1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS

Abstract: Certain N-dicycloalkyl or N-branched-alkylbenzamides of imidazo[4,5-c]pyridines are useful in treatment of platelet dysfunction or hyperactivity by inhibiting PAF-induced platelet aggregation. Compounds of particular interest are those of formula (I), wherein Y is hydrido at all substitutable phenyl ring positions or is fluoro or methoxy at the 2- or 6-positions of the phenyl ring, and wherein each of R<1> and R<2> is independently selected from cycloalkyl and branched alkyl.

Description: 1H/3H-[4-( ,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)- BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS RELATED APPLICATION This application is a continuation-in-part of U.S. Application Ser. No. 07/168,491 filed March 15, 1988. FIELD OF THE INVENTION This invention is in the field of mammalian therapeutics and relates to compounds for treatment of mammalian diseases such as inflammation, cardiovascular disorders, asthma and other diseases. Of particular interest is a class of novel N-dicycloalkyl or N-branched-alkyl benzamides of certain imidazopyridine derivatives useful for treatment of cardiovascular and immuno-inflammatory related disorders .mediated by platelet activating factor (PAF) ' . BACKGROUND OF THE INVENTION Chronic platelet dysfunction or hyperactivity of platelets is associated with many chronic diseases such as cerebrovascular disease, ischemic heart disease, diabetic retinopathy, angina, peripheral vascular disease and yocardial infarction. Platelet activation results in platelet aggregrate formation and the release of substances which can accelerate platelet aggregation. Platelet activation may be stimulated by any of several aggregatory agents through various mechanisms depending upon the particular disorder at hand. Aggregatory agents, such as collagen, thromboxane A 2 (TXA 2 ), adenosine diphosphate (ADP), adrenaline, 5-hydroxytryptamine, thro bin, or platelet activating factor (PAF), may act directly on receptors resulting in platelet aggregation, or may alter cyclic-AMP levels or calcium ion sequestration to produce platelet aggregation. Platelet-activating factor (PAF) has been associated with various biological activities and pathways, thus making it an important mediator responsible for a variety of physiological processes, including activation of platelets, smooth muscle contraction, pathogenesis of immune complex deposition, inflammation, and respiratory, cardiovascular and intravascular alterations. These physiological processes are associated with a large group of diseases, such as cardiovascular disorders, asthma, lung edema, endotoxin shock, adult respiratory distress syndrome and inflammatory diseases. Various classes of compounds are known for inhibiting platelet activation induced by agents such as arachidonic acid, collagen and platelet activating factor. For example, several classes of imidazole derivatives are known for use in treatment of various cardiovascular and immuno-response diseases related to platelet dysfunction or hyperactivity. U.S. Patent No. 2,025,946 to Iizuki et al mentions certain classes of imidazoles, namely, N-(ω-substituted alkylphenyl- alkyl)imidazoles, N-(i_-substituted alkylphenyl)- imidazoles and N-(nucleus-substituted phenylalkyl)- imidazoles which are described as having inhibitory effect on thromboxane εynthetase and to be useful for treatment of inflammation, thrombus and asthma. U.S. Patents No. 4,284,641 and No. 4,416,895 to Thorogood describe certain cycloalkyl/cycloalkenyl imidazoles which inhibit platelet aggregation or- reduce the adhesive character of platelets by selective inhibition of thromboxane A 2 . Also described for the same purpose in U.S. Patent No. 4,537,340 to Thorogood is a class of 1-arylalkylimidazoles. In U.S. Patent No. 4,243,671 to Harris et al, the compound l-(3-phenyl-2-propenyl)lH-imidazole is described as effective in inhibiting thromboxane synthetase, arachidonic acid-induced platelet aggregation and bronchoconstrictio . Compounds are known for use in treating platelet dysfunction or hyperactivity induced specifically by platelet activating factor (PAF). For example, a certain class of glycerol derivatives useful as PAF antagonists is described in European Application No. 142,333. A class of indene derivatives is described in European Application No. 142,801 as PAF inhibitors. Compounds containing heterocyclic moieties of various types are also known as PAF antagonists.' U.S. Patent No. 4,579,862 to Manley et al describes certain imidazole/pyridinyl- alkanoic acid derivatives as PAF antagonists. South African Application No. 87/6817 describes a class of imidazopyridine derivatives useful as PAF inhibitors and mentions, in particular, the compound N-cyclohexyl- N-methyl-4-(lH-imidazo[4,5-c]pyridin-l-yl-methyl)- benza ide as an inhibitor of PAF-induced aggregation in an assay using human platelet-rich plasma. DESCRIPTION OF THE INVENTION Treatment of platelet-related pathologies, such as PAF-stimulated pathologies or platelet-mediated airway hyper-reactivity, in a mammal is accomplished by administering to a.susceptible mammal a therapeutically- effective amount of a compound of the class represented by Formula I: R 4 wherein one of W and X is N and the other of and X is -CH-; wherein Y is one or more groups which may be the same or different attached at one or more of the 2-, 3-, 5- or 6-positions of the phenyl ring, with Y independently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, ercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, mono- alkylamino, dialkylamino and alkylthioalkyl; wherein Z is a group substituted at one of the 3-, 4- or 5-positions of the phenyl ring, O li / R 1 said group being -CN with each of R 1 and R 2 R 2 independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl ' and halophenyl; wherein each of R 3 , R 4 and R 5 is independently selected from hydrido, halo, alkyl and alkoxy; and wherein n is an integer from zero to four; or a pharmaceutically-acceptable salt thereof. ithin the class of compounds defined by Formula I, there is a sub-class of preferred compounds represented by Formula II: wherein Y is one or more groups which may be the same or different attached at one or more of the 2-, 3-, 5- or 6-positions of the phenyl ring, with Y independ¬ ently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano,. alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkyla ino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 is independently selected from branched alkyl, cycloalkyl, -alkylcycloalkyl, phenyl, alkylphenyl and halophenyl; and wherein each of R 3 and R 4 is independ¬ ently selected from hydrido, halo, alkyl and alkoxy. A preferred class