NEW INDOLYLPIPERIDINE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Abstract: The present invention relates to new indolylpiperidine compounds represented by the following general formula (I): wherein R¹ is aryl substituted with substituent(s) selected from the group consisting of hydroxy, protected hydroxy, halogen and lower alkoxy, A is lower alkylene, and B is lower alkenylene processes for the preparation thereof and pharmaceutical composition comprising the same.

Description: This invention relates to new indolylpiperidine compounds and pharmaceutically acceptable salts thereof. More particularly, it relates to new indolylpiperidine compounds and pharmaceutically acceptable salt thereof which have antiallergic activity, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of allergic disease in human beings or animals. One object of this invention is to provide new indolylpiperidine compounds and pharmaceutically acceptable salts thereof which possess antiallergic activity. Another object of this invention is to provide processes for the preparation of said indolylpiperidine compounds or salts thereof. A further object of this invention is to provide a pharmaceutical composition comprising, as an active ingredient, said indolylpiperidine compounds or pharmaceutically acceptable salts thereof. Still further object of this invention is to provide a therapeutical method for the treatment of allergic disease such as allergic asthma, allergic rhinitis, allergic conjunctivitis, chronic urticaria in human beings or animals. Some indolylpiperidine compounds having anti-allergic activity have been known as described in British Patent Application Publication No. 2093455. Some amide derivatives having anti-allergic activity have been known as described in European Patent Application Publication No. 157420. The object indolylpiperidine compounds of this invention are new and can be represented by the following general formula [I] : wherein R¹ is phenyl substituted with substituent(s) selected from the group consisting of hydroxy, C₁-C₆ alkoxy(C₁-C₆)alkoxy-(C₁-C₆)alkoxy, C₁-C₆ alkyl, C₁-C₆ alkanoyloxy, C₁-C₆ alkoxycarbonyloxy, halogen and C₁-C₆ alkoxy, A is C₁-C₆ alkylene, and B is vinylene, propenylene, butenylene, pentenylene, butadienylene or pentadienylene. The object compound [I] or its salt can be prepared by processes as illustrated in the following reaction schemes. Process 1 Process 2 Process 3 wherein R 1 / a is phenyl substituted with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and halogen, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkyl, or with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkoxy, R 1 / b is phenyl substituted with hydroxy, with hydroxy and halogen, with hydroxy and C₁-C₆ alkyl, or with hydroxy and C₁-C₆ alkoxy, R 1 / c is phenyl substituted with hydroxy, or with hydroxy and C₁-C₆ alkoxy, R 1 / d is phenyl substituted with C₁-C₆ alkoxycarbonyloxy, or with acyloxy selected from C₁-C₆ alkanoyloxy and C₁-C₆ alkoxycarbonyloxy and C₁-C₆ alkoxy, and R¹, A and B are each as defined above. In the above and subsequent descriptions of the present specification, suitable examples of the various definitions to be included within the scope of the invention are explained in detail in the following. Suitable "C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy" may be methoxyethoxymethoxy. Suitable "C₁-C₆ alkanoyloxy" may be formyloxy, acetyloxy, propionyloxy, butyryloxy, isobutyryloxy, valeryloxy, isovaleryloxy, pivaloyloxy, hexanoyloxy, 3,3-dimethylbutyryloxy. Suitable "C₁-C₆ alkoxycarbonyloxy" may be methoxycarbonyloxy, ethoxycarbonyloxy, propoxycarbonyloxy, isopropoxycarbonyloxy, butoxycarbonyloxy, isobutoxycarbonyloxy, tert-butoxycarbonyloxy, pentyloxycarbonyloxy, hexyloxycarbonyloxy. Suitable "halogen" is fluorine, chlorine, bromine and iodine. Suitable "acyloxy" may be selected from C₁-C₆ alkanoyloxy and C₁-C₆ alkoxycarbonyloxy as above-mentioned. Suitable "C₁-C₆ alkoxy" may be a straight or branched one such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, tert-butoxy, pentyloxy, hexyloxy in which the preferable one is C₁-C₄ alkoxy and the most preferable one is methoxy. Preferable example of "phenyl substituted with substituent(s) selected from the group consisting of hydroxy, C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, C₁-C₆ alkyl, C₁-C₆ alkanoyloxy, C₁-C₆ alkoxycarbonyloxy, halogen and C₁-C₆ alkoxy" may be mono-, or di-, or trihydroxyphenyl; mono-, or di-, or tri(halo)phenyl [e.g. chlorophenyl, fluorophenyl, dichlorophenyl, trifluorophenyl]; mono-, or di-, or tri(C₁-C₆)alkylphenyl [e.g. tolyl, mesityl, cumenyl, xylyl, ethylphenyl, diethylphenyl, isopropylphenyl, diisopropylphenyl, di-tert-butylphenyl]; mono-, or di-, or tri(C₁-C₆)alkoxyphenyl [e.g. methoxyphenyl, ethoxyphenyl, dimethoxyphenyl, trimethoxyphenyl, diethoxyphenyl, diisopropoxyphenyl]; mono-, or dihydroxy and mono-, or di(C₁-C₆)alkoxy substituted phenyl [e.g. methoxy(hydroxy)phenyl, ethoxy(hydroxy)phenyl, isopropoxy(hydroxy)phenyl, dimethoxy(hydroxy)phenyl, diethoxy(hydroxy)phenyl, diisopropoxy(hydroxy)phenyl, methoxy(dihydroxy)phenyl, methoxy(ethoxy)hydroxyphenyl]; mono-, or dihydroxy and mono-, or di(C₁-C₆)alkyl substituted phenyl [e.g. methyl(hydroxy)phenyl, ethyl(hydroxy)phenyl, propyl(hydroxy)phenyl, isopropyl(hydroxy)phenyl, dimethyl(hydroxy)phenyl, diethyl(hydroxy)phenyl, diisopropyl(hydroxy)phenyl, di-tert-butyl(hydroxy)phenyl, methyl(dihydroxy)phenyl, methyl(ethyl)hydroxyphenyl]; mono-, or dihydroxy and mono-, or dihalo substituted phenyl [e.g. chloro(hydroxy)phenyl, dichloro(hydroxy)phenyl, fluoro(hydroxy)phenyl, chloro(dihydroxy)phenyl]; mono-, or di-, or tri[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy]phenyl [e.g. mono-, or di-, or tri(methoxyethoxymethoxy)phenyl]; mono-, or di-, or tri(C₁-C₆)alkanoyloxyphenyl [e.g. formyloxyphenyl, acetyloxyphenyl, propionyloxyphenyl, diacetyloxyphenyl, dipropionyloxyphenyl, triacetyloxyphenyl]; mono-, or di-, or tri(C₁-C₆)alkoxycarbonyloxyphenyl [e.g. methoxycarbonyloxyphenyl, ethoxycarbonyloxyphenyl, diethoxycarbonyloxyphenyl, triethoxycarbonyloxyphenyl]; mono-, or di(C₁-C₆)alkoxy and mono-, or di[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy]substituted phenyl [e.g. methoxy(methoxyethoxymethoxy)phenyl, ethoxy(methoxyethoxymethoxy)phenyl, dimethoxy(methoxyethoxymethoxy)phenyl, diethoxy(methoxyethoxymethoxy)phenyl, diisopropoxy(methoxyethoxymethoxy)phenyl]; mono-, or di(C₁-C₆)alkanoyloxy and mono-, or di(C₁-C₆)alkoxy substituted phenyl [e.g. acetyloxy(methoxy)phenyl, propionyloxy(methoxy)phenyl, acetyloxy(ethoxy)phenyl, acetyloxy(dimethoxy)phenyl, propionyloxy(dimethoxy)phenyl, acetyloxy(diethoxy)phenyl, acetyloxy(diisopropoxy)phenyl, diacetyloxy(methoxy)phenyl]; mono-, or di(C₁-C₆)alkoxycarbonyloxy and mono-, or di(C₁-C₆)alkoxy substituted phenyl [e.g. methoxycarbonyloxy(methoxy)phenyl, ethoxycarbonyloxy(methoxy)phenyl, ethoxycarbonyloxy(ethoxy)phenyl, methoxycarbonyloxy(dimethoxy)phenyl, ethoxycarbonyloxy(dimethoxy)phenyl, ethoxycarbonyloxy(diethoxy)phenyl, ethoxycarbonyloxy(diisopropoxy)phenyl]; mono-, or di(C₁-C₆)alkyl and mono-, or di[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy] substituted phenyl [e.g. methyl(methoxyethoxymethoxy)phenyl, ethyl(methoxyethoxymethoxy)phenyl, dimethyl(methoxyethoxymethoxy)phenyl, diethyl(methoxyethoxymethoxy)phenyl, diisopropyl(methoxyethoxymethoxy)phenyl, di-tert-butyl(methoxyethoxymethoxy)phenyl]; mono-, or di(C₁-C₆)alkanoyloxy and mono-, or di(C₁-C₆)alkyl substituted phenyl [e.g. acetyloxy(methyl)phenyl, propionyloxy(methyl)phenyl, acetyloxy(ethyl)phenyl, acetyloxy(dimethyl)phenyl, propionyloxy(dimethyl)phenyl, acetyloxy(diethyl)phenyl, acetyloxy(diisopropyl)phenyl, diacetyloxy(methyl)phenyl]; mono-, or di(C₁-C₆)alkoxycarbonyloxy and mono-, or di(C₁-C₆)alkyl substituted phenyl [e.g. methoxycarbonyloxy(methyl)phenyl, ethoxycarbonyloxy(methyl)phenyl, ethoxycarbonyloxy(ethyl)phenyl, methoxycarbonyloxy(dimethyl)phenyl, ethoxycarbonyloxy(dimethyl)phenyl, ethoxycarbonyloxy(diethyl)phenyl, ethoxycarbonyloxy(diisopropyl)phenyl]; mono-, or dihalo and mono-, or di[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy]substituted phenyl [e.g. chloro(methoxyethoxymethoxy)phenyl, dichloro(methoxyethoxymethoxy)phenyl, fluoro(methoxyethoxymethoxy)phenyl]; mono-, or di(C₁-C₆)alkanoyloxy and mono-, or dihalo substituted phenyl [e.g. acetyloxy(chloro)phenyl, propionyloxy(chloro)phenyl, acetyloxy(dichloro)phenyl]; and mono-, or di(C₁-C₆)alkoxycarbonyloxy and mono-, or dihalo substituted phenyl [e.g. methoxycarbonyloxy(chloro)phenyl, ethoxycarbonyloxy(chloro)phenyl, ethoxycarbonyloxy(dichloro)phenyl]. Preferable examples of "phenyl substituted with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and halogen, or with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkoxy" may be the same as above-mentioned mono-, or di-, or tri[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy]phenyl; mono-, or dihalo and mono-, or di[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy]substituted phenyl; mono-, or di(C₁-C₆)alkoxy and mono-, or di[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy] substituted phenyl; and mono-, or di(C₁-C₆)alkyl and mono-, or di[C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy]substituted phenyl. Preferable example of "phenyl substituted with hydroxy, with hydroxy and halogen, with hydroxy and C₁-C₆ alkyl, or with hydroxy and C₁-C₆ alkoxy" may be the same as