Retroviral protease inhibiting compounds

Abstract: A retroviral protease inhibiting compound of the formula A - X - B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized imino, (4) functionalized alkyl, (5) functionalized acyl, (6) functionalized heterocyclic or (7) functionalized (heterocyclic)alkyl; and B is (1) substituted carbonyl independently defined as herein, (2) substituted amino independently defined as herein, (3) functionalized imino independently defined as herein, (4) functionalized alkyl independently defined as herein, (5) functionalized acyl independently defined as herein, (6) functionalized heterocyclic independently defined as herein or (7) functionalized (heterocyclic)alkyl independently defined as herein.

Description: Technical Field This invention was made with Government support under contract number AI27220-01 awarded by the National Institute of Allergy and Infectious Diseases. The Government has certain rights in this invention. The present invention relates to novel compounds and a composition for inhibiting retroviral proteases and in particular for inhibiting human immunodeficiency virus (HIV) protease, a composition for treating a retroviral infection and in particular an HIV infection, processes for making such compounds and synthetic intermediates employed in these processes. Background Art Retroviruses are those viruses which utilize a ribonucleic acid (RNA) intermediate and a RNA-dependent deoxyribonucleic acid (DNA) polymerase, reverse transcriptase, during their life cycle. Retroviruses include, but are not limited to, the RNA viruses of the Retroviridae family, and also the DNA viruses of the Hepadnavirus and Caulimovirus families. Retroviruses cause a variety of disease states in man, animals and plants. Some of the more important retroviruses from a pathological standpoint include human immunodeficiency viruses (HIV-1 and HIV-2), which cause acquired immune deficiency syndrome (AIDS) in man, hepatitis B virus, which causes hepatitis and hepatic carcinomas in man, human T-cell lymphotrophic viruses I, II, IV and V, which cause human acute cell leukemia, and bovine and feline leukemia viruses which cause leukemia in domestic animals. Proteases are enzymes which cleave proteins at specific peptide bonds. Many biological functions are controlled or mediated by proteases and their complementary protease inhibitors. For example, the protease renin cleaves the peptide angiotensinogen to produce the peptide angiotensin I. Angiotensin I is further cleaved by the protease angiotensin converting enzyme (ACE) to form the hypotensive peptide angiotensin II. Inhibitors of renin and ACE are known to reduce high blood pressure in vivo . An inhibitor of a retroviral protease should provide a therapeutic agent for diseases caused by the retrovirus. The genomes of retroviruses encode a protease that is responsible for the proteolytic processing of one or more polyprotein precursors such as the pol and gag gene products. See Wellink, Arch. Virol. 98 1 (1988). Retroviral proteases most commonly process the gag precursor into core proteins, and also process the pol precursor into reverse transciptase and retroviral protease. In addition, retroviral proteases are sequence specific. See Pearl, Nature 328 482 (1987). The correct processing of the precursor polyproteins by the retroviral protease is necessary for the assembly of infectious virions. It has been shown that in vitro mutagenesis that produces protease-defective virus leads to the production of immature core forms which lack infectivity. See Crawford, J. Virol. 53 899 (1985); Katoh, et al., Virology 145 280 (1985). Therefore, retroviral protease inhibition provides an attractive target for antiviral therapy. See Mitsuya, Nature 325 775 (1987). Current treatments for viral diseases usually involve administration of compounds that inhibit viral DNA synthesis. Current treatments for AIDS (Dagani, Chem. Eng. News, November 23, 1987 pp. 41-49) involve administration of compounds such as 2',3'-dideoxycytidine, trisodium phosphonoformate, ammonium 21-tungsto-9-antimoniate, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, 3'-azido-3'-deoxythymidine, and adriamycin that inhibit viral DNA synthesis; compounds such as AL-721 and polymannoacetate which may prevent HIV from penetrating the host cell; and compounds which treat the opportunistic infections caused by the immunosuppression resulting from HIV infection. None of the current AIDS treatments have proven to be totally effective in treating and/or reversing the disease. In addition, many of the compounds currently used to treat AIDS cause adverse side effects including low platelet count, renal toxicity and bone marrow cytopenia. Inhibitors of HIV protease are disclosed by Moore, Biochem. Biophys. Res. Commun., 159 420 (1989); Billich, J. Biol. Chem., 263 1790S (1988); Richards, FEBS Lett., 247 113 (1989); Miller, Science 246 1149 (1989); Meek, Nature 343 90 (1990); McQuade, Science 247 454 (1990); Sigal, et al., European Patent Application No. EP0337714, published October 18, 1989; Kempf, et al., PCT Patent Application No. WO89/10752, published November 16, 1989; Molling, et al., European Patent Application No. EP354522, published February 14, 1990; Sigal, et al., European Patent Application No. EP357332, published March 7, 1990; Handa, et al., European Patent Application No. EP346847, published December 20, 1989; Desolms, et al, European Patent Application No. EP356223, published February 28, 1990; Schirlin, et al., European Patent Application No. EP362002, published April 4, 1990; Dreyer, et al., PCT Patent Application No. WO90/00399, published January 25, 1990; and Hanko, et al., European Patent Application No. EP361341, published April 4, 1990. U.S. Patent No. 4,652,552 discloses methyl ketone derivatives of tetrapeptides as inhibitors of viral proteases. U.S. Patent No. 4,644,055 discloses halomethylketone derivatives of peptides as inhibitors of viral proteases. None of the references mentioned above disclose or suggest the invention claimed herein. Disclosure of the Invention In accordance with the present invention, there are retroviral protease inhibiting compounds of the formula: wherein X is -CH(OR 201 )-, -CH(OR 201 )CH(OR 202 )-, -C(O)-C(R)(R')- or -CH(R'')-C(R)(R') wherein R 201 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl and R 10 O-R 11 O-alkyl wherein R 10 and R 11 are independently selected from loweralkyl and benzyl; R 202 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl thioalkoxyalkyl, benzylthioalkyl and R 12 O-R 13 O-alkyl wherein R 12 and R 13 are independently selected from loweralkyl and benzyl; R is halogen; R' is halogen; R'' is -NH 2 , -NH(loweralkyl) or -OR 206 wherein R 206 is hydrogen, loweralkyl or alkoxyalkyl or benzyloxyalkyl; R 3 at each occurrence is independently selected from (aryl)alkyl or (heterocyclic)alkyl; R 9 at each occurrence is independently selected from hydrogen and loweralkyl; and G is R 17 -R 800 -C(T)-E-CH(R 3' )-C(T)- wherein R 17 at each occurrence is independently selected from (aryl)alkyl and(heterocyclic)alkyl, R 800 at each occurrence is independently selected from O, S, -NH- and -N(loweralkyl)-, T is independently selected at each occurrence from O and S, E at each occurrence is independently selected from O, S, -NH- and -N(loweralkyl)- and R 3' at each occurrence is independently selected from loweralkyl; or a salt or ester thereof wherein the eater is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. In particular, there are retroviral protease inhibiting compounds of the above formula wherein X is -CH(OR 201 )CH(OR 202 )- and R 201 and R 202 are as defined above. The chiral centers of the compounds of the invention may be racemic or asymmetric. Racemic mixtures, mixtures of diastereomers, as well as single diastereomers of the compounds of the invention are included in the present invention. The terms "S" and "R" configuration are as defined by the IUPAC 1974 Recommendations for Section E, Fundamental Stereochemistry, Pure Appl. Chem. (1976) 45, 13 - 30. The terms "Ala", "Asn", "Gly", "Ile", "Leu", "Lys", "Phe", "Pro", "Ser", and "Val" as used herein refer to alanine, asparagine, glycine, isoleucine, leucine, lysine, phenylalanine, proline, serine and valine, respectively. In general, the amino acid abbreviations used herein follow the IUPAC-IUB Joint Commission on Biochemical Nomenclature for amino acids and peptides (Eur. J. Biochem. 1984, 158 , 9-31). The term "N-protecting group" or "N-protected" as used herein refers to those groups intended to protect nitrogen atoms against undesirable reactions during synthetic procedures or to prevent the attack of exopeptidases on the final compounds or to increase the solubility of the final compounds and includes but is not limited to acyl, acetyl, pivaloyl, t-butylacetyl, t-butyloxycarbonyl (Boc), benzyloxycarbonyl (Cbz) or benzoyl groups or an L- or D-aminoacyl residue, which may itself be N-protected similarly. The term "loweralkyl" as used herein refers to straight or branched chain alkyl radicals containing from 1 to 6 carbon atoms including, but not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, n-pentyl, 1-methylbutyl, 2,2-dimethylbutyl, 2-methylpentyl, 2,2-dimethylpropyl, n-hexyl and the like. The term "aryl" as used herein refers to a monocyclic or bicyclic carbocyclic ring system having one or more aromatic rings including, but not limited to, phenyl, naphthyl, tetrahydronaphthyl, indanyl and the like. Aryl groups can be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide. In addition, substituted aryl groups include tetrafluorophenyl and pentafluorophenyl. The term "arylalkyl" as used herein refers to an aryl group appended to a loweralkyl radical including, but not limited to, benzyl, 4-hydroxybenzyl, 1-naphthylmethyl and the like. The term "alkylamino" as used herein refers to a loweralkyl radical appended to an NH radical. The term "cycloalkyl" as used herein refers to an aliphatic ring having 3 to 7 carbon atoms including, but not limited to, cyclopropyl, cyclopentyl, cyclohexyl and the like. Cycloalkyl groups can be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide. The terms "alkoxy" and "thioalkoxy" as used herein refer to R 18 O- and R 18 S-, respectively, wherein R 18 is a loweralkyl group. The term "alkoxyalkyl" as used herein refers to an alkoxy group appended to a loweralkyl radical. The term "thioalkoxyalkyl" as used herein refers to a thioalkoxy group appended to a loweralkyl radical. The term "alkoxyalkoxyalkyl" as used herein refers to an alkoxy group appended to an alkoxy group which is in turn appended to a loweralkyl radical including, but not limited to, methoxyethoxymethyl and the like. The term "dialkylamino" as used herein refers to -NR 20 R 21 wherein R 20 and R 21 are independently selected from loweralkyl groups. The term "benzyloxyalkyl" as used herein refers to a benzyloxy group appended to a loweralkyl radical. The term "benzylthioalkyl" as used herein refers to a benzylthio group appended to a loweralkyl radical. The term "((alkoxy)alkoxy)alkyl" as used herein refers to an alkoxy group appended to an alkoxy group which is appended to a loweralkyl radical. The term "polyalkoxy" as used herein refers to -OR 45 wherein R 45 is a straight or branched chain containing 1-5, C n' -O-C n'' linkages wherein n' and n'' are independently selected from 1 to 3, including but not limited to methoxyethoxymethoxy, methoxymethoxy and the like. The term "halo" or "halogen" as used herein refers to -Cl, -Br, -I or -F. The term "haloalkyl" as used herein refers to a loweralkyl radical in which one or more of the hydrogen atoms are replaced by halogen including, but not limited to, chloromethyl, trifluoromethyl, 1-chloro-2-fluoroethyl and the like. The term "heterocyclic ring" or "heterocyclic" as used herein refers to any 3- or 4-membered ring containing a heteroatom selected from oxygen, nitrogen and sulfur; or a 5- or 6-membered ring containing one, two or three nitrogen atoms; one nitrogen and one sulfur atom; or one nitrogen and one oxygen atom. The 5-membered ring has 0-2 double bonds and the 6-membered ring has 0-3 double bonds. The nitrogen and sulfur heteroatoms can be optionally oxidized. The nitrogen heteroatoms can be optionally quaternized. The term "heterocyclic" also includes bicyclic groups in which any of the above heterocyclic rings is fused to a benzene ring or or a cyclohexane ring or another heterocyclic ring. Heterocyclics include: pyrrolyl, pyrrolinyl, pyrrolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, pyridyl, piperidinyl, pyrazinyl, piperazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolidinyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, furyl, thienyl and benzothienyl. Heterocyclics also include: Heterocyclics can be unsubstituted or monosubstituted or disubstituted with substituents independently selected from hydroxy, halo, oxo (=O), alkylimino (R*N= wherein R* is a loweralkyl group), amino, alkylamino, dialkylamino, alkoxy, benzyloxy, polyalkoxy, haloalkyl, cycloalkyl, -COOH, -SO 3 H and loweralkyl. In addition, nitrogen containing heterocycles can be N-protected. The term "(heterocyclic)alkyl" as used herein refers to a heterocyclic group appended to a loweralkyl radical, including but not limited to imidazolylmethyl, thiazolylmethyl, pyridylmethyl and morpholinylmethyl. In the compounds of the present invention, the X and the -CH(R 3 )N(G)(R 9 ) components may have asymmetric centers and occur as racemates, racemic mixtures, mixtures of diastereomers and as individual diastereomers, with all isomeric forms being included in the invention. When any variable occurs more than one time in any constituent or in a compound of Formula I, its definition on each occurrence is independent of its definition at every other occurrence. Also, combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. Representative compounds of the invention of the formula A-X-B, wherein A and B are each independently defined as -CH(R 3 )N(G)(R 9 ), include those represented in Table 2. (In the table "Ph" represents phenyl and p-C7H7 represents 4-methylphenyl). The compounds of the invention can be prepared as shown in Schemes 1-13. The syntheses of segment (II) are described in the Examples. The process shown in Scheme 1 discloses the condensation of carboxylic G - OH to segment (II) in