HAIR TONIC

Abstract: Hair tonic showing excellent effect of preventing hair from falling off and a hair tonic effect, which is prepared by adding either (1) an amine oxide or (2) an amine oxide and an anionic surfactant. ABSTRACT A hair revitalizing tonic having an excellent hair loss prevention and hair revitalizing effect com­ prising (1) an amine oxide or (2) an amine oxide and an anionic surfactant formualted therein.

Description: This invention relates to the use of a hair tonic composition for revitalizing hair and for preventing dandruff. In the prior art, the causes of hair loss from the head are considered to be (1) an activation of male hormones at organs such as hair roots, and of the sebum gland, (2) and insufficient circulation of blood to hair follicles (3) an abnormal and excessive secretion of sebum, and the formation of peroxides, among others. Accordingly, compounds having the action of removing or alleviating the above-mentioned causes are usually formulated in the hair revitalizing tonics of the prior art. For example, vitamins such as vitamin E, vasodilators such as Swertia japonica extract, antiinflammatory agents such as hinokitiol, female hormone agents such as estradiol, and skin fuction promotors such as cepharanthine are formulated for a prophylaxis and therapy of alopecia. Nevertheless, the mechanism of hair loss and hair generation is complex, and a satisfctory hair loss prevention and hair revitalizing effect can be obtained only by inhibiting the activation of male hormones or increasing the circulation of blood to hair follicles, according to the hair revitalizing tonics of the prior art. There are known already various hair conditioner products comprising certain amine oxides comprising certain amine oxides, sometimes together with cationic surfactants. To produce for instance acidic hair shampoos (see f. i., Seifen- Öle- Fette- Wachse, vol. 105, no. 12, pgs. 345 to 346; USP 4659565; USP 4007261; GB-PS 1167369; EP-A-0168719). Accordingly, an object of the present invention is to solve the above problems of the prior art and provide a cosmetic hair tonic composition having an excellent hair revitalization effect and a dandruff preventing property. In accordance with the present invention for the aforementioned purpose a cosmetic hair tonic composition shall be used comprising 0.0001 to 20% by weight of an amine oxide formulated therein and an anionic surfactant formulated therein, the formulation ratio of the amine oxide to the anionic surfactant being 20/1 to 1/2 and wherein said amine oxide is at least one member selected from the group consisting of the amine oxides represented by the formulas (A), (B), (C) and (D), respectively: wherein R represents a straight or branched, saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms, R¹ and R² each independently represent a straight or branched, saturated or unsaturated hydrocarbon group having 6 to 18 carbon atoms, and n is an integer of 1 to 5, for revitalizing hair and for preventing dandruff. The anionic surfactant to be used in the hair revitalizing tonic according to the second embodiment of the present invention may include, for example, those shown below. Namely, there may be included base materials for soaps; fatty acid soaps such as sodium laurate and sodium palmitate; higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfate salts such as triethanolamine polyoxyethylene (hereinafter abbreviated as POE) lauryl sulfate and POE sodium lauryl sulfate; higher fatty acid amide sulfonates such as N-myristoyl-N-methyltaurin sodium, coconut oil fatty acid methyltaurid sodium, and laurylmethyltaurid sodium; phosphate esters such as sodium POE oleylether phosphate and POE stearyl ether phosphate; sulfosuccinates such as sodium di-2-ethylhexylsulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene-sulfonates such as sodium linear dodeceylbenzene sulfonate and triethanolamine linear dodecylbenzenesulfonate; N-acylglutamates such as monosodium N-lauroylglutamate, disodium N-stearoylglutamate, and monosodium N-myristoryl-L-glutamate; higher fatty acid ester sulfonates such as