PYRIDINE DERIVATIVES

Abstract: This invention relates to novel pyridine derivatives and 1,2,3,4-tetrahydropyridine derivatives shown by following general formula (I) or (II) and salts thereof which are useful as psychotropic medicaments: <IMAGE> (I) <IMAGE> (II) wherein A is S or O; R1 represents an unsubstituted or substituted alkoxy, amino, hydrazino, or 6- or 7-membered heterocyclic group having one or two nitrogen atoms with the proviso that R1 is not an alkoxy group in formula (I); R2 and R3 each represents a hydrogen atom or an unsubstituted or substituted alkyl, aryl, alkenyl, acyl, arylcarbonyl group; and m and n each represents an integer of from 0 to 4.

Description: FIELD OF THE INVENTION This invention relates to pyridine derivatives or 1,2,3,4-tetrahydropyridine derivatives represented by general formulae (I) and (II) or the salts thereof which act on the central nervous system and are useful as psychotropic drugs having antianxiety effects and learning improvement effects. BACKGROUND OF THE INVENTION It is known that β-carboline-3-carboxylic acid derivatives shown by the following general formula are useful as a psychotic medicament having a sedative activity (U.S. Patent 4,371,536). Also, it is known that 1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine derivatives shown by the following general formula are useful as a sedative and a hypotensive drug (U.S. Patent 3,651,068). Furthermore, methods for synthesizing 1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]-pyridine and derivatives thereof as well as the biochemical activities of these compounds are described in Arch. der Pham., 309, 279 (1976) and Journal of Pharmacology and Experimental Therapeutics , 235(3) , 696-708 (1985). In addition, reference is made to EP-A-0 030 254, GB-A-1 210 106, EP-A-0 094 271, EP-A-0 003 920 and JP-A-61.236779 describing other benzoheterocyclopyridine derivatives. There has been, however, still a need for other benzoheterocyclopyridine derivatives offering possibilities for an application in the medical and therapeutical field. However, the pyridine derivatives or 1,2,3,4-tetrahydropyridine derivatives of the present invention represented by general formula (I) and (II) have not yet been known and also the medical effects thereof are not known. SUMMARY OF THE INVENTION The present inventors have intensively investigated the pyridine derivatives and 1,2,3,4-tetrahydropyridine derivatives having general formulae (I) and (II), respectively. Accordingly, one object of this invention is to provide novel pyridine derivatives and 1,2,3,4-tetrahydropyridine derivatives useful as medicaments having an antianxiety activity and a learning improvement activity represented by the following general formulae (I) and (II) or salts thereof: wherein A is a sulfur atom or an oxygen atom; R 1 is a methoxy, an ethoxy, a propyloxy, a hexyloxy or a benzyloxy group; an amino group, a hydrogen atom bonded to the nitrogen atom of this group may be substituted, wherein the substituent is a C 1-6 -alkyl group, a hydrogen atom bonded to a carbon atom thereof may be substituted by an amino group, a carboxy group or an ester group; a hydrazino group; or a 6- or 7-membered heterocyclic group having at least one N-atom which may be substituted by a C 1-6 -alkyl group, a phenyl group or a 5- to 7-membered heterocyclic group having an N-atom; with the proviso that in formula (I), R 1 is not an alkoxy group; R 2 and R 3 are a halogen atom, an alkyl group, an aryl group, an alkenyl group, an acyl group, or an arylcarbonyl group which have 1 to 20 carbon atoms and may be substituted by a halogen atom, an amino group, a nitro group, an alkoxy group having 1 to 6 carbon atoms or a phenyl group; and m and n are an integer of from 0 to 4, with the proviso that when m is 2 or more, said R 2 (s) may be the same or different and that when n is 2 or more, said R 3 (s) may be the same or different. DETAILED DESCRIPTION OF THE INVENTION This invention relates to pyridine derivatives and 1,2,3,4-tetrahydropyridine derivatives shown by general formulae (I) and (II) or salts thereof: In formulae (I) and (II), A is a sulfur atom or an oxygen atom. R 1 is a methoxy, an ethoxy, a propyloxy, a hexyloxy or a benzyloxy group; an amino group, a hydrogen atom bonded to the nitrogen atom of this group may be substituted, wherein the substituent is a C 1-6 -alkyl group, a hydrogen atom bonded to a carbon atom thereof may be substituted by an amino group, a carboxy group or an ester group; a hydrazino group; or a 6- or 7-membered heterocyclic group having at least one N-atom which may be substituted by a C 1-6 -alkyl group, a phenyl group or a 5- to 7-membered heterocyclic group having an N-atom; with the proviso that in formula (I), R 1 is not an alkoxy group; R 2 and R 3 are a halogen atom, an alkyl group, an aryl group, an alkenyl group, an acyl group, or an arylcarbonyl group which have 1 to 20 carbon atoms and may be substituted by a halogen atom, an amino group, a nitro group, an alkoxy group having 1 to 6 carbon atoms or a phenyl group; and m and n are an integer of from 0 to 4, with the proviso that when m is 2 or more, said R 2 (s) may be the same or different and that when n is 2 or more, said R 3 (s) may be the same or different. Examples of R 1 are a 2-aminoethylamino group, a 3-aminopropylamino group, a methylamino group, an ethylamino group, a propylamino group, a hexylamino group, a 4-aminobutyric acid group, a 4-aminobutyric acid ethyl ester group, a piperazino group, a 2,6-dimethylpiperidino group, a piperazinyl group, a 3-methylpiperazinyl group, a 4-methylpiperazinyl group, a hexahydro-1H-1,4-diazepinyl group, a hexahydro-1H-4-methyldiazepinyl group and a morpholino group. R 2 and R 3 are a halogen atom, an alkyl group, an aryl group, an alkenyl group, an acyl group or an arylcarbonyl group, each of said groups being optionally substituted. The total carbon atom number of these groups is from 1 to 20 and a hydrogen atom bonded to a carbon atom in any of these groups may be substituted by another group, if desired. Suitably substituents Examples of R 2 and R 3 are a chlorine atom, a methyl group, a phenyl group, an allyl group, a 2-chlorobenzoyl group, a 4-methoxybenzyl group, a benzyl group, a 4-nitrobenzyl group, an acetyl group, etc. Examples of the pyridine derivatives and 1,2,3,4-tetrahydropyridine derivatives of this invention are given below: (1) 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]-pyridine-3-carboxylic acid ethyl ester (2) 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]-pyridine-3-carboxylic acid methyl ester (3) 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]-pyridine-3-carboxylic acid propyl ester (4) 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]-pyridine-3-carboxylic acid hexyl ester (5) 1,2,3,4-Tetrahydro-benzo[b]furano[2,3-c]-pyridine-3-carboxylic acid ethyl ester (6) 1,2,3,4-Tetrahydro-benzo[b]furano[2,3-c]-pyridine-3-carboxylic acid propyl ester (7) 2-(2-Chlorobenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (8) 2-Acetyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (9) 2-(4-Methoxybenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (10) 2-(4-Aminobutyroyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (11) 2-(4-Methoxybenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (12) 2-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (13) 2-Allyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (14) 2-Benzyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (15) 2-(4-Nitrobenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ether ester (16) 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid benzyl ester (17) 1-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (18) 4-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (19) 6-Chloro-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (20) Hexahydro-1-(1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine (21) N-(2-Aminoethyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamide (22) Hexahydro-1-(4-methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-azepine (23) Hexahydro-1-(1-phenyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine (24) Hexahydro-1-(6-chloro-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine (25) N-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamide (26) N-Ethyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamide (27) 4-(1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine (28) N-(4-Morpholino)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamide (29) 1-(1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-4-pyrimidinyl-piperazine (30) 4-(1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid ethyl ester (31) 4-(1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid (32) 4-(2-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine (33) 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-piperidine (34) 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-2,6-dimethylpiperidine (35) 4-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine (36) Hexahydro-1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine (37) 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-piperazine (38) 1-[Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-3-methylpiperazine (39) 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-4-methylpiperazine (40) Hexahydro-1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-4-methyldiazepine (41) N-(2-Aminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide (42) N-(3-Aminopropyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide (43) N-(2-Aminoethyl)-4-methylbenzo[b]thieno[2,3-c]pyridine-3-carboamide (44) N-(2-Aminoethyl)-6-chlorobenzo[b]thieno[2,3-c]pyridine-3-carboamide (45) N-(2-Aminoethyl)-benzo[b]furano[2,3-c]pyridine-3-carboamide (46) N-(2-Aminoethyl)-1-phenyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide (47) Benzo[b]thieno[2,3-c]pyridine-3-carboamide (48) Benzo[b]thieno[2,3-c]pyridine-3-carbohydrazide (49) N-(2-Dimethylaminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide (50) N-Methyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide (51) N-Ethyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide (52) N-Propyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide (53) N-Hexyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide (54) 4-(Benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid ethyl ester (55) 4-(Benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid. The pyridine derivatives of this invention represented by general formula (I) described above can be obtained by the following synthesis methods. 