New pyrazolyl acrylic acid derivatives, useful as systemic fungicides for plant and material protection

Abstract: A pyrazolyl acrylic acid derivative having plant fungicidal activity of formula (I): wherein: R₁ and R₂ are independently hydrogen or C₁ - C₅ alkyl; A is a group of the formula: wherein X is independently hydrogen; halogen, cyano; nitro; C₁ - C₁₀ alkyl, C₂ - C₁₁ alkenyl, C₁ - C₁₀ alkoxy, C₂ - C₁₁ alkenyloxy, C₂ - C₁₁ alkynyloxy, C₂ - C₁₁ alkylcarbonyl or C₂ - C₁₁ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl and C₁ - C₅ alkoxy; or C₇ - C₁₃ arylcarbonyl, C₄ - C₉ cycloalkylcarbonyloxy, C₇ - C₁₃ arylcarbonyloxy, C₆ = C₁₂ aryl, C₆ - C₁₂ aryloxy, C₂ - C₁₃ heteroaryl having 1 - 3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, C₂ - C₁₃ heteroaryloxy having 1 - 3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, C₇ - C₁₂ aralkyl or C₇ - C₁₂ aralkyloxy optionally substitutes with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁ - C₅ alkyl, and C₁ - C₅ alkoxy; m is 1 or 2; and n is a integer of 1 - 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached; and B is methoxycarbonyl or cyano.

Description: This invention provides new pyrazolyl acrylic acid derivatives, processes for producing said compounds, and intermediates useful in those processes. The present invention also provides agricultural/horticultural fungicides which contain the derivatives, as an active ingredient and are capable of controlling various phytopathogens. It has been recognized that a class of acrylic acid derivatives have biological activities including fungicidal activities. Among them, a compound of the formula: is described in European Patent Publication No. 178826, and compounds of the formula: are described in Japanese Patent Publications (kokai) Nos. 277652/1986 and 254669/1989, respectively. As will be hereinafter discussed, these existing compounds are not sufficient effective enough in terms of fungicidal and systemic activity as agricultural/horticultural fungicides. It has now been found that a class of pyrazolyl acrylic acid derivatives have a potent fungicidal activity as well as strong systemic activity. Thus, the present invention provides novel agriculturally- and horticulturally-useful pyrazolyl acrylic acid derivatives of formula (I): wherein: R₁ and R₂ are independently hydrogen or C₁ - C₅ alkyl; A is a group of formula: wherein X is independently hydrogen; halogen; cyano; nitro; C₁ - C₁₀ alkyl, C₂ - C₁₁ alkenyl, C₁ - C₁₀ alkoxy, C₂ - C₁₁ alkenyloxy, C₂ - C₁₁ alkynyloxy, C₂ - C₁₁ alkylcarbonyl or C₂ - C₁₁ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl and C₁ - C₅ alkoxy; or C₇ - C₁₃ arylcarbonyl, C₄ - C₉ cycloalkylcarbonyloxy, C₇ - C₁₃ arylcarbonyloxy, C₆ - C₁₂ aryl, C₆ - C₁₂ aryloxy, C₂ - C₁₃ heteroaryl having 1 - 3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, total number of atoms of said heteroaryl being 5 - 14, C₂ - C₁₃ heteroaryloxy having 1 - 3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, total number of atoms of said heteroaryloxy being 5 - 14, C₇ - C₁₂ aralkyl or C₇ - C₁₂ aralkyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁ - C₅ alkyl, and C₁ - C₅ alkoxy; m is 1 or 2; and n is a integer of 1 - 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached; and B is methoxycarbonyl or cyano. The present invention also provides fungicidal compositions comprising a compound of formula (I) and agriculturally-acceptable inert carrier therefor. For the purpose of the present invention, as disclosed and claimed herein, the following terms are defiend as below. In the definition of R₁ and R₂, the term "C₁ - C₅ alkyl" includes, for example, methyl, ethyl, n -propyl, isopropyl, n -butyl, t -butyl, n -pentyl, isopentyl, t -pentyl, neopentyl and 1-methylbutyl. R₁ is preferably hydrogen or C₁ - C₄ alkyl, more preferably methyl or ethyl, and R₂ is preferably hydrogen or C₁ - C₃ alkyl, more preferably methyl, ethyl or propyl. In the definition of X, the term "C₁ - C₁₀ alkyl" includes, for example, methyl, ethyl, n -propyl, isopropyl, n -butyl, t -butyl, n -pentyl, isopentyl, t -pentyl, neopentyl, 1-methylbutyl, 1,2-dimethylbutyl, hexyl, heptyl, octyl, nonyl and decyl; the term "C₂ - C₁₁ , alkenyl" includes, for example, vinyl, allyl, 1-propenyl, 2-butenyl, 1,3-butadienyl and 2-pentenyl; the term "C₁ - C₁₀ alkoxy" includes methoxy, ethoxy, propoxy, isopropoxy and n -butoxy; the term "C₂ - C₁₁ alkynyloxy" includes, for example, propargyloxy; the term "C₂ - C₁₁ alkylcarbonyl" includes, for example, acetyl, propionyl and butyryl; the term "C₇ - C₁₃ arylcarbonyl" includes, for example, benzoyl, toluoyl and naphthoyl; the term "C₂ - C₁₁ alkylcarbonyloxy" includes, for example, acetoxy, propionyloxy and butyryloxy; the term "C₄ - C₉ cycloalkylcarbonyloxy" includes, for example, cyclohexanecarbonyloxy; the term "C₇ - C₁₃ arylcarbonyloxy" includes, for example, benzoyloxy and torylcarbonyloxy; the term "C₆ - C₁₂ aryl" includes, for example, phenyl, toryl, xylyl