NOVEL DIARYLALKANOIDS HAVING ACTIVITY AS LIPOXYGENASE INHIBITORS

Abstract: The present invention is novel diarylalkanoids having ac­ tivity as lipoxygenase inhibitors, novel pharmaceutical com­ positions therefor, and novel methods of use in treating asthma, allergies, cardiovascular diseases, migraines, psoriasis and immunoinflammatory diseases for di­ arylalkanoids The compounds of this invention are also use­ ful as cytoprotective agents.

Description: The present invention relates to novel compounds, pharmaceutical compositions, the preparation of the novel compounds and methods of use for the manufacture of a medicament for the treatment of diseases in which 5-lipoxygenase enzyme activity contributes to the pathological condition. Thus, the novel compounds of the present invention have activity useful for treating asthma, allergies, cardiovascular diseases, migraines, psoriasis, immunoinflammatory conditions, and as cytoprotective agents. More particularly the novel compounds having the formula I as defined below inhibit 5-lipoxygenase enzymes. Lipoxygenase pathway products such as the leukotrienes B4, C4, D4, and E4, 5-hydroxyeicosatetraenoic acid, 5-hydroperoxyeicosatetraenoic acid, and 12-hydroxyeicosatraenoic acid are related to the above described conditions. Specific conditions for use of the present novel lipoxygenase-inhibiting compounds, pharmaceutical compositions thereof and the novel method of use in accordance with the present invention include allergy; asthma; arthritis; skin disorders including psoriasis and acne; inflammation including inflammatory bowel diseases or pain; and cardiovascular disorders including myocardial ischemia and infarction, angina, arrhythmias, stroke, migraine and atherosclerosis. Itokawa, H. et al, "Synthesis of Diarylheptanoids and Assessment of Their Pungency," Chem. Pharm. Bull. , 31 , 2491 (1983) and "A Pungent Principle from Alpina Oxyphylla ," Phytochemistry , 21 , 241 (1982) disclose compounds: and wherein Q₁ and Q₂ are independently hydrogen, hydroxy or methoxy, correlating structure and pungency with previously published pain-producing experiments on capsaicin congeners. European Patent Application 163270A also discloses some Lipoxygenase inhibitions which are analogs of compound A. However this structure does not comprise the oxime moiety of the present invention. Itokawa, H. et al, "Two New Diarylheptanoids from Alpinia Offcinarum Hance," Chem. Pharm. Bull. , 29 (8) 2383-5 (1981) disclose a compound from those of formula B above as a fraction of an extract which extract was used in Chinese medicine to relieve gastro-intestinal disorders as well as fractions of which were known to contract the ileum of guinea pigs. Further, prostaglandin-biosynthesis inhibition having use as an antiinflammatory, antipyretic, analgesic or antiarterioscleratic is disclosed in J5 9098-026-A (Derwent Abstract No. 84-178335/29) for the compound C as follows: wherein Q₁ and Q₂ are within the groups defined above therefor and Q₃ is hydrogen or together with Q₄ is ; Q₅ and Q₆ are hydrogen, optionally form a double bond between the 5- and 4-position carbon or together are . European Patent Application 149,242 discloses contain phenyl-oximes of formula D: in which Q₇ is hydrogen, alkyl, COQ₉ or CONHQ₉ wherein Q₉ is an aliphatic or an aromatic group, R is alkyl or aralkyl, and the phenyl to which attaches may be substituted at the 2-, and/or 4-position by alkyl or chlorine and at the 3-position by alkyl or OQ' wherein Q' is alkyl, cycloalkyl or aralkyl. The compounds of formula D are said to be useful as lipoxygenase inhibitors. The oxime-group is directly attached to the phenyl ring and hence these compounds represent a different structure. Patent Abstracts of Japan, Vol.8, No. 212 (C-244) [1649] and JP-A-59 98026 describe inhibitors for the biosynthesis of prostaglandin. The compounds are somehow similar in their structure but do not show the oxime moiety of the present invention. However, the present novel compounds, pharmaceutical compositions and novel methods of using compounds as defined in the present invention are combinations of substituents on various moieties that are not taught or are unobvious from the very limited disclosures of the above references. The compounds of the limited disclosures are excluded herein. Of lesser interest are diaryl containing compounds linked by carbons having 2 alternating oxygen containing carbons. These compounds are related to curcumin and are disclosed in the European Patent Application 149,242 noted above; by Rao, et al in "Antiinflammatory Activity of Curcumin Analogues," Indian J. Med. Res. , 75 574-8 (April 1982), and by Pabon, "A Synthesis of Curcumin and Related Compounds," Recueil , 83 379-386 (1964). The present invention is a novel compound of the formula: or pharmaceutically