Pantothenic acid derivatives

Abstract: Compounds represented by general formula (I) below wherein R¹ and R², which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R³ represents a saturated or unsaturated, linear, branched or cyclic, monovalent C₅∼C₂₅-aliphatic hydrocarbon group which may be substituted with an aro­ matic group, or a group of formula where R⁴ represents a saturated or unsaturated, linear, branched or cyclic, monovalent C₅∼C₂₅-­ aliphatic hydrocarbon group which may be sub­ stituted with an aromatic group, and R⁵ represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrocarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula -X¹-A-Y¹-, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C₂∼C₁₆-­ aliphatic hydrocarbon group which may be sub­ stituted with an aromatic group, a divalent aromatic hydrocarbon group or a divalent aro­ matic heterocyclic group; one of X¹ and Y¹ represents and the other represents -O-, -S- or in which R⁶ and R⁷ each represent a hydrogen atom or a lower alkyl group; (b) a group of formula -X²-(CH₂) ℓ -Y²-, where one of X² and Y² represents a group of formula and the other represents -O-, -S- or represents a 4∼7-­ membered, divalent nitrogen-containing aromatic heterocyclic group, and R⁶ has the same meaning as defined above, and ℓ is 0, 1 or 2; or (c) a group of formula where m is 2 or 3; n is an integer of from 1 to 4. The compounds have excellent inhibitory activ­ ity against acyl Co A-cholesterol-acyltransferase.

Description: The present invention relates to pantothenic acid derivatives which have excellent inhibitory activity against acyl CoA-cholesterol-acyltransferase (hereafter, abbreviated as ("ACAT"). Recently, it revealed that in artherosclerosis, a popular artheriosclerosis, lipophagy in which fat is accumulated is abserved to begin at the earliest stage of artheriosclerotic crisis. Main component of the fat accumulated is cholesterols. Further, many pathohistological and biochemical investigations revealed that the cholesterols are derived from plasma lipid. On the other hand, various epidemic researches showed that hyperlipemia is a major critical factor of artheriosclerotic diseases particularly premature coronary heart disease. Therefore, therapy of hyperlipemia is increasingly important in order to alleviate risks of arteriosclerotic diseases. As for remedies for the therapy of the diseases, development of a drug is strongly desired which can not only decrease level of serum lipid but also improve serum lipid balance or positively prevent crisis of artheriosclerosis. Many drugs have already been provided as hypolipidemics which exhibit clinical effects to some extent relative to decrease of total serum cholesterol. However, they are insufficient in the effect of decreasing mortality due to artheriosclerotic diseases. Recently, based on elucidation of lipid metabolism, there have been developed drugs which can control serum lipid balance, that is, drugs which are effective for increasing serum high density lipoprotein (HDL) level and decreasing serum low density lipoprotein (LDL) level, drugs which can inhibit biosynthesis of cholesterol and as a result decrease serum lipid level (HMG CoA reductase inhibitors) and the like. While they are effective for improving blood lipid level, these drugs have almost no effect on the control of absorption of alimentary cholesterol through intestinal walls. In addition, they have no activity for positively prevent crisis or development of artheriosclerosis; it requires further investigation to find whether they can alleviate risks of artheriosclerotic diseases or not. On the other hand, ACAT known as an intramembranous enzyme is present mostly in intracellular microsomes in liver and small intestines and catalyze the intracellular esterification of cholesterol. At present, it is known that there are two isozymes for this enzyme. The structures, physiological roles and the like of the ACAT have not been clarified yet because the isolation and purification of the enzyme are difficult. However, in view of the fact that it is known that ACAT play erucial role in the absorption of cholesterols through intestinal walls and accumulation of cholesterols within cells in a form of cholesterol esters and that the activity of the enzyme is increased in artheriosclerotic lesions. Thus, inhibition of intestinal ACAT would be expected to lead to decrease cholesterol esterification resulting in diminished intestinal absorption. Additional reduction in intracellular accumulation of cholesterol esters might be expected. Therefore, ACAT inhibitors offer potential for exhibiting both hypocholesterolemia and antiartheriosclerotic activity. FR-A-1 228 806 discloses pantothenic acid derivatives indicated by the following general formula (I) wherein Q = -X¹-A-Y¹- X1 = -NH- Y1 = -S- A = -CH₂-CH₂- As a result of extensive investigations with view to synthesizing substances which have excellent ACAT inhibitory activities, the present invention has been completed. Accordingly, the present invention provides a compound represented by general formula (I) below wherein R¹ and R², which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R³ represents a saturated or unsaturated, linear, branched or cyclic, monovalent C₅∼C₂₅-aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula where R⁴ represents a saturated or unsaturated, linear, branched or cyclic, monovalent C₅∼C₂₅-aliphatic hydrocarbon group which may be substituted with an aromatic group, and R⁵ represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrocarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula -X¹-A-Y¹-, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C₂∼C₁₆-aliphatic hydrocarbon group which may be substituted with an aromatic group, a divalent aromatic hydrocarbon group or a divalent aromatic heterocyclic group; one of X¹ and Y¹ represents and the other represents -O-, -S- or in which R⁶ and R⁷ each represent a hydrogen atom or a lower alkyl group; (b) a group of formula -X²-(CH₂) ℓ -Y²-, where one of X² and Y² represents a group of formula and the other represents -O-, -S- or in which represents a 4∼7-membered, divalent nitrogen-containing non-aromatic heterocyclic group, and R⁶ has the same meaning as defined above, and ℓ is 0, 1 or 2; or (c) a group of formula where m is 2 or 3; n is an integer of from 1 to 4, provided that if Q represents the group of formula -X¹-A-Y¹-, X¹ represents and A is -CH₂-CH₂-, then Y¹ cannot represent -S-. The term "lower" used herein indicates that elemental groups or compounds referred to together with this term have no more than 6 carbon atoms, preferably no more than 4 carbon atoms. The term "a protective group of a hydroxyl group" used herein refers to any protective groups for hydroxyl groups usually used which can easily release as a result of usual protecting group elimination reaction, for example, hydrolysis or hydrogenolysis. Specific examples of the protective group for a hydroxyl group include the following groups: substituted or unsubstituted alkyl or alkenyl groups such as methyl, methoxyethyl, methylthiomethyl, benzyloxymethyl, t-butoxymethyl, 2-methoxyethoxymethyl, 2,2,2-trichloroethoxymethyl, bis(2-chloroethoxy)methyl, 1-ethoxyethyl, 1-methyl-1-methoxyethyl, 1-(isopropoxy)ethyl, 2,2,2-trichloroethyl, t-butyl, allyl, cinnamyl, benzyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, p-chlorobenzyl, o-chlorobenzyl, p-cyanobenzyl, diphenylmethyl,α-naphthyldiphenylmethyl, triphenylmethyl, and di(p-methoxyphenyl)methyl groups; heterocyclic groups such as tetrahydropyranyl, tetrahydrothiopyranyl, 4-methoxytetrahydropyranyl, 4-methoxytetrahydrothiopyranyl, tetrahydrofuranyl and tetrahydrothiofuranyl; substituted silyl groups such as trimethylsilyl, triethylsilyl, isopropyldimethylsilyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, methyldiisopropylsilyl, methyldi-t-butylsilyl, tribenzylsilyl, triphenylsilyl, and triisopropylsilyl groups; acyl groups such as formyl, acetyl, propionyl, chloroacetyl, dichloroacetyl, trichloroacetyl, trifluoroacetyl, methoxyacetyl, triphenylmethoxyacetyl, phenoxyacetyl, p-chlorophenoxyacetyl, 2,6-dichloro-4-methylphenoxyacetyl, phenylacetyl, chlorodiphenylacetyl, 3-phenylpropionyl, 3-benzoylpropionyl, isobutyroyl, monosuccinoyl, 4-oxopentanoyl, pivaloyl, 2-butenoyl, (E)-2-methyl-2-butenoyl, benzoyl, 2-chlorobenzoyl, 3-nitrobenzoyl, 2-fluorobenzoyl, 3-trifluorobenzoyl, 3-trichlorobenzoyl, 4-phenylbenzoyl, 2,4,6-trimethylbenzoyl, and α-naphthoyl groups; substituted oxycarbonyl groups such as methoxycarbonyl, ethoxycarbonyl, 2,2,2-triethoxycarbonyl, isobutoxycarbonyl, vinyloxycarbonyl, aryloxycarbonyl, cinnamyloxycarbonyl, p-nitrophenoxycarbonyl, benzyloxycarbonyl, p-methoxybenzyloxycarbonyl, 3,4-dimethoxybenzyloxycarbonyl, and p-nitrobenzyloxycarbonyl groups; substituted carbamoyl groups such as phenylcarbamoyl, naphthylcarbamoyl, toluylcarbamoyl, fluorophenylcarbamoyl, difluorophenylcarbamoyl, nitrophenylcarbamoyl, cyanophenylcarbamoyl, benzylcarbamoyl, methylcarbamoyl, ethylcarbamoyl, isopropylcarbamoyl, butylcarbamoyl, cyclohexylcarbamoyl, cyclopropylmethylcarbamoyl, phenylthiocarbamoyl, naphthylthiocarbamoyl, toluylthiocarbamoyl, fluorophenylthiocarbamoyl, difluorophenylthiocarbamoyl, nitrophenylthiocarbamoyl, cyanophenylthiocarbamoyl, benzylthiocarbamoyl, propylthiocarbamoyl, butylthiocarbamoyl groups. In the case where R¹ and R² in formula (I) above each represent a protective group, R¹ and R² may combine to form an ylidene group such as methylene, ethylidene, 1-t-butylethylidene, 1-phenylethylidene, 2,2,2-trichloroethylidene, isopropylidene, butylidene, cyclopentylidene, cyclohexylidene, cyclobutylidene, benzylidene, p-methoxybenzylidene, 2,4-dimethoxybenzylidene, p-dimethylaminobenzylidene, o-nitrobenzylidene, methoxymethylene, ethoxymethylene, dimethoxymethylene, 1-methoxyethylidene, 1,2-dimethoxyethylidene,α-methoxybenzylidene groups. In formula (I) above, preferably R¹ and R², which are the same or different, each represent a hydrogen atom; a lower alkyl group, particularly a t-butyl gourp; a benzyl group which may optionally be substituted with a halogen atom, a lower alkoxy group, a nitro group or a cyano group, particularly, benzyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, p-chlorobenzyl, o-chlorobenzyl, p-cyanobenzyl group; a 5- or 6-membered saturated heterocyclic group containing as hetero atoms N, S or O selected from tetrahydropyranyl, tetrahydrothiopyranyl, 4-methoxytetrahydropyranyl, 4-methoxytetrahydrothiopyranyl, tetrahydrofuranyl and tetrahydrothiofuranyl groups; or an acyl group, particularly acetyl, propionyl, phenylacetyl, chlorodiphenylacetyl, 3-phenylpropionyl, 3-benzoylpropionyl, isobutyroyl, pivaloyl, 2-butenoyl, (E)-2-methyl-2-butenoyl, benzoyl, 2-chlorobenzoyl, 3-nitrobenzoyl, 2-fluorobenzyoyl, 3-trifuluoromethylbenzoyl, 3-trichloromethylbenzoyl, 4-phenylbenzoyl, 2,4,6-trimethylbenzoyl, and α-naphthoyl groups; or R¹ and R² may combine to form a ylidene group selected from 1-t-butylethylidene, 1-phenylethylidene, isopropylidene, butylidene, cyclopentylidene, cyclohexylidene, cycloheptylidene, benzylidene, p-methoxybenzyilidene, 2,4-dimethoxybenzylidene, p-dimethylaminobenzylidene, and o-nitrobenzylidene groups. As for the "saturated or unsaturated, linear, branched or cyclic monovalent aliphatic hydrocarbon group", there can be cited, for example, the following groups: (1) an alkyl group, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, neopentyl, isopentyl, t-pentyl, 1-ethylpentyl, 1-isopropylpentyl, 1-t-butylpentyl, 2-ethylpentyl, 2-isopropylpentyl, 2-t-butylpentyl, 3-ethylpentyl, 3-isopropylpentyl, 3-t-butylpentyl, hexyl, 1-ethylhexyl, 1-isopropylhexyl, 1-t-butylhexyl, 2-ethylhexyl, 2-isopropylhexyl, 2-t-butylhexyl, 3-ethylhexyl, 3-isopropylhexyl, 3-t-butylhexyl, heptyl, 1-ethylheptyl, 1-isopropylheptyl, 1-neopentylheptyl, 2-ethylheptyl, 2-isopropylheptyl, 2-neopentylheptyl, 3-ethylheptyl, 3-isopropylheptyl, 3-neopentylheptyl, octyl, 1-ethyloctyl, 1-isopropyloctyl, 1-t-butyloctyl, 2-ethyloctyl, 3-isopropyloctyl, 4-t-butyloctyl, nonyl, 1-methylnonyl, 1-ethylnonyl, 1-isopropylnonyl, 1-isobutylnonyl, 2-methylnonyl, 2-ethylnonyl, 3-isopropylnonyl, 4-isobutylnonyl, decyl, 1-ethyldecyl, 1,1-diethyldecyl, 1-t-butyldencyl, 3-ethyldecyl, 1,3-diethyldecyl, 2-t-butyldencyl, undecyl, 1-isopropylundecyl, 1,1-diethylundecyl, 2-isopropylundecyl, 1,2-diethylundecyl,dodecyl, 1-t-butyldodecyl, 1-isopropyldodecyl, 1,1-diethyldodecyl, 2-t-butyldodecyl, 3-isopropyldodecyl, 2,4-diethyldodecyl, tridecyl, 1,1-diethyltridecyl, 1-t butyltridecyl, 1,5-diethyltridecyl, 3-t-butyltridecyl, tetradecyl, 1-isobutyltetradecyl, pentadecyl, 1-methylpentadecyl, 1,1-dimethylpentadecyl, 1-ethylpentadecyl, 1,1-diethylpentadecyl, 1-isopropylpentadecyl, 1-t-butylpentadecyl, 2-isobutyltetradecyl, 3-methylpentadecyl, 2,6-dimethylpentadecyl, 2-ethylpentadecyl, 1,4-diethylpentadecyl, 3-isopropylpentadecyl, 2-t-butylpentadecyl, hexadecyl, 1,1-dimethylhexadecyl, 1-methylhexadecyl, 1-ethylhexadecyl, 1-isopropylhexadecyl, 1-t-butylhexadecyl, 1,3-dimethylhexadecyl, 2-methylhexadecyl, 4-ethylhexadecyl, 3-isopropylhexadecyl, 4-t-butylhexadecyl, heptadecyl, 1-methylheptadecyl, 1,1-dimethylheptadecyl, 1-ethylheptadecyl, 1-isopropylheptadecyl, 1-t-butylheptadecyl, 2-methylheptadecyl, 3,5-dimethylheptadecyl, 2-ethylheptadecyl, 5-isopropylheptadecyl, 3-t-butyheptadecyl, octadecyl, 1-methyloctadecyl, 1,1-dimethyloctadecyl, 2,3-dimethyloctadecyl, 5-ethyloctadecyl, 1,2-diethyloctadecyl, nonadecyl, 1-methylnonadecyl, 1,1-dimethylnonadecyl, 1-t-butylnonadecyl, 2-methylnonadecyl, 2,3-dimethylnonadecyl, 3-t-butylnonadecyl, eicosyl, 1-methyleicosyl, 1,1-dimethyleicosyl, 1-ethyleicosyl, 1-t-butyleicosyl, 4-methyleicosyl, 2,2-dimethyleicosyl, 3-ethyleicosyl, 2,2-dimethyleicosyl, 3-ethyleicosyl, and 2-t-butyleicosyl groups; (2) an alkenyl group, for example, vinyl, 1-propenyl, 1-methyl-2-propenyl, 1-methyl-1-butenyl, 2-butenyl, 1-methyl-3-butenyl, 1-pentenyl, 1-methyl-2-pentenyl, 1-ethyl-3-pentenyl, 4-pentenyl, 1,3-pentadienyl, 2,4-pentadienyl, 1-hexenyl, 1-methyl-2-hexenyl, 3-hexenyl, 4-hexenyl, 1-butyl-5-hexenyl, 1,3-hexadienyl, 2,4-haxedienyl, 1-heptenyl, 2-heptenyl, 3-heptenyl, 4-heptenyl, 5-heptenyl, 6-heptenyl, 1,3-heptadienyl, 2,4-heptadienyl, 1-octenyl, 2-octenyl, 3-octenyl, 4-octenyl, 5-octenyl, 6-octenyl, 7-octenyl, 1-nonenyl, 2-nonenyl, 3-nonenyl, 4-nonenyl, 5-nonenyl, 6-nonenyl, 7-nonenyl, 8-nonenyl, 9-decenyl, 1-methyl-9-decenyl, 1,1-dimethyl-9-decenyl, 1-ethyl-9-decenyl, 6-undecenyl, 1-methyl-6-undecenyl, 1,1-dimethyl 6-undecenyl, 6-tridecenyl, 1-methyl-6-tridecenyl, 1,1-dimethyl-6-tridecenyl, 8-tridecenyl, 1-methyl-8-tridecenyl, 1,1-dimethyl-8-tridecenyl, 10-tridecenyl, 1-methyl-10-tridecenyl, 1,1-dimethyl-10-tridecenyl, 10-pentadecenyl, 1-methyl-10-pentadecenyl, 1,1-dimethyl-10-pentadecenyl, 8-pentadecenyl, 1-methyl-8-pentadecenyl, 1,1-dimethyl-8-pentadecenyl, 12-heptadecenyl, 1-methyl-12-heptadecenyl, 1,1-dimethyl-12-heptadecenyl, 10-heptadecenyl, 1-methyl1-heptadecenyl, 1,1-dimethyl-10-heptadecenyl, 8-heptadecenyl, 1-methyl-8-heptadecenyl, 1,1-dimethyl-8-heptadecenyl, 1-ethyl-8-heptadecenyl, 8,11-heptadecadienyl, 1-methyl-8,11-heptadecadienyl, and 8,11,14-heptadecatrienyl groups. (3) an alkynyl group, for example, propargyl, 2-butynyl, 1-methyl-3-butynyl, 2-pentynyl, 1-ethyl-3-pentynyl, 1-isopropyl-4-pentynyl, 1,3-pentadiynyl, 2,4-pentadiynyl, 1-hexylnyl, 1-methyl-2-hexynyl, 2-methyl-3-hexynyl, 1-ethyl-4-hexynyl, 5-hexynyl, 1,3-hexadiynyl, 2,4-hexadiynyl, 1-heptynyl, 1-methyl-2-heptynyl, 3-heptynyl, 1-ethyl-4-heptynyl, 2-propyl-5-heptynyl, 2-ethyl-6-heptynyl, 1,3 heptadiynyl, 2,4-heptadiynyl, 1-octynyl, 1-methyl-2-octynyl, 3-methyl-1-octynyl, 4-methyl-1-octynyl, 1-methyl-5-octynyl, 6-methyl-1-octynyl, 7-octynyl, 1-nonynyl, 2-methyl-1-nonynyl, 3-methyl-1-nonynyl, 1-methyl-4-nonynyl, 5-nonynyl, 6-methyl-1-nonynyl, 1-methyl-7-nonynyl, 8-nonynyl, 9-decynyl, 1-methyl-9-decynyl, 1,1-dimethyl-9-decynyl, 1-ethyl-9-decynyl, 6-undecynyl, 1-methyl-6-undecynyl, 6-tridecynyl, 1-methyl-6-tridecynyl, 1,1-dimethyl-6-tridecynyl, 8-tridecynyl, 1-methyl-8-tridecynyl, 1,1-dimethyl-8-tridecynyl, 10-tridecynyl, 1-methyl-10-tridecynyl, 1,1-dimethyl-10-tridecynyl, 10-pentadecynyl, 1-methyl-10-pentadecynyl, 1,1-dimethyl-10-entadecynyl, 8-pentadecynyl, 1-methyl-8-pentadecynyl, 1,1-dimethyl-8-pentadecynyl, 12-hetadecynyl, 1-methyl-12-heptadecynyl, 1,1-dimethyl-12-heptadecynyl, 10-heptadecynyl, 1-methyl-10-heptadecynyl, 1,1-dimethyl-10-heptadecynyl, 8-heptadecynyl, 1-methyl-8-heptadecynyl, 1,1-dimethyl-8-heptadecynyl, 1-ethyl-8-heptadecynyl, 8,11-heptadecadiynyl, 1-methyl-8,11-heptadecadiynyl, 1-methyl-8,11-heptadecadiynyl, and 8,11,14-heptadecatriynyl groups; (4) a cycloalkyl group, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and perhydronaphthyl groups; (5) a cycloalkenyl group, for example, cyclopentenyl, cyclohexenyl, cycloheptenyl, cyclooctenyl, cyclopentadienyl, cyclohexadienyl, cycloheptadienyl, and cyclooctadienyl groups; (6) a cycloalkylalkyl group, for example, cyclohexylmethyl, cyclopentylmethyl, (4-isopropylcyclohexyl)methyl, (4-t-butylcyclohexyl)methyl, (4-neopentylcyclohexyl)methyl, 2-cyclopentylethyl, 2-cyclohexylethyl, 3-cyclopentylpropyl, 3-cyclohexylpropyl, 1-cyclopentylpentyl, 1-cyclohexylpentyl, 1-cyclohexylmethylpentyl, 3-cyclopentylpentyl, 2-cyclohexylpentyl, 2-cyclohexylmethylpentyl, 1-(4-t-butylcyclohexyl)methylpentyl, 1-cyclopentylhexyl, 1-cyclohexylhexyl, 1-cyclopentylmethylhexyl, 2-cyclopentylhexyl, 2-cyclohexylhexyl, 3-cyclopentylmethylhexyl, 1-(4-neopentylcyclohexyl)methylhexyl, 1-cyclopentylheptyl, 1-cyclohexylmethylheptyl, 1-(4-isopropylcyclohexyl)methylheptyl, 3-cyclopentylheptyl, 2-cyclohexylmethylheptyl, 4-(4-isopropylcyclohexyl)methylheptyl, 1-cyclopentyloctyl, 1-cyclohexyloctyl, 1-cyclopentylmethyloctyl, 2-cyclopentyloctyl, 3-cyclohexyloctyl, 2-cyclopentylmethyloctyl, 1-cyclopentylnonyl, 1-cyclohexylnonyl, 1-cyclohexylmethylnonyl, 3-cyclopentylnonyl, 2-cyclohexylnonyl, 2-cyclohexylmethylnonyl, 1-cyclopentyldencyl, 1-cyclopentylundecyl, 1-cyclohexylundecyl, 1-cyclopentyldodecyl, 1-cyclopentyltridecyl, 2-cyclopentyldecyl, 3-cyclopentylundecyl, 3-cyclohexylundecyl, 2-cyclopentyldodecyl, 2-cyclopentyltridecyl, 1-cyclopentyltetradecyl, 1-cyclohexyltetradecyl, 2-cyclopentyltetradecyl, and 3-cyclohexyltetradecyl groups; (7) a cycloalkenylalkyl group, for example, 2-cyclohexen-1-ylmethyl, 1-cyclopenten-1-ylmethyl, 2-(2-cyclopenten-1-yl)ethyl, 2-(1-cyclohexen-1-yl)ethyl, 3-(1-cyclopenten-1-yl)propyl, 3-(1-cyclohexen-1-yl)propyl, 4-(1-cyclohexen-1-yl)butyl, 1-(1-cyclopenten-1-yl)pentyl, 1-(1-cyclohexen-1-yl)pentyl, 5-(1-cyclohexen-1-yl)pentyl, 1-(1-cyclohexen-1-ylmethyl)pentyl, 1-(1-cyclopenten-1-yl)hexyl, 6-(1-cyclopenten-1-yl)hexyl, 1-(1-cyclohexen-1-yl)hexyl, 6-(1-cyclohexen-1-yl)hexyl, 1-(2-cyclopenten-1-ylmethyl)hexyl, 1-(1-cyclopenten-1-yl)heptyl, 7-(1-cyclopenten-1-yl)heptyl, 1-(1-cyclohexen-1-ylmethyl)heptyl, 1-(1-cyclopenten-1-yl)octyl, 1-(2-cyclopenten-1-yl)octyl, 1-(2-cyclopenten-1-yl)octyl, 1-(2-cyclohexen-1-yl)octyl, 8-(2-cyclohexen-1-yl)octyl, 1-(1-cyclopenten-1-ylmethyl)octyl, 1-(1-cyclopenten-1-yl)nonyl, 9-(1-cyclopenten-1-yl)nonyl, 1-(1-cyclohexen-1-yl)nonyl, 9-(1-cyclohexen-1-yl)nonyl, 1-(1-cyclohexen-1-ylmethyl)nonyl, 1-(1-cyclopenten-1-yl)decyl, 10-(1-cyclopenten-1-yl)decyl, 1-(2-cyclopenten-1-yl)undecyl, 1-(2-cyclohexen-1-yl)undecyl, 1-(1-cyclopenten-1-yl)dodecyl, 1-(1-cyclopenten-1-yl)tridecyl, 1-(2-cyclopenten-1-yl)tetradecyl, and 1-(3-cyclohexen-1-yl)tetradecyl groups; (8) an alkylcycloalkyl group and an alkenylcycloalkyl group, for example, 1-methylcyclobutyl, 2-ethylcyclobutyl, 2-propylcyclobutyl, 1-butylcyclobutyl, 1-pentylcyclobutyl, 1-hexylcyclobutyl, 1-heptylcyclobutyl, 1-octylcyclobutyl, 1-nonylcyclobutyl, 2-pentylcyclobutyl, 2-hexylcyclobutyl, 2-heptylcyclobutyl, 2-octylcyclobutyl, 2-nonylcyclobutyl, 1-decylcyclobutyl, 1-undecylcyclobutyl, 1-dodecylcyclobutyl, 1-pentadecylcyclobutyl, 1-(9-octadecynyl)cyclobutyl, 1-methylcyclopentyl, 2-methylcyclopentyl, 1-ethylcyclopentyl, 1-propylcyclopentyl, 1-butylcyclopentyl, 2-butylcyclopentyl, 1-pentylcyclopentyl, 1-hexylcyclopentyl, 3-hexylcyclopentyl, 1-heptylcyclopentyl, 1-octylcyclopentyl, 2-octylcyclopentyl, 1-decylcyclopentyl, 1-dodecylcyclopentyl, 1-tridecylcyclopentyl, 1-tetradecylcyclopentyl, 1-(9-octadecenyl)cyclopentyl, 1-methylcyclohexyl, 1-ethylcyclohexyl, 1-propylcyclohexyl, 2-methylcyclohexyl, 3-ethylcyclohexyl, 4-propylcyclohexyl, 1-butylcyclohexyl, 1-pentylcyclohexyl, 1-hexylcyclohexyl, 4-butylcyclohexyl, 4-pentylcyclohexyl, 4-hexylcyclohexyl, 1-heptylcyclohexyl, 1-octylcyclohexyl, 1-nonylcyclohexyl, 1-undecylcyclohexyl, 1-hexadecylcyclohexyl, and 1-(9-octadecenyl)cyclohexyl groups; (9) alkycycloalkenyl group and alkenylcycloalkyenyl group, for example, 1-methyl-2-cyclopentenyl, 1-ethyl-2-cyclopentenyl, 1-propyl-2-cyclopentenyl, 1-butyl-2-cyclopentenyl, 1-pentyl-2-cyclopentenyl, 1-hexyl-2-cyclopentenyl, 1-heptyl-2-cyclopentenyl, 1-octyl-2-cyclopentenyl, 2-methyl-2-cyclopentenyl, 3-ethyl-2-cyclopentenyl, 2-propyl-3-cyclopentenyl, 3-butyl-2-cyclopentenyl, 2-pentyl-2-cyclopentenyl, 3-hexyl-3-cyclopentenyl, 2-heptyl-2-cyclopentenyl, 2-octyl-3-cyclopentenyl, 1-decyl-2-cyclopentenyl, 1-dodecyl-2-cyclopentenyl, 1-tridecyl-2-cyclopentenyl, 1-tetradecyl-2-cyclopentenyl, 1-(9-octadecenyl)-2-cyclopentenyl, 1-methyl-2-cyclopentenyl, 1-ethyl-2-cyclohexenyl, 1-propyl-2-cyclohexenyl, 1-butyl-2-cyclohexenyl, 1-pentyl-2-cyclohexenyl, 1-hexyl-2-cyclohexenyl, 1-heptyl-2-cyclohexenyl, 4-methyl-2-cyclohexenyl, 2-ethyl-2-cyclohexenyl, 3-propyl-2-cyclohexenyl, 4-butyl-3-cyclohexenyl, 3-pentyl-3-cyclohexenyl, 4-hexyl-3-cyclohexenyl, 4-heptyl-3-cyclohexenyl, 1-octyl-2-cyclohexenyl, 2-nonyl-2-cyclohexenyl, 1-undecyl-2-cyclohexenyl, 1-hexadecyl-2-cyclohexenyl, and 1-(9-octadecenyl-2-cyclohexenyl groups; and the like. The saturated or unsaturated, linear, branched or cyclic monovalent aliphatic hydrocarbon groups may optionally be substituted with an aromatic group selected from an aromatic hydrocarbon group and an aromatic heterocyclic group. Examples of the aromatic hydrocarbon group include phenyl and naphthyl groups. Examples of the aromatic heterocyclic group include furyl, thienyl, pyridyl, quinolyl, isoquinolyl, pyridazinyl, pyrazinyl, indolyl, benzoxadiazolyl, imidazolyl, benzothiadiazolyl, triazolyl and tetrazolyl groups. Furthermore, these aromatic groups may have one or more substituent groups. Specific examples of the substituent groups include a halogen atom such as chlorine, bromine and fluorine, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a cyano group, a nitro group, a trichloromethyl group, a trifluoromethyl group, a hydroxyl group, a phenyl group, a phenoxy group, and the like. As for the saturated or unsaturated, linear, branched or cyclic monovalent aliphatic hydrocarbon group which may be substituted with an aromatic group, represented by R³ and R⁴ in formula (I) above, those groups are used which are of a relatively long chain, i.e., have from 5 to 25 carbon atoms, preferably from 8 to 22 carbon atoms. On the other hand, the saturated or unsaturated, linear, branched or cyclic monovalent aliphatic hydrocarbon group which may be substituted with an aromatic group, represented by R⁵ in formula (I) above, may be of either short chain or long chain but generally those groups are preferred which are of a short chain, preferably having from 1 to 10 carbon atoms, more preferably from 1 to 8 carbon atoms. It is desirable that total carbon atom number of R⁴ and R⁵ is in a range of from 5 to 25, preferably form 8 to 22. Specific examples of the group of formula include monosubstituted amino groups such as 2-cyclopentylethyl-amino, 2-cyclohexylethylamino, 3-cyclopentylpropylamino, 3-cyclohexylpropylamino, 2-cyclopentyl-1-methylethylamino, 2-cyclopentyl-1,1-dimethylethylamino, 2-cyclohexyl-1-methylethylamino, 3-cyclopentylpropylamino, 3 cyclohexylpropylamino, 4-cyclohexyl-1,1-dimethylbutylamino, 1-methylpentylamino, 1,1-dimethylpentylamino, 1-ethylpentylamino, 1-cyclohexyl-4-methylpentylamino, 1-cyclopentyl-4-methylpentylamino, 2-methylpentylamino, 1,2-dimethylpentylamino, 2-ethylpentylaminio, 2-cyclohexyl-4-methylpentylamino, 2-cyclopentyl-4-methylpentylamino, 3-methylpentylamino, 1,3-dimethylpentylamino, 3-ethylpentylamino, 1-cyclohexyl-3-methylpentylamino, 1-cyclopentyl-3-methylpentylamino, hexylamino, 1-methylhexylamino, 1,1-dimethylhexylamino, 1-ethylhexylamino, 1,1-diethylhexylamino, 1-propylhexylamino, 1-butylhexylamino, 1-cyclopentylhexylamino, 2-methylhexylamino, 1,2-dimethylhexylamino, 2-ethylhexylamino, 1,2-diethylhexylamino, 2-propylhexylamino, 2-butylhexylamino, 6-cyclopentylhexylamino, 6-cyclohexylhexylamino, heptylamino, 1-ethylheptylamino, 1,1-dimethylheptylamino, 1-cyclohexylheptylamino, 1-cyclopentylheptylamino, 1-cyclohexylmethylheptylamino, 1-cyclopentylmethylheptylamino, octylamino, 1,1-dimethyloctylamino, 1-methyloctylamino, 1-ethyloctylamino, 1,1-diethyloctylamino, 1-propyloctylamino, 1-butyloctylamino, 1-cyclopentyloctylamino, 1-cyclohexyloctylamino, 1-cyclopentylmethyloctylamino, 1-cyclohexylmethyloctylamino, nonylamino, 1-methylnonylamino, 1,1-dimethylnonylamino, 1-ethylnonylamino, 1,1-diethylnonylamino, decylamino, 1-methyldecylamino, 1,1-dimethyldecylamino, 1-ethyldecylamino, 1,1-diethyldecylamino, 1-cyclopentyldecylamino, 1-cyclohexyldecylamino, 1-cyclopentylmethyldecylamino, 1-cyclohexylmethyldecylamino, undecylamino, 1-methylundecylamino, 1,1-dimethylundecylamino, dodecylamino, 1-methyldodecylamino, 1,1-dimethyldodecylamino, tetradecylamino, 1-methyltetradecylamino, 1,1-dimethyltetradecylamino, pentadecylamino, 1-methylpentadecylamino, 1,1-dimethylpentadecylamino, hexadecylamino, 1-methylhexadecylamino, 1,1-dimethylhexadecylamino, heptadecylamino, 1-methylheptadecylamino, 1,1-dimethylheptadecylamino, octadecylamino, 1-methyloctadecylamino, 1,1-dimethyloctadecylamino, 3-cyclopentyl-2-propenylamino, 3-cyclohexyl-2-propenylamino, 1,1-dimethyl-3-butenylamino, 1-ethyl-3-butenylamino, 1-cyclopropyl-3-butenylamino, 1-methyl-2-pentenylamino, 1,1-dimethyl-2-pentenylamino, 1-ethyl-2-pentenylamino, 1-cyclopropyl-2-pentenylamino, 2-hexenylamino, 1-methyl-2-hexenylamino, 1,1-dimethyl-2-hexenyl-amino, 1,1-dimethyl-2-hexenylamino, 3-hexenylamino, 1-methyl-3-hexenylamino, 1,1-dimethyl-3-hexenylamino, 2-heptenylamino, 1-methyl-2-heptenylamino, 2-octenylamino, 1-methyl-2-octenylamino, 3-nonenylamino, 1-methyl-3-nonenylamino, 1,1-dimethyl-3-nonenylamino, 1-ethyl-3-nonenylamino, 1-propyl-3-nonenylamino, 8-nonenylamino, 1-methyl-8-nonenylamino, 1,1-dimethyl-8-nonenylamino, 1-ethyl-8-nonenylamino, 9-decenylamino, 1-methyl-9-decenylamino, 1,1-dimethyl-9-decenylamino, 1-ethyl-9-decenylamino, 6-undecenylamino, 1-methyl-6-undecenylamino, 1,1-dimethyl-6-undecenylamino, 6-tridecenylamino, 1-methyl-6-tridecenylamino, 1,1-dimethyl-6-tridecenylamino, 8-tridecenylamino, 1-methyl-8-tridecenylamino, 1,1-dimethyl-8-tridecenylamino, 10-tridecenylamino, 1-methyl-10-tridecenylamino, 1,1-dimethyl-10-tridecenylamino, 10-pentadecenylamino, 1-methyl-10-pentadecenylamino, 1,1-dimethyl-10-pentadecenylamino, 8-pentadecenylamino, 1-methyl-8-pentadecenylamino, 1,1-dimethyl-8-pentadecenylamino, 12-heptadecenylamino, 1,1-dimethyl-12-heptadecenylamino, 10-heptadecenylamino, 1-methyl-10-heptadecenylamino, 1,1-dimethyl-10-heptadecenylamino, 8-heptadecenylamino, 1-methyl-8-heptadecenylamino, 1,1-dimethyl-8-heptadecenylamino, 1-ethyl-8-heptadecenylamino, 8,11-heptadecadienylamino, 1-methyl-8,11-heptadecadienylamino, 8,11,14-heptadecatrienylamino, 1-ethylcyclobutylamino, 1-propylcyclobutylamino, 1-butylcyclobutylamino, 1-pentylcyclobutylamino, 1-hexylcyclobutylamino, 1-pentylcyclobutylamino, 1-octylcyclobutylamino, 1-nonylcyclobutylamino, 1-decylcyclobutylamino, 1-undecylcyclobutylamino, 1-dodecylcyclobutylamino, 1-pentadecylcyclobutylamino, 1-(9-octadecenyl)cyclobutylamino, 1-methylcyclopentylamino, 1-ethylcyclopentylamino, 1-butylcyclopentylamino, 1-hexylcyclopentylamino, 1-octylcyclopentylamino, 1-decylcyclopentylamino, 1-dodecylcyclopentylamino, 1-tridecylcyclopentylamino, 1-tetradecylcyclopentylamino, 1-(9-octadecenyl)cyclopentylamino, cyclohexylamino, 1-methylcyclohexylamino, 1-propylcyclohexylamino, 1-pentylcyclohexylamino, 1-heptylcyclohexylamino, 1-nonylcyclohexylamino, 1-undecylcyclohexylamino, 1-hexadecylcyclohexylamino, and 1-(9-octadecenyl)cyclohexylamino groups; disubstituted amino groups such as (2-cyclopentylethyl)ethylamino, (2-cyclopentylbutyl)ethylamino, (2-cyclopentylethyl)octylamino, (2-cyclohexylethyl)propylamino, (2-cyclohexylethyl)pentylamino, (2-cyclohexylethyl)decylamino, (3-cyclopentylpropyl)hexylamino, (3-cyclohexylpropyl)octylamino, (2-cyclopentyl-1-methylethyl)butylamino, (2-cyclopentyl-1,1-dimethylethyl)hexylamino, (2-cyclohexyl-1-methylethyl)decylamino, (3-cyclopentylpropyl)heptylamino, (3-cyclohexylpropyl)octylamino, (4-cyclohexyl-1,1-dimethylbutyl)pentylamino, hexyl(1-methylpentyl)amino, (1,1-dimethylpentyl)heptylamino, (1-ethylpentyl)decylamino, (1-cyclohexyl-4-methylpentyl)butylamino, (1-cyclopentyl-4-methylpentyl)pentylamino, (2-methylpentyl)decylamino, (1,2-dimethylpentyl)heptylamino, (2-ethylpentyl)dodecylamino, (2-cyclohexyl-4-methylpentyl)butylamino, (2-cyclopentyl-4-methylpentyl)propylamino, (3-methylpentyl)octylamino, (1,3-dimethylpentyl)heptylamino, (3-ethylpentyl)nonylamino, (1-cyclohexyl-3-methylpentyl)butylamino, (1-cyclopentyl-3-methylpentyl)propylamino, dihexylamino, butylhexylamino, hexyloctylamino, decylhexylamino, (1-methylhexyl)pentylamino, (1,1-dimethylhexyl)decylamino, (1-ethylhexyl)undecylamino, (1,1-diethylhexyl)octylamino, heptyl(1-propylhexyl)amino, (1-butylhexyl)propylamino, (1-cyclopentylhexyl)butylamino, (2-methylhexyl)octylamino, decyl(1,2-dimethylhexyl)amino, (2-ethylhexyl)tetradecylamino, (1,2-diethylhexyl)octylamino, (2-propylhexyl)dodecylamino, (2-butylhexyl)octylamino, (6-cyclopentylhexyl)butylamino, (6-cyclohexylhexyl)propylamino, diheptylamino, (1-ethylheptyl)tridecylamino, (1,1-dimethylheptyl)pentylamino, (1-cyclohexylheptyl)pentylamino, (1-cyclopentylheptyl)hexylamino, (1-cyclohexylmethylheptyl)butylamino, (1-cyclopentylmethylheptyl)propylamino, octylpropylamino, hexyloctylamino, (1,1-dimethyloctyl)pentylamino, hexyl(1-methyloctyl)amino, (1-ethyloctyl)pentylamino, (1,1-diethyloctyl)butylamino, octyl(1-propyloctyl)amino, (1-butyloctyl)hexylamino, (1-cyclopentyloctyl)pentylamino, (1-cyclohexyloctyl)butylamino, (1-cyclopentylmethyloctyl)propylamino, (1-cyclohexylmethyloctyl)propylamino, nonylpropylamino, (1-methylnonyl)heptylamino, (1,1-dimethylnonyl)hexylamino, (1-ethylnonyl)butylamino, (1,1-diethylnonyl)propylamino, hexyldecylamino, (1-methyldecyl)pentylamino, (1,1-dimethyldecyl)hexylamino, (1-ethyldecyl)butylamino, (1,1-diethyldecyl)pentylamino, (1-cyclopentyldecyl)butylamino, (1-cyclohexyldecyl)propylamino, (1-cyclopentylmethyldecyl)ethylamino, (1-cyclohexylmethyldecyl)methylamino, butylundecylamino, (1-methylundecyl)propylamino, (1,1-dimethylundecyl)propylamino, butyldodecylamino, (1-methyldodecyl)propylamino, (1,1-dimethyldodecyl)propylamino, propyltetradecylamino, (1-methyltetradecyl)butylamino, (1,1-dimethyltetradecyl)propylamino, butylpentadecylamino, (1-methylpentadecyl)butylamino, (1,1-dimethylpentadecyl)propylamino, ethylhexadecylamino, ethyl(1-methylhexadecyl)amino, (1,1-dimethylhexadecyl)methyamino, heptadecylamethylamino, (1-methylheptadecyl)methylamino, (1,1-dimethylheptadecyl)methylamino, methyloctadecylamino, ethyl(1-methyloctadecyl)amino, ethyl(1,1-dimethyloctadecyl)amino, (3-cyclopentyl-2-propenyl)hexylamino, (3-cyclohexyl-2-propenyl)heptylamino, (1,1-dimethyl-3-butenyl)octylamino, (1-ethyl-3-butenyl)nonylamino, (1-cyclopropyl-3-butenyl)decylamino, (1-methyl-2-pentenyl)decylamino, (1,1-dimethyl-2-pentenyl)nonylamino, (1-ethyl-2-pentenyl)decylamino, (1-cyclopropyl-2-pentenyl)heptylamino, (2-hexenyl)octylamino, (1-methyl-2-hexenyl)pentylamino, (1,1-dimethyl-2-hexenyl)decylamino, (3-hexenyl)butylamino, (1-methyl-3-hexenyl)octenylamino, (1,1-dimethyl-3-hexenyl)octenylamino, di(2-heptenyl)amino, (1-methyl-2-heptenyl)heptylamino, pentyl(2-octenyl)amino, (1-methyl-2-octenyl)hexylamino, heptyl(3-nonenyl)amino, (1-methyl-3-nonenyl)hexylamino, (1,1-dimethyl-3-nonenyl)hexylamino, (1-ethyl-3-nonenyl)pentylamino, butyl(1-propyl-3-nonenyl)amino, (8-nonenyl)pentylamino, (1-methyl-8-nonenyl)pentylamino, (1,1-dimethyl-8-nonenyl)butylamino, (1-ethyl-8-nonenyl)pentylamino, (9-decenyl)propylamino, (1-methyl-9-decenyl)pentylamino, (1,1-dimethyl-9-decenyl)butylamino, (1-ethyl-9-decenyl)propylamino, pentyl(6-undecenyl)amino, (1-methyl-6-undecenyl)butylamino, (1,1-dimethyl-6-undecenyl)propylamino, pentyl(6-tridecenyl)amino, (1-methyl-6-tridecenyl)pentylamino, (1,1-dimethyl-6-tridecenyl)ethylamino, butyl(8-tridecenyl)amino, butyl(1-methyl-8-tridecenyl)amino, (1,1-dimethyl-8-tridecenyl)ethylamino, ethyl(10-tridecenyl)amino, butyl(1-methyl-10-tridecenyl)amino, (1,1-dimethyl-10-tridecenyl)propylamino, butyl(10-pentadecenyl)amino, butyl(1-methyl-10-pentadecenyl)amino, (1,1-dimethyl-10-pentadecenyl)propylamino, (8-pentadecenyl)propylamino, (1-methyl-8-pentadecenyl)propylamino, ethyl(1,1-dimethyl-8-pentadecenyl)amino, butyl(12-heptadecenyl)amino, ethyl(1-methyl-12-heptadecenyl)amino, 1,1-dimethyl-12-heptadecenyl)propylamino, ethyl(10-heptadecenyl)amino, (1-methyl-10-heptadecenyl)propylamino, ethyl(1,1-dimethyl-10-heptadecenyl)amino, (8-heptadecenyl)methylamino, methyl(1-methyl-8-heptadecenyl)amino, ethyl(1,1-dimethyl-8-heptadecenyl)amino, (1-ethyl-8-heptadecenyl)propylamino, (8,11-heptadecadienyl)methylamino, methyl(1-methyl-8,11-heptadecadienyl)amino, methyl(8,11,14-heptadecatrienyl)amino, (1-ethylcyclobutyl)pentylamino, heptyl(1-propylcyclobutyl)amino, (1-butylcyclobutyl)hexylamino, butyl(1-pentylcyclobutyl)amino, (1-hexylcyclobutyl)heptylamino, propyl(1-pentylcyclobutyl)amino, ethyl(1-octylcyclobutyl)amino, propyl(1-nonylcyclobutyl)amino, ethyl(1-decylcyclobutyl)amino, methyl(1-undecylcyclobutyl)amino, (1-dodecylcyclobutyl)methylamino, ethyl(1-pentadecylcyclobutyl)amino, methyl[1-(9-octadecenyl)cyclobutyl]amino, methyl(1-methylcyclopentyl)amino, (1-ethylcyclopentyl)propylamino, propyl(1-propylcyclopentyl)amino, (1-butylcyclopentyl)pentylamino, (1-hexylcyclopentyl)methylamino, methyl(1-octyl-cyclopentyl)amino, (1-decylcyclopentyl)methylamino, (1-dodecylcyclopentyl)methylamino, methyl(1-tridecylcyclopentyl)amino, methyl(1-tetradecylcyclopentyl)amino, methyl[1-(9-octadecenyl)cyclopentyl]amino, cyclohexyloctylamino, heptyl(1-methylcyclohexyl)amino, hexyl(1-propylcyclohexyl)amino, hexyl(1-pentylcyclohexyl)amino, (1-heptylcyclohexyl)pentylamino, butyl(1-monylcyclohexyl)amino, ethyl(1-undecylcyclohexyl)amino, ethyl(1-hexadecylcyclohexyl)amino, methyl[1-(9-octadecenyl)cyclohexyl]amino, benzylhexylamino, benzylheptylamino, benzyloctylamino, benzyldecylamino, benzylnonylamino, benzylundecylamino, nonyl(2-phenylethyl)amino, nonyl(4-phenylbutyl)amino, 4-neopentylbenzylnonylamino, 4-isopropylbenzylnonylamino, and heptyl(4-neopentylbenzylamino) groups. R₃ in formula (I) above may preferably represent the following groups: (1) a C₅-C₂₅-alkyl group which is linear or has a branched chain at the 1-position thereof, particularly pentyl, 1-isopropylpentyl, 1-t-butylpentyl, hexyl, 1-isopropylhexyl, 1-t-butylhexyl, heptyl, 1-isopropylheptyl, 1-butylheptyl, octyl, 1-t-butyloctyl, nonyl, 1-isobutylnonyl, decyl, 1-ethyldecyl, 1,1-diethyldecyl, 1-t-butyldecyl, undecyl, 1-isopropylundecyl, 1,1-diethylundecyl, dodecyl, 1-t-butyldodecyl, 1-isopropyldodecyl, 1,1-diethyldodecyl, tridecyl, 1,1-diethyltridecyl, 1-t-butyltridecyl, tetradecyl, 1-isobutyltetradecyl, pentadecyl, 1-methylpentadecyl, 1,1-dimethylpentadecyl, 1-ethylpentadecyl, 1,1-diethylpentadecyl, 1-isopropylpentadecyl, 1-t-butylpentadecyl, hexadecyl, 1,1-dimethylhexadecyl, 1-methylhexadecyl, 1-ethylhexadecyl, 1-isopropylhexadecyl, 1-t-butylhexadecyl, heptadecyl, 1-methylheptadecyl, 1,1-dimethylheptadecyl, 1-ethylheptadecyl, 1-isopropylheptadecyl, 1-t-butylheptadecyl, octadecyl, 1-methyloctadecyl, 1,1-dimethyloctadecyl, 1-ethyloctadecyl, or 1,1-diethyloctadecyl group. (2) a C₁₂-C₁₈-alkenyl group which is linear or has a branched chain at the 1-position thereof, particularly 1,1-dimethyl-9-decenyl, 1-ethyl-9-decenyl, 1-methyl-6-undecenyl, 1,1-dimethyl-6-undecenyl, 6-tridecenyl, 1-methyl-6-tridecenyl, 1,1-dimethyl-6-tridecenyl, 8-tridecenyl, 1-methyl-8-tridecenyl, 1,1-dimethyl-8-tridecenyl, 10-tridecenyl, 1-methyl-10-tridecenyl, 1,1-dimethyl-10-tridecenyl, 10-pentadecenyl, 1-methyl-10-pentadecenyl, 1,1-dimethyl-10pentadecenyl, 8-pentadecenyl, 1-methyl-8-pentadecenyl, 1,1-dimethyl-8-pentadecenyl, 12-heptadecenyl, 1-methyl-12-heptadecenyl, 1,1-dimethyl-12-heptadecenyl, 10-heptadecenyl, 1-methyl-10-heptadecenyl, 1-methyl-10-heptadecenyl, 1,1-dimethyl-10-heptadecenyl, 8-heptadecenyl, 1-methyl-8-heptadecenyl, 1,1-methyl-8-heptadecenyl, 1-ethyl-8-heptadecenyl, 8,11-heptadecadienyl, 1-methyl-8,11-heptadecadienyl, or 8,11,14-heptadecadienyl group; (3) a C₈-C₁₈-alkyl-C₄-C₆-cycloalkyl group, particularly 1-octyl-cyclobutyl, 1-nonylcyclobutyl, 1-decylcyclobutyl, 1-undecylcyclobutyl, 1-dodecylcyclobutyl, 1-pentadecylcyclobutyl, 1-(9-octadecenyl)cyclobutyl, 1-octylcyclopentyl, 1-decylcyclopentyl, 1-dodecylcyclopentyl, 1-tridecylcyclopentyl, 1-tetradecylcyclopentyl, 1-(9-octadecenyl)cyclopentyl, 1-nonylcyclohexyl, 1-undecylcyclohexyl, or 1-(9-octadecenyl)cyclohexyl group; (4) a monosubstituted amino group substituted with a C₈-C₂₀-alkyl group or a C₈-C₂₀-alkenyl group, for example, 1-isopropylpentylamino, 1-t-butylpentylamino, 1-isopropylhexylamino, 1-t-butylhexylamino, 1-isopropylheptylamino, 1-t-butyloctylamino, 1-isobutylnonylamino, decylamino, 