sodium hardened coconut oil fatty acid glycerine ester sulfate; sulfate oils such as Turkey red oil; POE alkyl ether carboxylic acids; POE alkylallyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfate salts; sodium lauroyl monoethanolamide succinate; ditriethanolamine N-palmitoylasparate; casein sodium; and the like, and these anionic surfactants can be used alone or as any desired mixture of two or more thereof. The formulation ratio of the amine oxide to the anionic surfactant is 20:1 to 1:5, preferably 8:1 to 1:2, in terms of percent by weight. If the formulation ratio of the amine oxide to the anionic surfactant is outside the range specified above, a satisfactory dandruff and itchy scalp prevention can not be obtained. Preferably, the amine oxide content is 0.0001 to 20% by weight. According to the present invention, an amine oxide or an amine oxide and an anionic surfactant can be formulated in a general system to prepare a desired hair revitalizing tonic. As such a system, for example, there may be included water, an alcohol (preferably ethanol, hereinafter the same), a water-alcohol mixture system (e.g., 20 to 99% by weight of an alcohol, the balance being water), an oil component, a water-oil component mixture system (0.2 to 80% by weight of oil component, the balance being water), an alcohol-oil component mixture system (0.2 to 80% of an oil component, the balance being alcohol), an water-alcohol-oil mixture system (20 to 99% by weight of alcohol, 0.01 to 10% by weight of a surfactant, the balance being water), a water-oil component-surfactant mixture system (0.2 to 80% by weight of an oil component, 0.01 to 10% by weight of a surfactant, the balance being water), and a water-alcohol-oil component-surfactant mixture system (20 to 99% by weight of an alcohol, 0.2 to 80% by weight of an oil component, 0.01 to 10% by weight of surfactant, the balance being water). As the above oil component and the surfactant, any of those generally used in hair revitalizing tonics or cosmetics of the prior art can be used. In the hair revitalizing tonic according to the present invention, in addition to the above essential components, general purpose components ordinarily used in hair revitalizing tonics can be formulated, within a range which does not impair the effect of the present invention, including vitamins such as vitamin B₆ , vitamin E and derivatives thereof , and biotin; hair generating agents or hair generating aids such as panthothenic acid and derivatives thereof, glycylrrhetic acid and derivatives thereof, nicotinic acid esters such as benzyl nicotinate, cyclosporins, capronium chloride, cepharanthine, oxendolone diazoxide, minoxidil, and ethynylestradiol; antibacterial agents such as kinokitiol, hexachlorophen, phenol, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichloro carbanilide, and bithionol; refrigerants such as menthol; drugs such as salicylic acid, zinc and derivatives, thereof, and lactic acid and alkyl esters thereof; organic acids such as citric acid; amino acids such as arginine; oil components such as olive oil, squalane, fluid paraffin, isopropyl myristate, higher fatty acids, and higher alcohols; polyhydric alcohols such as glycerine and propylene glycol; nonionic surfactants; cationic surfactants; perfumes; antioxidants; UV-ray absorvers; dyes; alcohols such as ethanol, benzyl alcohol, and isopropyl alcohol; water; humectants; and thickeners and the like. The hair tonic composition for use according to the present invention can be in any preparation form, provided that it can be applied to the outer skin, such as a liquid, an emulsion, an ointment, a cream, a gel, or a spray, and can be used in such forms as a tonic, a conditioner, or a scalp treatment. EFFECT OF THE INVENTION The hair tonic composition containing an amine oxide according to the present invention has an excellent dandruff prevention and hair revitalizing effect. Also, the hair tonic composition containing an amine oxide and an anionic surfactant has an excellent dandruff prevention, and hair revitalizing effect. EXAMPLES The present invention is described in more