THIAZOLIDIN-4-ONE DERIVATIVES AND ACID ADDITION SALTS THEREOF

Abstract: A 2-pyridylthiazolidin-4-one derivative represented by the general formula wherein Ar denotes an aryl group unsubstituted or substitu­ ted with a halogen atom or with a lower alkoxy group; X denotes a straight-chain or branched-chain lower alkylene group or a single bond; R denotes a hydrogen atom, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, acyloxy, di(lower alkyl)amino, hydroxyl or aryl group, or denotes an aryl group substituted with a lower alkoxy group; and Py den­ otes a pyridyl group, and the acid addition salt thereof, have an excellent platelet activating factor antagonism.

Description: FIELD OF THE INVENTION This invention relates to novel 2-pyridylthiazolidin-4-one derivatives which show an excellent antagonism to the platelet activating factor (hereinafter abbreviated as PAF). The platelet activating factor (PAF) is an autacoid present in living body which has been recently identified as acetyl glyceryl ether phosphorylcholine (AGEPC), namely 1-o-hexadecyl/octadecyl-2-o-acetyl-sn-glyceryl-3-phosphoryl-choline [Hanada, D.S. et al., J. Biol. Chem. 255 , 5514 (1980)]. PAF exhibits various physiological activities which include, for example, platelet activation, blood pressure depression, smooth muscle contraction, neutrocyte-, monocyte- and macrophage-activation, increasing viscular permeability, and liver glycogen decomposition acceleration. It is known that these physiological actions are related to many diseases, for example various kinds of inflammation, circulatory diseases, allergic diseases and gastrointestinal diseases. Accordingly, it is the course of nature that more and more scientists have come to focus their attention to work of searching PAF antagonists intended for preventing or curing these PAF-induced diseases. However, although many compounds have been tested up to the present to treat or prevent the PAF-induced diseases, their effectiveness is not yet fully satisfactory. On the other hand, a number of studies have been reported which relate to thiazolidin-4-one derivatives. For example, Surrey has studied the reaction of thioglycolic acid with Schiff base and reported a method of synthesizing thiazolidin-4-one derivatives; these compounds are known to show an anticonvulsant activity [J. Am. Chem. Soc., 70 , 8436-8439 (1948)]. Pennington et al. have reported a method of synthesizing 2-substituted thiazolidin-4-one derivatives and that these derivatives have a antitubercular activity in in vitro experiments [J. Am. Chem. Soc., 75 , 109-114 (1953)]. Surrey et al. have reported a method of synthesizing a certain kind of 2-arylthiazolidin-4-one derivative and that they have an amoebacidal activity (against Endamoeba criceti ) [J. Am. Chem. Soc., 76 , 578-580 (1954)]. Singh has reported methods of synthesis for a number of 5-methyl-3-aryl-2-aryliminothiazolidin-4-one derivatives and described that they show a fungicidal activity on Alternaria solani used as the test, microorganism [J. Indian Chem. Soc., 595-597 (1976)]. Japanese Patent Application Kokoku (Post-Exam. Publn.) No. 17276/73 discloses their suppressive effect on the central nervous system. US-A-4,017,628 (1977) discloses a method of treating the itch of domestic animals using a 2-pyridyl-substituted thiazolidin-4-one derivative. P.B. Patel et al. have reported that 2-aryl-3-axyloxyethylthiazolidin-4-one derivatives show an antiinflammatory action [J. Indian Chem. Soc., 54 (8), 765-768 (1977)]. Further, Jadhav et al. have reported a method of synthesizing a certain kind of 2-methyl-(2-hydroxy-4,5-dimethylphenyl)-3-arylthiazolidin-4-one derivative and that they show a germicidal activity on some kind of fungi ( Helmy nthosporium appatarnae ) [J. Indian Chem. Soc., 424-426 (1978)]. Further, JP-A-55,184/80 discloses that they show a germicidal action for plants and a controlling action for land and aquatic plants. Thus, not a few of the thiazolidin-4-one derivatives show an excellent pharmacological action. SUMMARY OF THE INVENTION After extensive studies under such circumstances, the present inventors have found that 2-pyridyl-thiazolidin-4-one derivatives represented by the general formula [I] wherein Ar denotes an aryl group unsubstituted or substituted with one or more halogen atom(s), or with one or more lower alkyloxy group(s), for example a phenyl group unsubstituted or substituted with