AZACYCLIC COMPOUNDS AND THEIR PREPARATION AND USE

Abstract: Novel azacyclic compounds selected from the group consisting of wherein R¹ is H or C₁₋₆-alkyl wherein R′ is C₃₋₈-alkyl, cyclopropyl, C₄₋₈-cycloalkyl, benzyl which may be substituted, or C₁₋₄-alkoxy-C₁₋₄-alkyl, and R″ is H or C₁₋₈-alkyl or C₁₋₆-alkoxy or C₁₋₄-alkoxy-C₁₋₄-­ alkyl or aryl, and R‴ is H or C₁₋₆-alkyl or C₄₋₈-cycloalkyl; and R⁴ is H, C₁₋₈-alkyl or Cl; and provided that R³ is not wherein R′ is C₃₋₈-alkyl, cyclopropyl or C₁₋₃-alkoxymethyl, and provided that R³ is not -CH=N-OR‴, wherein R‴ is H or C₁₋₆-alkyl, when the compounds of formula I is and a salt thereof with a pharmaceutically-acceptable acid. The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are useful in the treatment of Alzheimer's disease.

Description: The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease. Due to the in general improved health situation in the western world, elderly-related diseases are much more common now than in the past and are likely to be even more common in the future. One of the elderly-related symptoms is a reduction of the cognitive functions. This symptom is especially pronounced in the pathophysiological disease known as Alzheimer's disease. This disease is combined with, and also most likely caused by, a up to 90% degeneration of the muscarinic cholinergic neurons in nucleus basalis, which is part of substantia innominata. These neurons project to the prefrontal cortex and hippocampus and have a general stimulatory effect on the cognitive functions of the forebrain as well as of hippocampus , namely learning, association, consolidation, and recognition. It is a characteristic of Alzheimer's disease that although the cholinergic neurons degenerate, then the postsynaptic muscarinic receptors in the forebrain and hippocampus still exist. Therefore muscarinic cholinergic agonists are useful in the treatment of Alzheimer's disease and in improving the cognitive functions of elderly people. It is well known that arecoline (methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate) is such a cholinergic agonist. Arecoline however has a very short biological half life and a small separation between central and peripheral muscarinic effects. Furthermore arecoline is a rather toxic compound. Accordingly it is the object of the invention to provide new muscarinic cholinergic compounds. The novel compounds of the present invention are azacyclic or azabicyclic compounds of formula (I) selected from the group consisting of wherein R¹ is H or C₁₋₆-alkyl; and R³ is wherein R' is C₃₋₈-alkyl, cyclopropyl, c₄₋₈-cycloalkyl or benzyl which may be substituted: and R'' is H, C₁₋₈-alkyl, C₁₋₆-alkoxy, C₁₋₄-alkoxy-C₁₋₄-alkyl or aryl; and R⁴ is H, C₁₋₈-alkyl or Cl; and provided that, when the compounds of formula (I) are wherein R¹ is H or C₁₋₆-alkyl; R⁴ is H, C₁₋₆-alkyl or Cl; R³ is wherein R' is C₄₋₆-cycloalkyl or benzyl, which may be substituted; or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable acid, and the following compounds: 1-benzoyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-benzyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methyl-4-chloro-3-methoxyiminomethyl-1,2,5,6-tetraydropyridine, 8-ethoxycarbonyl-3-chloro-2-formyl-8-azabicyclo[3.2.1]oct-2-ene oxime, 1-benzoyl-4-chloro-3-(5-methoxymethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-butyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-hydroxymethyl-3-isoxazlyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-dimethylaminomethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-ethoxy-4,5-dinydro-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-butyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-methoxymethyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 1-benzoyl-4-chloro-3-(5-methyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 3-chloro-2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-eneoxalate, 3-chloro-2-(cyclopropylmethoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, 3-chloro-2-(methoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-ene oxalate, 2-methoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, and 2-ethoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate Examples of such salts include inorganic and organic acid addition salts such as hydrochloride, hydrobromide, sulphate, phosphate, acetate, fumarate, maleate, citrate, lactate, tartrate, oxalate, or similar pharmaceutically-acceptable inorganic or organic acid addition salt. The invention also relates to a method of preparing the above mentioned compounds. This method comprises a) reacting a reactive derivative of a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with a compound having the formula III R'-C(=NOH)NH₂ (III) wherein R' has the meaning defined above to form a compound of the general formula I, wherein R³ is wherein R′ has the meaning defined above, or b) reacting a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with NH₂OH, and reacting the compound thus formed with R′-COCl or (R′CO)₂O, wherein R′ has the meaning set forth above, to form a compound of formula I, wherein R³ is wherein R′ has the meaning defined above, or c) reacting a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with an alkene, alkyne or an equivalent thereof, to form a compound of the general formula I, wherein R³ is