of compounds within Formula II consists of those compounds wherein Y is independently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 is independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl, fluorophenyl, chlorophenyl and bromophenyl; wherein each of R 3 and R 4 is independently selected from hydrido and alkyl; with the proviso that when any of the foregoing substituents contains one or more linear or branched alkyl portions, said alkyl portion has one to about twelve carbon atoms, and that when any of the foregoing substituents contains a cycloalkyl portion, said cycloalkyl portion contains three to about eight carbon atoms. A more preferred class of compounds within Formula II consists of those compounds wherein Y is independently selected from hydrido, fluoro, chloro, bromo, alkyl, amino, monoalkylamino, dialkylamino and alkoxy; wherein each of R 1 and R 2 is independently selected from branched alkyl, cycloalkyl and alkyl¬ cycloalkyl; and wherein each of R 3 and R 4 is independ¬ ently selected from hydrido and alkyl. An even more preferred class of compounds within Formula II consists of those compounds wherein Y is independently selected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl, isopropyl, butyl, iεobutyl, sec-butyl, tert-butyl, n-pentyl, neopentyl, n-hexyl, iso-hexyl,- n-heptyl, n-octyl, amino, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-die hy1amino, methoxy, ethoxy, propoxy, methoxy¬ methyl and hydroxymethyl; wherein each of R 1 and R 2 is independently selected from isopropyl, isobutyl, sec-butyl, tert-bxityl, 2-pentyl, 3-pentyl, neopentyl, isopentyl, 2-methylpentyl, 2-hexyl, 3-hexyl, 3-methyl- pentyl, 4-methylpentyl , 2,2-dimethylpentyl, 2,3-dimethyl- pentyl, isooctyl, 2,2,4-trimethylpentyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl, any one of which cycloalkyl groups may be substituted with one or more lower alkyl groups and wherein each of R 3 and R 4 is independently selected from hydrido, methyl, ethyl and n-propyl. A particularly preferred class of compounds within Formula II consists of those compounds wherein Y is one or two groups which may be the same or different attached at one or more positions selected from the two, three, five and six positions of the phenyl ring, with Y independently selected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl, and methoxy, amino, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino, methoxymethyl and hydroxymethyl; wherein each of R 1 and R 2 is independently selected from isopropyl, sec-butyl, 2-pentyl, 3-pentyl, 2-hexyl, 3-hexyl, cyclopentyl, methylcyclopentyl, cyclohexyl and methylcyclohexyl; wherein each of R 3 and R 4 is independently selected from hydrido and methyl. A more particularly preferred class of compounds within Formula II consists of those compounds wherein Y is hydrido at all substitutable positions or Y is one or two groups attached at positions selected from the two, three, five and six positions of the phenyl ring with Y independently selected from fluoro, bromo, methyl and methoxy; wherein each of R 1 and R 2 is independently selected from isopropyl, sec-butyl, cyclopentyl, methylcyclo- pentyl, cyclohexyl and methylcyclohexyl; and wherein each of R 3 and R 4 is hydrido. Compounds of most interest of Formula II are those wherein :'the substitutable positions on the nitrogen atom of the benzamide moiety are substituted as follows: (a) substitution with cycloalkyl groups such as cyclopentyl, cyclohexyl, methylcyclopentyl and methylcyclohexyl; or (b) substitution with branched alkyl groups which have configurations which mimic the presence of the aforementioned cycloalkyl groups, such branched alkyl groups being, for example, isopropyl, sec-butyl, iεobutyl, 2-pentyl, 3-pentyl, 2-hexyl and 3-hexyl; or (c) substitution with groups from (a) and (b), above. The term "branched alkyl" denotes non-linear, acyclic alkyl moieties having three to twelve carbon atoms. Examples of compounds of Formula II having the benzamide nitrogen substituted with two cycloalkyl groups, or two branched alkyl groups, or a cycloalkyl and a branched alkyl group, are those of Formula III presented in Table I, below: Table I - Preferred Compounds IH-{4-[N-(R 1 )-N-(R 2 )-carboxamido]-Y-benzy1}imidazo[4,5-c]pyridine Substitution :ompound # R 1 R 2 Y 1 cyclopentyl cyclope tyl - 2 cyclopentyl cyclohexyl - 3 cyclopentyl 3-methylcyclohexyl - 4 2-propyl cyclohexyl 2- -methoxy 5 2-propyl cyclohexyl - 6 cyclopentyl 3-methylcyclohexyl 2- -bromo, 5--methoxy 7 cyclopentyl cyclopentyl 2- -fluoro 8 cyclohexyl cyclohexyl - 9 sec-butyl cyclopentyl - 10 sec-butyl cyclohexyl - 11 2-pentyl cyclopentyl - 12 3-pentyl cyclopentyl - 13 2-hexyl cyclopentyl - 14 3-hexyl cyclopentyl - 15 sec-butyl cyclopentyl 2- -methoxy 16 sec-butyl cyclohexyl 2- -methoxy Of the foregoing specific examples , most preferred are the following: IH- [4-(N,N-dicyclopentylcarboxamido)benzyl] imidazo- [4, 5-c]pyridine; IH- [4- (N-cyclopentyl-N-cyclohexylcarboxamido ) benzyl ] - imidazo [4 , 5-c]pyridine ; IH- [4- (N-cyclopentyl-N-3-methylcyclohexylcarboxamido) - benzyl] imidazo [4, 5-c]pyridine; 1H-[4-(N-2-propyl-N-cyclohexylcarboxamido)-2-methoxy- benzyl]imidazo[4,5-c]pyridine; lH-[4-(N-2-propyl-N-cyclohexylcarboxamido)benzyl]- [4,5-c]pyridine; and lH-{2-bromo-5-methpxy-4-[N-cyclopentyl-N-2-methylcyclo¬ hexyl)carboxamido]benzyl}imidazo[4,5-c]pyridine. Included within the classes and sub-classes of compounds embraced by Formulas I, II and III are the tautomeric forms of the described compounds, isomeric forms including diastereoisomers and enantiomers, and the pharmaceutically-acceptable salts thereof. The term "pharmaceutically-acceptable salts" embraces salts commonly used to form alkali metal salts and to form addition salts of free acids or free bases. Since- the compounds of Formulas I, II and III contain basic nitrogen atoms, such salts are typically acid addition salts or quaternary salts. The nature of the salt is not critical, provided that it is phar aceutially acceptable, and acids which may be employed to form such salts are, of course, well known to those skilled in this art. Examples of acids which may be employed to form pharmaceutically acceptably acid addition salts include such inorganic acids as hydrochloric acid, sulphuric acid and phos- phoric acid, and such organic acids as maleic acid, εuccinic acid and citric acid. Other pharmaceutically acceptably salts include salts with alkali metals or alkaline earth metals, such as sodium, potassium, calcium and magnesium, or with organic bases, such as dicyclohexylamine. All of these salts may be prepared by conventional means by reacting, for example, the appropriate acid or base with the corresponding compound of Formulas I, II and III. Where