Acaricidal composition

Abstract: An acaricidal composition comprises, as active ingredient, one or more compounds selected from methyl cinnamate, ethyl cinnamate, n-propyl cinnamate, isopropyl cinnamate, n-butyl cinnamate, isobutyl cinnamate, isoamyl cinnamate, n-hexyl cinnamate, allyl cinnamate, cinnamyl acetate, cinnamyl propionate, cinnamyl n-butyrate, cinnamyl isobutyrate, p-cresyl acetate, p-cresyl butyrate, p-cresyl isobutyrate, p-methylbenzyl propionate, β-phenoxyethyl alcohol, phenoxyethyl acetate, phenoxyethyl propionate, phenoxyethyl n-butyrate, phenoxyethyl isobutyrate, methyl phenylacetate, ethyl phenylacetate, dibenzyl ether, heliotropin, methyl diphenyl ether and 2-methyl-1-(methylbicyclo[2.2.1]­ hept-5-en-2-yl)-1-penten-3-ol.

Description: This invention relates to the use of one or more compounds as an acaricidal agent in a composition which is free from harmful effects on human beings and is very effective for exterminating house dust acari. House dust acari inhabit, and propogate mainly in, highly moist places, for example, on the surface of floors, under or within floor coverings such as tatami or carpet, or within bedclothes. Recently, Dermatophagoides including Dermatophagoides pteronyssinus and Dermatophagoides farinae , which constitute 90% of house dust acari, have become a serious problem since they are important allergens causing bronchial asthma, allergic rhinitis and atopic dermatitis. The most effective method for exterminating these acari is to ventilate and dry the house well. However, the recent increase in the number of houses having a closed structure and changes in life style make it more and more difficult to ventilate a room sufficiently. Under these circumstances, the damage caused by acari has become more and more serious. In order to exterminate these acari, various acaricides (for example, organophosphorus compounds such as fenitrothion, fenthion, dichlorvos, diazinon; carbamate compounds such as propoxur, carbaryl; pyrethroid compounds such as resmethrin, phenothrin, permethrin) have been applied in the form of aerosol, fumigant, insecticidal sheet or impregnating agent for, eg, carpets. Furthermore, it was recently proposed to use compounds other than those cited above for exterminating acari. For example, JP-A-61-57501 discloses using a combination of acaricidal compounds such as benzyl benzoate, benzyl salicylate or dibutyl phthalate with a powdery cleanser, and indicates that the acaricidal effect of benzyl benzoate has been physiologically particularly well studied. (The term "JP-A" as used herein means an "unexamined published Japanese patent application".) JP-A-61-91103 discloses an acaricide which comprises benzyl benzoate and an aliphatic hydrocarbon as the major components. Further, JP-A-61-87603 discloses benzyl salicylate and phenethyl benzoate, while JP-A-62-33106 discloses phenyl salicylate, phenyl benzoate, diphenylamine, methyl β-naphthyl ketone and coumarin each as an active ingredient for an acaricide. Furthermore, JP-A-64-19004 discloses an acaricide comprising benzaldehyde or perillaldehyde, l-carvone or d-carvone, methyl salicylate or ethyl salicylate, or methyl benzoate or ethyl benzoate as an active ingredient. Regarding natural substances, furthermore, JP-A-63-104905 discloses that terpene compounds are available as acari-prevention agents. Furthermore, it is known that other vegetable essential oils (for example, bitter almond oil, wintergreen oil) show an acaricidal effect (F. Watanabe et al., Shoyakugaku Zasshi , 43 [2], 163-168 (1989)). However, typical known acaricidal compounds (particularly organophosphorus compounds and carbamate compounds) generally show a high toxicity and exert undesirable effects on the human body. Therefore, it is undesirable to use these compounds in confined conditions or around houses. These compounds are further disadvantageous in that their effects on Dermatophagoides causing allergic diseases are limited. On the other hand, pyrethroid compounds are expensive and show only limited effects on house dust acari, though they are less toxic in general. Other acaricidal compounds are also disadvantageous in their limited effects on Dermatophagoides . FR-A-2096963 describes certain cinnamate esters merely as stabilizers for organophosphoric insecticides. As a result of the incorporation of such esters into organophosphoric insecticides the decomposition ratio with lapse of time of such insecticides is reduced. Chemical Abstracts, (1978), vol. 88, No. 3, abstract No. 17260Z discloses that methyl cinnamate is effective as an insecticide against stored grain insects, mentioning specifically Tribolium castaneum, Sitophilus oryzae, Stagobium paniceum , and Bruchus chinensis which belong to Tenebrionidae, Rhynchophoridae, Anobiidae , and Bruchidae . US 3259648 and EP-A-0235722 disclose compositions comprising cyclohexylmethyl and propargyl esters of cinnamic acid respectively. US 3259648, however, only demonstrates an insecticidal effect against