Process for coloring hair with aminoalkyl or aminohydroxyalkyl catechol compositions

Abstract: A process for coloring hair in which a functional metal ion and aminoalkyl or aminohydroxyalkyl catechols are used in combination or applied sequentially to dye the hair rapidly.

Description: This invention relates to an improved process for dyeing hair on the human scalp or head that utilizes certain aminoalkyl or aminohydroxy alkyl catechols as the essentially sole chromogenic agent with or without color modifiers such as phenylenediamines, nitrobenzenes or similarly used direct dyeing agents common in the art of coloring the hair. More particularly, the invention relates to the use of certain metal ions as catalytic agents for an efficient in situ conversion of said chromogenic agent to melanin-like, durable dyes, whereby certain deficiencies in the procedures previously reported are markedly reduced. The amino alkyl- or amino hydroxyalkyl catechols that are useful for the purposes of this invention are described by the following formula I wherein: (a) R 1 and R 2 are radicals selected from the group consisting of H, OH, alkyl, alkoxy, alkoxyalkyl, NO 2 , COOH and carbalkoxy; (b) R 3 is selected from the group consisting of H, OH, alkyl, alkoxy, alkyoxyalkyl, NO 2 , COOH, carbalkoxy and NH 2 ; (c) R 4 is selected from the group consisting of H,-CH 2 -NHR 5 , CHOHNHR 5 , CH(alkyl)NHR 5 , CH(NHR 2 )NHR 5 , -CH(NO 2 )NHR 5 , - CH(alkoxy)NHR 5 , -CH(aryl)NHR 5 ; -CH(aryloxy)NHR 5 , and -CH(halogen)NHR 5 ; (d) R 5 is selected from the group consisting of H, alkyl and aryl, and wherein at least one of R 3 and R 4 is an amino containing group bonded to a ring carbon atom of the said formula I through a bridging group. The aminoalkyl- or aminohydroxyalkyl catechols that are useful for the purposes of this invention are more particularly described by the following formula II wherein (1) R 6 is H or OH; (2) R 7 is H or alkyl; and (3) n is 0 or 1. When R 7 is alkyl, it is preferably, a lower alkyl radical having from 1 to 4 or 6 carbon atoms. Some literature exists on the possible use of aminoalkylcatechols particularly dopa, as coloring agents for the hair. Typically, an alkaline solution of DOPA is applied to the hair and after 45 to 90 minutes, a dark brown or black (color) is obtained. The characteristics claimed for such treatments are a natural feel and permanent coloring. There are, however, deficiencies in the practical use of this procedure in that alkaline solutions of aminoalkylcatechol are very unstable, requiring them to be prepared freshly before use. Additionally, the dyeout time is too long and severe staining of the skin occurs. The Invention It has now been found that if the hair is treated with a metal salt supplying functional metal ions, satisfactory dyeouts with hair dye compositions containing a compound of formula I above can be obtained in a much shorter period of time than that obtained with the prior art processes. Furthermore, it has been found that this treatment can be accomplished at ambient temperatures (e.g. 20° -35°) which can be readily tolerated by the human scalp and does not require the use of H 2 O 2 as is characteristic of somewhat related processes. In addition, a variety of color hues can be obtained ranging from black to medium or golden brown by suitable modifications in the hair dye composition. Although the precise mechanism of color formation is not known, there is reason to believe that in the presence of metal ions both the binding of the aminoalkyl- or aminohydroxyalkyl catechols to the hair and its subsequent conversion to melanin like durable dyes are favored, thereby the dyeing process is significantly improved. Prior Art A procedure which has been suggested in the prior art for hair dyeing involves the use of an aminoalkyl catechol in a non-alkaline solution containing an oxidizing system. This is exemplified by EP 161073A of 1984 which claims a process of dyeing hair with, e.g., dopamine in a combination containing iodate and a persulfate or periodate. It is said to dye hair pleasing shades of brown and black. However, this requires a treatment that takes over 60 minutes. Soviet Union Patent 566,895 (Fu.Prod.Res.Inst., 1985) describes the use of epinephrine to dye furs dark brown to black. According to this procedure, furs, as distinguished from human hair on the head, are first treated with a metal salt at 1% to 3% weight/weight or a mixture of metal salts for 3 to 6 hours. This is followed by soaking the treated furs from 3 to 6 