1-ethyldecylamino, 1,1-diethyldecylamino, 1-t-butyldecylamino, undecylamino, 1-isopropylundecylamino, 1,1-diethylundecylamino, dodecylamino, 1-t-butyldodecylamino, 1-isopropyldodecylamino, 1,1-diethyldodecylamino, tridecylamino, 1,1-diethyltridecylamino, 1-t-butyltridecylamino, tetradecylamino, 1-isobutyltetradecylamino, pentadecylamino, 1-methylpentadecylamino, 1,1-dimethylpentadecylamino, 1-ethylpentadecylamino, 1,1-diethylpentadecylamino, 1-isopropylpentadecylamino, 1-t-butylpentadecylamino, hexadecylamino, 1,1-dimethylhexadecylamino, 1-methylhexadecylamino, 1-ethylhexadecylamino, 1-isopropylhexadecylamino, 1-t-butylhexadecylamino, heptadecylamino, 1-methylheptadecylamino, 1,1-dimethylheptadecylamino, 1-ethylheptadecylamino, 1-isopropylheptadecylamino, 1-t-butylheptadecylamino, octadecylamino, 1-methyloctadecylamino, 1,1-dimethyloctadecylamino, 1-ethyloctadecylamino, 1,1-diethyloctadecylamino, 1,1-dimethyl-9-decenylamino, 1,1-methyl-6-undecenylamino, 1,1-dimethyl-6-undecenylamino, 1-methyl-6-tridecenylamino, 1,1-dimethyl-6-tridecenylamino, 8-tridecenylamino, 1-methyl-8-tridecenylamino, 1,1-dimethyltridecenylamino, 10-tridecenylamino, 1-methyl-10-tridecenylamino, 1,1-dimethyl-10-tridecenylamino, 10-pentadecenylamino, 1-methyl-10-pentadecenylamino, 1,1-dimethyl-10-pentadecenylamino, 8-pentadecenylamino, 1-methyl-8-pentadecenylamino, 1,1-dimethyl-8-pentadecenylamino, 12-heptadecenylamino, 1-methyl-12-heptadecenylamino, 1,1-dimethyl-12-heptadecenylamino, 10-heptadecenylamino, 1-methyl-10-heptadecenylamino, 1,1-dimethyl-10-heptadecenylamino, 8-heptadecenylamino, 1-methyl-8-heptadecenylamino, 1,1-dimethyl-8-heptadecenylamino, 1-ethyl-8-heptadecenylamino, 8,11-heptadecadienylamino, 1-methyl-8,11-heptadecadienylamino, 8,11-14-heptadecatrienylamino, 1-hexylcyclobutylamino, 1-heptylcyclobutylamino, 1-octylcyclobutylamino, 1-nonylcyclobutylamino, 1-decylcyclobutylamino, 1-undecylcyclobutylamino, 1-dodecylcyclobutylamino, 1-pentadecylcyclobutylamino, 1-(9-octadecenyl)cyclobutylamino, 1-pentylcyclopentylamino, 1-hexylcyclopentylamino, 1-heptylcyclopentylamino, 1-octylcyclopentylamino, 1-decylcyclopentylamino, 1-dodecylcyclopentylamino, 1-tridecylcyclopentylamino, 1-tetradecylcyclopentylamino, 1-(9-octadecenyl)cyclopentylamino, 1-nonylcyclohexylamino, 1-undecylcyclohexylamino, 1-hexadecylcyclohexylamino, or 1-(9-octadecenyl)cyclohexylamino; or (5) a disubstituted amino group disubstituted with an alkyl group or an alkenyl group and having total carbon atoms in a range of from 8 to 20, for example, decylhexylamino, octylpropylamino, hexyloctylamino, (1-butyloctyl)hexylamino, (1-ethyldecyl)butylamino, (1,1-diethyldecyl)pentylamino, butylundecylamino, butyldodecylamino, propyltetradecylamino, butylpentadecylamino, (1-methylpentadecyl)butylamino, (1,1-dimethylpentadecyl)propylamino, ethylhexadecylamino, ethyl(1-methylhexadecyl)amino, (1,1-dimethylhexadecyl)methylamino, heptadecylmethylamino, (1-methylheptadecyl)methylamino, (1,1-dimethylheptadecyl)methylamino, methyloctadecylamino, ethyl(1-methyloctadecyl)amino, ethyl(1,1-dimethyloctadecyl)amino, (1,1-dimethyl-9-decenyl)butylamino, (1-ethyl-9-decenyl)propylamino, pentyl(6-undecenyl)amino, (1-methyl-6-undecenyl)butylamino, (1,1-dimethyl-6-undecenyl)propylamino, pentyl(6-tridecenyl)amino, (1-methyl-6-tridecenyl)pentylamino, (1,1-dimethyl-6-tridecenyl)ethylamino, butyl(8-tridecenyl)amino, butyl(1-methyl-8-tridecenyl)amino, (1,1-dimethyl-8-tridecenyl)ethylamino, ethyl(10-tridecenyl)amino, butyl(1-methyl-10-tridecenyl)amino, (1,1-dimethyl-10-tridecenyl)propylamino, butyl(10-pentadecenyl)amino, butyl(1-methyl-10-pentadecenyl)amino, (1,1-dimethyl-10-pentadecenyl)propylamino, (8-pentadecenyl)propylamino, (1-methyl-8-pentadecenyl)propylamino, ethyl(1,1-methyl-8-pentadecenyl)propylamino, butyl(12-heptadecenyl)amino, ethyl(1-methyl-12-heptadecenyl)amino, (1,1-dimethyl-12-heptadecenyl)propylamino, ethyl(10-hepotadecenyl)amino, (1-methyl-10-heptadecenyl)propylamino, ethyl(1,1-dimethyl-10-heptadecenyl)amino, (8-heptadecenyl)methylamino, methyl(1-methyl-8-heptadecenyl)amino, ethyl(1,1-dimethyl-8-heptadecenyl)amino, (1-ethyl-8-heptadecenyl)propylamino, (8,11-heptadecadienyl)amino, or methyl(8,11,14-heptadecatrienyl)amino group. The specific examples exemplified in (1) to (5) above for the groups represented by R³ may be substituted with an aromatic group, for example, a phenyl group, a napthyl group, a furyl group, a thienyl group. The aromatic groups may further be substituted with a halogen atom, a lower alkyl group, a cyano group or the like. As for the "saturated or unsaturated, linear, branched or cyclic divalent aliphatic hydrocarbon group which may be substituted with an aromatic group", there can be cited, for example, the following groups: (1) alkylene groups or cycloalkylalkylene groups, for example, C₂-C₁₆-alkylene groups and C₅-C₇-cycloalkyl-C₂-C₁₀-alkylene groups such as ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, octamethylene, nonamethylene, decamethylene, propylene, ethylethylene, isopropylethylene, propylethylene, butylethylene, isobutylethylene, cyclopentylethylene, cyclohexylethylene, cycloheptylethylene, 1,1-dimethylethylene, 1-methyltrimethylene, 2-methyltrimethylene, 1-ethyltrimethylene, 1-isopropyltrimethylene, 1-isobutyltrimethylene, 1-cyclopentyltrimethylene, 1-cyclohexyltrimethylene, 2-isopropyltrimethylene, 2-isobutyltrimethylene, 2-cyclohexyltrimethylene, 1-methyltetramethylene, 1-isopropyltetramethylene, 1-isobutyltetramethylene, 1-cyclopetnyltetramethylene, 1-cyclohexyltetramethylene, 2-methyltetramethylene, 2-isopropyltetramethylene, 2-isobutyltetramethylene, 2-cyclopentyltetramethylene, 2-cyclohexyltetramethylene, 1-methylpentamethylene, 1-ethylpentamethylene, 1-isopropylpentamethylene, 1-isobutylpentamethylene, 1-cyclopentylpentamethylene, 1-cyclohexylpentamethylene, 2-methylpentamethylene, 2-ethylpentamethylene, 2-isopropylpentamethylene, 2 isobutylpentamethylene, 2-cyclopentylpentamethylene, 2-cyclohexylpentamethylene, methylpentamethylene, 3-ethylpentamethylene, 3-isopropylpentamethylene, 3-isobutylpentamethylene, 3-cyclopentylpentamethylene, 3-cyclohexylpentamethylene, 1-methylhexamethylene, 1-ethylhexamethylene, 1-isopropylhexamethylene, 1-isobutylhexamethylene, 1-cyclopentylhexamethylene, 1-cyclohexylhexamethylene, 2-methylhexamethylene, 2-ethylhexamethylene, 2-isopropylhexamethylene, 2-isobutylhexamethylene, 2-cyclopentylhexamethylene, 2-cyclohexylhexamethylene, 3-methylhexamethylene, 3-ethylhexamethylene, 3-isopropylhexamethylene, 3-isobutylhexamethylene, 3-cyclopentylhexamethylene, 3-cyclohexylhexamethylene, 1-methylheptamethylene, 1-ethylheptamethylene, 1-isopropylheptamethylene, 1-isobutylheptamethylene, 1-cyclopentylheptamethylene, 1-cyclohexylheptamethylene, 2-methylheptamethylene, 2-ethylheptamethylene, 2-isopropylheptamethylene, 2-isobutylheptamethylene, 2-cyclopentylheptamethylene, 2-cyclohexylheptamethylene, 3-methylheptamethylene, 3-ethylheptamethylene, 3-isopropylheptamethylene, 3-isobutylheptamethylene, 3-cyclopentylheptamethylene, 3-cyclohexylheptamethylene, 1-methyloctamethylene, 1-ethyloctamethylene, 1-isopropyloctamethylene, 1-isobutyloctamethylene, 1-cyclopentyloctamethylene, 1-cyclohexyloctamethylene, 2-methyloctamethylene, 2-ethyloctamethylene, 2-isopropyloctamethylene, 2-isobutyloctamethylene, 2-cyclopentyloctamethylene, 2-cyclohexyloctamethylene, 3-methyloctamethylene, 3-ethyloctamethylene, 3-isopropyloctamethylene, 3-isobutyloctamethylene, 3-cyclopentyloctamethylene, 3-cyclohexyloctamethylene, 1-methylnonamethylane, 1-ethylnonamethylene, 1-isopropylnonamethylene, 1-isobutylnonamethylene, 1-cyclopentylnonamethylene, 1-cyclohexylnonamethylene, 2-methylnonamethylene, 2-ethylnonamethylene, 2-isopropylnonamethylene, 2-isobutylnonamethylene, 2-cyclopentylnonamethylene, 2-cyclohexylnonamethylene, 3-methylnonamethylene, 3-ethylnonamethylene, 3-isopropylnonamthylene, 3-isobutylnonamethylene, 3-cyclopentylnonamethylene, 1-methyldecamethylene, 1-ethyldecamethylene, 1-isopropyldecamethylene, 1-isobutyldecamethylene, 1-cyclopentyldecamethylene, 1-cyclohexyldecamethylene, 2-methyldecamethylene, 2-ethyldecamethylene, 2-isopropyldecamethylene, 2-isobutyldecamethylene, 2-cyclopentyldecamethylene, 2-cyclohexyldecamethylene, 3-methyldecamethylene, 3-ethyldecamethylene, 3-isopropyldecamethylene, 3-isobutyldecamethylene, 3-cyclopentyldecamethylene, and 3-cyclohexyldecamethylene groups; (2) cycloalkylene groups, for example, C₅-C₈-cycloalkylene groups such as 1,2-cyclopentylene, 1,3-cyclopentylene, 1,2-cyclohexylene, 1,3-cyclohexylene, 1,4-cyclohexylene, 1,2-cycloheptyl, 1,3-cycloheptyl, and 1,4-cycloheptyl groups; (3) alkenylene groups and alkynylene groups, for example, C₄-C₁₀-alkenylene groups and C₄-C₁₀-alkynylene groups such as 2-butenylene, 1-methyl-2-butenylene, 1-ethyl2-butenylene, 1-propylbutenylene, 1-butylbutenylene, 2-butenylene, 2-pentenylene, 2-pentynylene, 2-hexenylene, 3-hexenylene, 2-hexynylene, 3-hexynylene, 2-heptenylene, 3-heptenylene, 2-heptynylene, 3-heptynylene, 2-octenylene, and 4-octenylene groups; and (4) cycloalkylalkylene groups, for example, C₄-C₈-cycloalkylene-C₁-C₇-alkylene groups such as 1,1-pentamethyleneethylene, 1,1-tetramethyleneethylene, 1,1-hexamethyleneethylene, 1,1-tetramethylenetrimethylene, 1,1-pentamethylenetrimethylene, 1,2-trimethylenetrimethylene, 1,2-tetramethylenetrimethylene, 1,1-trimethylenepentamethylene, 1,1-tetramethylenepentamethylene, 1,1-pentamethylenepentamethylene, 1,2-trimethylenepentamethylene, 1,2-tetramethylenepentamethylene, 1,2-pentamethylenepentamethylene, 1,3-trimethylenepentamethylene, 1,1-trimethylenehexamethylene, 1,1-tetramethylenehexamethylene, 1,1-pentamethylenehexamethylene, 1,2-trimethylenehexamethylene, 1,2-tetramethylenehexamethylene, 1,2-pentamethylenehexamethylene, 1,3-trimethylhexamethylene, 1,1-trimethyleneheptamethylene, 1,1-tetramethylenehpetamethylene, 1,1-pentamethyleneheptamethylene, 1,2-trimethyleneheptamethylene, 1,2-trimethyleneheptamethylene, 1,2-tetramethyleneheptamethylene, 1,2-pentamethyleneheptamethylene, 1,3-trimethyleneheptamethylene, 1,1-trimethyleneoctamethylene, 1,1-tetramethyleneoctamethylene, 1,1-pentamethyleneoctamethylene, 1,2-trimethyleneoctamethylene, 1,2-tetramethyleneoctamethylene, 1,2-pentamethyleneoctamethylene, 1,1-trimethylenenonamethylene, 1,1-tetramethylenenonamethylene, 1,1-pentamethylenenonamethylene, 1,2-trimethylenenonamethylene, 1,2-tetramethylenenonamethylene, 1,2-pentamethylenenonamethylene, 1,3-trimethylenenonamethylene, 1,1-trimethylenedecamethylene, 1,1-tetramethylenedecamethylene, 1,1-pentamethylenedecamethylene, 1,2-trimethylenedecamethylene, 1,2-tetramethylenedecamethylene, 1,3-pentamethylenedecamethylene, and 1,3-trimethylenedecamethylene groups. The divalent aliphatic hydrocarbon groups described above may further be substituted with an aromatic group, for example, an aryl group such as phenyl or naphthyl group; or a heteroaryl group such as furyl, thienyl, pyridyl or indolyl group. Examples of such substituted divalent hydrocarbon group include phenylethylene, pyridylethylene, benzylethylene, naphthylmethylethylene, furylmethylethylene, thienylmethylethylene, pyridylmethylethylene, and indolylmethylethylene groups. The "divalent aromatic hydrocarbon group" may be either monocyclic or polycyclic, and examples thereof include phenylene and naphthylene groups. Their aromatic rings may be substituted with 1 to 4 lower alkyl groups. Further, the "divalent aromatic heterocyclic group" includes aromatic unsaturated heterocyclic groups which have at least one hetero atom selected from a nitrogen atom, an oxygen atom and a sulfur atom in the ring thereof. The heterocyclic group described above may form a condensed ring together with the above-described aromatic hydrocarbon ring. Examples of this type of divalent aromatic heterocyclic group includes pyridinediyl, pyrimidinediyl, pyrazinediyl, furanediyl, thiophenediyl, quinolinediyl, isoquinolinediyl, benzofuranediyl, benzothiophenediyl, benzoxazolediyl, benzothiazolediyl and indolediyl. Therefore, in the case where Q in formula (I) above represents the above-described group (a), A may preferably represent: (1) a linear or branched C₂-C₁₀-alkylene group, for example, ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, octamethylene, nonamethylene, decamethylene, propylene, ethylethylene, isopropylethylene, propylethylene, butylethylene, isobutylethylene, 1-methyltrimethylene, 1-ethyltrimethylene, 1-isopropyltrimethylene, 1-isobutyltrimethylene, 1-methyltetramethylene, 1-isopropyltetramethylene or 1-isobutyltetramethylene group; (2) a C₅-C₇-cycloalkyl-C₂-C₅-alkylene group, for example, cyclopentylethyl, cyclohexylethyl, cyclobutylethyl, 1-cyclopentyltrimethylene, 1-cyclohexyltrimethylene, 1-cyclopentyltetramethylene or 1-cyclohexyltetramethylene group; (3) a C₅-C₇-cycloalkylene group, for example, 1,2-cyclopentylene, 1,2-cyclohexylene, 1,3-cyclohexylene, 1,4-cyclohexylene, 1,2-cycloheptylene or 1,3-cycloheptylene; (4) a C₄-C₈-alkenylene group or a C₄-C₈-alkynylene group, for example, 2-butenylene, 1-methyl-2-butenylene, 1-ethyl-2-butenylene, 1-propylbutenylene, 1-butylbutenylene, 2-butynylene, 2-pentenylene, 2-pentynylene, 2-hexenylene, 3-hexenylene, 2-hexynylene, 3-hexynylene, 2-heptenylene, 3-heptenylene, 2-heptynylene, 3-heptynylene, 2-octenylene or 4-octenylene; (5) a C₅-C₇-cycloalkylene-C₁-C₅-alkylene group, for example, 1,1-pentamethyleneethylene, 1,1-tetramethyleneethylene, 1,1-hexamethyleneethylene, 1,1-dimethylethylene, 1,1-tetramethylenetrimethylene, 1,1-pentamethylenetrimethylene, 1,2-trimethylenetrimethylene or 1,2-tetramethylenetrimethylene; (6) a C₂-C₅-alkylene group substituted with an aryl group or a heteroaryl group, for example, phenylethylene, naphthylethylene, furylethylene, thienylethylene, pyridylethylene, benzylethylene, naphthylmethylethylene, furylmethylethylene, thienylmethylethylene, pyridylmethylethylene or indolylmethylethylene; or (7) o-phenylene, m-phenylene or p-phenylene; and one of X¹ and Y¹ may preferably represent -NH-or and the other may preferably represent -O, -S-, -NH-, Furthermore, in the case where Q in formula (I) above represents the group (b) described above, the 4- to 7-membered, preferably 5- or 6-membered divalent nitrogen-containing heterocyclic group represented by formula may include saturated nitrogen-containing heterocyclic groups, for example, and X² represents one of the nitrogen-containing heterocyclic groups, it may be bonded through its nitrogen atom to the left hand side carbonyl group in formula (I), and on the other hand when Y² represents the above-described nitrogen-containing heterocyclic group, it may be bonded through its nitrogen atom to the right hand side carbonyl group in formula (I) above. When X² represents one of the above-described nitrogen-containing heterocyclic groups, it is preferred that Y³ represent Particularly, it is preferred that one of X² and Y² represent and the other represent -O-, -S-, -NH- or Hence, representative examples of the compounds of formula (I) above provided by the present invention include the following compounds: Group a Compounds represented by the following formula (Ia) wherein R¹, R², R³, A, X¹, Y¹ and n are as defined above: N-[4-(Oleoyloxy)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[4-(Oleoyloxy)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; 4-(Oleoylamino)phenyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(Oleoylamino)phenyl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-[4-(Oleoylthio)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[4-(Oleoylthio)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; S-4-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanthioate; S-4-(Oleoylamino)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanthioate; N-[2-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; 2-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; N-[2-(Oleoyloxy)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[2-(Linoleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[2-(Linolenoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[2-(Stearoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[2-(Lauroylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[2-(Octanoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[3-(Linoleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-[4-(Lauroylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; 4-(Linoleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; N-[2-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-[2-(Oleoylamino)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-[3-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-[3-(Oleoylamino)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-[4-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-[4-(Oleoylamino)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; 4-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate; N-[4-(Oleoyloxy)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; S-4-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanthioate; N-[4-(Oleoylthio)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; 4-(Oleoylamino)phenyl]-3-[N-(2,4-dibenzyloxy-3,3-dimethyl-1-oxobutyl)amino]propionate; N-(2-Oleoylaminoethyl)-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-(3-N-Oleoylaminopropyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-(2-N-Oleoylaminoethyl)-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; 2-(N-Oleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(N-Oleoylamino)ethyl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 3-(N-Oleoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Oleoylamino)propyl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 3-(N-Oleoylamino)propyl-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 4-(N-Oleoylamino)butyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(N-Oleoylamino)butyl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate; S-2-(N-Oleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanthioate; S-2-(N-Oleoylamino)ethyl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanthioate; N-(3-Oleoylaminopropyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-(3-Oleoylaminopropyl)-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-(3-Oleoylaminopropyl)-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-(4-Oleoylaminobutyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-(4-Oleoylaminobutyl)-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-(4-Oleoylaminobutyl)-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-(6-Oleoylaminohexyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-(5-Oleoylaminopentyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-(8-Oleoylaminooctyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; N-(2-Oleoylaminoethyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide; 5-(N-Oleoylamino)pentyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 6-(N-Oleoylamino)hexyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(N-Methyl-N-oleoylamino)ethyl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Oleoylamino)propyl-3-[N-(2,4-dibenzoyloxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 3-(N-Oleoylamino)propyl-3-[N-(2-hydroxy-3,3-dimethyl-4-(trimethylacetyl)oxy-1-oxobutyl)amino]propionate; 3-(N-Oleoylamino)propyl-3-[N-(2-phenyl-5,5-dimethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Hexadecanoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Linoleoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Octadecanoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Tetradecanoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Dodecanoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Decanoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Octanoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-Hexanoylamino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(N-(2-Isopropylhexanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-t-Butylhexanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-t-Butylheptanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-t-Butylnonanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Diethylundecanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-Isopropyldodecanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-t-Butyltetradecanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-t-Butylhexadecanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-Isopropylheptadecanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-Ethyloctadecanoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-10-undecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-7-dodecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-7-tetradecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-9-tetradecenoyl)amino)propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-11-tetradecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-11-pentadecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-9-pentadecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-9-hexadecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-9-heptadecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2,2-Dimethyl-9-octadecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-[N-(2-Methyl-9-octadecenoyl)amino]propyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; N-[2-(Oleoylamino)cyclohexane-1-yl]-3-[N-{(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl}amino]propanamide; N-[(1S,2S)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-{(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl}amino]propanamide; N-[(1R,2R)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-{(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl}amino]propanamide; N-[(1S,2S)-2-(Oleoylamino)cyclohexane-1-yl)-3-[N-{(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl}amino]propanamide; N-[2-(Oleoylamino)cyclohexane-1-yl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide; N-[(1S,2S)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino] propanamide; N-[(1R,2R)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino] propionate; N-[(1S,2S)-2-(Oleoylamino)cyclohexane-1-yl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino] propionate; N-[(1R,2R)-2-(Stearoylamino)cyclohexane-1-yl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino] propionate; N-[(1S,2S)-2-(Linoleoylamino)cyclohexane-1-yl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino] propionate; 2-(1-Octylcyclobutanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Nonylcyclobutanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(Oleoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(Oleoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylcyclobutanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Undecylcyclobutanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Pentadecylcyclobutanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(9-Octadecenyl)cyclobutanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylcyclobutanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylcyclohexanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Nonylcyclohexanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-(9-Octadecenyl)cyclohexanoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Isopropylpentylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Isopropylhexylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-t-Butyldodecylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethylhexadecylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Octadecylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyloctadecylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-9-decenylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-6-undecenylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-8-tridecenylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Methyl-10-pentadecenylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-10-heptadecenylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Methyl-8-heptadecenylcarbamoylamino)cyclohexane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Octadecenylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(8,11-Octadecadienylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Methyl-8,11,14-octadecatrienylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Hexylcyclobutylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclobutylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclopentylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclohexylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclopentylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylcyclopentylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Hexylcyclohexylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(6-Hexadecenyl)cyclohexylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(6-Hexadecenyl)cyclobutylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(6-Hexadecenyl)cyclopentylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-Decylhexylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Hexyloctylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Butyldodecylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Methyloctadecylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[Butyl(1,1-dimethyl-6-undecenylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[Butyl(1,1-dimethyl-8-tridecenylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[Butyl(1-methyl-10-pentadecenylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[(8-Pentadecenyl)propylcarbamoylamino)]cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[Butyl(1,1-dimethyl-8-heptadecenylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[Ethyl(1,1-dimethyl-8-heptadecenylcarbamoylamino)cyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Ethyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Isopropyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Isobutyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2,2-Pentamethylene-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Phenyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Benzyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Naphthyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Furyl)-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Cyclopentyl-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(3-Indolyl)-2-(N-oeloylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(N-Oleoylamino)-2-butenyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(N-Oleoylamino)-2-butynyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-(1-Undecylcyclobutanecarbonyl)amino]cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-(1-Pentadecylcyclobutanecarbonyl)amino]cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-[1-(9-Octadecenyl)cyclobutanecarbonyl)amino]cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-(1-Decylcyclopentanecarbonyl)amino]cyclopentan 1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-(1-Tridecylcyclopentanecarbonyl)amino]cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-(1-Decylcyclohexanecarbonyl)amino]cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-(1-Nonylcyclohexanecarbonyl)amino]cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-[1-(9-Octadecenyl)cyclohexanecarbonyl)amino]cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[N-[1-(Isopropylpentylcarbamoyl)amino]cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Isopropylhexylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-t-Butyldodecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethylhexanedecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Octadecylcarbamoylamino)cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyloctadecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-9-decylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-6-undecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-8-tridecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Methyl-10-pentadecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1,1-Dimethyl-10-heptacarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Methyl-8-heptadecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(8-Octadecylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(8,11-Octadecadienylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Methyl-8,11,14-octadecatrienylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Hexylcyclobutylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclobutylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclopentylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclohexylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Heptylcyclopentylcarbamoylamino)cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylcyclopentylcarbamoylamino)cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Hexylcyclohexylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(6-Hexadecenyl)cyclohexylcarbamoylamino)cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(6-Hexadecenyl)cyclobutylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(6-Hexadecenyl)cyclopentylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylhexylcarbamoylamino)cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Hexyloctylcarbamoylamino)cycloheptan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[Butyl(1,1-dimethyl8-heptadecenylcarbamoylamino)cyclopentan-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-(N-linoleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-[N-(2-isopropylhexanoyl)amino]ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-[N-(2-t-butylheptanoyl)amino]ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-[N-(2,2-dimethylundecanoyl)amino]ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-[N-(2,2-trimethylenedecanoyl)amino]ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-(N-linolenoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Isopropyl-2-[N-(2-isopropylheptadecanoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Isobutyl-2-[N-(2-ethyloctadecanoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2,2-Pentamethylene-2-(N-linoleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Phenyl-2-(N-linoleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino]propionate 2,2-Diphenyl-2-(N-linoleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino] propionate; 2-Benzyl-2-(N-linoleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate 2,2-Bisbenzyl-2-(N-linoleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2,2-Naphthyl-2-[N-(2,2-dimethyl-9-tetradecenoyl)aminoethyl-3-[N- (2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Furyl)-2-[N-(2,2-dimethyl-9-octadecenoyl)amino]ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Cyclopentyl-2-[N-(2,2-dimethyl-9-octadecenoyl)amino]ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(3-Indolyl)methyl-2-(N-linoleoylamino)ethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(8-Heptadecenylcarbamoylamino)cyclohexane-1-yl-2-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]acetate; 2-(1-Methyl-8-heptadecenylcarbamoylamino)cyclohexane-1-yl-4-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]butyrate; and 2-(1-Methyl-8-heptadecenylcarbamoylamino)cyclohexane-1-yl-5-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]valerate. Group b Compounds represented by formula (Ib) wherein R¹, R², R³, X², Y², ℓ and n are as defined above: 2-Dodecanoylaminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-Octanoylaminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine: 2-Decanoylaminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-Tetradecanoylaminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-Hexadecanoylaminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-Octadecanoylaminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(7-Decanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(9-Tridecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(9-Octadecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(9,12-Octadecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(9,12,15-Octadecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(2-Methyl-9-octadecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl)pyrrolidine; 2-(2,2-Dimethyl-9-octadecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl) amino]propanoyl]pyrrolidine; 2-(2-Methyldecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(2-Methyloctanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(2-Methylundecanoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 2-(9-Octadecenoyl)aminomethyl-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 3-(9-Octadecenoyl)amino-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]piperidine; 3-(9-Octadecenoyl)amino-1-[3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanoyl]piperidine; 1-(9-Octadecenoyl)amino-3-[3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanoyl]aminopiperidine; 1-(9-Octadecenoyl)amino-3-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]aminopiperidine; 1-(9-Octadecenoyl)amino-4-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]aminopiperidine; 1-(9-Octadecenoyl)-4-piperidinyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 1-(9-Octadecenoyl)-4-piperidinyl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 1-(9-Octadecenoyl)-4-piperidinyl-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 1-(9-Octadecenoyl)-3-piperidinyl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 1-(9-Octadecenoyl)-3-piperidinyl-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 1-(9-Octadecenoyl)-2-pyrrolidinylmethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 1-Octadecenoyl-2-pyrrolidinylmethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 1-(9,12-Octadecenoyl)-2-pyrrolidinylmethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 1-(9-Octadecenoyl)-2-pyrrolidinylmethyl-3-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 1-(9-Octadecenoyl)-2-pyrrolidinylmethyl-3-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 1-(9-Octadecenoyl)-2-pyrrolidinylmethyl-2-[3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]-1-oxopropyl]aminomethylpyrrolidine; 2-[(8-Heptadecenylcarbamoyl)aminomethyl]-1-[3-N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 3-[(8-Heptadecenylcarbamoyl)aminomethyl]-1-[3-N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]piperidine; 1-[(8-Heptadecenylcarbamoyl)aminomethyl]-3-[3-N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]piperidine; 1-[(8-Heptadecenylcarbamoyl)aminomethyl]-2-[3-N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]pyrrolidine; 4-(8-Heptadecenylcarbamoyl)amino-1-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]piperidine; 1-(8-Heptadecenylcarbamoyl)-4-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]aminopiperidine; 1-(8-Heptadecenylcarbamoyl)-4-piperidinyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 1-(8-Heptadecenylcarbamoyl)-3-piperidinyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; and 1-(8-Heptadecenylcarbamoyl)-2-piperidinyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate. Group c Compounds represented by formula (Ic) below: wherein R¹, R², R³, m and n are as defined above: 1-Hexanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-Heptanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-Octanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-Decanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-undecanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-Tetradecanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-Hexadecanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-Octadecanoyl-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(7-Tetradecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(10-Hexadecanoyl)-4-(1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(9-Octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(13-Octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(9,12-Octadecadienoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(9,12,15-Octadecadienoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(2-Methylheptadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(2,2-Dimethylheptadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(2-Methylheptadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(2,2-Dimethyloctadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(2-Methyl-9-octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(2-Ethyl-9-octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(2,2-Dimethyl-9-octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(9-Octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-dihydroxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(9-Octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2-hydroxy-4-benzoyloxy-3,3-dimethylbutyl)amino]propyl] piperazine; 1-(9-Octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2,4-dibenzoyloxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(9-Octadecanoyl)-4-[1-oxo-3-[N-(1-oxo-2-hydroxy-4-pivaloyloxy-3,3-dimethylbutyl)amino]propyl]piperazine; 1-(9-Octadecenoyl)-4-[1-oxo-3-[N-(1-oxo2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl]tetrahydro-1,4-diazepine; 1-(9-Octadecenoyl)-4-[1-oxo-3-[N-(1-oxo2,4-dihydroxy-3,3-dimethylbutyl)amino]propyl]tetrahydro-1,4-diazepine; 1-(9-Octadecenoyl)-4-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]piperazine; 1-(9-Octadecenoyl)-4-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]tetrahydro-1,4-diazepine; 1-(9-Octadecenoyl)-4-[3-[N-(2-phenyl-5,5-dimethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]piperazine; 1-(8-Heptadecenyl)carbamoyl-4-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanoyl]piperazine; 1-(8,11-Heptadecadienyl)carbamoyl-4-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanoyl]piperazine; 