Dibenz [b,e] oxepin derivative and antiallergic and antiinflammatory agent

Abstract: Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.

Description: Background of the Invention Heretofore, it has been known that 11-unsubstituted, 11-hydroxy or 11-oxodibenz[b,e]oxepin derivative is used for antiinflammatory agents [J. Med. Chem., 21 , 633 - 639 (1978)]. Further, it is known that dibenz[b,e]oxepin derivative wherein substitutents Ra and Rb at 11-position have the following definitions, is employed in the treatment and control of allergic conditions (USP 4.282.365). Ra: H, CH, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, arylthio, NH 2 , NHCHO or imidazolyl; Rb: H or lower alkyl; or Ra and Rb taken together are = 0, = CH-Rc wherein Rc is H or aryl. Furthermore, it is known that 11-(4-methylpiperazino) dibenz[b,e]oxepin derivative has an antiasthmatic activity (USP 4.396.550 USP 4.465,835, EP-A-38564). It is also known that dibenz[b,e]oxepin derivative having the following formula: wherein Rd and Re are lower alkyl and Rf is lower alkyl or halogen, has an antiasthmatic activity (EP-A-85870). Dibenz[b,e]oxepin derivative having an antiallergic activity and having the following structural formula: wherein Rg and Rh are alkyl, r is 2 or 3 and Ri is alkyl or halogen is known (JP-A-227879/84). Dibenz[b,e]oxepin derivative having an antiallergic activity and having the following structural formula: wherein Rj is 4-alkylpiperazino, 3-quinuclidylamino or -Xa-(CH 2 ) s -NR ℓ R m wherein Xa is -NH-, -S- or -O-, s is 2 or 3 and R ℓ and R m are alkyl, and R k is CN, 5-tetrazolyl, CONH 2 or CO 2 R n wherein R n is H, alkyl or 1-(ethoxycarbonyloxy)ethyl is known (EP-A-130555). Doxepin having an antidepressant activity and having the following structural formula is known [Drugs, 13 . 161(1977)]. Dothiepin having an antidepressant activity and having the following structural formula is known [Arz.-Forsch., 13 1039 (1963); ibid., 14 100 (1964)]. It is also known that dibenz [b,e] oxepin derivatives having the formula : wherein : R is hydrogen or methyl ; R 1 is a lower alkyl, lower alkenyl or lower cycloalkyl ; X and Y are each hydrogen, lower alkyl, lower alkoxy, lower alkylthio, chloro, fluoro, trifluoromethyl, lower acyl or dialkylsulfonamido, have an antidepressent activity (GB 1,018,955). It is known that dibenz [b,e] oxepin derivatives of formula : wherein R 5 is a single bond or -CH=CH-, have an anti-asthmatic activity (EP 214779). As the compound having both an anti-allergic activity and an anti-inflammatory activity, steroids are known. It is always desired that a novel compound having an antiallergic activity and an antiinflammatory activity be developed. The present invention relates to a dibenz[b, e]oxepin derivative represented by the formula (I): wherein A represents a carboxyl, a straight or branched (C 1 -C 6 ) alkoxy carbonyl group, -CONHOH or -CONR 1 R 2 wherein R 1 and R 2 are the same or different and represent hydrogen atom or a straight or a branched (C 1 -C 6 ) alkyl Y represents -(CH 2 )-, -CHR 3 -(CH 2 ) m - wherein R 3 represents a straight or branched (C 1 -C 4 ) alkyl, and m is 1, 2, 3 or 4, which is the substituent at 2- or 3-position of the mother nucleus and the left side of the group Y is bound to benzene nucleus. X represents =N-, =CH-; n is o, 1, 2, 3 or 4; Z represents 4-methylpiperazino, 4-methylhomopiperazino, piperidino, pyrrolidino, thiomorpholino, morpholino or -NR 6 R 7 wherein R 6 and R 7 are the same or different and represent hydrogen atom or a straight or branched (C 1 -C 4 ) alkyl a ---- means double bond; and the pharmaceutically acceptable salts thereof. The present invention further pertains to pharmaceutical composition containing an effective amount of Compound (I) or a pharmaceutically acceptable salt thereof as an active ingredient, and a carrier or an excipient. The present compound (I) is useful for treatment of allergic conditions and inflammation diseases. DETAILED DESCRIPTION OF THE INVENTION In the definition of each group of formula (I), the lower alkyl group includes straight or branched chain alkyl groups having 1 to 6 carbon atoms, for example, methyl, ethyl, n-propyl, iso-propyl, n-butyl, etc. In the definition of the group A, lower alkyl moiety of lower alkoxymethyl group and lower alkoxycarbonyl group has the same meaning as previously defined. The lower alkoxymethyl group includes methoxymethyl, ethoxymethyl, n-propoxymethyl, isopropoxymethyl, etc. and the lower alkoxycarbonyl group includes methoxycarbonyl, ethoxycarbonyl, etc. In the definition of the group A, the lower alkyl moiety of lower alkanoyl group and lower alkanyoloxymethyl group has the same meaning as previously defined. The lower alkanoyl group includes formyl, acetyl, etc. and the lower alkanoyloxymethyl group includes formylocymmethyl, acetyloxymethyl. The pharmaceutically acceptable salt of compound (I) includes pharmaceutically acceptable acid addition salt, metal salt, ammonium salt, organic amine addition salt, amino acid addition salt, etc.. The pharmaceutically acceptable acid addition salt of compound (I) includes inorganic acid salts such as hydrochloride, sulfate, phosphate, etc., and organic acid salts such as acetate, maleate, fumarate, tartrate, citrate, etc.. The pharmaceutically acceptable metal salt includes alkalimetal salts such as sodium salt, potassium salt, etc., alkaline earch metal salts such as magnesium salt, calcium salt, etc., and aluminium salt, zinc salt, etc.. The pharmaceutically acceptable organic amine addition salt includes addition salt of morpholine and piperidine and the pharmaceutically acceptable amino acid addition salt includes addition salt of lysine, glysine, phenylalanine, etc.. Compound (I) is prepared by using a compound represented by the formula (II): wherein Y and A have the same meanings as previously defined or a compound represented by the formula (III): wherein Y and A have the same meanings as previously defined as the starting compound. Compound (II) is disclosed in J. Med. Chem., 19 . 