one or more halogen atoms or with one or more lower alkoxy groups; X denotes a straight-chain or branched-chain lower alkylene group or a single bond; R denotes a hydrogen atom, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, acyloxy, di(lower alkyl) amino, hydroxy or aryl group, or denotes an aryl group substituted with one or more lower alkyloxy group(s); and Py denotes a pyridyl group, for example, a 2- or 3-pyridyl group, and the acid addition salts thereof, show a selective PAF-antagonism and are very useful as preventive and curative agents for PAF-induced diseases including, for example, various kinds of inflammation, circulatory diseases, allergic dieseases, and gastrointestinal ulceration, and thus accomplished this invention. DESCRIPTION OF THE PREFERRED EMBODIMENT The compounds of this invention will now be described in detail below. In compounds of this invention, the lower alkyl groups are C₁₋₄ alkyl groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl; the lower alkoxy groups are C₁₋₄ alkoxy groups such as methoxy, ethoxy, n-propoxy; the aryl groups are phenyl and naphthyl; the lower alkylene groups are C₁₋₄ alkylene groups such as methylene, ethylene, propylene, trimethylene, tetramethylene, and 1-methyl-trimethylene; the lower alkenyl groups are C₃₋₄ alkenyl groups such as allyl and butenyl; the lower alkynyl groups are C₃₋₄ alkynyl groups such as propargyl; the cycloalkyl groups are C₃₋₇ cycloalkyl groups such as cyclopropyl, cyclopentyl, and cyclohexyl; the acyloxy groups are C₁₋₄ alkanoyloxy groups (such as acetyloxy) or benzoyl; examples of the halogen atoms are fluorine, chlorine, and bromine atoms; and the di(lower alkyl) amino groups are di(C₁₋₄ alkyl) amino groups such as dimethyl amino, diethyl amino, dipropyl amino. The "substituted aryl group" means an aryl group substituted with one or more substituents, said substituents being as mentioned above. Examples of the group X-R are C₁-C₄ alkyl, C₃-C₄ alkenyl, C₃-C₄ alkynyl, phenylethyl, (C₁-C₄ alkoxy)-substituted phenyl-ethyl, (C₂-C₄) alkanoyloxy (C₂-C₄) alkyl and di(C₁₋₄ alkyl) amino C₂₋₄ alkyl and, more specifically methyl, allyl, propargyl, acetoxyethyl and dimethylaminoethyl. The pyridyl group denoted by Py may be bonded to the 2-position of the thiazolidin-4-one ring at any of the 2-, 3- and 4-position of the pyridine ring. The salts of the thiazolidin-4-one derivatives represented by the general formula (I) may be any of those pharmaceutically acceptable salts and include the salts of inorganic and organic acids, e.g. the salts of mineral acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, and phosphoric acid; the salts of organic carboxylic acids such as formic acid, acetic acid, fumaric acid, maleic acid, malic acid, tartaric acid, and aspartic acid; and the salts of sulfonic acids such as methane-sulfonic acid, benzenesulfonic acid, toluenesulfonic acid, hydroxybenzenesulfonic acid, dihydroxybenzenesulfonic acid, and naphthalenesulfonic acid. The compounds of this invention include their optical isomers, geometrical isomers and tautomers, and further all of the hydrates and the crystal forms thereof. The thiazolidin-4-one derivatives represented by the general formula [I] can be prepared, for example, by the following methods. wherein Ar, Py, X and R are as defined above. Thus, they can be prepared by subjecting the compounds [II] and [III] to ring closure in an organic solvent. The organic solvent may be a common inert solvent such as benzene, toluene, xylene, dichloromethane, 1,2-dichloroethane, chloroform, and tetrahydrofuran. The reaction can be carried out at a temperature from 20°C to the reflux temperature. It is preferable to conduct it at the reflux temperature while azeotropically dehydrating to promote the reaction. wherein Ar, Py, X and R are as defined above. The compound [I] can also be obtained by allowing the compounds [III], [IV] and [V] to react in an organic solvent. The organic solvent to be used may be a common inert solvent such as benzene, toluene, xylene, dichloro-methane, 1,2-dichloroethane, chloroform, and tetrahydrofuran. The reaction can be carried out at a temperature from 20°C to the reflux temperature, but preferably at the reflux temperature with azeotropically dehydrating. These starting compounds are well-known or can be prepared by known methods. For example, the compounds represented by the formulae [II] and [III] could be