1-(8,11,14-Heptadecatrienyl)carbamoyl-4-[3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanoyl]piperazine; 1-(8-Heptadecenyl)carbamoyl-4-[3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanoyl]tetrahydro-1,4-diazepine; 2-(2-Benzylmethylcapryloyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propionate; 3-(2-Benzylmethylcapryloyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Benzylundecanoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(2-Benzylundecanoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(2-Benzylundecanoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Benzyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(2-Benzyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(2-Phenyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Phenyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(2-Benzylcapryloyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2,2-Diphenyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dihydroxy-3,3-dimethyl-1-oxobutyl)amino] propionate; 2-(2-Benzylcyclopentanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[1-(3-Phenylpropylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Furfurylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Cinnamylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(N-Benzyl-N-hexylcarbamoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(N-Benzyl-N-octylcarbamoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(N-Benzyl-N-decylcarbamoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; (Z)-4-Oleoylamino-2-butenyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methylo-2-oleoylaminoethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)cyclopentane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)cyclopentane-2-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 1-Methyl-2-oleoylaminoethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)2-phenylethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(Oleoylamino)2-butynyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; (E)-4-(oleoylamino)-2-butenyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Methyl-2-oleoylaminoethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 1-Methyl-2-oleoylaminoethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Oleoylaminobutyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-Methyl-2-oleoylaminobutyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)cycloheptanel-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)cycloheptanel-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(Oleoylamino)2-phenylethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Oleoylamino-2-cyclohexylethyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-Methyl-2-oleoylaminopentyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Oleoylaminopentyl-3-phenylpropyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Oleoylamino-1-pentylpropyl-3-phenylpropyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Methyloleoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2,2-Dimethyloleoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2,2-Dimethylstearoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-Oleoylamino-2-phenylethyl)-5-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]pentanoate; 2-Oleoylamino-2-phenylethyl)-4-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]butanoate; 2-(2-Propylstearoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Ethylmyristoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(2-Ethylmyristoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Methylpalmitoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(2-Methylpalmitoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[(1-Methyl-8-heptadecenyl)carbamoyl]aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Oleylcyclopentanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Laurylcyclopentanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(2-Propylstearoyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Hexylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 4-(2-Isopropyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Isopropyllauroyl)aminocyclohexane-2-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Octylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-[(1-Methylpentadecenyl)carbamoyl]aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino[propionate; 2-(2-Decyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(2-Methyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 3-(1-Methyllauroyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; 2-(1-Decylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate; 2-(1-Butylcyclobutanecarbonyl)aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate; and 2-[N-(2,2-Dimethylpropyl)-N-nonylcarbamoyl]aminocyclohexane-1-yl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate. The compounds of the present invention have at least one asymmetric carbon atom as indicated by an asterisk (*) in formula (I) and may include any of optically active isomers (R-form or S-form) and racemi form compounds. The compound of the present invention represented by formula (I) above can be prepared by (a) reacting a compound of formula (II) wherein R¹¹ and R²¹, which are the same or different, each represent a protected hydroxyl group, Q and n have the same meanings as defined above; with a compound of formula (III) or (IV) below R³-COZ¹ (III) R⁴-NCO (IV) wherein Z¹ represents a hydrogen atom; a halogen atom such as chlorine or bromine; an alkoxy group such as methoxy or ethoxy; a substituted or unsubstituted phenyloxy group such as phenoxy, p-nitrophenoxy, 2,4-dinitrophenoxy; and R³ and R⁴ have the same meanings as defined above; or (b) reacting a compound of formula (V) below wherein R¹¹, R²¹, n and Z¹ have the same meanings as defined above; with a compound of formula (VI) H-Q-CO-R³ (VI) wherein R³ and Q have the same meanings as defined above; or (c) eliminating the protective group for the hydroxyl group(s) in the resulting compound of formula (I-1) below wherein R¹¹ and R²¹, R³ and n have the same meanings as defined above. The reaction between the compound of formula (II) and the compound of formula (III) in the process (a) above and the reaction between the compound of formula (V) and the compound of formula (VI) in the process (b) above can be carried out in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such a ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachlorine; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds generally at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the processes (a) and (b) above, a catalyst or a reaction accelerator may be used. As for the catalyst or reaction accelerator which can be used in the present invention, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, diisopropylamine and pyridine; and the like. The catalysts or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mol of the compound (II) or (III). The proportion of the compound (III) or (IV) to the compound (II) is not limited strictly but can be usually in a range of from 0.8 to 1.2 moles, preferably from 1.0 to 1.1 moles, per mole of the compound (II). Similarly, the proportion of the compound (V) can be used in an amount in a range of from 0.8 to 1.2 moles, preferably from 1.0 to 1.1 moles, per mole of the compound (VI). In the process (c), the reaction which eliminates the protective groups for the hydroxyl groups from the compound of formula (I-1) can be performed, for example, by hydrolysis in a solvent in the presence of a suitable catalyst. For example, the reaction can be carried out in a single solvent or a mixed solvent selected from aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; water; organic acids such as acetic acid and propionic acid; ketones such as acetone and methyl ethyl ketone; and the like at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. As for the catalyst which can be used, there can be cited, for example, inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine diisopropylamine and pyridine; minetal acids such as hydrochloric acid, nitric acid and sulfuric acid; hydrogen halides such as hydrogen fluorine, hydrogen bromide and hydrogen iodide; organic acids such as trifluoroacetic acid and trichloroacetic acid; and the like. The protective groups can be eliminated from the compounds of formula (I-1) by a conventional catalyst hydrogenation reaction using a suitable metal catalyst. As for the metal catalyst, there can be used commonly used hydrogenation catalysts such as nickel, palladium, rhodium and platinum. The products obtained by each of the above-described processes can be separated from the reaction mixtures or purified by proper combinations of known processes, for example, crystallization, chromatography, extraction and filtration. In the above-described processes, the compounds of formulae (V), (II) and (VI) used as starting materials can be produced as follows. Preparation of Compound of Formula (V) In the above formulae, M represents a hydrogen atom, an alkali metal atom such as sodium and potassium or an alkaline earth metal atom such as magnesium and calcium: L represents OH, Cl, Br, I or N₂; and R¹¹, R²¹, n and Z¹ have the same meanings as defined above. Hereafter, explanation will be made on each step more specifically. Step-1: This step is to synthesize a compound of formula (V-a) by reacting pantolactone with an ω-aminocarboxylic acid. Pantolactone may be any one of (D)-, (L)- ane (DL)-forms. Examples of the ω-aminocarboxylic acid include aminoacetic acid (glycine), 3-aminopropionic acid (β-alanine), 4-aminobutyric acid (γ-aminobutyric acid, abbreviated as "GABA") and 5-aminovaleric acid. It is preferred that the reaction be carried out in a solvent. As for the solvent, there can be used, for example, aromatic hdyrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds generally at a temperature in a range of from about 0°C to the boiling temperature of the solvent used, preferably from room temperature to the boiling temperature of the solvent used. In this reaction, it is preferred to use a catalyst. As for the catalyst, there can be used, for example, inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; and the like. The catalysts may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mole of pantolacone. Step-2: This step is to benzylate the compound of formula (V-a) synthesized in Step-1 using a benzylation reagent to a compound of formula (V-b). As for the benzylation reagent, there can be used, for exmaple, benzyl halides such as benzyl chloride, benzyl bromide and benzyl iodide; benzyl alcohol; phenyldiazomethane; and the like. The reaction can be carried out in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachlorine; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; ketones such as acetone and methyl ethyl ketone; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of teh solvent used. In the reaction, a catalyst or a reaction accelerator may be used. As for the catalyst or reaction accelerator, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; and the like. The catalysts or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents pler mole of the compound of formula (V-a). Step-3: This step is to protect the hydroxyl groups of the compound of formula (V-b) in Step-2 above using a reagent for introducing protective groups to synthesize a compound of formula (V-c). As for the reagent for introducing protective groups (R¹¹, R²¹), there can be used acid anhydrides such as acetic anhydride and benzoic anhydride; acid chlorides such as acetyl chloride and benzoyl chloride; organic acids such as acetic acid, benzoic acid and p-toluenesulfonic acid; ortho esters such as ethyl orthoformate and methyl orthoformate; ketones such as acetone and cyclohexanone; aldehydes such as benzaldehyde and acetaldehyde;Silylation agent such as trimethylsilyl chloride and dimethylphenylsilyl chloride; alkylation agents such as diazomethane and dimethyl sulfate; alkyl halides such as methyl iodide and benzyl chloride; and the like. The reaction can be carried out in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as dmethylene chloride, chloroform and carbon tetrachloride; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; ketones such as acetone and methyl ethyl ketone; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaciton proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the reaction, a catalyst or a reaciton accelerator may be used. As for the catalyst or reaction accelerator, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylminopropyl)carbodiimide hydrochloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; organic acids such as acetic acid, p-toluenesulfonic acid and camphorsulfonic acid; and the like. The catalysts or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mole of the compound of formula (V-b). Step-4: This step is to hydrolyze or catalytically hydrogenate the compound of formula (V-c) to convert it to a compound of formula (V-d). The reaction can be carried out in a solvent in the presence of a suitable catalyst. The hydrolysis can be performed in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; ketones such as acetone and methyl ethyl ketone; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the reaction, a catalyst may be used. As for the catalyst, there can be cited, for example, inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; mineral acids such as hydrochloric acid, nitric acid and sulfuric acid; hydrogen halides such as hydrogen fluoride, hydrogen bromide and hydrogen iodide; organic acids such as trifluoroacetic acid and trichloroacetic acid; and the like. On the other hand, the catalytic hydrogenation can be carried out by a conventional process known per se using a metal catalyst. As the metal catalyst, there can be used, for example, nickel palladium, rhodium and platinum a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride; high boiling point polar solvents such as dimethylformaide and dimethylsulfoxide; alcohols such as methanol and ethanol; ketones such as acetone and methyl ethyl ketone; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the reaction, a catalyst or a reaction accelerator may be used. As for the catalyst or reaction accelerator, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; organic acids such as acetic acid, p-toluenesulfonic acid and camphorsulfonic acid; and the like. The catalysts or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mole of the compound of formula (V-b). Step-5: This step is to convert the compound of formula (V-d) to the compound of formula (V). The reagent used in the reaction includes, for example, halogenating agents such as thionyl chloride, phosphorus oxychloride and phosphorus pentachloride; or esterifying agents, e.g., alcohols such as methanol and ethanol; and phenols such as p-nitrophenol and 2,4-dinitrophenol. The reaction in this step can be carried out in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the reaction, a catalyst or a reaction accelerator may be used. As for the catalyst or reaction accelerator, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; and the like. The catalysts or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mole of the compound of formula (V-d). Step-6: This step is to synthesize the compound of formula (V-d) from the compound of formula (V-a). The reagent which can be reacted with the compound of formula (V-a) includes acid anhydrides such as acetic anhydride and benzoic anhydride; acid chlorides such as acetyl chloride and benzoyl chloride; organic acids such as acetic acid, benzoic acid and p-toluenesulfonic acid; ortho esters such as ethyl orthoformate and methyl orthoformate; ketones such as acetone adn cyclohexanone; aldehydes such as benzaldehyde and acetaldehyde; silylation agent such as trimethylsilyl chloride and dimethylphenylsilyl chloride; alkylation agents such as diazomethane and dimethyl sulfate; alkylhalides such as methyl iodide and benzyl chloride; and the like. The reaction can be carried out in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydroarbons such as methylene chlorine, chloroform and carbon tetrachlorine; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; ketones such as acetone and methyl ethyl ketone; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the reaction, a catalyst or a reaction accelerator may be used. As for the catalyst or reaction accelerator, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; organic acids such as acetic acid, p-toluenesulfonic acid and camphorsulfonic acid; and the like. The catalysts or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mole of the compound of formula (V-a). Preparation of Compound of Formula (II) The compound of formula (II) can be obtained by reacting the compound of formula (V) wherein R¹¹, R²¹, n and Z¹ have the same meanings as defined above; with a compound of formula (VII) H-Q-H (VII) wherein Q has the same meaning as defined above. This reaction can be carried out in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chlorine, chloroform and carbon tetrachloride; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the reaction, a catalyst or a reaction accelerator may be used. As for the catalyst or reaction accelerator, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; halogenating agents such as thionyl chloride, phosphorus oxychloride and phosphorus pentachloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic based such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyriidine; organic acids such as acetic acid, p-toluenesulfonic acid and camphorsulfonic acid; and the like. The catalyst or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mole of the compound of formula (V). Preparation of Compound of Formula (VI) The compound of formula (VI) can be obtained by reacting the compound of formula (VII) H-Q-H (VII) wherein Q has the same meaning as defined above. with a compound of formula (VIII) R³-CO-Z¹ (VIII) wherein R³ and Z¹ have the same meanings as defined above. H-Q-H (VII) wherein Q has the same meanning as defined above. This reaction can be carried out in a suitable solvent, for example, aromatic hydrocarbons such as benzene, toluene and xylene; ethers such as ethyl ether, tetrahydrofuran and dioxane; esters such as methyl acetate and ethyl acetate; halogenated hydrocarbons such as methylene chloride, chloroform and carbon tetrachloride; high boiling point polar solvents such as dimethylformamide and dimethyl sulfoxide; alcohols such as methanol and ethanol; water, and the like. The solvents may be used singly or two or more of the solvents may be used as mixtures. The reaction proceeds usually at a temperature in a range of from about -78°C to the boiling temperature of the solvent used, preferably from about -10°C to the boiling temperature of the solvent used. In the reaction, a catalyst or a reaction accelerator may be used. As for the catalyst or reaction accelerator, there can be cited, for example, carbodiimides such as dicyclohexylcarbodiimide, diisopropylcarbodiimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; halogenating agents such as thionyl chloride, phosphorus oxychloride and phosphorus pentachloride; acid anhydrides such as acetic anhydride and benzoic anhydride; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate; organic bases such as triethylamine, diethylamine, dimethylamine, diisopropylamine and pyridine; organic acids such as acetic acid. p-toluenesulfonic acid and camphorsulfonic acid; and the like. The catalysts or reaction accelerators may be used in amounts in a range of from 0.01 to 10 equivalents, preferably from 0.1 to 1.1 equivalents per mole of the compound of formula (VII). The compounds of the general formula (I) provided by the present invention have an excellent ACAT inhibiting activity and are expected to be useful as drugs for the therapy, treatment or prevention of hyperlipemia, arteriosclerosis, angina pectoris, myocardial infraction, thrombosis and the like. The ACAT inhibiting activity of the compounds of the present invention can be confirmed by the test method described below. ACAT inhibition tests were carried out by measuring cholesteryl oleate produced from [1-¹⁴C]-oleoyl-CoA and endocellular cholesterol similarly to the method of Helgerud et al. [cf. Journal of Lipid Research , 22 , 497 (1987)] and the method of Folch et al. [cf. Journal of Biological Chemistry , 226 , 497 (1957)]. More specifically, 10 µl of a solution of a microsome fraction prepared from a rat liver (0.3 mg protein) in 0.514 M potassium phosphate buffer (pH 7.4) and 5 µl of a solution of 10⁻⁷ M of a test drug in dimethyl sulfoxide were added to 0.5 ml of a solution of 2 µM [1-¹⁴C]oleoylCoA in 0.514 M potassium phosphate buffer, and the mixture was allowed to react at 37°C for 4 minutes. Thereafter, 4.2 ml of methanol and 8.3 ml of chloroform were added to the reaction mixture to stop the reaction. Then, 2.5 ml of water was added and after shaking the mixture sufficiently a chloroform layer was separated. After concentrating it, the chloroform layer was subjected to thin layer chromatography. The cholesteryl oleate formed was separated and its radioactivity ws measured by a liquid scientilaltion counter. On the other hand, the same tests as above were repeated without using test compounds. The radioactivity of the control thus obtained was used as a standard for calculating the ACAT inhibiting activity of each test compound. The results obtained are shown in Tables 1a, 1b and 1c. In the case where the compounds of the present invention are used as a drug for the therapy, treatment or prevention of various diseases such as hyperlipemia, arteriosclerosis, angina pectoris, myocardial infraction and thrombosis, the compounds can be formulated together with pharmaceutically accepted carriers, diluents, excipients, binders, disintegrants, lubricants, antiseptics, stabilizers, dissolving aids, corrigents or the like into formulations suitable for administration such as those unit administration formulas, for example, tablets, capsules, powders, granules, microcapsules, syrups, elixirs, injectable liquids and suppositories. While the contents of the active ingredients in the formulations will vary depending on the kinds of the compounds of as the present invention used, types of the formulations, purposes for which the formulations are used, generally the active ingredients are contained in a range of from 0.5 to 90% by weight, and preferably from 5 to 60% by weight. In the case of solid preparations such as tablets, capsules, powders and granules, the compounds of the present invention can be formulated in a conventional manner together with carriers or diluents such as lactose, mannitol, glucose, hydroxypropylcellulose, crystallite cellulose, carboxymethylcellulose, starch, polyvinylpyrrolidone, aluminum metasilicate and talc; lubricants such as magnesium stearate; disintegrants such as cellulose calcium gluconate; dissolving aids such as glutamic acid and aspartic acid; stabilizers such as lactose; and the like. The tablets may if desired be coated with a substance which is soluble in the stomach or intestine such as white sugar, gelatin, hydroxypropylmethylcellulose. The capsules may be either hard capsules or soft capsules. In the case of liquid formulations such as syrups, elixirs, solutions, emulsions and suspensions, the compounds of the present invention can be formulated by dissolving or dispersing them in a pharmaceutically acceptable liquid medium such as deionized water, physiological saline, buffers and ethanol, and optionally adding thereto one or more substances selected from surfactants, edulcorants, corrigents, flavors and antiseptics. On the other hand, injections, which are administered parenterally, include sterile, aqueous or non-aqueous solutions, suspensions and emulsions. Such types of injections can be prepared by mixing the compounds of the present invention with aqueous diluents such as distilled water for injection and physiological saline or non-aqueous diluents such as polyethylene glycol, propylene glycol, olive oil, ethanol and polysolvate 80 (trademark). The injections may contain one or more auxiliaries such as antiseptics, wetting agents, surfactants, dispersants, stabilizers and dissolving aids, if desired. The injections can be sterilized usually by filtering them through bacteria trapping filters or by blending or spraying sterilizers. Furthermore, it is also possible to use solid formulations prepared by lyophilization or the like after the abovedescribed treatments and in addition thereto adding sterilized water or diluent for injection immediately before use. The compounds of the present invention can be administered by oral administration or rectal administration, or alternatively by parenteral administration such as intravenous administration, intramuscular administration and subcutaneous administration. While their dosage will vary depending on the kinds of the compounds to be used, administration methods, severity of symptoms of patients to be treated, age and body weight of patients and judgements by the doctors, it is suitable that the compounds of the present invention are administered generally in a dosage of from about 2 to about 500 mg/kg/day once a day or dividedly 2 to 4 times a day. However, the dosage is not limited to the above-described conditions but dosage either higher or lower than the above-described one may of course be used depending on the judgements by the doctors and severity of the symptoms. Hereafter, the present invention will be explained in greater detail with reference to nonlimitative examples. Reference Example 1 Preparation of Benzyl 3-[N-(2,4-Dihydroxy-3,3 -dimethyl-1-oxo)amino]propionate A solution of 75 g of calcium pantothenate and 53.8g of benzyl bromide in 1 liter of diemthylformamide was stirred at 100°C for one night. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in water extracted with ethyl acetate. The organic layer was washed with water and then with saturated saline, and dried over anhydrous sodium sulfate. Removal of the solvent by evaporation afforded 90.3 g of the objective compound (yield: 93%). Property: Oily IR(cm⁻¹, neat): νCO 1738, 1662 Mass Spectrometric Analysis: Molecular formula C₁₆H₂₃NO₅ Calculated 309.1576 Found 309.1577 NMR(δ, CDCl₃) : 0.88 (3H,s), 1.00 (3H,s), 2.62 (2H,t,J=7Hz), 3.45 (1H,d,J=11Hz), 3.48 (1H,d,J=11Hz), 3.52-3.64 (2H,m), 3.99 (1H,s), 5.14 (2H,s), 7.10-7.20 (1H,m), 7.33-7.42 (5H,m) Reference Example 2 Preparation of Benzyl 3-[N-(2,2,5,5-Tetramethyl -1,3-dioxane-4-carbonyl)amino]propionate p-Toluenesulfonic acid hydrate (5.6 g) was added to solution of 90 g of benzyl 3-[N-(2,4-dihydroxy-3,3,-dimethyl-1-oxo)amino]-propionate in 700 ml of acetone, and the mixture was stirred at room temperature for one night. After completion of the reaction, the solvent was disstilled off under reduced pressure. The residue was dissolved in ethyl acetate, washed with saturated aqueous sodium bicarbonate solution, with water and then with extracted with ethyl acetate. The organic layer was washed with saturated saline, and dried over anhydrous sodium sulfate. The residue was subjected to silica gel column chromatography and purified to obtain 85 g of the objective compound (yield: 84%). Property: Oily IR(cm⁻¹, neat): νNH 3456 νCO 1740,1676 Mass Spectrometric Analysis: Molecular formula C₁₉H₂₇NO₅ Calculated 349.1889 Found 349.1882 NMR(δ, CDCl₃): 0.94 (3H,s), 1.03 (3H,s), 1.41 (3H,s), 1.44 (3H,s), 2.62 (2H,t,J=7Hz), 3.28 (1H,d,J= 12Hz), 3.67 (1H,d,J=12Hz), 3.42-3.65 (2H,m), 4.07 (1H,s), 5.14 (2H,s), 6.90-7.10 (1H,m), 7.30-7.40 (5H,m) Reference Example 3 Preparation of 3-[N-(2,2,5,5-Tetramethyl-1,3 -dioxane-4-carbonyl)amino]propionic Acid An aqueous 1N sodium hydroxide solution (100 ml) was added to a solution 35 g of benzyl 3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate in 350 ml of methanol, and the mixture was stirred under ice cooling for 1 hour. After completion of the reaction, methanol was distilled off under reduced pressure. The aqueous layer was extracted with ethyl acetate. After adding 1N hydrochloric acid to the aqueous layer to render it acidic, the aqueous layer was extracted with ethyl acetate. The organic layer washed with water and then with saturated saline, and dried over anhydrous sodium sulfate. Removal of the solvent by evapoation afforded 20.4 g of the objective compound (yield: 78%). Property: Melting point, 87.2 to 89.2°C IR(cm⁻¹, neat): νMH 3420, νCO 1734,1636 Mass Spectrometric Analysis: Molecular formula C₁₂H₂₁NO₅ Calculated 259.1419 Found 259.1425 NMR(δ, CDCl₃): 0.98 (3H,s), 1.04 (3H,s), 1.43 (3H,s), 1.46 (3H,s), 2.62 (2H,t,J=7Hz), 3.29 (1H,d,J= 12Hz), 3.68 (1H,d,J=12Hz), 3.43-3.66 (2H,m), 4.11 (1H,s), 6.90-7.10 (1H,m) Reference Example 4 Preparation of Benzyl 3-[N-(5,5-Dimethyl-2-phenyl-1,3-dioxane-4-carbonyl)amino]propionate A solution of 3.09 g of benzyl 3-[N-(2,4-dihydroxy-3,3,-dimethyl-1-oxo)amino]propionate, 6.90 g of benzaldehyde dimethylacetal, and 0.19 g of p-toluenesulfonic acid in 100 ml of benzene was refluxed for 2 hours with removing water produced by azeotropy. After completion of the reaction, the reaction mixture was washed with saturated aqueous sodium bicarbonate solution, with water and then with saturated saline, and dried over anhydrous sodium sulfate. After removing the solvent by evapoation, the residue obtained was purified by silica gel column chromatography to obtain 3.18 g of the objective compound (yield: 80%). Property: Oily IR(cm⁻¹, neat): νNH 3456, νCO 1740, 1676 Mass Spectrometric Analysis: Molecular formula C₁₉H₂₇NO₅ Calculated 397.1889 Found 397.1882 NMR(δ, CDCl₃): 1.08 (3H,s), 1.10 (3H,s), 2.62 (2H,t,J=6Hz), 3.68 (1H,d,J=11Hz), 3.45-3.64 (2H,m), 3.72 (1H,d,J=1Hz), 4.09 (1H,s), 5.10(2H,s), 5.51 (1H,s), 6.92-7.04 (1H,m), 7.38-7.52 (10H,m) Reference Example 5 Preparation of Benzyl 3-[N-(3,3-Dimethyl-1,5-dioxaspiro[5,5]-dodecane-2-carbonyl)amino)propionate Benzyl 3-[N-(2,4-dihydroxy-3,3,-dimethyl-1-oxo)amino]-propionate (3.09 g and 1.47 g of cyclohexanone were reacted in the same manner as in Reference Example 4 to obtain 3.07 g of the objected compound (yield: 79%). Property: Oily IR(cm⁻¹, neat): νCO 1738, 1680 Mass Spectrometric Analysis: Molecular formula C₂₂H₃₁NO₅ Calculated 389.2202 Found 389.2214 NMR(δ, CDCl₃): 0.95 (3H,s), 1.03 (3H,s), 1.32-1.50 (4H,m), 1.54-1.70 (4H,m), 1.78-1.90 (2H,m), 2.62 (2H,t,J=7Hz), 3.25 (1H,d,J=12Hz), 3.46-3.66 (2H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 5.14 (2H,s), 7.00-7.10 (1H,m), 7.30-7.42 (5H,m) Reference Example 6 Preparation of 3-[N-(5,5-Dimethyl-2-phenyl-1,3-dioxane-4-carbonyl)amino]propionic Acid Benzyl 3-[N-(5,5-Dimethyl-2-phenyl-1,3-dioxane-4-carbonyl)amino]propionate (1.0 g) was reacted in the same manner as in Reference Example 3 to obtain 0.77 g of the objctived compound (yield: quantitiative). Property: Oily IR(cm⁻¹, neat): νNH 3420, νCO 1732, 1636 Mass Spectrometric Analysis: Molecular formula C₁₆H₂₁NO₅ Calculated 307.1419 Found 307.1423 NMR(δ, CDCl₃): 1.11 (3H,s), 2.62 (2H,t,J=7Hz), 3.28 (1H,d,J= 12Hz), 3.44-3.64 (2H,m), 3.68 (1H,d,J=1Hz), 3.73 (1H,d,J=11Hz), 4.12 (1H,s), 5.51 (1H,s), 7.00-7.10 (1H,m), 7.38-7.45 (3H,m), 7.45-7.52 (2H,m) Referenc Example 7 Preparation of 3-[N-(3,3-Dimethyl-1,5-dioxaspiro[5,5)dodecane-2-carbonyl)amino]propionic Acid In a solution of .95 g of benzyl 3-[N-(3,3-dimethyl-1,5-dioxaspiro[5,5)-dodecane-2-carbonyl)amino]propionate in 20 ml of methanol was suspended 20 mg of 10% palladium-on-carbon, and the suspension was stirred at room temperature for one night under hydrogen gas atmosphere. After completion of the reaction, insoluble matter was filtered. Removal of the solvent by evaporation afforded 1.50 g of the objective compound. Property: Oily IR(cm⁻¹, neat): νCO 1728, 1670 Mass Spectrometric Analysis: Molecular formula C₁₅H₂₅NO₅ Calculated 299.1732 Found 299.1718 NMR(δ, CDCl₃): 0.99 (3H,s), 1.04 (3H,s), 1.32-1.51 (4H,m), 1.54-1.94 (7H,m), 2.64 (2H,t,J=6Hz), 3.26 (1H,d,J=12Hz), 3.71 (1H,d,J=12Hz), 3.46-3.64 (2H,m), 4.12 (1H,s), 7.08-7.14 (1H,m) Reference Example 8 Preparation of 3-[N-(3,3-Dimethyl-1,5-dioxaspiro[5,5]dodecane-2-carbonyl)amino]propionic Acid Acetic anhydride (10.2 g) was added to a suspension 4.47 g of calcium pantothenate in 20 ml of pyridine, and the mixture was stirred for one night. After completion of the reaction, the reaction mixture was poured in ice water. After stirring for 2 hours, 1N Hydrochloric acid was added to the reaction mixture to adjust pH to a value of about 2, followed by extraction with ethyl acetate. The organic layer was washed with saturated saline, and dried over anhydrous sodium sulfate. After removal of the solvent, 4.19 g of the objective compound was obtained as a residue (yield: 69%). Property: Oily Reference Example 9 Preparation of 4-Nitropheny 3-[N-(2,4-diacetoxy -3,3-dimethyl-1-oxobutyl)amino]propionate Dicyclohexylcarbodiimide (15.5 g) was added to a solution of 22.6 g of 3-[N-(2,4-diacetoxy-3,3-dimethyl -1-oxobutyl)amino]propionic acid and 10.4 g of p-nitrophenol in 500 ml of tetrahydrofuran, and the mixture was stired for one night. After completion of the reaction, insoluble matter was removed and the solvent was distilled off under reduced pressure. The residue was dissolved in ethyl acetate. The resulting solution was washed with saturated aqueous sodium bicarbonate solution, with water and then with saturated saline, and dried over anhydrous sodium sulfate. After removing the solvent by evaporation, 10.2 g of the objectived compound was obtained as a residue (yield: 32%). Porperty: Oily IR(cm⁻¹, neat): νNH 3456, νCO 1740, 1676 Mass Spectrometric Analysis: Molecular formula C₁₉H₂₄N₂O₉ Calculated 424.1481 Found 424.1467 NMR(δ, CDCl₃): 1.04 (3H,s), 1.08 (3H,s), 2.06 (3H,s), 2.10 (3H,s), 2.84-2.91 (2H,m), 3.50-3.76 (2H,m), 3.86 (1H,d,J=11Hz), 6.06 (1H,d,J= 11Hz), 4.93 (1H,s), 6.50-6.66 (1H,m), 7.29 (2H,d,J,7Hz), 8.28 (2H,d,7Hz) Reference Example 10 Preparation of Benzyl 2-[N-(2,4-Dihydroxy-3,3-dimethylbutanoyl)-amino]acetate A solution of 13.0 g of pantolactone, 8.3 g of glycine and potassium hydroxide (final concentration: 85%) in 100 ml of methanol was heated under reflux for 3 hours. The solvent was distilled off under reduced pressure. After drying, the residue was dissolved in 150 ml of dimethylformamide, and 18.8 g of benzyl bromide was added to the resulting solution, followed by stirring at room temperature for 20 hours. The reaction mixture was distilled under reduced pressure, and the residue obtained was dissolved in water and extracted with ethyl acetate. The organic layer was washed with water and then with saturate saline, and dried over anhydrous sodium sulfate. The residue obtained was purified by silica gel column chromatography to obtain 12.8 g of the objective compound (yield: 43%). NMR(δ, CDCl₃) : 0.95 (3H,s), 1.60 (3H,s), 2.73 (2H,brs), 3.51 (1H,d,J=11Hz), 3.56 (1H,d,J=11Hz), 4.03-4.21 (2H,m), 4.09 (1H,s), 5.19 (2H,s), 7.23-7.28 (1H,m), 7.33-7.42 (5H,m) Reference Example 11 Preparation of o-Oleoylaminoaniline N,N′-Dicyclohexylcarbodiimide (2.27 g) was added to a solution of 2.82 g of oleic acid and 1.62 g of o-phenylenediamine in 50 ml of methylene chloride with stirring under ice cooling. The mixture was stirred at room temperature for one night. After completion of the reaction insoluble matter was filtered, followed by removal of the solvent by evaporation. The residue obtained was purified by silica gel column chromatography to obtain 2.84 g of the objective compound (yield: 76%). Property: Oily IR(cm⁻¹, neat): νNH 3284, νCO 1646 Mass Spectrometric Analysis: Molecular formula : C₂₄H₄₀N₂O Calculated 372.3140 Found 372.3129 0.88 (3H,t,J=7Hz), 1.18-1.45 (20H,m), 1.65-1.81 (2H,m), 1,90-2.09 (4H,m), 2.41 (2H,t,J=7Hz), 3.84 (2H,brs), 5.28-5.43 (2H,m), 6.76-6.83 (2H,m), 7.02-7.13 (2H,m), 7.17 (1H,d,J=8Hz) Reference Example 12 Preparation of m-Oleoylaminoaniline Oleic acid (2.82 g) and m-phenylenediamine (1.62 g) were reacted in the same manner as Reference Example 11 to obtain 2.60 g of the objective compound (yield: 70%). Property: Oily IR(cm⁻¹, neat): νNH 3324, νCO 1658 Mass Spectrometric Analysis: Molecular formula C₂₄H₄₀N₂O Calculated 372.3140 Found 372.3143 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.20-1.42 (20H,m), 1.64-1.78 (2H,m), 1.90-2.09 (4H,m), 2.32 (2H,t,J=7Hz), 3.70 (2H,brs), 5.29-5.40 (2H,m), 6.42 (1H,d,J=8Hz), 6.62 (1H,d,J=8Hz), 7.00 (1H,brs), 7.21 (1H,s) Reference Example 13 Preparation of p-Oleoylaminoaniline Oleic acid (2.82 g) and p-phenylenediamine (1.62 g) were reacted in the same manner as in Reference Example 11 to obtain 2.85 g of the objective compound (yield: 77%). Property: Oily IR(cm⁻¹, neat): νNH 3294, νCO 1656 Mass Spectrometric Analysis: Molecular formula C₂₄H₄₀N₂O Calculated 372.3140 Found 372.3138 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.18-1.42 (20H,m), 1.64-1.77 (2H,m), 1.92-2.09 (4H,m), 2.31 (2H,t,J=7Hz), 3.60 (2H,brs), 5.29-5.40 (2H,m), 6.65 (2H,d,J= 9Hz), 6.92 (1H,brs), 7.26 (2H,d,J=9Hz) Reference Example 14 Preparation of p-Oleoylaminophenol Oleic acid (2.82 g) and p-aminophnol (1.64 g) were reacted in the same manner as in Reference Example 11 to obtain 1.57 g of the objective compound (yield: 42%). Property: Oily IR(cm⁻¹, neat): νNH , νCO 1646, Mass Spectrometric Analysis: Molecular formula C₂₄H₃₉NO₂ Calculated 373.2980 Found 373.2988 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.20-1.42 (20H,m), 1.65-1.79 (2H,m), 1.89-2.09 (4H,m), 2.31 (2H,t,J=7Hz), 5.28-5.41 (2H,m), 6.77 (2H,d,9Hz), 7.04 (1H,brs), 7.32 (2H,d,J=9Hz) Reference Example 15 Preparation of 