NOVEL NAPHTHALENE DERIVATIVES AND ANTIALLERGY AND ANTI-INFLAMMATORY PHARMACEUTICALS

Abstract: Novel naphthalene derivatives of the formula (I): having antiallergy and antiinflammatory activity.

Description: Various N -1 H -tetrazol-5-yl carboxamides are disclosed having use as antiallergy agents. Particularly, U.S. Patent No. 4,432,986 discloses polycyclic carboxamides having the formula hydrogen or lower (C₁₋₄) alkyl where Ar includes the polycycle: Contrary to the disclosure of U.S. Patent Number 4,432,986 the present invention is for compounds having an alkoxy or alkylthio radical at the 1-position of 2-naphthalenecarboxamide. That is, the pattern of substituents of the compounds of the present invention is different from the dislosure of U.S. Patent No. 4,432,986. In fact, U.S. Patent No. 4,432,986 teaches a positioning of particular substituents for especially potent anti-allergic compounds. Thus, the disclosure teaches away from the positioning of the present invention compounds. Further, it is now found the compounds of the present invention are particularly potent as inhibitors of histamine release from human basophils which is contrary to that expected for the compounds as disclosed in U.S. Patent No. 4,432,986 by an ordinarily skilled artisan. In fact, the 3-methoxy naphthalene polycycle described above from 4,432,986 does not inhibit histamine release from human basophils. Of lesser interest are teachings to the compounds of U.S. Patent Nos. 3,887,574 which are amides of aminotetrazole and acid-substituted chromones, xanthones and anthraquinones; 4,145,350 which are selected tricyclic compounds having tetrazolyl groups among the substituents; 4,147,694 which are optionally substituted 8-(1H-tetrazol-5-ylcarbamoyl)quinolines; and 4,232,024 which are also compounds including a COX moiety where X may be tetrazolyl-5-amino. Such compounds are antiallergenic but do not add any teaching to the level of skill in the art pertinent to the present invention. Similarly, EP-A 0 187 487 and EP-A 0 186 367 disclose a tetrazolyl-5-amino carbonyl moiety. However, these compounds are derivatives of benzofuran or benzothiophene and indole ring systems respectively. Among the utilities for these compounds is antiallergy. The present invention relates to novel naphthalene derivatives of the formula (I) wherein X is oxygen or sulfur; R₃ is alkyl of from one to twelve carbons; and R₁ and R₂ which are at the 5- and 6- or 7- and 8-position and are independently hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, mercapto halogen, trifluoromethyl, alkylthio of 1 to 6 carbon atoms, alkylsulfinyl of 1 to 6 carbon atoms or alkylsulfonyl of 1 to 6 carbon atoms, hydroxy, nitro, amino, mono 1 to 6 C-alkyl- or di 1 to 6C-alkyl-amino, or taken together are methylenedioxy, with the proviso that sulfur atoms in R₁ and R₂ cannot have different oxidation states in the same compounds; and pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions containing the compounds of formula I and to pharmaceuticals useful in treating allergy in mammals, particularly humans, in need thereof. Alkyl of from one to twelve carbons means methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl and isomers thereof. A hydrocarbon chain of one to six carbons includes methyl, ethyl, propyl, butyl, pentyl, or hexyl and isomers thereof. Alkoxy and alkylthio of from one to six carbons include methoxy, ethoxy, propoxy, butoxy, pentoxy or hexoxy and thio-analoga and isomers thereof. Alkylsulfinyl and alkylsulfonyl radicals also contain one to six carbon atoms in their alkyl moiety. Different oxidation states of sulfur are for example thio, sulfinyl or sulfonyl chaines present in R₁ and R₂ radicals. Halogen is fluoro, chloro, bromo, or iodo. The tetrazole ring in the compounds of the invention exists in tautomeric form such that the hydrogen is on either the N¹ or N² atoms of the ring, i.e., However, for convenience, hydrogen is depicted herein simply as appearing on the N¹ atom. The novel compounds of formula I are named as derivatives of naphthalene by virtue of fused benzo rings. The fused rings are numbered clockwise starting with the carbon having the XR₃ attached as in formula I. Certain compounds within the scope of formula I are preferred, since they have a more advantageous pharmacological effect. Preferably the R¹ and R² groups are attached to the 6- or 7-position and are independently either hydrogen or methoxy respectively and preferably R₃ is isopropyl. The most preferred compound is 7-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide. In general, the procedure for preparing the novel compounds of the present invention is as shown in the following Scheme I. A tetralone compound of formula 3 wherein R₁ and R₂ are as defined above [commercially available, or prepared by the Haworth synthesis; for example, see L. F. Fieser and A. M. Seligman, J. Amer. Chem. Soc. , 170 (1938)] is heated with sulfur in order to aromatize the tetralone and yield naphthol of formula 4 having R₁ and R₂ as defined above. For example, see A. J. Shand and R. H. Thomson, Tetrahedron , 19 , 1919 (1963). The naphthol of the formula 4 is carboxylated to yield naphthoic acid of formula 5 having R₁ and R₂ as defined above by the use of: 1) potassium bicarbonate using procedures analogous to the Kolbe-Schmitt reaction; see A. S. Lindsey and H. Jeskey, Chem. Rev. , 57 , 583 (1957) or, 2) magnesium methyl carbonate (known as the Stiles reagent) using procedures analogous to those of L. A. Cate, Synthesis , 385 (1983). Naphthoic acid of the formula 5 is esterified to yield naphthoic enol ester of formula 6 having R₁ and R₂ as defined above, and the enolic OH group of the formula 6 is then alkylated to yield alkoxy ester of formula 7 wherein R₁, R₂, and R₃ are as defined above. Reagents for alkylation include alkyl halides, alkyl sulfonates, and isoureas. See L. J. Mathias, Synthesis , 561 (1979). Alkoxy esters of the formula 7 are frequently oils and the