above-mentioned mono-, or di-, or trihydroxy phenyl; mono-, or dihydroxy and mono-, or dihalo substituted phenyl; mono, or dihydroxy and mono-, or di(C₁-C₆)alkoxy substituted phenyl; and mono-, or dihydroxy and mono-, or di(C₁-C₆)alkyl substituted phenyl. Preferable examples of "phenyl substituted with C₁-C₆ alkoxycarbonyloxy, or with acyloxy selected from C₁-C₆ alkanoyloxy and C₁-C₆ alkoxycarbonyloxy and C₁-C₆ alkoxy" may be the same as above-mentioned mono-, or di-, or tri(C₁-C₆)alkoxycarbonyloxyphenyl; mono-, or di(C₁-C₆)alkanoyloxy and mono-, or di(C₁-C₆)alkoxy substituted phenyl; and mono- or di(C₁-C₆)alkoxycarbonyloxy and mono- or di(C₁-C₆)alkoxy substituted phenyl. Suitable "C₁-C₆ alkylene" may be a straight or branched one such as methylene, ethylene, trimethylene, tetramethylene, ethylethylene, propylene, pentamethylene, hexamethylene. Suitable pharmaceutically acceptable salts of the object compound [I] are conventional non-toxic salts and include a metal salt such as an alkali metal salt [e.g. sodium salt, potassium salt] and an alkaline earth metal salt [e.g. calcium salt, magnesium salt], an acid addition salt such as an organic acid addition salt [e.g. formate, acetate, trifluoroacetate, fumarate, maleate, tartrate, methanesulfonate, benzenesulfonate, toluenesulfonate], an inorganic acid addition salt [e.g. hydrochloride, hydrobromide, sulfate, phosphate], a salt with an amino acid [e.g. aspartic acid salt, glutamic acid salt]. With respect to the salts of the compounds [Ia], [Ib], [Ic] and [Id] in the Processes 2 and 3, it is to be noted that these compounds are included within the scope of the compound [I], and accordingly the suitable examples of the salts of these compounds are to be referred to those as exemplified for the object compound [I]. The processes for preparing the object compounds [I] of the present invention are explained in detail in the following. Process 1 The object compound [I] or its salt can be prepared by reacting a compound [II] or its reactive derivative at the amino group or a salt thereof with a compound [III] or its reactive derivative at the carboxy group or a salt thereof. Suitable reactive derivative at the amino group of the compound [II] may include Schiff's base type imino or its tautomeric enamine type isomer formed by the reaction of the compound [II] with a carbonyl compound such as aldehyde, ketone; a silyl derivative formed by the reaction of the compound [II] with a silyl compound such as bis(trimethylsilyl)acetamide, mono(trimethylsilyl)acetamide, bis(trimethylsilyl)urea; a derivative formed by reaction of the compound [II] with phosphorus trichloride or phosgene. Suitable salts of the compound [II] and its reactive derivative can be referred to the acid addition salt as exemplified for the compound [I]. Suitable reactive derivative at the carboxy group of the compound [III] may include an acid halide, an acid anhydride, an activated amide, an activated ester. Suitable examples of the reactive derivatives may be an acid chloride; an acid azide; a mixed acid anhydride with an acid such as substituted phosphoric acid [e.g. dialkylphosphoric acid, phenylphosphoric acid, diphenylphosphoric acid, dibenzylphosphoric acid, halogenated phosphoric acid], dialkylphosphorous acid, sulfurous acid, thiosulfuric acid, sulfuric acid, sulfonic acid [e.g. methanesulfonic acid], aliphatic carboxylic acid [e.g. acetic acid, propionic acid, butyric acid, isobutyric acid, pivalic acid, pentanoic aid, isopentanoic acid, 2-ethylbutyric acid, trichloroacetic acid] or aromatic carboxylic acid [e.g. benzoic acid]; a symmetrical acid anhydride; an activated amide with imidazole, 4-substituted imidazole, dimethylpyrazole, triazole or tetrazole; or an activated ester [e.g. cyanomethyl ester, methoxymethyl ester, dimethyliminomethyl [(CH₃)₂N ⁺=CH-] ester, vinyl ester, propargyl ester, p-nitrophenyl ester, 2,4-dinitrophenyl ester, trichlorophenyl ester, pentachlorophenyl ester, mesylphenyl ester, phenylazophenyl ester, phenyl thioester, p-nitrophenyl thioester, p-cresyl thioester, carboxymethyl thioester, pyranyl ester, pyridyl ester, piperidyl ester, 8-quinolyl thioester], or an ester with an N-hydroxy compound [e.g. N,N-dimethylhydroxylamine, 1-hydroxy-2-(1H)-pyridone, N-hydroxysuccinimide, N-hydroxyphthalimide, 1-hydroxy-1H-benzotriazole]. These reactive derivatives can optionally be selected from them according to the kind of the compound [III] to be used. Suitable salts of the compound [III] and its reactive derivative may be a base salt such as an alkali metal salt [e.g. sodium salt, potassium salt], an alkaline earth metal salt [e.g. calcium salt, magnesium salt], an ammonium salt, an organic base salt [e.g. trimethylamine salt, triethylamine salt, pyridine salt, picoline salt, dicyclohexylamine salt, N,N′-dibenzylethylenediamine salt]. The reaction is usually carried out in a conventional solvent such as water, alcohol [e.g. methanol, ethanol], acetone, dioxane, acetonitrile, chloroform, methylene chloride, ethylene chloride, tetrahydrofuran, ethyl acetate, N,N-dimethylformamide, pyridine or any other organic solvent which does not adversely influence the reaction. These conventional solvent may also be used in a mixture with water. In this reaction, when the compound [III] is used in a free acid form or its salt form, the reaction is preferably carried out in the presence of a conventional condensing agent such as N,N′-dicyclohexylcarbodiimide; N-cyclohexyl-N′-morpholinoethylcarbodiimide; N-cyclohexyl-N′-(4-diethylaminocyclohexyl)carbodiimide; N,N′-diethylcarbodiimide, N,N′-diisopropylcarbodiimide; N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide; N,N′-carbonylbis-(2-methylimidazole); pentamethyleneketene-N-cyclohexylimine; diphenylketene-N-cyclohexylimine; ethoxyacetylene; 1-alkoxy-1-chloroethylene; trialkyl phosphite; ethyl polyphosphate; isopropyl polyphosphate; phosphorus oxychloride (phosphoryl chloride); phosphorus trichloride; diphenyl phosphorylazide; diphenylphosphinic chloride; thionyl chloride; oxalyl chloride; lower alkyl haloformate [e.g. ethyl chloroformate, isopropyl chloroformate]; triphenylphosphine; 2-ethyl-7-hydroxybenzisoxazolium salt; 2-ethyl-5-(m-sulfophenyl)isoxazolium hydroxide intramolecular salt; 1-(p-chlorobenzenesulfonyloxy)-6-chloro-1H-benzotriazole; so-called Vilsmeier reagent prepared by the reaction of N,N-dimethylformamide with thionyl chloride, phosgene, trichloromethyl chloroforamte, phosphorus oxychloride. The reaction may also be carried out in the presence of an inorganic or organic base such as an alkali metal bicarbonate, tri(lower)alkylamine, pyridine, N-(lower)alkylmorpholine, N,N-di(lower)alkylbenzylamine. The reaction temperature is not critical and the reaction is usually carried out under cooling to warming. Process 2 The compound [Ib] or its salt can be prepared by subjecting a compound [Ia] or its salt to elimination reaction of C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkyl. This reaction is carried out in accordance with a conventional method such as hydrolysis. The hydrolysis is preferably carried out in the presence of a base or an acid including Lewis acid. Suitable base may include an inorganic base and an organic base such as an alkali metal [e.g. sodium, potassium], an alkaline earth metal [e.g. magnesium calcium], the hydroxide or carbonate or bicarbonate thereof, trialkylamine [e.g. trimethylamine, triethylamine], picoline 1,5-diazabicyclo[4.3.0]non-5-ene, 1,4-diazabicyclo[2.2.2]octane, 1,8-diazabicyclo[5.4.0]undec-7-ene. Suitable acid may include an organic acid [e.g. formic acid, acetic acid, propionic acid, trichloroacetic acid, trifluoroacetic acid, methanesulfonic acid, p-toluenesulfonic acid] and an inorganic acid [e.g. hydrochloric acid, hydrobromic acid, sulfuric acid, hydrogen chloride, hydrogen bromide, hydrogen fluoride]. The elimination using trihaloacetic acid [e.g. trichloroacetic acid, trifluoroacetic acid] is preferably carried out in the presence of cation trapping agents [e.g. anisole, phenol]. The reaction is usually carried out in a solvent such as water, an alcohol [e.g. methanol, ethanol], methylene chloride, chloroform, tetrachloromethane, tetrahydrofuran, a mixture thereof or any other solvent which dose not adversely influence the reaction. A liquid base or acid can be also used as the solvent. The reaction temperature is not critical and the reaction is usually carried out under cooling to heating. Process 3 The object compound [Id] or its salt can be prepared by reacting a compound [Ic] or its salt with an acylating agent. Suitable acylating agents are the corresponding carboxylic acid, which are represented by the formula : R²-OH wherein R² is acyl, and reactive derivatives thereof. Suitable "acyl" may be the same as acyl group for "acyloxy" as exemplified above. Suitable said reactive derivatives can be referred to the ones at the carboxy groups of the compound [III] as exemplified above. The kind of such reactive derivatives can be selected depending on the kind of acyl group to be introduced. The reaction is usually carried out in a conventional solvent, such as methylene chloride, chloroform, benzene, toluene, pyridine, diethyl ether, dioxane, tetrahydrofuran, acetone, acetonitrile, ethyl acetate, N,N-dimethylformamide or any other organic solvent which does not adversely affect the reaction. In case that the acylating agent is liquid, it can also be used as a solvent. In case that the