2,4-Diacetoxy-N-[3-[(4-hydroxyphenyl)amino]-3-oxopropyl]-3,3-dimethylbutanamide 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (2.30 g) was added to a solution of 3.03 g of 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid and 2.18 g of p-aminophenol in 50 ml of methylene chloride, and the mixture was stirred for one night. After completion of the reaction, the reaction mixture was washed with water, and dried over anhydrous sodium sulfate. After removing the solvent by evaporation, the residue obtained was purified by silica gel column chromatography to obtain 1.92 g of the objective compound was obtained as a residue (yield: 50%). Property: Oily IR(cm⁻¹, neat): νCO 1750, 1660 Mass Spectrometric Analysis: Molecular formula C₁₉H₂₆N₂O₇ Calculated 394.1740 Found 394.1746 NMR(δ, CDCl₃): 1.02 (3H,s), 1.06 (3H,s), 2.05 (3H,s), 2.07 (3H,s), 2.55 (2H,t,J=6Hz), 3.50-3.71 (2H,m), 3.84 (1H,d,J=12Hz), 4.03 (1H,d,J=12Hz), 4.90 (1H,s), 6.74-6.83 (1H,m), 6.79 (2H,d,J= 8Hz), 7.35 (2H,d,J=8Hz), 7.47 (1H,brs) Reference Example 16 Preparation of S-4-Aminophenyl 3-[N-(2,4,-Diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanethioate 3-[N-(2,4-Diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid (1.52 g) and 1.00 g of p-aminothiophenol were reacted in the same manner as in Reference Example 11 to obtain 0.335 mg of the objective compound (yield: 16%) Property: Oily Mass Spectrometric Analysis: Molecular formula C₁₉H₂₆N₂O₆S Calculated 410.1511 Found 410.1520 NMR(δ, CDCl₃): 1.01 (3H,s), 1.06 (3H,s), 2.06 (3H,s), 2.11 (3H,s), 2.87 (2H,t,J=6Hz), 3.44-3.69 (2H,m), 3.81 (1H,d,J=11Hz), 4.03 (1H,d,J=11Hz), 4.97 (1H,s), 6.50 (1H,t,J=6Hz), 6.92 (2H,d,J= 8Hz), 7.24 (2H,d,J=8Hz) Reference Example 17 Preparation of S-4-Aminophenyl 9-Octadecenethioate Oleic acid (2.82 g) and 1.88 g of p-aminothiophenol were reacted in the same manner as in Reference Example 11 to obtain 2.86 g of the objective compound (yield: 74%). Property: Oily IR(cm⁻¹, neat): νNH 3500, νCO 1698 Mass Spectrometric Analysis: Molecular formula C₂₄H₃₉NOS Calculated 389.2752 Found 389.2754 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.19-1.41 (20H,m), 1.62-1.75 (2H,m), 1.91-2.09 (4H,m), 2.60 (2H,t,J=7Hz), 3.83 (2H,brs), 5.29-5.41 (2H,m), 6.68 (2H,d,8Hz), 7.16 (2H,d,J=8Hz) Reference Example 18 Preparation of N-(4-Hydroxyphenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (1.04 g) and 0.665 g of p-aminophenol were reacted in the same manner as in Reference Example 15 to obtain 1.37 g of the objective compound (yield: 98%). Property: Oily IR(cm⁻¹, neat): νCO 1660 Mass Spectrometric Analysis: Molecular formula C₁₈H₂₆N₂O₅ Calculated 350.1841 Found 350.1846 NMR(δ, CDCl₃): 0.97 (3H,s), 1.04 (3H,s), 1.41 (3H,s), 1.45 (3H,s), 2.26 (2H,t,J=6Hz), 3.50-3.72 (2H,m), 3.28 (1H,d,J=12Hz), 3.68 (1H,d,J=12Hz), 4.10 (1H,s), 6.78 (2H,d,J=8Hz), 7.13 (1H,d,J =6Hz), 7.32 (2H,d,J=8Hz), 8.02 (1H,s) Reference Example 19 Preparation of N-(4-Hydroxyphenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (1.30 g) and 1.00 g of p-aminothiophenol were reacted in the same manner as in Reference Example 15 to obtain 0.28 g of the objective compound (yield: 15%). IR(cm⁻¹, neat): νCO 1692 Mass Spectrometric Analysis: Molecular formula C₁₈H₂₆N₂O₄S Calculated 366.1613 Found 366.1608 NMR(δ, CDCl₃): 1.00 (3H,s), 1.04 (3H,s), 1.42 (3H,s), 1.45 (3H,s), 2.78-2.97 (2H,m), 3.29 (1H,d,J= 11Hz), 3.45-3.71 (2H,m), 3.69 (1H,d,J=11Hz), 4.08 (1H,s), 6.69 (2H,d,J=8Hz), 6.84-6.92 (1H,m), 7.15 (2H,d,J=8Hz) Reference Example 20 Preparation of p-Oleoylaminophenol Sodium carbonate (1.27 g) was added to a solution of 1.09 g of 2-aminophenol in a mixed solvent composed of 20 ml of ethyl acetate and 20 ml of water. To the resulting mixture was added a solution of 3.01 g of oleoyl chloride in 10 ml of ethyl acetate portion-wise with stirring under ice cooling. The stirring was continued for additional 2 hours. After completion of the reaction, the organic layer was separated, washed with water and then with saturated saline, and dried over anhydrous sodium sulfate. After removal of the solvent by evaporation, the residue obtained was purified by silica gel column chromatography to obtain 3.40 g of the objective compound (yield: 91%). Property: Oily IR(cm⁻¹, neat): νCO 1646 Mass Spectrometric Analysis: Molecular formula C₂₄H₃₉NO₂ Calculated 373.2980 Found 373.2988 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.18-1.45 (20H,m), 1.66-1.80 (2H,m), 1.92-2.10 (4H,m), 2.45 (2H,d,J=7Hz), 5.28-5.40 (2H,m), 6.85 (2H,d,8Hz), 6.97 (1H,d,J=8Hz), 7.02 (1H,d,J= 8Hz), 7.13 (1H,d,J=8Hz), 7.45 (1H,brs) Reference Example 21 Preparation of N-(2-Hydroxyphenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (0.26 g) and 0.13 g of o-aminophenol were reacted in the same manner as in Reference Example 15 to obtain 0.34 g of the objective compound (yield: 98%). Property: Oily IR(cm⁻¹, neat): νCO 1660 Mass Spectrometric Analysis: Molecular formula C₁₈H₂₆N₂O₅ Calculated 350.1841 Found 350.1843 NMR(δ, CDCl₃): 0.97 (3H,s), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 2.77 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.59-3.77 (2H,m), 4.11 (1H,s), 6.86 (1H,t,J= 8Hz), 7.01 (1H,d,J=8Hz), 7.08-7.22 (3H,m) 8.80 (1H,s) Reference Example 2 2 Preparation of N-(2-aminophenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (3.89 g) and 2.16 g of o-phenylenediamine were reacted in the same manner as in Reference Example 15 to obtain 2.48 g of the objective compound (yield: 47%). Property: Oily IR(cm⁻¹, neat): νCO 1660 Mass Spectrometric Analysis: Molecular formula C₁₈H₂₇N₃O₄ Calculated 349.2001 Found 349.1993 NMR(δ, CDCl₃): 0.99 (3H,s), 1.03 (3H,s), 1.42 (3H,s), 1.45 (3H,s), 2.67 (2H,t,J=6Hz), 3.59-3.70 2H,m), 3.28 (1H,d,J=12Hz), 3.68 (1H,d,J=12Hz), 4.10 (1H,s), 6.72.-6.82 (2H,m), 7.03-7.16 2H,m), 7.20 (1H,d,J=8Hz), 7.87 (1H,s) Reference Example 23 Preparation of m-Linoleoylaminoaniline Linolic acid (0.841 g) and 0.541 g of o-phenylenediamine were reacted in the same manner as in Reference Example 11 to obtain 0.79 g of the objective compound (yield: 62%). Property: Oily IR(cm⁻¹, neat): νCO 1646 Mass Spectrometric Analysis: Molecular formula C₂₄H₃₈N₂O Calculated 370.2984 Found 370.2981 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 1.22-1.43 (14H,m), 1.63-1.88 (2H,m), 1.98-2.11 (4H,m), 2.32 (2H,t,J=7Hz), 2.77 (2H,t,J=6Hz), 5.28.-5.46 (4H,m), 6.47 (1H,d,J=8Hz), 6.69 (1H,d,8Hz), 7.07 (1H,t,J= 8Hz), 7.14 (1H,s), 7.24 (1H,s) Reference Example 24 Preparation of p-Lauroylaminoaniline p-Phenylenediamine (342 mg) and 219 mg of 1-lauroyl chloride were reacted in the same manner as in Reference Example 20 to obtain 250 mg of the objective compound (yield: 86%). Property: Oily IR(cm⁻¹, neat): νCO 1651 Mass Spectrometric Analysis: Molecular formula C₁₈H₃₀N₂O Calculated 290.2358 Found 290.2362 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.17-1.42 (16H,m), 1.63-1.78 (2H,m), 2.31 (2H,t,J=7Hz), 3.581 (2H,bris), 6.64 (2H,d,z), 6.98 (1H,brs), 7.26 (2H,d,J= 9Hz) Reference Example 25 Preparation of p-Linolenoylaminoaniline Linolenic acid (835 mg) and 546 mg of p-aminophenol were reacted in the same manner as in Reference Example 11 to obtain 1.03 g of the objective compound (yield: 55%). Porperty: Oily IR(cm⁻¹, neat): νCO 1646 Mass Spectrometric Analysis: Molecular formula C₂₄H₃₅NO₂ Calculated 369.2667 Found 369.2672 NMR(δ, CDCl₃): 0.97 (3H,t,J=7Hz), 1.19-1.44 (8H,m), 1.56-1.77 (2H,m), 1.98-2.12 (4H,m), 2.33 (2H,t,J=7Hz), 2.71-2.88 (4H,m), 5.26-5.45 (6H,m), 6.77 (2H,d,9Hz), 7.05 (1H,s), 7.31 (2H,d,J=9Hz) Reference Example 26 Preparation of trans-2-(Oleoylamino)cyclohexylamine Sodium methoxide (0.60 g) was added to a solution of 1.14 g of trans-1,2-diaminocyclohexane and 2.96 g of methyl oleate in 15 ml of benzene, and the mixture was heated under reflux for 20 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was dissolved in ethyl acetate-water. The organic layer was washed with saturated saline, and dried over anhydrous sodium sulfate. After drying it over anhydrous sodium sulfate, the residue obtained was purified by silica gel column chromatography to obtain 2.54 g of the objective compound (yield: 68%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₄H₄₆N₂O Calculated 378.3610 Found 378.3611 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.12-1.48 (24H,m), 1.53-1.79 (4H,m), 1.91 (6H,m), 2.18-2.35 (2H,m), 2.52-2.95 (3H,m), 3.62-3.78 (1H,m), 5.28-5.40 (2H,m), 6.08-6.20 (1H,m) Reference Example 27 Preparation of (S,S)-2-(Oleoylamino)cyclohexylamine (S,S)-1,2-Diaminocyclohexane (1.14 g) and 2.96 g of methyl oleate were reacted in the same manner as in Reference Example 26 to obtain 2.41 g of the objective compound (yield: 65%) Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₄H₄₆N₂O Calculated 378.3610 Found 378.3612 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.12-1.48 (24H,m), 1.53-1.79 (4H,m), 1.91 (6H,m), 2.18-2.35 (2H,m), 2.52-2.95 (3H,m), 3.62-3.78 (1H,m), 5.28-5.40 (2H,m), 6.08-6.20 (1H,m) Reference Example 28 Preparation of (1R,2R)-2-(Oleoylamino)cyclohexanol (1R,2R)-2-Aminocyclohexanol (1.15 g) and 3.0 g of oleyl chloride were reacted in the same manner as in Reference Example 20 to obtain 3.74 g of the objective comound (yield: 99%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₄H₄₅NO₂ Calculated 379.3450 Found 379.3453 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.10-1.42 (24H,m), 1.57-1.78 (4H,m), 1.89-2.10 (6H,m), 2.22 (2H,t,J=7Hz), 3.32 (1H,ddd,J=11Hz,11Hz,5Hz), 3.58-3.70 (1H,m), 5.28-5.50 (3H,m) Reference Example 29 Preparation of (1S,2S)-2-(Oleoylamino)cyclohexanol (1S,2S)-2-Aminocyclohexanol (1.15 g) and 3.0 g of oleyl chloride were reacted in the same manner as in Reference Example 20 to obtain 3.76 g of the objective compound (yield: 99%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₄H₄₅NO₂ Calculated 379.3450 Found 379.3453 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.10-1.42 (24H,m), 1.57-1.78 (4H,m), 1.89-2.10 (6H,m), 2.22 (2H,t,J=7Hz), 3.32 (1H,ddd,J=11Hz,11Hz, 5Hz), 3.58-3.70 (1H,m), 5.28-5.50 (3H,m) Reference Example 30 Preparation of (1R,2R)-2-(Stearoylamino)cyclohexanol (1R,2R)-2-Aminocyclohexanol (1.15 g) and 3.02 g of stearyl chloride were reacted in the same manner as in Reference Example 20 to obtain 3.0 g of the objective compound (yield: 100%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₄H₄₇NO₂ Calculated 381.3606 Found 381.3611 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.11-1.41 (32H,m), 1.57-1.78 (4H,m), 1.89-2.11 (2H,m), 2.22 (2H,t,J=7Hz), 3.31 (1H,ddd,J=11Hz,11Hz, 5Hz), 3.58-3.70 (1H,m), 5.42-5.51 (1H,m) Reference Example 31 Preparation of (1S,2S)-2-(Linoleoylamino)cyclohexanol (1S,2S)-2-Aminocyclohexanol (1.15 g) and 2.98 g of linolyl chloride were reacted in the same manner as in Reference Example 20 to obtain 3.76 g of the objective compound (yield: 99%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₄H₄₃NO₂ Calculated 377.3293 Found 377.3299 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 1.12-1.41 (18H,m), 1.58-1.77 (4H,m), 1.89-2.18 (6H,m), 2.22 (2H,t,J=8Hz), 2.77 (2H,t,J=6Hz), 3.31 (2H,ddd,J=11Hz,11Hz, 5Hz), 3.59-3.70 (1H,m), 5.29-5.47 (5H,m) Reference Example 32 Preparation of (1S,2S)-2-(N-Benzyl-N-hexylcarbamoyl)aminocyclohexanol A solution of 470 mg of phenyl chlorocarbonate in 5 ml of ethyl acetate was added portion-wise to a solution of 345 mg of (1S,2S)-2-aminocyclohexanol and 424 mg of sodium carbonate in a mixed solvent composed of 10 ml of ethyl acetate and 10 ml of water with stirring under ice cooling. After completion of the addition, the resulting mixture was stirred for additional 2 hours. After completion of the reaction, the aqueous layer was separated and extracted with ethyl acetate. The extract was combined with the organic layer, which was then washed with saturated saline. After drying it over anhydrous sodium sulfate, the combined organic layer was distilled to remove the solvent. Then, N-benzylhexylamine (1.15 g) was added to the residue obtained, and the mixture was stirred at 100°C for 1 hour. After completion of the reaction, the residue obtained was purified by silica gel column chromatography to obtain 866 mg of the objective compound (yield: 87%). NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.96-2.08 (16H,m), 3.15-3.54 (4H,m), 4.25 (1H,d,J=6Hz), 4.47 (2H,s), 4.67 (1H,d,J=3Hz), 7.20-7.41 (5H,m) Reference Example 33 Preparation of (S)-1-(t-Butoxycarbonel)-2-(oleoylaminomethyl)-pyrrolidine (S)-2-Aminomethyl-1-(t-butoxycarbonyl)pyrrolidine (607 mg) and 903 mg of oleyl chloride were reacted in the same manner as in Reference Example 20 to obtain 1.16 g of the objective compound (yield: 83%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₈H₅₂N₂O₃ Calculated 464.3977 Found 464.3969 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.16-1.37 (20H,m), 1.16-1.37 (20H,m), 1.48 (9H,s), 1.53-2.09 (10H,m), 2.17 (2H,t,J=7Hz), 3.13-3.45 (4H,m), 3.97-4.10 (1H,m), 5.28-5.41 (2H,m), 7.42 (1H,brs) Reference Example 34 Preparation of (R)-1-(t-Butoxycarbonel)-2-(oleoylaminomethyl)-pyrrolidine (R)-2-Aminomethyl-1-(t-butoxycarbonyl)pyrrolidine (401 mg) and 600 mg of oleyl chloride were reacted in the same manner as in Reference Example 20 to obtain 816 mg of the objective compound (yield: 88%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₈H₅₂N₂O₃ Calculated 464.3977 Found 464.3969 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.16-1.37 (20H,m), 1.48 (9H,s), 1.53-2.09 (10H,m), 2.17 (2H,t,J= 7Hz), 3.13-3.45 (4H,m), 3.97-4.10 (1H,m), 5.28-5.41 (2H,m), 7.42 (1H,brs) Reference Example 35 (A) Preparation of (R)-1-(t-Butoxycarbonel)-2-(oleoylaminomethyl)pyrrolidine 3-Amino-1-(t-butoxycarbonyl)piperidine (400 mg) and 600 mg of oleyl chloride were reacted in the same manner as in Reference Example 20 to obtain 742 mg of the ojective compound (yield: 85%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₈H₅₂N₂O₃ Calculated 464.3977 Found 464.3984 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.17-1.41 (20H,m), 1.49-1.84 (6H,m), 1.91-2.09 (4H,m), 2.15 (2H,t,J=7Hz), 2.15 (2H,t,J=7Hz), 3.22-3.53 (4H,m), 3.92-4.03 (1H,m), 5.28-5.41 (2H,m), 5.47-5.62 (1H,m) (B) Preparation of 3-Oleoylaminopiperidine A solution 464 mg of 1-(t-butoxycarbonyl)-3-(oleoylamino)piperidine in 6 ml of 50% trifluoroacetic acid-methylene chloride was stirred at room tempeature for 1 hour. After completion of the reaction, the solvent was distilled off. The residue obtained was dissolved in 20 ml of ethyl acetate. After adding saturated aqueous sodium carbonate solution to the solution to neutralize it, the organic layer was separated. The organic layer was washed with saturated saline, and dried over anhydrous sodium sulfate, followed by removal of the solvent therefrom by evaporation. The residue obtained was purified by silica gel column chromatography to obtain 332 g of the objective compound (yield: 91%). Mass Spectrometric Analysis: Molecular formula C₂₃H₄₄N₂O Calculated 364.3453 Found 364.3451 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.17-1.39 (20H,m), 1.54-1.86 (6H,m), 1.90-2.08 (4H,m), 2.20 (2H,t,J=7Hz), 2.70-3.07 (4H,m), 4.00-4.07 (1H,m), 5.28-5.44 (2H,m), 6.49-6.63 (1H,m) Reference Example 36 (A) Preparation of 1-(t-Butoxycarbonel)-3-[3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl]aminopiperidine 3-Amino-1-(t-butoxycarbonyl)piperidine (681 mg) and 0.88 g of 3-[N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Reference Example 25 to obtain 1.38 g of the objective compound (yield: 97%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₂H₃₉N₃O⁶ Calculated 441.2838 Found 441.2861 NMR(δ, CDCl₃): 0.97-0.98 (3H,m), 1.05 (3H,s), 1.42-1.43 (3H,m), 1.46 (10H,s), 2.43 (2H,t,J=7Hz), 3.05-3.27 (2H,m), 3.28 (1H,d,J=12Hz), 3.36-3.67 (5H,m), 3.69 (1H,d,J=12Hz), 3.87-4.00 (1H,m), 4.07-4.08 (1H,m), 5.93-6.02 (1H,m), 6.99-7.08 (1H,m) Reference Example 37 Preparation of 1-Oleoyl-4-hydroxypiperidine 4-Hydroxypiperidine (2.02 g) and oleyl chloride (6 g) were reacted in the same manner as in Reference Example 20 to obtain 5.8 g of the objective compound (yield: 79%). Property: Oily IR(cm⁻¹, neat): νNH 3428, νCO 1628 Mass Spectrometric Analysis: Molecular formula C₂₃H₄₃NO₂ Calculated 365.3293 Found 365.3309 NMR(δ, CDCl₃): 1.88 (3H,t,J=7Hz), 1.22-1.40 (2H,s), 1.42-1.68 (4H,s), 1.82-2.06 (6H,m), 2.33 (2H,t,J=7Hz), 3.10-3.28 (2H,m), 3.68-3.82 (1H,m), 3.88-3.98 (1H,m), 4.02-4.18 (1H,m), 5.30-5.42 (2H,m) Reference Example 38 Preparation of 1-Oleoyl-3-hydroxypiperidine 3-Hydroxypiperidine (1.38 g) and oleyl chloride (3.01 g) were reacted in the same manner as in Reference Example 20 to obtain 3.33 g of the objective compound (yield: 91%). Property: Oily IR(cm⁻¹, neat): νOH 3428, νCO 1628 Mass Spectrometric Analysis: Molecular formula C₂₃H₄₃NO₂ Calculated 365.3293 Found 365.3286 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.20-1.39 (20H,m), 1.40-2.09 (10H,m), 2.32 (2H,t,J=7Hz), 3.18-3.35 (2H,m), 3.67-3.84 (5H,m), 5.28-5.40 (2H,m) Reference Example 39 Preparation of (R)-1-Oleoyl-2-pyrrolidinemethanol D-2-pyrrolidinemethanol (405 mg) and oleyl chloride (1.20 g) were reacted in the same manner as in Reference Example 20 to obtain 1.46 g of the ojective compound (yield: 100%). Property: Oily IR(cm⁻¹, neat): νOH 3430, νCO 1625 Mass Spectrometric Analysis: Molecular formula C₂₃H₄₃NO₂ Calculated 365.3293 Found 365.3290 NMR(δ, CDCl₃): 0.83 (3H,t,J=7Hz), 1.18-1.48 (20H,m), 1.50-1.71 (3H,m), 1.79-2.10 (7H,m), 2.30 (2H,t,J=7Hz), 3.41-3.69 (4H,m), 4.18-4.27 (1H,m), 5.29-5.42 (2H,m) Reference Example 40 Preparation of (S)-1-Oleoyl-2-pyrrolidinemethanol L-2-pyrrolidinemethanol (506 mg) and oleyl chloride (1.50 g) were reacted in the same manner as in Reference Example 20 to obtain 1.73 g of the ojective compound (yield: 100%). Property: Oily IR(cm⁻¹, neat): νOH 3430, νCO 1625 Mass Spectrometric Analysis: Molecular formula C₂₃H₄₃NO₂ Calculated 365.3293 Found 365.3288 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.88-1.48 (20H,m), 1.50-1.71 (3H,m), 1.79-2.10 (2H,t,J=7Hz), 2.30 (2H,t,J= 7Hz), 3.41-3.69 (4H,m), 4.18-4.27 (1H,m), 5.29-5.42 (2H,m) Reference Example 41 Preparation of (S)-1-Stearoyl-2-pyrrolidinemethanol L-2-pyrrolidinemethanol (101 mg) and stearyl chloride (303 mg) were reacted in the same manner as in Reference Example 20 to obtain 366 mg of the ojective compound (yield: 100%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₃H₄₅NO₂ Calculated 367.3450 Found 367.3471 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.17-1.47 (28H,m), 1.52-1.69 (3H,m), 1.79-2.11 (3H,m), 2.30 (2H,t,J=7Hz), 3.41-3.70 (4H,m), 4.17-4.28 (1H,m) Reference Example 42 Preparation of (S)-1-Linoloyl-2-pyrrolidinemethanol L-2-pyrrolidinemethanol (101 mg) and linolyl chloride (315 mg) were reacted in the same manner as in Reference Example 20 to obtain 360 mg of the ojective compound (yield: 100%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₃H₄₁NO₂ Calculated 363.3137 Found 363.3152 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 1.21-1.44 (14H,m), 1.52-1.76 (3H,m), 1.77-2.11 (7H,m), 2.30 (2H,t,J=7Hz), 2.77 (2H,t,J=6Hz), 3.42-3.70 (4H,m), 4.18-4.28 (1H,m), 5.28-5.44 (4H,m) Reference Example 43 (A) Preparation of (S)-1-Benzyloxycarbonyl-2-(1-oxo-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propyl]-aminomethylpyrrolidine (S)-2-Aminomethyl-1-benzyloxycarbonylpyrrolidine (234 mg) and 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]-propionic acid (259 mg) were reacted in the same manner as in Reference Example 25 to obtain 424 mg of the ojective compound (yield: 89%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₅H₃₇N₃O₆ Calculated 475.2682 Found 475.2701 NMR(δ, CDCl₃): 0.98 (3H,s), 1.04 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 1.62-2.13 (4H,m),2.30-2.44 (2H,m), 3.16-3.62 (4H,m), 3.27 (1H,d,J=12Hz), 3.68 (1H,d,J=12Hz), 3.92-4.09 (1H,m), 4.07 (1H,s), 5.07-5.24 (2H,m), 7.05-7.16 (1H,m), 7.17-7.25 (1H,m), 7.28-7.48 (5H,m) (B) Preparation of (S)-2-[1-Oxo-3-(2,2,5,5,-tetramethyl-1,3-dioxane-4-carbonyl)amino]propyl]aminomethylpyrrolidine (S)-1-Benzyloxycarbonyl-2-[1-Oxo-3-(2,2,5,5,-tetramethyl-1,3-dioxane-4-carbonylaminopropyl]aminomethylpyrrolidine (424 mg) was reacted in the same manner as in Reference Example 7 to obtain 298 mg of the ojective compound (yield: 98%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₁₇H₃₁N₃O₄ Calculated 341.2314 Found 341.2327 NMR(δ, CDCl₃): 1.00 (3H,s), 1.01 (3H,s), 1.45 (3H,s), 1.47 (3H,s), 1.58-1.78 (1H,m), 1.82-2.15 (3H,m), 2.36-2.56 (2H,m), 3.07-3.85 (9H,m), 4.12 (1H,s) 7.09 (1H,t,J=6Hz), 7.48 (1H,t,J=6Hz) Reference Example 44 Preparation of (R)-1-Benzyloxycarbonyl-2-[1-oxo-3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propyl]aminomethylpyrrolidine (R)-2-Aminomethyl-1-benzyloxycarbonylpyrrolidine (750 mg) and 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (829 mg) were Example reacted in the same manner as in Reference Example 25 to obtain 1.10 g of the ojective compound (yield: 72%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₅H₃₇N₃O₆ Calculated 475.2682 Found 475.2701 NMR(δ, CDCl₃): 0.96 (3H,s), 1.03 (3H,s), 1.41 (3H,s), 1.46 (3H,s), 1.65-2.17 (4H,m), 2.33 (2H,t,J=6Hz), 3.14-3.32 (1H,m), 3.27 (1H,d,J=12Hz), 3.35-3.63 (5H,m), 3.68 (1H,d,J=12Hz), 3.93-4.09 (1H,s) 4.07 (1H,s), 5.07-5.28 (2H,m), 7.01-7.16 (1H,m), 7.20-7.44 (6H,m) Reference Example 45 Preparation of 1-Oleoylpiperazine A solution of 3.0 g of oleyl chloride in 10 mg of methylene chloride was added portion-wise to a solution of 4.3 g of piperazine in 30 ml of methylene chloride with stirring under ice cooling. After stirring the mixture in situ for additional 2 hours, 10 ml of water was added to the reaction mixture to separate the organic layer. The organic layer was further washed with water and dried over anhydrous sodium sulfate, followed by removal of the solvent by evaporation. The residue obtained was purified by silica gel column chromatography to obtain 2.68 g of the objective compound (yield: 76%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₂H₄₂N₂O Calculated 350.3297 Found 350.3308 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.18-1.39 (20H,m), 1.62-1.78 (2H,m), 1.91-2.07 (4H,m), 2.31 (2H,t,J=7Hz), 2.90-3.00 (4H,m), 3.62-3.73 (4H,m), 3.62-3.73 (4H,m), 5.28-5.41 (2H,s) Reference Example 46 Preparation of 1-Oleoyltetrahydro-1,4-diazepine Tetrahydro-1,4-diazepine (5.0 g) and 3.0 g of oleyl chloride were Example reacted in the same manner as in Reference Example 44 to obtain 2.76 g of the objective compound (yield: 75%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₂₃H₄₄N₂O Calculated 364.3453 Found 364.3451 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.21-1.39 (20H,m), 1.59-2.08 8H,m), 2.27-2.38 (2H,m), 2.85-3.01 (4H,m), 3.50-3.68 (4H,m), 5.29-5.40 (2H,m) Reference Example 47 (A) Preparation of 1-Benzyloxycarbonyl-4-[1-oxo-3-[N-2,2,5,5,-tetramethyl-1,3-dioxane-4-carbonyl)amino]propyl]piperazine 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (5.18 g) and 6.60 g of 1-benzyloxycarbonyl-piperazine were reacted in the same manner as in Reference Example 25 to obtain 8.60 g of the ojective compound (yield: 94%). Property: Oily IR(cm⁻¹, neat): νCO 1706, 1648 Mass Spectrometric Analysis: Molecular formula C₂₄H₃₅N₃O₆ Calculated 461.2525 Found 461.2537 NMR(δ, CDCl₃): 0.95 (3H,s), 1.03 (3H,s), 1.41 (3H,s), 1.46 (3H,s), 2.49-2.64 (2H,m), 3.27 (1H,d,J=12Hz), 3.35-3.62 (10H,m), 3.67 (1H,d,J=12Hz), 4.06 (1H,m), 5.15 (2H,s), 7.09 (1H,t,J=6Hz), 7.28-7.43 (5H,m) (B) Preparation of 1-[1-Oxo-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propyl]piperazine 1-Benzyloxycarbonyl-4-[1-oxo-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propyl]piperazine (1.4 g) was reacted in the same manner as in Reference Example 7 to obtain 0.993 g of the ojective compound (yield: 100%). Property: Oily Mass Spectrometric Analysis: Molecular formula C₁₆H₂₉N₃O₄ Calculated 327.2158 Found 327.2166 NMR(δ, CDCl₃): 0.97 (3H,s), 1.04 (3H,s), 1.42 (3H,s), 1.47 (3H,s), 2.47-2.63 (2H,m), 2.79-2.97 (4H,m), 3.40-3.76 (7H,m), 3.28 (1H,d,J=12Hz), 4.07 (1H,s), 7.12 (1H,t,J=6Hz) Example 1 Preparation of N-[2-(Oleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (211 mg) was added to a solution of 372 mg of 2-oleoylaminoaniline and 259 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid in 30 ml of methylene chloride under ice cooling. The mixture was stirred in situ for one night. The reaction mixture was washed with water and dried over anhydrous sodium sulfate, filtered and the filtate evaporation under vacuum to obtain the crude title products. Then, the residue obtained was subjected to silica gel column chromatography to obtain 500 mg of the title compound (yield: 82%). Property: Oily Specific Rotary Power [α] D : +29.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1664 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₉N₃O₅ Calculated 613.4454 Found 613.4425 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.22-1.40 (20H,m), 1.42 (3H,s), 1.45 (3H,s), 1.62-1.77 (2H,m), 1.94-2.09 (4H,m), 2.36 (2H,t,J=7Hz), 2.60 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.55-3.66 (2H,m), 3.69 (1H,d,J=12Hz), 4.10 (1H,s), 5.29-5.42 (2H,m), 7.14-7.48 (2H,m), 7.39-7.48 (2H,m), 8.18 (1H,s), 8.60 (1H,brs) Example 2 Preparation of N-[2-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide 2-Oleoylaminoaniline (744 mg) and 606 mg of 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 810 mg of the title compound (yield: 65%). Property: Oily Specific Rotary Power [α] D : +6.30°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1750, 1660 Mass Spectrometric Analysis: Molecular formula C₃₇H₅₉N₃O₇ Calculated 657.4352 Found 657.4369 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.02 (3H,s), 1.06 (3H,s), 1.23-1.45 (20H,m), 1.67-1.79 (2H,m), 1.95-2.09 (4H,m), 2.03 (2H,s), 2.04 (3H,s), 2.42 (2H,t,J =7Hz), 2.58 (2H,t,J=6Hz), 3.49-3.72 (2H,m), 3.83 (1H,d,J=11Hz), 4.02 (1H,d,J=11Hz), 4.89 (1H,s), 5.30-5.44 (2H,m), 6.72-6.81 (1H,m), 7.19-7.32 (2H,m), 7.37 (1H,d,J=8Hz), 7.59 (1H,d,J=8Hz), 7.88 (1H,brs), 8.19 (1H,brs) Example 3 Preparation of N-[2-(Oleoylamino)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide An aqueous 1N sodium hydroxide solution (1,5 ml) was added to a solution of 470 mg of N-[2-(oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide in 4 ml of methanol with stirring at room tempeature, and the mixture was stirred for additional 30 minutes. After completion of the reaction, 10 ml of water was added to the reaction mixture, which was then extracted with 20 ml of methylene chloride. The methylene chloride layer was washed with water and then with brine, and dried over anhydrous sodium sulfate. After removing the solvent by evaporation, the residue obtained was subjected to silica gel column chromatography to obtain 377 mg of the title compound (yield: 94%). Property: Oily Specific Rotary Power [α] D : +21.9°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νNH , νOH , νC=O 1660 Mass Spectrometric Analysis: Molecular formula C₃₃H₅₅N₃O₅ Calculated 573.4141 Found 573.4146 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 0.97 (3H,s), 1.20-1.42 (20H,m), 1.62-1.76 (2H,m), 1.94-2.01 (4H,m), 2.38 (2H,t,J=7Hz), 2.52 (2H,t,J=6Hz), 3.44 (2H,s), 3.49-3.72 (2H,m), 3.94 (1H,s), 5.28-5.42 (2H,m), 7.13-7.21 (2H,m), 7.29-7.49 (3H,m), 8.31 (1H,s), 8.69 (1H,s) Example 4 Preparation of N-[2-(Linoleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide A solution of 349 mg of N-(2-aminophenyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide, 280 mg of linolic acid and 227 mg of dicyclohexylcarbodiimide in 15 ml of toluene was heated under reflux for 2 hours. After cooling the reaction mixture, the crystals formed were filtered. The filtrate was concentrated and the residue obtained was subjected to silica gel column chromatography to obtain 266 mg of the title compound (yield: 44%). Property: Oily Specific Rotary Power [α] D : +27.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1662 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₇N₃O₅ Calculated 611.4298 Found 611.4264 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.23-1.44 (14H,m), 1.42 (3H,s), 1.45 (3H,s), 1.65-1.77 (2H,m), 1.91-2.10 (4H,m), 2.37 (2H,t,J=7Hz), 2.62 (2H,t,J=6Hz), 2.77 (2H,t,J= 6Hz), 3.28 (1H,d,J=12Hz), 3.56-3.67 (2H,m), 3.69 (1H,d,J=12Hz), 4.10 (1H,m), 5.29-5.44 (4H,m), 7.09 (1H,t,J=6Hz), 7.15-7.22 (2H,m), 7.42-7.49 (2H,m), 8.11 (1H,s), 8.55 (1H,s) Example 5 Preparation of N-[2-(Linolenoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(2-Aminophenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide (349 mg) and 278 mg of linolenic acid were reacted in the same manner as in Example 4 to obtain 271 mg of the title compound (yield: 45%). Property: Oily Specific Rotary Power [α] D : +26.2°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1666 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₅N₃O₅ Calculated 609.4141 Found 609.4144 NMR(δ, CDCl₃): 0.97 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,S), 1.23-1.43 (8H,m), 1.42 (3H,s), 1.46 (3H,s), 1.65-1.77 (2H,m), 2.03-2.12 (4H,m), 2.38 (2H,t,J=7Hz), 2.63 (2H,t,J=6Hz), 2.75-2.83 (4H,m), 3.28 (1H,d,J=12Hz), 3.58-3.70 (2H,m), 3.69 (1H,d,J=12Hz), 4.11 (1H,s), 5.29-5.43 (6H,m), 7.09 (1H,t,J=6Hz), 7.17-7.22 (2H,m), 7.42-7.51 (2H,m), 8.06 (1H,brs), 8.51 (1H,brs) Example 6 Preparation of N-[2-(Stearoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide To a solution of 349 mg of N-(2-aminophenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide in 20 ml of methylene chloride were added portion-wise 1 ml of pyridine and then a solution of 303 mg of stearoyl chloride in 3 ml of methylene chloride with stirring under ice cooling. The mixture obtained was stirred for additional 1 hour. The reaction mixture was then washed with water and dried over anhydrous sodium sulfate, followed by removal of the solvent by evaporation. The residue obtained was subjected to silica gel column chromatography to obtain 507 mg of the title compound (yield: 82%). Property: Oily Specific Rotary Power [α] D : +27.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1664 Mass Spectrometric Analysis: Molecular formula C₃₆H₆₁N₃O₅ Calculated 615.4611 Found 615.4582 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.20-1.43 (28H,m), 1.42 (3H,s), 1.46 (3H,s), 1.68-1.78 (2H,m), 2.40 (2H,t,J=7Hz), 2.65 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.58-3.72 (2H,m), 3.69 (1H,d,J=12Hz), 4.11 (1H,s), 7.08 (1H,t,J=6Hz), 7.17-7.23 (2H,m), 7.42-7.53 (2H,m), 8.00 (1H,s), 8.49 (1H,s) Example 7 Preparation of N-[2-(Lauroylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane 4-carbonyl)amino]propanamide N-(2-Aminophenyl)-3-[N-(2,2,5,5-tetramethyl -1,3-dioxane-4-carbonyl)amino]propanamide (349 mg) and 219 mg of lauroyl chloride were reacted in the same manner as in Example 6 to obtain 454 mg of the title compound (yield: 86%). Property: Oily Specific Rotary Power [α) D : +31.7°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1664 Mass Spectrometric Analysis: Molecular formula C₃₀H₄₉N₃O₅ Calculated 531.3672 Found 531.3692 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.21-1.43 (16H,m), 1.42 (3H,s), 1.45 (3H,s), 1.65-1.77 (2H,m), 2.38 (2H,t,J=7Hz), 2.61 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.55-3.68 (2H,m), 3.69 (1H,d,J=12Hz), 4.10 (1H,s), 7.09 (1H,t,J=12Hz), 7.14-7.22 (2H,m), 7.40-7.49 (2H,m), 8.13 (1H,s), 8.57 (1H,s) Example 8 Preparation of N-[2-(Octanoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(2-Aminophenyl)-3-[N-(2,2,5,5-tetramethyl -1,3-dioxane-4-carbonyl)amino]propanamide (349 mg) and 163 mg of octanoyl chloride were reacted in the same manner as in Example 6 to obtain 413 mg of the title compound (yield: 87%). Property: Oily Specific Rotary Power [α) D : +35.1°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1664 Mass Spectrometric Analysis: Molecular formula C₂₆H₄₁N₃O₅ Calculated 475.3046 Found 475.3039 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.23-1.38 (8H,m), 1.42 (3H,s), 1.45 (3H,s), 1.62-1.77 (2H,m), 2.37 (2H,t,J=7Hz), 2.60 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.57-3.71 (2H,m), 3.69 (1H,d,J=12Hz), 4.10 (1H,s), 7.09 (1H,t,J=6Hz), 7.14-7.21 (2H,m), 7.40-7.49 (2H,m), 8.16 (1H,s), 8.59 (1H,s) Example 9 Preparation of N-[3-(Linoleoylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 3-Linoleoylaminoaniline (555 mg) and 389 mg of 3-[N-(2-Aminophenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 786 mg of the title compound (yield: 86%). Property: Oily Specific Rotary Power [α] D : +30.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1664 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₇N₃O₅ Calculated 611.4298 Found 611.4389 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,S), 1.23-1.42 (14H,m), 1.41 (3H,s), 1.45 (3H,s), 1.62-1.78 (2H,m), 1.99-2.08 (4H,m), 2.33 (2H,t,J=7Hz), 2.64 (2H,t,J=6Hz), 2.77 (2H,t,J= 6Hz), 3.26 (1H,d,J=12Hz), 3.52-3.73 (2H,m), 3.68 (1H,d,J=12Hz), 4.11 (1H,s), 5.29-5.43 (2H,m), 7.09 (1H,t,J=6Hz), 7.22-7.29 (2H,m), 7.34-7.42 (2H,m), 7.79 (1H,s), 8.36 (1H,brs) Example 10 Preparation of N-[3-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide 3-Oleoylaminoaniline (744 mg) and 606 mg of 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 860 mg of the title compound (yield: 65%). Property: Oily Specific Rotary Power [α] D : +12.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1750, 1668 Mass Spectrometric Analysis: Molecular formula C₃₇H₅₉N₃O₇ Calculated 657.4352 Found 657.4342 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 1.03 (3H,s), 1.05 (3H,s), 1.21-1.42 (20H,m), 1.61-1.77 (2H,m), 1.97-2.13 (4H,m), 2.05 (3H,s), 2.10 (3H,s), 2.33 (2H,t,J =7Hz), 2.56 (2H,t,J=6Hz), 3.55-3.68 (2H,m), 3.87 (1H,d,J=11Hz), 4.02 (1H,d,J=10Hz), 4.91 (1H,s), 5.29-5.42 (2H,m), 6.84 (1H,d,J=6Hz), 7.25 (1H,d,J=8Hz), 7.33 (1H,d,J=8Hz), 7.41 (1H,d,J=8Hz), 7.54 (1H,brs), 7.63 (1H,brs), 8.01 (1H,brs) Example 1 1 Preparation of N-[3-(Oleoylamino)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-[3-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy -3,3-dimethyl-1-oxobutyl)amino]propanamide (470 mg) was reacted in the same manner as in Example 3 to obtain 378 mg of the title compound (yield: 94%). Property: Oily Specific Rotary Power [α] D : +23.1°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1660 Mass Spectrometric Analysis: Molecular formula C₃₃H₅₅N₃O₅ Calculated 573.4141 Found 573.4146 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (3H,s), 0.98 (3H,s), 1.21-1.42 (20H,m), 1.62-1.73 (2H,m), 1.93-2.10 (4H,m), 2.32 (2H,t,J=7Hz), 2.52 (2H,brs), 3.50-3.70 (2H,m), 4.01 (1H,s), 5.29-5.43 (2H,m), 7.17-7.31 (3H,m), 7.53-7.62 (1H,m), 7.71 (1H,brs), 7.92-8.00 (1H,m), 8.46-8.55 (1H,m) Example 12 Preparation of N-[4-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide 4-Oleoylaminoaniline (744 mg) and 606 mg of 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 900 mg of the title compound (yield: 69%). Property: Oily Specific Rotary Power [α] D : +17.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1754, 1660 Mass Spectrometric Analysis: Molecular formula C₃₇H₅₉N₃O₇ Calculated 657.4352 Found 657.4357 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.02 (3H,s), 1.05 (3H,s), 1.19-1.43 (20H,m), 1.66-1.77 (2H,m), 1.92-2.09 (4H,m), 2.05 (3H,s), 2.08 (3H,s), 2.34 (1H,t,J =7Hz), 2.56 (2H,t,J=6Hz), 3.50-3.71 (2H,m), 3.84 (1H,d,J=11Hz), 4.02 (1H,d,J=11Hz), 4.89 (1H,s), 5.29-5.42 (2H,m), 6.76 (1H,t,J=6Hz), 7.13 (1H,brs), 7.44-7.52 (4H,m), 7.64 (1H,brs) Example 13 Preparation of N-[4-(Oleoylamino)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-[4-(Oleoylamino)phenyl]-3-[N-(2,4-diacetoxy -3,3-dimethyl-1-oxobutyl)amino]propanamide (657 mg) was reacted in the same manner as in Example 3 to obtain 495 mg of the title compound (yield: 86%). Property: Melting Point 146.2 - 148.1°C Specific Rotary Power [α] D : +10.2°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1664 Mass Spectrometric Analysis: Molecular formula C₃₇H₅₉N₃O₇ Calculated 573.4141 Found 573.4144 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.89 (3H,s), 0.95 (3H,s), 1.15-1.43 (20H,m), 1.62-1.77 (2H,m), 1.92-2.08 (4H,m), 2.34 (2H,t,J=7Hz), 2.56 (2H,brs), 3.45 (2H,s), 3.58 (2H,brs), 3.96 (1H,s), 5.27-5.42 (2H,m), 7.25-7.39 (4H,m), 7.48 (1H,brs), 7.71 (1H,brs), 8.54 (1H,brs) Example 14 Preparation of N-[4-(Lauroylamino)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 4-Lauroylaminoaniline (250 mg) and 223 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 381 mg of the title compound (yield: 72%). Property: Melting Point 144.3 - 144.9°C Specific Rotary Power [α] D : +34.6°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1664 Mass Spectrometric Analysis: Molecular formula C₃₀H₄₉N₃O₅ Calculated 531.3672 Found 531.3675 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.95 (3H,s), 1.04 (3H,s), 1.22-1.40 (16H,m), 1.41 (3H,s), 1.45 (3H,s), 1.68-1.80 (2H,m), 2.34 (2H,t,J=7Hz), 2.65 (2H,t,J=6Hz), 2.34 (2H,t,J=7Hz), 2.65 (2H,t,J= 7Hz), 3.27 (1H,d,J=12Hz), 3.50-3.75 (2H,m), 3.68 (1H,d,J=12Hz), 4.10 (1H,s), 7.08 (1H,d,J= 6Hz), 7.16 (1H,s), 7.46 (2H,d,J=8Hz), 7.49 (2H,d,J=8Hz), 8.09 (1H,s) Example 15 Preparation of 2-(Oleoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate A solution of 303 mg of 2-oleoylaminophenol, 259 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid, 227 mg of dicyclohexylcarbodiimide and 122 mg of 4-dimethylamino pyridine in 15 ml of toluene was heated under reflux for 2 hours. After cooling the reaction mixture, the crystals formed were filtered. The filtrate was concentrated and the residue obtained was subjected to silica gel column chromatography to obtain 445 mg of the title compound (yield: 72%). Property: Oily Specific Rotary Power [α] D : +26.9°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1772, 1658 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₈N₂O₆ Calculated 614.4294 Found 614.4271 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (3H,s), 1.00 (3H,s), 1.22-1.43 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.65-1.78 (2H,m), 1.93-2.08 (4H,m), 2.44 (2H,t,J=7Hz), 2.80 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.69-3.82 (2H,m), 3.68 (1H,d,J=12Hz), 4.09 (1H,s), 5.29-5.39 (2H,m), 7.00 (1H,t,J= 6Hz), 7.06-7.12 (2H,m), 7.19-7.27 (1H,m), 8.22 (1H,d,J=8Hz), 8.39 (1H,s) Example 16 Preparation of 4-(Oleoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate 4-Hydroxyoleoylanilide (565 mg) and 393 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 930 mg of the title compound (yield: 99%). Property: Oily Specific Rotary Power [α] D : +18.