Gas-phase fluorination process

Abstract: An improved gas-phase process for the manufacture of 1,1,1-trifluorodichloroethane and 1,1,1,2-­ tetrafluorochloroethane by contacting a suitable tetrahaloethylene with hydrogen fluoride in the presence of a selected metal on a high fluorine content alumina support, the reaction being conducted under controlled conditions whereby the production of pentafluoroethane is minimized.

Description: An improved process for the manufacture of 1,1,1-trifluorodichloroethane (FC-123) and 1,1,1,2-tetrafluorochloroethane (FC-124), more particularly, a gas-phase reaction of a suitable tetrahaloethylene with hydrogen fluoride in the presence of a selected metal on a high fluorine content alumina support, the reaction being conducted under controlled conditions whereby the production of pentafluoroethane is minimized. Canadian Patent No. 1,196,345 describes a process for the preparation of CF 3 CHXY (X = H, F; Y = H, F, Cl, Br, I) by addition of HF to the corresponding ethylene in the presence of chromium oxyfluoride at 20-200°C, especially 60-180°C. U.S. 3,755,477 describes a process for producing fluorinated aliphatic hydrocarbons which comprises fluorinating a halogenated aliphatic hydrocarbon, including tetrachloroethylene and chlorotrifluoroethylene, by reaction in the gas phase with hydrogen fluoride in the presence of a steam-treated and calcined chromium oxide catalyst prepared by a multi-step process. Example 23, col. 5, shows tetrachloroethylene as a raw material with formation of CF 3 CHCl 2 (20%), CF 3 CHClF (20%), CF 3 CHF 2 (30%), and CF 3 CClF 2 (20%) at 10/1 HF/C 2 Cl 4 mol ratio, 5.4 seconds contact time and 360°C reaction temperature. Example 24, col. 5, shows chlorotrifluoroethylene as a raw material with formation of CF 2 =CF 2 (20%) and CF 3 CHClF (13%) at 1.8/1 HF/C 2 ClF 3 mol ratio, 4 seconds contact time and 320°C reaction temperature. In these examples, less desirable pentafluorinated products are obtained in a greater amount than the desired tri- and tetrafluoro products. U.S. 3,258,500 describes a process for the catalytic vapor phase reaction of HF with halohydrocarbons, including tetrachloroethylene including chlorotrifluoroethylene, employing a catalyst that consists essentially of a heat-activated anhydrous chromium (III) okide which may be supported on alumina. This catalyst is highly active. Example 17, col. 14, shows fluorination of tetrachloroethylene with this catalyst, like that of the above 417 patent, produces large quantities of the less desirable highly fluorinated pentafluoroethane. At 400°C the product distribution is 35.0% pentafluoroethane, 9.2% 1-chloro-1,2,2,2-tetrafluoroethane, and 3.5% 1,1-dichloro-2,2,2-trifluoroethane. At 300°C the product distribution is 38.3% 1-chloro-1,2,2,2-tetrafluoroethane, 25.4% pentafluoroethane, and 16.0% 1,1-dichloro-2,2,2-trifluoroethane. Example 20, col.15, shows chlorotrifluoroethylene yields CF 3 CHF 2 as the major product at 400°C. GB 1,000,485 describes a process for the preparation of organic fluorinated compounds by fluorination of halo-olefins in the gaseous phase and at a temperature preferably within the range 200°C to 400°C. The catalyst consists essentially of partially fluorinated alumina impregnated with one or more polyvalent metal halides. The polyvalent metal may be chromium, cobalt, nickel, or manganese. The total content of polyvalent metal halide expressed as oxide is not more than 15% by weight of the partially fluorinated (70-80%) alumina expressed as alumina. Example 4, (Table 4) shows reaction of tetrachloroethylene with HF over such catalyst yields CF- 3 CHCl 2 as the major product at 220-290°C. In addition, the patent states that if fluorination of the catalyst is excessive, the activity of the catalyst is impaired (page 3, column 2, lines 85-87). The references do not disclose how to produce selectively both 1,1,1-trifluorochloroethane and 1,1,1,2-tetrafluorochloroethane