detail below by referring to Examples. In the following Examples, the formulation amounts are by % by weight, and the effect testing methods and evaluation methods used in the Examples are as described below. Hair Loss Prevention Effect Test This effect was judged by the determining the change in the number of hairs lost during hair washing, before and after using the sample. Eight persons were tested as a group for each of Examples 1 to 4 and for Comparative example 1, and 4 persons were tested as a group for each of Examples 5 to 10. The test period was 6 months, in which the sample was not used for the first 2 months, and was used during the last 4 months. During the period in which the sample was used, the sample was applied to the scalp twice a day, in an amount of 2 to 4 ml for each application. During the test period, the hair loss was determined by washing the hair every other day, and counting the total number of hairs lost each week. The number of hairs lost during each period is given by summarizing the data of the number of hairs lost during the 2 months for which the sample was not applied, multiplied by 8 to obtain a total, and the data of the number of hairs lost during the last 2 months of the 4 months during which the sample was applied, multiplied by 8 to obtain a total, in terms of the hair loss average value ± a standard deviation. The judgement of the effect was represented as follows, based on the difference in average values obtained in the respective periods. ++: remarkable effect observed with number of hair lost being reduced by 70 or more; +: considerable effect observed with number of hairs lost being reduced by 40 or more; ±: slight effect observed with number of hairs lost being reduced by 10 more; -: no effect observed with number of hairs lost being reduced by less than 10. Hair Revitalizing Effect Test To determine the hair revitalizing effect of the claimed hair tonic composition the trichogram test was carried out. Five persons were tested as a group for each of Examples 1 to 4 and for Comparative example 1, and four persons were tested as a group for each of Examples 5 to 10. The sample was applied for 3 months, during which period the sample was applied to the scalp twice a day, in an amount of 2 to 4 ml for each application. Immediately before application and immediately after application for 3 months, 50 hairs were removed from the pariretal region of the scalp, the hair roots of the removed hair were observed under a microscope, and the root resting period ratio (%) was calculated from the form of the hair roots. The hair revitalizing effect of each sample was based on a comparison of the increase or decrease in the resting period ratio before and after application of the sample. Dandruff Prevention Effect Test Four persons were tested as a group for each of the Examples and Comparative examples. The sample was applied for 3 months, during which period the hair was washed once per day with the same shampoo, not having a drug added thereto, and the test sample was applied to the scalp twice per day, in an amount of 2 to 4 ml for each application. On completion of the test period, the dandruff on the head was collected by an aspirating device from the persons tested, and the amount of protein in the dandruff was measured. Also, on completion of the test period, itching of the scalps of the persons tested was examined, and the extent of the itching was represented according to the following scores. Strong itch 3 Some itch 2 Slight itch 1 No itch 0 Examples 1 - 10 and Comparative Example 1 The formulations of Examples 1 - 10 and Comparative Example 1 are shown in Tables 1 and 2, the results of the hair loss prevention effect test of Examples 1 - 10 and Comparative Example 1 are shown in Tables 3 to 5, the results of the hair revitalizing effect test of Examples 1 - 10 and Comparative Example 1 are shown in Tables 6 and 7, and the results of the dandruff and itchy scalp prevention effect test of Examples, 1, 8, 9, 10 and Comparative Example 1 are shown in Table 8. Component Example Comparative Example 1 1 2 3 4 Dimethyllaurylamine