the term "alkyl" is used, either alone or within other terms such as "alkoxyalkyl", the term "alkyl" embraces linear or branched alkyl radicals having one to about twelve carbon atoms, such that the group "alkoxyalkyl" having two alkyl portions could contain two to about twenty-four carbon atoms. More preferred linear alkyl radicals are "lower alkyl", or "lower alkoxyalkyl 1 .', radicals having one to about five, or two to about ten, carbon atoms, respectively. The term "cycloalkyl" embraces cyclic radicals having three to about eight ring carbon atoms, and preferably five or six ring carbon atoms such as cyclopentyl or cyclohexyl. The term "alkylcycloalkyl" denotes a C___ 8 cycloalkyl having one or more alkyl radicals, preferably lower alkyl radicals, attached to one or more substi¬ tutable ring carbons. The term "hydroxyalkyl" embraces linear or branched alkyl groups having one to about twelve carbon atoms any one of which may be substituted with one or more hydroxyl groups. The terms "alkoxy" and "alkylthio" embrace linear or branched oxy- containing or thio-containing radicals, respectively, having alkyl portions of one to about twelve carbon atoms attached at a substitutable position, designated by the Y position of Formulas I and II, through the oxygen or sulfur atom, respectively. The term "mercaptoalkyl" denotes a terminal mercapto group attached to an alkyl portion of one to about twelve carbon atoms which, in turn, is attached at a sub¬ stitutable position of the phenyl ring designated by the Y substituent of Formulas I, II and III. The term "hydrido" denotes a single hydrogen atom (H) attached at a substitutable position represented by the sub- stituents Y, R 3 , R 4 and R 5 of Formulas I, II and III, above. Where no substitution is indicated by a group other than hydrido, it is .understood that such sub¬ stitutable position of the phenyl ring designated by Y, R 3 , R 4 and R ε is occupied by hydrido. Synthetic Procedures Compounds of Formulas I, II and III may be prepared in accordance with the following general procedures, which are described for convenience with regard to the sub-class of compounds of the invention defined by Formula II, above: An imidazo[4,5-c]pyridine intermediate, as shown in its tautomeric mixture form (IV) is reacted with an alkylbenzamide intermediate (V) wherein each of Y and R 1 through R 5 is selected as described above, and T is selected from chloro, bromo, iodo, an alkylsulfonyloxy such as methanesulfonyloxy and an arylsulfonyloxy such as para-toluenesulfonyloxy, with T preferably being bromo. The alkylation reaction of the imidazo[4,5-c]pyridine intermediate (IV) with a suitable alkylbenzamide intermediate (V) can be carried out in accordance with the following general proceudre: Imidazopyridine (10 mmole) is dissolved in a dipolar aprotic solvent such as DMF and stirred at 0-25°C. To thiε a base such as sodium hydride (10-15 mmole), potassium hydride (10-15 mmole), potassium-t-butoxide (10-15 mmole), or a complex of potassium-t-butoxide (10-15 mmole) with 18-crown-6 (1 mmole), is added over 10 minutes. The reaction mixture is stirred at room temperature for 1-6 hours. The reaction flask is cooled (0-20°C) and a solution of substituted benzyl bromide in a dipolar aprotic solvent is added over 15-20 minutes. The reaction mixture is stirred for 4-16 hours. After quenching with acid (1 N HC1 or acetic acid), part of the solvent is removed under reduced pressure. The reaction is diluted with ethyl acetate and the organic layer is washed with saturated K 2 C0 3 , water and brine. After drying over Na 2 S0 4 , the solvent is removed and the residue is chromatographed (εilica gel, CH 2 C1 2 : methanol: NH 4 0H 90:10:1) to give the desired product-. Preparation of Imidazo[4,5-c]pyridine (IV) An example of a εpecific method for preparation of the imidazo[4,5-c]pyridine intermediate, from which the general preparation of intermediate (IV), above, may be derived, is as follows: A εtirred mixture of 3,4-diaminopyridine (10.0 g, 0.092 mol) and formic acid (20 ml) waε heated under reflux for 2.5 hours. The resulting mixture was cooled and the formic acid was evaporated off under reduced pressure to yield a residue. The residue waε dissolved in ethanol (30 ml) at 80°C and the resulting solution was treated with calcium carbonate (10 g) and neutralized by stirring under reflux for 1 hour. The hot mixture was filtered and the residue was washed with hot ethanol (3 x 300 ml). The filtrate and washings were combined and the ethanol was evaporated off under reduced pressure to yield 3,4-diformylaminopyridine as a colorless solid. The 3,4-di ormylaminopyridine was heated at 200-220°C and 0.5 mm Hg pressure in a Kugelrohr bulb-to-bulb distillation apparatus to yield a crude product as a distillate which solidified on cooling. The crude product was recryεtallized from ethyl acetate to yield imidazo[4,5-c]pyridine aε a colorleεs crystalline solid, having a melting point of 174-176°C and the following physical characteristics: 1H-NMR (δ, DMSO-d 6 ): 6.60 (broad S,1H), 7.66 (dd,lH), 8.37 (d,lH), 8.44 (ε,lH) and 9.00 (d,lH). A variation of the foregoing procedure may be used to prepare derivatives substituted with halo, alkyl or alkoxy groups such as 2-, 4- or 7-εubstituted derivatives of the imidazo[4,5-c]pyridine intermediate (IV). For example, the 4-methyl-imidazo[4,5-c]pyridine intermediate [R 4 =methyl of (IV)] may be prepared in accordance with the following scheme and description: The imidazo[4,5-c]pyridine wherein R 4 is methyl is prepared according to the scheme above starting with the imidazopyridine of Formula IV. Poεition 1 of this compound is protected by reaction with a 2-(trialkylsilyl)ethoxymethyl chloride and a base such as sodium hydride in a polar aprotic solvent such as dimethylformamide. This reaction is carried out at room temperature. A specific example of such a protecting group is 2-(trimethylεilyl)ethoxy- methyl chloride. The protected imidazopyridine is reacted with phenyl chloroformate and methylmagnesiu bromide in an ether solvent such as tetrahydrofuran at about -20°C. The methylated product bearing phenoxy- carbonyl at position 5 is treated with a base, such aε alcoholic sodium hydroxide, at reflux for 24 hourε. The product is oxidized with, for example, chloranil, and the 2-(trimethylεilyl)ethoxymethyl group is removed by treatment with a suitable acid. An example of such ari acid would be trifluoroacetic acid. Preparation of.Alkylbenzamide Intermediates (V) The alkylbenzamide intermediate (V), suitably substituted on the amide nitrogen with two cycloalkyl groups, or two branched alkyl groups, or both a cycloalkyl group and a branched alkyl group, may be prepared by procedures generally known in the art [see, for