acceptable base or acid addition salts thereof, wherein (a) R₁ is (i) hydroxy, (ii) lower alkoxy, (iii) COOR₃ wherein R₃ is hydrogen or lower alkyl, (iv) lower alkanoyl, (v) NR₃R₄ wherein R₃ and R₄ are independently hydrogen or lower alkyl, wherein R₃ is independently as defined above, (vii) wherein R₃ is independently as defined above, (viii) wherein R₃ is independently as defined above, or (ix) wherein R₃ is independently as defined above; (b) R₂ is (i) hydroxy, (ii) lower alkoxy, (iii) lower thioalkoxy, (iv) lower alkanoyl, (v) halogen, (vi) trifluoromethyl, (vii) hydroxymethyl, (viii) lower alkyl, (ix) NR₃R₄ wherein R₃ and R₄ are independently hydrogen or lower alkyl, (x) nitro, (xi) wherein R₃ is independently as defined above, (xii) wherein R₃ is independently as defined above, (xiii) wherein R₃ is independently as defined above, (xiv) wherein R₃ is independently as defined above, or (xv) wherein R₃ is independently as defined above; (c) T is (i) hydrogen, (ii) lower alkyl, (iii) hydroxy, (iv) lower alkanoyl, (v) NR₃R₄ wherein R₃ and R₄ are independently as defined above, (vi) nitro, (vii) halogen, (viii) trifluoromethyl, (ix) lower alkoxy, (x) lower thioalkoxy, (xi) wherein R₃ is independently as defined above, (xii) wherein R₃ is independently as defined above, or (xiii) wherein R₃ is independently as defined above, (xiv) wherein R₃ is as defined above; (d) X and Y are independently (i) (CH₂) n , (ii) CH=CH, (iii) (CH₂) n M, wherein n is an integer of one to four and M is oxygen, NR₃ wherein R₃ is independently as defined above, or S(O)g wherein g is zero, one or two, or (iv) CH=CH(CO₂R₃) wherein R₃ is independently as defined above; (e) Ar is (i) phenyl or naphthyl each of which is unsubstituted or substituted by one, two or three substituents comprising one or more of each of lower alkyl, hydroxy, lower alkoxy, lower thioalkoxy, lower alkanoyl, halogen, trifluoromethyl, lower carboalkoxy, hydroxymethyl, NR₃R₄ wherein R₃ and R₄ are independently as defined above, nitro, COR₃ wherein R₃ is independently as defined above, or wherein R₃ and R₄ are independently as defined above, or (ii) a heteroaryl unsubstituted or substituted on one or two carbons by one or more of each of lower alkyl, hydroxy, lower alkoxy, lower alkanoyloxy, lower carboalkoxy, halogen, trifluoromethyl, hydroxymethyl, NR₃R₄ wherein R₃ and R₄ are independently as defined above, or wherein R₃ is independently as defined above; in which the heteroaryl comprises pyrrolyl, furanyl, thiophenyl, oxazolyl, thiazolyl, imidazolyl, isothiazolyl, isoxazolyl, or pyrazolyl. The present invention also relates to a pharmaceutical composition useful for treating a disease such as allergy, asthma, arthritis, psoriasis, acne, inflammation, pain, ulcerogenic, or cardiovascular disorders comprising an antiallergy, anti-asthma, antiarthritis, antipsoriatic, antiacne, antiinflammatory, analgesic, cytoprotective or cardiovascular beneficially comprising an effective amount of the compound I as defined above and a pharmaceutically acceptable carrier, and to the use of compounds I for the manufacture of a medicament for treating a mammal having one of the diseases noted above by administering to such mammals a dosage form of a compound of the formula I wherein R₁, R₂, T, X, Y and Ar are as defined above. Finally, the present invention is a process for preparing compounds of formula I as defined above. In the compounds of formula I the term "lower alkyl" is meant to include a straight or branched alkyl group having one to four carbon atoms, such as, for example, methyl, ethyl, propyl, or butyl and isomers thereof. Halogen includes particularly fluorine, chlorine or bromine. Lower alkoxy and thioalkoxy are O-alkyl or S-alkyl, respectively, of from one to four carbon atoms as defined above for "lower alkyl". Lower alkanoyl is a alkyl group having lower alkyl as defined above. Appropriate compounds of formula I are useful in the free base form, in the form of base salts where possible, and in the form of acid addition salts. The three forms are within the scope of the invention. In practice, use of salt form amounts to use of the base form. Pharmaceutically acceptable salts within the scope of the invention are those derived from mineral acids such as hydrochloric acid and sulfuric acid; and organic acids such as ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, and the like, giving the hydrochloride, sulfamate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate, and the like, respectively or those derived from bases such as suitable organic and inorganic bases. Examples of suitable inorganic bases for the formation of salts of compounds of this invention include the hydroxides, carbonates, and bicarbonates of ammonia, sodium, lithium, potassium, calcium, magnesium, aluminum, zinc, and the like. Salts may also