941 (1976), ibid., 20 , 1499 (1977) and JP-A-21679/83. Compound (III) wherein -Y-A is -COOH is disclosed in JP-A-21679/83 and the other Compounds (III) can be prepared according to the method described in the publication though they do not occur in the publication. The process for preparing Compound (I) is explained, depending on the kind of the group X. Process A [Synthesis of Compound (I) wherein X is = CH- (Part 1)] The carboxy group of Compound (IIa) is protected according to the following reaction scheme. In the formula, Y has the same meaning as previously defined, and Compound (IIa) is included in Compound (II) (compounds with an alphabet suffix following formula number are likewise included in compounds with common formula no.) Compound (IIa) is reacted with 1 to 5 equivalents of thionyl chloride and 1 to 5 equivalents of 2-amino-2-methyl-1-propanol on the basis of Compound (IIa) in an inert solvent such as methylene chloride, if necessary in the presence of a base such as triethylamine at a temperature of from 0°C to room temperature for 1-24 hours to form Compound (IV). Compound (IV) can also be obtained by reacting Compound (IIa) with thionyl chloride in advance and then with 2-amino-2-methyl-1-propanol. Compound (IV) is reacted with 1-5 equivalents of thionyl chloride in an inert solvent such as methylene chloride, toluene and benzene at a temperature of from 0°C to room temperature for I - 24 hours to form Compound (V). Compounds (Ia) and (Ib) can be prepared from Compound (V) according to the following reaction scheme. In the formulae, Y, Z, and n have the same meanings as previously defined, R 8 is hydrogen or a lower alkyl group, R' 8 is a lower alkyl group and Hal is halogen. As used herein, the term lower alkyl has the same meaning as that of lower alkyl in each group of formula (I). Halogen includes chlorine, bromine and iodine. Compound (V) is reacted with I - 5 equivalents of Compound (VI) in an inert solvent such as tetrahydrofuran and diethyl ether under atmosphere of an inert gas such as nitrogen and argon to form Compound (VII). The reaction is carried out at a temperature of from 0°C to room temperature and is usually completed in I - 24 hours. Compound (VII) is reacted with I - 5 equivalents of thionyl chloride or phosphoryl chloride in an inert solvent such as methylene chloride in the presence of a base such as pyridine to form Compound (la). The reaction is carried out at a temperature of from 0°C to room temperature and is completed in I - 24 hours. Compound (la) is incubated in an alcohol containing water, such as aqueous methanol solution, in the presence of an appropriate acidic catalyst such as p-toluenesulfonic acid at a temperature of from room temperature to the boiling point of the solvent to form Compound (Ib) wherein R 8 is H. The reaction is completed in I - 24 hours. Compound (VII) is incubated in an alcohol R 8 'OH in the presence of an appropriate acidic catalyst such as p-toluenesulfonic acid at a temperature of from room temperature to the boiling point of the solvent to form Compound (Ib) wherein R 8 is a lower alkyl. The reaction is completed in I - 24 hours. Process B [Synthesis of Compound (I) wherein X is =CH- (Part 2)] The carboxy group of a compound represented by the formula (IIa) can be converted to a lower alkoxymethyl group or a trityloxymethyl group according to the following reaction scheme. In the formulae, Y has the same meaning as previously defined, R 9 is a lower alkyl group and R 9 ' is a trityl group or a lower alkyl group. The term lower alkyl has the same meaning as that of lower alkyl in each group in formula (I). Compound (IIa) is reduced with I - 5 equivalents of lithium aluminium hydride in tetrahydrofuran at a temperature of from 0°C to room temperature for I - 24 hours to form Compound (VIII). Compound (VIII) is reacted with I - 5 equivalents of trityl chloride in pyridine at a temperature of from room temperature to 100°C for I - 24 hours to form Compound (IX). Compound (IX) is oxidized with I - 5 equivalents of an appropriate oxidizing agent such as potassium permanganate and pyridinium chlorochromate in an inert solvent such as methylene chloride and acetone to form Compound (XI) wherein R 9 is trityl. The reaction is carried out at a temperature of from 0°C to the boiling point of the solvent and is completed in I - 24 hours. Compound (VIII) is incubated in an alcohol of R 9 OH in the presence of an appropriate acidic catalyst such as sulfuric acid at a temperature of from room temperature to the boiling point of the solvent to form Compound (X). The reaction is usually completed in I - 24 hours. Compound (X) is oxidized with I - 5 equivalents of an appropriate oxidizing agent such as Jones reagent in an inert solvent such as acetone to form Compound (XI) wherein R 9 ' is a lower alkyl. The reaction is carried out at a temperature of from 0°C to the boiling point of the solvent and is usually completed in I - 24 hours. The compounds represented by the formulae (Ic) and (Id) and if desired, the compound represented by the formula (le) can be synthesized from Compound (XI) according to the following reaction scheme. In the formulae. Y, Z, R 9 ', n and Hal have the same meanings as previously defined. Compound (XI) is reacted with Compound (VI) which is Grignard reagent according to the same manner as in the reaction step from Compound (V) to Compound (VII) in Process A to form Compound (XII). Compound (XII) is subjected to reaction according to the same manner as in the reaction step from Compound (VII) to Compound (la) in Process A to form Compound (Ic). Compound (Ic) is incubated in a solvent containing water such as aqueous dioxane in the presence of an appropriate acidic catalyst such as p-toluenesulfonic acid at a temperature of from room temperature to the boiling point of the solvent to form Compound (Id). The reaction is usually completed in I - 24 hours. Compound (Id) can also be obtained in one step by incubating Compound (XII) in a solvent containing water such as aqueous dioxane in the presence of an appropriate acidic catalyst such as sulfonic acid at a temperature of from room temperature to the boiling point of the solvent. The reaction is usually completed in I - 24 hours. If desired, Compound (Id) is oxidized with I - 5 equivalents of an appropriate oxidizing agent such as Jones reagent in an inert solvent such as acetone to form Compound (le). The reaction is carried out at a temperature of from 0°C to the boiling point of the solvent and is usually completed in I - 24 hours. Process C [Synthesis of Compound (I) wherein X is =CH- (Part 3)]. In the formulae, Y, Z, and n have the same meanings as previously defined. A' represents the groups falling within the definition of A but lower alkanoyl group. Compound (IIb) is reacted with I - 5 equivalents of Compound (XIII) in an inert solvent such as tetrahydrofuran under atmosphere of an inert gas such as nitrogen and argon at a temperature of from 0°C to room temperature for I - 24 hours to form Compound (I f ). Compound (XIII) which is ylide, can be prepared according to the method described in C.A. 63 16366a (1965). In the formulae, Hal, n and Z have the same meanings as previously defined and q is I or 2. Compound (XIV) is reacted with an equivalent of triphenylphosphine in toluene at reflux of the solvent for I - 24 hours to form Compound (XV). Compound (XV) is reacted with I - 5 equivalents of HZ in ethanol at reflux of the solvent for I - 24 hours and excess HZ is distilled away under reduced pressure. After the addition of I - 5 equivalents of HHal on the basis of Compound (XV), the mixture is incubated at a temperature of from 0°C to the boiling point of the solvent for I - 24 hours to form Compound (XVI) which is Wittig reagent. Compound (XVI) is treated with I - 2 equivalents of an appropriate base such as n-butyl lithium in an inert solvent such as tetrahydrofuran under atmosphere of an inert gas such as nitrogen and argon to form ylide (XIII). The reaction is carried out at -78°C ~ room temperature and is usually completed in I - 24 hours. Process D [Synthesis of Compound (I) wherein X is =CH- (Part 4)] In the formulae, Y, Z and A have the same meanings as previously defined. The process is known as Prince reaction [New Experimental Chemical Course (Maruzen), Vol. 14, Synthesis and Reaction of Organic Compound III, page 1375 (1977)]. Compound (III), I to 5 equivalents of formaldehyde and I to 5 equivalents of HZ are subjected to reaction in an inert solvent such as tetrachloroethane in the presence of an acid or reaction in an acid as such serving as a solvent under atmosphere of an inert gas such as nitrogen and argon to yield Compound (Ig). The formaldehyde or polymerized formaldehyde includes p-formaldehyde, trioxane, etc. The acid includes acetic acid, trichloroacetic acid, trifluoroacetic acid, etc. The reaction is carried out at a temperature of from room temperature to the boiling point of the solvent and is completed in I - 24 hours. Compound (III) which is the starting material can be prepared according to the process described in JP-A-21679/83, as shown below. That is, Compound (IIb), I to 5 equivalents of methyltriphenylphosphonium bromide and I to 5 equivalents of n-butyl lithium on the basis of Compound (IIb) are subjected to reaction in an inert solvent at from -78°C to room temperature for I to 5 hours to yield ylide (XVII) which is reacted with an equivalents of Compound (IIb) in an inert solvent at from -78°C to room temperature under atmosphere of an inert gas for I to 24 hours to yield Compound (IIIa). The inert gas includes nitrogen, argon, etc. and the inert solvent includes tetrahydrofuran, etc. The group A' in Compound (IIIa) can easily be converted to a lower alkanoyl group and therefore, Compound (III) can easily be prepared. Process E [Synthesis of Compound (I) wherein X is = N-] Compound (IIb) and I to 10 equivalents of Compound (XVIII) are subjected to reaction in an inert solvent such as benzene in the presence of I to 10 equivalents of titanium tetrachloride at from 0°C to the boiling point of the solvent under atmosphere of an inert gas such as nitrogen and argon for I to 48 hours to yield Compound (Ih). Table 1 shows examples of Compound (I) or pharmaceutically acceptable salts thereof and Table 2 shows the structural formula thereof. Compound Retention time in HPLC (Minutes) Eluent Cis Trans 3 9.93 7.46 B 5 11.10 8.40 B 7 10.50 8.00 B 9 11.20 8.93 B 26 10.77 - B 28 10.65 - B Instrument: SHIMAZU LC-3A Column Yamamurakagaku YMC A-312 A 0.01M PIC B-8 in 54.3% MeOH B 0.01M PIC B-9 in 61,3% MeOH C 0.01M PIC B-8 in 66.0% MeOH *PIC : PIC reagent (Produced by Water Associates) Pressure : 85 - 95 kg/cm 2 Temperature : room temperature Compound (I) has both an antiallergic activity and antiinflammatory activity. Among Compound (I), the compound represented by the formula (I') has strong antiallergic activity and the compound represented by the formula (II') has strong antiinflammatory activity. In the formula, X, n and Z are as previously defined. -Y'-A' is -Y-A when X is = CH and is -Y-A which is bound at 2 position of the mother nucleus when X is = N-, and Y and A are as previously defined. In the formula, n and Z are as previously defined: Y' is -CH 2 - or -CHR 3 - substituted at 2 or 3 position of the mother nucleus wherein R 3 is a lower alkyl; A - is, a a carboxyl, a lower alkoxycarbonyl, a -CONR 1 R 2 wherein R 1 and R 2 are the same or different and are hydrogen atom or -CONHOH. the preferred compounds according to the invention are the compounds of formula (I) as above defined wherein A is a member selected from the group consisting of lower alkoxycarbonyl, (-CONR 1 R 2 ), carboxyl ; Y is bound at 2-position of the mother nucleus ; X is member selected from the group consisting of = N-and =CH- : n is 1 or 2 ; and Z is a member selected from the group consisting of dimethylamino. diethylamino, methylamino, amino, morpholino and thiomorpholino. Of those particular compounds, those of formula (I) wherein Y is a member selected from the group and m is 1 or 2, are preferred and more particulary these of formula (I) wherein X is = CH- and A is a carboxyl. The most preferred compounds are those of formula (I) wherein -Y-A is a member selected from the group consisting of carboxymethyl, X is = CH-, n is 2 and Z is a member selected from the group consisting of dimethylamino, diethylamino methylamino, amino, morpholino and thiomorpholino. The antiallergic activity and antiinflammatory activity of Compound (I) are described below: Test for antiallergic activity: Antiallergic activity was investigated by a homologous PCA (passive cutaneous anaphlaxis) of rats for 48 hours, where Wistar male rats having body weights of 180 to 220 g were used for sampling of antiserum and Wistar male rats having body weights of 120 140 g were used for the PCA test. A) Preparation of anti EWA rat serum Anti-egg white albumin (EWA) rat serum was prepared according to Stotland and Share's method [Canad. J. Physiol. Pharmacol. 