example, V.S. Chauhan et al. Int. J. Peptide Protein Reε., 15, 96-101 (1980)]. Preparation of suitable secondary amine precursors to the alkylated benzamide intermediate (V) is generally known [see, for example, W.S. Emerson, Orq. Reactions, , 174 (1948); and J.B. Campbell et al, "Catalysis in Organic Synthesis", p. 43, Academic Press, New York (1980)]. Key alkylbenzamide intermediates (V) may be prepared in accordance with the following generalized procedures: General Method for Preparation of Secondary Amines: To a solution of ketone (0.1 mol), amine (0.1 mol), and acetic acid in ethanol (100 mL) in a Parr bottle was added 5% Pd/C (1 g). The bottle was sealed, purged with nitrogen and presεurized (60 psi) with hydrogen. The reaction was stirred at room temperature (2-20 hours) until the theoretical amount of hydrogen was taken up. The reaction vessel was vented, purged with nitrogen and filtered. The clear filtrate waε concentrated, the residue disεolved in ethyl acetate and waεhed with saturated aqueous potassium carbonate, water and brine. After drying over MgS0 4 , the solvent was removed to give the crude product which was distilled under presεure to provide product having sufficient purity for the amidation reaction. General Method of Preparation of 4-Methyl-3-Methoxy and 3-Fluoro Benz ides and Amides of _-Bromo-p-Toluic Acid ' f The acid -chlorides were prepared from the corresponding carboxylic acids by refluxing in thionyl chloride (2 molar excess) for two hours. Excess thionyl chloride was removed by azeotrope four times with toluene (150 ml portions). The residual acid chloride was dissolved in THF (12 ml/g of acid) and cooled to about -10°C. A solution of two molar equivalents of the amine in THF (10 ml/g of amine) was added dropwiεe with εtirring. When addition was completed, the reaction was allowed to warm to room temperature and stirred for 1-2 hourε. The reaction was quenched with IN HC1, diluted with H 2 0, and extracted three times with ethyl acetate (150 ml portions). The combined organic layers were washed three times with saturated aqueous sodium bicarbonate solution (200 ml portionε), once with water (300 ml), three times with saturated aqueous sodium chloride solution (200 ml portions) and dried over sodium sulfate) . The drying agent was filtered and the filtrate concentrated under reduced pressure to give a crude product that- as chromatographed on silica gel using mixtures of ethyl acetate and hexane to give the purified amide. General Method for the Preparation of: 4-Bromomethyl-3-Methoxy and -3-Fluoro Benzamides A stirred mixture of the amide and N-bromosuccinimide (NBS) (1:1 molar ratio) in carbon tetrachloride was irradiated with a sun lamp for 1-3 hours. A white precipitate was filtered and washed with a minimum amount of CHC1 3 . The filtrate was washed with water and the aqueous layer, after basification with ammonium hydroxide, was extracted three times with chloroform (150 ml portions). All organic layers were combined, washed three times with saturated aqueous [sodium chloride solution and dried over sodium sulfate. The drying agent was filtered and the filtrate concentrated under reduced pressue to give a crude product that was chromatographed on silica gel using mixtures of ethyl acetate and hexane to give the purified bromomethyl compound. The following Examples 1-6 are detailed descriptionε of the key synthetic step for preparing compounds of the invention. These detailed preparations fall within the scope of, and serve ' to exemplify, the more generally described procedureε above. Theεe Exampleε 1-6 are presented for illustrative purposeε only and are not intended aε a reεtriction on the εcope of the invention. Most of the commercially-available materials were obtained from Aldrich Chemical Co., Milwaukee, Wis. Example 1 la lb la: IH-[4-(N,N-dicyclopentylcarboxamido)benzyl]imidazo- [4,5-c]pyridine lb: 3H-[4-(N,N-dicyclopentylcarboxamido)benzyl]imidazo- [4,5-c]pyridine To a solution of imidazopyridine (2.5 g, 21 mmol) in DMF ( 00 ml) at 0°C, sodium hydride (1.3 g, 60% dispersion in mineral oil, 32.5 mmol) was added over 15 in. in 4 portions. The reaction mixture was stirred at 0°C for 1 hour and then at room temperature for 2 hours. After recooling (0-5°C), a solution of N,N-dicyclopentyl-4-bromomethyl benzamide (7.35 g, 21 mmol) in DMF (50 ml) was added over 5-10 min. The reaction was allowed to warm to room temperature and stirred or 4 hours. After carefully quenching with IN HCl, some DMF was removed under reduced pressure. The crude residue waε diluted with ethyl acetate and the organic layer waε washed sequentially with saturated potassium carbonate, water and brine. The organic layer waε concentrated to give 7.9 g of the residue. After chromatography (silica gel, CH 2 Cl 2 /MeOH/NH 4 OH 90/10/1), Products l _ (700 mg) and lb (442 mg) were isolated. Both la and lb were crystallized from EtOAc/CH 3 CN (85/15) to give white crystalline compounds. Anal. Calc. Found M.P.°C Cpd. la: C 24 H 28 N 4 0-0.2H 2 0 C 73.54 73.57 227-228 H 7.32 7.45 N 14.30 14.31 Cpd. lb: C 24 H 28 N 4 0 C 74.22 74.11 212-213 H 7.21 7.0 N 14.43 14.48 Example 2 ___ ___ 2a: lH-[4-(N-cyclopentyl-N-cyclohexylcarboxamido)benzyl]- imidazo[4,5-c]pyridine 2b: 3H-[4-(N-cyclopentyl-N-cyclohexylcarboxamido)benzyl]- imidaz ' o[4,5-c]pyridine To a solution of imidazopyridine (1.5 g 12.59 mmol) in Dl (50 mL), sodium hydride (755 mg, 60% dispersion in|mineral oil, 18.9 mmol) was added over 15 min. at 0-5°C. After stirring at room temperature for 8 hours, a solution of N-cyclopentyl-N- cyclohexyl-4-bromomethylbenzamide (5.5 g, 15.11 mmol) in 50 mL DMF was added over 10 min. The reaction was stirred at room temperature for about 18 hours and quenched with IN HCl. Part of the solvent was removed under reduced pressure and the reaction contents were diluted with ethyl acetate. The organic layer was washed with saturated potassium carbonate, water and brine. After drying over MgS0 4 , the solvent was removed and the residue chromatographed (silica gel; CH 2 C1 2 : EtOH:NH 4 OH 75:25:1) to give 2a (443 mg, 9%) and 2b (133 mg, 3%). Anal . Calc . Found . M. P . °C Cpd. ___- C 2 5 H 3 0 N 4 OO .5H 2 O c 72.96 72 .80 228-229 H 7.59 7.46 N 13 .61 13 .50 Cpd. 2b : C 2 sH 3 oN 4 0- 0 .25H 2 0 C 73 .26 73 . 