ORAL COMPOSITION

Abstract: The present invention relates to oral compositions such as dentifrices or mouthwashes. By inclusion therein of a shorter chain mono- and dialkylphosphate as surfactant, a mild product is obtained which also has improved anti-caries properties. Preferred are sodium mono- and di-octyl phosphates for use in these compositions.

Description: BACKGROUND TO THE INVENTION The invention relates to aqueous compositions suitable for use in oral hygiene, especially for cleaning the mouth and the teeth. In particular, the invention is concerned with highly improved detergent compositions suitable for use as dentifrices and mouth washes. The damaging effect of conventional detergents used to cleanse the mucosae, particularly the mouth, has been the subject of intense study for many years in a search for mild products, which not only cleanse efficiently, but also leave the mouth and teeth with a pleasant after feel, without irritation or other chemical damage to the gums or mucosae. We have now discovered quite unexpectedly, that by selection of a specific dialkyl phosphate in the form of a salt, together with a monoalkyl phosphate salt to modify the foam characteristics of the product, a composition can be obtained which in use is capable of producing superior foam characteristics and cleaning power, that cannot be matched by any other product. Furthermore, the composition is so mild that it can safely be used for cleansing the teeth and mucosae, including the gums when diseased or damaged. It is particularly useful for cleaning sensitive gums, for example when gingivitis is present, and also prossesses improved anti-caries properties. Also, following use of the composition in the mouth, the taste of foods and drinks subsequently consumed is not changed, in contrast to the bitter after-taste that can result when more conventional surfactants are employed. DEFINITION OF THE INVENTION Accordingly, the invention provides an aqueous composition suitable for use as a dentifrice and mouthwash which comprises: (a) a monoalkyl or monoalkenyl phosphate salt (or mixtures thereof) having the structure: (b) a dialkyl or dialkenyl phosphate salt (or mixtures thereof) having the structure: and optionally: (c) a dialkyl or dialkenyl phosphate salt having the structure: where R¹ is the same or different and is chosen from saturated or unsaturated, branched or unbranched alkyl or alkenyl groups having an average of from 6 to 9 carbon atoms, and R² is chosen from alkyl or alkenyl groups having an average of from 6 to 18 carbon atoms, R³ is chosen from alkyl or alkenyl groups having an average of from 10 to 18 carbon atoms, and X is chosen from sodium, potassium, ammonium, substituted ammonium and alkylolamine. DISCLOSURE OF THE INVENTION The mono-alkyl or monoalkenyl phosphate salt The composition according to the invention comprises a monoalkyl or monoalkenyl phosphate salt (or mixtures thereof) which is intended to modify the foam characteristics and the after-use feel of the composition in the mouth. The monoalkyl or monoalkenyl phosphate salt has the structure: where R² is chosen from alkyl or alkenyl groups having an average of from 6 to 18 carbon atoms, and X is chosen from sodium, potassium, ammonium, substituted ammonium and alkanolamine. The preferred monoalkyl phosphate salts are sodium monolauryl phosphate, triethanolamine monolauryl phosphate, and sodium monooctyl phosphate. The amount of monoalkyl or monoalkenyl phosphate salt present in the composition of the invention is from 0.1, conveniently from 1 to 95%, preferably from 2 to 90% by weight. The Shorter Chain Dialkyl or Dialkenyl Phosphate Salt The composition according to the invention also comprises a dialkyl or dialkenyl phosphate salt (or mixtures thereof) having the structure: where R¹ is the same or different and is chosen from saturated or unsaturated, branched or unbranched alkyl or alkenyl groups having an average of from 6 to 9 carbon atoms, and X is chosen from sodium, potassium, ammonium, substituted ammonium and alkylolamine. The preferred shorter chain dialkyl phosphate is dioctyl phosphate and the preferred salts are sodium and alkylolamine salts, particularly the triethanolamine salt. The amount of the shorter chain alkyl or dialkenyl phosphate salt present in the composition of the invention is from 0.1, conveniently from 1 to 95%, preferably from 5 to 90% by weight. The Longer Chain Dialkyl or Dialkenyl Phosphate Salt The composition according to the invention can also optionally comprise a dialkyl or dialkenyl phosphate salt (or mixtures thereof) having the structure: where R³ is chosen from alkyl or alkenyl groups having an average of from 10 to 18 carbon atoms, and X is chosen from sodium, potassium, ammonium substituted ammonium and alkanolamine. The preferred longer chain dialkyl phosphate salts, when present, are sodium dimyristyl phosphate and triethanolamine lauryl phosphate. The amount of the longer chain dialkyl or dialkenyl phosphate salt, when present, is up to 50%, usually from 0.1 to 50%, preferably from 1 to 20% by weight of the composition. The weight ratio of the monoalkyl or monoalkenyl phosphate salt to the longer chain dialkyl phosphate or dialkenyl salt is from 100:0 to 50:50, preferably 99:1 to 75:25. Dentifrice and/of Mouthwash adjuncts The composition according to the invention will also comprise adjuncts, that is other ingredients, conventionally employed in dentifrice and mouthwash formulations. Examples of these adjuncts include: Polishing agents (or abrasive agents), such as silicas, calcium hydrogenphosphate, calcium carbonate, calcium pyrophosphate, calcium hydroxyapatite and alumina; Binders such as sodium carboxymethylcellulose, hydroxyethylcellulose, carrageenan, sodium alginate, gum arabic, xanthan gum, montmorillonite and hectorite; Humectants, such as glycerin and sorbitol; Therapeutic agents, such as organic antimicrobial agents; metal ions, including zinc, copper, tin and strontium, fluoride sources, such as sodium monofluorophosphate, sodium fluoride, stannous fluoride and amine fluorides; agents promoting the