the presence of a coupling reagent to give (VI). Coupling reagents known in the art which can be used include, but are not limited to, dicyclohexylcarbodiimide (DCC), 3-ethyl-3'-(dimethylamino)propylcarbodiimide (EDC), bis(2-oxo-3-oxazolidinyl)-phosphinic chloride (BOP-Cl), dipenylphosphoryl azide (DPPA) and the like. In addition to the use of the carboxylic acids shown in the scheme, acid halide and other activated ester derivatives of the carboxylic acid are useful for the coupling reactions with (II). Acid halide derivatives include the acid chloride. Activated ester derivatives include activated esters commonly used by those skilled in the art for activating carboxylic acid groups for coupling with an amine to form an amide bond including, but not limited to, formic and acetic acid derived anhydrides, anhydrides derived from alkoxycarbonyl halides such as isobutyloxycarbonylchloride and the like, N-hydroxysuccinimide derived esters, N-hydroxyphthalimide derived esters, N-hydroxybenzotriazole derived esters, N-hydroxy-5-norbornene-2,3-dicarboxamide derived esters, 2,4,5-trichlorophenol derived esters and the like. The compounds of the invention having a fluorinated X group can be prepared as shown in the synthetic Scheme 2. The process shown in the synthetic scheme shows the preparation of the key intermediate XV. The synthesis starts with a protected amino alcohol X, which was oxidized by Swern oxidation to the corresponding aldehyde XI. Reformatsky reaction with ethyl bromodifluoroacetate provided XII. Deprotection of XII, followed by treatment with phosgene gave XIII which upon hydrolysis of the ester and treatment with an organometallic such as an alkyllithium or alkyl Grignard provided compound XIV. Oxime formation from XIV and hydrogenation, followed by basic hydrolysis of the oxazolidinone ring gave the key intermediate XV. Coupling of protected amino acid, or amino acid derivatives or peptidyl fragments J to the intermediate XV provides the compounds of the invention XVI. Oxidation of XVI provided the compounds of the invention XVII. Compounds of the invention wherein X is -CH(OR 201 )- can be prepared as shown in Scheme 3. The process shown in Scheme 3 discloses the reduction and subsequent addition of vinylmagnesium bromide to protected aminoester XVIII. The resulting allylic alcohol XIX is mesylated to provide XX, which is treated with a Grignard reagent and catalytic CuCN to provide olefin XXI. Epoxidation of XXI leads to XXII which is regioselectively opened with azide anion to provide XXIII. Reduction of the azide gives XXIV and deprotection provides XXV, both of which can be coupled according to Scheme 1 to provide compounds of the invention. Compounds of the invention wherein X is -CH(OR 201 )-CH(OR 202 )- can be prepared as shown in Scheme 4. The process shown in Scheme 4 discloses the oxidation of XXVI to protected aminoaldehyde XXVII. Reductive dimerization of XXVII provides the doubly protected diaminodiol XXVIII, which is deprotected to give diaminodiol XXIX. Coupling of XXIX according to Scheme 1 provides compounds of the invention. Compounds of the invention of the the type XXXII, in which R 3 is as defined above, may be prepared as outlined in Scheme 5. Thus the known aziridine XXX (Y. L. Merrer, et al Heterocycles , 1987, 25, 541-548) is acylated (e.g. with G=Cbz-valine) or sulfonated (e.g. with G=p-toluene sulfonic acid) to provide compounds of the formula XXXI. These compounds are in turn treated with various nucleophiles, such as thiols, alcohols, amines, or organometallic reagents, which serve to open the aziridine ring. The acetonide can be removed by acid hydrolysis. When G is a sulfonic acid residue, e.g. p-toluenesulfonyl, this group may be removed reductively, for example, with sodium in liquid ammonia or with sodium napthalenide, to provide compounds of the formula XXXII wherein G is hydrogen. These compounds, in turn, can be N-acylated with protected amino acids, e.g. Cbz-valine, to provide additional compounds of the formula XXXII. As outlined in Scheme 6, pro-drug compounds of the invention of the formula XXXVI and XXXVII may be prepared by acylation of XXXIII with bromoacetyl bromide, followed by displacement of the bromide with various amine nucleophiles. R 800 and R 801 may be selected independently from hyrodgen and alkyl, or may consititute a heterocyclic ring incorporating the nitrogen to which the are appended, e.g., rings such as morpholine, piperidine, and piperazine. Pro-drug compounds of the invention of formula XL and XLI may be prepared by acylation of XXXIII with (chloromethyl)benzoyl chloride, followed by displacement of the benzylic chloride group with various amine nucleophiles. As outlined in Scheme 7, pro-drug compounds of the invention of formula XLV and XLVI, and L and LI, are prepared in analogous fashion from compounds XLII and XLVII. As outlined in Scheme 8, the compound of the formula LXIII may be oxidized with the Swern reagent in a solvent like THF, and without isolation, treated with an organometallic reagent, such as a Grignard reagent, to provide compounds of the formula LXVII. These compounds, may in turn, be converted to the carbamates LXVIII with an isocyante, wherein R 804 is hydrogen or benzyl or subsituted benzyl. These carbamates may then be treated with a strong base such as potassium t-butoxide or sodium hydride in a suitable solvent such as THF, and the resulting cyclic carbamates treated with hydrogen over a palladium catalyst to provide compounds of the formula LXIX. The following examples will serve to further illustrate preparation of the novel compounds of the invention. The examples which produce compounds of the invention are those listed in Table 2. Example 1 A. 3-Hydroxy-5-phenyl-1-pentene. Vinylmagnesium Bromide (120 mmol, 1 M) in ether was added to 80 ml of dry tetrahydrofuran and cooled under inert atmosphere to 0°C. Hydrocinnamaldehyde (8.0 ml, 61 mmol) was added dropwise, and the solution was stirred for 10 min, quenched cautiously with saturated aqueous ammonium chloride, extracted with ether, washed with saturated brine, dried over MgSO 4 , and concentrated to give 9.82 g (98.6%) of the crude desired product. B. 3-(t-Butyldimethylsilyloxy)-5-phenyl-1-pentene. A solution of the resultant compound of Example 6A (9.82 g, 60.6 mmol) and 8.2 g (120 mmol) of imidazole in 30 ml of dimethylformamide was treated with cooling (cold water bath) with 10 g (66 mmol) of t-butyldimethylsilyl chloride and stirred at ambient temperature. After 1 h, the solution was diluted with 1:1 ether:hexane, washed with three portions of water, dried over MgSO 4 , and concentrated in vacuo. Flash chromatography using 3% ethyl acetate in hexane gave 13.2 g (79%) of the desired compound as a colorless oil. 1 H NMR (CDCl 3 ) δ 0.04 (s, 3 H), 0.07 (s, 3 H), 0.90 (s, 9 H), 1.81 (m, 2 H), 2.66 (m, 2 H), 4.16 (q, J = 6 Hz, 1 H), 5.07 (dt, J = 10, 1 Hz, 1 H), 5.18 (dt, J = 17, 1 Hz, 1 H), 5.84 (ddd, J = 17, 10, 6 Hz, 1 H), 7.1-7.3 (m, 5 H). Mass spectrum: (M+H) + = 277. C. 2-(t-Butyldimethylsilyloxy)-4-phenylbutyraldehyde. A solution of 0.81 g (2.93 mmol) of the resultant compound of Example 6B in 20 ml of dichloromethane and 10 ml of methanol was cooled to -78°C. A mixture of ozone in air was bubbled through the solution until a blue color persisted. Air was bubbled through the solution to discharge excess ozone, and the solution was treated with dimethylsulfide. After being stirred overnight at ambient temperature, the solution was diluted with dichloromethane, washed with water, dried over MgSO 4 , and concentrated in vacuo to give 0.81 g (100%) of the crude desired product. D. (Z)-Methyl 4-(t-Butyldimethylsilyloxy)-6-phenyl-2-hexenoate. A suspension of 120 mg (3.0 mmol) of sodium hydride (60% suspension in oil) in 20 ml of tetrahydrofuran was cooled to 0°C and treated with a solution of 937 mg (2.95 mmol) of bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate in 5 ml of tetrahydrofuran. The resulting solution was stirred for 10 min at 0°C, treated with a solution of 2.93 mmol of the resultant compound of Example 6C in 5 ml of tetrahydrofuran, and stirred at ambient temperature for 1 h. The solution was subsequently quenched with aqueous ammonium chloride, extracted with ether, washed with saturated brine, dried over MgSO 4 , and concentrated in vacuo. Flash chromatography using 3% ethyl acetate in hexane gave 578 mg (59%) of the desired compound. 1 H NMR (CDCl 3 ) δ 0.02 (s, 3 H), 0.08 (s, 3 H), 0.90 (s, 9 H), 1.83 (m, 2 H), 2.64, (ddd, J = 13, 11, 6 Hz, 1 H), 2.77 (ddd, J = 13, 11, 6 Hz, 1 H), 3.70 (s, 3 H), 5.38 (br q, J = 7 Hz, 1 H), 5.72 (dd, J = 11, 1 Hz, 1 H), 6.21 (dd, J = 11, 8 Hz, 1 H), 7.15-7.3 (m, 5 H). Mass spectrum (M+H) + = 335. E. (Z)-4-(t-Butyldimethylsilyloxy)-6-phenyl-2-hexenoic Acid. A solution of 567 mg (1.69 mmol) of the resultant compound of Example 6D in 13 ml of dioxane was cooled to 0°C, treated with 6.5 ml (3.2 mmol) of 0.5 M aqueous lithium hydroxide, and stirred at ambient temperature for 24 h. The resulting solution was poured into chloroform/1 N HCl, separated, dried over MgSO 4 , and concentrated to give the desired product. 1 H NMR (CDCl 3 ) δ 0.04 (s, 3 H), 0.09 (s, 3 H), 0.91 (s, 9 H), 1.88 (m, 2 H), 2.66, (m, 1 H), 2.78 (m, 1 H), 5.31 (br q, J = 7 Hz, 1 H), 5.78 (dd, J = 12, 1 Hz, 1 H), 6.34 (dd, J = 12, 8 Hz, 1 H), 7.15-7.3 (m, 5 H). Mass spectrum (M+H) + = 321. Example 2 A. 2-(t-Butyloxycarbonylamino)-1,5-diphenylpent-3-ene. A solution of 15.1 g (54.5 mmol) of the resultant compound of Example 1 and 38 ml (220 mmol) of diisopropylethylamine in 450 ml of dry dichloromethane was cooled under N 2 atmosphere in an acetone/ice bath and treated dropwise with 8.5 ml (110 mmol) of methanesulfonyl chloride. The solution was stirred for 7 min after addition was complete, then was quenched with 400 ml of 10% citric acid. The bath was removed, and the mixture was extracted with 800 ml of ether. The organic layer was washed sequentially with 500 ml of water and 300 ml of saturated brine, dried over MgSO 4 , and concentrated in vacuo to give the crude mesylate as an off-white solid. To a flame-dried 3-neck 1000 mL flask equipped with an internal low-temperature thermometer was added 1.45 g (16 mmol) of anhydrous cuprous cyanide. The flask was then charged with 500 ml of anhydrous tetrahydrofuran. The suspension was cooled under N 2 altmosphere in a dry ice/acetone bath. A solution of phenylmagnesium bromide (55 ml, 165 mmol) in ether (3M) was added via syringe. The bath was removed, and the resulting beige suspension was warmed with stirring by use of a water bath. As the internal temperature reached -5°C, the solid began to dissolve, and the solution began to turn darker. By the time the internal temperature reached -1°C, the solution was homogenous, and was immediately recooled by placement of the flask in a dry ice/acetone bath. As the internal temperature reached -65°C, addition of a solution of the above crude mesylate in 75 ml of tetrahydrofuran was added via cannula. The resulting solution was stirred at ca. -70°C for 15 min. The bath was then removed, and the solution was immediately treated with 100 ml of saturated aqueous ammonium chloride followed by 300 ml of ether. As the mixture warmed, 100 ml of 1 N NH 4 OH was added, and the mixture was stirred under air atmosphere for several hours while the aqueous layer turned dark blue. The mixture was then extracted with 500 ml of ether. The organic layer was washed with saturated brine and concentrated in vacuo without drying to give a yellow oil. The combined aqueous layers were extracted with 500 ml of additional ether, which was added to the above oil. The resulting solution was washed with saturated brine, dried over MgSO 4 , and concentrated to a yellow oil. The oil was taken up in 100 ml of dichloromethane, treated with 50 g of silica gel, and concentrated in vacuo until the residue was a freely flowing solid. The solid was placed on top of a 60 mm column containing 300 g of silica gel and eluted sequentially with 1200 ml of hexane (to bring out biphenyl formed as a side product) followed by 5000 ml of 5% ethyl acetate in hexane. Combination of the pure fractions gave 11.95 g (65%) of the desired compound. 1 H NMR (CDCl 3 , major isomer) δ 1.40 (s, 9 H), 2.7-2.9 (m, 2 H), 3.32 (d, J = 7 Hz, 2 H), 4.4 (br, 2 H), 5.43 (dd, J = 15, 6 Hz, 1 H), 5.64 (dt, J = 15, 7 Hz, 1 H), 7.0-7.3 (m, 10 H). B. 2-(t-Butyloxycarbonylamino)-1,5-diphenylpent-3-ene-3,4-oxide. A solution of 11.71 g (34.75 mmol) of the resultant compound of Example 2A in 200 ml of dichloromethane was treated with 15 g (174 mmol) of solid sodium bicarbonate, cooled to 0°C, and treated with 24 g (69 mmol) of m-chloroperbenzoic acid (50%). The resulting suspension was sealed with a septum and stirred in a cold room (5°C) for three days. The resulting mixture, which contained much precipitate, was decanted into a 1000 ml flask. The white residue was broken up and washed out with 400 ml of 10% sodium thiosulfate solution and 300 ml of ether. The two-phase mixture was stirred for 2 hours, and the layers were separated. The organic layer was washed sequentially with 200 ml portions of 2 M NaOH, water, and saturated brine. The combined aqueous layers were extracted with 200 ml of ether, which was washed sequentially with 50 ml of water and 50 mL of aqueous brine, combined with the original organic phase, dried over MgSO 4 , and concentrated in vacuo. The resulting oil was taken up in 100 ml of dichloromethane, treated with 50 g of silica gel, and concentrated in vacuo until the residue was a freely flowing solid. The solid was placed on top of a 60 mm column containing 300 g of silica gel and eluted sequentially with 1000 ml of 5% ethyl acetate in hexane followed by 3500 ml of 12% ethyl acetate in hexane. Concentration of the combined fractions gave 9.36 g (76%) of the desired compound ( ca . 