HEMOLYSIS INHIBITOR AND PLASTICIZER

Abstract: A triglyceride of formula (I) is used as a haemolysis inhibitor: where R1-R3 are 1-20C aliphatic hydrocarbyl gps. and the total number of carbon atoms in R1+R2+R3 is 10-36C (pref. R1-R3 are 1-10C and R1+R2+R3 is 10-30C). The triglyceride (I) may be incorporated in a polymer resin for medical uses, esp. a polyvinyl chloride resin, which may also contain a plasticiser (pref. 1-20% (esp. 3-10%) by wt. (I) and 10-45% plasticiser). The plasticiser is pref. of low solubility such as a di-n-alkyl phthalate, trialkyl trimellitate or tetraalkyl pyromellitate. The polymer resin may be used in medical appts. The triglyceride (I) may also be used as a blood preservation pref. at 10 micro M - 10mM (esp. 30 microM - 5mM).

Description: Technical Field: This invention relates to a a plasticizer. More particularly, this invention relates to the use of a triglyceride compound as a plasticizer exhibiting no toxicity and possessing highly desirable compatibility with vinyl chloride type resins and to vinyl chloride type resin composition for medical appliances and medical implements which make use of the plasticizer. Background Art: When blood flows out of the blood vessel, it begins to show a visible sign of coagulation within 10 to 20 minutes' exposure to the ambience. The clot which is formed by the coagulation is the final product of a series of chemical reactions which proceed during the conversion of fibrinogen into fibrin. The fibrin are interconnected and, during the course of the interconnection, erythrocytes are entrapped in the clot. In order for the blood for transfusion to retain its original liquid state, therefore, a measure to preclude the normal reactions responsible for the hemal coagulation must be taken during the extraction of the blood from a donor. Heretofore, the practice of adding a liquid anticoagulant as a blood preserving liquid to the freshly extracted blood has been in vogue. The liquid anticoagulant which is in popular use nowadays is intended to effect the preclusion of the hemal coagulation by chelating the calcium ion which constitutes an important factor during the course of coagulation. Incidentally, the blood for transfusion secured as described above is treated, when necessary, for separation of some of the components thereof and then is placed as in a blood bag, for example, to be preserved until use. When whole blood or a blood component such as concentrated red cells (CRC) is preserved for a long time, there ensues the so-called hemolysis, i.e. a phenomenon which involves external liberation of hemoglobin from the erythrocyte. As main causes for the hemolysis, there can be cited the change in the pressure of osmosis due to a difference in the ion composition in the blood, the difference in the pressure of colloidal osmosis due to such proteinaceous components as hemoglobin, the change in membrane proteins and lipids of erythrocytes, the hindrance to the active transport of Na⁺ and K⁺ and the actions of medicines and poisons. The most important factor consists in the liquid anticoagulant to be used. Thus, numerous efforts have been devoted to improve the liquid anticoagulants. All the liquid anticoagulants currently in use are claimed to produce an anticoagulant action and an action for protection of erythrocytes as well. In the liquid anticoagulants of this type, however, the function as a protector for erythrocytes has not yet reached a point where it deserves to be called sufficient. It is likewise important that the container such as the blood bag for preserving the collected blood should be inactive to blood components. In the blood containers and other similar medical implements which are currently in use, those made of flexible vinyl chloride resin are predominant. The di-2-ethylhexyl phthalate (DOP) which is contained as a plasticizer in the flexible vinyl chloride resin for such medical implements possesses a large capacity for migration. It is known that when the flexible vinyl chloride resin is exposed to blood, the di-2-ethylhexyl phthalate exudes from the container wall and dissolves into the blood (The Japanese Journal of Medical Instrumentation, 54 , 221 (1984)). It has been reported that this di-2-ethylhexyl phthalate hinders the aggregating ability of platelets (Journal of Japan Society of Blood Transfusion, 28(3) 282 (1981)). When the preserving container made of such flexible vinyl chloride resin as described above is used to preserve blood, for example, there is the possibility that the di-2-ethylhexyl phthalate will enter the patient's