Cosmetic compostition

Abstract: An acid-soap complex comprises: (i) at least two 2-hydroxyalkanoic acid moieties of carbon chain length C m and C n respectively, where m and n have the same or different values, and each is an integer of from 6 to 28; and (ii) a cation; the complex having an elemental analysis of: (C m H 2m-½ 0₃) (C n H 2n-½ 0₃) M where M is the cation. A process for preparing the complex and its use in compositions suitable for topical application to human skin, hair and nails is also claimed.

Description: FIELD OF INVENTION The invention relates to a cosmetic composition comprising acid-soap complexes of 2-hydroxyalkanoic acids with a cation and to a process for preparing such compositions. BACKGROUND Certain 2-hydroxyalkanoic acids are known for their skin benefits when included in compositions for topical application to the skin. Such benefits include both increased elasticity of the skin, particularly the stratum corneum, and improved appearance. However, when included in skin cosmetic formulations, 2-hydroxyalkanoic acids are generally efficacious only at low pH. At high pH values, the efficacy of these acids appears to be reduced. Low pH formulations are less acceptable to consumers than are formulations of closer to neutral pH, in view of the possibility that they may cause irritation to sensitive skin and to the eyes. PRIOR ART EP-A 0 007 785 (Unilever) discloses skin treatment compositions incorporating α-hydroxycaproic acid or α-hydroxycaprylic acid or mixtures thereof, the compositions having a pH value of less than 7, usually from pH values of from 2 to 4. The pH value of the composition in Example 2 is likely to be below 3.85, the pK a of α-hydroxycaprylic acid. It is proposed in US 4 105 782 (Yu & Van Scott) to use amides or ammonium salts of α-hydroxyacids in the treatment of acne or dandruff and, in the Yu & Van Scott patents, US 4 105 783 and US 4 197 316, to use such compounds in the treatment of dry skin. US 4 234 599 (Yu & Van Scott) discloses the use of α-hydroxyacids, and their esters or amine salts in the treatment of keratoses. In all of these US patents, the maximum carbon chain length is 6. In none of them is there any reference to the incorporation of alkali metal ions that could form complexes with the acids. In US 4 363 815 (Yu & Van Scott) it is proposed to use α-hydroxyacids or β-hydroxyacids or ketoacids or their derivatives, including inorganic salts, in a composition for treating skin conditions. Suggested cations are calcium and magnesium, neither of which forms an acid-soap complex with -hydroxyacids. According to GB 1 471 679 (Avon), it is known to use alkali metal salts of C₂-C₅ α-hydroxycarboxylic acids in moisturising compositions, but there is no mention of acid-soap complexes of the corresponding acids with alkali metal ions. EP-A-O 086 070 (Unilever) discloses skin treatment compositions comprising 0.1 to 20% by weight of a substituted 2 - hydroxyoctanoic acid or 2 - ketooctanoic acid neutralised by using a neutralising agent having a cation with an ionic radius of at least 100 pm. The neutralising agent is used in an amount sufficient to adjust the pH value of the composition to a value of from 3 to 7. In DE 2 110 993 (Henkel), there are disclosed alkali metal salts of C₄-C₁₀ α-hydroxycarboxylic acids, and the sodium salt of α-hydroxycaprylic acid is mentioned. These salts are incorporated in amounts from 3-30% into washing and cleaning compositions and are said to confer improved storage stability. However, there is no mention of the pH values at which an acid-soap complex would form. GB 1 232 569 (Medisan) discloses a skin-treating composition incorporating lactic acid and sodium chloride. There is a suggestion that a complex forms between urea and lactic acid, but no indication that the pH value is suitable for the formation of a sodium-lactic acid complex or salt. Indeed, it is highly improbable that an acid-soap complex would be formed. DE 2 924 452 (Stange B) discloses a meat additive containing C₁ to C₆ hydroxycarboxylic acids and their sodium partial or full salts. However, there is no suggestion that an acid-soap complex will form. It has now surprisingly been found that when 2-hydroxyalkanoic acids are complexed with certain alkali metal ions under certain very special conditions, the resulting acid-soap complexes are capable of forming at acid pH, compositions that are storage stable even at pH values around 7. It has also been discovered that topical application of the compositions to skin results