4:1 mixture of diastereomers) as an oil which solidified upon standing. C. 4-Azido-2-(t-butyloxycarbonylamino)-1,5-diphenyl-3-hydroxypentane. A solution of 9.12g (25.84 mmol) of the resultant compound of Example 2B 7.0 g (140 mmol) of lithium azide, and 1.73 g (32 mmol) of ammonium chloride in 75 ml of dimethylformamide and 7.5 ml of water was heated in an oil bath at 70°C for 32 hours. After being allowed to cool, the resulting solution was treated with 1000 ml of 1:1 ether/hexane and 800 ml of water. The layers were separated, and the aqueous layer was extracted with 500 ml of additional 1:1 ether/hexane. The combined organic layers were washed sequentially with 400 ml of water and 200 ml of saturated brine, dried over MgSO 4 , and concentrated in vacuo to a solid. The solid was taken up in 100 ml of dichloromethane, treated with 50 g of silica gel, and concentrated in vacuo until the residue was a freely flowing solid. The solid was placed on top of a 60 mm column containing 300 g of silica gel and eluted sequentially with 1000 ml of 10% ethyl acetate in hexane, 1000 ml of 15% ethyl acetate in hexane, and 2000 ml of 25% ethyl acetate in hexane. Concentration of the fractions gave 9.26 g (91%) of the desired compound as a ca . 4:1 mixture of diastereomers. 1 H NMR (CDCl 3 ) δ 1.42 (s, 9 H), 2.78 (m, 1 H), 2.89 (m, 1 H), 3.13 (m, 1 H), 3.29 (m, 1 H), 3.41 (m, 1 H), 3.53 (m, 1 H), 3.80 (m, 1 H), 4.06 (m, 1 H), 4.83 (m, 1 H), 7.2-7.35 (m, 10 H). Mass spectrum (M+H) + = 338. Example 3 4-Amino-2-(t-butyloxycarbonylamino)-1,5-diphenyl-3-hydroxypentane. A rapidly stirring suspension of 10 mg of 10% palladium on carbon in 0.3 ml of methanol was treated under inert atmosphere with 60 mg (0.95 mmol) of solid ammonium formate. After 3 min, a solution of 52 mg (0.13 mmol) of the resultant compound of Example 2C in 0.4 ml of methanol was added. The resulting mixture was stirred for 2 h, diluted with methanol and 1 N ammonium hydroxide, filtered through Celite, and concentrated in vacuo. The residue was treated with 1 N NaOH, extracted with two portions of chloroform, dried over sodium sulfate, and concentrated. Flash chromatography using 7.5% methanol in chloroform gave 37 mg (76%) of the desired compound (R f 0.38, 2.5% methanol/2% isopropylamine in chloroform) as a white solid, m.p. 134-135°C. 1 H NMR (CDCl 3 ) δ 1.48 (s, 9 H), 2.50 (dd, J = 13, 10 Hz, 1 H), 2.8-3.1 (m, 4 H), 3.41 (br d, J = 7 Hz, 1 H), 4.11 (br q, J = 8 Hz, 1 H), 4.83 (br d, J = 9 Hz, 1 H), 7.15-7.35 (m, 10 H). Mass spectrum (M+H) + = 370. Anal. Calcd. for C 22 H 30 N 2 O 3 ·0.15H 2 O: C, 70.81; H, 8.18; N, 7.51. Found: C, 70.89; H, 8.15; N, 7.43. Example 4 2,4-Diamino-1,5-diphenyl-3-hydroxypentane. The resultant compound of Example 3 (18 mg, 0.049 mmol) was treated with 1 ml of 4 M HCl in dioxane, stirred for 0.5 h at ambient temperature, and concentrated in vacuo. The residue was partitioned between chloroform and aqueous NaHCO 3 , dried over Na 2 SO 4 and concentrated to provide the desired compound (R f 0.12, 10% methanol in chloroform) as a white solid, m.p. 106-107°C. 1 H NMR (CDCl 3 ) δ 2.51 (dd, J = 13, 10 Hz, 1 H), 2.67 (dd, J = 13, 9 Hz, 1 H), 2.85-3.0 (m, 2 H), 3.19 (m, 1 H), 3.38 (m, 2 H), 7.15-7.35 (m, 10 H). Mass spectrum: (M + H) + = 271. Example 5 A. 2,2-Dimethyl-4,5-di-(2-phenyl-1-oxoethyl)-1,3 dioxolane. A solution of 7.5 g (20.5 mmol) of N,N,N',N',-tetramethyl-O,O'-isopropylidene-d-tartaric diamide (Briggs, et. al., J. Chem. Soc. Perkin Trans. I , 1985 , 795) in 150 ml of tetrahydrofuran was treated over a period of 20 min with 41 ml (82 mmol) of benzylmagnesium chloride. The resulting solution was stirred overnight at ambient temperature, poured over ice/saturated ammonium chloride, extracted with ethyl acetate, dried over MgSO 4 , and concentrated in vacuo. Flash chromatography using 20% ethyl acetate in hexane gave 0.83 g (12%) of the desired compound as an oil. 1 H NMR (CDCl 3 ) δ 1.45 (s, 6 H), 3.94 (s, 4 H), 4.70 (s, 2 H), 7.2-7.4 (m, 10 H). Mass spectrum (M+H) + = 339. B. 3,4-Dihydroxy-1,6-diphenylhexan-2,5-dione. The resultant compound of Example 5A (100 mg, 0.3 mmol) was treated with 10 ml of 80% aqueous acetic acid, heated at reflux for 5 min, allowed to cool, and concentrated in vacuo. The crude product was purified by flash chromatography using 20% ethyl acetate in hexane to give 65 mg (74%) of the desired compound (R f 0.15, 30% ethyl acetate in hexane). 1 H NMR (CDCl 3 ) δ 2.39 (d, J = 5 Hz, 1 H), 2.81 (d, J = 3 Hz, 1 H), 3.89 (d, J = 15 Hz, 2 H), 4.13 (d, J = 15 Hz, 2 H), 4.40 (br t, J = 3 Hz, 1 H), 4.66 (m, 1 H), 7.15-7.5 (m, 10 H). Mass spectrum (M+H) + = 299. Example 6 A. (Z)-(4-(t-Butyldimethylsilyloxy)-6-phenyl-2-hexenoyl)-Val-Val Amide. A solution of the resultant compound of Example 1E (57 mg, 0.18 mmol) and 0.022 ml of 4-methylmorpholine in 3 ml of dichloromethane was cooled to 0°C and treated with 0.026 ml (0.19 mmol) of isobutyl chloroformate. The resulting solution was stirred for 10 min, treated with a solution of 41 mg (0.19 mmol) of H-Val-Val-NH 2 in 1.5 ml of dimethylformamide, and stirred at ambient temperature for 2 h. The solution was subsequently diluted with ethyl acetate, washed sequentially with 10 % aqueous citric acid and aqueous NaHCO 3 , dried over MgSO 4 , and concentrated. Flash chromatography using 60% ethyl acetate in chloroform gave 53 mg (57%) of the desired compound as a 1:1 mixture of diastereomers. Example 7 2-(t-Butyloxycarbonylamino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. A solution of 39 mg (0.16 mmol) of Cbz-Val-OH, 52 mg (0.14 mmol) of the resultant compound of Example 3, and 23 mg (0.17 mmol) of 1-hydroxybenzotriazole in 2 ml of dimethylformamide was treated with 0.019 ml (0.17 mmol) of 4-methylmorpholine, cooled to 0°C, and treated with 33 mg (0.17 mmol) of N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride. After being stirred at ambient temperature overnight, the solution was diluted with ethyl acetate, washed sequentially with 10% citric acid, water, and aqueous NaHCO 3 , dried over Na 2 SO 4 , and concentrated in vacuo. Separation of the desired compounds by flash chromatography using methanol in chloroform gave 80 mg (95%) of the desired compound (R f 0.40, 10% methanol in chloroform) as a white solid, m.p. 187-187.5°C. Mass spectrum (M+H) + = 604. Example 8 A. 2-Amino-4-azido-1,5-diphenyl-3-hydroxypentane Hydrochloride. The resultant compound of Example 2C (25 mg, 0.063 mmol) was treated with 1 ml of 4 M HCl in dioxane, stirred for 0.5 h at ambient temperature, and concentrated in vacuo to give the desired compound. Example 9 2-Amino-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 8 with the resultant compound of Example 7 gave, after silica gel chromatography using methanol/ isopropylamine/ chloroform, the desired compound (R F 0.3; 2.5% methanol/ 2% isopropylamine/ chloroform) in 100% yield, m.p. 158-160°C. Mass spectrum (M+H) + = 504. Example 10 2,4-Bis-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 7 but replacing the resultant compound of Example 3 with the resultant compound of Example 9 gave, after silica gel chromatography using methanol/ chloroform, the desired compound (R F 0.4; 2.5% methanol/ 2% isopropylamine/chloroform) in 98% yield, m.p. 198-200°C. Mass spectrum (M+H) + = 737. Anal. Calcd. for C 43 H 52 N 4 O 7 ·0.5H 2 O: C, 69.24; H, 7.16; N, 7.51. Found: C, 69.40; H, 7.29; N, 7.47. Example 11 A. N-Boc-valinyl-valine benzyl ester. Boc-Val-OH (2.86 g, 13.2 mmol) was coupled to valine benzyl ester p-toluenesulfonate (5.0 g, 13.2 mmol) using the procedure of Example 55 to give 5.41g, (100%) of the desired product (R F 0.15; 20% ethyl acetate in hexane) as a colorless gum. Mass spectrum (M+H) + = 407. B. N-(5-Carbomethoxypentanoyl)-valinyl-valine benzyl ester. The resultant compound of Example 11A (0.50 g, 1.23 mmol) was deprotected according to the procedure of Example 8 and coupled to adipic acid monomethyl ester (0.21 g, 1.28 mmol) using the mixed anhydride procedure of Example 54A to give, after flash chromatography using 40% ethyl acetate in chloroform, 0.53 g (96%) of the desired compound. C. N-(5-Carbomethoxypentanoyl)-valinyl-valine. A mixture of the resultant compound of Example 11B (0.53 g, 1.18 mmol) and 100 mg of 10% palladium on carbon in 30 ml of methanol was stirred under one atmosphere of hydrogen. After 5 h, the mixture was filtered through Celite and concentrated to give 0.40 g (93%) of the desired compound as a solid. Example 12 2,4-Bis-N-(valinyl)amino-1,5-diphenyl-3-hydroxypentane. The resultant compound of Example 10 was hydrogenolyzed according to the procedure of Example 11C to provide the desired compound (R f 0.1, 10% methanol in chloroform) as a white solid, m.p. 131-132°C. Example 13 2,4-Bis-(Cbz-valinyl-amino)-1,5-diphenyl-3-((methoxy)methoxy)pentane. A solution of 22 mg of the resultant compound of Example 10 in 1 ml of dichloromethane was treated with 0.07 ml of ethyldiisopropylamine and 0.03 ml of chloromethyl methyl ether. The resulting solution was heated at reflux for 1 h. The cooled solution was concentrated in vacuo to give 26 mg of a crude solid which was recrystallized from ethyl acetate/chloroform to provide 15 mg of the desired compound (R f 0.6, 10% methanol in chloroform) as a white solid, m.p. 197-198°C. Mass spectrum: (M + H) + = 781. Anal. Calcd for C 45 H 56 N 4 O 8 ·1.5H 2 O: C, 66.89; H, 7.36; N, 6.93. Found: 66.96; H, 6.76; N, 6.77. Example 14 A. α-Isocyanato-valine Methyl Ester . A suspension of L-valine methyl ester hydrochloride (10 g) in toluene (400 ml) was heated to 100°C and phosgene gas was bubbled into the reaction mixture. After approximately 6 h, the mixture became homogeneous. The bubbling of phosgene was continued for 10 more min, then the solution was cooled with the bubbling of N 2 gas. The solvent was then evaporated and the residue chased with toluene two times. Evaporation of solvent gave 14.2 g of the crude desired compound. B. N-((4-Pyridinyl)methoxycarbonyl)-valine Methyl Ester. A solution of 0.73 g (4.65 mmol) of the resultant compound of Example 14A and 0.51 g (4.65 mmol) of pyridine-4-methanol in 30 mL of toluene was heated at reflux under N 2 atmosphere for 4 h. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography using 2% methanol in chloroform to give 1.01 g (82%) of the desired compound as an oil. 1 H NMR (CDCl 3 ) δ 0.91 (d, J = 7 Hz, 3 H), 0.99 (d, J = 7 Hz, 3 H), 2.19 (m, 1 H), 3.76 (s, 3 H), 4.31 (dd, J = 9, 5 Hz, 1 H), 5.12 (s, 2 H), 5.37 (br d, 1 H), 7.25 (d, J = 6 Hz, 2 H), 8.60 (d, J = 6 Hz, 2 H). C. N-((4-Pyridinyl)methoxycarbonyl)-vaiine Lithium Salt. A solution of 50.8 mg (0.191 mmol) of the resultant compound of Example 14B in 0.75 ml of dioxane was treated with 0.46 ml (0.23 mmol) of 0.5 M aqueous lithium hydroxide. The resulting solution was stirred overnight at ambient temperature and concentrated in vacuo to provide the desired compound. D. 2-(N-((4-Pyridinyl)methoxycarbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. A solution of the resultant compound of Example 14C (0.191 mmol), 94 mg (0.97 mmol) of the resultant compound of Example 9, and 31 mg (0.23 mmol) of 1-hydroxybenzotriazole in 2 ml of dimethylformamide was treated under N 2 atmosphere with 44 mg (0.23 mmol) of N-ethyl-N'-(dimethylaminopropyl) carbodiimide hydrochloride and stirred overnight at ambient temperature. The resulting solution was taken up in ethyl acetate, washed sequentially with aqueous NaHCO 3 , H 2 O, and saturated brine, dried over Na 2 SO 4 , and concentrated in vacuo. Chromatography on silica gel using 3% methanol in chloroform provided 119 mg (87%) of the desired compound (R f 0.19, 5% methanol in chloroform) as a white solid, m.p. 170-172°C (dec). Mass spectrum: (M + 1) + = 738. Anal. Calcd for C 42 H 51 N 5 O 7 ·0.5H 2 O: C, 67.54; H, 7.02; N, 9.38. Found: C, 67.53; H, 7.00; N, 9.39. Example 15 A. N-((3-Pyridinyl)methoxycarbonyl)-valine Methyl Ester. Using the procedure of Example 14B but replacing pyridine-4-methanol with pyridine-3-methanol provided the desired compound as an oil after silica gel chromatography using 2% methanol in chloroform. 1 H NMR (CDCl 3 ) δ 0.90 (d, J = 7 Hz, 3 H), 0.98 (d, J = 7 Hz, 3 H), 2.16 (m, 1 H), 3.65 (s, 3 H), 4.30 (dd, J = 9, 5 Hz, 1 H), 5.14 (s, 2 H), 5.30 (br d, 1 H), 7.30 (dd, J = 8, 5 Hz, 1 H), 7.70 (br d, J = 8 Hz, 1 H), 8.58 (dd, J = 4, 1 Hz, 1 H), 8.63 (br s, 1 H). B. N-((3-Pyridinyl)methoxycarbonyl)-valine Lithium Salt. Using the procedure of Example 14C with the resultant compound of Example 15A provided the desired compound. C. 2-(N-((3-Pyridinyl)methoxycarbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxynentane. Using the procedure of Example 14D but replacing the resultant compound of Example 14C with the resultant compound of Example 15B provided, after silica gel chromatography using 3% methanol in chloroform, 113 mg (94%) of the desired compound (R f 0.21, 5% methanol in chloroform) as a white solid, m.p. 177-178°C. Mass spectrum: (M + 1) + = 738. Anal. Calcd for C 42 H 51 N 5 O 7 ·0.5H 2 O: C, 67.54; H, 7.02; N, 9:38. Found: C, 67.35; H, 6.90; N, 9.35. Example 16 A. N-((2-Pyridinyl)methoxycarbonyl)-valine Methyl Ester. Using the procedure of Example 14B but replacing pyridine-4-methanol with pyridine-2-methanol provided 0.72 g (54%) of the desired compound as an oil after silica gel chromatography using 2% methanol in chloroform. 1 H NMR (CDCl 3 ) δ 0.91 (d, J = 7 Hz, 3 H), 0.98 (d, J = 7 Hz, 3 H), 2.19 (m, 1 H), 3.75 (s, 3 H), 4.32 (dd, J = 9, 5 Hz, 1 H), 5.24 (s, 2 H), 5.39 (br d, 1 H), 7.23 (ddd, J = 8, 4, 1 Hz, 1 H), 7.37 (d, J = 8 Hz, 1 H), 7.70 (td, J = 8, 2 Hz, 1 H), 8.60 (br d, 1 H). B. N-((2-Pyridinyl)methoxycarbonyl)-valine Lithium Salt. Using the procedure of Example 14C with the resultant compound of Example 16A provided the desired compound. C. 2-(N-((2-Pyridinyl)methoxycarbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 14D but replacing the resultant compound of Example 14C with the resultant compound of Example 16B provided, after silica gel chromatography using 2% methanol in chloroform, 119 mg (99%) of the desired compound28, 5% methanol in chloroform) as a white solid, m.p. 194-195°C. Mass spectrum: (M + 1) + = 738. Anal. Calcd for C 42 H 51 N 5 O 7 ·0.5H 2 O: C, 67.54; H, 7.02; N, 9.38. Found: C, 67.31; H, 7.00; N, 9.37. Example 17 A. N-((2-(4-Morpholinyl)ethyloxy)carbonyl)-valine Methyl Ester. A solution of 1.04 g (6.60 mmol) of the resultant compound of Example 14A and 0.88 ml (7.25 mmol) of 4-(2-hydroxyethyl)morpholine in 30 mL of toluene was heated at reflux under N 2 atmosphere for 12 h. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography using 5% methanol in chloroform to give 1.41 g (71%) of the desired compound as an oil. 1 H NMR (CDCl 3 ) δ 0.89 (d, J = 7 Hz, 3 H), 0.96 (d, J = 7 Hz, 3 H), 2.16 (m, 1 H), 2.50 (br t, 4 H), 2.62 (t, J = 6 Hz, 2 H), 3.72 (t, J = 6 Hz, 4 H), 3.75 (s, 3 H), 4.20 (br t, 2 H), 4.37 (dd, J = 9, 5 Hz, 1 H), 5.25 (br d, 1 H). B. N-((2-(4-Morpholinyl)ethyloxy)carbonyl)-valine Lithium Salt. A solution of 77.7 mg (0.27 mmol) of the resultant compound of Example 17A in 1 ml of dioxane was treated with 1.04 ml (0.52 mmol) of 0.5 M aqueous lithium hydroxide. After being stirred for 2.5 h at ambient temperature, the resulting solution was treated with 0.26 ml (0.26 mmol) of 1 N aqueous HCl and concentrated in vacuo to provide the desired compound as a white solid. C. 2-(N-((2-(4-Morpholinyl)ethyloxy)carbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 14D but replacing the resultant compound of Example 14C with the resultant compound of Example 17B provided, after silica gel chromatography using 4% methanol in chloroform, 150 mg (94%) of the desired compound (R f 0.34, 7.5% methanol in chloroform) as a white solid, m.p. 159-161°C. Mass spectrum: (M + 1) + = 760. Anal. Calcd for C 42 H 57 N 5 O 8 ·0.75H 2 O: C, 65.22; H, 7.62; N, 9.05. Found: C, 65.19; H, 7.49; N, 9.08. Example 18 A. N-((2-(1-Pyrrolidinyl)ethyloxy)carbonyl)-valine Methyl Ester. Using the procedure of Example 17A but replacing 4-(2-hydroxyethyl)morpholine with 4-(2-hydroxyethyl)pyrrolidine provided, after silica gel chromatography using 6% methanol in chloroform, 1.14 g (80%) of the desired compound as an oil. 1 H NMR (CDCl 3 ) δ 0.90 (d, J = 7 Hz, 3 H), 0.96 (d, J = 7 Hz, 3 H), 1.80 (m, 4 H), 2.15 (m, 1 H), 2.57 (m, 4 H), 2.63 (t, J = 6 Hz, 2 H), 3.74 (s, 3 H), 4.20 (br t, 2 H), 4.28 (dd, J = 9, 5 Hz, 1 H), 5.30 (br d, 1 H). B. N-((2-(1-Pyrrolidinyl)ethyloxy)carbonyl)-valine Lithium Salt. Using the procedure of Example 17B with the resultant compound of Example 18A provided the desired compound as a white solid. C. 2-(N-((2-(1-Pyrrolidinyl)ethyloxy)carbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 14D but replacing the resultant compound of Example 14C with the resultant compound of Example 18B provided, after silica gel chromatography using 7.5% methanol in chloroform, 103 mg (63%) of the desired compound (R f 0.13, 7.5% methanol in chloroform) as a white solid, m.p. 143-146°C. Mass spectrum: (M + 1) + = 744. Anal. Calcd for C 42 H 57 N 5 O 7 : C, 67.81; H, 7.72; N, 8.89. Found: C, 68.20; H, 7.53; N, 8.89. Example 19 A. N-((2-Furanyl)methoxycarbonyl)-valine Methyl Ester. Using the procedure of Example 17A but replacing 4-(2-hydroxyethyl)morpholine with 2-furfuryl alcohol provided, after silica gel chromatography using 20% ethyl acetate in hexane, 0.91 g (70%) of the desired compound as an oil. 1 H NMR (CDCl 3 ) δ 0.88 (d, J = 7 Hz, 3 H), 0.96 (d, J = 7 Hz, 3 H), 2.15 (m, 1 H), 3.74 (s, 3 H), 4.29 (dd, J = 9, 5 Hz, 1 H), 5.07 (s, 2 H), 5.25 (br d, 1 H) 6.36 (m, 1 H), 6.42 (m, 1 H), 7.43 (m, 1 H). B. N-((2-Furanyl)methoxycarbonyl)-valine. Using the procedure of Example 17B with the resultant compound of Example 19A provided, after acidification and extraction into chloroform, the desired compound as a white solid. C. 2-(N-((2-Furanyl)methoxycarbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 14D but replacing the resultant compound of Example 14C with the resultant compound of Example 19B provided the desired compound. Example 20 A. N-(((1-Methyl)pyrrolidin-2-yl)methoxycarbonyl)-valine Methyl Ester. Using the procedure of Example 17A but replacing 4-(2-hydroxyethyl)morpholine with 1-methyl-2-pyrrolidine-methanol provided, after silica gel chromatography using 5% methanol in chloroform, the desired compound as an oil. 1 H NMR (CDCl 3 ) δ 0.90 (d, J = 7 Hz, 3 H), 0.96 (d, J = 7 Hz, 3 H), 1.6-2.0 (m, 34 H), 2.15 (m, 1 H), 2.23 (td, J = 9, 8 Hz, 1 H), 2.40 (s, 3 H), 2.53 (m, 1 H), 3.03 (m, 1 H), 3.74 (s, 3 H), 4.00 (dd, J = 12, 6 Hz, 1 H), 4.17 (dd, J = 12, 5 Hz, 1 H), 4.28 (dd, J = 9, 5 Hz, 1 H), 5.27 (br d, 1 H). B. N-(((1-Methyl)pyrrolidin-2-yl)methoxycarbonyl)-valine Lithium Salt. Using the procedure of Example 17B with the resultant compound of Example 20A provided the desired compound as a white solid. C. 2-(N-(((1-Methyl)pyrrolidin-2-yl)methoxycarbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 14D but replacing the resultant compound of Example 14C with the resultant compound of Example 20B provided, after silica gel chromatography using methanol in chloroform, the desired compound. Example 21 (2S,3R,4R,5S)-2,5-Diamino-3,4-dihydroxy-1,6-diphenylhexane. (2S,3R,4R,5S)-2,5-Di-(N-((t-butyloxy)carbonyl)amino)-3,4-dihydroxy-1,6-diphenylhexane (2.7 g, 5.4 mmol) was treated with 200 ml of 6N aqueous hydrochloric acid and heated to 90°C until the solid had completely dissolved (30 min). The resulting solution was cooled, concentrated in vacuo, treated with saturated brine and 3N aqueous NaOH, extracted with chloroform, dried over Na 2 SO 4 , and concentrated in vacuo. Silica gel chromatography using 3% methanol/2% isopropylamine in chloroform provided the pure desired compound (R f 0.40, 5% methanol/2% isopropylamine in chloroform) as a white solid, m.p. 86-89°C. 1 H NMR (CDCl 3 ) δ 2.72 (dd, J = 14, 9 Hz, 2 H), 2.92 (dd, J = 14, 6 Hz, 2 H), 3.03 (dd, J = 9, 5 Hz, 2 H), 3.69 (s, 2 H), 7.15-7.35 (m, 10 H). Mass spectrum: (M + H) + = 301. Anal. Calcd for C 18 H 24 N 2 O 2 ·0.25H 2 O: C, 70.91; H, 8.10; N, 9.19. Found: C, 70.52; H, 7.92; N, 8.93. Example 22 A. N-((Cbz-valinyl)oxy)-succinimide A suspension of 3.40 g (13.5 mmol) of Cbz-valine and 1.56 g (13.5 mmol) of N-hydroxysuccinimide in 200 ml of dichloromethane was treated with 2.86 g (14.9 mmol) of N-ethyl-N'-(dimethylaminopropyl) carbodiimide hydrochloride and stirred at ambient temperature for 4 h. The resulting solution was washed sequentially with 10% citric acid, aqueous NaHCO 3 , and water; dried over Na 2 SO 4 , and concentrated in vacuo to provide 4.00 g (85%) of the desired compound. B. (2S,3R,4R,5S)-2,5-Di-(N-(Cbz-valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane. A solution of 28.7 mg (0 096 mmol) of the resultant compound of Example 21 in 1 ml of dioxane was treated with 139 mg (0.40 mmol) of the resultant compound of Example 22A and stirred at ambient temperature for 24 h. The resulting solution was treated with 0.5 ml of 3N NaOH, stirred for 15 min, extracted with two portions of 10% methanol in chloroform, dried over Na 2 SO 4 , and concentrated in vacuo. The residue was chromatographed on silica gel using 3% methanol in chloroform to provide 42.4 mg (58%) of the desired compound (R f 0.35, 5% methanol in chloroform) as a white solid, m.p. 231-232°C. Mass spectrum: (M + H) + = 767. Anal. Calcd for C 44 H 54 N 4 O 8 ·0.25H 2 O: C, 68.51; H, 7.12; N, 7.26. Found: C, 68.48; H, 7.11; N, 7.12. Example 23 A. N-((4-Pyridinyl)methoxycarbonyl)-valine. Using the procedure of Example 14C but adding twice the amount of 1M HCl provided the desired compound. B. 2,4-Di-(N-((4-pyridinyl)methoxycarbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. The resultant compound of Example 23A (0.60 mmol) was coupled to the resultant compound of Example 4 (60 mg, 0.22 mmol) using the procedure of Example 7 except that the reaction was allowed to proceed for 2 days at ambient temperature. Silica gel chromatography using methanol/chloroform provided the desired compound (R f 0.44, 10:1 chloroform:methanol) as a white solid, m.p. 158-159°C. Mass spectrum: (M + H) + = 741. Anal. Calcd for C 41 H 50 N 6 O 7 ·0.5H 2 O: C, 65.85; H, 6.87; N, 11.24. Found: C, 6.76; H, 65.67; N, 11.12. Example 24 A. N-((3-Pyridinyl)methoxycarbonyl)-valine. Using the procedure of Example 15B but adding twice the amount of 1M HCl provided the desired compound. B. 2,4-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 23B but replacing the resultant compound of Example 23A (0.60 mmol) with the resultant compound of Example 24A gave, after silica gel chromatography using methanol/chloroform, the desired compound (R f 0.53, 10:1 chloroform:methanol) as a white solid, m.p. 177-178°C. Mass spectrum: (M + H) + = 741. Anal. Calcd for C 41 H 50 N 6 O 7 ·0.5H 2 O: C, 65.85; H, 6.87; N, 11.24. Found: C, 66.09; H, 6.72; N, 11.24. Example 25 A. N-((2-Pyridinyl)methoxycarbonyl)-valine. Using the procedure of Example 16B but adding twice the amount of 1M HCl provided the desired compound. B. 2,4-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 23B but replacing the resultant compound of Example 23A (0.60 mmol) with the resultant compound of Example 25A gave, after silica gel chromatography using methanol/chloroform, the desired compound as a white solid, m.p. 155-156°C. Mass spectrum; (M + H) + = 741. Anal. Calcd for C 41 H 50 N 6 O 7 ·0.5H 2 O: C, 65.85; H, 6.87; N, 11.24. Found: C, 65.89; H, 6.90; N, 11.24. Example 26 A. Ethyl 4(S)-((t-Butyloxycarbonyl)amino)-5-cyclohexyl-2,2-difluoro-3(R,S)-hydroxypentanoate. To a suspension of 1.2 g (17 mmol) of activated zinc in 5 ml of tetrahydrofuran under argon in a sonicating bath was added slowly a solution of 1.7 g (6.8 mmole) of Boc-L-cyclohexylalaninal and 2.34 ml (18.4 mmole) of ethyl bromodifluoroacetate in 30 ml of tetrahydrofuran. After complete addition, the solution was sonicated for an additional 30 min. The mixture was then added to 1 M KHSO 4 and extracted with dichloromethane (3 x 100 ml), dried with Na 2 SO 4 , filtered and concentrated in vacuo . The residual oil was purified by silica gel column chromatography (15-30% ethyl acetate in hexane) to give 1.22 g (75%) of two diastereomers. 3(R) diastereomer: 1 H NMR (CDCl 3 ) δ 1.37 (t, 3H, J=7.0 Hz), 1.46 (S, 9H), 4.35 (q, 2H, J=7.0 Hz); m.p. 73-74.5°C. Anal. (C 18 H 31 NO 5 F 2 ) C,H.N. 3(S) diastereomer: 1 H NMR (CDCl 3 ) δ 1.37 (t, 3H, J=7.5 Hz), 1.45 (S, 9H), 4.31 (q, 2H, J=7.5 Hz); m.p. 115-117°C. Anal. (C 18 H 31 NO 5 F 2 ) C,H,N. B. 2-Oxazolidinone derivative of Ethyl 4(S)-amino-5-cyclohexyl-2,2-difluoro-3(R)-hydroxypentanoate. To 50 mg of the resultant 3(R) isomer of Example 26A was added 1 ml of 4 M HCl in dioxane. The solution was stirred at ambient temperature for 30 min. The concentrated residue was dissolved in dichloromethane and treated with 0.1 ml of triethylamine and excess phosgene in toluene (10% solution). After stirring at ambient temperature for 1 hr, the crude product was purified by silica gel column chromatography (10% ethyl acetate in hexane) to give 32 mg of desired compound. 1 H NMR (CDCl 3 ) d 1.38 (t, 3H, J=7 Hz), 4.08 (m, 1H), 4.38 (q, 2H, J=7 Hz), 4.58 (ddd, 1H, J=4.5, 6.0, 15 Hz), 6.05 (br S, 1H). Anal. (C 14 H 21 NO 4 F 2 ) C,H,N. C. 4(S)-cyclohexylmethyl-5(R)-(4'(4',4'-difluoro-3'-oxo-2'-methyl-butyl))-2-oxazolidinone. The hydrolysis of 2.5 g of the resultant compound of Example 26B by lithium hydroxide in aqueous methanol provided 2.3 g of the corresponding carboxylic acid. The acid was dissolved in 40 ml of tetrahydrofuran and cooled to -78°C. To the vigorously stirred solution was added 18 ml of isopropyl lithium solution in pentane (12.4% by wt.). After 30 min, the solution was slowly warmed to 0°C. and stirred for an additional 30 min. The reaction was carefully quenched with water and extracted with ethyl acetate (3 x 100 ml), dried and concentrated in vacuo . The crude product was purified by silica gel column chromatography (20% ethyl acetate in hexane) to give 1.36 g of desired product. 1 H NMR (CDCl 3 ) d 1.20 (t, 6H, J=6.3 Hz), 3.17 (d of heptet, 1H, J=1.8, 6.6 Hz), 4.06 (m, 1H), 4.62 (ddd, 1H, J=4.5, 6.0, 20.4 Hz), 5.63 (br S, 1H). Anal. (C 14 H 23 NO 3 F 2 ) C,H,N. D. Oxime derivative of 4(S)-cyclohexylmethyl-5(R)-(4'(4',4'-difluoro-3'oxo-2'-methyl-butyl))-2-oxazolidinone. To a solution of 1.2 g of the resultant compound of Example 26C in 20 ml of ethanol was added 0.55 ml of pyridine and then 410 mg of hydroxyamine hydrochloride. The solution was heated to reflux for 5.5 hrs. The solvent was removed in vacuo and the crude product was purified by silica gel column chromatography (10% EtOAc/CH 2 Cl 2 ) to give 1.12 g of desired product. Mass spectrum: M + =318. E. 4(S)-Cyclohexylmethyl-5(R)-(4'(4',4'-difluoro-3'-amino-2-methyl-butyl))-2-oxazolidinone. To a solution of 1.1 g of the resultant compound of Example 26D in 40 ml of ethanol was added 0.5 g of activated Raney nickel. The reaction mixture was stirred vigorously under a hydrogen atmosphere for 2 h. The catalyst was filtered off and the filtrate concentrated to a oily residue. The crude product was purified by silica gel column chromatography (10% EtOAc/CH 2 Cl 2 ) to give 550 mg of desired product. Mass spectrum: M + =304. F. 3,6-Diamino-7-cyclohexyl-5-hydroxy-4,4-difluoro-2-methylheptane. To a solution of 150 mg of the resultant compound of Example 26E in 10 ml of dioxane and 10 ml of water was added 325 mg of barium hydroxide octahydrate. The reaction mixture was heated to reflux for 0.3 hrs. The suspension was cooled to ambient temperature and filtered and the solid was washed with ethyl acetate. The filtrate was washed with satd. brine and the aqueous phase was extracted with ethyl acetate (2 x 50 ml). The combined ethyl acetate solution was dried, filtered and concentrated to provide 130 mg of the desired product. Mass spectrum: M + =278. Example 27 3,6-Bis-(Cbz-valinyl-amino)-7-cyclohexyl-5-hydroxy4,4-difluoro-2-methylheptane. To a solution of 130 ml of the resultant compound of Example 26F in 10 ml of dimethylformamide was added at 0°C successively 230 mg of Cbz-valine, 220 mg of N-ethyl-N'-(dimethylaminopropyl) carbodiimide hydrochloride, 400 mg of 1-hydroxybenzotriazole and 0.16 ml of triethylamine. The solution was stirred at 0°C for 3 hrs and at ambient temperature for 12 hrs. The dimethylformamide was removed under vacuum and the residue was dissolved in 50 ml of ethyl acetate and washed with saturated. brine. The aqueous layer was extracted with ethyl acetate (2 x 50 ml) and dried, filtered and concentrated. The crude product was purified by silica gel column chromatography (2% MeOH/CH 2 Cl 2 ) to give 220 mg of the desired compound (64%) . Mass spectrum: (M+H) + =745. 