1) Method 1: In the above formulae (III) to (VIII), A, R 1 , R 2 , R 3 , m and n have the same meaning as described above for formulae (I) and (II); R 4 and R' 4 each represents a hydrogen atom or a group represented by said R 2 ; and X 1 is a group which becomes an acid by combining with hydrogen atom (such as a halogen atom, a methanesulfonyl group, a 4,6-dimethylpyridinylmercapto group, etc.), or a group which is excellent as a releasable group. A method of obtaining compound (IV) from compound (III) is described by H.R. Snyder and Donal S. Matterson in Journal of American Chemical Society, 79 , 2217 (1957). A suitable solvent used in the method of synthesizing compound (IV) from compound (III) is a mixed solvent of a polar solvent such as acetic acid, dimethylformamide, etc., and a non-polar solvent such as benzene, toluene, etc. In this case, it is preferred that a benzene solution of an alkyldeneisopropylamine is added dropwise to a solution of compound (III) dissolved in acetic acid. The alkyldeneisopropylamine is used in an amount of from 1 to 3 equivalents, and preferably from 1.1 to 1.5 equivalents. Also, in place of the alkyldeneisopropylamine, an alkyldene tert-butylamine or the like may be used. As a reaction catalyst, hydrochloric acid, sulfuric acid, etc., may be added. The reaction is performed at temperature of from -20°C to 50°C, and preferably from 0°C to 10°C. The reaction is generally completed after 10 to 70 hours. A method of obtaining compound (V) and compound (VI) from compound (IV) is described by D.A. Little and D.I. Wesblat in Journal of American Chemical Society , 69 , 2118 (1947). A suitable solvent used in the method of synthesizing compound (V) from compound (IV) is xylene, toluene, etc., and is preferably xylene. The reaction temperature is from 50°C to 150°C, and preferably from 90°C and 100°C. The reaction is generally completed after 1 to 12 hours. An alkyl nitroacetate is used in an amount of from 1 to 3 equivalents. A suitable solvent used in the method of synthesizing compound (VI) from compound (V) is preferably a mixed solvent of a polar solvent such as methanol, ethanol, etc., and water. The reaction temperature is from 10°C to 120°C, and preferably from 60°C to 80°C. The reaction is generally completed after 10 to 120 minutes. Iron powder is used in an amount of from 1 to 10 equivalents and hydrogen chloride is used in an amount of from 1 to 20 equivalents. Also, in place of iron powder, a metal such as zinc or the like may be used or the reduction by hydrogen may be performed in the presence of a catalyst such as Raney nickel, palladium-active carbon, etc. A method of synthesizing compounds (VII) and (VIII) from compound (VI) is described by Gerhard Wolf and Felix Zymalkowsiki in Arch. Pharm. , 309, 279 (1976). A suitable solvent used in the method of synthesizing compound (VII) from compound (VI) is an organic solvent such as ethanol, benzene, etc. The reaction temperature is from 50°C to 150°C and the reaction is generally completed after 1 to 12 hours. A suitable solvent used in the method of synthesizing compound (VIII) from compound (VII) is methanol, ethanol, water, etc., and is preferably water. The reaction temperature is from 50°C to 120°C and the reaction is generally completed after 10 minutes to 2 hours. As the reaction catalyst, an acid such as hydrochloric acid, sulfuric acid, p-toluenesulfonic acid, etc., is used in an amount of from 10 to 100 equivalents. A suitable method for obtaining compound (I) from compound (VIII) (but not disclosing the present novel compounds) is described by Michael Cainet et al in Journal of Medical Chemistry , 25 , 1081 (1982). A suitable solvent used in the method of synthesizing compound (I) from compound (VIII) is an organic solvent such as benzene, toluene, xylene, dioxane, tetrahydrofuran, etc. Elementary sulfur is used in an amount of from 1 to 30 equivalents, preferably from 15 to 25 equivalents. The reaction temperature is from 50°C to 150°C, and preferably from 100°C to 120°C. The reaction is generally completed after 1 to 7 days. Also, in other similar synthesis methods, dichlorodicyanobenzoquinone, chloroanisole, tetraacetic acid salts, palladium-black, or palladium-active carbon may be used. 2) Method 2: The following method may be used by using the material of aforesaid formula (IV) as a starting material. In the above formulae (IX) to (XVI), A, R 1 , R 2 , R 3 , R 4 , and R' 4 have the same meaning as described above in formulae (I) to (VIII). Further, R 5 is an alkyl group having from 1 to 6 carbon atoms, such as a methyl group, an ethyl group, etc. R 11 and R 12 each is a hydrogen atom, an unsubstituted or substituted alkyl group, an unsubstituted or substituted amino group, or an unsubstituted or substituted 5- to 7-membered heterocyclic group containing a nitrogen atom, or R 11 and R 12 may together form a 6- to 7-membered heterocyclic group with an adjacent nitrogen atom. Boc is tertiary butoxycarbonyl group and X 1 , X 2 , and X 3 each represents a group which becomes an acid by combining with a hydrogen atom (such as a halogen atom, a methanesulfone group, a 4,6-dimethylpyrimidinylmercapto group, etc.), or a group which is excellent as a releasable group. A method of obtaining compounds (IX) and (X) from compound (IV) is described by D.A. Little and D.I. Wesblat in Journal of American Chemical Society , 69 , 2118 (1947). A suitable solvent used in the method of synthesizing compound (IX) from compound (IV) is xylene, toluene, etc., and preferably xylene. The reaction temperature is from 50°C to 150°C and preferably from 90°C to 100°C. The reaction is generally completed after 1 to 12 hours. An alkyl nitroacetate is used in an amount of from 1 to 3 equivalents. A suitable solvent used in the method of synthesizing compound (X) from compound (IX) is preferably a mixed solvent of a polar solvent such as methanol, ethanol, etc., and water. The reaction temperature is from 10°C to 120°C, and preferably from 60°C to 80°C. The reaction is generally completed after 10 to 120 minutes. Iron powder is used in an amount of from 1 to 10 equivalents and hydrogen chloride is used in an amount of from 1 to 20 equivalents. Also, in place of iron powder, a metal such as zinc, etc., may be used and the reduction by hydrogen may be performed in the presence of a catalyst such as Raney nickel, palladium-active carbon, etc. A method of synthesizing compound (XI) and (XII) from compound (X) is described by Gerhard Wolf and Felix Zymalkowski in Arch. Pham. , 309, 279 (1976). A suitable solvent used in the method of synthesizing compound (XI) from compound (X) is an organic solvent such as ethanol, benzene, etc. The reaction temperature is from 50°C to 150°C and the reaction is generally completed after 1 to 12 hours. A suitable solvent used in the method of synthesizing compound (XII) from compound (XI) is methanol, ethanol, water, etc., and is preferably water. The reaction temperature is from 50°C to 120°C. The reaction is generally completed after 10 minutes to 2 hours. Also, as a reaction catalyst, hydrochloric acid, sulfuric acid, p-toluenesulfonic acid, etc., is used in an amount of from 10 to 100 equivalents. A method of obtaining compound (XIII) from compound (XII) is described by T. Nakagawa, L. Kuroiwa, K. Narita, and Y. Isowa in Bulletin of the Chemical Society of Japan , 46 , 1269 (1973). A suitable solvent used in the method of synthesizing compound (XIII) from compound (XII) is an organic solvent such as chloroform, methylene chloride, tetrahydrofuran, dimethylformamide, etc. The reaction temperature is from 0°C to 100°C and the reaction is generally completed after 1 to 48 hours. For neutralizing HX 1 of compound (XII), a tertiary amine such as triethylamine, N-methylmorpholine, etc., is used. Also, as a method of introducing a tertiary butoxycarbonyl group (Boc group), a tertiary butoxycarbonylating agent such as Boc-azide, etc., may be used. Alternatively, in place of a Boc group, other amino protective groups such as benzyloxycarbonyl, etc., may be used. A method of obtaining compound (XIV) from compound (XIII) is described by E. Brand, B.F. Erlanger, H. Sacks, and J. Polathick in Journal of American Chemical Society , 73 , 3510 (1951). A suitable solvent used in the method of synthesizing compound (XIV) from compound (XIII) is an alcohol such as methanol, ethanol, etc., or water. The reaction temperature is from 0°C to 80°C and the reaction is generally completed after 1 to 48 hours. Sodium hydroxide is used in an amount of from 1 to 3 equivalents and potassium hydroxide may be used instead. As an acid for neutralizing the alkali, citric acid or acetic acid is used. A method of obtaining compound (XV) from compound (XIV) is described by G.W. Anderson, E. Zimmermann, and F. Callahan in Journal of American Chemical Society , 85 3039 (1963). A suitable solvent used in the method of synthesizing compound (XV) from compound (XIV) is an organic solvent such as chloroform, methylene chloride, dioxane, tetrahydrofuran, dimethylformamide, etc. The reaction temperature is from -20°C to 100°C. The reaction is usually completed after 10 minutes to 48 hours. As a method for the amido bond-forming reaction, an active ester method by N-hydroxysuccinimide is employed. N-hydroxysuccinimide is generally used in an amount of from 1 to 3 equivalents. Sodium hydroxide is used in an amount of from 1 to 3 equivalents. Also, other suitable methods include an acid chloride method, a dicyclohexylcarbodiimide method, a mixed acid anhydride method, etc. A method of obtaining compound (XVI) from compound (XV) is described by G.W. Anderson and A.C. Mcgregor in Journal of American Chemical Society , 79 , 6180 (1957). A suitable solvent used in the method of synthesizing compound (XVI) from compound (XV) is ethyl acetate or dioxane. The reaction temperature is from -20°C to 100°C. The reaction is generally completed after 10 minutes to 5 hours. Hydrochloric acid is used in an amount of from 1 to 20 equivalents. Also, in place of hydrochloric acid, trifluoroacetic acid, hydrogen bromide, hydrogen fluoride, methanesulfonic acid, etc., may be used. A method of obtaining compound (I) from compound (XVI) (but not disclosing the novel compounds of formula (I)) is referred to Michael Cain et al in Journal of Medical Chemistry , 25 , 1081 (1982). A suitable solvent used in the method of synthesizing compound (I) from compound (XVI) is an organic solvent such as benzene, toluene, xylene, dioxane, tetrahydrofuran, etc. Elementary sulfur is used in an amount of from 1 to 30 equivalents, and preferably from 15 to 25 equivalents. The reaction temperature is from 50°C to 150°C, and preferably from 100°C to 120°C. The reaction is generally completed within 1 day to 7 days. Also, in other suitable methods dichlorodicyanobenzoquinone, chloroanisole, lead tetraacetate, palladium-black, or palladium-active carbon may be used. As a method of obtaining compound (I), the synthesis may be performed by the following route from the compound of aforesaid formula (X): 3) Method 3: Also, in another suitable amidation method, the amide is directly formed from the ester. 