52 . 1114 (1974)]. That is, 1 mg of EWA was mixed with 20 mg of aluminum hydroxide get and 0.5 ml of mixed vaccine of pertussis, diphtheria and tetanus, and the mixture was subcutaneously administered in four portions into rat's footpad. After 14 days, blood was sampled from the carotid artery, and the serum was separated from the sampled blood, and preserved under freezing at -80°C. The potency of the antiserum in the homologous PCA for 48 hours was 1 : 32. B) Homologous PCA test of rats for 48 hours Groups each consisting of 3 rats were used, and 0.05 ml of anti-EWA rat serum diluted with a physiological saline solution to 8 times as much was incutaneously injected each at two positions of depilated back to make the animals passively sensitised. After 47 hours, the compound of the present invention, or its solution (physiological saline solution or CMC solution) was orally administered. One hour thereafter, 0.5 ml/100 g of 1% Evan's blue physiological saline solution containing 2 mg of the antigen EWA was administered into the tail vein, and 30 minutes thereafter, the animals were sacrificed by exsanguination. Then, the skins were stripped and the amount of leaked pigment at the blue-dyed parts was measured according to the Katayama et at method [Microbiol. Immunol. 22 , 89 (1978)]. That is, the blue-dyed parts were cut out by scissors, and placed in test tubes containing I ml of IN KOH and incubated at 37°C for 24 hours. Then, 9 ml of a mixture of 0.6N phosphoric acid and acetone (5 :13) was added thereto, and the mixture was shaked and centrifuged at 2,500 rpm for 10 minutes. Absorbancy of the supernatant at 620 µm was measured, and the amount of leaked pigment was quantitatively determined by the calibration curve prepared in advance. An average of measurements at the two position was made a value for one zooid, and inhibition rate for the individual zooid was calculated by the following formula: Cases where, the inhibition rate is 50% or higher, were regarded as positive PCA inhibition activity, and the minimum administered dosage, where a positive case was observed in at least one of three zooids was regarded as minimum effective dosage (MED). The results are shown in Table 5. Acute toxicity test: Groups each consisting of 3 dd, male mice having body weights of 20 ± 1 g were used, and the compound of the present invention was administered orally (po: 300 mg/kg) or intraperitoneally (ip: 100 mg/kg). Mortality 7 days after the administration was observed to obtain MLD (minimum lethal dosage). The results are shown in Table 5. Antiinflammatory activity test: Antiinflammatory activity was examined according to Rat carrageenin paw edema [J. Pathol. 104 . 15-29 (1971)]. Groups each consisting of three Wistar male rats weighing 150 g were used. The test compound was suspended in 0.3% aqueous CMC solution and the suspension was given orally. Sixty minutes later, 0.1 ml of 0.1% carrageenin solution was subcutaneously injected in a hind paw to form carageenin paw edema. The volume of paw was measured before the administration and 3 hours after the administration of carageenin with plethysmometer. The ratio of the volume 3 hours after the administration to that before the administration of carageenin was calculated and each ratio is compared with the ratio of control group (0.3% CMC solution was administered) to give the edema inhibiting percentage. The results are shown in Table 6. Compound No. Carrageenin paw edema inhibiting percentage (%) (Average value in one group of 3 rats. 100 mg kg oral administration) 13 51.6 15 50.2 17 38.7 18 63.1 21 46.0 23 24.1 As is evidenced in Tables 5 and 6. Compound (I) and pharmaceutically acceptable salt thereof have PCA inhibiting activity and or carageenin paw edema inhibiting activity. PCA inhibiting activity is believed to be on the basis of an activity inhibiting liberation of chemical mediator such as histamine from fat skin cell. Therefore. Compound (I) and pharmaceutically acceptable salts thereof are believed to be useful for treating an allergic disease such as bronchus asthma which is caused by trachea contracting activity of chemical mediator such as histamine. On the other hand, carageenin paw edema inhibiting activity is believed to be on the basis of prostaglandin biosynthesis inhibiting activity. Thus. Compound (I) and pharmaceutically acceptable salts thereof are believed to be useful for treating an acute inflammation and rheumatism which are ascribed to excessive prostaglandin. Compound (I) includes a compound having both antiallergic and antiinflammatory activities described above which is useful for the treatment of allergic diseases accompanied by inflammation. In view of the pharmacological activity of Compound (I). Compound (I) can be used in various medicament forms for the administration purposes. The present medicament composition can be prepared by uniformly mixing an effective amount of a free Compound (I) or a pharmaceutically acceptable salt thereof as an active component with a pharmaceutically acceptable carrier or excipient. The carrier can take a wide range of forms in accordance with a desirable medicament form for the administration. These medicament compositions are desirably in a unit dosage form suitable for the oral administration or injection administration. In the preparation of a composition in the oral dosage form, any useful, pharmaceutically acceptable carrier can be used. For example, an oral liquid preparation such as a suspended medicament or syrup medicament can be prepared using water; sugars such as sucrose, sorbitol, fructose, etc.; glycols such as polyethylene glycc!. propylene glycol, etc.; oils such as sesame oil, olive oil, soybean oil, etc.; antiseptics such as alkyl parahydroxybenzoate, etc.; and flavors such as strawberry flavor, peppermint, etc. Powder, pills, capsules and tablets can be prepared using an excipient such as lactose, glucose, sucrose. mannitol, etc.; a disintegrator such as starch, sodium alginate, etc.; a lubricant such as magnesium stearate, talc, etc.; a binder such as polyvinyl alcohol, hydroxypropylcellulose, galatin, etc.; a surfactant such as fatty acid esters: and a plasticizer such as glycerine, etc. Tablets