1 H NMR (CDCl 3 ) d 0.78-0.90 (m, 18H), 3.60 (m, 1H), 3.85 (m, 1H), 4.00 (m, 1H), 4.40 (m, 1H), 4.55 (m, 1H), 5.03 (S, 4H), 5.78 (d, 1H), 7.25-7.36 (m, 10H), 7.69 (d, 1H). Example 28 2,5-Di-(N-(Cbz-isoleucinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane. A mixture of 10 mg (0.033 mmol) of the resultant compound of Example 21 and 38.6 mg (0.10 mmol) of Cbz-isoleucine p-nitrophenyl ester in 0.2 ml of tetrahydrofuran was stirred at ambient temperature for 21 h. The resulting misture was diluted with 1 ml of tetrahydrofuran, treated with 0.5 ml of 3N NaOH, stirred for 45 min, extracted with chloroform, washed sequentially with 3N NaOH and saturated brine, dried over MgSO 4, and concentrated. The residue was purified on silica gel by eluting with 2% methanol in chloroform to provide 23 mg (86%) of the desired compound. Mass spectrum: (M + H) + = 795. Example 29 2,5-Di-(N-(Cbz-alaninyl)amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 28 but replacing Cbz-isoleucine p-nitrophenyl ester with Cbz-alaninyloxysuccinimide provided the desired compound. Mass spectrum: (M + H) + = 711. Example 30 2,5-Di-(N-(Cbz-leucinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 28 but replacing Cbz-isoleucine p-nitrophenyl ester with Cbz-leucine p-nitrophenyl ester provided the desired compound. Mass spectrum: (M + H) + = 795. Example 31 (2S,3R,4S,5S)-2,5-Di-(N-(Cbz-valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 22B with 25 mg (0.083 mmol) of (2S , 3R,4S , 5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided the desired compound (31%, R f 0.3, 5% methanol in chloroform) as a white solid, m.p. 230-234°C. Mass spectrum: (M + H) + = 767. Example 32 (2S,3S,4S,5S)-2,5-Di-(N-(Cbz-valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane. Cbz-valine p-nitrophenyl ester was coupled to (2S,3S,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane using the procedure of Example 22B to provide the desired compound (R f 0.42, 5% methanol in chloroform) as a white solid, m.p. 239-242°C in 86 % yield. Example 33 A. N-((2-Pyridinyl)methoxycarbonyl)-valine p-Nitrophenyl Ester. A solution of 0.87 mmol of the resultant compound of Example 25A and 133 mg (0.96 mmol) of p-nitrophenol in 4 ml of tetrahydrofuran and 2 ml of dimethylformamide was treated with 183 mg (0.96 mmol) of N-ethyl-N'-(dimethylaminopropyl) carbodiimide hydrochloride and stirred at ambient temperature. After 4 h, the solvent was removed in vacuo, and the residue was partially purified by silica gel chromatography using 20% ethyl acetate in chloroform to give 0.34 mg of the desired compound contaminated with excess p-nitrophenol. B. (2S,3R,4R,5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. A solution of 230 mg of the crude resultant compound of Example 33A and 70 mg (0.23 mmol) of the resultant compound of Example 21 in 1 ml of 1:1 tetrahydrofuran/dimethylformamide was stirred at ambient temperature for 16 h. The resulting solution was treated with aqueous NaHCO 3 , stirred for 1 h, diluted with 5% methanol in chloroform, washed with aqueous NaHCO 3 until the washes were colorless, dried over Na 2 SO 4 , and concentrated. Chromatography on silica gel using 2% methanol in chloroform followed by 5% methanol in chloroform provided 140.6 mg (80%) of the desired compound (R f 0.32, 10% methanol in chloroform) as a white solid, m.p. 196-200°C. Mass spectrum: (M + H) + = 769. Anal. Calcd for C 42 H 52 N 6 O 8 : C, 65.61; H, 6.82; N, 10.93. Found: C, 65.68; H, 6.93; N, 10.95. Example 34 (2S,3S,4S,5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 21 with (2S,3S,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided, after silica gel chromatography using a gradient of 2-5% methanol in chloroform, the desired compound (R f 0.32, 5% methanol in chloroform) as a white solid, m.p. 220-223°C, in 79% yield. Mass spectrum: (M + H) + = 769. Anal. Calcd for C 42 H 52 N 6 O 8 ·0.5H 2 O: C, 64.85; H, 6.87; N, 10.80. Found: C, 64.69; H, 6.84; N, 10.63. Example 35 (2S,3R,4S,5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 21 with (2S,3R,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided, after silica gel chromatography using a gradient of 2-5% methanol in chloroform, the desired compound (R f 0.23, 5% methanol in chloroform) as a white solid, m.p. 238-240°C, in 82% yield. Mass spectrum: (M + H) + = 769. Anal. Calcd for C 42 H 52 N 6 O 8 ·0.25H 2 O: C, 65.23; H, 6.84; N, 10.87. Found: C, 65.01; H, 6.89; N, 10.92. Example 36 A. 2-(N-(t-Butyloxycarbonyl)aminomethyl)pyridine. A solution of 21.2 g (97 mmol) of di-t-butyldicarbonate in 200 ml of dichloromethane was cooled to 0°C and treated in portions with 10 ml (97 mmol) of 2-(aminomethyl)pyridine. After being allowed to warm to ambient temperature and stirred overnight, the resulting solution was diluted with 100 ml of dichloromethane, washed with three 100 ml portions of water, dried over Na 2 SO 4 , and concentrated in vacuo to provide 19.8 g (98%) of the desired compound (R f 0.28, 5% methanol in chloroform). 1 H NMR (CCDl 3 ) δ 1.47 (s, 9 H), 4.45 (d, J = 6 Hz, 2 H), 5.56 (br, 1 H), 7.18 (m, 1 H), 7.28 (d, J = 8 Hz, 1 H), 7.66 (td, J = 7, 2 Hz, 1 H), 8.53 (m, 1 H). B. 2-((N-(t-Butyloxycarbonyl)-N-methylamino)methyl)pyridine. A solution of 19.8 g (95 mmol) of the resultant compound of Example 36A in anhydrous tetrahydrofuran was cooled under N 2 atmosphere to 0°C and treated with 4.95 g (124 mmol) of sodium hydride (60% dispersion in oil). The solution was stirred for 15 min, treated dropwise with 7.1 ml (114 mmol) of methyl iodide, stirred at ambient temperature for 2 h, and quenched cautiously with water. The resulting mixture was partitioned between ether and water, dried over Na 2 SO 4 , and concentrated. Chromatography on silica gel provided 14.9 g (70%) of the desired compound as a colorless oil. C. 2-(N-methylamino)methyl)pyridine Dihydrochloride. The resultant compound of Example 36B (3.05 g, 13.7 mmol) was treated with 30 ml of 4N HCl in dioxane and heated at 40°C for 0.5 h. The solvent was removed in vacuo to provide the crude desired compound as a light brown solid. D. N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valine Methyl Ester. A mixture of 1.61 g (7.2 mmol) of the resultant compound of Example 36C and 1.14 g (7.2 mmol) of the resultant compound of Example 14A in 40 ml of dichloromethane was treated with 2 ml (18 mmol) of 4-methylmorpholine. After being stirred for 2 h, the solution was partitioned between dichloromethane and water, dried over Na 2 SO 4 , and concentrated. Chromatography on silica gel using 2% methanol in chloroform provided 1.94 g (96%) of the desired compound (R f 0.32, 5% methanol in chloroform) as a colorless oil. 1 H NMR (CCDl 3 ) δ 0.93 (d, J = 7 Hz, 3 H), 0.97 (d, J = 7 Hz, 3 H), 2.16 (m, 1 H), 3.03 (s, 3 H), 3.72 (s, 3 H), 4.43 (dd, J = 8, 5 Hz, 1 H), 4.55 (s, 2 H), 6.15 (br, 1 H), 7.22 (dd, J = 8, 6 Hz, 1 H), 7.28 (d, J = 6 Hz, 1 H), 7.69 (br t, 1 H), 8.55 (d, J = 5 Hz, 1 H). E. N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valine p-Nitrophenyl Ester. Using the procedures of Example 25A and Example 33A but replacing the resultant compound of Example 16A with the resultant compound of Example 36D provided the desired compound. F. (2S,3R,4R,5S)-2,5-Di-(N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 33A with the resultant compound of Example 36E provided, after silica gel chromatography using a gradient of 2-5% methanol in chloroform, the desired compound (R f 0.28, 5% methanol in chloroform) as a white solid, m.p. 108-111°C, in 85% yield. Mass spectrum: (M + H) + = 795. Anal. Calcd for C 44 H 58 N 8 O 6 ·1.25H 2 O: C, 64.65; H, 7.46; N, 13.71. Found: C, 64.35; H, 7.06; N, 13.58. Example 37 (2S,3S,4S,5S)-2,5-Di-(N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 33A with the resultant compound of Example 36E and replacing the resultant compound of Example 21 with (2S,3S,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided, after silica gel chromatography using a gradient of 1-5% methanol in chloroform, the desired compound (R f 0.38, 5% methanol in chloroform) as a white solid, m.p. 110-112°C, in 75% yield. Mass spectrum: (M + H) + = 795. Anal. Calcd for C 44 H 58 N 8 O 6 ·H 2 O: C, 65.00; H, 7.44; N, 13.78. Found: C, 64.61; H, 7.21; N, 13.60. Example 38 (2S,3R,4S,5S)-2,5-Di-(N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 33A with the resultant compound of Example 36E and replacing the resultant compound of Example 21 with (2S,3R,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided, after silica gel chromatography using a gradient of 1-2% methanol in chloroform, the desired compound (R f 0.36, 5% methanol in chloroform) as a white solid, m.p. 159-162°C, in 79% yield. Mass spectrum: (M + H) + =795. Anal. Calcd for C 44 H 58 N 6 O 8 : C, 66.48; H, 7.35; N, 14.09. Found: C, 66.31; H, 7.43; N, 13.95. Example 39 2,4-Di-(N-((N-Methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. The resultant compound of Example 36D was hydrolyzed according to the procedure of Example 25A and coupled to the resultant compound of Example 4 according to the carbodiimide coupling procedure described in Example 7 to provide, after silica gel chromatography using 3% methanol in chloroform, the desired compound (53%, R f 0.5, 10% methanol in chloroform) as a white solid, m.p. 70-72°C. Mass spectrum: (M + H) + = 765. Example 40 A. N-((4-Pyridinyl)methoxycarbonyl)-valine p-Nitrophenyl Ester. Using the procedures of Example 25A and Example 33A but replacing the resultant compound of Example 16A with the resultant compound of Example 14B provided the desired compound. B. (2S,3R,4R,5S)-2,5-Di-(N-((4-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 33A with the resultant compound of Example 40A provided, after silica gel chromatography using a gradient of 2-5% methanol in chloroform, the desired compound (R f 0.11, 10% methanol in chloroform) as a white solid, m.p. 221-224°C in 48% yield. Mass spectrum: (M + H) + = 769. Anal. Calcd for C 42 H 52 N 6 O 8 ·0.5H 2 O: C, 64.85; H, 6.87; N, 10.80. Found: C, 64.91; H, 6.81; N, 10.80. Example 41 (2S,3R,4S,5S)-2,5-Di-(N-(t-butylaminocarbonyl)amino)-3,4-dihydroxy-1,6-diphenylhexane. A solution of 30 mg (0.1 mmol) of (2S,3R,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane in 1 ml of dichloromethane was treated with 25µl (0.22 mmol) of t-butylisocyanate. The resulting solution was stirred at ambient temperature, diluted with dichloromethane, washed with brine, dried over Na 2 SO 4 , and concentrated in vacuo. Silica gel chromatography using a gradient of 1-3% methanol in chloroform provided 49 mg (98%) of the desired compound (R f 0.4, 10% methanol in chloroform) as a white solid, m.p. 193-196°C. Mass spectrum: (M + H) + = 499. Anal. Calcd for C 20 H 42 N 4 O 4 ·H 2 O: C, 65.09; H, 8.58; N, 10.84. Found: C, 65.17; H, 8.21; N, 10.77. Example 42 (2S,3S,4S,5S)-2,5-Di-(N-((4-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 33A with the resultant compound of Example 40A and replacing the resultant compound of Example 21 with (2S,3S,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided, after silica gel chromatography using a gradient of 2-5% methanol in chloroform, the desired compound (35%, R f 0.25, 10% methanol in chloroform) as a white solid, m.p. 190-193°C. Mass spectrum: (M + H) + = 769. Example 43 A. N-((3-Pyridinyl)methoxycarbonyl)-valine p-Nitrophenyl Ester. Using the procedures of Example 25A and Example 33A but replacing the resultant compound of Example 16A with the resultant compound of Example 15A provided the desired compound. B. (2S,3S,4S,5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 33A with the resultant compound of Example 43A and replacing the resultant compound of Example 21 with (2S,3S,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided, after silica gel chromatography using a gradient of 5-10% methanol in chloroform, the desired compound (R f 0.31, 10% methanol in chloroform) as a white solid, m.p. 202-207°C. Mass spectrum: (M + H) + = 769. Example 44 (2S,3R,4S,5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3-4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 33B but replacing the resultant compound of Example 33A with the resultant compound of Example 43A and replacing the resultant compound of Example 21 with (2S,3R,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane provided, after silica gel chromatography using a gradient of 2-5% methanol in chloroform, the desired compound (31%, R f 0.28, 10% methanol in chloroform) as a white solid, m.p. 212-216°C. Mass spectrum: (M + H) + = 769. Example 45 2,4-Di-(N-((2-(4-morpholinyl)ethyloxy)carbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. The resultant compound of Example 17B was coupled to the resultant compound of Example 4 using the carbodiimide coupling procedure of Example 14D to provide, after silica gel chromatography using 3% methanol in chloroform, the desired compound (R f 0.6, 10% methanol in chloroform) in 66% yield as a white solid, m.p. 122-123°C. Mass spectrum: (M + H) + = 783. Example 46 2-(Boc-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Boc-valine was coupled to the resultant compound of Example 9 using the carbodiimide coupling procedure of Example 7 to provide, after silica gel chromatography using 3% methanol in chloroform, the desired compound (82%, R f 0.7, 10% methanol in chloroform) as a white solid, m.p. 184-184°C. Mass spectrum: (M + H) + = 703. Anal. Calcd for C 40 H 54 N 4 O 7 ·0.5H 2 O: C, 67.49; H, 7.79; N, 7.87. Found: C, 67.79; H, 7.63; N, 7.91. Example 47 4-(Cbz-valinyl-amino)-2-(valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 4 with the resultant compound of Example 46 provided a crude hydrochloride salt which was partitioned between chloroform and aqueous NaHCO 3 , dried over Na 2 SO 4 , and concentrated. Chromatography of the residue on silica gel using 3% methanol in chloroform provided in 89% yield the desired compound (R f 0.5, 10% methanol in chloroform) as a white solid, m.p. 126-127°C. Mass spectrum: (M + H) + = 603. Anal. Calcd for C 35 H 46 N 4 O 5 ·1.5H 2 O: C, 66.75; H, 7.84; N, 8.90. Found: C, 66.88; H, 7.25; N, 8.79. Example 48 A. N-((2-Thiazolyl)methoxycarbonyl)-valine Methyl Ester. Using the procedure of Example 14B but replacing pyridine-4-methanol with 2-(hydroxymethyl)thiazole (Dondoni, et. al., Synthesis , 1987 , 998; Tetrahedron Lett . 1983 , 24 , 2901) provided, after silica gel chromatography using 3% methanol in chloroform, the desired compound in 74% yield. Mass spectrum: (M + H) + =273. B. 2,4-Di-(N-((2-thiazolyl)methoxycarbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. The resultant compound of Example 48A was hydrolyzed according to the procedure of Example 25A and coupled to the resultant compound of Example 4 according to the carbodiimide coupling procedure of Example 7 to provide, after silica gel chromatography using 3% methanol in chloroform, the desired compound (72%, R f 0.7, 10% methanol in chloroform) as a white solid, m.p. 92-93°C. Mass spectrum: (M + H) + =751. Anal, Calcd for C 37 H 46 N 6 O 7 S: C, 59.18; H, 6.18; N, 11.20. Found: C, 60.42; H, 6.51; N, 10.61. Example 49 4-(Cbz-valinyl-amino)-2-(N-((N-((3-pyridinyl)methyl)amino)-carbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. A solution of 3-(aminomethyl)pyridine (12 µl, 0.11 mmol) in 0.5 ml of nitromethane was cooled to -20°C and treated with 0.23 ml (0.12 mmol) of a 0.5 M solution of carbonyl bis(N-methyl)imidazole triflate (Rappoport, et. al., J. Am. Chem. Soc . 