carboxylic acid compounds are used as acylating agent in the free acid dorm or salt form, it is preferable to carry out the reaction in the presence of a conventional condensing agent such as N,N′-dicyclohexylcarbodiimide. The reaction temperature is not critical and the reaction can be carried out under cooling, at ambient temperature, or under heating. This reaction is preferably carried out in the presence of an inorganic base, for example an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide, or an alkali metal carbonate or hydrogen carbonate such as sodium carbonate, potassium carbonate, sodium hydrogen carbonate or potassium hydrogen carbonate, or in the presence of an organic base, for example a tertiary amine such as triethylamine, pyridine, N-methylmorpholine or N,N-dimethylaniline. Among the starting compounds [II] and [III], some of them are new and can be prepared by processes as illustrated in the following reaction schemes. Process A Process B wherein R³ is protected amino, R⁴ is protected carboxy, B ′ is methylene, ethylene, trimethylene, vinylene or propenylene, X is a leaving group, R¹ and A are each as defined above. Suitable "protected amino" may be acylamino such as substituted or unsubstituted C₁-C₆ alkanoylamino [e.g. formylamino, acetylamino, propionylamino, trifluoroacetylamino], phthaloylimino, C₁-C₆ alkoxycarbonylamino [e.g. tert-butoxycarbonylamino, tert-amyloxycarbonylamino], substituted or unsubstituted aralkyloxycarbonylamino [e.g. benzyloxycarbonylamino, p-nitrobenzyloxycarbonylamino], substituted or unsubstituted arenesulfonylamino [e.g. benzenesulfonylamino, tosylamino], nitrophenylsulfenylamino, aralkylamino [e.g. tritylamino, benzylamino, etc.]. Suitable "protected carboxy" may be carboxy group protected by conventional protective group such as C₁-C₆ alkoxycarbonyl [e.g. methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, sec-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, pentyloxycarbonyl, neopentyloxycarbonyl, hexyloxycarbonyl], optionally substituted ar(C₁-C₆)alkoxycarbonyl for example, mono or di or triphenyl(C₁-C₆)alkoxycarbonyl which may be substituted with nitro [e.g. benzyloxycarbonyl, 4-nitrobenzyloxycarbonyl, benzhydryloxycarbonyl, trityloxycarbonyl]. Suitable "leaving group" may be an acid residue such as halogen [e.g. chlorine, bromine, fluorine and iodine], sulfonyloxy [e.g. mesyloxy, tosyloxy, phenylsulfonyloxy]. The processes for preparing the starting compounds are explained in detail in the following. Process A Step 1 The compound [VI] or its salt can be prepared by reacting a compound [IV] or its salt with a compound [V] or its salt. Suitable salts of the compounds [IV], [V] and [VI] can be referred to the acid addition salts as exemplified for the compound [I]. This reaction is usually carried out in a conventional solvent such as water, an alcohol [e.g. methanol, ethanol, isopropyl alcohol], dioxane, tetrahydrofuran, N,N-dimethylformamide, methylene chloride, chloroform, tetrachloromethane, or any other conventional solvent which does not adversely affect this reaction, or a mixture thereof. The reaction is carried out at ambient temperature, under warming or under heating, although the reaction temperature is not critical. This reaction can also be conducted in the presence of an inorganic base, for example an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide, or an alkali metal carbonate or hydrogen carbonate such as sodium carbonate, potassium carbonate, sodium hydrogen carbonate or potassium hydrogen carbonate, or in the presence of an organic base, for example a tertiary amine such as triethylamine, pyridine or N,N-dimethylaniline. This reaction can also be performed in the presence of an alkali metal halide such as sodium iodide or potassium iodide. Step 2 The compound [II] or its salt can be prepared by subjecting a compound [VI] or its salt to elimination reaction of the amino-protective group. This elimination reaction can be carried out by a conventional manner, and the reaction mode [e.g. hydrolysis, reduction] and the reaction conditions [e.g. acid, base, catalyst, solvent, reaction temperature] of this reaction can be referred to those of the conventional elimination reaction of the amino-protective group. Process B Step 1 The compound [IX] or its salt can be prepared by reacting a compound [VII] or its salt with a compound [VIII]. Suitable salts of the compounds [VII] and [IX] can be referred to the ones as exemplified for the compound [III]. This reaction is so-called Witting reaction, and the reaction mode and reaction conditions can be referred to those of the conventional Witting reaction. Step 2 The compound [III] or its salt can be prepared by subjecting a compound [VIII] or its salt to elimination reaction of the carboxy-protective group. This elimination reaction can be carried out by a conventional manner, and the reaction mode [e.g. hydrolysis, reduction] and the reaction conditions [e.g. acid, base, catalyst, solvent, reaction temperature] of this reaction can be referred to those of the conventional elimination reaction of the carboxy protective group. The compounds obtained by the above Processes 1, 2, 3, A and B can be isolated and purified by a conventional method such as pulverization, recrystallization, column chromatography, reprecipitation. It is to be noted that each of the object compound [I] and the starting compounds may include one or more stereoisomer due to asymmetric carbon atom(s) and/or carbon-carbon double bond (i.e. Z-isomer and E-isomer), and all such isomers and mixture thereof are included within the scope of this invention. The new indolylpiperidine compound [I] and pharmaceutically acceptable salts thereof possess antiallergic activity and are useful for a therapeutic treatment or prophylaxis of allergic disease such as allergic asthma, allergic rhinitis, allergic conjunctivitis,chronic urticaria. The compound [I] and a pharmaceutically acceptable salt thereof of this invention can be used in the form of conventional solid, semisolid or liquid pharmaceutical preparations in admixture with conventional organic or inorganic carriers or excipients suitable for oral, parenteral or external application. The active ingredients may be admixed with conventional, nontoxic, pharmaceutically acceptable carriers having the form of, for example, tablets, pellets, capsules, patches, suppositories, solutions, emulsions or suspensions or any other form suitable for use. Usable carriers are not limited to any particular species. Thus, conventional carriers such as water, glucose, lactose, gum arabic, gelatin, mannitol, starch paste, magnesium trisilicate, talc, corn starch, keratin, colloidal silica, potato starch and urea and other carriers suitable for the manufacture of solid, semisolid or liquid preparations can be used. Furthermore, auxiliaries, stabilizers, thikening agents and colorants as well as aromas may be added. The dose or therapeutically effective amount of the object compounds [I] of this invention may vary depending on the age and symptoms of each individual patient to be treated. Generally, the active ingredients are administered for disease treatment in a daily dose of about 0.1-100 mg/kg, preferably 0.1-10 mg/kg. In order to illustrate the usefulness of the object compound [I], the pharmacological test data of some representative compounds of the compound [I] are shown in the following. Test Compounds Compound A : 1-[4-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)-piperidine Compound B : 1-[2-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)-piperidine Compound C : 1-[2-{5-(4-Hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine Compound D : 1-[2-{5-(4-Acetoxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)-piperidine Compound E : 1-[2-{5-(4-Acetoxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine Compound F : 1-[2-{5-(3,5-Dichloro-4-hydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine Test 1 Antagonistic action on anaphylactic asthma in guinea pigs Male Hartley-strain guinea pigs weighing 305-400 g were used. These animals were sensitized by intravenous injection of 0.5 ml/animal of rabbit antiserum to egg-white albumin (PCA antibody titer 4,000). After 24 hours, the animals were housed individually in 5.3-liter plastic chambers. Using a commercial sprayer, a 5% egg-white albumin solution was sprayed in the form of an aerosol into each chamber at a rate of 0.16 ml/min for 2 minutes. Thirty minutes prior to the spraying of the egg-white albumin solution, the test compound was administered orally in varied concentrations. Each dosed group consisted of 5 animals. The prophylactic effect to anaphylaxis was expressed in terms of the ED₅₀ value determined on the basis of the number of guinea pigs which has survived for not less than 2 hours after antigen spraying for each administration concentration of the test compound. The values thus obtained are given in the following table. Test 2 Anti-SRS-A activity Peritoneal exudate cells were collected from glycogen-injected SD rats and adjusted to 1 x 10⁷ cells/ml with Tyrode's solution. One milliliter of the cell suspension was incubated with indomethacin (10 µg/ml) and each varied concentration of the test compound for 10 minutes and, then, further incubated with Ca⁺⁺-ionophore (A23187, 1 µg/ml) for 10 minutes. The supernatant was collected by centrifugation and the SRS-A (slow-reacting substance of anaphylaxis) activity