blood vessels as entrained by the preserved blood during the course of transfusion. This possibility poses a problem from the standpoint of the adverse effect exerted by this compound upon the function of platelets. For the solution of this problem, the feasibility of the use of a material not containing this di-2-ethylhexyl phthalate has been studied. It has been learnt that when blood is preserved in containers made of materials not containing di-2-ethylhexyl phthalate, the erythrocytes in the preserved blood are hemolyzed during the course of preservation. A search of the cause for this hemolysis has revealed that di-2-ethylhexyl phthalate is effective in hindering hemolysis (Blood, 646 1270-(1984)). In other words, when blood is preserved in a blood container made of the conventional flexible vinyl chloride resin which incorporates therein di-ethylhexyl phthalate as a plasticizer, the di-2-ethylhexyl phthalate dissolving into the preserved blood serves to hinder the hemolysis of erythrocytes. As a measure against such an adverse phenomenon as described above, a contradictory method which comprises preserving blood in a container made of a material incapable of exuding an incorporated plasticizer (or a material not containing any plasticizer) and , prior to actual use of the preserved blood, adding di-2-ethylhexyl phthalate to the blood thereby preventing the blood from hemolysis has been proposed (U.S. Patent No. 6,326,025). The idea of using di-2-ethylhexyl phthalate as a hemolysis depressant, however, is undesirable from the standpoint of physiological safety. Further, the blood bag containing the blood extracted from a donor is generally forwarded to a hospital, as accompanied by a blood collection tube containing the same blood as that in the blood bag so that the blood in the tube may be used as a sample for testing the blood for adaptability to the patient's blood in advance of the transfusion. As the time of storage of this blood bag increases to approach the 21st day of extraction fixed officially (in Japan) for the availability of concentrated red cells, the blood contained in the blood collection tube yields to hemolysis in much the same way as described above. The hemoglobin liberated in consequence of the hemolysis brings about adverse effects on the results of various measurements performed for clinical test and interferes with the tests. This fact has posed a problem. As clearly gathered from the observations illustrated above, the desirability of developing a material capable of producing a notable protective action for erythrocytes has found enthusiastic recognition in various fields including the medical field. At present, flexible vinyl chloride resins are widely used not only in medical appliances but also in food containers on account of their desirability in terms of moldability, flexibility, transparency, resistance to heat, and cost. For their feasibility in such food containers, the question of toxicity matters much. For this reason, the soft vinyl chloride resins used in the food containers generally incorporate therein as a plasticizer di-2-ethylhexyl phthalate which is accepted as a relatively safe compound in all the known plasticizers. Incidentally, di-2-ethylhexyl phthalate has been demonstrated to possess a high migrating property and mono-2-ethylhexyl phthalate (MEHP), a metabolite of di-2-ethylhexyl phthalate, to possess mutagenicity [Yagi et al., Teratology, 14 , 259 (1976)]. In view of the defective properties exhibited as described above by the conventional plasticizers coupled with the poor abilities manifested thereby in the control of the phenomenon of coagulation of blood platelets, the desirability of perfecting a safe substance capable of taking the place of di-2-ethylhexyl phthalate as a plasticizer has been finding enthusiastic recognition. An object of this invention, therefore, is to provide a novel plasticizer. A further object of this invention is to provide vinyl chloride type resin compositions for medical appliances and medical implements which make use of the novel plasticizer. From another aspect, the present invention relates to the use of a triglyceride compound as a plasticizer which exhibits no toxicity and possesses highly desirable compatibility and plasticizing efficiency relative to vinyl chloride type resins. Another object of this invention is to provide vinyl chloride type resin compositions for medical appliances and medical implements which exhibit high physiological safety. Still another object of this invention is to provide vinyl chloride type resin