1989 , 111 , 6856) in nitromethane. After 30 min, the solution was treated with a solution of 50 mg (0.08 mmol) of the resultant compound of Example 47 in 1.0 ml of dimethylformamide and 26 µL (0.24 mmol) of 4-methylmorpholine. The resulting solution was stirred at 0°C for 1 h, concentrated in vacuo, partitioned between chloroform and aqueous NaHCO 3 , dried over Na 2 SO 4 , and concentrated. The residue was purified by silica gel chromatography using 3% methanol in chloroform to provide 40 mg (65 %) of the desired compound (R f 0.4, 10% methanol in chloroform) as a white solid, m.p. 205-206°C. Mass spectrum: (M + H) + =737. Example 50 (2S,3R,4R,5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. Using the procedure of Example 14D the resultant compound of Example 15B was coupled to the resultant compound of Example 21 to provide, after silica gel chromatography using 5% methanol in chloroform, the desired compound (R f 0.25, 10% methanol in chloroform) as a white solid, m.p. 207-208°C, in 32% yield. Mass spectrum: (M + H) + = 769. Anal. Calcd for C 42 H 52 N 6 O 8 ·1.25H 2 O: C, 63.74; H, 6.94; N, 10.62. Found: C, 63.70; H, 6.70; N, 10.54. Example 51 (2S,3R,4S,5S)-2,5-Di-(N-((2-(4-morpholinyl)ethyloxy)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane. The resultant compound of Example 17B was coupled to the resultant compound of Example 21 using the carbodiimide coupling procedure of Example 14D to provide, after silica gel chromatography using 5% methanol in chloroform, the desired compound (R f 0.21, 10% methanol in chloroform) as a white solid, m.p. 227-230°C (dec) in 47% yield. Mass spectrum: (M + H) + = 813. Anal. Calcd for C 42 H 64 N 6 O 10 ·1.25H 2 O: C, 60.38; H, 8.02; N, 10.06. Found: C, 60.21; H, 7.78; N, 10.43. Example 52 2-(N-(((1-Methyl)piperidin-3-yl)methoxycarbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedures of Example 17 but replacing 4-(2-hydroxyethyl)morpholine with 3-(hydroxymethyl)-1-methylpiperidine provided the desired compound (R f 0.30, 10% methanol in chloroform) as a white solid, m.p. 162-163. Mass spectrum: (M + H) + = 758. Anal. Calcd for C 43 H 59 N 5 O 7 ·0.5H 2 O: C, 67.34; H, 7.88; N, 9.13. Found: C, 67.40; H, 8.03; N, 8.69. Example 53 2-(N-(((1-Methyl)piperidin-2-yl)methoxycarbonyl)-valinyl-amino)-4-(Cbz-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedures of Example 17 but replacing 4-(2-hydroxyethyl)morpholine with 2-(hydroxymethyl)-1-methylpiperidine provided the desired compound (R f 0.40, 10% methanol in chloroform) as a white solid, m.p. 160-161. Mass spectrum: (M + H) + = 758. Anal. Calcd for C 43 H 59 N 5 O 7 ·0.5H 2 O: C, 67.34; H, 7.88; N, 9.13. Found: C, 67.15; H, 7.77; N, 8.91. Example 54 2,4-Di-(N-((N-benzylamino)carbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 41 but replacing (2S,3R,4S,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane with the resultant compound of Example 12 and replacing t-butylisocyanate with benzylisocyanate provided, after silica gel chromatography using 3% methanol in chloroform, the desired compound (64%, R f 0.7, 10% methanol in chloroform) as a white solid, m.p. 238-238.5°C. Mass spectrum: (M + H) + =735 Example 55 2,4-Di-(N-((N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. A solution of 34 mg of triphosgene in 2 ml of tetrahydrofuran was cooled under N 2 atmosphere to -78°C and treated over a period of 2 min with a precooled (-78°C) solution of 80 mg of the resultant compound of Example 140 and 40 µl of 4-methylmorpholine in 1 ml of tetrahydrofuran. After 30 min, the solution was treated with a solution of 37 mg of 2-(aminomethyl)pyridine and 40 µl of 4-methylmorpholine in 1 ml of tetrahydrofuran. The resulting solution was allowed to warm to -10°C over a 2 hour period, after which it was concentrated in vacuo. Silica gel chromatography of the residue using a gradient of 3% methanol in chloroform-4.5% methanol/4.5% isopropylamine in chloroform provided 80 mg (64%) of the desired compound (R f 0.46, 4.5% methanol/4% isopropylamine in chloroform) as a white solid, m.p. 198-199°C. Mass spectrum: (M + H) + = 737. Example 56 2,4-Di-(N-((N-((3-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-1,5-diphenyl-3-hydroxypentane. Using the procedure of Example 55 but replacing 2-(aminomethyl)pyridine with 3-(aminomethyl)pyridine provided, after silica gel chromatography using a gradient of 3% methanol in chloroform-4.5% methanol/4.5% isopropylamine in chloroform a 60% yield of the desired compound (R f 0.3, 4.5% methanol/4% isopropylamine in chloroform) as a white solid, m.p. 238-239°C. Mass spectrum: (M + H) + = 737. Anal. Calcd for C 42 H 52 N 6 O 6 ·H 2 O: C, 66.82; H, 7.21; N, 11.13. Found: C, 67.07; H, 6.98; N, 11.12. Example 57 A. 2-Oxazolidinone derivative of Ethyl 4(S)-amino-5-phenyl-2,2-difluoro-3(R)-hydroxypentanoate. Using the procedure described in Examples 26A and 26B but replacing Boc-L-cyclohexylalaninal with phenylalaninal provided the desired product. Mass spectrum: M + = 299. B. 4(S)Benzyl-5(R)-(3'(3',3'-difluoro-2'-oxo-1'-phenyl-propyl))-2-oxazolidinone. The hydrolysis of the resultant compound of Example 57A by lithium hydroxide in aqueous dioxane provided the corresponding acid, which was condensed with N,O-dimethyl-hydroxylamine with EDAC to give the corresponding amide. The amide was dissolved in THF and reacted with 3 equivalents of benzylmagnesium chloride to give the desired compound (88%). Mass spectrum: M + = 345. 1 H NMR (CDCl 3 ) δ2.82 (dd, 1H), 3.0 (dd, 1H), 4.07 (m, 2H), 4.15 (m, 1H), 4.70 (m, 1H), 7.15-7.38 (m, 10H). C. 2,5-Diamino-1,6-diphenyl-3,3-difluoro-4-hydroxyhexane. Using the resultant compound from Example 57B and the procedures described in Example 26D, 26E, and 26F provided the desired compound. Mass spectrum: M + = 320. Example 58 2,5-Bis-(Cbz-valinyl-amino)-1,6-diphenyl-3,3-difluoro-4-hydroxyhexane. Using the resultant compound from Example 57C and the procedure described in Example 27, the desired product was obtained in 70% yield. Mass spectrum: (M+H) + = 787. 1 H NMR (CDCl 3 ) δ0.60-0.80 (m, 12H), 5.02 (s, 4H), 6.05 (br d, 1H), 6.95, 1H), 7.10-7.35 (m, 10H), 7.50 (br d, 1H), 7.95 (br d, 1H). Example 59 2,5-Bis-(2-pyridyl-methoxycarbonyl-valinyl-amino)-1,6-diphenyl-3,3-difluoro-4-hydroxyhexane. Using the resultant compound from Example 57C and the procedure described in Example 27, but replacing Cbz-Val with 2-pyridinyl-methoxycarbonyl-valine provided the desired compound in 74% yield. (M+H) + = 789, 1 H NMR (CDCl 3 ) δ0.60-0.75 (m, 12H), 1.75 (m, 1H), 1.88 (m, 1H), 3.80 (m, 2H), 4.62 (m, 1H), 4.80 (m, 1H), 5.08 (s, 2H), 5.10 (s, 2H), 6.10 (br d, 1H), 7.05-7.40 (m, 15H), 7.50 (br d, 1H), 7.80 (m, 2H), 8.0 (br d, 1H), 8.52 (m, 2H). Example 60 A. (6S,7R,8R,9S)-6,9-Di-((N-toluenesulfonyl)amino)-7,8-O-isopropylidenetetradecanediol To a solution of 1.175 g (5.715 mmol) of cuprous bromide-dimethylsufide complex in 8 mL of anhydrous, oxygen-free THF at -40°C was added 4.57 mL (11.43 mmol) of 2.5 M n-butyl lithium. The solution was stirred for 0.5 h at -40°C and then cooled to -60°C. A solution of (2S,3R,4R,5S)-1,2:5,6-diimino-3,4-O-isopropylidenehexanediol (703 mg, 1.43 mmol(Y.L. Merrer, et al, Heterocycles , 1987 , 25, 541-548)) in ∼16 mL of anhydrous, oxygen-free THF was added. The solution was allowed to warm slowly to approximately -25°C and stirred for 4 h at that temperature. The reaction mixture was treated with 10% concentrated ammonium hydroxide in saturated ammonium chloride solution and the aqueous mixture was extracted with diethyl ether. The organic solution was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography on a 1.0 X 27 cm silica gel column eluted with 20% ethyl acetate in hexane to give 0.414 g (47.6% yield) of the title compound; DCI/NH 3 MS M/Z: 626 (M+NH 4 ) + ; The 300 MHz 1 H NMR spectrum was consistent with the assigned structure. B. N,N-Bis-(Cbz-valinyl)-(2S, 3R, 4R, 5S)-6,9-diamino-7,8-O-isopropylidenetetradecanediol The resultant compound of Example 60A, in 3 mL of anhydrous diethyl ether was added to ∼75 mL of liquid ammonia and small pieces of sodium metal were added until a blue color persisted for 5 minutes. The reaction was quenched with ammonium chloride and the ammonia was evaporated. The residue was dissolved in diethyl ether and the ether solution was washed with dilute aqueous ammonium hydroxide and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the intermediate 6,9-diamino compound. The diamine (159 mg, 0.53 mmol) was dissolved in 5 mL of THF and the THF solution was cooled in an ice bath. To the cooled solution was added 532 mg (2.12 mmol) of N-carbobenzyloxyvaline, followed by 406 mg (2.12 mmol) of N-ethyl-N'-(dimethylaminopropyl)carbodiimide and 295 µL (2.12 mmol) of triethylamine. The reaction mixture was allowed to gradually warm to ambient temperature and was stirred at ambient temperature overnight. The solvent which had evaporated from the reaction mixture was replaced with 5 mL of THF and the mixture was stirred for 2 h. The reaction mixture was then diluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a 1.5 X 35 cm silica gel column eluted with 30% ethyl acetate to to give 83 mg (20% yield) of the title compound; DCI/NH 3 MS M/Z: 784 (M+NH 4 ) + , 767 (M+H) + ; The 300 MHz 1 H NMR spectrum is consistent with the assigned structure. Analysis calculated for C 43 H 66 N 4 O 8 : C, 67.36; H, 8.62; N, 7.31. Found: C, 67.68; H, 9.02; N, 7.27. C. N,N-Bis-(Cbz-valinyl)-(6S, 7R, 8R, 9S)-6,9-diamino-7,8-tetradecanediol A solution of the resultant compound of Example 60B (80 mg, 0.1 mmol) in 3.0 mL of trifluoroacetic acid containing 0.3 mL of water was stirred at 0°C for 4.75 h. The solvent was evaporated under reduced pressure. The residue was purified by flash chromatography on a 1.0 X 22 cm silica gel column eluted with 50% ethyl acetate in hexane to give 51 mg (45% yield) of the title compound; 1 H NMR (CDCl 3 ) δ 0.86 (t, 6H), 0.92 (d, 6H), 0.98 (d, 6H), 1.20-1.33 (br m, 12H), 1.51-1.61 (br m, 2H), 2.12-2.22 (m, 2H), 3.39 (br s, 1H), 3.55 (br s, 1H), 3.82-3.92 (m, 2H), 3.95 (dd, 2H), 5.10 (s, 4H), 5.10 (s, 4H), 5.20 (br d, 2H), 6.23 (d, 2H), 7.30-7.40 (m, 10H).Analysis calculated for C 40 H 62 N 4 O 8 : C, 66.12; H, 8.54; N, 7.71. Found: C, 66.04; H, 8.59; N, 7.70. Example 61 A. (2S,3R,4R,5S)-1,6-Diphenyl-2,5-di-((N-toluenesulfonyl)amino)-3,4-O-isopropylidenehexanediol To a stirred suspension of 411 mg (2.0 mmol) of CuBr-Me 2 S in 2 mL of ether at 0 °C was added 3.08 ml (4.0 mmol) of 1.3 M phenyllithium in ether/cyclohexane. After 30 minutes, a suspension of 246 mg (0.50 mmol) of (2S,3R,4R,5S)-1,2:5,6-diimino-3,4-O-isopropylidenehexanediol (703 mg, 1.43 mmol (Y.L. Merrer, et al, Heterocycles , 1987 , 25 , 541-548)) was added in 20 mL. After 80 minutes, the reaction mixture was quenched with 10% NH 4 OH saturated with NH 4 Cl. The ether layer was washed with brine, dried over magnesium sulfate, and concentrated under reduced pressure. Chromatography of the residue on silica gel with 7:3/hexane:EtOAc afforded 280 mg (86.4%) of the title compound. MS m/z 649 (M+H + ) B. N,N-Bis-(Cbz-valinyl)-(2S, 3R, 4R, 5S)-1,6-diphenyl-2,5-diamino-3,4-hexanediol The resultant compound of Example 61A was converted to the title compound in a manner analogous to that described in Examples 60B and 60C. Example 62 A. N,N-Bis-(Cbz-valinyl)-(2S, 3R, 4R, 5S)-1,6-di-(4-(methoxymethyloxy)phenyl)-2-5-diamino-3-4-hexanediol. Using the procedures of Example 61, but subsituting 4-(methoxymethyloxy)phenyllithium for phenyllithium in Step A provided the desired product. B. N,N-Bis-(Cbz-valinyl)-(2S, 3R, 4R, 5S)-1,6-di-(4-hydroxyphenyl)-2-5-diamino-3,4-hexanediol. The resultant compound of Example 62A was hydrolyzed according to the procedure of Example 5B to provide the desired compound. Example 63 2,4-Bis-(N-(Cbz-isoleucyl)amino)-1,5-diphenyl-3-hydroxypentane The resultant compound of Example 4 (100 mg, 0.37 mmol), N-benzyloxycarbonyl-isoleucine p-nitrophenyl ester (428 mg, 1.1 mmol) and triethylamine (210 µL) were combined with 0.5 mL of dry acetonitrile and stirred together at ambient temperature for 0.5 h. Dry THF (1.0 mL) was added and the resultant solution was stirred at ambient temperature overnight. The reaction mixture was then diluted with 5 mL, of THF and 5 mL of 3 M aqueous sodium hydroxide solution was added. The mixture was stirred at ambient temperature for 0.5 h and then it was extracted with 100 mL of methylene chloride. The organic solution was washed with 3 X 25 mL of 0.5 M aqueous sodium hydroxide solution and brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue (319 mg) was dissolved in approximately 5 mL of chloroform and applied to a 1.0 X 40 cm column of 40 mesh silica gel. The column was eluted sequentially @ 5 p.s.i with 100 mL of chloroform, 100 mL of 0.5% methanol in chloroform and 100 mL of 1% methanol in chloroform to give 106 mg (37% yield) of the title compound: FAB MS M/Z: 765 (M+H) + . The 300 MHz 1 H NMR spectrum was consistent with the assigned structure. Analysis calculated for C 45 H 56 N 4 O 7 : C, 70.65; H, 7.38; N, 7.32. Found: C, 70.35; H, 7.52; N, 7.21. Example 64 N,N'-Bis-(1'-benzyloxycarbonyl-2'-methyl-1'-propyl)-3,4-dihydroxy-2,5-bis(phenylmethyl)adipamide. A solution of 100 mg (0.68 mmol) of 2,3:4,5-dianhydro-D-iditol (R.S. Tipson, et al, Carbohydrate Research , 1968 , 7, 232-243) in 5 mL of dichloromethane and 1 mL of DMSO was added to a solution of 208 mg (1.64 mmol) of oxalyl chloride in 10 mL of dichloromethane which had been treated with 257 mg (3.28 mmol) of DMSO at -78 °C. After 15 minutes at this temperature 685 mg (6.8 mmol) of triethylamine was added and the resulting solution allowed to warm to room temperature. The resulting dialdehyde is purifed by chromatography on silica gel and then oxidized to dimethyl 2,3:4,5-diepoxyadipate according to the procedure of D.R. Williams, et al (Tetrahederon Letters, 1988, 5087-5090). The diepoxide is then treated with the cuprate reagent prepared from benzyl lithium and CuBr-Me 2 S or CuCN in an ethereal