ANTI-INFLAMMATORY AGENTS

Abstract: This invention provides benzene derivatives of the Formula I pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.

Description: This invention relates to novel leukotriene antagonists. The present leukotriene antagonists possess an unusual 2,4,5-substitution pattern (versus the stan­ dard 2,3,4 pattern) on the phenolic ring. The present antagonist compounds are not only effective as antago­ nists of the SRS-A leukotrienes (LTC₄, LTD₄, and LTE) but also leukotriene LTB₄. LTB₄ has been indicated as a causitive agent in inflammatory diseases such as psoriasis and inflammatory bowel disease. Research in the area of allergic reactions of the lung has provided evidence that arachidonic acid derivatives formed by the action of lipoxygenases are related to various disease states. Some of these arachidonic acid metabolites have been classified as members of a family of eicosatetraenoic acids termed leukotrienes. Three of these substances (i.e., leuko­ triene C₄, D₄ and E₄) are currently thought to be major components of what has been previously called slow reacting substance of anaphylaxis (SRS-A). Leukotriene B₄ (LTB₄) is a proinflammatory lipid which has been implicated in the pathogenesis of psoriasis, arthritis, chronic lung diseases, inflam­ matory bowel diseases, and other inflammatory states characterized by the infiltration and aggregation of polymorphonuclear leukocytes. Thus aggregated, the polymorphonuclear leukocytes liberate tissue-degrading enzymes and reactive chemicals causing the inflammation. Antagonism of LTB₄ should therefore provide a novel therapeutic approach to treatment of these conditions. There are many compounds that antagonize the effects of the sufidopeptidoleukotriene LTC₄, LTD₄ and LTE₄. See, for example, Marshall et al ., U.S. Patent No. 4,661,505, and R. D. Dillard, European Patent Application No. 132,366. The compounds of these references, as well as the many other compounds in this field, are limited to or clearly prefer a 2,3,4-substitution pattern on the phenol ring. In fact, substitution on the 5-position of the phenol ring was thought to greatly diminish or eliminate the LTD₄ antagonist activity of the compounds. Much to our surprise, we have found that the present 2,4,5-substituted phenolic compounds not only LTD₄ antagonists, but a good many of the claimed compounds are also LTB₄ antagonists. LTB₄ is an important causi­ tive agent in chronic inflammatory disease such as psoriasis and inflammatory bowel disease (IBD). Adequate therapy presently does not exist for either psoriasis or IBD. Accordingly, the novel 2,4,5-substituted phenolic leukotriene antagonists of the present inven­ tion can be used in the treatment of inflammation. Also, most of the compounds are LTB₄ antagonists and should therefore also be useful in the treatment of conditions such as psoriasis, inflammatory bowel disease, and allergic disorders such as asthma, where leukotri­ enes are thought to be causal mediators. Specifically, this invention provides compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R₁ is hydrogen or R′OOC-; Z is -(CH₂) n - or phenylene; n is 1-8; R₂ is hydroxy, halo, or -O-(CH₂) m -Y; R₃ is C₁-C₆ alkyl, C₁-C₆ alkanoyl, C₂-C₄ alkenyl, C₁-C₄ alkoxy, hydroxy-substituted C₁-C₃ alkyl, or -CH₂-D; A is a bond or straight or branched chain C₁-C₁₀ alkylidene; R₄ is C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, 1,2,4-triazol-1-yl, hydroxy, -CN, halo, -N₃, -NR₅R₆, -COR₇, -S(O) p -(C₁-C₄ alkyl), 5-tetrazolyl optionally substituted with a C₁-C₄ alkyl group or -(CH₂) q -COOR′, or phenyl optionally substituted with one or two groups selected from halo, cyano, C₁-C₃ alkyl, trifluoromethyl, -CH₂CN, -CH₂Br, C₁-C₄ alkoxy, -S(O) p -(C₁-C₄ alkyl), acetenyl, -COOR′, 5-tetrazolyl, or 5-tetrazolyl substituted with C₁-C₄ alkyl or -(CH₂) q -COOR′; where each R′ is independently hydrogen or C₁-C₄ alkyl; m is 1-4; q is 1-4; Y is hydrogen or -CN; D is halo, C₁-C₄ alkoxy, or -S-(C₁-C₄ alkyl); R₅ and R₆ are independently hydrogen, C₁-C₃ alkyl or C₂-C₄ alkanoyl, or when taken together with the nitrogen atom to which they are attached form a morpholino ring; R₇ is hydroxy, C₁-C₄ alkoxy, halo, -NR₅R₆, -NHOH, or C₁-C₃ alkyl; and each p is 0, 1, or 2, provided that when A is a bond, R₄ must be C₁-C₆ alkyl or an optionally substituted phenyl group, and further provided that when one of R₅ and R₆ is C₂-C₄ alkanoyl, the other of R₅ and R₆ is hydrogen. A second aspect of this invention is a phar­ maceutical formulation which comprises as an active ingredient a compound of Formula I as defined above, or a pharmaceutically acceptable salt thereof, associated with one or more pharmaceutically acceptable carrier or excipients therefor. A preferred group of compounds are the com­ pounds of Formula Ia: and pharmaceutically acceptable salts thereof, wherein R₁′ is methyl or ethyl; R₂′ is hydrogen or methyl; R₃′ is ethyl, propyl, -CH₂-S-CH₃, or allyl; and R₄′ is hydroxy, cyano, -COOR′, -CONR₅R₆, -CO(C₁-C₃ alkyl), -S(O) p -(C₁-C₄ alkyl), 5-tetrazolyl optionally substituted with a C₁-C₄ alkyl group, or phenyl optionally substituted in the meta position with one of the groups listed above, particularly cyano. The following definitions refer to the various terms used throughout this disclosure. The term "C₁-C₆ alkyl" refers to the straight and branched aliphatic radicals of 1 to 6 carbon atoms, such as methyl, ethyl, propyl, isopropyl, butyl, tert-­ butyl, sec-butyl, isobutyl, pentyl, hexyl, and the like. Within this term are included the terms "C₁-C₃ alkyl" and "C₁-C₄ alkyl". The term "C₁-C₄ alkoxy" refers to methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, isobutoxy, and tert-butoxy. The term "C₁-C₄ alkoxy" includes within its definition the term "C₁-C₃ alkoxy". The term "halo" refers to fluoro, chloro, bromo, and iodo. The term "C₂-C₆ alkenyl" refers to groups such as vinyl, allyl, butenyl, hexenyl, and the like. The term "C₂-C₆ alkynyl" refers to groups such as acetenyl, propargyl, butynyl, hexynyl, and the like. The term "C₁-C₆ alkanoyl" refers to the straight and branched aliphatic acyl radicals of 1 to 6 carbon atoms such as formyl, acetyl, propionyl, butyryl, 2-methyl­ propionyl, pentanoyl, hexanoyl, and the like. The terms "C₁-C₁₀ alkylidene" and "phenylene" are divalent radicals derived from a C₁-C₁₀ alkane or benzene, respectively. When any of the substituents in Formula I are carboxylic acid or 5-tetrazolyl moieties, the compounds of this invention include the pharmaceutically acceptable base addition salts thereof. Such salts include those derived from inorganic bases, such as ammonium and alkali and alkaline earth metal hydroxides, carbonates, bicarbonates, and the like, as well as salts derived from basic organic amines, such as aliphatic and aromatic amines, aliphatic diamines, hydroxy alkylamines, and the like. Such bases useful in preparing the salts of this invention thus include ammonium hydroxide, potassium carbonate, sodium bicarbonate, calcium hydroxide, methyl amine, diethyl amine, ethylene diamine, cyclohexylamine, ethanolamine, and the like. The potassium and sodium salt forms are particularly preferred. It is recognized that when any of the alkyl groups are branched, various stereoisomeric products may exist. This invention is not limited to any particular stereoisomer but includes all possible individual isomers and mixtures thereof. The compounds of this invention may be pre­ pared according to standard methods known in the art. Thus, a further aspect of the instant invention consists of the following processes for preparing the compounds of Formula I. For example, final products and inter­ mediates thereto can be prepared by acylating a benzene derivative as summarized in Scheme I: wherein: R 3a is R₃ or hydrogen, and Q is -A-R₄ or hydrogen. According to this scheme, an acid chloride of formula II is reacted with benzene derivative III under Friedel-Crafts acylation conditions to provide the acyl derivative IV. Any of a number of conditions to effect this transformation are known in the art and are operable. A preferred set of conditions comprises the reaction of II and III with a Lewis acid such as aluminum chloride in the presence of a non-reactive solvent, preferably dichloromethane. The reaction is best carried out at temperatures from about 0 to about 25°C and is generally complete within 2-4 hours. Alternatively, an acid anhydride or other acid halide may be employed in place of acid chloride III. When R 3a is hydrogen, diacylated compounds can be obtained. If two different acyl moieties are desired, such acylations can be performed sequentially. Typically, the acylation is effected using an acylating agent of formula R₁-Z-CO-LG where LG is a leaving group such as chloro, bromo or iodo or a group forming an acid anhydride. When Q is hydrogen, the phenol, either before or after acylation, can be alkylated by standard methods. The phenol is alkylated under typical bimolecular nucleo­ philic substitution ("S N 2") conditions - polar, aprotic solvents, (such as ketones (acetone, methylethyl ketone); amides (dimethylformamide), hexamethylphosphoramide, acetonitrile, and dimethylsulfoxide); preferably with an alkylating agent of the formula X-A-R₄ wherein X is a good leaving group-such as a halo atom (chloro, bromo, iodo) (i.e., the Williamson synthesis); a sulfonate ester group (p-toluene-sulfonate, methyl­ sulfonate, trifluoromethanesulfonate); a sulfonium group (dimethylsulfonium) and the like. It is preferred that the alkylation be carried out in the presence of non-­ nucleophilic bases with a pKa sufficient to deprotonate the hydroxy group of the phenol, same as sodium hydride. It is further preferred that any other reactive function­ ality on the alkylating reagent, such as a carboxylic acid or a tetrazole group, be first protected - such as by converting the carboxy group to a corresponding ester group. Also, newer alkylating reactions, such as using the methyl, ethyl or di-isopropyl azodicarboxylates and an alkyl- or arylphosphine to utilize the coupling of the phenol with an alkanol of the formula HO-A-R₄ in an aromatic hydrocarbon or ethereal solvent. A simi­ lar process is described in U.S. Patent No. 4,604,386. A similar process is used to introduce the -(CH₂) m -Y functionality at the R₂ position when R₂ is hydroxy. Derivatives of Formula IV (or I) which contain an ester or nitrile functionality can be transformed to the corresponding acid and/or tetrazole compounds of the invention according to standard methods. For example, hydrolysis of esters of may be accomplished by any of a variety of acidic or basic conditions, pref­ erably under aqueous conditions. Two preferred methods involve the use of lithium hydroxide in a solvent mixture of acetone/water or potassium hydroxide in a mixture of methanol/water. Under the former conditions, hydrolysis is generally complete in about 12-18 hours at temperatures from about 20-30°C whereas the latter reaction is usually complete in one hour at 20-30°C. Similarly, transformation of the nitriles of this invention to the corresponding tetrazoles can be accomplished by any of a variety of standard methods. Generally, the nitrile is reacted with an azide reagent in a non-reactive solvent. Preferred conditions include the use of ammonium azide in dimethylformamide or tri­ (n-butyl)stannylazide in a non-reactive solvent such as dimethoxyethane or tetrahydrofuran. Under the latter conditions, the reaction is generally heated at or near the reflux temperature of the reaction mixture. The transformation is generally complete under these condi­ tions in 2-3 days. It is generally preferred, in compounds con­ taining both a nitrile and an ester functionality, that the nitrile group be transformed into a tetrazole before hydrolysis of the ester. When A-R₄ or -(CH₂) m -Y are methyl, the corre­ sponding phenols may be obtained via standard demethyla­ tion procedures. Standard methods for this trans­ formation include the use of hydrobromic acid in acetic acid or treatment with molten pyridine hydrochloride. These methods usually also transform a carboxylic acid ester to the corresponding free carboxylic acid. Other intraconversions of compounds are readily apparent to skilled artisans. For example, when R₄ is halo, compounds treated with cyanide, such as potassium or sodium cyanide, in a non-reactive solvent such as dimethylformamide, are transformed into cognates wherein R₄ is -CN. The use of a catalytic amount of iodide is employed to speed the reaction. Such nitriles can be converted into tetrazoles as described above, or hydrolyzed in the presence of a base, such as sodium or potassium hydroxides, in alcoholic water to provide the corresponding carboxylic acids. An alternate process for converting halides into nitriles involves the displacement by carbon anions in sodium amide and liquid ammonia as described in Example 68 which follows. In other intraconversions, the halide deriv­ ative of Formula I (R₄ is halo) is allowed to react with an azide (e.q., sodium azide) amine (e.q., R₅R₆NH), or thiol (e.g., (C₁-C₄ alkyl)-SH), to provide the analogous compounds wherein R₄ is -N₃, -NR₅R₆, and -S-(C₁-C₄ alkyl), respectively. The appropriate reagent is usually employed in the presence of a non-reactive solvent, such as dimethylformamide, and the transfor­ mation is generally complete within about 12-18 hours when kept at approximately 25°C. When a thiol reagent is used, a strong base, such as sodium hydride, is preferably also added. The primary amine compounds (e.g., R₄ is -NH₂) can also be obtained by reducing the corresponding azide, e.g., through catalytic hydro­ genation. The primary amine produced by any of these methods may be acylated by standard means, such as upon treatment with an alkanoyl halide or anhydride in the presence of a non-reactive