cockroaches, and EP 235722 does not specifically show any acaricidal effect. Accordingly, it has been urgently required to develop an acaricide which is very safe with respect to effects on the human body, can be easily used anywhere in the house, and yet exerts a powerful effect in exterminating a number of house dust acari, including Dermatophagoides , which cause allergic diseases. We have found that the following compounds, which have been used as perfumes in foods and cosmetics for a long time and have thus been proved to be harmless to human beings, are highly effective in the extermination of house dust acari. According to the present invention there is provided the use of one or more compounds selected from methyl cinnamate, ethyl cinnamate, n-propyl cinnamate, isopropyl cinnamate, n-butyl cinnamate, isobutyl cinnamate, isoamyl cinnamate, n-hexyl cinnamate, allyl cinnamate, cinnamyl acetate, cinnamyl propionate, cinnamyl n-butyrate and cinnamyl isobutyrate as an acaricidal agent in a composition for the control of house dust acari. The acari to be exterminated with the composition of the present invention include not only house dust acari inhabiting and propagating indoors, for example, Pyroglyphidae such as Dermatophagoides farinae and Dermatophagoides pteronyssius ; Acaridae such as Typophagus putrescentiae and Aleuroglyphus ovatus ; Glycyphagidae such as Glycyphagus privatus and Glycyphagus domesticus ; and Chyletidae such as Chyletus malaccensis and Chyletus fortis ; but animal-parasitic acari, for example, Marcronyssidae such as Ornithonyssus bacoti and Orrnithonyssus sylviarum . The compounds used in the present invention may be combined with one or more substances selected from p-cresyl acetate, p-cresyl butyrate, p-cresyl isobutyrate, p-methylbenzyl propionate, β-phenoxyethyl alcohol, phenoxyethyl acetate, phenoxyethyl propionate, phenoxyethyl n-butyrate, phenoxyethyl isobutyrate, methyl phenylacetate, ethyl phenylacetate, dibenzyl ether, heliotropin, methyl diphenyl ether and 2-methyl-1-(methylbicyclo[2.2.1]hept-5-en-2-yl)-1-penten-3-ol. In general, however, the composition may be formulated into an oil preparation, emulsifiable concentrate, wettable powder, spray, aerosol, fumigant, coating, detergent, dust, granules or capsules by supporting on a solid or liquid carrier and optionally adding various additives, for example, film-forming agent, emulsifier, sticking agent, dispersant, wetting agent, stabilizer, propellant and volatility-controller, if required. Examples of the solid carrier to be used herein include mineral powders such as silicic acid, kaolin, activated carbon, bentonite, diatomaceous earth, talc and calcium carbonate; vegetable powders such as wheat flour and starch; and synthetic polymer powder such as polyvinyl chloride powder. Examples of the liquid carrier include water; aliphatic hydrocarbons such as hexane, kerosene and coal oil; aromatic hydrocarbons such as benzene, toluene and xylene; halogenated hydrocarbons such as dichloroethane and carbon tetrachloride; alcohols such as ethanol, isopropyl alcohol and ethylene glycol; ketones such as acetone, methyl ethyl ketone and cyclohexanone; ethers such as tetrahydrofuran, dimethoxyethane and diethyl ether; esters such as ethyl acetate; nitriles such as acetonitrile; acid amides such as dimethylformamide; and vegetable oils such as soybean oil and cotton seed oil. Examples of the film-forming agent include cellulose derivatives, vinyl resins, alkyd resins, urea resins, epoxy resins, polyester resins, urethane resins, silicone resins, acrylic resins, chlorinated rubbers and polyvinyl alcohol. Examples of the emulsifier, sticking agent and dispersant include surfactants such as soaps, polyoxyethylene alkylaryl ethers, polyoxyethylene fatty acid esters, fatty acid glycerols, sorbitan fatty acid esters, higher alcohol sulfates and alkylarylsulfonic acid salts. Examples of the propellant include liquefied petroleum gas, Freon gas and dimethyl ether. Examples of the volatility-controller include tricylodecane and cyclododecane. Furthermore, the acaricidal agent may be used together with sublimating insecticides such as paradichlorobenzene, naphthalene or camphor so as to give a sublimating solid preparation. Moreover, the composition used in the present invention may contain, for example, various conventional insecticides, acaricides, synergists, harmful insect repellents, rodent repellents, bactericides, fungicides, perfumes or colorants used for exterminating harmful insects, such as fenitrothion, propoxur or resmethrin. The content of the above-mentioned acaricidal agent in the composition used in the present invention may vary depending on the formulation, application means and the place to be applied. It is generally preferable that the total content of the acaricidal agent ranges from 0.1 to 50% by weight (in the case of wettable powder or emulsifiable concentrate) and from 0.1 to 30% by weight (in the case of oil preparation or aerosol), respectively. The