and naphthyl; the term "C₆ - C₁₂ aryloxy" includes, for example, phenoxy, toryloxy and naphthyloxy; the term "C₂ - C₁₃ heteroaryl" includes, for example, thiazolyl, benzothiazolyl, pyridyl and pyrazolyl; the term "C₂ - C₁₃ heteroaryloxy" includes, for example, thiazolyloxy, benzothiazolyloxy and pyridyloxy; the term "C₇ - C₁₂ aralkyl" includes, for example, benzyl and phenethyl; the term "C₇ - C₁₂ aralkyloxy" includes, for example, benzyloxy and phenethyloxy; the term "halogen" includes fluorine, chlorine, bromine and iodine. X is preferably hydrogen; halogen; cyano; nitro; optionally substituted C₁ - C₄ alkyl, C₂ - C₃ alkenyl, C₁ - C₃ alkoxy, C₂ - C₃ alkenyloxy, C₂ - C₃ alkynyloxy, or C₂ - C₅ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, and trifluoromethyl; or phenyl, phenoxy, benzyl, benzyloxy, thiazolyl, thiazolyloxy, pyridyloxy, benzoyl, or benzothiazolyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁ - C₄ alkyl, and C₁ - C₅ alkoxy. More preferably, X is hydrogen, fluorine, chlorine, bromine, cyano, nitro, optionally substituted methyl, butyl, optionally substituted methoxy, optionally substituted ethoxy, optionally substituted propoxy, optionally substituted propenyloxy, propargyloxy, butylyloxy, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted benzyl, benzyloxy, thiazolyloxy, benzothiazolyloxy, optionally substituted pyridyloxy, or benzoyl. Preferred substituents for methyl, methoxy, ethoxy, propoxy and propenyloxy groups include fluorine and chlorine. Preferred substituents for phenyl, phenoxy, benzyl, and pyridyloxy include methyl, butyl, methoxy, fluorine, chlorine, nitro and trifluoromethyl. When adjacent X forms a fused ring together with the benzene ring or thiazol ring to which they are attached, the fused ring may be preferably 2,3-dihydrobenzofuran, chroman, naphthalene, fluorene, anthraquinone, or benzo-1,3-dioxole. Therefore, preferred compounds (I) are those of formula (I), as defined above, in which A is a group of formula: wherein X is independently hydrogen; halogen; cyano; nitro; C₁ - C₄ alkyl, C₂ - C₃ alkenyl, C₁ - C₃ alkoxy, C₂ - C₃ alkenyloxy, C₂ - C₃ alkynyloxy, or C₂ - C₅ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, and trifluoromethyl; or phenyl, phenoxy, benzyl, benzyloxy, thiazolyl, thiazolyloxy, pyridyloxy, benzoyl, or benzothiazolyloxy optionally substituted with one or more substuents selected from halogen, nitro, cyano, trifluoromethyl, C₁ - C₄ alkyl and C₁ - C₄ alkoxy; m is 1 or 2; and n is a integer of 1 - 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached, where the fused ring is selected from 2,3-dihydrobenzofuran, chroman, naphtalene, fluorene, anthraquinone or benzo-1,3-dioxole. All the compounds of the invention are novel and can be prepared according to the general process described below: wherein, R₁, R₂, A and B are as defined above, The required starting material of formula (III) can be readily synthesized using any of known methods described in litertures such as Tetrahedron Letters , No. 19, 1591-2 (1971). The ester of formula (IIa), one of the key compound as an intermediate in the process of the invention, can be prepared by reacting the compound (III) in the presence of a base in an inert solvent with the compound of formula : A-CH₂-hal wherein, A is as defined above, and hal is a leaving group such as halogen atom, toluenesulphonyloxy or methanesulphonyloxy group. Inert solvents which may be used include dimethylformamide, dimethylsulfoxide, toluene, tetrahydrofuran and diisopropyl ether. Bases which can be used include sodium hydride, potassium carbonate and sodium ethylate. The alcohol (IV) can be obtained by reducing ester (IIa) with a reducing agent such as lithium aluminium hydride, metal sodium or sodium borohydride, or with various hydrogenation catalysts. The alcohol (IV) is then halogenated with a haloganating agent such as hydrochloride, thionylchloride, phosphorus oxychloride or phosphorus tribromide, which is followed by substitution with cyanide such as sodium cyanide, potassium cyanide or trimethylsilylnitrile to give the nitrile (IIb), the intermediate of the invention. The reduction for obtaining the ester (IIa) from the alcohol (IV) can be carried out using any of known procedures described in literatures such as Organic Synthesis , Col. Vol. II, p.468; ibid, Col. Vol. II, p.325; ibid, Col. Vol. IV, p.834, or those analogous to them. The halogenation can be carried out using any of known methods described in literatures such as Organic Synthesis , Col. Vol. IV, p.576; ibid, Col. Vol. VI, p.169; Tetrahedron Letters , No. 10, p.901 - 904 (1978), or those analogous to them. The cyanogenation for obtaining the nitrile (IIb) from the alcohol (IV) can be carried out using any of known methods described in literatures such as Organic Synthesis , Col. Vol. I, p.107; Kagaku no Ryouiki Zokan , No. 125, p.155-175 (1980);, or those analogous to them. The nitrile (IIb) is converted, if desired, into