxo-1-azabicyclo[2.2.1]heptane (4.2g, 0.038 mol) was dissolved in petroleum ether (60-80 o ) (250ml) and diethyl ether (10ml). t Butyl carbazate (10g, 0.0758 mol) was added and the solution heated at reflux for 24h, allowed to cool overnight, and then evaporated to dryness under reduced pressure to yield a yellow oil, containing both syn and anti isomers of the product (D6) and excess t butyl carbazate. The oil was used directly in the next step. ¹H NMR (CDCl₃, 270 MHz) 1.68 (1H, m), 1.92 (1H, m), 2.58 (1H, dt), 2.73 (1H, bq), 2.99-3.50 (4H, complex m). ¹³C NMR (CDCl₃, 67 MHz) 27.4 and 28.3 ( t Bu-Me), 38.5, 44.3, 52.9 and 53.3, 57.0, 60.7 and 61.2, 81.3 ( t Bu-quat-C), 152.9 (C=N), 162.9 (C=O). MS: C₁₁H₁₉N₃O₂ requires 225.1487 observed 225.1474 Description 7 (±) exo and endo (1-Azabicyclo[2.2.1]heptan-3-yl) hydrazine dihydrochloride (D7) The mixture of 1- t butyloxycarbonyl-2-[3-(1-azabicyclo[2.2.1]heptanyl)]hydrazone (D6) and unreacted t butylcarbazate was dissolved in ethanol (300ml) and excess anhydrous oxalic acid (4g) added. Palladium on charcoal (10% 0.5g) was added under N₂ and the mixture was hydrogenated at atmospheric pressure and 45 o C for 6h. The solution was then filtered through celite, evaporated to dryness under reduced pressure, dissolved in saturated aqueous K₂CO₃ and extracted with EtOAc (4 x 500ml). The organic extracts were dried (Na₂SO₄), filtered and evaporated to dryness to yield a yellow oil which was purified by column chromatography (basic alumina, eluting with EtOAc/2% MeOH) to yield the saturated t butyloxycarbonyl hydrazine as a mixture of exo and endo isomers [7.10g, 83% based on the starting ketone in Description 6]. This compound (6.77g, 0.030 mol) was dissolved in MeOH/HCl (250ml) and heated at reflux for 20 min. The mixture was evaporated to dryness under reduced pressure and recrystallised from methanol/diethyl ether to yield the title compound as a white crystalline solid (4.34g, 72%), m.p. 245-246 o C (decomp.). ¹H NMR (d₆ DMSO, 270 MHz) 1.46 and 1.79 together (1H, m), 2.01 (1H, complex M), 2.75-3.85 (8H, complex bm). ¹³C NMR (d₆ DMSO, 67 MHz) 19.8 (CH₂), 23.6 (CH₂), 50.9 and 51.7 (CH₂), 55.4 and 55.6 (CH₂), 56.1 and 56.4 (CH), 57.9 and 58.9 (CH). Description 8 (±)3-Methanesulphonyloxy-1-azabicyclo[2.2.2]octane (D8) Quinuclidin-3-ol (10.0g, 0.0787 mol) was dissolved under N₂ in dry dichloromethane (200ml) and cooled in an ice bath to 0 o C. Methanesulphonyl chloride (7.3ml, 10.8g, 0.094 mol, 1.2eq) and dry pyridine (7.64ml, 7.46g, 0.094 mol, 1.2eq) were added and the mixture stirred at 0 o C for 20 min. The solution was then warmed to r.t. and stirred under N₂ for 1h. Saturated aqueous potassium carbonate solution (150ml) was added, and the organic layer extracted and collected. The aqueous layer was re-extracted with EtOAc (3 x 200ml), the organic solutions dried (Na₂SO₄), filtered, and evaporated to dryness under reduced pressure to yield a pale yellow oil which was pumped under high vacuum to remove any last traces of pyridine to yield the title compound (D8) (15.8g, 98%). ¹H NMR (CDCl₃, 270MHz) 1.67 (4H, m), 2.18 (1H, pentet), 2.85 (5H, bm), 3.03 (3H, s, SO₂ Me ), 3.38 (1H, q), 4.82 (1H, m, CHOMs). Description 9 endo-1-Azabicyclo[2.2.1]heptan-3-ol (D9) 1-Azabicyclo[2.2.1]heptan-3-one (6.2g, 0.056 mol) was dissolved in EtOH (50ml). PtO₂ (Adam's catalyst) (1g) was added under nitrogen and the mixture hydrogenated at atmospheric pressure and 45 o C for 6h. The suspension was filtered under nitrogen through celite, the solid washed with EtOH, and the filtrate evaporated to dryness under reduced pressure and pumped dry under high vacuum to yield the title compound (D9) as a beige solid (6.2g, quantitative) ¹H NMR (CDCl₃, 270MHz) 1.43 (1H, m), 2.05 (2H, m), 2.42 (1H, dd), 2.63 (3H, bm), 2.90 (1H, m), 3.05 (1H, m), 4.38 (1H, m, CHOH). Description 10 endo-3-Methanesulphonyloxy-1-azabicyclo[2.2.1]heptane (D10) endo -1-Azabicyclo[2.2.1]heptan-3-ol (D9) (0.58g, 5.13 mmol) was dissolved in dry dichloromethane (25ml), the solution cooled on ice to 0 o C, and methanesulphonyl chloride (0.48ml, 1.2eq) with dry triethylamine (0.86ml, 1.2eq) were added. The mixture was allowed to warm to room temperature and stirred for 2h. The solution was washed with an equal volume of saturated aqeuous potassium carbonate solution, and the aqueous layer was extracted with EtOAc (3 x 100ml). The organic solutions were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield an orange oil. This was purified by column chromatography (basic alumina, eluting with EtOAc/1-3% MeOH) to yield the title compound (D10) as a pale yellow oil (0.70g, 71%). ¹H NMR (CDCl₃, 270MHz) 1.57 (1H, m), 1.92 (1H, m), 2.47 (2H, complex m), 2.67 (2H, m), 2.92 (2H, m), 3.02 (3H, s, SO₂Me), 3.20 (1H, m), 5.08 (1H, m, CHOMs). Description 11 endo-1-Azabicyclo[3.2.1]octan-3-ol (D11) 1-Azabicyclo[3.2.1]octan-3-one (6.0g, 0.048mol) was dissolved in EtOH (100ml) and platinum oxide (Adam's catalyst) (1.0g) added under nitrogen. The suspension was hydrogenated at atmospheric pressure and 40 o C for 7h, and then filtered under nitrogen through celite. The solid was washed with EtOH, and the filtrate was evaporated to dryness under reduced pressure to yield the title compound (D11) as a white solid (6.0g, quantitative). ¹H NMR (CDCl₃, 270MHz) 1.70 (2H, m), 1.93 (1H, dm), 2.14 (2H, m), 2.53 (2H, m), 2.91 (3H, complex m), 3.32 (1H, m), 3.68 (1H, m), 3.79 (1H, bs, OH). Description 12 endo-3-Methanesulphonyloxy-1-azabicyclo[3.2.1]octane (D12) endo -1-Azabicyclo[3.2.1]octan-3-ol (D11) (2.0g, 0.0158mol) was dissolved in dichloromethane (50ml) and the solution cooled on ice to 0 o C. Methanesulphonyl chloride (1.46ml, 1.2eq) and pyridine (1.57ml, 1.2eq) were added with stirring, the mixture allowed to warm to room temperature and stirred for 1.5h. The organic solution was then washed with an equal volume of aqueous saturated potassium carbonate solution and the aqueous layer extracted with EtOAc (3 x 100ml). The organic extracts were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield a yellow oil. This was purified by column chromatography, using basic alumina and eluting with EtOAc/MeOH 1-5%, to yield the title compound (D12) as a colourless oil (1.20g, 37%). ¹H NMR (CDCl₃, 270MHz) 1.74 (1H, m), 2.08 (3H, m), 2.21 (1H, m), 2.58 (1H, d), 2.70 (1H, dt), 2.87 (1H, m), 2.94 (3H, s, SO₂Me), 3.21 (3H, m), 4.63 (1H, m). Description 13 5-Methyltetrazole (D13) Acetonitrile (4.1g, 5.22ml, 0.10mol), sodium azide (7.48g, 0.115mol), acetic acid (6.59ml, 0.115mol) and isopropanol (20ml) were mixed and heated in a PTFE-lined autoclave at 130 o C for 5 days, with stirring. The reaction was allowed to cool, transferred to a round-bottomed flask with EtOH, and evaporated to dryness under reduced pressure. The solid was extracted repeatedly with boiling n-butyl acetate, until no further solid dissolved. The organic extracts were evaporated to a small volume under reduced pressure and the solid allowed to crystallise out, to give the title compound (D13) as a pale cream solid (3.25g, 39%). ¹H NMR (CDCl₃, 270MHz) 1.85 (3H, s, Me), 4.12 (1H, bs, NH) M.S. found 84.0436 C₂H₄N₄ requires 84.0436. Description 14 5-Ethyltetrazole (D14) As for Description 13 using propionitrile (7.13ml, 0.10mol) instead of acetonitrile, at 140 o C for 5 days, giving the product (D14) as a pale cream solid (800mg, 8%) ¹H NMR (d₆ DMSO, 270MHz) 1.27 (3H, t, CH₃), 2.67 (2H, q, CH₂), 4.62 (1H, bs, NH) General method for the synthesis of azole sodium salt (D15-21) Sodium metal (0.01mol) was dissolved in EtOH (50ml) under nitrogen at 5 o C, the solution warmed to room temperature and the azole (0.01 mol) added. The suspension was stirred until dissolution occurred, and the solution was then evaporated to dryness under reduced pressure and the white solid dried in a vacuum oven, at 50 o C under high vacuum. The salt was then used directly in the next stage. Salts made thus: (D15) 5-Aminotetrazole (D16) 1N-Tetrazole (D17) 5-Methyltetrazole (from D13) (D18) 5-Ethyltetrazole (from D14) (D19) 1,2,4-triazole (D20) 3-Amino-1,2,4-triazole (D21) 4-Methyl-1,2,3-triazole Description 22 exo-3-Methanesulphonyloxy-1-azabicyclo[2.2.1]heptane (D22) exo -1-Azabicyclo[2.2.1]heptan-3-ol (400mg, 3.54mmol) was dissolved in dry dichloromethane (50ml), the solution cooled on ice to 0 o C, and methanesulphonyl chloride (0.27ml, 1.2 equiv) with dry triethylamine (0.592ml, 1.2 equiv) were added. The mixture was allowed to warm to room temperature and stirred for 2h. The organic solution was washed with an equal volume of saturated aqueous potassium carbonate solution, and the aqueous layer extracted with EtOAc (2 x 100ml). The organic solutions were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield a yellow oil which was purified by column chromatography (basic alumina, 1-2% MeOH/EtOAc) to afford the title compound as a clear oil (540mg, 80%). ¹H NMR (CDCl₃) 1.11 (1H, m), 1.73 (1H, m), 2.43 (3H, m), 2.77 (2H, dm), 2.87 (1H, d), 2.94 (1H, dm), 3.03 (3H, s, SO₂ M e), 4.53 (1H, m, CH-OMs) Description 23 (±) 5-Bromo-1-azabicyclo[3.2.1]octane (D23) (±) Ethyl-1-azabicyclo[3.2.1]oct-5-ylcarboxylate (EP 0287356, Example 7, 18.97g, 0.104 mole) in hydrochloric acid (8N, 200ml) was heated under reflux for 3h. The solution was then concentrated in vacuo to a hygroscopic solid which was dissolved in thionyl chloride (150ml) and heated under reflux for 0.5h. The mixture was then concentrated in vacuo to give the acid chloride hydrochloride salt as a solid, which was freed from excess thionyl chloride by co-evaporation with toluene. This solid was added in portions to a mixture of the sodium salt of 1-hydroxypyridine-2-thione (17.35g, 0.116 mole), triethylamine (29ml, 0.208 mole) and 4-dimethylaminopyridine (0.5g, 0.004 mole) in dry acetonitrile (300ml) at -20 o C. The mixture was allowed to warm slowly to room temperature then refluxed for 2h and evaporated in vacuo . Bromotrichloromethane (250ml) was then added to the residue and the resulting solution was refluxed for 3h. After cooling the reaction mixture was poured into saturated aqueous potassium carbonate solution (150ml) and the mixture was extracted with chloroform (4 x 200ml). The combined organic extracts were dried (Na₂SO₄) and evaporated to give an oil which was subjected to column chromatography on silica using 3-7% methanol/chloroform as eluant to give the crude product which was distilled in vacuo to afford the title compound (D23) as a colourless oil (9.18g, 47%) b.p. 140 o C at 1.5mmHg. ¹H NMR (CDCl₃) δ: 1.57 (1H, m), 1.88 (1H, m), 2.16-2.37 (4H, m), 2.71-2.92 (3H, m), 3.07 (2H, s), 3.18 (1H, m). ¹³C NMR (CDCl₃) δ: 23.83, 40.73, 42.99, 52.01, 53.86, 62.45, 68.43 Description 24 (±) 1-Azabicyclo[3.2.1]oct-5-ylhydrazine (D24) (±) 5-Bromo-1-azabicyclo[3.2.1]octane (D23, 1g, 5.3mmol) in anhydrous hydrazine (10ml) was heated at reflux for 0.5h. The mixture was then cooled and evaporated in vacuo . The residue was taken up in methanol and an aqueous solution of sodium hydroxide (2.63ml of a 2M solution, 5.3 mmol) was added. The resulting solution was evaporated to dryness then taken up in dry methanol (30ml) and evaporated to dryness once more. This procedure was repeated once more to remove the last traces of water to give a gum (1.34g) which was essentially the title compound (D24) and sodium bromide and was used without further