Optical examination apparatus

Abstract: An optical examination apparatus for optically examining density, distribution, etc. of oxygen in an object to be examined such as organic tissue like brain tissue, of man or animal a light source (2); and an optical fibre bundle (6) having one end on which light emitted from the light source (2) is incident and which is divided at the other end into a first (61) and second (62) branch with a predetermined ratio of division; a transmitted and scattered light detection means (3) for detecting light which is emitted from the first branch fibre bundle (61) and, in use, is transmitted through and scattered by an object (1) to be examined; a monitoring light detection means (4) for detecting monitoring light emitted from the second branch fibre bundle (62); and, normalization means (5) for normalizing an output of the transmitted and scattered light detection means (3) on the basis of an output from the monitoring light detection means (4). Representative sampling means 602 Figure 1(b), 64 Figure 2(a)) are included to ensure that the light output from the second branch fibre bundle (62) is representative of that output by the light source (2). The presentative sampling means may be provided by distributing the optical fibres (602) forming the second branch fibre bundle uniformly over the one end of the optical fibre bundle. Alternatively they may comprise a mode scrambler (64) interposed between the one end of the optical fibre bundle and the light source to distribute light from the light source over the whole fibre bundle.

Description: The present invention relates to an optical examination apparatus for optically examining density, distribution, etc. of oxygen in an object to be examined such as organic tissue like brain tissue, of man or animal. US-A-4,281,645 discloses one such technique, in which light emitted from a laser light source is led to brain tissue through an optical fibre bundle, and light is transmitted and scattered by the brain tissues. The laser light source emits near infrared light and may operate at a number of different wavelengths and then the measurement is made at every wavelength. However, a laser light source, particularly a semiconductor laser, has a problem in that it is not easy to stabilize its output power and variations in the output power are different at different wavelengths, so that the reliability of the result of examination by means of the examination apparatus is lowered. To overcome this problem we have previously proposed in JP-A-275329/1988 sampling the light output by the light source and using this to normalize the output of the detector which detects the transmitted and scattered light. This arrangement will be described in detail subsequently with reference to the drawings. Whilst this proposal is an improvement there is still problems, particularly in calibrating it for different light output powers and wavelengths. According to this invention an optical examination apparatus comprising a laser light source; an optical fibre bundle having one end on which light emitted from the light source is incident and which is divided at the other end into a first and second branch with a predetermined ratio of division; a transmitted and scattered light detection means for detecting light which is emitted from the first branch fibre bundle and, in use, is transmitted through and scattered by an object to be examined; a monitoring light detection means for detecting monitoring light emitted from the second branch fibre bundle; and, normalization means for normalizing an output of the transmitted and scattered light detection means on the basis of an output from the monitoring light detection means; is characterised by: distributing the optical fibres forming the second branch fibre bundle uniformly over the one end of the optical fibre bundle to ensure that the light output from the second branch fibre bundle is representative of that output by the light source. With the arrangements in accordance with the present invention, in spite of the variations in the luminous pattern of the light source as a result of changes in intensity and wavelength, the light output from the second branch fibre bundle is always representative of the light output of the light source so that the variations in its luminous output can be accurately monitored and compensated for. Particular examples of optical examination apparatus in accordance with this invention will now be described and contrasted with the prior art with reference to the accompanying drawings, in which: Figure 1 is a partly sectioned side elevation ofa main portion of a first example of the present invention; Figure 2 is a cross-section taken along the line A-A shown in Figure 1; Figure 3 is a graph showing the ratio of light output by the first and second branches according to the present invention; Figure 4 is a block diagram showing the arrangement of the whole optical examination apparatus; Figure 5 is a block diagram of the light source and light monitor of an apparatus having a number of different lasers; Figures 6 and 7 are views each showing the arrangement of a light source and an optical fibre bundle in a conventional optical examination apparatus; Figure 8 is a perspective view showing a semiconductor laser and its output pattern; Figures 9(a), (b) and (c) are illustrations of the relationship between the input end of the optical fibre bundle and the output pattern of the light source at three different intensities; and, Figure 10 is a graph showing the ratio of light output by the first and second branches in a conventional apparatus. As shown in Figure 4, an apparatus to measure transmitted and scattered light P A from organic tissues 1 comprises a laser light source 2, a transmitted and scattered light detector 3, a monitoring light detector 4, and a normalizing device 5. The light emitted from the laser light source 2 is incident on an optical-fibre bundle 6 at one end so that the light is partly led to the organic tissues 1 through a first branch fibre bundle 61, and is partly led to the monitoring light detector 4 through a second branch fibre bundle 62. The transmitted and scattered light P A produced from the organic tissues 1 is led to the transmitted and scattered light detector 3 through another optical fibre bundle 7. The respective outputs detected by the transmitted and scattered light detector 3 and the monitoring light detector 4 are transferred in the form of electric signals to the normalizing device 5. In the normalizing device 5, the transmitted and scattered light output S A is normalized in accordance with the monitored light output S M . In the past, when a number of, for example, four, laser light sources 2₁ ∼ 2₄ different in wavelength from each other λ₁ ∼ λ₄) are provided, corresponding number (four) of optical fibre bundles 6₁ ∼ 6₄ are provided as shown in Figure 5. Thus, the output power of the laser light source 2 is monitored and the transmitted and scattered light output S₁ is normalized in accordance with the monitored output power, so that the unevenness due to variations in output in the results of measurement can be compensated once the apparatus is calibrated for all powers and wavelengths. As the optical fibre bundle 6 used in the conventional apparatus those shown in Figures 6 and 7 may be used. Figure 6 shows an optical fibre bundle in which two optical fibres are combined. As shown in the drawing, the laser light emitted from the laser chip 22 fixed to a laser casing 21 is transmitted through a glass window 23. The transmitted light is focused by lenses L₁ and L₂ to be incident on an optical fibre 68 provided at their focus, and then propagated toward the organic tissue 1. On the other hand, another optical fibre 69 is provided adjacent the optical fibre 68, so that laser light displaced from the focus point is incident on that optical fibre 69. Accordingly, if the light propagated through the optical fibre 69 is monitored, the normalization described above can be carried out. Figure 7(a) shows another optical fibre bundle in which a number of optical fibres are combined. As seen in the drawings, the optical fibre bundle 6 is split into a first branch fibre bundle 61 for propagating light to the organic tissues and a second branch fibre bundle 62 for propagating light to the monitored light detector 4. The ends of the plurality of optical fibres constituting the second branch fibre bundle 62 are however unevenly distributed over the end face at a portion inside a coating 63 to one side as represented by the circle shown in Figure 7(b). In the light source 2, particularly when this includes a semiconductor laser however, variations may occur not only in its output power but in its luminous pattern. That is, in such a semiconductor laser 90 as shown in Figure 8, laser light is emitted from a stripe region 92 of an active layer 91 with a luminous pattern 93 having a substantially eliptical shape. We have discovered, as shown in Figure 9, that when the second monitoring branch fibre bundle 62 is located to one side of the optical fibre bundle 6 the overlap between the output and the input ends of the monitoring branch fibre bundle 62 varies. That is, when the luminous pattern 93₁ has a large oval shape as shown in Figure 9(a), the monitoring output is large, but when the luminous pattern 93₃ has a small oval shape as shown in Figure 9(c), the monitoring output is small. Figure 10 shows the ratio between the output characteristic of the monitoring or second branch fibre bundle 62 with respect to that of the first bundle 61. In the drawing, the axis of ordinate shows the output of the first branch fibre bundle 61 for introducing light to organic tissues, and the axis of abscissa shows the output of the second branch fibre bundle 62 for monitoring. The graph illustrates how the measured data is shifted from a linear relationship where the solid line is a regression line of the measured data. Figures 1 and 2 show a main portion of a first example of an examination apparatus in accordance with the present invention which is generally similar to that shown in Figure 4 but in which the optical fibre bundle is replaced by that shown in Figures 1 and 2. This example is different from the conventional optical fibre bundle shown in Figure 7 in that a plurality of optical fibres 602 constituting the second branch fibre bundle 62 for monitoring are distributed uniformly about the incident face and mixed up with the plurality of optical fibres 601 constituting the first branch fibre bundle 61 for light emission. Accordingly, even if a luminous pattern of a laser chip 22 varies with intensity or wavelength, its luminous output is accurately monitored since the second bundle 62 always carries the same proportion of the light incident on the end face. Figure 3 shows the result of measurement by means of the example described above with relative scales. In the drawing, the axis of ordinate indicates the output of the first branch fibre bundle 61 for introducing light to organic tissues, while the axis of abscissa indicates the output of the second branch fibre bundle 62 for monitoring. As shown in the drawing, there is a substantially accurate linear relationship between the outputs with an error not larger than 1%. When the arrangements shown in Figures 1 and 2 are applied to the optical fibre bundle of the optical examination apparatus shown in Figure 4 or 5, even if a semiconductor laser having large variations in its output is used for a light source, the transmitted and scattered light produced from an object to be examined can be compensated so accurately that an extremely accurate result of examination can be obtained. As described above, by providing representative sampling means according to the present invention, in spite of variations in luminous pattern, the laser light can be made incident on the second monitoring branch fibre bundle with a predetermined and constant rate so that variations in luminous output can be accurately monitored. Accordingly, the optical examination can be correctly carried out even in the case where variations occur not only in luminous output of the laser source (for example, a semiconductor laser) but in the luminous pattern of it.