methyl ester by reacting it with methanol and/or water in the presence of hydrochloric acid or sulfuric acid. The esterification can be carried out using any of known methods described in literatures such as J. Chem. Soc. , 2417 (1963); J. Org. Chem. , 23 (1958); Ber. , 105, 1778 (1972); and Organic Synthesis , Col. Vol. I, p.270, or those analogous to them. According to the process of the inveniton, the intermediate (IIb) is then reacted with methyl formate and a base in the presence or absence of an inert solvent to give a compound of formula (V) or its salt. The compound (V) or its salt, when reacted with a methylation reagent under basic conditions in the presence or absence of an inert solvent, gives the compound of the invention of formula (I). The above-mentioned reaction can be carried out at a temperature in the range of about -78 °C to the boiling point of the solvent to be used, preferably 0 to 150 °C. Inert solvents which may be used include aromatic hydrocarbons such as benzene, toluene, and the like; ethers such as diethyl ether, tetrahydrofuran, and the like; polar solvents such as dimethylformamide, dimethyl sulfoxide, water, and the like; alcohols such as methanol, and the like; or a mixture comprising two or more of them. Bases which may be used include tertiary amines such as N-methylmorpholine, triethylamine, and the like; aromatic bases such as pyridine, picoline, N,N-diethylaniline, and the like; alkaline metal hydroxides such as sodium hydroxide, and the like; alkaline metal hydrides such as sodium hydride, and the like; alkaline metal alcohlates such as sodium methylate, and the like; alkaline metal carbonates or alkaline metal hydrogen carbonate such as potassium carbonate or sodium hydrogen carbonate, and the like. Methylation reagents include methyl iodide, dimethyl sulfate, and the like. Alternatively, the compound (I) of the invention can be prepared according to the following reaciton scheme. wherein, R¹, R², A and B are as defined above. The required α-keto-ester derivative of formula (VI) can be readily synthesized using known procedures described, for instance, in Synth. Commun. , 11 , 943 (1981), or those analogous to them. The compound (VI) can be prepared by the reaction between a corresponding pyrazolyl-magnesium halide derivative or pyrazolyl-lithium derivative with dimethyl oxalate. Alternatively, the compound (VI) can be prepared by oxdizing an acetate derivative of the compound of formula (IIb) with an appropriate oxdizing agent such as selenium dioxide, and the like. The comound of formula (VI) can be converted into the comound of formula (I) through the Wittig Reaction using a corresponding Wittig reagent in an appropriate solvent. The Wittig reagents are available by any of known methods, for example, by reacting a base to triphenylphosphonium halide which can be prepared from methoxymethyl chloride by any of known procedures. Each reaction can be carried out at a temperature in the range of about -78 °C to the boiling point of the solvent to be used, preferably -20 to 150 °C. Bases which may be used include alkali metal-containing bases such as sodium hydride, metal sodium, sodium amide, sodium dimethylsulfonate, and the like; alkaline metal alcohlates such as sodium methylate, and the like; alkyl lithium such as lithium butylate, and the like; tertiary amines such as triethylamine, and the like. Solvents which may be used include ethers such as diethyl ether, tetrahydrofuran, and the like; polar solvents such as dimethylformamide, dimethyl sulfoxide, and the like. Thus, the present invention provides a process for preparing a compound of formula (I), as defined above, which process comprises the steps; (a) reacting a compound of the formula (IIb): wherein R₁, R₂, A and B are as previously defined, with methyl formate and a base; and (b) reacting the compound obtained in step (a) or its salt with a methylation reagent in the presence or absence of a base. The present invention further provides another process for preparing the compound of formula (I), which comprises reacting a compound of the formula (VI): wherein R₁, R₂, A and B are as previously defined, with a Wittig reagent in an appropriate solvent. The pyrazole derivatives (IIb) and (VI) are novel and useful intermediates in the process for preparing the compounds (I) of the invention. Thus, the present invention also provides the pyrazole derivatives of formula (II); wherein R₁, R₂ and A are as defined above, and E is ethoxycarbonyl or -CH₂-B where B is as defined above. All the compounds of formula (I) are novel and have been demonstrated to be agriculturally- and horticulturally-useful. The compounds of the invention possess outstanding characteristics essential for fungicides, that is, high activity in controlling phytopathogens and strong systemic activity. Main pathogens to be controlled are Pyricularia oryzae (rice blast), Rhizoctonia solani (sheath blight of rice), Puccinia