compositions for medical appliances and medical implements which possess thermal stability enough to withstand sterilization in an autoclave and high transparency, flexibility, and processibility. Disclosure of the Invention: The various objects described above are accomplished by a triglyceride compound used as a plasticizer for vinyl chloride type resins, which is represented by the general formula (I'): wherein R⁴, R⁵, and R⁶ are independently an aliphatic hydrocarbon group of 1 to 11 carbon atoms. This invention further discloses a triglyceride compound used as plasticizer for vinyl chloride type resins, wherein R⁴, R⁵, and R⁶ in the general formula (I') are independently an aliphatic hydrocarbon group of 5 to 9 carbon atoms. This invention also discloses a triglyceride compound used as plasticizer for vinyl chloride type resins wherein at least one of the substituents, R⁴, R⁵, and R⁶, in the general formula (I') possesses a branched structure. Further, this invention discloses a plasticizer for vinyl chloride type resins, wherein the triglyceride compound is glyceryl tri-2-ethylhexanoate. This invention also discloses a triglyceride compound used as plasticizer for vinyl chloride type resins, wherein the plasticizer is incorporated in a proportion falling in the range of 5 to 40% by weight. The various objects described above are further accomplished by a vinyl chloride type resin composition for medical appliances, which is characterized by having incorporated in a vinyl chloride type resin a plasticizer comprising a triglyceride compound represented by the general formula (I'). This invention further discloses a vinyl chloride type resin composition for medical appliances, wherein the triglyceride represented by the general formula (I') is incorporated in a proportion falling in the range of 5 to 40% by weight. This invention also discloses a vinyl chloride type resin composition for medical appliances, wherein 5 to 60 parts by weight of the triglyceride compound represented by the general formula (I'), 2 to 8% by weight of an epoxidized vegetable oil, and 0.03 to 2% by weight of a stabilizer are incorporated. The various objects described above are further accomplished by a medical implement, which is characterized by being substantially formed with a vinyl chloride type resin composition having incorporated in a vinyl chloride type resin a plasticizer comprising a triglyceride compound represented by the general formula (I'). This invention also discloses a medical implement, which is capable of withstanding sterilization in an autoclave. This invention further discloses a medical implement which is a container for storing blood. Brief Description of the Drawing: Fig. 1 is a front view illustrating a blood bag as a typical medical implement formed substantially of a vinyl chloride type resin composition for medical appliances incorporating therein a plasticizer as an embodiment of the present invention. Best Mode for Carrying Out the Invention: The triglyceride compound used as plasticizer of the present invention is a triglyceride compound represented by the general formula (I'). Such glycerine esters of medium chain-length fatty acid as triglyceride compounds represented by the general formula (I') are safe substances of low toxicity as compared with di-2-ethylhexyl phthalate heretofore used as a plasticizer. It is surprising to note that the triglyceride compounds represented by the general formula (I') excel in compatibility with vinyl chloride type resins and manifest ample plasticizing efficiency therefor. The vinyl chloride type resin composition of the present invention which incorporates a triglyceride compound represented by the general formula (I') as a plasticizer, therefore, proves to be a material suitable for medical implements. The shaped articles obtained by molding this material are excellent in safety, processibility, flexibility, transparency, and resistance to heat. when these shaped articles are used as medical implements, they can manifest their inherent effects to the fullest extent. These effects are particularly conspicuous when these medical implements are destined to contact blood or other body fluids. Now, the present invention will be described more specifically below with reference to working examples. To facilitate comprehension of this invention, the paragraphs titled "Plasticizer," "Medical Implement Formed with Vinyl Chloride Type Resin composition for Medical Appliances Incorporating the Palsticizer," and "Example," will be covered in the following part of the text. Plasticizer The