crude product is saponified to yield alkoxy acids of formula 8 wherein R₁, R₂, and R₃ are as defined above. The acid of the formula 8 is converted to the carbamoyltetrazole of the formula I as defined above by coupling with 5-aminotetrazole. Coupling reagents can include 1,1'-carbonyldiimidazole, DCC(1,3-dicyclohexylcarbodiimide), or other peptide-coupling reagents. Salts of the compound of the formula I can be prepared by reacting with inorganic or organic bases such as is described below. An alternate synthetic route to intermediates of the formula 6 is shown in Scheme II. Tetralone of the formula 3 as defined for Scheme 1 is converted to the enolic keto-ester of formula 9 wherein R₁ and R₂ are as defined above, by carboxylation with dimethyl carbonate and sodium hydride. This procedure is analogous to that of D. W. Johnson and L. N. Mander, Aust. J. Chem. , 27 , 1277 (1974). For an additional analogous route to a compound of the formula 9 , see W. E. Bachmann and D. G. Thomas, J. Amer. Chem. Soc. , 64 , 94 (1942). The ester of the formula 9 is brominated with N-bromosuccinimide in the presence of a free radical initiator. Catalysts that can be used for this purpose include benzoyl peroxide, α,α-azoisobutyronitrile ("AIBN"), and others. The bromo-ester intermediate of formula 10 wherein R₁ and R₂ are as defined above is treated with a base to effect dehydrohalogenation and yield the naphthalene enol ester of the formula 6 . Among the bases that can be employed are pyridine, N,N-diethylaniline, 1,8-diazabicyclo[5.4.0]undec-7-ene ("DBU"), and others. The starting materials required for the processes described in this invention are either commercially available or can be synthesized by methods known in the art. The compounds of formula I are useful both in the free acid form, in the form of base salts, and in the form of acid addition salts. The three forms are within the scope of the invention. In practice, use of the salt form amounts to use of the base form. Appropriate pharmaceutically acceptable salts within the scope of the invention are those derived from mineral acids such as hydrochloric acid and sulfuric acid; and organic acids such as methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, and the like, giving the hydrochloride, sulfamate, methanesulfonate, benzenesulfonate, p-toluenesulfonate, and the like, respectively or those derived from bases such as suitable organic and inorganic bases. Examples of suitable inorganic bases for the formation of salts of compounds of this invention include the hydroxides, carbonates, and bicarbonates of ammonia, sodium, lithium, potassium, calcium, magnesium, aluminum, zinc, and the like. Salts may also be formed with suitable organic bases. Bases suitable for the formation of pharmaceutically acceptable base addition salts with compounds of the present invention include organic bases which are nontoxic and strong enough to form such salts. These organic bases form a class whose limits are readily understood by those skilled in the art. Merely for purposes of illustration, the class may be said to include mono-, di-, and trialkylamines, such as methylamine, dimethylamine, and triethylamine; mono-, di- or trihydroxyalkylamines such as mono-, di- and triethanolamine; amino acids such as arginine, and lysine; guanidine; N -methylglucosamine; N -methylpiperazine; morpholine; ethylenediamine; N -benzylphenethylamine; tris(hydroxymethyl)aminomethane; and the like. (See for example, "Pharmaceutical Salts," J. Pharm. Sci. , 66 (1), 1-19 (1977).) The acid addition salts of said basic compounds are prepared either by dissolving the free base of compound I in aqueous or aqueous alcohol solution or other suitable solvents containing the appropriate acid or base, and isolating the salt by evaporating the solution, or by reacting the free base of compound I with an acid, as well as reacting compound I having an acid group thereon with a base such that the reactions are in an organic solvent, in which case the salt separates directly or can be obtained by concentration of the solution. The base salts of compounds of formula I described above are prepared by reacting the appropriate base with stoichiometric equivalent of the acid compounds of formula I to obtain pharmacologically acceptable base salts thereof. The acid solution salts of said basic compounds are prepared either by dissolving the free base in aqueous or aqueous alcohol solution or other suitable solvents containing the appropriate acid and isolating the salt by evaporating the solution, or by reacting the free base and acid in an organic solvent, in which case the salt separates directly or can be obtained by concentration of the solution. The compounds of this invention may also exist in hydrated or solvated forms. The products of the reactions described herein are isolated by conventional means such as extraction, distillation, chromatography and the like. The antiallergic activity not within that expected of the compounds having the formula I of the present invention is shown by an assay determining inhibition of the release of histamine from human basophils (HHB). A description of the protocol for the HHB assay is found hereinafter. Thus, pharmaceutical compositions are prepared from the compounds of formula I and salts thereof described as the present invention in unit dosage form comprising the compound either alone or in admixture with a pharmaceutically acceptable carrier appropriately selected from those known. A physician or veterinarian of ordinary skill readily determines a subject who is exhibiting allergic or inflammatory symptoms. Regardless of the route of administration selected, the compounds of the present invention are formulated into pharmaceutically acceptable dosage forms by conventional methods known to the pharmaceutical art. The compounds can be administered in such oral unit dosage forms such as tablets, capsules, pills, powders, or granules. They also may be administered