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1760, 1662 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₈N₂O₆ Calculated 614.4294 Found 614.4312 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.00 (3H,s), 1.06 (3H,s), 1.23-1.43 (20H,m), 1.43 (3H,s), 1.45 (3H,s), 1.65-1.78 (2H,m), 1.93-2.09 (4H,m), 2.35 (2H,t,J=7Hz), 2.82 (2H,t,J=6Hz), 3.29 (1H,d,J= 12Hz), 3.52-3.77 (2H,m), 3.70 (1H,d,J=12Hz), 4.11 (1H,s), 5.29-5.41 (2H,m), 6.98-7.07 (1H,m), 7.03 (2H,d,J=8Hz), 7.54 (2H,d,J=8Hz) 7.18 (1H,s) Example 17 Preparation of 4-(Oleoylamino)phenyl 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate 4-Oleoylaminophenol (372 mg) and 259 mg of 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 255 mg of the title compound (yield: 39%). Property: Oily Specific Rotary Power [α] D : +19.4°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1750, 1666 Mass Spectrometric Analysis: Molecular formula C₃₇H₅₈N₂O₈ Calculated 658.4193 Found 658.4191 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.03 (3H,s), 1.08 (3H,s), 1.22-1.42 (20H,m), 1.66-1.78 (2H,m), 1.96-2.07 (4H,m), 2.01 (3H,s), 2.04 (3H,s), 2.35 (2H,t,J =7Hz), 2.77-2.82 (2H,m), 3.84 (1H,d,J=12Hz), 4.05 (1H,d,J=12Hz), 4.97 (1H,s), 5.27-5.42 (2H,m), 6.61 (1H,t,J=6Hz), 7.04 (2H,d,J=8Hz), 7.15 (1H,brs), 7.54 (2H,d,J=8Hz) Example 18 Preparation of 4-(Oleoylamino)phenyl 3-[N-(2,4-dibenzyloxy-3,3-dimethyl-1-oxobutyl)amino]propionate 3-[N-(2,4-Dibenzyloxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid (200 mg) and 186 mg of 4-(Oleoylamino)phenol were reacted in the same manner as in Example 15 to obtain 312 mg of the title compound (yield: 97%). Property: Oily Specific Rotary Power [α] D : +19.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1760, 1652 Mass Spectrometric Analysis: Molecular formula C₄₇H₆₆N₂O₆ Calculated 754.4920 Found 754.4890 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.94 (3H,s), 1.05 (3H,s), 1.20-1.41 (20H,m), 1.64 1.75 (2H,m), 1.95-2.09 (4H,m), 2.34 (3H,s), 2.75 (3H,t,J=7Hz), 3.23 (1H,t,J=9Hz), 3.61 (2H,dd,J=6Hz,6Hz), 3.41 (1H,d,J=9Hz), 3.90 (1H,s), 4.34-4.55 (4H,m), 5.29-5.42 (2H,m), 6.95 (2H,d,J=8Hz), 7.03 (1H,d,J=8Hz), 7.23-7.39 (10H,m), 7.50 (2H,d,J= 8Hz) Example 19 Preparation of 4-(Oleoylamino)phenyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate A solution of 500 mg of 4-(Oleoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate in a mixed solvent composed of 20 ml of acetic acid and 10 ml of water was stirred at room temperature for 15 hours. 20 ml of water was then added to the reaction mixture, which was then extracted with methylene chloride. The methylene chloride layer was washed with water, and dried over anhydrous sodium sulfate. After removal of the solvent under vacuum evaporation, the residue obtained was subjected to silica gel column chromatography to obtain 395 mg of the title compound (yield: 85%). Property: Oily Specific Rotary Power [α] D : +14.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1758, 1662 Mass Spectrometric Analysis: Molecular formula C₃₃H₅₄N₂O₆ Calculated 574.3981 Found 574.3952 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.93 (3H,s), 1.03 (3H,s), 1.21-1.43 (20H,m), 1.65-1.71 (2H,m), 1.71-2.18 (6H,m), 2.35 (2H,t,J=7Hz), 3.82 (2H,t,J=6Hz), 3.50 (1H,d,J=10Hz,), 3.60-3.74 (2H,m), 3.54 (1H,d,J=10Hz), 4.04 (1H,s), 5.28-5.43 (2H,m), 7.15-7.26 (2H,m), 7.04 (2H,d,J=8Hz), 7.52 (2H,d,J=8Hz) Example 20 Preparation of 4-(Linolenoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate 4-Linolenoylaminoanilide (369 mg) and 259 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 431 mg of the title compound (yield: 71%). Property: Oily Specific Rotary Power [α] D : +20.6°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1760, 1662 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₂N₂O₆ Calculated 608.3825 Found 608.3836 NMR(δ, CDCl₃): 0.98 (3H,t,J=7Hz), 1.00 (3H,s), 1.06 (3H,s), 1.24-1.42 (8H,m), 1.43 (3H,s), 1.45 (3H,s), 1.64-1.78 (2H,m), 2.01-2.12 (4H,m), 2.35 (2H,t,J=7Hz), 2.72-2.86 (6H,m), 3.29 (1H,d,J= 12Hz), 3.52-3.77 (2H,m), 3.70 (1H,d,J=12Hz), 4.11 (1H,s), 5.28-5.44 (6H,m), 7.00 (1H,t,J= 6Hz), 7.03 (2H,d,J=8Hz), 7.15 (1H,s), 7.54 (2H,d,J=8Hz) Example 21 Preparation of N-[4-(Oleoylthio)phenyl-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide S-4-Aminophenyl thiooleate (778 mg) and 518 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 1.05 g of the title compound (yield: 83%). Property: Oily Specific Rotary Power [α] D : +29.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1696, 1666 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₈N₂O₅S Calculated 630.4066 Found 630.4069 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.04 (3H,s), 1.21-1.39 (20H,m), 1.42 (3H,s), 1.46 (3H,s), 1.60-1.74 (2H,m), 1.92-2.09 (4H,m), 2.63 (2H,t,J=7Hz), 2.68 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.54-3.75 (2H,m), 3.68 (1H,d,J=12Hz), 4.10(1H,s), 5.30-5.42 (2H,m), 7.08 (1H,t,J= 6Hz), 7.35 (2H,d,J=8Hz), 7.63 (2H,d,J=8Hz), 8.29 (1H,s) Example 22 Preparation of N-[4-(Oleoylthio)phenyl-3-[N-(2,4-dihydro-3,3-dimethyl-1-oxobutyl)amino]propanamide N-[4-(Oleoylthio)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide (500 mg) was reacted in the same manner as in Example 19 to obtain 406 mg of the title compound (yield: 87%). Property: Oily Specific Rotary Power [α] D : +16.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1670 Mass Spectrometric Analysis: Molecular formula C₃₃H₅₄N₂O₅S Calculated 590.3753 Found 590.3731 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (3H,s), 0.98 (3H,s), 1.20-1.42 (20H,m), 1.65-1.77 (2H,m), 1.93-2.09 (4H,m), 2.57 (2H,t,J=6Hz), 2.66 (2H,t,J=6Hz), 3.25 (2H,brs), 3.48 (2H,brs), 3.50-3.69 (2H,m), 4.01 (1H,s), 5.30-5.42 (2H,m), 7.28 (2H,t,J= 9Hz), 7.50 (2H,d,J=9Hz), 7.54 (2H,d,J=6Hz), 8.62 (1H,s) Example 23 Preparation of S-4-(Oleoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanethioate S-4-Aminophenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanethioate (281 mg) and 229 mg oleoyl chloroide were reacted in the same manner as in Example 6 to obtain 185 mg of the title compound (yield: 38%). Property: Oily Sepcific Rotary Power [α] D : +7.90°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1704, 1652 Mass Spectrometric Analysis: Molecular formula C₃₆H₅₈N₂O₅S Calculated 630.4066 Found 630.4044 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.00 (3H,s), 1.05 (3H,s), 1.15-1.42 (20H,m), 1.42 (3H,s), 1.45 (3H,s), 1.65-1.79 (2H,m), 1.92-2.08 (4H,m), 2.37 (2H,t,J=7Hz), 2.82-3.01 (2H,m), 3.29 (1H,d,J= 6Hz), 3.47-3.69 (2H,m), 3.69 (1H,d,J=12Hz), 4.09 (1H,s), 5.29-5.42 (2H,m), 6.85-6.92 (1H,m), 7.16 (1H,s), 7.34 (2H,d,J=8Hz), 7.60 (2H,d,J=8Hz) Example 24 Preparation of S-4-(Oleoylamino)phenyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanethioate S-4-(Oleoylamino)phenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanethioate (483 mg) was reacted in the same manner as in Example 19 to obtain 404 mg of the title compound (yield: 89%). Property: Oily Specific Rotary Power [α] D : +8.80°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1698, 1670 Mass Spectrometric Analysis: Molecular formula C₃₃H₅₄N₂O₅S Calculated 590.3753 Found 590.3762 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (3H,s), 1.02 (3H,s), 1.19-1.43 (20H,m), 1.67-1.79 (2H,m), 1.87-2.17 (6H,m), 2.36 (2H,t,J=7Hz), 2.92 (2H,t,J=6Hz), 3.48 (1H,d,J=12Hz), 3.53 (1H,d,J=12Hz), 3.56-3.65 (2H,m), 4.01 (1H,s), 5.28-5.42 (2H,m), 7.12 (1H,t,J=6Hz), 7.26 (1H,brs), 7.34 (2H,d,J =8Hz), 7.59 (2H,d,J=8Hz) Example 25 Preparation of S-4-(Oleoylamino)phenyl 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanethioate S-4-aminophenyl 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanethioate (276 mg) and 196 mg of oleoyl chloride were reacted in the same manner as in Example 6 to obtain 304 mg of the title compound (yield: 69%). Property: Oily Specific Rotary Power [α] D : +21.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1750, 1670 Mass Spectrometric Analysis: Molecular formula C₃₇H₅₈N₂O₇S Calculated 674,3964 Found 674.3976 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.00 (3H,s), 1.06 (3H,s), 1.21-1.33 (20H,m), 1.62-1.77 (2H,m), 1.94-2.08 (4H,m), 2.06 (3H,s), 2.10 (3H,s), 2.37 (2H,t,J= 7Hz), 2.89 (2H,t,J=6Hz), 3.44-3.68 (2H,m), 3.82 (1H,d,J=11Hz), 4.03 (1H,d,J=11Hz), 4.97 (1H,s), 5.29-5.41 (2H,m), 6.47 (1H,t,J=6Hz), 7.19-7.32 (2H,m), 7.17 (1H,s), 7.35 (2H,d,J= 8Hz), 7.61 (2H,d,J=8Hz) Example 26 Preparation of N-[2-(Oleoyloxy)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(2-Hydroxyphenyl)-3-[N-(2,2,5,5-tetramethyl -1,3-dioxane-4-carbonyl)amino]propanamide (350 mg) and 282 mg of oleic acid were reacted in the same manner as in Example 15 to obtain 411 mg of the title compound (yield: 67%). property: Oily Secific Rotary Power [α] D : +32.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1768, 1668 Mass Spectrometric Analysis: Molecular Formula C₃₆H₅₈N₂O₆ Calculated 614,4294 Found 614.4294 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.23-1.45 (20H,m), 1.40 (3H,s), 1.45 (3H,s), 1.71-1.83 (2H,m), 1.92-2.08 (4H,m), 2.58-2.67 (4H,m), 3.27 (1H,d,J=12Hz), 3.56-3.64 (2H,m), 3.67 (1H,d,J=12Hz), 4.07 (1H,s), 5.30-5.42 (2H,m), 7.03-7.17 (3H,m), 7.19-7.29 (1H,m), 7.49 (1H,brs), 8.18 (1H,s,J=8Hz) Example 27 Preparation of N-[4-(Oleoyloxy)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-(4-hydroxyphenyl)-3-[N-(2,4-diacetoxy-3,3 -dimethyl-1-oxobutyl)amino]propanamide (394 mg) and 301 mg of oleoyl chloride were reacted in the same manner as in Example 6 to obtain 530 mg of the title compound (yield: 81%). property: Oily Secific Rotary Power [α] D : +14.9°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1746, 1666 Mass Spectrometric Analysis: Molecular Formula C₃₇H₅₈N₂O₈ Calculated 658.4193 Found 658.4184 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.02 (3H,s), 1.05 (3H,s), 1.22-1.42 (20H,m), 1.68-1.79 (2H,m), 1.94-2.09 (4H,m), 2.07 (3H,s), 2.51-2.59 (4H,m), 3.54-3.71 (2H,m), 3.84 (1H,d,J=12Hz), 4.02 (1H,d,J=12Hz), 4.88 (1H,s), 5.28-5.42 (2H,m), 6.72 (1H,d,J=6Hz), 7.34 (2H,d,J=8Hz), 7.54 (2H,d,J=8Hz), 7.71 (1H,brs) Example 28 Preparation of N-[4-(Oleoyloxy)phenyl]-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-[4-(Oleoyloxyphenyl)-3-[N-(2,2,5,5-tetramethyl -1,3-dioxane-4-carbonyl)amino]propanamide (1.0 g) was reacted in the same manner as in Example 19 to obtain 830 mg of the title compound (yield: 89%). property: Oily Secific Rotary Power [α] D : +21.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1760, 1660 Mass Spectrometric Analysis: Molecular Formula C₃₃H₅₄N₂O₆ Calculated 574.3981 Found 574.3977 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 0.98 (3H,s), 1.19-1.46 (20H,m), 1.41 (3H,s), 1.68-1.79 (2H,m), 1.93-2.09 (4H,m), 2.55 (2H,t,J=7Hz), 2.59 (2H,t,J=6Hz), 2.72 (2H,brs), 3.55-3.68 (2H,m), 3.48 (2H,s), 3.98 (1H,s), 5.29-5.42 (2H,m), 7.45-7.53 (1H,m), 7.00 (2H,d,J=8Hz), 7.52 (2H,d,J=8Hz), 8.35 (1H,s) Example 29 Preparation of N-[4-(Oleoyloxy)phenyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(4-(Hydroxyphenyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide (1.44 g) and 1.20 g of oleoyl chloride were reacted in the same manner as in Example 6 to obtain 1.93 g of the title compound (yield: 79%). property: Oily Specific Rotary Power [α] D : +32.6°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1764, 1668 Mass Spectrometric Analysis: Molecular Formula C₃₆H₅₈N₂O₆ Calculated 614.4294 Found 614.4319 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.23-1.45 (20H,m), 1.41 (3H,s), 1.46 (3H,s), 1.66-1.70 (2H,m), 1.93-2.09 (4H,m), 2.54 (2H,t,J=7Hz), 2.66 (2H,t,J=6Hz), 3.27 (1H,d,J =12Hz), 3.52-3.77 (2H,m), 3.68 (1H,d,J=12Hz), 4.10 (1H,s), 5.29-5.42 (2H,m), 7.01-7.10 (1H,m), 7.01 (2H,d,J=8Hz), 7.57 (2H,d,J=8Hz), 8.11 (1H,s) Example 30 Preparation of N-[4-(Oleoythio)phenyl]-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide S-p-aminophenyl thiooleate (799 mg) and 606 mg of 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 780 mg of the title compound (yield: 58%). property: Oily Specific Rotary Power [α] D : +14.5°(C=1.0, CHCl₃) IR(cm⁻¹, neat): νC=O 1748, 1672 Mass Spectrometric Analysis: Molecular Formula C₃₇H₅₈N₂O₇S Calculated 674.3964 Found 674.3991 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.03 (3H,s), 1.06 (3H,s), 1.22-1.41 (20H,m), 1.64-1.75 (2H,m), 1.96-2.08 (4H,m), 2.05 (3H,s), 2.08 (3H,s), 2.58 (2H,t,J =6Hz), 2.64 (2H,t,J=7Hz), 3.55-3.70 (2H,m), 3.85 (1H,d,J=11Hz), 4.02 (1H,d,J=11Hz), 4.87 (1H,s), 5.28-5.43 (2H,m), 6.69 (1H,t,J= 6Hz), 7.34 (2H,d,J=8Hz), 7.60 (2H,d,J=8Hz), 7.81 (1H,brs) Example 31 Preparation of N-[2-(Oleoylaminoethyl)-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide A solution of 1.07 g of N-(2-aminoethyl)oleamide and 1.40 g of 4-nitrophenyl 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate in 40 ml of tetrahydrofuranwas stirred at room temperature for 15 hours. The solvent was then distilled off under reduced pressure. The residue was dissolved in ethyl acetate, and the solution was washed with aqueous potassium carbonate solution and then with water. The organic layer was dried over anhydrous sodium sulfate, and the solvent was distilled off. The residue was subjected to silica gel column chromatography to obtain 4.45 g of the refined title compound (yield: 75%). property: Oily IR(cm⁻¹, neat): 2980, 1740, 1650 Mass Spectrometric Analysis: Molecular Formula C₃₃H₅₉N₃O₇ Calculated 609.4352 Found 609.4342 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.05 (3H,s), 1.09 (3H,s), 1.10-1.40 (18H,m), 1.54-2.42 (12H,m), 2.07 (3H,s), 2.16 (3H,s), 3.20-3.60 (6H,m), 3.86 (1H,t,J=11Hz), 4.05 (1H,d,J=11Hz), 4.86 (1H,s), 5.30-5.40 (2H,m), 6.14-6.22 (1H,brs), 6.52-6.60 (1H,brs), 7.04-7.12 (1H,brs) Example 32 Preparation of N-[2-(Oleoylaminoethyl)-3-[N-(2,4-dihyroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-(2-Oleoylaminoethyl)-3-[N-(2,4-diacetoxy-3,3 -dimethyl-1-oxobutyl)amino]propanamide (200 mg) was reacted in the same manner as in Example 3 to obtain 150 mg of the title compound (yield: 86%). property: Oily IR(cm⁻¹, neat): νOH 3324, νC=O 1650 Mass Spectrometric Analysis: Molecular Formula C₂₉H₅₃N₃O₄ Calculated 507.4011 Found 507.4044 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.94 (3H,s), 1.00 (3H,s), 1.16-1.40 (17H,m), 1.50-1.64 (2H,m), 1.92-2.08 (4H,m), 2.19 (2H,t,J=7Hz), 2.30-2.80 (6H,s), 3.20-3.54 (6H,m), 3.62-3.74 (1H,m), 4.02 (1H,s), 5.39-5.44 (2H,m), 6.40-6.50 (1H,m), 6.96-7.04 (1H,m), 7.45-7.53 (1H,m) Example 33 Preparation of N-[2-(N-Oleoylamino)ethyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(2-Aminoethyl)olelamide (3.38 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 4.58 g of the title compound (yield: 81%). property: Oily IR(cm⁻¹, neat): νC=O 1650 Mass Spectrometric Analysis: Molecular Formula C₃₂H₅₉N₃O₅ Calculated 565.4455 Found 565.4454 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.23-1.40 (14H,m), 1.43 (3H,s), 1.47 (H,s), 1.52-1.86 (6H,m), 1.92-2.10 (4H,m), 2.18 (2H,t,J=7Hz), 2.46 (2H,t,J=6Hz), 3.29 (1H,d,J =12Hz), 3.38 (3H,brs), 3.44-3.62 (4H,m), 3.67 (1H,d,J=12Hz), 4.08 (1H,s), 5.30-5.42 (2H,m), 6.20-6.30 (1H,brs), 6.65-6.73 (1H,brs), 6.99-7.08 (1H,brs) Example 34 Preparation of N-[3-(N-Oleoylamino)propyl]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(3-Aminopropyl)oleamide (3.39 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 2.7 g of the title compound (yield: 47%). property: Oily IR(cm⁻¹, neat): νC=O 1660 Mass Spectrometric Analysis: Molecular Formula C₃₃H₆₁N₃O₅ Calculated 579.4611 Found 579.4630 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.10-1.40 (20H,m), 1.42 (3H,s), 1.46 (3H,s), 1.54-1.90 (5H,m), 1.90-2.10 (3H,m), 2.20 (2H,t,J=7Hz), 2.47 (2H,t,J=6Hz), 3.20-3.36 (5H,m), 3.48-3.66 (2H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 5.30-5.40 (2H,m), 6.15-6.25 (1H,m), 6.58-6.66 (1H,m), 7.02-7.10 (1H,m) Example 35 Preparation of N-(3-(Oleoylaminopropyl)-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-(3-Oleoylaminopropyl)- 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide (0.58 g) was reacted in the same manner as in Example 19 to obtain 0.48 g of the title compound (yield: 89%). property: Oily IR(cm⁻¹, neat): νC=O 1650 Mass Spectrometric Analysis: Molecular Formula C₃₀H₅₇N₃O₅ Calculated 539.4297 Found 539.4291 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.01 (3H,s), 1.20-1.40 (20H,m), 1.55-1.68 (4H,m), 1.92-2.08 (4H,m), 2.19 (2H,t,J=6Hz), 2.36-2.54 (2H,m), 3.16-3.40 (6H,m), 3.48 (2H,s), 3.42-3.56 (1H,m), 3.62-3.76 (1H,m), 4.00 (1H,s), 5.28-5.42 (2H,m), 6.18-6.24 (1H,m), 6.85-6.94 (1H,m), 7.42-7.52 (1H,m) Example 36 Preparation of N-(3-(Oleoylaminopropyl)-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide Acetic anhydride (10 ml) was added to a solution N-(3-Oleoylaminopropyl)-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide (0.54 g) in 5 ml of pyridine was stirred for 15 hours. The solvent was then distilled off under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 0.62 g of the refined title compound (yield: 99%). Property: Oily IR(cm⁻¹, neat): νC=O 1738, 1658 Mass Spectrometric Analysis: Molecular Formula C₃₄H₆₁N₃O₇ Calculated 623.4508 Found 623.4499 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.04 (3H,s), 1.08 (3H,s), 1.16-1.50 (23H,m), 1.56-1.72 (2H,m), 1.90-2.06 (2H,m), 2.07 (3H,s), 2.15 (3H,s), 2.19 (2H,t,J =7Hz), 2.46 (2H,t,J=6Hz), 2.32-2.48 (2H,m), 3.16-3.40 (5H,m), 3.48-3.62 (2H,m), 3.86 (1H,d,J=11Hz), 4.03 (1H,s), 4.90 (1H,s), 5.28-5.40 (2H,m), 5.59-6.06 (1H,m), 6.60-6.70 (1H,m), 7.18-7.28 (1H,m) Example 37 Preparation of N-(4-Oleoylaminobutyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4 carbonyl)amino]propanamide N-(4-Aminobutyl)oleamide (3.77 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 2.66 g of the title compound (yield: 45%). Property: Oily IR(cm⁻¹, neat): νC=O 1648 Mass Spectrometric Analysis: Molecular Formula C₃₄H₆₃N₃O₅ Calculated 593.4768 Found 539.4797 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.20-1.40 (18H,m), 1.43 (3H,s), 1.46 (3H,s), 1.50-1.70 (6H,m), 1.86-2.10 (6H,m), 2.16 (2H,t,J =8Hz), 2.45 (2H,t,J=6Hz), 3.20-3.32 (5H,m), 3.20-3.32 (5H,m), 3.42-3.66 (2H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 5.26-5.42 (2H,m), 5.78-5.86 (1H,m), 6.35-6.45 (1H,m), 7.20-7.12 (1H,m) Example 38 Preparation of N-(4-Oleoylaminobutyl)-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-(4-Oleoylaminobutyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide (1.19 g) was reacted in the same manner as in Example 19 to obtain 0.43 g of the title compound (yield: 39%). property: Oily IR(cm⁻¹, neat): νC=O 1650 Mass Spectrometric Analysis: Molecular Formula C₃₁H₅₉N₃O₅ Calculated 553.4455 Found 553.4474 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.95 (3H,s), 0.99 (3H,s), 1.18-1.40 (17H,m), 1.40-1.66 (6H,m), 1.92-2.10 (4H,m), 2.18 (2H,t,J=6Hz), 2.40-2.50 (2H,m), 2.70-3.32 (6H,m), 3.32-3.72 (6H,m), 4.00 (1H,s), 5.30-5.42 (2H,m), 6.04-6.10 (1H,m), 6.60-6.70 (1H,m), 7.42-7.52 (1H,m) Example 39 Preparation of N-(4-Oleoylaminobutyl)-3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propanamide N-(4-Oleoylaminobutyl)-3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanamide (0.55 g) and 10 ml of acetic anhydride were reacted in the same manner as in Example 36 to obtain 0.52 g of the title compound (yield: 82%). property: Oily IR(cm⁻¹, neat): νC=O 1730, 1650 Mass Spectrometric Analysis: Molecular Formula C₃₅H₆₃N₃O₇ Calculated 637.4566 Found 637.4584 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.03 (3H,s), 1.07 (3H,s), 1.20-1.40 (18H,m), 1.50-1.70 (6H,m), 1.70-2.10 (6H,m), 2.07 (3H,s), 2.16 (3H,s), 2.16 (2H,t,J= 7Hz), 2.38 (2H,t,J=6Hz), 3.20-3.30 (4H,m), 3.42 -3.62 (2H,m), 3.85 (1H,d,J=11Hz), 4.20 (1H,d,J= 11Hz), 4.93 (1H,s), 5.30-5.42 (2H,m), 5.76-5.86 (1H,m), 6.22-6.30 (1H,m), 7.00-7.08 (1H,m) Example 40 Preparation of N-(5-Oleoylaminopentyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(5-Aminopentyl)oleamide (3.66 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 3.64 g of the title compound (yield: 60%). property: Oily IR(cm⁻¹, neat): νC=O 1660 Mass Spectrometric Analysis: Molecular Formula C₃₅H₆₅N₃O₅ Calculated 607.4923 Found 607.4906 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.20-1.74 (30H,m), 1.46 (3H,s), 1.48 (3H,s), 1.90-2.10 (4H,m), 2.16 (2H,t,J=7Hz), 2.44 (2H,t,J=7Hz), 3.24 (2H,dt,J=6Hz,7Hz), 3.29 (1H,d,J=12Hz), 3.44-3.665 (2H,m), 3.68 (1H,d,J =12Hz), 4.07 (1H,s), 5.32-5.44 (2H,m), 5.44-5.62 (1H,m), 6.05-6.12 (1H,m) 6.96-7.08 (1H,m) Example 41 Preparation of N-(6-Oleoylaminohexyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(6-Aminohexyl)oleamide (3.81 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 2.92 g of the title compound (yield: 47%). property: Oily IR(cm⁻¹, neat): νC=O 1664, 1644 Mass Spectrometric Analysis: Molecular Formula C₃₆H₆₇N₃O₅ Calculated 621.5080 Found 621.5057 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.18-1.76 (32H,m), 1.42 (3H,s), 1.46 (3H,s), 1.92-2.10 (4H,m), 2.15 (2H,t,J=7Hz), 2.44 (2H,t,J=7Hz), 3.23 (2H,dt,J=6Hz,7Hz), 3.29 (1H,d,J=12Hz), 2.44-3.66 (4H,m), 3.68 (1H,d,J =12Hz), 4.07 (1H,s), 5.30-5.42 (2H,m), 5.48-5.58 (1H,m), 5.96-6.06 (1H,m), 7.00-7.06 (1H,m) Example 42 Preparation of N-(8-Oleoylaminooctyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide N-(8-Aminooctyl)oleamide (4.08 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 1.36 g of the title compound (yield: 21%). property: Oily IR(cm⁻¹, neat): νC=O 1664, 1644 Mass Spectrometric Analysis: Molecular Formula C₃₈H₇₁N₃O₅ Calculated 649.5392 Found 649.53886 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.20-1.40 (27H,m), 1.42 (3H,s), 1.46 (3H,s), 1.56-1.72 (4H,m), 1.92-2.10 (4H,m), 2.15 (2H,t,J=7Hz), 2.43 (2H,t,J=7Hz), 3.18-3.26 (5H,m), 3.28 (1H,d,J=12Hz), 3.44-3.66 (4H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 5.30-5.40 (2H,m), 5.40-5.48 (1H,m), 5.86-5.94 (1H,m), 6.98-7.06 (1H,m) Example 43 Preparation of N-(2-Oleoyloxyethyl)-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 2-Aminoethyl oleate (3.26 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 1 to obtain 1.75 g of the title compound (yield: 31%). property: Oily IR(cm⁻¹, neat): νC=O 1742, 1660 Mass Spectrometric Analysis: Molecular Formula C₃₂H₅₈N₂O₆ Calculated 566.4294 Found 566.4304 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.16-1.40 (H,m), 1.42 (3H,s), 1.46 (3H,s), 1.52-1.70 (4H,m), 1.70-1.90 (2H,m), 1.96-2.08 (2H,m), 2.32 (2H,t,J=7Hz), 2.46 (2H,t,J=7Hz), 3.29 (1H,d,J=12Hz), 3.42-3.66 (4H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 4.15 (2H,t,J =12Hz), 5.32-5.40 (2H,m), 6.08-6.18 (1H,m), 6.98-7.08 (1H,m) Example 44 Preparation of 2-(N-Oleoylamino)ethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(2-Hydroxyethyl)oleamide (0.97 g) and 0.78 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 1.50 g of the title compound (yield: 90%). property: Oily IR(cm⁻¹, neat): νC=O 1742, 1658 Mass Spectrometric Analysis: Molecular Formula C₃₂H₅₈N₂O₆ Calculated 566.4254 Found 566.4274 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.03 (3H,s), 1.22-1.38 (18H,m), 1.43 (3H,s), 1.47 (3H,s), 1.50-1.72 (5H,m), 1.92-2.08 (4H,m), 2.21 (2H,t,J=7Hz), 2.56 (2H,t,J=6Hz), 3.29 (1H,d,J= 12Hz), 3.42-3.70 (4H,m), 3.66 (1H,d,J=12Hz), 4.08 (1H,s), 4.18 (1H,s), 5.28-5.40 (2H,m), 6.27-6.38 (1H,brs), 6.88-6.96 (1H,brs) Example 45 Preparation of 2-(N-Oleoylamino)ethyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate 2-(N-oleoyl)amino)ethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (880 mg) was reacted in the same manner as in Example 19 to obtain 740 mg of the title compound (yield: 91%). property: Oily IR(cm⁻¹, neat): νNH 3324, νC=O 1740, 1650 Mass Spectrometric Analysis: Molecular Formula C₂₉H₅₄N₂O₆ Calculated 526.3952 Found 526.3961 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.94 (3H,s), 1.04 (3H,s), 1.20-1.40 (20H,m), 1.52-1.68 (2H,m), 1.90-2.10 (3H,m), 2.20 (2H,t,J=7Hz), 2.49-2.58 (2H,m), 2.80-3.20 (3H,m), 3.38-3.76 (6H,m), 4.02 (1H,s), 4.05-5.42 (2H,m), 6.20-6.30 (1H,brs), 7.30-7.40 (1H,brs) Example 46 Preparation of 2-(N-Methyl-N-oleoylamino)ethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-Methyl-(2-hydroxyethyl)oleamide (3.40 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 3.42 g of the title compound (yield: 59%). property: Oily IR(cm⁻¹, neat): νC=O 1740, 1658 Mass Spectrometric Analysis: Molecular Formula C₃₃H₆₀N₂O₆ Calculated 580.4452 Found 580.4478 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.22-1.42 (19H,m), 1.43 (3H,s), 1.47 (3H,s), 1.55-1.70 (3H,m), 1.90-2.10 (4H,m), 2.30 (2H,tt,J=7Hz,7Hz), 2.52-2.60 (2H,m), 3.05 (3H,s), 3.29 (1H,d,J=12Hz), 3.42-3.60 (4H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.24 (2H,t,J= 7Hz), 5.30-5.42 (2H,m), 6.98-7.08 (1H,m) Example 47 Preparation of 3-(N-oleoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-hydroxyethyl)oleamide (3.40 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 4.52 g of the title compound (yield: 59%). property: Oily IR(cm⁻¹, neat): νC=O 1740, 1654 Mass Spectrometric Analysis: Molecular Formula C₃₃H₆₀N₂O₆ Calculated 580.4450 Found 580.4449 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.10-1.50 (21H,m), 1.43 (3H,s), 1.46 (3H,s), 1.52-1.86 (2H,m), 1.84 (2H,tt,J=6Hz,7Hz), 1.90-2.10 (3H,m), 2.17 (2H,t,J=7Hz), 2.56 (1H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.33 (2H,dd,J=6Hz,7Hz), 3.35-3.60 (2H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.15 (2H,t,J= 7Hz), 5.28-5.42 (2H,m), 5.92-6.02 (1H,brs), 6.90-7.00 (1H,brs) Example 48 Preparation of 3-(N-oleoylamino)propyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-4-oxobutyl)amino]propionate 3-(N-Oleoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (0.58 g) was reacted in the same manner as in Example 19 to obtain 0.49 g of the title compound (yield: 90%). property: Oily IR(cm⁻¹, neat): νC=O 1740, 1652 Mass Spectrometric Analysis: Molecular Formula C₃₀H₅₆N₂O₆ Calculated 540.4145 Found 540.4138 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.93 (3H,s), 1.04 (3H,s), 1.18-1.40 (19H,m), 1.52-1.66 (2H,m), 1.83 (2H,tt,J=6Hz,7Hz), 1.92-2.06 (4H,m), 2.19 (2H,t,J=6Hz), 2.46-2.72 (2H,m), 3.00-3.56 (8H,m), 3.64-3.76 (1H,m), 3.98-4.10 (1H,m), 4.03 (1H,s), 4.19-4.30 (1H,m), 5.28-5.42 (2H,m), 5.86-5.98 (1H,m), 7.44-7.52 (1H,m) Example 49 Preparation of 3-(N-Oleoylamino)propyl 3-[N-(2,4-diacetoxy-3,3-dimethyl-4-oxobutyl)amino]propionate 3-(N-Oleoylamino)propyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate (540 mg) and 10 ml of acetic anhydride were reacted in the same manner as in Example 36 to obtain 500 mg of the title compound (yield: 80%). property: Oily IR(cm⁻¹, neat): νC=O 1740, 1650 Mass Spectrometric Analysis: Molecular Formula C₃₄H₆₀N₂O₈ Calculated 624.4348 Found 624.4323 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.04 (3H,s), 1.07 (3H,s), 1.15-1.40 (21H,m), 1.55-1.72 (2H,m), 1.84 (2H,tt,J=6Hz,6Hz), 1.92-2.10 (3H,m), 2.07 (3H,s), 2.15 (3H,s), 2.16 (2H,t,J=7Hz), 2.54 (2H,t,J=6Hz), 3.20-3.68 (4H,m), 3.83 (1H,d,J=11Hz), 4.09 (1H,d,J=11Hz), 4.12 (2H,d,J=6Hz), 4.93 (1H,s), 5.30-5.38 (2H,m), 5.92-6.02 (1H,m), 6.70-6.80 (1H,m) Example 50 Preparation of 3-(N-Oleoylamino)propyl 3-[N-(2,4-dibenzoyloxy-3,3-dimethyl-4-oxobutyl)amino]propionate 3-(N-Oleoylamino)propyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate (270 mg) and 281 mg of benzoyl chloride were reacted in the same manner as in Example 36 to obtain 260 mg of the title compound (yield: 69%). property: Oily IR(cm⁻¹, neat): νC=O 1722, 1650 Mass Spectrometric Analysis: Molecular Formula C₄₄H₆₄N₂O₈ Calculated 748.4662 Found 748.4673 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.20-1.40 (25H,m), 1.52-1.64 (2H,m), 1.76 (2H,tt,J=6Hz,6Hz), 1.94-2.06 (4H,m), 2.11 (2H,t,J=7Hz), 2.51 (2H,t,J=6Hz), 3.18-3.40 (2H,m), 3.40-3.66 (2H,m), 4.02 (2H,t,J=6Hz), 4.28 (1H,d,J=10Hz), 4.33 (1H,d,J=10Hz), 5.30-5.40 (2H,m), 5.82-5.92 (1H,m), 6.78-6.86 (1H,m), 7.40-7.50 (4H,m), 7.52-7.64 (2H,m), 8.00-8.10 (4H,m) Example 51 Preparation of 3-(N-Oleoylamino)propyl 3-[N-(4-benzoyloxy-2-hydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate 3-(N-Oleoylamino)propyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate (540 mg) and 140 mg of benzoyl chloride were reacted in the same manner as in Example 36 to obtain 318 mg of the title compound (yield: 51%). property: Oily IR(cm⁻¹, neat): νC=O 1740, 1720, 1660 Mass Spectrometric Analysis: Molecular Formula C₃₇H₆₀N₂O₆ Calculated 628.4449 Found 628.4423 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.06 (3H,s), 1.18 (3H,s), 1.16-1.40 (17H,m), 1.48-1.62 (2H,m), 1.62-1.70 (3H,m), 1.81 (2H,tt,J=7Hz,7Hz), 1.92-2.08 (3H,m), 2.11 (3H,t,J=7Hz), 2.42-2.70 (2H,m), 3.18-3.30 (1H,m), 3.34-3.48 (2H,m), 3.64-3.76 (1H,m), 4.00-4.05 (2H,m), 4.12 (1H,d,J=12Hz), 4.14-4.24 (1H,m), 4.38 (1H,t,J=12Hz), 4.64-4.68 (1H,brs), 5.28-5.40 (2H,m), 5.72-5,82 (1H,brs), 7.30-7.38 (1H,m), 7.44 (2H,dd,J=7Hz,7Hz), 7.56 (1H,dd,J=7Hz,7Hz), 8.05 (2H,d,J=7Hz) Example 52 Preparation of 3-(N-Oleoylamino)propyl 3-[N-(2-phenyl-5,5-dimethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-hydroxypropyl)oleamide (3.40 g) and 3.07 g of 3-[N-(2-phenyl-5,5-dimethyl-1,3-dioxane-4-carbonyl)amino]propionic acd were reacted in the same manner as in Example 15 to obtain 5.34 g of the title compound (yield: 85%). property: Oily IR(cm⁻¹, neat): νC=O 1738, 1662 Mass Spectrometric Analysis: Molecular Formula C₃₇H₆₀N₂O₆ Calculated 628.4452 Found 628.4465 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.11 (3H,s), 1.20 (3H,s), 1.22-1.43 (13H,m), 1.52-1.72 (6H,m), 1.77 (2H,tt,J=7Hz,7Hz), 1.90-2.06 (4H,m), 2.14 (2H,tt,J=7Hz,7Hz), 2.38 (2H,t,J=7Hz), 2.52 (2H,t,J=7Hz), 3.26 (1H,dt,J=6Hz,7Hz), 3.46-3.62 (4H,m), 3.69 (1H,d,J=12Hz), 4.10 (1H,t,J=7Hz), 4.11 (1H,s), 5.30-5.42 (2H,m), 5.52 (1H,s), 5.82-5.92 (1H,m), 6.90-7.04 (1H,m), 7.38-7.44 (3H,m), 7.48-7.53 (2H,m) Example 53 Preparation of 3-(N-Oleoylamino)propyl 3-[N-(3,3-dimethyl-1,5-dioxaspiro[5,5]-3-carbonyl)amino]propionate N-(3-hydroxypropyl)oleamide (3.40 g) and 2.99 g of 3-[N-(3,3-dimethyl-1,5-dioxaspiro[5,5]-3-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 5.46 g of the title compound (yield: 88%). property: Oil IR(cm⁻¹, neat): νC=O 1740, 1652 Mass Spectrometric Analysis: Molecular formula C₃₆H₆₄N₂O₆ Calculated 620.4763 Found 620.4761 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.03 (3H,s), 1.22-2.10 (36H,m), 2.17 (2H,t,J=7Hz), 2.56 (2H,t,J=7Hz), 3.26 (1H,d,J=12Hz), 3.32 (2H,dt,J=6Hz,7Hz), 3.50-3.68 (4H,m), 3.71 (1H,d,J=12Hz), 4.10 (1H,s), 4.15 (2H,t,J=7Hz), 5.28-5.40 (2H,m), 5.90-5.98 (1H,m), 6.98-7.10 (1H,m) Example 54 Preparation of 3-(N-Oleoylamino)propyl 3-[N-(2-hydroxy-3,3-dimethyl-4-(pivaloyloxy-1-oxobutyl)amino]propionate 3-(N-Oleoylamino)propyl 3-[N-(2,4-dihydroxy -3,3-dimethyl-1-oxobutyl)amino]propionate (540 mg) and 220 mg of pivaloyl chloride were reacted in the same manner as in Example 36 to obtain 139 mg of the title compound (yield: 22%). property: Oil IR(cm⁻¹, neat): νC=O 1740, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.20-1.38 (25H,m), 1.57 (9H,s), 1.52-1.70 (2H,m), 1.85 (2H,tt,J=7Hz, 7Hz), 1.94-2.06 (6H,m), 2.17 (2H,t,J=7Hz), 2.56 (1H,t,J=7Hz), 3.28-3.40 (2H,m), 3.54-3.62 (2H,m), 4.07 (1H,d,J=12Hz), 4.10-4.20 (2H,m), 4.68 (1H,d,J=12Hz), 5.11 (1H,S), 5.28-5.40 (2H,m), 5.70-5.80 (1H,m), 6.94-7.02 (1H,m) Example 55 Preparation of 3-(N-Hexanoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)hexamide (1.75 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 1.90 g of the title compound (yield: 46%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1658 Mass Spectrometric Analysis Molecular Formula C₂₁H₃₈N₂O₆ Calculated 414.2730 Found 414.2741 NMR(δ, CDCl₃): 0.90 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.22-1.36 (3H,m), 1.43 (3H,s), 1.46 (3H,s), 1.58-1.74 (1H,m), 1.85 (2H,tt,J=7Hz,7Hz), 2.18 (2H,t,J=7Hz), 2.56 (2H,t,J=7Hz), 3.29 (1H,d,J =12Hz), 3.33 (2H,dt,J=6Hz,7Hz), 3.46-3.66 (4H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.16 (2H,t,J=12Hz), 5.94-6.02 (1H,m), 6.92-7.04 (1H,m) Example 56 Prepartion of 3-(N-Octanoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)octamide (2.03g) and 2.56 g of 3-[N-(2,2,5,5-tetramethyl)-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 2.91 g of the title compound (yield: 66%) Property: Oily IR(cm⁻¹, neat): ν C=O 1738, 1658 Mass Spectrometric Analysis Molecular Formula C₂₃H₄₂N₂O₆ Calculated 442.3043 Found 442.3054 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.20-1.36 (5H,m), 1.42 (3H,s), 1.46 (3H,s), 1.56-1.74 (3H,m), 1.84 (2H,tt,J=7Hz,7Hz), 2.17 (2H,t,J=7Hz), 2.56 (2H,t,J=7Hz), 3.29 (1H,d,J =12Hz), 3.33 (2H,dt,J=6Hz,7Hz), 3.46-3.66 (4H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.15 (2H,t,J=7Hz), 5.94-6.02 (1H,m), 6.92-7.04 (1H,m) Example 57 Preparation of 3-(N-Decanoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)decanamide (2.29 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 4.61 g of the title compound (yield: 98%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1662 Mass Spectrometric Analysis Molecular Formula C₂₅H₄₆N₂O₆ Calculated 470.3356 Found 470.3377 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.20-1.34 (6H,m), 1.42 (3H,s), 1.46 (3H,s), 1.56-1.78 (4H,m), 1.82-1.94 (3H,m), 2.17 (2H,t,J=7Hz), 2.36-2.44 (1H,m), 2.56 (2H,t,J= 7Hz), 3.29 (1H,d,J=12Hz), 3.33 (2H,dt,J= 6Hz,7Hz), 3.46-3.66 (4H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.15 (2H,t,J=12Hz), 5.92-6.02 (1H,m), 6.08-6.18 (1H,m), 6.92-7.07 (1H,m) Example 58 Preparation of 3-(N-Dodecanoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)dodecanamide (2.57 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 3.19 g of the title compound (yield: 64%) Property: Oily IR(cm⁻¹, neat): ν C=O 1738, 1660 Mass Spectrometric Analysis Molecular Formula C₂₇H₅₀N₂O₆ Calculated 498.3668 Found 498.3676 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.97 (3H,s), 1.03 (3H,s), 1.18-1.36 (7H,m), 1.41 (3H,s), 1.45 (3H,s), 1.56-1.76 (6H,m), 1.78-1.94 (4H,m), 2.16 (2H,t,J=7Hz), 2.36-2.42 (2H,m), 2.55 (2H,t,J= 7Hz), 3.28 (1H,d,J=7Hz), 3.31 (2H,dt,J= 6Hz,7Hz), 3.44-3.65 (4H,m), 3.67 (1H,d,J=12Hz), 4.06 (1H,s), 4.14 (2H,t,J=7Hz), 5.96-6.02 (1H,m), 6.90-7.04 (1H,m) Example 59 Preparation of 3-(N-Tetradecanoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)tetradecanamide (2.87 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 4.63 g of the title compound (yield: 88%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1656 Mass Spectrometric Analysis Molecular Formula C₂₉H₅₄N₂O₆ Calculated 526.3981 Found 526.3983 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.20-1.34 (15H,m), 1.42 (3H,s), 1.46 (3H,s), 1.52-1.64 (4H,m), 1.84 (2H,tt,J=7Hz,7Hz), 2.17 (2H,t,J=7Hz), 2.36-2.44 (1H,m), 2.56 (2H,t,J= 7Hz), 3.29 (1H,d,J=12Hz), 3.33 (2H,dt,J= 6Hz,7Hz), 3.48-3.66 (4H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.16 (2H,t,J=7Hz), 5.92-5.96 (1H,m), 6.90-7.02 (1H,m) Example 60 Preparation of 3-(N-Hexadecanoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)hexadecanamide (3.13 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 5.48 g of the title compound (yield: 99%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1658 Mass Spectrometric Analysis Molecular Formula C₃₁H₅₈N₂O₆ Calculated 554.4294 Found 554.4301 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.21-1.36 (22H,m), 1.43 (3H,s), 1.46 (3H,s), 1.56-1.98 (6H,m), 1.84 (2H,tt,J=7Hz,7Hz), 2.17 (2H,t,J=7Hz), 2.56 (2H,t,J=7Hz), 3.29 (1H,d,J= 12Hz), 3.32 (2H,dt,J=6Hz,7Hz), 3.67 (2H,d,J= 12Hz), 4.08 (1H,s), 4.16 (2H,t,J=12Hz), 5.92-5.98 (1H,m), 6.92-7.04 (1H,m) Example 61 Preparation of 3-(N-Octadecanoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)otadecanamide (3.42 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 3.90 g of the title compound (yield: 67%) Property: Oily IR(cm⁻¹, neat): ν C=O 1738, 1652 Mass Spectrometric Analysis Molecular Formula C₃₃H₆₂N₂O₆ Calculated 582,4608 Found 582,4619 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.20-1.36 (17H,m), 1.42 (3H,s), 1.46 (3H,s), 1.54-1.96 (10H,m), 2.17 (3H,t,J=7Hz), 2.56 (2H,t,J=7Hz), 3.28 (1H,t,J=12Hz), 3.33 (2H,dt,J=6Hz,7Hz), 3.44-3.62 (4H,m), 3.67 (1H,d,J=12Hz), 4.08 (1H,s), 4.16 (2H,t,J=7Hz), 5.96-6.02 (1H,m), 6.92-7.04 (1H,m) Example 62 Preparation of 3-(N-Linoleoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)linoleamide (3.38 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain of the title compound (yield: 67%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1654 Mass Spectrometric Analysis Molecular Formula C₃₃H₅₈N₂O₆ Calculated 578.4294 Found 578.4291 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.20-1.44 (17H,m), 1.43 (3H,s), 1.46 (3H,s), 1.52-1.76 (4H,m), 1.84 (2H,tt,J=7Hz,7Hz), 2.00 -2.10 (6H,m), 2.17 (2H,t,J=7Hz), 2.36-2.44 (1H,m), 2.56 (2H,t,J=7Hz), 2.77 (2H,t,J=7Hz), 3.29 (1H,d,J=12Hz), 3.32 (2H,dd,J=6Hz,7Hz), 3.46-3.64 (4H,m), 3.67 (1H,d,J=12Hz), 4.08 (1H,s), 4.16 (2H,t,J=12Hz), 5.28-5.42 (4H,m), 5.92-6.00 (1H,m), 6.94-7.02 (1H,m) Example 63 Preparation of 