wherein R'' has the meaning defined above. The pharmacological properties of the compounds of the invention can be illustrated by determining their capability to inhibit the specific binding of ³H-QNB (³H-quinuclidinyl benzilate) by 50%. The inhibitory effect of a substance on ³H-QNB binding to brain membranes reflects the affinity of the substance for muscarinic acetylcholine receptors. (Yamamura, H.I. and Snyder, S.H., Proc.Natl.Acad.Sci. 71 , 1725-29(1979). The test is carryed out as follows: Fresh whole forebrain from male Wistar rats (200-250 g) is homogenized by an Ultra-Turrax homogenizer (5-10 s) in volumes of 0.32 M sucrose. The homogenate is centrifuged at 4,300 x g for 5 min. The pellet is discarded and the supernatant centrifuged at 40,000 x g for 15 min. The final pellet is rehomogenized in 50 mM KH₂PO₄, pH 7.1 (1000 ml per g of original tissue) and this crude membrane preparation is used for binding assays. To 2.5 ml of tissue suspension is added 25 µl of test solution and 25 µl ³H-QNB (1 nM final concentration). Samples are thoroughly mixed and incubated at 37 o C for 20 min. after incubation, samples are poured directly onto GF/C glass fiber filters under suction and immediately washed 2 times with 10 ml of buffer at 0 o C. Non-specific binding is determined in dublicate using atropin (1 µg/ml, final concentration) as the test substance. The amounts of radioactivity on the filters are determined by conventional liquid scintilation counting. Specific binding is total binding minus non-specific binding. The test value will be given as IC₅₀ (the concentration/µg/ml) of the test substance which inhibits the specific binding of ³H-QNB by 50%). where C o is specific binding in control assays and C x is the specific binding in the test assay (the calculation assumes normal mass-action interaction). The compound of the invention, together with a conventional adjuvant, carrier, or diluent, and if desired in the form of a pharmaceutically-acceptable acid addition salt thereof, may be placed into the form of pharmaceutical compositions and unit dosages thereof, and in such form may be employed as solids, such as tablets or filled capsules, or liquids, such as solutions, suspensions, emulsions, elixirs, or capsules filled with the same, all for oral use, in the form of suppositories for rectal administration; or in the form of sterile injectable solutions for parenteral (including subcutaneous) use. Such pharmaceutical compositions and unit dosage forms thereof may comprise conventional ingredients in conventional proportions, with or without additional active compounds or principles, and such unit dosage forms may contain any suitable effective muscarinic cholinergic agonistic amount of the active ingredient commensurate with the intended daily dosage range to be employed. Tablets containing ten (10) milligrams of the active ingredient or, more broadly, one (1) to hundred (100) milligrams, per tablet, are accordingly suitable representative unit dosage forms. The compounds of this invention can thus be used for the formulation of pharmaceutical preparations, e.g. for oral and parenteral administration to mammals including humans, in accordance with conventional methods of galenic pharmacy. Conventional excipients are such pharmaceutically acceptable organic or inorganic carrier substances suitable for parenteral or enteral application which do not deleteriously react with the active compounds. Examples of such carriers are water, salt solutions, alcohols, polyethylene glycols, polyhydroxyethoxylated castor oil, gelatine, lactose, amylose, magnesium stearate, talc, silicic acid, fatty acid monoglycerides and diglycerides, pentaerythritol fatty acid esters, hydroxymethylcellulose and polyvinylpyrrolidone. The pharmaceutical preparations can be sterilized and mixed, if desired, with e.g. auxiliary agents, emulsifiers, salt for influencing osmotic pressure, buffers and/or coloring substances, which do not deleteriously react with the active compounds. For parenteral application, particularly suitable are injectable solutions or suspensions, preferably aqueous solutions with the active compound dissolved in polyhydroxylated castor oil. Ampoules are convenient unit dosage forms. Tablets, dragees, or capsules having talc and/or a carbohydrate carrier or binder, for instance the carrier preferably being lactose and/or corn starch and/or potato starch, are particularly suitable for oral application. A syrup or elixir, for instance, can be used in cases where a sweetened vehicle can be employed. Generally, the compounds of this invention are dispensed in unit form comprising 1-100 mg in a pharmaceutically acceptable carrier per unit dosage. The dosage of the compounds according to this invention is 1-100 mg/day, preferably 10-70 mg/day, when administered to patients, e.g. humans, as a drug. A typical tablet which may be prepared by conventional tabletting techniques contains: Active compound 5.0 mg Lactosum 67.8 mg Ph.Eur. Avicel® 31.4 mg Amberlite® IRP 88 1.0 mg Magnesii stearas 0.25 mg Ph.Eur. Due to the high muscarinic cholinergic receptor agonistic activity, the compounds of the invention are extremely useful in the treatment symptoms related to a reduction of the cognitive functions of the brain of mammals , when administered in an amount effective for stimulating the cognitive