hours in a bath containing 20% H 2 O 2 and epinephrine. It is obviously prohibitive to dye human hair on the head using such treatment conditions. Moreover, this patent teaches that H 2 O 2 must be used as a second step and it is implied that the coloring process itself would be inoperative without the second step. It was surprising to discover that application of compound I to metal-ion pretreated hair gave a natural looking dyeout in a very short time. In addition, no harsh oxidizing agents such as hydrogen peroxide are required as has been taught in the prior art. U.S. patent 4,453,941 to Jacobs relates to a process for producing pigmentation in hair or on skin. This process involves treating hair with a reaction product of, for example, N-acetyldopamine and an omega amino acid. In column 3 beginning at 47, the patentee describes a process wherein lengths of gray human hair were soaked with a 0.1 M copper chloride solution. The hair is then rinsed and soaked at 25°C with a mixture of 0.01 M N-acetyldopamine and 0.1 M beta-alanine. The hair is said to assume a golden blond color. This disclosure is different from the present invention in several significant respects. In the first place, the N-acetyldopamine employed is not a compound that falls within the definition of the formula I compounds that are useful for the purposes of the present invention. Indeed, N-acetyldopamines are known to undergo indolization reactions very poorly which limits their ability to give melanin-like materials. As a result, under most dyeing conditions, they produce only low intensity dyeouts of light shades. Moreover, the Jacobs patent requires, as a matter of necessity, the inclusion of an amino acid such as beta-alanine in the treatment composition. As a matter of fact, Jacobs goes to great pains to point out that his coloring agent is a reaction product of the N-acetyldopamine and the beta-alanine, this is clearly quite different from the case of the present invention wherein there is no necessity that the compound I components be reacted with a second compound to generate the color producing agent. Japanese patent 50130443 teaches a three step process for coloring hair involving: (a) contacting the hair with a bisulfite solution; (b) treating the hair with a solution containing Cu +2 or Fe +2 ions; and (c) applying a combination of dopamine and a polyhydroxybenzene. Much as in the case with the Jacobs patent, this process relies on the combination of complex reaction products, e.g. dopamine and a polyhydroxy benzene. This is clearly quite different from the present invention, which involves using a compound I material as the color forming agent. Chemical Abstracts, vol 90, 1979; abstract no. 109799b, discloses hair dyes comprising dopa. The composition of the subject patent does not include this compound. Patent abstracts of Japan vol 10, no. 71 (C-334)[2128] dated 20th March 1986 discloses a hair dressing emulsion including dopa. The composition of the subject invention however does not include this compound. Chemical Abstracts, vol 90, 1979 no. 92263x discloses hair dyes comprising dopa. The particular hair dye disclosed also requires essential presence of a pre-treatment agent. DE-A-2 028 818 discloses a method for dyeing human hair wherein the human hair is treated with a pre-treatment preparation comprising an aqueous solution of various specific ions said ions being present in particular concentrations. Subsequently the hair is treated with a dye composition comprising an oxidation dye base and an oxidation formulation. The specified oxidative dyeing system is very different from the dyeing system used in the subject invention. Description of Invention The process of the present invention in its broader aspects as given in claim 1 visualizes that the metal ion and the formula I compound may be applied to the hair either concurrently or sequentially. However, in the preferred mode of practicing the process of this invention these will be applied sequentially, the metal ion being applied to the hair first. To simplify the description of this invention, emphasis will be placed hereinafter on the preferred sequential treatment process. As will be described in more detail below, this sequential treatment also includes the case wherein the metal ion pre-treated hair is dyed with a composition containing both the formula I compound and another metal ion (e.g.. those demonstrated in Examples 13, 15, 16 and 18). As indicated previously, any compound falling within formula I above would be