was determined in terms of contractility of the isolated guinea pig ileum in the presence of mepyramine, atropine and methysergide. The results were expressed in terms of the 50% inhibitory concentration to SRS-A synthesis or release from periotoneal exudate cells. The following Preparations and Examples are given for the purpose of illustrating the present invention in more detail. Preparation 1 A mixture of 4-(3-indolyl)piperidine (7.88 g), N-(2-bromoethyl)phthalimide (10.0 g) and sodium hydrogen carbonate (3.64 g) in dry N,N-dimethylformamide (93 ml) was heated at 68-74°C for 4 hours. After cooling, the reaction mixture was poured into ice-water (1,000 ml). The resulting precipitate was collected by filtration and washed with methanol to give 1-(2-phthalimidoethyl)-4-(3-indolyl)piperidine (5.53 g). NMR (DMSO-d₆, δ) : 1.3-3.4 (11H, m), 3.77 (2H, t, J=6.0Hz), 6.8-7.8 (5H, m), 7.89 (4H, m), 10.73 (1H, s) MASS : 373 (M⁺), 213 Preparation 2 A mixture of 4-(3-indolyl)piperidine (7.47 g), N-(3-bromopropyl)phthalimide (10.0 g) and sodium hydrogen carbonate (3.45 g) in dry N,N-dimethylformamide (88 ml) was heated at 70°C for 2 hours. After cooling, the reaction mixture was poured into water (880 ml) and extracted with a mixture of chloroform and methanol (10:1, V/V). The organic layer was washed with a saturated sodium chloride solution and dried over magnesium sulfate. The solvent was distilled off and the residue was subjected to column chromatography on silica gel (290 g) and eluted with a mixture of chloroform and methanol (20:1, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was triturated with diethyl ether to give pale yellow crystals of 1-(3-phthalimidopropyl)-4-(3-indolyl)-piperidine (5.83 g). IR (Nujol) : 3360, 1770, 1704, 1040, 735, 712 cm⁻¹ NMR (DMSO-d₆, δ) : 1.0-3.1 (13H, m), 3.67 (2H, t, J=6.0Hz), 6.8-7.6 (5H, m), 7.6-8.0 (4H, m), 10.63 (1H, s) Preparation 3 1-(4-Phthalimidobutyl)-4-(3-indolyl)piperidine was obtained according to a similar manner to that of Preparation 2. IR (Nujol) : 3400-3300 (broad), 1770, 1700 (broad) cm⁻¹ Preparation 4 A mixture of 1-(2-phthalimidoethyl)-4-(3-indolyl)-piperidine (6.3 g) and hydrazine monohydrate (2.2 g) in ethanol (250 ml) was refluxed for 70 minutes. After cooling, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was treated with 5% sodium hydroxide solution (300 ml) and extracted with ethyl acetate (300 ml). The organic layer was washed with a saturated sodium chloride solution and dried over magnesium sulfate. The evaporation of solvent gave 1-(2-aminoethyl)-4-(3-indolyl)piperidine (3.74 g). IR (Nujol) : 3350, 1596, 953, 733 cm⁻¹ NMR (CDCl₃, δ) : 1.5-3.4 (15H, m), 6.8-7.8 (5H, m), 8.5 (1H, br s) MASS : 243 (M⁺), 213 Preparation 5 The following compounds were obtained according to a similar manner to that of Preparation 4. (1) 1-(3-Aminopropyl)-4-(3-indolyl)piperidine IR (Nujol) : 3360, 3150, 1377, 1225 cm⁻¹ NMR (DMSO-d₆, δ) : 1.3-3.2 (17H, m), 6.7-7.7 (5H, m), 10.67 (1H, s) (2) 1-(4-Aminobutyl)-4-(3-indolyl)piperidine IR (Nujol) : 3390, 3150, 1110, 897, 736 cm⁻¹ NMR (DMSO-d₆, δ) : 1.0-3.2 (19H, m), 6.7-7.6 (5H, m), 10.67 (1H, s) Preparation 6 A mixture of 4-hydroxy-3,5-dimethylbenzaldehyde (5 g), N,N-diisopropylethylamine (6.9 ml), (2-methoxyethoxy)methylchloride (4.26 ml) and 1,2-dichloroethane (65 ml) was refluxed for 5 hours. The reaction mixture was washed with water and dried over magnesium sulfate. After removal of the solvent, the residue was subjected to column chromatography on silica gel and eluted with a mixture of n-hexane and ethyl acetate (8:2, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure to give 4-[(2-methoxyethoxy)methoxy]-3,5-dimethylbenzaldehyde (6.54 g). IR (Neat) : 2900, 1690, 1600, 1130, 1100, 960, 740 cm⁻¹ NMR (CDCl₃, δ) : 2.30 (6H, s), 3.32 (3H, s), 3.75, 4.0 (each 2H, m), 5.19 (2H, m), 7.60 (2H, s), 9.93 (1H, s) Preparation 7 The following compounds were obtained according to a similar manner to that of Preparation 6. (1) 3,5-Diisopropyl-4-[(2-methoxyethoxy)methoxy]-benzaldehyde IR (Nujol) : 2950, 1690, 1595, 1585, 955 cm⁻¹ (2) 4-[(2-Methoxyethoxy)methoxy]-3-methylbenzaldehyde IR (Neat) : 2950, 1690, 1600, 1590, 980 cm⁻¹ NMR (CDCl₃, δ) : 2.31 (3H, s), 3.38 (3H, s), 3.6, 3.8 (each 2H, m), 5.41 (2H, s), 7.15-7.85 (3H, m), 9.90 (1H, s) (3) 3-Chloro-4-[(2-methoxyethoxy)methoxy]benzaldehyde IR (Neat) : 1700, 1595, 1570, 950 cm⁻¹ NMR (CDCl₃, δ) : 3.30 (3H, m), 3.6, 3.8 (each, 2H, m), 5.53 (2H, s), 7.2-7.9 (3H, m), 9.88 (1H, s) (4) 3,5-Dichloro-4-[(2-methoxyethoxy)methoxy]benzaldehyde IR (Neat) : 2900, 1705, 1590, 1560, 920, 810 cm⁻¹ NMR (CDCl₃, δ) : 3.4 (3H, s), 3.6, 4.1 (each 2H, m), 5.38 (2H, s), 7.82 (2H, s), 9.85 (1H, s) (5) 3-Methoxy-2-[(2-methoxyethoxy)methoxy]benzaldehyde IR (Neat) : 1690, 1585, 950, 850, 785, 750 cm⁻¹ NMR (CDCl₃, δ) : 3.40 (3H, s), 3.6, 3.9 (each 2H, m), 3-95 (3H, s), 5.38 (2H, s), 7.2-7.6 (3H, m), 10.53 (1H, s) MASS (m/e) : 240 (M⁺), 89, 59 (6) 3,5-Di-tert-butyl-4-[(2-methoxyethoxy)methoxy]benzaldehyde IR (Neat) : 1695, 1595, 945 cm⁻¹ Preparation 8 To a stirred suspension of 60% sodium hydride (1.01 g) in dry tetrahydrofuran (60 ml), 80% triethyl 4-phosphonocrotonate (6.57 g) was added dropwise below 10°C under an inert atmosphere. After being stirred for 30 minutes, a solution of 4-[(2-methoxyethoxy)methoxy]-3,5-dimethylbenzaldehyde (5.0 g) in dry tetrahydrofuran (50 ml) was added thereto below 10°C. After stirring for 2 hours, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (100 ml), washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate. The solvent was distilled off and the residue was subjected to column chromatography on silica gel (130 g) and eluted with a mixture of n-hexane and ethyl acetate (7:3, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure to give a syrup of ethyl 5-[4-{(2-methoxyethoxy)methoxy}-3,5-dimethylphenyl]-(2E,4E)-2,4-pentadienoate (5.28 g). IR (Neat) : 2950, 1710, 1620, 1600, 970, 865 cm⁻¹ Preparation 9 The following compounds were obtained according to a similar manner to that of Preparation 8. (1) Ethyl 5-[3,5-diisopropyl-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoate IR (Nujol) : 1710, 1625, 1595, 965, 870 cm⁻¹ NMR (CDCl₃, δ) : 1.25 (12H, d, J=8Hz), 1.31 (3H, t, J=8Hz), 3.45 (2H, sextet, J=8Hz), 3.43 (3H, s), 3.7, 4-0 (each 2H, m), 4.25 (2H, q, J=8Hz), 5.03 (2H, s), 6.0 (1H, d, J=15Hz), 6.8-7.7 (5H, m) MASS (m/e) : 362 (M⁺), 89, 59 (base) (2) Ethyl 5-[4-{(2-methoxyethoxy)methoxy}-3-methylphenyl]-(2E,4E)-2,4-pentadienoate NMR (CDCl₃, δ) : 1.31 (3H, t, J=8Hz), 2.25 (3H, s), 3.35 (3H, s), 3.7, 3.9 (each, 2H, m), 4.25 (2H, q, J=8Hz), 5.31 (2H, s), 5.95 (1H, d, J=15Hz), 6.7-7.7 (6H, m) MASS (m/e) : 320 (M⁺), 276, 89, 59 (3) Ethyl 5-[3-chloro-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoate IR (Neat) : 2900, 1710, 1630, 1600, 1055, 980 cm⁻¹ NMR (CDCl₃, δ) : 1.31 (3H, t, J=8Hz), 3.35 (3H, s), 3.7, 3.9 (each 2H, m), 4.28 (2H, q, J=8Hz), 5.33 (2H, s), 5.97 (1H, d, J=15Hz), 6.7-7.7 (6H, m) (4) Ethyl 5-[3,5-dichloro-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoate mp : 67-69°C (recrystallized from a mixture of toluene and ethyl acetate (8:1)) IR (Nujol) : 1710, 1630, 1545, 1000, 925, 860, 800 cm⁻¹ NMR (CDCl₃, δ) : 1.30 (3H, t, J=8Hz), 3.38 (3H, s), 3.6, 4.1 (each 2H, m), 4.23 (2H, q, J=8Hz), 5.29 (2H, s), 6.03 (1H, d, J=15Hz), 6.6-7.7 (5H, m) MASS (m/e) : 376 (M+2), 375 (M+1), 374 (M⁺), 89 (base) (5) Ethyl 5-[3-methoxy-2-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoate mp : 48-49°C (recrystallized from a mixture of n-hexane and diisopropyl ether) IR (Nujol) : 1720, 1623, 1000, 945, 850 cm⁻¹ NMR (CDCl₃, δ) : 1.35 (3H, t, J=7Hz), 3.4 (3H, s), 3.6, 3.9 (each 2H, m), 3.86 (3H, s), 4.27 (2H, q, J=7Hz), 5.25 (2H, s), 6.03 (1H, d, J=15Hz), 6.6-7.7 (6H, m) (6) Ethyl 5-[4-methoxy-3-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoate IR (Neat) : 1710, 1625, 1600, 1000 cm⁻¹ NMR (CDCl₃, δ) : 1.36 (3H, t, J=7Hz), 3.4 (3H, s), 3.6, 3.9 (each 2H, m), 3.90 (3H, s), 4.25 (2H, q, J=7Hz), 5.31 (2H, s), 5.98 (1H, d, J=15Hz), 6.6-7.8 (6H, m) (7) Ethyl 5-[3,5-di-tert-butyl-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoate IR (Neat) : 1710, 1625 cm⁻¹ Preparation 10 To a stirred solution of ethyl 5-[4-{(2-methoxyethoxy)methoxy}-3,5-dimethylphenyl}-(2E,4E)-2,4-pentadienoate (5.28 g) in methanol (55 ml) was added a solution of sodium hydroxide (6.32 g) in water (18 ml) below 20°C. After being stirred for an hour, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in water (200 ml) and adjusted to pH 4 with 10% hydrochloride solution. The resulting precipitate was collected by filtration and washed with water to give yellowish powder of 5-[4-{(2-methoxyethoxy)-methoxy}-3,5-dimethylphenyl]-(2E,4E)-2,4-pentadienoic acid (4.13 g). mp : 88-91°C IR (Nujol): 2650, 1675, 1615, 1595, 1000 970, 860 cm⁻¹ NMR (CDCl₃, δ) : 2.30 (6H, s), 3.43 (3H, s), 3.7, 4.0 (each 2H, m), 5.05 (2H, s), 5.95 (1H, d, J=15Hz), 6.75-7.8 (5H, m), 10.25 (1H, m) MASS (m/e) : 306 (M⁺), 89 (base) Preparation 11 The following compounds were obtained according to a similar manner to that of Preparation 10. (1) 5-[3,5-Diisopropyl-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoic acid mp : 96-113°C IR (Nujol) : 2600, 1685, 1615, 1595, 1100, 1080, 970 cm⁻¹ NMR (CDCl₃, δ) : 1.25 (12H, d, J=8Hz), 3.45 (2H, sextet, J=8Hz), 3.43 (3H, s), 3.7, 4.0 (each 2H, m), 5.03 (2H, s), 6.0 (1H, d, J=15Hz), 6.8-7.8 (5H, m), 10.13 (1H, m) MASS (m/e) : 362 (M⁺), 89, 59 (base) (2) 