functions of the forebrain and hippocampus. The important stimulating activity of the compounds of the invention includes both activity against the patophysiological disease, Alzheimer's disease as well as against normal degeneration of brain function . The compounds of the invention may accordingly be administered to a subject, e.g., a living animal body, including a human, in need of stimulation of the cognitive functions of the forebrain and hippocampus, and if desired in the form of a pharmaceutically-acceptable acid addition salt thereof (such as the hydrobromide, hydrochloride, or sulfate, in any event prepared in the usual or conventional manner, e.g., evaporation to dryness of the free base in solution together with the acid), ordinarily concurrently, simultaneously, or together with a pharmaceutically-acceptable carrier or diluent, especially and preferably in the form of a pharmaceutical composition thereof, whether by oral, rectal, or parenteral (including subcutaneous) route, in an effective forebrain and hippocampus stimulating amount, and in any event an amount which is effective for improving the cognitive function of mammals due to their muscarinic cholinergic receptor agonistic activity. Suitable dosage ranges are 1-100 milligrams daily, 10-100 milligrams daily, and especially 30-70 milligrams daily, depending as usual upon the exact mode of administration, form in which administered, the indication toward which the administration is directed, the subject involved and the body weight of the subject involved, and the preference and experience of the physician or veterinarian in charge. The invention will now be described in further detail with reference to the following examples: EXAMPLE 1 2-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate Sodium (56.6 mg, 2.46 mmol) was dissolved in absolute ethanol (12 ml). Molecular sieves (Type 4A, 1.3 g) and cyclopropancarboxamide oxime (330 mg, 3.30 mmol) were added and the resulting mixture vigorously stirred for 15 min. before addition of cocaine hydrochloride (280 mg, 0.82 mmol). The reaction mixture was heated at 80 o for 20 hours. The solution was then filtered from the molecular sieves and the solvent was removed in vacuo . Ether (75 ml) was added to the residue followed by water (20 ml) and the organic phase was separated. The aqueous phase was extracted with ether (2x75 ml), and the combined ether phases were dried (MgSO₄, filtered and evaporated. The title compound was isolated as the oxalate, which was recrystallized from absolute ethanol/ether. M.p. 117 o C. In exactly the same manner the following compound was made: 2-(3-n-butyl-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate. M.p. 174 o C. EXAMPLE 2 2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate Sodium (303 mg, 13.2 mmol) was dissolved in absolute ethanol (60 ml). Molecular sieves (Type 4A, 7 g) and isopropancarboxamide oxime (2.64 g, 26.4 mmol) were added and the resulting mixture vigorously stirred for 15 min. before addition of cocaine (2.0 g, 6.6 mmol). The reaction mixture was heated at 80 o for 24 h and at room temperature for 24 h. The solution was then filtered from the molecular sieves and the solvent was removed in vacuo . Ether (250 ml) was added to the residue followed by water (100 ml) and the organic phase was separated. The aqueous phase was extracted with ether (2 x 250 ml), and the combined ether phases were dried (MgSO₄), filtered and evaporated to give an oil, which was chromatographed on silica gel eluting with ethylacetate and ethanol. The title compound was isolated as the oxalate, which was recrystallized from absolute ethanol/ether. M.p. 162 o C. In exactly the same manner the following compounds were made: 2-(3-Methoxymethyl-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate M.p. 139 o C. 2-(3-(2-Methoxyethyl)-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate M.p. 165 o C. EXAMPLE 3 2-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-8-azabicyclo[3.2.1]oct-2-ene hydrochloride 2-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-methyl-8-azabicyclo[3.2.1]oct-2-ene (525 mg, 2.3 mmol) was dissolved in dry dichlorethane (10 ml). The solution was cooled on ice and 1-chloroethyl chloroformate (370 µl, 3.4 mmol was added). The reaction mixture was heated under reflux for 1.5 h and the solvent evaporated. Methanol (20 ml) was added and the mixture heated under reflux for further 1.5 h. The mixture was treated with charcoal, filtered and concentrated in vacuo . The product was recrystallized from absolute ethanol/ether. M.p. 86 o C. In exactly the same manner the following compounds were made: 2-(3-(2-Methoxyethyl)-1,2,4-oxadiazol-5-yl)-8-azabicyclo[3.2.1]oct-2-ene hydrochloride, M.p. 62 o C. 2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-8-azabicyclo[3.2.1]oct-2-ene oxalate, M.p. 168 o C. EXAMPLE 4 3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-2,3-didehydroquinuclidine oxalate Sodium (181 mg, 7.86 mmol) was dissolved in absolute ethanol (45 ml). Molecular sieves (Type 4A, 5 g) and cyclopropancarboxamide oxime (786 mg, 7.86 mmol) were added and the resulting mixture vigorously stirred for 15 min. before addition of 3-methoxycarbonyl-2,3-didehydroquinuclidine, HCl; prepared as described by Grob et al. in Helv . Chim . Acta . (1954), 37 , 1689. The reaction mixture was heated at 80 o C