96 222-224 H 7.56 7.54 N 13 .76 13 .75 Example 3 3a 3b 3a: IH-[4-(N-cyclopentyl-N-3-methylcyclohexylcarboxamido)- benzyl]imidazo[4,5-c]pyridine 3b: 3H-[4-(N-cyclopentyl-N-3-methylcyclohexylcarboxamido)- benzyl]imidazo[4 ,5-c]pyridine To a solution of imidazopyridine (1.19 g, 10 mmol) in DMF (50 mL), sodium hydride (660 mg, 60% disperεion in mineral oil, 15 mmol) iε added over 15 min. at 0-5°C. After stirring at room temperature for 5 hours, a solution of N-cyclopentyl-N-3-methylcyclo- hexyl-4-bromomethylbenzamide (3.78 g, 10 mmol) iε added over 15 min. The reaction is stirred for about 8 hours and quenched with IN HCl. Part of the solvent is removed under reduced pressure and the reaction contentε are diluted with ethyl acetate. The organic layer iε waεhed with εaturated potaεεium carbonate, water and brine. After drying over MgS0 4 , the solvent is removed and the residue chromatographed (silica gel; CH 2 C1 2 :MeOH:NH 4 OH 90:10:1) to give pure product. Examole 4 4a 4b 4a: IH-[4-(N-2-propyl-N-cyclohexylcarboxamido)-2- methoxybenzyl]imidazo[4,5-c]pyri ine 4b: 3H-[4-(N-2-propyl-N-cyclohexylcarboxaπιido)-2- methoxybenzyl]imidazo[4,5-cjpyri ine To a solution of imidazopyridine (1.2 g, 10.08 mmol) in DMF * (50 mL), sodium hydrido (605 mg, 60% dispersion in (mineral oil, 15.2 mmol) was added over 15 min. at 0-5°C. After stirring at room temperature for 8 hours, a solution of 3-methoxy-4- bromomethyl-N-isopropyl,N-cyclohexylbenzamide (4.5 g, 12.1 mmol) in 50 mL DMF was added over 10 min. The reaction was stirred at room temperature for about 18 hours and quenched with IN NCI. Part of the solvent was removed under reduced pressure and the reaction contents were diluted with ethyl acetate. The organic layer was washed with saturated potassium carbonate, water and brine. After drying over MgS0 4 , the solvent waε removed and the residue (5.4 g) chromatographed (silica gel; CH 2 C1 2 :CH 3 OH: NH 4 OH 85:15:1) to give 4a (993 mg, 24%) and 4b (666 mg, 16%) Anal. Calc. Found M.P.°C C24Ξ30N40 2 C 70.90 70.80 160-161 H 7.43 7.54 N 13.78 13.67 Cpd. 4b: C 24 HsoN 4 0 2 C 73.26 73.96 222-224 H 7.56 7.54 N 13.76 13.75 Example 5 ___ ___ 5a: IH-[4-(N-2-propyl-N-cyclohexylcarboxamido)benzyl]- imidazo[ ,5-cIpyridine 5b: 3H-[4-(N-2-propyl-N-cyclohexylcarboxamido)benzyl]- imidazo[4,5-c]pyridine To a solution of imidazopyridine (1.4 g, 11.8 mmol) in DMF (50 mL), sodium hydride (710 mg, 60% dispersion in mineral oil, 17.7 mmol) was added over 15 min. ' at 0-p°C. After stirring at room temperature for 8 hours, a solution of N-isoprop 1-N-c clohexy1-4-bromometh lbenzamide (4.8 g, 14.2 mmol) in 50 mL DMF was added over 10 min. The reaction waε εtirred at room temperature for about 18 hours and quenched with IN HCl. Part of the solvent waε removed under reduced pressure and the reaction contents were diluted with ethyl acetate. The organic layer waε waεhed with saturated potassium carbonate, water and brine. After drying over MgS0 4 , the solvent was removed and the residue (4.1 g) chromatographed (silica gel; CH 2 C1 2 : CH 3 OH : NH 4 OH 90:10:1) to give 5a (1200 mg, 28%) and 5b (780 mg, 18%). ial . Calc . Found M.P. °C Cpd. 5a: C 2S H 28 N 4 O-0.25H 2 O C 72.50 72.34 202-203 H 7.25 7.48 N 14.71 14.58 Cpd. 5b: C 23 H 28 N 4 0 C 73 .37 73.34 233-234 H 7.49 7.55 N 14.88 14.64 Example 6 6a 6b 6a: lH-{2-bromo-5-methoxy-4-[(N-cyclopentyl-N-2-methyl- cyclohexyl)carboxamido]benzyl}imidazo[4,5-c]pyridi 6b: 3H-{2-bromo-5-methoxy-4-[(N-cyclopentyl-N-2-methyl- cyclohexyl)carboxamido]benzyl}imidazo[4,5-c]pyridin To a solution of imidazopyridine (997 mg, 8.38 mmol) in DMF (30 mL), sodium hydride (400 mg, 60% dispersion in mineral oil, 9.95 mmol) was added over 15 min. at 0-5°C. After stirring at room temperature for 8 hours, a solution of 3-bromo-2- methoxy-4-bromomethyl-N-cyclopentyl, N-2-methylcyclo- hexylbenzamide (3.8 g, 9.3 mmol) in 50 mL DMF was added over 10 min. The reaction was stirred at room temperature for about 18 hours and quenched with IN HCl. Part of the solvent waε removed under reduced pressure and the reaction contents were diluted with ethyl acetate. The organic layer was washed with saturated potassium carbonate, water and brine. After drying over MgS0 4 , the solvent was removed and the residue (4.35 g) chromatographed (silica gel; CH 3 C1 2 : EtOH : NH 4 0H 90:10:1) to give 6a. (1.1 g, 29%) and 6b (340 mg, 9%). Anal. Calc. Found M.P.° Cpd. 6a: C 27 H 33 N 4 0 2 Br-1.0H 2 O C 59.67 59.69 209-2 H 6.49 6.22 N 10.30 10.26 Br 14.10 14.50 Cpd. 6b: C 27 H 33 N O 2 Br-0.5H 2 O C 60.67 60.28 116- H 6.60 6.30 N 10.48 10.24 Br 14.95 16.11 Thiε invention also relates to a method of treatment for patients (or mammalian animals raised in the dairy, meat, or fur industries or as pets) suffering from disorders or diseases which can be attributed to PAF as previously described, and more specifically, to a method of treatment involving the administration of a compound of Formulas I, II or III as the active ingredient. Accordingly, compound of the invention can be used among other things to reduce inflammation, to correct respiratory, cardiovascular, and intravascular alterations or diεorderε, and to regulate the activation or coagulation of plateletε, the pathogeneεis of immune complex deposition and smooth muscle contractions. For the treatment of inflammation, cardio¬ vascular disorder, asthma, or other diseases mediated by PAF, compound of the invention may be admini¬ stered orally, topically, parenterally, or by inhalation spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includeε subcutaneous injections, intravenous, intramuscular, intraεternal injection or infusion techniqueε. The compoundε of the preεent invention may be adminiεtered by any εuitable route, preferably in the form of a pharmaceutical composition adapted to such a route, and in a doεe effective for the treatment intended. Therapeutically effective doses of the compounds of the present invention required to prevent or arrest the progress of the medical condition are readily ascertained by one of ordinary skill in the art. Accordingly, the invention provideε a class of novel pharmaceutical compositions comprising one or more compounds of the present invention in association with one or more non-toxic, pharmaceutically acceptable carriers and/or diluents and/or adjuvants (collectively referred to herein as "carrier" materials) and if desired other active ingredients. The compounds and composition may, for example, be administered intra- vaεcularly, intraperitoneally, subcutaneously, intra- muscularly or topically. For oral administration, the pharmaceutical composition may be in the form of, for example, a tablet, capsule, suspension or liquid. The pharma¬ ceutical composition is preferably made in the form of a dosage unit containing a particular amount of the active ingredient. Exampleε of such dosage units are tablets or capsules. These may with advantage contain an amount of active ingredient from about 1 to 250 mg, preferably from about 25 to 150 mg. A suitable daily dose for a mammal may vary widely depending on the condition of the patient and other factors. However, a dose of from about 0.1 to 3000 g/kg body weight, particularly from about 1 to 100 mg/kg body weight, may