useful in the practice of the present invention. By way of more specific exemplification of such compounds, the following may be mentioned: 3,4-dihydroxyphenylethylamine (Dopamine); epinephrine; 3,4-dihydroxybenzylamine; 2-hydroxy-2-(3,4-dihydroxyphenyl)ethylamine, i.e. The formula I compound will usually be applied to the hair from a hair dye composition containing the same. This hair dye composition will ordinarily take the form of an aqueous composition containing the formula I compound in a concentration sufficient to impart the desired color to the metal ion treated hair. Generally, it will be present in said hair dye composition at a concentration in the range of from 0.1% to 5% by weight based on the total weight of said composition with the preferred range being from 1% to 2% on the same weight basis. One of the advantages of the present invention is that the formula I compound may be applied to hair over a wide range of pH, e.g. from 4 to 10. However, exceptionally good results are obtained with a pH range of 5 to 9, with the preferred range being from 5 to 7. It has been found to be advantageous, although not necessary, to also include an oxidant in the composition used in coloring the metal ion treated hair. When this is the case, an oxidant composition is prepared which will be mixed with the hair dye composition containing the aminoalkyl- or aminohydroxyalkyl catechols just before use to form a hair dye composition now containing the oxidant as well as the aminoalkyl- or aminohydroxyalkyl catechols. Any of a variety of oxidants may be employed for the purposes of the present invention. By way of example, mention may be made of the following: hydrogen peroxide, persulfate (Na or K salt), percarbonates (Ba, Na, or K salts), and periodate (Na or K salts). However, optimum results are obtained when the oxidant is selected from the group consisting of a peroxide (e.g. H 2 O 2 ,benzoyl peroxide, or urea peroxide), an iodate (i.e. IO 3 ), a persulfate, a periodate or combinations thereof. The persulfate or the periodate will usually take the form of their respective alkali metal (e.g. Na, K, Li) or alkaline earth metal (e.g. Ca, Ba, Ti) salts. The oxidant serves to accelerate even further the rate of the color formation beyond the rapid increase already caused by treating the hair with a metal-ion. The concentration of the oxidant contained in the hair dye composition (i.e. the composition formed by mixing the aminoalkyl- or aminohydroxyalkyl catechols composition with the oxidant system) may vary somewhat. Generally the oxidant will be present in said composition at a concentration in the range of from 0.05% to 3% by weight based in the total weight of of the hair dye composition with the preferred range being from 1% to 2% on the same weight basis. The hair dye composition used in the practice of this invention, aside from the formula I compounds may also contain a variety of adjuvants commonly used in the hair dye art to facilitate the dyeing of the hair or that will improve the organoleptic qualities of the composition. For example, dye penetration enhancers, such as phenoxyethanol, benzyl alcohol, isopropanol and others, can be successfully employed. As used herein the term "hair dye composition" refers both to the simple formula I compound compositions and to the simple formula I compound compositions to which have been added the oxidant compositions. Accordingly, the final composition employed in practicing the process of this invention may also contain the adjuvants present in the simple aminoalkyl- or aminohydroxyalkyl catechols composition or the adjuvants contained in both the simple aminoalkyl- or aminohydroxyalkyl catechols composition and in the oxidant system. As indicated above it is a feature of the present invention to contact the hair on the head of a subject with at least one metal salt that provides functioning metal ions prior to subjecting said hair to the hair dyeing operation with a composition containing a formula I compound. As used herein the term "functioning metal ions" means any metal ion which accelerates the formation of melanin-like materials from the aminoalkyl- or aminohydroxyalkyl catechols. Salts of any of a variety of metals, which are preferably water soluble, may be employed for this purpose. By way of example of the metallic moieties of the salts that may be used in accordance with the present process the following may be mentioned: copper (e.g. Cu +2 ), titanium (e.g. Ti +2 ) , zinc (e.g. Zn +2 ), iron (e.g. Fe +2 and Fe +3 ) nickel (e.g. Ni +2 ), cobalt (e.g. Co +2 ), lead (e.g. Pb +2 ), silver (e.g. Ag +1 ) and manganese (e.g. Mn +2 ). All of these metal ions given by way of illustration are capable of assisting the conversion of formula I compounds to melanin-like materials. However, this list is not exhaustive of the metal salts that can be employed herein and is not intended to exclude or limit the scope of such metal ions that are useful in this hair coloring process. The anionic moieties of these salts may be exemplified by such anions as sulfate, lactate, tartrate, acetate, citrate, nitrate and chloride. Again, this listing is not exhaustive of those anions of the metal salts employable in this invention. By way of illustration of specific salts which may be used in the pre-treatment of hair according to the present invention the following salts may be mentioned CuSO 4 , Ti(lactate) 2 , Fe(NO 2 ) 3 , FeSO 4 , K 3 Fe(CN) 6 , Pb(acetate) 2 , Cu(II) (Citrate), ZnSO 4 , NiSO 4 , Co(acetate) 2 , Ag(Nitrate), Mn(nitrate) 2 , and Mn(Cl) 2 . The salts used in accordance with the present invention will ordinarily be applied to the hair from a composition containing the same which will usually be an aqueous composition. The concentration of the metal salt contained in this composition will vary somewhat, but generally will fall into the range of from 0.001% to 2% by weight based on the total weight of the metal salt composition, with the preferred range being from 0.01% to 1% on the same weight basis. A convenient way of applying the metal salt is from a shampoo composition. In this event the metal salt composition in addition to detergents will also contain the adjuvants found in shampoo compositions. These include such items as amides, fafty acids, cocamidopropyl betaine, fragrance, preservatives, etc. In carrying out the process of the present invention the hair on the human head is contacted with a metal salt containing composition as described above. Typically the metal salt concentration will be in the range from .001% to 5%. This composition is allowed to remain in contact with the hair for a period of from 1 minute to 45 minutes; preferably from 5 minutes to 15 minutes. The hair can then be shampooed. This process will ordinarily be carried out at room temperatures although elevated temperatures may be employed, such as those which can be achieved with commercial hair dryers. Following the treatment with the aforesaid metal salts the hair is contacted with a solution of the formula I compound (e.g. .05% to 2% solution). The pH of this composition may vary but typically it will be in the range of from 5 to 7. The length or duration of application may vary somewhat depending on the results desired. Usually, however, this will be in the range of from 5 to 15 to 30 minutes. Dyeing may be accomplished at any of a variety of temperatures. Preferably temperatures will be close to room temperatures (e.g. from 20°C to 35°C). However, under some circumstances it may be advantageous to carry out this procedure at an elevated temperature, for example that achieved with commercial hair dryers. In some cases, it may be desirable to mix the metal salt with a formula I compound and use this mixture to treat hair that has been previously treated with a metal salt. Thus, for example, an Fe ++ salt may be mixed with epinephrine to form a solution having a pH from 5 to 7. This composition may be used to dye hair that has been previously treated with a Cu ++ or Fe +3 salt. Treatment of the latter kind for a period of 20 to 30 minutes gives a medium golden brown dyeout. The significant advantage to this method is the lack of any added oxidant or potential oxidant such as IO 3 , or persulfate. Thus, whereas it is desirable to use an oxidant in the presence of a metal-salt already applied to the hair, in certain instances the aminoalkyl- or aminohydroxyalkyl catechols conversion to a melanin does not require such oxidant and the combination of metal-salts suffice. Alternatively the formula I compound solution may be mixed, for example, with 0.1 to 3% of an oxidant such as peroxide (e.g. hydrogen peroxide, benzoyl peroxide, or urea peroxide), persulfate (as the sodium or potassium salt), or a perhalite (e.g. periodate, perchlorate, or perborate) immediately prior to application to hair previously treated with a metal salt. This gives a light medium brown dyeout typically in less than 20 minutes. As in the other procedure, the dyeout is preferably performed at room temperatures (i.e. 20°C to 35°C). Although in some