4) Method 4: In this case, a catalyst such as phenyllithium, etc., may be used. The 1,2,3,4-tetrahydropyridine derivatives represented by formula (II) described above can be obtained by the following synthesis methods from the compounds represented by aforesaid formula (VIII). 5) Method 5: wherein A, R 1 , R 2 , R 3 , R 4 , R' 4 , X 1 , and X 2 have the same meaning as described in the above various formulae and R" 4 has the same meaning as R' 4 . A suitable method for obtaining compound (II) from compound (VIII) (but not disclosing the novel compounds of formula (II)), is described by B. Bortnick, et al in Journal of American Chemical Society , 78 , 4039 (1956). A suitable solvent used in the method of synthesizing compound (II) from compound (VIII) is an organic solvent such as chloroform, ethanol, etc., and is preferably chloroform. The reaction temperature is from 0°C to 100°C, and preferably from 30°C to 60°C. The reaction is generally completed after 1 to 12 hours. For neutralizing HX 1 of compound (XIII), a tertiary amine such as triethylamine, N-methylmorpholine, 1,8-diazabicyclo[5,4,0]-7-undecene, etc., is used. Also, the synthesis may be performed by the following method using the compound of aforesaid formula (XVI) as the starting material. 6) Method 6: A suitable solvent used in the method of synthesizing compound (II) from compound (XVI) is an organic solvent such as chloroform, dioxane, ethanol, etc., and is preferably chloroform. The reaction temperature is from 0°C to 150°C, and preferably from 30°C to 60°C. The reaction is generally completed after 1 to 24 hours. General formula R" 4 X 4 represents methyl bromide, chlorinated acetyl, etc., and is usually used in an amount of from 1 to 3 equivalents. For neutralizing HX 3 and by-produced HX 4 , a tertiary amine such as triethylamine, N-methylmorpholine, 1,8-diazabicyclo[5,4,0]-7-undecene, etc., is used. As a method of obtaining compound (II), the synthesis may be performed by the following route from the compound of aforesaid formula (X): 7) Method 7: 8) Method 8: Also, in a similar amidation method, the amide may be directly formed by the ester. In this case, a catalyst such as phenyllithium, etc., may be used: Also, the compounds represented by general formulae (I) and (II) described above can be converted into their phamaceutically acceptable acid- or base-addition salts. Suitable pharmaceutically acceptable acid-addition salts include, for example, the acid-addition salts with an inorganic acid such as a hydrochloric acid, sulfuric acid, phosphoric acid, etc., or an organic acid such as acetic acid, p-toluenesulfonic acid, maleic acid, etc. Also, suitable base-addition salts include the base-addition salts with an inorganic base such as sodium hydroxide, calcium hydroxide, etc., or an organic base such as ammonia, triethylamine, etc. The present invention is further explained in detail hereinafter by the following specific examples, but the invention is not limited to these examples. Example 1 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester was obtained by the following method. In 150 ml of glacial acetic acid was dissolved 33.6 g of benzo[b]thiophene, and 50 ml of a benzene solution of 19.6 g of methylideneisopropylamine was added dropwise to the solution under ice-cooling. After allowing the temperature to rise to room temperature and stirring the mixture for 2 days, the reaction mixture was poured in 500 ml of water and washed twice with 100 ml of ether. The aqueous layer thus formed was adjusted to pH 10.0 with an aqueous 5N sodium hydroxide solution and extracted 4 times with 100 ml ethyl acetate. The ethyl acetate layer was collected, washed with an aqueous saturated sodium chloride solution, dried by sodium sulfate, dried, then dried under reduced pressure, and the product was subjected to silica gel column chromatography to provide 30.8 g (yield of 60%) of (benzo[b]thiophen-3-ylmethyl)isopropylamine. IR (ν max , cm -1 ): 3300, 2960, 2870, 1550, 1440, 760, 740. NMR (δ, CDCl 3 ): 1.10 (d, J=6Hz, 6H), 2.50-2.90 (m, 1H), 3.80 (s, 2H), 7.20-7.50 (m, 3H), 7.60-7.90 (m, 2H). In 50 ml of dry xylene were dissolved 10.97 g of (benzo[b]thiophen-3-ylmethyl)isopropylamine and 13.3 g of ethyl nitroacetate and the temperature of the solution was raised to 100°C with stirring under nitrogen gas stream. After 5 hours. insoluble matter was filtered off, the solvent was distilled off under reduced pressure from the filtrate, and the residue was dissolved in 500 ml of ethyl acetate. The solution was washed thrice with 100 ml of an aqueous 5% citric acid solution, thrice with 100 ml of an aqueous 5% sodium hydrogencarbonate solution, and then twice with 100 ml of a saturated aqueous sodium chloride solution and after drying with sodium sulfate, ethyl acetate was distilled off under reduced pressure from the solution. After removing excess ethyl nitroacetate by means of a vacuum pump, the residue was subjected to silica gel column chromatography to provide 11.17 g (yield of 80%) of 3-(benzo[b]thiophen-3-yl)-2-nitropropionic acid ethyl ester. IR (ν max , cm -1 ): 2960, 2870, 1730, 1550, 1370, 1250, 760, 740. NMR (δ, CDCl 3 ): 1.10 (t, J=6Hz, 3H), 3.15 (dd, 2H), 3.50-3.80 (m, 1H), 4.00 (q, 2H), 7.10-7.50 (m, 3H), 7.50-7.90 (m, 2H). To a mixed solution of 7.5 ml of water, 7.5 ml of ethanol, and 10 ml of 12N hydrochloric acid were added 3.5 g of iron powder and 2.79 g of 3-(benzo[b]thiophen-3-yl)-2-nitropropionic acid ethyl ester and then the reaction was carried out for one hour at room temperature. After filtered away excess iron powder, 200 ml of water was added to the filtrate and after adjusting the pH thereof to from 9 to 10 with sodium hydrogencarbonate, the mixture was extracted thrice with 50 ml of chloroform. The chloroform layer was washed twice with 200 ml of water and then twice with 100 ml of a saturated aqueous sodium chloride solution and after drying with magnesium sulfate, chloroform was distilled off under reduced pressure. The residue was dissolved in ethyl acetate, 10 ml of a solution composed of IN hydrochloric acid and ethyl acetate, and crystals thus deposited were collected by filtration to provide 1.14 g (yield of 40%) of 2-amino-3-(benzo[b]thiophen-3-yl)propionic acid ethyl ester. IR (ν max , cm -1 ): 3420, 3050, 2970, 1740, 1570, 1480, 1240, 760, 740. NMR (δ, CDCl 3 ): (free compound): 1.10 (t, J= 6Hz, 3H), 1.50 (s, 2H), 3.15 (dd, 2H), 3.50-3.80 (m, 1H), 4.00 (q, 2H), 7.10-7.50 (m, 3H), 7.50-7.90 (m, 2H). In a mixed solution of 200 ml of ethanol and 200 ml of water were dissolved 23.24 g of 2-amino-3-(benzo[b]thiophen-3-yl)propionic acid ethyl ester·hydrochloride and 10.2 ml of formalin, and the solution was refluxed for 3 hours with stirring. The reaction mixture was concentrated to about one half its original volume and after adjusting the pH thereof to from 9 to 10 with sodium hydrogencarbonate, the mixture was extracted thrice with chloroform. The chloroform layer was washed twice with 100 ml of a saturated aqueous sodium chloride solution and after drying with magnesium sulfate, chloroform was distilled off under reduced pressure. The residue was recrystallized from a mixture of chloroform and ether to provide 14.84 g (yield of 69%) of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3,c]pyridine-3-carboxylic acid ethyl ester. IR (ν max , cm -1 ): 2970, 2900, 1720, 1430, 1195, 760, 740. NMR (δ, CDCl 3 ): 1.35 (t, J=5Hz, 3H), 2.25 (s, 2H), 3.10 (dd, 2H), 3.70-4.00 (m, 1H), 4.30 (q, 2H), 7.30-8.00 (m, 4H). Example 2 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-carboxylic acid methyl ester was synthesized by the following method. A mixture of 2.85 g of 2-amino-3-(benzo[b]thiophen-3-yl)-propionic acid ethyl ester-hydrochloride as prepared in Example 1 and 400 mg of sodium hydroxide was stirred in 20 ml of water under refluxing for 12 hours. The aqueous layer was adjusted to pH 4.0 with concentrated hydrochloric acid. After allowing the mixture to stand overnight in a refrigerator, 2-amino-3-(benzo[b]thiophen-3-yl)-propionic acid was collected by filtration and dried under reduced pressure. 2.01 g (yield of 91%). IR (ν max , cm -1 ): 1590, 1420, 1020. NMR (δ, D 2 O, (CH 3 Si)(CH 2 )-SO 3 Na): 3.00-4.00 (m, 3H), 7.20-8.00 (m, 5H). By referring to Examples 3.2 described in page 66 of Peptide Gosei (Synthesis) of Gosei Kagaku (Synthesis Chemistry) series by Nobuo Isumiya, Tetsuo Kato, Motonori Oono, and Toohiko Aoyagi, published by Maruzen K.K., the following reaction was carried out. After cooling 640 ml of desiccated methanol to 0°C, 20.8 ml of thionyl chloride was gradually added thereto and the mixture was stirred for 30 minutes at 0°C. Then, 16.0 g of 2-amino-3-(benzo[b]thiophen-3-yl)-propionic acid was added to the mixture at 0°C, the resultant mixture was stirred for 30 minutes and after further stirring for 2 days at room temperature, methanol was distilled off under reduced pressure. To the residue were added 300 ml of methylene chloride and 150 ml of an aqueous 5% sodium hydrogencarbonate solution followed by extracting. The methylene chloride layer was dried by magnesium sulfate and the solvent was distilled off under reduced pressure to provide 15.8 g (yield of 93%) of 2-amino-3-(benzo[b]-thiophen-3-yl)-propionic acid methyl ester. IR (ν max , cm -1 ): 2975, 1730, 1180. NMR (δ, CDCl 3 ): 3.0-3.37 (m, 3H), 4.07 (s, 3H), 7.17-8.00 (m, 5H). To 50 ml of ethyl acetate was added 15.8 g of 2-amino-3-(benzo[b]thiophen-3-yl)-propionic acid methyl ester and after further adding thereto 11.56 g of p-toluenesulfonic acid, the mixture was allowed to stand overnight at room temperature. Crystals thus deposited were collected by filtration to provide 24.90 g (yield of 91%) of 2-amino-3-(benzo[b]thiophen-3-yl)-propionic acid methyl ester·p-toluenesulfonate. IR (ν max , cm -1 ): 3050, 2940, 1738, 1590, 1500. To a mixture of 25 ml of water and 25 ml of methanol was added 4.074 g of 2-amino-3-(benzo[b]thiophen-3-yl)-propionic acid methyl ester and after further adding thereto 1.3 ml of a 35% formalin solution, the mixture was refluxed with stirring for 14 hours. The reaction mixture was concentrated to one half its original volume and then allowed