be appropriate. The active ingredient may also be admin¬ istered by injection as a composition wherein, for example, saline, dextrose or water may be used as a suitable carrier. A suitable daily dose is from. about 0.1 to 100 mg/kg body weight injected per day in multiple doses depending on the disease being treated. A preferred daily dose would be from about 1 to 30 mg/kg body weight. The dosage regimen for treating an infectious disease condition with the compounds and/or compositions of this invention is selected in accordance with a variety of factors, including the type, age, weight, sex and medical condition of the patient, the severity of the infection, the route of administration, and the particular compound employed, and thus may vary widely. For therapeutic purposes, the compounds of this invention are ordinarily combined with one or more adjuvants appropriate to the indicated route of administration. If per os, the compounds may be admixed with lactose, sucrose, starch powder, cellulose esters of alkanoic acids, cellulose alkyl esterε, talc, stearic acid, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulphuric acids, gelatin, acacia, sodium alginate, polyvinylpyrrolidone, and/or polyvinyl alcohol, and then tableted or encapsulated for convenient admin¬ istration. Alternatively, the compounds may be dissolved in water, polyethylene glycol, propylene glycol, ethanol, corn oil, cottonseed oil, peanut oil, seεame oil, benzyl alcohol, sodium chloride, and/or variouε buffers. Other adjuvants and modes of admin¬ istration are well and widely known in the pharma- ceutical art. Appropriate dosages, in any given instance, of course depend upon the nature and severity of the condition treated, the route of administration, and the species of mammal involved, including its size and any individual idiosyncrasieε. Representative carriers, diluents and adjuvants include for example, water, lactose, gelatin, starches, magnesium stearate, talc, vegetable oils, gumε, polyalkylene glycols, petroleum jelly, etc. The pharmaceutical compositionε may be made up in a solid form such as granuleε, powderε or εuppoεitorieε or in a liquid form such as solutions, suspensions or emulsionε. The pharmaceutical compositions may be subjected to conventional pharmaceutical operations such as sterilization and/or may contain conventional pharmaceutical adjuvants such as preεervativeε, stabilizerε, wetting agents, emulsifierε, buffers, etc. Dosage levels on the order from about 1 mg to about 100 mg per kilogram of body weight per day are useful in the treatment of the above-indieated conditions (from about 50 mg to about 5 mgε. per patient per day) . For example, inflammation is effectively treated and anti-pyretic and analgesic activity manifested by the administration from about 25 to about 75 mg of the compound per kilogram of body weight per day (about 75 mg to about 3.75 gm per patient per day) . Preferably, from about 5 mg to about 50 mg per kilogram of body weight per daily dosage should produce highly effective resultε (about 250 mg to about 2.5 gm per patient per day). The amount of active ingredient that may be combined with the carrier materialε to produce a - εingle doεage form will vary depending upon the hoεt treated and the particular mode of administration. For example, a formulation intended for oral admini¬ stration to humans may contain from 5 mg to 95 mg of active agent compounded with an appropriate and convenient amount of carrier material which may vary from about 5 to 95 percent of the total composition. Dosage unit forms will generally contain between from about 25 mg to about 500 mg of active ingredient. It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of adminiεtra- tion, route of administration, rate of excretion, drug combination and the severity of the particular disease undergoing therapy. Biological Evaluation Compounds prepared in Example 1, namely, the two isomers IH-[4-(N,N-dicyclopentylcarboxamido)benzyl]- imidazo[4,5-c]pyridine (la) and 3H-[4-(N,N-dicyclopentyl¬ carboxamido)benzyl]imidazo[4,5-c]pyridine (lb), were evaluated in an assay to determine their potency as selective antagonistε of platelet activating factor (l-0-alkyl-2-acetyl-εn-glycero-3-phoεphorylcholine or "AGEPC") which induces aggregation and secretion of [ 3 H] serotonin from labeled, washed rabbit plateletε, by the following procedure: Chemicals: All chemicals and solvents used were reagent grade or better, purchased from Sigma Chemical Co. (St. Louis, MO). Buffers for washing platelets were prepared fresh daily in double-glass- distilled water, as previously described by C.P. Cox et al, Peptides, 5, 25-28 (1984). AGEPC was purchased from Bachem, Inc. (Torrance, CA) and dissolved in phosphate-buffered saline (PBS) containing 2.5 mg/ml bovine serum albumin (BSA). AGEPC Antagonistε: Stock solutions (10 mM) of each of the Example la and lb antagonist compounds were prepared in dimethyl/sulfoxide and diluted in PBS prior to use. Platelet Aggregation and Secretion: Washed, [ 3 H]sero- tonin-labeled rabbit platelets were prepared as deεcribed by C.P. Cox et al, Peptides, 5_, 25-28 (1984), and maintained in an atmosphere of 5% C0 2 at 37°C until used in the bioassay. Aliquots of platelets (2.5 x 10 8 /ml) were incubated with either an antagonist of AGEPC or the appropriate vehicle for 60 seconds prior to the addition of AGEPC (0.2 nM to 0.2 μM) . Aggregation was continuously monitored on a strip-chart recorder and recorded as the height of the tracing at 60 seconds after the addition of AGEPC. Secretion of [ 3 H]serotonin was measured in a sample of the platelet suspension removed at 60 seconds after the addition of AGEPC. The percent inhibition of aggregation and secretion was calculated by comparing antagonist-treated platelets with the appropriate vehicle-treated control platelets. Each combination of antagonist and AGEPC was repeated 12-15 times, using εeveral different platelet preparationε. IC 50 valueε were determined by inspection of the dose-response curves, and are reported below: Compound Secretion (IC K0 ,M) Agqreqation (IC S0 , M) la 14.6 X 10 "9 ID "6 to lO "7 lb 10 "6 to 10 "7 lO "5 to lO "6 2a 9.1 X 10 "9 lo- 7 to lO "8 2b lθ "6 to 10 "7 lO "5 to lO "6 4a 4.8 X 10 "9 lO ""7 to lO "8 4b 10 "6 *to 10 "7 lO "5 to lO "6 5a 8.3 X 10 "9 lO "7 to lO "8 5b 10 "5 to 10 "6 lO '5 to lO "6 6b 10 "6 to 10~ 7 lO "5 to lO "6 Although this invention has been described with respect to specific embodiments, the detailε of these embodiments are not to be construed as limitationε. Various equivalents, changes and modifications may be made without departing from the spirit and scope of this invention, and it is understood that such equivalent embodiments are part of this invention.