5-[4-{(2-Methoxyethoxy)methoxy}-3-methylphenyl]-(2E,4E)-2,4-pentadienoic acid mp : 117-119°C IR (Nujol) : 2600, 1670, 1600, 1000, 930 cm⁻¹ NMR (CDCl₃, δ) : 2.26 (3H, s), 3.30 (3H, s), 3.6, 3.9 (each, 2H, m), 5.32 (2H, s), 5.98 (1H, d, J=15Hz), 6.7-7.8 (6H, m), 8.7 (1H, m) (3) 5-[3-Chloro-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoic acid mp : 130-135°C IR (Nujol) : 2600, 1680, 1615, 1590, 1050, 995 cm⁻¹ NMR (CDCl₃, δ) : 3.30 (3H, s), 3.6, 3.9 (each 2H, m), 5.38 (2H, s), 6.01 (1H, d, J=15Hz), 6.7-7.7 (6H, m), 9.7 (1H, m) (4) 5-[3,5-Dichloro-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoic acid mp : 116-120°C IR (Nujol) : 2600, 1690, 1630, 990, 905, 805 cm⁻¹ NMR (CDCl₃, δ) : 3.40 (3H, s), 3.6, 4.1 (each 2H, m), 5.29 (2H, s), 6.05 (1H, d, J=15Hz), 6.7-7.7 (5H, m), 9.65 (1H, br) MASS (m/e) : 348 (M+2), 346 (M⁺), 89, 59 (base) (5) 5-[3-Methoxy-2-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoic acid mp : 140-144°C IR (Nujol) : 2600, 1690, 1610, 1050, 955 cm⁻¹ NMR (CDCl₃, δ) : 3.33 (3H, s), 3.5, 3.8 (each 2H, m), 3.80 (3H, s), 5.15 (2H, s), 5.93 (1H, d, J=15Hz), 6.7-7.7 (6H, m), 9.5 (1H, br) (6) 5-[4-Methoxy-3-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoic acid mp : 121-125°C IR (Nujol) : 2600, 1670, 1620, 1590 cm⁻¹ NMR (CDCl₃, δ) : 3.35 (3H, s), 3.55, 3.90 (each 2H, m), 3-86 (3H, s), 5.30 (2H, s), 5.92 (1H, d, J=15Hz), 6.7-7.7 (6H, m), 10.2 (1H, br) (7) 5-[3,5-Di-tert-butyl-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoic acid IR (Nujol) : 2650, 1680, 1620, 970 cm⁻¹ NMR (CDCl₃, δ) : 1.46 (18H, s), 3.42 (3H, s), 3.66, 3.96 (each 2H, m), 5.0 (2H, s), 5.97 (1H, d, J=15.5Hz), 6.6-7.7 (5H, m), 9.2 (1H, br) Example 1 To a stirred mixture of 3-[3-methoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(E)-propenoic acid (1.75 g) and triethylamine (1.81 ml) in dry N,N-dimethylformamide (10 ml) was added slowly diphenyl phosphinic chloride (1.47 g) at -10 to -15°C under an inert atmosphere. After being stirred for 30 minutes, a solution of 1-(2-aminoethyl)-4-(3-indolyl)piperidine (1.5 g) in dry N,N-dimethylformamide (10 ml) was added slowly to the reaction mixture at -10°C. After being stirred for 1 hour at ambient temperature, the reaction mixture was poured into ice-water (200 ml) and extracted with chloroform (100 ml). The extract was washed with a saturated sodium chloride solution and dried over magnesium sulfate. The solvent was distilled off and the residue was subjected to column chromatography on silica gel (47 g) and eluted with a mixture of chloroform and methanol (10:1). The fractions containing the object compound were combined and concentrated under reduced pressure to give syrup of 1-[2-[3-[3-methoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(E)-propenoylamino]ethyl]-4-(3-indolyl)piperidine (2.8 g). NMR (CDCl₃, δ) : 1.6-3.3 (11H, m), 3.37 (3H, s), 3.55 (4H, m), 3.85 (2H, m), 3.89 (3H, s), 5.32 (2H, s), 6.35 (1H, d, J=15.0Hz), 6.52 (1H, br s), 6.9-7.8 (8H, m), 7.57 (1H, d, J=15.0Hz), 8.25 (1H, br s) Example 2 The following compounds were obtained according to a similar manner to that of Example 1. (1) 1-[2-[5-[3-Methoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3300, 1660, 1260, 1092, 990, 744 cm⁻¹ NMR (CDCl₃, δ) : 1.6-3.3 (11H, m), 3.35 (3H, s), 3.54 (4H, m), 3.84 (2H, m), 3.86 (3H, s), 5.30 (2H, s), 6.07 (1H, d, 15.0Hz), 6.70-7.80 (12H, m), 9.30 (1H, s) MASS : 533 (M⁺), 213 (2) 1-[3-[5-[3-Methoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]propyl]-4-(3-indolyl)piperidine NMR (CDCl₃, δ) : 1.5-3.6 (15H, m), 3.36 (3H, s), 3.6 (2H, m), 3.87 (3H, s), 3.90 (2H, m), 5.35 (2H, s), 6.02 (1H, d, J=14.4Hz), 6.6-7.9 (12H, m), 8.55 (1H, s) MASS : 547 (M⁺) (3) 1-[4-[5-[3-Methoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]butyl]-4-(3-indolyl)piperidine IR (Nujol) : 3400, 3200 (broad), 1650, 1377, 1260 cm⁻¹ NMR (CDCl₃, δ) : 1.3-3.4 (17H, m), 3.33 (3H, s), 3.55 (2H, m), 3.80 (5H, br s), 5.27 (2H, s), 6.11 (1H, d, J=15.0Hz), 6.5-8.0 (12H, m), 9.23 (1H, s) MASS : 561 (M⁺) (4) 1-[2-{5-(3,4-Dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine mp : 196-198°C (recrystallized from ethanol) IR (Nujol) : 3280, 1640, 1610, 1590, 1550, 1510 cm⁻¹ NMR (DMSO-d₆, δ) : 1.4-3.5 (13H, m), 3.78 (3H, s), 3.81 (3H, s), 6.15 (1H, d, J=15.0Hz), 6.8-7.6 (11H, m), 7.99 (1H, br t), 10.75 (1H, br s) MASS : 459 (M⁺), 213 Elemental Analysis : C₂₈H₃₃N₃O₃ Calcd. : C 73.18, H 7.24, N 9.14 Found : C 73.84, H 7.42, N 8.72 (5) 1-[2-{5-(3,4,5-Trimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine mp : 86-100°C IR (Nujol) : 3250, 1650, 1610, 1580 cm⁻¹ NMR (DMSO-d₆, δ) : 1.4-3.6 (13H, m), 3.70 (3H, s), 3.83 (6H, s), 6.19 (1H, d, J=15.0Hz), 6.7-7.7 (10H, m), 8.02 (1H, br t), 10.74 (1H, br s) MASS : 489 (M⁺) 289, 213 Elemental Analysis : C₂₉H₃₅N₃O₄·3/4H₂O Calcd. : C 69.23, H 7.31, N 8.35 Found : C 69.38, H 7.08, N 8.40 (6) 1-[2-{3-(4-Hydroxy-3-methoxyphenyl)-(E)-propenoyl-amino}ethyl]-4-(3-indolyl)piperidine mp : 115-135°C IR (Nujol) : 3300 (broad), 1655, 1588, 1512 cm⁻¹ (7) 1-[2-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine mp : 115-131°C IR (Nujol) : 3330 (broad), 1660, 1377 cm⁻¹ (8) 1-[3-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}propyl]-4-(3-indolyl)piperidine mp : 150-170°C IR (Nujol) : 3400, 3200 (broad), 1638, 1580 cm⁻¹ (9) 1-[4-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)piperidine mp : 150-170°C IR (Nujol) : 3200 (broad), 1640, 1580, 1270, 735 cm⁻¹ (10) 1-[2-[5-[3,4-Bis{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)-piperidine This compounds was used as a starting compound of Example 7-(4) without purification. (11) 1-[2-[5-[3,5-Dimethoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3300, 1650, 1610, 1580, 1125, 990, 960, 845, 745 cm⁻¹ (12) 1-[3-[5-[3,5-Dimethoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]propyl]-4-(3-indolyl)piperidine IR (Neat) : 3300, 3000, 2990, 1650, 1615, 1580, 1130, 990, 960, 850 cm⁻¹ (13) 1-[4-[5-[3,5-Dimethoxy-4-{(2-methoxyethoxy)methoxy}phenyl-(2E,4E)-2,4-pentadienoylamino]butyl]-4-(3-indolyl)piperidine IR (Neat) : 2900, 1650, 1610, 1580, 1550, 1120, 960, 850, 740 cm⁻¹ (14) 1-[2-[5-[4-{(2-Methoxyethoxy)methoxy}-3,5-dimethylphenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine mp : 163-164°C (recrystallized from ethyl acetate) IR (Nujol) : 3450, 3300, 1645, 1615, 990, 970 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-2.3 (6H, m), 2.34 (6H, s), 2.5-3.1 (7H, m), 3.25 (3H, s), 3.5, 3.8 (each 2H, m), 5.05 (2H, s), 6.15 (1H, d, J=15Hz), 6.8-7.7 (10H, m), 8.03 (1H, m), 10.7 (1H, m) MASS (m/e) : 531 (M⁺), 213 (base) (15) 1-[2-[5-[3,5-Diisopropyl-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine IR (Neat) : 1660, 1650, 1615, 970 cm⁻¹ (16) 1-[2-[5-[4-{(2-Methoxyethoxy)methoxy}-3-methylphenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine mp : 140-144°C IR (Nujol) : 3470, 3280, 1640, 1610, 1595, 1000, 980 cm⁻¹ NMR (CDCl₃, δ) : 1.6-3.2 (13H, m), 2.25 (3H, s), 3.38 (3H, s), 3.6, 3.8 (each, 2H, m), 5.32 (2H, s), 5.96 (1H, d, J=15Hz), 6.2-7.8 (11H, m), 8.25 (1H, m) MASS (m/e) : 517 (M⁺), 213 (base) (17) 1-[2-[5-[3-Chloro-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3450, 3300, 1645, 1610, 1050, 990 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-2.5 (6H, m), 2.8-3.2 (7H, m), 3.65 (3H, s), 3.6, 3.8 (each 2H, m), 5.39 (2H, s), 6.10 (1H, d, J=15Hz), 6.8-7.9 (11H, m), 8.05 (1H, m), 10.75 (1H, m) MASS (m/e) : 537, 213 (base) (18) 1-[2-{5-(3,4-Dihydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3400, 3350, 1650, 1585, 1520 cm⁻¹ MASS (m/e) : 431 (M⁺), 213 (base) (19) 1-[2-{5-(4-Hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3420, 1665, 1650, 1620, 1590, 1530, 1515, 1120 cm⁻¹ MASS (m/e) : 475 (M⁺), 213 (20) 1-[4-{5-(4-Hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)piperidine IR (Nujol) : 3250, 1640, 1600, 1540, 1510, 1130, 1110, 810 cm⁻¹ (21) 1-[3-{5-(4-Hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}propyl]-4-(3-indolyl)piperidine IR (Nujol) : 3420, 1658, 1610, 1575, 1550, 1510, 1120 cm⁻¹ MASS (m/e) : 489 (M⁺), 239, 233, 213 (base), 197 (22) 1-[2-{5-(4-Acetoxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl}-4-(3-indolyl)piperidine IR (Nujol) : 3440, 3250, 1760, 1655, 1620, 1560, 1505 cm⁻¹ MASS (m/e) : 487 (M⁺), 213 (base) (23) 1-[2-{5-(3-Methoxy-4-propionyloxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3430, 3250, 3060, 1750, 1655, 1620, 1560 cm⁻¹ MASS (m/e) : 501 (M⁺), 213 (base) (24) 1-[2-{5-(4-Ethoxycarbonyloxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3360, 3300, 1750, 1640, 1590, 1130, 1000, 735 cm⁻¹ MASS (m/e) : 547 (M⁺), 228, 213 (base) (25) 1-[4-{5-(4-Ethoxycarbonyloxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)piperidine IR (Nujol) : 3380, 3250, 1750, 1655, 1620, 1595, 1555, 1130, 1050, 1000, 735 cm⁻¹ MASS (m/e) : 575 (M⁺), 531, 503, 285, 233, 213 (base) (26) 1-[2-{5-(4-Hydroxy-3,5-dimethylphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3300, 1640, 1590, 1545, 990, 860 cm⁻¹ MASS (m/e) : 443 (M⁺), 213 (base) (27) 1-[2-{5-(4-Hydroxy-3,5-diisopropylphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3400, 3300, 1650, 1630, 1585, 995, 870 cm⁻¹ MASS (m/e) : 499 (M⁺), 226, 213 (base) (28) 1-[2-{5-(4-Hydroxy-3-methylphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3200, 1640, 1575, 1550, 1000 cm⁻¹ MASS (m/e) : 429 (M⁺), 213 (base) (29) 1-[2-{5-(3-Chloro-4-hydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3420, 1650, 1590, 1000 cm⁻¹ MASS (m/e) : 449 (M⁺), 213 (base) (30) 1-[2-{5-(4-Acetoxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3380, 