acid scavenger. Other transformations are also well known. Carboxylic acids can be esterified by standard means, or converted to acid halides which are then reacted with amines of the formula R₅R₆NH to provide the corre­ sponding amides. Similarly, esters, amides, and nitriles may be hydrolyzed to the carboxylic acid by means as described previously. Nitriles can also be hydrolyzed to the primary amide by treatment with aqueous base. Alkylation of tetrazoles, such as with a C₁-C₄ alkyl halide X-(CH₂) q -COOR′, in the presence of an acid scavenger, such as potassium carbonate, and an inert solvent such as dimethylformamide, provides both 1- and 2-substituted tetrazol-5-yl derivatives which may be separated by standard methods, for example, by employing high pressure liquid chromatography. Although many of the compounds wherein R₄ is hydroxy can be made directly via alkylation of the desired phenol with a halo alkanol, some carbinols may also be obtained by reducing the corresponding ester or ketone, or by alkylating an acid halide derivative as found in Examples 102 and 103 which follow. Similar transformations may be made with substituents on the optionally substituted phenyl ring of the R₄ moiety, and also various substituents accorded to R₃. For example, when R₃ is alkenyl, the double bond can be oxidized with a peracid to the corresponding epoxide intermediate which, upon catalytic hydrogenation, can be transformed into a hydroxyalkyl derivative. Reduction of an alkanoyl derivative also provides a carbinol analog. Hydrogenation of an alkene derivative or further reduction of the carbinol provides the alkyl substituted compound. In the special case of a benzal­ dehyde being transformed into a methanol, treatment of the methanol with lithium chloride and collidine in dimethylformamide provides the versatile chloromethyl derivative which, upon treatment with an alkanethiol or methanol/silver perchlorate, serves as an intermediate to the alkylthiomethyl and methoxymethyl compounds of this invention, respectively. The thio derivatives and intermediates of this invention (p is 0) may be transformed into the corre­ sponding sulfoxide (p is 1) compounds upon treatment with a mild oxidizing agent, such as hydrogen peroxide in methanol, meta-chloroperbenzoic acid (MCPBA) in methylene chloride at 0°C., or an alkali metal periodate in aqueous alcohol. The corresponding sulfones (p is 2) are prepared from the thio or sulfoxide compounds on treatment with a strong oxidizing agent such as hydrogen peroxide in acetic acid or m-chloroperbenzoic acid in methylene chloride at 20-30°C. In addition, various compounds of Formula I can be prepared from other compounds, precursors, or intermediates of Formula I by standard methods such as hydrolysis, esterification, alkylation, oxidation, reduction, and the like, as are well known to those skilled in the art. A preferred process of the present invention is set forth in Scheme II: In the above Scheme II, diphenol V is alkylated employing an approximately 1:1 stoichiometry with 1,5-­ dibromopentane to the hydroxyacetophenone VI. The hydroxyacetophenone is in turn reacted with sodium 2-cyanopropan-2-ate (formed in situ in a sodium in ammonia mixture) to give the cyano compound VII. The cyano compound is reacted with an azide reagent (such as tri(n-butyl)tin azide) to yield the tetrazole compound VIII. Intermediate compounds II and III and any other necessary reagents are either commercially avail­ able, known in the literature, or can be prepared according to methods known in the art as exemplified by the examples which follow. The following examples further illustrate the preparation of the intermediates and compounds of this invention. The examples are illustrative only and are not intended to limit the scope of the invention in any way. Where structures were confirmed by infra-red, proton nuclear magnetic resonance, or mass spectral analysis, the compound is so designated by "IR", "NMR", or "MS", respectively. Preparation 1 2-allyl-4-acetyl-5-methoxyphenol A. Preparation of 4-allyloxy-2-hydroxyaceto­ phenone. A mixture of 60.8 g of 2,4-dihydroxyaceto­ phenone, 38.0 ml of allyl bromide, 60.7 g of potassium carbonate, 5 g of potassium iodide, and 500 ml of methyl ethyl ketone was heated at reflux for 24 hours. The mixture was filtered and the filtrate concentrated in vacuo . The residue was dissolved in ethyl acetate/­ Skelly B, washed successively with potassium carbonate and sodium chloride solutions, dried over sodium sul­ fate, filtered; and concentrated in vacuo to provide 69.4 g of the subtitle intermediate as an oil which was used without further purification. B. Preparation of 4-allyloxy-2-methoxyaceto­ phenone. To a mixture of 10.6 g of a 50% sodium hydride dispension in oil and 18.7 ml of methyl iodide in 150 ml of dimethylformamide cooled to 0°C. by means of an external ice bath was added a solution of 38.4 g of 4-allyloxy-2-hydroxyacetophenone in 100 ml of dimethyl­ formamide over a 30 minute interval. The mixture was allowed to warm to room temperature and then heated for 5 hours at 50-60°C. After cooling, the reaction mixture was added to ethyl acetate and dilute hydrochloric acid. The layers were separated, and the organic layer was washed with a saturated sodium chloride solution, dried over sodium sulfate, filtered, and concentrated in vacuo . The residue was dissolved in a minimum of hot heptane, and on subsequent cooling to room temperature, 13.63 g of the desired subtitle intermediate were re­ covered, m.p. <25°C. Analysis for C₁₂H₁₄O₃: Calculated: C, 70.23; H, 6.38; Found: C, 70.02; H, 6.56. C. Preparation of 2-allyl-4-acetyl-5-methoxy­ phenol. Under a nitrogen atmosphere, 7.4 g of 4-allyl­ oxy-2-methoxyacetophenone were heated with stirring at 210°C. After cooling, the residue was dissolved in methylene chloride/heptane and cooled overnight in a freezer (ca -20°C). The crystals which formed were recovered by filtration affording 1.78 g of the title intermediate. NMR. Analysis for C₁₂H₁₄O₃: Calculated: C, 69.89; H, 6.84; Found: C, 68.81; H, 6.42. Preparation 2 5-allyl-2,4-dihydroxyacetophenone To 106 mg of 2-allyl-4-acetyl-5-methoxyphenol in 15 ml of methylene chloride at -78°C under a nitrogen atmosphere were added 1.5 ml of a 1.0 M solution of boron tribromide in methylene chloride. The mixture was allowed to warm to -45°C over the next 30 minutes and then added to ethyl acetate and a saturated sodium chloride solution. The layers were separated and the organic layer dried over sodium sulfate, filtered, and concentrated in vacuo . The residue was purified by preparative thin layer chromatography (silica gel) eluting with 40% ethyl acetate in hexane providing 51 mg of the desired title intermediate. Crystallization from diethyl ether/hexane provided material with a melting point of 74-76°C. NMR. Preparation 3 6-(5-Ethyl-2,4-dihydroxyphenyl)-6-oxohexanoic acid, methyl ester To a mixture of 50 ml of a 1M solution of boron tribromide in methylene chloride cooled to 0°C were added 3.08 g of 6-(5-ethyl-2,4-dimethoxyphenyl)-­ 6-oxohexanoic acid, methyl ester (See example 6). While allowing the temperature to warm to room tem­ perature, the mixture was stirred for 24 hours. An additional 25 ml of boron tribromide were added and the mixture was again stirred overnight. The reaction mix­ ture was partitioned between a cold ammonium chloride solution and ethyl acetate. The layers were separated and the organic layer was again washed with cold ammonium chloride solution. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo . The residue was dissolved in 200 ml of methanol. Under a nitrogen atmosphere, two milliliters of sulfuric acid were added, and the mixture heated at reflux for three hours. After removing the methanol in vacuo , the residue was dissolved in ethyl acetate, washed twice with a saturated sodium chloride solution, dried over sodium sulfate, filtered, and concentrated in vacuo . The resulting residue was purified by high pressure liquid chromatography over silica gel eluting with a 0-40% ethyl acetate in hexane gradient. The appropriate fractions were combined and concentrated in vacuo to provide 0.36 g of the desired title intermediate, m.p. = 62-64°C. According to the same procedure (in some cases less the step reforming the ester), the following inter­ mediates were prepared from the corresponding dimethoxy compounds of Examples 1-5, and 7-9. 3-(5-Ethyl-2,4-dihydroxybenzoyl)benzoic acid, methyl ester, 43% yield, m.p. = 146-147°C. Analysis for C₁₇H₁₆O₅: Calculated: C, 67.99; H, 5.37; Found: C, 66.77; H, 5.56. 4-(5-Ethyl-2,4-dihydroxybenzoyl)benzoic acid, methyl ester, 21% yield, m.p. = 150-153°C. 2-(5-Ethyl-2,4-dihydroxybenzoyl)benzoic acid, methyl ester, 39% yield. 5-Butyl-2,4-dihydroxyacetophenone, 64% yield 5-Pentyl-2,4-dihydroxyacetophenone, 53% yield 5-Methyl-2,4-dihydroxyacetophenone, 48% yield 5-(5-Ethyl-2,4-dihydroxyphenyl)-5-oxopentanoic acid, methyl ester, 49% yield 5-Ethyl-2,4-dihydroxyacetophenone, 36% yield 5-Hexyl-2,4-dihydroacetophenone, 70% yield Preparation 4 4,6-Diacetoresorcinol A mixture of 3 g of 4,6-diacetoresorcinol, dimethyl ether (see Example 10), 50 ml of acetic acid, and 50 ml of 48% hydrobromic acid was refluxed for 2 hours. After concentration in vacuo , the residue was partitioned between ethyl acetate and a saturated sodium chloride solution. The layers were separated and the organic solution was washed with a saturated sodium bicarbonate solution. Evaporation of the solvent provided crude product which was purified by high pressure liquid chromatography over silica gel eluting with a 0-50% ethyl acetate in hexane gradient. The appropriate fractions were combined and concentrated in vacuo to provide 0.9 g of the desired title inter­ mediate, m.p. = 182-184°C. Analysis for C₁₀H₁₀O₄: Calculated: C, 61.85; H, 5.19; Found: C, 62.74; H, 5.45. Preparation 5 5-Acetyl-2,4-dihydroxybenzaldehyde To a mixture of 49.8 g of 2,4-dimethoxybenz­ aldehyde, 23.6 ml of acetyl chloride, and 1000 ml of methylene chloride cooled to approximately 0°C were added 119.7 g of aluminum chloride with stirring under a nitrogen atmosphere. The reaction was allowed to warm to room temperature while stirring overnight. The mixture was added to a slurry of ice and concentrated hydrochloric acid. The organic layer was separated and washed with a saturated sodium chloride solution, dried over sodium sulfate, and concentrated in vacuo . The residue was purified by high pressure liquid chroma­ tography over silica gel eluting with a 0-40% ethyl acetate in hexane gradient. The appropriate fractions were pooled and concentrated to provide 5.85 g of the desired title intermediate, m.p. = 142-143°C. Preparation 6 5-Acetyl-2,4-dihydroxybenzyl alcohol One gram of 5-acetyl-2,4-dihydroxybenzaldehyde was hydrogenated in the presence of 1 g of 10% palladium on carbon in 150 ml of ethanol. After about 1 hour, hydrogen uptake ceased and hydrogenation was terminated. The reaction mixture was filtered and concentrated in vacuo . The residue was dissolved in approximately 30 ml of ethyl acetate and cooled in the refrigerator. The resulting solid was recovered by filtration afford­ ing 0.66 g of the desired title intermediate, m.p. = 151-152°C. The same reaction when run on a 5-fold scale provide 2.76 g of material. Analysis for C₉H₁₀O₄: Calculated: C, 59.34; H, 5.53; Found: C, 59.29; H, 5.74. Example 1 5-Butyl-2,4-dimethoxyacetophenone A. Preparation of 2,4-dimethoxybutyrophenone. One hundred grams of meta-dimethoxybenzene and 84.86 g of butyryl chloride were added to 1000 ml of methylene chloride. The solution was cooled to 0°C by means of an external acetone/ice bath. With stir­ ring, 144.76 g of aluminum chloride were added in por­ tions over 1 hour. After all of the aluminum chloride was added, the mixture was stirred at 0°C for 2.5 hours. The mixture was poured into a mixture of ice and concen­ trated hydrochloric acid. The layers were separated and the organic layer was washed sequentially with a satu­ rated potassium carbonate solution and a saturated sodium chloride solution, dried over magnesium sulfate, and concentrated in vacuo providing 142.3 g of a crude oil which was used in the subsequent reaction without further purification. B. Preparation of 1-(2,4-dimethoxyphenyl)-1-butanol. The 142.3 g of crude product from Example 1A were dissolved in 800 ml of methanol. After cooling to approximately 0°C, 31.02 g of sodium borohydride were added in portions. The reaction mixture was allowed to warm to room temperature and stirred over­ night. An additional 6.46 g of sodium borohydride were added and the reaction was stirred for 2 days at room temperature. The reaction mixture was heated at reflux for three hours and then concentrated in vacuo . The residue was triturated with cold 1N hydro­ chloric acid and extracted into ethyl acetate. The organic layer was washed with water, dried over mag­ nesium sulfate, and concentrated in vacuo to provide 137.5 g of the subtitle intermediate which was used without further purification. C. Preparation of 1-butyl-2,4-dimethoxybenzene. In five portions, 137.5 g of the intermediate of Example 1B were catalytically hydrogenated in glacial acetic acid. Each portion employed about 5 g of 5% palladium on carbon as the catalyst. Hydrogenation of each portion was complete within about 30-40 minutes. The reactions were combined, filtered, and concentrated in vacuo . The residue was triturated with cold 1N hydrochloric acid and treated with ethyl acetate. The layers were separated and the organic layer was washed with a sodium bicarbonate solution followed by a sodium chloride solution. After drying over magnesium sulfate, the solution was concentrated in vacuo to provide 106.1 g of the desired subtitle intermediate which was used in the subsequent step without further purification. D. Preparation of 5-butyl-2,4-dimethoxyacetophenone. The 106.1 g of intermediate from Example 1C and 42.87 g of acetyl chloride were dissolved in 1000 ml of methylene chloride. The reaction mixture was cooled to -15°C by means of an external ethylene glycol/dry ice bath. In portions, 80.06 g of aluminum chloride were added over 90 minutes at a rate to maintain the tempera­ ture between -12° and -18°C. The reaction mixture was poured into a mixture of ice and concentrated hydrochloric acid. The layers were separated and the organic layer was washed with a potassium carbonate solution followed by a saturated sodium chloride solution. After drying over magnesium sulfate, the organic solution was con­ centrated in vacuo to provide 120.1 g of an oil which solidified upon standing. Twenty grams of this material was purified by high pressure liquid chromatography over silica gel eluting with a 0-100% ethyl acetate and hexane step gradient to provide 8.42 g of the purified title product. Examples 2-9 Following the procedure of Example 1D, the following compounds were prepared from the appropriate benzene derivative and the corresponding acid chloride or acid anhydride. 