and capsules are the most useful oral unit dosage forms because of easy administration. To prepare tablets and capsules. solid carriers for medicament are used. Injection solution can be prepared using a carrier consisting of a salt solution, a glucose solution or a mixture of the salt solution and the glucose solution. The effective dosage of Compound (I) is I to 20 mg/kg/day for a human being, and number of administration is 3 to 4 per day. Examples and Reference Examples are given below: Reference example I (Raw material I) Methyl II-oxo-6,II-dihydrodibenz[b.e] oxepin-2-carboxylate In this example, 348.9 g of sodium salt of methyl p-hydroxybenzoate, 402.4 g of phthalide and 200 g of sodium chloride are mixed with one another and stirred at 150°C for 6 hours. After completion of the reaction, the mixture is cooled until the temperature is brought back to room temperature, 4 t of aqueous 10 % acetic acid solution is added thereto and the mixture is allowed to stand at room temperature overnight. After stirring the mixture at room temperature for 3 hours, deposited crystals are separated by filtration, and 6 t of water is added thereto. After stirring the mixture at room temperature for 30 minutes, the deposited crystals are separated by filtration. After the addition of 3 t of toluene to the crystals, the mixture is stirred at room temperature for one hour. The crystals are separated by filtration and dried over heating under reduced pressure to yield 393.9 g of 2-(4-methoxycarbonylphenoxy) methyl benzoic acid. IR (KBr disk): 3400, 1700, 1610, 1260, 1235 cm -1 The thus obtained 2-(4-methoxycarbonylphenoxy) methyl benzoic acid (392.7 g) is suspended in 5.0 l of methylene chloride and 266.0 g of trifluoroacetic anhydride is added thereto. After stirring the mixture at room temperature for one hour. 19.4 g of boron trifluoride-ethylether complex is added thereto and the mixture is stirred at room temperature for two hours. The reaction solution is poured into ice water. After an organic solvent layer is separated from the mixture, the organic layer is washed with diluted aqueous sodium hydroxide solution and water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 335.3 g of methyl II-oxo-6,11-dihydrodibenz[b.e]oxepin-2-carboxylate as a white crystal. Melting point and elementary analysis are shown in Table 7. IR (KBr disk): 1710, 1650, 1610, 1250, 1010 cm -1 NMR (CDCl 3 , δ, ppm): 3.84(s, 3H), 5.14(s, 2H), 6.87-8.93(m, 7H) Reference examples 2 - 5 (Raw material 2) II-Oxo-6,II-dihydrodibenz[b,e]oxepin-2-acetic acid (Raw material 3) II-Oxo-6,II-dihydrodibenz[b,e]oxepin-3-acetic acid (Raw material 4) 2-(II-Oxo-6,II-dihydrodibenz[b,e]oxepin-2-yl)-propionic acid (Raw material 5) 3-(II-Oxo-6,II-dihydrodibenz[b,e]oxepin-2-yl)-propionic acid Raw materials 2 - 5 are produced by respectively substituting p-hydroxyphenyl acetic acid, m-hydroxyphenyl acetic acid, 2-(p-hydroxyphenyl)-propionic acid and 3-(p-hydroxyphenyl)-propionic acid for methyl p-hydroxybenzoate in Reference example I. Melting points and elementary analyses thereof are shown in Table 7. Reference example 6 (Raw material 6) Methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-2-carboxylate In 100 ml of tetrahydrofuran is suspended 25 g of methyltriphenylphosphonium bromide and 40 ml of 1.6 N-n-butyl lithium hexane solution is dropwise added thereto under a nitrogen atmosphere and ice-cooling. After stirring the mixture under ice-cooling for 30 minutes, a solution obtained by dissolving 15 g of methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-carboxylate in 250 ml of tetrahydrofuran is dropwise added thereto and the mixture is stirred at room temperature for two hours. The solvent is distilled away under reduced pressure and the residue is purified by column chromatography on silica gel (eluent: hexane :ethyl acetate = 3 :l) to obtain 3.7 g of the desired product as a colorless oily matter. NMR (CDCl 3 , δ, ppm): 3.83(s, 3H), 5.15(s, 2H), 5.29 (s, IH), 5.74(s, IH), 6.69-8.22(m, 7H) Melting point and elementary analysis are shown in Table 7. Reference example 7 (Raw material 7) Methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-2-acetate The desired product is obtained by substituting II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-acetic acid for methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-carboxylate in Reference example 6. Colorless oily matter NMR (CDCl 3 , δ, ppm): 3.48(s, 2H), 3.61(s, 3H), 5.05 (s, 2H), 5.20(s, IH), 5.62(s, IH), 6.59-7.43 (m, 7H) IR (neat, cm -1 ): 2950, 1740, 1615, 1490, 1010 Melting point and elementary analysis are shown in Table 7. Reference example 8 (Raw material 8) II-Methylene-6,II-dihydrodibenz[b,e]oxepin-2-acetic acid To a mixed solvent of 200 ml of methanol and 50 ml of 2N-aqueous sodium hydroxide solution is added 2.9 g of methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-2-acetate (raw material 7, Reference example 7) and the mixture is heated at reflux for two hours. After allowing the mixture to stand for cooling, the mixture is concentrated under reduced pressure, and the pH of the mixture is adjusted to 1.0 with aqueous 4N-hydrochloric acid solution. The mixture is extracted with 500 ml of ethyl acetate, then the organic layer is washed with aqueous IN-hydrochloric acid solution and saturated aqueous sodium chloride solution in order and dried over anhydrous sodium sulfate The solvent is distilled away under reduced pressure and the resultant crude product is crystallized from hexane to obtain 2.7 g of the desired product as a white solid. NMR (DMSO-d 6 + D 2 O, δ, ppm): 3.45(s, 2H), 5.02(s, 2H), 5.16(s, IH), 5.60(s, IH), 6.45-7.44(m, 7H) Melting point and elementary analysis are shown in Table 7. Reference example 9 (Raw material 9) Methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-3-acetate The desired product is obtained by substituting II-oxo-6,II-dihydrodibenz[b,e]oxepin-3-acetic acid for methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-carboxylate in Reference example 6. Reference example 10 (Raw material 10) II-Methylene-6,II-dihydrodibenz[b,e]oxepin-3-acetic acid The desired product is obtained by substituting methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-3-acetate for methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-2-acetate in Reference example 