in an increase in skin flexibility, with the result that the pliability of the skin is improved. This improvement is greater than that which can be obtained when using the corresponding salt of the free acid. The complex can be used in an insoluble form and a surprising benefit can be seen. A further advantage resides in employing the composition for skin treatment at a pH value nearer the natural pH of human skin, which is higher than that associated with the use of corresponding free acid-containing composition. Compositions containing the acid-soap complex accordingly produce few of the common consumer-related problems associated with low pH, such as eye irritation. The invention is accordingly concerned with compositions containing the complex which are suited to topical application to human skin, hair and nails. DISCLOSURE OF THE INVENTION The 2-hydroxyalkanoic acid-soap complex The 2-hydroxyalkanoic acid-soap complex has an elemental analysis of: (C m H 2m-½ 0₃) (C n H 2n-½ 0₃) M (1) where m and n have the same or different values, and each is an integer of from 6 to 28, and M is a cation. When the value of m or n is less than 6, the corresponding acid-soap complex is not formed to any significant extent, and when the value of m or n is greater than 28, the usefulness of the complex, as in the topical treatment of skin, which will be described later, is negligible. The cation M is a monovalent ion chosen from sodium or lithium. The 2-hydroxyalkanoic acid-soap complex is characterised as shown in the Table 1 below which gives typical values of selected acid-soap complexes, together with, by way of comparison, the free acid and corresponding simple salt. COMPOUND ¹³C RESONANCE (ppm) IR ABSORPTION C-1 C-2 C-ω ν(C=O) (cm⁻¹) C₈ acid 177.5 70.2 13.6 1710 Sodium salt of C₈ acid 183.5 72.9 14.8 1580 Sodium acid-soap complex of C₈ acid 180.2 75.0 15.7 1745 Sodium acid-soap complex of C₆ acid 180.2 74.7 15.6 1745 Sodium acid-soap complex of C₁₀ acid 180.2 74.8 15.3 1746 Sodium acid-soap complex of C₁₂ acid 180.2 74.7 15.3 1745 where C-1, C-2 and C-ω are defined as follows: C₆ acid = 2-hydroxyhexanoic acid C₈ acid = 2-hydroxyoctanoic acid C₁₀ acid = 2-hydroxydecanoic acid C₁₂ acid = 2-hydroxydodecanoic acid The ¹³C resonance of C-1 and the IR absorption of the carbonyl (C=0) bond are the most important from the point of view of analytical characterisation of these compounds. By Electron Spectroscopy for Chemical Analysis (ESCA), the sodium acid-soap complex of 2-hydroxy octanoic acid was found to have a carbon:oxygen:sodium ratio of m+n:6:1. This is in agreement with the elemental analysis from which was derived the formula: (C m H 2m-½ 0₃) (Cn H 2n-½ 0₃) M (1) The analytical data presented here confirm that there are physical differences between the structures of the free acid, the sodium salt and the sodium acid-soap complex. PROCESS FOR PREPARING THE ACID-SOAP COMPLEX The process according to the invention comprises contacting an aqueous solution of one or two 2-hydroxyalkanoic acids each having from 6 to 28 carbon atoms, with a cation at a pH value of 3.5 or more, and less than 7, to form a precipitate, and separating said precipitate to yield an acid-soap complex having an elemental analysis of : (C m M 2m-½ 0₃) (C n H 2n-½ 0₃) M , Preferably the cation is sodium, potassium or ammonium. The preferred process comprises the steps of: (a) dissolving the 2-hydroxyalkanoic acid(s) in water; (b) adding to the solution so formed a cation-containing aqueous alkali to adjust the pH to 4, to form a precipitate; and (c) filtering off the precipitate, washing with water and drying to obtain the complex as a fine white powder. Optionally, step (b) may be followed by the addition of cations in aqueous solution and readjusting to pH 4 with aqueous alkali. COMPOSITION The invention provides a composition for topical application to human skin which comprises the acid-soap complex as herein defined, together with a cosmetically acceptable vehicle and optionally conventional cosmetic adjuncts. The Acid-Soap Complex The acid-soap complex present in the composition according to the invention has the structure (1) as herein defined. The preferred acid-soap complex is one in which m and n in structure (1) have the same value. Ideally this value is 8, but complexes where both m and n have a value of from 6 to 12 are also surprisingly effective in their skin benefit properties. The cation M in structure (1) is sodium or lithium, the preferred acid soap complex having the empirical formula C₁₆ H₃₁ O₆ M. The acid-soap complex is present in the composition according to the invention in an amount of from 0.1 to 90%, preferably from 0.5 to 10% and ideally from 1 to 5% by weight of the composition. The Cosmetically Acceptable Vehicle The selection of a suitable vehicle will depend on the required product form of the composition. Typically, the vehicle will be chosen from diluents, dispersants or carriers for the acid-soap complex, so as to ensure an even distribution of the complex when applied to the skin. Compositions according to this invention can include water as a vehicle, usually with at least one other cosmetically-acceptable vehicle. Vehicles other than water that can be used in compositions according to the invention can include liquids or solids as emollients, solvents, humectants, thickeners and powders. Examples of each of these types of vehicles, which can be used singly or as mixtures of one or more vehicles, are as follows: Emollients, such as stearyl alcohol, glyceryl monoricinoleate, glyceryl monostearate, propane-1,2-diol, butane-1,3-diol, mink oil, cetyl alcohol, isopropyl isostearate, stearic acid, isobutyl palmitate, isocetyl stearate, oleyl alcohol, isopropyl laurate, hexyl laurate, decyl oleate, octadecan-2-ol, isocetyl alcohol, eicosanyl alcohol, behenyl alcohol, cetyl palmitate, silicone oils such as dimethylpolysiloxane, di-n-butyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, butyl stearate, polythylene glycol, triethylene glycol, lanolin, cocoa butter, corn oil, cotton seed oil, tallow, lard, olive oil, palm kernel oil, rapeseed oil, safflower seed oil, soybean oil, sunflower seed oil, olive oil, sesame seed oil, coconut oil, arachis oil, castor oil, acetylated lanolin alcohols, petroleum, mineral oil, butyl myristate, isostearic acid, palmitatic acid, isopropyl linoleate, lauryl lactate, myristyl lactate, decyl oleate, myristyl myristate; Propellants, such as trichlorofluoromethane, dichlorodifluoromethane, dichlorotetrafluoroethane, monochlorodifluoromethane, trichlorotrifluoroethane, propane, butane, isobutane, dimethyl ether, carbon dioxide, nitrous oxide; Solvents, such as ethyl alcohol, methylene chloride, isopropanol, acetone, castor oil, ethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, dimethyl sulphoxide, dimethyl formamide, tetrahydrofuran; Humectants, such as glycerin, sorbitol, sodium 2-pyrrolidone-5-carboxylate, soluble collagen, dibutyl phthalate, gelatin; Powders, such as chalk, talc, fullers earth, kaolin, starch, gums, colloidal silicon dioxide, sodium polyacrylate, tetra alkyl and/or trialkyl aryl ammonium smectites, chemically modified magnesium aluminium silicate, organically modified montmorillonite clay, hydrated aluminium silicate, fumed silica, carboxyvinyl polymer, sodium carboxymethyl cellulose, ethylene glycol monostearate. The cosmetically acceptable vehicle will usually form from 10 to 99.9%, preferably from 50 to 99% by weight of the composition, and can, in the absence of other cosmetic adjuncts, form the balance of the composition. Cosmetic Adjuncts Examples of conventional adjuncts which may optionally be employed include volatile silicones; silicone polymers; preservatives, such as para-hydroxy benzoate esters; humectants, such as butane-1,3-diol, glycerol, sorbitol, polyethylene glycol; stabilisers, such as sodium chloride or ammonium chloride; buffer system, such as lactic acid together with a base such as sodium hydroxide; oils and waxes, such as avocado oil, Evening Primrose oil, sunflower oil, beeswax, ozokerite wax, paraffin wax, lanolin, lanolin alcohol; emollients; thickeners; activity enhancers; colourants; perfumes; emulsifiers; sunscreens; bactericides and water. Cosmetic adjuncts can form up to 50% by weight of the composition and can conveniently form the balance of the composition. pH The composition according to the invention has a pH value of from 3.5 to <7. It is apparent that difficulty may be experienced in obtaining the acid-soap complex, or retaining it as such, in the composition if the pH value is outside this range. At pH values below 3.5, there is tendency for the free acid to exist rather than the acid soap complex, and at pH values of 7 and above, there is a tendency for the corresponding salt to form rather than the complex. Process for preparing the composition The invention also provides a process for the preparation of a composition for topical application to human skin which comprises the step of incorporating the acid-soap complex, as herein defined, in a