purification. ¹³C NMR (d₆DMSO) δ: 17.56, 29.30, 32.47, 49.64, 51.97, 58.41, 63.59 Description 25 (±) 3-Azido-1-azabicyclo[2.2.2]octane oxalate salt (D25) 3-Methanesulphonyloxy-1-azabicyclo[2.2.2]octane (D8) (16g) in dry dimethyl formamide (100ml) was treated with sodium azide (10.4g) (0.16 mole, 2eq) at reflux for 5h. The reaction was then cooled and concentrated in vacuo . The residue was then partitioned between saturated aqueous potassium carbonate solution and ether. The organic phase was separated and concentrated to a gum. This was chromatographed on alumina in a gradient of 5-10% methanol in ethyl acetate. The main fraction which eluted first was concentrated to a gum which was Kugelröhr distilled to afford a colourless oil (B.P. 90-100 o C at 0.1mm). The oxalate salt of this oil crystallised from acetone/ether to give the title compound (D25) (4.2g, 0.0173 mole 22%) m.p. 100-102 o C. ¹H NMR (CDCl₃, 250MHz) δ: 1.8-2.23 (4H, m), 2.28-2.38 (1H, m), 3.05-3.15 (1H, m), 3.15-3.38 (4H, m), 3.55-3.70 (1H, m), 4.20-4.30 (1H, m). Description 26 Ethyl 1-benzyl-4-(N,N′-di-tert-butyloxycarbonylhydrazino)piperidin-4-ylcarboxylate (D26) A solution of diisopropylamine (8.8ml, 0.063mol) in ether (400ml) at -70 o C under nitrogen was treated with 1.6M n-butyllithium in hexane (37.5ml, 0.060mol) and stirred for 10 minutes. A solution of ethyl 1-benzylpiperidin-4-ylcarboxylate (13.6g, 0.055mol) in ether (70ml) was added over 5 minutes and the resulting mixture then stirred at -70 o C for 40 minutes, before adding a solution of di-tert-butylazodicarboxylate (13.5g, 0.058mol) in ether (80ml). The reaction mixture was allowed to warm to room temperature over 0.5h, then stirred for a further 2h before adding dilute potassium carbonate solution (150ml). The ether layer was separated, dried (Na₂SO₄) and concentrated in vacuo to leave an orange oil. This was chromatographed on silica gel eluting initially with 20% ether/60-80 petrol, then with neat ether to afford the title compound (D26) (14.2g, 54%) as a yellow oil. ¹H NMR (CDCl₃, 250MHz) δ: 1.24 (3H, t, J=7Hz), 1.38-1.62 (18H, m), 1.85-1.97 (1H, m), 2.02-2.15 (1H, m), 2.34-2.55 (4H, m), 2.61-2.75 (2H, m), 3.50 (2H, s), 4.07-4.25 (2H, m), 6.02 and 6.30 (together 1H, each br.s), 7.20-7.35 (5H, m). Description 27 Ethyl 1-benzyl-4-hydrazinopiperidin-4-yl-carboxylate dihydrochloride salt (D27) A solution of ethyl 1-benzyl-4-(N,N′-di-tert-butyloxycarbonylhydrazino)piperidin-4-yl-carboxylate (D26, 14.2g, 0.030 mol) in methanol (50ml) was treated with 10% HCl/methanol (100ml) and heated under reflux for 2h. The solution was concentrated in vacuo and the residue treated with dry toluene (80ml) and again concentrated in vacuo to remove any traces of moisture. The residue was trituated with ether and the material filtered off and immediately placed in a vacuum dessicator to give the title compound (D27) (9.48g, 90%) as a very hygroscopic orange solid. ¹H NMR (CD₃OD, 250MHz) δ: 1.31 (3H, t, J=7Hz), 2.05-2.20 (2H, m), 2.38-2.58 (2H, m), 3.25-3.60 (4H, m), 4.29 (2H, q, J=7Hz), 4.35-4.45 (2H, m), 7.43-7.66 (5H, m). Description 28 Ethyl 1-benzyl-4-(1,2,4-triazol-1-yl)-piperidin-4-yl carboxylate (D28) A stirred suspension of ethyl 1-benzyl-4-hydrazinopiperdin-4-ylcarboxylate dihydrochloride salt (D27, 2.0g, 0.0057 mol) in absolute chloroform (200ml) was treated with Gold's reagent ([3-(dimethylamino)-2-azaprop-2-en-1-ylidene]-dimethylammonium chloride) (930mg, 0.0057 mol) and triethylamine (1.6ml, 0.0114 mol) and the mixture heated at reflux under nitrogen for 2.5h. The solution was allowed to cool, treated with concentrated potassium carbonate solution and the organic layer separated, dried (Na₂SO₄) and concentrated in vacuo to leave an orange oil. This was chromatographed on silica gel eluting first with ethyl acetate to obtain the title compound (D28), then with methanol to obtain a high polar intermediate, which on heating under reflux in toluene for 20 minutes gave a further batch of the triazole product. These two batches were combined to give the title compound (D28) (770mg, 43%) as an orange oil. ¹H NMR (CDCl₃, 250MHz) δ: 1.20 (3H, t, J=7Hz), 2.20-2.75 (8H, m), 3.46 (2H, s), 4.17 (2H, q, J=7Hz), 7.22-7.38 (5H, m), 7.99 (1H, s), 8.26 (1H, s). Description 29 1-Benzyl-4-hydroxymethyl-4-(1,2,4-triazol-1-yl) piperidine (D29) A solution of ethyl 1-benzyl-4-(1,2,4-triazol-1-yl)piperidin-4-ylcarboxylate (D28, 460mg, 0.00147mol) in ether (15ml) was added dropwise to a stirred suspension of lithium aluminium hydride (67mg, 0.00175 mol) in ether (25ml) and dry THF (8ml) at 0 o C under nitrogen. The reaction mixture was allowed to warm to 15 o C over 20 minutes, then treated with water (0.06ml), followed by 10% sodium hydroxide solution (0.18ml) and then water (0.06ml). The grey precipitate was removed by filtration through a pad of Kieselguhr and the filtrate dried (Na₂SO₄) and concentrated in vacuo to leave a yellow oil. This was purified by passage through a short silica gel column eluting with 10% methanol/ethyl acetate to give the title compound (D29) (320mg, 80%) as a pale yellow oil. ¹H NMR (CDCl₃, 250 MHz) δ: 1.97-2.28 (4H, m), 2.33-2.50 (2H, m), 2.60-2.75 (2H, m), 3.44 (2H, s), 3.70 (2H, s), 4.45 (1H, br.s, OH), 7.22-7.40 (5H, m), 7.77 (1H, s), 8.10 (1H, s). Description 30 Ethyl 1-benzyl-4-(3-methyl-1,2,4-triazol-1-yl)piperidin-4-ylcarboxylate (D30) A solution of ethyl 1-benzyl-4-hydrazino-piperidin-4-ylcarboxylate dihydrochloride salt (D27, 3.0g, 0.0086 mol) in methanol (100ml) under nitrogen was treated with methyl acetimidate hydrochloride (940mg, 0.0086 mol) and triethylamine (3.7ml; 0.026 mol) and stirred at room temperature for 3h. The solution was concentrated in vacuo at below 30 o C and the residue treated with triethylorthoformate (50ml) and pyridine (5ml) and the heterogenous mixture stirred for 18h at room temperature, followed by heating under reflux for 1.5h. The mixture was concentrated in vacuo and the residue treated with potassium carbonate solution (30ml) and extracted with ethyl acetate (2 x 40ml). The combined extracts were dried (Na₂SO₄) and concentrated in vacuo to leave a dark red oil, which was chromatographed on silica gel eluting initially with ether, then with 1:1 ethyl acetate/ether to afford the title compound (D30) as a yellow oil (430mg, 15%). ¹H NMR (CDCl₃, 250MHz) δ: 1.18 (3H, t, J=7Hz), 2.25-2.70 (8H, m), 2.40 (3H, s), 3.45 (2H, s), 4.15 (2H, q, J=7Hz), 7.20-7.40 (5H, m), 8.12 (1H, s). Description 31 1-Benzyl-4-hydroxymethyl-4-(3-methyl-1,2,4-triazol-1-yl)piperidine (D31) The title compound (D31) was prepared from ethyl 1-benzyl-4-(3-methyl-1,2,4-triazol-1-yl)piperidin-4-ylcarboxylate (D30) using the method given in Description 29 as a yellow oil (100%). It was used without purification. ¹H NMR (CDCl₃, 250MHz) δ: 1.96-2.12 (2H, m), 2.15-2.43 (4H, m), 2.31 (3H, s), 2.58-2.70 (2H, m), 3.47 (2H, s), 3.70 (2H, s), 4.17 1H, br.s), 7.20-7.40 (5H, m), 7.97 (1H, s). Example 1 (±) 3-(3-Methylpyrazol-1-yl)-1-azabicyclo[2.2.2]octane oxalate salt (E1) 3-Quinuclidinyl-hydrazine (D2) (1.0g, 7.1mmol) was dissolved in EtOH (4ml) and glacial acetic acid (4ml) added followed by acetylacetaldehyde dimethyl acetal (4ml). The mixture was heated with stirring at reflux for 2h and evaporated to dryness under reduced pressure. Saturated aqueous potassium carbonate (40ml) was added and the solution extracted with diethyl ether (3 x 250ml). The organic extracts were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield a brown oil, which was purified by column chromatography (basic alumina, eluting with 10% Et₂O/EtOAc) to afford a yellow oil (400mg, 27%). This was crystallised as the oxalate salt and recrystallised from methanol/ether, m.p. 106-109 o C. ¹H nmr oxalate salt (d₆ DMSO, 270 MHz) 1.72 (2H, m), 1.95 (2H, m), 2.21 (3H, s, pyrazole-Me), 2.30 (1H, m), 3.26 (3H, m), 3.42 (1H, m), 3.82 (2H, bm), 4.78 (1H, m), 6.13 (1H, d, pyrazole-CH), 7.79 (1H, d, pyrazole-CH) ¹³C nmr (d₆ DMSO, 67 MHz) 13.5, 17.5, 21.4, 26.8, 45.2, 45.7, 49.1, 54.3, 105.4 (pyrazole-CH), 130.6 (pyrazole-CH), 147.2 (oxalate), 163.5 (pyrazole-quat C). MS: C₁₁H₁₇N₃: M⁺ 191 Analysis: C₁₁H₁₇N₃. 1.5 C₂H₂O₄ % required C, 51.53; H, 6.13; N, 12.88 % found: C, 51.41; H, 6.10; N, 12.74 Example 2 (±) 3-(Pyrazol-1-yl)-1-azabicyclo[2.2.2]octane dihydrochloride salt (E2) 3-Quinuclidinyl-hydrazine (D2) (1.0g, 7.1mmol) was dissolved in EtOH (4ml) and glacial acetic acid (4ml) added, followed by malonaldehyde bis(dimethylacetal) (4ml). The solution was heated at reflux for 2h and then evaporated to dryness under reduced pressure. The residue was dissolved in saturated aqueous K₂CO₃ and extracted with diethyl ether (3 x 250ml). The organic extracts were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield a brown oil which was purified by column chromatography (basic alumina eluting with ether to EtOAc). The resulting oil was crystallised as the dihydrochloride salt from ether and recrystallised from methanol/ether to yield a white crystalline solid (84mg), m.p. 192-194 o C (hygroscopic). ¹H nmr (d₆ DMSO, 270 MHz) 1.85 (2H, bm), 2.04 (3H, bm), 2.25 (1H, m), 2.41 (1H, m), 3.40 (2H, bm), 3.94 (2H, m), 5.02 (1H, m), 6.47 (1H, t, pyrazole-CH), 7.6 (1H, d, pyrazole-CH), 8.08 (1H, d, pyrazole-CH). ¹³C nmr (d₆ DMSO, 67 MHz) 17.4 (CH₂), 20.2 (CH₂), 21.3 (CH₂), 27.0 (CH), 45.5 (CH₂), 48.9 (CH₂), 54.6 (CH), 106.0 (CH, pyrazole), 130.1 (CH, pyrazole), 138.8 (CH, pyrazole). MS: C₁₀H₁₅N₃. M⁺: 177 Analysis: C₁₀H₁₅N₃. HCl.H₂O.MeOH % required: C, 48.73; H, 6.77; N, 14.21 % found: C, 48.43; H, 6.86; N, 14.44 Examples 3 and 4 (±) 3-(3-Aminopyrazol-1-yl)-1-azabicyclo[2.2.2]octane (E3) and (±) 3-(5-aminopyrazol-1-yl)-1-azabicyclo[2.2.2]octane (E4) 3-Quinuclidinyl-hydrazine (D2) (5.0g, 35.5mmol) was added to a solution of K₂CO₃ (4.90g, 35.5mmol) in water (13ml) and the ice-cooled solution was stirred vigorously while 2-chloroacrylonitrile (3.10g, 2.83ml, 35.5mmol) was added dropwise over 1 minute. The solution was then stirred at room temperature overnight. The mixture was diluted with MeOH, evaporated to a slurry under reduced pressure, suspended in saturated aqueous potassium carbonate and extracted with EtOAc (3 x 100ml), followed by CHCl₃ (4 x 250ml). The organic extracts were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield a brown oil, which was purified by column chromatography (neutral alumina eluting with chloroform), to yield a faster running fraction (E3) (44mg) and a slower running fraction (E4) (32mg). Both were crystallised separately by trituration with diethyl ether, to yield white crystalline solids. (E3) m.p. 141-145 o C ¹H nmr (d₆ DMSO, 270 MHz) 1.25 (1H, m), 1.72 (3H, m), 1.97 (1H, m), 2.82 (3H, m), 3.15 (2H, m), 3.72 (1H, dd), 4.26 (1H, m), 5.42 (1H, d, pyrazole-CH), 7.15 (1H, d, pyrazole-CH). ¹³C nmr (d₆ DMSO, 67 MHz) 19.54 (CH₂), 25.45 (CH₂), 26.34 (CH), 46.55 (CH₂), 46.83 (CH₂), 50.68 (CH₂), 52.06 (CH), 89.40 (CH, pyrazole), 136.60 (CH, pyrazole), 145.55 (quat C, pyrazole). MS: C₁₀H₁₆N₄ requires 192.1365 observed 192.1377 (E4) m.p. 112-115 o C ¹H nmr (d₆ DMSO, 270 MHz) 1.26 (1H, m), 1.60 (3H, m), 1.98 (1H, m), 2.68 (3H, m), 2.88 (1H, m), 3.19 (2H, m), 4.08 (1H, m), 5.42 (1H, d, pyrazole-CH), 7.43 (1H, d, pyrazole-CH). ¹³C nmr (d₆ DMSO, 67 MHz) 20.18 (CH₂), 25.75 (CH₂), 27.65 (CH), 46.48 (CH₂), 46.85 (CH₂), 51.81 (CH₂), 57.06 (CH), 91.67 (CH, pyrazole), 129.10 (CH, pyrazole), 154.84 (quat C, pyrazole). Analysis: C₁₀H₁₆N₄.1/3 H₂O % required: C, 60.61; H, 8.42; N, 28.28 % found: C, 60.90; H, 8.12; N, 28.48 MS: C₁₀H₁₆N₄ required 192.1374 observed 192.1375 Example 5 3-(3-Methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]oct-2-ene dihydrochloride (E5) 3-Quinuclidinyl-hydrazone (D1) (0.20g, 1.44mmol) was dissolved in dry MeOH (10ml) and methyl acetimidate hydrochloride (0.158g, 1.45mmol) added, followed by triethylamine (0.2ml, 1 eq). The clear solution was stirred for 3h under N₂, evaporated to dryness under reduced pressure, and anhydrous pyridine (2ml) and anhydrous triethylorthoformate (20ml) added. The suspension was stirred under N₂ overnight at room temperature and then heated at reflux for 1h. The resulting yellow suspension was evaporated to dryness under reduced pressure, dissolved in saturated, aqueous potassium carbonate and extracted with EtOAc (3 x 70ml). The organic extracts were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure. The resulting orange semi-solid was purified by Kugelröhr distillation (b.p. 180 o C at 0.08mmHg) to yield a clear colourless oil (171mg, 63%) which was purified as the dihydrochloride salt, m.p. 212-214 o C (decomp.). ¹H nmr (d₆ DMSO, 270 MHz) 2.00 (2H, bm), 2.18 (2H, bm), 2.49 (3H, triazole-Me), 3.20 (2H, m), 3.71 (2H, m), 4.02 (1H, m), 7.19 (1H, s, olefinic-CH), 9.28 (1H, s, triazole-CH). ¹³C nmr (d₆ DMSO, 67 MHz) 13.7 (CH₃-triazole), 23.0 (CH₂), 26.8 (CH), 50.0 (CH₂), 114.5 (olefinic CH), 142.0 (quat-C), 144.8 (triazole-CH) 161.8 (quat-C). MS: C₁₀H₁₄N₄ M⁺: 190 Analysis: C₁₀H₁₄N₄.2HCl % requires: C, 45.62; H, 6.08; N, 21.29 % found: C, 45.41; 6.12; N, 21.27 Example 6 (±) 3-(3-Methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2] octane dihydrochloride salt (E6) 3-Quinuclidinyl-hydrazine dihydrochloride (D5) (0.78g, 3.6mmol) was suspended in dry methanol (30ml) and methyl acetimidate hydrochloride (0.40g, 3.65mmol) added, followed by triethylamine (1.52ml, 3eq). The solution was stirred for 3h at room temperature under N₂, and then evaporated to dryness under reduced pressure at a temperature not exceeding 30 o C. Anhydrous triethylorthoformate (40ml) and anhydrous pyridine (4ml) were added, and the suspension was stirred overnight at room temperature under N₂ and then refluxed under N₂ for 1.5h. The mixture was cooled, evaporated to dryness under reduced pressure and the residue was dissolved in saturated aqueous potassium carbonate solution (40ml). The solution was extracted with ethyl acetate (2 x 300ml), the organic extracts dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure. The resulting oil was purified by column chromatography using neutral alumina and with gradient elution using ethyl acetate to 2% methanol in ethyl acetate. The resulting clear oil was crystallised as the dihydrochloride salt using diethyl ether/methanol solution and recrystallised in acetone/ether to afford the title compound as white crystals (110mg, 13%), m.p. >250 o C. ¹H nmr (d₆ DMSO, 270 MHz) 1.85 (2H, bm), 2.04 (2H, bm), 2.42 (3H, s, Me), 2.50 (1H, m), 3.40 (4H, bm), 3.80 (2H, bm), 5.07 (1H, m), 9.05 (1H, s, triazole CH). ¹³C nmr (d₆ DMSO, 67 MHz) 13.1 (CH₃), 17.2 (CH₂), 21.3 (CH₂), 21.3 (CH₂), 26.0 (CH), 45.0 (CH₂), 45.5 (CH₂), 48.9 (CH₂), 53.4 (CH), 143.9 (triazole-CH), 157.0 (triazole quat C). MS: C₁₀H₁₆N₄ requires 192.1374 observed 192.1375 Analysis: C₁₀H₁₈N₄.Cl₂ % required: C, 45.29; H, 6.84; N, 21.13 % found: C, 44.99; H, 6.93; N, 20.82 Example 7 (±) 3-(1,2,4-Triazol-1-yl)-1-azabicyclo[2.2.2]octane dihydrochloride salt (E7) 3-Quinuclidyl-hydrazine dihydrochloride salt (D5) (200mg, 1.0mmol) and Gold's reagent ([3-(dimethylamino)-2-azaprop-2-en-1-ylidene]-dimethylammonium chloride) (153mg, 1.0mmol) were dissolved in dry CHCl₃ (20ml) under N₂ and dry Et₃N (0.28ml, 2.0mmol) was added. The solution was heated at reflux under nitrogen for 2.5h. The solution was cooled, saturated aqueous potassium carbonate was added and the organic layer separated. The aqueous layer was extracted with CHCl₃ (2 x 100ml), the organic extracts were dried (Na₂SO₄), filtered and were evaporated to dryness under reduced pressure. The resulting orange/yellow oil was purified by column chromatography (basic alumina eluting with 2% MeOH/EtOAc). The resulting clear oil was recrystallised as the dihydrochloride salt from methanol/acetone/diethyl ether (45mg, 0.18mmol, 18%), m.p. 187-190 o C. ¹H NMR (d₆ DMSO, 270 MHz) 1.83 (2H, m), 1.99 (2H, m), 2.42 (1H, m), 3.29 (4H, bm), 3.86 (2H, bm), 5.08 (1H, m), 8.28 (1H, s, triazole-CH), 9.02 (1H, s, triazole-CH). ¹³C NMR (d₆ DMSO, 67·MHz) 17.1 (CH₂), 21.2 (CH₂), 26.5 (CH), 44.8 (CH₂), 45.2 (CH₂), 49.0 (CH₂), 53.3 (CH), 144.0 (triazole-CH), 150.2 (triazole-CH) MS: C₉H₁₄N₄ requires 178.1206 M⁺ observed 178.1221 Analysis: C₉H₁₄N₄.2HCl % requires C, 43.0; H, 6.4; N, 22.3 found C, 42.97; H, 6.48; N, 22.23 Example 8 (±) exo-3-(3-Methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane dihydrochloride salt (E8) (±) exo and endo (1-Azabicyclo[2.2.1] heptan-3-yl)-hydrazine dihydrochloride (D7) (0.5g, 2.5mmol) was dissolved in dry methanol (30ml) and methyl acetimidate hydrochloride (0.274g, 2.5mmol) was added, followed by dry triethylamine (1.05ml, 3eq). The solution was stirred for 3h at 25 o C under N₂, and then evaporated to dryness under reduced pressure at a temperature not exceeding 30 o C. Anhydrous triethylorthoformate (20ml) and anhydrous pyridine (2ml) were added, and the suspension was stirred overnight at room temperature and then heated at reflux under N₂ for 1.5h. The mixture was cooled, evaporated to dryness under reduced pressure, and the residue dissolved in saturated aqueous K₂CO₃. The aqueous solution was extracted with ethyl acetate (3 x 250ml) and the organic extracts were dried, filtered and evaporated to dryness under reduced pressure to yield a yellow oil which was purified by column chromatography (basic alumina, eluting with EtOAc/MeOH 3-6%). The compound thus isolated was crystallised from ether as the dihydrochloride salt and was recrystallised from methanol/diethyl ether to afford the title compound (E8) as a white crystalline solid (30mg, 0.12mmol, 5%) m.p. 236-240 o C (decomp). ¹H NMR (d₆ DMSO, 270 MHz) 1.75 (1H, m), 2.08 (1H, m), 2.31 (3H, s, triazole-CH₃), 3.14 (1H, d), 3.28 (3H, complex m), 3.63 (2H, m), 3.82 (1H, m), 4.92 (1H, m), 8.90 (1H, s, triazole-CH) ¹³C (d₆ DMSO, 67 MHz) 13.1 (CH₃-triazole), 24.3 (CH₂), 41.7 (CH), 51.0 (CH₂), 56.8 (CH₂), 57.3 (CH₂), 58.4 (CH), 143.9 (CH, triazole-CH), 158.7 (quat-C) Example 9 (±) exo-3-(1,2,4-Triazol-1-yl)-1-azabicyclo[2.2.1] heptane dihydrochloride salt (E9) (±) exo and endo (1-Azabicyclo[2.2.1]heptan-3-yl)hydrazine dihydrochloride (D7) (500mg, 2.5mmol) and Gold's reagent ([3-(dimethylamino)-2-azaprop-2-en-1-ylidine]dimethylammonium chloride) (409mg, 2.5mmol) were dissolved in dry CHCl₃ (40ml) under N₂ and dry triethylamine (0.70ml, 2eq) added. The solution was heated at reflux under N₂ for 2.5h. The solution was cooled, saturated aqueous potassium carbonate was added and the organic layer separated. The aqueous layer was extracted with CHCl₃ (2 x 100ml) and the organic solutions were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield a yellow oil (0.5g). This was purified by column chromatography (basic alumina, eluting with EtOAc/MeOH 2%) to yield a clear colourless oil which was crystallised as the dihydrochloride salt and recrystallised from methanol/ diethyl ether to afford the title compound (E9) as pale yellow crystals, m.p. 215-219 o C (decomp). ¹H NMR (d₆ DMSO, 270 MHz) 1.86 (1H, m), 2.16 (1H, m), 3.20-4.03 (7H, complex m), 5.12 (1H, m), 8.42 (1H, bs, triazole-CH), 9.21 (1H, bs, triazole-CH). ¹³C NMR (d₆ DMSO, 67 MHz) 24.3 (CH₂), 41.8 (CH), 50.9 (CH₂), 56.7 (CH₂), 57.3 (CH₂), 58.6 (CH), 150.0 (2C-triazole-2CH) Example 10 (±) 3-(5-Methyltetrazol-2-yl)-1-asabicyclo[2.2.2]octane hydrochloride salt (E10) 3-Methanesulphonyloxy-1-azabicyclo[2.2.2]octane (D8) (1.0g, 4.9mmol) was dissolved in dry DMF (50ml) and the sodium salt of 5-methyltetrazole (D17) (1.26g, 2.5eq) was added, and the solution was refluxed for 1h under nitrogen. The solution was evaporated to dryness under reduced pressure, and the resulting syrup dissolved in aqueous saturated potassium carbonate solution (50ml). The aqueous solution was extracted with EtOAc (3 x 100ml), the organic extracts dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield an oil. This was purified by column chromatography using basic alumina and eluting with EtOAc/MeOH 1-5%, to yield the free base of the title compound (E10) (90mg, 10%), which was crystallised using 1.0M HCl in ether solution as the hydrochloride salt, m.p. 196-198 o C. ¹H NMR (d₆ DMSO, 270MHz) 1.63 (1H, m), 1.79 (1H, m), 2.05 (2H, m), 2.50 (3H, s, azole-CH₃), 3.32 (5H, m), 3.92 (2H, m), 5.44 (1H, m, CH-azole) ¹³C NMR 10.6 (CH₃), 17.1 (CH₂), 20.9 CH₂), 25.6 (CH), 45.1 (CH₂), 45.5 (CH₂), 49.0 (CH₂), 57.1 (CH), 162.4 (azole quat-C) MS: found 199.1328 C₉H₁₅N₅ requires 199.1328 Analysis C₉H₁₅N₅.HCl ¼H₂O found C: 46.53; H: 6.96; N: 29.45% requires C: 46.15; H: 7.05; N: 29.91% Example 11 (±) 3-(5-Aminotetrazol-2-yl)-1-azabicyclo[2.2.2]octane (E11) 3-Methanesulphonyloxy-1-azabicylo[2.2.2]octane (D8) (2.0g, 9.7mmol) and the sodium salt of 5-aminotetrazole (D15) (2.5g, 2.0eq) were dissolved in dry DMF (50ml) and the reaction carried out as for Example 10. The product (E11) isolated from column chromatography was a white crystalline solid (124mg, 6.6%), which was recrystallised from ether, m.p. 132-134 o C. ¹H NMR (CDCl₃, 270MHz) 1.42 (1H, m), 1.68 (3H, complex m), 2.35 (1H, m), 2.87 (1H, m), 3.11 (1H, m), 3.39 (1H, dm), 3.71 (1H, dt), 4.38 (2H, bs, NH₂), 4.70 (1H, m, CH-azole). ¹³C NMR 20.4 (CH₂), 26.0 (CH₂), 27.6 (CH), 47.2 (CH₂), 47.5 (CH₂), 52.1 (CH₂), 61.3 (CH), 166.1 (azole quat C). MS found 194.1282 C₈H₁₄N₆ requires 194.1280 Analysis C₈H₁₄N₆.