for 18 h. The solution was then filtered from the molecular sieves and the solvent was removed in vacuo . Ether (50 ml) was added to the residue followed by water (25 ml) and the organic phase was separated. The aqueous phase was extracted with ether (3 x 50 ml), and the combined ether phases were dried (Na₂SO₄) and evaporated to give an oil. This material in dichloromethane (50 ml) was treated for 15 min. at 20 o C with potassium t-butoxide (3 g, 26.79 mmol). After filtration, the material isolated from the filtrate was chromatographed on silica gel eluting with ethylacetate-methanol (3.2:1). The title compound was isolated as the oxalate salt. M.p. 189.0 o C. EXAMPLE 5 3-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-quinuclidine oxalate Sodium (224 mg, 9,74 mmol) was dissolved in absolute ethanol (45 ml). Molecular sieves (Type 4A, 5 g) and isopropancarboxamide oxime (993 mg, 9.74 mmol) were added and the resulting mixture vigorously stirred for 15 min. before addition of 3-methoxycarbonyl-quinuclidine, HCl, prepared as described by Grob et al. in Helv . Chim . Acta . (1954), 37 , 1689. The reaction mixture was heated at 80 o C for 18 h. The solution was then filtered from the molecular sieves and the solvent was removed in vacuo . Ether (50 ml) was added to the residue followed by water (25 ml) and the organic phase was separated. The aqueous phase was extracated with ether (3 x 50 ml), and the combined ether phases were dried (Na₂SO₄) and evaporated to afford the title oxadiazole as an oil. The product was further purified as the oxalate salt. M.p. 118-119 o . In exactly the same manner the following compounds were prepared: 3-(3-butyl-1,2,4-oxadiazol-5-yl)-quinuclidine oxalate, M.p. 122-124 o C. 3-(3-methoxymethyl-1,2,4-oxadiazol-5-yl)-quinuclidine oxalate, M.p. 107-108 o C. 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-quinuclidine oxalate, M.p. 156-157 o C. EXAMPLE 6 1-Benzoyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime To a solution of 14.6 g (200 mmol) dimethylformamide in 50 ml methylenechloride at 0 o C was added 24.52 g (160 mmol) phosphorus oxychloride at such a rate that the temperature did not exceed 10 o C. After addition the reaction mixture was stirred for 1 h at room temperature. The mixture was again cooled to 0 o C and 20.32 g (100 mmol) 1-benzoyl-4-piperidone in 30 ml methylenechloride was added dropwise. After addition (30 min.), the reaction mixture was stirred at room temperature for 2 h whereupon, 150 g crushed ice was added and the mixture stirred until the ice had dissolved. Solid sodium acetate (70 g) was added, and the mixture stirred for 15 min. The methylenechloride fraction was isolated and the aqueous portion was extracted with 2 x 50 ml methylenechloride. The combined methylenechloride extracts were poured in 100 ml of a saturated sodium bicarbonate solution, and the mixture stirred vigorously for 15 min. The methylenechloride fraction was then isolated, washed with water, dried over magnesium sulfate and concentrated to a volume of 50 ml. To this solution was added 100 ml ethanol, hydroxylamine hydrochloride (6.65 g, 100 mmol) and 15 ml triethylamine. The reaction mixture was stirred overnight, 200 ml water was added and the methylenechloride fraction isolated. The aqueous portion was extracted with 2 x 50 ml methylenechloride. The combined methylenechloride extracts were dried over magnesiumsulfate, and concentrated in vacuo . To the remaining oil was added 50 ml ethanol and the title compound separated out. Yield: 10.5 g. M.p. 175-176 o C. In exactly the same manner the following compounds were prepared: 1-Methyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime from 1-methyl-4-piperidone and hydroxylamine. M.p. 172-73 o C. 1-Benzyl-4-chloro-3-formyl-1,2,5,6-tetradydropyridine oxime from 1-benzyl-4-piperidone and hydroxylamine. M.p. 148-151 o C. 1-Methyl-4-chloro-3-methoxyiminomethyl-1,2,5,6-tetrahydropyridine from 1-methyl-4-piperidone and O-methylhydroxylamine. M.p. 185-187 o C as oxalate. 8-Ethoxycarbonyl-3-chloro-2-formyl-8-azabicyclo[3.2.1]oct-2-ene oxime from N-(ethoxycarbonyl)nortropan-3-one (G.L. Grunewald et.al. J.Med.Chem. 1988, 31 , 433-44). Oil. EXAMPLE 7 1-Benzoyl-4-chloro-3-(5-methoxymethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine To a solution of 1-benzoyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime (5.3 g, 20 mmol) in 100 ml dry dimethylformamide was added N-bromosuccinimide (4.5 g, 25 mmol) dissolved in 20 ml dry dimethylformamide. The reaction mixture was stirred at room temperature for 1 h. Now methylpropargylether (1.5 ml, 25 mmol) and 2 ml triethylamine was added and the reaction mixture stirred at room temperature overnight. 