preformed state into the composition, together with a cosmetically acceptable vehicle. The invention also provides a process for the preparation of a composition for topical application to human skin which comprises the steps of incorporating into the composition: (a) one or two 2-hydroxy alkanoic acids having from 6 to 28 carbon atoms to provide a solution of said acid(s): (b) a monovalent cation to react with said acid at a pH value of from 3.5 to <7 to form the corresponding acid-soap complex in situ in the composition; and (c) a cosmetically acceptable vehicle. PRODUCT FORMS AND PACKAGING The topical skin treatment composition of the invention can be formulated as a fluid, for example in a product such as a lotion, with or without an applicator such as a roll-ball applicator, or a propellant-driven aerosol device or a container fitted with a pump to dispense the composition, for example as a mousse or simply for storage in a non-deformable bottle or squeeze container. Alternatively, the composition of the invention may be solid or semi-solid, for example a cream or ointment, for use in conjunction with a suitable applicator, or simply for storage in a tube or lidded jar. The invention accordingly also provides a closed container containing a cosmetically acceptable composition as herein defined. EVIDENCE OF THE SUPERIORITY OF THE INVENTION The following experiments compare the extensibility of the stratum corneum when treated either with the acid-soap complex of the invention or with the corresponding salt or free acid. Measurements of extensibility were made as described in EP-A 0 007 785. For each sample of stratum corneum, an extensibility ratio was calculated as the ratio of the extensibility measurement for a treated sample to the measurement for an untreated control sample. Experiment 1 An in vitro extensibility study was carried out on stratum corneum samples from guinea pig foot pads. Measurements of extensibility were made at a relative humidity of 61% and a temperature of 20°C on batches of six samples of stratum corneum. Samples were treated with 1% by weight aqueous solution of the sodium acid-soap complexes of 2-hydroxyoctanoic acid maintained at pH 4.0 with the corresponding base (hydroxide), and then compared with samples treated with 1% w/v aqueous solutions of sodium 2-hydroxyoctanoate at pH 7 and 10.3. These experiments were repeated using the same materials as 2% w/v aqueous solutions. The results are detailed in Table 2 below. From these results it is apparent that the extensibility ratio of the stratum corneum was significantly greater at the 95% confidence level in the batches treated with acid-soap complex solutions than in the batches treated with the salt solution. Experiment 2 This experiment compares the increase in extensibility conferred in vitro by solutions of the acid-soap complex and the free acid. The tests were carried out on heat-separated guinea pig footpads which were immersed in the required solution at specified pH values. Extensibility ratios for each group of samples are shown in Table 3 below. Active pH Extensibility Ratio % Increase of Mean Ratio 1% acid 5.0 (b) 0.82 ± 0.18 1% complex 5.0 (a) 1.22 ± 0.20 48.8 2% acid 5.0 (b) 0.86 ± 0.22 2% complex 5.0 (a) 1.53 ± 0.34 77.9 1% acid 6.0 (b) 0.94 ± 0.08 1% complex 6.0 (a) 1.33 ± 0.21 41.5 2% acid 6.0 (b) 0.97 ± 0.10 2% complex 6.0 (a) 1.27 ± 0.12 30.9 acid = free acid (2-hydroxyoctanoic acid) complex = sodium acid soap of 2-hydroxyoctanoic acid (C₈) Note : the pH value was adjusted to the values shown above using either (a) sodium hydroxide or (b) triethanolamine. The extensibility ratios for the 1% complex solution were significantly greater, at the 95% confidence level, than those of the 1% free acid solution at both pH 5 and 6. The extensibility ratios for the 2% complex solution were significantly greater, at the 99% confidence level, than those of the 2% free acid solution at both pH 5 and 6. These results clearly indicate that the complex has a greater effect on extensibility in vitro than does the free acid, in the natural pH range of skin. Experiment 3 This experiment compares the extensibility increase conferred in vitro by solutions of the acid-soap and the free acid, in the presence of 13.5% w/w butane-1,3-diol, as an example of an activity enhancer. The tests were carried out on heat-separated guinea pig footpads which were immersed in the required solution at specified pH values. Extensibility ratios for each group of samples are shown in Table 4 below. Active pH