¼H₂O Found: C: 47.76; H; 6.82; N: 40.79% Required: C: 47.23; H: 7.38; N: 41.33% Examples 12 to 14 (±) 3-(4-Methyl-1,2,3-triazol-2-yl)-1-azabicyclo[2.2.2]octane hydrochloride (E12) 3-Methanesulphonyloxy-1-azabicyclo[2.2.2]octane (D8) (5.0g, 24.4 mmol) and the sodium salt of 4-methyl-1,2,3-triazole (D21) (5.0g, 2 equivs) were dissolved in dry DMF (150ml) and the reaction carried out as in Example 10. The compound first eluted by column chromatography was the free base of the title compound (E12), (1.1g, 23.5%), which was crystallised as a hydrochloride salt to give the title compound (E12) (m.p. 181-182 o C). ¹H NMR (d₆DMSO, 270MHz) 1.50 (1H, m), 1.70 (1H, m), 1.98 (2H, m), 2.27 (3H, s, azole-Me), 3.24 (4H, bm), 3.38 (1H, m), 3.87 (2H, m), 5.08 (1H, m), 7.68 (1H, s, azole-H). ¹³C NMR (d₆ DMSO) 10.4 (CH₃), 17.3 (CH₂), 20.9 (CH₂), 26.0 (CH), 45.1 (CH₂), 45.4 (CH₂), 48.9 (CH₂), 57.5 (CH), 133.8 (CH-azole), 143.8 (azole quat C). MS: Found 192.1373 C₁₀H₁₆N₄ requires 192.1375 Analysis: C₁₀H₁₆N₄.HCl ¼H₂O Found: C: 51.38; H: 7.34; N: 24.02% Required: C: 51.50; H: 7.51; N: 24.00% Also isolated were the isomers 3-(4-methyl-1,2,3-triazol-3-yl)-1-azabicyclo[2.2.2]octane (E13) and 3-(4-methyl-1,2,3-triazol-1-yl)-1-azabicyclo[2.2.2] octane (E14) which were both crystallised as oxalate salts, (E13) m.p. 151-153 o C, (E14) m.p. 135-140 o C. (E13) ¹H NMR (CDCl₃, 270MHz) 1.75 (2H, tm), 2.08 (2H, bm), 2.36 (1H, m), 2.41 (3H, s, azole-Me), 3.33 (3H, m), 3.52 (1H, m), 3.81 (1H, tm), 5.05 (1H, m, CH-azole), 7.68 (1H, s, azole-H). ¹³C NMR (CDCl₃) 7.8 (CH₃), 17.5 (CH₂), 22.1 (CH₂), 25.7 (CH), 45.5 (CH₂), 45.8 (CH₂), 49.6 (CH₂), 52.0 (CH), 132.9 (C-H-azole), 133.8 (azole quat C). MS: found 192.1377 C₁₀H₁₆N₄ requires 192.1375 (E14) ¹H NMR (d₆ DMSO, 270MHz) 1.66 (1H, m), 1.82 (1H, m), 2.10 (2H, m), 2.35 (3H, s, azole-Me), 2.50 (1H, m), 3.40 (4H, m), 3.94 (1H, m), 4.07 (1H, m), 5.20 (1H, m, CH-azole), 8.18 (1H, s, azole-H). ¹³C NMR (d₆ DMSO) 10.5 (CH₃), 17.2 (CH₂), 21.3 (CH₂), 26.5 (CH), 45.2 (CH₂), 45.4 (CH₂), 48.8 (CH₂), 54.1 (CH), 122.5 (CH-azole), 142.5 (azole quat-C) MS Found 192.1377 C₁₀H₁₆N₄ requires 192.1375 Examples 15 and 16 (±) 3-(Tetrazol-2-yl)-1-azabicyclo[2.2.2]octane hydrochloride salt (E15) (±) 3-(Tetrazol-1-yl)-1-azabicyclo[2.2.2]octane hydrochloride salt (E16) 3-Methanesulphonyloxy-1-azabicyclo[2.2.2]octane (D8) (1.0g, 4.9mmol) was dissolved in dry DMF (50ml) and the sodium salt of 1H-tetrazole (D16) (1.5g, 3.4eq) was added. The reaction was carried out as in Example 10 to yield two separate compounds by column chromatography, the faster running compound being the free base of E15 (80mg, 9%) and the slower running compound being the free base of E16 (60mg, 7%). Both compounds were crystallised as the hydrochloride salts,E15 m.p. 177-180 o C and E16 m.p. 229-230 o C. (E15) ¹H NMR (d₆ DMSO, 270MHz) 1.68 (1H, m), 1.91 (1H, m), 2.19 (2H, m), 2.75 (1H, m), 3.42 (4H, m), 4.06 (2H, m), 5.66 (1H, m, CH-azole), 9.21 (1H, s, azole-H). ¹³C NMR (d₆ DMSO) 17.1 (CH₂), 20.9 (CH₂), 25.7 (CH), 45.1 (CH₂), 45.4 (CH₂), 49.0 (CH₂), 57.4 (CH), 153.4 (azole C-H). MS found 179.1173 C₈H₁₃N₅ requires 179.1171 Analysis: C₈H₁₃N₅.HCl Found: C: 44.10; H: 6.43; N: 32.00% Required: C: 44.5; H: 6.5; N: 32.5% (E16) ¹H NMR (d₆DMSO, 270MHz) 2.00 (2H, m), 2.52 (2H, m), 3.12 (1H, m), 3.43 (6H, complex m), 5.35 (1H, m, CH-azole), 9.08 (1H, s, azole-H). ¹³C NMR (d₆ DMSO) 21.8 (CH₂), 22.8 (CH₂), 38.6 (CH), 49.6 (CH₂), 50.1 (CH₂), 56.2 (CH₂), 60.2 (CH), 153.1 (azole quat C). MS found 179.1171 C₈H₁₃N₅ requires 179.1171 Analysis C₈H₁₃N₅.HCl 1/3 H₂O Found: C: 43.86; H: 6.38; N: 31.18% Required: C: 43.34; H: 6.62; N: 31.60% Example 17 (±) exo-3-(5-Aminotetrazol-2-yl)-1-azabicyclo[3.2.1] octane hydrochloride (E17) endo -3-Methanesulphonyloxy-1-azabicyclo [3.2.1]octane (D12) (600mg, 2.94mmol) and the sodium salt of 5-aminotetrazole (D15) (405mg, 1.5 equiv) were dissolved in dry DMF (30ml) and the reaction carried out as for Example 10. The fraction eluted first from column chromatography (basic alumina, EtOAc/MeOH 1-2%) was the free base of the title compound which was purified as the hydrochloride salt (205mg, 30%) m.p. 262-264 o C (decomp). ¹H NMR (d₆DMSO) 2.19 (3H, m), 2.34 (1H, m), 2.88 (1H, s), 3.50 (5H, complex m), 3.85 (1H, m), 5.35 (1H, m, CH-azole). ¹³C NMR (d₆DMSO) 26.4 (CH₂), 32.6 (CH), 34.1 (CH₂), 50.3 (CH₂), 52.6 (CH), 53.2 (CH₂), 57.3 (CH₂), 167.0 (azole quat carbon) MS: found 194.1280 C₈H₁₄N₆ requires 194.1280 Analysis: C₈H₁₄N₆.HCl 1/8 H₂O Found: C: 41.52; H: 6.63; N: 35.86% Required: C: 41.25; H: 6.55; N: 36.09% Example 18 (±) exo-3-(5-Aminotetrazol-2-yl)-1-azabicyclo[2.2.1] heptane (E18) endo -3-Methanesulphonyloxy-1-azabicyclo[2.2.1]heptane (D10) (0.7g, 3.66mmol) and the sodium salt of 5-aminotetrazole (D15) (1.0g, 2.6 equiv) were dissolved in dry DMF (50ml) and the reaction carried out as in Example 10. The product isolated from column chromatography was a white crystalline solid (70mg, 10.6%), which was recrystallised from ether to give the title compound (E18) (m.p. 132-134 o C). ¹H NMR (CDCl₃, 270MHz) 1.29 (1H, m), 1.77 (1H, m), 2.50 (2H, m), 2.88 (1H, tm), 3.06 (3H, complex m), 3.32 (1H, dm), 4.36 (2H, bs, NH₂), 4.44 (1H, m, CH-azole). ¹³C NMR (CDCl₃) 27.9 (CH₂), 43.4 (CH), 53.7 (CH₂), 58.3 (CH₂), 61.6 (CH₂), 65.8 (CH), 165.9 (azole quat C) MS found 180.1121 C₇H₁₂N₆ requires 180.1123 Analysis C₇H₁₂N₆ Found C: 46.43; H, 6.71; N: 46.17% Required C: 46.65; H: 6.71; N: 46.63% Example 19 (±) exo-3-(Tetrazol-2-yl)-1-azabicyclo[2.2.1]heptane hydrochloride salt (E19) endo -3-Methanesulphonyloxy-1-azabicyclo[2.2.1]heptane (D10) (0.70g, 3.66mmol) and the sodium salt of 1H-tetrazole (D16) (1.0g, 3 equiv) were dissolved in dry DMF (50ml) and the reaction carried out as in Example 10. The resulting product eluted first from column chromatography was a pale yellow oil (70mg, 12%), which was crystallised to give the title compound (E19) as the hydrochloride salt (m.p. 241-245 o C) ¹H NMR (d₆DMSO, 270MHz) 1.92 (1H, m), 2.12 (1H, m), 3.32 (4H, complex), 3.50 (1H, d), 3.84 (1H, dm), 4.00 (1H, dm), 5.51 (1H, m), 9.11 (1H, s, azole-H). ¹³C NMR (d₆DMSO) 23.9 (CH₂), 41.6 (CH), 51.2 (CH₂), 56.8 (CH₂), 57.5 (CH₂), 62.1 (CH), 153.4 (azole-CH). MS: Found 165.1010 C₇H₁₁N₅ requires 165.1006 Analysis C₇H₁₁N₅.HCl Found: C: 41.54; H: 6.04; N: 34.43% Required: C: 41.69; H: 6.00; N: 34.73% Examples 20 and 21 (±) exo-3-(5-Methyltetrazol-2-yl)-1-azabicyclo[2.2.1] heptane hydrochloride salt (E20) (±) exo-3-(5-Methyltetrazol-1-yl)-1-azabicyclo[2.2.1] heptane hydrochloride salt (E21) endo -3-Methylsulphonyloxy-1-azabicyclo[2.2.1] heptane (D10) (0.7g, 3.66mmol) and the sodium salt of 5-methyltetrazole (D17) (0.8g, 2eq) were dissolved in dry DMF (50ml), and the reaction carried out as in Example 10. The compound first eluted by column chromatography was the free base of E20 (90mg, 14%) and was crystallised as the HCl salt (E20) (m.p. 238-239 o C). The compound subsequently eluted was the free base of E21 (50mg, 7.6%), which was crystallised as the hydrochloride salt (E21) (m.p. 246-248 o C). (E20) ¹H NMR (d₆DMSO, 270MHz) 1.93 (1H, m), 2.14 (1H, m), 2.50 (3H, s, azole-Me), 3.38 (5H, complex m), 3.81 (1H, dt), 4.00 (1H, m), 5.43 (1H, m, CH-azole) ¹³C NMR (d₆DMSO) 10.5 (CH₃), 23.9 (CH₂), 41.6 (CH), 51.1 (CH₂), 56.8 (CH₂), 57.4 (CH₂), 61.9 (CH), 162.5 (quat azole-C). MS found 179.1173 C₈H₁₃N₅ requires 179.1171 Analysis C₈H₁₃N₅.HCl ¼H₂O Found: C: 43.84; H: 6.43; N: 31.72% Required: C: 43.64; H: 6.59; N: 31.82% (E21) ¹H NMR (d₆DMSO, 270MHz) 1.97 (1H, m), 2.19 (1H, m), 2.65 (3H, s, azole-Me), 3.44 (4H, complex m), 3.70 (1H, d), 3.82 (1H, dt), 3.98 (1H, m), 5.10 (1H, m, CH-azole). ¹³C NMR (d₆DMSO) 8.6 (CH₃), 24.3 (CH₂), 41.5 (CH), 51.2 (CH₂), 56.4 (CH), 57.0 (CH₂), 58.1 (CH₂), 152.6 (quat azole-C). MS found 179.1171 C₈H₁₃N₅ requires 179.1171 Analysis C₈H₁₃N₅.HCl Found: C: 44.68; H: 6.56; N: 32.48% Required: C: 44.55; H: 6.54; N: 32.47% Example 22 (±) exo-3-(Tetrazol-2-yl)-1-azabicyclo[3.2.1]octane hydrochloride salt (E22) endo -3-Methanesulphonyloxy-1-azabicyclo[3.2.1] octane (D12) (600mg, 2.94 mmol) and the sodium salt of 1H-tetrazole (D16) (405mg, 1.5 equiv) were dissolved in dry DMF (30ml) and the reaction carried out as for Example 10. The fraction eluted first by column chromatography (basic alumina, EtOAc/MeOH 1-2%) was the free base of the title compound which was purified as the hydrochloride salt (170mg, 27%) m.p. 232-234 o C. ¹H NMR (d₆DMSO) 2.28 (3H, m), 2.50 (1H, m), 2.97 (1H, s), 3.31 (1H, m), 3.53 (2H, m), 3.80 (2H, m), 4.02 (1H, m), 5.72 (1H, m, CH-azole), 9.22 (1H, s, azole-H). ¹³C NMR (d₆DMSO) 26.6 (CH₂), 32.9 (CH), 34.5 (CH₂), 50.7 (CH₂), 53.4 (CH₂), 53.7 (CH), 57.6 (CH₂), 153.6 (azole quat carbon). MS: found 179.1168 C₈H₁₃N₅ requires 179.1171 Analysis: C₈H₁₃N₅.HCl Found: C: 44.51; H: 6.59; N: 32.31% Required: C: 44.55; H: 6.54; N: 32.47% Examples 23 and 24 (±) exo-3-(5-Ethyltetrazol-2-yl)-1-azabicyclo[2.2.1] heptane hydrochloride salt (E23) endo -3-Methanesulphonyloxy-1-azabicyclo[2.2.1]heptane (D10) (0.82g, 4.29 mmol) and the sodium salt of 5-ethyltetrazole (D18) (0.60g, 1.2 equiv) were dissolved in dry DMF (25ml) and the reaction carried out as in Example 10. The first product eluted from the column was the free base of the title compound (80mg, 9.7%), which was crystallised as the hydrochloride salt (E23) (m.p. 142-145 o C). ¹H NMR (d₆DMSO, 270MHz) 1.28 (3H, t, Et-CH₃), 1.89 (1H, m), 2.11 (1H, m), 2.86 (2H, q, Et-CH₂), 3.31 (4H, complex m), 3.49 (1H, d), 3.82 (1H, dm), 3.94 (1H, m), 5.39 (1H, m, CH-azole) ¹³C NMR (d₆DMSO) 12.1 (CH₃-ethyl), 18.4 (CH₂), 23.9 (CH₂), 41.5 (CH), 51.3 (CH₂), 56.9 (CH₂), 57.6 (CH₂) 61.9 (CH), 167.2 (azole quat C) Analysis C₉H₁₅N₅.1½HCl Found: C: 43.73; H: 6.50; N: 28.15% Requires: C: 43.60; H: 6.66; N: 28.25% Also isolated by column chromatography was (±) exo -3-(5-ethyltetrazol-1-yl)-1-azabicyclo[2.2.1]heptane (E24) (80mg, 9.7%), which was crystallised as the hydrochloride salt (m.p. 268-270 o C). ¹H NMR (d₆DMSO, 270MHz) 1.28 (3H, t, ethyl-CH₃), 1.90 (1H, m), 2.08 (1H, m), 2.91 (2H, dq, ethyl CH₂), 3.31 (4H, complex m), 3.62 (1H, d), 3.72 (1H, dm), 3.88 (1H, dm), 5.00 (1H, m, CH-azole). ¹³C NMR (d₆DMSO) 10.9 (CH₃), 16.1 (CH₂), 24.3 (CH₂), 41.6 (CH), 51.3 (CH₂), 56.2 (CH), 57.1 (CH₂), 58.3 (CH₂), 156.5 (azole quat C) Example 25 (±) exo-3-(4-Methyl-1,2,3-triazol-2-yl)-1-azabicyclo[2.2.1]heptane hydrochloride salt (E25) endo -3-Methanesulphonyloxy-1-azabicyclo[2.2.1]heptane (D10) (1.0g, 5.24mmol) and the sodium salt of 4-methyl-1,2,3-triazole (D21) (1.13g, 10mmol) were dissolved in dry DMF (50ml) and the reaction carried out as for Example 10. The free base of the product was isolated as a clear colourless oil from column chromatography (basic alumina, eluting with EtOAc/MeOH 1-3%), and was crystallised as the hydrochloride salt (250mg, 22%), m.p. 160-162 o C. ¹H NMR (d₆DMSO) 1.84 (1H, m), 2.06 (1H, m), 2.25 (3H, m, CH₃), 3.29 (5H, complex m), 3.82 (2H, m), 5.03 (1H, m, CH-azole), 7.67 (1H, s, azole-H) ¹³C NMR (d₆DMSO) 10.3 (CH₃), 23.9 (CH₂), 41.7 (CH), 51.2 (CH₂), 56.7 (CH₂), 57.3 (CH₂), 62.7 (CH), 134.0 (CH), 144.0 (azole quat carbon). MS: found 178.1219 C₉H₁₄N₄ requires 178.1218 Analysis: C₉H₁₄N₄.HCl Found: C: 50.26; H: 7.08; 26.10% Required C: 50.35; H: 7.04; N: 25.87% Example 26 (±) endo-3-(5-Aminotetrazol-2-yl)-1-azabicyclo[2.2.1] heptane hydrochloride salt (E26) exo -3-Methanesulphonyloxy-1-azabicyclo[2.2.1]heptane (D22) (400mg, 2.1mmol) and the sodium salt of 5-aminotetrazole (D15) (600mg, 5.61mmol) were dissolved in dry DMF (40ml) and the reaction carried out as in Example 10. The product isolated from column chromatography was a white crystalline solid (60mg, 16%) which was recrystallised as the hydrochloride salt (E26) containing 18% of the hydrochloride salt of the exo isomer (E18) m.p. 216-218 o C (decomp). ¹H NMR (d₆DMSO) 1.39 (1H, m), 2.01 (1H, m), 3.48 (4H, complex m), 3.94 (3H, complex m), 5.53 (1H, m, CH-azole). ¹³C NMR (d₆DMSO) 20.8 (CH₂), 40.9 (CH), 51.7 (CH₂), 53.5 (CH₂), 58.1 (CH₂), 60.0 (CH), 167.3 (quat-C). MS found 180.1125 C₇H₁₂N₆ requires 180.1123 Example 27 (±) 5-(1,2,4-Triazol-1-yl)-1-azabicyclo[3.2.1]octane dihydrochloride salt (E27) (±) 1-Azabicyclo[3.2.1]oct-5-ylhydrazine (D24, 1.34g, assumed 5.3mmol) and Gold's reagent (0.86g, 5.3mmol) were heated at reflux in absolute chloroform (75ml) for 2h. The reaction mixture was cooled and then partitioned between saturated aqueous potassium carbonate solution (75ml) and chloroform (4 x 75ml). The combined organic extracts were dried (Na₂SO₄) and evaporated to yield a gum which was chromatographed on alumina using a graded eluant of 0-2% methanol/chloroform to give the triazole as a low-melting solid (0.50g, 53%). A portion of this material was taken-up in methanol and converted to the dihydrochloride which was recrystallised from methanol/acetone to give the title compound (E27) as a white crystalline solid m.p. 