rectally or vaginally in such forms as suppositories or bougies. They may also be introduced parenterally (e.g., subcutaneously, intravenously, or intramuscularly), using forms known to the pharmaceutical art. They are also introduced directly to an affected area, (e.g., in the form of eye drops or by inhalation). For the treatment of allergic or inflammatory conditions such as erythema, the compounds of the present invention may also be administered topically in the form of ointments, creams, gels, or the like. In general, the preferred route of administration is orally. An effective but nontoxic quantity of the compound I is employed in treatment. The ordinarily skilled physician or veterinarian will readily determine and prescribe the effective amount of the antiallergic or antiinflammatory agent to prevent or arrest the progress of the condition. The dosage regimen is selected in accordance with a variety of factors including the type, age, weight, sex, and medical condition of the mammal, the severity of symptoms of the disease being treated, the route of administration and particular compound of formula I employed. An ordinarily skilled physician or veterinarian will readily determine and prescribe the effective amount of the compound I to prevent or arrest the progress of the condition. In so proceeding, the physician or veterinarian could employ relatively low dosages at first, subsequently increasing the dose until a maximum response is obtained. For convenience, the total daily dosage may be divided and administered in portions during the day if desired. In so proceeding the physician or veterinarian could employ relatively low dosages at first, subsequently increasing the dose until a maximum response is obtained. Initial dosages of the compounds of the invention having formula I are ordinarily in the area of 10 mg up to 2 g per day orally, preferably 10 mg to 500 mg per dose orally, given from one to four times daily or as needed. When other forms of administration are employed equivalent doses are administered. It is understood that the compositions of the present invention as described above also include the free acid, the pharmacologically acceptable base salts and acid addition salts of the compounds of formula I. The following examples further illustrate the invention, but are not meant to be limiting thereto. PREPARATION- EXAMPLE 1 6-Methoxy-1-naphthalenol . A mixture of 50.0 g (0.28 mole) of 6-methoxy-1-tetralone and 9.2 g (0.29 mole) of elemental sulfur was stirred and heated at 250-260° for three hours (until the evolution of hydrogen sulfide gas had ceased). The mixture was cooled and then subjected to bulb-to-bulb distillation. The distillate was dissolved in 300 ml of dichloromethane, and the solution was extracted with 1.0 N potassium hydroxide solution (3 x 150 ml). The base extracts were combined, cooled in ice, and acidified with 10% hydrochloric acid to precipitate the crude naphthol product as a gum. Trituration of the gum with tert-butyl methyl ether yielded 16.8 g (34% yield) of the analytically pure naphthol, mp 84-86° (a mp of 83-84° is given by M. P. Sibi, J. W. Dankwardt, and V. Snieckus, J. Org. Chem. , 51 , 271 (1986)). Calcd. for C₁₁H₁₀O₂: C, 75.84; H, 5.79 Found C, 75.66; H, 5.69. Also prepared by a procedure analogous to the above procedure from the appropriate tetralone were: PREPARATION-EXAMPLE 2 5-Methoxy-1-naphthalenol . Mp 136-138° (a mp of 136-138° is given by M. P. Sibi, et al., cited above). Calcd. for C₁₁H₁₀O₂: C, 75.84; H, 5.79 Found C, 75.88; H, 5.84, PREPARATION-EXAMPLE 3 7-Methoxy-1-naphthalenol . Mp 105-107° (a mp of 103-105° is given by A. J. Shand and R. H. Thomson, Tetrahedron , 19 , 1919 (1963)). Calcd. for C₁₁H₁₀O₂: C, 75.84; H, 5.79 Found C, 75.49; H, 5.85, and PREPARATION-EXAMPLE 4 7-(1-Methylethoxy)-1-naphthalenol . Mp 127-129°. Calcd. for C₁₃H₁₄O₂: C, 77.20; H, 6.98 Found C, 77.48; H, 6.87. PREPARATION-EXAMPLE 5 A flask containing 164 g (1.42 mole) of pyridine hydrochloride in a nitrogen atmosphere was stirred and heated to 190°. After 30 minutes, 50.0 g (0.28 mole) of 7-methoxy-1-tetralone was added in one portion, and heating at 190° was continued for two hours. The mixture was cooled and poured over 2.0 kg of ice/water. The precipitated solid was filtered and washed with water to yield 37.7 g (97% yield) of the analytically pure phenol product, mp 154-156° (a mp of 159° is given by J. V. Braun, Ann. , 451 , 1 (1927)). Calcd. for C₁₀H₁₀O₂: C, 74.06; H, 6.21 Found C, 74.06; H, 6.22. PREPARATION-EXAMPLE 6 A suspension of 24.3 g (0.22 mole) of potassium tert-butoxide in 240 ml of dimethyl sulfoxide under a nitrogen atmosphere was stirred and cooled in a cold water bath while a solution of 29.2 g (0.18 mole) of 3,4-dihydro-7-hydroxy-1(2 H )-naphthalenone in 400 ml of dimethyl sulfoxide was added dropwise over 45 minutes. The mixture was stirred at room temperature for an additional 45 minutes, and then 23.7 ml (31.0 g; 0.25 mole) of 2-bromopropane was added in one portion. After stirring for an additional 30 hours, the mixture was added to 2.0 kg of ice/water and extracted with dichloromethane (4 x 300 ml). The combined organic layers were back-washed with water (2 x 150 ml), dried (anhydrous magnesium sulfate), and evaporated (vacuum) to an oil residue. Flash chromatographic purification (silica gel, dichloromethane elution) of the residue yielded 24.0 g (65% yield) of the analytically pure ether product as an oil, suitable for conversion to the naphthol described in Example 4. Calcd. for C₁₃H₁₆O₂: C, 76.44; H, 7.90 Found C, 76.44; H, 7.86. PREPARATION-EXAMPLE 7 1-Hydroxy-6-methoxy-2-naphthalenecarboxylic acid . A mixture of 14.0 g (0.080 mole) of 6-methoxy-1-naphthalenol and 100 ml (0.25 mole) of a 2.5 M solution of magnesium methyl carbonate in N,N-dimethylformamide were sealed in a 300 cc pressure reactor and pressurized to 550 psi with nitrogen gas. The reactor was heated to 180° for six hours without agitation, cooled, and