to stand overnight at room temperature. Crystals thus deposited were collected by filtration and dried to provide 3.934 g (yield of 93%) of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid methyl ester·p-toluenesulfonate. Furthermore, 30 ml of chloroform and 30 ml of water were added to the product and after adjusting the pH of the aqueous layer to 9.5 with sodium hydrogencarbonate, the product therein was extracted. The chloroform layer was dried with sodium sulfate and the solvent was distilled off under reduced pressure to provide 2.32 g of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid methyl ester. IR (ν max , cm -1 ): 3300, 1730, 1460, 1435 NMR (δ, CDCl 3 ): 2.18 (bs, 1H), 3.02 (m, 2H), 3.85 (m, 4H), 4.23 (bs, 2H), 7.66 (m, 4H). Mass (m/z): 247 (M + ); 187, 160, 128, 115, 94 Example 3 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid propyl ester and 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid hexyl ester were synthesized using 2-amino-3-(benzo[b]thiophen-3-yl)-propionic acid by following the same procedure as Example 2 except that 1000 ml of desiccated propanol or 1000 ml of desiccated hexanol was used in place of 640 ml of desiccated methanol. The results are shown in Table 1-1 and the analytical results are shown in Table 1-2. No. IR (cm -1 ) Spectra NMR (δ, CDCl 3 ) Spectra Mass (m/z) Spectra 1720 1.10 (t, J=6Hz, 3H), 1.93 275 (M + ) 1 1430 (m, 2H), 2.25 (bs, 1H), 3.11 232 1180 (m, 2H), 3.94 (m, 1H), 4.27 188 1030 (m, 4H), 7.67 (m, 4H) 161 128 1715 0.60-2.30 (m, 14H), 317 (M + ) 2 1440 3.10 (m, 2H), 3.89 (m, 1H), 232 1180 4.25 (s and m, 4H), 188 1020 7.70 (m, 4H) 161 128 Example 4 1,2,3,4-Tetrahydro-benzo[b]furano[2,3-c]pyridine-3-carboxylic acid ethyl ester and 1,2,3,4-tetrahydro-benzo[b]furano[2,3-c]pyridine-3-carboxylic acid propyl ester could be synthesized by following the same procedures as in Example 1 and Example 2, respectively, except that 29.5 g of benzo[b]furan was used in place of 33.6 g of benzo[b]thiophene in the raw materials. The results are shown in Table 2-1 and the analytical results are shown in Table 2-2. No. IR (cm -1 ) Spectra NMR (δ, CDCl 3 ) Spectra Mass (m/z) Spectra 1715 1.41 (t, J=7Hz, 3H), 2.21 (bs, 1H), 3.10 (m, 2H), 3.90 (m, 1H), 4.25 (m, 4H) 7.69 (m, 4H) 245 (M + ) 1 1430 216 1185 172 1020 145 112 1720 1.09 (t, J=6Hz, 3H), 1.93 (m, 2H), 2.25 (bs, 1H), 3.11 (m, 2H), 3.95 (m, 1H), 4.27 (m, 4H), 7.65 (m, 4H) 259 (M + ) 2 1430 216 1175 172 1035 145 112 Example 5 2-(2-Chlorobenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester was obtained by the following method. To 30 ml of chloroform were added 0.60 g of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester synthesized in Example 1, 0,64 ml of triethylamine, and 523 mg of 2-chlorobenzoyl chloride, and the mixture was stirred for one hour at room temperature. The reaction mixture was washed with 30 ml of water and then with 30 ml of an aqueous sodium hydrogencarbonate solution having a pH of 9.0, and also with 30 ml of water. The chloroform layer was dried by sodium sulfate and the solvent was distilled off under reduced pressure to provide 614 mg (yield of 67%) of 2-(2-chlorobenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester. IR (ν max , cm -1 ): 1712, 1638, 1420, 1200, 1024 NMR (δ, CDCl 3 ): 1.17 (t, J=6Hz, 3H), 3.52 (m, 2H), 4.11 (m, 3H), 4.50 (bs, 2H), 7.46 (m, 8H) Mass (m/z): 401, 399, 260, 196, 141, 139, 115, 111 Example 6 2-Acetyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester and 2-(4-methoxybenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester were synthesized using 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester as the starting material by following the same procedure as in Example 5 except that 324 mg of acetic anhydride or 510 mg of 4-methoxybenzoyl chloride, respectively, in place of 614 mg of 2-chlorobenzoyl chloride in Example 5. The results are shown in Table 3-1 and the analytical results are shown in Table 3-2. No. IR (cm -1 ) Spectra NMR ( δ, CDCl 3 ) Spectra Mass (m/z) Spectra 2980, 1.15 (t, J=7Hz, 3H), 2.26 (s, 3H), 3.53 (m, 2H), 4.13 (m, 3H), 4.50 (bs, 2H), 7.55 (m, 4H) 303, 260, 1 1735, 188, 186, 1655, 161, 105 1410, 1200 1720, 1.13 (t, J=7Hz, 3Hz), 3.30 (m, 2H), 3.79 (s, 3H), 4.10 (m, 3H), 4.87 (bs, 2H), 7.13 (m, 8H) 395, 260, 2 1620, 196, 135, 1600, 115 1505, 1415 Example 7 2-(4-Aminobutyroyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester was obtained by the following method. To 5 ml of dimethylformamide were added 392 mg of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester and 441 mg of p-methoxybenzyloxycarbonylaminobutyric acid and after further adding thereto 269 mg of diethyl cyanophosphate and 251 µl of triethylamine, the mixture was stirred for 2 hours at 50°C. After finishing the reaction, 100 ml of ethyl acetate was added to the reaction mixture and the mixture was washed thrice with 100 ml of water. The ethyl acetate layer was concentrated under reduced pressure and subjected to silica gel column chromatography (development solvent: chloroform and methanol of 50:1) to provide 2-[4-(p-methoxybenzoyl)oxycarbonyl-aminobutyroyl]-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester. Then, 5 ml of a mixture of lN hydrochloric acid and ethyl acetate was added to the product and the mixture was stirred for one hour at 50°C and then cooled to provide 315 mg (yield of 54%) of 2-(4-aminobutyroyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester·hydrochloride. IR (ν max , cm -1 ): 1735, 1620, 1435, 1200, 1025 NMR (δ, CDCl 3 ): 1.07 (t, J=6Hz, 3H), 1.09 (m, 2H), 2.83 (m, 4H), 3.37 (m, 1H), 4.03 (m, 4H), 5.20 (m, 6H), 7.53 (m, 6H) Mass (m/z): 346, 329, 260, 188, 186, 160 Example 8 2-(4-Methoxybenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester, 2-methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester, 2-allyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester, 2-benzyl-1,2,3,4-tetrahydro-benzo[b]thieno-[2,3-c]pyridine-3-carboxylic acid ethyl ester, and 2-(4-nitrobenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester were synthesized using 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester as the starting material by following the same procedure as in Example 5 except that 468 mg of 4-methoxybenzyl chloride, 498 mg of methyl iodide, 361 mg of allyl bromide, 511 mg of benzyl bromide, and 646 mg of 4-nitrobenzyl bromide, respectively, were used in place of 614 mg of 2-chlorobenzoyl chloride in Example 5. The results are shown in Table 4-1 and the analytical results are shown in Table 4-2. No. IR (cm -1 ) Spectra NMR (δ, CDCl 3 ) Spectra Mass (m/z) Spectra 1720, 1.22 (t, J=7Hz, 3H), 3.16 (m, 2H), 3.73 (s, 3H), 4.17 (m, 9H), 7.13 (m, 8H) 381, 308, 1 1620, 260, 186, 1600, 160, 121 1505, 1415, 1255 2900, 1.25 (t, J=7Hz, 3H), 2.58 (s, 3H), 3.10 (m, 2H), 3.70 (t, J=6Hz, 1H), 4.17 (m, 6H), 7.37 (m, 4H) 275, 202, 2 1740, 161, 115, 1580, 101 1440, 1200 1735, 1.20 (t, J=7Hz, 3H), 3.27 (m, 5H), 4.06 (m, 5H), 5.40 (m, 3H), 7.37 (m, 4H) 301, 260, 3 1650, 242, 238, 1435, 202, 185, 1200 160, 140 1740, 1.17 (t, J=7Hz, 3H), 3.12 (m, 2H), 4.03 (m, 7H), 7.37 (m, 9H) 351, 278, 4 1440, 260, 196, 1205 160, 115, 91 1740, 1.23 (t, J=7Hz, 3H), 3.27 (m, 2H), 4.07 (m, 7H), 7.60 (m, 8H) 396, 323, 5 1605, 260, 186, 1520, 160, 136, 1440, 115, 106 1350 90 Example 9 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid benzyl ester could be synthesized by following the same procedure as the synthesis of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester in Example 1 except that 19.5 g of benzyl nitroacetate was used in place of 13.3 g of ethyl nitroacetate. The results are shown in Table 5-1 and the analytical results are shown in Table 5-2. No. IR (cm -1 ) Spectra NMR (δ, CDCl 3 ) Spectra Mass (m/z) Spectra 1740, 3.33 (m, 2H), 4.67 (m, 4H), 5.30 (s, 2H), 7.53 (m, 9H) 323, 232, 1 1560, 188, 161, 1430, 128, 115 1265 Example 10 1-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester was synthesized by following the same procedure as the synthesis of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester in Example 1 except that 19.5 g of acetaldehyde was used in place of 10.2 ml of formalin in Example 1. The results are shown in Table 6-1 and the analytical results are shown in Table 6-2. No. IR (cm -1 ) Spectra NMR (δ, CDCl 3 ) Spectra Mass (m/z) Spectra 1725, 1.36 (m, 6H), 2.25 (s, 1H), 3.11 (m, 2H), 4.01 (m, 4H), 7.68 (m, 4H) 275, 260, 1 1620, 196, 135, 1510, 115 1410, 1200 Example 11 4-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester was synthesized by following the same procedure as the synthesis of 1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester in Example 1 except that 23.7 g of ethylideneisopropylamine was used in place of 19.6 g of methylideneisopropylamine. The results are shown in Table 7-1 and the analytical results are shown in Table 7-2. No. IR (cm -1 ) Spectra NMR (δ, CDCl 3 ) Spectra Mass (m/z) Spectra 1720, 1.30 (m, 6H), 2.21 (s, 1H), 3.10 (m, 2H), 4.09 (m, 4H), 7.61 (m, 4H) 275, 260, 1 1610, 196, 135, 1520, 115 1420, 1220 Example 12 6-Chloro-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester was synthesized by following the same procedure as the synthesis of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester in Example 1 except that 42.3 g of 5-chlorobenzothiophene was used in place of 33.6 g of benzothiophene in Example 1. The results are shown in Table 8-1 and the analytical results are shown in Table 8-2. No. IR (cm -1 ) Spectra NMR (δ, CDCl 3 ) Spectra Mass (m/z) Spectra 1725, 1.35 (t, J=6Hz, 3H), 2.25 (s, 2H), 3.10 (m, 2H), 3.85 (m, 1H), 4.31 (q, J=6Hz, 2H), 7.21 (m, 3H) 298, 296, 1 1425, 261, 196, 1195, 135, 115 760, 740 Example 13 Hexahydro-1-(1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-carbonyl)-lH-1,4-diazepine hydrochloride was obtained by the following method. In 20 ml of desiccated chloroform were dissolved 6 g of 1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-caboxylic acid ethyl ester synthesized in Example 1 and 6.63 g of 2-(tertiary-butoxycarbonylthio)-4,6-dimethylpyrimidine, and the solution was refluxed for 30 minutes. After distilling off chloroform under reduced pressure, the residue was dissolved in 300 ml of ethyl acetate and the solution was washed thrice with 50 ml of an aqueous 5% sodium hydrogencarbonate, twice with an aqueous 5% citric acid solution, and then twice with a saturated aqueous sodium chloride solution and thereafter dried with sodium sulfate. Ethyl acetate was distilled off under reduced pressure and the residue was recrystallized from a mixture of chloroform and petroleum ether to provide 6.18 g (yield of 76%) of 2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-carboxylic