Claims: An optical examination apparatus comprising: a laser light source (2); an optical fibre bundle (6) having one end on which light emitted from the light source (2) is incident and which is divided at the other end into a first (61) and second (62) branch with a predetermined ratio of division; a transmitted and scattered light detection means (3) for detecting light which is emitted from the first branch fibre bundle (61) and, in use, is transmitted through and scattered by an object (1) to be examined; a monitoring light detection means (4) for detecting monitoring light emitted from the second branch fibre bundle (62); and, normalization means (5) for normalizing an output of the transmitted and scattered light detection means (3) on the basis of an output from the monitoring light detection means (4); characterised by distributing the optical fibres (602) forming the second branch fibre bundle (62) uniformly over the one end of the optical fibre bundle (6) to ensure that the light output from the second branch fibre bundle (62) is representative of that output by the light source (2). An optical examination apparatus according to claim 1, in which the light source (2) comprises a number of light sources (2₁-2₄) for emitting light of different wavelength and an optical fibre bundle (60) is provided for light of all the different wavelengths. An optical examination apparatus according to claim 1 or 2, in which the light source (2) is one or more semiconductor lasers. An optical examination apparatus according to any one of the preceding claims, in which light emitted from the light source is in the near infrared region of the electromagnetic spectrum.

Inventors: COPE MARK UNIV COLLEGE LONDON, COPE, MARK UNIV. COLLEGE LONDON DEP. OF MEDICAL
Applicants: HAMAMATSU PHOTONICS KK, HAMAMATSU PHOTONICS K.K.
Application year: 1989
Main classification: A61B5
IPC codes: A61B5, G01N21, G01J3, A61N5, G01J1, A61B10