2. 5-Hexyl-2,4-dimethoxyacetophenone, 39% yield. 3. 5-Pentyl-2,4-dimethoxyacetophenone, 19% yield. 4. 5-Methyl-2,4-dimethoxyacetophenone, 32% yield. 5. 3-(5-Ethyl-2,4-dimethoxybenzoyl)benzoic acid, methyl ester, 63% yield, m.p. = 116-118°C. Analysis for C₁₉H₂₀O₅: Calculated: C, 69.50; H, 6.14; Found: C, 67.59; H, 5.43. 6. 6-(5-Ethyl-2,4-dimethoxyphenyl)-6-oxo-­ hexanoic acid, methyl ester, 56% yield, m.p. = 57-58°C. Analysis for C₁₇H₂₄O₅: Calculated: C, 66.21; H, 7.85; Found: C, 63.09; H, 6.57. 7. 4-(5-Ethyl-2,4-dimethoxybenzoyl)benzoic acid, methyl ester, 53% yield, m.p. = 128-130°C. Analysis for C₁₉H₂₀O₅: Calculated: C, 69.50; H, 6.14; Found: C, 67.62; H, 7.38. 8. 2-(5-Ethyl-2-hydroxy-4-methoxybenzoyl)-­ benzoic acid, 24% yield, m.p. = 194-197°C. Analysis for C₁₇H₁₆O₅: Calculated: C, 67.99; H, 5.37; Found: C, 67.70; H, 5.65. 9. 5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-5-­ oxopentanoic acid, 29% yield, m.p. = 124-128°C. Analysis for C₁₄H₁₈O₅: Calculated: C, 63.14; H, 6.81; Found: C, 64.48; H, 7.22. Example 10 4,6-Diacetoresorcinol, dimethyl ether Following the general procedure of Example 1D, 100 g of meta-dimethoxybenzene, 62.5 g of acetyl chloride, and 106.16 g of aluminum chloride were reacted in 1000 ml of dichloromethane. After workup, the material was crystallized from ethyl acetate/hexane to provide 89.8 g of crude material. Forty-five grams of this material was purified by high pressure liquid chromatography over silica gel eluting with a 0-20% ethyl acetate in hexane gradient. The less polar material was recovered and identified as 2,4-dimethoxy­ acetophenone. The material remaining on the chroma­ tography column was eluted with ethyl acetate and provided 10 g of the desired title product. Examples 11-15 The following compounds were prepared from the appropriate benzene derivative and corresponding acid chloride or acid anhydride according to the pro­ cedure of Example 1D. 11. 5-Acetyl-2,4-dihydroxybenzaldehyde, 12.8% yield, m.p. = 134-136°C. Analysis for C₉H₈O₄: Calculated: C, 60.00; H, 4.98; O, 35.52; Found: C, 59.87; H, 4.55; O, 35.61. 12. 5-[4-(4-Cyanobutoxy)-5-allyl-2-methoxy­ phenyl]-5-oxopentanoic acid, 8.4% yield. 13. 5-(2-Allyl-4-propanoyl-5-methoxyphenoxy)­ pentanenitrile, 22.8% yield. Analysis for C₁₈H₂₃NO₃: Calculated: C, 71.73; H, 7.69; N, 4.65; Found: C, 71.56; H, 7.59; N, 4.44. 14. 5-(2-Allyl-4-benzoyl-5-methoxyphenoxy)­ pentanenitrile, 11.2% yield. 15. 5-(4-Acetyl-5-chloro-2-propylphenoxy)­ pentanenitrile, 40.8% yield, oil. Analysis for C₁₆H₂₀ClNO₂: Calculated: C, 65.41; H, 6.86; N, 4.77; Cl, 12.07; Found: C, 66.26; H, 7.06; N, 5.04; Cl, 11.84. Example 16 5-(2,4-Diacetyl-5-hydroxyphenoxy)pentane­ nitrile A mixture of 582 mg of 4,6-diacetylresorcinol, 460 mg of potassium carbonate, 530 mg of 5-bromopentane­ nitrile and 0.2 g of potassium iodide was heated at reflux overnight. The mixture was concentrated in vacuo and partitioned between ethyl acetate and dilute hydrochloric acid. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo The residue was purified by preparative thin layer chromatography on silica gel eluting with 40% ethyl acetate in hexane to provide 200 mg of the desired title product, m.p. = 105-106°C. Analysis for C₁₅H₁₇NO₄: Calculated: C, 65.44; H, 6.22; N, 5.09; Found: C, 65.61; H, 6.28; N, 5.33. Examples 17-67 The following compounds were prepared according to the procedure of Example 16 employing the appropriate phenol and the corresponding halo alkane derivative. 17. 5-[4-Acetyl-5-hydroxy-2-(hydroxymethyl)­ phenoxy]pentanenitrile, 44% yield, m.p. = 72-74°C. Analysis for C₁₄H₁₇NO₄: Calculated: C, 63.87; H, 6.51; N, 5.32; Found: C, 63.67; H, 6.34; N, 5.31. 18. 5-(4-Acetyl-5-hydroxy-2-formylphenoxy)­ pentanenitrile, 3% yield. Analysis for C₁₄H₁₅NO₄: Calculated: C, 64.36; H, 5.79; Found: C, 63.04; H, 6.02. 19. 5-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ pentanenitrile, 50% yield, m.p. = 83-84.5°C. Analysis for C₁₅H₁₉NO₃: Calculated: C, 68.94; H, 7.33; N, 5.36; Found: C, 69.74; H, 6.94; N, 5.17. 20. 7-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ heptanenitrile, 50% yield, m.p. = 56-57°C. Analysis for C₁₇H₂₃NO₃: Calculated: C, 70.56; H, 8.01; N, 4.84; Found: C, 70.60; H, 8.31; N, 4.70. 21. 6-(4-Acetyl-5-hydroxy-2-allylphenoxy)­ hexanenitrile, 45.8% yield, m.p. = 70-71°C. Analysis for C₁₇H₂₁NO₃: Calculated: C, 71.06: H, 7.37; N, 4.07: Found: C, 70.B7: H, 7.47: N, 4.70. 22. 5,5′-[(4-Acetyl-6-formyl-1,3-phenylene)­ bis(oxy)]bis[pentanenitrile], 75% yield, m.p. = 86-88°C. Analysis for C₁₉H₂₂N₂O₄: Calculated: C, 66.65; H, 6.48; N, 8.18; Found: C, 66.98; H, 6.25; N, 7.96. 23. 9-(4-Acetyl-5-hydroxy-2-allylphenoxy)­ nonanenitrile, 6% yield, m.p. = 50-52°C. Analysis for C₂₀H₂₇NO₃: Calculated: C, 72.92; H, 8.26; N, 4.25; Found: C, 72.65; H, 8.49; N, 4.00. 24. 7-(4-Acetyl-5-hydroxy-2-allylphenoxy)­ heptanenitrile, 39% yield, m.p. = 54-55°C. Analysis for C₁₈H₂₃NO₃: Calculated: C, 71.73; H, 7.69; N, 4.65; Found: C, 71.85; H, 7.66; N, 4.51. 25. (4-Acetyl-5-hydroxy-2-allylphenoxy)­ acetonitrile, 45% yield, m.p. = 66-68°C. Analysis for C₁₃H₁₃NO₃: Calculated: C, 67.52; H, 5.67; N, 6.06; Found: C, 67.31; H, 5.39; N, 5.92. 26. 4-(4-Acetyl-5-hydroxy-2-allylphenoxy)­ butanenitrile, 7% yield, m.p. = 92-94°C. Analysis for C₁₅H₁₇NO₃: Calculated: C, 69.48; H, 6.61; N, 5.40; Found: C, 69.96; H, 7.74; N, 6.46. 27. 5-[4-(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzene]-5-oxopentanoic acid, methyl ester, 79% yield, m.p. = 50-52°C. Analysis for C₁₉H₂₅NO₅: Calculated: C, 65.69: H, 7.25: N, 4.03; Found: C, 65.82; H, 7.48; N, 4.26. 28. 5-(4-Acetyl-2-methyl-5-hydroxyphenoxy)­ pentanenitrile, 71% yield, m.p. = 86-87°C. Analysis for C₁₄H₁₇NO₃: Calculated: C, 68.00; H, 6.93; N, 5.66; Found: C, 67.77; H, 6.84; N, 5.38. 29. 5-(4-Acetyl-2-hexyl-5-hydroxyphenoxy)­ pentanenitrile, 75% yield, m.p. = 45-49°C. Analysis for C₁₉H₂₇NO₃: Calculated: C, 71.89; H, 8.57; N, 4.41; Found: C, 71.82; H, 8.74; N, 4.29. 30. 5-(4-Acetyl-2-butyl-5-hydroxyphenoxy)­ pentanenitrile, 73% yield, m.p. 57-60°C. Analysis for C₁₇H₂₃NO₃: Calculated: C, 70.56; H, 8.01; N, 4.84; Found: C, 70.79; H, 7.79; N, 4.89. 31. 5-(4-Acetyl-5-hydroxy-2-pentylphenoxy)­ pentanenitrile, 58% yield, m.p. = 34-37°C. Analysis for C₁₈H₂₅NO₃: Calculated: C, 71.26; H, 8.31; N, 4.62; Found: C, 71.49; H, 8.41; N, 4.70. 32. 6-[4-(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzene]-6-oxohexanoic acid, methyl ester, 77.8% yield, m.p. = 90-94°C. 33. 2-[4-(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzoyl]benzoic acid, methyl ester, 31.5% yield. 34. 3-[4-(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzoyl]benzoic acid, methyl ester, 85.7% yield, m.p. = 88-90°C. 35. 4-[4-(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzoyl]benzoic acid, methyl ester, 31.5% yield. 36. 7-[4-Acetyl-5-hydroxy-2-(hydroxymethyl)­ phenoxy]heptanenitrile, 69% yield, m.p. = 58-60°C. Analysis for C₁₆H₂₁NO₄: Calculated: C, 65.96; H, 7.27; N, 4.81; Found: C, 65.96; H, 7.04; N, 4.70. 37. 4-(Heptyloxy)-2-hydroxy-5-allylaceto­ phenone, 40% yield, oil. Analysis for C₁₈H₂₆O₃: Calculated: C, 74.45; H, 9.02; Found: C, 74.31; H, 8.79. 38. 4-(Octyloxy)-5-allyl-2-hydroxyaceto­ phenone, 21% yield, oil. Analysis for C₁₉H₂₈O₃: Calculated: C, 74.96; H, 9.27; Found: C, 74.99; H, 9.00. 39. 4-(Hexyloxy)-2-hydroxy-5-allylacetophenone, 36% yield, m.p. = 42-44°C. Analysis for C₁₇H₂₄O₆: Calculated: C, 73.88; H, 8.75; Found: C, 73.96; H, 8.93. 40. 4-Butoxy-2-hydroxy-5-allylacetophenone, 60% yield, oil. Analysis for C₁₅H₂₀O₃: Calculated: C, 72.55; H, 8.12: Found: C, 72.60: H, 7.83. 41. 4-Pentyloxy-2-hydroxy-5-allylaceto­ phenone, 44% yield, oil. Analysis for C₁₆H₂₂O₃: Calculated: C, 73.25; H, 8.45; Found: C, 73.52; H, B.41. 42. 2-Hydroxy-4-methoxy-5-allylacetophenone, 41% yield. Analysis for C₁₂H₁₄O₆: Calculated: C, 69.89; H, 6.84; Found: C, 69.87; H, 6.72. 43. 2,4-Dimethoxy-5-allylacetophenone, 2% yield. Analysis for C₁₃H₁₆O₃: Calculated: C, 70.89; H, 7.32; Found: C, 70.14; H, 7.00. 44. 4-(4-Hydroxybutoxy)-5-allyl-2-hydroxy­ acetophenone, 5% yield, m.p. = 117-119°C. Analysis for C₁₅H₂₀O₄: Calculated: C, 68.16; H, 7.63; Found: C, 68.38; H, 7.85. 45. 4-(3-Butenyloxy)-2-hydroxy-5-allyl­ acetophenone, 26% yield, m.p. = <25°C. Analysis for C₁₅H₁₈O₃: Calculated: C, 73.15; H, 7.37: Found: C, 72.88; H, 7.45. 46. 4-(5-Hexenyloxy)-2-hydroxy-5-allyl­ acetophenone, 30% yield, m.p. = <25°C. Analysis for C₁₇H₂₂O₃: Calculated: C, 74.42; H, 8.08; Found: C, 74.16; H, 8.13. 47. 2-Hydroxy-4-benzyloxy-5-allylaceto­ phenone, 60% yield, m.p. = 86°C. Analysis for C₁₈H₁₈O₃: Calculated: C, 76.57; H, 6.43; Found: C, 76.47; H, 6.19. 48. 4-[(4-Acetyl-5-hydroxy-2-allylphenoxy)­ methyl]benzonitrile, 63% yield, m.p. = 158.5-159°C. Analysis for C₁₉H₁₇NO₃: Calculated: C, 74.25; H, 5.58; N, 4.56; Found: C, 74.48; H, 5.80; N, 4.67. 49. 2-[(4-Acetyl-5-hydroxy-2-allylphenoxy)­ methyl]benzonitrile, 71% yield, m.p. = 159°C. Analysis for C₁₉H₁₇NO₃: Calculated: C, 74.25; H, 5.58; N, 4.56; Found: C, 74.37; H, 5.86; N, 4.39. 50. 3-[(4-Acetyl-5-hydroxy-2-allylphenoxy)­ methyl]benzonitrile, 51% yield, m.p. = 131.5°C. Analysis for C₁₉H₁₇NO₃: Calculated: C, 74.25; H, 5.58; N, 4.56; Found: C, 74.39; H, 5.55; N, 4.28. 51. 2-Hydroxy-4-(3-methylbenzyloxy)-5-allyl­ acetophenone, 50% yield, m.p. = 87-88°C. Analysis for C₁₉H₂₀O₃: Calculated: C, 77.00; H, 6.80; Found: C, 77.03; H, 7.05. 52. 4-[4-(Bromomethyl)benzyloxy]-2-hydroxy-­ 5-allylacetophenone, 18% yield, oil. Analysis for C₁₉H₁₉BrO₃: Calculated: C, 60.81; H, 5.10; Br, 21.29; Found: C, 60.74; H, 5.11; Br, 21.57. 53. 2-Hydroxy-4-(3-phenylpropoxy)-5-propyl­ acetophenone, 26% yield, m.p. = 60°C. Analysis for C₂₀H₂₄O₃: Calculated: C, 76.89; H, 7.74; Found: C, 76.68; H, 7.69. 54. 5-Ethyl-4-(3-fluorobenzyloxy)-2-hydroxy­ acetophenone, 18% yield, m.p. = 104-105°C. Analysis for C₁₇H₁₇FO₃: Calculated: C, 70.82; H, 5.94; Found: C, 70.54; H, 6.10. 55. 3-[(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ methyl]benzonitrile, 80% yield, m.p. = 155-155.5°C. Analysis for C₁₈H₁₇NO₃: Calculated: C, 73.20; H, 5.80; N, 4.74; Found: C, 72.92; H, 5.98; N, 4.68. 56. 4-(3-Chlorobenzyloxy)-5-ethyl-2-hydroxy­ acetophenone, 47% yield. Analysis for C₁₇H₁₇ClO₃: Calculated: C, 67.00; H, 5.62; Found: C, 67.13; H, 5.33. 57. 4-(5-Hexynyloxy)-2-hydroxy-5-allylaceto­ phenone, 20% yield, m.p. = <25°C. NMR. 58. 5-Ethyl-2-hydroxy-4-(3-trifluoromethyl­ benzyloxy)acetophenone, 11% yield. Analysis for C₁₈H₁₇F₃O₃: Calculated: C, 63.90: H, 5.06: Found: C, 62.9; H, 5.53. 59. 4-(3-Methylmercaptobenzyloxy)-5-ethyl-­ 2-hydroxyacetophenone, 18.5% yield, m.p. = 89°C. NMR. 60. 3-[(4-Acetyl-5-hydroxy-2-allylphenoxy)­ methyl]benzeneacetonitrile. NMR. 61. 4-(2-Bromoethoxy)-5-ethyl-2-hydroxy­ acetophenone, 42.5% yield, m.p. = 58-59°C. NMR. 62. 4-(3-Bromopropoxy)-5-ethyl-2-hydroxy­ acetophenone, 80.3% yield, m.p. = 126-127°C. NMR. 63. 4-(5-Bromopentoxy)-5-ethyl-2-hydroxy­ acetophenone, 59.7% yield, m.p. = 60-62°C. NMR. 64. 4-(10-Bromodecyloxy)-5-allyl-2-hydroxy­ acetophenone, 18% yield, m.p. = <25°C. NMR. Analysis for C₂₁H₃₁BrO₃: Calculated: C, 61.31; H, 7.60; Br, 19.42; Found: C, 58.76; H, 6.59; Br, 21.02. 65. 4-(7-Bromoheptyloxy)-5-allyl-2-hydroxy­ acetophenone, 70% yield, oil. Analysis for C₁₈H₂₅BrO₃: Calculated: C, 58.54; H, 6.82; Br, 21.64; Found: C, 56.92; H, 6.33; Br, 22.32. 66. 4-(6-Bromohexyloxy)-5-allyl-2-hydroxy­ acetophenone, 42% yield. Analysis for C₁₇H₂₃BrO₃: Calculated: C, 57.47; H, 6.53; Br, 22.49; Found: C, 57.37; H, 6.63; Br, 22.60. 67. 4-(4-Bromobutoxy)-5-allyl-2-hydroxy­ acetophenone, 56% yield, m.p. = <25°C. Analysis for C₁₅H₁₉BrO₃: Calculated: C, 55.03; H, 5.85; Br, 24.42; Found: C, 54.43; H, 5.87; Br, 24.93. Example 68 4-(6-Cyano-6-methylheptyloxy)-5-ethyl-2-­ hydroxyacetophenone Approximately 300 ml of ammonia were condensed in a 1 liter flask fitted with a mechanical stirrer and reflux condenser. A pinch of ferric chloride was added to the solution with stirring followed by the piece-wise addition of 0.69 g of sodium metal. A solution of 1.36 ml of isobutyronitrile in 30 ml of diethyl ether was added dropwise followed by a slurry of 4.935 g of 4-(5-bromo­ pentoxy)-5-ethyl-2-hydroxyacetophenone in diethyl ether. The reaction was stirred overnight during which time the ammonia evaporated leaving an oil. The oil was par­ titioned between ethyl acetate and dilute cold hydro­ chloric acid. The organic layer was separated, dried over sodium sulfate, filtered, and concentrated in vacuo . The residue was purified by high pressure liquid chromatography over silica gel eluting with a 0-25% ethyl acetate in hexane gradient providing 2.91 g of the desired title product, m.p. = 168-169°C. Analysis for C₁₉H₂₇NO₃: Calculated: C, 71.89; H, 8.57; N, 4.41; Found: C, 71.58; H, 8.70; N, 4.08. Example 69 8-(4-Acetyl-5-hydroxy-2-allylphenoxy)octane­ nitrile A mixture of 1.845 g of 4-(7-bromoheptyloxy-­ 5-allyl-2-hydroxyacetophenone, 0.651 g of potassium cyanide, 0.2 g of potassium iodide, and 25 ml of dimethylformamide was heated at 70°C for approximately 6 days. The mixture was then partitioned between ethyl acetate and cold dilute hydrochloric acid. The layers were separated and the organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo . The residue was purified by preparative thin layer chro­ matography on silica gel. Purification of the resulting material by crystallization from diethyl ether/hexane provided 190 mg of the desired title product, m.p. = 46-48°C. Analysis for C₁₉H₂₅NO₃: Calculated: C, 72.35; H, 7.99; N, 4.44; Found: C, 72.29; H, 7.72; N, 4.64. Examples 70 and 71 The following compounds are prepared according to the procedure of Example 69 from the appropriate bromide derivative and potassium or sodium cyanide. 