obtained by the following methods, as described later in Reference Examples. wherein Ar, Py, X and R are as defined above. Thus, the starting compound [IX] was esterified according to the method described in Shin Jikken Kagaku Koza (A New Course of Experimental Chemistry), Vol. 14, p. 1002, to give an ester [VIII], which was then halogenated according to the method described in Shin Jikken Kagaku Koza, Vol. 14, p. 339, to give a brominated compound [VII]. The compound [VII] was further converted to a thiol ester compound [VI] according to the method described in Shin Jikken Kagaku Koza, vol. 14, p. 1712, and then the compound [VI] was hydrolyzed with a base such as sodium hydroxide or potassium hydroxide in a water-alcohol mixed solvent, to give a mercaptan derivative [II]. The Schiff base compound [III] was obtained by subjecting an aldehyde [IV] and a primary amine [V] to dehydration condensation according to the method described in Shin Jikken Kagaku Koza, Vol. 14, p. 1410. When the compounds of this invention represented by the general formula [I] mentioned above and their salts are used as a medicinal agents, they can be administered in the form of a pharmaceutical composition comprising as active ingredient a pharmaceutically effective amount of such compounds (in which at least one of such compounds is present) and at least one pharmaceutically acceptable inert carrier or diluent. They can be administered orally or parenterally. Thus, they can be administered orally in a conventionally used dosage form such as tablets, capsules, syrup, suspension and solution; or they can be made up into liquid preparations including their solution, emulsion and suspension and administered parenterally as injections. Further, they can be administered rectally in the form of suppositories, and also administered in the form of inhalation spray or endermic agents. The pharmaceutical preparations of suitable dosage forms mentioned above may be prepared by compounding the active compound with conventional acceptable carriers, excipients, binders, stabilizers etc. For use in the form of injections, acceptable buffers, solubilizing aids, isotonificating agents, etc. may be added thereto. Although the dose and the frequency of administration vary depending on the conditions, age, and weight of the patient, the dosage form, and other factors, a normal dose is about 1 to 5,000 mg, preferably 10 to 300 mg, in single or divided doses, per day for an adult. EFFECT OF THE INVENTION It has been revealed that the compound [I] of this invention shows a pharmacological action desirable as a curative agent for PAF-induced diseases. Namely, the compound [I] of this invention exhibits a powerful and selective PAF antagonism. The pharmacological effect of the compound of this invention will be described in detail below. Inhibition of PAF-induced platelet aggregation in vitro test : The inhibition of PAF-induced platelet aggregation was examined by use of a platelet-rich plasma [PRP] of a rabbit according to the method of Mustard et al. [J. F. Mustard et al., J. Lab. Clin. Med., 64 , 548 (1964)], which is an improved version of the method of Born [G.V.R. Born, J. Physiol., London, 162 , 67 (1962)]. Thus, 80 to 100 ml of blood per animal was collected from the carotid artery of a Japanese white crossbred male rabbit without anesthesia into a polyethylene vessel in which 1/10 the volume of a 3.8% sodium citrate solution had been placed beforehand. A portion (about 3 ml) of the blood thus collected was subjected to high speed centrifugation (11,000 rpm, 60 seconds) to obtain a platelet-poor plasma (PPP) as supernatant. The remainder of the blood was subjected to low speed centrifugation (1,000 rpm, 10 minutes) to obtain a platelet-rich plasma (PRP) as supernatant. The platelet aggregation was evaluated by nephelometry, the determination being made with PRP stirred at 1,000 rpm at 37°C by use of an aggregator (Hematracer, Niko Bioscience Co.). The platelet aggregation activity was expressed in terms of the per cent of light transmission, that of PRP being taken as 0% and that of PPP being taken as 100%. A 0.2 ml portion of PRP was placed in a glass cuvette containing a silicone-treated iron stirring rod, and 2 µl of dimethyl sulfoxide was added thereto. After 2 minutes, a PAF solution in 0.25% BSA physiological saline was added thereto to give a final concentration of PAF of 0.005 µg/µl and