cases this may be done at elevated temperatures as, for example, that achieved with a commercial hair dryer. When the hair dye composition employed contains both an aminoalkyl- or aminohydroxyalkyl catechol and an oxidant this will generally be prepared first prior to the application to the hair. In this case a dye concentrate containing an aminoalkyl- or aminohydroxyalkyl catechol will be mixed with an oxidizing composition containing one or more oxidants to obtain the hair colorant formulation. The dye concentrate employed will contain an aminoalkyl- or aminohydroxyalkyl catechols in the concentration range of from 0.1% to 5% by weight based on the total weight of the dye concentrate with the preferred concentration following in the range of from 1% to 2% on the same bases. The oxidizing composition, on the other hand, will contain the oxidant component or components in a concentration in the range of from 1% to 6% by weight based on the total weight. In this case the preferred concentration range is from 1% to 2% by weight based on the total weight of the oxidizing composition. To prepare the hair colorant formulation, i.e. the composition containing both an aminoalkyl- or aminohydroxyalkyl catechol and one or more oxidants, from 0.5 to 2 parts by weight of the oxidizing composition per part of dye concentrate will be mixed with each other just prior to use. The colors obtained on hair from the exposure of metal salt pre-treated hair to an aminoalkyl- or aminohydroxyalkyl catechol composition with or without an oxidant range from light to brown to black. It is sometimes advantageous to lighten the dark dyeouts to a golden brown or a dark brown. This may be accomplished, in accordance with the present invention, by a post-treatment of the hair dyed as described above with an oxidizing agent, such as an aqueous H 2 O 2 solution in which the concentration of the H 2 O 2 in said solution is in the range of 0.1% to 6% by weight based on the total weight of the aqueous composition and having an alkaline pH (e.g., pH 9 has been found to be quite suitable). The hair is quickly lightened by saturating said aminoalkyl- or aminohydroxyalkyl catechols dyed metal salt treated hair with this oxidizing solution for 5 minutes to 10 minutes and then rinsing the hair. The following example sets forth a general procedure for dyeing hair with a process of metal-salt embrocation and the sequential treatment with an aminoalkyl- or aminohydroxyalkyl catechol. Following this example is Table 1 which details various metal-salt, aminoalkyl- or aminohydroxyalkyl catechols and buffer solutions found to be useful. Next listed is Table II which further exemplifies the breadth of dyeout colors achievable. General Example of Hair Dyeing . Solution A is made up by dissolving 2% dopamine (wt/wt) (i.e. 3,4-dihydroxyphenyethylamine) at pH 7 in buffered water containing 1% (wt/wt) of iodate (IO 3 , either the sodium or potassium salt). Next a metal-salt solution is made by dissolving 0.04 M copper sulfate in a solution of 1% monoethanolamine (vol/vol) in water and then treating blended grey hair in this solution for 5 minutes. The hair is then rinsed with water and patted dry. Next the hair swatch is treated in solution A for 15 minutes to give a of dark brown dyeout with yellow hues. The prior art which does not use a metal ion requires 45 to 90 minutes to obtain dark grey to black dyeouts. Other useful compositions are set out in Table I. These compositions were used in procedures which were substantially similar to that described above, except that the reagents and other parameters used were those listed in the table. Table II sets forth another set of reagents. The metal-salt solutions were applied for about five minutes. The aminoalkyl- or aminohydroxyalkyl catechols were applied for about 10 minutes. The resultant colors are given in the tables. The Hair Dyed as per Examples in Table II Was Lightened By Treating the Dyed Swatches with 3% H 2 O 2 At pH9 (monoethanolamine buffered) For 5 Minutes. All Tresses were Originally Composed of Natural Blended Gray Hairs The Results Are Given in Table III Metal-Ion/Substituted Catechol Combination; pH Dyeout Color Before Bleaching Dyeout color After Bleaching Ex. 18 Dark Brown with Yellow Hues Light Golden Brown Cu +2 pretreatment/1% Dopamine + 1% IO 3 at pH 7 Ex. 19 Medium Golden Brown Light Golden Brown Ti +2 pretreatment/1% Dopamine + 1% IO at pH 7 Ex. 20 Dark Brown with Blue Highlights Light Golden Brown Zn +2 pretreatment/1% Dopamine + 1% IO 3 at pH7 Ex. 21 Medium Brown Straw Colored Fe(CN) 6 -3 pretreatment/1% Epinephrine + 1% Fe +2 at pH 6 Ex. 22 Dark Golden Brown Lustrous Golden Brown Fe +2 pretreatment/1% Epinephrine + 1% Fe(CN) 6 -3 at pH 6