triglyceride compound used as plasticizer of the present invention is represented by the general formula (I'). In the general formula (I') representing the triglyceride compounds of the present invention, the total number of the carbon atoms in the aliphatic hydrocarbon groups, R⁴, R⁵, and R⁶, is limited to the range of 1 to 11. This is because the triglyceride compound loses its compatibility with the vinyl chloride resin if the total number of the carbon atoms deviates from the range of 1 to 11. When the total number of the carbon atoms in the aliphatic hydrocarbon groups, R⁴, R⁵, and R⁶, is limited to the narrower range of 5 to 9, there ensues a desirable effect that the plasticizing efficiency of the triglyceride compound for the vinyl chloride resin is enhanced. In the triglyceride compound represented by the general formula (I'), it is more desirable from the standpoint of the compatibility with the vinyl chloride resin for the aliphatic hydrocarbon groups, R⁴, R⁵, and R⁶, each to possess a branched structure. In the triglyceride compound represented by the general formula (I'), all the aliphatic hydrocarbon groups, R⁴, R⁵, and R⁶, are not required to be identical with one another. They may be a combination of aliphatic hydrocarbon groups differing in chain length from one another. Further, the aliphatic hydrocarbon groups, R⁴, R⁵, and R⁶, may be either saturated aliphatic hydrocarbon groups or unsaturated aliphatic hydrocarbon groups. To be concrete, the triglyceride compounds represented by the generalformula (I') are glyceryl triacetate (triacetin), glyceryl tripropionate (tripropionin), glyceryl tributyrate (tributyrin), glyceryl triisobutyrate (triisobutyrin), glyceryl trivalerate (trivalerin), glyceryl tricaproate, glyceryl tricaproate, glyceryl tricaprilate, and glyceryl trilaurate (trilaurin). Among other triglyceride compounds enumerated above, glyceryl tricaproate, glyceryl tricaprilate, glyceryl tri-2-ethylhexanoate, and glyceryl tricaprate prove to be particularly desirable. The best of all these triglyceride compounds is glyceryl tri-2-ethylhexanoate. The vinyl chloride type resins which can be plasticized by the plasticizer comprising the triglyceride compound represented by the general formula (I') according with the present invention include various vinyl chloride type copolymers described fully later on in addition to the homopolymer of vinyl chloride. The triglyceride compounds represented by the general foumula (I') invariably possess ample compatibility and plasticizing efficiency for such vinyl chloride type resins as described above and , therefore, can be used each as a plasticizer. In this case, the amount of the triglyceride compound to be incorporated as a placticizer is in the range of 5 to 40% by weight, preferably 10 to 35% by weight. The vinyl chloride type resin compositions which have been plasticized exclusively with a triglyceride compound represented by the general formula (I') according with the present invention possess highly desirable safety. Where this vinyl chloride type resin composition dictates perfect absence of toxicity, it is desired to comprise 5 to 40% by weight of a triglyceride compound represented by the general formula (I'), 2 to 8% by weight of an epoxidized vegetable oil such as epoxidized soybean oil or epoxidized linseed oil as a combination stabilizer and auxiliary plasticizer, and 0.03 to 2% by weight of a metallic soap of calcium or zinc salt of stearic acid, laurylic acid, ricinolic acid, or naphthenic acid as a stabilizer. The triglyceride compound used as a plasticizer of the present invention for vinyl chloride type resins is capable of acting as a plasticizer by itself for vinyl chloride type resins as described above. Optionally, it may be used in combination with other plasticizers. As such other plasticizer which can be used in combination with the plasticizer of the present invention, any of the conventional plasticizers available for vinyl chloride resins can be used. Examples of the conventional plasticizers useful in this case include phthalic esters such as dibutyl phthalate (DBP), dihexyl phthalate (DHP), di-2-ethylhexyl phthalate (DOP), di-n-octyl phthalate (DnOp), diisooctyl phthalate (DIOP), diheptyl phthalate, didecyl phthalate (DDP), diisodecyl phthalate (DIDP), octyl decyl phthalate, and butyl benzyl phthalate (BBP), trimellitic esters such as tributyl trimellitate and trioctyl trimellitate, aliphatic polybasic esters such as dioctyl adipate (DOA), dioctyl azelate (DOZ), and dioctyl sebacate (DOS), phosphoric esters such as tricresyl phosphate (TCP), trixylenyl phosphate (TXP), monooctyl diphenyl phosphate (Santicizer 141), monobutyl xylenyl phosphate (B-2-X), and trioctyl phosphate (TOF), citric esters such as tributyl acetyl citrate, trioctyl acetyl citrate, and tributyl citrate, and butyl phthalyl butyl glycolate (BPBG). Vinyl Chloride Type Resin Composition for Medical Appliances Incorporating Plasticizer The flexible vinyl chloride type resin composition for medical appliances according with the present invention is obtained by having incorporated in a vinyl chloride type resin the plasticizer comprising a triglyceride compound represented by the general formula (I'). Since the vinyl chloride type resin composition of the present invention incorporates therein as a plasticizer thereof the triglyceride compound represented by the general formula (I') which has no toxicity, excels in compatibility with the vinyl chloride type resins, and exhibits ample plasticizing efficiency, it is suitable as a material for medical implements. The shaped articles obtained by molding this material is highly excellent in safety, processibility, flexibility, transparency, and resistance to heat. When they are used as medical implements, therefore, they can manifest their inherent effects to the fullest extent. These effects are manifested particularly conspicuously when the medical implements are destined to contact blood or other body fluids. The vinyl chloride type resins which are usable for the production of the vinyl chloride type resin composition for medical appliances according with the present invention include polyvinylidene chloride, copolymers between not less than 40% by weight, more desirably not less than 65% by weight, and most desirable not less than 75% by weight, of vinyl chloride and other copolymerizable monomer, besides homopolymer of vinyl chloride. The average polymerization degree of the vinyl chloride resin is in the range of 400 to 3,000, more desirably 600 to 2,700, and most desirably 800 to 1,700. Examples of the comonomer usable in combination with the vinyl chloride in the production of the copolymer include vinylidene chloride, ethylene, propylene, vinyl acetate, vinyl bromide, vinyl fluoride, styrene, vinyl toluene, vinyl acetate, vinyl bromide, vinyl fluoride, styrene, vinyl toluene, vinyl pyridine, acrylic acid, alkyl acrylates (such as methyl acrylate, ethyl acrylate, isopropyl acrylate, n-butyl acrylate, and 2-ethylhexyl acrylate), methacrylic acid, alkyl methacrylates (such as methyl methacrylate, ethyl methacrylate, and 2-ethylhexyl methacrylate), acrylonitrile, and methacrylonitrile. Optionally, the vinyl chloride resin may incorporate therein styrene-acrylonitrile copolymer or styrene-methacrylonitrile copolymer. In the vinyl chloride type resin of this kind, the triglyceride compound represented by the general formula (I') is incorporated. The triglyceride compound represented by the general formula (I') is incorporated in a proportion falling in the range of 5 to 40% by weight, preferably 10 to 35% by weight. Optionally, the vinyl chloride type resin composition for medical appliances according with the present invention may incorporate therein an epoxidized vegetable oil such as epoxidized soybean oil or epoxidized linseed oil which is useful as a combination stabilizer and auxiliary plasticizer, a methallic soap of calcium or zinc and stearic acid, laurylic acid, ricinolic acid, or naphthenic acid which is useful as a stabilizer, a lubricant, or an antioxidant. The amount of the epoxidized vegetable oil to be incorporated as a combination stabilizer and auxiliary plasticizer is in the range of 2 to 8% by weight, preferably 4 to 6% by weight. The amount of the metallic soap to be incorporated as a stabilizer is in the range of 0.03 to 2% by weight, preferably 0.05 to 1% by weight. The molding of the vinyl chloride type resin composition for medical appliances according with the present invention can be effected by any of the conventional methods available for vinyl chloride type resin compositions. Examples include calender molding, extrusion molding, and plastisol method. The adhesion of molded parts may be attained by high-frequency fusion or thermal fusion. Medical Implements Formed with Vinyl Chloride Type Resin Composition for Medical Appliances Incorporating plasticizer The medical implements of the present invention are formed substantially with the vinyl chloride type resin composition having incorporated in a vinyl chloride type resin a plasticizer comprising a triglyceride compound represented by the general formula (I') and