while minimizing the production of the pentafluoroethanes, especially at high tetrahaloethylene conversions. The process of the instant invention achieves the desired high degree of selectivity by minimizing the formation of the pentafluoroethane, through catalyst selection and control of the reaction variables as discussed below and illustrated in the Examples. What has been discovered is a process for the preparation of 1,1,1 -trifluorodichloroethane and 1,1,1,2-tetrafluorochloroethane by fluorination of a tetrahaloethylene, C 2 Cl 4-x F x , wherein x = 0 to 3, comprising contacting in the gaseous phase at 300°C to 450°C said tetrahaloethylene and HF with a catalyst comprising a metal in an oxidation state greater than zero, said metal selected from the group consisting of chromium, manganese, nickel, and cobalt, and mixtures thereof, on a support consisting essentially of aluminum, oxygen, and fluorine in such proportions that the support contains AlF 3 in an amount of at least 90% by weight of the catalyst composition exclusive of the metal, said AlF 3 content being obtained by pretreatment of alumina impregnated with at least one compound of the metal with HF. The tetrahaloethylene of this invention defined by the formula C 2 Cl 4-x F x , wherein x = 0 to 3, includes CCl 2 =CCl 2 , CCIF=CCl 2 , CCIF=CCIF, CF 2 =CCI 2 , and CF 2 =CCIF, and mixtures of these. Tetrachloroethylene is preferred. By a high fluorine content alumina support is meant a composition comprising aluminum, oxygen and fluorine in such proportions that the total fluorine content of the catalyst composition taken as AlF 3 corresponds to at least 90 weight percent, exclusive of the supported metal, preferably 95 weight percent AlF 3 or more. The remainder of the support may include alumina or aluminum oxyfluoride. The high AlF 3 content support can be prepared in-situ by exhaustive fluorination of alumina impregnated with at least one chromium, manganese, nickel, or cobalt compound which may be in the form of the oxide, oxyhalide, halide or pseudohalide or such other form which is convertible to the fluoride or oxyfluoride under the conditions of the HF pretreatment step described herein. The halides include fluorides, chlorides, or bromides. The pseudohalides include cyanides, cyanates and thiocyanates. The preferred metals are manganese, nickel and cobalt. The most preferred metal is cobalt. The total content of chromium, manganese, nickel, or cobalt expressed as the divalent oxide is not more than 20% by weight of the supported catalyst. The catalyst of the instant invention can be prepared prior to reaction with the tetrahaloethylene, by impregnating Al 2 O 3 with the desired metal compound and treatment with HF at elevated temperatures until the desired degree of fluorination is obtained, e.g., at about 200 degrees Centigrade to about 450 degrees Centigrade. The treatment with HF can conveniently be done in the reactor which is to be used for contacting tetrachloroethylene with HF. A suitable catalyst may be prepared, for example, as follows: A quantity of Al 2 O 3 is impregnated with a solution of a catalytically effective amount of one or more metal halides or pseudohalides of chromium, manganese, nickel, or cobalt. By catalytically effective amount is meant an amount of the metal expressed as the divalent oxide between 0.02 to 20 weight percent of the alumina support, preferably 0.1 to 5 weight percent The impregnated Al 2 O 3 can be dried until essentially all moisture is removed, e.g., for about 18 hours at about 100°C. The dried catalyst is then transferred to the reactor to be used. The temperature is then gradually increased to about 400°C while maintaining a flow of N 2 through the reactor to remove any remaining traces of moisture from the catalyst and the reactor. The temperature is then lowered to about 200°C and HF diluted with N 2 is passed through the reactor. The N 2 can be gradually reduced until only HF is being