the maximum aggregation was determined. To examine the inhibitory activity of test compounds for the platelet aggregation caused by PAF, 2 µl of a test compound dissolved in dimethyl sulfoxide was added in place of dimethyl sulfoxide described above. The PAF inhibitory rate of a test compound was calculated according to the following equation: The results thus obtained are shown in Table 1. The IC₅₀ of the compound of Example 1 was 5.0 µg/ml. The inhibitory rate for blood pressure depression caused by PAF was calculated according to the following equation: Inhibition of pressure depression caused by PAF, in vivo test , (Blood pressure determination method) (1) A rat was anesthetized with urethane (6.25 mg/kg intravenous injection) and cannulated through the carotid artery and the jugular vein. The carotid artery cannula was connected to a hemomanometer transducer to determine the blood pressure. The compound of example 1 was suspended in 10% Nikkol® liquid to a concentration of 30 mg/ml, and 1 ml/kg of the resulting suspension was administered through the jugular vein cannula. After 5 minutes, 1 ml of a 0.1 µg/ml PAF solution was administered through the jugular vein cannula and then the maximum blood pressure depression was determined. For a control test, the vehicle (10% Nikkol® liquid) was administered in place of the compound of Example 1. (2) The compound of example 1 was suspended in a 0.5% methylcellulose solution to a concentration of 50 mg/ml, and 1 ml/kg of the resulting suspension was orally administered to a rat. After 30 minutes from the administration, the rat was anesthetized with urethane (6,25 mg/kg intravenous injection) and cannulated through the carotid artery and the jugular vein. The carotid artery cannula was used for blood pressure determination and the jugular vein cannula for PAF intravenous injection. After 60 minutes from the administration of the medicine, 1 ml of a 0.1 µg/ml PAF solution was administered and then the maximum blood pressure depression was determined. For a control test, the vehicle (10% Nikkol® liquid) was administered in place of the compound of Example 1. Inhibition of platelet aggregation, outside-living-body test The test compound was intravenously administered (30 mg/kg) to a rabbit or orally administered (50 mg/kg) to a guinea pig. Blood samples were collected, and the extent of platelet aggregation caused by 10⁻¹²-10⁻⁶ M of PAF was examined. The results are shown in Table 2. The numerical values in the Table show the PAF concentrations (EC₅₀ nM) necessary for causing an aggregation corresponding to 50% of the maximum PAF reaction. As stated in the foregoing, the compound [I] of this invention shows a powerful and highly selective PAF antagonism. This antagonism has been confirmed not only in in vitro test but also in outside-living-body test as well as in in vivo test. Further, the compound [I] of this invention shows a prolonged duration of action in living body which could not be found in prior art compounds. Accordingly, the compound [I] of this invention is very useful as a preventive and curative agent for PAF-induced diseases, for example various kinds of inflamation such as nephritis or rheumatism, circulatory diseases such as DIC* or endotoxin shock, allergic diseases such as asthma and gastrointestinal ulceration such as gastric ulcer. *DIC (disseminated intervascular coagulation) This invention is further described in detail below by way of Examples and Referential Examples, but it is in no way limited thereto. Referential Example 1 Methyl (4-chlorophenyl)acetate To a solution of 100 g (0.59 mole) of 4-chloro-phenylacetic acid in 165 ml of 1,2-dichloroethane and 96 ml (2.4 moles) of methanol was added 2.75 ml of concentrated sulfuric acid, and the mixture was refluxed for 6 hours. It was then cooled, poured into an aqueous sodium bicarbonate solution and stirred. Tie organic layer was separated, dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated to dryness to give 102 g (94% yield) of methyl (4-chlorophenyl)acetate. NMR (CDCl₃) δ ppm; 3.60 (2H, s), 3.70 (3H, s), 7.15-7.35 (4H, s) Referential Example 2 Methyl (4-chlorophenyl)bromoacetate To a solution of 102 g (0.55 mole) of methyl (4-chlorophenyl)acetate in 100 ml of carbon tetrachloride was added 97.9 g (0.55 mole) of N-bromosuccinimide. The resulting mixture was refluxed and irradiated with a 500 W bromo lamp for 5 hours. It was then