be formed with suitable organic bases. Bases suitable for the formation of pharmaceutically acceptable base addition salts with compounds of the present invention include organic bases which are nontoxic and strong enough to form such salts. These organic bases form a class whose limits are readily understood by those skilled in the art. Merely for purposes of illustration, the class may be said to include mono-, di-, and trialkylamines, such as methylamine, dimethylamine, and triethylamine; mono-, di- or trihydroxyalkylamines such as mono-, di- and triethanolamine; amino acids such as arginine, and lysine; guanidine; N -methylglucosamine; N -methylglucamine; L-glutamine; N -methylpiperazine; morpholine; ethylenediamine; N -benzylphenethylamine; tris(hydroxymethyl)aminomethane; and the like. (See for example, "Pharmaceutical Salts," J. Pharm. Sci. 66 (1):1-19 (1977).) The acid addition salts of said basic compounds are prepared either by dissolving the free base of compound I in aqueous or aqueous alcohol solution or other suitable solvents containing the appropriate acid or base and isolating the salt by evaporating the solution, or by reacting the free base of compound I with an acid as well as reacting compound I having an acid group thereon with a base such that the reactions are in an organic solvent, in which case the salt separates directly or can be obtained by concentration of the solution. The compounds of the invention may contain an asymmetric carbon atom. Thus, the invention includes the individual stereoisomers, and mixtures thereof. The individual isomers may be prepared or isolated by methods known in the art. Compounds of the present invention that are preferred are of formula I wherein R₃ is hydrogen and Y is (CH₂)₂. Most preferred compounds of the present invention are as follows: 1-Hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl, oxime; 1-Hepten-3-one, 1-(3,4-dihydroxyphenyl)-7-phenyl, oxime; 1-Penten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-5-phenyl, oxime; 1-Penten-3-one, 1-(3-amino-4-hydroxyphenyl)-5-phenyl, oxime, (both isomer A and isomer B); 1-(4-Hydroxy-3-methoxyphenyl)-4-phenoxyl-1-buten-3-one oxime; 1-(4-Hydroxy-3-methoxyphenyl)-6-phenoxyl-1-hexen-3-one oxime; and 1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-one, O-methyl oxime. The present invention is also a pharmaceutical composition comprising an effective amount of a compound having the formula I as defined above together with a pharmaceutically acceptable carrier. An effective amount is the amount useful for treating or ameliorating a number of diseases or conditions comprising an inhibition of a lipoxygenase effect. The diseases or conditions are readily recognized for the pathogenesis affected by the inhibitory lipoxygenase effect as recited herein. Thus, in accordance with the present invention, another aspect of the invention, provides the use of compounds I for the manufacture of a medicament useful for administering to mammals, including humans, in need of treatment or amelioration of diseases or conditions an amount effective for treatment of the diseases or conditions of a compound or composition having the formula I as defined above. The need is evident for diseases or conditions benefiting from inhibition of a lipoxygenase effect. By virtue of the activity of the compounds having the formula I of the present invention as inhibitors of 5-lipoxygenase such compounds are useful in treating asthmas and allergies as well as cardiovascular disorders, migraine, and immuno-inflammatory conditions as recited above. The antiasthma and antiallergic activity provides medicaments for the treatment of hypersensitivity reaction having broad symptoms. For example, the symptoms may include dermatitis, lacrimation, nasal discharge, coughing, sneezing, nausea, vomiting, diarrhea, difficulty in breathing, pain, inflammation, and in severe cases, anaphylactic shock and circulatory collapse. The symptoms may be found in man as well as other animals suffering from bronchial asthma, seasonal pollinosis (e.g., hay fever), allergic rhinitis, urticaria, allergic conjunctivitis, food allergies, and anaphylactoid reactions. Likewise, the activity of the compounds of formula I provides medicaments for the treatment of cardiovascular disorders, particularly ischemia and myocardial infarctions. The symptoms of a subject having a cardiovascular disorder may be determined by special diagnostic procedures directed to subjects having a history, general physical appearance and then detailed deviations from normal appearances suggesting a cardiovascular disorder. Such disorders are also found in man as well as other mammals. Symptoms of the disorders are described extensively in The Merck Manual 14th ed., (1982). Further, medicaments are provided by the compounds of formula I