solvent such as tetrahydrofuran or diethyl ether, to affored dimethyl 3,4-dihydroxy-2,5-bis(phenylmethyl)adipate. The resulting diol is then protected as the bis(t-butyldiphenylsilyl) ether by treatment with t-butyldiphenylsilyl chloride in DMF in the presence of imidazole. Saponification of the diester with LiOH in aqueous THF, followed by acidification and coupling to valine benzyl ester in the manner described in Example 304, followed by deprotection with tetrabutylammmonium fluoride in THF affords the title compound. Example 65 N,N-Bis-(Cbz-valinyl)-(2S, 3S, 4S, 5S)-1,6-diphenyl-2,5-diamino-3,4-hexanediol Oxidation of of 2,3:4,5-dianhydro-D-iditol (R.S. Tipson, et al, Carbohydrate Research , 1968 , 7, 232-243) as described in Example 64, but substituting THF for the dichloromethane/DMSO mixture as solvent, affords a solution of the corresponding dialdehyde. This solution is then recooled to -78 °C, and treated with four equivalents (relative to the iditol) of phenylmagnesium bromide. The reaction mixture is then quenched with a pH 7 phosphate buffer and extracted into ethyl acetate, dried over sodium sulfate, and concentrated under reduced pressure. The resulting diol is treated with benzyl isocyanate, in the presence of either DMAP or diisopropylethylamine, in an inert solvent, such as benzene or THF. The resulting bis-carbamate is then treated with 2 equivalents of NaH or potassium t-butoxide in THF. The resulting diol is then treated with hydrogen over a Pd catalyst in a solvent such as MeOH to afford (2S, 3S, 4S, 5S)-3,4-dihydroxy-1,6-diphenyl-hexane-2,5-diamine. This is then converted into the title compound by treatment with Cbz-valine p-nitrophenyl ester in THF in the presence of triethylamine. Fluorogenic Assay for Screening Inhibitors of HIV Protease The inhibitory potency of the compounds of the invention can be determined by the following method. A compound of the invention is dissolved in DMSO and a small aliquot further diluted with DMSO to 100 times the final concentration desired for testing. The reaction is carried out in a 6 X 50 mm tube in a total volume of 300 microliters. The final concentrations of the components in the reaction buffer are: 125 mM sodium acetate, 1 M sodium chloride, 5 mM dithiothreitol, 0.5 mg/ml bovine serum albumin, 1.3 uM fluorogenic substrate, 2% (v/v) dimethylsulfoxide, pH 4.5. After addition of inhibitor, the reaction mixture is placed in the fluorometer cell holder and incubated at 30°C for several minutes. The reaction is initiated by the addition of a small aliquot of cold HIV protease. The fluorescence intensity (excitation 340 nM, emmision 490 nM) is recorded as a function of time. The reaction rate is determined for the first six to eight minutes. The observed rate is directly proportional to the moles of substrate cleaved per unit time. The percent inhibition is 100 X (1 - (rate in presence of inhibitor)/(rate in absence of inhibitor)) . Fluorogenic substrate: Dabcyl-Ser-Gln-Asp-Tyr-Pro-Ile-Val-Gln-EDANS wherein DABCYL = 4-(4-dimethylaminophenyl)azobenzoic acid and EDANS = 5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid. Compounds of the invention inhibit HIV-1 protease at concentrations between 0.01 nM and 500,000 nM. Table 3 shows the inhibitory potencies of specific compounds of the invention against HIV-1 protease. Compound of Example Percent Inhibition Inhibitor Concentration (micromolar) 10 75 0.01 14D 47 0.005 15C 59 0.005 16C 63 0.005 17C 40 0.005 18C 31 0.005 22B 74 0.001 31 56 0.001 32 65 0.001 33B 81 0.001 34 84 0.001 35 78 0.001 36F 45 0.001 37 68 0.001 38 62 0.001 39 53 0.05 40 74 0.005 42 44 0.002 43 78 0.001 44 69 0.001 45 35 0.1 48B 63 0.01 49 33 0.001 50 74 0.001 51 33 0.01 52 79 0.05 53 49 0.05 54 78 0.005 58 92 0.005 58 53 0.001 59 71 0.001 63 52 0.005 Antiviral Activity The anti-HIV activity of the compounds of the invention can be determined by the following method. A mixture of 0.1 ml (2 X 10 5 cells/ml) of H9 cells and 0.1 ml (100 infectious units) of HIV-1 3B was incubated on a shaker for 2 h at 37°C. The resulting culture was washed three times and resuspended into 2 ml of medium containing 10 ul of a compound of the invention in dimethylsulfoxide. The control culture was treated in an identical manner except no compound was added to the medium. Aliquots of culture supernatants were removed at 3 time points, usually 4, 7 and 10 days, and monitored for HIV-1 antigen EIA (HIVAG-1) (Paul, et al., J. Med. Virol., 22 357 (1987)). Cell viability was determined by trypan blue dye exclusion, and cells were refed with media containing compound (except for control wells which were refed with media only) at these time points. Per cent inhibition of HIV by the compound was determined by comparing HIV antigen levels in the supernatants of infected cells incubated with compound to supernatants from the control culture without compound. The IC 50 is the concentration of compound that gives 50% inhibition of HIV activity. The LD 50 is the concentration of compound at which 50% of the cells remain viable. Table 4 shows the inhibitory potencies of compounds of the invention against HIV-1 in H9 cells: Compound of Example IC 50 (micromolar) LD 50 (micromolar) 10 0.3-0.8 120 14D 0.3-0.8 15 15C 0.6-1.1 20 16C 0.6-1.0 25 17C 0.5-1.0 >100 18C 6.1-9.4 21 22B 0.12 11 23B 1.1-2.7 >100 24B 0.75-1.1 >100 31 0.015-0.027 60 32 0.05-0.07 >100 33B 0.10 >100 34 0.04-0.1 >100 36F 0.42 >100 37 0.05-0.1 >100 38 0.09-0.18 >100 40 0.27 >100 48B 2.4-5.0 75 49 0.5-1.0 >100 50 0.25 180 51 1.2-7.5 >100 59 0.11-0.22 25 Additionally a decrease in infectivity of HIV as a measure of anti-HIV activity of the compounds of the invention can be assessed as follows: After incubation of the culture containing a compound of the invention as descrived above for approximately 6 days (range: 4-10 days), an aliquot (0.1 ml) of the supernatant was withdrawn, 5-fold dilutions were made in media, and these dilutions were then incubated with fresh H9 cells (4 X 10 5 cells/ml) on a shaker for 2 hr at 37°C. The resulting cultures were washed three times, resuspended in 2 ml of medium with and without compound, and incubated and maintained as above. Production of virus in the culture supernatant was monitered at various time points using the Abbott HIV-1 antigen EIA. Loss of infectivity was determined by comparing HIV antigen end point dilutions of cultures with and without compound. In this manner, the compound of Example 10 reduced the HIV infectivity 25-fold. The compounds of the present invention can be used in the form of salts derived from inorganic or organic acids. These salts include but are not limited to the following: acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, cyclopentanepropionate, dodecylsulfate, ethanesulfonate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxy-ethanesulfonate, lactate, maleate, methanesulfonate, nicotinate, 2-naphthalenesulfonate, oxalate, pamoate, pectinate, persulfate, 3-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, tosylate, mesylate and undecanoate. Also, the basic nitrogen-containing groups can be quaternized with such agents as loweralkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides, and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides, and others. Water or oil-soluble or dispersible products are thereby obtained. Examples of acids which may be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, sulphuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid and citric acid. Other salts include salts with alkali metals or alkaline earth metals, such as sodium, potassium, calcium or magnesium or with Organic bases. The compounds of the present invention can also be used in the form of esters. Such esters are a hydroxyl-substituted compound of formula I which has been acylated with a blocked or unblocked amino acid residue, a phosphate function, a hemisuccinate residue or a benzoyl group which is substituted on the phenyl ring with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. Amino acid residues which can be used, are lysine and those wherein the amino acyl group is -C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. The amino acid esters of particular interest are glycine and lysine. These esters serve as pro-drugs of the compounds of the present invention and serve to increase the solubility of these substances in the gastrointestinal tract. These esters also serve to increase solubility for intravenous administration of the compounds. These pro-drugs are metabolized in vivo to provide the hydroxyl-substituted compound of formula I. The preparation of the pro-drug esters is carried out by reacting a hydroxyl-substituted compound of formula I with an activated amino acyl, phosphoryl, hemisuccinyl or substituted benzoyl derivative as defined above. The resulting product is then deprotected to provide the desired pro-drug ester. The compounds of the present invention are useful for the treatment or prophylaxis of diseases caused by retroviruses in mammals (especially humans) and are particularly useful for the treatment or prophylaxis of acquired immune deficiency syndrome or an HIV infection. Total daily dose administered to a host in single or divided doses may be in amounts, for example, from 0.001 to 10 mg/kg body weight daily and more usually 0.01 to 1 mg. Dosage unit compositions may contain such amounts of submultiples thereof to make up the daily dose. The amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration. It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, rate of excretion, drug combination, and the severity of the particular disease undergoing therapy. The compounds of the present invention may be administered orally, parenterally, by inhalation spray, by aerosols, rectally, or topically in dosage unit formulations containing conventional nontoxic pharmaceutically acceptable carriers, adjuvants, and vehicles as desired. Topical administration may also involve the use of sublingual dosage forms, transdermal administration such as transdermal patches or iontophoresis devices. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection, or infusion techniques. Injectable preparations, for example, sterile injectable aqueous or oleagenous suspensions may be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution or suspension in a nontoxic parenterally acceptable diluent or solvent, for example, as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables. Suppositories for rectal administration of the drug can be prepared by mixing the drug with a suitable nonirritating excipient such as cocoa butter and polyethylene glycols which are solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum and release the drug. Solid dosage forms for oral administration may include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound may be admixed with at least one inert diluent such as sucrose lactose or starch. Such dosage forms may also comprise, as is normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate. In the case of capsules, tablets, and pills, the dosage forms may also comprise buffering agents. Tablets and pills can additionally be prepared with enteric coatings. Liquid dosage forms for oral administration may include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixirs containing inert diluents commonly used in the art, such as water. Such compositions may also comprise adjuvants, such as wetting agents, emulsifying and suspending agents, and sweetening, flavoring, and perfuming agents. The present agents can also be administered in the form of liposomes. As is known in the art, liposomes are generally derived from phospholipids or other lipid substances. Liposomes are formed by mono- or multi-lamellar hydrated liquid crystals that are dispersed in an aqueous medium. Any non-toxic, physiologically acceptable and metabolizable lipid capable of forming liposomes can be used. The present compositions in liposome form can contain, in addition to a compound of the present invention, stabilizers, preservatives, excipients, and the like. The preferred lipids are the phospholipids and the phosphatidyl cholines (lecithins), both natural and synthetic. Methods to form liposomes are known in the art. See, for example, Prescott, Ed., Methods in Cell Biology , Volume XIV, Academic Press, New York, N.Y. (1976), p. 33 et seq. While the compounds of the invention can be administered as the sole active pharmaceutical agent, they can also be used in combination with one or more immunomodulators, antiviral agents, other antiinfective agents or vaccines. Other antiviral agents to be administered in combination with a compound of the present invention include AL-721, beta interferon, polymannoacetate, ganciclovir, dideoxycytidine, trisodium phosphonoformate, HPA-23, eflornithine, Peptide T, Reticulose (nucleophosphoprotein), zidovudine (AZT), ansamycin LM 427, trimetrexate, UA001, ribavirin, alpha interferon and acyclovir. Immunomodulators that can be administered in combination with a compound of the present invention include bropirimine, Ampligen, anti-human alpha interferon antibody, colony stimulating factor, CL246,738, Imreg-1, Imreg-2, diethyldithiocarbamate, interleukin-2, alpha-interferon, inosine pranobex, methionine enkephalin, muramyl-tripeptide, TP-5, erythropoietin, naltrexone and tumor necrosis factor. Other antiinfective agents that can be administered in combination with a compound of the present invention include pentamidine isethionate. Any of a variety of HIV or AIDS vaccines can be used in combination with a compound of the present invention. It will be understood that agents which can be combined with the compounds of the present invention for the treatment or prophylaxis of AIDS or an HIV infection are not limited to those listed above, but include in principle any agents useful for the treatment or prophylaxis of AIDS or an HIV infection. When administered as a combination, the therapeutic agents can be formulated as separate compositions which are given at the same time or different times, or the therapeutic agents can be given as a single composition. The foregoing is merely illustrative of the invention and is not intended to limit the invention to the disclosed compounds. Variations and changes which are obvious to one skilled in the art are intended to be within the scope and nature of the invention which are defined in the appended claims.