acid ethyl ester. IR (ν max , cm -1 ): 2970, 1720, 1695, 1400, 760, 740. NMR (δ, CDCl 3 ): 1.10 (t, J=6Hz, 3H), 1.50 (s, 9H), 3.40 (m, 2H), 4.05 (q, J=6Hz, 2H), 4.70 (d, J=9Hz, 2H), 5.10-5.50 (m, 1H), 7.10-7.70 (m, 4H). In a mixed solvent of 30 ml of methanol and 20 ml of chloroform was dissolved 6 g of 2-tert-butoxy-carbonyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-carboxylic acid ethyl ester and 4 ml of an aqueous solution of 5N sodium hydroxide was further added thereto, and then the solution was refluxed for 5 hours. The solvents were distilled off under reduced pressure and 300 ml of 5% citric acid and 300 ml of chloroform were added to the residue. The chloroform layer was washed with a saturated aqueous sodium chloride solution and then dried by sodium sulfate. After distilling off chloroform under reduced pressure, the residue formed was recrystallized from a mixture of chloroform and hexane to provide 4.15 g (yield of 75%) of 2-tert-butoxycarbonyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid. IR (ν max , cm -1 ): 2970, 2860, 1700, 1695, 1400, 760, 740. NMR (δ, CDCl 3 ): 1.50 (s, 9H), 3.40 (s, 2H), 4.60 (d, J=9Hz, 2H), 5.10-5.50 (m, 1H), 7.10-7.70 (m, 4H). In 5 ml of dimethylformamide were dissolved 0.32 g of 2-tert-butoxycarbonyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid and 0.2 g of hexahydro-1H-1,4-diazepine and after adding thereto 3 ml of a dimethylformamide solution of 0.33 g of diphenylphosphorylazide, the mixture was stirred overnight. To the reaction mixture was added 50 g of ethyl acetate and the mixture was washed twice with an aqueous 5% sodium hydrogencarbonate solution and then twice with a saturated sodium chloride solution, and thereafter dried with sodium sulfate. After filtering away sodium sulfate, 5 ml of a mixture of IN hydrochloric acid in ethyl acetate were added to the filtrate and the mixture was heated to 50°C for one hours. After distilling off ethyl acetate under reduced pressure, the residue formed was dissolved in 30 ml of water and the solution was washed thrice with 10 ml of ethyl ether. The aqueous layer was adjusted to pH 12 with an aqueous solution of 5N sodium hydroxide and after adding thereto 1 g of sodium chloride, the reaction mixture was extracted thrice with chloroform. The chloroform layer was dried by magnesium sulfate and then the residue formed was purified by silica gel thin layer chromatography (solvent: ethyl acetate and methanol of 10:1). Then, 2 ml of a mixture of IN hydrochloric acid in ethyl acetate was added to the product and crystals thus deposited were collected by filtration to provide 0.24 g (yield of 62%) of hexahydro-1-(1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine. di-hydrochloride. (See Table 9-1, Table 10-1). By following the same procedure as above using 0.32 g of 2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid and ethylenediamine as the starting materials, 0.19 g (yield of 54%) of N-(2-aminoethyl)-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamide-di-hydrochloride was obtained (see Table 9-1, Table 10-1). Also, by following the same procedure as above using ethylideneisopropylamine in place of methylideneisopropylamine, 0.26 g (yield of 65%) of hexahydro-1-(4-methyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine·di-hydrochloride was obtained (see Table 9-1, Table 10-1). Also, by following the same procedure as above using benzaldehyde and 50 equivalents of hydrogenchloride in place of formalin, 0.33 g (yield of 71%) of hexahydro-1-[1-phenyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)-lH-1,4-diazepine-di-hydrochloride was obtained (see Table 9-1, Table 10-1). Also, by following the same procedure as above using 5-chlorobenzo[b]thiophene in place of benzo[b]thiophene, 0.22 g (yield of 53%) of hexahydro-1-(6-chloro-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)-lH-1,4-diazepine-di-hydrochloride was obtained (see Table 9-1, Table 10-1). No. Mass Spectra (m/z) IR Absorption Spectra (ν max , cm -1 ) NMR Spectra 1 315 (M + ) 3400, 2920 (δ, d 6 -DMSO) 1.80-2.30 (br, 2H), 2.80-4.20 (dr, 10H), 4.30-5.00 (br, 2H), 7.30-7.60 (m, 2H), 7.60-8.20 (m, 2H) 215 2800, 1640 188 1430, 760 740 2 275 (M + ) 3240, 3110 (δ, d 6 -DMSO) 2.70-3.60 (br, 4H), 3.50 (s, 2H), 4.00-4.60 (br, 3H), 7.30-7.50 (m, 2H), 7.50-8.00 (m, 2H), 8.10-8.90 (m, 2H), 9.00-9.80 (br, 2H) 216 3000, 1670 188 1540, 1430 760, 740 3 330 (M + ) 3400, 2970 (δ, d 6 -DMSO) 1.15 (d, J=6Hz, 3H), 1.80-2.20 (br, 2H), 2.8-4.20 (br, 9H), 4.30-4.90 (br, 3H), 7.30-7.60 (m, 2H), 7.60-8.20 (m, 2H) 231 2920, 2820 203 1650, 1430 760, 740 4 392 (M + ) 3400, 2970 (δ, d 6 -DMSO) 1.80-2.20 (br, 2H), 2.80-4.20 (br, 10H), 4.30-5.10 (br, 2H), 7.30 (s, 5H), 7.30-7.60 (m, 2H), 7.60-8.20 (m, 2H) 295 1640, 1260 265 1200, 760 750, 740 5 350(M + ) 3400, 2920 (δ, d 6 -DMSO) 1.70-2.30 (br, 2H), 2.70-4.25 (br, 10H), 4.30-5.00 (br, 3H), 7.40-7.50 (m, 1H), 7.50 (s, 1H), 7.80-8.00 (m, 1H) 251 2800, 1640 223 1430, 1090 760, 740 Example 14 N-Methyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamide·hydrochloride was obtained by the following method. In 5 ml of dimethylformamide were dissolved 0.32 g of 2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid, 0.08 g of methylamine·hydrochloride, and 0.17 ml of triethylamine, and after adding dropwise thereto 5 ml of a dimethylformamide solution of 0.33 g of diphenylphosphorylazide under ice-cooling and further adding dropwise thereto 2 ml of a dimethylformamide solution of 0.17 ml of triethylamine, the mixture was stirred for 2 hours at room temperature. To the reaction mixture was added 50 ml of ethyl acetate and the mixture was washed thrice with 10 ml of an aqueous 5% citric acid solution, thrice with an aqueous 5% sodium hydrogencarbonate solution and then twice with a saturated sodium chloride solution, and thereafter dried with sodium sulfate. After filtering away sodium sulfate, 5 ml of a mixture of IN hydrochloric acid in ethyl acetate were added to the filtrate and the mixture was heated to 50°C for one hour. Then, the reaction mixture was allowed to stand overnight in a refrigerator and crystals thus deposited were collected by filtration to provide 0.23 g (yield of 65%) of N-methyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamide. (See Table 11, Table 12). By following the same procedure as above using 2-tert-butoxycarbonyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid as the starting material, N-ethyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamide-hydrochloride, 4-(1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine·hydrochloride, N-(4-morpholino)-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamide-hydrochloride, 1-(1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)-4-pyrimidinylpiperazine-hydrochloride, and 4-(1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamino)-butyric acid ethyl ester-hydrochloride were obtained. (See Table 11, Table 12). No. Mass Spectra (m/z) IR Absorption Spectra (ν max , cm-1) NMR Spectra (δ) 1 246 (M + ) 3300, 3210 (CDCl 3 ), 1.65 (s, 1H), 2.85 (d, J=5Hz, 3H), 3.10-3.20 (br, 1H), 3.40-3.70 (br, 2H), 4.10 (d, J=2Hz, 2H), 6.90-7.20 (br, 1H), 7.20-7.50 (m, 2H), 7.50-7.90 (m 2H) 231 3060, 2920 188 1650, 1560 1010, 760 740 2 260 (M + ) 3400, 3200 (d 6 -DMSO), 1.10 (t, J=7Hz, 3H), 2.90-3.50 (br, 4H), 4.15-4.30 (br, 1H), 4.40 (s, 2H), 7.20-7.50 (m, 2H), 7.50-8.00 (m, 2H), 8.90 (m, 1H) 231 3070, 2970 188 1670, 1560 1440, 760 740 3 317 (M + ) 3400, 2920 (CDCl 3 , free compound), 2.10 (s, 1H), 2.80 (dd, JA=7Hz, JB=1Hz, 2H), 3.60 (s, 8H), 3.70-3.90 (br, 1H), 4.05 (s, 1H), 7.10-7.70 (m, 4H) 231 1650, 1420 188 1110, 760 740 4 332 (M + ) 3410, 2920 (CDCl 3 , free compound), 1.80 (s, 1H), 2.60-3.10 (br, 6H), 3.40-4.00 (br, 5H), 4.05 (s, 2H), 7.10-7.50 (m, 2H), 7.50-7.90 (m, 2H) 246 1690, 1420 231 1270, 1110 188 760, 740 5 394 (M + ) 3430, 2900 (d 6 -DMSO), 3.00-3.45, (br, 6H), 3.50-4.00 (br, 5H), 4.10 (s, 2H), 6.60 (t, J=5Hz, 1H), 7.20-7.50 (m, 2H), 7.60-7.95 (m, 2H), 8.30 (s, 1H), 8.40 (s, 1H) 315 1640, 1580 231 1550, 1430 188 1010, 980 6 346 (M + ) 3300, 2970 (CDCl 3 , free compound), 1.10 (t, J=7Hz, 3H), 1.50-2.00 (br, 3H), 2.30 (t, J=6Hz, 2H), 2.50-3.60 (br, 5H), 3.60-4.30 (m, 4H), 6.90-8.00 (m, 5H) 273 2940, 2880 231 1730, 1640 188 1555, 1180 760, 740 Example 15 4-(1,2,3,4-Tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid was obtained by the following method. In 2 ml of ethanol was dissolved 400 mg of 4-(1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid ethyl ester and after adding thereto 1.5 ml of an aqueous IN sodium hydroxide solution, the mixture was stirred for 5 hours at room temperature. Ethanol was distilled off under reduced pressure, 100 ml of water was added to the residue, and after adjusting the pH thereof to 5 by IN hydrochloric acid, the mixture was stirred overnight. Precipitates thus deposited were collected by filtration to provide 305 mg (yield of 82%) of 4-(1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid. IR (ν max , cm -1 ): 3430, 3250, 3100, 2920, 1660, 1570, 1430 NMR (δ, CDCl 3 ): 1.50-2.00 (br, 3H), 2.00-2.60 (br, 2H), 4.00 (s, 2H), 5.80-6.50 (br, 2H), 7.20-7.50 (m, 2H), 7.50-8.00 (m, 2H). Example 16 4-(2-Methyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)morpholine-hydrochloride was synthesized by the following method. In 5 ml of chloroform were dissolved 0.34 g of 4-(1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)morpholine·hydrochloride, 0.31 ml of triethylamine, and 0.11 g of methyl bromide, and the solution was refluxed for 30 minutes. Chloroform was distilled off under reduced pressure, 20 ml of an aqueous 5% sodium hydrogencarbonate solution and 50 ml of ethyl acetate were added to the residue, and the ethyl acetate layer was washed with a saturated sodium chloride solution and dried by sodium sulfate. Then, ethyl acetate was distilled under reduced pressure and the residue was purified by silica gel thin layer chromatography. Then, 1 ml of a mixture of IN hydrochloric acid in ethyl acetate was added to the residue and crystals deposited were collected by filtration to provide 0.29 g (yield of 82%) of 4-(2-methyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)morpholine·hydrochloride. IR (ν max , cm -1 ): 3400, 2970, 2900, 1655, 1420, 1110, 760, 740 NMR (δ, CDCl 3 , free compound): 2.80 (d, J=7Hz, 2H), 2.90 (s, 8H), 3.60 (s, 8H), 3.60 (s, 8H), 3.70-3.90 (m, 1H), 4.05 (s, 1H), 7.10-7.70 (m, 4H). Example 17 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)piperidine was synthesized by the following method. In a mixed solvent of 900 ml of xylene and 100 ml of dioxane was dissolved 14.64 g of 