herein for migraine, stroke and inflammation. The symptoms requiring treatment for these purposes are also readily recognized, particularly for migraine in man and/or inflammation in man as well as other mammals. The compounds of this invention are also useful as cytoprotective agents. Pharmaceutical compositions which also are the present invention are prepared from the compound of formula I and salts thereof described as the present invention having inert pharmaceutical carriers. The compositions may be either solid or liquid. A physician or veterinarian of ordinary skill readily determines a subject who is exhibiting symptoms described herein. Regardless of the route of administration selected, the compounds of the present invention are formulated into pharmaceutically acceptable dosage forms by conventional methods known to the pharmaceutical art. The compounds can be administered in such oral unit dosage forms such as tablets, capsules, pills, powders, or granules. They also may be administered rectally or vaginally in such forms as suppositories or bougies; they may also be introduced parenterally (e.g., subcutaneously, intravenously, or intramuscularly), using forms known to the pharmaceutical art. They are also introduced directly to an affected area (e.g., in the form of eye drops or by inhalation). For the treatment of asthma or allergies such as erythema, and dermatological disorders such as psoriasis and acne, the compounds of the present invention may also be administered topically in the form of ointments, creams, gels, or the like. However, in general, the preferred route of administration is orally. An effective but nontoxic quantity of the compound is employed in treatment. The ordinarily skilled physician or veterinarian will readily determine and prescribe the effective amount of the compound to prevent or arrest the progress of the condition for which treatment is administered. In so proceeding, the physician or veterinarian could employ relatively low dosages at first, subsequently increasing the dose until a maximum response is obtained. Initial dosages of the compounds of the invention having formula I are ordinarily in the area of 10 mg up to 2 g per day orally, preferably 10 mg to 500 mg per dose orally, given from one to four times daily or as needed. When other forms of administration are employed equivalent doses are administered. The compounds of the invention are capable of forming both pharmaceutically acceptable acid addition and/or base salts. Base salts are formed with metals or amines, such as ammonium, alkali, and alkaline earth metals or organic amines. Examples of metals used as cations are sodium, potassium, magnesium, calcium, and the like. Examples of suitable amines are N,N'-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, N-methylflucamine, and procaine. Pharmaceutically acceptable acid addition salts are formed with organic and inorganic acids. Examples of suitable acids for salt formation are hydrochloric, sulfuric, phosphoric, acetic, citric, oxalic, malonic, salicylic, malic, gluconic, fumaric, succinic, ascorbic, maleic, methanesulfonic, arginine, and the like. The salts are prepared by contacting the free base form with a sufficient amount of the desired acid to produce either a mono or di, etc. salt in the conventional manner. The free base forms may be regenerated by treating the salt form with a base. For example, dilute solutions of aqueous base may be utilized. Dilute aqueous sodium hydroxide, potassium carbonate, ammonia, and sodium bicarbonate solutions are suitable for this purpose. The free base forms differ from their respective salt forms somewhat in certain physical properties such as solubility in polar solvents, but the salts are otherwise equivalent to their respective free base forms for purposes of the invention. The compounds of the invention can exist in unsolvated as well as solvated forms, including hydrated forms. In general, the solvated forms, including hydrated forms and the like are equivalent to the unsolvated forms for purposes of the invention. Finally, the methods of preparation for compounds of formula I' are as generally as follows: wherein T, R₁, R₂ (except when R₂ is NR₃R₄), Y and Ar are as defined above. A methyl ketone of formula II in a solvent, such as diethyl ether, or the like is added to a mixture of pyrrolidine and acetic acid. Then, a solution of an analog of benzaldehyde having the formula III wherein T and R₁ are as defined above and R₂ is as defined above (except when R₂ is amino), in a solvent such as diethyl ether, tetrahydrofuran (THF), dimethoxyethane (DME) or the like is added dropwise and stirred at about room temperature for about 12 to 48 hours to provide a condensation product of formula I' wherein T, R₁, Y and Ar are as defined above and R₂ is as defined