200 ml water was added and the aqueous phase extracted with 3 x 50 ml ether. The combined ether extracts were washed with 2 x 50 ml water, dried over magnesiumsulfate and concentrated in vacuo . The compound was finally purified by column chromatography with methylenechloride/ethylacetate 4:1 as eluent. Yield: 3.5 g. M.p. 60.5-62 o C. In exactly the same manner the following compounds were prepared 1-Benzoyl-4-chloro-3-(5-butyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine 1-Benzoyl-4-chloro-3-(5-hydroxymethyl-3-isoxasolyl)-1,2,5,6-tetrahydropyridine 1-Benzoyl-4-chloro-3-(5-dimethylaminomethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine 1-Benzoyl-4-chloro-3-(5-ethoxy-4,5-dihydro-3-isoxazolyl)-1,2,5,6-tetrahydropyridine 8-Ethoxycarbonyl-3-chloro-2-(5-butyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene 8-Ethoxycarbonyl-3-chloro-2-(5-methoxymethyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene 8-Ethoxycarbonyl-3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oxt-2-ene 1-Benzoyl-4-chloro-3-(5-methyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine To a solution of 1-benzoyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime (5,3 g, 20 mmol) in 100 ml dry dimethylformamide was added N-bromosuccinimide (4.5 g, 25 mmol) dissolved in 20 ml dry dimethylformamide. The reaction mixture was stirred at room temperature for 1 h. Now 2-bromopropene (2.2 ml, 25 mmol) and 4 ml triethylamine were added and the reaction mixture stirred at room temperature for 48 h. The compound was purified as described for 1-Benzoyl-4-chloro-3-(5-methoxymethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine. Yield: 3.1 g. M.p. 86-87 o C. In exactly the same manner the following compound was prepared 8-Ethoxycarbonyl-3-chloro-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene EXAMPLE 8 3-(5-Propyl-1,2,4-oxadiazol-3-yl)-2,3-didehydroquinuclidine oxalate To a solution of sodium (575 mg, 25 mmol) in methanol (20 ml) was added a solution of hydroxylamine hydrochloride (1.55 g, 22 mmol) in methanol (20 ml). The mixture was stirred for 30 min, and filtrated. To the filtrate a solution of 3-cyano-2,3-didehydroquinuclidine (Helv.Chem.Acta 40 , 2170 (1957)) (1.2 g, 9 mmol) in methanol (5 ml) was added and the reaction mixture was stirred at room temperature for 48 h. After evaporation the residue was suspended in absolute ethanol (25 ml), filtered and evaporated to give the 2,3-didehydroquinuclidineamide oxime. The amide oxime (700 mg) was dissolved in butyric anhydride and stirred at 100 o C for 16 h. After evaporation the residue was dissolved in a saturated potassium carbonate solution (10 ml) and extracted with ether (3x75 ml). The combined organic phases were dried and evaporated. The residue was purified (column chromatography with 1,2-dichloroethane-methanol (9:1) as eluent). Crystallization as the oxalate salt from acetone gave the title compound in a 300 mg yield. M.p. 155-157 o C. 3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-didehydroquinuclidine oxalate This compound was synthesized as described above using cyclopropanecarboxylic acid chloride followed by cyclization in refluxing toluene instead of butyric anhydride. M.p. 170-172 o C. 8-Methyl-2-(5-propyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]oct-2-ene oxalate This compound was synthesized as described above starting from 2-cyano-8-methyl-8-azabicyclo[3.2.1]oct-2-ene [J.C.S. Perkin I, 1981, 1346-1351]. M.p. 99-101 o C. EXAMPLE 9 3-Chloro-2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate To a dimethylformamide (4.5 ml, 60 mmol) at 0 o C was added phosphorous oxychloride (3 ml, 30 mmol). Tropinone (2 g, 13 mmol) was added, and the reaction mixture heated to 70 o C for ½ h. After cooling, crushed ice was added and then solid potassium carbonate until alkaline reaction. The water solution was extracted with ether (3x30 ml). The ether extracts were dried and evaporated. The crude compound was purified by column chromatography with acetone as eluent. The title compound was precipitated with a 1M oxalic acid acetone solution, filtered and dried. M.p. 136-137 o C decomposes. EXAMPLE 10 3-Chloro-2-(cyclopropylmethoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate To a solution of 3-chloro-2-formyl-8-methyl-8-azabicyclo-[3.2.1]oct-2-ene oxalate (0.55 g, 2 mmol) in 20 ml ethanol cyclopropylmethoxyamine hydrochloride (0.25 g, 2 mmol) and triethylamine (1 ml) was added. The reaction mixture was stirred at room temperature for 1 h, then evaporated in vacuo . 20 ml sodiumhydroxide solution (0.5M) was added to the residue, and the solution was extracted with methylenechloride (3x15 ml). The combined methylenechloride extracts were dried and evaporated in vacuo . The residue was dissolved in acetone (10 ml) and the title compound was precipitated with a 1M oxalic acid acetone solution. The compound was filtered and dried. M.p. 170-171 o C. In exactly the same manner the following compound was prepared: 3-Chloro-2-(methoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate from 3-chloro-2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate and methoxyamine hydrochloride, M.p. 180-185 o C. EXAMPLE 11 3-Chloro-8-methyl-2-(5-oxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate To a solution of 3-chloro-2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate (0.55 g, 2 mmol) in 20 ml methanol powdered potassium carbonate (1.5 g) and tosylmethylisocyanide (0.4 g, 2 mmol) was added. The reaction mixture was stirred at room temperature for 2 h. Upon evaporation in vacuo water (30 ml) was added to the residue and the water solution extracted with methylenechloride (3x20 ml). The combined methylenechloride extracts were dried and evaporated in vacuo . The residue was dissolved in ethanol, and the title compound precipitated with a 1M oxalic acid ether solution. The compound was filtered and dried. M.p. 69-71 o C decomposes. EXAMPLE 12 2-Methoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate To a solution of 