recondita (leaf rusts of wheat), Botrytis cinerea (gray mold of vegetables or fruit-trees) and Phytophthora infestance (late blight of tomato and potato). Furthermore, the compounds (I) are low in toxicity to human being and linestock and fishes as well, so that they are extremely useful as an active ingredient for the plant fungicides. The active compound (I) can be used alone without any further treatments for the purpose of controlling diseases. However, it is preferably formulated into a composition of an appropriate form by known procedures using agriculturally-acceptable innert adjuvants so that the active ingredient can disperse effectively upon application. Examples of adjuvants to be used in the present compositions are solvents, carriers, fillers and surfactants. Appropriate forms of the fungicidal compositions are, for example, emulsifiable concentrates, wettable powders and dusts. Examples of suitable solvents include water; alcohols such as methanol, ethanol, ethylene glycol, and the like; ketons such as aceton, methyl ethyl keton and cyclohexanone; ethers such as diethyl ether, dioxane and cellosolve; aliphatic hydrocarbons such as kerosene and fuel oil; aromatic hydrocarbons such as benzene, toluene, xylene, solvent naphtha, methyl naphthalene; hydrocarbon halides such as dichloroethane, trichlorobenzene, carbon tetrachloride; acid amides such as dimethylformamide; esters such as ethyl acetate, butyl acetate, glycerol esters of fatty acids; nitriles such as acetonitrile. The solvents may be used alone or as a mixture comprising two or more of them. Examples of suitable fillers include clays such as kaolin, bentonite; talcs such as talc, pyrophyllite; mineral powders such as diatomaceous, oxides including white carbon; and powders derived from plants such as soybean powder, carboxymethyl cellulose (CMC). These fillers may be used alone or as a mixture comprising two or more of them. Surfactants serve as spreading agents, dispersing agents emulsifying agents or penetrating agents. Examples of surfactants include nonionic surfactants such as polyoxyethylene alkylallyl ether, polyoxyethylene sorbitan monolaurate; cationic surfactants such as alkyldimethylbenzylammonium chloride, alkylpyridinium chloride; anionic surfactants such as alkylbenzene sulfonate, lignosulfonate, higher alcohol sulfate; amphoteric surfactants such as alkyldimethyl betain, dodesylaminoethyl glycine. These surfactants can be used alone or as a mixture comprising two or more of them. When the compounds of the invention are used in the form of emulsion, the fungicidal comopsitions of the invention are usually concentrated formulations which are diluted with water before use to obtain an emulsion containing the active compound at a suitable concentration for application, for example, spray application. The concentrated emulsifiable formulations generally contain 5 to 80 parts, preferably 10 to 70 parts, of the active compounds of the invention, 10 to 90, preferably 20 to 80 parts, of solvent and 3 to 20, preferably 5 to 15 parts, of surfactants. When the compounds of the invention are used in the form of wettable powders, the composition of the invention can be formulated in a mixture which contain 5 to 80 parts, preferably 10 to 70 parts, of the active compound, 10 to 90 parts, preferably 20 to 80 parts, of fillers and 1 to 20 parts, preferably 3 to 15 parts, of surfactants. The wettable powders are also diluted with a solvent such as water before use to otain a suitable solution. When the compounds of the invention are used in the form of dusts, the formulations of the invention are prepared simply by intimately mixing 0.1 to 10 parts, preferably about 1 to about 5 parts, of the acitve compound with 90 to 99.9 parts, preferably 95 to 99 parts, of suitable fillers such as kaolin, bentonite, talc. The compositions of the invention may additionally contain other active substances such as another fungicides, insectides, acaricides, provided that they are no longer inhibitory to the fungicidal action of the compounds (I). As for the way of application of the fungicide of this invention, it can be effectively applied either by spraying or dusting to plants or by application to water surface. In case of stem-foliar spray, emulsifiable concentrated formulation or wettable powder of the invention is diluted with water so as to give a emulsion or solution containing 10 to 1000 ppm of active compounds. In general, the application rate of so prepared emulsions or solutions ranges from 0.5 to 50 L/are (i.e., 1 to 20 L/acre). The following examples further illustrate the compound of the invention and the process preparing the same. All the comopunds prepared in the examples were confirmed on the basis of elemental analysis, and IR and NMR spectroscopies. Example 1 Preparation of (E)-methyl 2-(4-benzyloxy-1,3-dimethylpyrazol-5-yl)-3-methoxyacrylate (compound No. 1 in the Table 1) To a 5 ml solution of ethyl 