198-200 o C. ¹H NMR (d₆ DMSO) δ: 1.9-2.3 (4H, m), 2.52 (2H, m), 3.30 (2H, m), 3.53 (1H, m), 3.60-3.84 (3H, m), 5.0 (1H, br), 8.30 (1H, s), 9.08 (1H, s), 11.90 (1H, br). ¹³C NMR (d₆ DMSO) δ: 16.89, 32.01, 34.24, 48.95, 50.96, 58.28, 64.05, 142.50, 150.07. Analysis: C₉H₁₄N₄.2HCl requires C: 43.02; H: 6.42; N: 22.31; found C: 42.77; H: 6.35; N: 21.86 Example 28 (±) 5-(3-Methyl-1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octane dihydrochloride salt (E28) (±) 1-Azabicyclo[3.2.1]oct-5-ylhydrazine (D24, 2.61g, assumed 10.5 mmol) was treated with methyl acetimidate hydrochloride (1.15g, 10.5mmol) and triethylamine (1.5ml, 10.8mmol) in dry methanol (75ml) at room temperature for 3h. The reaction mixture was then concentrated in vacuo and anhydrous triethylorthoformate (150ml) and anhydrous pyridine (15ml) were added. The reaction mixture was stirred at room temperature overnight and then refluxed for 3h. The resulting mixture was cooled, evaporated to dryness under reduced pressure, and the residue was partitioned between saturated aqueous potassium carbonate solution (100ml) and chloroform (4 x 100ml). The combined organic extracts were dried (Na₂SO₄) and evaporated to a gum which was chromatographed on silica using 8% methanol/chloroform as eluant to give the methyltriazole as an oil (0.104g, 5%). A portion of this material was taken up in methanol, converted to the dihydrochloride salt, and recrystallised from methanol/acetone to give the title compound (E28) as a white crystalline solid m.p. 165-167 o C. ¹H NMR (d₆DMSO) δ: 1.91-2.24 (4H, m), 2.21 (3H, s), 2.47 (2H, m), 3.28 (2H, m), 3.48 (1H, m), 3.57-3.80 (3H, m), 8.90 (1H, br.s), 11.65 (1H, br.s). MS Calculated mass for C₁₀N₁₆N₄ = 192.1375 Observed mass 192.1375 Examples 29 and 30 (±) 5-(Tetrazol-2-yl)- and (±) 5-(tetrazol-1-yl)-1-azabicyclo[3.2.1]octane oxalate salts (E29) and (E30) (±) 5-Bromo-1-azabicyclo[3.2.1]octane (D23, 1.1g, 5.8mmol) was treated with sodium tetrazole (D16, 1.85g, 20.1mmol) in dry DMF (50ml) at reflux for 5h. The reaction mixture was concentrated in vacuo and the residue partitioned between saturated aqueous potassium carbonate solution (50ml) and chloroform (4 x 75ml). The combined organic extracts were dried and evaporated to give an oil which was chromatographed on silica using 10% methanol/chloroform as eluant to give, in order of elution, the 2-substituted tetrazole as a low-melting solid (0.59g) and the 1-substituted tetrazole as a white solid (0.11g) m.p. 112-114 o C. The 2-substituted tetrazole was converted to the oxalate salt and recrystallised from water/methanol/acetone to give the title compound (E29) as a white solid (0.88g, 57%) m.p. 205-207 o C. The 1-substituted tetrazole was likewise converted to the oxalate salt and recrystallised from methanol to give the title compound (E30) as a white solid (0.15g, 10%) m.p. 184-186 o C (decomp.) (E29) ¹H NMR (d₆DMSO) δ: 1.96 (1H, m), 2.18-2.33 (3H, m), 2.60 (2H, m), 3.24 (2H, m), 3.44 (1H, m), 3.57-3.94 (3H, m), 9.08 (1H, s). ¹³C NMR (d₆DMSO) δ: 17.32, 32.37, 34.83, 49.18, 51.27, 58.75, 67.71, 153.30 Analysis: C₈H₁₃N₅.C₂H₂O₄ requires C: 44.61; H: 5.62; N: 26.01; found C: 44.37; H: 5.60; N: 25.95 (E30) ¹H NMR (d₆DMSO) δ: 1.96 (1H, m), 2.05-2.28 (3H, m), 2.45-2.67 (2H, m), 3.23 (2H, m), 3.44 (1H, m), 3.55-3.83 (3H, m), 9.67 (1H, s). ¹³C NMR (d₆DMSO) δ: 17.24, 32.63, 34.92, 49.07, 51.28, 58.79, 63.79, 142.68 Analysis; C₈H₁₃N₅.C₂H₂O₄ requires C: 44.61; H: 5.62; N: 26.01; found C: 44.43; H: 5.63; N: 25.78 Examples 31 and 32 (±) 5-(5-Methyltetrazol-2-yl)- and (±) 5-(5-methyltetrazol-1-yl)-1-azabicyclo[3.2.1]octane oxalate salts (E31) and (32) (±) 5-Bromo-1-azabicyclo[3.2.1]octane (D23, 0.5g, 2.63 mmol) was treated with the sodium salt of 5-methyltetrazole (D17, 1.27g, 11.98 mmol) in dry DMF (25ml) at reflux for 2.75h. The reaction was worked-up as in the method of Example 29 and 30 and chromatographed on silica using 9% methanol/chloroform as eluant to give, in order of elution, the 2-substituted methyltetrazole as an oil (0.24g, 47%) and the 1-substituted methyltetrazole as a white solid (0.20g, 39%) m.p. 97-100 o C. The 2-substituted methyltetrazole was converted to the oxalate salt and recrystallised from methanol/acetone to give the title compound (E31) as a white crystalline solid m.p. 145-147 o C. The 1-substituted methyltetrazole was similarly converted to the oxalate salt and recrystallised from methanol/acetone to give the title compound (E32) as a white solid m.p. 205-208 o C (decomp.). (E31) ¹H NMR (d₆DMSO) δ: 1.97 (1H, m), 2.10-2.28 (3H, m), 2.48 (3H, s), 2.48-2.68 (2H, m), 3.26 (2H, m), 3.44 (1H, m), 3.66 (1H, m), 3.73 and 3.85 (2H, ABq, J=11Hz). ¹³C NMR (d₆DMSO) δ: 10.46, 17.25, 32.29, 34.67, 49.10, 51.21, 58.65, 67.40, 162.39. Analysis: C₉H₁₅N₅.C₂H₂O₄ requires C: 46.64; H: 5.62; N: 24.72; found C: 46.50; H: 6.04; N: 24.40. (E32) ¹H NMR (d₆DMSO) δ: 1.84-2.20 (4H, m), 2.50 (1H, m), 2.61 (3H, s), 2.77 (1H, m), 3.25 (2H, m), 3.43 (1H, m), 3.58 (1H, m), 3.87 (2H, m). ¹³C NMR (d₆DMSO) δ: 9.70, 17.41, 31.39, 34.60, 49.20, 51.04, 58.81, 64.02, 151.71. Analysis: C₉H₁₅N₅.C₂H₂O₄ requires C: 46.64; H: 5.62; N: 24.72; found C: 46.39; H: 6.06; N: 24.39. Examples 33 and 34 (±) 5-(5-Aminotetrazol-2-yl)- and (±) 5-(5-aminotetrazol-1-yl)-1-azabicyclo[3.2.1]octane (E30) and (E31) (±) 5-Bromo-1-azabicyclo[3.2.1]octane (D23, 0.5g, 2.63mmol) was treated with the sodium salt of 5-aminotetrazole (D15, 0.56g, 5.23mmol) in dry DMF (15ml) at reflux for 1h. The reaction was worked-up as in the method of Example 29 and 30 and chromatographed on silica using a graded eluant of 12-20% methanol/chloroform. This gave, in order of elution, the 2-substituted aminotetrazole (E33), which was recrystallised from methanol/ether to give a white solid (0.13g, 24%) m.p. 173-175 o C, and the 1-substituted aminotetrazole (E34) (0.07g, 14%). m.p. 220-223 o C (decomp.). (E33) ¹H NMR (CO₃OD) δ: 1.77 (1H, m), 1.94-2.26 (1H, m), 2.22 (2H, m), 2.41 (2H, t, J=9Hz), 2.86 (2H, m), 3.06 (1H, m), 3.18-3.36 (3H, m), 4.90 (2H, br). ¹³C NMR (CD₃OD) δ: 21.33, 36.66, 37.88, 52.03, 55.04, 63.78, 70.28, 168.80. λmax 247nm (ε3570, EtOH) M.S. Calculated mass for C₈H₁₄N₆ = 194.1280 Observed mass = 194.1278 (E34) ¹H NMR (CD₃OD) δ: 1.71 (1H, m), 1.96 (2H, m), 2.07-2.22 (2H, m), 2.70 (1H, m), 2.89 (2H, m), 3.06 (1H, m), 3.18-3.37 (2H, m), 3.46 (1H, m), 4.80 (2H, br). ¹³C NMR (CD₃OD) δ: 20.80, 34.45, 35.71, 51.73, 54.39, 63.21, 64.77, 156.50 λmax 219nm (ε3530, EtOH) M.S. Calculated mass for C₈H₁₄N₆ : 194.1280 Observed mass = 194.1282 Example 35 (±) 3-(1,2,3-triazol-1-yl)-1-azabicyclo[2.2.2]octane (E35) (±) 3-Azido-1-azabicyclo[2.2.2]octane oxalate salt (D25) (200mg, 0.0083 mole) in acetone (20ml) was treated with acetylene dicarboxylic acid (500mg, 0.0044 mole) and concentrated in vacuo to produce a homogenous gum. Xylene (20ml) was added and the solution heated to reflux for 10 min when the suspension rapidly darkened and evolved carbon dioxide. The xylene was then removed in vacuo and the residue partitioned between chloroform and saturated aqueous potassium carbonate solution. The organic phase was separated, dried over sodium sulphate and concentrated in vacuo to a gum. Chromatography on alumina in a gradient of 5-30% methanol in ethyl acetate afforded the title compound (E35) which crystallised from 40-60 o petrol as needles m.p. 62-65 o C (60mg, 0.0034moles, 40%). ¹H NMR (270MHz, CDCl₃) δ: 1.3-1.48 (1H, m), 1.48-1.63 (1H, m), 1.63-1.82 (2H, m), 2.1-2.25 (1H, m), 2.75-2.95 (3H, m), 2.95-3.15 (1H, m), 3.33-3.48 (1H, m), 3.53-3.68 (1H, m), 4.5-4.65 (1H, m), 7.55 (1H, s), 7.68 (1H, s). ¹³C NMR (CDCl₃, 68 MHz) δ: 19.9 and 25.9 (C-5,7), 28.1 (C-4), 46.9, 47.2 and 52.7 (C-2,6,8), 58.1 (C-3), 122.7 and 133.7 (C-4′ and C-5′) Example 36 and 37 (±) 5-(3-Amino-1,2,4-triazol-1-yl)- and (±) 5-(5-amino-1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octanes (E36) and (E37) (±) 5-Bromo-1-azabicyclo[3.2.1]octane (D23, 2g, 10.5 mmol) was treated with the sodium salt of 3-amino-1,2,4-triazole (D20, 2.23g, 21.0 mmol) in dry DMF for 1h. The reaction was worked-up as in the method of Example 29 and 30 and chromatographed on basic alumina using a graded eluant of 0-2% methanol/chloroform to give, in order of elution, the 3-aminotriazole (E36), which was recrystallised from methanol/ether to give a white solid (0.29g, 14%) m.p. 172-174 o C, and the 5-aminotriazole (E37) as a white solid (0.28g, 14%) m.p. 190-194 o C. E36 ¹H NMR (CDCl₃) δ: 1.72 (1H,m), 1.90 (1H,m), 2.09 (2H,m), 2.22 (2H,m), 2.74-3.05 (4H,m), 3.27-3.36 (2H,m), 4.20 (2H,br.s), 7.68 (1H,s) ¹³C NMR (CDCl₃) δ:20.40, 35.82, 37.04, 51.25, 54.19, 63.50, 64.53, 139.69, 163.19. E37 1H NMR (CDCl₃/DMSO) δ: 1.64 (1H,m), 1.87 (2H,m), 2.10 (2H,m), 2.51 (1H,m), 2.75-3.20 (4H,m), 3.18-3.36 (2H,m), 5.27 (2H,br.s), 7.32 (1H,m). ¹³C NMR (CDCl₃/DMSO) δ: 19.51, 33.98, 34.34, 50.61, 53.03, 62.64, 77.24, 146.85, 153.38. Example 38 and 39 (±)3-(3-Amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane (E38) and (±) 3-(5-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane dihydrochloride salt (E39) (±) 3-Methanesulphonyloxy-1-azabicyclo[2.2.2]octane (D8) (5.0g, 0.024 mol) and the sodium salt of 3-amino-1,2,4-triazole (D20) (7.0g, 0.066 mol) in dry DMF was heated at reflux for 1.5h, and the reaction carried out as in Example 10. The mixture was purified by column chromatography using basic alumina eluting with chloroform/methanol (0-2%), to give, in order of elution, E38 which was recrystallised from EtOAc/40-60 petrol to give a white solid (150 mg, 3.2%) m.p. 144-146 o C and E39 which was crystallised from methanol/ether as the dihydrochloride salt (110 mg, 1.7%) m.p. 257-259 o C. E38 ¹H NMR (CDCl₃) δ: 1.43 (1H,m), 1.78 (1H, complex m), 2.05 (2H,m), 2.18 (1H,m), 2.89 (3H,m), 3.05 (1H,m), 4.08 (2H,m,NH₂), 4.2 (1H,m,CH-azole), 7.73 (1H,s,azole-H). ¹³C NMR (CDCl₃) 20.2 (CH₂), 26.8 (CH₂), 27.5 (CH), 46.9 (CH₂), 47.42 (CH₂), 52.4 (CH₂), 56.8 (CH), 141.9 (azole-CH), 163.1 (quat-C). MS C₉H₁₅N₅ requires 193.1327 found: 193.1331. E39 ¹H NMR (d₆DMSO): 1.89 (4H,m), 2.31 (1H,s), 3.25 (4H,m), 3.55 (1H,dd), 3.73 (1H,dt), 5.03 (1H,m), 8.40 (1H,s, azole-H) ¹³C NMR (d₆DMSO): 17.0 (CH₂), 20.8 (CH₂), 24.5 (CH), 44.8 (CH₂), 45.5 (CH₂), 48.1 (CH₂), 50.6 (CH), 138.8 (CH-azole), 149.5 (quat C azole). MS C₉H₁₅N₅ requires 193.1327, found 193.1327. Example 40 (±) 3-[5-Bromotetrazol-2-yl]-1-azabicyclo[2.2.2]octane oxalate salt (E40) Tertiary butyllithium in pentane (7ml of a 1.7 molar solution, 0.0104 mole) in dry pentane (25ml) at -65 o C under nitrogen was treated with 3-(tetrazol-2-yl)-1-azabicyclo[2.2.2]octane (the free base of E15) (1.0g; 5.2 mmole) in a dry pentane (50ml)/dry THF (10ml) mixture, maintaining an internal temperature of -65 o C. Stirring was continued for 10 minutes. Bromine (2eq, 1.66g, 10.4 mmole) in dry pentane (5ml) was then added dropwise. The mixture was then immediately quenched with glacial acetic acid (2eq, 0.62ml, 10.4 mmole), then partitoned between aqueous potassium carbonate (20ml) and chloroform (5 x 20ml). The combined organic extracts were dried (Na₂SO₄) and concentrated in vacuo , to afford an oil which was chromatographed on neutral alumina eluting with ethyl acetate, to afford in order of elution the title compound (free base) (220mg as an oil) and unreacted starting material. The free base was converted to the oxalate salt and recrystallised from acetone/ether