70. 11-(4-Acetyl-5-hydroxy-2-allylphenoxy)­ undecanenitrile, 3.9% yield. Analysis for C₂₂H₃₁NO₃: Calculated: C, 73.92; H, 8.74; N, 3.92; Found: C, 73.83; H, 8.53; N, 3.93. 71. 4-[(4-Acetyl-5-hydroxy-2-allylphenoxy)­ methyl]benzeneacetonitrile, 20% yield, m.p. = 142-144°C. NMR. Example 72 4-(3-Azidopropoxy)-5-ethyl-2-hydroxyaceto­ phenone A mixture of 2.107 g of 4-(3-bromopropoxy)-­ 5-ethyl-2-hydroxyacetophenone and 0.5 g of sodium azide in 30 ml of dimethylformamide was stirred together overnight at room temperature. The mixture was partitioned between ethyl acetate and dilute hydro­ chloric acid. The layers were separated and the organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo providing the desired title product. The proton NMR and mass spectral analyses were consistent with the structure of the desired product. Example 73 4-(2-Azidoethoxy)-5-ethyl-2-hydroxyaceto­ phenone The title product was prepared from 2 g of 4-(2-bromoethoxy)-5-ethyl-2-hydroxyacetophenone according to the procedure of Example 72. The proton nmr and mass spectral analyses were consistent with the structure of the desired product. Example 74 4-(4-Aminobutoxy)-2-hydroxy-5-propylaceto­ phenone hydrochloride A mixture of 1.64 g of 4-(4-bromobutoxy)-­ 2-hydroxy-5-allylacetophenone and 0.325 g of sodium azide and 25 ml of dimethylformamide was reacted accord­ ing to the procedure of Example 72. After workup, the resulting product was hydrogenated over 1 g of 5% pal­ ladium on carbon in 100 ml of 2B ethanol for 4 hours. The reaction mixture was filtered and concentrated in vacuo . The residue was dissolved in diethyl ether and extracted into acid. The acidic portion was made basic and extracted into diethyl ether. The organic solution was dried over sodium sulfate and concentrated in vacuo . The residue was dissolved in diethyl ether and hydrogen chloride gas was bubbled through the solution. Evap­ oration of the solvent and crystallation of the residue from ethanol/diethyl ether provided 0.36 g of the desired product, m.p. = 87-88°C. Analysis for C₁₅H₂₃NO₃·HCl: Calculated: C, 60.10; H, 7.40; N, 4.67; Found: C, 60.22; H, 7.60; N, 4.68. Example 75 2-Hydroxy-4-[4-(4-morpholino)butoxy]-5-allyl­ acetophenone hydrochloride A mixture of 1.64 g of 4-(4-bromobutoxy)-5-­ allyl-2-hydroxyacetophenone and 15 ml of morpholine were stirred overnight. Diethyl ether was added and the solution was washed twice with a saturated sodium chloride solution. The organic layer was extracted with cold dilute hydrochloric acid. The acid solution was made basic with potassium carbonate and extracted with diethyl ether. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo . The product was treated with hydrogen chloride gas in diethyl ether. Crystallization from ethanol/diethyl ether provided 1.28 g of the desired title product, m.p. = 140-141°C. Analysis for C₁₉H₂₇NO₄·HCl: Calculated: C, 61.70; H, 7.63; N, 3.79; Found: C, 60.14; H, 7.06; N, 3.55. Example 76 4-[4-(Dimethylamino)butoxy]-2-hydroxy-5-­ allylacetophenone hydrochloride Following the procedure of Example 75, 1.32 g of the desired title product was recovered when 100 g of dimethylamine were substituted for morpholine, m.p. = 88-90°C. Analysis for C₁₇H₂₅NO₃·HCl: Calculated: C, 62.28; H, 7.99; N, 4.27; Found: C, 61.06; H, 9.19; N, 5.53. Example 77 N-[4-(4-Acetyl-5-hydroxy-2-propylphenoxy)­ butyl]acetamide Approximately 100 milligrams of 4-(4-amino­ butoxy)-5-propyl-2-hydroxyacetophenone hydrochloride were treated with acetyl chloride and sodium bicarbonate in acetone. After stirring 48 hours, the mixture was con­ centrated in vacuo and partitioned between ethyl acetate and saturated sodium chloride solution. The organic layer was separated, washed with dilute hydrochloric acid followed by a saturated potassium carbonate solu­ tion, and concentrated to dryness. Preparative thin layer chromatography over silica gel eluting with 1:1 ethyl acetate/hexane provided 10 mg of the desired title product. Analysis for C₁₇H₂₅NO₄: Calculated: C, 66.43; H, 8.20; N, 4.56; Found: C, 65.73; H, 7.60; N, 3.83. Example 78 2-Hydroxy-4-[6-(methylthio)hexyloxy]-5-allyl­ acetophenone Ten grams of methane thiol in 25 ml of di­ methylformamide were treated with 0.83 g of a 50% sodium hydride dispersion in oil at 0°C under a nitrogen atmosphere. The reaction was brought to room tempera­ ture, and, after stirring two hours, a mixture of 1.5 g of 4-(6-bromohexyloxy)-5-allyl-2-hydroxyacetophenone in 25 ml of dimethylformamide was added. The mixture was heated under a nitrogen atmosphere at 70°C for 24 hours. After cooling to room temperature, the mixture was partitioned between ethyl acetate and dilute hydro­ chloric acid. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo . The residue was purified by preparative thin layer chroma­ tography over silica gel providing 0.73 g of the desired title product, m.p. = 42°C. Analysis for C₁₈H₂₆O₃S: Calculated: C, 67.04; H, 8.13; S, 9.94; Found: C, 67.13; H, 8.39; S, 10.16. Examples 79 and 80 2-Hydroxy-4-[6-(methylsulfinyl)hexyloxy]-5-­ allylacetophenone and 2-hydroxy-4-[6-(methylsulfonyl)­ hexyloxy]-5-allylacetophenone A mixture of 0.322 g of 2-hydroxy-4-[6-­ (methylthio)hexyloxy]-5-allylacetophenone in 50 ml of methylene chloride was cooled to 0°C. A solution of 0.216 g of 80% meta-chloroperbenzoic acid in 50 ml of methylene chloride was added over a 30 minute period. The reaction mixture was allowed to warm to room temperature and stirred overnight. The reaction mixture was concentrated in vacuo and partitioned between ethyl acetate and a sodium bicarbonate solution. The organic layer was separated, dried over sodium sul­ fate, and concentrated in vacuo . The residue was puri­ fied by preparative thin layer chromatography eluting with 1:1 ethyl acetate/hexane providing 30 mg of the title sulfoxide and 70 mg of the title sulfone. 79. 2-Hydroxy-4-[6-(methylsulfinyl)hexyloxy]-­ 5-allylacetophenone. Analysis for C₁₈H₂₆O₄S: Calculated: C, 63.88: H, 7.74: S, 9.47: Found: C, 62.29: H, 7.45: S, 10.42. 80. 2-Hydroxy-4-[6-(methylsulfonyl)hexyloxy]-­ 5-allylacetophenone. Analysis for C₁₈H₂₆O₅S: Calculated: C, 60.99; H, 7.39; S, 9.05; Found: C, 60.75; H, 7.25; S, 9.17. Examples 81-83 The following compounds were prepared from the corresponding bromo derivative according to the procedures of Examples 78-80. 81. 2-Hydroxy-4-[6-(methylthio)hexyloxy]-5-­ ethylacetophenone, 77.8% yield, m.p. = 52-53°C. NMR. 82. 2-Hydroxy-4-[6-(methylsulfinyl)hexyl­ oxy]-5-ethylacetophenone, 17% yield, m.p. = 87-90°C. Analysis for C₁₇H₂₆O₄S: Calculated: C, 62.55; H, 8.03; S, 9.82; Found: C, 62.46; H, 7.78; S, 9.65. 83. 2-Hydroxy-4-[6-(methylsulfonyl)hexyl­ oxy]-5-ethylacetophenone, 70% yield, m.p. = 124-126°C. Analysis for C₁₇H₂₆O₅S: Calculated: C, 59.62; H, 7.65; S, 9.36; Found: C, 59.66; H, 7.57; S, 9.42. Example 84 3-[(4-Acetyl-5-hydroxy-2-ethylphenoxy)­ methyl]benzoic acid A mixture of 1.5 g of 3-[(4-acetyl-5-hydroxy-­ 2-ethylphenoxy)methyl]benzonitrile, 1.14 g of potassium hydroxide, 75 ml of ethanol and 75 ml of water was heated at reflux overnight. The mixture was acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was extracted with 1N sodium hydroxide. The base layer was acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was dried over sodium sulfate and concentrated in vacuo providing 1.06 g of the desired title product, m.p. = 161-164°C. Analysis for C₁₈H₁₈O₅: Calculated: C, 68.78; H, 5.77; Found: C, 68.62; H, 5.65. Examples 85-87 The following acids were prepared from the corresponding nitriles according to the procedure of Example 84. 85. 7-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ heptanoic acid, 89% yield, m.p. = 86-88°C. Analysis for C₁₇H₂₄O₅: Calculated: C, 66.21; H, 7.85; Found: C, 65.31; H, 8.00. 86. 6-(4-Acetyl-2-allyl-5-hydroxyphenoxy)­ hexanoic acid, 73% yield, m.p. = 90-92°C. NMR. 87. 7-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-­ 2,2-dimethylheptanoic acid, 28% yield, m.p. = 110-112°C. Analysis for C₁₉H₂₈O₅: Calculated: C, 67.83; H, 8.39; Found: C, 66.68; H, 8.41. Example 88 5-[(4-Cyanobutoxy)-5-ethyl-2-hydroxybenzene]-­ 5-oxopentanoic acid To a solution of 347 mg of 5-[(4-cyanobutoxy)-­ 5-ethyl-2-hydroxybenzene]-5-oxopentanoic acid, methyl ester in 6 ml of acetone were added 1.5 ml of water followed by 50 mg of lithium hydroxide. After stirring for 1 hour, 2 ml of water were added and the reaction was stirred an additional 3 hours. The solution was concentrated in vacuo , diluted with water to 30 ml, and treated with dilute hydrochloric acid. The resulting precipitate was shaken with ethyl acetate. The organic layer was separated and extracted into a potassium carbonate solution. The potassium carbonate layer was treated with dilute hydrochloric acid and the resulting precipitate was extracted into ethyl acetate. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo . The resulting solid was crystallized from diethyl ether providing the 0.19 g of the desired title product, m.p. = 140-142°C. Analysis for C₁₈H₂₃NO₅: Calculated: C, 64.85; H, 6.95; N, 4.20; Found: C, 64.73; H, 7.18; N, 4.46. Examples 89-92 The following acids were prepared according to the procedure of Example 88 from the corresponding esters. 89. 2-[4-(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzoyl]benzoic acid, 14% yield, m.p. = 162-166°C. Analysis for C₂₁H₂₁NO₅: Calculated: C, 68.65; H, 5.76; N, 3.81; Found: C, 68.38; H, 5.51; N, 4.10. 90. 6-[(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzene]-6-oxohexanoic acid, 63% yield, m.p. = 120-121°C. Analysis for C₁₉H₂₅NO₅: Calculated: C, 65.69; H, 7.25; N, 4.03; Found: C, 65.70; H, 6.99; N, 3.77. 91. 4-[4-(4-Cyanobutoxy)-5-ethyl-2-hydroxy­ benzoyl]benzoic acid, 2% yield. NMR. 92. 3-[4-(4-Cyanobutoxy-5-ethyl-2-hydroxy­ benzoyl]benzoic acid, 49% yield, m.p. = 136-139°C. Analysis for C₂₁H₂₁NO₅: Calculated: C, 68.65; H, 5.76; N, 3.81; Found: C, 68.87; H, 5.91; N, 3.53. Example 93 3-[(4-Acetyl-3-ethyl-5-hydroxyphenoxy)methyl]­ benzoic acid, methyl ester A mixture of 0.25 g of 3-[(4-acetyl-2-ethyl-­ 5-hydroxyphenoxy)methyl]benzoic acid, six drops of sul­ furic acid, and 50 ml of methanol were heated at reflux overnight. The solvent was removed in vacuo and the residue was dissolved in ethyl acetate. The organic solution was washed with base, and concentrated in vacuo . The residue was crystallized from acetone pro­ viding 210 mg of the desired title product, m.p. 132.5°C. Analysis for C₁₉H₂₀O₅: Calculated: C, 69.5: H, 6.14; N, 0; Found: C,.68.6; H, 6.18; N, 1.19. Example 94 6-(4-Acetyl-5-hydroxy-2-allylphenoxy)hexanoic acid, methyl ester The title product was prepared from the cor­ responding acid following the procedure of Example 93, 78.4% yield, m.p. = 64-65°C. Analysis for C₁₈H₂₄O₅: Calculated: C, 67.48; H, 7.55; Found: C, 67.08; H, 6.98. Example 95 6-(4-Acetyl-5-hydroxy-2-allylphenoxy)hexanoyl chloride A mixture of 3.06 g of 6-(4-acetyl-5-hydroxy-­ 2-allylphenoxy)hexanoic acid, 1.74 ml of oxalyl chloride, 100 ml of methylene chloride, and ten drops of dimethyl­ formamide was mixed at 0°C and allowed to warm to room temperature. After stirring for 4 hours, the solvents were removed by evaporation to provide the desired title product. NMR. Example 96 6-(4-Acetyl-5-hydroxy-2-allylphenoxy)hexanamide Ammonia gas was bubbled into a solution of approximately 3 millimoles of the acid chloride from Example 95 in 25 ml of methylene chloride. After 10 minutes, gas introduction was discontinued and the reac­ tion was stirred overnight. The reaction mixture was concentrated in vacuo and then partitioned between ethyl acetate and dilute hydrochloric acid to which sodium chloride had been added. The organic layer was sepa­ rated, washed with a potassium carbonate solution, dried over sodium sulfate, and concentrated to dryness. The residue was purified by preparative thin layer chroma­ tography eluting with ethyl acetate to provide 110 mg of the desired title product, m.p. = 122-124°C. Analysis for C₁₇H₂₃NO₄: Calculated: C, 66.86; H, 7.59; N, 4.59; Found: C, 67.13; H, 7.57; N, 4.88. Examples 97-100 The following amide derivatives were prepared from the corresponding acid chloride and the appropriate amine following the procedure of Example 96. 97. 6-(4-Acetyl-5-hydroxy-2-allylphenoxy)-­ N,N-dimethylhexanamide, 21% yield, m.p. = 76°C. Analysis for C₁₉H₂₇NO₄: Calculated: C, 68.44; H, 8.16; N, 4.20; Found: C, 69.65; H, 8.39; N, 4.36. 98. 7-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-­ N,N-dimethylheptanamide, 48% yield, m.p. = 127-129°C. Analysis for C₁₉H₂₉NO₄: Calculated: C, 68.03; H, 8.71 N, 4.18; Found: C, 67.74; H, 8.70; N, 4.20. 99. 7-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-­ N-methylheptanamide, 6% yield, m.p. = 55-57°C. Analaysis for C₁₈H₂₇NO₄: Calculated: C, 67.26; H, 8.47; N, 4.36; Found: C, 67.05; H, 8.23; N, 4.21. 100. 