passed through the reactor. At this point the temperature can be increased to about 450°C and held at that temperature to convert the impregnated Al 2 O 3 to a fluoride content corresponding to at least 90% AlF 3 , e.g., for 15 to 300 minutes, depending on the HF flow and the catalyst volume. The reaction of the tetrahaloethylene with HF in the presence of the catalyst of the instant invention is conducted at 300°C to 450°C, preferably about 300°C to 400°C, and most preferably about 325°C to 350°C, with a contact time of 5 to 100 seconds, preferably about 10 to 90 seconds, and most preferably about 15 to 60 seconds. The molar ratio of HF to the tetrahaloethylene can range from 1/1 to 20/1, preferably about 3/1 to 10/1, and most preferably about 4/1 to 7/1. In general, with a given catalyst composition, the higher the temperature, the greater the HF/tetrahaloethylene mol ratio, and the longer the contact time, the greater is the conversion of the tetrahaloethylene to fluorinated products. The above variables can be balanced, one against the other, so that formation of FC-123 is favored over FC-124 and the production of these two compounds taken together is maximized and that of higher fluorinated products minimized. A key feature of the invention is that through catalyst selection and process control, as described herein, the desired tri- and tetrafluoro products can be obtained as the major products at high tetrahaloethylene conversions, normally between 30% and 90%. Preferably, the reaction variables are controlled so as to keep the production of the pentafluoro product below 10 area percent, as determined gas chomatographically, of the products produced. Thus, as illustrated in the examples with tetrachloroethylene, the tri- and tetrafluoro products are obtained in very high yields while minimizing the production of higher fluorinated products even at high conversions of tetrachloroethylene. Intermediates formed during the course of the reaction, such as CHF 2 CCIF 2 , CHCIFCCIF 2 , CHCI 2 CCIF 2 , CCIF=CCl 2 , and CHCI 2 CCI 2 F, can be recycled to the reactor for the production of additional FC-123 and FC-124. In addition, FC-123 can be recycled to the reactor for the production of additional FC-124 when this is desired. The reaction of the tetrahaloethylene with HF may be conducted in any suitable reactor, including fixed and fluidized bed reactors. The reaction vessel should be constructed from materials which are resistant to the corrosive effects of hydrogen fluoride such as Hastelloy and Inconel. Pressure is not critical. Atmospheric and superatmospheric pressures are the most convenient and are therefore preferred. The fluorinated alkanes produced by the invention have utility as blowing agents and refrigerants. They can also be used as starting materials for the preparation of other useful compounds. For example, FC-124 can be used to prepare 1,1,1,2-tetrafluoroethane. In the following illustrative examples, all parts and percentages are by weight and all temperatures are Centigrade unless otherwise stated. All reactions used commercial HF containing only trace amounts of water. General Procedure for Fluorination The reactor (a 12.7mm (0.5 inch) ID, 305mm (12 inch) long Inconel pipe) was charged with the amount of catalyst as described in the following examples, and placed in a sand bath. The bath was gradually heated to 400° while nitrogen gas at a flow rate of 50 ml/minute was passed through the reactor to remove traces of water. The temperature was lowered to 200° and HF and nitrogen gas (1:4 molar ratio) were passed through the reactor and the nitrogen flow was decreased with time until neat HF was being passed through the reactor. At this point, the temperature was gradually raised to 450° and maintained there for 15 to 300 minutes. The fluorine content of the catalyst composition corresponded to an AlF 3 content, exclusive of the metal, of at least 95%. The temperature was then decreased