8. Reference example 11 (Reagent I) (3-Dimethylaminopropyl)-triphenylphosphonium bromide hydrobromide In this example, 350.0 g of triphenylphosphine and 270.0 g of dibromopropane are suspended in 700 ml of toluene and the suspension is heated at reflux for 25 hours. After allowing the suspension to stand for cooling, the formed product is separated by filtration and washed with 2 l of toluene to obtain 550.0 g of (3bromopropyl)-triphenylphosphonium bromide hydrobromide having m.p. 233-234°C. Then, 100.0 g of (3-bromopropyl)-triphenylphosphonium bromide hydrobromide is suspended in 500 ml of ethanol and 300 ml of 50 % aqueous dimethylamine solution is added thereto. After heating the mixture at reflux for 10 minutes, the mixture is allowed to stand for cooling. The solvent is distilled away under reduced pressure and the resultant crude product is recrystallized from ethanol to obtain 64.0 g of the desired product having the physicochemical properties as identified in Table 8. Reference examples 12 - 14 (Reagent 2) (3-Diethylaminopropyl)-triphenylphosphonium bromide hydrobromide · 1/3 hydrate (Reagent 3) (4-Dimethylaminobutyl)-triphenylphosphonium bromide hydrobromide (Reagent 4) (3-Pyrrolidinopropyl)-triphenylphosphonium bromide hydrobromide · 1/2 hydrate The above-captioned compounds are prepared according to the same manner as in Reference example II and the physicochemical properties are shown in Table 8. Example 1 II-(3-Dimethylaminopropylidene)-6,II-dihydrodibenz[b,e]oxepin-2-acetic acid (Compound 3) In this Example, 2.2 g of II-(3-dimethylaminopropylidene)-2-(2-hydroxyethyl-6,II-dihydrodibenz[b,e]-oxpein is dissolved in 100 ml of acetone. The Jones reagent is added to the solution until the reaction solution shows an orange color and the mixture is stirred at room temperature for one hour. Sodium bicarbonate is added thereto and an inorganic substance is removed by filtration. The solvent of the filtrate is distilled away under reduced pressure to obtain the desired product. The physicochemical properties of the product coincide with those of the product obtained in Example 17. Example 2 Methyl II-(3-dimethylaminopropylidene)-6,II-dihydrodibenz[b,e]oxepin-2-acetate (Compound 1) In this example, 48 g of (3-dimethylaminopropyl) - triphenylphosphonium bromide hydrobromide is suspended in 200 ml of tetrahydrofuran under a nitrogen atmosphere and 80 ml of I.6N-n-butyl lithium hexane solution is added thereto under ice-cooling. The mixture is stirred under ice-cooling for one hour. A solution obtained by dissolving 5.0 g of II-oxo-6,II-dihydrodibenz [b,e]oxepin-2-acetic acid in 120 ml of tetrahydrofuran is dropwise added under ice-cooling. After stirring the mixture at room temperature for two hours, the solvent is distilled away under reduced pressure. Then, 200 ml of water is added to the residue and the mixture is washed with 200 ml of diethyl ether. The pH of the mixture is adjusted to I with aqueous 4N-hydrochloric acid solution and the mixture is washed with diethyl ether. Then, aqueous 10N-sodium hydroxide solution is added thereto to adjust the pH of the mixture to 7 and the solvent is distilled away under reduced pressure. The resultant residue is dissolved in 400 ml of methanol and 5 g of p-toluene sulfonic acid is added thereto. After heating the mixture at reflux for two hours, the solvent is distilled away under reduced pressure. The residue is extracted with 300 ml of ethyl acetate, and the organic layer is washed with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution in order and dried over anhydrous sodium sulfate. The solvent is distilled away under reduced pressure and the resultant residue is purified by column chromatography on silica gel (eluent: hexane : ethyl acetate : triethylamine = 10 : 10 : I) to obtain 4.0 g of the desired product as a colorless oily matter. Cis form NMR (CDCl 3 , δ, ppm): 2.06-2.67(m, 4H). 2.16(s, 6H), 3.46(s, 2H). 3.58(s, 3H). 5.08(bs, 2H). 5.69 (I, IH, J = 7Hz). 6.53-7.30(m. 7H) Trans form NMR (CDCI 3 , δ, ppm): 2.06-2.67(m, 4H). 2.16(s, 6H). 3.46(s, 2H), 3.58(s, 3H). 5.08(bs, 2H). 6.00 (t, IH, J = 7Hz). 6.53-7.30(m, 7H) Example 3 Methyl II-(4-dimethylaminobutylidene)-6,II-dihydrodibenz[b,e]oxepin-2.acetate (Compound 4) The desired product is obtained by substituting (4-dimethylaminobutyl)-triphenylphosphonium bromide hydrobromide for (3-dimethylaminopropyl)-triphenylphosphonium bromide hydrobromide in Example 2. Example 4 Methyl II-(3-pyrrolidinopropylidene)-6-II-dihydrodibenz[b,e]oxepin-2-acetate (Compound 6) The desired product is obtained by substituting (3-pyrrolidinopropyl)-triphenylphosphonium bromide hydrobromide·1/2 hydrate for (3-dimethylaminopropyl)-triphenylphosphonium bromide hydrobromide in Example 2. Example 5 Methyl II-(3-dimethylaminopropylidone)-6,II-dihydrodibenz[b,e]oxepin-3-acetate (Compound 10) The desired product is obtained by substituting II-oxo-6,II-dihydrodibenz[b,e]oxepin-3-acetic acid for II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-acetic acid in Example 6. Example 6 Methyl II-(2-dimethylaminoethyl)imino-6,II-dihydrodibenz[b,e]oxepin-2-acetate (Compound 12) In this example, 22.0 g of methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-acetate and 68.7 g of N.N-dimethylethylenediamine are dissolved in 700 ml of dried benzene. To the solution is dropwise added a solution of 17.2 ml of titanium tetrachloride in 40 ml of dried benzene and the mixture is stirred at room temperature overnight. A saturated aqueous sodium bicarbonate solution is added thereto. After removing an insoluble solid by filtration, the filtrate is extracted with 500 ml of ethylacetate, and the organic layer is washed with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution in order, and dried over anhydrous sodium sulfate. The solvent is distilled away under reduced pressure and the residue is purified by column chromatography on silica gel with ethylacetate triethylamine (10 1) as an eluent to obtain 13.8 g of the desired product as a colorless oily matter. NMR (CDCl 3 , δ, ppm): 2.14(s, 6H). 2.63(t, 2H, J=6.9Hz), 3.51(s, 2H). 3.58(s, 3H), 3.38-3.80 (m, 2H). 5.04(bs, 2H). 