3320, 1755, 1650, 1620, 1595, 990, 745 cm⁻¹ MASS (m/e) : 517 (M⁺), 213 (base) (31) 1-[2-[5-[3,5-Dichloro-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine IR (Neat) : 1655, 1610, 995 cm⁻¹ (32) 1-[2-[5-[3-Methoxy-2-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine IR (Neat) : 1650, 1610, 1000, 960 cm⁻¹ (33) 1-[2-[5-[4-Methoxy-3-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine mp : 135-136°C (recrystallized from ethyl acetate) IR (Nujol) : 3260, 1640, 1615, 1595, 1550, 1510 cm⁻¹ NMR (DMSO-d₆, δ) : 3.75 (3H, s), 5.23 (2H, s), 6.11 (1H, d, J=15Hz), 6.7-7.6 (11H, m), 7.96 (1H, t like), 10.7 (1H, br) MASS (m/e) : 533, 445, 333, 213 (base) (34) 1-[2-[5-[3,5-Di-tert-butyl-4-{(2-methoxyethoxy)-methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]-ethyl]-4-(3-indolyl)piperidine mp : 98-103°C (recrystallized from ethanol) IR (Nujol) : 3300, 1650, 1600, 970 cm⁻¹ NMR (CDCl₃, δ) : 1.42 (18H, s), 1.6-2.3 (6H, m), 2.53 (2H, t, J=7Hz), 2.8 (3H, m), 3.35 (3H, s), 3.5 (2H, m), 3.66, 3.96 (each 2H, m), 4.93 (2H, s), 5.95 (1H, d, J=15.5Hz), 6.17 (1H, t like), 6.6-7.7 (10H, m), 8.2 (1H, s) (35) 1-[2-{5-(3,5-Di-tert-butyl-4-hydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3550, 3300, 3230, 1650, 1610, 1590, 1000 cm⁻¹ MASS (m/e) : 527 (M⁺), 226, 213 (36) 1-[2-{5-(3,5-Dichloro-4-hydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine MASS (m/e) : 485 (M+2), 483 (M⁺), 213 (base) (37) 1-[2-{5-(2-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3400, 3240, 1650, 1605, 1600, 1530, 1090, 1005 cm⁻¹ MASS (m/e) : 445 (M⁺), 226, 213 (base) (38) 1-[2-{5-(3-Hydroxy-4-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3350, 1650, 1615, 1590 cm⁻¹ MASS (m/e) : 445 (M⁺), 213 (base) (39) 1-[2-[5-{3,4-bis(Ethoxycarbonyloxy)phenyl}-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine IR (Nujol) : 3500, 3350, 1775, 1650, 1620, 1000 cm⁻¹ MASS (m/e) : 529 (M⁺-46), 457, 285 (base), 213 Example 3 To a solution of 1-[2-[5-[3,5-di-tert-butyl-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine (0.5 g) in methanol (5 ml) was added dropwise methanesulfonic acid (0.26 ml) at 18-25°C. After 2 hours the reaction mixture was adjusted to pH 7.5 with 2N-sodium hydroxide and then poured into saturated sodium bicarbonate solution (50 ml). The resulting precipitate was collected and washed with water. The precipitate was subjected to column chromatography on silica gel and eluted with a mixture of chloroform and methanol (20:1, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was recrystallized from 1,4-dioxane, to give white crystals of 1-[2-{5-(3,5-di-tert-butyl-4-hydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine (0.28 g). See Example 2-(35). mp : 108-115°C IR (Nujol) : 3550, 3300, 3230, 1650, 1610, 1590, 1000 cm⁻¹ NMR (CDCl₃, δ) : 1.43 (18H, s), 1.6-2.3 (6H, m), 2.53 (2H, t, J=7Hz), 2.7-3.2 (3H, m), 3.45 (2H, m), 5.33 (1H, s), 5.93 (1H, d, J=15.5Hz), 6.15 (1H, t like), 6.65-7.7 (10H, m), 8.16 (1H, s) MASS (m/e) : 527 (M⁺), 226, 213 Example 4 To a stirred solution of 1-[2-[5-[3,5-dimethoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine (10.0 g) in methanol (100 ml) was added slowly methanesulfonic acid (2.3 ml) at ambient temperature. After stirring for 2 hours, the reaction mixture was adjusted to pH 7.2 with aqueous 2N sodium hydroxide solution, and poured into a solution of 4.5 g of sodium bicarbonate in 500 ml of water. After stirring for 30 minutes, the resulting precipitate was collected by filtration and washed with 100 ml of water. The residue was subjected to column chromatography on silica gel and eluted with a mixture of chloroform and methanol. The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was recrystallized from ethanol to give 1-[2-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl) piperidine (6.69 g). See Example 2-(19). mp : 199-202°C (dec.) IR (Nujol) : 3420, 1665, 1650, 1620, 1590, 1530, 1515, 1120 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-2.4 (7H, m), 2.7-3.5 (6H, m), 3.81 (6H, s), 6.15 (1H, d, J=14Hz), 6.8-7.8 (10H, m), 8.0 (1H, t like), 8.68 (1H, m), 10.75 (1H, s) MASS (m/e) : 475 (M⁺), 213 Elemental Analysis : C₂₈H₃₃N₃O₄ Calcd. : C 70.71, H 6.99, N 8.83 Found : C 70.34, H 6.56, N 8.65 Example 5 A mixture of 1-[3-[5-[3,5-dimethoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]propyl]-4-(3-indolyl)piperidine (1.67 g) and p-toluene-sulfonic acid monohydrate (0.64 g) in methanol (33 ml) was refluxed for 30 minutes under an inert atmosphere. Upon cooling to ambient temperature, the mixture was added dropwise to an aqueous sodium carbonate solution. The resulting powder was subjected to column chromatography on silica gel and eluted with a mixture of chloroform and methanol (10:1, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure. The obtained residue was recrystallized from a mixture of ethanol and water (7:3, V/V) to give 1-[3-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}propyl]-4-(3-indolyl)piperidine (0.51 g). See Example 2-(21). mp : 176-179°C (recrystallized from ethanol-water (8:2, V/V)) IR (Nujol) : 3420, 1658, 1610, 1575, 1550, 1510, 1120 cm⁻¹ NMR (DMSO-d₆, δ) : 1.4-2.5 (9H, m), 2.6-3.5 (6H, m), 3.79 (6H, s), 6.10 (1H, d, J=15Hz), 6.7-7.7 (10H, m), 8.05 (1H, t like), 8.7 (1H, m), 10.72 (1H, s) MASS (m/e) : 489 (M⁺), 239, 233, 213 (base), 197 Elemental Analysis : C₂₉H₃₅N₃O₄ Calcd. : C 71.14, H 7.20, N 8.58 Found : C 70.79, H 7.12, N 8.57 Example 6 A mixture of 1-[2-[3-[3-methoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(E)-propenoylamino]ethyl]-4-(3-indolyl)piperidine (2 g) and p-toluenesulfonic acid monohydrate (1.05 g) in methanol (40 ml) was refluxed for 30 minutes under an inert atmosphere. After the solvent was removed under reduced pressure, the residue was treated with water (100 ml), adjusted to pH 10.0 with a sodium carbonate solution and extracted with ethyl acetate. The extract was washed with a saturated sodium chloride solution and dried over magnesium sulfate. After removal of the solvent, the residue was subjected to column chromatography on silica gel (31 g) and eluted with a mixture of chloroform and methanol (8:1, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure to give 1-[2-{3-(4-hydroxy-3-methoxyphenyl)-(E)-propenoylamino}ethyl]-4-(3-indolyl)piperidine (0.89 g). See Example 2-(6). mp : 115-135°C IR (Nujol) : 3300 (broad), 1655, 1588, 1512 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-3.6 (14H, m), 3.83 (3H, s), 6.50 (1H, d, J=15.0Hz), 6.7-7.7 (9H, m), 7.83 (1H, br t), 10.70 (1H, s) MASS : 419 (M⁺), 213 Elemental Analysis : C₂₅H₂₉N₃O₃·1/2H₂O Calcd. : C 70.00, H 7.06, N 9.80 Found : C 70.18, H 6.92, N 9.85 Example 7 The following compounds were obtained according to similar manners to those of Examples 3 to 6. (1) 1-[2-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(7). mp : 115-131°C IR (Nujol) : 3330 (broad), 1660, 1377 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-3.6 (13H, m), 3.82 (3H, s), 6.07 (1H, d, J=15.0Hz), 6.6-7.6 (8H, m), 7.90 (1H, br t), 9.20 (1H, s), 10.68 (1H, s) MASS : 445 (M⁺), 213 Elemental Analysis : C₂₇H₃₁N₃O₃·1/2H₂O Calcd. : C 71.34, H 7.10, N 9.24 Found : C 71.15, H 6.87, N 9.19 (2) 1-[3-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}propyl]-4-(3-indolyl)piperidine See Example 2-(8). mp : 150-170°C IR (Nujol) : 3400, 3200 (broad), 1638, 1580 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-3.8 (15H, m), 3.86 (3H, s), 4.20 (1H, broad), 6.15 (1H, d, J=14.0Hz), 6.6-7.8 (11H, m), 8.26 (1H, br s), 10.82 (1H, s) MASS : 459 (M⁺), 213 Elemental Analysis : C₂₈H₃₃N₃O₃·1/2CHCl₃·1/2C₂H₅OC₂H₅ Calcd. : C 65.85, H 6.97, N 7.55 Found : C 65.67, H 7.18, N 7.87 (3) 1-[4-{5-(4-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)piperidine See Example 2-(9). mp : 150-170°C IR (Nujol) : 3200 (broad), 1640, 1580, 1270, 735 cm⁻¹ NMR (DMSO-d₆, δ) : 1.2-3.7 (17H, m), 3.80 (3H, s), 6.07 (1H, d, J=15.0Hz), 6.6-7.8 (11H, m), 8.10 (1H, s), 9.25 (1H, s), 10.82 (1H, s) MASS : 473 (M⁺), 213 Elemental Analysis : C₂₉H₃₅N₃O₃·1/2CHCl₃·1/2C₂H₅OC₂H₅ Calcd. : C 66.33, H 7.16, N 7.37 Found : C 66.02, H 7.47, N 7.33 (4) 1-[2-{5-(3,4-Dihydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(18). mp : 138-158°C (dec.) (recrystallized from ethanol-water (8:2, V/V)) IR (Nujol) : 3400, 3350, 1650, 1585, 1520 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-3.6 (13H, m), 6.13 (1H, d, J=15Hz), 6.63-7.70 (11H, m), 7.93 (1H, m), 10.73 (1H, br) MASS (m/e) : 431 (M⁺), 213 (base) Elemental Analysis : C₂₆H₂₉N₃O₃·6/5 ethanol Calcd. : C 70.07, H 7.49, N 8.63 Found : C 69.77, H 7.39, N 8.67 (5) 1-[4-{5-(4-Hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)piperidine See Example 2-(20). IR (Nujol) : 3250, 1640, 1600, 1540, 1510, 1130, 1110, 810 cm⁻¹ (6) 1-[2-{5-(4-Hydroxy-3,5-dimethylphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(26). mp : 125-135°C (recrystallized from ethanol-water (8:2, V/V)) IR (Nujol) : 3300, 1640, 1590, 1545, 990, 860 cm⁻¹ NMR (DMSO-d₆, δ) : 1.4-2.4 (6H, m), 2.19 (6H, s), 2.6-3.2 (7H, m), 6.11 (1H, d, J=15Hz), 6.7-7.6 (10H, m), 7.95 (1H, m), 10.82 (1H, m) MASS (m/e) : 443 (M⁺), 213 (base) Elemental Analysis : C₂₈H₃₃N₃O₂·4/3H₂O Calcd. : C 71.92, H 7.69, N 8.99 Found : C 72.00, H 7.69, N 8.88 (7) 1-[2-{5-(4-Hydroxy-3,5-diisopropylphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(27). mp : 110-120°C (recrystallized from ethanol-water (8:2, V/V)) IR (Nujol) : 3400, 3300, 1650, 1630, 1585, 995 870 cm⁻¹ NMR (DMSO-d₆, δ) : 1.28 (12H, d, J=8Hz), 1.5-2.4 (6H, m), 2.7-3.6 (9H, m), 6.13 (1H, d, J=15Hz), 6.8-7.6 (10H, m), 7.95 (1H, m), 8.4 (1H, m), 10.73 (1H, m) MASS (m/e) : 499 (M⁺), 226, 213 (base) Elemental Analysis : C₃₂H₄₁N₃O₂·H₂O Calcd. : C 74.24, H 8.37, N 8.11 Found : C 73.84, H 8.42, N 7.97 (8) 1-[2-{5-(4-Hydroxy-3-methylphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(28). mp :: 138-141°C (recrystallized from a mixture of ethanol-water (8:2, V/V)) I.R (Nujol) : 3200, 1640, 1575, 1550, 1000 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-3.6 (13H, m), 2.20 (3H, s), 6.10 (1H, d, J=15Hz), 6.7-7.7 (11H, m), 7.93 (1H, m), 9.65 (1H, m), 10.73 (1H, m) MASS (m/e) : 429 (M⁺), 213 (base) Elemental Analysis : C₂₇7H₃₁N₃O₂·5/4H₂O Calcd. : C 71.73, H 7.47, N 9.29 Found : C 71.78, H 7.73, N 9.28 (9) 1-[2-{5-(3-Chloro-4-hydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(29). mp : 139-155°C (recrystallized from ethanol-water) IR (Nujol) : 3420, 1650, 1590, 1000 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-3.5 (13H, m), 6.12 (1H, d, J=15Hz), 6.7-7.7 (11H, m), 7.98 (1H, m), 10.7 (1H, m) MASS (m/e) : 449 (M⁺), 213 (base) Elemental Analysis : C₂₆H₂₈ClN₃O₂·1.5H₂O Calcd. : C 65.47, H 6.55, N 8.81 Found : C 65.88, H 6.44, N 8.78 (10) 1-[2-{5-(3,5-Dichloro-4-hydroxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(36). mp : 165-175°C (recrystallized from N,N-dimethylformamide) NMR (DMSO-d₆, δ) : 1.5-3.6 (13H, m), 5.3 (1H, m), 6.08 (1H, d, J=15Hz), 6.6-7.6 (10H, m), 8.09 (1H, m), 10.75 (1H, s) MASS (m/e) : 485 (M+2), 483 (M⁺), 213 (base) (11) 1-[2-{5-(2-Hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(37). mp : 184-186°C (recrystallized from ethanol) IR (Nujol) : 3400, 3240, 1650, 1605, 1600, 1530, 1090, 1005 cm⁻¹ . NMR (DMSO-d₆, δ) : 1.4-3.6 (13H, m), 3.78 (3H, s), 6.11 (1H, d, J=15Hz), 6.6-7.65 (11H, m), 7.90 (1H, t like), 8.95 (1H, br), 10.75 (1H, s) MASS (m/e) : 445 (M⁺), 226, 213 (base) (12) 1-[2-{5-(3-Hydroxy-4-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine See Example 2-(38). mp : 135-140°C (recrystallized from ethanol) IR (Nujol) : 3350, 1650, 1615, 1590 cm⁻¹ NMR (DMSO-d₆, δ) : 1.4-3.5 (13H, m), 3.75 (3H, s), 6.11 (1H, d, J=15Hz), 6.6-7.7 (11H, m), 7.91 (1H, t like), 9.0 (1H, br), 10.7 (1H, s) MASS (m/e) : 445 (M⁺), 213 (base) Example 8 To a mixture of 1-[2-{5-(4-hydroxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)-piperidine (0.89 g), dry N-methylmorpholine (1.0 g) and dry N,N-dimethylformamide (10 ml) was added slowly acetyl chloride (0.26 g) at 5 to 10°C. After stirring for 1 hour, the reaction mixture was poured into water (50 ml) and stirred for 1 hour. The resulting precipitate was collected, washed with water and then recrystallized from a mixture of ethanol and water (7:3, V/V) to give 1-[2-{5-(4-acetoxy-3-methoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine (0.22 g). See Example 2-(22). mp : 101-105°C (recrystallized from ethanol-water (8:2, V/V)) IR (Nujol) : 3440, 3250, 1760, 1655, 1620, 1560, 1505 cm⁻¹ NMR (DMSO-d₆, δ) : 1.5-2.4 (6H, m), 2.24 (3H, s), 2.6-3.5 (7H, m), 3.81 (3H, s), 6.20 (1H, d, J=15Hz), 6.8-7.7 (11H, m), 8.04 (1H, m), 10.73 (1H, s) MASS (m/e) : 487 (M⁺), 213 (base) Elemental Analysis : C₂₉h₃₃N₃O₄·H₂O Calcd. : C 68.89, H 6.98, N 8.31 Found : C 68.91, H 6.95, N 8.32 Example 9 1-[2-{5-(3-Methoxy-4-propionyloxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine was obtained according to a similar manner to that of Example 8. See Example 2-(23). mp : 157-158°C (recrystallized from ethanol) IR (Nujol) : 3430, 3250, 3060, 1750, 1655, 1620, 1560 cm⁻¹ NMR (DMSO-d₆, δ) : 1.15 (3H, t, J=8Hz), 1.5-2.4 (6H, m), 2.62 (2H, q, J=8Hz), 2.4-3.2 (5H, m), 3.33 (2H, m), 3.82 (3H, s), 6.22 (1H, d, J=15Hz), 6.8-7.7 (11H, m), 8.05 (1H, m), 10.75 (1H, s) MASS (m/e) : 501 (M⁺), 213 (base) Elemental Analysis : C₃₀H₃₅N₃O₄·H₂O Calcd. : C 69.34, H 7.18, N 8.09 Found : C 69.14, H 7.09, N 8.06 Example 10 To a mixture of 1-[2-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine (1 g) and pyridine (10 ml) was added slowly acetyl chloride (0.48 ml) at 5 to 10°C. After 1 hour, the reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride and dried over magnesium sulfate. The solvent was distilled off and the residue was subjected to column chromatography on silica gel and eluted with a mixture of chloroform and methanol (10:1, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was treated with a mixture of fumaric acid (83 mg) and methanol (8 ml) and concentrated under reduced pressure to give white crystals. The crystals were recrystallized from ethanol to give 1-[2-{5-(4-acetoxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine 1/2 fumarate (0.25 g). mp : 202-209°C IR (Nujol) : 3400, 1750, 1680, 1615, 1595, 1565 cm⁻¹ NMR (DMSO-d₆, δ) : 1.6-2.15 (5H, m), 2.32 (3H, s), 2.2-3.6 (8H, m), 4.82 (6H, s), 6.22 (1H, d, J=14Hz), 6-64 (1H, s), 6.7-7.7 (10H, m), 8.29 (1H, m), 10.75 (1H, s) MASS (m/e) : 517 (M⁺), 213 (base) Elemental Analysis : C₃₀H₃₅N₃O₅·1/2Fumarate·3/2H₂O Calcd. : C 63.77, H 6.68, N 6.97 Found : C 63.57, H 6.44, N 6.95 Example 11 1-[2-{5-(3,5-Dimethoxy-4-propionyloxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine 1/2fumarate was obtained according to a similar manner to that of Example 10. mp : 188-192°C (recrystallized from ethanol) IR (Nujol) : 3400, 1745, 1680, 1615, 1595, 1565 cm⁻¹ NMR (DMSO-d₆, δ) : 1.13 (3H, t, J=7Hz), 1.6-2.2 (3H, m), 2.2-3.7 (12H, m), 3.81 (6H, s), 6.21 (1H, d, J=15Hz), 6.62 (1H, s), 6.8-7.6 (10H, m), 8.3 (1H, m), 10.78 (1H, s) MASS (m/e) : 531 (M⁺), 213 (base) Elemental Analysis : C₃₁H₃₇N₃O₅·1/2Fumarate·3/2H₂O Calcd. : C 64.27, H 6.86, N 6.81 Found : C 64.17, H 6.78, N 6.78 Example 12 To a mixture of 1-[2-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine (1.19 g), triethylamine (1.74 ml) and dry N,N-dimethylformamide (12 ml) was added slowly a mixture of ethyl chloroformate (0.33 g) and methylene chloride (0.5 ml) at 0 to 5°C. Similar work up gave 1-[2-{5-(4-ethoxycarbonyloxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine (0.74 g). See Example 2-(24). mp : 90-98°C (recrystallized from ethanol-water (8:2, V/V)) IR (Nujol) : 3360, 3300, 1750, 1640, 1590, 1130, 1000, 735 cm⁻¹ NMR (DMSO-d₆, δ) : 1.28 (3H, t, J=8Hz), 1.5-3.6 (13H, m), 3.81 (6H, s), 4.23 (2H, q, J=8Hz), 6.21 (1H, d, J=15Hz), 6.8-7.7 (10H, m), 8.05 (1H, m), 10.71 (1H, s) MASS (m/e) : 547 (M⁺), 228, 213 (base) Elemental Analysis : C₃₁H₃₇N₃O₆·2.5H₂O Calcd. : C 62.82, H 7.14, N 7.09 Hound : C 62.74, H 6.93, N 7.05 Example 13 The following compounds were obtained according to a similar manner to that of Example 12. (1) 1-[4-{5-(4-Ethoxycarbonyloxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)piperidine See Example 2-(25). mp : 90-98°C (recrystallized from ethanol-water (8:2, V/V)) IR (Nujol) : 3380, 3250, 1750, 1655, 1620, 1595, 1555, 1130, 1050, 1000, 735 cm⁻¹ NMR (DMSO-d₆, δ) : 1.27 (3H, t, J=8Hz), 1.4-3.7 (17H, m), 3.72 (6H, s), 4.23 (2H, q, J=8Hz), 6.20 (1H, d, J=15Hz), 6.8-7.75 (10H, m), 8.10 (1H, m), 10.76 (1H, s) MASS (m/e) : 575 (M⁺), 531, 503, 285, 233, 213 (base) Elemental Aanlysis : C₃₃H₄₁N₃O₆·3/2ethanol Calcd. : C 67.01, H 7.81, N 6.52 Found : C 66.39, H 7.74, N 6.52 (2) 1-[4-{5-(3,5-Dimethoxy-4-propionyloxyphenyl)-(2E,4E)-2,4-pentadienoylamino}butyl]-4-(3-indolyl)piperidine hydrochloride mp : 215-220°C (recrystallized from acetonitrile) IR (Nujol) : 3250, 2650, 2500, 1760, 1650, 1595, 1130, 1010, 850, 750 cm⁻¹ NMR (CDCl₃, δ) : 1.29 (3H, t, J=8Hz), 2.65 (2H, q, J=8Hz), 1.5-3.7 (17H, m), 3.80 (6H, s), 6.35 (1H, d, J=15Hz), 6.6-7.7 (10H, m), 7.9 (1H, m), 9.05 (1H, m), 11.3 (1H, m) MASS (m/e) : 559 (M⁺), 503, 233, 213 (base) (3) 1-[2-[5-{3,4-bis(Ethoxycarbonyloxy)phenyl}-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine See Example 2-(39). mp : 135-137°C (recrystallized from a mixture of water and ethanol) IR (Nujol) : 3500, 3350, 1775, 1650, 1620, 1000 cm⁻¹ NMR (DMSO-d₆, δ) : 1.30 (6H, t, J=8Hz), 1.3-3.5 (13H, m), 4.30 (4H, q, J=8Hz), 6.25 (1H, d, J=15Hz), 6.6-7.7 (11H, m), 8.08 (1H, m), 10.73 (1H, s) MASS (m/e) : 529 (M⁺-46), 457, 285 (base), 213 Example 14 To a mixture of 1-[2-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine (2.0 g), triethylamine (2.9 ml) and dry N,N-dimethylformamide (20 ml) was added slowly a solution of acetylchloride (0.5 g) in methylene chloride (1.0 ml) at 0 to 5°C. After 1 hour, the reaction mixture was poured into water (200 ml) and stirred for 1 hour. The resulting precipitate was collected, washed with water and air-dried at ambient temperature. The precipitate was subjected to column chromatography on silica gel (60 g) and eluted with a mixture of chloroform and methanol (20:1, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give pale yellow crystals of 1-[2-{5-(4-acetoxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine (1.35 g). See Example 2-(30). mp : 169-172°C IR (Nujol) : 3380, 3320, 1755, 1650, 1620, 1595, 990, 745 cm⁻¹ NMR (CDCl₃, δ) : 1.5-3.6 (13H, m), 2.32 (3H, s), 3.82 (6H, s), 6.0 (1H, d, J=15Hz), 6.34 (1H, m), 6.7-7.7 (10H, m), 8.32 (1H, m) MASS (m/e) : 517 (M⁺), 213 (base) Elemental Analysis : C₃₀H₃₅N₃O₅ Calcd. : C 69.61, H 6.82, N 8.12 Found : C 69.35, H 6.82, N 8.02 Example 15 To a stirred mixture of 5-[3,5-dimethoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoic acid (1.35 g) and triethylamine (1.17 ml) in dry N,N-dimethylformamide (8 ml) was added slowly diphenyl phosphinic chloride (0.97 g) at -10 to -15°C under an inert atmosphere. After being stirred for 1 hour, a solution of 1-(2-aminoethyl)-4-(3-indolyl)piperidine (0.97 g) in dry N,N-dimethylformamide (8 ml) was added slowly to the reaction mixture at the same temperature. After being stirred for 40 minutes at the same temperature, the reaction mixture was poured into ice-water (160 ml) and extracted with ethyl acetate. The extract was washed with a saturated sodium chloride solution and dried over magnesium sulfate. The solvent was evaporated to give syrup of 1-[2-[5-[3,5-dimethoxy-4-{(2-methoxyethoxy)methoxy}phenyl]-(2E,4E)-2,4-pentadienoylamino]ethyl]-4-(3-indolyl)piperidine (1.97 g). See Example 2-(11). IR (Nujol) : 3300, 1650, 1610, 1580, 1125, 990, 960, 845, 745 cm⁻¹