1,3-dimethyl-4-hydroxypyrazole-5-carboxylate (2 g, 11.6 mmol) in anhydrous dimethylformamide (hereinafter, referred to as DMF) was added sodium hydride (60 % dispersion in oil) (0.47 g, 11.8 mmol) under ice-cooling. Benzyl bromide (2 g, 11.7 mmol) was then added dropwise thereto, and the resulting mixture was stirred at room temperature for one hour and poured into water. The mixture was extracted with ethyl acetate. The extract was washed with water, and saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was chromatographed over silica gel (eluent; ethyl acetate/n-hexane = 1:4) to give ethyl 4-benzyloxy-1,3-dimethylpyrazol-5-carboxylate (2.5 g, 9.1 mmol, 78 %). NMR (90 MHz, CDCl₃) δ ppm: 1.35(3H,t), 2.05(3H,s), 4.05(3H,s), 4.40(2H,q), 5.0(3H,s),7.45(5H) To a 15 ml solution of ethyl 4-benzyloxy-1,3-dimethylpyrazol-5-carboxylate (2.5 g, 9.1 mmol) in anhydrous tetrahydrofuran (hereinafter, referred to as THF) was added lithium aluminium hydride (0.2 g, 5.3 mmol) under ice-cooling. After stirring at room temperature for one hour, the reaction mixture was poured into water. The mixture was extracted with ethyl acetate, and the extract was successively washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo. To the residue (2 g) was added toluene (5 ml and thionyl chloride (2 g) and the resulting mixture was heated under reflux for one hour, After low boiling substances were evaporated, the residue was combined with ethyl acetate. The mixture was successively washed with, water, aquaous sodium bicarbonate, water, and saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo. To a 5 ml solution of the residue in dimethyl sulfoxide (hereinafter, referred to as DMSO) was added sodium cyanide (0.43 g, 8.8 mmol) and the mixture was stirred at room temperature and left to stand overnight. The reaction mixture was poured into water. The fixture was extracted with ethyl acetate, and the extract was successively washed with water, and saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was chromatographed over silica gel (eluent; ethyl acetate/n-hexane = 1:2) to obtain (4-benzyloxy-1,3-dimethylpyrazol-5-yl) acetonitrile (1.6 g, 6.6 mmol, 73 %). NMR (90 MHz, CDCl₃) δ ppm: 2.2(3H,s), 3.35(3H,s), 3.8(3H,s), 4.9(2H,s), 7.42(5H) Concentrated sulfuric acid was added to a solution of methanol (9.5 ml) and water (0.5 ml) under ice-cooling, and (4-benzyloxy-1,3-dimethylpyrazol-5-yl)acetonitrile (1.6 g, 6.6 mmol) was added thereto and the resulting mixture was heated for 6 hours under reflux. It was then concentrated in vacuo to remove methanol. The residue was diluted with ethyl acetate, successively washed with water, aquaous sodium bicarbonate, water, and saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was chromatographed over silica gel (eluent; ethyl acetate/n-hexane = 1:2) to obtain methyl (4-benzyloxy-1,3-dimethyl-pyrazol-5-yl)acetate (0.6 g, 2.2 mmol, 33 %). NMR (90 MHz, CDCl₃) δ ppm: 2.15(3H,s), 3.5(3H,s), 3.7(3H,s), 4.88(2H,s), 7.42(5H) A solution of methyl (4-benzyloxy-1,3-dimethylpyrazol-5-yl)acetate (2.5 g, 9.1 mmol) and methyl formate (15 g, 250 mmol) in anhydrous DMF (10 ml) was added dropwise to a suspension of sodium hydride (60 % dispersion in oil) (0.55 g, 13.8 mmol) in anhydrous DMF (5 ml), while the temperature being maintained below 10 °C by cooling on ice. After stirring at room temperature for 2 hours, the low boiling substances were removed under reduced pressure. To the residue was added potassium carbonate (2.5 g, 18.1 mmol), dimethyl sulfate (2.3 g, 18.2 mmol), and DMF (5 ml) under ice-cooling. After stirring at room temperature for 3 hours, the mixture was distilled under reduced pressure to remove low boiling substances. The residue was diluted with ethyl acetate, successively washed with water, and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was chromatographed over silica gel (eluent; ethyl acetate/n-hexane = 1:1) to obtain (E)-methyl 2-(4-benzyloxy-1,3-dimethylpyrazol-5-yl)-3-methoxyacrylate (compound No. 1 in the Table 1) as a clear oil (2.1 g, 73 %). Corresponding compound in Z-form (compound No. 2 in the Table 1) was also produced by the above reaction and recovered from the column. According to the procedures described in the above Example 1, compounds No. 3-8 and 12-115 listed in the following Table 1 were prepared. Example 2 Preparation of (E)-methyl 2-{1,3-dimethyl-4-[1-(2-methylthiazol-4-yl)-methyloxy]pyrazol-5-yl}-3-methoxyacrylate (compound No. 9 in Table 1) To a suspension of methoxymethyltriphenylphosphonium chloride (2 g, 5.84 mmol) in anhydrous THF was added 3.5 ml solution of lithium n-butylate (1.6 mol) in hexane. After stirring at room temperature for 30 minutes, methyl {1,3-dimethyl-4-[1-(2-methylthiazol-4-yl)-methyloxy]pyrazol-5-yl}glyoxalate (0.6 g, 1.95 mmol) in anhydrous THF (6 ml) was added thereto and the mixture was allowed to stand for two hours. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over magnesium sulfate and concentrated in vacuo. The residue was chromatographed over silica gel to obtain (E)-methyl 2-{1,3-dimethyl-4-[1-(2-methylthiazol-4-yl)-methyloxy]pyrazol-5-yl}-3-methoxyacrylate (compound No. 9 in Table 1) as an oil (0.25 g, 38.1 %). According to the procedures described in the above Example 2, compounds No. 10 and 11 in Table 1 were prepared. The following Table 1 shows the compounds (I) of the invention obtained in the same manner as described in the above Examples 1 and 2. Table 2 shows examples of compounds (I) which are further obtainable according to the procedures described in Examples 1 and 2. Typical intermediates (II) used in the preparation of compounds (I) listed in the Table 1 are shown in the Table 4 with their physicochemical properties. The following Table 3 shows the ¹H NMR signals of typical compounds (I) listed in the above Table 1. The chemical shifts are expressed by ppm from tetramethylsilane. Unless otherwise noted, the solvent used is CDCL₃. The abbreviations used are as follows: s = singlet; d = doublet; t = triplet; q = quartet; m = multiplet; br = broad; dd = double doublet. The following formulation examples are illustrative only and are not intended to limit the scope of the invention in any way. Formulation 1 A wettable powder was prepared using the following ingredients: Quantity parts by weight Active compound (No. 1 in the Table 1) 20 diatomaceous earth 75 surfactant (principal component = alkylbenzene sulfonate) 5 The above ingredients are mixed and ground into a homogeneous powder. Formulation 2 A wettable powder was prepared using the following ingredients: Quantity parts by weight Active compound (No. 10 in the Table 1) 40 white carbon 10 diatomaceous earth 47 "Sorpol" 5039 (surfactant from TOHO Chemicals, Inc.: principal component = polyoxyethylene alkylaryl ether sulfonate) 3 The above ingredients are mixed and ground into a homogeneous powder. Formulation 3 An emulsifiable concentrated formulation was prepared using the following ingredients: Quantity parts by weight Active compound (No. 15 in the Table 1) 30 "Sorpol" 3005X (TOHO Chemicals, Inc.: nonionic/anionic surfactant blend) 15 xylene 25 dimethylformamide 30 The above ingredients are mixed to obtain an emulsifiable concentrated formulation which gives emulsion upon dilution with water. Formulation 4 A dust was prepared using the following ingredients: Quantity parts by weight Active compound (No. 1 in the Table 1) 2 N,N-kaolin clay (TSUCHIYA KAOLIN, Inc.) 98 The above ingredients are intimately mixed and ground to obtain a dust. The following Tests were performed to demonstrate the ability of the compounds of the invention to effect bactericidal and fungicidal action and to evaluate their agricultural- and horticultural-usefulness. In the Tests, the compounds of the invention are shown by the Nos. in the Table 1, while the control compounds are shown by the simboles used in the following Table 5. Test 1 Evaluation of Efficacy of the compound (I) on the Control of Wheat Powdery Mildew A wettable powder containing the test compound was prepared in the same manner as previously described in the Formulation 1 and diluted with water to obtain a test solution containing the test compound at a given concentraiton. The test solution was then applied to a wheat (variety : Norin No. 61; 1- or 2-leaf-stage) growing in a pot (6 cm in diameter) by stem-foliar application at the application rate of 10 ml per pot. After the test solution was air-dried, the plant was inoculated with Erysiphe graminis f. sp. tritici . The inoculation was conducted by spraying a suspension of spores collected from leaves of wheat infected with powdery mildew. The treated plants were maintained in a green house for 7 to 10 days and the portion of diseased area on leaves of each plant was measured. The disease control value was culculated as prevention value from the equation: prevention value (%) = [(A - B) / A] × 100 where A is the mean value of the percent of diseased area on untreated sections, B is the mean value of the percent of diseased area on treated sections. Results are shown in the following Table 6. Test 2 Evaluation of Efficacy of the compound (I) on the Control of Wheat Powdery Mildew (Systemic Activity Test) A wettable powder containing a test compound was prepared in the same manner as previously described in the Formulation 1 and diluted with water to obtain a test solution containing the test compound at a given concentration. Wheat seedlings (variety : Norin No. 61; 1- or 2-leaf-stage) were treated by immersing the roots into the test solution. Two days later, the seedlings were inoculated with Erysiphe graminis f. sp. tritici . The inoculation was conducted by spaying suspensions of spores collected from leaves of wheats infected with E. graminis f. sp. tritici . The treated plants were kept at room temperature for 7 to 10 days and the portion of diseased spot areas on leaves of each plant was measured. The disease control value was culculated