6.56-7.60 (m, 7H) IR (neat. cm -1 ): 2950, 1740, 1630, 1305, 1015 Mass spectrum (m z): 352 (M - ) Example 7 Methyl II-(2-diethylaminoethyl)imino-6,II-dihydrodibenz[b,e]oxepin-2-acetate (Compound 14) The desired product is obtained by substituting N.N-diethylethylenediamine for N.N-dimethyiethylenediamine in Example 6 a colorless oily matter. Mass spectrum (m z): 380 (M - ) for C 23 H 28 O 3 N 2 Example 8 Methyl II-(3-dimethylaminopropyl)imino-6,II-dihydrodibenz[b,e]oxepin-2-acetate (Compound 16) The desired product is obtained by substituting N,N-dimethylpropylenediamine for N.N-dimethylethylenediamine in Example 6 as a colorless oily matter. Mass spectrum (m z): 366 (M - ) for C 22 H 26 O 3 N 2 Example 9 Methyl 2-[II-(2-dimethylaminoethyl)imino-6,II-dihydrodibenz[b,e]oxepin-2-yl]-propionate (Compound 18) The desired product is obtained by substituting methyl 2-(II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-yl)-propionate acid for methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-acetate in Example 6 as a colorless oily matter. Mass spectrum (m z): 366 (M - ) for C 22 H 26 O 3 N 2 Example 10 Methyl II-(2-dimethylaminoethyl)imino-6,II-dihydrodibenz[b,e]oxepin-3-acetate (Compound 20) The desired product is obtained by substituting methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-3-acetate for methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-acetate in Example 6 as a colorless oily matter. Mass spectrum (m/z): 352 (M - ) for C 21 H 24 O 3 N 2 Example 11 Methyl II-(3-dimethylaminopropyl)imino-6,II-dihydrodibenz[b,e]oxepin-3-acetate (Compound 22) The desired product is obtained by substituting methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-3-acetate for methyl II-oxo-6,II-dihydrodibenz[b,e]oxepin-2-acetate in Example 8 as a colorless oily matter. Mass spectrum (m/z): 366 (M-) for C 22 H 26 O 3 N 2 Reference Exemple 12 Methyl-II-[2-(4-methylpiperazino)ethylidene]-6,II-dihydrodibenz[b,e]oxepin-2-carboxylate (Compound 10) In this example, 1,5 ml of 4-methylpiperazine and 0.37 g of p-formaldehyde are dissolved in 100 ml of tetrachloroethane. To the solution is dropwise added 5 ml of trifluoroacetic acid. After stirring the mixture at 60°C for 2 hours, a solution obtained by dissolving 1.8 g of methyl II-methylene-6,II-dihydrodibenz[b,e]-oxepin-2-carboxylate in 30 ml of tetrachloroethane is dropwise added thereto and the mixture is stirred at 90°C for 3 hours. The mixture is concentrated to dryness under reduced pressure and aqueous 4N-hydrochloric acid solution is added to the residue to adjust the pH to 1. After washing the solution with diethylether, aqueous 10N-sodium hydroxide solution is added thereto to adjust the pH to 13. The mixture is extracted with 200 ml of methylene chloride, washed with saturated aqueous solution chloride solution and dried over anhydrous sodium sulfate. The solvent is distilled away under reduced pressure. The residue is purified by column chromatography on silica gel (eluent: hexane: ethyl acetate : triethylamine = 5 : 5 :1) to obtain 2.2 g of the desired product as a colorless oily matter. Cis form NMR (CDCI 3 , δ . ppm): 2.24(s, 3H), 2.45(s, 8H), 2.94-3.32(m, 2H), 3.84(s, 3H) 5.22(bs, 2H), 5.85(t, IH, J = 6.8Hz), 6.66-8.07(m, 7H) Mass spectrum (m/z): 378 (M - ) Trans form NMR (CDCI 3 , δ, ppm): 2.24(s, 3H). 2.45(s, 8H), 2.94-3.32(m, 2H). 3.84(s, 3H), 5.22(bs, 2H). 6.22(t, IH, J = 6.8Hz) Mass spectrum (m/z): 378 (M - ) Example 12 Methyl II-[2-(4-methylpiperazino)ethylidene]-6,II-dihydrodibenz[b,e]oxepin-2-acetate (Compound 8) The desired product is obtained by substituting methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-2-acetate for methyl II-methylene-6,II-dihydrodibenz[b,e]oxepin-2-carboxylate in Reference example 12 Example 13 II-(3-Dimethylaminopropylidene)-6,II-dihydrodibenz[b,e]oxepin-2-acetic acid (Compound 3) The product is obtained by hydrolysis of methyl 11-(3-dimethylaminopropylidene)-6.11-dihydrodibenz-[b,e]oxepin acetate in presence of sodium hydroxide. Cis form white crystal Melting point: 118 - 120°C (Isopropanol) NMR (DMSO-d 6 , δ, ppm): 2.16(s, 6H), 2.30-2.60(m, 4H), 4.04(s, 2H), 5.15(bs, 2H). 5.69(1, IH. J = 7Hz). 6.73-7.40(m, 7H) IR (KBr disk, cm -1 ): 3400. 1580. 1225. 1005 Mass spectrum (m z): 337 (M - ) Elementary analysis (%): as C 2 ·H 23 O 3 N · monohydrate C H N Found 70.77 7.36 3.74 Calculated 70.96 7.09 3.94 Trans form white crystal Melting point: 158 - 160°C (Acetonitrile) NMR (DMS o -d 6 , δ, ppm): 2.05(s, 6H), 2.30-2.60(m, 4H), 4.04(s, 2H), 5.15(bs, 2H), 6.06(t, 1H. J = 7Hz). 6.73-7.40(m, 7H) IR (neat. cm -1 ): 3380. 1575. 1220. 1005 Mass spectrum (m/z): 337 (M°) Elementary analysis (%): as C 21 H 23 O 3 N · monohydrate C H N Found 71.06 6.66 3.92 Calculated 70.96 7.09 3.94 Examples 14-16 11-(4-Dimethylaminobutylidene)-6.11-dihydrodibenz[b.e]oxepin 2-acetic acid (Compound 5) 11-(3-Pyrrolidinopropylidene)-6.11-dihydrodibenz[b.e]oxepin-2-acetic acid (Compound 7) 11-[2-(4-Methylpiperazino)ethylidene)-6.11-dihydrodibenz[b.e]oxepin-2-acetic acid (Compound 9) These products are obtained by hydrolysis in the same manner as in Example 13. The physicochemical properties are shown in Table 9. Example 18 11-(2-Dimethylaminoethyl)imino-6.11-dihydrodibenz [b.e]oxepin-2-acetic acid (Compound 13) The desired product is obtained as a 8 : 92 mixture of syn-form and anti-form by hydrolysis in the same manner as in Example 12. White crystal Melting point 174 - 176°C (as 1 2 hydrate) NMR (DMSO-d 6 . δ , ppm): 2.07(s, 6H). 2.30-2.80(m, 4H). 3.47(s, 2H). 4.90-5.30(broad, 2H). 6.74-7.62 (m, 7H) IR (K3r disk, cm -1 ): 3330. 1573. 1370. 