Claims: What Iε Claimed Is : 1. A compound of the formula R 4 wherein one of W and X is N and the other of W and X is -CH-; wherein Y iε one or more groupε which may be the same or different attached at one or more of the 2-, 3-, 5- or 6-positions of the phenyl ring, with Y independently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein Z is a group substituted at one of the 3-, 4- or 5-positions of the phenyl ring εaid group provided by with each of R 1 and R 2 independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl and halophenyl; wherein each of R 3 , R 4 and R 5 is independently εelected from hydrido, halo, alkyl and alkoxy; and wherein n is an integer from zero to four; or a pharmaceutically-acceptable salt thereof. 2. Compound of Claim 1 of the formula wherein Y is one or more groups which may be the same or different attached at one or more of the 2-, 3-, 5- or 6-positions of the phenyl ring, with Y independently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercapto¬ alkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 is independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl and halophenyl; wherein each of R 3 and R 4 iε independently εelected from hydrido, halo, alkyl and alkoxy. 3. Compound of Claim 2 wherein Y is independ¬ ently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 is independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl, fluorophenyl, chlorophenyl and bromophenyl; wherein each of R 3 and R 4 is independently selected from hydrido and alkyl; with the proviso that when any of the foregoing substituents contains one or more linear or branched alkyl portions, said alkyl portion has one to about twelve carbon atoms, and that when any of the foregoing substituents contains a cycloalkyl portion, said cycloalkyl portion contains three to about eight carbon atoms. 8653 -34- 4. Compound of Claim 3 wherein Y is independently selected from hydrido, fluoro, chloro, bromo, alkyl, amino, monoalkylamino, dialkylamino and alkoxy; wherein each of R 1 and R 2 is independently selected from branched alkyl, cycloalkyl and alkyl¬ cycloalkyl; and wherein each of R 3 and R 4 is independ¬ ently selected from hydrido and alkyl. 5. Compound of Claim 4 wherein Y is independently selected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, neopentyl, n-hexyl, iso-hexyl, n-heptyl, n-octyl, amino, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino, methoxy, ethoxy, propoxy, methoxymethyl and hydroxy- methyl; wherein each of R 1 and R 2 is independently selected from isopropyl, isobutyl, sec-butyl, tert-butyl, 2-pentyl, 3-pentyl, isopentyl, neopentyl, 2-methylpentyl, 2-hexyl, 3-hexyl, 3-methylpentyl, 4-methylpentyl, 2,2-dimethylpentyl, 2,3-dimethylpentyl, iso-octyl, 2,2,4-dimethylpentyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopentyl and methylcyclohexyl; and wherein each of R 3 and R 4 is independently selected from hydrido, methyl, -ethyl and n-propyl. 6. Compound of Claim 5 wherein Y is one or two groups which may be the same or different attached at one or more positions selected from the two, three, five and six positions of the phenyl ring, with Y independently selected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl, methoxy, amino, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino, methoxymethyl and hydroxymethyl; wherein each of R 1 and R 2 is independently selected from isopropyl, sec-butyl, 2-pentyl, 3-pentyl, 2-hexyl, 3-hexyl, cyclopentyl, methylcyclopentyl, cyclohexyl and methylcyclohexyl; wherein each of R 3 and R 4 is independently selected 7. Compound of Claim 6 wherein Y iε hydrido at all substitutable positions or Y iε one or two groups attached at poεitionε εelected from the two, three, five and six positions of the phenyl ring with Y independently selected from fluoro, methyl and methoxy; wherein each of R 1 and R 2 iε independently εelected from iεopropyl, sec-butyl, cyclopentyl, methylcyclopentyl, cyclohexyl and methylcyclohexyl; and wherein each of R 3 and R 4 iε hydrido. 8. Compound of Claim 7 εelected from the group consisting of lH-[4-(N,N-dicyclopentylcarboxamido)benzyl]imidazo- [4,5-c]pyridine; IH-[4-(N-cyclopentyl-N-cyclohexylcarboxamido)benzyl]- imidazo[4,5-c]pyridine; IH-[4-(N-cyclopentyl-N-3-methylcyclohexylcarboxamido)- benzyl]imidazo[4,5-c]pyridine; IH-[4-(N-2-propyl-N-cyclohexylcarboxamido)-2-methoxy- benzyl]imidazo[4,5-c]pyridine; and IH-[4-(N-2-propyl-N-cyclohexylcarboxamido)benzyl]- [4,5-c]pyridine; and lH-{2-bromo-5-methoxy-4-[(N-cyclopentyl-N-2-methylcyclo- hexyl)carboxamido]benzyl}imidazo[4,5-c]pyridine. 9. A pharmaceutical composition comprising a therapeutically effective amount of a compound and a pharmaceutically-acceptable carrier or diluent, said compound selected from a family of compounds of the formula wherein one of W and X is N and the other of W and X iε -CH-; wherein Y is one or more groups which may be the same or different attached at one or more of the 2-, 3-, 5- or 6-positionε of the phenyl ring, with Y independently εelected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthio lkyl; wherein Z iε a group εubεtituted at one of the 3-, 4- or 5-poεitionε of the phenyl ring εaid group provided by 0 " / --R 1 -CN X R 2 with each of R 1 and R 2 independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl and halophenyl; wherein each of R 3 , R 4 and R s is independently εelected from hydrido, halo, alkyl and alkoxy; and wherein n iε an integer from zero to four; or a pharmaceutically-acceptable εalt thereof. 10. The compoεition of Claim 9 wherein εaid compound iε of the formula wherein Y iε one or more groups which may be the same or different attached at one or more of the 2-, 3-, 5- or 6-positions of the phenyl ring, with Y independently εelected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercapto¬ alkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 is independently εelected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl and halophenyl; wherein each of R 3 and R 4 is independently εelected from hydrido, halo, alkyl and alkoxy. 11. The composition of Claim 10 wherein Y iε independently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 is independently εelected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl, fluorophenyl, chlorophenyl and bromophenyl; wherein each of R 3 and R 4 iε independently εelected from hydrido and alkyl; with the proviso that when any of the foregoing substituents contains one or more linear or branched alkyl portions, said alkyl portion has one to about twelve carbon atoms, and that when any of the foregoing subεtituentε containε a cycloalkyl portion, εaid cycloalkyl portion contains three to about eight carbon atoms. 12. The composition of Claim 11 wherein Y is independently selected from hydrido, fluoro, chloro, bromo, alkyl, amino, monoalkylamino, dialkylamino and alkoxy; wherein each of R 1 and R 2 iε independently selected from branched alkyl, cycloalkyl and alkylcyclo¬ alkyl; and wherein each of R 3 and R 4 iε independently selected from hydrido and alkyl. 13. The composition of Claim 12 wherein Y iε independently selected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, neopentyl, n-hexyl, iεo-hexyl, n-heptyl, n-octyl, amino, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino, methoxy, ethoxy, propoxy, methoxymethyl and hydroxy¬ methyl; wherein each of R 1 and R 2 iε independently εelected from isopropyl, iεobutyl, sec-butyl, tert- butyl, 2-pentyl, 3-pentyl, iεopentyl, neopentyl, 2-methylpentyl, 2-hexyl, 3-hexyl, 3-methylpentyl, 4-methylpentyl, 2 ,2-dimethylpentyl, 2,3-dimethylpentyl, iεo-octyl, 2 , 2,4-dimethylpentyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopentyl and methyl¬ cyclohexyl; and wherein each of R 3 and R 4 iε independ¬ ently εelected from hydrido, methyl, ethyl and n-propyl. 