as percent control from the equation: prevention value (%) = [(A - B) / A] × 100 where A is the mean value (%) of the percent diseased area on untreated sections, B is the mean value (%) of the percent diseased area on treated sections. Results are shown in the following Table 7. Test 3 Evaluation of Efficacy of the Compound (I) on the Control of Wheat Leaf Rust A wettable powder containing a test compound was prepared in the same manner as previously described in the Formulation 1 and diluted with water to obtain a test solution containing the test compound at a given concentraiton. The test solution was then applied to a wheat seedlings (variety : Norin No. 61; 1- or 2-leaf-stage) growing in a pot (6 cm in diameter) by stem-foliar application at the application rate of 10 ml per pot. After the test solution was air-dried, the seedlings was inoculated with Puccina recondita . The inoculation was conducted by spraying a suspension of spores collected by grinding wheat leaves infected with leaf rust. The inoculated plants were kept, at first, in a wet chamber at 22 °C for 15 hours, and than in a green house for 7 days. The portion of diseased area of each leaf was measured. The disease control value was culculated as percent control from the equation: prevention value (%) = [(A - B) / A] × 100 where A is the mean value (%) of the percent diseased area on untreated sections, B is the mean value (%) of the percent injured area on treated sections. Results are shown in the following Table 8. Test 4 Evaluation of Efficacy of the compound (I) on the Control of Late Blight of Tomato A wettable powder containing a test compound was prepared in the same manner as previously described in the Formulation 1 and diluted with water to obtain a test solution containing the test compound at a given concentraiton. Three seedlings of tomato (variety : Red cherry) were grown in a plastic pot (6 cm in diameter) until 3- or 4-leaf-stage. The test solution was applied to the seedlings by stem-foliar application at the application rate of 10 ml per pot. After the test solution was air-dried, the seedlings were inoculated with Phytophthora infestans . The inoculation was conducted by spraying a suspension of spores formed on detached leaves of tomato. The inoculated plants were kept, at first, in a wet chamber at 20 °C for 24 hours, and then in a green house for 2 days. The portion of diseased areas of the leaves was measured. The incidence of disease was rated using the following index: The incidence of disease (%) was culculated from the equation: where n₀, n₁, n₃, and n₅ are the number of leaves which give the index listed above per pot. The disease control value was culculated as percent control from the equation: prevention value (%) = [(A - B) / A] × 100 where A is the incidence (%) of disease on untreated sections, B is the incidence (%) of disease on treated sections. Results are shown in the following Table 9.

Claims: Claims for the following Contracting States : AT, BE, CH, DE, FR, GB, IT, LI, LU, NL A pyrazolyl acrylic acid derivative of formula (I): wherein: R₁ and R₂ are independently hydrogen or C₁ - C₅ alkyl; A is a group of formula wherein X is independently hydrogen; halogen; cyano; nitro; C₁ - C₁₀ alkyl, C₂ - C₁₁ alkenyl, C₁ - C₁₀ alkoxy, C₂ - C₁₁ alkenyloxy, C₂ - C₁₁ alkynyloxy, C₂ - C₁₁ alkylcarbonyl or C₂ - C₁₁ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl and C₁ - C₅ alkoxy; or C₇ - C₁₃ arylcarbonyl, C₄ - C₉ cycloalkylcarbonyloxy, C₇ - C₁₃ arylcarbonyloxy, C₆ - C₁₂ aryl, C₆ - C₁₂ aryloxy, C₂ - C₁₃ heteroaryl having 1 - 3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, C₂ - C₁₃ heteroaryloxy having 1 - 3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, C₇ - C₁₂ aralkyl or C₇ - C₁₂ aralkyloxy optionally substitutes with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁ - C₅ alkyl, and C₁ - C₅ alkoxy; m is 1 or 2; and n is a integer of 1 - 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached; and B is methoxycarbonyl or cyano. The pyrazolyl acrylic acid derivative of formula (I) as claimed in Claim 1, in which A is a group of formula: wherein X is independently hydrogen; halogen; cyano; nitro; C₁ - C₄ alkyl, C₂ - C₃ alkenyl, C₁ - C₃ alkoxy, C₂ - C₃ alkenyloxy, C₂ - C₃ alkynyloxy, or C₂ - C₅ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, and trifluoromethyl; or phenyl, phenoxy, benzyl, benzyloxy, thiazolyl, thiazolyloxy, pyridyloxy, benzoyl, or benzothiazolyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁ - C₄ alkyl and C₁ - C₄ alkoxy; m is 1 or 2; and n is a integer of 1 - 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached, where the fused ring is selected from 2,3-dihydrobenzofuran, chroman, naphtalene, fluorene, anthraquinone or benzo-1,3-dioxole. An agriculturally useful fungicidal composition comprising, as an active ingredient, a pyrazolyl acrylic acid derivative of formula (I) as claimed in Claim 1. An agriculturally useful fungicidal