3-(N-Linolenoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(3-Hydroxypropyl)linolenamide (3.35 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 4.09 g of the title compound (yield: 67%) Property: Oily IR(cm⁻¹, neat): ν C=O 1738, 1652 Mass Spectrometric Analysis Molecular Formula C₃₃H₅₆N₂O₆ Calculated 576.4138 Found 576.4126 NMR(δ, CDCl₃): 0.97 (3H,t,J=7Hz), 0.98 (3H,s), 1.05 (3H,s), 1.26-1.44 (12H,m), 1.43 (3H,s), 1.46 (3H,s), 1.58-1.74 (6H,m), 1.80-1.92 (4H,m), 2.02-2.10 (2H,m), 2.17 (2H,t,J=7Hz), 2.34-2.42 (2H,m), 2.56 (2H,t,J=7Hz), 3.29 (1H,d,J=12Hz), 2.74-2.86 (2H,m), 3.28 (1H,d,J=12Hz), 3.32 (2H,dd,J=6Hz,7Hz), 3.42-3.66 (4H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 4.15 (2H,t,J=12Hz), 5.26-5.44 (6H,m), 5.90-6.00 (1H,m), 6.92-7.06 (1H,m) Example 64 Preparation of 4-(N-Oleoylamino)butyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(4-Hydroxybutyl)oleamide (3.54 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 5.05 g of the title compound (yield: 85%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1662 Mass Spectrometric Analysis Molecular Formula C₃₄H₆₂N₂O₆ Calculated 594.4608 Found 594.4618 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.20-1.40 (23H,m), 1.43 (3H,s), 1.47 (3H,s), 1.50-1.80 (6H,m), 1.86-2.10 (3H,m), 2.17 (2H,dt,J=6Hz,7Hz), 2.56 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.40-3.66 (2H,m), 3.69 (1H,d,J= 12Hz), 4.08 (1H,s), 4.12 (2H,t,J=6Hz), 5.30-5.40 (2H,m), 5.48-5.56 (1H,m), 6.90-7.00 (1H,m) Example 65 Preparation of 4-(N-Oleoylamino)propyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate 4-(N-Oeloylamino)butyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (0.59 g) was reacted in the same manner as in Example 19 to obtain 0.50 g of the title compound (yield: 91%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1658 Mass Spectrometric Analysis Molecular Formula C₃₁H₅₈N₂O₆ Calculated 554.4293 Found 554.4291 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.94 (3H,s), 1.01 (3H,s), 1.18-1.42 (21H,m), 1.50-1.80 (6H,m), 1.90-2.12 (3H,m), 2.18 (1H,d,J=7Hz), 2.45-2.57 (2H,m), 3.10-3.80 (8H,m), 4.02 (1H,m), 4.05-4.13 (1H,m), 4.18-4.26 (1H,m), 5.30-5.41 (2H,m), 5.88-5.96 (1H,m), 7.34-7.44 (1H,m) Example 66 Preparation of 5-(N-Oleoylamino)propyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(5-Hydroxypentyl)oleamide (3.68 g) and 2.59 of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 4.99 g of the title compound (yield: 82%) Property: Oily IR(cm⁻¹, neat): ν C=O 1738, 1658 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₄N₂O₆ Calculated 608.4764 Found 608.4764 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.20-1.80 (26H,m), 1.42 (3H,s), 1.46 (3H,s), 1.84-2.10 (4H,m), 2.15 (2H,t,J=6Hz), 2.56 (2H,t,J=6Hz), 3.25 (1H,dt,J=6Hz,6Hz), 3.29 (1H,d,J=12Hz), 3.40-3.68 (4H,m), 3.68 (1H,d,J= 12Hz), 4.08 (1H,s), 4.10 (2H,t,J=12Hz), 5.30-5.40 (2H,m), 5.48-5.54 (1H,m), 6.90-7.02 (1H,m) Example 67 Preparation of 6-(N-Oleoylamino)hexyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate N-(6-Hydroxyhexyl)oleamide (3.82 g) and 2.59 of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 2.80 g of the title compound (yield: 45%) Property: Oily IR(cm⁻¹, neat): ν C=O 1740, 1656 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₆N₂O₆ Calculated 622.4920 Found 622.4923 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.20-1.54 (24H,m), 1.43 (3H,s), 1.47 (3H,s), 1.56-1.70 (6H,m), 1.90-2.10 (4H,m), 2.15 (2H,t,J=6Hz), 2.55 (2H,t,J=6Hz), 3.24 (2H,dt,J =6Hz,6Hz), 3.29 (1H,d,J=12Hz), 3.40-3.66 (2H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.09 (2H,t,J=6Hz), 5.30-5.40 (2H,m), 5.40-5.50 (1H,m), 6.92-7.02 (1H,m) Example 68 Preparation of S-2-(N-Oleoylamino)ethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanethionate N-(2-Mercaptoethyl)oleamide (3.42 g) and 2.59 of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 4.77 g of the title compound (yield: 82%) Property: Oily IR(cm⁻¹, neat): ν C=O 1730, 1656 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₈N₂O₅S Calculated 582.4123 Found 582.4095 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.20-1.40 (19H,m), 1.43 (3H,s), 1.47 (3H,s), 1.58-1.70 (2H,m), 1.84-2.10 (4H,m), 2.17 (2H,t,J=7Hz), 2.78-2.86 (2H,m), 3.05 (2H,t,J= 6Hz), 3.29 (1H,dt,J=12Hz), 3.35-3.62 (5H,m), 3.67 (1H,d,J=12Hz), 4.07 (1H,s), 5.34-5.41 (2H,m), 5.93-6.02 (1H,m), 6.83-6.92 (1H,m) Example 69 Preparation of S-2-(N-Oleoylamino)ethyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)aminopropanethionate S-2-(N-Oleoylamino)ethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanethionate (0.58 g) was reacted in the same manner as in Example 19 to obtain 0.16 g of the title compound (yield: 29%) Property: Oily IR(cm⁻¹, neat): ν C=O 1650 Mass Spectrometric Analysis Molecular Formula C₂₉H₅₄N₂O₅S Calculated 542.3753 Found 542.3765 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.93 (3H,s), 1.04 (3H,s), 1.15-1.40 (16H,m), 1.50-1.70 (2H,m), 1.90-2.06 (4H,m), 2.17 (2H,t,J=8Hz), 2.25-2.60 (6H,m), 2.70-2.80 (1H,m), 2.82-2.98 (2H,m), 3.05-3.15 (1H,m), 3.30-3.75 6H,m), 4.01 (1H,s), 5.30-5.42 (2H,m), 5.90-6.00 (1H,brs), 7.22-7.32 (1H,brs) Example 70 Preparation of N-[(1S,2S)-2-(Oleoylamino)cyclohexane]-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanamide 3-N-(2,2,5,5-Tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid (745 mg) and 800 mg of N-(2-aminocyclohexyl)-oleamide were reacted in the same manner as in Example 1 to obtain 504 mg of the title compound (yield: 34%) Property: Oily Specific Rotary Power [α] D : -15.1°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1662, 1642 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₅N₃O₅ Calculated 619.4924 Found 619.4913 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.15-1.37 (24H,m), 1.43 (3H,s), 1.46 (3H,s), 1.50-1.62 (2H,m), 1.68-1.82 (2H,m), 1.90-2.08 (6H,m), 2.11 (2H,t,J=7Hz), 2.28-2.44 (2H,m), 3.28 (1H,d,J=12Hz), 3.36-3.48 (1H,m), 3.55-3.68 (3H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,d,J=11Hz), 5.29-5.40 (2H,m), 5.84 (1H,brs), 6.38 (1H,brs), 7.00 (1H,t,J=6Hz) Example 71 Preparation of N-[(1S,2S)-2-(Oleoylamino)cyclohexane]-3-[(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl] amino]propanamide 3-N-[(2R)-2,4-Diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propionic acid (187 mg) and 1.72 mg of (1S,2S)-N-(2-aminocyclohexyl)oleamide were reacted in the same manner as in Example 1 to obtain 194 mg of the title compound (yield: 56%) Property: Oily Specific Rotary Power [α] D : -3.10°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1750, 1660 Mass Spectrometric Analysis Molecular Formula C₃₇H₆₅N₃O₇ Calculated 663.4822 Found 663.4833 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.03 (3H,s), 1.08 (3H,s), 1.18-1.39 (24H,m), 1.07-1.83 (2H,m), 1.92-2.09 (6H,m), 2.08 (3H,s), 2.14 (2H,t,J=7Hz), 2.20 (3H,s), 2.32 (2H,t,J=7Hz), 3.28-3.40 (1H,m), 3.49-3.59 (2H,m), 3.61-3.74 (1H,m), 3.82 (1H,d,J=12Hz), 4.04 (1H,d,J=11Hz), 4.09 (1H,s), 5.29-5.40 (2H,m), 5.79 (1H,d,J=8Hz), 6.19 (1H,d,J=8Hz), 7.03 (1H,t,J=6Hz) Example 72 Preparation of N-[2-(Oleoylamino)cyclohexane]-3-[(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl] amino]propanamide 3-N-[(2,4-Diacetoxy-3,3-dimethyl-1-oxo-butyl]amino]propionic acid (1.01 g) and 1.26 g of N-(2-aminocyclohexyl)oleamide were reacted in the same manner as in Example 1. The crude products was purified by silica gel column chromatography to obtain two diastereomers of the title compound, i.e., diastereomer A: N-[(1R,2R)-2-(oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide in an amount of 603 mg (yield: 28%) and diastereomer B: N-[(1S,2S)-2-(oleoylamino)cyclo-hexane-1-yl]-3-[N-[(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide in an amount of 714 mg (yield: 33%) A Property: Oily Specific Rotary Power [α] D : -32.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1750, 1660 Mass Spectrometric Analysis Molecular Formula C₃₇H₆₅N₃O₇ Calculated 663.4822 Found 663.4834 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.08 (3H,s), 1.10 (3H,s), 1.21-1.38 (24H,m), 1.46-1.65 (2H,m), 1.69-1.79 (2H,m), 1.88-2.08 (6H,m), 2.08 (3H,s), 2.13 (2H,t,J=7Hz), 2.14-2.26 (1H,m), 2.16 (3H,s), 2.23-2.42 (1H,m), 3.06-3.16 (1H,m), 3.56-3.79 (3H,m), 3.90 (1H,d,J=11Hz), 4.07 (1H,d,J=11Hz), 4.80 (1H,s), 5.29-5.42 (1H,m), 5.69 (1H,d,J=8Hz), 6.56 (1H,d,J=8Hz), 7.41 (1H,t,J=6Hz) B Property: Oily Specific Rotary Power [α] D : -3.10°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1750, 1660 Mass Spectrometric Analysis Molecular Formula C₃₇H₆₅N₃O₇ Calculated 663.4822 Found 663.4833 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.03 (3H,s), 1.08 (3H,s), 1.18-1.39 (24H,m), 1.07-1.83 (2H,m), 1.92-2.09 (6H,m), 2.08 (3H,s), 2.14 (2H,t,J=7Hz), 2.20 (3H,s), 2.32 (2H,t,J=7Hz), 3.28-3.40 (1H,m), 3.49-3.59 (2H,m), 3.61-3.74 (1H,m), 3.82 (1H,d,J=12Hz), 4.04 (1H,d,J=12Hz), 4.09 (1H,s), 5.29-5.40 (2H,m), 5.79 (1H,d,J=8Hz), 6.19 (1H,d,J=8Hz), 7.03 (1H,t,J=6Hz) Example 73 Preparation of N-[(1R,2R)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]amino]propanamide N-[(1R,2R)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-diaceotxy-3,3-dimethyl-1-oxobutyl]amino]propanamide (380 mg) was reacted in the same manner as in Example 3 to obtain 293 mg of the title compound (yield: 89%) Property: Oily Specific Rotary Power [α] D : +34.1°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1642 Mass Spectrometric Analysis Molecular Formula C₃₃H₆₁N₃O₅ Calculated 579.4611 Found 579.4596 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.95 (3H,s), 1.04 (3H,s), 1.17-1.38 (24H,m), 1.49-1.62 (2H,m), 1.73-1.82 (2H,m), 1.93-2.08 (6H,m), 2.14 (2H,t,J=7Hz), 3.31-2.45 (2H,m), 2.52-2.86 (2H,m), 3.44-3.73 (6H,m), 3.98 (1H,s), 5.28-5.40 (2H,m), 6.08 (1H,brs), 6.63 (1H,brs), 7.34 (1H,t,J=6Hz) Example 74 Preparation of N-[(1S,2S)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]amino]propanamide N-[(1S,2S)-2-(Oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-diaceotxy-3,3-dimethyl-1-oxobutyl]amino]propanamide (485 mg) was reacted in the same manner as in Example 3 to obtain 410 mg of the title compound (yield: 97%) Property: Oily Specific Rotary Power [α] D : -0.60°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1644 Mass Spectrometric Analysis Molecular Formula C₃₃H₆₁N₃O₅ Calculated 579.4611 Found 579.4603 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.94 (3H,s), 1.05 (3H,s), 1.16-1.38 (24H,m), 1.46-1.62 (2H,m), 1.71-1.82 (2H,m), 1.87-2.07 (6H,m), 2.12 (2H,t,J=7Hz), 2.32-2.44 (1H,m), 2.48-2.58 (1H,m), 2.63-3.05 (2H,m), 3.18-3.29 (1H,m), 3.46 (2H,d,J=11Hz), 3.51 (2H,d,J=11Hz), 3.86-3.99 (1H,m), 4.12 (1H,s), 5.29-5.41 (2H,m), 5.99 (1H,d,J=8Hz), 7.02 (1H,d,J=8Hz), 7.11-7.19 (1H,m) Example 75 Preparation of N-[2-(Oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide dl-3-[N-2,4-Diaceotxy-3,3-dimethyl-1-oxobutyl]amino]propionic (1.51 g) and 1.90 g of (1R,2R)-N-(2-aminocyclohexyl)oleamide were reacted in the same manner as in Example 1. The crude products was purified by silica gel column chromatography to obtain two diastereomers of the title compound, diastereomer A: N-(1R,2R)-2-(oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide in an amount of 0.848 g (yield: 28%) and diastereomer B: N-[(1R,2R)-2-(oleoylamino)cyclo-hexane-1-yl]-3-[N-[(2S)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide in an amount of 1.00 g (yield: 33%) A Property: Oily Specific Rotary Power [α] D : -32.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1750, 1660 Mass Spectrometric Analysis Molecular Formula C₃₇H₆₅N₃O₇ Calculated 663.4822 Found 663.4834 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.08 (3H,s), 1.10 (3H,s), 1.21-1.38 (24H,m), 1.46-1.65 (2H,m), 1.69-1.79 (2H,m), 1.88-2.08 (6H,m), 2.08 (3H,s), 2.13 (2H,t,J=7Hz), 2.14-2.26 (1H,m), 2.16 (3H,s), 2.23-2.42 (1H,m), 3.06-3.16 (1H,m), 3.56-3.79 (3H,m), 3.90 (1H,d,J=11Hz), 4.07 (1H,d,J=11Hz), 4.80 (1H,s), 5.29-5.42 (1H,m), 5.69 (1H,d,J= 8Hz), 6.56 (1H,d,J=8Hz), 7.41 (1H,t,J=6Hz) B Property: Oily Specific Rotary Power [α] D : +2.04°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1750, 1660 Mass Spectrometric Analysis Molecular Formula C₃₇H₆₅N₃O₇ Calculated 663.4822 Found 663.4833 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.03 (3H,s), 1.08 (3H,s), 1.18-1.39 (24H,m), 1.07-1.83 (2H,m), 1.92-2.09 (6H,m), 2.08 (3H,s), 2.14 (2H,t,J=7Hz), 2.20 (3H,s), 2.32 (2H,t,J=7Hz), 3.28-3.40 (1H,m), 3.49-3.59 (2H,m), 3.61-3.74 (1H,m), 3.82 (1H,d,J=12Hz), 4.04 (1H,d,J=12Hz), 4.09 (1H,s), 5.29-5.40 (2H,m), 5.79 (1H,d,J=8Hz), 6.19 (1H,d,J=8Hz), 7.03 (1H,t,J=6Hz) Example 76 Preparation of N-[2-(Oleoylamino)cyclohexane-1-yl]-3-[N-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide dl-3-[N-2,4-Diaceotxy-3,3-dimethyl-1-oxobutyl]amino]propionic (1.44 g) and 1.80 g of (1S,2S)-N-(2-aminocyclohexyl)oleamide were reacted in the same manner as in Example 1. The crude products was purified by silica gel column chromatography to obtain two diastereomers of the title compound, diastereomer A: N-[(1S,2S)-2-(oleoylamino)cyclohexane-1-yl]-3-[N-[(2R)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide in an amount of 0.859 g (yield: 29%) and diastereomer B: N-[(1S,2S)-2-(oleoylamino)cyclo-hexane-1-yl]-3-[N-[(2S)-2,4-diacetoxy-3,3-dimethyl-1-oxobutyl]amino]propanamide in an amount of 0.80 g (yield: 27%) B Property: Oily Specific Rotary Power [α] D : -32.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1750, 1660 Mass Spectrometric Analysis Molecular Formula C₃₇H₆₅N₃O₇ Calculated 663.4822 Found 663.4834 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.08 (3H,s), 1.10 (3H,s), 1.21-1.38 (24H,m), 1.46-1.65 (2H,m), 1.69-1.79 (2H,m), 1.88-2.08 (6H,m), 2.08 (3H,s), 2.13 (2H,t,J=7Hz), 2.14-2.26 (1H,m), 2.16 (3H,s), 2.23-2.42 (1H,m), 3.06-3.16 (1H,m), 3.56-3.79 (3H,m), 3.90 (1H,d,J=11Hz), 4.07 (1H,d,J=11Hz), 4.80 (1H,s), 5.29-5.42 (1H,m), 5.69 (1H,d,J= 8Hz), 6.56 (1H,d,J=8Hz), 7.41 (1H,t,J=6Hz) Example 77 Preparation of (1R,2R)-2-(Oleoylamino)cyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (1R,2R)-2-(N-Oleoylamino)cyclohexanol (3.79 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 3.52 g of the title compound (yield: 57%) Property: Oily Specific Rotary Power [α] D : +26.2°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1736, 1654 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₄N₂O₆ Calculated 620.4764 Found 620.4759 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (3H,s), 1.04 (3H,s), 1.07-1.39 (24H,m), 1.43 (3H,s), 1.48 (3H,s), 1.50-1.83 (4H,m), 1.92-2.17 (6H,m), 2.10 (2H,t,J=7Hz), 2.51 (2H,t,J=6Hz), 3.32-3.43 (1H,m), 3.57-3.68 (1H,m), 3.69 (1H,d,J=12Hz), 3.83-3.95 (1H,m), 4.08 (1H,s), 4.64 (1H,td,J= 11Hz,5Hz), 5.28-5.40 (1H,m), 5.74 (1H,d,J=8Hz), 6.95 (1H,d,J=6Hz) Example 78 Preparation of (1S,2S)-2-(Oleoylamino)cyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (1S,2S)-2-(N-Oleoylamino)cyclohexanol (3.79 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 3.52 g of the title compound (yield: 57%) Property: Oily Specific Rotary Power [α] D : +14.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1734, 1654 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₄N₂O₆ Calculation 620.4764 Found 620.4777 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.06-1.38 (24H,m), 1.43 (3H,s), 1.47 (3H,s), 1.48-1.80 (4H,m), 1.92-2.17 (6H,m), 2.10 (2H,t,J=7Hz), 2.51 (2H,t,J=6Hz), 3.28 (1H,t,J= 12Hz), 3.45-3.57 (2H,m), 3.69 (1H,d,J=12Hz), 3.82-3.93 (1H,m), 4.08 (1H,s), 4.64 (1H,td,J= 11Hz,5Hz), 5.79 (1H,d,J=8Hz), 6.91 (1H,d,J=6Hz) Example 79 Preparation of (1R,2R)-2-(Stearoylamino)cyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (1R,2R)-2-(N-Stearoylamino)cyclohexanol (3.81 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 2.82 g of the title compound (yield: 45%) Property: Oily Melting Point : 69.1 - 70.2 Specific Rotary Power [α] D : +25.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1734, 1660, 1646 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₆N₂O₆ Calculated 622.4920 Found 622.4930 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (3H,s), 1.04 (3H,s), 1.11-1.34 (32H,m), 1.43 (3H,s), 1.48 (3H,s), 1.50-1.82 (4H,m), 1.95-2.18 (2H,m), 2.10 (2H,t,J=7Hz), 2.51 (1H,t,J=6Hz), 3.29 (1H,d,J= 12Hz), 3.31-3.34 (1H,m), 3.57-3.68 (1H,m), 3.69 (1H,d,J=12Hz), 3.83-3.95 (1H,m), 4.08 (1H,s), 4.64 (1H,td,J=11Hz,5Hz), 5.74 (1H,d,J=8Hz), 6.95 (1H,d,J=6Hz) Example 80 Preparation of (1S,2S)-2-(Linoleoylamino)cyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (1S,2S)-2-(N-Linoleoylamino)cyclohexanol (3.77 g) and 2.59 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 15 to obtain 2.72 g of the title compound (yield: 44%) Property: Oily Specific Rotary Power [α] D : +13.5°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν C=O 1736, 1654 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₂N₂O₆ Calculated 618.4607 Formula 618.4612 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.11-1.39 (18H,m), 1.43 (3H,s), 1.47 (3H,s), 1.51-1.81 (4H,m), 1.95-2.18 (6H,m), 2.10 (2H,t,J=7Hz), 2.50 (2H,t,J=6Hz), 2.77 (2H,d,J= 6Hz), 3.28 (1H,d,J=12Hz), 3.46-3.57 (2H,m), 3.69 (1H,d,J=12Hz), 3.32-3.43 (1H,m), 4.09 (1H,s), 4.64 (1H,td,J=11Hz,5Hz), 5.28-5.43 (4H,m), 5.80 (1H,d,J=8Hz), 6.91 (1H,d,J=6Hz) In a similar manner as described above, the following compounds were synthesized. Example 81 (R)-1-Methyl-2-oleoylaminoethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₆₀N₂O₆ Molecular Weight 580.85 Mass Spectrometric Analysis: Calculated 580.4451 Found 580.4448 Melting Point (°C): Oil Specific Rotary Power: [α]²² D +31.1°(C=1.0, CHCl₃) IR(νneat, cm⁻¹) : 3332, 2932, 2860, 1740, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (3H,s), 1.02 (3H,s), 1.21-1.38 (23H,m), 1.43 (3H,s), 1.47 (3H,s), 1.55-1.69 (2H,m), 1.91-2.08 (4H,m), 2.28 (2H,t,J=7Hz), 2.44-2.62 (2H,m), 3.29 (1H,t,J= 12Hz), 3.30-3.53 (3H,m), 3.65-3.78 (1H,m), 3.68 (1H,d,J=12Hz), 4.07 (3H,s), 4.92-5.03 (1H,m), 5.29-5.40 (2H,m), 6.30-6.38 (1H,m), 6.91 (1H,t,J=6Hz) Example 82 (S)-1-Methyl-2-oleoylaminoethyl-3-[N-(2,2,5,5 -tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₆₀N₂O₆ Molecular Weight 580.85 Mass Spectrometric Analysis: Calculated 580.4451 Found 580.4458 Melting Point (°C): Oil Specific Rotary Power: [α]²² D +21.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3332, 2932, 2860, 1738, 1662 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.20-1.37 (23H,m), 1.43 (3H,s), 1.47 (3H,s), 1.56-1.68 (2H,m), 1.91-2.08 (4H,m), 2.20 (2H,t,J=7Hz), 2.44-2.62 (2H,m), 3.26-3.35 (1H,m), 3.28 (1H,d,J=12Hz), 3.42-3.58 (2H,m), 3.64-3.75 (1H,m), 3.70 (1H,d,J=12Hz), 4.07 (1H,s), 4.93-5.03 (1H,m), 5.28-5.41 (2H,m), 6.27-6.34 (1H,m), 6.88-6.96 (1H,m) Example 83 (1S,2S)-2-(Oleoylamino)cyclopentane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₆₂N₂O₆ Molecular Weight 606.89 Mass Spectrometric Analysis: Calculated 606.4607 Found 606.4617 Melting Point (°C): Oil Specific Rotary Power: [α]²³ D +24.5°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3324, 2932, 2860, 1736, 1654 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.20-1.48 (22H,m), 1.43 (3H,s), 1.46 (3H,s), 1.52-2.09 (9H,m), 2.13 (2H,t,J=7Hz), 2.18-2.22 (1H,m), 2.54 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.48-3.59 (2H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 4.08-4.19 (1H,m), 4.92-5.01 (1H,m), 5.29-5.40 (2H,m), 5.72 (1H,d,J=7Hz), 6.98 (1H,t,J=6Hz) Example 84 (1R,2R)-2-(Oleoylamino)cyclopentane-1-yl-3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₆₂N₂O₆ Molecular Weight 606.89 Mass Spectrometric Analysis: Calculated 606.4607 Found 606.4614 Melting Point (°C): Oil Specific Rotary Power: [α]²⁴ D +14.9°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3328, 2932, 2860, 1740, 1656 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (3H,s), 1.04 (3H,s), 1.21-1.47 (22H,m), 1.43 (3H,s), 1.46 (3H,s), 1.53-2.12 (9H,m), 2.13 (2H,t,J=7Hz), 2.18-2.31 (1H,m), 2.54 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.36-3.49 (1H,m), 3.58-3.69 (1H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 4.09-4.20 (1H,m), 4.95-5.02 (1H,m), 5.29-5.40 (2H,m), 5.72 (1H,d,J=7Hz), 7.02 (1H,t,J=6Hz) Example 85 (Z)-4-Oleoylamino-2-butenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₄H₆₀N₂O₆ Molecular Weight 592.80 Mass Spectrometric Analysis: Calculated 592.4451 Found 592.4424 Melting Point (°C): Oil Specific Rotary Power: [α]²⁴ D +22.2°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3336, 2932, 2860, 1740, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.04 (3H,s), 1.20-1.38 (20H,m), 1.43 (3H,s), 1.46 (3H,s), 1.54-1.69 (2H,m), 1.91-2.08 (4H,m), 2.17 (2H,t,J=7Hz), 2.57 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.42-3.67 (2H,m), 3.69 (1H,d,J=12Hz), 3.97 (2H,dd,J=6Hz,6Hz), 4.08 (1H,s), 4.70 (2H,d,J=6Hz), 5.29-5.40 (2H,m), 5.59-5.80 (3H,m), 6.88-6.96 (1H,m) Example 86 (R)-2-Methyl-2-oleoylaminoethyl 3-[N-(2,5,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₆₀N₂O₆ Molecular Weight 580.85 Mass Spectrometric Analysis: Calculated 580.4451 Found 580.4458 Melting Point (°C): Oil Specific Rotary Power: [α]²⁵ D +31.0°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3324, 2932, 2860, 1740, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.18 (3H,d,J=6Hz), 1.23-1.39 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.57-1.68 (2H,m), 1.92-2.08 (4H,m), 2.16 (2H,t,J=7Hz), 2.58 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.57 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 4.03-4.14 (2H,m), 4.07 (1H,s), 4.26-4.37 (1H,m), 5.29-5.40 (2H,m), 5.84 (1H,d,J=8Hz), 6.98 (1H,t,J=6Hz) Example 87 (S)-2-Methyl-2-oleoylaminoethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₆₀N₂O₆ Molecular Weight 580.85 Mass Spectrometric Analysis: Calculated 580.4451 Found 580.4442 Melting Point (°C): Oil Specific Rotary Power: [α]²⁴ D +13.1°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2860, 1744, 1654 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.03 (3H,s), 1.16 (3H,d,J=6Hz), 1.21-1.39 (20H,m), 1.42 (3H,s), 1.47 (3H,s), 1.54-1.68 (2H,m), 1.92-2.08 (4H,m), 2.17 (2H,t,J=7Hz), 2.58 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.49-3.67 (2H,m), 3.69 (1H,d,J=12Hz), 4.05 (1H,dd,J=11Hz, 4Hz), 4.07 (1H,s), 4.13 (1H,dd,J=11Hz,5Hz), 4.22-4.36 (1H,m), 5.29-5.42 (2H,m), 5.92 (1H,d,J=8Hz), 6.92 (1H,t,J=5Hz) Example 88 (E)-4-Oleoylamino-2-butenyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₄H₆₀N₂O₆ Molecular Weight 592.86 Mass Spectrometric Analysis: Calculated 592.4451 Found 592.4459 Melting Point (°C): Oil Specific Rotary Power: [α]²⁵ D +22.1°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3328, 2932, 2860, 1740, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.21-1.38 (20H,m), 1.43 (3H,s), 1.46 (3H,s), 1.56-1.69 (2H,m), 1.91-2.08 (4H,m), 2.18 (2H,t,J=7Hz), 2.58 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.41-3.68 (2H,m), 3.69 (1H,d,J=12Hz), 3.90 (2H,dd,J=6Hz,6Hz), 4.08 (1H,s), 4.57 (2H,d,J=6Hz), 5.28-5.41 (2H,m), 5.52-5.62 (1H,m), 5.65-5.83 (2H,m), 6.95 (1H,t,J=6Hz) Example 89 4-Oleoylaminobutenyl 3-[N-(2,2,5,5-tetramethyl -1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₄H₅₈N₂O₆ Molecular Weight 590.85 Mass Spectrometric Analysis: Calculated 590.4294 Found 590.4279 Specific Rotary Power: [α]²⁵ D +21.2°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2860, 1748, 1662 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.21-1.39 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.58-1.72 (2H,m), 1.92-2.08 (4H,m), 2.18 (2H,t,J=7Hz), 2.61 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.42-3.68 (2H,m), 3.70 (1H,d,J=12Hz), 4.08 (1H,s), 4.08-4.11 (2H,m), 4.69-4.72 (2H,m), 5.29-5.42 (2H,m), 5.68-5.78 (1H,m), 6.96 (1H,t,J=5Hz) Example 90 (R)-2-Oleoylamino-2-phenylethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₈H₆₂N₂O₆ Molecular Weight 642.92 Mass Spectrometric Analysis: Calculated 642.4607 Found 642.4613 Melting Point (°C): Oil Specific Rotary Power: [α]²⁴ D -0.4°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2864, 1744, 1654 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.04 (3H,s), 1.21-1.38 (20H,m), 1.44 (3H,s), 1.47 (3H,s), 1.57-1.70 (2H,m), 1.92-2.08 (4H,m), 2.25 (2H,t,J=7Hz), 2.52 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.46-3.65 (2H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 4.29-4.39 (2H,m), 5.29-5.42 (3H,m), 6.60 (1H,d,J=8Hz), 6.93 (1H,t,J=5Hz), 7.26-7.38 (5H,m) Example 91 (S)-2-Oleoylamino-2-phenylethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₈H₆₂N₂O₆ Molecular Weight 642.92 Mass Spectrometric Analysis: Calculated 642.4607 Found 642.4613 Melting Point (°C): Oil Specific Rotary Power: [α]²⁶ D +40.2°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2860, 1742, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.03 (3H,s), 1.21-1.39 (20H,m), 1.42 (3H,s), 1.46 (3H,s), 1.57-1.74 (2H,m), 1.91-2.08 (4H,m), 2.25 (2H,t,J=7Hz), 2.51 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.42-3.67 (2H,m), 3.68 (1H,d,J=12Hz), 4.05 (1H,s), 4.31 (1H,dd,J=12Hz,5Hz), 4.39 (1H,dd,J=12Hz,6Hz), 5.28-5.41 (3H,m), 6.59 (1H,d,J=8Hz) 6.91 (1H,t,J=5Hz), 7.25-7.38 (5H,m) Example 92 (Trans)-2-(oleoylamino)cyclopentane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₇H₆₆N₂O₆ Molecular Weight 634.94 Mass Spectrometric Analysis: Calculated 634.4920 Found 634.4911 Melting Point (°C): Oil Specific Rotary Power: [α]²⁶ D +22.0°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3328, 2932, 2864, 1734, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.00 (3H,s), 1.04 (3H,s), 1.21-1.38 (20H,m), 1.41-2.08 (16H,m), 1.43 (3H,s), 1.47 (3H,s), 2.09 (2H,t,J=7Hz), 2.50 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.32-3.44 (1H,m), 3.57-3.68 (1H,m), 3.69 (1H,d,J=12Hz), 3.99-4.09 (1H,m), 4.08 (1H,s), 4.77-4.84 (1H,m), 5.29-5.40 (2H,m), 5.82 (1H,d,J=8Hz), 6.97 (1H,t,J=6Hz) Example 93 (Trans)-2-(oleoylamino)cyclopentane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₇H₆₆N₂O₆ Molecular Weight 634.94 Mass Spectrometric Analysis: Calculated 634.4920 Found 634.4904 Melting Point (°C): Oil Specific Rotary Power: [α]²⁶ D +13.1°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3324, 2932, 2864, 1734, 1650 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.21-1.38 (20H,m), 1.40-2.08 (16H,m), 1.43 (3H,s), 1.47 (3H,s), 2.10 (2H,t,J=7Hz), 2.50 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.51 (2H,tt,J =6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.97-4.08 (1H,m), 4.09 (1H,s), 4.77-4.84 (1H,m), 5.29-5.42 (2H,m), 5.89 (1H,d,J=8Hz), 6.92 (1H,t,J=6Hz) Example 94 (S)-3-Methyl-2-oleoylaminobutyl 3-[N-(2,2,5,5 -tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₆₄N₂O₆ Molecular Weight 608.91 Mass Spectrometric Analysis: Calculated 608.4764 Found 608.4741 Melting Point (°C): Oil Specific Rotary Power: [α]²⁴ D +4.9°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3324, 2932, 2860, 1734, 1652 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.93 (3H,d,J=6Hz), 0.95 (3H,d,J=6Hz), 0.97 (3H,s), 1.03 (3H,s), 1.21-1.39 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.56-1.86 (3H,s), 1.90-2.08 (4H,m), 2.20 (2H,t,J=7Hz), 2.56 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.56 (2H,dt,J=6Hz,6Hz), 3.68 (1H,d,J= 12Hz), 3.95-4.29 (3H,m), 4.07 (1H,s), 5.29-5.41 (2H,m), 5.79 (1H,d,J=8Hz), 6.93 (1H,t,J=6Hz) Example 95 (S)-2-Oleoylaminobutyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₄H₆₂N₂O₆ Molecular Weight 594.88 Mass Spectrometric Analysis: Calculated 594.4607 Found 594.4597 Melting Point (°C): Oil Specific Rotary Power: [α]²⁵ D +6.2°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2864, 1742, 1652 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (3H,d,J=7Hz), 0.97 (3H,s), 1.03 (3H,s), 1.21-1.38 (20H,m), 1.42 (3H,s), 1.44-1.68 (4H,m), 1.47 (3H,s), 1.91-2.08 (4H,m), 2.17 (2H,t,J=7Hz), 2.58 (2H,t,J=6Hz), 3.29 (1H,d,J=12Hz), 3.57 (2H,dt,J =6Hz,6Hz), 3.68 (1H,d,J=12Hz), 4.03-4.24 (3H,m), 4.07 (1H,s), 5.29-5.42 (2H,m), 5.84 (1H,d,J=8Hz), 6.92 (1H,t,J=6Hz) Example 96 2-Oleoylamino-1-phenylethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₈H₆₂N₂O₆ Molecular Weight 642.92 Mass Spectrometric Analysis: Calculated 642.4607 Found 642.4606 Melting Point (°C): Oil Specific Rotary Power: [α]²⁴ D +24.3°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3324, 2932, 2864, 1744, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (3/2H,s), 0.99 (3/2H,s), 1.03 (3/2H,s), 1.04 (3/2H,s), 1.19-1.38 (20H,m), 1.41 (3/2H,s), 1.42 (3/2H,s), 1.43 (3H,s), 1.52-1.66 (2H,m), 1.92-2.08 (4H,m), 2.12-2.22 (2H,m), 2.48-2.67 (2H,m), 3.26 (1/2H,d,J=12Hz), 3.29 (1/2H,d,J=12Hz), 3.42-3.85 (4H,m), 3.68 (1H,d,J=12Hz), 4.06 (1/2H,s), 4.07 (1/2H,s), 5.29-5.41 (2H,m), 5.84 (1/2H,d,J=8Hz), 5.86 (1/2H,d,J=8Hz), 6.16-6.27 (1H,m), 6.88-6.97 (1H,m), 7.27-7.38 (5H,m) Example 97 (S)-2-Oleoylamino-3-phenylpropyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₉H₆₄N₂O₆ Molecular Weight 656.95 Mass Spectrometric Analysis: Calculated 656.4764 Found 656.4740 Melting Point (°C): Oil Specific Rotary Power: [α]²⁵ D +18.3°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3316, 2932, 2860, 1742, 1660 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.03 (3H,s), 1.17-1.38 (20H,m), 1.41 (3H,s), 1.46 (3H,s), 1.50-1.68 (2H,m), 1.92-2.08 (4H,m), 2.16 (2H,t,J=7Hz), 2.59 (2H,t,J=6Hz), 2.78 (1H,dd,J= 13Hz,7Hz), 2.89 (1H,dd,J=13Hz,6Hz), 3.28 (1H,d,J=12Hz), 3.39-3.69 (2H,m), 3.69 (1H,d,J= 12Hz), 4.04-4.09 (2H,m), 4.08 (1H,s), 4.37-4.44 (1H,m), 5.28-5.41 (2H,m), 6.07 (1H,d,J=8Hz), 6.93 (1H,t,J=5Hz), 7.16-7.32 (5H,m) Example 98 (S)-4-Methyl-2-oleoylaminopentyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₆H₆₆N₂O₆ Molecular Weight 622.93 Mass Spectrometric Analysis: Calculated 622.4920 Found 622.4895 Melting Point (°C): Oil Specific Rotary Power: [α]²⁵ D +7.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2864, 1742, 1652 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (3H,t,J=6Hz), 0.93 (3H,t,J=6Hz), 0.97 (3H,s), 1.03 (3H,s), 1.19-1.41 (20H,m), 1.42 (3H,s), 1.47 (3H,s), 1.53-1.77 (5H,m), 1.90-2.08 (4H,m), 2.17 (2H,t,J=7Hz), 2.57 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.56 (2H,dt,J=6Hz,6Hz), 3.68 (1H,d,J= 12Hz), 4.07 (1H,s), 4.07 (1H,dd,J=11Hz,4Hz), 4.13 (1H,dd,J=11Hz,4Hz), 4.21-4.35 (1H,m), 5.28-5.41 (2H,m), 5.72 (1H,d,J=8Hz), 6.94 (1H,t,J=6Hz) Example 99 2-(1-Oleoylaminocyclohexyl)ethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₇H₆₆N₂O₆ Molecular Weight 634.94 Mass Spectrometric Analysis: Calculated 634.4920 Found 634.4899 Melting Point (°C): Oil Specific Rotary Power: [α]²⁹ D +22.0°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3352, 2936, 2864, 1742, 1664 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.21-1.67 (32H,m), 1.42 (3H,s), 1.46 (3H,s), 1.91-2.13 (3H,m), 2.15 (2H,t,J=7Hz), 2.56 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.46-3.63 (2H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 4.31 (1H,d,J=11Hz), 4.36 (1H,d,J=11Hz), 5.13 (1H,s), 5.28-5.42 (2H,m), 6.96 (1H,t,J=5Hz) Example 100 (S)-2-Oleoylamino-2-phenylethyl N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)aminopropionate Molecular Formula C₃₇H₆₀N₂O₆ Molecular Weight 628.90 Mass Spectrometric Analysis: Calculated 628.4451 Found 628.4440 Melting Point (°C): Oil Specific Rotary Power: [α]²⁹ D +46.9°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2864, 1760, 1662 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.04 (6H,s), 1.19-1.38 (20H,m), 1.43 (3H,s), 1.48 (3H,s), 1.51-1.69 (2H,m), 1.91-2.05 (4H,m), 2.24 (2H,t,J=7Hz), 3.30 (1H,d,J=12Hz), 3.69 (1H,d,J=12Hz), 3.98 (2H,d,J=5Hz), 4.09 (1H,s), 4.39 (1H,dd,J= 11Hz,6Hz), 4.56 (1H,dd,J=11Hz,5Hz), 5.28-5.40 (3H,m), 6.25 (1H,d,J=8Hz), 7.00 (1H,t,J=5Hz), 7.26-7.39 (5H,m) Example 101 (S)-2-Oleoylamino-2-phenylethyl 4-[N-(2,2,5,5 -tetramethyl-1,3-dioxane-4-carbonyl)animo]butanoate Molecular Formula C₃₉H₆₄N₂O₆ Molecular Weight 656.95 Mass Spectrometric Analysis: Calculated 656.4764 Found 656.4770 Melting Point (°C): Oil Specific Rotary Power: [α]³⁰ D +41.4°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2864, 1744, 1654 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (6H,s), 1.06 (3H,s), 1.21-1.38 (20H,m), 1.44 (3H,s), 1.48 (3H,s), 1.56-2.07 (8H,m), 2.26 (2H,t,J=7Hz), 2.32 (2H,d,J=6Hz), 3.16-3.38 (2H,m), 3.30 (1H,d,J= 12Hz), 3.70 (1H,d,J=12Hz), 4.09 (1H,s), 4.38 (1H,dd,J=11Hz,6Hz), 4.44 (1H,dd,J=11Hz,5Hz), 5.28-5.42 (3H,m), 6.64 (1H,d,J=5Hz), 6.76 (1H,t,J=8Hz), 7.26-7.38 (5H,m) Example 102 (S)-2-Oleoylamino-2-phenylethyl 5-[N-(2,2,5,5 -tetramethyl-1,3-dioxane-4-carbonyl)amino]pentanoate Molecular Formula C₄₀H₆₆N₂O₆ Molecular Weight 670.98 Mass Spectrometric Analysis: Calculated 670.4920 Found 670.4912 Melting Point (°C): Oil Specific Rotary Power: [α]³⁰ D +40.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3324, 2932, 2864, 1742, 1654 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (3H,s), 1.05 (3H,s), 1.20-1.38 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.47-1.70 (6H,m), 1.92-2.08 (4H,m), 2.22 (2H,t,J=7Hz), 2.33 (2H,d,J=6Hz), 3.12-3.30 (2H,m), 3.29 (1H,d,J=12Hz), 3.69 (1H,d,J= 12Hz), 4.08 (1H,s), 4.28 (1H,dd,J=11Hz,5Hz), 4.43 (1H,dd,J=11Hz,6Hz), 5.28-5.40 (3H,m), 6.19 (1H,d,J=8Hz), 6.68 (1H,t,J=5Hz), 7.26-7.39 (5H,m) Example 103 (1S,2S)-2-(2,2,-Dimethylstearoryl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₈H₇₀N₂O₆ Molecular Weight 650.99 Mass Spectrometric Analysis: Calculated 650.5233 Found 650.5244 Melting Point (°C): Oil Specific Rotary Power: [α]²⁸ D +10.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3380, 2932, 2860, 1734 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.09 (6H,s), 1.10-2.16 (38H,m), 1.43 (3H,s), 1.47 (3H,s), 2.42-2.62 (2H,m), 3.28 (1H,d,J= 12Hz), 3.39-3.63 (2H,m), 3.69 (1H,d,J=12Hz), 3.81-3.93 (1H,m), 4.08 (1H,s), 4.73 (1H,ddd,J= 11Hz,11Hz,4Hz), 5.80 (1H,d,J=8Hz), 6.92 (1H,t,J=5Hz) Example 104 (1S,2S)-2-(2,2,-Dimethyloleoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₈H₆₈N₂O₆ Molecular Weight 648.97 Mass Spectrometric Analysis: Calculated 648.5077 Found 648.5063 Melting Point (°C): Oil Specific Rotary Power: [α]²⁸ D +10.9°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3380, 2936, 2864, 1734, 1672 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.00-2.18 (34H,m), 1.03 (3H,s), 1.08 (6H,s), 1.42 (3H,s), 1.47 (3H,s), 2.41-2.62 (2H,m), 3.28 (1H,d,J= 12Hz), 3.38-3.62 (2H,m), 3.69 (1H,d,J=12Hz), 3.80-3.92 (1H,m), 4.07 (1H,s), 4.73 (1H,ddd,J= 11Hz,11Hz,4Hz), 5.28-5.41 (2H,m), 5.79 (1H,d,J= 8Hz), 6.92 (1H,t,J=5Hz) Example 105 (1S,2S)-2-(2-Methyloleoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₇H₆₆N₂O₆ Molecular Weight 634.94 Mass Spectrometric Analysis: Calculated 634.4920 Found 634.4950 Melting Point (°C): Oil Specific Rotary Power: [α]²⁸ D +10.8°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3324, 2936, 2864, 1734 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.06 (3/2H,d,J=7Hz), 1.08 (3/2H,d,J=7Hz), 1.09-2.18 (35H,m), 1.43 (3H,s), 1.47 (3H,s), 2.50 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.81-3.94 (1H,m), 4.08 (1H,s), 4.61-4.73 (1H,m), 5.28-5.42 (2H,m), 5.70-5.78 (1H,m), 6.91 (1H,t,J=6Hz) Example 106 (1S,2S)-2-(2-Methylpalmitoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₆₄N₂O₆ Molecular Weight 608.91 Mass Spectrometric Analysis: Calculated 608.4764 Found 608.4754 Melting Point (°C): 77 - 79°C (benzene/hexane) Specific Rotary Power: [α]²⁸ D +14.4°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3312, 2932, 2860, 1742, 1652 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.39 (3H,d,J=7Hz), 1.10-2.18 (35H,m), 1.43 (3H,s), 1.47 (3H,s), 2.43-2.58 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.38-3.93 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz,11Hz,4Hz), 5.76 (1H,d,J= 8Hz), 6.91 (1H,t,J=6Hz) Example 107 (1S,2S)-2-(2-Methylpalmitoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₆₄N₂O₆ Molecular Weight 608.91 Mass Spectrometric Analysis: Calculated 608.4764 Found 608.4762 Melting Point (°C): 92 - 94°C (benzene/hexane) Specific Rotary Power: [α]¹⁹ D +6.7°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3284, 2928, 2860, 1736, 1652 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.06 (3H,d,J=7Hz), 1.10-2.17 (35H,m), 1.43 (3H,s), 1.47 (3H,s), 2.50 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.82-3.95 (1H,m), 4.08 (1H,s), 4.67 (1H,ddd,J=11Hz,11Hz,4Hz), 5.73 (1H,d,J= 8Hz), 6.92 (1H,t,J=6Hz) Example 108 (1S,2S)-2-(2-Ethylmyristoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₄H₆₂N₂O₆ Molecular Weight 594.88 Mass Spectrometric Analysis: Calculated 594.4607 Found 594.4621 Melting Point (°C): Oil Specific Rotary Power: [α]¹⁹ D +10.1°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2936, 2864, 1734, 1648 NMR(δ, CDCl₃): 0.85 (3H,t,J=7Hz), 0.88 (3H,d,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.10-2.23 (33H,m), 1.43 (3H,s), 1.47 (3H,s), 2.42-2.59 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.38-3.95 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz,11Hz,4Hz), 5.85 (1H,d,J= 8Hz), 6.92 (1H,t,J=6Hz) Example 109 (1S,2S)-2-(2-Ethylmyristoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₄H₆₂N₂O₆ Molecular Weight 594.88 Mass Spectrometric Analysis: Calculated 594.4607 Found 594.4591 Melting Point (°C): Calomel Specific Rotary Power: [α]²⁰ D +9.6°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3288, 2928, 2860, 1736, 1680, 1648 NMR(δ, CDCl₃): 0.82 (3H,t,J=7Hz), 0.88 (3H,d,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.09-2.18 (33H,m), 1.43 (3H,s), 1.47 (3H,s), 2.41-2.58 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (2H,dd,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.85-3.98 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz,11Hz,4Hz), 5.79 (1H,d,J= 8Hz), 6.92 (1H,t,J=6Hz) Example 110 (1S,2S)-2-(2-Propylstearoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₉H₇₂N₂O₆ Molecular Weight 665.01 Mass Spectrometric Analysis: Calculated 664.5390 Found 664.5395 Melting Point (°C): Calomel Specific Rotary Power: [α]¹⁹ D +9.