possess highly desirable physical properties in terms of safety, processibility, flexibility, transparency, and resistance to heat. The medical implements of the present invention embrace body fluid preserving containers such as blood bags, medical devices such as catheters, transfusion sets, and blood circuits, packages for the aforementioned medical devices, and packages for medicines such as tablets. Now, a blood bag as a typical medical implement embodying the present invention will be described below with reference to the accompanying drawings. Fig. 1 depicts a blood bag connected to a blood collection needle. A blood bag 52 made of the aforementioned vinyl chloride type resin composition and provided with an outlet 51 fitted with a plurality of peel tabs has a peripheral part 53 thereof heat sealed as by high-frequency heating or other similar heating means. A tube 55 made of the aforementioned vinyl chloride resin composition and adapted to communicate with an inner space 54 of the blood bag 52 is connected to the blood bag 52 . The tube 55 is provided at the leading end thereof with a needle base 56, to which a piercing needle 57 is fitted. This piercing needle is protected with a cap 58. The medical implement of this invention has been described as embodied in a blood bag. Other body fluid preserving containers, medical devices such as catheters, transfusion sets, and blood circuits, packages for such medical devices as mentioned above, and package for medicines such as tablets are formed similarly conveniently with the vinyl chloride type resin composition incorporating therein the plasticizer comprising a triglyceride compound represented by the general formula (I'). The medical implements of the present invention are sterilized before they are put to use. This sterilization is effected chemically with ethylene oxide or physically with an autoclave, for example. Preferably, they are sterilized by autoclaving. In the sterilization by use of an autoclave, medical implements are generally treated at about 121°C for about 60 minutes. As described above, the medical implements of the present invention possess thermal stability enough to withstand these harsh conditions of the treatment of autoclaving. Example Now, for the purpose of facilitating the comprehension of this invention, working examples will be cited below. These examples are intended purely as illustrations of the invention and are not meant to limit the scope of this invention in any respect. Example 1 A flexible vinyl chloride resin composition using components as shown in Table 1 was roll kneaded at 160°C for 10 minutes and then molded in the form of a sheet 0.4 mm in thickness with an extruding machine. A miniature blood bag having an inner volume of 20 ml was produced by superposing two such sheets and sealing the superposed sheets by fusing prescribed portions thereof by high-frequency heating. About 20 ml of the CRC adjusted in advance to a hematocrit value of about 70% was placed in the bag and left standing at rest at 4°C for 4 weeks. After the standing, the CRC was tested for plasma hemoglobin concentration by the TMB method (Clin.Chem., 23 , 749, 1977). The results were as shown in Table 2. Controls 1 and 2 Miniature blood bags were produced by following the procedure of Example 1, excepting flexible vinyl chloride resin compositions using the same components in different proportions indicated in Table 1 were used instead. The CRC's were left standing at rest in the blood bags and, at the end of the standing, tested for plasma hemoglobin concentration. The results were as shown in Table 2. Composition (parts by weight) Example 1 Control 1 Control 2 Polyvinyl chloride (average polymerization degree, P=1,300) 100 100 100 Di-2-ethylhexyl phthalate - 50 - Di-normal decyl phthalate 37 - 50 Glyceryl tri-2-ethylhexanoate 15 - - Epoxidized soybean oil 8 8 8 Ca/Zn type stabilizer 0.1 0.1 0.1 Plasma hemoglobin concentration (mg/dl) Example 1 47 Control 1 46 Control 2 133 It is clearly noted from the results given above that the CRC preserved in the blood bag formed of the flexible vinyl chloride resin composition incorporating therein the hemolysis depressant of this invention, i.e. glyceryl tri-2-ethylhexanoate (Example 1) was found to possess a plasma hemoglobin concentration substantially equal to the plasma hemoglobin concentration of the CRC preserved in the blood bag formed of the flexible vinyl chloride resin composition incorporating di-2-ethylhexyl phthalate (Control 1), indicating that it exhibited a highly desirable protective action for