delivery of therapeutic agents such as polyvinylmethylether-maleic anhydride copolymers. Antitartar agents, such as sodium and potassium pyrophosphate; anti-microbial agents such as 2,4,4′ trichloro-2′-hydroxy-diphenylether (Triclosan); Other surfactants, such as sodium lauryl sulphate and dodecylbenzene sulphonate; Sweetening agents, such as soluble saccharin and Candarel; and flavouring agents such as oil of wintergreen, peppermint oil, spearmint oil and menthol. The amount of dentifrice and/or mouthwash adjuncts to be incorporated in compositions according to the invention will be those conventionally employed in these products. By way of example, it can be stated that a dentifrice can contain the following ingredients in the amounts stated: In the above example, the amount of monoalkyl phosphate salt and dialkyl phosphate salt, as herein defined, can conveniently be from 0.2 to 5% by weight of the composition. The preferred mixture of monoalkyl and dialkylphosphates is a mixture of mono octyl and dioctylphosphate. Water The composition according to the invention also comprises an amount of water to act as a vehicle for the phosphate salts and other ingredients, to enable them to be provided at a concentration suitable for use as a dentifrice or mouthwash. The amount of water present in the composition of the invention is accordingly from 10 to 99%, preferably from 15 to 90% by weight of the composition. Co-surfactant The composition according to the invention can also optionally comprise a co-surfactant, further to modify the surfactant properties of the dialkyl or dialkenyl salt. Examples of co-surfactants includes anionic surfactants other than the phosphate salts defined herein, as well as nonionic, amphoteric and zwitterionic surfactants. Particularly preferred examples of amphoteric surfactants include amidoamine surfactants having the structure: or where R⁷ is chosen from saturated or unsaturated alkyl groups having an average of from 7 to 19 carbon atoms; and X² is chosen from hydrogen, sodium, potassium, ammonium, substituted ammonium and alkanolamine. Specific examples of amidoamine surfactants include those in which R⁷ is represented by lauryl or myristyl and X² is represented by sodium or triethanolamine. Particularly preferred examples of zwitterionic surfactants include hydroxysulphobetaines having the structure: where R⁸ is chosen from saturated or unsaturated alkyl groups having from 8 to 18 carbon atoms; and R⁹ is the same or different and is chosen from alkyl groups having 1 or 2 carbons atoms. Specific examples of hydroxysulphobetaines include: lauryldimethyl hydroxysulphobetaines, and lauryldiethyl hydroxysulphobetaine. The amount of co-surfactant when present in the compositions according to the invention is usually up to 50%, preferably from 1 to 40% by weight. PRODUCT FORM OF THE COMPOSITION The composition according to the invention can take the form of a liquid, gel, paste or cream, intended to be dispensed from a capped container such as a bottle, tube, or a pump-operated dispenser. EXAMPLES The invention is further illustrated by reference to the following example. Example 1 This Example illustrates a dentifrice. The dentifrice contained the following ingredients: Example 2 This Example illustrates further dentifrice formulations according to the invention Example 3 An experiment was carried out in which the effect of a 1% DOP* solution was evaluated as a potential anticaries agent by its ability to reduce the demineralisation of dental enamel in-vitro. The method of Page was used (J. Dent. Res. 68 (1989) 587) and four treatments were tested, Placebo (Water), 1% SLS (= sodium lauryl sulphate), 1% DOP and a 1 ppm Fluoride Solution (as Sodium Fluoride), a known anticaries agent (positive control). The results are shown in the table below for a study on six teeth: The mean Calcium Demineralisation Rates and % Reduction in Demineralisation are calculated using the following formulae. Calcium Demineralisation Rate = Calcium in Solution (Time in Acid) x (Area of Exposed Enamel) The SLS treatment numerically showed a difference to the placebo (water) treatment but this was not satistically significant at the α= 0.01 level (Duncan's Multiple Range Test). Both the fluoride (positive control) and the DOP treatment reduced the rate of enamel demineralisation significantly (α = 0.01 level) in the test with the DOP treatment showing the greatest effect. The DOP treatment was satistically significantly better than the fluoride treatment in this test. This experiment shows that DOP has potential anticaries activities, as it is able to protect dental enamel from demineralisation when exposed to acidic solutions. Example 4 In a panel test in which the effect of surfactants in mouthwashes on the perception of orange juice was assessed, no difference was found between 1% SLS or 1% DOP, on bitterness, sharpness and freshness, but the following improvements of DOP over SLS were perceived: orange taste + 31% sweetness + 41% drying + 59% smooth teeth + 37%

Claims: An aqueous composition suitable for use as a dentifrice and mouthwash which comprises: (a) from 0.1 to 95% by weight of a monoalkyl or monoalkenyl phosphate salt or mixtures thereof having the structure: (b) from 0.1 to 95% by weight of a dialkyl or dialkenyl phosphate salt or mixture thereof having the structure: and from 0 to 50% by weight of (c) a dialkyl or dialkenyl phosphate salt having the structure: where R¹ is the same or different and is chosen from saturated or unsaturated, branched or unbranched alkyl or alkenyl groups having an average of from 6 to 9 carbon atoms, and R² is chosen from alkyl or alkenyl groups having an average of from 6 to 18 carbon atoms. R³ is chosen from alkyl or alkenyl groups having an average of from 10 to 18 carbon atoms, and X is chosen from sodium, potassium, ammonium, substituted ammonium and alkylolamine. A composition according to claim 1, wherein R¹ and R² are octyl.

Inventors: CARTER, PETER, HAMMOND, KEVIN
Applicants: UNILEVER N.V., UNILEVER PLC
Application year: 1989
Main classification: A61K7
IPC codes: A61K8, A61Q11