cooled, filtered, and the filtrate was evaporated to dryness to give 150 g (103% yield) of methyl (4-chlorophenyl)bromoacetate. NMR (CDCl₃) δ ppm; 3.79 (3H, s), 5,31 (1H, s), 7.3-7.7 (4H, s) Referential Example 3 Methyl α-(4-chlorophenyl)-α-acetylthioacetate Under nitrogen atmosphere, 300 ml of dry dymethylformamide was added to 22.0 g (0.55 mole) of a 60% oily suspension of sodium hydride. To the above mixture was added dropwise 46.0 g (0.61 mole) of thioacetic acid at 0 to 10°C. After the dropwise addition, the resulting mixture was maintained at 0 to 10°C for one hour. Then, a solution of 150 g (0.55 mole) of methyl (4-chlorophenyl)bromoacetate in 200 ml of dry dimethylformamide was added dropwise at 0 to 10°C thereto. Thereafter, the reaction mixture was kept at the same temperature for one hour. The reaction mixture was poured into a 10% aqueous sodium chloride solution and extracted twice with benzene. The organic layer was washed with a 5% aqueous sodium bicarbonate solution, then twice with a 10% aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated. The residue thus obtained was purified by silica gel chromatography (5% ethyl acetate-hexane) to give 128.0 g (95% yield) of methyl α-(4-chlorophenyl)-α-acetylthio-acetate. NMR (CDCl₃) δ ppm; 2.35 (3H, s), 3.74 (3H, s), 5.28 (1H, s), 7.25-7.40 (4H, m) Referential Example 4 α-(4-Chlorophenyl)-α-mercaptoacetic acid One hundred grams (0.39 mole) of methyl α-(4-chlorophenyl)-α-acetylthioacetate was dissolved in 350 ml of methanol. Then, a solution of 62.4 g (1.56 moles) of sodium hydroxide in 150 ml of water was added thereto, and the mixture was refluxed for 5 hours. After being cooled, the reaction mixture was poured into a 10% aqueous sodium chloride solution and washed twice with hexane. The aqueous layer was adjusted to a pH of 1 to 2 with concentrated hydrochloric acid, and extracted twice with benzene. The organic layer was washed with a 10% aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and evaporated to dryness to give 68 g (86.8% yield) of α-(4-chlorophenyl)-α-mercaptoacetic acid. NMR (CDCl₃) δ ppm; 2.62 (1H, d, J = 7.6 Hz), 4.67 (1H, d, J = 7.6 Hz), 7.3-7.45 (4H, s) Referential Example 5 N-Nicotinylidenemethylamine To a solution of 10.7 g (0.1 mole) of nicotinic aldehyde in 100 ml of toluene was added 233 g (0.3 mole) of a 40% aqueous methylamine solution, and the mixture was subjected to azeotropic dehydration for 3 hours. The reaction liquid was concentrated under reduced pressure to give 11.7 g of N-nicotinylidenemethylamine. NMR (CDCl₃) δ ppm; 3.53 (3H, d, J = 1.7 Hz), 7.3-8.85 (5H, m) Example 1 Synthesis of 5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)-thiazolidin-4-one A 10.0 g (0.049 mole) portion of α-(4-chlorophenyl)-α-mercaptoacetic acid prepared in Referential Example 4 and 5.88 g (0.049 mole) of N-nicotinylidene-methylamine prepared in Referential Example 5 were dissolved in 100 ml of toluene, and the solution was subjected to azeotropic dehydration for 2 hours. The reaction mixture was cooled, washed with a 5% aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue thus obtained was purified by silica gel chromatography (5% acetone-chloroform) and recrystallized from ether to give 13.5 g (90.0% yield) of 5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one, m.p. 100 to 101.5°C (uncorrected). Example 2 Three grams of 5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one obtained in Example 1 was purified by liquid chromatography [Lichroprep® Si-60 (40-63 µm), mobile phase: ethanol-hexane = 1: 9] to obtain the isomer I and the isomer II. Example 3 5-(4-Chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one To 50 ml of toluene were added 5.0 g (0.025 mole) of α-(4-chlorophenyl)-α-mercaptoacetic acid prepared in Referential Example 4, 2.64 g (0.025 mole) of nicotinic aldehyde and 5.75 g (0.074 mole) of a 40% aqueous methyl-amine solution, and the mixture was subjected to azeotropic dehydration for 3 hours. The reaction mixture was cooled, and concentrated under reduced pressure. The residue obtained was purified by silica gel chromatography (5% acetone-chloroform) and recrystallized from ether to give 6.59 g (87.6% yield of 5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)-thiazolidin-4-one, m.p. 100 to 101.5°C (uncorrected). In the same manner as in Example 1 or 3, compounds of Examples 4 to 35 were obtained, which are enumerated in Table 3.