1010 Elementary analysis (%): as C 20 H 22 N 2 O 3 ·12 hydrate C H N Found 69.47 5.77 8.06 Calculated 69.14 6.67 8.06 Examples 19-23 11-(3-Dimethylaminopropyl)imino-6.11-dihydrodibenz [b.e]oxepin-2-acetic acid (Compound 15) 11-[3-(2-Dimethylaminopropyl)imino-6.11-dihydrodibenz [b.e]oxepin-2-acetic acid (Compound 17) 2-11-(2-Dimethylaminoethyl)imino-6.11-dihydrodibenz [b.e]oxepin-2-yl]-propionic acid (Compound 19) 11-(2-Dimethylaminoethyl)imino-6.11-dihydrodibenz [b.e]oxepin-3-acetic acid (Compound 21) 11-(3-Dimethylaminopropyl)imino-6.11-dihydrodibenz [b.e]oxepin-3-acetic acid (Compound 23) The desired compounds are obtained by hydrolysis in the same manner as in Exampie 22. The physicochemical properties are shown in Table 10. reference example 24 1 2 Furamarate · 1 5 hydrate of Compound C (Compound C') In this example, 3.95 g of 11-(3-dimethylaminopropylidene)-6.11-dihydrobenz[b,e]oxepin-2-carboxylic acid (Compound 3) is dissolved in 100 ml of acetone and 1.42 g of fumaric acid is added thereto. The mixture is stirred at room temperature. The deposited crystals are recovered by filtration and recrystallized from isopropanol to obtain 4.15 g of the 1/2 fumarate 1/5 hydrate of the starting compound as a white solid. Melting point: 253-254°c Isomer purity: Trans form 99% (measured by HPLC) Elementary analysis (%): as C 20 H 21 NO 3 · 1/2C 4 H 4 O 4 · 1/5H 2 O C H N Found 68.74 6.35 3.61 Calculated 68.63 6.13 3.64 Examples 25-26 The products are identified in Table 11, and then physico-chemical properties are shown in Table 12. Reference Example 17 Monosodium salt · monohydrate of Compound 35 (Compound 35') In this example, 1.00 g of 11-(2-diethylaminoethyl)imino-6.11-dihydrodibenz[b.e]oxepin-2-carboxylic acid (Compound 35) is dissolved in 100 ml of methanol and 5.5 ml of 28% sodium methoxide methanol solution is added thereto. After stirring the mixture for one hour, the solvent is distilled away under reduced pressure. The residue is triturated by adding isopropylether and is recovered by filtration to obtain 0.98 g of the monosodium sal; monohydrate of the starting compound as a white solid. Melting point: vague owing to absorption of moisture Ratio to isomer: Syn : Anti = 1 : 1 Elementary analysis: as C 2 ·H 25 O 4 N 2 Na · H 2 O C H N Found 64.23 6.62 7.01 Calculated 64.27 6.68 7.14 Example 27 The product is identified in Table 13, and its physicochemical properties are shown in Table 14. Compound No. 19' Sodium salt · monohydrate of Compound 19 (Anti form 99%) Example 28 Powder A powder comprising the following components is prepared in conventional manner. Trans-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic 30 mg acid · monofumarate · 3/2 hydrate (Compound 3'): Lactose: 270 mg Example 29 Syrup A syrup comprising the following components is prepared in a conventional manner. 11-(2-dimethylaminoethyl)imino-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid (Compound 13): 300 mg Purified sucrose: 40 g Metryl p-oxybenzoate: 40 mg Propyl p-oxybenzoate 10 mg Strawberry flavor: 0.1 cc Water is added to the above components until the total valume becomes 100 cc Example 30 Methyl II-(3-methylaminopropylidene)-6,II-dihydrodibenz[b.e]oxepin-2-acetate (Compound 25) The desired product is obtained by substituting (3-methylaminopropyl)-triphenylphosphonium bromide hydrobromide for (3-dimethylaminopropyl)-triphenylphosphonium bromide hydrobromide in Example 2 as a colorless oily matter. Mass spectrum (m/z): 337 (M°) for C 21 H 23 O 3 N Example 31 Methyl II-(3-aminopropylidene)-6,II-dihydrodibenz[b.e]oxepin-2-acetate (Compound 27) The desired product is obtained by substituting (3-aminopropyl)-triphenylphosphonium bromide hydrobromide for (3-dimethylaminopropyl)-triphenylphosphonium bromide hydrobromide in Example 2 as a colorless oily matter. Mass spectrum (m/z): 323 (M°) for C 20 H 21 O 3 N Examples 32-33 II-(3-Methylaminopropylidene)-6,II-dihydrodibenz[b.e]oxepin-2-acetic acid (Compound 26) II-(3-Aminopropylidene)-6,II-dihydrodibenz[b.e]oxepin-2-acetic acid (Compound 28) The physicochemical properties of these compounds are shown in Table 15.

Claims: A dibenz[b,e]oxepin compound represented by the formula (I) wherein A represents a carboxyl, a straight or branched (C 1 -C 6 ) alkoxy carbonyl group. -CONHOH or -CONR 1 R 2 wherein R 1 and R 2 are the same or different and represent hydrogen atom or straight or branched (C 1 -C 6 ) alkyl: Y represents -(CH 2 )-, -CHR 3 -(CH 2 ) m - wherein R 3 represents a straight or branched (C 1 -C 6 ) alkyl. and m is 1, 2, 3 or 4, which is the substituent at 2- or 3- position of the mother nucleus and the left side of the group Y is bound to benzen nucleus X represents = N-. =CH- : n is 0, 1, 2. 3 or 4: Z represents 4-methylpiperazino, 4-methylhomopiperazino, piperidino, pyrrolidino, thiomorpholino, morpholino or -NR 6 R 7 wherein R 6 and R 7 are the same or different and represent hydrogen atom or a straight or branched (C 1 -C 6 ) alkyl and ---- means double bond: and the pharmaceutically acceptable salts thereof. A Compound according to claim 1, wherein said salt is selected from acid addition salt, metal salt ammonium salt, organic amine addition, salt, and amino acid addition salt. A compound according to claim 1, wherein A is a member selected from the group consisting of a straight or branched (C 1 -C 6 ) alkoxycarbonyl, -CONR 1 R 2 and carboxyl: Y is bound at 2-position of the mother nucleus; X is a member selected from the group consisting of = N- and = CH-: n is 1 or 2: and Z is a member selected from the group consisting of dimethylamino, diethylamino, methylamino, amino, morpholino and thiomorpholino. A compound according to claim 3, wherein Y is a member selected from the group consisting of -(CH 2 ). and m is 1 or 2. A compound according to claim 4, wherein A is a carboxyl; and X is = CH-. A compound according to claim 1, wherein -Y-A is a member selected from the group consisting of carboxymethyl, X is = CH-, n is 2 and Z is a member selected from the group consisting of dimethylamino. diethylamino, methylamino, amino, morpholino and thiomorpholino. A compound according to claim 1, wherein -Y-A is 2-CH 2 COOH. X is =CH-, n is 2 and Z is dimethylamino. Use of a compound as defined in anyone of claims 1 to 7 for the preparation of medicaments for the therapeutic treatment of allergic and inflammatory diseases.

Inventors: ISHII HIDEE, KUMAZAWA TOSHIAKI, MANABE HARUHIKO, OBASE HIROYUKI, OHMORI KENJI, OSHIMA ETSUO, OTAKI SHIZUO, SHUTO KATSUICHI, TAMURA TADAFUMI, ISHII, HIDEE, KUMAZAWA, TOSHIAKI, MANABE, HARUHIKO, OBASE, HIROYUKI, OHMORI, KENJI, OSHIMA, ETSUO, OTAKI, SHIZUO, SHUTO, KATSUICHI, TAMURA, TADAFUMI, ISHII, HIDEE C/O KYOWA HAKKO KOGGYO CO., LTD, KUMAZAWA, TOSHIAKI C/O KYOWA HAKKO KOGYO CO., LTD, MANABE, HARUHIKO C/O KYOWA HAKKO KOGYO CO., LTD, OBASE, HIROYUKI C/O KYOWA HAKKO KOGYO CO., LTD, OHMORI, KENJI C/O KYOWA HAKKO KOGYO CO., LTD, OSHIMA, ETSUO C/O KYOWA HAKKO KOGYO CO., LTD, OTAKI, SHIZUO C/O KYOWA HAKKO KOGYO CO., LTD, SHUTO, KATSUICHI C/O KYOWA HAKKO KOGYO CO., LTD, TAMURA, TADAFUMI C/O KYOWA HAKKO KOGYO CO., LTD
Applicants: KYOWA HAKKO KOGYO KK, KYOWA HAKKO KOGYO CO., LTD.
Application year: 1987
Main classification: C07D313
IPC codes: A61K31, A61P37, C07D413, C07D405, A61P29, C07D313