erythrocytes. In the CRC of Control 1, the amount of di-2-ethylhexyl phthalate exuded from the blood bag was 250 ppm, whereas the amount of glyceryl tri-2-ethylhexanoate exuded into the CRC of Example 1 was 46 ppm and that of di-normal decyl phthalate was 1 ppm. Example 2 A vinyl chloride type resin composition made up of the components as indicated in Table 3 was roll kneaded at 150°C for 5 minutes as indicated in Table 3 was roll kneaded at 150°C for 5 minutes and press molded at 160°C under 400 kg/cm for 6 minutes to produce a sheet 0.4 mm in thickness. The sheet was tested for physical properties. The results were as shown in Table 4. The test for 100% modulus and that for tensile strength were carried out by the methods defined in JIS K7113. When this sheet was sterilized in an autoclave at 121°C for 60 minutes, it was found to sustain absolutely no deformation. Control 3 A sheet 0.4 mm in thickness was produced by following the procedure of Example 2, except that a vinyl chloride type resin composition made up of the components as shown in Table 3 was used instead. The sheet was tested for physical properties. The results were as shown in Table 4. Formulation of vinyl chloride type resin composition Component Example 2 Control 3 Vinyl chloride (average polymerization degree, P = 1,300) 100 100 Glyceryl tri-2-ethylhexanoate 50 - Di-2-ethylhexyl phthalate - 50 Epoxidized soybean oil 10 10 Stabilizer 1 1 Properties of vinyl chloride type resin composition Example 2 Control 3 100% modulus (kgf/cm²) 112 100 Tensile strength (kgf/cm²) 204 206 It is clearly noted from Table 4 that glyceryl tri-2-ethylhexnoate, a plasticizer according with the present invention manifested as highly desirable compatibility and plasticizing efficiency relative to vinyl chloride resin as 2-ethylhexyl phthalate and the vinyl chloride type resin composition plasticized with this glyceryl tri-2-ethylhexanoate possessed physical properties equal to those of the conventional vinyl chloride type resin composition. Industrial Appicability: The plasticizer according with the present invention is substantially non-toxic and exhibits highly desirable compatibility and plasticizing efficiency relative to vinyl chloride type resins. Since the vinyl chloride type resin compositions obtained by incorporating the plasticizer are consequently capable of manifesting outstanding physical properties in terms of safety, moldability, flexibility, transparency, and thermal stability, they contribute greatly to numerous fields, especially in applications to medical appliances and food packages.

Claims: Use of a triglyceride compound represented by the general formula (I') : wherein R⁴, R⁵ and R⁶ are independently an aliphatic hydrocarbon group of 1 to 11 carbon atoms as a plasticizer for vinyl chloride-type resins. Use according to claim 1, wherein R⁴, R⁵ and R⁶ in said general formula (I') are independently an aliphatic hydrocarbon group of 5 to 9 carbon atoms. Use according to claim 1, wherein at least one of the substituents, R⁴, R⁵ and R⁶ in said general formula (I') possesses a branched structure. Use according to claim 3, wherein said triglyceride compound represented by said general formula (I') is glyceryl tri-2-ethylhexanoate. Use according to one of claims 2 to 4, wherein said triglyceride compound of formula (I') is incorporated in a vinyl/chloride-type resin composition in an amount in the range of 5 to 40% by weight. A vinyl chloride-type resin composition for medical appliances, characterized in that the vinyl chloride type resin contains a triglyceride compound of formula (I') as defined in anyone of claims 1 to 5. A vinyl chloride type resin composition according to claim 6 , wherein said triglyceride compound represented by said general formula (I') is incorporated in an amount in the range of 5 to 40 % by weight, an epoxidized vegetable oil in an amount in the range of 2 to 8 % by weight, and a stabilizer in an amount in the range of 0.03 to 2 % by weight. A medical implement characterized by comprising a vinyl chloride resin composition for medical appliances, said vinyl chloride resin composition being as defined in anyone of claims 6 and 7. A medical implement according to claim 8 which is a container for blood. A medical implement according to claim 8 which is capable of withstanding the conditions of sterilization in an autoclave.

Inventors: KIMURA, AKIO, KUBOTA, YOSHINORI, NAGAI, HIROFUMI, TAMURA, YOUKO
Applicants: KAO CORPORATION, TERUMO KABUSHIKI KAISHA
Application year: 1988
Main classification: A61L31
IPC codes: A61L31, A61J1, A61L33, C08K5