then the reaction mixture was added to 1.75 kg of ice/water. The mixture was acidified with 6.0 N aqueous hydrochloric acid. The precipitated crude product was filtered, stirred in 350 ml of fresh water, and re-filtered. The solid was dissolved with warming in 600 ml of 5% aqueous sodium bicarbonate solution, and the solution was decolorized with activated charcoal. The filtrate from the charcoal treatment was cooled, washed with ethyl acetate (2 x 400 ml), cooled in ice, and again acidified with 6.0 N aqueous hydrochloric acid. The precipitated product was filtered and washed with water to yield 14.0 g (80% yield) of the analytically pure hydroxy acid, mp 188° dec. Calcd. for C₁₂H₁₀O₄: C, 66.05; H, 4.62 Found C, 66.36; H, 4.74. Also prepared by a procedure analogous to the above procedure of Example 7 using the appropriate naphthol were: PREPARATION-EXAMPLE 8 1-Hydroxy-5-methoxy-2-naphthalenecarboxylic acid . Mp 197°-dec. (a mp of 212.5-213° is given by P. Hill, W. F. Short, and H. Stromberg, J. Chem. Soc. , 937 (1937)). Calcd. for C₁₂H₁₀O₄·0.25H₂O: C, 64.71; H, 4.75 Found C, 64.38; H, 4.75, PREPARATION-EXAMPLE 9 1-Hydroxy-7-methoxy-2-naphthalenecarboxylic acid . Mp 196°-dec. Calcd. for C₁₂H₁₀O₄·0.25H₂O: C, 64.71; H, 4.75 Found C, 65.06; H, 4.62, and PREPARATION-EXAMPLE 10 1-Hydroxy-7-(1-methylethoxy)-2-naphthalenecarboxylic acid . Mp 189° dec. Calcd. for C₁₄H₁₄O₄: C, 68.28; H, 5.73 Found C, 68.29; H, 5.76. PREPARATION-EXAMPLE 11 1-Hydroxy-7-methoxy-2-naphthalenecarboxylic acid, methyl ester . A suspension of 6.2 g (0.028 mole) of 1-hydroxy-7-methoxy-2-naphthalenecarboxylic acid in 75 ml of methanol under a nitrogen atmosphere was treated over 15 minutes with 15.0 ml (17.3 g; 0.12 mole) of boron trifluoride etherate. The mixture was stirred at reflux for 45 hours, cooled, and added slowly to 500 ml of ice cold 5% aqueous sodium bicarbonate solution. The precipitated product was filtered, and washed with water to yield 6.0 g (92% yield) of the ester, mp 80-83°, suitable for further synthetic use. A sample purified by chromatography (silica gel, dichloromethane elution) was analytically pure, mp 79-81° (a mp of 81-82° is given by M. E. Alonso, A. W. Chitty, S. Pekerar, and M. de L. Borgo, J. Chem. Soc. Chem. Comm. , 1542 (1984). Calcd. for C₁₃H₁₂O₄: C, 67.23; H, 5.21 Found C, 67.33; H, 5.18. Also prepared by a procedure analogous to the above procedure of Example 11 using the appropriate carboxylic acid were: PREPARATION-EXAMPLE 12 1-Hydroxy-2-naphthalenecarboxylic acid, methyl ester . Mp 74-76° (a mp of 76-77° is given by N. J. P. Broom and P. G. Sammes, J. Chem. Soc. Perk. I , 465 (1981)). Calcd. for C₁₂H₁₀O₃: C, 71.28; H, 4.98 Found C, 71.06; H, 5.03, PREPARATION-EXAMPLE 13 1-Hydroxy-5-methoxy-2-naphthalenecarboxylic acid, methyl ester . Mp 114-116° (a mp of 118-119° is given by P. Hill, et al., previously cited). Calcd. for C₁₃H₁₂O₄: C, 67.23; H, 5.21 Found C, 67.37; H, 5.14, PREPARATION-EXAMPLE 14 1-Hydroxy-6-methoxy-2-naphthalenecarboxylic acid, methyl ester . Mp 108-110°. Calcd. for C₁₃H₁₂O₄: C, 67.23; H, 5.21 Found C, 67.27; H, 5.15, and PREPARATION-EXAMPLE 15 1-Hydroxy-7-(1-methylethoxy)-2-naphthalenecarboxylic acid, methyl ester . Mp 77-79°. Calcd. for C₁₅H₁₆O₄: C, 69.22; H, 6.20 Found C, 69.17; H, 6.45. PREPARATION-EXAMPLE 16 6-Methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid . A suspension of 5.2 g (0.046 mole) of potassium tert-butoxide in 45 ml of dimethyl sulfoxide under a nitrogen atmosphere was treated over 20 minutes with a solution of 7.5 g (0.032 mole) of 1-hydroxy-6-methoxy-2-naphthalenecarboxylic acid, methyl ester in 80 ml of dimethyl sulfoxide. The mixture was stirred for 45 minutes, then treated in one portion with 4.6 ml (6.0 g; 0.049 mole) of 2-bromopropane. The mixture was stirred at room temperature for 72 hours, then added to 750 g of ice/water. The alkoxy-ester intermediate was separated by extracting with dichloromethane (3 x 150 ml). The combined organic extracts were washed with water (1 x 200 ml), 0.5 N aqueous potassium hydroxide solution (2 x 200 ml), and water again. The organic layer was dried (anhydrous magnesium sulfate) and evaporated (vacuum) to yield 7.9 g (90% yield) of the crude intermediate 6-methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid, methyl ester as a yellow oil. The total crude residue described above was dissolved in 50 ml of methanol and treated with a solution of 4.2 g (0:075 mole) of potassium hydroxide in 50 ml of water. The mixture was stirred at reflux for two hours, cooled, and added to 500 g of ice/water. Acidification with 6.0 N hydrochloric acid yielded the crude carboxylic acid product as a gum. The gum was extracted with dichloromethane (3 x 75 ml), and the combined extracts were back-washed with water (1 x 150 ml), dried (anhydrous magnesium sulfate), and evaporated. Trituration of the residue with ether/hexane yielded 5.7 g (68% yield) of the analytically pure carboxylic acid product, mp 138-141°. Calcd. for C₁₅H₁₆O₄: C, 69.21; H, 6.20 Found C, 69.54; H, 6.16. Also prepared by a procedure analogous to the above procedure of Example 16 using the appropriate hydroxy ester were: PREPARATION-EXAMPLE 17 1-(1-Methylethoxy)-2-naphthalenecarboxylic acid . Mp 109-111°. Calcd. for C₁₄H₁₄O₃: C, 73.02; H, 6.13 Found C, 73.13; H, 6.38, PREPARATION-EXAMPLE 18 5-Methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid . Mp 129-131°. Calcd. for C₁₅H₁₆O₄: C, 69.21; H, 6.20 Found C, 68.91; H, 5.96, PREPARATION-EXAMPLE 19 7-Methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid . Mp 106-109°. Calcd. for C₁₅H₁₆O₄: C, 69.21; H, 6.20 Found C, 68.98; H, 6.32, and PREPARATION-EXAMPLE 20 1,7-bis(1-Methylethoxy)-2-naphthalenecarboxylic acid . Mp 90-92°. Calcd. for C₁₇H₂₀O₄: C, 70.81; H, 6.99 Found C, 70.72; H, 7.11. PREPARATION-EXAMPLE 21 1,7-Dimethoxy-2-naphthalenecarboxylic acid . A mixture of 3.7 g (0.016 mole) of 1-hydroxy-7-methoxy-2-naphthalenecarboxylic acid, methyl ester and 2.9 g (0.021 mole) of anhydrous