composition used in the present invention thus prepared may be applied to, for example, floors, tatami , carpets, bedclothes, sofas, pillows or closets by depositing, spraying, coating, transpiring or placement. Alternatively, it may be used as a detergent for human or pet animals. The dose is preferably approximately 80 mg or more per m 2 of the area to be treated or approximately 8 mg or more per m 3 of the space to be treated, in terms of the total amount of the acaricidal agent. In addition to the above formulations, the composition used in the present invention may be formulated into film, sheet or constructional material having an acaricidal activity by supporting the acaricidal agent on an appropriate substrate. Examples of the substrate to be used herein include sheets of synthetic resins such as polyethylene, polypropylene, nylon, polyvinyl chloride or polyesters; animal or vegetable fibrous materials or inorganic fibrous materials such as paper, cloth, non-woven cloth and leather; mixed sheets of the above-mentioned synthetic resins and animal, vegetable or inorganic fibers; mixed fabrics or non-woven fabrics; foils or films of metals such as aluminum, stainless steel or zinc; laminates of the above-mentioned sheets; and various natural wooden materials and plastics molded articles employed for constructional purposes. The acaricidal agent of the composition used in the present invention is supported on these substrates by coating, impregnating, depositing or cofabricating to give an acaricidal material. The amount of the acaricidal agent in the substrate is not particularly restricted but may be optionally selected. In the case of impregnation, it is preferable to use the acaricidal agent in the saturation amount. The acaricidal material thus obtained may be preferably used, for example, in the following manner. A polymer sheet (for example, polypropylene) impregnated with the acaricidal agent used in the present invention is placed under tatami , carpets or sofas. In this case, it is preferable to use the acaricidal agent at a ratio of from approximately 0.5 to 20 g per unit area. The impregnation of the polymer with the acaricidal agent makes the sustained release of the acaricidal agent possible, which brings about a sustained acaricidal effect. The effects of the acaricidal agents used in the present invention were examined by using Dermatophagoides pteronyssinus , which is one of Dermatophagoides and is generally less sensitive to chemicals, by the following procedure. Namely, a filter paper (5 mm × 5 mm) is impregnated with each test compound in such a manner as to give the definite concentration. A liquid compound is used as such while a solid one is dissolved in acetone. In accordance with a method reported by Watanabe et al., Shoyakugaku Zasshi , 43 [2], 163-168 (1989), the filter sheet is introduced into a cylindrical container (approximately 20 cc) containing 50 to 80 head of Dermatophagoides pteronyssinus together with a bait. The container is then sealed with a Teflon stopper and allowed to stand in an incubator at 25°C. After 24 hours and 48 hours, the life or death of the acari is examined under a stereoscopic microscope or a loupe (× 25) and evaluated. The procedure is repeated thrice and the lethality is calculated according to the following equation. Table 1 shows average values. Lethality (%) = (X - Y)/X × 100 X: number of living acari in untreated plot; and Y: number of living acari in treated plot. In Table 1, a mixture of Test Compounds is expresed by the Compound Number of each component. For comparison, permethrin and benzyl salicylate, which are conventional acaricides, were also evaluated in the same manner. The results are shown in Table 1. As Table 1 clearly shows, the acaricidal agents used in the composition of the present invention were superior to permethrin and benzyl salicylate for exterminating Dermatophagoides pteronyssinus . To further illustrate the present invention, and not by way of limitation, the following Examples will be given. EXAMPLE 1 Oil Preparation: (parts by weight) Ethyl cinnamate 2 Isopropyl alcohol 98 Total 100 The above components were mixed under stirring to give a homogeneous oil preparation. EXAMPLE 2 Emulsifiable Concentrate: (parts by weight) Cinnamyl acetate 20 Sorbitan monostearate 10 Xylene 70 Total 100 The above components were mixed under stirring to give a homogeneous emulsion. EXAMPLE 3 Sheet material: (parts by weight) Ethyl cinnamate 10 Dibenzyl ether 10 Ethyl cellulose 10 Ethanol 70 Total 100 The above components were mixed under stirring, and a polyethylene pulp non-woven fabric was impregnated therewith in such a manner as to give a total amount of ethyl cinnamate and dibenzyl ether of 1 g/m 2 . Thus a sheet material was obtained. The composition used in the present invention exhibits an excellent effect of extermination house dust acari. Further, it is highly safe to human body and can be easily applied in the house, which makes it extremely advantageous.