Extensibility Ratio % Increase of Mean Ratio 1% acid 5.0 (b) 1.07 ± 0.30 1% complex 5.0 (a) 2.25 ± 0.73 110.3 1% acid 6.0 (b) 1.68 ± 0.46 1% complex 6.0 (a) 2.51 ± 0.54 49.4 acid = free acid (2-hydroxyoctanoic acid) complex = sodium acid soap of 2-hydroxyoctanoic acid (C₈) Note : the pH value was adjusted to the value shown using either (a) sodium hydroxide, or (b) triethanolamine. At both pH 5 and pH 6, the extensibility ratios for the complex in solution were significantly greater, at the 95% confidence level, than those of the free acid solution. These results indicate that, for these solutions containing butane-1,3-diol, the acid-soap complex has a greater effect on extensibility in vitro than does the free acid. EXAMPLES The invention is further illustrated by the following examples. Example 1 The example illustrates an oil-continuous (W/O) cream containing the sodium acid-soap complex of the C₈ hydroxy acid. Ingredients % w/w Silicones 20.00 Sodium chloride 2.00 Sodium acid-soap complex of 2-hydroxyoctanoic acid 1.00 Whitener 0.15 Preservatives 0.36 Lactic acid 5.00 Sodium hydroxide 1.30 Water 70.19 100.00 The skin cream, having a pH value of 4, is made by the process as herein described by adding gradually to a mixture of silicones, whitener and preservatives on aqueous mixture of the remaining ingredients and homogenising. Example 2 The example illustrates a gel suitable for treating hair containing the sodium acid-soap complex of the C₁₀ hydroxy acid. Ingredients %w/w Emulsifiers 20.00 Silicone oil 20.00 Sodium acid-soap complex of 2-hydroxy decanoic acid 1.00 Sodium hydroxide 4.55 Butane-1,3-diol 11.00 Lactic acid 5.00 Water 38.45 100.00 Example 3 This example illustrates a lotion suitable for treatment of nails containing the sodium acid-soap complex of the C₁₆ hydroxy acid. Ingredient % Sodium acid-soap complex of 2-hydroxy hexadecanoic acid 6.00 Sodium hydroxide 1.50 Ethanol 10.00 Propane-1,2-diol 55.00 Water 27.50 100.00 This lotion, having a pH value of 4.4, is made by the process, as herein described, by homogenising the mixture of the ingredients. Example 4 This example illustrates a further w/o skin cream, in which the acid-soap complex is formed in situ in the composition . Ingredients % w/w Silicones 24.00 Sodium chloride 2.00 2-hydroxyoctanoic acid 1.00 Lactic acid 5.00 Sodium hydroxide 2.00 Humectants 5.00 Whitener 0.15 Preservatives 0.05 Evening Primrose Oil 3.00 Sunscreens 4.00 Bactericides 0.30 Water 53.50 100.00 The skin cream, having a pH value of 4, is made by the process as herein described by adding gradually to a mixture of silicones, whitener and preservatives a mixture of the remaining ingredients and homogenising.

Claims: A cosmetic composition for topical application to human skin, hair and nails which comprises: (a) from 0.1 to 90% by weight of an acid soap complex comprising: (i) at least two 2-hydroxyalkanoic acid moieties of carbon chain length C m and C n , respectively, where m and n have the same or different values, and each is an integer of from 6 to 28; and (ii) a monovalent cation chosen from sodium and lithium, the complex having an elemental analysis of: (C m H 2m-½ 0₃) (C n H 2n-½ 0₃) M where M is the cation; and (b) from 10 to 99.9% by weight of a cosmetically acceptable vehicle for the complex, the composition having a pH value of from 3.5 to less than 7. A cosmetic composition according to claim 1, in which m and n have the same value and each is an integer of from 6 to 12. A cosmetic composition according to claim 1 or 2, in which m and n are each 8, the complex having the empirical formula: C₁₆ H₃₁ 0₆ M. A cosmetic composition according to any preceding claim, which is in the form of an emulsion. A process for preparing the cosmetic composition according to any preceding claim, which comprises the steps of (i) forming an aqueous solution of one or two 2-hydroxyalkanoic acids each having from 6 to 28 carbon atoms; (ii) contacting said solution with a cation chosen from sodium or lithium to react with said acid(s) at a pH value of from 3.5 to <7 to form the corresponding acid-soap complex in situ in the composition; and (iii) incorporating a cosmetically-acceptable vehicle with the said complex, to provide a composition suitable for topical application to human skin, hair and nails.

Inventors: HAGAN DESMOND BERNARD, SPIEGEL UDO, HAGAN, DESMOND BERNARD, SPIEGEL, UDO
Applicants: UNILEVER NV, UNILEVER PLC, UNILEVER N.V.
Application year: 1989
Main classification: A61K7
IPC codes: A61K8, A61Q3, A61Q19, A61Q17, A61Q5, C07C59