2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene (T. Bacesov and M. Shives, J.Am.Chem.Soc., 107 , 7524-33, 1985) (0.3 g, 2 mmol) in 20 ml ethanol methoxyamine hydrochloride (0.17 g, 2 mmol) and triethylamine 0.5 ml was added. The reaction mixture was stirred at room temperature for 1 h, then evaporated in vacuo . Sodiumhydroxide solution (20 ml, 0.5 mmol) was added to the residue and the solution was extracted with methylenechloride (3x15 ml). The combined methylenechloride extracts were dried and evaporated in vacuo . The residue was dissolved in acetone (5 ml) and the title compound was precipitated with a 1M oxalic acid acetone solution. The compound was filtered and dried. M.p. 129-130 o C. In exactly the same manner the following compound was prepared: 2-Ethoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate from 2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene and ethoxyamine hydrochloride. M.p. 127-128 o C. EXAMPLE 13 3-(3-Cyclobutyl-1,2,4-oxadiazol-5-yl)-1-methyl-1,2,5,6-tetrahydropyridine oxalate To a solution of sodium ethoxide (prepared from sodium (34 mg, 1.48 mmol), destilled ethanol (20 ml) and molecular sieves (4 g) was added cyclobutancarboxamide oxime (169 mg, 1.48 mmol). The mixture was stirred at room temperature for 10 min. and arecoline, hydrobromide (175 mg, 0.74 mmol) was added. The reaction mixture was stirred at 80 o C for 18 h, filtered and evaporated. Water (10 ml) was added to the residue, and the solution was extracted with ether (3x30 ml). The combined ether phases were dried and evaporated to give the crude product as an oil. Crystallization as the oxalate salt from absolute ethanol gave the title compound in a yield of 60 mg. M.p. 148-149 o C. In exactly the same manner the following compounds were prepared: 3-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-1-methyl-1,2,5,6-tetrahydropyridine oxalate. M.p. 132-133 o C. 3-(3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl)-1-methyl-1,2,5,6-tetrahydropyridine oxalate. M.p. 140-141 o C. 3-(3-(2-ethoxyethyl)-1,2,4-oxadiazol-5-yl)-1-methyl-1,2,5,6-tetrahydropyridine oxalate. M.p. 143-144 o C. 3-(3-(2-methoxybenzyl)-1,2,4-oxadiazol-5-yl)-1-methyl-1,2,5,6-tetrahydropyridine oxalate. M.p. 76-77 o C. Using norarecoline instead of arecoline the following compounds were made in exactly the same manner as described above: 3-(3-cyclobutyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine oxalate. M.p. 202-205 o C. 3-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine oxalate. M.p. 152-158 o C. EXAMPLE 14 3-Chloro-2-(5-butyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate To a solution of 1.0 g (3 mmol) of 8-ethoxycarbonyl-3-chloro-2-(5-butyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene in dry toluene (20 ml), 2 g (15 mmol) aluminiumtrichloride was added. The reaction mixture was heated at 70 o C for 15 min., then cooled and poured on ice water (100 ml). The phases were separated and the water phase extracted with 2 x 20 ml ethylether. The water phase was made alkaline with a sodiumhydroxide solution (2 N), and extracted with 3 x 30 ml methylenchloride. The organic phase was dried over magnesiumsulphate and concentrated in vacuo . Crystallization as the oxalate salt from acetone gave the title compound in a 450 mg yield. M.p. 112-114 o C. In exactly the same manner the following compounds were prepared: 3-Chloro-2-(5-methoxymethyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate. M.p. 153-154 o C. 3-Chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate. M.p. 135-136 o C. 3-Chloro-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate. M.p. 136-137°C. 2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate. M.p. 163-164 o C. EXAMPLE 15 8-Ethoxycarbonyl-2-(5-phenyl-3-isoxasolyl)-8-azabicyclo[3.2.1]oct-2-ene 1.3 g (3.6 mmol) 8-ethoxycarbonyl-3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene was dissolved in 30 ml ethanol. 300 mg Pd/C 5%, triethylamine (7 ml) and formic acid (3 ml) was added and the reaction mixture heated at reflux for 4 h. The mixture was concentrated in vacuo , water (50 ml) was added and the solution extracted with ethylether 3 x 20 ml. The organic phase was dried over magnesiumsulphate and concentrated in vacuo . The crude product was purified by column chromatography with methylenchloride/ethylacetate (9:1) as eluent. Yield 600 mg oil. EXAMPLE 16 To a mixture of formic acid (5 ml) and formaldehyde 37% (10 ml) 5 mmole of (1) 3-chloro-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate and (2) 3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate, was added. The reaction mixture was heated at reflux for 1 h. After cooling the reaction mixture was poured on water (50 ml) and made alkaline with solid potassiumcarbonate. The water phase was extracted with 3 x 30 ml methylenchloride. The organic phases were dried over magnesiumsulphate and concentrated in vacuo . Crystallization as the oxalate salt from acetone gave the following compounds: (1) 3-Chloro-8-methyl-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate with 3-chloro-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate as starting compound. M.p. 149-150 o C. (2) 3-Chloro-8-methyl-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate with 3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate as starting compound. M.p. 260-261 o C.