Claims: Claims for the following Contracting States : AT, BE, CH, LI, DE, DK, FR, GB, IT, LU, NL, SE A compound of the formula: wherein X is -CH(OR 201 )-, -CH(OR 201 )CH(OR 202 )-, -C(O)-C(R)(R')- or -CH(R'')-C(R)(R') wherein R 201 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl and R 10 O-R 11 O-alkyl wherein R 10 and R 11 are independently selected from loweralkyl and benzyl; R 202 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl thioalkoxyalkyl, benzylthioalkyl and R 12 O-R 13 O-alkyl wherein R 12 and R 13 are independently selected from loweralkyl and benzyl; R is halogen; R' is halogen; R'' is -NH 2 , -NH(loweralkyl) or -OR 206 wherein R 206 is hydrogen, loweralkyl or alkoxyalkyl or benzyloxyalkyl; R 3 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl; R 9 at each occurrence is independently selected from hydrogen and loweralkyl; and G is R 17 -R 800 -C(T)-E-CH(R 3' )-C(T)- wherein R 17 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl, R 800 at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)-, T is independently selected at each occurrence from O and S, E at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)- and R 3' at each occurrence is independently selected from loweralkyl; wherein aryl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide, or aryl may be tetrafluorophenyl or pentafluorophenyl; wherein heterocyclic independently at each occurrence may be unsubstituted or substituted with one or two substituents independently selected from hydroxy, halo, oxo, alkylimino, amino, alkylamino, dialkylamino, alkoxy, benzyloxy, polyalkoxy, haloalkyl, cycloalkyl, -COOH, -SO 3 H and loweralkyl, and nitrogen-containing heterocyclics can be N-protected; wherein cycloalkyl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide; wherein loweralkyl independently at each occurrence or an alkyl group independently at each occurrence as part of the radicals arylalkyl, alkylamino, alkoxy, thioalkoxy, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl, dialkylamino, haloalkyl and (heterocyclic)alkyl are straight or branched chain alkyl groups containing from 1 to 6 carbon atoms; wherein polyalkoxy is -OR 45 wherein R 45 is a straight or branched chain containing C n' -O-C n'' linkages wherein n' and n'' are independently selected from 1 to 3; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. A compound according to Claim 1 wherein X is -CH(OR 201 )CH(OR 202 )- wherein R 201 and R 202 are as defined in Claim 1. A compound according to Claim 1 selected from the group consisting of: (2S, 3R, 4R, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; 2,4-Di-(N-((2-pyridinyl)methoxycarbonyl-valinylamino)-1,5-diphenyl-3-hydroxypentane; and 2,5-Bis-(2-pyridyl-methoxycarbonylvalinylamino)-1,6-diphenyl-3,3-difiuoro-4-hydroxyhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. (2S, 3R, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring; wherein loweralkyl independently at each occurrence or an alkyl group independently at each occurrence as part of the radicals alkylamino, alkoxy, thioalkoxy, dialkylamino and haloalkyl are straight or branched chain alkyl groups containing from 1 to 6 carbon atoms; wherein heterocyclic may be unsubstituted or substituted with one or two substituents independently selected from hydroxy, halo, oxo, alkylimino, amino, alkylamino, dialkylamino, alkoxy, benzyloxy, polyalkoxy, haloalkyl, cycloalkyl, -COOH, -SO 3 H and loweralkyl, and nitrogen containing heterocylics can be N-protected; wherein polyalkoxy is -OR 45 wherein R 45 is a straight or branched chain containing C n' -O-C n'' linkages wherein n' and n'' are independently selected from 1 to 3; wherein cycloalkyl independently at each occurence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkcxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide. A pharmaceutical composition comprising a pharmaceutical carrier and a therapeutically effective amount of a compound of any one of Claims 1-4. A compound of any one of Claims 1-4 for use as an active therapeutic agent. The use of a compound of any one of Claims 1-4 in the preparation of a medicament suitable for use in treatment of an HIV infection. The use of a compound of any one of Claims 1-4 in the preparation of a medicament suitable for use for inhibiting HIV protease. A process for the preparation of a compound of Claim 1 comprising reacting a compound of the formula: with a compound of the formula G-OH, wherein G, X, R 3 and R 9 are as defined in Claim 1. Claims for the following Contracting State : ES A process for the preparation of a compound of the formula: wherein X is -CH(OR 201 )-, -CH(OR 201 )CH(OR 202 )-, -C(O)-C(R)(R')- or -CH(R'')-C(R)(R') wherein R 201 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl and R 10 O-R 11 O-alkyl wherein R 10 and R 11 are independently selected from loweralkyl and benzyl; R 202 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl thioalkoxyalkyl, benzylthioalkyl and R 12 O-R 13 O-alkyl wherein R 12 and R 13 are independently selected from loweralkyl and benzyl; R is halogen; R' is halogen; R'' is -NH 2 , -NH(loweralkyl) or -OR 206 wherein R 206 is hydrogen, loweralkyl or alkoxyalkyl or benzyloxyalkyl; R 3 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl; R 9 at each occurrence is independently selected from hydrogen and loweralkyl; and G is R 17 -R 800 -C(T)-E-CH(R 3' )-C(T)- wherein R 17 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl, R 800 at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)-, T is independently selected at each occurrence from O and S, E at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)- and R 3' at each occurrence is independently selected from loweralkyl; wherein aryl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide, or aryl may be tetrafluorophenyl or pentafluorophenyl; wherein heterocyclic independently at each occurrence may be unsubstituted or substituted with one or two substituents independently selected from hydroxy, halo, oxo, alkylimino, amino, alkylamino, dialkylamino, alkoxy, benzyloxy, polyalkoxy, haloalkyl, cycloalkyl, -COOH, -SO 3 H and loweralkyl, and nitrogen-containing heterocyclics can be N-protected; wherein cycloalkyl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide; wherein loweralkyl independently at each occurrence or an alkyl group independently at each occurrence as part of the radicals arylalkyl, alkylamino, alkoxy, thioalkoxy, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl, dialkylamino, haloalkyl and (heterocyclic)alkyl are straight or branched chain alkyl groups containing from 1 to 6 carbon atoms; wherein polyalkoxy is -OR 45 wherein R 45 is a straight or branched chain containing C n' -O-C n'' linkages wherein n' and n'' are independently selected from 1 to 3; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, said process comprising reacting a compound of the formula: with a compound of the formula G-OH, wherein G, X, R 3 and R 9 are as defined above. A process according to Claim 1 wherein said compound of the formula G-OH is in the form of an acid halide derivative or an activated ester derivative. A process according to Claim 1 wherein said reaction is carried out in the presence of a coupling reagent selected from the group comprising dicyclohexylcarbodiimide, 3-ethyl-3'-(dimethylamino)propylcarbodiimide and bis(2-oxo-3-diphenylphosphoryl azide. A process according to Claim 1 wherein X is - CH(OR 201 )CH(OR 202 )- wherein R 201 and R 202 are as defined in Claim 1. A process according to Claim 1 for preparing a compound selected from the group consisting of: (2S, 3R, 4R, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; 2,4-Di-(N-((2-pyridinyl)methoxycarbonyl-valinylamino)-1,5-diphenyl-3-hydroxypentane; and 2,5-Bis-(2-pyridyl-methoxycarbonylvalinylamino)-1,6-diphenyl-3,3-difluoro-4-hydroxyhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. A process according to Claim 1 for preparing the compound (2S, 3R, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. Claims for the following Contracting State : GR A process for the preparation of a compound of the formula: wherein X is -CH(OR 201 )-, -CH(OR 201 )CH(OR 202 )-, -C(O)-C(R)(R')- or -CH(R'')-C(R)(R') wherein R 201 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl and R 10 O-R 11 O-alkyl wherein R 10 and R 11 are independently selected from loweralkyl and benzyl; R 202 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl thioalkoxyalkyl, benzylthioalkyl and R 12 O-R 13 O-alkyl wherein R 12 and R 13 are independently selected from loweralkyl and benzyl; R is halogen; R' is halogen; R'' is -NH 2 , -NH(loweralkyl) or -OR 206 wherein R 206 is hydrogen, loweralkyl or alkoxyalkyl or benzyloxyalkyl; R 3 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl; R 9 at each occurrence is independently selected from hydrogen and loweralkyl; and G is R 17 -R 800 -C(T)-E-CH(R 3' )-C(T)- wherein R 17 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl, R 800 at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl), T is independently selected at each occurrence from O and S, E at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)- and R 3' at each occurrence is independently selected from loweralkyl; wherein aryl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide, or aryl may be tetrafluorophenyl or pentafluorophenyl; wherein heterocyclic independently at each occurrence may be unsubstituted or substituted with one or two substituents independently selected from hydroxy, halo, oxo, alkylimino, amino, alkylamino, dialkylamino, alkoxy, benzyloxy, polyalkoxy, haloalkyl, cycloalkyl, -COOH, -SO 3 H and loweralkyl, and nitrogen-containing heterocyclics can be N-protected; wherein cycloalkyl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide; wherein loweralkyl independently at each occurrence or an alkyl group independently at each occurrence as part of the radicals arylalkyl, alkylamino, alkoxy, thioalkoxy, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl, dialkylamino, haloalkyl and (heterocyclic)alkyl are straight or branched chain alkyl groups containing from 1 to 6 carbon atoms; wherein polyalkoxy is -OR 45 wherein R 45 is a straight or branched chain containing C n' -O-C n'' linkages wherein n' and n'' are independently selected from 1 to 3; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, said process comprising reacting a compound of the formula: with a compound of the formula G-OH, wherein G, X, R 3 and R 9 are as defined above. A process according to Claim 1 wherein said compound of the formula G-OH is in the form of an acid halide derivative or an activated ester derivative. A process according to Claim 1 wherein said reaction is carried out in the presence of a coupling reagent selected from the group comprising dicyclohexylcarbodiimide, 3-ethyl-3'-(dimethylamino)propylcarbodiimide and bis(2-oxo-3-diphenylphosphoryl azide. A process according to Claim 1 wherein X is -CH(OR 201 )CH(OR 202 )- wherein R 201 and R 202 are as defined in Claim 1. A process according to Claim 1 for preparing a compound selected from the group consisting of: (2S, 3R, 4R, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; 2,4-Di-(N-((2-pyridinyl)methoxycarbonyl-valinylamino)-1,5-diphenyl-3-hydroxypentane; and 2,5-Bis-(2-pyridyl-methoxycarbonylvalinylamino)-1,6-diphenyl-3,3-difluoro-4-hydroxyhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. A process according to Claim 1 for preparing the compound (2S, 3R, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. The use of a compound of the formula: wherein X is -CH(OR 201 )-, -CH(OR 201 )CH(OR 202 )-, -C(O)-C(R)(R')- or -CH(R'')-C(R)(R') wherein R 201 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl and R 10 O-R 11 O-alkyl wherein R 10 and R 11 are independently selected from loweralkyl and benzyl; R 202 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl thioalkoxyalkyl, benzylthioalkyl and R 12 O-R 13 O-alkyl wherein R 12 and R 13 are independently selected from loweralkyl and benzyl; R is halogen; R' is halogen; R'' is -NH 2 , -NH(loweralkyl) or -OR 206 wherein R 206 is hydrogen, loweralkyl or alkoxyalkyl or benzyloxyalkyl; R 3 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl; R 9 at each occurrence is independently selected from hydrogen and loweralkyl; and G is R 17 -R 800 -C(T)-E-CH(R 3' )-C(T)- wherein R 17 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl, R 800 at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)-, T is independently selected at each occurrence from O and S, E at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)- and R 3' at each occurrence is independently selected from loweralkyl; wherein aryl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide, or aryl may be tetrafluorophenyl or pentafluorophenyl; wherein heterocyclic independently at each occurrence may be unsubstituted or substituted with one or two substituents independently selected from hydroxy, halo, oxo, alkylimino, amino, alkylamino, dialkylamino, alkoxy, benzyloxy, polyalkoxy, haloalkyl, cycloalkyl, -COOH, -SO 3 H and loweralkyl, and nitrogen-containing heterocyclics can be N-protected; wherein cycloalkyl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide; wherein loweralkyl independently at each occurrence or an alkyl group independently at each occurrence as part of the radicals arylalkyl, alkylamino, alkoxy, thioalkoxy, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl, dialkylamino, haloalkyl and (heterocyclic)alkyl are straight or branched chain alkyl groups containing from 1 to 6 carbon atoms; wherein polyalkoxy is -OR 45 wherein R 45 is a straight or branched chain containing C n' -O-C n'' linkages wherein n' and n'' are independently selected from 1 to 3; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, in the preparation of a medicament suitable for use in treatment of an HIV infection. The use of a compound of the formula: wherein X is -CH(OR 201 )-, -CH(OR 201 )CH(OR 202 )-, -C(O)-C(R)(R')- or -CH(R'')-C(R)(R') wherein R 201 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyl, benzylthioalkyl and R 10 O-R 11 O-alkyl wherein R 10 and R 11 are independently selected from loweralkyl and benzyl; R 202 is selected from hydrogen, alkoxyalkyl, benzyloxyalkyl thioalkoxyalkyl, benzylthioalkyl and R 12 O-R 13 O-alkyl wherein R 12 and R 13 are independently selected from loweralkyl and benzyl; R is halogen; R' is halogen; R'' is -NH 2 , -NH(loweralkyl) or -OR 206 wherein R 206 is hydrogen, loweralkyl or alkoxyalkyl or benzyloxyalkyl; R 3 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl; R 9 at each occurrence is independently selected from hydrogen and loweralkyl; and G is R 17 -R 800 -C(T)-E-CH(R 3' )-C(T)- wherein R 17 at each occurrence is independently selected from (aryl)alkyl and (heterocyclic)alkyl, R 800 at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)-, T is independently selected at each occurrence from O and S, E at each occurrence is independently selected from 0, S, -NH- and -N(loweralkyl)- and R 3' at each occurrence is independently selected from loweralkyl; wherein aryl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide, or aryl may be tetrafluorophenyl or pentafluorophenyl; wherein heterocyclic independently at each occurrence may be unsubstituted or substituted with one or two substituents independently selected from hydroxy, halo, oxo, alkylimino, amino, alkylamino, dialkylamino, alkoxy, benzyloxy, polyalkoxy, haloalkyl, cycloalkyl, -COOH, -SO 3 H and loweralkyl, and nitrogen-containing heterocyclics can be N-protected; wherein cycloalkyl independently at each occurrence may be unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, haloalkyl, alkoxy, benzyloxy, thioalkoxy, benzylthio, amino, alkylamino, dialkylamino, hydroxy, halo, mercapto, nitro, carboxaldehyde, carboxy, carboalkoxy, benzyloxycarbonyl and carboxamide; wherein loweralkyl independently at each occurrence or an alkyl group independently at each occurrence as part of the radicals arylalkyl, alkylamino, alkoxy, thioalkoxy, alkoxyalkyl, benzyloxyalkyl, thioalkoxyalkyi, benzylthioalkyl, dialkylamino, haloalkyl and (heterocyclic)alkyl are straight or branched chain alkyl groups containing from 1 to 6 carbon atoms; wherein polyalkoxy is -OR 45 wherein R 45 is a straight or branched chain containing C n' -O-C n'' linkages wherein n' and n'' are independently selected from 1 to 3; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, in the preparation of a medicament suitable for use for inhibiting HIV protease. The use according to Claims 7 or 8 wherein X is -CH(OR 201 )CH(OR 202 )- wherein R 201 and R 202 are as defined in Claim 7 or 8. The use according to Claim 7 or 8 wherein said compound is selected from the group consisting of: (2S, 3R, 4R, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4R, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3S, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; (2S, 3R, 4S, 5S)-2,5-Di-(N-((3-pyridinyl)methoxycarbonyl)-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; 2,4-Di-(N-((2-pyridinyl)methoxycarbonyl-valinylamino)-1,5-diphenyl-3-hydroxypentane; and 2,5-Bis-(2-pyridyl-methoxycarbonylvalinylamino)-1,6-diphenyl-3,3-difluoro-4-hydroxyhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring. The use according to Claim 7 or 8 wherein said compound is (2S, 3R, 4S, 5S)-2,5-Di-(N-((N-methyl-N-((2-pyridinyl)methyl)amino)carbonyl-valinyl-amino)-3,4-dihydroxy-1,6-diphenylhexane; or a salt or ester thereof wherein the ester is a hydroxyl-substituted compound wherein the hydroxyl group is acylated with (a) -PO 3 H 2 , (b) -C(O)CH 2 CH 2 COOH, (c) a benzoyl group wherein the phenyl ring of the benzoyl group is substituted with -NR 800 R 800 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring, (d) -C(O)CH((CH 2 ) 4 NH 2 )NH 2 or(e)-C(O)CH 2 NR 800 R 801 wherein R 800 and R 801 are independently selected from hydrogen and loweralkyl or the group -NR 800 R 801 forms a nitrogen containing heterocyclic ring.

Inventors: CODACOVI LYNN M, ERICKSON JOHN W, KEMPF DALE J, NORBECK DANIEL W, PLATTNER JACOB J, SHAM HING LEUNG, CODACOVI, LYNN M., ERICKSON, JOHN W., KEMPF, DALE J., NORBECK, DANIEL W., PLATTNER, JACOB J., SHAM, HING LEUNG
Applicants: ABBOTT LAB, ABBOTT LABORATORIES
Application year: 1990
Main classification: C07D213
IPC codes: C07D521, C07C215, C07D215, C07C33, C07C43, C07D295, C07D213, A61K31, C07C237, C07C69, C07D207, C07C49, C07C251, C07C239, C07D277, C07C271, C07C381, C07D307, C07C275, C07D487, C07D305, C07D233, A61P31, C07C235, C07K5, C07D303, C07F9, C07D217, C07C233, C07C217, C07C311, C07D211, C07C317, C07C39, C07C31, C07C229, C07C323, C07D263, C07D239, C07C45, C07D231, C07C225, C07D209, C07C53, C07D279, C07C211, A61K38, C07D317, C07C247, A61P37, C07F7