composition comprising, as an active ingredient, a pyrazolyl arylic acid derivative of formula (I) as claimed in Claim 2. A pyrazole derivative of formula (II): wherein R₁, R₂ and A are as defined in Claim 1; and E is ethoxycarbonyl or -CH₂-B where B is as defined in Claim 1. The pyrazole derivative of formula (II) as claimed in Claim 5, in which A is a group of formula: wherein X is as defined in Claim 2. A process for preparing the pyrazolyl acrylic acid derivative of formula (I) as claimed in Claim 1 or 2, which comprises the steps; (a) reacting a compound of formula (IIb): wherein R₁, R₂, A and B are as defined in Claim 1, with methyl formate and a base; and (b) reacting the compound obtained in step (a) or its salt with a methylation reagent in the presence or absence of a base. A process for preparing the pyrazolyl acrylic acid derivative of formula (I) as claimed in Claim 1 or 2, which comprises reacting a compound of formula (VI): wherein R₁, R₂, A and B are as defined in Claim 1, with a Wittig reagent in an appropriate solvent. A process of combatting phytopathogenic fungi characterized by applying at least one pyrazolyl acrylic acid derivative of formula (I). A process according to claim 9 characterized by applying the said compound(s) to plants, optionally with known adjuvants. Claims for the following Contracting State : ES A process for preparing a pyrazolyl acrylic acid derivative of formula (I): wherein: R₁ and R₂ are independently hydrogen or C₁₋₅ alkyl; A is a group of formula wherein X is independently hydrogen; halogen; cyano; nitro; C₁₋₁₀ alkyl, C₂₋₁₁ alkenyl, C₁₋₁₀ alkoxy, C₂₋₁₁ alkenyloxy, C₂₋₁₁ alkynyloxy, C₂₋₁₁ alkylcarbonyl or C₂₋₁₁ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl and C₁₋₅ alkoxy; or C₇₋₁₃ arylcarbonyl, C₄₋₉ cycloalkylcarbonyloxy, C₇₋₁₃ arylcarbonyloxy, C₆₋₁₂ aryl, C₆₋₁₂ aryloxy, C₂₋₁₃ heteroaryl having 1 to 3 heteroatom(s) selected from oxygen, sulfur and nitrogen, C₂₋₁₃ heteroaryloxy having 1 to 3 heteroatom(s) selected from oxygen, sulfur and nitrogen, C₇₋₁₂ aralkyl or C₇₋₁₂ aralkyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁₋₅ alkyl, and C₁₋₅ alkoxy; m is 1 or 2; and n is an integer of 1 to 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached; and B is methoxycarbonyl or cyano, which process comprises the following steps: (a) reacting a compound of formula (IIb): wherein R₁, R₂, A and B are as defined above, with methyl formate and a base; and (b) reacting the compound obtained in step (a) or its salt with a methylation reagent in the presence or absence of a base. A process according to claim 1 wherein A is a group of formula: wherein X is independently hydrogen; halogen; cyano; nitro; C₁₋₄ alkyl, C₂₋₃ alkenyl, C₁₋₃ alkoxy, C₂₋₃ alkenyloxy, C₂₋₃ alkynyloxy or C₂₋₅ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano and trifluoromethyl; or phenyl, phenoxy, benzyl, benzyloxy, thiazolyl, thiazolyloxy, pyridyloxy, benzoyl or benzothiazolyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁₋₄ alkyl and C₁₋₄ alkoxy; m is 1 or 2; and n is an integer of 1 to 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached, where the fused ring is selected from 2,3-dihydrobenzofuran, chroman, naphthalene, fluorene, anthraquinone or benzo-1,3-dioxole. A process for preparing a pyrazolyl acrylic acid derivative of formula (I) as defined in claim 1, which comprises reacting a compound of formula (VI): wherein R₁, R₂, A and B are as defined in claim 1, with a Wittig reagent in an appropriate solvent. A process according to claim 3, wherein A is a group of formula: wherein X is independently hydrogen; halogen; cyano; nitro; C₁₋₄ alkyl, C₂₋₃ alkenyl, C₁₋₃ alkoxy, C₂₋₃ alkenyloxy, C₂₋₃ alkynyloxy or C₂₋₅ alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano and trifluoromethyl; or phenyl, phenoxy, benzyl, benzyloxy, thiazolyl, thiazolyloxy, pyridyloxy, benzoyl or benzothiazolyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl, C₁₋₄ alkyl and C₁₋₄ alkoxy; m is 1 or 2; and n is an integer of 1 to 5; or two Xs may form a fused ring together with the benzene ring or thiazole ring to which they are attached, where the fused ring is selected from 2,3-dihydrobenzofuran, chroman, naphthalene, fluorene, anthraquinone or benzo-1,3-dioxole. A process of combatting phytopathogenic fungi characterized by applying at least one pyrazolyl acrylic acid derivative of formula (I). A process according to claim 5 characterized by applying said compound(s) to plants, optionally with known adjuvants. The use of a a pyrazolyl acrylic acid derivative of formula (I) as prepared in any of claims 1 to 4 for preparing an agriculturally useful fungicidal composition.

Inventors: KIKUTAKE KUZUHIKO, ODA MASATSUGU RYOKA-DAI-NI, SAKAKI TOSHIRO, KIKUTAKE, KUZUHIKO, ODA, MASATSUGU, RYOKA-DAI-NI, SAKAKI, TOSHIRO
Applicants: MITSUBISHI CHEM CORP, MITSUBISHI CHEMICAL CORPORATION
Application year: 1990
Main classification: C07D231
IPC codes: C07D417, C07D231, C07D401, C07D405