Claims: Claims for the contracting States: GB, DE, FR, IT, NL, SE, CH/LI, AT, BE, LU 1. A 2-pyridylthiazolidin-4-one derivative represented by the general formula wherein Ar denotes a phenyl or naphthyl group, which group is unsubstituted or substituted with one or more halogen atoms or with one or more C₁-C₄ alkoxy groups, X denotes a straight-chain or branched-chain C₁-C₄ alkylene group or a single bond; R denotes a hydrogen atom, C₁-C₄ alkyl, C₃-C₄ alkenyl, C₃-C₄ alkynyl, C₃-C₇ cycloalkyl, C₁-C₄ alkanoyloxy, benzoyl, di(C₁-C₄ alkyl)amino, hydroxyl or phenyl group or denotes a phenyl group substituted with at least one C₁-C₄ alkoxy group; and Py denotes a pyridyl group; or an acid addition salt thereof. 2. A compound according to claim 1, wherein Py is the 2-pyridyl group or the 3-pyridyl group. 3. A compound according to claim 1 or 2, wherein Ar is a phenyl group unsubstituted or substituted with one or more halogen atoms or with one or more C₁-C₄ alkoxy groups. 4. A compound according to any preceding claim, wherein X-R is a C₁-C₄ alkyl, C₃-C₄ alkenyl, C₃-C₄ alkynyl, phenylethyl, (C₁-C₄ alkoxy)-substituted phenylethyl, (C₂-C₄)alkanoyloxy (C₂-C₄)alkyl or di(C₁-C₄)alkylamino(C₂-C₄)alkyl group. 5. A compound according to claim 4, wherein X-R is methyl, allyl, propargyl, acetoxyethyl or dimethylaminoethyl. 6. A method of preparing a 2-pyridylthiazolidin-4-one derivative of the formula (I) given and defined in claim 1, or a pharmaceutically acceptable salt thereof, which method comprises reacting in an inert solvent a compound represented by the general formula (II) wherein Ar is as defined in claim 1, with a compound represented by the general formula (III) Py-CH=N-X-R wherein Py, X adn R are as defined in claim 1, to obtain the said 2-pyridylthiazolidin-4-one derivative of the formula (I), and optionally salifying the resultant product. 7. A method according to claim 6, wherein Py is the 2-pyridyl group or the 3-pyridyl group. 8. A method of preparing a 2-pyridylthiazolidin-4-one derivative of the formula (I), given and defined in claim 1, or a pharmaceutically acceptable salt thereof, which method comprises reacting in an inert solvent a compound represented by the general formula (II) wherein Ar is as defined in claim 1, with a compound represented by the general formula (IV) Py-CHO wherein Py denotes a pyridyl group, and with a compound represented by the general formula (V) H₂N-X-R wherein X and R are as defined in claim 1, to obtain the said 2-pyridylthiazolidin-4-one derivative of by the formula (I), and optionally salifying the resultant product. 9. A method according to claim 8, wherein Py is the 2-pyridyl group or the 3-pyridyl group. 10. A pharmaceutical composition for treatment of a disease caused by platelet activating factor, which comprises as an active ingredient at least one compound as claimed in claim 1, and at least one pharmaceutically acceptable inert carrier or diluent. 11. A pharmaceutical composition according to claim 10, wherein the disease is inflammation, a circulatory diesease, gastrointestinal ulceration or an allergy disease. 12. A pharmaceutical composition according to claim 11, wherein the circulatory disease is DIC (disseminated intervascular coagulation) or endotoxin shock. 13. A pharmaceutical composition according to claim 11, wherein the allergy disease is asthma. 