1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid methyl ester synthesized in Example 2, and after adding thereto 41 g of sulfur powder, the mixture was refluxed for 5 days. After the reaction was over, the solvents were distilled off under reduced pressure and the residue was washed several times with methanol on a glass filter. Methanol was distilled off under reduced pressure, the residue was dissolved in chloroform, and the solution was washed with an aqueous 5% citric acid solution, an aqueous 5% sodium hydrogencarbonate solution, and then a saturated sodium chloride solution. The chloroform layer was dried by sodium sulfate and chloroform was distilled off under reduced pressure. The residue formed was recrystallized from a mixture of chloroform and ether to provide 12.4 g (yield of 86%) of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid methyl ester. IR (ν max , cm -1 ): 2950, 1720, 1600, 1520 NMR (δ, CDCl 3 ): 4.51 (s, 3H), 7.50-8.50 (m, 4H), 8.91 (s, 1H), 9.33 (s, 1H). Mass (m/z): 243 (M + ), 212, 184. In 200 ml of methanol was dissolved 12.16 g of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid methyl ester and after adding thereto 55 ml of a methanol solution of IN sodium hydroxide, the mixture was refluxed for 30 minutes. After allowing the temperature to lower to room temperature, the mixture was allowed to stand overnight in a refrigerator and crystals thus deposited were collected by filtration. The crystals were suspended in water and after adjusting the pH thereof to from 2 to 3 with IN hydrochloric acid, the suspension was stirred for a whole day and night at room temperature. Precipitates thus formed were collected by filtration to provide 10.2 g (yield of 88%) of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid. IR (ν max , cm -1 ): 1700, 1600, 1570, 1530 NMR (δ, d-DMSO): 7.60-7.90 (m, 2H), 8.10-8.40 (m, 1H), 8.60-8.80 (m, 1H), 9.07 (s, 1H), 9.51 (s, 1H) Mass (m/z): 229 (M + ), 185, 158, 140. In 5 ml of dimethylformamide were dissolved 458 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid and 170 mg of piperidine, and 660 mg of DPPA (diphenylphosphorylazide) was added dropwise to the solution under ice-cooling. Then, 335 µl of triethylamine was added to the mixture and the resultant mixture was stirred overnight at room temperature. After the reaction was over, the reaction mixture was diluted with ethyl acetate and the solution was washed with an aqueous 5% citric acid solution, an aqueous 5% sodium hydrogencarbonate solution, and then a saturated aqueous sodium chloride solution and thereafter dried with Galuber's salt. The ethyl acetate layer was concentrated under reduced pressure and the residue was purified by silica gel thin layer chromatography (solvent: chloroform) and then recrystallized from a mixture of chloroform and ether to provide 230 mg (yield of 85%) of 1-(benzc[b]thieno[2,3-c]pyridine-3-carbonyl)-piperidine. IR (ν max , cm -1 ): 2950, 2830, 1630, 1600, 1480, 1440 NMR (δ, CDCl 3 ): 1.30-2.00 (br, 6H), 3.40-4.15 (br, 4H), 7.50-7.80 (m, 2H), 7.90-8.10 (m, 1H), 8.15-8.40 (m, 1H), 8.42 (s, 1H), 9.14 (s, 1H). Mass (m/z): 296 (M + ), 212, 185, 113, 84 By following the same procedure as above using benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid as the starting material, 1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-2,6-dimethyl-piperidine and 4-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine were obtained. (See Table 13-1, Table 13-2, Table 13-3). Solvent Reaction Temperature Reaction Time Amount of Product (yield) 1 Dimethyl-formamide 15-25°C 14 hours 422 mg (65%) 2 " " 5 hours 537 mg (90%) No. Mass Spectra (m/z) IR Absorption Spectra (ν max , cm -1 ) NMR Spectra (CDCl 3 ) 1 324, 309 2930, 1620 254, 212 1600, 1520 185, 140 1420 112 1.27 (d, 6H), 1.10-2.00 (br, 6H), 4.30-4.90 (br, 2H), 7.50-7.80 (m, 2H), 7.90-8.10 (m, 1H), 8.15-8.50 (m, 2H), 9.13 (s, 1H) 2 298, 212 2950, 2850 185, 133 1630, 1600 86 1430 3.60-4.10 (br, 8H), 7.50-7.80 (m, 2H), 7.90-8.10 (m, 1H), 8.15-8.40 (m, 1H), 8.59 (s, 1H), 9.14 (s, 1H) Example 18 Hexahydro-1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine was obtained by the following method. In 5 ml of dimethylformamide were dissolved 458 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid and 200 mg of hexahydro-1H-1,4-diazepine and after adding dropwise to the solution 660 mg of diphenylphosphorylazide (DPPA) under ice-cooling and then adding thereto 200 mg of hexahydro-1H-1,4-diazepine, the mixture was stirred overnight at room temperature. After the reaction was over, water and sodium hydrogencarbonate were added to the reaction mixture and after adjusting the pH thereof to 10, the reaction mixture was extracted with 50 ml of ethyl acetate. The ethyl acetate extract was washed with a saturated aqueous sodium chloride solution and dried by sodium sulfate Ethyl acetate was distilled off under reduced pressure and purified by silica gel thin layer chromatography (developing solution: chloroform:methanol: aqueous ammonia of 90:10:2). Furthermore, the product was dissolved in 20 ml of ethyl acetate and after adding thereto 1.5 ml of a mixture of 1.3N hydrochloric acid and ethyl acetate, crystals thus deposited were collected by filtration to provide 520 mg (yield of 74%) of the desired product. IR (ν max , cm -1 ): 3300, 2900, 2730, 1620, 1580, 1420 NMR (δ, d-DMSO): 1.90-2.20 (br, 2H), 3.10-3.40 (br, 8H), 7.60-7.90 (m, 2H), 8.10-8.40 (m, 1H), 8.50-8.80 (m, 1H), 8.85 (s, 1H), 9.50 (s, 1H). By following the same procedures as above using benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid as the starting material, 1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-piperazine, 1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-3-methylpiperazine, 1-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-4-methylpiperazine, and hexahydro-1-[benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-4-methyldiazepine were obtained. (See Table 14-1, Table 14-2, Table 14-3). Solvent Reaction Temperature Reaction Time Amount of Product (yield %) 1 Dimethyl-formamide 15-25°C 14 hours 494 mg (74%) 2 " " 16 hours 495 mg (66%) 3 " " 3 hours 690 mg (92%) 4 " " 6 hours 692 mg (89%) No. Mass Spectra (m/z) IR Absorption Spectra (Vmax, cm -1 NMR Spectra (d 6 -DMSO) 1 297, 254 2950, 2450 212, 185 1630, 1600 85 1440 3.30-3.50 (br, 4H), 3.90-4.20 (br, 4H), 7.60-7.90 (m, 2H), 8.05-8.30 (m, 1H), 8.45-8.60 (m, 1H), 8.66 (s, 1H), 9.30 (s, 1H) 2 311, 254 2700, 2450 212, 185 1620, 1580 99 1420 1.33-1.66 (m,3H), 3.40-3.90 (br, 7H), 7.70-7.90 (m, 2H), 8.10-8.30 (m, 1H), 8.45-8.60 (m, 1H), 8.72 (s, 1H), 9.32 (s, 1H) 3 311, 254 3400, 2650, 241, 212 1630, 1420 2.88 (s, 3H), 3.05-4.05 (br, 7H), 7.70-7.90 (m, 2H), 8.10-8.30 (m, 1H), 8.45-8.60 (m, 1H), 8.72 (s, 1H), 9.32 (s, 1H) 185, 99 4 325, 254 2800, 2660 212, 185 1630, 1430 140, 113 1.90-2.20 (br, 2H), 2.83 (s, 3H), 3.05-3.70 (br, 8H), 7.70-7.90 (m, 2H), 8.10-8.30 (m, 1H), 8.60-8.80 (m, 1H), 8.90 (s, 1H), 9.45 (s, 1H) Example 19 N-(2-Aminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide·hydrochloride was synthesized by the following method. In 10 ml of dimethylformamide (DMF) were suspended 487 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid synthesized in Example 17 and 508 mg of benzyloxycarbonylethylenediamine hydrochloride (Z-NHC 2 H 4 NH 2 ·HCl), and after adding thereto 307 µl of triethylamine, the mixture was cooled to 0°C. Then, 660 mg of diphenylphosphorylazide (DPPA) and 336 µl of triethylamine were added thereto and the mixture was stirred for one hour under ice-cooling and stirred overnight at room temperature. The reaction mixture was diluted with 200 ml of ethyl acetate, washed with an aqueous 5% citric acid solution, an aqueous 5% sodium hydrogencarbonate solution, and then a saturated aqueous sodium chloride solution, and then dried by sodium sulfate. Then, ethyl acetate was distilled off under reduced pressure, the residue was dissolved in 10 ml of acetic acid and after adding thereto 5 ml of an acetic acid solution of 25% hydrogen bromide, the mixture was stirred for 2 hours at 50°C. The reaction mixture was diluted with 200 ml of water and washed twice with ether. After adjusting the pH thereof to 11 with sodium hydroxide, the reaction mixture was extracted thrice with chloroform and the extract was dried by sodium sulfate. Chloroform was distilled off under reduced pressure and the residue was diluted with 100 ml of ethyl acetate. Then, 2 ml of a mixture of IN hydrochloric acid in ethyl acetate was added dropwise to the residue and crystals thus deposited were collected by filtration to provide 230 mg (yield of 37%) of N-(2-aminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide-hydrochloride. IR (ν max , cm -1 ): 3320, 2950, 2900, 1650, 1520, 1240, 760, 740 NMR (δ, d 6 -DMSO): 2.90-3.40 (m, 2H), 3.50-3.90 (m, 2H), 7.50-7.90 (m, 4H), 8.10-8.30 (m, 1H), 8.30-8.70 (m, 2H), 9.30 (s, 1H), 9.50 (s, 1H) Mass (m/z): 271 (M + ), 252, 242, 229, 185, 140 Also, by following the same procedure as above using benzyloxycarbonyltrimethylenediamine in place of benzyloxycarbonylethylenediamine, N-(3-aminopropyl)benzo[b]thieno[2,3-c]pyridine-3-carboamide was obtained. Also, by following the same procedure as above using ethylideneisopropylamine in place of methylideneisopropylamine, N-(2-aminoethyl)4-methyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide was obtained. Also, by following the same procedure as above using 5-chlorobenzo[b]thiophene in place of benzo[b]thiophene, N-(2-aminoethyl)-6-chlorobenzo[b]thieno[2,3-c]pyridine-3-carboamide was obtained. Also, by following the same procedure as above using benzo[b]furan in place of benzo[b]thiophene, N-(2-aminoethyl)benzo[b]furano[2,3-c]pyridine-3-carboamide was obtained. Also, by following the same procedure as above using benzaldehyde in place of formalin in the cyclization reaction and adjusting the pH to 2 with hydrochloric acid, N-(2-aminoethyl)-1-phenylbenzo[b]thieno[2,3-c]pyridine-3-carboamide was obtained. The amounts of the final products and the yields thereof in the final steps are shown in Table 15-1 and the analytical results are shown in Table 15-2: No. IR (ν max , cm -1 ) NMR (δ, d 6 -DMSO) Mass (m/z) 1 3400, 3200 1.80-2.20 (m, 2H), 2.60- 285 (M + ) 3000, 1680 3.20 (m, 2H), 3.30-3.70 242, 229, 1580, 1330 (m, 2H), 7.50-7.80 (m, 2H), 212, 199, 780, 740 8.00-8.50 (m, 3H), 8.50-8.80 (m, 1H), 9.30 (s, 1H), 9.45 (s, 1H) 185, 140 2 3400, 3200 2.60 (s, 3H), 2.90-3.40 285 (M + ) 3000, 2900 (m, 2H), 3.50-3.90 (m, 2H), 266, 256, 1680, 1570 7.50-7.80 (m, 2H), 8.10- 243, 200 1320, 760 8.30 (m, 1H), 8.30-8.80 (m, 740 3H), 9.30 (s, 1H), 9.50 (s, 1H) 3 3400, 3200 2.90-3.40 (m, 2H), 3.50- 306 (M + ) 3000, 1670 3.90 (m, 2H),7.50-7.80 289, 277, 1570, 1330 (m, 1H), 8.10-8.20 (m, 221 1080, 760 1H), 8.35 (d, J=8Hz, 740 1H), 9.35 (s, 1H), 9.60 (s, 1H) 4 3400, 3200 2.90-3.40 (m, 2H), 3.50- 255 (M + ) 2950, 1670 3.95 (m, 2H), 7.20-7.50 236, 226, 1580, 1330 (m, 2H), 7.80-8.10 (m, 170 770, 750 1H), 8.20-8.50 (m, 3H), 9.10 (s, 1H), 9.30 (s, 1H) 5 3400, 3100 2.90-3.40 (m, 2H), 3.50- 347 (M + ) 2950, 2900 3.90 (m, 2H), 7.30 (s, 290, 262, 1680, 1600 5H), 7.50-7.90 (m, 2H), 185 1300, 760 8.00-8.50 (s, 3H), 8.50- 730 8.70 (m, 1H), 9.20 (s, 1H) Example 20 Benzo[b]thieno[2,3-c]pyridine-3-carboamide was obtained by the following method. In 30 ml of ethanol was dissolved 487 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester and ammonia gas was slowly blown into the solution for 15 minutes under ice-cooling. After allowing the solution to stand for 3 days at room temperature, crystals thus deposited were collected by filtration to provide 410 mg (yield of 89%) of benzo[b]thieno[2,3-c]pyridine-3-carboamide. IR (ν max , cm -1 ): 3400, 3280, 3160, 1685, 1600, 1530, 1420, 1360, 720 NMR (δ, d 6 -DMSO): 7.50-7.90 (m, 2H), 8.00-8.30 (m, 1H), 8.50-8.80 (m, 1H), 8.95 (s, 1H), 9.30 (s, 1H) Mass (m/z): 227 (M+), 185, 158, 140 Example 21 Benzo[b]thieno[2,3-c]pyridine-3-carbohydrazide was obtained by the following method. In 20 ml of desiccated methanol was dissolved 515 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester and after adding thereto 252 mg of hydrazine·di-chloride and 700 µl of triethylamine, the mixture was stirred for 2 days. Then, after refluxing the mixture for 2 hours, the temperature was allowed to lower to room temperature and crystals thus deposited were collected by filtration to provide 169 mg (yield of 30%) of benzo[b]thieno[2,3-c]pyridine-3-carbohydrazide. IR (ν max , cm -1 ): 3400, 1690, 1570, 1320, 740 NMR (δ, d 6 -DMSO): (hydrochloride): 5.80-7.20 (br, 3H), 7.50-7.90 (m, 2H), 8.10-8.40 (m, 1H), 8.60-8.80 (m, 1H), 9.10 (s, 1H), 9.50 (s, 1H) Mass (m/z): 243, 212, 184, 140 Example 22 N-(2-Dimethylaminoethyl]-benzo[b]thieno[2,3-c]pyridine-3-carboamide-hydrochloride was obtained by the following method. In 10 ml of dimethylformamide were dissolved 487 mg of benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid and 212 mg of N,N-dimethylethylenediamine and after adding thereto 660 mg of DPPA and 335 µl of triethylamine, the mixture was stirred overnight at room temperature. The reaction mixture was diluted with 100 ml of ethyl acetate, washed twice with an aqueous IN sodium hydroxide solution, and dried by sodium sulfate. After distilling off ethyl acetate under reduced pressure, the residue was purified by silica gel column chromatography (ethyl acetate:ethanol:aqueous ammonia of 10:3:1). Furthermore, the product was diluted with 50 ml of ethyl acetate and after adding thereto 2 ml of a mixture of IN hydrochloric acid in ethyl acetate, crystals thus, deposited were collected by filtration to provide 570 mg (yield of 85%) of N-(2-dimethylaminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide·hydrochloride. IR (ν max , cm -1 ): 3300, 2950, 1660, 1600, 1420, 1320, 1010, 760, 730 NMR (δ, d 6 -DMSO): 2.90 (s, 6H), 3.00-3.40 (m, 2H), 3.50-3.80 (m, 2H), 7.60-7.90 (m, 2H), 8.20-8.40 (m, 1H), 8.60-8.80 (m, 1H), 9.10 (s, 6H), 9.50 (s, 6H). Mass (m/z): 299(M + ), 229, 212, 184, 140 Example 23 N-Methyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide was synthesized by the following method. In 5 ml of dimethylformamide were suspended 459 mg of methyl-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid and 162 mg of methylamine and then 307 µl of triethylamine was added to the solution. Then, after slowly adding dropwise 660 mg of DPPA and then 335 µl of triethylamine under ice-cooling, the mixture was stirred for 3 hours. The reaction mixture was diluted with 50 ml of ethyl acetate and after separating the ethyl acetate layer by an ordinary method, the product was purified by silica gel thin layer chromatography (chloroform:methanol of 30:1) and further recrystallized from a mixture of ethyl acetate and hexane to provide 434 mg (yield of 89%) of N-methyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide. IR (ν max , cm -1 ): 3400, 3300, 3050, 2950, 1660, 1520, 1320, 1230, 770, 730 NMR (δ, CDCl 3 ): 3.05 (d, J=5Hz, 3H), 7.50-7.80 (m, 2H), 7.80-8.00 (m, 1H), 8.00-8.20 (m, 2H), 8.80 (s, 1H), 8.90 (s, 1H) Mass (m/z): 242 (M + ), 213, 185, 140 Also by following the above procedure using ethylamine·p-toluenesulfonate, propylamine-hydrochloride, n-hexylamine·hydrochloride, or 4-aminobutyric acid ethyl ester·hydrochloride in place of methyl-amine-hydrochloride, N-ethyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide, N-propyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide, N-hexyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide, or 4-(benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid ethyl ester was obtained. The reaction conditions, the amounts of the products, and the yields thereof are shown in Table 16-1 and the analytical data are shown in Table 16-2. No. IR (ν max , cm -1 ) NMR (δ, CDCl 3 ) Mass (m/z) 6 3400, 3300, 1.10 (t, J=7Hz, 3H), 3.60 (q, J=7Hz, 2H), 7.50-7.80 (m, 2H), 7.80-8.00 (m, 1H), 8.10-8.40 (m, 2H), 8.80 (s, 1H), 8.90 (s, 1H) 256 (M + ) 3050, 2950, 212, 185, 2920, 2860, 140 1660, 1600, 1310, 780, 760, 720 7 3370, 3300, 1.10 (t, J=7Hz, 3H), 1.20-1.98 (m, 2H), 3.68 (t, J= 7Hz, 2H), 7.80-8.02 (m, 1H), 8.12-8.38 (m, 2H), 8.78 (s, 1H), 8.88 (s, 1H) 268 (M + ) 3040, 2940, 256, 212, 2920, 2840, 185, 140 1650, 1600, 1310, 775 755, 720 8 3360, 3050, 1.10 (t, J=6Hz, 3H), 1.20-2.00 (m, 10H), 3.70 (dd, J=6Hz, J=2Hz), 7.50-7.80 (m, 2H), 7.50-8.00 (m, 1H), 8.10-8.50 (m, 2H), 8.90 (s, 1H), 9.05 (s, 1H) 312 (M + ) 2920, 2850, 241, 212, 1660, 1595, 185, 140 780, 760, 720 1500, 1300, 9 3350, 3050, 1.10 (t, J=7Hz, 3H), 1.90-2.20 (m, 2H), 2.30-2.60 (m, 2H), 3.60 (t, J=6Hz, 2H), 4.30 (q, J=7Hz, 2H), 7.55-7.80 (m, 2H), 7.90-8.10 (m, 1H), 8.10-8.50 (m, 2H), 9.00 (s, 1H), 9.15 (s, 1H) 342 (M + ) 2940, 2870, 297, 255, 1720, 1640, 241, 212, 1520, 1230, 185, 140 780, 760, 730 Example 24 4-(benzo[b]thieno[2,3-c]pyridine-3-carboamido)butyric acid was obtained by the following method. In 50 ml of ethanol was dissolved 3.42 g of 4-benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid ester and after adding thereto 2 ml of an aqueous 6N sodium hydroxide solution, the mixture was refluxed for 30 minutes. Methanol was distilled off under reduced pressure, water was added to the residue, and after adjusting the pH to 3 with citric acid, the product formed was extracted twice with chloroform. After drying the chloroform layer with sodium sulfate, the chloroform layer was concentrated under reduced pressure and crystals thus formed were collected by filtration and recrystallized from a mixture of chloroform and ether to provide 2.55 g (Yield of 81%) of 4-(benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid. IR (ν max , cm -1 ): 3350, 3050, 2900, 2850, 1700, 1640, 1020, 790, 740 NMR (δ, d 6 -DMSO): 1.70-2.10 (m, 2H), 2.10-2.50 (m, 2H), 3.30-3.60 (m, 2H), 7.50-7.90 (m, 2H), 8.00-8.20 (m, 1H), 8.30-8.80- (m, 2H), 9.00 (s, 1H), 9.30 (s, 1H) Mass (m/z): 314(M + ), 255, 241, 212, 185, 140 The novel compounds of this invention are useful as medicaments and in the case of central nervous system diseases, the compounds may be administered orally or by intravenous injection. Generally, 10 to 300 mg of the compound can be administered at a single dose or by dividing into two or three doses per day for adult. The administration period is a continuous administration of several days to 6 months and the doses and the administration period are changed according to the state of patient. Also, the novel compounds of this invention may be used together with other medicaments according to the state of patient. For example, in the case of central nervous system diseases, the compounds of this invention may be used with an antianxiety drug, an antidepressive drug, a brain metabolism activator, a brain circulation improving drug, etc. The compounds of this invention show the following specific antianxiety activity and learning improvement activity. The antianxiety activity and the learning improvement activity of the compounds of this invention were determined using male Wister rats (6 weeks age) and also using a water lick conflict test referring to J.R. Vogel, B. Beer, and D.E. Clody, Psychopharmacologia , 21 , 1-7 (1971). In the test, rats having abstained from water were used, and an electric shock was applied to the rats every time the rats drank water to bring the rats into an anxious state. Thus, the activity of medicaments to the rats was determined. (1) Antianxiety Activity: Rats, having abstained from water for 24 hours before the test, were allowed access to water. After 4 to 5 hours, a medicament was administered. After 15 minutes of treatment time, the test was started. The shocked number is the number of electric shocks received by the rats for 5 minutes after initially allowing them access to water, and shows whether or not the anxiety of receiving electric shock upon drinking the water is restrained. That is, an increase of the shocked number means that the antianxiety activity is increased. The values thereof when the shocked number of the rat administered with no medicament was defined as 100 are shown in Table 17. (n=5) Compound Dose (mg/kg) Route Shocked No. 1,2,3,4-Tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid methyl ester 10 i.v. 390±84 1,2,3,4-Tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 450±61 1,2,3,4-Tetrahydrobenzo[b]furano[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 401±74 1,2,3,4-Tetrahydrobenzo[b]furano[2,3-c]pyridine-3-carboxylic acid propyl ester 10 i.v. 389±72 2-(2-Chlorobenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 211±40 2-Acetyl-1,2,3,4-tetra-hydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 209±45 2-(4-Methoxybenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 195±40 2-(4-Aminobutyloyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 180±32 2-(4-Methoxybenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 227±51 2-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 241±47 2-Allyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 199±22 2-Benzyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 211±30 2-(4-Nitrobenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 219±41 * 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 198±28 * 1-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 205±45 * 4-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 192±30 