Claims: A process for coloring hair on a live human head which comprises treating said hair with only one melanin-like material-forming composition consisting of one or more metal salts capable of assisting the conversion of a catechol compound to a melanin-like material and at least one aminoalkyl or aminohydroxyalkyl-catechol having the formula I set out below wherein: (a) R 1 and R 2 are radicals selected from the group consisting of H, OH, alkyl, alkoxy, alkoxyalkyl, NO 2 , COOH and carbalkoxy; (b) R 3 is selected from the group consisting of H, OH, alkyl, alkoxy, alkyoxyalkyl, NO 2 , COOH, carbalkoxy and NH 2 ; (c) R 4 is selected from the group consisting of H,-CH 2 -NHR 5 , CHOHNHR 5 , CH(alkyl)NHR 5 , CH-(NHR 2 )NHR 5 , -CH(NO 2 )NHR 5 , - CH(alkoxy)NHR 5 , -CH(aryl)NHR 5 ; -CH(aryloxy)NHR 5 , and -CH(halogen)NHR 5 ; (d) R 5 is selected from the group consisting of H, alkyl and aryl, and wherein at least one of R 3 and R 4 is an amino containing group bonded to a ring carbon atom of the said formula I through a bridging group, and further provided that the process does not include treatment with the following compositions 〈1 ○〉, 〈2 ○〉 and 〈3 ○〉. 1 ○ % w/w Sodium lauryl sulphate 40.00 Cocamidopropyl betaine 10.00 Iron (II) ammonium sulphate 1.00 Copper sulphate 0.20 Thiourea 0.10 Disodium edetate 0.10 Perfume 0.50 Sodium chloride 9.50 Kathon C.G. (preservative) 0.10 Water to 100.00% 2 ○ % w/w Magnesium lauryl sulphate 40.00 Cocamidopropyl betaine 10.00 Kathon C.G. 0.10 Disodium edetate 0.30 Iron (II) ammonium sulphate 1.00 Ascorbic acid 0.10 Urea 0.10 Ammonia solution (0.28% solution) 0.75 Hexylene glycol 2.30 Perfume q.s. Deionized water to 100.00% 3 ○ % w/w Magnesium lauryl sulphate 40.00 Cocamidopropyl betaine 5.00 Kathon C.G. 0.10 Disodium edetate 0.30 Iron (II) ammonium sulphate 1.00 Vitamin E acetate 0.10 Magnesium chloride 0.5 Perfume q.s. Deionized water to 100.00% The process according to claim 1 wherein said metal salt and said aminoalkyl or aminohydroxyalkyl catechol are applied concurrently. The process according to claim 1 wherein said metal salt and said aminoalkyl or aminohydroxyalkyl-catechol are applied sequentially. The process according to claim 3 in which said metal salt is first applied to the hair to form a metal ion deposit on the hair which is followed by an application of the aminoalkyl or aminohydroxyalkyl-catechol. The process according to claim 4 wherein said composition containing said aminoalkyl or aminohydroxyalkyl catechol also contains a metal salt. The process according to claim 5 wherein said metal salt is selected from the group consisting of an iodate, a persulfate, a periodate and combination thereof. The process according to any preceding claim including the step of post-treating hair colored in accordance therewith with an aqueous composition of hydrogen peroxide. A process according to claim 4 where said metal salt is present in said first composition in the concentration of from 0.001% to 2% by weight based on the total weight of said first composition and said aminohydroxy or aminohydroxyalkyl-catechol is present in said second composition in the concentration in the range of from 0.05% to 2% by weight based on the total weight of said second composition. The process according to claim 8 wherein said second composition also contains an oxidant at a concentration in the range of from 0.05% to 3% by weight based on the total weight of said second composition. The process according to any preceding claim wherein said catechol is selected from the group consisting of: epinephrine, 3,4-dihydroxy phenylethylamine, 2-hydroxy-(3,4-dihydroxyphenyl)-ethylamine,3,4-hydroxybenzyl-amine, and mixtures thereof. The process of claim 4 wherein the metallic moiety in the metal salt is at least one of copper, titanium, zinc, iron, nickel, cobalt, lead, silver and manganese. The process according to any one of preceding claims 1-9 and 11 wherein the catechol compound is of the formula: wherein R 6 is H or OH ; R 7 is H or alkyl; and n is o or 1 .

Inventors: BROWN KEITH CHARLES, PROTA GIUSEPPE, SCHULTZ THOMAS M, WOLFRAM LESZEK J, BROWN, KEITH CHARLES, PROTA, GIUSEPPE, SCHULTZ, THOMAS M., WOLFRAM, LESZEK J.
Applicants: SQUIBB BRISTOL MYERS CO, BRISTOL-MYERS SQUIBB COMPANY
Application year: 1989
Main classification: A61K7
IPC codes: A61K8, A61Q5, D06P3