potassium carbonate in 20 ml of N,N-dimethylformamide under a nitrogen atmosphere was treated with 3.0 ml (6.8 g; 0.048 mole) of iodomethane. The mixture was stirred at room temperature for 24 hours, and then added to 150 g of ice/water. The crude intermediate ester was separated by extracting with dichloromethane (3 x 50 ml). The combined organic layers were washed with water (2 x 50 ml), dried (anhydrous magnesium sulfate) and evaporated (vacuum). The total crude residue obtained above was saponified as described in Example 16. The analytically pure carboxylic acid product was 2.7 g (73% yield), mp 130-132°. Calcd. for C₁₃H₁₂O₄: C, 67.23; H, 5.21 Found C, 67.32; H, 5.23. EXAMPLE 22 6-Methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide . A mixture of 4.5 g (0.017 mole) of 6-methoxy-1-(1-methylethoxy)-2-naphthalenecarboxylic acid and 3.2 g (0.020 mole) of 1,1'-carbonyldiimidazole in 40 ml of acetonitrile under a nitrogen atmosphere was stirred at reflux for one hour. The mixture was cooled, treated with 1.7 g (0.020 mole) of anhydrous 5-aminotetrazole and 5.6 ml (4.1 g; 0.040 mole) of triethylamine, and again stirred at reflux for five hours. The reaction mixture was cooled, added to 500 g of ice/water, and acidified with glacial acetic acid. The precipitated solid was filtered and washed with water to yield 5.4 g (97% yield) of the analytically pure carbamoyltetrazole product, mp 265°-dec. Calcd. for C₁₆H₁₇N₅O₃: C, 58.72; H, 5.24; N, 21.40 Found C, 58.89; H, 5.30; N, 21.00. Also prepared by a procedure analogous to the above procedure of Example 22 using the appropriate carboxylic acid were: EXAMPLE 23 1-(1-Methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide . Mp 267° dec. Calcd. for C₁₅H₁₅N₅O₂: C, 60.59; H, 5.09; N, 23.56 Found C, 60.79; H, 5.33; N, 23.55, EXAMPLE 24 1,7-Dimethoxy-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide . Mp 242° dec. Calcd. for C₁₄H₁₃N₅O₃: C, 56.18; H, 4.38; N, 23.40 Found C, 56.22; H, 4.25; N, 23.13, EXAMPLE 25 5-Methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide . Mp 278° dec. Calcd. for C₁₆H₁₇N₅O₃: C, 58.72; H, 5.24; N, 21.40 Found C, 58.43; H, 5.18; N, 21.54, EXAMPLE 26 7-Methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide . Mp 252° dec. Calcd. for C₁₆H₁₇N₅O₃: C, 58.72; H, 5.24; N, 21.40 Found C, 58.32; H, 5.04; N, 21.49, and EXAMPLE 27 1,7-bis(1-Methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide . Mp 235° dec. Calcd. for C₁₈H₂₁N₅O₃: C, 60.83; H, 5.96; N, 19.71 Found C, 60.44; H, 5.82; N, 19.78. EXAMPLE 28 6-Methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide, sodium salt . A suspension of 3.27 g (0.010 mole) of 6-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide in 30 ml of methanol was treated with 5.0 ml of 2.00 N aqueous sodium hydroxide solution. The mixture was digested on the steam bath for several minutes and filtered hot. The cooled filtrate was evaporated (vacuum) to one-half of its original volume. The solution was cooled in an ice bath, and the precipitated solid was filtered and washed several times with cold methanol to yield 3.0 g (87% yield) of the analytically pure sodium salt, mp 190° dec. Calcd. for C₁₆H₁₆N₅O₃Na: C, 55.01; H, 4.62; N, 20.05 Found C, 55.03; H, 4.81; N, 20.09. EXAMPLE 29 7-Methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide, sodium salt . A suspension of 5.5 g (0.017 mole) of 7-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide in 200 ml of methanol was treated with 8.5 ml of 2.00 N aqueous sodium hydroxide solution. The mixture was digested on the steam bath for ten minutes and filtered hot. The cooled filtrate was evaporated (vacuum) to dryness, and the residue was re-dissolved several times in 2-propanol and re-evaporated. Trituration of the final residue with acetonitrile yielded 5.1 g (86% yield) of the analytically pure sodium salt containing 0.25 equivalent of water of hydration, mp 193-197°. Calcd. for C₁₆H₁₆N₅O₃Na·0.25H₂O: C, 54.31; H, 4.70; N, 19.80 Found C, 54.06; H, 4.53; N, 19.66. PREPARATION-EXAMPLE 30 1,2,3,4-Tetrahydro-6-methoxy-1-oxo-2-naphthalenecarboxylic acid, methyl ester . A suspension of 24.0 g (0.60 mole) of sodium hydride (60% dispersion in mineral oil) and 49.5 ml (52.9 g; 0.59 mole) of dimethyl carbonate (freshly distilled from sodium hydride) in 240 ml of tetrahydrofuran under a nitrogen atmosphere was stirred and heated to reflux. Reflux was maintained while a solution of 29.7 g (0.17 mole) of 6-methoxy-1-tetralone in 105 ml of tetrahydrofuran was added dropwise over two hours. After addition was complete, the mixture was stirred at reflux for an additional 90 minutes, cooled in ice, and treated dropwise with 36 ml of glacial acetic acid, followed by 450 ml of ice water. The two-phase reaction mixture was extracted with ethyl acetate (4 x 250 ml), and the combined organic layers were washed with water (1 x 600 ml), 5% aqueous sodium bicarbonate solution (3 x 600 ml), and water again. The ethyl acetate extract was dried (anhydrous sodium sulfate) and evaporated (vacuum). The residue was pulverized and stirred in 500 ml of hexane. Filtration yielded 37.9 g (96% yield) of the ester product, mp 79-81°, suitable for further synthesis. A sample purified by bulb-to-bulb distillation followed by recrystallization from hexane/ethyl acetate was analytically pure, mp 82-84° (a mp of 88-89° is given by J. Jacques and A. Horeau, Bull. Soc. Chem. France , 512 (1950)). Calcd. for C₁₃H₁₄O₄: C, 66.65; H, 6.02 Found C, 66.69; H, 6.00. PREPARATION-EXAMPLE 31 1,2,3,4-Tetrahydro-2-bromo-6-methoxy-1-oxo-2-naphthalenecarboxylic acid, methyl ester . A solution of 5.2 g (0.022 mole) of 1,2,3,4-tetrahydro-6-methoxy-1-oxo-2-naphthalenecarboxylic acid, methyl ester in 40 ml of chloroform under a nitrogen atmosphere was treated, in portions, with 4.4 g (0.025 mole) of N-bromosuccinimide, followed by 0.025 g (0.00015 mole) of α,α-azobisisobutyronitrile. The mixture was stirred at reflux for one hour, cooled in ice, and diluted with 30 ml of hexane. The