to give the title compound (E40) as a white crystalline solid (0.113g, 0.00032 mole, 6%) m.p. 165 o C (decomp.). ¹H NMR (DMSO) δ: 1.58-1.78 (2H, m), 1.90-2.03 (2H, m), 2.52-2.61 (1H, m), 3.12-3.25 (4H, m), 3.78-3.84 (2H, d, J=5.5Hz), 5.39-5.50 (1H, m). ¹³C NMR (DMSO) δ: 18.4 and 22.4 (C-5, 8), 27.4 (C-4), 47.3, 47.6 and 50.8 (C-2,6,7), 60.3 (C-3), 144.1 (C-5′), 166.7 ((CO₂H)₂) Example 41 (±) exo-3-(5-Bromotetrazol-2-yl)-1-azabicyclo[2.2.1] heptane oxalate salt (E41) (±) exo -3-(Tetrazol-2-yl)-1-azabicyclo[2.2.1]heptane (the free base of E19) (0.38g, 2.3mmol) in dry THF (20ml) was added dropwise under nitrogen to a stirred solution of tertiary butyllithium (2.55ml of a 1.7M solution in pentane, 4.3mmol, 2 eqs) in dry pentane (10ml) at -65 o C under nitrogen maintaining the temperature below -40 o C throughout the addition. The yellow precipitate was stirred at -65 o C for 5 minutes. Bromine (0.22ml, 4.3mmol, 2 eq) in pentane (10ml)/THF (10ml) was added dropwise, immediately followed by quenching with glacial acetic acid (0.26ml, 2 eq) and the mixture allowed to warm to 0 o C. Saturated aqueous potassium carbonate (30ml) was added, the solution extracted with CHCl₃, the organic extracts dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield a yellow oil. This was purified by column chromatography (b Al₂O₃, EtOAc/1-5% MeOH) to yield the required compound (0.37g, 67%) which was crystallised from methanol/diethyl ether as oxalate salt to afford the title compound (E41) m.p. 144-146 o C. ¹H NMR (d₆ DMSO) 1.83 (1H, m), 2.00 (1H, m), 3.04 (2H, d), 3.23 (3H, complex m), 3.67 (2H, m), 5.30 (1H, m) ¹³C NMR (d₆ DMSO) 24.7 (CH₂), 41.9 (CH), 51.7 (CH₂), 57.1 (CH₂), 58.2 (CH₂), 64.1 (CH), 142.3 (azole C-Br), 163.6 (oxalate). Analysis: C₇H₁₀N₅B r .C₂H₂O₄ requires: C 32.35; H 3.62; N 20.96% found: C 32.36; H 3.63; N 20.65% Example 42 (±) exo-3-(5-Chlorotetrazol-2-yl)-1-azabicyclo[2.2.1] heptane oxalate salt (E42) This synthesis was carried out as for Example 41 but using a solution of chlorine gas (2 eqs) in CCl₄ instead of bromine to quench the tetrazole anion. The resulting crude oil was purified by column chromatography (b.Al₂O₃. EtOAc/1-5% MeOH) to yield the chlorotetrazole (0.30g, 65%) which was crystallised from methanol/diethyl ether as an oxalate salt to afford the title compound (E42), m.p. 125-128 o C. ¹H NMR (d₆ DMSO) 1.73 (1H, m), 2.00 (1H, m), 3.05 (2H, m), 3.21 (1H, m), 3.31 (2H, t), 3.71 (2H, complex m), 5.28 (1H, m). ¹³C NMR (d₆ DMSO) 24.7 (CH₂), 41.6 (CH), 51.6 (CH₂), 57.0 (CH₂), 58.3 (CH₂), 64.3 (CH), 154.3 (azole C-Cl), 163.7 (oxalate). M.S. C₇H₁₀N₅Cl requires 199.0624 found 199.0631 Analysis: C₇H₁₀N₅Cl.C₂H₂O₄ requires C, 37.36; H, 4.18; N, 24.22% found C, 37.26; H, 4.22; N, 24.03% Example 43 (±) exo-3-(5-Iodotetrazol-2-yl)-1-azabicyclo[2.2.1] heptane oxalate salt (E43) This synthesis was carried out as for Example 41 but using iodine (0.93g, 2 eq) in THF (20ml) instead of bromine to quench the tetrazole anion. The resulting crude oil was purified by column chromatography (b.Al₂O₃, EtOAc/MeOH 1-5%) to yield the iodotetrazole (0.281g, 42%) which was crystallised from methanol/diethyl ether as an oxalate salt to afford the title compound (E43), m.p. 158-161 o C ¹H NMR (d₆ DMSO) 1.83 (1H, m), 2.08 (1H, m), 3.13 (2H, d), 3.33 (3H, complex m), 3.78 (2H, m), 5.38 (1H, m). ¹³C NMR (d₆ DMSO) 24.8 (CH₂), 41.9 (CH), 51.7 (CH₂), 57.1 (CH₂), 58.6 (CH₂), 63.6 (CH) 115.5 (azole C-I), 163. 7 (oxalate). Example 44 (±) 3-(5-Chlorotetrazol-2-yl)-1-azabicyclo[2.2.2]octane oxalate salt (E44) Tertiary butyllithium (a solution of 1.7 molar in pentane) (7ml; 10.4mmole, 2eq) in dry hexane (25ml) at -65 o C under nitrogen was treated with 3-(tetrazol-2-yl)-1-azabicyclo[2.2.2]octane (the free base of E15) (1g; 5.2mmole) in dry tetrahydrofuran (25ml) maintaining an internal temperature of less than -50 o C throughout the addition. The resulting yellow solution was stirred at -60 o C for 10 minutes before treatment with chlorine (2eq; 0.74g; 10.4mmole) in dry hexane (20ml) at -60 o C over a period of 5 minutes. After complete addition the reaction mixture was quenched with glacial acetic acid (2 eq), then partitioned between aqueous potassium carbonate and chloroform. The organic extracts were dried over sodium sulphate, then concentrated under reduced pressure to afford an orange oil. Column chromatography on silica in a gradient of 2-10% methanol in chloroform, afforded the title compound and a slower running impurity. Further chromatography on neutral alumina in neat ethyl acetate afforded the pure title compound as an orange oil which was crystallised from methanol/diethyl ether as an oxalate salt (E44) (0.139g; 10%), m.p. (dec) 127-129 o C. ¹H NMR (CD₃OD) δ: 1.80-2.04 (2H, m), 2.18-2.28 (2H, m, 5-C, 7-C), 2.70-2.78 (H, m, 4-C) 3.39-3.61 (4H, m, 6-C, 8-C), 3.95-4.28 (2H, m, 2-C), 5.52-5.62 (H, m, 3-C). ¹³C NMR (CD₃OD) δ: 17.32, 21.43 (both CH₂, 5, 7), 25.44 (CH, 4), 45.28 (CH₂, 6), 45.62 (CH₂, 8), 49.78 (CH₂, 2), 59.16 (CH, 3), 154.34 (azole C-Cl), 163.87 (oxalate). Example 45 (±) 3-(5-Iodotetrazol-2-yl)-1-azabicyclo[2.2.2]octane (E45) Tertiary buthyllithium (1.7 molar solution in pentane) (2 eq; 8.6ml; 12.8 mmole) in dry hexane (25ml) under nitrogen at -65 o C was treated with 3-(tetrazol-2-yl)-1-azabicyclo[2.2.2]octane (the free base of E15) (1.254g; 6.4mmole) in dry tetrahydrofuran (50ml) maintaining an internal temperature of -60 to -65 o C thoughout the addition. The resulting yellow solution was stirred at -60 o C for 10 minutes before treatment with iodine (2eq; 3.25g; 12.8mmole) in dry hexane (10ml) over 5 minutes at -60 o C. The reaction mixture was immediately quenched with glacial acetic acid (2 eq), then partitioned between aqueous potassium carbonate and chloroform. The combined chloroform extracts were dried over sodium sulphate, and washed with sodium metabisulphite to remove the free iodine. The solution was concentrated under reduced pressure to afford a crude yellow gum which was purified by column chromatography on silica gel in a gradient of 2-7% methanol in chloroform. Elution with 6% methanol in chloroform gave the major fraction as a gum which was triturated with ether in methanol to afford the title compound (E45) (0.028g, 1.5%), m.p. 160-165 o C (Dec). ¹H NMR (CD₃OD) δ: 1.63-1.85 (2H, m), 2.05-2.12 (2H, m, 5-C and 7-C), 2.58-2.62 (H, m, 4C), 3.20-3.39 (4H, m, 6-C and 8-C), 3.78-3.86 (1H, m, 2-C), 3.95-4.02 (1H, m, 2-C), 5.39-5.45 (1H, m, 3-C). ¹³C NMR (CD₃OD) δ: 19.2, 23.8 (both CH₂, 7-C and 5-C), 27.9 (CH₂, 4-C), 47.5, 47.9, 51.5 (all CH₂, 2-C, 6-C, 8-C), 61.0 (CH, 3-C), 114.4 (azole C-I) Example 46 (±) 3-(5-Cyanotetrazol-2-yl)-1-azabicyclo[2.2.2]octane oxalate salt (E46) A 1.7 molar solution of t-butyllithium in pentane (1.2 eq; 4.54ml; 6.7mmol) was diluted with dry hexane (10ml) under nitrogen and cooled to -65 o C. The cold solution was treated with 3-(tetrazol-2-yl)-1-azabicyclo[2.2.2] octane (free base of E15) (1g, 5.6mm) in dry tetrahydrofuran (20ml) dropwise, maintaining an internal temperature below -50 o C. The resulting yellow precipitate was then treated with N-methylformanilide (1.2eq; 0.9g, 6.7mmol) in dry tetrahydrofuran (10ml), dropwise maintaining an internal temperature of below -50 o C. Stirring at this temperature was continued for 30 minutes. The cold reaction mixture was then poured into dilute hydrochloric acid (25ml) and stirred for 10 minutes. The reaction mixture was basified with aqueous potassium carbonate and extracted into chloroform. The combined organic extracts were (Na₂SO₄) and evaporated to dryness under reduced pressure. The resulting crude aldehyde was dissolved in methanol (10ml) and treated with hydroxylamine hydrochloride (1.1eq; 0.43g, 6.14mmol) at room temperature. Stirring was continued for 5 hours. The mixture was concentrated in vacuo to a gum which was treated with saturated aqueous potassium carbonate, and the aldoxime extracted into chloroform. The combined organic extracts were dried (Na₂SO₄) and evaporated to dryness under reduced pressure to a gum. The resulting crude aldoxime was dissolved in acetic anhydride (20ml) and heated at 80 o C for 1 hour. After cooling acetic anhydride was removed in vacuo and the resulting viscous oil was treated with aqueous potassium carbonate and extracted with chloroform. Combined organic extracts were dried (Na₂SO₄) and evaporated to dryness under reduced pressure to a gum. Column chromatography (neutral alumina, eluting with 1% methanol in ethyl acetate) afforded a yellow oil which was crystallised as an oxalate salt from acetone/ether, to afford the title compound (E46) (0.088g, 5.4%) as colourless needles. m.p. 175 o C (Dec). ¹H NMR (CD₃OD) δ: 1.66-1.93 and 2.08-2.20 each (2H, m, 5-CH₂ and 7-CH₂), 2.64-2.72 (1H, m, 4-H), 3.22-3.45 (4H, m, 6-CH₂ and 8-CH₂), 3.85-4.09 (2H, m, 2-CH₂), 5.55-5.64 (1H, m, 3-CH). ¹³C NMR (CD₃OD) δ: 18.86, 23.35 (C5 and C7), 27.74 (C4), 47.25 (C6), 47.63 (C8), 51.35 (C2), 61.76 (C3), 110.19 (nitrile C), 143.56 (C5′), 167.74 (oxalate). Example 47 (±) 3-(3-Bromo-1,2,4-triasol-1-yl)-1-azabicyclo[2.2.2]octane oxalate salt (E47) (±) 3-(3-Amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane (E38) (100mg, 0.52 mmol) in 30% hydrobromic acid (25ml) was cooled to below 0 o C on a MeOH/ice bath, and stirred while a solution of sodium nitrite (40mg, 0.58 mmol) in water (2ml) was slowly added and the mixture stirred for 5 minutes. The cold orange solution was added dropwise to a cold solution of cuprous bromide (81mg, 0.58 mmol) and allowed to stand for 5 min. The dark blue/black solution was heated to 80 o C until nitrogen evolution ceased and then allowed to cool. Saturated aqueous potassium carbonate solution was added and the aqueous phase extracted several times with ethyl acetate. The organic extracts were dried (Na₂SO₄), filtered and evaporated to dryness under reduced pressure to yield an orange oil which was purified by column chromatography (basic Al₂O₃, EtOAc/MeOH 1-5%), to yield a colourless oil (40mg, 29%) which was crystallised as an oxalate salt from methanol/diethyl ether to give a white crystalline solid. m.p. 128-130 o C. ¹H NMR (d₆ DMSO) δ: 1.74 (2H, m), 1.93 (2H, m), 2.40 (1H, m), 3.19 (3H, m), 3.31 (1H, m), 3.64 (1H, dd), 3.75 (1H, t), 4.96 (1H, m), 8.76 (1H, s, azole-H) ¹³C NMR (d₆ DMSO) δ: 17.4 (CH₂), 21.9 (CH₂), 26.1 (CH), 45.2 (CH₂), 45.8 (CH₂), 49.4 (CH₂), 54.2 (CH), 138.5 (quat-C, azole), 146.2 (CH-azole), 164.2 (oxalate). MS: 256.0326 C₉H₁₃N₄Br requires 256.0323 Example 48 (±) 3-(3-Chloro-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2] octane oxalate salt (E48) (±) 3-(3-Amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane (E38) (239mg, 1.24 mmol) was converted to the 3-chlorotriazole according to the method of Example 47, using concentrated hydrochloric acid (30ml), sodium nitrite (184mg, 2.6mmol) and cuprous chloride (264mg, 2.6mmol). The resulting oil was purified by column chromatography (basic Al₂O₃, EtOAc/MeOH (1-5%)) and the product (110mg, 41%) crystallised from methanol/diethyl ether as an oxalate salt. m.p. 119-121 o C. ¹H NMR (d₆ DMSO) δ: ¹³C NMR (d₆ DMSO) δ: MS: Found 212.0829 C₉H₁₃N₄Cl requires 212.0828 Analysis:- C₉H₁₃N₄Cl.C₂H₂O₄ found: C: 43.48; H: 4.78; N: 18.21% required: C: 43.64; H: 5.00; N: 18.51% Example 49 (±) 5-(5-Chlorotetrazol-2-yl)-1-azabicyclo[3.2.1]octane oxalate salt (E49) 5-(Tetrazol-2-yl)-1-azabicyclo[3.2.1]octane (the free base of E29) (0.25g, 1.40 mmol) was converted to the 5-chlorotetrazole according to the method of Example 42. Chromatography on silica using 3% methanol/chloroform afforded the 5-chlorotetrazole as an off-white solid (0.15g, 50%) m.p. 72-74 o C. This material was converted to an oxalate salt and recrystallised from methanol/acetone to afford the title compound (E49) as a white crystalline solid, m.p. 189 o C (decomp.). ¹H NMR (d₆ DMSO, 270 MHz) δ: 1.87-2.34 (4H, m), 2.60 (2H, m), 3.23 (2H, m), 3.53 (1H, m), 3.52-3.74 (2H, m), 3.81 (1H, m) ¹³C NMR (d₆ DMSO, 270MHz) δ: 17.40, 32.20, 34.48, 49.20, 51.31, 58.74, 69.10, 154.30 MS Calculated mass for C₈H₁₂N₅Cl = 213.0781 Observed mass = 213.0782 Example 50 (±) 5-(5-Bromotetrazol-2-yl)-1-azabicyclo[3.2.1]octane (E50) 5-(Tetrazol-2-yl)-1-azabicyclo[3.2.1]octane (the free base of E29) (0.2g, 1.12mmol) was converted to the 5-bromotetrazole according to the method of Example 40. Chromatography on silica using 4% methanol/chloroform afforded the title compound (E50) as a white crystalline solid (0.16g, 56%) m.p. 108-110 o C. ¹H NMR (CDCl₃, 270MHz) δ: 1.72-2.05 (2H, m), 2.28 (2H, m), 2.46 (2H, m), 2.80-3.08 (3H, m), 3.22-3.41 (3H, m). ¹³C NMR (CDCl₃) δ: 20.74, 36.28, 37.10, 51.53, 54.30, 63.92, 70.81, 142.68 M.S. Calculated mass for C₈H₁₂N₅Br = 257.0275, 259.0255 Observed mass 257.0280, 259.0256 Analysis: C₈H₁₂N₅Br requires C: 37.23, H: 4.69, N: 27.13% found C: 37.69, H: 4.57, N: 27.06% Example 51 4-(1,2,4-Triazol-1-yl)-1-azabicyclo[2.2.1]heptane oxalate salt (E51) A stirred solution of 1-benzyl-4-hydroxymethyl-4-(1,2,4-triazol-1-yl)piperidine (D29, 320mg, 0.0018mol) in dry pyridine (5ml) at 0 o C was treated with 4-toluenesulphonyl chloride (225mg, 0.00118 mol) and the resulting red solution kept at 5 o C for 20h, followed by room temperature for 3 days. The solution was concentrated in vacuo and the residue treated with saturated potassium carbonate solution and extracted with chloroform (3 x 30ml). The combined extracts were dried (Na₂SO₄) and concentrated in vacuo to leave an orange oil, which was treated with toluene (30ml) and heated under reflux for 2h. The toluene solution was decanted off and the orange gum remaining was dissolved in ethanol (40ml) together with glacial acetic acid (1ml) and hydrogenated over 10% palladium/charcoal (200mg) at atmospheric pressure and 40 o C until reduction was complete (1h). The catalyst was removed by filtration through Kieselguhr and the filtrate concentrated in vacuo . The residue was basified with saturated potassium carbonate solution and extracted with chloroform (3 x 30ml). The combined extracts were dried (Na₂SO₄) and concentrated in vacuo to leave a yellow oil, which was filtered through a plug of basic alumina eluting with ethyl acetate to give a colourless oil, which crystallised on standing. This was converted to an oxalate salt and crystallised from methanol/ether to afford the title compound (E51) as a white solid (42mg, 14%) m.p. 142-144 o C. ¹H NMR (d₆ DMSO, 250 MHz) δ: 2.20-2.50 (4H, m), 3.33-3.46 (2H, m), 3.48-3.65 (4H, m), 8.11 (1H, s), 8.77 (1H, s). ¹³C NMR (d₆ DMSO, 67.8MHz) δ: 32.33, 52.67, 59.43, 66.39, 143.61, 151.77, 164.05 (COOH)₂. Required C: 47.24 H: 5.51 N: 22.05 Found C: 47.03 H: 5.57 N: 22.01 Example 52 (±) exo-3-(3-Amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane (E52) and (±) exo-3-(5-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane (E55) endo -3-(Methanesulphonyloxy)-1-azabicyclo[2.2.1]heptane (D10) (4.21g; 0.035 mole) was dissolved in dry dimethylformamide (100ml), and treated with the sodium salt of 3-amino-1,2,4-triazole (D20) (1.5eq; 5.3g; 0.05 mole). The mixture was heated at reflux for 1 hour, then allowed to cool to room temperature. Dimethylformamide was removed in vacuo and the resulting residue treated with aqueous potassium carbonate and extracted exhaustively into chloroform. Combined organic extracts were dried (Na₂SO₄), then concentrated in vacuo to leave a crude orange oil. This was purified by column chromatography (basic alumina, 10-20% methanol/chloroform) to yield separately the less polar title compound (E52) (0.633g) and the more polar compound (E55) (0.604g). Both were crystallised from acetone to give white crystalline solids (total yield 1.237g, 20%). E52 m.p. 150-152 o C ¹H NMR (270MHz, CDCl₃) δ: 1.21 (1H, m), 1.74 (1H, m), 2.47 (2H, m), 2.87 (2H, complex m), 3.08 (3H, complex m), 3.92 (1H, m), 4.3 (2H, bs, NH₂), 7.72 (1H, s, azole-H). E55 m.p. 171 o C (decomp). ¹H NMR (270MHz, CD₃OD) δ: 1.49 (1H, m), 1.75 (1H, m), 2.42 (1H, d), 2.55 (1H, m), 2.69 (1H, d), 2.82 (1H, m), 3.04 (1H, complex m), 3.20 (2H, d), 4.02 (1H, m), 7.39 (1H, s, azole-H). Example 53 (±) exo-3-(3-Chloro-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane hydrochloride salt (E53) (±) exo -3-(3-Amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane (E52) (150mg, 0.84 mmol) was converted to the 3-chlorotriazole according to the method of Example 48. The resulting oil was purified by column chromatography (basic Al₂O₃, 1-5% MeOH/EtOAc) and the product (73mg, 44%) was crystallised from methanol/diethyl ether as the hydrochloride salt. ¹H NMR (270MHz, DMSO) δ: 1.66-1.8 (1H, m, 5H), 2.0-2.16 (1H, m, 5H), 3.13-3.9 (7H, m), 4.87-5.0 (1H, m, 3H), 8.78 (1H, s, 5′H). ¹³C NMR (67MHz, DMSO) δ: 24.3 (C-5), 41.5 (C-4), 51.0, 56.7 and 57.4 (C2, 6 and 7), 59.0 (C-3), 146.2 (C-5′), 151.0 (C-3′). Example 54 (±) exo-3-(3-Bromo-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane oxalate salt (E54) A mixture of of (±) exo -3-(3-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane (E52) and (±) exo -3-(5-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane (0.15g; 0.84 mmole) (E55) was dissolved in 49% hydrobromic acid (6ml) at 0 o C. This cold solution was treated with sodium nitrite (1.2eq; 0.07g; 1.0mmole) in water (3ml). After stirring for 5 minutes this mixture was added dropwise to a cold suspension of copper (1) bromide (1.2eq; 0.29g; 1.0mmole) in water (10ml) and the mixture stirred for a further 5 minutes. The resulting blue solution was gently heated to 80 o C, and this temperature was maintained until nitrogen gas ceased to evolve. The resulting brown solution was allowed to cool to room temperature, treated carefully with anhydrous potassium carbonate, and the resulting blue solution was extracted using chloroform. Combined organic extracts were dried (Na₂SO₄) then concentrated in vacuo to give an orange oil which crystallised on standing (60mg, 29%). ¹H NMR (CDCl₃, 270MHz) δ: 1.2-1.33 (1H, m, 5-H), 1.7-1.85 (1H, m, 5-H), 2.42-2.58 (2H, m), 2.82-2.98 (2H, m), 2.98-3.22 (3H, m), 4.05-4.13 (1H, m, 3-H), 8.0 (1H, s, 5′H). ¹³C NMR (CDCl₃, 67MHz) δ: 28.2 (C-5), 43.4 (C-4), 58.3, 62.0, 63.2 (C-2,6,7), 139.8 (C-3′) and 143.3 (C-5′). The product was crystallised from methanol/diethyl ether as an oxalate salt to give the title compound (E54) as a low melting crystalline solid. ¹H NMR (CD₃OD, 400MHz) (oxalate) δ: 1.71-1.85 (1H, m, 5-H), 2.08-2.20 (1H, m, 5-H), 3.09 (1H, d), 3.35-3.45 (1H, m), 3.8-3.9 (1H, m), 4.85-4.9 (1H, m, 3-H), 8.4 (1H, s, 5-H). ¹³C NMR (CD₃OD, 100.6MHz) (oxalate) δ: 21.8 (C-5), 43.9 (C-4), 53.4, 58.9 and 59.7 (C-2, 6 and 7), 60.6 (C-3), 140.94 (C-3′) and 147.5 (C-5′) Example 56 4-(3-Methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane oxalate salt (E56) The title compound (E16) was prepared from 1-benzyl-4-hydroxymethyl-4-(3-methyl-1,2,4-triazol-1-yl)piperidine (D31) using the method given in Example 51, as a hydroscopic white solid (6%). ¹H NMR (CD₃OD, 250MHz) δ: 2.35 (3H, s), 2.38-2.70 (4H, m), 3.50-3.70 (2H, m), 3.70-3.94 (4H, m), 8.57 (1H, s) Example 57 (±) exo-3-(3-Azido-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane oxalate salt (E57) (±) exo -3-(3-Amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane (E52) (126mg, 0.0007 moles) in 1N sulphuric acid (5ml) was cooled to 0 o C and treated with sodium nitrite (53mg, 0.00077 moles) in water (1ml). The solution was allowed to stand at 0 o C for 10 min and then treated with sodium azide (91mg, 0.0014 moles) at 0 o C. The solution was allowed to warm to 25 o C over a period of 1h. The solution was then adjusted to pH 11 with solid potassium carbonate and the aqueous solution extracted with chloroform. The organic phase was separated, dried (Na₂SO₄) and concentrated in vacuo to a gum. The gum was then chromatographed on alumina in a gradient of 2-5% methanol in ethyl acetate. The first fraction which eluted in 3% methanol in ethyl acetate was concentrated in vacuo to afford a gum (70mg). The oxalate salt crystallised from acetone as cubes (E17) (49mg, 0.000166 moles, 23%), m.p. 148-150 o C. ¹H NMR (270MHz, CD₃OD) δ: 1.8-2.0 (1H, m, 5-H), 2.13-2.33 (1H, m, 5H), 3.15 (1H, d, J=3Hz), 3.25-3.4 (3H, m), 3.4-3.6 (1H, m), 3.75-3.9 (2H, m), 3.9-4.02 (1H, d, J=8Hz), 8.43 (1H, s, 5′-H). ¹³C NMR (67.8MHz, CD₃OD) δ: 25.9 (C-5), 43.9 (C-4), 53.3, 58.9 and 59.5 (C-2,6,7), 60.4 (C-3), 146.5 (C-5′), 159.9 (C-3′) and 166.6 (CO₂H)₂. Example 58 (±) exo-3-(3-Nitro-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane oxalate salt (E58) (±) exo -3-(3-Amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane (E52) (500mg, 2.79 mmol) was dissolved in 2N sulphuric acid (10ml) at 0 o C, and this solution was added to aqueous 2N sodium nitrite (5ml) at 0 o C. The mixture was then warmed to 45 o C for 30 min, basified using saturated aqueous potassium carbonate to pH 11, and extracted with chloroform. The organic phases were dried (Na₂SO₄), evaporated to dryness under reduced pressure and purified by elution through a plug of alumina in ether. The oxalate salt was crystallised from acetone to afford the title compound (E58) (0.43g, 1.44 mmoles, 51%) m.p. 151-153 o C. ¹H NMR (CD₃OD, 250MHz) δ: 1.9-2.05 (1H, m, 5-H), 2.2-2.4 (1H, m, 5-H), 3.27-3.63 (4H, m), 3.9-4.0 (3H, m), 5.13-5.24 (1H, m, 3H), 8.8 (1H, s, 5′H). Biological Activity Radio ligand Binding Cerebral cortex from Hooded Lister rats (Olac, UK) is homogenised in 2.5 vols ice-cold 50mM tris buffer pH 7.7 (at 25 o C). After centrifugation at 25,000 x g at 4 o C for 15 min the pellet is resuspended in 2.5 vols buffer and the wash repeated 3 times more. The final resuspension is in 2.5 volumes and the homogenates are stored in 1ml aliquots at -20 o C. Incubations (total volume 2ml) are prepared using the above buffer with the addition of 2mM magnesium chloride in the 3H-Oxotremorine-M (3H-OXO-M) experiments. For 3H-Quinuclidinyl Benzilate (3H-QNB), 1ml of stored membranes is diluted to 30ml and 0.1ml mixed with test compound and 0.27nM (c. 25,000 cpm) 3H-QNB (Amersham International). For 3H-OXO-M, 1ml of membranes is diluted to 6ml and 0.1ml mixed with test compound and 2nM (c. 250,000 cpm) 3H-OXO-M (New England Nuclear). Non-specific binding of 3H-QNB is defined using 1 µM Atropine sulphate (2µm Atropine) and of 3H-OXO-M using 10µM Oxotremorine. Non-specific binding values typically are 5% and 25% of total binding, respectively. Incubations are carried out at 37 o C for 30 min and the samples filtered using Whatman GF/B filters. (In the 3H-OXO-M experiments the filters are presoaked for 30 min in 0.05% polyethylenimine in water). Filters are washed with 3 x 4ml ice-cold buffer. Radioactivity is assessed using a Packard BPLD scintillation counter, 3ml Pico-Fluor 30 (Packard) as scintillant. This test provides an indication of the muscarinic binding activity of the test compound. The results are obtained as IC₅₀ values (i.e. the concentration which inhibits binding of the ligand by 50%) for the displacement of the muscarinic agonist 3H-OXO-M and the muscarinic antagonist 3H-QNB. The ratio IC₅₀(3H-QNB)/IC₅₀(3H-OXO-M) gives an indication of the agonist character of the compound. Agonists typically exhibit a large ratio; antagonists typically exhibit a ratio near to unity. The results are shown in Table 1:

Claims: A compound of formula (I) or a pharmaceutically acceptable salt thereof: in which one of X and Y represents hydrogen and the other represents Z, where Z is a group in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises zero, one or two nitrogen atoms, Q being optionally C-substituted by a group R₁ selected from halogen, CN, OR₂, SR₂, N(R₂)₂, NHCOR₂, NHCOOCH₃, NHCOOC₂H₅, NHOR₂, N₃, NHNH₂, NO₂, COR₂, COR₃, C₂₋₄ alkenyl, C₂₋₄ alkynyl, cyclopropyl or C₁₋₂ alkyl optionally substituted with OR₂, N(R₂)₂, SR₂, CO₂R₂, CON(R₂)₂ or one, two or three halogen atoms, in which each R₂ is independently hydrogen or C₁₋₂ alkyl and R₃ is OR₂, NH₂ or NHR₂; r represents an integer of 2 or 3, s represents an integer of 1 or 2 and t represents 0 or 1; R a and R b each represent hydrogen or, when X is hydrogen, optionally together represent a bond; with the proviso that when Y is hydrogen s is 1. A compound according to claim 1 wherein (r,s,t) is (2,2,0), (3,1,0), (2,1,0), (2,1,1) or (3,1,1). A compound according to claim 1 or 2 wherein Z represents 1,2-pyrazol-1-yl, 1,2,4-triazol-1-yl, 1,2,3-triazol-2-yl, tetrazol-1-yl or tetrazol-2-yl optionally C-substituted by R₁. A compound according to any preceding claim wherein R₁ is hydrogen, methyl, ethyl, amino, cyano, nitro, azido, chloro, bromo or iodo. A compound according to any preceding claim wherein R₁ is γ to the position of the azabicyclic ring on Z. A compound according to any preceding claim wherein R a and R b are both hydrogen. (±) 3-(3-Methylpyrazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(pyrazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(3-aminopyrazol-1-yl)-1-azabicyclo-[2.2.2]octane, (±) 3-(5-aminopyrazol-1-yl)-1-azabicyclo-[2.2.2]octane, 3-(3-methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]oct-2-ene, (±) 3-(3-methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) exo -3-(3-methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) 3-(5-methyltetrazol-2-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(5-aminotetrazol-2-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(4-methyl-1,2,3-triazol-2-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(4-methyl-1,2,3-triazol-3-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(4-methyl-1,2,3-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(tetrazol-2-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(tetrazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) exo -3-(5-aminotetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) exo -3-(5-aminotetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(tetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-methyltetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-methyltetrazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(tetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) exo -3-(5-ethyltetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-ethyltetrazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(4-methyl-1,2,3-triazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) endo -3-(5-aminotetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) 5-(1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(3-methyl-1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(tetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(tetrazol-1-yl)-azabicyclo[3.2.1]octane, (±) 5-(5-methyltetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(5-methyltetrazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) exo -3-(5-methyltetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-methyltetrazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(tetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) exo -3-(5-ethyltetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-ethyltetrazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(4-methyl-1,2,3-triazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) endo -3-(5-aminotetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) 5-(1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(3-methyl-1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(tetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(tetrazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(5-methyltetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(5-methyltetrazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(5-aminotetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(5-aminotetrazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 3-(1,2,3-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 5-(3-amino-1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(5-amino-1,2,4-triazol-1-yl)-1-azabicyclo[3.2.1]octane, (±) 3-(3-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(5-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 3-[5-bromotetrazol-2-yl]-1-azabicyclo[2.2.2]octane, (±) exo -3-(5-bromotetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-chlorotetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-iodotetrazol-2-yl)-1-azabicyclo[2.2.1]heptane, (±) 3-(5-chlocotetrazol-2-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(5-iodotetrazol-2-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(5-cyanotetrazol-2-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(3-bromo-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 3-(3-chloro-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.2]octane, (±) 5-(5-chlorotetrazol-2-yl)-1-azabicyclo[3.2.1]octane, (±) 5-(5-bromotetrazol-2-yl)-1-azabicyclo[3.2.1]octane, 4-(1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(3-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(3-chloro-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(3-bromo-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(5-amino-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, 4-(3-methyl-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane, (±) exo -3-(3-azido-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane or (±) exo -3-(3-nitro-1,2,4-triazol-1-yl)-1-azabicyclo[2.2.1]heptane or a pharmaceutically acceptable salt of any of the foregoing compounds. A process for the preparation of a compound of formula (I) as defined in claim 1 or a pharmaceutically acceptable salt thereof, which process comprises: (a) cyclising a compound of formula (II): in which (i) A represents Z or a group convertible thereto and B represents -(CH₂) j L₁ where L₁ is a leaving group or A and L₁ together represent -COO-; one of j, k and l is 1 and the other two independently represent an integer of 2 or 3, and R₅ represents hydrogen or an N-protecting group; to give a compound of formula (IIa): in which A′ represents Z or a group convertible thereto, x⁻ is an anion and the remaining variables are as previously defined; or (ii) A represents an electron withdrawing group, B represents hydrogen and R₅ represents -(CH₂) j L₂ where L₂ is a leaving group; one of k and l is 1 and the other and j independently represent an integer of 2 or 3; to give a compound of formula (IIb): in which K represents an electron withdrawing group or A′ and the remaining variables are as previously defined; and thereafter, optionally or as necessary and in any appropriate order, removing any R₅ N-protecting group, converting K to A′, converting A′ to Z, optionally interconverting Z and/or forming a pharmaceutically acceptable salt; or (b) cyclising a compound of formula (III): where R₅ is hydrogen or an N-protecting group, and either C is one, D is another and E is the remainder of -(CH₂) r -, -(CH₂) s - and -(CH₂) t -CR a A′-CHR b - or groups convertible thereto, A′ is Z or a group convertible thereto and L₃ is a leaving group; or C is one and E is the other of -(CH₂) r - and -(CH₂) s - or groups convertible thereto and D represents -(CH₂) t -CR a A′-CHR b - where A′ and L₃ together represent -COO-, and thereafter, optionally or as necessary and in any appropriate order, converting C, D and E to -(CH₂) r -, -(CH₂) s - and -(CH₂) t -CHR a A′-CHR b -, removing any R₅ protecting group, converting A′ to Z, optionally interconverting Z and/or forming a pharmaceutically acceptable salt; or (c) cyclising a compound of formula (IV): where F is one and G is the other of -(CH₂) r - and -(CH₂) s - or groups convertible thereto, and one of Y³ and Y⁴ is -(CH₂) u -K and the other is -(CH₂) v W or -(CH₂) v L₄ where K and W are electron withdrawing groups, L₄ is a leaving group, u is 1 or 2 and v is 0 or 1, with the provisos that, when Y⁴ is -(CH₂) v W, v is 1, and Y⁴ is not -(CH₂) v L₄, u and v being such that the desired compound of formula (I) is obtained, and thereafter, optionally or as necessary and in any appropriate order, hydrolysing and decarboxylating the cyclisation product and converting the carbonyl group to CHR a A′ where A′ is Z or a group convertible thereto, converting K to A′ as defined, converting A′ to Z, converting F and G to -(CH₂) r - and -(CH₂) s - as appropriate, interconverting Z and/or forming a pharmaceutically acceptable salt. A process for the preparation of a compound of formula (I) as defined in claim 1 or a pharmaceutically acceptable salt thereof, which process comprises reacting a compound of formula (IVa): in which R a , R b , r,s and t are as defined in formula (I), one of X′ and Y′ represents hydrogen and the other represents Z′ wherein Z′ is a group convertible to Z as defined in formula (I), to convert Z′ to Z and thereafter optionally forming a pharmaceutically acceptable salt. A compound of formula (IVb) or a salt thereof: in which R a , R b , r,s, and t are as defined in claim 1, one of X'' and Y'' represents hydrogen and the other represents Z'' where Z'' is hydrazino, azido or isocyano or R a and Z'' together are a hydrazone group, excluding 3-quinuclidinyl-hydrazine dihydrochloride 3-Quinuclidinyl-hydrazone, (±) 3-quinuclidinyl-hydrazine (±) exo and endo (1-azabicyclo[2.2.1]heptan-3-yl)hydrazine, (±) 1-azabicyclo[3.2.1]oct-5-ylhydrazine or (±) 3-azido-1-azabicyclo[2.2.2]octane. A pharmaceutical composition which comprises a compound according to claim 1 and a pharmaceutically acceptable carrier. A compound according to claim 1 for use as an active therapeutic substance. A compound according to claim 1 for use in the treatment and/or prophylaxis of dementia. Use of a compound according to claim 1 for the preparation of a medicament for the treatment and/or prophylaxis of dementia.

Inventors: BROMIDGE STEVEN MARK, JENKINS SARAH MARGARET, ORLEK SIDNEY BARRY, WADSWORTH HARRY JOHN, BROMIDGE, STEVEN MARK, JENKINS, SARAH MARGARET, ORLEK, SIDNEY BARRY, WADSWORTH, HARRY JOHN, BROMIDGE, STEVEN MARK, SMITHKLINE BEECHAM PHARM., JENKINS, SARAH MARGARET, SMITHKLINE BEECHAM PHARM., ORLEK, SIDNEY BARRY, SMITHKLINE BEECHAM PHARM., WADSWORTH, HARRY JOHN, SMITHKLINE BEECHAM PHARM.
Applicants: BEECHAM GROUP PLC
Application year: 1990
Main classification: C07D453
IPC codes: A61P25, C07D453, C07D487, A61K31, C07D471