6-(4-Acetyl-5-hydroxy-2-allylphenoxy)-­ N-hydroxyhexanamide, 7% yield, m.p. = 90-94°C. Analysis for C₁₇H₂₃NO₅: Calculated: C, 63.54; H, 7.21; N, 4.36; Found: C, 63.69; H, 7.05; N, 4.61. Example 101 7-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-­ dimethylheptanamide A mixture of 500 mg of 7-(4-acetyl-2-ethyl-­ 5-hydroxyphenoxy)-2,2-dimethylheptanenitrile in 150 ml of 5N sodium hydroxide and 50 ml of ethanol was heated at reflux overnight. The ethanol was removed by evap­ oration, 100 ml of water were added, and the solution was extracted with diethyl ether. The organic layer was separated, dried, and concentrated in vacuo . The residue was purified by preparative thin layer chroma­ tography over silica gel eluting with 1:1 ethyl acetate/­ hexane to provide 34 mg of the desired title product, m.p. = 73-74°C. Proton nmr and mass spectral analyses were consistent with the structure of the desired product. Examples 102 and 103 7-(4-Acetyl-5-hydroxy-2-allylphenoxy)-2-­ heptanone and 2-hydroxy-4-(6-hydroxy-6-methylheptyl­ oxy)-5-allylacetophenone A mixture of approximately 5 millimoles of 6-(4-acetyl-5-hydroxy-2-allylphenoxy)hexanoyl chloride in 100 ml of diethyl ether was cooled to -78°C by means of a dry ice/acetone bath. Under a nitrogen atmosphere, 8.56 ml of a 1.8N solution of methyllithium in diethyl ether was added. The reaction was allowed to warm to -50°C. over a one hour period. The mixture was poured into dilute hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride solution, dried over sodium sulfate, and concentrated in vacuo . The residue was purified by preparative thin layer chromatography over silica gel eluting with 40% ethyl acetate in hexane providing 130 mg of the title carbinol and 30 mg of the title ketone. 102. 7-(4-Acetyl-5-hydroxy-2-allylphenoxy)-2-­ heptanone. Analysis for C₁₈H₂₄O₄: Calculated: C, 71.03; H, 7.95; Found: C, 70.75; H, 7.86. 103. 2-Hydroxy-4-(6-hydroxy-6-methylheptyl-­ oxy)-5-allylacetophenone. Analysis for C₁₈H₂₄O₄: Calculated: C, 71.22; H, 8.81; Found: C, 70.95; H, 8.95. Example 104 5-(4-Benzoyl-5-hydroxy-2-allylphenoxy)pentane­ nitrile A mixture of 0.22 g of 5-(4-benzoyl-5-methoxy-­ 2-allylphenoxy)pentanenitrile, 2.52 ml of a 1M solution of boron tribromide in dichloromethane, and 50 ml of methylene chloride were stirred at -78°C for two hours. The solution was poured into a cold saturated ammonium chloride solution and ice. The mixture was extracted with ethyl acetate, the organic layer was washed with a cold saturated ammonium chloride solution followed by a saturated sodium chloride solution, dried and concen­ trated in vacuo . The residue was purified by prepara­ tive thin layer chromatography over silica gel eluting with 1:1 ethyl acetate/hexane providing 50 mg of the desired title product, m.p. = 60-62°C. NMR, MS. Examples 105-107 The following compounds were prepared from the corresponding methoxy derivatives according to the procedure of Example 104. 105. 5-[5-Hydroxy-4-(1-oxopropyl)-2-allyl­ phenoxy]pentanenitrile, 4% yield. NMR, MS. 106. 5-[4-(4-Cyanobutoxy)-2-hydroxy-5-allyl­ phenyl)-5-oxopentanoic acid, 11% yield. NMR, MS. 107. 5-[5-Hydroxy-4-(1-oxodecyl)-2-allyl­ phenoxy]pentanenitrile, 4% yield, m.p. = 49-51°C. NMR, MS. Example 108 5-Ethyl-2-hydroxy-4-[6-methyl-6-(1H-tetrazol-­ 5-yl)heptyloxy]acetophenone A mixture of 317 mg of 7-(4-acetyl-2-ethyl-­ 5-hydroxyphenoxy)-2,2-dimethylheptanenitrile and 996 mg of tributyltinazide was heated at 80°C for 9 days. After cooling, the reaction mixture was stirred with a few milliliters of methanol for 15 minutes. The mix­ ture was concentrated in vacuo and the residue was puri­ fied by high pressure liquid chromatography over silica gel eluting with a 0-70% ethyl acetate in hexane gradi­ ent with 0-1% acetic acid added. The appropriate frac­ tions were combined and concentrated in vacuo and the resulting residue was crystallized from methylene chloride/hexane to provide 16 mg of the desired title product, m.p. = 160-162°C. NMR, MS. Example 109 2-Hydroxy-5-allyl-4-[4-(1H-tetrazol-5-yl)-­ butoxy]acetophenone A mixture of 8.19 g of 5-(4-acetyl-5-hydroxy-­ 2-allylphenoxy)pentanenitrile, 4.86 g of ammonium chlo­ ride, and 5.85 g of sodium azide in 50 ml of dimethyl­ formamide was heated at 120°C overnight. An additional 4.86 g of ammonium chloride and 5.85 g of sodium azide were added and the reaction was stirred an additional 6 hours. The solvent was removed in vacuo and the residue was partitioned between ethyl acetate and dilute cold hydrochloric acid. The organic layer was extracted with a potassium carbonate solution. The aqueous layer was acidified with dilute hydrochloric acid and ex­ tracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered, and concentrated to dryness. Crystallization of the residue from diethyl ether/hexane provided 1.1 g of the desired title pro­ duct, m.p. = 140-141°C. Analysis for C₁₆H₂₀N₄O₃: Calculated: C, 60.75; H, 6.37; N, 17.71; Found: C, 60.55; H, 6.57; N, 17.61. Example 110 5-Ethyl-2-hydroxy-4-[4-(1H-tetrazol-­ 5-yl)butoxy]acetophenone The title compound was prepared by the proce­ dure of Example 109 from the corresponding nitrile in 29% yield, m.p. = 171-172°C. Analysis for C₁₅H₂₀N₄O₃: Calculated: C, 59.20; H, 6.62; N, 18.41; Found: C, 58.95; H, 6.35; N, 18.44. Example 111 5,5′-[(4-Acetyl-6-methoxymethyl-1,3-pheny­ lene)bis(oxy)]bis[pentanenitrile] A mixture of 688 mg of 5,5′-[(4-acetyl-6­ hydroxymethyl-1,3-phenylene)bis(oxy)]bis[pentanenitrile] in 15 ml of dimethylformamide was added to a suspension of 0.184 g of a 50% oil dispersion of sodium hydride and 0.62 ml of methyl iodide in 45 ml of dimethylformamide at 0°C. The reaction was allowed to come to room temperature and stirred overnight. The reaction mixture was partitioned between ethyl acetate and dilute hydro­ chloric acid to which sodium chloride had been added. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo . The resulting residue was purified by high pressure liquid chroma­ tography over silica gel eluting with a 0-70% ethyl acetate in hexane gradient to provide 110 mg of the desired title product. NMR, MS. Example 112 7-(4-Acetyl-5-methoxy-2-methoxymethylphenoxy)­ heptanenitrile The title product was prepared in 25.1% yield from the corresponding hydroxymethyl analog according to the procedure of Example 111. NMR. Example 113 5-(4-Acetyl-5-methoxy-2-allylphenoxy)pentane­ nitrile A mixture of 1.365 g of 5-(4-acetyl-5-hydroxy-­ 2-allylphenoxy)pentanenitrile, 0.966 g of potassium carbonate, and 1.42 g of methyl iodide in 50 ml of dimethylformamide was stirred together at room tem­ perature for 5 hours. The mixture was partitioned between dilute hydrochloric acid and ethyl acetate. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo to provide 1.2 g of the desired title product, m.p. = 40-42°C. NMR, MS. Example 114 3-[(4-Acetyl-2-ethyl-5-methoxyphenoxy)methyl]­ benzonitrile The title compound was prepared in 30% yield from the compound of Example 55 and methyl iodide according to the procedure of Example 16, m.p. 124-126°C. Analysis for C₁₉H₁₉NO₃: Calculated: C, 73.77; H, 6.19; N, 4.53; Found: C, 73.51; H, 6.22; N, 4.51. Example 115 5-(4-Acetyl-5-methoxy-2-allylphenoxy)pentane­ nitrile The title compound was prepared in 14% yield from the corresponding phenol according to the procedure of Example 111, m.p. = 41-42°C. Analysis for C₁₇H₂₁NO₃: Calculated: C, 71.06; H, 7.37; N, 4.87; Found: C, 70.09; H, 7.17; N, 4.83. Example 116 2-Hydroxy-5-propyl-4-[4-(1-tetrazol-5-yl)-­ butoxy]acetophenone One gram of 2-hydroxy-5-allyl-4-[4-(1H-­ tetrazol-5-yl)butoxy]acetophenone was hydrogenated in the presence of 0.5 g of 5% palladium on carbon in 50 ml of ethanol for 1 hour. The reaction mixture was filtered and concentrated in vacuo . The residue was crystallized from diethyl ether to provide 0.7 g of the desired title product, m.p. = 135-136°C. Analysis for C₁₆H₂₂N₄O₃: Calculated: C, 60.36; H, 6.97; N, 17.60; Found; C, 60.65; H, 7.12; N, 17.46. Examples 117 and 118 The following compounds were prepared according to the procedure of Example 116 from the corresponding allyl derivatives. 117. 6-(4-Acetyl-5-hydroxy-2-propylphenoxy)­ hexanoic acid, 60% yield, m.p. = 90-92°C. Analysis for C₁₇H₂₂O₅: Calculated: C, 66.65; H, 7.24; Found: C, 66.48; H, 7.29. 118. 5-(4-Acetyl-5-hydroxy-2-propylphenoxy)­ pentanenitrile, 77% yield, m.p. = 64-66°C. Analysis for C₁₆H₂₁NO₃: Calculated: C, 69.79; H, 7.69; N, 5.09; Found: C, 70.00; H, 7.56; N, 5.27. Examples 119-120 2-Hydroxy-4-[4-(1-methyl-1H-tetrazol-5-yl)-­ butoxy]-5-allylacetophenone and 2-hydroxy-4-[4-(2-­ methyl-2H-tetrazol-5-yl)butoxy]-5-allylacetophenone A mixture of 632 mg of 2-hydroxy-4-[4-(1H-­ tetrazol-5-yl)butoxy]-5-allylacetophenone, 0.249 ml of methyl iodide, 0.29 g of potassium carbonate and 50 ml of dimethylformamide were allowed to react over­ night. The mixture was then heated to 50°C under a nitrogen atmosphere for 4 hours, cooled, and partitoned between dilute hydrochloric acid and ethyl acetate. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo . The residue was purified by preparative thin layer chromatography over silica gel eluting with 100% ethyl acetate providing 170 mg of the title 1-methyl derivative and 100 mg of the desired 2-methyl compound. 119. 2-Hydroxy-4-[4-(1-methyl-1H-tetrazol-­ 5-yl)butoxy]-5-allylacetophenone, m.p. = 38-40°C. Analysis for C₇H₂₂N₄O₃: Calculated: C, 61.80; H, 6.71; N, 16.74; Found: C, 61.53; H, 6.99; N, 16.74. 120. 2-Hydroxy-4-[4-(2-methyl-2H-tetrazol-­ 5-yl)butoxy]-5-allylacetophenone, m.p. = 80-81°C. Analysis for C₁₇H₂₂N₄O₃: Calculated: C, 61.80; H, 6.71; N, 16.96; Found: C, 62.05; H, 6.97; N, 16.77. Examples 121-125 The following compounds were prepared accord­ ing to the procedure of Examples 119-120 from the corre­ sponding tetrazole derivative. 121. 2-Hydroxy-4-{[3-(2-methyl-2H-tetrazol-­ 5-yl)phenyl}methoxy]-5-allylacetophenone, 10% yield. NMR. 122. 2-Hydroxy-4-[4-(1-methyl-1H-tetrazol-­ 5-yl)butoxy]-5-ethylacetophenone, 38% yield, m.p. = 90-91°C. Analysis for C₁₆H₂₂N₄O₃: Calculated: C, 60.36; H, 6.97; N, 17.60; Found: C, 60.69; H, 7.25; N, 17.27. 123. 2-Hydroxy-4-[4-(2-methyl-2H-tetrazol-­ 5-yl)butoxy]-5-ethylacetophenone, 27% yield, m.p. = 65-66°C. Analysis for C₁₆H₂₂N₄O₃: Calculated: C, 60.36; H, 6.97; N, 17.60; Found: C, 60.53; H, 6.59; N, 17.43. Example 124 5,5′-{[4-Acetyl-6-(hydroxymethyl)-1,3-pheny­ lene]bis(oxy)}bis[pentanenitrile] Two grams of 5,5′-{[4-acetyl-6-formyl-1,3-­ phenylene]bis(oxy)}bis[pentanenitrile] were hydrogenated in the presence of 1 g of 10% palladium on carbon in 400 ml of ethanol. The reaction mixture was filtered, concentrated in vacuo and triturated with diethyl ether to provide 1.6 g of the desired product, m.p. = 98-99°C. Analysis for C₁₉H₂₄N₂O₄: Calculated: C, 66.26; H, 7.02; N, 8.13; Found: C, 65.96; H, 6.76; N, 8.01. Example 125 5-[4-Acetyl-5-hydroxy-2-(2-hydroxypropyl)­ phenoxy]pentanenitrile A. Preparation of 5-[4-acetyl-5-hydroxy-2-(2,3-epoxy­ propyl)phenoxy]pentanenitrile. To a solution of 5.46 g of 5-[4-acetyl-5-­ hydroxy-2-allylphenoxy]pentanenitrile in 100 ml of methylene chloride were added 6.1 g of 85% meta-chloro­ perbenzoic acid. After stirring for 5 hours, the reac­ tion mixture was concentrated in vacuo . The residue was partitioned between ethyl acetate and a cold sodium bicarbonate solution. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo to approximately 35 ml. The solution was placed in a freezer overnight providing 4.08 g of the crystalline title product which were recovered by filtration, m.p. 86-87°C. B. Preparation of 5-[4-acetyl-5-hydroxy-2-(2-hydroxy­ propyl)phenoxy]pentanenitrile. The epoxide intermediate from Example 125A above (0.9 g) was hydrogenated in the presence of 0.5 g of 5% palladium on carbon in 50 ml of ethanol. Filtration of the reaction mixture and crystallization from diethyl ether provided 190 mg of the desired title product, m.p. = 86-88°C. Analysis for C₁₆H₂₁NO₄: Calculated: C, 65.96; H, 7.27; N, 4.81; Found: C, 65.79; H, 4.32; N, 4.56. Example 126 5,5′-{[4-Acetyl-6-(chloromethyl)-1,3-pheny­ lene]bis(oxy)}bis[pentanenitrile] The compound of Example 124 (688 mg) was dis­ solved in 50 ml of dimethylformamide. To this solution were added 0.29 ml of collidine followed by 0.252 g of lithium chloride. The reaction was cooled by means of an external ice bath and 0.507 ml of methane sulfonyl chloride were added. After stirring for 2 hours, the reaction was allowed to warm to room temperature. The mixture was poured into cold dilute hydrochloric acid to which sodium chloride had been added and the solution was extracted with ethyl acetate. The organic layer was washed twice with cold hydrochloric acid/sodium chloride, dried over sodium sulfate, and concentrated in vacuo . Concentration of the solution provided a residue which was crystallized from methylene chloride/hexane to provide 180 mg of the desired title product, m.p. = 100-110°C (decomposition). Analysis for C₁₉H₂₃ClN₂O₃: Calculated: C, 67.02; H, 7.31; N, 7.82; Found: C, 67.02; H, 7.04; N, 7.73. Example 127 7-[4-Acetyl-5-hydroxy-2-(chloromethyl)phenoxy]­ heptanenitrile The title product was prepared in 70% yield from the corresponding hydroxymethyl compound according to the procedure of Example 126. NMR. Example 128 7-[4-Acetyl-5-hydroxy-2-(methylthiomethyl)­ phenoxy]heptanenitrile A mixture of 600 mg of the compound from Example 127 was dissolved in 50 ml of methylene chloride and cooled to 0°C. Fifteen grams of methanethiol were added followed by the addition of 2 ml of triethylamine. The reaction was allowed to warm to room temperature and was stirred overnight. The reaction mixture was concentrated in vacuo and partitioned between ethyl acetate and an acidic sodium chloride solution. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo . The residue was purified by preparative thin layer chromatography over silica gel eluting with 40% ethyl acetate in hexane providing 200 mg of the desired title product, m.p. = 78°C. Analysis for C₁₇H₂₃NO₃S: Calculated: C, 63.52; H, 7.21; N, 4.36; S, 9.98; Found: C, 63.64; H, 6.98; N, 4.60; S, 9.71. Example 129 7-[4-Acetyl-5-hydroxy-2-(methoxymethyl)phenoxy]­ heptanenitrile Approximately 3 millimoles of the chloro com­ pound of Example 127 were treated with 0.624 g of silver perchlorate in 50 ml of methanol at 0°C. The reaction mixture was allowed to warm to room temperature over a 2 hour period. The mixture was then partitioned between ethyl acetate and an acidic sodium chloride solution. The organic layer was separated, dried over sodium sul­ fate, filtered, and concentrated in vacuo . The residue was purified by preparative thin layer chromatography over silica gel eluting with 1:1 ethyl acetate/hexane providing 50 mg of the title compound. NMR, MS. Example 130 5-(4-Benzoyl-2-ethyl-5-hydroxyphenoxy)pentane­ nitrile Following the procedure of Example 16, 0.726 g of 5-ethyl-2,4-dihydroxybenzophenone and 0.53 g of 5-­ bromopentanenitrile were allowed to react and provided 0.37 g of the desired title product, m.p. = 42-44°C. Analysis for C₂₀H₂₁NO₃: Calculated: C, 74.28; H, 6.55; N, 4.33; Found: C, 74.14; H, 6.62; N, 4.51. Example 131 5-(4-Acetyl-5-hydroxy-2-allylphenoxy)pentanoic acid When 2 g of 5-(4-acetyl-5-hydroxy-2-allyl­ phenoxy)pentanenitrile were hydrolyzed following the procedure of Example 84, 1.98 g of the desired title product were recovered, m.p. = 110-111°C. Analysis for C₁₆H₂₀O₅: Calculated: C, 65.97; H, 6.57; Found: C, 65.86; H, 6.81. Example 132 5-(4-Acetyl-5-hydroxy-2-propylphenoxy)pentanoic acid The compound of Example 131 (1.46 g) was added to 150 ml of ethanol and hydrogenated in the presence of 1.5 g of 5% palladium on carbon. After the theo­ retical amount of hydrogen was taken up, the reaction was discontinued, the reaction mixture was filtered. The filtrate was concentrated in vacuo and provided 1.49 g of the desired title product,. m.p. = 106°C. Analysis for C₁₆H₂₂O₅: Calculated: C, 65.51; H, 7.22; Found: C, 66.77; H, 8.12. Example 133 5-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-­ dimethylpentanenitrile Following the procedure of Example 68, 4.52 g of 4-(3-bromopropoxy)-5-ethyl-2-hydroxyacetophenone and 1.36 ml of isobutyronitrile were reacted to provide 1.72 g of the desired title compound, m.p. = 55-56°C. Analysis for C₁₇H₂₃NO₃: Calculated: C, 70.56; H, 8.01; N, 4.84; Found: C, 69.19; H, 8.05; N, 4.33. Examples 134-135 5-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-­ dimethylpentanoic acid and 5-(4-acetyl-2-ethyl-5-­ hydroxyphenoxy)-2,2-dimethylpentanamide Following the procedure of Example 84, 114 mg of the nitrile of Example 133, 15 ml of 5N sodium hydroxide, and 50 ml of ethanol were heated at reflux for 24 hours. After workup, purification by preparative thin layer chromatography over silica gel provided 11 mg of the title amide and 13 mg of the title acid. 134. 5-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-­ 2,2-dimethylpentanoic acid, m.p. = 128-131°C. Analysis for C₁₇H₂₄O₅: Calculated: . C. 66.21; H, 7.85; N, 0; Found: C, 63.14; H, 7.55; N, 0.60. 135. 5-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-­ 2,2-dimethylpentamide, m.p. = 104-105°C. Analysis for C₁₇H₂₅NO₄: Calculated: C, 66.43; H, 8.20; N, 4.56; Found: C, 65.76; H, 8.57; N, 3.97. Example 136 1-(5-Ethyl-2-hydroxy-4-{[4-methyl-4-(1H-­ tetrazol-5-yl)pentyl]oxy}phenyl)ethanone The title tetrazole was prepared in 48% yield from the nitrile from Example 133 according to the procedure provided in Example 108, m.p. = 156-157°C. Analysis for C₁₇H₂₄N₄O₃: Calculated: C, 61.43; H, 7.28; N, 16.86; Found: C, 61.60; H, 7.02; N, 16.80. Example 137 1-{4-[(5-Aminopentyl)oxy]-5-ethyl-2-hydroxy­ phenyl}ethanone A mixture of 2.0 g of 5-(4-acetyl-2-ethyl-5-­ hydroxyphenoxy)pentanenitrile, 50 ml of acetic acid, and 2.0 g of 10% palladium on carbon were subjected to hydrogenation for approximately 2 hours. The mixture was then filtered and concentrated in vacuo . The residue was triturated with diethyl ether to provide 2 g of the desired title product, m.p. = 75-76°C. NMR. Example 138 N-[5-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ pentyl]acetamide In a manner analogous to that taught in Example 77, 265 mg of the amine from Example 137 was acylated with acetyl chloride and pyridine to provide 158 mg of the desired title product, m.p. = 115-116°C. Analysis for C₁₇H₂₅NO₄: Calculated: C, 66.43; H, 8.20; N, 4.56; Found: C, 66.24; H, 8.29; N, 4.47. Example 139 5-(4-Acetyl-5-hydroxy-2-allylphenoxy)pentane­ nitrile The title product was prepared in 88% yield from 5-allyl-2,4-dihydroxyacetophenone and 5-bromo­ pentanenitrile following the procedure of Example 16, m.p. = 54°C. Analysis for C₁₆H₁₉NO₃: Calculated: C, 70.31; H, 7.01; N, 5.12; Found: C, 69.38; H, 7.54; N, 4.80. Example 140 1-(5-Ethyl-2-hydroxy-4-{[6-(1H-tetrazol-5-yl)-­ hexyl]oxy}phenyl)ethanone The title compound was prepared in 63% yield from the nitrile of Example 20 following the procedure of Example 108, m.p. = 126-127°C. Analysis for C₁₇H₂₄N₄O₃: Calculated: C, 61.43; H, 7.28; N, 16.86; Found: C, 61.47; H, 7.11; N, 16.88. Examples 141-142 5-[4-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ butyl]-2H-tetrazole-2-acetic acid, ethyl ester and 5-[4-(4-acetyl-2-ethyl-5-hydroxyphenoxy)butyl]-1H-­ tetrazole-1-acetic acid, ethyl ester The title products were prepared by the method provided in Examples 119-120 employing 2-hydroxy-4-­ [4-(1H-tetrazol-5-yl)butoxy]-5-ethylacetophenone and ethyl bromoacetate. 141. 5-[4-(4-Acetyl-2-ethyl.-5-hydroxy­ phenoxy)butyl]-2H-tetrazole-2-acetic acid, ethyl ester, 29% yield, m.p. = 118-121°C. Analysis for C₁₉H₂₆N₄O₅: Calculated: C, 58.44; H, 6.71; N, 14.35; Found: C, 58.15; H, 6.56; N, 14.52. 142. 5-[4-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ butyl]-1H-tetrazole-1-acetic acid, ethyl ester, 18% yield, m.p. = 86-87°C. Analysis for C₁₉H₂₆N₄O₅: Calculated: C, 58.44; H, 6.71; Found: C, 58.66; H, 6.89. Examples 143-144 The following acid derivatives were prepared from the corresponding esters of Examples 141-142 upon hydrolysis in aqueous ethanol with potassium hydroxide. 143. 5-[4-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ butyl]-2H-tetrazole-2-acetic acid, 80% yield, m.p. >230°C. NMR, MS. 144. 5-[4-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ butyl]-1H-tetrazole-1-acetic acid, 80% yield, m.p. = 161-162°C. Analysis for C₁₇H₂₂N₄O₅: Calculated: C, 56.35; H, 6.12; N, 15.46; Found: C, 56.62; H, 6.30; N, 15.25. Example 145 7-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-N-1H-­ tetrazol-5-ylheptanamide The acid chloride of 616 mg of 7-(4-acetyl­ 5-hydroxy-2-ethylphenoxy)heptanoic acid was prepared according to the procedure of Example 95. To the acid chloride were added 2.06 g of 5-aminotetrazole hydrate, 16.4 g of sodium bicarbonate, and 100 ml of acetone. The reaction was stirred for 2 days. The solvent was removed in vacuo and the residue was partitioned between ethyl acetate and water. The water layer was separated and acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was separated, dried over sodium sulfate, filtered, and concentrated in vacuo . Crystallization of the residue from methanol/water provided 76 mg of the desired product, m.p. = 196-200°C. Analysis for C₁₈H₂₅N₅O₄: Calculated: C, 57.59; H, 6.71; N, 18.65; Found: C, 57.42; H, 6.60; N, 18.38. Example 146 1-(5-Ethyl-2-hydroxy-4-{[5-(1H-1,2,4-triazol-­ 1-yl)pentyl]oxy}phenyl)ethanone A mixture of 0.3 g of 5-(4-acetyl-2-ethyl-5-­ hydroxyphenoxy)pentyl bromide, 0.06 g of triazole, and 0.13 g of potassium carbonate in dimethylformamide was heated at 80-90°C for approximately 18 hours. The mixture was poured into acidic water and extracted with ethyl acetate and methylene chloride. The extracts were combined, washed with dilute sodium hydroxide solution, dried over sodium sulfate, and concentrated in vacuo . The residue was twice crystallized from ethyl acetate/hexane to provide the title product having a melting point of 87°C. Analysis for C₁₇H₂₃N₃O₃: Calculated: C, 64.33; H, 7.30; N, 13.24; Found: C, 64.07; H, 7.23; N, 13.06. Example 147 4-[(4-Acetyl-2-ethyl-5-hydroxyphenoxy)methyl]-­ 2-hydroxybenzoic acid, ethyl ester A mixture of 0.75 g of 2,4-dihydroxy-5-ethyl­ acetophenone, 1.23 g of ethyl 2-acetoxy-4-bromomethyl­ benzoate, 0.57 g of potassium carbonate, and a catalytic amount of potassium iodide were heated at reflux in methyl ethyl ketone overnight. The hot mixture was filtered and the filtrate concentrated to dryness. Crystallization of the residue from ethyl acetate/hexane provided. 130 mg of the desired title product, m.p. 145-146°C. Analysis for C₂₀H₂₂O₆: Calculated: C, 67.02; H, 6.18; Found: C, 68.16; H, 6.15. Example 148 4-[(4-Acetyl-2-ethyl-5-hydroxyphenoxy)methyl]-­ 2-hydroxybenzoic acid The title product was prepared in 69% yield from the corresponding ethyl ester upon heating with potassium hydroxide in aqueous ethanol, m.p. 214-216°C. Analysis for C₁₈H₁₈O₆: Calculated: C, 65.45; H, 5.49; Found: C, 65.67; H, 5.60. The compounds of this invention have demon­ strated activity in vivo in various test systems designed to detect effective antiinflammatory agents. These pharmacodynamic effects were demonstrated in the following test systems. Carrageenin Assay The compounds were evaluated for antiinflam­ matory activity in the test method described by C.A. Winter, Proc. Soc. Exp. Biol. Med. , 111 , 544 (1962). In this test, inflammation is created by injecting car­ rageenin into the hind paws of rats. Test compounds are administered prior to injection to determine percent inhibition of the subsequent inflammation in comparison with control animals. The results are reported in Table I. Arachidonic Acid-Induced Ear Edema Assay Female BALB/C mice (Charles River; 18-20 grams) were divided into groups of five. Arachidonic acid was dissolved in ethanol at a concentration of 200 mg/ml. Each mouse received 2 mg/ear of arachidonic acid on the inner surface of the right ear. This dose of phlogistic was applied by an automatic pipette in 10 mcl volumes. The left ear (control) received ethanol. Drugs were applied topically in an ethanol-­ based gel to the entire outer surface of both ears one hour prior to arachidonic acid application. Edema was measured by the increase in ear weight. An hour after arachidonic acid solution or vehicle was applied, an ear sample of 7 mm in diameter was obtained from both ears. Ear edema was calculated by subtracting the weight of the right ear sample (treated ear) from left ear (control), dividing by the weight of the left/control ear, and averaging the results for each group of mice according to compound and concentration. The results are reported below in Table II. Anti IL-1 Activity (Thymocyte Assay) Thymus from 3-4 week old C3H/HeJ male mice and were passed through a #100 mesh screen to make a single cell suspension. The cells were suspended in RPMI-1640 supplemented with 2 × 10⁻⁵M 2-mercaptoethanol, 3% fetal calf serum, and 1% Penicillin/Streptomycin. The cell suspension was placed in a tissue culture flask and incubated at 37°C in 5% carbon dioxide in air for 1-2 hours. The thymocytes were decanted, leaving adherent cells behind, and the liquid was centrifuged at 1400 rpm for 10 minutes. After decanting the supernatant, the cells were resuspended and counted with a hemocytometer. The density was adjusted to 2 × 10⁷ cells/ml. Fifty µl of the suspension were added to each well of a 96-well microtiter plate, followed by the addition of 25 µl of PHA and 25 µl IL-1 (1:25 dilution of a 10 mcg/ml stock solution) per well. Each compound to be tested was dissolved in 30% DMSO/70% PBS to make a stock solution of 1 mg/ml. Fifteen µl of each compound were added to 300 µl of media in the serial dilution plate. Twenty-five µl of each drug were added to the test plate in quadruplicate wells accross the plate. The plate was incubated at 37°C in 5% carbon dioxide in air for 48 hours. The wells were pulsed with tritiated thymidine (5 µCi/well) for 4 hours before harvesting on a Skatron cell harvester. The filter discs were placed in mini-vials, scintil­ lation fluid (Tol-Pop) was added, and the vials counted. The percent of counts for each vial compared with control samples wherein no compound was added (vehicles only) was determined for each compound and are reported as Table III below as the percent T-cell suppression. Mouse Endotoxin Shock Assay Compounds were given to 18-20 g C57BL/6 male mice using various regimens depending upon mode of administration. Control animals received corresponding vehicles only. The mice were then challenged with 0.2 ml of chromatographically purified 0111:B4 E . coli LPS and galactosamine hydrochloride (GALN) given sub­ cutaneously (back of the neck). GALN was given at an approximate dose of 500 mg/kg whereas the LPS dose ranged between 0.3-1.2 µg/mouse (15-60 µg/kg). Control animals generally die of shock 7-15 hours after admin­ istration of LPS/GALN although a small number (0-5%) may die 24-48 hours after such administration. Calculation of the ED₅₀ for each compound was performed using the Reed Muench Method for results obtained 48 hours after challenge. Results are summarized in Table IV below. The compounds of Formula I should be useful in treating any condition, including clinical conditions, which is characterized by the excessive release of leukotriene B₄. These conditions include psoriasis, arthritis, chronic lung diseases, inflammatory bowel disease, and other inflammatory states characterized by the infiltration and aggregation of polymorphonuclear leukocytes. The term "excessive release" of leukotriene B₄ refers to an amount of leukotriene sufficient to cause the particular condition associated with such amount. The amount of LTB₄ which is considered to be excessive will depend on a variety of factors, including the amount of leukotriene required to cause the particular