Claims: Claims for the following Contracting States : DE, GB, FR, IT, NL, SE, LI, CH, BE, AT, LU An azacyclic or azabicyclic compound of formula (I) selected from the group consisting of wherein R¹ is H or C₁₋₆-alkyl; and R³ is wherein R' is C₃₋₈-alkyl, cyclopropyl, C₄₋₈-cycloalkyl or benzyl which may be substituted; and R'' is H, C₁₋₈-alkyl, C₁₋₆-alkoxy, C₁₋₄-alkoxy-C₁₋₄-alkyl or aryl; and R⁴ is H, C₁₋₈-alkyl or Cl: and provided that, when the compounds of formula (I) are wherein R¹ is H or C₁₋₆-alkyl; R⁴ is H, C₁₋₆-alkyl or Cl; R³ is wherein R' is C₄₋₆-cycloalkyl or benzyl, which may be substituted; or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable acid, and the following compounds: 1-benzoyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-benzyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methy1-4-chloro-3-methoxyiminomethyl-1,2,5,6-tetraydropyridine, 8-ethoxycarbonyl-3-chloro-2-formy1-8-azabicyclo[3.2.1]oct-2-ene oxime, 1-benzoyl-4-chloro-3-(5-methoxymethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-butyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-hydroxymethyl-3-isoxazlyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-dimethylaminomethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-ethoxy-1,5-dihydro-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-butyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-methoxymethyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 1-benzoyl-4-chloro-3-(5-methyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-methy1-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 3-chloro-2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene-oxalate, 3-chloro-2-(cyclopropylmethoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, 3-chloro-2-(methoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-ene oxalate, 2-methoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, and 2-ethoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate 3-chloro-8-methyl-2-(5-oxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate. A compound of claim 1 which is 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene, A compound of claim 1 which is 3-(5-propyl-1,2,4-oxadiazol-3-yl)-2,3-didehydroquinuclidine. A compound of claim 1 which is 3-(3-butyl-1,2,4-oxadiazol-5-yl)-quinuclidine. A method of preparing a compound of general formula (I), characterized in a) reacting a reactive derivative of a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with a compound having the formula(III) R'-C(=NOH)NH₂ (III) wherein R' has the meaning defined above to form a compound of the general formula I, wherein R³ is wherein R' has the meaning defined above, or b) reacting a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with NH₂OH, and reacting the compound thus formed with R'-COCl or (R'CO)₂O, wherein R' has the meaning set forth above, to form a compound of formula I, wherein R³ is wherein R' has the meaning defined above, or c) reacting a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with an alkene, alkyne or an equivalent thereof, to form a compound of the general formula I, wherein R³ is wherein R'' has the meaning described above. A pharmaceutical composition comprising an effective amount of a compound of any of claims 1 to 4 together with a pharmaceutically acceptable carrier or diluent. The pharmaceutical composition according to claim 6 which is in the form of an oral dosage unit containing 1-100 mg of the active compound. Use of a compound of any of claims 1 to 4 for the preparation of a medicament useful in stimulating the cognitive functions of the forebrain and hippocampus of mammals, including humans, and therefore in treating Alzheimer's disease in the same. Claims for the following Contracting State : ES A method of (i) preparing an azacylic or azabicyclic compound of formula (I) selected from the group consisting of wherein R¹ is H or C₁₋₆-alkyl; and R³ is wherein R' is C₃₋₈-alkyl, cyclopropyl, C₄₋₈-cycloalkyl or benzyl which may be substituted; and R'' is H, C₁₋₈-alkyl, C₁₋₆-alkoxy, C₁₋₄-alkyl-C₁₋₄-alkyl or aryl: and R⁴ is H, C₁₋₈-alkyl or Cl; and provided that, when the compounds of formula (I) are wherein R¹ is H or C₁₋₆-alkyl; R⁴ is H, C₁₋₆-alkyl or Cl; R³ is wherein R' is C₄₋₈-cycloalkyl or benzyl, which may be substituted; or a pharmaceutically acceptable salt thereof, characterized in a) reacting a reactive derivative of a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with a compound having the formula(III) R'-C(=NOH)NH₂ (III) wherein R' has the meaning defined above to form a compound of the general formula I, wherein R³ is wherein R' has the meaning defined above, or b) reacting a compound selected from the group consisting of and (ii) preparing the compounds: 1-benzoyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-benzyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methyl-4-chloro-3-methoxyiminomethyl-1,2,5,6-tetraydropyridine, 8-ethoxycarbonyl-3-chloro-2-formyl-8-azabicyclo[3.2.1]oct-2-ene oxime, 1-benzoyl-4-chloro-3-(5-methoxymethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-butyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-hydroxymethyl-3-isoxazlyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-dimethylaminomethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-ethoxy-4,5-dihydro-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-butyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-methoxymethyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 