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3288, 2932, 2860, 1730, 1670, 1644 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.88 (3H,d,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.12-2.23 (43H,m), 1.43 (3H,s), 1.47 (3H,s), 2.42-2.58 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.83-3.95 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz,11Hz,4Hz), 5.82 (1H,d,J= 8Hz), 6.92 (1H,t,J=6Hz) Example 111 (1S,2S)-2-(2-Propylstearoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₉H₇₂N₂O₆ Molecular Weight 665.01 Mass Spectrometric Analysis: Calculated 664.5390 Found 664.5390 Melting Point (°C): 103 - 105°C (benzene/hexane) Specific Rotary Power: [α]²⁰ D +8.0°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3288, 2928, 2860, 1730, 1666, 1644 NMR(δ, CDCl₃): 0.86 (3H,t,J=7Hz), 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.11-2.21 (43H,m), 1.43 (3H,s), 1.47 (3H,s), 2.41 2.60 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.83-3.97 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz,11Hz,4Hz), 5.77 (1H,d,J= 8Hz), 6.92 (1H,t,J=6Hz) Example 112 (1S,2S)-2-(1-Laurylcyclopentanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane -4-carbonyl)amino]propionate Molecular Formula C₃₆H₆₄N₂O₆ Molecular Weight 620.92 Mass Spectrometric Analysis: Calculated 620.4764 Found 620.4775 Melting Point (°C): Oil Specific Rotary Power: [α]²² D +9.2°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3360, 2932, 2864, 1732 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.11-2.18 (38H,m), 1.43 (3H,s), 1.47 (3H,s), 2.42-2.62 (2H,m), 3.28 (1H,d,J=12Hz), 3.38-3.42 (2H,m), 3.69 (1H,d,J=12Hz), 3.80-3.92 (1H,m), 4.08 (1H,s), 4.73 (1H,ddd,J= 11Hz,11Hz,4Hz), 5.76 (1H,d,J=8Hz), 6.92 (1H,t,J=6Hz) Example 113 (1S,2S)-2-(1-Decylcyclobutanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane -4-carbonyl)amino]propionate Molecular Formula C₃₃H₅₈N₂O₆ Molecular Weight 578.84 Mass Spectrometric Analysis: Calculated 578.4294 Found 578.4285 Melting Point (°C): Oil Specific Rotary Power: [α]²² D +8.9°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3336, 2936, 2864, 1734 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.06-1.40 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.57-2.34 (12H,m), 2.43-2.62 (2H,m), 3.28 (1H,d,J=12Hz), 3.41-3.62 (2H,m), 3.69 (1H,d,J= 12Hz), 3.81-3.94 (1H,m), 4.07 (1H,s), 4.71 (1H,ddd,J=11Hz,11Hz,5Hz), 5.59 (1H,d,J=8Hz), 7.92 (1H,t,J=5Hz) Example 114 (1S,2S)-2-(1-Oleylcyclopentanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane -4-carbonyl)amino]propionate Molecular Formula C₄₂H₇₄N₂O₆ Molecular Weight 701.05 Mass Spectrometric Analysis: Calculated 702.5546 Found 702.5570 Melting Point (°C): Oil Specific Rotary Power: [α]²² D +8.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3368, 2932, 2864, 1734 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.09-2.17 (46H,m), 1.43 (3H,s), 1.47 (3H,s), 2.41-2.61 (2H,m), 3.28 (1H,d,J=12Hz), 3.37-3.62 (2H,m), 3.69 (1H,d,J=12Hz), 3.81-3.93 (1H,m), 4.08 (1H,s), 4.73 (1H,ddd,J=11Hz,11Hz,4Hz), 5.28-5.40 (2H,m), 5.75 (1H,d,J=8Hz), 6.93 (1H,t,J=5Hz) Example 115 (1S,2S)-2-[(1-Methyl-8-heptadecenyl)carbamoyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₇H₆₇N₃O₆ Molecular Weight 649.96 Mass Spectrometric Analysis: Calculated 649.5029 Found 649.5029 Melting Point (°C): Oil Specific Rotary Power: [α]²¹ D +19.3°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3360, 2936, 2864, 1734, 1682, 1644 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.08 (3/2H,d,J=6Hz), 1.09 (3/2H,d,J=6Hz), 1.14-1.50 (24H,m), 1.44 (3H,s), 1.47 (3H,s), 1.52-2.26 (11H,m), 2.37-2.59 (2H,m), 3.28-3.46 (1H,m), 3.58-3.80 (3H,m), 3.69 (1H,d,J=12Hz), 4.10 (1H,s), 4.55 (1H,ddd,J=11Hz,11Hz,4Hz), 5.28-5.42 (2H,m), 6.86-6.96 (1H,m) 6xample 116 (1S,2S)-2-[(1-Methylpentadecanyl)carbamoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₆₅N₃O₆ Molecular Weight 623.92 Mass Spectrometric Analysis: Calculated 623.4873 Found 623.4852 Melting Point (°C): Oil Specific Rotary Power: [α]²¹ D +20.5°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹) 3360, 2932, 2860, 1738, 1682, 1642 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.08 (3H,d,J=6Hz), 1.12-1.78 (32H,m), 1.44 (3H,s), 1.47 (3H,s), 1.94-2.58 (4H,m), 3.28 (1H,d,J=12Hz), 3.34-3.79 (4H,m), 3.69 (1H,d,J= 12Hz), 4.10 (1H,s), 4.55 (1H,ddd,J=11Hz,11Hz, 4Hz), 6.92 (1H,t,J=5Hz) Example 117 (1S,2S)-2-(1-Octylcyclobutanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₁H₅₄N₂O₆ Molecular Weight 550.78 Mass Spectrometric Analysis: Calculated 550.3981 Found 550.4005 Melting Point (°C): Oil Specific Rotary Power: [α]³⁰ D +13.1°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3336, 2932, 2860, 1732 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.06-1.58 (16H,m), 1.43 (3H,s), 1.47 (3H,s), 1.60-2.36 (12H,m), 3.43-2.63 (2H,m), 3.28 (1H,d,J=12Hz), 3.39-3.63 (2H,m), 3.69 (1H,d,J= 12Hz), 3.81-3.94 (1H,m), 4.08 (1H,s), 4.72 (1H,ddd,J=11Hz,11Hz,4Hz), 5.60 (1H,d,J=8Hz), 6.93 (1H,t,J=5Hz) Example 118 (1S,2S)-2-(1-Isopropyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)-amino]propionate Molecular Formula C₃₃H₆₀N₂O₆ Molecular Weight 580.85 Mass Spectrometric Analysis: Calculated 580.4451 Found 580.4435 Melting Point (°C): wax Specific Rotary Power: [α]²⁷ D +11.9°(C=0.9, CHCl₃) IR(νKBr, cm⁻¹): 3288, 2932, 2860, 1730 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.88 (3H,d,J=6Hz), 0.91 (3H,d,J=6Hz), 0.96 (3H,s), 1.04 (3H,s), 1.00-1.82 (26H,m), 1.43 (3H,s), 1.47 (3H,s), 1.93-2.04 (1H,m), 2.15-2.26 (1H,m), 2.41-2.58 (2H,m), 3.28 (1H,d,J=12Hz), 3.42-3.60 (2H,m), 3.69 (1H,d,J=12Hz), 3.82-3.94 (1H,m), 4.08 (1H,s), 4.67 (1H,ddd,J=11Hz,11Hz,4Hz), 5.87 (1H,d,J=8Hz), 6.91 (1H,t,J=5Hz) Example 119 (1S,2S)-2-(1-Isopropyllauroyl)aminocyclohexane -1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₆₀H₂O₆ Molecular Weight 580.85 Mass Spectrometric Analysis: Calculated 580.4451 Found 580.4458 Melting Point (°C): Calomel Specific Rotary Power: [α]³⁰ D +10.6°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3276, 2932, 2860, 1730 NMR(δ, CDCl₃): 0.85 (3H,d,J=6Hz), 0.88 (3H,t,J=7Hz), 0.89 (3H,d,J=6Hz), 0.96 (3H,s), 1.04 (3H,s), 1.05-1.83 (26H,m), 1.43 (3H,s), 1.47 (3H,s), 1.92-2.04 (1H,m), 2.13-2.22 (1H,m), 2.40-2.58 (2H,m), 3.28 (1H,d,J=12Hz), 3.45-3.58 (2H,m), 3.69 (1H,d,J=12Hz), 3.85-3.97 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz,11Hz,4Hz), 5.78 (1H,d,J=8Hz), 6.90 (1H,t,J=5Hz) Example 120 (1S,2S)-2-(1-Hexylcyclobutanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane -4-carbonyl)amino]propionate Molecular Formula C₂₉H₅₀N₂O₆ Molecular Weight 522.73 Mass Spectrometric Analysis: Calculated 522.3668 Found 522.3668 Melting Point (°C): oil Specific Rotary Power: [α]³⁰ D +13.8°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3336, 2936, 2864, 1732 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.07-1.58 (12H,m), 1.42 (3H,s), 1.47 (3H,s), 1.61-2.34 (12H,m), 2.43-2.62 (2H,m), 3.28 (1H,d,J=12Hz), 3.41-3.62 (2H,m), 3.69 (1H,d,J= 12Hz), 3.82-3.93 (1H,m), 4.07 (1H,s), 4.71 (1H,ddd,J=11Hz,11Hz,4Hz), 5.60 (1H,d,J=8Hz), 6.92 (1H,t,J=5Hz) Example 121 (1S,2S)-2-(1-Butylcyclobutanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane -4-carbonyl)amino]propionate Molecular Formula C₂₇H₄₆N₂O₆ Molecular Weight 494.67 Mass Spectrometric Analysis: Calculated 494.3355 Found 494.3366 Melting Point (°C): Calomel Specific Rotary Power: [α]³⁰ D +15.2°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3348, 2940, 2868, 1732 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.05-1.58 (8H,m), 1.43 (3H,s), 1.47 (3H,s), 1.62-2.33 (12H,m), 2.44-2.61 (2H,m), 3.28 (1H,d,J=12Hz), 3.41-3.63 (2H,m), 3.69 (1H,d,J= 12Hz), 3.81-3.94 (1H,m), 4.08 (1H,s), 4.72 (1H,ddd,J=11Hz,11Hz,4Hz), 5.61 (1H,d,J=8Hz), 6.93 (1H,t,J=5Hz) Example 122 (1S,2S)-2-(1-Decylcyclobutanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,4-dihydroxy-3,3-diemthyl-1-oxobutyl)amino]propionate Molecular Formula C₃₀H₅₄N₂O₆ Molecular Weight 538.77 Mass Spectrometric Analysis: Calculated 538.3981 Found 538.3989 Melting Point (°C): oil Specific Rotary Power: [α]²⁸ D +10.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1732 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.05 (3H,s), 1.06-1.44 (20H,m), 1.46-2.28 (12H,m), 2.44-2.64 (2H,m), 2.77 (2H,brs), 3.46-3.68 (2H,m), 3.49 (1H,d,J=11Hz), 3.56 (1H,d,J=11Hz), 3.84-3.98 (1H,m), 4.05 (1H,s), 4.69 (1H,ddd,J=11Hz, 11Hz,4Hz), 5.53 (1H,d,J=9Hz), 7.37 (1H,t,J=5Hz) Example 123 (1S,2S)-2-(1-Methyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₁H₅₆N₂O₆ Molecular Weight 552.80 Mass Spectrometric Analysis: Calculated 552.4138 Found 552.4127 Melting Point (°C): oil Specific Rotary Power: [α]³¹ D +15.8°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3304, 2932, 2860, 1738 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.95 (3H,s), 1.03 (3H,s), 1.07 (3H,t,J=7Hz), 1.10-1.38 (20H,m), 1.42 (3H,s), 1.46 (3H,s), 1.48-2.19 (7H,m), 2.42-2.57 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (1H,dt,J= 6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.81-3.94 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=4Hz), 5.76 (1H,d,J= 8Hz), 6.92 (1H,t,J=6Hz) Example 124 (1S,2S)-2-(1-Methyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₁H₅₆N₂O₆ Molecular Weight 552.80 Mass Spectrometric Analysis: Calculated 552.4138 Found 552.4139 Melting Point (°C): wax Specific Rotary Power: [α]³⁰ D +7.6°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3272, 2932, 2860, 1744 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.06 (3H,d,J=7Hz), 1.10-1.39 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.49-2.16 (7H,m), 2.50 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.51 (1H,dt,J =6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.82-3.96 (1H,m), 4.08 (1H,s), 4.67 (1H,ddd,J=11Hz,11Hz,4Hz), 5.73 (1H,d,J=8Hz), 6.92 (1H,t,J=6Hz) Example 125 (1S,2S)-2-(2-Decyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₄₀H₇₄N₂O₆ Molecular Weight 679.04 Mass Spectrometric Analysis: Calculated 678.5546 Found 678.5535 Melting Point (°C): 70 - 71°C (hexane) Specific Rotary Power: [α]²⁸ D +10.3°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3288, 2928, 2856, 1732 NMR(δ, CDCl₃): 0.88 (6H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.08-2.22 (45H,m), 1.43 (3H,s), 1.47 (3H,s), 2.39-2.58 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.83-3.96 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz, 11Hz,4Hz), 5.82 (1H,d,J=8Hz), 6.90 (1H,t,J=8Hz) Example 126 (1S,2S)-2-(N-Decyl-N-isopropylcarbamoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane -4-carbonyl)amino]propionate Molecular Formula C₃₂H₅₉N₃O₆ Molecular Weight 581.84 Mass Spectrometric Analysis: Calculated 581.4403 Found 581.4414 Melting Point (°C): oil Specific Rotary Power: [α]²⁷ D +30.1°(C=0.5, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1732 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.10 (6H,d,J=7Hz), 1.15-2.21 (24H,m), 1.42 (3H,s), 1.47 (3H,s), 2.47-2.62 (2H,m), 2.93 (2H,t,J=7Hz), 3.28 (1H,d,J=12Hz), 3.34-3.64 (2H,m), 3.69 (1H,d,J=12Hz), 3.74-3.88 (1H,m), 4.08 (1H,s), 4.18-4.33 (1H,m), 4.38-4.46 (1H,m), 4.71 (1H,ddd,J=11Hz,11Hz,4Hz), 6.93 (1H,t,J=5Hz) Example 127 (1S,2S)-2-[N-(2,2-Dimethylpropyl)-N-nonylcarbamoyl)]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₆₁N₃O₆ Molecular Weight 595.87 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (9H,s), 0.96 (3H,s), 1.04 (3H,s), 1.05-2.21 (22H,m), 1.42 (3H,s), 1.47 (3H,s), 2.43-2.62 (2H,m), 2.91 (1H,d,J= 15Hz), 2.97-3.10 (1H,m), 3.05 (1H,d,J=15Hz), 3.16-3.27 (1H,m), 3.28 (1H,d,J=12Hz), 3.37-3.64 (2H,m), 3.69 (1H,d,J=12Hz), 3.71-3.86 (1H,m), 4.08 (1H,s), 4.52 (1H,d,J=8Hz), 4.70 (1H,ddd,J= 11Hz,11Hz,4Hz), 6.92 (1H,t,J=5Hz) Example 128 (1S,2S)-2-(2-Phenylmethycapryloyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₅₂N₂O₆ Molecular Weight 572.79 Mass Spectrometric Analysis: Calculated 572.3825 Found 572.3841 Melting Point (°C): Calomel Specific Rotary Power: [α]²¹ D -5.8°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3304, 2936, 2864, 1734, 1662, 1646 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.95 (3H,s), 1.03 (3H,s), 1.05-1.95 (18H,m), 1.42 (3H,s), 1.46 (3H,s), 2.89-2.24 (1H,m), 2.37-2.54 (2H,m), 2.68 (1H,dd,J=13Hz,5Hz), 2.83 (1H,dd,J=13Hz,10Hz), 3.28 (1H,d,J=12Hz), 3.48 (2H,dt,J=6Hz,6Hz), 3.68 (1H,d,J=12Hz), 3.70-3.82 (1H,m), 4.07 (1H,s), 4.50 (1H,ddd,J=11Hz,11Hz,4Hz), 5.42 (1H,d,J=8Hz), 6.88 (1H,t,J=6Hz) Example 129 (1S,2S)-2-(2-Phenylmethycapryloyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₃H₅₂N₂O₆ Molecular Weight 572.79 Mass Spectrometric Analysis: Calculated 572.3825 Found 572.3812 Melting Point (°C): Calomel Specific Rotary Power: [α]²¹ D +26.1°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3320, 2940, 2864, 1734, 1652 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.95 (3H,s), 1.03 (3H,s), 1.05-1.47 (12H,m), 1.43 (3H,s), 1.47 (3H,s), 1.51-2.31 (9H,m), 2.61 (1H,dd,J=14Hz,5Hz), 2.94 (1H,dd,J=14Hz,9Hz), 3.22-3.28 (2H,m), 3.28 (1H,d,J=12Hz), 3.69 (1H,d,J=12Hz), 3.70-3.84 (1H,m), 4.07 (1H,s), 4.55 (1H,ddd,J=11Hz,11Hz, 4Hz), 5.93 (1H,d,J=8Hz), 6.81 (1H,t,J=5Hz), 7.12-7.30 (5H,m) Example 130 (1S,2S)-2-(2-Phenyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₆H₅₈N₂O₆ Molecular Weight 614.87 Mass Spectrometric Analysis: Calculated 614.4294 Found 614.4310 Melting Point (°C): oil Specific Rotary Power: [α]³⁰ D +14.8°(C=0.9, CHCl₃) IR(νneat, cm⁻¹): 3312, 2932, 2860, 1734 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.97 (3H,s), 1.05 (3H,s), 1.11-1.39 (20H,m), 1.43 (3H,s), 1.48 (3H,s), 1.52-2.11 (6H,m), 2.32-2.51 (2H,m), 3.25 (1H,t,J=7Hz), 3.29 (1H,d,J=12Hz), 3.38-3.56 (2H,m), 3.70 (1H,d,J=12Hz), 3.77-3.89 (1H,m), 4.09 (1H,s), 4.59 (1H,ddd,J=11Hz,11Hz,4Hz), 5.68 (1H,d,J=8Hz), 6.89 (1H,t,J=5Hz), 7.21-7.36 (5H,m) Example 131 (1S,2S)-2-(2-Phenyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₆H₅₈N₂O₆ Molecular Weight 614.87 Mass Spectrometric Analysis: Calculated 614.4294 Found 614.4311 Melting Point (°C): wax Specific Rotary Power: [α]³⁰ D +34.4°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3308, 2932, 2860, 1730 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.94 (3H,s), 1.35 (3H,s), 1.09-1.42 (20H,m), 1.43 (3H,s), 1.48 (3H,s), 1.52-2.15 (8H,m), 3.20-3.21 (3H,m), 3.28 (1H,d,J=12Hz), 3.68 (1H,d,J=12Hz), 3.76-3.89 (1H,m), 4.06 (1H,s), 4.59 (1H,ddd,J=11Hz,11Hz,4Hz), 5.75 (1H,d,J=8Hz), 6.71 (1H,t,J=5Hz), 7.19-7.34 (5H,m) Example 132 (1S,2S)-2-(1-Benzylcyclopentanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₀H₄₄N₂O₆ Molecular Weight 528.69 Mass Spectrometric Analysis: Calculated 528.3199 Found 528.3193 Melting Point (°C): Calomel Specific Rotary Power: [α]³⁰ D +11.9°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3356, 2944, 2868, 1732 NMR(δ, CDCl₃): 0.84-1.55 (4H,m), 0.95 (3H,s), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 1.58-2.67 (12H,m), 3.00 (1H,d,J=14Hz), 3.03 (1H,d,J=14Hz), 3.28 (1H,d,J=12Hz), 3.27-3.52 (2H,m), 3.68 (1H,d,J= 12Hz), 3.72-3.82 (1H,m), 4.06 (1H,s), 4.59 (1H,ddd,J=11Hz,11Hz,4Hz), 5.41 (1H,d,J=8Hz), 6.88 (1H,t,J=5Hz), 7.11-7.28 (5H,m) Example 133 (1S,2S)-2-(1-Furfurylcyclobutanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₂₈H₄₂N₂O₇ Molecular Weight 518.65 Mass Spectrometric Analysis: Calculated 518.2992 Found 518.2969 Melting Point (°C): oil Specific Rotary Power: [α]³⁰ D +12.8°(C=0.5, CHCl₃) IR(νKBr, cm⁻¹): 3352, 2944, 2868, 1732 NMR (δ, CDCl₃): 0.96 (3H,s), 1.03 (3H,s), 1.18-2.57 (16H,m), 1.42 (3H,s), 1.47 (3H,s), 3.03 (2H,s), 3.28 (1H,d,J=12Hz), 3.33-3.58 (2H,m), 3.69 (1H,d,J= 12Hz), 3.67-3.90 (1H,m), 4.07 (1H,s), 4.63 (1H,ddd,J=11Hz,11Hz,4Hz), 5.49 (1H,d,J=8Hz), 6.03 (1H,d,J=3Hz), 6.26 (1H,dd,J=3Hz,1Hz), 6.92 (1H,t,J=5Hz), 7.29 (1H,d,J=1Hz) Example 134 (1S,2S)-2-(2-Benzyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₇H₆₀N₂O₆ Molecular Weight 628.90 Mass Spectrometric Analysis: Calculated 628.4451 Found 628.4442 Melting Point (°C): wax Specific Rotary Power: [α]²⁹ D -5.9°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2860, 1732 NMR(δ, CDCl₃): 0.62-1.50 (20H,m), 0.88 (3H,t,J=7Hz), 0.95 (3H,s), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 1.52-2.30 (7H,m), 2.38-2.55 (2H,m), 2.68 (1H,dd,J=15Hz,6Hz), 2.83 (1H,dd,J=15Hz,10Hz), 3.28 (1H,d,J=12Hz), 3.48 (2H,dt,J=6Hz,6Hz), 3.68 (1H,d,J=12Hz), 3.70-3.83 (1H,m), 4.07 (1H,s), 4.50 (1H,ddd,J=11Hz,11Hz,5Hz), 5.91 (1H,d,J=8Hz), 6.88 (1H,t,J=6Hz), 7.11-7.27 (5H,m) Example 135 (1S,2S)-2-(2-Benzyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₇H₆₀H₂O₆ Molecular Weight 628.90 Mass Spectrometric Analysis: Calculated 628.4451 Found 628.4478 Melting Point (°C): wax Specific Rotary Power : [α]²⁷ D +26.7°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3300, 2932, 2860, 1734 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.95 (3H,S), 1.03 (3H,s), 1.06-1.50 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.52-2.30 (9H,m), 2.61 (1H,dd,J=15Hz,6Hz), 2.93 (1H,dd,J=15Hz,10Hz), 3.20-3.30 (2H,m), 3.28 (1H,d,J=12Hz), 3.69 (1H,d,J=12Hz), 3.71-3.83 (1H,m), 4.07 (1H,s), 4.55 (1H,ddd,J= 11Hz,11Hz,4Hz), 5.91 (1H,d,J=7Hz), 6.81 (1H,t,J =5Hz), 7.31-7.28 (5H,m) Example 136 (1S,2S)-2-(1-Cinnamylcyclobutanecarbonyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₂H₄₆N₂O₆ Molecular Weight 554.73 Mass Spectrometric Analysis: Calculated 554.3355 Found 554.3361 Melting Point (°C): Calomel Specific Rotary Power : [α]⁹ D +14.9°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3340, 2944, 2868, 1732 NMR(δ, CDCl₃): 0.89-1.57 (4H,m), 0.95 (3H,s), 1.03 (3H,s), 1.41 (3H,s), 1.46 (3H,s), 1.58-2.67 (12H,m), 2.59 (2H,d,J=7Hz), 3.27 (1H,d,J=12Hz), 3.32-3.63 (2H,m), 3.68 (1H,d,J=12Hz), 3.82-3.95 (1H,m), 4.06 (1H,s), 4.68 (1H,ddd,J=11Hz,11Hz, 4Hz), 5.68 (1H,d,J=8Hz), 6.08 (1H,dt,J=16Hz, 7Hz), 6.44 (1H,d,J=16Hz), 6.88 (1H,t,J=5Hz), 7.17-7.38 (5H,m) Example 137 (1S,2S)-2-[1-(3-Phenylpropyl)cyclobutanecarbonyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₂H₄₈N₂O₆ Molecular Weight 556.74 Mass Spectrometric Analysis: Calculated 556.3512 Found 556.3516 Melting Point (°C): Calomel Specific Rotary Power : [α]⁹ D +12.5°(C=1.0, CHCl₃) IR(νKBr, cm⁻¹): 3352, 2940, 2868, 1732 NMR(δ, CDCl₃): 0.95 (3H,s), 0.95-1.56 (6H,m), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 1.62-2.48 (14H,m), 2.51-2.66 (2H,m), 3.27 (1H,d,J=12Hz),3.28-3.48 (2H,m), 3.68 (1H,d,J=12Hz), 3.79-3.92 (1H,m), 4.06 (1H,s), 4.67 (1H,ddd,J=11Hz,11Hz,4Hz), 5.64 (1H,d,J=8Hz), 6.86 (1H,t,J=5Hz), 7.12-7.30 (5H,m) Example 138 (1S,2S)-2-(2,2-Diphenyllauroyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₄₂H₆₂N₂O₆ Molecular Weight 690.97 Mass Spectrometric Analysis: Calculated 690,4607 Found 690,4604 Melting Point (°C): oil Specific Rotary Power : [α]⁹ D +18.8°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1730 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.94 (3H,s), 1.00-1.49 (20H,m), 1.04 (3H,s), 1.42 (3H,s), 1.47 (3H,s), 1.52-2.38 (8H,m), 3.16-3.28 (1H,m), 3.28 (1H,d,J=12Hz), 3.36-3.48 (1H,m), 3.69 (1H,d,J= 12Hz), 3.82-3.94 (1H,m), 4.07 (1H,s), 4.49 (1H,ddd,J=11Hz,11Hz,4Hz), 5.52 (1H,d,J=8Hz), 6.82 (1H,t,J=5Hz), 7.18-7.37 (10H,m) Example 139 (1S,2S)-2-(2,2-Benzylcapryloyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₀H₄₈N₂O₆ Molecular Weight 532.72 Mass Spectrometric Analysis: Calculated 532.3512 Found 532.3524 Melting Point (°C): Calomel Specific Rotary Power : [α]⁹ D +28.8°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2936, 2864, 1728 NMR(δ, CDCl₃): 0.86 (3H,t,J=7Hz), 0.94 (3H,s), 1.02 (3H,s), 1.06-1.50 (12H,m), 1.52-2.35 (9H,m), 2.64 (1H,dd,J=14Hz,6Hz), 2.89 (1H,dd,J=14Hz,8Hz), 3.22-3.48 (2H,m), 3.48 (1H,d,J=11Hz), 3.51 (1H,d,J=11Hz), 3.72-3.87 (1H,m), 4.03 (1H,s), 4.54 (1H,ddd,J=11Hz,11Hz,4Hz), 5.88 (1H,brs), 7.12-7.29 (6H,m) Example 140 (1S,2S)-2-(N-Benzyl-N-hexylcarbamoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₂H₅₁N₃O₆ Molecular Weight 573.78 Mass Spectrometric Analysis: Calculated 573.3777 Found 573.3752 Melting Point (°C): oil Specific Rotary Power : [α]⁸ D +33.2°(C=0.8, CHCl₃) IR(νneat, cm⁻¹): 3384, 2936, 2864, 1732 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.96 (3H,s), 0.97-2.18 (16H,m), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 2.32-2.53 (2H,m), 3.18 (2H,t,J=7Hz), 3.26-3.39 (1H,m), 3.28 (1H,d,J=12Hz), 3.43-3.56 (1H,m), 3.69 (1H,d,J=12Hz), 3.72-3.85 (1H,m), 4.07 (1H,s), 4.36 (1H,d,J=17Hz), 4.46 (1H,d,J=17Hz), 4.50 (1H,d,J=6Hz), 4.62 (1H,ddd,J=11Hz,11Hz, 4Hz), 6.88 (1H,t,J=5Hz), 7.19-7.37 (5H,m) Example 141 (1S,2S)-2-(N-Benzyl-N-octylcarbamoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₄H₅₅N₃O₆ Molecular Weight 601.83 Mass Spectrometric Analysis: Calculated 601.4090 Found 601.4113 Melting Point (°C): oil Specific Rotary Power : [α]⁸ D +29.7°(C=0.5, CHCl₃) IR(νneat, cm⁻¹): 3368, 2932, 2864, 1732 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.96 (3H,s), 0.97-2.18 (20H,m), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 2.33-2.53 (2H,m), 3.18 (2H,t,J=7Hz), 3.26-3.39 (1H,m), 3.28 (1H,m), 3.43-3.56 (1H,m), 3.69 (1H,d,J=12Hz), 3.72-3.85 (1H,m), 4.07 (1H,s), 4.37 (1H,d,J=17Hz), 4.48 (1H,d,J=17Hz), 4.49 (1H,d,J=6Hz), 4.62 (1H,ddd,J=11Hz,11Hz,4Hz), 6.88 (1H,t,J=5Hz), 7.19-7.36 (5H,m) Example 142 (1S,2S)-2-(N-Benzyl-N-decylcarbamoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₆H₅₉N₃O₆ Molecular Weight 629.88 Mass Spectrometric Analysis: Calculated 629.4403 Found 629.4388 Melting Point (°C): oil Specific Rotary Power : [α]⁷ D +26.1°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3384, 2932, 2860, 1732 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 0.79-2.19 (24H,m), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 2.32-2.53 (2H,m), 2.18 (2H,t,J=7Hz), 3.23-3.38 (1H,m), 3.28 (1H,d,J=12Hz), 3.32-3.55 (1H,m), 3.69 (1H,d,J=12Hz), 3.70-3.85 (1H,m), 4.07 (1H,s), 4.36 (1H,d,J=17Hz), 4.47 (1H,d,J=17Hz), 4.48 (1H,d,J=6Hz), 4.61 (1H,ddd,J=11Hz,11Hz,4Hz), 6.89 (1H,t,J=5Hz), 7.20-7.39 (5H,m) Example 143 (1S,2S)-2-(2-Benzylundecanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₆H₅₈N₂O₆ Molecular Weight 614.87 Mass Spectrometric Analysis: Calculated 614.4294 Found 614.4295 Melting Point (°C): wax Specific Rotary Power : [α]⁸ D -7.7°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3320, 2932, 2860, 1732 NMR(δ, CDCl₃): 0.62-1.49 (18H,m), 0.88 (3H,t,J=7Hz), 0.95 (3H,s), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 1.51-1.95 (6H,m), 2.08-2.19 (1H,m), 2.37-2.56 (2H,m), 2.68 (1H,dd,J=14Hz,6Hz), 2.83 (1H,dd,J= 14Hz,9Hz), 3.28 (1H,d,J=12Hz), 3.44-3.52 (2H,m), 3.68 (1H,d,J=12Hz), 3.70-3.82 (1H,m), 4.07 (1H,s), 4.51 (1H,ddd,J=11Hz,11Hz,4Hz), 5.42 (1H,d,J=8Hz), 6.88 (1H,t,J=5Hz), 7.11-7.30 (5H,m) Example 144 (1S,2S)-2-(2-Benzylundecanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₆H₅₈N₂O₇ Molecular Weight 614.87 Mass Spectrometric Analysis: Calculated 614.4294 Found 614.4276 Melting Point (°C): oil Specific Rotary Power : [α]⁷ D +27.4°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 3304, 2932, 2860, 1734 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.95 (3H,s), 0.98-1.49 (18H,m), 1.03 (3H,s), 1.43 (3H,s), 1.47 (3H,s), 1.52-2.30 (9H,m), 2.61 (1H,dd,J=14Hz,6Hz), 2.94 (1H,dd,J=14Hz,9Hz), 3.22-3.29 (2H,m), 3.28 (1H,d,J=12Hz), 3.69 (1H,d,J=12Hz), 3.71-3.84 (1H,m), 4.07 (1H,s), 4.55 (1H,ddd,J=11Hz,11Hz, 4Hz), 5.91 (1H,d,J=8Hz), 6.81 (1H,t,J=5Hz), 7.12-7.28 (5H,m) Example 145 (1S,2S)-2-(3-Hexyl-2-nonenoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₃H₅₈N₂O₆ Molecular Weight 578.93 IR(νneat ,cm⁻¹): 1660, 1736 NMR(δ, CDCl₃): 0.87 (3H,t,J=7Hz), 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.10-1.50 (16H,m), 1.43 (3H,s), 1.47 (3H,s), 1.57-1.88 (6H,m), 1.88-2.18 (4H,m), 2.43-2.64 (4H,m), 3.28 (1H,d,J= 12Hz), 3.49 (2H,t,J=6Hz), 3.69 (1H,d,J=12Hz), 3.84-4.02 (1H,m), 4.08 (1H,s), 4.64 (1H,ddd,J =11Hz,11Hz,4Hz), 5.42 (1H,s), 5.67 (1H,d,J= 8Hz), 6.92 (1H,m) Example 146 (1S,2S)-2-(3-Phenylmethyl-4-phenyl-2-butenoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₅H₄₆N₂O₆ Molecular Weight 590.83 Melting Point (°C): wax NMR(δ, CDCl₃): 0.95 (3H,s), 1.00 (3H,s), 0.90-2.12 (8H,m), 1.39 (3H,s), 1.45 (3H,s), 2.24-2.54 (2H,m), 3.07 (2H,dd,J=15Hz,3Hz), 3.26 (1H,d,J=12Hz), 3.20-3.64 (2H,m), 3.53 (2H,dd,J=15Hz,5Hz), 3.67 (1H,d,J=12Hz), 3.80-3.94 (1H,m), 4.04 (1H,s), 4.60 (1H,ddd,J=10Hz,10Hz,4Hz), 5.76 (1H,d,J=8Hz), 6.60 (1H,s), 6.84 (1H,t,J=5Hz), 7.16-7.42 (10H,m) Example 147 (1S,2S)-2-(3-Propyl-2-nonenoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₀H₅₂N₂O₆ Molecular Weight 536.84 Melting Point (°C): wax NMR(δ, CDCl₃): 0.80-0.96 (6H,m), 0.97 (3H,s), 1.04 (3H,s), 1.06-2.21 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 2.40-2.67 (4H,m), 3.28 (1H,d,J=12Hz), 3.49 (2H,td,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.94 (1H,ddd,J=10Hz,8Hz,4Hz), 4.08 (1H,s), 4.64 (1H,ddd,J=10Hz,10Hz,4Hz), 5.42+5.44 (1H,s), 5.67+5.70 (1H,d,J=8Hz), 6.92 (1H,t,J=6Hz) Example 148 (1S,2S)-2-(3-Methyl-2-tridecenoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₂H₅₆N₂O₆ Molecular Weight 564.80 NMR(δ, CDCl₃): 0.88 (3H,t,J=6Hz), 0.97 (3H,s), 1.04 (3H,s), 1.10-2.21 (26H,m), 1.43 (3H,s), 1.47 (3H,s), 2.12 (3H,s), 2.50 (2H,t,J=5Hz), 3.28 (1H,t,J= 12Hz), 3.41-3.57 (2H,m), 3.69 (1H,d,J=12Hz), 3.86-4.01 (1H,m), 4.09 (1H,s), 4.65 (1H,ddd,J= 10Hz,10Hz,4Hz), 5.48 (1H,d,J=8Hz), 6.92 (1H,t,J =5Hz) Example 149 (1S,2S)-2-(2,3-Dimethyl-2-tridecenoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₃H₅₈N₂O₆ Molecular Weight 578.93 NMR(δ, CDCl₃): 0.88 (3H,t,J=6Hz), 0.96 (3H,s), 1.03 (3H,s), 1.07-2.21 (26H,m), 1.43 (3H,s), 1.46 (3H,s), 1.63 (3H,s), 1.75 (3H,s), 2.53 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.36-3.64 (2H,m), 3.69 (1H,d,J=12Hz), 3.88-4.04 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=10Hz,10Hz,4Hz), 5.23+5.58 (1H,d,J=9Hz), 6.92 (1H,t,J=5Hz) Example 150 (1S,2S)-2-(3-Hexylnonanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₃H₆₀N₂O₆ Molecular Weight 580.95 NMR(δ, CDCl₃): 0.87 (6H,t,J=6Hz), 0.96 (3H,s), 1.04 (3H,s), 1.10-2.20 (31H,m), 1.43 (3H,s), 1.47 (3H,s), 2.50 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.36-3.60 (2H,m), 3.69 (1H,d,J=12Hz), 3.88 (1H,m), 4.09 (1H,s), 4.64 (1H,ddd,J=10Hz,10Hz,4Hz), 5.88 (1H,d,J=8Hz), 6.91 (1H,t,J=6Hz) Example 151 (1S,2S)-2-[(E)-3-Phenyl-2-dodecenoyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₆H₅₆N₂O₆ Molecular Weight 612.94 NMR(δ, CDCl₃): 0.55-0.73 (1H,m), 0.87 (3H,t,J=6Hz), 0.96 (3H,s), 1.04 (3H,s), 1.08-2.84 (21H,m), 1.42 (3H,s), 1.47 (3H,s), 2.30-2.43 (2H,m), 2.48 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.33-3.62 (2H,m), 3.69 (1H,d,J=12Hz), 3.70-3.86 (1H,m), 4.08 (1H,s), 4.28 ((1H,ddd,J=10Hz,10Hz,4Hz), 5.06 (1H,d,J=9Hz), 5.85 (1H,s), 6.92 (1H,t,J =6Hz) Example 152 (1S,2S)-2-[(Z)-3-Phenyl-2-dodecenoyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₆H₅₆N₂O₆ Molecular Weight 612.94 NMR(δ, CDCl₃): 0.86 (3H,t,J=7Hz), 0,90 (3H,s), 0.99 (3H,s), 1,03-2.28 (22H,m), 1.39 (3H,s), 1.44 (3H,s), 2.40-2.6 (2H,m), 2.90-3.20 (2H,m), 3.25 (1H,d,J =12Hz), 3.36-3.63 (2H,m), 3.66 (1H,d,J=12Hz), 3.91-4.02 (1H,m), 4.06 (1H,s), 4.65 (1H,ddd,J= 10Hz,10Hz,4Hz), 5.82 (1H,s), 6.04 (1H,d,J=8Hz), 6.91 (1H,t,J=6Hz), 7.29-7.44 (5H,m) Example 153 (1S,2S)-2-[(Z)-3-Phenyl-2-nonenoyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₃H₅₀N₂O₆ Molecular Weight 570.85 NMR(δ, CDCl₃): 0.83 (3H,t,J=7Hz), 0,90 (3H,s), 0.99 (3H,s), 1.08-2.60 (18H,m), 1.39 (3H,s), 1.44 (3H,s), 2.94-3.20 (2H,m), 3.25 (1H,d,J=12Hz), 3.38-3.61 (2H,m), 3.66 (1H,d,J=12Hz), 3.90-4.04 (1H,m), 4.06 (1H,s), 4.65 (1H,ddd,J=11Hz,11Hz,4Hz), 5.82 (1H,s), 6.01 (1H,d,J=6Hz), 6.91 (1H,t,J= 6Hz), 7.29-7.44 (5H,m) Example 154 (1S,2S)-2-[(E)-3-Phenyl-2-nonenoyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₃H₅₀N₂O₆ Molecular Weight 570.85 NMR(δ, CDCl₃): 0.55-0.72 (1H,m), 0.85 (3H,t,J=7Hz), 0,96 (3H,s), 1.04 (3H,s), 0.88-1.99 (15H,m), 1.42 (3H,s), 1.47 (3H,s), 2.29-2.34 (2H,m), 2.48 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.32-3.61 (2H,m), 3.69 (1H,d,J=12Hz), 3.71-3.84 (1H,m), 4.08 (1H,s), 4.28 (1H,ddd,J=10Hz,10Hz,4Hz), 5.07 (1H,d,J=9Hz), 5.85 (1H,s), 6.92 (1H,t,J=6Hz), 7.13-7.45 (5H,m) Example 155 (1S,2S)-2-(2-Hexylideneoctanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₂H₅₀N₂O₆ Molecular Weight 564.90 NMR(δ, CDCl₃): 0.87 (3H,t,J=8Hz), 0.88 (3H,t,J=7Hz), 0,96 (3H,s), 1.03 (3H,s), 1.07-2.26 (26H,m), 1.42 (3H,s), 1.46 (3H,s), 2.40-2.66 (2H,m), 3.28 (1H,d,J=12Hz), 3.37-3.64 (2H,m), 3.69 (1H,d,J =12Hz), 3.90-4.06 (1H,m), 4.07 (1H,s), 4.70 (1H,ddd,J=10Hz,10Hz,4Hz), 5.38 (1H,t,J=7Hz), 5.61 (1H,d,J=8Hz), 6.91 (1H,t,J=6Hz) Example 156 (1S,2S)-2-(2-Hexylideneoctanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₂H₅₆N₂O₆ Molecular Weight 564.90 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.89 (3H,t,J=7Hz), 0,96 (3H,s), 1.03 (3H,s), 1.06-2.33 (26H,m), 1.42 (3H,s), 1.47 (3H,s), 2.40-2.66 (2H,m), 3.28 (1H,d,J=12Hz), 3.32-3.62 (2H,m), 3.69 (1H,d,J =12Hz), 3.86-4.02 (1H,m), 4.07 (1H,s), 4.74 (1H,ddd,J=11Hz,11Hz,4Hz), 5.82 (1H,d,J=8Hz), 6.01 (1H,t,J=7Hz), 6.90 (1H,t,J=6Hz) Example 157 (1S,2S)-2-(N-Benzyl-N-nonylcarbamoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₅H₅₇N₃O₆ Molecular Weight 615.86 Melting Point (°C): oil NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.05-2.23 (22H,m), 1.42 (3H,s), 1.46 (3H,s), 2.32-2.53 (2H,m), 3.17 (2H,t,J=7Hz), 3.25-3.39 (1H,m), 3.28 (1H,d,J=12Hz), 3.42-3.55 (1H,m), 3.68 (1H,d,J=12Hz), 3.71-3.83 (1H,m), 4.07 (1H,s), 4.36 (1H,d,J=16Hz), 4.46 (1H,d,J=16Hz), 4.47 (1H,d,J=8Hz), 4.62 (1H,ddd,J=11Hz,11Hz, 4Hz), 4.87 (1H,t,J=6Hz), 7.20-7.37 (5H,m) Example 158 (1S,2S)-2-(2-Benzylundecanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₅H₅₆N₂O₆ Molecular Weight 600.84 Melting Point (°C): oil NMR(δ), CDCl₃): 0.88 (3H,t,J=7Hz), 1.02 (3H,s), 1.08 (3H,s), 1.12-2.24 (25H,m), 1.46 (3H,s), 1.54 (3H,s), 2.61 (1H,dd,J=13Hz,5Hz), 2.92 (1H,dd,J=13Hz, 9Hz), 3.22 (1H,dd,J=18Hz,5Hz), 3.31 (1H,d,J= 12Hz), 3.70-3.84 (1H,m), 3.71 (1H,d,J=12Hz), 3.94 (1H,dd,J=18Hz,7Hz), 4.13 (1H,s), 4.62 (1H,ddd,J=11Hz,11Hz,4Hz), 5.51 (1H,d,J=8Hz), 6.64-6.72 (1H,m), 7.14-7.21 (3H,m), 7.23-7.32 (2H,m) Example 159 (1S,2S)-2-(2-Heptylnonanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₄H₆₂N₂O₆ Molecular Weight 594.88 Melting Point (°C): wax NMR(δ, CDCl₃): 0.87 (6H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.08-2.21 (33H,m), 1.43 (3H,s), 1.47 (3H,s), 2.41-2.58 (2H,m), 3.28 (1H,d,J=12Hz), 3.51 (2H,dt,J=6Hz,6Hz), 3.69 (1H,d,J=12Hz), 3.82-3.95 (1H,m), 4.08 (1H,s), 4.68 (1H,ddd,J=11Hz, 11Hz,4Hz), 5.80 (1H,d,J=8Hz), 6.91 (1H,t,J=6Hz) Example 160 (1S,2S)-2-[(1-Heptyloctyl)carbamoyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₄H₆₃N₃O₆ Molecular Weight 609.89 Melting Point (°C): wax NMR(δ, CDCl₃): 0.87 (6H,t,J=7Hz), 0.96 (3H,s), 1.03 (3H,s), 1.08-2.28 (32H,m), 1.44 (3H,s), 1.47 (3H,s), 2.38-2.57 (2H,m), 3.28 (1H,d,J=12Hz), 3.31-3.42 (1H,m), 3.54-3.82 (3H,m), 3.69 (1H,d,J=12Hz), 4.10 (1H,s), 4.48 (1H,brs), 4.55 (1H,ddd,J=11Hz, 11Hz,4Hz), 4.83 (1H,brs), 6.90 (1H,t,J=6Hz) Example 161 (1S,2S)-2-(2-Benzyl-3-phenylpropanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₄H₄₆N₂O₆ Molecular Weight 578.75 Melting Point (°C): calomel NMR(δ, CDCl₃): 0.94 (3H,s), 0.95-2.23 (10H,m), 1.03 (3H,s), 1.42 (3H,s), 1.46 (3H,s), 2.43-2.56 (1H,m), 2.68-3.09 (4H,m), 3.15-3.32 (2H,m), 3.27 (1H,d,J=12Hz), 3.59-3.69 (1H,m), 3.68 (1H,d,J=12Hz), 4.06 (1H,s), 4.35 (1H,ddd,J=11Hz,11Hz,4Hz), 5.38 (1H,d,J=8Hz), 6.77 (1H,t,J=6Hz), 7.12-7.28 (10H,m) Example 162 (1S,2S)-2-[(5-Phenyl-2-(3-phenylpropyl)pentanoyl)]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₃₈H₅₄N₂O₆ Molecular Weight 634.86 Melting Point (°C): calomel NMR(δ, CDCl₃): 0.93 (3H,s), 0.98-2.27 (19H,m), 1.02 (3H,s), 1.41 (3H,s), 1.46 (3H,s), 2.48-2.64 (4H,m), 3.12-3.28 (2H,m), 3.27 (1H,d,J=12Hz), 3.67 (1H,d,J=12Hz), 3.78-3.91 (1H,m), 4.05 (1H,s), 4.59 (1H,ddd,J=11Hz,11Hz,4Hz), 5.87 (1H,d,J= 8Hz), 6.75 (1H,t,J=6Hz), 7.11-7.30 (10H,m) Example 163 (1S,2S)-2-[6-Phenyl-2-(4-phenylbutyl)hexanoyl]aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₄₀H₅₈N₂O₆ Molecular Weight 662.91 Melting Point (°C): oil NMR(δ, CDCl₃): 0.84-2.14 (21H,m), 0.94 (3H,s), 1.01 (3H,s), 1.41 (3H,s), 1.45 (3H,s), 2.32-2.61 (6H,m), 3.27 (1H,d,J=8Hz), 3.37-3.53 (2H,m), 3.67 (1H,d,J=8Hz), 3.78-3.92 (1H,m), 4.06 (1H,s), 4.62 (1H,ddd,J=11Hz,11Hz,4Hz), 5.82 (1H,d,J= 8Hz), 6.86 (1H,t,J=6Hz), 7.11-7.29 (10H,m) Example 164 (1S,2S)-2-[2-(p-tert-Butylbenzyl)-3-(4-tertbutylphenyl)propanoyl)aminocyclohexane-1-yl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Melecular Formula C₄₂H₆₂N₃O₆ Molecular Weight 690.97 Melting Point (°C): calomel NMR(δ, CDCl₃): 0.94 (3H,s), 1.02 (3H,s), 1.05-1.84 (8H,m), 1.28 (9H,s), 1.29 (9H,s), 1.41 (3H,s), 1.46 (3H,s), 2.12-2.34 (2H,m), 2.48-2.58 (1H,m), 2.66-3.04 (4H,m), 3.27 (1H,d,J=12Hz), 3.33 (2H,dt,J=6Hz,6Hz), 3.61-3.73 (1H,m), 3.68 (1H,d,J=12Hz), 4.06 (1H,s), 4.38 (1H,ddd,J= 11Hz,11Hz,4Hz), 5.32 (1H,d,J=8Hz), 6.83 (1H,t,J=6Hz), 7.06 (2H,d,J=8Hz), 7.11 (2H,d,J =8Hz), 7.26 (2H,d,J=8Hz), 7.28 (2H,d,J=8Hz) Example 165 Preparation of (S)-2-Oleoylaminomethyl-1-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}pyrrolidine 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (530 mg) was added to a solution of 910 mg of (S)-2-oleylamino-methylpyrolidine and 650 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid in 10 ml of methylene chloride under ice cooling. The mixture was stirred at room temperature for 18 hours. The reaction mixture was washed with water and dried over anhydrous sodium sulfate, followed by removal of the solvent by vacuum evaporation. Then, the residue was purified by silica gel column chromatography to obtain 1.05 g of the title compound (yield: 59 %). Property : oily Specific rotary power [α] D : +5.2°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3336, CO 1656 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 605.4746 Found 605.4747 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.19-1.39 (20H,m), 1.42 (3H,s), 1.46 (3H,s), 1.53-1.82 (3H,m), 1.85-2.09 (7H,m), 2.16 (2H,t,J=7Hz), 2.44-2.62 (2H,m), 3.13-3.23 (1H,m), 3.28 (1H,d,J=12Hz), 3.39-3.60 (5H,m), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 4.21-4.28 (1H,m), 5.29-5.40 (2H,m), 7.09 (1H,t,J=6Hz), 7.24 (1H,brs) Example 166 Preparation of (S)-2-(Oleoylamino)methyl-1-{3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanoyl}pyrrolidine A solution of 500 mg of (S)-2-(Oleoylamino)methyl-1-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}pyrrolidine in a mixed solvent composed of 20 ml of acetic acid and 10 ml of water was stirred at room temperature for 16 hours. Then, 20 ml of ethyl acetate and 20 ml of water were added thereto, and the organic layer was separated. The organic layer was washed with water, and dried over anhydrous sodium sulfate. After removing the solvent by evaporation, the residue obtained was subjected to silica gel column chromatography for purification to obtain 397 mg of the title compound (yield: 85 %). Property : oily Specific Rotary Power [α] D : -5.