condition, and the species of the mammal involved. As will be appreciated by those skilled in the art, the success of treating a mammal suffering from or sus­ ceptible to a condition characterized by an excessive release of leukotriene B₄ with a compound of formula I will be measured by the regression or prevention of the symptoms of the condition. Leukotriene B₄ antagonism was demonstrated by the following test procedure: Inhibition of Binding of ³H-LTB₄ to Peripheral Human Neutrophils The effectiveness of compounds to inhibit the binding of leukotriene B₄ to a specific receptor on the membrane of human neutrophils was measured by using an adaptation of a radio-ligand binding assay developed by Goldman and Goetzl, J. Immunol ., 129 1600 (1982). Other investigators have developed similar assays (see, e.g., Kreisle, et al ., J. Exp. Med. , 157 , 628 (1983) and Lin, et al ., Prostaglandins , 28 837 (1984)). Cells used in the assay were isolated by standard techniques of centrifugation on Ficoll-Hypaque, dextran 70 sedimentation and hypotonic lysis. The following procedure was used. Freshly-prepared buffy coat layers from two individuals were obtained from a local blood donor center. The cells were mixed and diluted to 484 ml. with phosphate buffered saline con­ taining heparin (10 units/ml) and heat-inactivated calf serum (5%). This was divided into 20 ml. aliquots and the aliquots layered on top of Ficoll-Paque (12 ml.). The material was then centrifuged at 500 g. for 40 minutes at room temperature. The resulting upper layer of platelets and mononuclear cells was discarded. The lower layer containing erythrocytes and neutrophils was retained. Buffer was added (1 ml. per 4 ml. of lower layer) and the suspension mixed. For each milliliter of this mixture, 0.33 ml. of 6% Macrodex was added. After stirring, the cells were allowed to sediment for 1 hour at 37°C. The resulting erythrocyte pellet was dis­ carded and the neutrophil enriched supernatant fluid centrifuged at 500 g. for 10 minutes at 4°C. Erythro­ cytes still present in this cell pellet were lysed by incubating the cells with 5-8 ml. ice-cold distilled water for 30-45 seconds. Subsequently, the volume was made up to 50 ml. by addition of ice-cold buffer and the cells resuspended. The suspension was then centrifuged at 300 g. for 10 minutes at 4°C. The cells were finally resuspended at a cell density of 2 × 10⁷ cells/ml in the assay buffer. This buffer consisted of Hanks' balanced salt solution and 0.1% ovalbumin (pH 7.3). This isolation procedure resulted in cell preparations of ≧90% neutrophils and ≧90% viability. The radio-ligand binding assay was conducted by incubating neutrophils (1 × 10⁷ cells) with 0.1-0.2 nM ³H-LTB₄ (sp. act. 150-220 Curies/mmol) and test compound (1 × 10⁻⁵M and 1 × 10⁻⁶M) for 10 minutes at 4°C. The amount of bound ³H-LTB₄ was then measured and compared with the amount bound in the absence of test compound. The assay was carried out in microcentrifuge tubes by adding first 10 µl test compound dissolved in DMSO, followed by adding 20 µl ³H-LTB₄ diluted in assay buffer, and finally adding 500 µl of the cell sus­ pension. At the end of the 10 minutes incubation, 300 µl of a mixture of dibutyl and dinonyl phthalate (7:2) were added and the tubes centrifuged for 2 minutes in a microcentrifuge. The radioactivity bound to the cell pellet was measured by scintillation spectroscopy. Appropriate corrections for nonspecific bonding of ³H-LTB₄ were made. The results are reported in Table V. The compounds or formulations of the present invention may be administered by the oral and rectal routes, topically, parenterally, e.g. , by injection and by continuous or discontinuous intra-arterial infusion, in the form of, for example, tablets, lozenges, sublin­ gual tablets, sachets, cachets, elixirs, gels, suspen­ sions, aerosols, ointments, for example, containing from 1 to 10% by weight of the active compound in a suitable base, soft and hard gelatin capsules, suppositories, injectable solutions and suspensions in physiologically acceptable media, and sterile packaged powders adsorbed onto a support material for making injectable solutions. Advantageously for this purpose, compositions may be provided in dosage unit form, preferably each dosage unit containing from about 5 to about 500 mg. (from about 5 to 50 mg. in the case of parenteral or inhala­ tion administration, and from about 25 to 500 mg. in the case of oral or rectal administration) of a compound of Formula I. Dosages of from about 0.5 to about 300 mg./kg. per day, preferably 0.5 to 20 mg./kg., of active ingredient may be administered although it will, of course, readily be understood that the amount of the compound or compounds of Formula I actually to be administered will be determined by a physician, in the light of all the relevant circumstances including the condition to be treated, the choice of compound to be administered and the choice of route of administration and therefore the above preferred dosage range is not intended to limit the scope of the present invention in any way. The formulations of the present invention normally will consist of at least one compound of Formula I mixed with a carrier, or diluted by a carrier, or enclosed or encapsulated by an ingestible carrier in the form of a capsule, sachet, cachet, paper or other container or by a disposable container such as an ampoule. A carrier or diluent may be a solid, semi-­ solid or liquid material which serves as a vehicle, excipient or medium for the active therapeutic substance. Some examples of the diluents or carrier which may be employed in the pharmaceutical compositions of the present invention are lactose, dextrose, sucrose, sorbitol, mannitol, propylene glycol, liquid paraffin, white soft paraffin, kaolin, fumed silicon dioxide, microcrystalline cellulose, calcium silicate, silica, polyvinylpyrrolidone, cetostearyl alcohol, starch, modified starches, gum acacia, calcium phosphate, cocoa butter, ethoxylated esters, oil of theobroma, arachis oil, alginates, tragacanth, gelatin, syrup, methyl cellulose, polyoxyethylene sorbitan monolaurate, ethyl lactate, methyl and propyl hydroxybenzoate, sorbitan trioleate, sorbitan sesquioleate and oleyl alcohol and propellants such as trichloromonofluoromethane, dichloro­ difluoromethane and dichlorotetrafluoroethane. In the case of tablets, a lubricant may be incorporated to prevent sticking and binding of the powdered ingredients in the dies and on the punch of the tableting machine. For such purpose there may be employed for instance aluminum, magnesium or calcium stearates, talc or mineral oil. Preferred pharmaceutical forms of the present invention are capsules, tablets, suppositories, inject­ able solutions, creams and ointments. Especially preferred are formulations for inhalation application, such as an aerosol, topical formulations, and those for oral ingestion. The following formulation examples may employ as active compounds any of the compounds of this inven­ tion. The examples are illustrative only and are not intended to limit the scope of the invention in any way. Example 149 Hard gelatin capsules are prepared using the following ingredients: The above ingredients are mixed and filled into hard gelatin capsules in 460 mg. quantities. Example 150 A tablet is prepared using the ingredients below: The components are blended and compressed to form tab­ lets each weighing 665 mg. Example 151 An aerosol solution is prepared containing the following components: The active compound is dissolved in the ethanol and the solution is added to the propellant 11, cooled to -30°C. and transferred to a filling device. The required amount is then fed to a container and further filled with the pre-mixed propellants 12 and 114 by means of the cold-filled method or pressure-­ filled method. The valve units are then fitted to the container. Example 152 Tablets each containing 60 mg. of active in­ gredient are made up as follows: The active ingredient, starch and cellulose are passed through a No. 45 mesh U.S. sieve and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders which are then passed through a No. 14 mesh U.S. sieve. The granules so pro­ duced are dried at 50-60°C. and passed through a No. 18 mesh U.S. sieve. The sodium carboxymethyl starch, mag­ nesium stearate and talc, previously passed through a No. 60 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 150 mg. Example 153 Capsules each containing 80 mg. of medicament are made as follows: The active ingredient, cellulose, starch and magnesium stearate are blended, passed through a No. 45 mesh U.S. sieve, and filled into hard gelatin capsules in 200 mg. quantities. Example 154 Suppositories each containing 225 mg of active ingredient are made as follows: 5-[4-(4-Acetyl-2-ethyl-5-hydroxy­ phenoxy)butyl]-2H-tetrazole-­ 2-acetic acid, sodium salt 225 mg. Unsaturated or saturated fatty acid glycerides to 2,000 mg. The active ingredient is passed through a No. 60 mesh U.S. sieve and suspended in the fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a supposi­ tory mold of nominal 2 g. capacity and allowed to cool. Example 155 Suspensions each containing 50 mg. of medic­ ament per 5 ml. dose are made as follows: 5-(4-Acetyl-5-hydroxy-2-allyl­ phenoxy)pentanenitrile 50 mg Sodium carboxymethyl cellulose 50 mg Sugar 1 g Methyl paraben 0.05 mg Propyl paraben 0.03 mg Flavor q.v. Color q.v. Purified water to 5 ml The medicament is passed through a No. 45 mesh U.S. sieve and mixed with the sodium carboxymethyl­ cellulose, sugar, and a portion of the water to form a suspension. The parabens, flavor and color are dis­ solved and diluted with some of the water and added, with stirring. Sufficient water is then added to produce the required volume.

Claims: 1. A compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R₁ is hydrogen or R′OOC-; Z is -(CH₂)n- or phenylene; n is 1-8; R₂ is hydroxy, halo, or -O-(CH₂)m-Y; R₃ is C₁-C₆ alkyl, C₁-C₆ alkanoyl, C₂-C₄ alkenyl, C₁-C₄ alkoxy, hydroxy-substituted C₁-C₃ alkyl, or -CH₂-D; A is a bond or straight or branched chain C₁-C₁₀ alkylidene; R₄ is C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, hydroxy, -CN, halo, -N₃, -NR₅R₆, -COR₇, -S(O)p-(C₁-C₄ alkyl), 1,2,4-triazol-1-yl, 5-tetrazolyl optionally substituted with a C₁-C₄ alkyl group or -(CH₂)qCOOR′, or phenyl optionally substituted with one or two groups selected from halo, cyano, C₁-C₃ alkyl, trifluoromethyl, -CH₂CN, -CH₂Br, C₁-C₄ alkoxy, -S(O)p-(C₁-C₄ alkyl), acetenyl, -COOR′, 5-­ tetrazolyl, or 5-tetrazolyl substituted with C₁-C₄ alkyl or -(CH₂)q-COOR′ where each R′ is independently hydrogen or C₁-C₄ alkyl; m is 1-4; q is 1-4; Y is hydrogen or -CN; D is halo, C₁-C₄ alkoxy, or -S-(C₁-C₄ alkyl); R₅ and R₆ are independently hydrogen, C₁-C₃ alkyl, or C₂-C₄ alkanoyl, or when taken together with the nitrogen atom to which they are attached form a morpholino ring; R₇ is hydroxy, C₁-C₄ alkoxy, halo, -NR₅R₆, -NHOH, or C₁-C₃ alkyl; and each p is 0, 1, or 2, provided that when A is a bond, R₄ must be C₁-C₆ alkyl or an optionally substituted phenyl group, and further provided that when one of R₅ and R₆ is C₂-C₄ alkanoyl, the other of R₅ and R₆ is hydrogen. 2. A compound as claimed in claim 1 of the Formula Ia or a pharmaceutically acceptable salt thereof, wherein R₁′ is methyl or ethyl; R₂′ is hydrogen or methyl; R₃′ is ethyl, propyl, -CH₂-S-CH₃, or allyl; and R₄′ is hydroxy, cyano, -COOR′, -CONR₅R₆, -CO(C₁-C₃ alkyl), -S(O)p-(C₁-C₄ alkyl), 5-tetrazolyl optionally substituted with a C₁-C₄ alkyl group, or phenyl optionally substituted in the meta position with halo, cyano, C₁-C₃ alkyl, trifluoromethyl, -CH₂CN, -CH₂Br, C₁-C₄ alkoxy, -S(O)p-(C₁-C₄ alkyl), acetyl, or -COOR′. 3. A compound of Formula Ia as claimed in claim 2, wherein the compound is 2-hydroxy-4-[4-(2-­ methyl-2H-tetrazol-5-yl)butoxy]-5-ethylacetophenone, 2-hydroxy-4-[6-(methylsulfonyl)hexyloxy]-5-ethylaceto­ phenone, or 7-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-­ dimethylheptanoic acid or a pharmaceutically acceptable salt thereof. 4. 3-[(4-Acetyl-2-ethyl-5-hydroxyphenoxy)­ methyl]benzonitrile. 5. 5-Ethyl-2-hydroxy-4-[6-methyl-6-(1H-­ tetrazol-5-yl)heptyloxy]acetophenone or a pharmaceuti­ cally acceptable salt thereof. 6. A pharmaceutical composition which com­ prises a compound as claimed in any one of the claims 1 to 5, or a pharmaceutically-acceptable salt thereof, associated with one or more pharmaceutically-acceptable carriers or excipients therefor. 7. A compound of Formula I, as claimed in any one of claims 1 to 5, or a pharmaceutically-acceptable salt thereof, for use in the treatment of inflammation. 