Claims: Claims for the following Contracting States : AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A compound of the formula : wherein R¹ is phenyl substituted with substituent(s) selected from the group consisting of hydroxy, C₁-C₆ alkoxy(C₁-₆)alkoxy(C₁-C₆)alkoxy, C₁-C₆ alkyl, C₁-C₆ alkanoyloxy, C₁-C₆ alkoxycarbonyloxy, halogen and C₁-C₆ alkoxy, A is C₁-C₆ alkylene, and B is vinylene, propenylene, butenylene, pentenylene, butadienylene or pentadienylene, and a pharmaceutically acceptable salt thereof. 2. A compound of claim 1, wherein R¹ is phenyl substituted with mono-, or dihydroxy and mono-, or di(C₁-C₆)alkoxy. 3. A compound of claim 2, which is 1-[2-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 4. A compound of claim 1, wherein R¹ is phenyl substituted with mono, or di(C₁-C₆)alkanoyloxy and mono-, or di(C₁-C₆)alkoxy, or with mono-, or di(C₁-C₆)alkoxycarbonyloxy and mono-, or di(C₁-C₆)alkoxy. 5. A compound of claim 4, which is 1-[2-{5-(4-acetoxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 6. A compound of claim 4, which is 1-[2-{5-(4-ethoxycarbonyloxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 7. A process for preparing a compound of the formula : wherein R¹ is phenyl substituted with substituent(s) selected from the group consisting of hydroxy, C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, C₁-C₆ alkyl, C₁-C₆ alkanoyloxy, C₁-C₆ alkoxycarbonyloxy, halogen and C₁-C₆ alkoxy, A is C₁-C₆ alkylene, and B is vinylene, propenylene, butenylene, pentenylene, butadienylene or pentadienylene, or its salt, which comprises a) reacting a compound of the formula : wherein A is as defined above, or its reactive derivative at the amino group or a salt thereof with a compound of the formula : R¹-B-COOH wherein R¹ and B are each as defined above, or its reactive derivative at the carboxy group or a salt thereof to give a compound of the formula : wherein R¹, A and B are each as defined above, or its salt, or b) subjecting a compound of the formula : wherein R 1 / a is phenyl substituted with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and halogen, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkyl, or with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt to elimination reaction of C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkyl to give a compound of the formula : wherein R 1 / b is phenyl substituted with hydroxy, with hydroxy and halogen, with hydroxy and C₁-C₆ alkyl, or with hydroxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt, or c) acylating a compound of the formula : wherein R 1 / c is phenyl substituted with hydroxy, or with hydroxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt to give a compound of the formula : wherein R 1 / d is phenyl substituted with C₁-C₆ alkoxycarbonyloxy, or with acyloxy selected from C₁-C₆ alkanoyloxy and C₁-C₆ alkoxycarbonyloxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt. 8. A pharmaceutical composition comprising a compound of claim 1, as an active ingredient, in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient. 9. A compound of claim 1 for use as a medicament. 10. Use of a compound of claim 1 and a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of allergic disease in human beings or animals. Claims for the following Contracting State : ES 1. A process for preparing a compound of the formula : wherein R¹ is phenyl substituted with substituent(s) selected from the group consisting of hydroxy, C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, C₁-C₆ alkyl, C₁-C₆ alkanoyloxy, C₁-C₆ alkoxycarbonyloxy, halogen and C₁-C₆ alkoxy, A is C₁-C₆ alkylene, and B is vinylene, propenylene, butenylene, pentenylene, butadienylene or pentadienylene, or its salt, which comprises a) reacting a compound of the formula : wherein A is as defined above, or its reactive derivative at the amino group or a salt thereof with a compound of the formula : R¹-B-COOH wherein R¹ and B are each as defined above, or its reactive derivative at the carboxy group or a salt thereof to give a compound of the formula : wherein R¹, A and B are each as defined above, or its salt, or b) subjecting a compound of the formula : wherein R 1 / a is phenyl substituted with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and halogen, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkyl, or with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt to elimination reaction of C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkyl to give a compound of the formula : wherein R 1 / b is phenyl substituted with hydroxy, with hydroxy and halogen, with hydroxy and C₁-C₆ alkyl, or with hydroxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt, or c) acylating a compound of the formula : wherein R 1 / c is phenyl substituted with hydroxy, or with hydroxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt to give a compound of the formula : wherein R 1 / d is phenyl substituted with C₁-C₆ alkoxycarbonyloxy, or with acyloxy selected from C₁-C₆ alkanoyloxy and C₁-C₆ alkoxycarbonyloxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt. 2. A process of claim 1, wherein R¹ is phenyl substituted with mono-, or dihydroxy and mono-, or di(C₁-C₆)alkoxy. 3. A process of claim 2 for preparing 1-[2-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 4. A process of claim 1, wherein R¹ is phenyl substituted with mono-, or di(C₁-C₆)alkanoyloxy and mono-, or di(C₁-C₆)alkoxy, or with mono-, or di(C₁-C₆)alkoxycarbonyloxy and mono-, or di(C₁-C₆)alkoxy. 5. A process of claim 4 for preparing 1-[2-{5-(4-acetoxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 6. A process of claim 4 for preparing 1-[2-{5-(4-ethoxycarbonyloxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. Claims for the following Contracting State : GR 1. A process for preparing a compound of the formula [I] : wherein R¹ is phenyl substituted with substituent(s) selected from the group consisting of hydroxy, C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, C₁-C₆ alkyl, C₁-C₆ alkanoyloxy, C₁-C₆ alkoxycarbonyloxy, halogen and C₁-C₆ alkoxy, A is C₁-C₆ alkylene, and B is vinylene, propenylene, butenylene, pentenylene, butadienylene or pentadienylene, or its salt, which comprises a) reacting a compound of the formula : wherein A is as defined above, or its reactive derivative at the amino group or a salt thereof with a compound of the formula : R¹-B-COOH wherein R¹ and B are each as defined above, or its reactive derivative at the carboxy group or a salt thereof to give a compound of the formula : wherein R¹, A and B are each as defined above, or its salt, or b) subjecting a compound of the formula : wherein R 1 / a is phenyl substituted with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and halogen, with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkyl, or with C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkoxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt to elimination reaction of C₁-C₆ alkoxy(C₁-C₆)alkoxy(C₁-C₆)alkyl to give a compound of the formula : wherein R 1 / b is phenyl substituted with hydroxy, with hydroxy and halogen, with hydroxy and C₁-C₆ alkyl, or with hydroxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt, or c) acylating a compound of the formula : wherein R 1 / c is phenyl substituted with hydroxy, or with hydroxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt to give a compound of the formula : wherein R 1 / d is phenyl substituted with C₁-C₆ alkoxycarbonyloxy, or with acyloxy selected from C₁-C₆ alkanoyloxy and C₁-C₆ alkoxycarbonyloxy and C₁-C₆ alkoxy, and A and B are each as defined above, or its salt. 2. A process of claim 1, wherein R¹ is phenyl substituted with mono-, or dihydroxy and mono-, or di(C₁-C₆)alkoxy. 3. A process of claim 2 for preparing 1-[2-{5-(4-hydroxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 4. A process of claim 1, wherein R¹ is phenyl substituted with mono-, or di(C₁-C₆)alkanoyloxy and mono-, or di(C₁-C₆)alkoxy, or with mono-, or di(C₁-C₆)alkoxycarbonyloxy and mono-, or di(C₁-C₆)alkoxy. 5. A process of claim 4 for preparing 1-[2-{5-(4-acetoxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 6. A process of claim 4 for preparing 1-[2-{5-(4-ethoxycarbonyloxy-3,5-dimethoxyphenyl)-(2E,4E)-2,4-pentadienoylamino}ethyl]-4-(3-indolyl)piperidine. 7. Modification of the process claimed in claim 1 which is characterised by bringing a compound of formula I, or a non-toxic salt thereof, produced by a process claimed in claim 1, into pharmaceutically acceptable form by admixture or presentation of said compound with a pharmaceutically acceptable diluent or carrier.

Inventors: MANABE, TAKASHI, MATSUDA, HIROSHI, MATSUO, MASAAKI, SHIGENAGA, SHINJI
Applicants: FUJISAWA PHARMACEUTICAL CO., LTD.
Application year: 1989
Main classification: C07D401
IPC codes: A61K31, C07D401, A61P37