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3324, CO 1650 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 565.4454 Found 565.4449 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.92 (3H,s), 1.02 (3H,s), 1.21-1.39 (20H,m), 1.71-1.84 (1H,m), 1.53-1.67 (2H,m), 1.85-2.09 (7H,m), 2.17 (2H,t,J=7Hz), 2.45-2.87 (4H,m), 3.13-3.75 (8H,m), 3.99 (1H,s), 3.39-3.68 (5H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.19-4.29 (1H,m), 5.29-5.40 (2H,m), 6.85-7.07 (1H,brs), 7.36-7.44 (1H,m) Example 167 Preparation of (R)-2-Oleoylaminomethyl-1-{3-[N-(2,2,5,5-tetrmethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}pyrrolidine (R)-2-Oleoylaminomethylpyrrolidine (910 mg) and 650 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 165 to obtain 1.24 g of the title compound (yield: 82 %). Property : oily Specific rotary power [α] D : +41.5°(C=1.0, CHCl₃) IR(cm⁻¹, νneat): NH 3336, CO 1654, Mass Spectrometric analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 605,4747 Found 605,4787 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.21-1.39 (20H,m), 1.43 (3H,s), 1.46 (3H,s), 1.55-1.82 (3H,m), 1.87-2.09 (7H,m), 2.17 (2H,t,J=7Hz), 2.53 (2H,t,J=6Hz), 3.12-3.21 (1H,m), 3.28 (1H,t,J=12Hz), 3.39-3.68 (5H,m), 3.68 (1H,t,J=12Hz), 4.08 (1H,s), 4.20-4.28 (1H,m), 5.28-5.40 (2H,m), 7.11 (1H,t,J=6Hz), 7.24 (1H,brs) Example 168 Preparation of 3-Oleoylamino-1-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperidine 3-Oleoylaminopiperidine (1.02 g) and 0.78 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 165 to obtain 1.61 g of the title compound (yield: 89 %). Property : oil Specific Rotary Power [α] D : +25.3°(C=1.0, CHCl₃) IR(cm⁻¹, νneat): NH 3316, CO 1652 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 605,4767 Found 605,4749 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.04 (3H,s), 1.18-1.39 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.49-2.08 (10H,m), 2.16 (2H,t,J=7Hz), 2.56 (2H,t,J=6Hz), 3.01-3.15 (1H,m), 3.16-3.66 (4H,m), 3.28 (1H,d,J=12Hz), 3.68 (1H,d,J=12Hz), 3.69-4.08 (2H,m), 4.07 (1H,s), 5.29-5.40 (2H,m), 7.01-7.11 (1H,d,J=6Hz) Example 169 Preparation of 3-Oleoylamino-1-{3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propanoyl}piperidine 3-Oleoylamino-1-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperidine (1.61 g) was reacted in the same manner as in Exaple 166 to obtain 1.1 g of the title compound (yield: 73 %). Property : oil Specific Rotary Power [α] D : +10.4°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3316, ν CO 1650 Mass Spectrometric Analysis Molecular Formula C₃₅H₅₉N₃O₅ Calculated 565.4454 Found 565.4446 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.93-0.95 (3H,s), 1.03 (3H,s), 1.21-1.38 (20H,m), 1.48-2.09 (10H,m), 2.15 (2H,t,J=7Hz), 2.57 (2H,t,J=6Hz), 3.05-3.98 (7H,m), 3.47 (1H,d,J=12Hz), 3.51 (1H,d,J=12Hz), 3.95 (1H,m), 5.29-5.40 (2H,m), 5.61-5.86 (1H,brs), 7.23 (1H,brs) Example 170 Preparation of 1-Oleoyl -3-{3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxo-butyl)amino]propanoyl}aminopiperidines A and B Oleoyl chloride (945 mg) was added to a solution of 942 mg of 3-[3-(2,4-dihydroxy-3,3-dimethyl-1-oxo-butylamino)propanyl]aminopiperidine and 1.06 g of sodium carbonate in a mixed solvent composed of 20 ml of water and 20 ml of ethyl acetate under ice cooling and the mixture was stirred for additional 30 minutes. Then the aqueous layer was removed. The organic layer was washed with brine and dried over anhydrous sodium sulfate. After removing the solvent by evaporation, the residue was purified by silica gel column chromatography to obtain two diastereomers A and B, respectively, the title compound, in amount of 390 mg (yield: 22 %) and 409 mg (yield: 23 %), respectively. A Property : oily Specific Rotary Power [α] D : +22.5°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3324, ν CO 1652 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₉N₃O₅ Calculated 565.4453 Found 565.4433 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.91 (3H,s), 1.04 (3H,s), 1.22-1.38 (20H,m), 1.52-2.09 (10H,m), 2.25-2.53 (4H,m), 2.65-3.70 (9H,m), 3.98 (1H,brs), 4.04-4.31 (2H,m), 5.28-5.40 (2H,m), 5.94 (1H,brs), 7.50 (1H,brs) B Property : oil Specific Rotary Power [α] D : +7.6°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3320, ν CO 1652 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₉N₃O₅ Calculated 565.4453 Found 565.4461 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.03 (3H,s), 1.22-1.38 (20H,m), 1.52-2.09 (10H,m), 2.25-2.80 (6H,m), 3.10-4.05 (1H,s), 5.29-5.40 (2H,m), 6.23 (1H,brs), 7.50 (1H,brs) Example 171 Preparation of 1-Oleoyl-3-[3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanoyl]aminopiperidine-A To a solution of 180 mg of 1-oleoylamino-3-[3-(2,4-dihydroxy-3,3-dimethyl-1-oxobutylamino)propanoyl]aminopiperidine-A obtained in Example 170 in 10 ml of acetone was added 10 mg of p-toluenesulfonic acid, and the mixture was stirred at room temperature for 10 hours. After adding a saturated aqueous solution of sodium hydrogen carbonate thereto, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous sodium sulfate, followed by removal of the solvent. The residue was subjected to silica gel column chromatography to obtain 176 mg of the title compound (yield: 91 %). Property : oily Specific Rotary Power [α] D : +30.6°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1652, 1636 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 605.4767 Found 605.4789 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.21-1.38 (20H,m), 1.43 (3H,s), 1.47 (3H,s), 1.49-1.77 (5H,m), 1.81-2.08 (5H,m), 2.34 (2H,t,J=7Hz), 2.36-2.49 (2H,m), 2.98-3.16 (1H,m), 3.28 (1H,d,J=12Hz), 3.32-3.72 (4H,m), 3.70 (1H,d,J=12Hz), 3.78-4.04 (2H,m), 4.08 (1H,s), 5.29-5.40 (2H,m), 5.99-6.16 (1H,m), 7.02 (1H,brs) Example 172 Preparation of 1-Oleoyl-3-[3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanoyl]aminopiperidine-B 1-Oleoylamino-3-[3-(2,4-dihydroxy-3,3-dimethyl-1-oxo-butylamino)propanoyl]aminopiperidine-B obtained in Example 170 (238 mg) was reacted in the same manner as in Example 171 to obtain 206 mg of the title compound. Property : oily Specific Rotary Power [α] D : +16.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1654 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 605.4767 Found 605.4776 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.05 (3H,s), 1.18-1.38 (20H,m), 1.42 (3H,s), 1.47 (3H,s), 1.49-2.08 (10H,m), 2.34 (2H,t,J=7Hz), 2.37-2.50 (2H,m), 2.90-3.07 (1H,m), 3.29 (1H,d,J=12Hz), 3.32-3.73 (4H,m), 3.69 (1H,d,J=12Hz), 3.76-4.11 (2H,m), 4.07 (1H,s), 5.29-5.41 (2H,m), 5.97-6.11 (1H,m), 7.02 (1H,brs) Example 173 Preparation of 1-Oleoyl-4-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino]propionate A solution of 1.83 g of 1-oleoyl-4-hydroxy-piperidine, 1.3 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid, 1.03 g of dicyclohexylcarbodiimide and 0.61 g of 4-(N,N-dimethylamino)pyridine in 60 ml of toluene was heated under reflux for one night. After completion of the reaction, the reaction mixture was cooled and precipitates were removed. Then, the organic layer was washed sequentially with water, 1N hydrochloric acid and brine, and dried over anhydrous sodium sulfate. After removing the solvent by evaporation, the residue was subjected to silica gel column chromatography to obtain 1.95 g of the title compound (yield: 65 %). Property : oily IR(cm⁻¹, neat): ν CO 1740, 1660 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₂N₂O₆ Calculated 606.4606 Found 606.4587 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.16-1.40 (19H,m), 1.43 (3H,s), 1.46 (3H,s), 1.50-1.77 (6H,m), 1.76-2.04 (6H,m), 3.32 (2H,t,J=6Hz), 2.58 (2H,t,J=6Hz), 3.29 (1H,d,J=12Hz), 3.26-3.70 (4H,m), 3.69 (1H,d,J=12Hz), 3.88-4.00 (1H,m), 4.08 (1H,s), 4.96-5.06 (1H,m), 5.30-5.42 (2H,m), 6.88-6.96 (1H,m) Example 174 Preparation of 1-Oleoyl-4-piperidinyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate 1-Oleoyl-4-piperidine 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (1.51 g) was reacted in the same manner as in Example 166 to obtain 1.37 g of the title compound (yield: 97 %). Property : oily IR(cm⁻¹, neat): ν NH 3436, ν CO 1740, 1658 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₈N₂O₆ Calculated 566.4294 Found 566.4318 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.92 (3H,s), 1.02 (3H,s), 1.02 (3H,s), 1.20-1.40 (21H,m), 1.56-1.72 (4H,m), 1.80-2.10 (5H,m), 2.32 (2H,t,J=7Hz), 2.59 (2H,t,J=6Hz), 3.20-4.10 (10H,m), 4.96-5.06 (1H,m), 4.96-5.06 (1H,m), 5.30-5.42 (2H,m), 7.14-7.24 (1H,m) Example 175 Preparation of 1-Oleoyl-4-piperidinyl 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate Acetic anhydride (10 ml) was added to a solution of 530 mg of 1-oleoyl-4-piperidine 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxo-butyl)amino]propionate in 5 ml of ypridine, and the mixture was stirred at room temperature for 15 hours. The reaction mixture was poured into ice water, and extracted with ethyl acetate. The organic layer was washed sequentially with a saturated aqueous sodium hydrogen carbonate solution, with water and then with brine, followed by drying over anhydrous sodium sulfate. After removing the solvent by vacuum evaporation, the residue was subjected to silica gel column chromatography to obtain 610 mg of the title compound. Property : oily IR(cm⁻¹, neat): ν CO 1746, 1642 Mass Spectrometiric Analysis Molecular Formula C₃₆H₆₂N₂O₈ Calculated 650.4505 Found 650.4502 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.02 (3H,s), 1.07 (3H,s), 1.20-1.40 (20H,m), 1.56-1.70 (5H,m), 1.80-2.08 (6H,m), 2.07 (3H,s), 2.15 (2H,t,J=6Hz), 3.26-3.70 (6H,m), 3.83 (1H,d,J=11Hz), 3.82-3.94 (1H,m), 4.04 (1H,d,J=11Hz), 4.96 (1H,s), 4.93-5.02 (1H,m), 5.30 (2H,m), 6.52-6.60 (1H,m) Example 176 Preparation of 1-Oleoyl-3-piperidinyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate 1-Oleoyl-3-hydroxypiperidine (3.30 g) and 2.33 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 173 to obtain crude 1-oleoyl-3-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate. This compound was reacted in the same manner as in Example 166 to obtain two disatereomers-A and -B of the title compound in amount of 1.25 g (45 %) and 1.36 g (yield: 49 %). A Property : oily Specific Rotary Power [α] D : +19.5°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1740, 1652 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₈N₂O₆ Calculated 566.4294 Found 566.4297 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.07 (3H,s), 1.22-1.39 (20H,m), 1.45-2.09 (10H,m), 2.31 (2H,t,J=7Hz), 2.33-3.18 (6H,m), 3.29-3.58 (3H,m), 3.70-3.89 (3H,m), 4.02 (1H,brs), 4.81-4.93 (2H,m), 5.29-5.41 (2H,m), 7.38 (1H,brs), B Property : oily Specific Rotary Power [α] D : +32.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1740, 1650 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₈N₂O₆ Calculated 566.4294 Found 566.4394 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.00 (3H,s), 1.06 (3H,s), 1.22-1.38 (20H,m), 1.52-2.08 (10H,m), 2.15-2.63 (4H,m), 2.92-3.84 (7H,m), 4.00 (1H,s), 4.47-4.58 (1H,m), 4.96 (1H,brs), 5.29-5.40 (2H,m), 7.42 (1H,brs) Example 177 Preparation of 1-Oleoyl-3-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate-A 1-Oleoyl-3-piperidinyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxo-butyl)amino]propionate-A (568 mg) was reacted in the same manner as in Example 171 to obtain 479 mg of the title compound (yield: 79 %). Property : oily Specific Rotary Power [α] D : +18.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1740, 1678, 1650 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₂N₂O₆ Calculated 606.4607 Found 606.4635 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.04 (3H,s), 1.21-1.38 (20H,m), 1.42 (3H,s), 1.46 (3H,s), 1.40-2.09 (10H,m), 2.30 (2H,t,J=7Hz), 2.45-2.63 (2H,m), 3.27 (1H,d,J=12Hz), 3.32-3.70 (6H,m), 3.66 (1H,d,J=12Hz), 4.07 (1H,s), 4.81 (1H,brs), 5.29-5.40 (2H,m), 6.79-7.02 (1H,brs) Example 178 Preparation of 1-Oleoyl-3-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate-B 1-Oleoyl-3-piperidinyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxo-butyl)amino]propionate-B (567 mg) was reacted in the same manner as in Example 171 to obtain 490 mg of the title compound (yield: 81 %). Property : oily Specific Rotary Power [α] D : +22.8°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1740, 1680, 1652 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₂N₂O₆ Calculated 606,4607 Found 606.4607 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.98 (3H,s), 1.05 (3H,s), 1.21-1.38 (20H,m), 1.42 (3H,s), 1.45 (3H,s), 1.50-2.05 (10H,m), 2.30 (2H,t,J=7Hz), 2.54 (2H,t,J=6Hz), 3.24 (1H,d,J=12Hz), 3.32-3.72 (6H,m), 3.66 (1H,d,J=12Hz), 4.06 (1H,s), 4.75-4.85 (1H,m), 5.29-5.40 (2H,m), 7.81-7.93 (1H,m) Example 179 Preparation of 1-Oleoyl-2-(2S)-pyrrolidinylmethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (S)-1-Oleoyl-2-pyrrolidinemethanol (1.83 g) and 1.30 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 173 to obtain 2.24 g of the title compound (yield: 74 %). Property : oily Specific Rotary Power [α] D : +0.5°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1740, 1680, 1652 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₂N₂O₆ Calculated 606,4607 Found 606.4589 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.04 (3H,s), 1.20-1.40 (20H,m), 1.43 (3H,s), 1.46 (3H,s), 1.56-1.72 (2H,m), 1.75-2.09 (8H,m), 2.25 (2H,t,J=7Hz), 2.57 (2H,t,J=6Hz), 3.28 (1H,d,J= 12Hz), 3.35-3.64 (4H,m), 3.68 (1H,d,J=12Hz), 4.05-4.28 (3H,m), 4.31-4.41 (1H,m), 5.29-5.41 (2H,m), 6.90-7.04 (1H,m) Example 180 Preparation of 1-Oleoyl-2-(2R)-pyrrolidinylmethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (R)-1-Oleoyl-2-pyrrolidinemethanol (1.46 g) and 1.04 g of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 173 to obtain 1.62 g of the title compound (yield: 67 %). Property : oily Specific Rotary Power [α] D : +44.9°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1742, 1682, 1652 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₂N₂O₆ Calculated 606.4607 Found 606.4605 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.97 (3H,s), 1.04 (3H,s), 1.19-1.39 (20H,m), 1.43 (3H,s), 1.46 (3H,s), 1.55-2.09 (10H,m), 2.26 (2H,t,J=7Hz), 2.57 (2H,t,J=6Hz), 3.22 (1H,d,J=12Hz), 3.36-3.70 (4H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.09-4.24 (2H,m), 4.30-4.43 (1H,m), 5.29-5.40 (2H,m), 6.92-7.05 (1H,m) Example 181 Preparation of 1-Stearoyl-2-(2S)-pyrrolidinylmethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (S)-1-Stearoyl-2-pyrrolidinemethanol (367 mg) and 259 mg of 3-[N-2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 173 to obtain 470 mg of the title compound (yield: 77 %). Property : oily Specific Rotary Power [α] D : -5.10°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν CO 1742, 1650 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₄N₂O₆ Calculated 608.4764 Found 608.4760 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.18-1.37 (24H,m), 1.43 (3H,s), 1.46 (3H,s), 1.53-2.10 (10H,m), 2.25 (3H,t,J=7Hz), 2.56 (2H,t,J=6Hz), 3.28 (1H,d,J=12Hz), 3.35-3.62 (4H,m), 3.68 (1H,d,J=12Hz), 4.08 (1H,s), 4.12 (1H,dd,J=11Hz,4Hz), 4.23 (1H,dd,J=11Hz,4Hz), 4.32-4.40 (1H,m), 6.08 (1H,t,J=6Hz) Example 182 Preparation of 1-Linoleoyl-2-(2S)-pyrrolidinylmethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (S)-1-Linoleoyl-2-pyrrolidinemethanol (363 mg) and 259 mg of 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionic acid were reacted in the same manner as in Example 173 to obtain 433 mg of the title compound (yield: 70 %). Property : oily Specific Rotary Power [α] D : +2.30°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1680, 1652 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₀N₂O₆ Calculated 604.4451 Found 604.4452 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.22-1.41 (14H,m), 1.43 (3H,s), 1.46 (3H,s), 1.56-2.09 (10H,m), 2.25 (2H,t,J=7Hz), 2.56 (2H,t,J=6Hz), 2.77 (2H,t,J=6Hz), 3.28 (1H,d,J =12Hz), 3.37-3.63 (4H,m), 4.08 (1H,s), 4.11 (1H,dd,J=11Hz,4Hz), 4.23 (1H,dd,J=11Hz,4Hz), 4.31-4.40 (1H,m), 5.28-5.43 (4H,m), 6.98 (1H,t,J=6Hz) Example 183 Preparation of 1-Oleoyl-2-(2S)-pyrrolidinylmethyl 3-[N-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionate 1-Oleoyl-2-(2S)-pyrrolidinylmethyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (1.5 g) was reacted in the same manner as in Example 166 to obtain 1.27 g of the title compound (yield: 91 %). Property : oily Specific Rotary Power [α] D : +13.4°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3312, ν CO 1742, 1650 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₈N₂O₆ Calculated 566.4294 Found 566.4301 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.94 (3H,s), 1.04 (3H,s), 1.21-1.40 (20H,m), 1.54-1.68 (2H,m), 1.69-1.86 (1H,m), 1.88-2.09 (7H,m), 2.10-2.38 (3H,m), 2.40-2.63 (2H,m), 3.33-3.71 (6H,m), 4.00 (1H,m), 4.03-4.15 (2H,m), 4.38-4.50 (1H,m), 5.28-5.40 (2H,m), 7.30-7.52 (1H,m) Example 184 Preparation of 1-Oleoyl-2-(2S)-pyrrolidinylmethyl 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionate 1-Oleoyl-2-(2S)-pyrrolidinylmethyl 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutylamino)amino]propionate (556 mg) was reacted int he same manner as in Example 175 to obtain 463 mg of the title compound (yield: 71 %). Property : oily Specific Rotary Power [α] D : -0.40°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH , ν CO 2748, 1646 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₂N₂O₈ Calculated 650.4506 Found 650.4500 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.02 (3H,s), 1.07 (3H,s), 1.22-1.38 (20H,m), 1.55-1.67 (2H,m), 1.70-1.85 (1H,m), 1.88-2.08 (7H,m), 2.07 (3H,m), 2.14 (3H,s), 2.26 (2H,t,J=7Hz), 2.43-2.59 (2H,m), 3.35-3.68 (4H,m), 3.84 (1H,d,J=12Hz), 4.04 (1H,d,J=12Hz), 4.15 (2H,d,J=6Hz), 4.37-4.45 (1H,m), 4.97 (1H,s), 5.28-5.40 (2H,m), 6.89-6.96 (1H,m) Example 185 Preparation of (S)-1-Oleoyl-2-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino-1-oxopropyl]aminomethyl}pyrrolidine Pyridine (1 ml) was added to a solution of 321 mg of (S)-2-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino-1-oxopropyl]aminomethyl}pyrrolidine in 20 ml of methylene chloride. Under ice cooling, a solution of 271 mg of oleoyl chloride in 5 ml of methylene chloride was added portion-wise to the mixture, and the mixture thus formed was stirred for 3 hours as it was. After completion of the reaction, the reaction mixture was washed with water, and dried over anhydrous sodium sulfate. After removal of the solvent by evaporation, the residue was subjected to silica gel column chromatography to obtain 166 mg of the title compound (yield: 30 %). Property : oily Specific Rotary Power [α] D : +3.90°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3324, ν CO 1676 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 605.4767 Found 605.4778 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.99 (3H,s), 1.04 (3H,s), 1.18-1.39 (20H,m), 1.42 (4H,s), 1.47 (3H,s), 1.57-1.80 (3H,m), 1.88-2.09 (7H,m), 2.27 (2H,t,J=7Hz), 2.23-2.45 (2H,m), 3.13-3.23 (1H,m), 3.28 (1H,d,J=11Hz), 3.40-3.64 (5H,m), 3.68 (1H,d,J=11Hz), 4.07 (1H,s), 4.23-4.31 (1H,m), 5.29-5.40 (2H,m), 7.12 (1H,t,J=6Hz), 7.50-7.62 (1H,m) Example 186 Preparation of (R)-1-Oleoyl-2-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino-1-oxopropyl]aminomethyl}pyrrolidine Triethylamine (2 ml) was added to a solution of 821 mg of (R)-2-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino-1-oxopropyl]aminomethyl}pyrrolidine in 40 ml of methylene chloride. Under ice cooling, a solution of 697 mg of oleoyl chloride in 10 ml of methylene chloride was added portion-wise to the mixture, and the mixture thus formed was stirred for 3 hours at it was. After completion of the reaction, the reaction mixture was washed with water, and dried over anhydrous sodium sulfate. After removal of the solvent by evaporation, the residue was subjected to silica gel column chromatography to obtain 1.20 g of the title compound (yield: 87 %). Property : oily Specific Rotary Power [α] D : +40.7°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3328, ν CO 1656 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₃N₃O₅ Calculated 605.4767 Found 606.4757 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.21-1.39 (20H,m), 1.42 (3H,s), 1.47 (3H,s), 1.56-1.80 (3H,m), 1.88-2.09 (7H,m), 2.27 (2H,t,J=7Hz), 2.40 (2H,t,J=6Hz), 3.12-3.20 (1H,m), 3.27 (1H,d,J=12Hz), 3.41-3.64 (5H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 4.24-4.33 (1H,m), 5.29-5.40 (2H,m), 7.12 (1H,t,J=6Hz), 7.60 (1H,brs) Example 187 1-(2-Methyllauroyl)4-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₀H₅₄N₂O₆ Molecular Weight 538.77 Mass Spectrometric Analysis Calculated 538.3981 Found 538.3966 Melting Point (°C) : oil Specific Rotary Power [α]²⁸ D +25.7°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1736 NMR( , CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.10 (3H,d,J=7Hz), 1.17-1.33 (16H,m), 1.43 (3H,s), 1.46 (3H,s), 1.52-1.97 (6H,m), 2.58 (2H,t,J=6Hz), 1.60-1.76 (1H,m). 3.28 (2H,d,J=12Hz), 3.31-4.03 (6H,m), 3.69 (1H,d,J= 12Hz), 4.08 (1H,s), 4.98-5.08 (1H,m), 6.93 (1H,t,J=5Hz) Example 188 1-(1-Decylcyclobutanecarbonyl)-4-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₂H₅₆N₂O₆ Molecular Weight 564.81 Mass Spectrometric Analysis Calculated 564.4138 Found 564.4119 Melting Point (°C) : oil Specific Rotary Power: [α]²⁸ D +23.7°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1738 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.16-1.37 (16H,m), 1.42 (3H,s), 1.46 (3H,s) 1.52-1.98 (10H,m), 2.42-2.54 (2H,m), 2.58 (2H,t,J=6Hz), 3.11-3.98 (6H,m), 3.28 (1H,d,J= 12Hz), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 4.96-5.05 (1H,m), 6.92 (1H,t,J=5Hz) Example 189 1-(1-Decylcyclobutanecarbonyl)-3-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino)propionate Molecular Formula C₃₂H₅₆N₂O₆ Molecular Weight 564.81 Mass Spectrometric Analysis Calculated 564.4138 Found 564.4153 Melting Point (°C) : oil Specific Rotary Power: [α]²⁷ D +21.4°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1740 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.97 (3H,s), 1.04 (3H,s), 1.12-1.35 (16H,m), 1.43 (3H,s), 1.46 (3H,s) 1.50-2.02 (10H,m), 2.39-2.60 (4H,m), 2.90-3.75 (6H,m), 3.28 (1H,d,J=12Hz), 3.69 (1H,d,J=12Hz), 4.08 (1H,s), 4.65-4.92 (1H,m), 6.92-7.08 (1H,m) Example 190 1-(2-Benzylundecanoyl)-4-piperidinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₅₆N₂O₆ Molecular Weight 600.84 Mass Spectrometric Analysis Calculated 600,4138 Found 600,4122 Melting Point (°C) : oil Specific Rotary Power: [α]²⁸ D +22.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1734 NMR(δ, CDCl₃): 55°C 0.88 (3H,t,J=7Hz), 0.95 (3H,s), 1.04 (3H,s), 1.19-1.85 (20H,m), 1.41 (3H,s), 1.44 (3H,s) 2.51 (2H,t,J=6Hz), 2.66-2.77 (1H,m), 2.85-3.64 (8H,m), 3.27 (1H,d,J=12Hz), 3.66 (1H,d,J=12Hz), 4.05 (1H,s), 4.78-4.88 (1H,m), 4.78-6.87 (1H,m), 7.13-7.28 (5H,m) Example 191 1-(1-Benzyldecyl)carbamoyl-4-piperazinyl 3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate Molecular Formula C₃₅H₅₇N₃O₆ Molecular Weight 615.86 Mass Spectrometric Analysis Calculated 615.4247 Found 615,4222 Melting Point (°C) : wax Specific Rotary Power: [α]²⁸ D +21.8°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1734 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.16-1.38 (16H,m), 1.42 (3H,s), 1.46 (3H,s) 1.48-1.89 (4H,m), 2.57 (2H,t,J=6Hz), 2.72-2.87 (2H,m), 3.05-3.21 (2H,m), 3.28 (1H,d,J=12Hz), 3.41-3.66 (4H,m), 3.69 (1H,d,J=12Hz), 4.01-4.07 (1H,m), 4.08 (1H,s), 4.15-4.23 (1H,m), 4.91-4.99 (1H,m), 6.92 (1H,t,J=5Hz), 7.14-7.32 (5H,m) Example 192 Preparation of 1-Oleoyl-4-{1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl}piperazine 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (530 mg) was added to a solution of 980 mg of 1-oleylamino-piperazine and 836 mg of 3-[N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid in 10 ml of methylene chloride with stirring under ice cooling. The mixture was stirred at room temperature for 18 hours. The reaction mixture was washed with water and dried over anhydrous sodium sulfate, followed by removal of the solvent by vacuum evaporation. Then, the residue was purified by silica gel column chromatography to obtain 900 mg of the title compound (yield: 51 %). Property : oily Specific Rotary Power [α] D : +20.2°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3336, ν CO 1748, 1644 Mass Spectrometric Analysis Molecular Formula C₃₅H₆₁N₃O₇ Calculated 635.4509 Found 635.4517 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.03 (3H,s), 1.06 (3H,s), 1.23-1.38 (20H,m), 1.58-1.68 (2H,m), 1.95-2.08 (4H,m), 2.05 (3H,s), 2.11 (3H,s), 2.31 (2H,t,J= 7Hz), 2.42-2.59 (2H,m), 3.35-3.69 (10H,m), 3.83 (1H,d,J=12Hz), 4.02 (1H,d,J=12Hz), 4.88 (1H,s), 5.28-5.40 (2H,m), 6.73 (1H,t,J=6Hz) Example 193 Preparation of 1-Oleoyl-4-{1-oxo-3-[N-(1-oxo-2,4-dihydroxy-3,3-dimethylbutyl)amino]propyl}piperazine An aqueous 1N NaOH solution (2 ml) was added to a solution of 635 mg of 1-Oleoyl-4-{1-oxo-3-[N-(1-oxo-2,4-dihacetoxy-3,3-dimethylbutyl)amino]propyl}piperazine in 5 ml of methanol, and the mixture was stirred at room temperature for 30 minutes. After adding methylene chloride and water to the reaction mixture, the organic layer was separated, which then was washed with brine and dried over anhydrous sodium sulfate, followed by removal of the solvent. The residue was purified by silica gel column chromatography to obtain 482 mg of the title compound (yield: 87 %). Property : oily Specific Rotary Power [α] D : +16.1°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH , ν CO 1646 Mass Spectrometric Analysys Molecular Formula C₃₁H₅₇N₃O₅ Calculated 605.4767 Found 605.4787 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.92 (3H,s), 1.02 (3H,s), 1.22-1.41 (20H,m), 1.57-1.68 (2H,m), 1.92-2.08 (4H,m), 2.33 (2H,t,J=7Hz), 2.54 (2H,brs), 3.12-3.21 (1H,m), 2.59 (2H,t,J=6Hz), 3.41-3.68 (10H,m), 3.99 (1H,s), 5.28-5.40 (2H,m) , 7.30-7.39 (1H,m) Example 194 Preparation of 1-Oleoyl-4-{1-oxo-3-[N-(1-oxo-2,4-diacetoxy 3,3-dimethylbutyl)amino]propyl}tetrahydro-1,4-diazepine 1-Oleoylhomopiperazine (919 mg) and 755 mg of 3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propionic acid were reacted in the same manner as in Example 192 to obtain 930 mg of the title compound (yield: 57 %). Property : oily Specific Rotary Power [α] D : +27.3°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH , ν CO 1748, 1644 Mass Spectrometric Analysis Molecular Formula C₃₆H₆₃N₃O₇ Calculated 649.4665 Found 649.4652 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 1.02 (3H,s), 1.06 (3H,s), 1.23-1.40 (20H,m), 1.56-1.70 (2H,m), 1.78-1.91 (2H,m), 1.92-2.06 (4H,m), 2.04 (3H,s), 2.11 (3H,s), 2.28 (2H,t,J=7Hz), 2.42-2.56 (2H,m), 3.35-3.76 (1H,m), 3,84 (1H,d,J=12Hz), 4.03 (1H,d,J=12Hz), 4.91 (1H,brs), 5.27-5.40 (2H,m), 6.74-6.83 (1H,m) Example 195 Preparation of 1-Oleoyl-4-{1-oxo-3-[N-(1-oxo-2,4-dihydroxy-3,3-dimethylbutyl)amino]propyl}tetrahydro-1,4-diazepine 1-Oleoyl-4-{1-oxo-3-[N-(1-oxo-2,4-diacetoxy-3,3-dimethylbutyl)amino]propyl}tetrahydro-1,4-diazepine (649 mg) was reacted in the same manner as in Example 193 to obtain 515 mg of the title compound. Property : oily Specific Rotary Power [α] D : +14.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH , ν CO 1642 Mass Spectrometric Analysis Molecular Formula C₃₂H₅₉N₃O₅ Calculated 565.4454 Found 565.4440 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.92 (3H,s), 1.02 (3H,s), 1.21-1.39 (20H,m), 1.55-1.68 (2H,m), 1.72-1.88 (2H,m), 1.92-2.08 (4H,m), 2.12-2.62 (6H,m), 3.25-3.85 (10H,m), 3.96 (1H,brs), 5.28-5.40 (2H,m), 7.12-7.22 (1H,m) Example 196 Preparation of 1-Stearoyl-4-[3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanyl]piperazine Sodium carbonate (106 mg) was suspended in a solution of 326 mg of 1-[3-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonylamino)propanyl]piperazine and 303 mg of stearoyl chloride in 20 ml of methylene chloride, and the mixture was allowed to react for 2 hours. After removing insoluble matters by filtration, the solvent was distilled off. The residue was subjected to silica gel column chromatography to obtain 498 mg of the title compound (yield: 84 %). Property : oily Specific Rotary Power [α] D : +28.9°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν NH 3408, ν CO 1656, 1638 Mass Spectrometric Analysis Molecular Formula C₃₄H₆₃N₃O₅ Calculated 593.4767 Found 593.4776 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.19-1.39 (28H,m), 1.56-1.73 (2H,m), 2.33 (2H,t,J=7Hz), 2.56-2.66 (2H,m), 3.28 (1H,d,J= 12Hz), 3.39-3.68 (5H,m), 3.37-3.71 (10H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 7.05-7.14 (1H,m) Example 197 Preparation of 1-Linoleoyl-4-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanyl}piperazine 1-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperazine (489 mg) and linoloyl chloride (421 mg) were reacted in the same manner as in Example 192 to obtain 496 mg of the title compound (yield: 56 %). Property : oily Specific Rotary Power [α] D : +26.7°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν CO 1646 Mass Spectrometric Analysis Molecular Formula C₃₄H₅₉N₃O₅ Calculated 589.4454 Found 589.4431 NMR(δ, CDCl₃): 0.89 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.22-1.42 (14H,m), 1.98-2.09 (2H,m), 2.33 (2H,t,J=7Hz), 2.52-2.63 (2H,m), 2.77 (2H,d,J= 12Hz), 3.28 (1H,d,J=12Hz), 3.36-3.72 (10H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 5.29-5.44 (4H,m), 7.05-7.13 (1H,m) Example 198 Preparation of 1-(8-Heptadecenyl)carbamoyl-4-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperazine Heptadecenyl isocyanate (419 mg) was added to a solution of 489 mg of 1-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperazine (489 mg) in methylene chloride (30 ml) with stirring under ice cooling. Then the solvent was distilled off, and the residue obtained was subjected to silica gel column chromatography to obtain 900 mg of the title compound. Property : oily Specific Rotary Power [α] D : +27.0°(C=1.0, CHCl₃) IR(cm⁻¹, neat): ν CO 1648 Mass Spectrometric Analysis Molecular Formula C₃₄H₆₂N₄O₅ Calculated 606.4820 Found 606.4719 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.90 (3H,s), 1.04 (3H,s), 1.21-1.38 (20H,m), 1.40-1.57 (2H,m), 1.42 (3H,s), 1.46 (3H,s), 2.33 (2H,t,J=7Hz), 1.92-2.04 (4H,m), 2.49-2.65 (2H,m), 3.17-3.73 (14H,m), 4.07 (1H,s), 4.43 (1H,brs), 5.29-5.40 (2H,m), 7.08 (1H,t,J=6Hz) Example 199 1-(2-Methyllauroyl)4-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane)amino]propanoyl}piperazine Molecular formula C₂₉H₅₃N₃O₅ Molecular weight 523.76 Mass Spectrometric Analysis Calculated 523.3985 Found 523.3974 Melting Point (°C) : oil Specific Rotary Power: [α]²⁹ D +30.3°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2928, 2860, 1646 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.11 (3H,d,J=7Hz), 1.15-1.34 (16H,m), 1.42 (3H,s), 1.46 (3H,s), 1.54-1.62 (2H,m), 2.54-2.72 (3H,m), 3.28 (1H,d,J=12Hz), 3.38-3.70 (10H,m), 3.68 (1H,d,J=12Hz), 4.07 (1H,s), 7.15-7.23 (1H,m) Example 200 1-(1-Decylcyclobutanecarbonyl)-4-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperazine Molecular Formula C₃₁H₅₅N₃O₅ Molecular Weight 549.80 Mass Spectrometric Analysis Calculated 549.4141 Found 549.4119 Melting Point (°C) : oil Specific Rotary Power: [α]²⁷ D +29.6°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1642 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.16-1.35 (16H,m), 1.42 (3H,s), 1.46 (3H,s), 1.68-1.98 (6H,m), 2.42-2.60 (4H,m), 3.26-3.68 (10H,m), 3.28 (1H,d,J=12Hz), 3.68 (1H,d,J =12Hz), 4.07 (1H,s), 7.08 (1H,t,J=5Hz) Example 201 1-(2-Benzylundecanoyl)-4-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperazine Molecular Formula C₃₄H₅₅N₃O₅ Molecular Weight 585.83 Mass Spectrometric Analysis Calculated 585.4141 Found 585.4130 Melting Point (°C) : oil Specific Rotary Power: [α]²⁷ D +25.0°(C=1.0, CHCl₃) IR(ν, cm⁻¹): 2928, 2860, 1648 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.94 (3H,s), 1.03 (3H,s), 1.16-1.35 (14H,m), 1.41 (3H,s), 1.45 (3H,s), 1.49-1.78 (2H,m), 2.24-2.58 (3H,m), 2.27-3.93 (14H,m), 4.06 (1H,s), 7.03 (1H,t,J=5Hz), 7.13-7.29 (5H,m) Example 202 1-(1-Benzyldecyl)carbamoyl-4-{3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propanoyl}piperazine To a solution of 553 mg of 2-benzylundecanoic acid and 550 mg of diphenylphosphorylazide in 3 ml of anhydrous toluene was added portion-wise a solution of 223 mg of triethylamine in 3 ml of anhydrous toluene with stirring at room temperature. The reaction mixture was stirred at 80°C for additional 2 hours. After completion of the reaction, the reaction mixture was cooled down to room temperature. Then, a solution of 655 mg of 1-{1-oxo-3-[N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propyl}piperazine in 2 ml of chloroform was added thereto. The resulting mixture was stirred at room temperature for 18 hours. After washing it with a saturated aqueous sodium hydrogen carbonate solution and then with brine, the reaction mixture was dried over anhydrous sodium sulfate, and the solvent was removed by evaporation. The residue was purified by silica gel column chromatography to obtain 599 mg of the title compound (yield: 50 %). Molecular Formula C₃₄H₅₆N₄O₅ Molecular Weight 600.85 Mass Spectrometric Anaylsis Calculated 600.4250 Found 600,4244 Melting Point (°C) : oil Specific Rotary Power: [α]²⁷ D +25.8°(C=1.0, CHCl₃) IR(νneat, cm⁻¹): 2932, 2860, 1636 NMR(δ, CDCl₃): 0.88 (3H,t,J=7Hz), 0.96 (3H,s), 1.04 (3H,s), 1.17-1.40 (16H,m), 1.42 (3H,s), 1.46 (3H,s), 2.47-2.64 (2H,m), 2.72-2.88 (2H,m), 3.15-3.65 (11H,m), 3.28 (1H,d,J=12Hz), 3.68 (1H,d,J= 12Hz), 4.07 (1H,s), 4.08-4.17 (1H,m), 7.18 (1H,t,J=5Hz), 7.12-7.33 (5H,m)

Claims: Compounds represented by general formula (I) below wherein R¹ and R², which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R³ represents a saturated or unsaturated, linear, branched or cyclic, monovalent C₅∼C₂₅-aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula where R⁴ represents a saturated or unsaturated, linear, branched or cyclic, monovalent C₅∼C₂₅-aliphatic hydrocarbon group which may be substituted with an aromatic group, and R⁵ represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrocarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula -X¹-A-Y¹-, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C₂∼C₁₆-aliphatic hydrocarbon group which may be substituted with an aromatic group, a divalent aromatic hydrocarbon group or a divalent aromatic heterocyclic group; one of X¹ and Y¹ represents and the other represents -O-, -S- or in which R⁶ and R⁷ each represent a hydrogen atom or a C₁ to C₆ alkyl group; (b) a group of formula -X²-(CH₂) ℓ -Y²-, where one of X² and Y² represents a group of formula and the other represents -O-, -S- or in which represents a 4∼7-membered, divalent nitrogen-containing non-aromatic heterocyclic group, and R⁶ has the same meaning as defined above, and ℓ is 0, 1 or 2; or (c) a group of formula where m is 2 or 3; n is an integer of from 1 to 4, provided that if Q represents the group of formula -X¹-A-Y¹-, X¹ represents and A is -CH₂-CH₂-, then Y¹ cannot represent -S-. The compounds of Claim 1, wherein R¹ and R², which are the same or different, each represent a hydrogen atom; a C₁ to C₆ alkyl group; a benzyl group which may optionally be substituted with a halogen atom, a C₁ to C₆ alkoxy group, a nitro group or a cyano group; a 5- or 6-membered saturated heterocyclic group containing as hetero atoms N, S or O; or an acyl group; or R¹ and R² combine to form a ylidene group selected from a 1-t-butylethylidene group, a 1-phenylethylidene group, an isopropylidene group, a butylidene group, a cyclopentylidene group, a cyclohexylidene group, a cycloheptylidene group, a benzylidene group, a p-methoxybenzylidene group, a 2,4-dimethoxybenzylidene group, a p-dimethylaminobenzylidene group, and an o-nitrobenzylidene group. The compounds of Claim 1, wherein said saturated or unsaturated, linear, branched or cyclic, monovalent aliphatic hydrocarbon group represented by R³, R⁴ or R⁵ is selected from the class consisting of an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a cycloalkylalkyl group, a cycloalkenylalkyl group, an alkylcycloalkyl group, an alkenylcycloalkyl group, an alkylcycloalkenyl group and alkynylcycloalkynyl group. The compounds of Claim 1, wherein said saturated or unsaturated, linear, branched or cyclic, monovalent aliphatic hydrocarbon group which is substituted with an aromatic group, represented by R³, R⁴ or R⁵, is selected from the class consisting of an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a cycloalkylalkyl group, a cycloalkenylalkyl group, an alkylcycloalkyl group, an alkenylcycloalkyl group, an alkylcycloalkenyl group and alkenylcycloalkenyl group, each being substituted with an aromatic group. The compounds of Claim 1, wherein R³ represents a C₈∼C₂₂-monovalent aliphatic hydrocarbon group. The compounds of Claim 1, wherein R³ represents a C₈~C₂₂-monovalent aliphatic hydrocarbon group substituted with an aromatic group. The compounds of Claim 1, wherein R⁴ represents a C₈∼C₂₂-monovalent aliphatic hydrocarbon group; and R⁵ represents a hydrogen atom or a C₁∼C₁₀-monovalent aliphatic hydrocarbon group. The compounds of Claim 5, wherein R⁴ and R⁵ have 5 to 25 carbon atoms in total. The compounds of Claim 1, wherein R³ represents a group selected from the class consisting of a C₅∼C₂₅-alkyl group which is linear or has a branched chain at the 1-position thereof; a C₁₂∼C₁₈-alkenyl group which is linear or has a branched chain at the 1-position thereof, a C₈∼C₁₈-alkyl-C₄∼C₆-cycloalkyl group; a monosubstituted amino group substituted with a C₈∼C₂₀-alkyl group or a C₈∼C₂₀-alkenyl group; and an amino group which is substituted with an alkyl group or an alkenyl group and has from 8 to 20 carbon atoms in total. The compounds of Claim 1, wherein Q represents a group of formula: -X¹-A-Y¹- herein X¹, Y¹ and A are as defined in Claim 1. The compounds of Claim 10, wherein A represents a group selected from the class consisting of a C₂∼C₁₀-alkylene group which is linear or branched; a C₅∼C₇-cycloalkyl-C₂∼C₅-alkylene group; a C₅∼C₇-cycloalkylene group; a C₄∼C₈-alkenylene group; a C₄∼C₈-alkynylene group; a C₅∼C₇-cycloalkylene-C₁∼C₅-alkylene group; a C₂∼C₅-alkylene group substituted with an aryl group or a heteroaryl group; and a phenylene group. The compounds of Claim 10, wherein one of X¹ and Y¹ represents -NH- or and another represents -O-, -S-, -NH- or The compounds of Claim 1, wherein Q represents a group of formula; -X²-(CH₂) ℓ -Y²-,wherein X², Y² and ℓ are as defined in Claim 1. The compounds of Claim 13, wherein one of X² and Y² represents a group of formula: and the other represents -O-, -S- or The compounds of Claim 1, wherein Q represents a group of formula where m is as defined in Claim 1. The compounds of Claim 1 as pharmaceutically active substances. The compounds of Claim 1 as ACAT inhibitors. A process for preparing the compounds represented by formula (I) of Claim 1, which comprises (a) reacting a compound of formula (II) below wherein R¹¹ and R²¹, which are the same or different, each represent a protected hydroxyl group; and Q and n are as defined in Claim 1; with a compound of formula (III) or (IV) below R³-COZ¹ (III) R⁴-NCO (IV) wherein Z¹ represents a hydrogen atom, a halogen atom, an alkoxy group, or a substituted or unsubstituted phenyloxy group; and R³ and R⁴ are as defined in Claim 1; or (b) reacting a compound of formula (V) below wherein R¹¹, R²¹, n and Z¹ are as defined above; with a compound of formula (VI) below H-Q-CO-R³ (VI) wherein R³ and Q are as defined above; or (c) eliminating said protective group for said hydroxyl groups in resulting compound of formula (I-1) below wherein R¹¹, R²¹, n and R³ are as defined above. Medicament containing at least one compound represented by formula (I) of Claim 1. Pharmaceutical composition comprising a therapeutically effective amount of at least one compound represented by formula (I) of Claim 1 and a pharmaceutical adjuvant. ACAT inhibiting agent containing at least one compound represented by formula (I) of Claim 1 as an active ingredient. Use of the compounds represented by formula (I) of Claim 1 for preparing medicaments for treating or preventing hyperlipemia, arteriosclerosis, angina pectoris, myocardial infarction or thrombosis.

Inventors: IKAWA HIROSHI, KOBAYASHI NOBUO, KUSUNOKI JUN, MATSUMOTO HAJIME, IKAWA, HIROSHI, KOBAYASHI, NOBUO, KUSUNOKI, JUN, MATSUMOTO, HAJIME
Applicants: FUJIREBIO KK, FUJIREBIO INC.
Application year: 1990
Main classification: C07C235
IPC codes: C07C327, C07D405, C07C235, C07D407, C07C323, C07D295, C07C237, C07D319