6-Chloro-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 243±47 " 20 p.o. 207±36 Hexahydro-1-(1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine· di-hydrochloride 10 i.v. 253±8 N-(2-Aminoethyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbo-amide·di-hydrochloride 10 i.v. 211±47 Hexahydro-1-(4-methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine-di-hydrochloride 10 i.v. 192±48 Hexahydro-1-(1-phenyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine·di-hydrochloride 10 i.v. 193±56 Hexahydro-1-(6-chloro-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine-di-hydrochloride 10 i.v. 248±60 N-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbo-amide·hydrochloride 10 i.v. 223±58 N-Ethyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbo-amide·hydrochloride 10 i.v. 201±27 4-(1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine·hydrochloride 10 i.v. 239±39 N-(4-Morpholino)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbo-amide-di-hydrochloride 10 i.v. 219±39 1-(1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-4-pyrimidinyl-piperazine-hydrochloride 10 i.v. 231±41 4-(1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamino)-butyric acid ethyl ester-hydrochloride 10 i.v. 202±29 4-(1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamino)-butyric acid 10 i.v. 219±30 4-(2-Methyl-1,2,3,4-tetra-hydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine-hydrochloride 10 i.v. 197±19 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-piperazine 10 i.v. 294±63 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-3-methylpiperazine 10 i.v. 263±60 Hexahydro-1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine 10 i.v. 318±34 N-propyl-benzo[b]thieno[2,3-c]pyridine-3-carboamide 10 i.v. 206±33 N-(3-Aminopropyl)benzo-[b]thieno[2,3-c]pyridine-3-carboamide 10 i.v. 313±48 4-(Benzo[b]thieno[2,3-c]pyridine-3-carboamino)butyric acid ethyl ester 10 i.v. 309±42 N-(2-Aminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide 10 i.v. 299±29 (2) Learning Improvement Activity: This test was performed simultaneously with the measurement of the antianxiety activity (1) and represents the latent time when the rats' abstinence from water first began to when the rat drank water, was measured. A longer latent time means the higher the learning improvement activity. The values of latent time, with the average value of the rats administrated with no medicament being defined as 100, are shown in Table 18. (n=15) It has been shown that the compounds of this invention effectively prolong the latent time and thus have learning improvement activity. Thus, the compounds of this invention can be used as an antianxiety drug and as an antidementia drug. Compound Dose (mg/kg) Route Latent Time 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid methyl ester 10 i.v. 221±18 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 312±48 1,2,3,4-Tetrahydro-benzo[b]furano[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 259±38 1,2,3,4-Tetrahydro-benzo[b]furano[2,3-c]pyridine-3-carboxylic acid propyl ester 10 i.v. 309±42 2-(2-Chlorobenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 198±40 2-Acetyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 211±51 2-(4-Methoxybenzoyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 213±45 * 2-(4-Aminobutyloyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 189±22 * 2-(4-Methoxybenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 211±49 2-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 231±51 2-Allyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 195±33 2-Benzyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 196±22 2-(4-Nitrobenzyl)-1,2,3,4-tetrahydro-benzo[b]thieno-[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 198±39 1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboxylic acid benzyl ester 10 i.v. 213±42 1-Methyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 231±45 4-Methyl-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 211±33 6-Chloro-1,2,3,4-tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester 10 i.v. 195±27 Hexahydro-1-(1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine-di-hydrochloride 10 i.v. 211±53 N-(2-Aminoethyl)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamide-di-hydrochloride 10 i.v. 229±41 Hexahydro-1-(4-methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine-di-hydrochloride 10 i.v. 197±31 Hexahydro-1-(1-phenyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine·di-hydrochloride 10 i.v. 181±18 Hexahydro-1-(6-chloro-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-1H-1,4-diazepine-di-hydrochloride 10 i.v. 251±55 N-Methyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbo-amide-hydrochloride 10 i.v. 178±41 N-Ethyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamide-hydrochloride 10 i.v. 153±18 4-(1,2,3,4-Tetrahydrobenzo[b]thieno[2,3-c]-pyridine-3-carbonyl)-morpholine·hydrochloride 10 i.v. 194±21 N-(4-Morpholino)-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carboamide-di-hydrochloride 10 i.v. 266±108 1-(1,2,3,4-Tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carbonyl)-4-pyrimidinyl-piperazine-hydrochloride 10 i.v. 187±58 4-(1,2,3,4-Tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamino)-butyric acid ethyl ester-hydrochloride 10 i.v. 202±73 4-(1,2,3,4-Tetrahydrobenzo[b]thieno[2,3-c]pyridine-3-carboamino)-butyric acid 10 i.v. 262±102 4-(2-Methyl-1,2,3,4-Tetrahydro-benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine-hydrochloride 10 i.v. 214±72 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-piperidine 10 i.v. 391±69 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-2,6-dimethylpiperidine 10 i.v. 235±55 1-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-4-methylpiperazine 10 i.v. 216±52 Hexahydro-1-(benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-lH-4-methyldiazepine 10 i.v. 221±18 4-(Benzo[b]thieno[2,3-c]pyridine-3-carbonyl)-morpholine 10 i.v. 610±110 N-(2-Aminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide 10 i.v. 312±52 N-Methyl-benzo[b]thieno[2,3-c]pyridine-3-carboamido 10 i.v. 223±23 N-(2-Aminoethyl)-6-chloro-benzo[b]thieno[2,3-c]pyridine-3-carboamido 10 i.v. 306±60 N-(2-Aminoethyl)-benzo[b]furano[2,3-c]pyridine-3-carboamido 10 i.v. 289±41 4-(Benzo[b]thieno[2,3-c]pyridine-3-carboamino)-butyric acid 10 i.v. 252±43 (3) Utilization of the Invention: Comparison tests for the antianxiety activity were performed on β-carbolin-3-ethyl ester (β-CCE) which is a typical compound of U.S. Patent 4,371,536, 6-chloro-1,2,3,4-tetrahydro-benzothieno[2,3-c]pyridine (C-1) which is a typical compound of U.S. Patent 3,651,068, both being comparative compounds in conventional techniques. N-ethyl-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine-3-carboamide·hydrochloride (A-1) and N-(2-aminoethyl)-benzothieno[2,3-c]pyridine-3-carboamide (A-2), both being typical compounds of this invention, were employed. Furthermore, the antianxiety activity of benzothieno[2,3-c]pyridine-3-carboxylic acid ethyl ester (A-3) as reference example was also measured. The test method was same as the above-described method of measuring antianxiety activity. The test results are shown in Table 19. Antianxiety Activity Medicament Dose (mg/kg) Route Shocked No. (mean value ± standard deviation) Control 100.0±14.3 (N=5) β-CCE 10 i.v. 98.9±27.0 (N=5) C-1 10 i.v. 112.3±36.6 (N=5) A-1 10 i.v. 201.0±27.0 (N=5) A-2 10 i.v. 299.0±29.0 (N=5) A-3 10 i.v. 125.3±28.9 (N=5) β-CCE 40 p.o. 82.9±20.0 (N=5) C-1 40 p.o. 104.3±28.6 (N=5) A-1 40 p.o. 384.3±60.0 (N=5) A-2 40 p.o. 326.3±46.0 (N=5) A-3 40 p.o. 117.1±25.7 (N=5) From the test results on the antianxiety activity shown in Table 19, N-ethyl-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine-3-carboamide·hydrochloride (A-1) and N-(2-aminoethyl)-benzothieno[2,3-c]pyridine-3-carboamide (A-2) of this invention are excellent in antianxiety activity as compared with known compounds, and clearly have sufficient antianxiety activity and learning improvement activity for practical utilization.

Claims: Pyridine derivates and 1,2,3,4-tetrahydropyridine derivates represented by general formulae (I) and (II), respectively, or salts thereof: wherein A is a sulfur atom or an oxygen atom; R 1 is a methoxy, an ethoxy, a propyloxy, a hexyloxy or a benzyloxy group; an amino group, a hydrogen atom bonded to the nitrogen atom of this group may be substituted, wherein the substituent is a C 1-6 -alkyl group, a hydrogen atom bonded to a carbon atom thereof may be substituted by an amino group, a carboxy group or an ester group; a hydrazino group; or a 6- or 7-membered heterocyclic group having at least one N-atom which may be substituted by a C 1-6 -alkyl group, a phenyl group or a 5- to 7-membered heterocyclic group having an N-atom; with the proviso that in formula (I), R 1 is not an alkoxy group; R 2 and R 3 are a halogen atom, an alkyl group, an aryl group, an alkenyl group, an acyl group, or an arylcarbonyl group which have 1 to 20 carbon atoms and may be substituted by a halogen atom, an amino group, a nitro group, an alkoxy group having 1 to 6 carbon atoms or a phenyl group; and m and n are an integer of from 0 to 4, with the proviso that when m is 2 or more, said R 2 (s) may be the same or different and that when n is 2 or more, said R 3 (s) may be the same or different. Pyridine derivates and 1,2,3,4-tetrahydropyridine derivates and salts thereof as claimed in claim 1, wherein A is a sulfur atom. Pyridine derivates and 1,2,3,4-tetrahydropyridine derivates and salts thereof as claimed in claim 2, wherein R 1 is an amino group, a hydrogen atom bonded to the nitrogen atom of this group may be substituted, wherein the substituent is a C 1-6 -alkyl group, a hydrogen atom bonded to a carbon atom thereof may be substituted by an amino group, a carboxy group or an ester group. Pyridine derivates and 1,2,3,4-tetrahydropyridine derivates and salts thereof as claimed in claim 2, wherein R 1 is a 6- or 7-membered heterocyclic group having at least one nitrogen atom which may be substituted by a C 1-6 -alkyl group, a phenyl group or a 5- to 7-membered heterocyclic group having an N-atom. Pyridine derivates and 1,2,3,4-tetrahydropyridine derivates and salts thereof as claimed in claim 3, wherein m and n are O.

Inventors: KAWAKUBO HIROSHI, NAGATANI TADASHI, OKAZAKI KATSUYA, UEKI SHOWA, KAWAKUBO, HIROSHI, NAGATANI, TADASHI, OKAZAKI, KATSUYA, UEKI, SHOWA, KAWAKUBO, HIROSHI ASAHI KASEI KOGYO K. K., NAGATANI, TADASHI ASAHI KASEI KOGYO K. K., OKAZAKI, KATSUYA ASAHI KASEI KOGYO K. K.
Applicants: ASAHI CHEMICAL IND, ASAHI KASEI KABUSHIKI KAISHA
Application year: 1987
Main classification: C07D491
IPC codes: C07D491, C07D495