oxide 0.2 - - - - Methyldioctylamine oxide - 0.008 - - - Dihydroxyethylstearylamine oxide - - 0.05 - - Lauryl PEO (3 mole addition) dimethylamine oxide - - - 1.0 - 95% Ethanol 75.0 75.0 75.0 75.0 75.0 Purified water balance balance balance balance balance Component Example 5 6 7 8 9 10 Dimethyllaurylamine oxide - - - 0.2 - 0.2 Dimethyloleylamine oxide 1.0 - - - 0.2 - Dimethylisostearylamine oxide - 0.3 - - - - Decylmethyloctylamine oxide - - 0.5 - - - Sodium lauryl sulfate - - - 0.06 - - Coconut oil fatty acid methyltaurid sodium - - - - 0.1 - Monosodium N-lauroylglutamate - - - - - 0.14 95% Ethanol 75.0 75.0 75.0 75.0 75.0 75.0 Purified water balance balance balance balance balance balance Group No. of person tested Number of hairs lost Judgement No application period Application period Example 1 1 289 ± 45 233 ± 55 + 2 500 ± 54 378 ± 70 + + 3 220 ± 41 217 ± 22 - 4 473 ± 54 391 ± 62 + + 5 351 ± 21 289 ± 33 + 6 255 ± 52 224 ± 39 ± 7 117 ± 36 113 ± 32 - 8 357 ± 53 302 ± 49 + Example 2 1 355 ± 38 246 ± 50 + + 2 433 ± 40 382 ± 35 + 3 458 ± 56 402 ± 46 + 4 313 ± 34 332 ± 45 - 5 375 ± 65 347 ± 62 ± 6 122 ± 15 126 ± 14 - 7 497 ± 75 476 ± 82 ± 8 231 ± 42 188 ± 33 + Example 3 1 258 ± 41 252 ± 38 - 2 433 ± 41 350 ± 62 + + 3 501 ± 53 455 ± 47 + 4 161 ± 57 120 ± 42 + 5 145 ± 22 138 ± 26 - 6 476 ± 76 365 ± 52 + + 7 512 ± 43 363 ± 77 + + 8 223 ± 22 195 ± 24 ± Group No. of person tested Number of hairs lost Judgement No application period Application period Example 4 1 126 ± 12 128 ± 15 - 2 468 ± 42 342 ± 54 + + 3 313 ± 41 302 ± 48 ± 4 500 ± 56 407 ± 62 + + 5 309 ± 51 268 ± 45 + 6 254 ± 42 241 ± 38 ± 7 497 ± 32 415 ± 39 + + 8 186 ± 21 163 ± 26 ± Comparative Example 1 1 421 ± 69 433 ± 64 - 2 423 ± 36 417 ± 42 - 3 346 ± 45 334 ± 50 ± 4 113 ± 21 121 ± 18 - 5 277 ± 69 260 ± 53 ± 6 189 ± 21 198 ± 23 - 7 290 ± 36 291 ± 43 - 8 567 ± 77 531 ± 83 + Group No. of person tested Number of hairs lost Judgement No application period Application period Example 5 1 482 ± 55 378 ± 70 + + 2 501 ± 54 366 ± 45 + + 3 186 ± 52 143 ± 22 + 4 357 ± 53 229 ± 36 + + Example 6 1 443 ± 41 323 ± 40 + + 2 313 ± 34 299 ± 23 ± 3 122 ± 15 126 ± 14 - 4 259 ± 52 188 ± 33 + + Example 7 1 443 ± 41 360 ± 62 + + 2 261 ± 57 220 ± 42 + 3 478 ± 76 367 ± 62 + + 4 223 ± 18 196 ± 20 ± Example 8 1 123 ± 11 122 ± 13 - 2 463 ± 54 371 ± 62 + + 3 155 ± 22 124 ± 29 ± 4 357 ± 53 251 ± 26 + + Example 9 1 333 ± 31 282 ± 25 + 2 313 ± 34 262 ± 29 + 3 122 ± 15 111 ± 14 ± 4 231 ± 42 148 ± 23 + + Example 10 1 322 ± 31 241 ± 32 + + 2 161 ± 57 155 ± 42 - 3 555 ± 45 412 ± 52 + + 4 213 ± 22 195 ± 23 ± Group No. of person tested Hair root resting ratio (%) Judgement Immediately before application After application Example 1 1 24.2 21.0 ± 2 42.0 29.6 + 3 12.0 12.7 - 4 35.7 14.1 + 5 33.4 25.2 + Example 2 1 36.1 36.9 - 2 41.8 27.2 + 3 33.9 29.8 ± 4 21.1 18.2 ± 5 25.3 14.0 + Example 3 1 17.1 15.3 ± 2 40.1 31.0 + 3 19.8 16.9 ± 4 36.9 25.3 + 5 28.6 21.2 + Example 4 1 22.9 20.8 ± 2 38.8 31.1 + 3 43.8 27.2 + 4 25.3 20.1 + 5 14.2 15.0 - Comparative Example 1 1 43.2 41.8 - 2 14.0 15.7 - 3 21.2 21.1 - 4 32.9 27.3 ± 5 38.0 40.6 - (+ remarkable effect, ± weak effect, - no effect) Group No. of person tested Hair root resting ratio (%) Judgement Immediately before application After application Example 5 1 25.1 19.2 + 2 16.2 13.6 ± 3 12.0 12.5 - 4 28.6 11.1 + Example 6 1 32.1 29.1 ± 2 29.3 20.1 + 3 18.3 15.5 ± 4 20.9 11.2 + Example 7 1 25.3 14.6 + 2 40.9 30.0 + 3 18.8 17.0 ± 4 32.6 24.6 + Example 8 1 22.0 19.6 ± 2 44.0 30.1 + 3 28.3 20.7 + 4 25.3 19.9 + Example 9 1 17.0 15.1 ± 2 40.1 32.0 + 3 24.3 18.9 + 4 35.9 29.9 + Example 10 1 22.2 19.4 ± 2 37.8 30.1 + 3 44.8 26.2 + 4 15.2 14.9 - (+ remarkable effect, ± weak effect, - no effect) Group Average amount of dandruff (mg) Itch (average score) Example 1 14.62 1.5 Example 8 6.93 0.5 Example 9 5.31 0.25 Example 10 6.65 0.25 Comparative Example 1 19.11 2.0 As apparent from the results shown in Tables 3 to 7, (1) the hair revitalizing tonic having an amine oxide formulated therein and (2) the hair revitalizing tonic having an amine oxide and an anionic surfactant formulated therein were found to have an excellent hair loss prevention effect and hair revitalizing effect. Also, as apparent from the result shown in Table 8, the hair revitalizing tonic having an amine oxide and an anionic suractrant formulated therein was found to have an excellent dandruff and itchy scalp prevention effect. Example 11 A lotion comprising the following composition was prepared. 