precipitated succinimide by-product was filtered and discarded. Evaporation (vacuum) of the filtrate and recrystallization of the residue from ether/petroleum ether yielded 5.1 g (73% yield) of the analytically pure bromo ester, mp 99-101°. Calcd. for C₁₃H₁₃BrO₄: C, 49.86; H, 4.18; Br, 25.52 Found C, 49.79; H, 4.16; Br, 25.40. PREPARATION-EXAMPLE 32 1-Hydroxy-6-methoxy-2-naphthalenecarboxylic acid, methyl ester (alternate procedure). A solution of 10.2 g (0.033 mole) of 1,2,3,4-tetrahydro-2-bromo-6-methoxy-1-oxo-2-naphthalenecarboxylic acid, methyl ester in 100 ml of tetrahydrofuran under a nitrogen atmosphere was treated over 15 minutes with a solution of 10.0 ml (10.2 g; 0.067 mole) of 1,8-diazabicyclo[5.4.0]undec-7-ene in 20 ml of tetrahydrofuran. The mixture was stirred at room temperature for 16 hours, then added to 450 g of ice/water. Acidification with 6.0 N hydrochloric acid precipitated the crude naphthalene ester product. The solid was filtered, washed with water, and recrystallized from aqueous methanol to yield 5.1 g (67% yield) of the final product, mp 109-111°. This material was identical with that prepared by the procedure described in Example 11. The usefulness of the compounds of the present invention as inhibitors of histamine release is demonstrated by the following tests, particularly the assay for histamine release from human basophils or HHB. The HHB test is essentially as generally accepted among the ordinarily skilled artisans to show activity having unique usefulness to treat the diseases or conditions as set out in the present invention. Additonally, the fragmented lung anaphylaxis test, or FLAT, is generally accepted among the ordinarily skilled artisan to show activity having usefulness to treat the diseases or conditions set out herein. A description of each procedure follows. HISTAMINE RELEASE FROM HUMAN BASOPHILS (hereinafter HHB) The HHB assay quantitates active histamine release and its inhibition by drugs, from basophils of human blood. Thus, the assay provides evaluation of the compounds of formula I for treating the conditions or diseases as is the present invention. As described herein the assay includes modifications of the method described by R. P. Siraganian in "An Automated Continuous-Flow System for the Extraction and Fluorometric Analysis of Histamine", Anal. Biochem. , 57 , 383-394 (1974). METHODS Preparation of Leukocytes Seventy ml of blood are drawn from allergic donors (chosen on the basis of adequate histamine induced by a challenge), using standard venipuncture methods, into 10 ml Vacutainers with 0.08 ml/tube 15% EDTA in water as anticoagulant. The blood samples are placed briefly on a rotary mixer. All glassware contacting the blood is siliconized. The blood is aliquoted into three plastic 50 ml centrifuge tubes and the volume is noted. Hespan (hydroxy ethyl starch), 0.5 ml per 1.0 ml of blood, is added. The tubes are inverted several times to mix and are left undisturbed at room temperature until a sharp separation is observed between the settled red cells and the leukocyte and platelet-rich plasma. This usually occurs within 35-45 minutes. The plasma fraction is pipetted off and placed into two clean plastic 50 ml centrifuge tubes. The tubes are centrifuged for 12 minutes at 4° in a Sorval RC-3 centrifuge with an HL-8 rotor at 1050 RPM (100 g). The platelets remain in the plasma and are discarded. The pelleted leukocytes are shaken gently to disrupt the cell button and washed twice as described: Wash 1. Five ml of HA buffer with 0.005 M EDTA is added to the dispersed cells in each tube and gently vortexed. 25 ml of buffer is then added and gently vortexed. The samples are again centrifuged as described earlier. The supernatant is poured off, and the cell button in each tube is gently dispersed. Wash 2. Five ml of HA buffer with EDTA is added to each tube to resuspend the cells. Leukocytes are then pooled into one tube and the volume is brought up to 40 ml with HA buffer with EDTA and gently vortexed. The pooled sample is centrifuged at 1050 RPM for 12 minutes. The supernatant fluid is discarded and the cell button is dispersed. Sixteen ml of HACM buffer is added to the washed cells and gently vortexed. A sample is prepared for Hematology, where a total white blood cell and platelet count is done using a Coulter Counter. Aliquots (0.1 ml) of cells are added to assay tubes containing 0.4 ml of either 6% perchloric acid (for total histamine content), vehicle control (for spontaneous release), or drug. The tubes are incubated at room temperature for 8 minutes, and then placed in a 37° water bath for two more minutes. Buffer or challenge agents (at 37°) are added to the tube and they are incubated for an additional 45 minutes at 37°. The tubes are then spun at 2000 RPM (1200 g) for three minutes to pellet the cells and the supernatants are poured into assay cups. Drug Preparation A 300 µM stock solution of each test compound is prepared as follows: an appropriate amount of compound (molecular weight/33.33) is weighed out into a 100 ml volumetric flask and 0.5 ml DMSO is added. If the compound does not dissolve readily, it is warmed gently on a hot plate and approximately 30 ml of distilled water is added. If the compound is in solution, distilled water is used to bring it up to 100 ml total volume. If the drug is not in solution, 0.2 ml 1 N NaOH (or HCl) is added, and then distilled water is added to yield 100 ml total solution. Five ml of the stock solution is diluted (1:2) with 5 ml of two times concentrated HACM (Hepes Albumin Calcium Magnesium) buffer to yield the stock working concentration of 150 µM. When added to the cells and stimulus, a final test concentration of 100 µM drug results (400 µl drug, 100 µl cells and 100 µl challenge agent or vehicle). Further dilutions are made with HACM buffer for 33, 10, 3.3, 1.0 µM, etc. Challenge Agent Preparation Short ragweed and house dust extracts (Greer Laboratories, Inc.) are supplied as