1-benzoyl-4-chloro-3-(5-methyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 3-chloro-2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene-oxalate, 3-chloro-2-(cyclopropylmethoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, 3-chloro-2-(methoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-ene oxalate, 2-methoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, and 2-ethoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate 3-chloro-8-methyl-2-(5-oxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate. according to the procedure outlined in the working examples. The method of claim 1, wherein the compound of formula (I) is 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene. The method of claim 1, wherein the compound of formula (I) is 3-(5-propyl-1,2,4-oxadiazol-3-yl)-2,3-didehydroquinuclidine. The method of claim 1, wherein the compound of formula (I) is 3-(3-butyl-1,2,4-oxadiazol-5-yl)-quinuclidine. Use of a compound prepared according to the method of claim 1 for the preparation of a medicament useful in stimulating the cognitive functions of the forebrain and hippocampus of mammals, including humans, and therefore in treating Alzheimer's disease in the same. A process for preparing a pharmaceutical composition which comprises mixing a compound prepared according to the method of any of claims 1 to 4 with a pharmaceutically acceptable carrier or diluent. Claims for the following Contracting State : GR An azacyclic or azabicyclic compound of formula (I) selected from the group consisting of wherein R¹ is H or C₁₋₆-alkyl; and R³ is wherein R' is C₃₋₈-alkyl, cyclopropyl, C₄₋₈-cycloalkyl or benzyl which may be substituted; and R'' is H, C₁₋₈-alkyl, C₁₋₆-alkoxy, C₁₋₄-alkoxy-C₁₋₄-alkyl or aryl; and R⁴ is H, C₁₋₈-alkyl or Cl; and provided that, when the compounds of formula (I) are wherein R¹ is H or C₁₋₆-alkyl; R⁴ is H, C₁₋₆-alkyl or Cl; R³ is wherein R' is C₄₋₆-cycloalkyl or benzyl, which may be substituted; or a pharmaceutically acceptable salt thereof with a pharmaceutically acceptable acid, and the following compounds: 1-benzoyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-benzyl-4-chloro-3-formyl-1,2,5,6-tetrahydropyridine oxime, 1-methyl-4-chloro-3-methoxyiminomethyl-1,2,5,6-tetraydropyridine, 8-ethoxycarbonyl-3-chloro-2-formyl-8-azabicyclo[3.2.1]oct-2-ene oxime, 1-benzoyl-4-chloro-3-(5-methoxymethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-butyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-hydroxymethyl-3-isoxazlyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-dimethylaminomethyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 1-benzoyl-4-chloro-3-(5-ethoxy-4,5-dihydro-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-butyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-methoxymethyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 8-ethoxycarbonyl-3-chloro-2-(5-phenyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 1-benzoyl-4-chloro-3-(5-methyl-3-isoxazolyl)-1,2,5,6-tetrahydropyridine, 8-ethoxycarbonyl-3-chloro-2-(5-methyl-3-isoxazolyl)-8-azabicyclo[3.2.1]oct-2-ene, 3-chloro-2-formyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene-oxalate, 3-chloro-2-(cyclopropylmethoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, 3-chloro-2-(methoxyiminomethyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-ene oxalate, 2-methoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate, and 2-ethoxyiminomethyl-8-methyl-8-azabicyclo[3.2.1]oct-2-ene oxalate 3-chloro-8-methyl-2-(5-oxazolyl)-8-azabicyclo[3.2.1]oct-2-ene oxalate, A compound of claim 1 which is 2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene, A compound of claim 1 which is 3-(5-propyl-1,2,4-oxadiazol-3-yl)-2,3-didehydroquinuclidine. A compound of claim 1 which is 3-(3-butyl-1,2,4-oxadiazol-5-yl)-quinuclidine. A method of preparing a compound of general formula (I), characterized in a) reacting a reactive derivative of a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with a compound having the formula(III) R'-C(=NOH)NH₂ (III) wherein R' has the meaning defined above to form a compound of the general formula I, wherein R³ is wherein R' has the meaning defined above, or b) reacting a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with NH₂OH, and reacting the compound thus formed with R'-COCl or (R'CO)₂O, wherein R' has the meaning set forth above, to form a compound of formula I, wherein R³ is wherein R' has the meaning defined above, or c) reacting a compound selected from the group consisting of wherein R¹, R⁴ and have the meanings defined above, with an alkene, alkyne or an equivalent thereof, to form a compound of the general formula I, wherein R³ is wherein R'' has the meaning described above. Use of a compound of any of claims 1 to 4 for the preparation of a medicament useful in stimulating the cognitive functions of the forebrain and hippocampus of mammals, including humans, and therefore in treating Alzheimer's disease in the same. A process for preparing a pharmaceutical composition which comprises mixing a compound of any of claims 1 to 4 with a pharmaceutically acceptable carrier or diluent.

Inventors: KINDTLER, JENS W., NIELSEN, LONE, OLESEN, PREBEN HOULBERG, SAUERBERG, PER, WAETJEN, FRANK, Wätjen, Frank 
Applicants: NOVO NORDISK A/S
Application year: 1988
Main classification: C07D451
IPC codes: C07D451, A61K31, C07D211, C07D413, A61P25, C07D453