95% Ethanol 50.0 Dimethyllaurylamine oxide 0.2 Sodium lauryl sulfate 0.06 Hardened castor oil ethylene oxide (40 mole) adduct 0.5 Purified water Balance Perfume and dye q.s. (Preparation methods) In 95% ethanol were dissolved hardened caster oil ethylene oxide (40 mol) adduct, and a perfume, and then purified water was added followed by an addition of dimethyllaurylamine oxide, sodium lauryl sulfate, and a dye, and the mixture was dissolved while stirring to obtain a transparent liquid lotion. Example 12 A lotion comprising the following composition was prepared. 95% Ethanol 90.0 Lauroyl POE (3 mole addition) dimethylamine oxide 3.0 Sodium lauryl sulfate 1.0 Hardened castor oil ethylene oxide (40 mole) adduct 0.5 Purified water Balance Perfume and dye q.s. (Preparation methods) In 95% ethanol were dissolved hardened caster oil ethylene oxide (40 mole) adduct, and a perfume, and then purified water was added followed by an addition of lauryl POE (3 mole addition) dimethylamine oxide, sodium lauryl sulfate, and a dye, and the mixture was dissolved while stirring to obtain a transparent liquid lotion. Example 13 (A phase) Fluid paraffin 5.0 Cetostearyl alcohol 5.5 Glycerine monostearate 3.0 Polyoxyethylene (20 mole addition) 2-octyldodecyl ether 3.0 Vitamin E acetate 0.05 Propyl paraben 0.3 Perfume 0.05 (B phase) Glycerine 7.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Purified water Balance Dimethylcetylamine oxide 12.0 (Preparation method) The A phase and the B phase were respectively dissolved by heating, mixed, and then emulsified by a homomixer to obtain a hair revitalizing tonic in the form of an ointment. Example 14 (A phase) Cetanol 2.0 Petrolatum 5.0 Squalane 10.0 Polyoxyethylene (10 mole addition) monostearate 2.0 Sorbitane monooleate 1.0 Dimethylstearylamine oxide 1.0 Perfume 0.1 (B phase) Glycerine 10.0 20% Gluconic acid chlorohexidine solution 0.1 Purified water Balance (Preparation method) The A phase and the B phase were respectively dissolved by heating, were mixed, and were emulsified by a homomixer to obtain a hair revitalizing tonic in the form of an emulsion. Examples 11 to 14 were found to have an excellent hair loss prevention effect and hair revitalizing tonic effect. Also, Examples 11 and 12 further had an excellent dandruff and itchy scalp prevention effect.

Claims: The use of a cosmetic hair tonic composition comprising 0.0001 to 20% by weight of an amine oxide formulated therein and an anionic surfactant formulated therein, the formulation ratio of the amine oxide to the anionic surfactant being 20/1 to 1/2 and wherein said amine oxide is at least one member selected from the group consisting of the amine oxides represented by the formulas (A), (B), (C) and (D), respectively: wherein R represents a straight or branched, saturated or unsaturated hydrocarbon group having 8 to 24 carbon atoms, R¹ and R² each independently represent a straight or branched, saturated or unsaturated hydrocarbon group having 6 to 18 carbon atoms, and n is an integer of 1 to 5, for revitalizing hair and for preventing dandruff. The use of the hair tonic composition as claimed in claim 1 wherein the amine oxide content in 0.05 to 5% by weight. The use of the hair tonic composition as claimed in claim 1 or 2, wherein the ratio of the amine oxide to the anionic surfactant is 8/1 to 1/2.

Inventors: ISHINO AKIHIRO SHISEIDO LABORA, MIYAZAWA KIYOSHI SHISEIDO LABO, NAKANISHI JOTARO SHISEIDO LABO, UCHIKAWA KEIICHI SHISEIDO LABO, ISHINO, AKIHIRO SHISEIDO LABORATORIES, MIYAZAWA, KIYOSHI SHISEIDO LABORATORIES, NAKANISHI, JOTARO SHISEIDO LABORATORIES, UCHIKAWA, KEIICHI SHISEIDO LABORATORIES
Applicants: SHISEIDO CO LTD, SHISEIDO COMPANY LIMITED
Application year: 1988
Main classification: A61K7
IPC codes: A61K8, A61Q5, A61Q7