Claims: Use of one or more compounds selected from methyl cinnamate, ethyl cinnamate, n-propyl cinnamate, isopropyl cinnamate, n-butyl cinnamate, isobutyl cinnamate, isoamyl cinnamate, n-hexyl cinnamate, allyl cinnamate, cinnamyl acetate, cinnamyl propionate, cinnamyl n-butyrate and cinnamyl isobutyrate as an acaricidal agent in a composition for the control of house dust acari. Use as claimed in Claim 1, of one or more of said compounds in combination with one or more substances selected from p-cresyl acetate, p-cresyl butyrate, p-cresyl isobutyrate, p-methylbenzyl propionate, β-phenoxyethyl alcohol, phenoxyethyl acetate, phenoxyethyl propionate, phenoxyethyl n-butyrate, phenoxyethyl isobutyrate, methyl phenylacetate, ethyl phenylacetate, dibenzyl ether, heliotropin, methyl diphenyl ether and 2-methyl-1-(methylbicyclo[2.2.1]hept-5-en-2-yl)-1-penten-3-ol. Use as claimed in Claim 1 or 2 of one or more of said compounds wherein said composition contains a solid or liquid carrier. Use as claimed in Claim 3 of one or more of said compounds, wherein the acaricidal agent is present in an amount of from 0.1 to 50% by weight. Use as claimed in Claim 4 of one or more of said compounds, wherein said composition is in the form of a wettable powder or an emulsifiable concentrate. Use as claimed in Claim 3 of one or more of said compounds, wherein the acaricidal agent is present in an amount of from 0.1 to 30% by weight. Use as claimed in Claim 6 of one or more of said compounds, wherein said composition is in the form of an oil preparation or an aerosol. A method of exterminating house dust acari, which comprises applying one or more compounds selected from methyl cinnamate, ethyl cinnamate, n-propyl cinnamate, isopropyl cinnamate, n-butyl cinnamate, isobutyl cinnamate, isoamyl cinnamate, n-hexyl cinnamate, allyl cinnamate, cinnamyl acetate, cinnamyl propionate, cinnamyl n-butyrate and cinnamyl isobutyrate to a location inhabited by house dust acari. A method as claimed in Claim 8, in which one or more of said compounds is applied in combination with one or more substances selected from p-cresyl acetate, p-cresyl butyrate, p-cresyl isobutyrate, p-methylbenzyl propionate, β-phenoxyethyl alcohol, phenoxyethyl acetate, phenoxyethyl propionate, phenoxyethyl n-butyrate, phenoxyethyl isobutyrate, methyl phenylacetate, ethyl phenylacetate, dibenzyl ether, heliotropin, methyl diphenyl ether and 2-methyl-1-(methylbicyclo[2.2.1]hept-5-en-2-yl)-1-penten-3-ol. A method as claimed in Claim 8 or 9, wherein said house dust acari are Dermatophagoides .

Inventors: HATA HAMAKO, SATO TOSHIYA, HATA, HAMAKO, SATO, TOSHIYA, HATA, HAMAKO, C/O TAKASAGO INT. CORP., SATO, TOSHIYA, C/O TAKASAGO INT. CORP.
Applicants: TAKASAGO PERFUMERY CO LTD, TAKASAGO INTERNATIONAL CORPORATION
Application year: 1990
Main classification: A01N37
IPC codes: A01N39, A01N37, A01N43, A01N31