14. A pharmaceutical composition according to claim 11, wherein the gastrointestinal ulceration is a gastric ulcer. 15. A pharmaceutical composition according to claim 11, wherein the inflammation is nephritis or rheumatism. 16. Use of at least one compound of the formula I, given and defined in claim 1, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of a disease caused by platelet activating factor. 17. A compound of the formula (I), given and defined in claim 1, or its pharmaceutically acceptable acid addition salt, for use as an active therapeutic substance. Claim for the contracting State: ES 1. A method of preparing a 2-pyridylthiazolidin-4-one derivative represented by the general formula wherein Ar denotes a phenyl or naphthyl group unsubstituted or substituted with one or more halogen atoms or with one or more C₁-C₄ alkoxy groups, X denotes a straight-chain or branched-chain C₁-C₄ alkylene group or a single bond; R denotes a hydrogen atom, C₁-C₄ alkyl, C₃-C₄ alkenyl, C₃-C₄ alkynyl, C₃-C₇ cycloalkyl, C₁-C₄ alkanoyloxy, benzoyl, di(C₁-C₄ alkyl)amino, hydroxyl or phenyl group or denotes an aryl group substituted with at least one C₁-C₄ alkoxy group; and Py denotes a pyridyl group, or an acid addition salt thereof, which method comprises reacting in an inert solvent a compound represented by the general formula (II) wherein Ar is as defined above, with a compound represented by the general formula (III) Py-CH=N-X-R wherein Py, X and R are as defined above, to obtain a 2-pyridylthiazolidin-4-one derivative represented by the general formula (I) wherein Ar, Py, X and R are as defined above, to obtain the said 2-pyridylthiazolidin-4-one derivative of the formula (I), and optionally salifying the resultant product. 2. A method according to claim 1, wherein Py is the 2-pyridyl group or the 3-pyridyl group. 3. A method of preparing a 2-pyridylthiazolidin-4-one derivative of the formula (I), given and defined in claim 1, which method comprises reacting in an inert solvent a compound represented by the general formula (II) wherein Ar is as defined in claim 1, with a compound represented by the general formula (IV) Py-CHO wherein Py is as defined in claim 1, and with a compound represented by the general formula (V) H₂N-X-R wherein X and R are as defined in claim 1, to obtain the 2-pyridylthiazolidin-4-one derivative of the generally formula (I), and optionally salifying the resultant product. 4. A method according to any preceding claim, wherein Py is the 2-pyridyl group or the 3-pyridyl group. 5. A method according to any preceding claim, wherein Ar is a phenyl group unsubstituted or substituted with one or more halogen atoms or with one or more C₁-C₄ alkoxy groups. 6. A method according to any preceding claim, wherein X-R is a C₁-C₄ alkyl, C₃-C₄ alkenyl, C₃-C₄ alkynyl, phenylethyl, (C₁-C₄ alkoxy)-substituted phenylethyl, (C₂-C₄)alkanoyloxy (C₂-C₄)alkyl, or di(C₁-C₄)-alkylamino(C₂-C₄)alkyl group. 7. A method according to claim 6, wherein X-R is methyl, allyl, propargyl, acetoxyethyl, or dimethylaminoethyl.

Inventors: ATSUMI, TOSHIO, ENOMOTO, MASAO, KOJIMA, ATSUYUKI, KOMURO, YOSHIHIRO, MIZUTANI, MASATO, MURAOKA, MASAMI, ONO, KEIICHI, SANEMITSU, YUZURU
Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
Application year: 1987
Main classification: C07D417
IPC codes: A61P11, A61P7, A61K31, A61P29, A61P1, A61P9, C07D417