aqueous extracts in stock concentrations of 40,000 and 10,000 protein nitrogen units per milliliter (PNU/ml), respectively. Aqueous solutions of anti-IgE antisera (rabbit-raised antibody) are purchased from Dako via Accurate Chemicals. The tripeptide f-met-leu-phe (fmlp) from Vega Biochemicals is used. The aqueous solutions of ragweed, house dust, and anti-IgE are diluted 1:2 with two times concentrated HACM and then further diluted with HACM to yield final stock concentrations of 6000 PNU/ml for ragweed and house dust, and a 1:50 dilution for the anti-IgE antisera. For fmlp, 28.5 mg of the tripeptide is dissolved in 1 ml of DMSO or 1 ml glacial acetic acid, then 49 ml distilled water and 50 ml of two times HACM are added to yield a final stock of 600 µM in HACM. The pH is adjusted to 7.4. Further dilutions for working solutions are made in HACM buffer. All stock and working solutions are stored at 4°. Working solutions comprise 1/6 of the final volume in the cell reaction, therefore, working solutions of challenge agents are made up six times the required final concentration (i.e., 600 µM f-met-leu-phe yields 100 µM final concentration in the cellular reaction). Protocol Design Samples are run in triplicate, using either 1.5 ml polypropylene-capped reaction tubes, or 5.0 ml plastic uncapped tubes. Test compounds and challenge agents are prepared in HACM buffer, as described above. Fixed volume pipettes are used. Test compound or vehicle control is added to three reaction tubes at 1.5x the final desired concentration (i.e., 400 µl of test compound per 600 µl total reaction volume). One hundred µl of cells is added to each tube and the mixture is incubated for eight minutes at room temperature, and two minutes at 37° before antigen or other stimulus challenge. One hundred µl of the challenge agent at 6x the final concentration is then added, and the final mixture is incubated at 37° for 45 minutes in a shaking water bath. This ensures that the cell preparation is constantly in suspension. The reaction is stopped by centrifugation at 2000 RPM for three minutes at 4°. The supernate (≈ 500 µl) is poured into 2.0 ml autoanalyzer beakers and assayed for histamine by the fluorometric method. In each experiment, cells from one donor are challenged with one or more of the challenge agents, according to the designed protocol and the previously determined sensitivity of the donor to particular challenge agents. Short ragweed and house dust concentrations are expressed in PNU/ml, fmlp challenges are in micromolar concentration (µM), and anti-IgE antisera and C5a challenges are in dilutions, e.g., IE-5 (1:100,000), 3E-5 (1:30,000), and 1E-4 (1:10,000). Calculation and Interpretation of Results The total histamine concentration in the "total" (acid-treated) samples must be 15 ng/ml to be acceptable. Spontaneous release of histamine from the cells should not exceed 15% of the total histamine, and is frequently < 5%. The maximum percentage histamine released varies with the donor. The net amount released by the challenge agent must exceed 25% of the total cellular histamine to confidently assess inhibition by test compounds. Spontaneous histamine release is subtracted from both "totals" and challenged cells to calculate net percent release. Percent inhibition is calculated using the following formula: Using the HHB assay the compounds of formula I are generally shown by the examples tested to inhibit the release of histamine from human basophils challenged with antigen and, thus, to have activity different from that expected by an ordinarily skilled artisan. The results are shown in the table as follows: HHB TEST Example No. % Inhibition of Histamine Release with Anti-IgE Stimulus (tested at [33 µM]) 23 16 24 57 25 11 22 71 26 91 27 0 at highest dose tested Accordingly, the present invention also includes a pharmaceutical composition for treating one of the above diseases or conditions comprising an antidisease or anticondition effective amount of a compound of the formula I as defined above together with a pharmaceutically acceptable carrier. The present invention further includes a method for treating one of the above named diseases or conditions in mammals, including man, suffering therefrom comprising administering to such mammals either orally or parenterally, preferably oral, a corresponding pharmaceutical composition containing a compound of formula I as defined above in appropriate unit dosage form. For preparing pharmaceutical compositions from the compounds described by this invention, inert, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets, and suppositories. A solid carrier can be one or more substances which may also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders or tablet disintegrating agents. It can also be encapsulating material. In powders, the carrier is a finely divided active compound. In the tablet the active compound is mixed with carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain from 5 or 10 to about 70 percent of the active ingredient. Suitable solid carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier providing a capsule in which the active component (with or without other carriers) is surrounded by carrier, which is thus in association with it. Similarly, cachets are included. Tablets, powders, cachets, and capsules can be used as solid dosage forms suitable for oral administration. For preparing suppositories, a low melting wax such as a mixture of fatty acid glycerides or cocoa butter is first melted, and the active ingredient is dispersed homogeneously therein as by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool and thereby to solidify. Liquid form preparations include solutions, suspensions, and emulsions. As an example may be mentioned water or water-propylene glycol solutions for parenteral injection. Liquid preparations can also be formulated in solution in aqueous polyethylene glycol solution. Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizing and thickening agents as desired. Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, i.e., natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well-known suspending agents. Also included are solid form preparations which are intended to be converted, shortly before use, to liquid form preparations for either oral or parenteral administration. Such liquid forms include solutions, suspensions, and emulsions. These particular solid form preparations are most conveniently provided in unit dose form and as such are used to provide a single liquid dosage unit. Alternately, sufficient solid may be provided so that after conversion to liquid form, multiple individual liquid doses may be obtained by measuring predetermined volumes of the liquid form preparation as with a syringe, teaspoon, or other volumetric container. When multiple liquid doses are so prepared, it is preferred to maintain the unused portion of said liquid doses at low temperature (i.e., under refrigeration) in order to retard possible decomposition. The solid form preparations intended to be converted to liquid form may contain, in addition to the active material, flavorants, colorants, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. The liquid utilized for preparing the liquid form preparation may be water, isotonic water, ethanol, glycerine, propylene glycol, and the like as well as mixtures thereof. Naturally, the liquid utilized will be chosen with regard to the route of administration, for example, liquid preparations containing large amounts of ethanol are not suitable for parenteral use. Preferably, the pharmaceutical preparation is in unit dosage form. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, for example, packeted tablets, capsules, and powders in vials or ampules. The unit dosage form can also be a capsule, cachet, or tablet itself or it can be the appropriate number of any of these in packaged form. The quantity of active compound in a unit dose of preparation may be varied or adjusted from 10 mg to 2,000 mg preferably to 10 to 500 mg according to the particular application and the potency of the active ingredient. The compositions can, if desired, also contain other compatible therapeutic agents.

Claims: A naphthalene derivative of the formula (I) wherein X is oxygen or sulfur; R₃ is alkyl of from one to twelve carbons; and R₁ and R₂ which are at the 5- and 6- or 7- and 8-position and are independently hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, mercapto, halogen, trifluoromethyl, alkylthio of 1 to 6 carbon atoms, alkylsulfinyl of 1 to 6 carbon atoms or alkylsulfonyl of 1 to 6 carbon atoms, hydroxy, nitro, amino, mono 1 to 6 C-alkyl- or di 1 to 6C-alkyl-amino, or taken together are methylenedioxy, with the proviso that sulfur atoms in R₁ and R₂ cannot have different oxidation states in the same compounds; and pharmaceutically acceptable salts thereof. A compound of claim 1 wherein R₃ is isopropyl and X is oxygen. A compound of Claim 1 or 2 wherein the compound is 6-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide or the sodium salt thereof. A compound of Claim 1 and 2 being a member of the group consisting of 1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide, 1,7-dimethoxy-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide, 5-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide or 7-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide and the sodium salts thereof. A compound of Claim 1 and 2 wherein the compound is 1,7-bis(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide. A pharmaceutical composition containing a compound of Claims 1 to 5 and a pharmaceutically acceptable carrier. Use of a compound of Claims 1 to 5 for the preparation of a pharmaceutical composition useful in the treatment of mammals to inhibit histamine release from basophils. Use of a compound according to Claims 1 to 5 for the preparation of an antiallergy pharmaceutical. Use of a compound according to Claims 1 to 5 for the preparation of an antiinflammatory pharmaceutical. A process for preparing a naphtalene derivative of the formula (I) according to Claim 1 wherein a compound of the formula wherein R₁, R₂ and R₃ are as defined above and is treated with a compound of the formula to obtain the compound of formula I. A process of Claim 10 for preparing a compound of formula I wherein R₃ is isopropyl and X is oxygen. A process of Claim 10 or 11 for preparing a compound of formula I wherein the compound is 6-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphtalenecarboxamide or the sodium salt thereof. A process of Claim 10 and 11 for preparing a compound of formula I being a member of the group consisting of 1-(q-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide, 1,7-dimethoxy-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide, 5-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide or 7-methoxy-1-(1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphthalenecarboxamide and the sodium salts thereof. A process of Claim 10 and 11 for preparing a compound of formula I wherein the compound is 1,7-bis (1-methylethoxy)-N-1H-tetrazol-5-yl-2-naphtalene-carboxamide. Use of a compound manufacture according to Claims 10 to 14 for the preparation of a pharmaceutical useful in the treatment of mammals to inhibit histamine release from basophils. Use of a compound according to Claims 10 to 14 for the preparation of an antiallergy pharmaceutical. Use of a compound according to Claims 10 to 14 for the preparation of an antiinflammatory pharmaceutical. Process for the preparation of a pharmaceutical composition containing a compound prepared according to claims 10 to 14 characterized by combining such compound with a pharmaceutically acceptable carrier.

Inventors: CONNOR, DAVID THOMAS, UNANGST, PAUL CHARLES, WEIKERT, ROBERT JAMES
Applicants: WARNER-LAMBERT COMPANY
Application year: 1988
Main classification: C07D257
IPC codes: A61K31, A61P43, C07D257, A61P37