14. The compoεition of Claim 13 wherein Y iε one or two groupε which may be the εame or different attached at one or more positions selected from the two, three, five and six positions of the phenyl ring, with Y independently selected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl, methoxy, amino, N-methylamino, N-ethylamino, N,N- imethylamino, N,N-diethylamino, methoxymethyl and hydroxymethyl; wherein each of R 1 and R 2 iε independently selected from isopropyl, sec-butyl, 2-pentyl, 3-pentyl, 2-hexyl, 3-hexyl, cyclopentyl, methylcyclopentyl, cyclohexyl and methylcyclohexyl; wherein each of R 3 and R 4 is independently selected from hydrido and methyl. 15. The composition of Claim 14 wherein Y is hydrido at all substitutable positionε or Y iε one or two groupε attached at poεitionε εelected from-the two, three, five and six positions of the phenyl ring with Y independently selected from fluoro, methyl and methoxy; wherein each of R 1 and R 2 is independently selected from isopropyl, εec-butyl, cyclopentyl, methylcyclopentyl, cyclohexyl and methylcyclohexyl; and wherein each of R 3 and R 4 is hydrido. 16. The compoεition of Claim 15 wherein εaid compound iε εelected from the group conεiεting of IH-[4-(N,N-dicyclopentylcarboxamido)benzyl]imidazo- [4,5-c]pyridine; IH-[4-(N-cyclopentyl-N-cyclohexylcarboxamido)benzyl]- imidazo[4,5-c]pyridine; lH-[4-(N-cyclopentyl-N-3-methylcyclohexylcarboxamido)- benzyl]imidazo[4,5-c]pyridine; lH-[4-(N-2-propyl-N-cyclohexylcarboxamido)-2-methoxy- benzyl]imidazo[4,5-c]pyridine; IH-[4-(N-2-propyl-N-cyclohexylcarboxamido)benzyl]- [4,5-c]pyridine; and lH-{2-bromo-5-methoxy-4-[(N-cyclopentyl-N-2-methyl- cyclohexyl)carboxamido]benzyl}imidazo[4,5-c]pyridine. 17. A method for treating a diεeaεe attributable to platelet-related pathologies, such aε PAF-stimulated pathologies or platelet-mediated airway hyper-reactivity, in a mammal, which method compriseε treating a εuεceptible mammal with a therapeutically-effective amount of a compound of the formula wherein one of W and X iε N and the other of W and X is -CH-; wherein Y is one or more groups which may be the same or different attached at one or more of the 2-, 3-, 5- or 6-poεitions of the phenyl ring, with Y independently εelected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamine, dialkylamino and alkylthioalkyl; wherein Z is a group substituted at one of the 3-, 4- or 5-positionε of the phenyl ring εaid group provided by with each of R 1 and R 2 independently εelected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl and halophenyl; wherein each of R 3 , R 4 and R 5 iε independently selected from hydrido, halo, alkyl and alkoxy; and wherein n is an integer from zero to four; or a pharmaceutically-acceptable εalt thereof. 18. The method of Claim 17 wherein εaid compound is of the formula wherein Y is one or more groupε which may be the εame or different attached at one or more of the 2-, 3-, 5- or 6-positions of the phenyl ring, with Y independently selected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercapto- alkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 iε independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl and halophenyl; wherein each of R 3 and R 4 is independently selected from hydrido, halo, alkyl and alkoxy. 19. The method of Claim 18 wherein Y is independently εelected from hydrido, hydroxy, fluoro, chloro, bromo, cyano, alkyl, alkoxy, alkylthio, mercaptoalkyl, alkoxyalkyl, hydroxyalkyl, amino, monoalkylamino, dialkylamino and alkylthioalkyl; wherein each of R 1 and R 2 iε independently selected from branched alkyl, cycloalkyl, alkylcycloalkyl, phenyl, alkylphenyl, fluorophenyl, chlorophenyl and bromophenyl; wherein each of R 3 and R 4 is independently selected from hydrido and alkyl; with the proviso that when any of the foregoing εubstituents contains one or more linear or branched alkyl portions, said alkyl portion haε one to about twelve carbon atoms, and that when any of the foregoing subεtituents contains a cycloalkyl portion, said cycloalkyl portion containε three to about eight carbon atomε. 20. The method of Claim 19 wherein Y iε independently εelected from hydrido, fluoro, chloro, bromo, alkyl, amino, monoalkylamino, dialkylamino and alkoxy; wherein each of R 1 and R 2 iε independently selected from branched alkyl, cycloalkyl and alkylcyclo¬ alkyl; and wherein each of R 3 and R 4 is independently εelected from hydrido and alkyl. 21. The method of Claim 20 wherein Y iε independently εelected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl, iεopropyl, butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, neopentyl, n-hexyl, iso-hexyl, n-heptyl, n-octyl, amino, N-methylamino, N-ethylamino, N,N-dimethylamino, N,N-diethy1amino, methoxy, ethoxy, propoxy, methoxymethyl and hydroxy¬ methyl; wherein each of R 1 and R 2 is independently εelected from iεopropyl, iεobutyl, εec-butyl, tert- butyl, 2-pentyl, 3-pentyl, iεopentyl, neopentyl, 2-methylpentyl, 2-hexyl, 3-hexyl, 3-methylpentyl, 4-methylpentyl, 2,2-dimethylpentyl, 2,3-dimethylpentyl, iεo-octyl, 2,2, -dimethylpentyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methylcyclopentyl and methylcyclohexyl; and wherein each of R 3 and R 4 iε independently selected from hydrido, methyl, ethyl and n-propyl. 22. The method of Claim 21 wherein Y is one or two groups which may be the same or different attached at one or more positionε selected from the two, three, five and six positionε of the phenyl ring, with Y independently selected from hydrido, fluoro, bromo, methyl, ethyl, n-propyl and methoxy, amino, N-methy1amino, N-ethylamino, N,N-dimethylamino, N,N-diethylamino, methoxymethyl and hydroxymethyl; wherein each of R 1 and R 2 is independently selected from isopropyl, sec-butyl, 2-pentyl, 3-pentyl, 2-hexyl, 3-hexyl, cyclopentyl, methylcyclopentyl, cyclohexyl and methylcyclohexyl; wherein each of R 3 and R 4 is independently selected from hydrido and methyl. 23. The method of Claim 22 wherein Y is hydrido at all substitutable positionε or Y iε one or two groupε attached at poεitionε εelected from the two, three, five and six positionε of the phenyl ring with Y independently selected from fluoro, methyl and methoxy; wherein each of R 1 and R 2 is independently selected from isopropyl, sec-butyl, cyclopentyl, methylcyclopentyl, cyclohexyl and methylcyclohexyl; and wherein each of R 3 and R 4 is hydrido. 24. The method of Claim 23 wherein said compound is selected from the group consisting of IH-[4-(N,N-dicyclopentylcarboxamido)benzyl]imidazo- [4,5-c]pyridine; IH-[4-(N-cyclopentyl-N-cyclohexylcarboxamido)benzyl]- imidazo[4,5-c]pyridine; IH-[4-(N-cyclopentyl-N-3-methylcyclohexylcarboxamido)- benzyl]imidazo[4,5-c]pyridine; 1H-[4-(N-2-propyl-N-cyclohexylcarboxamido)-2-methoxy- benzyl]imidazo[4,5-c]pyridine; IH-[4-(N-2-propyl-N-cyclohexylcarboxamidoJbenzyl]- [4,5-c]pyridine; and lH-{2-bromo-5-methoxy-4-[(N-cyclopentyl-N-2-methyl- cyclohexyl)carboxamido]benzyl}imidazo[4,5-c]pyridine. 25. The method of Claim 17 wherein εaid diεeaεe is a cardiovascular diεorder, aεthma, lung edema, endotoxin εhock, adult reεpiratory diεtreεε, or an inflammatory diεeaεe.

Inventors: KHANNA ISH K, WEIER RICHARD M, KHANNA, ISH, K., WEIER, RICHARD, M.
Applicants: SEARLE & CO, G.D. SEARLE & CO.
Application year: 1989
Main classification: C07D471
IPC codes: A61K31, A61P9, A61P11, A61P13, A61P15, A61P29, C07D471