8. A process for preparing a compound of Formula I as claimed in any one of claims 1 to 5 which comprises: (a) acylating a compound of the formula wherein R₂, R₃, R₄ and A are as defined for Formula I, under Friedel-Crafts conditions so as to produce a compound of the Formula I (b) alkylating a phenol of the formula wherein R₁, R₂, R₃ and Z are as defined in claim 1, in the presence of a base strong enough to generate the anion of the phenol; or (c) reacting a compound of claim 1 wherein R₁, Z, R₂, R₃, and A are as defined in claim 1 and R₄ is a group of the formula: with an azide reagent to give a compound of claim 1 wherein R₄ is a group of the formula d) hydrolyzing a compound of claim 1 wherein R₄ is a group of the formula: i) -CN; or to give a compound of claim 1 wherein R₄ is a group of the formula i) -COOH; or e) hydrolyzing with aqueous base a compound of claim 1 wherein R₁, Z, R₂, R₃, and A are as defined in claim 1 and R₄ is a group of the formula: i) -CN; to give a compound of Formula I in claim 1 wherein R₄ is a primary amide group of the formula i) --NH₂; f) alkylating a compound of claim 1 wherein R₁, Z, R₂, R₃, and A are as defined for claim 1 and R₄ is a 5-tetrazolyl or a phenyl group substituted with one or two (5-tetrazolyl) groups; with an alkylating agent of the formula: X-(CH₂)q-J wherein X is a good leaving group such as a halo group and J is a hydrogen atom or a group of the formula -COOR″, wherein R″ is a C₁ to C₄ alkyl group, in the presence of an acid scavenger, to produce a compound of claim 1 wherein R₄ is a group of the formula wherein q is the same as defined for claim 1, and j is one or two; or g) oxidizing a compound of claim 1 wherein R₁, R₂, R₃, Z, and A are the same as claim 1 and R₄ is a group of the formula to give a compound of claim 1 wherein R₄ is a group of the formula i) -S(O)p-(C₁ to C₄ alkyl); or wherein j is one or two and p is one or two; or h) reducing compounds of claim 1, wherein R₁, Z, R₂, R₃ and A are the same as claim 1 and R₄ is an azide group, to give the corresponding compounds of claim 1 wherein R₄ is a primary amino group; i) acylating compounds of claim 1, wherein R₁, Z, R₂, R₃, and A are the same as for claim 1 and R₄ is a primary amino group or a primary amido group, with an acylating agent of the formula CH₃(CH₂)nCO-LG wherein n is 1 to 3 and "LG" is chloro, bromo or iodo or a group forming an acid anhydride, in the presence of an acid scavenger, to give a compound of claim 1 wherein R₄ is a C₂ to C₄ alkanoylamino group or an N-(C₂ to C₄ alkanoyl)amido group, respectively; j) de-esterifying compound of claim 1 wherein R₁, Z, R₂, R₃, and A are the same as claim 1 and R₄ is a group of the formula i) -COR₇, wherein R₇ is C₁ to C₄ alkoxy; wherein q is the same as claim 1. and R″ is C₁ to C₄ alkyl; wherein R″ is C₁ to C₄ alkyl and (j) is one or two; or wherein (j) is one or two, q is as defined for claim 1 and R″ is C₁ to C₄ alkyl; to give compounds of claim 1 wherein R₄ is a group of the formula: i) -COOH; k) esterifying a compound of claim 1 wherein R₁, Z, R₂, R₃, and A are the same as claim 1 and R₄ is a group of the formula i) -COOH; by reacting a compound of the formula X-(CH₂)d-CH₃ wherein X is a good leaving group and d is one to three so as to form a compound of claim 1 wherein R₄ is a group of the formula: i) -COR₇, wherein R₇ is C₁ to C₄ alkoxy; wherein q is the same as in claim 1 and R″ is C₁ to C₄ alkyl; wherein R″ is C₁ to C₄ alkyl and (j) is one or two; or wherein (j) is one or two, q is as defined for claim 1 and R″ is C₁ to C₄ alkyl; l) demethylating a compound of claim 1 wherein R₁, Z, R₃, A, and R₄ are as described for claim 1 and R₂ is a group of the formula -O-(CH₂)m-Y wherein m is one and y is a hydrogen atom under standard demethylating conditions to give a compound of claim 1 wherein R₂ is a hydroxy group; or m) reacting a compound of claim 1 wherein R₁, R₂, R₃, Z, and A are as defined for claim 1 and R₄ is a group of the formula -COR₇, wherein R₇ is a hydroxy group, with a halogenating reagent such as POCl₃, POBr₃, PCl₅, PBr₅, SOCl₂, (O)₃PCH₃I, and the like to give a compound of claim 1 wherein R₄ is a group of the formula -COR₇ wherein R₇ is a halo group; n) reacting a compound of claim 1, wherein R₁, Z, R₂, R₃, Z and A are as defined for claim 1 and wherein R₄ is halo, with: i) an alkali metal cyanide to produce a compound of claim 1 wherein R₄ is cyano; ii) a primary or secondary amine of the formula HNR₅R₆ to produce a compound of the claim 1 wherein R₄ is a group of the formula -NR₅R₆; or iv) a thiolate anion or thiol of the formula T-S(O)p-(C₁ to C₄ alkyl) wherein T is a hydrogen atom or an alkali metal atom, to produce a compound of claim 1 wherein R₄ is a group of the formula -S(O)p-(C₁ to C₄ alkyl) wherein p is zero; or o) reacting a compound of claim 1 wherein R₁, Z, R₂, R₃, and A, are the same as claim 1 and R₄ is a group of the formula -COR₇, wherein R₇ is a halo group, with: i) an amine of the formula HNR₅R₆ wherein R₅ and R₆ are as defined for claim 1, to produce a com­ pound wherein R₇ is NR₅R₆; or ii) hydroxylamine to produce a compound of claim 1 wherein R₇ is a group of the formula -NHOH; or iii) 5-aminotetrazole to produce a com­ pound of claim 1 wherein R₇ is a 5-aminotetrazole bonded to the acyl group through the amino group nitrogen; or iv) with a C₁ to C₄ alkanol or C₁ to C₄ alkoxide to produce a compound of claim 1 wherein R₇ is C₁ to C₄ alkoxy. 9. A process for producing the compound in claim 5, which comprises: a) alkylating a diphenol of the formula: with 1,5-dibromopentane to produce a compound of the formula: b) alkylating the compound of Formula VI with sodium 2-cyanopropan-2-ate to produce a cyano compound of the formula c) reacting the cyano compound of Formula VII with an azide reagent such as tri(n-butyl)tin azide to give a tetrazole compound of the formula 10. A compound of Formula I as claimed in claim 1 wherein R₁ is hydrogen, Z is a group of the formula -(CH₂)n- wherein n is 1, R₂ is hydroxy, A is a group of the formula: -(CH₂)₂-C(CH₃)₂- and R₄ is a cyano group. Claims for the following Contracting States : GR ; ES 1. A process for preparing a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R₁ is hydrogen or R′OOC-; Z is -(CH₂)n- or phenylene; n is 1-8; R₂ is hydroxy, halo, or -O-(CH₂)m-Y; R₃ is C₁-C₆ alkyl, C₁-C₆ alkanoyl, C₂-C₄ alkenyl, C₁-C₄ alkoxy, hydroxy-substituted C₁-C₃ alkyl, or -CH₂-D; A is a bond or straight or branched chain C₁-C₁₀ alkylidene; R₄ is C₁-C₆ alkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, hydroxy, -CN, halo, -N₃, -NR₅R₆, -COR₇, -S(O)p-(C₁-C₄ alkyl), 1,2,4-triazol-1-yl, 5-tetrazolyl optionally substituted with a C₁-C₄ alkyl group or -(CH₂)qCOOR′, or phenyl optionally substituted with one or two groups selected from halo, cyano, C₁-C₃ alkyl, trifluoromethyl, -CH₂CN, -CH₂Br, C₁-C₄ alkoxy, -S(O)p-(C₁-C₄ alkyl), acetenyl, -COOR′, 5-­ tetrazolyl, or 5-tetrazolyl substituted with C₁-C₄ alkyl or -(CH₂)q-COOR′; where each R′ is independently hydrogen or C₁-C₄ alkyl; m is 1-4; q is 1-4; Y is hydrogen or -CN; D is halo, C₁-C₄ alkoxy, or -S-(C₁-C₄ alkyl); R₅ and R₆ are independently hydrogen, C₁-C₃ alkyl, or C₂-C₄ alkanoyl, or when taken together with the nitrogen atom to which they are attached form a morpholino ring; R₇ is hydroxy, C₁-C₄ alkoxy, halo, -NR₅R₆, -NHOH, or C₁-C₃ alkyl; and each p is 0, 1, or 2, provided that when A is a bond, R₄ must be C₁-C₆ alkyl or an optionally substituted phenyl group, and further provided that when one of R₅ and R₆ is C₂-C₄ alkanoyl, the other of R₅ and R₆ is hydrogen. which comprises: (a) acylating a compound of the formula wherein R₂, R₃, R₄ and A are as defined for Formula I, under Friedel-Crafts conditions so as to produce a compound of the Formula I (b) alkylating a phenol of the formula wherein R₁, R₂, R₃ and Z are as defined above, in the presence of a base strong enough to generate the anion of the phenol; or (c) reacting a compound of Formula I wherein R₁, Z, R₂, R₃, and A are as defined above and R₄ is a group of the formula: i) -CN; or with an azide reagent to give a compound of Formula I wherein R₄ is a group of the formula d) hydrolyzing a compound of Formula I wherein R₄ is a group of the formula: i) -CN; or to give a compound of Formula I wherein R₄ is a group of the formula i) -COOH; or e) hydrolyzing with aqueous base a compound of Formula I wherein R₁, Z, R₂, R₃, and A are as defined in Formula I and R₄ is a group of the formula: i) -CN; to give a compound of Formula I wherein R₄ is a primary amide group of the formula i) --NH₂; f) alkylating a compound of Formula I wherein R₁, Z, R₂, R₃, and A are as defined above and R₄ is a 5-tetrazolyl or a phenyl group substituted with one or two (5-tetrazolyl) groups; with an alkylating agent of the formula: X-(CH₂)q-J wherein X is a good leaving group such as a halo group and J is a hydrogen atom or a group of the formula -COOR″, wherein R″ is a C₁ to C₄ alkyl group, in the presence of an acid scavenger, to produce a compound of Formula I wherein R₄ is a group of the formula wherein q is the same as defined above, and j is one or two; or g) oxidizing a compound of Formula I wherein R₁, R₂, R₃, Z, and A are as defined above and R₄ is a group of the formula to give a compound of Formula I wherein R₄ is a group of the formula wherein j is one or two and p is one or two; or h) reducing a compound of Formula I, wherein R₁, Z, R₂, R₃ and A are as defined above and R₄ is an azide group, to give the corresponding compounds wherein R₄ is a primary amino group; i) acylating compounds of Formula I, wherein R₁, Z, R₂, R₃, and A are as defined above and R₄ is a primary amino group or a primary amido group, with an acylating agent of the formula CH₃(CH₂)nCO-LG wherein n is 1 to 3 and "LG" is chloro, bromo or iodo or a group forming an acid anhydride, in the presence of an acid scavenger, to give a compound of Formula I wherein R₄ is a C₂ to C₄ alkanoylamino group or an N-(C₂ to C₄ alkanoyl)amido group, respectively; j) de-esterifying a compound of Formula I wherein R₁, Z, R₂, R₃, and A are as defined above and R₄ is a group of the formula i) -COR₇, wherein R₇ is C₁ to C₄ alkoxy; wherein q is as defined above and R″ is C₁ to C₄ alkyl; wherein R″ is C₁ to C₄ alkyl and (j) is one or two; or wherein (j) is one or two, q is as defined above and R″ is C₁ to C₄ alkyl; to give compounds of Formula I wherein R₄ is a group of the formula: i) -COOH; wherein q is one to four and (j) is one or two; k) esterifying a compound of Formula I wherein R₁, Z, R₂, R₃, and A are as defined above and R₄ is a group of the formula i) -COOH; by reacting a compound of the formula X-(CH₂)d-CH₃ wherein X is a good leaving group and d is one to three so as to form a compound of Formula I wherein R₄ is a group of the formula: i) -COR₇, wherein R₇ is C₁ to C₄ alkoxy; wherein q is as defined above and R″ is C₁ to C₄ alkyl; wherein R″ is C₁ to C₄ alkyl and (j) is one or two; or wherein (j) is one or two, q is as defined above and R″ is C₁ to C₄ alkyl; l) demethylating a compound of Formula I wherein R₁, Z, R₃, A, and R₄ are as defined above and R₂ is a group of the formula -O-(CH₂)m-Y wherein m is one and y is a hydrogen atom under standard demethylating conditions to give a compound of Formula I wherein R₂ is a hydroxy group; or m) reacting a compound of Formula I wherein R₁, R₂, R₃, Z, and A are as defined above and R₄ is a group of the formula -COR₇, wherein R₇ is a hydroxy group, with a halogenating reagent such as POCl₃, POBr₃, PCl₅, PBr₅, SOCl₂, (O)₃PCH₃I, and the like to give a compound of Formula I wherein R₄ is a group of the formula -COR₇ wherein R₇ is a halo group; n) reacting a compound of Formula I, wherein R₁, Z, R₂, R₃, Z and A are as defined above and wherein R₄ is halo, with: i) an alkali metal cyanide to produce a compound of Formula I wherein R₄ is cyano; ii) a primary or secondary amine of the formula HNR₅R₆ to produce a compound of the Formula I wherein R₄ is a group of the formula -NR₅R₆; or iv) a thiolate anion or thiol of the formula T-S(O)p-(C₁ to C₄ alkyl) wherein T is a hydrogen atom or an alkali metal atom, to produce a compound of Formula I wherein R₄ is a group of the formula -S(O)p-(C₁ to C₄ alkyl) wherein p is zero; or o) reacting a compound of Formula I wherein R₁, Z, R₂, R₃, and A, are as defined above and R₄ is a group of the formula -COR₇, wherein R₇ is a halo group, with: i) an amine of the formula HNR₅R₆ wherein R₅ and R₆ are as defined above, to produce a compound wherein R₇ is NR₅R₆; or ii) hydroxylamine to produce a compound of Formula I wherein R₇ is a group of the formula -NHOH; or iii) 5-aminotetrazole to produce a com­ pound of Formula I wherein R₇ is a 5-aminotetrazole bonded to the acyl group through the amino group nitrogen; or iv) with a C₁ to C₄ alkanol or C₁ to C₄ alkoxide to produce a compound of Formula I wherein R₇ is C₁ to C₄ alkoxy. 2. A process for preparing a compound as claimed in claim 1 of the Formula Ia or a pharmaceutically acceptable salt thereof, wherein R₁′ is methyl or ethyl; R₂′ is hydrogen or methyl; R₃′ is ethyl, propyl, -CH₂-S-CH₃, or allyl; and R₄′ is hydroxy, cyano, -COOR′, -CONR₅R₆, -CO(C₁-C₃ alkyl), -S(O)p-(C₁-C₄ alkyl), 5-tetrazolyl optionally substituted with a C₁-C₄ alkyl group, or phenyl optionally substituted in the meta position with halo, cyano, C₁-C₃ alkyl, trifluoromethyl, -CH₂CN, -CH₂Br, C₁-C₄ alkoxy, -S(O)p-(C₁-C₄ alkyl), acetyl, or -COOR′. 3. A process for preparing a compound of Formula Ia as claimed in claim 2, wherein the compound is 2-hydroxy-4-[4-(2-methyl-2H-tetrazol-5-yl)butoxy]-5-­ ethylacetophenone, 2-hydroxy-4-[6-(methylsulfonyl)hexyl­ oxy]-5-ethylacetophenone, or 7-(4-acetyl-2-ethyl-5-­ hydroxyphenoxy)-2,2-dimethylheptanoic acid or a pharma­ ceutically acceptable salt thereof. 4. A process for preparing 3-[(4-acetyl-2-­ ethyl-5-hydroxyphenoxy)methyl]benzonitrile. 5. A process for preparing 5-ethyl-2-hydroxy-­ 4-[6-methyl-6-(1H-tetrazol-5-yl)heptyloxy]acetophenone or a pharmaceutically acceptable salt thereof. 6. A process for producing the compound in claim 5, which comprises: a) alkylating a diphenol of the formula: with 1,5-dibromopentane to produce a compound of the formula: b) alkylating the compound of Formula VI with sodium 2-cyanopropan-2-ate to produce a cyano compound of the formula c) reacting the cyano compound of Formula VII with an azide reagent such as tri(n-butyl)tin azide to give a tetrazole compound of the formula 7. A process for preparing a pharmaceutical formulation which comprises admixing a compound of Formula I, or a pharmaceutically-acceptable salt there­ of, as defined in any one of claims 1 to 5, with one or more pharmaceutically acceptable carriers or excipients therefor.

Inventors: BOLLINGER, NANCY GRACE, GOODSON, THEODORE, JR., HERRON, DAVID KENT
Applicants: ELI LILLY AND COMPANY
Application year: 1988
Main classification: C07C49
IPC codes: C07C259, C07D257, C07C317, C07C49, C07C233, A61K31, C07C65, C07C51, C07C45, C07C323, C07C241, C07D295, C07C59, C07C231, C07C69, C07D249, C07C67, C07C255, C07C235, A61P29, C07C313, C07C253, C07C247