to the indicated values and, thereafter, CCI 2 =CCI 2 flow was started. The flows of HF and CCl 2 =CCl 2 were adjusted to give the indicated molar ratios and contact times. The reactor effluent was scrubbed with aqueous potassium hydroxide to remove HCI and HF and sampled on-line with a Hewlett Packard HP 5890 gas chromatograph using a 6.1m (20 foot) long, 3.18mm (one-eighth inch) diameter, column containing "Krytox" perfluorinated polyether on an inert support and a helium flow of 35 cc/minute. Gas chromatographic conditions were 70° for 3 minutes followed by temperature programming to 180° at a rate of 6°/minute. EXAMPLES 1 - 2 The General Procedure for Fluorination was followed using 19.8 g. (30 cc) of NiCl 2 /Al 2 O 3 (2% NiCl 2 ) as the initial catalyst charge. The results of the reaction of HF with CCl 2 =CCl 2 over the prepared catalyst are given in Table 1. Example 1 2 Temp. °C 325 350 HF/C 2 Cl 4 (mol ratio) 5/1 6/1 Contact Time (sec.) 45 30 Conversion % 58.7 61.2 Area Percent CF 3 CHCl 2 70.0 60.6 CF 3 CHClF 12.4 20.3 CF 3 CHF 2 0.5 1.3 CF 3 CHCl 2 plus CF 3 CHClF 82.4 80.9 EXAMPLES 3 - 4 The General Procedure for Fluorination was followed using 19.5 g. (30 cc) of MnCl 2 /Al 2 O 3 (1.87% MnCl 2 ) as the initial catalyst charge. The results of the reaction of HF with CCI 2 =CCI 2 over the prepared catalyst are given in Table 2. Example 3 4 Temp. °C 350 375 HF/C 2 Cl 4 (mol ratio) 6/1 10/1 Contact Time (sec.) 30 25 Conversion % 70.4 61.5 Area Percent CF 3 CHCl 2 67.8 58.5 CF 3 CHClF 18.5 17.6 CF 3 CHF 2 1.0 1.1 CF 3 CHCl 2 plus CF 3 CHClF 86.3 76.1 EXAMPLES 5 - 9 The General Procedure for Fluorination was followed using 18.4 g. (30 cc) of CoCl 2 /Al 2 O 3 (2.0% CoCl 2 ) as the initial catalyst charge. The results of the reaction of HF with CCl 2 =CCl 2 over the prepared catalyst are given in Table 3. Example 5 6 7 8 9 Temp. °C 350 350 350 350 350 HF/C 2 Cl 4 (mol ratio) 7/1 10/1 5/1 5/1 3/1 Contact Time (sec.) 13.2 19.3 31.8 17.6 25.7 Conversion % 87.3 90.3 86.8 75.7 60.0 Area Percent CF 3 CHCl 2 56.5 52.8 53.6 57.8 52.1 CF 3 CHClF 37.2 41.1 39.4 32.2 32.9 CF 3 CHF 2 1.6 2.1 2.2 1.5 2.5 CF 3 CHCl 2 plus CF 3 CHClF 93.7 93.9 93.0 90.0 85.0 EXAMPLES 10-13 The General Procedure for Fluorination was followed using 20.4 g. (30 cc) of CrCl 3 /Al 2 O 3 (5.2% CrCl 3 on Al 2 O 3 ) as the initial catalyst charge. The results of the reaction of HF with CCl 2 =CCl 2 over the prepared catalyst are given in Table 4. Example 10 11 12 13 Temp. °C 425 350 350 350 HF/C 2 Cl 4 (mol ratio) 4/1 4/1 5/1 6/1 Contact Time (sec.) 15 60 60 60 Conversion % 62.1 78.3 78.1 80.3 Area Percent CF 3 CHCl 2 31.4 50.8 49.6 46.1 CF 3 CHClF 22.2 28.5 29.7 33.3 CF 3 CHF 2 9.8 6.9 7.3 7.2 CF 3 CHCl 2 plus CF 3 CHClF 53.6 79.3 79.3 79.4

Claims: Claims for the following Contracting States : CH, DE, ES, FR, GB, LI, NL, SE, IT A process for the preparation of 1,1,1 -trifluorodichloroethane and 1,1,1,2-tetrafluorochloroethane by fluorination of a tetrahaloethylene, C 2 Cl 4-x F x , wherein x = 0 to 3, comprising contacting in the gaseous phase at 300°C to 450°C said tetrahaloethylene and HF with a catalyst comprising at least one metal in an oxidation state greater than zero, said metal selected from the group consisting of chromium, manganese, nickel and cobalt, wherein in the case of chromium it is present in the form of chromium fluoride or chromium oxyfluoride, on a support comprising aluminium, oxygen and fluorine in such proportions that the support contains AlF 3 in an amount of at least 90% by weight of the catalyst composition exclusive of the metal, said AlF 3 content being obtained by pre-treatment of alumina impregnated with at least one compound of the metal with HF. A process as claimed in claim 1 wherein the tetrahaloethylene is tetrachloroethylene. A process as claimed in claim 1 or claim 2 wherein the catalyst contains 0.02 to 20 weight percent of metal expressed as the divalent oxide. A process as claimed in claim 3 wherein the catalyst contains 0.1 to 5 weight percent of metal expressed as the divalent oxide. A process as claimed in any one of the preceding claims wherein the HF is contacted with the tetrahaloethylene at a mol ratio of 1:1 to 20:1 at a temperature of 300°C to 400°C, and a contact time of 5 to 100 seconds. A process as claimed in any one of the preceding claims wherein conversion of the tetrahaloethylene to fluorinated products is between 30% and 95%. A process as claimed in any one of the preceding claims wherein the metal is selected from the group consisting of manganese, nickel and cobalt. A process as claimed in any one of the preceding claims wherein the temperature, the mol ratio to HF to the tetrahaloethylene, and the contact time are controlled to yield a product stream having a CF 3 CHCl 2 content greater than that of CF 3 CHClF, and the combined total of CF 3 CHCl 2 and CF 3 CHClF is greater than that of CF 3 CHF 2 in the product stream. A process as claimed in any one of the preceding claims wherein the amount of the CF 3 CHF 2 in the product stream is less than ten percent. A process as claimed in any one of the preceding claims further comprising the step of recycling at least a portion of CF 3 CHCl 2 produced to the contacting step for conversion to additional CF 3 CHCIF. Claims for the following Contracting States : AT, BE, LU, GR A process for the preparation of 1,1,1-trifluorodichloroethane and 1,1,1,2-tetrafluorochloroethane by fluorination of a tetrahaloethylene, C 2 Cl 4-x F x , wherein x = 0 to 3, comprising contacting in the gaseous phase at 300°C to 450°C said tetrahaloethylene and HF with a catalyst comprising at least one metal in an oxidation state greater than zero, said metal selected from the group consisting of chromium, manganese, nickel and cobalt on a support comprising aluminium, oxygen and fluorine in such proportions that the support contains AlF 3 in an amount of at least 90% by weight of the catalyst composition exclusive of the metal, said AIF 3 content being obtained by pre-treatment of alumina impregnated with at least one compound of the metal with HF. A process as claimed in claim 1 wherein the tetrahaloethylene is tetrachloroethylene. A process as claimed in claim 1 or claim 2 wherein the catalyst contains 0.02 to 20 weight percent of metal expressed as the divalent oxide. A process as claimed in claim 3 wherein the catalyst contains 0.1 to 5 weight percent of metal expressed as the divalent oxide. A process as claimed in any one of the preceding claims wherein the HF is contacted with the tetrahaloethylene at a mol ratio of 1:1 to 20:1 at a temperature of 300°C to 400°C, and a contact time of 5 to 100 seconds. A process as claimed in any one of the preceding claims wherein conversion of the tetrahaloethylene to fluorinated products is between 30% and 95%. A process as claimed in any one of the preceding claims wherein the metal is selected from the group consisting of manganese, nickel and cobalt. A process as claimed in any one of the preceding claims wherein the temperature, the mol ratio to HF to the tetrahaloethylene, and the contact time are controlled to yield a product stream having a CF 3 CHCl 2 content greater than that of CF 3 CHClF, and the combined total of CF 3 CHCl 2 and CF 3 CHClF is greater than that of CF 3 CHF 2 in the product stream. A process as claimed in any one of the preceding claims wherein the amount of the CF 3 CHF 2 in the product stream is less than ten percent. A process as claimed in any one of the preceding claims further comprising the step of recycling at least a portion of CF 3 CHCl 2 produced to the contacting step for conversion to additional CF 3 CHClF.

Inventors: MANZER LEO ERNEST, RAO VELLIYUR, MANZER, LEO ERNEST, RAO, VELLIYUR, RAO, VELLIYUR NOTT MALLIKARJUNA
Applicants: DU PONT, E.I. DU PONT DE NEMOURS AND COMPANY
Application year: 1988
Main classification: C07C19
IPC codes: C07C19, C07C17, C07B61, B01J27, C07C67