above except when R₂ is amino. When R₂ is amino as shown in a compound of formula IV a compound of formula I" is reduced by conventional methods using Raney Nickel to obtain the compound of formula IV wherein T, R, Y and Ar are as defined above and R₂ is amino. The following Scheme II illustrates this reduction. wherein T, R₁, Y and Ar are as defined above. Alternatively, Scheme III illustrates a specific preparation for a compound of formula VI comprising a compound of formula III as defined above and a phosphorane of the formula V wherein Y and Ar are as defined above are dissolved in a solvent such as toluene, THF, dimethylsulfoxide (DMSO) or the like and warmed to reflux for from 2 to 5 hours, preferably 3 hours. The resulting product is treated in tetrahydrofuran, ethylacetate (EtOAc), or the like with an excess of sodium bisulfite dissolved in water. The treatment is at 0° to 25°C preferably 25°C for about 1 to 3 hours preferably about one hour. The phosphorane of formula V is prepared in a manner analogous to that described by Le Carre: C. R. Acad. Sci. Paris , 273 , 81 (1971). This alternative process is shown in Scheme III as follows: wherein T, R₁, Y and Ar are as defined above and R₂ is as defined above except R₂ is not the amino group. Finally, the compounds of formula VII are prepared as shown in the following Scheme IV in which a compound of formula I', IV or VI having the definitions noted above are dissolved in a solvent such as methanol, ethanol, iso-propanol or the like. Hydroxyamine and sodium acetate are added to the solution and the resulting solution stirred for two hours at about room temperature giving the compound of formula VII. wherein T, R₁, R₂, Y and Ar are as defined above. Compounds wherein X is (CH₂) n can be prepared using appropriate alkenylene containing compounds of formula I which are then hydrogenated by conventional methods. One of skill in the art would recognize variations in the sequence which may be appropriately used in the processes to make the compounds of formula I herein. Under certain circumstances it is necessary to protect either the N or O of intermediates in the above noted process with suitable protecting groups which are known. Introduction and removal of such suitable oxygen and nitrogen protecting groups are well-known in the art of organic chemistry; see for example "Protective Groups in Organic Chemistry," J. F. W. McOmie, ed., (New York, 1973), pages 43ff, 95ff, J. F. W. McOmie, Advances in Organic Chemistry , Vol. 3, 191-281 (1963); R. A. Borssonas, Advances in Organic Chemistry , Vol. 3, 159-190 (1963); and J. F. W. McOmie, Chem. & Ind. , 603 (1979). Examples of suitable oxygen protecting groups are benzyl, t-butyldimethylsilyl, ethoxyethyl, and the like. Protection of an N-H containing moiety is necessary for some of the processes described herein for the preparation of compounds of this invention. Suitable nitrogen protecting groups are benzyl, triphenylmethyl, trialkylsilyl, trichloroethylcarbamate, trichloroethoxycarbonyl, vinyloxycarbamate, and the like. Under certain circumstances it is necessary to protect two different oxygens with dissimilar protecting groups such that one can be selectively removed while leaving the other in place. The benzyl and t-butyldimethylsilyl groups are used in this way; either is removable in the presence of the other, benzyl being removed by catalytic hydrogenolysis, and t-butyldimethylsilyl being removed by reaction with, for example, tetra-n-butylammonium fluoride. In the process described herein for the preparation of compounds of this invention the requirements for protective groups are generally well recognized by one skilled in the art of organic chemistry, and accordingly the use of appropriate protecting groups is necessarily implied by the processes of the charts herein, although not expressly illustrated. The products of the reactions described herein are isolated by conventional means such as extraction, distillation, chromatography, and the like. The salts of compounds of formula I described above are prepared by reacting the appropriate base or acid with a stoichiometric equivalent of the compounds of formula I, respectively, to obtain pharmaceutically acceptable salts thereof. DESCRIPTION OF THE PREFERRED EMBODIMENTS The invention is further elaborated by the representative examples as follows. Such examples are not meant to be limiting. EXAMPLE 1. 1-(3-Hydroxy-4-methoxyphenyl)-7-phenyl-1-hepten-3-one . Pyrrolidine (2.42 g, 34.0 mMol) is added to acetic acid (2.04 g, 34.0 mMol), and the mixture is stirred at room temperature for 20 minutes. After this time, 6-phenyl-2-hexanone (4.00 g, 22.6 mMol) as a solution in diethyl ether (20 ml) is added, and the mixture is allowed to stir for an additional 15 minutes. An ethereal solution of iso-vanillin (3.45 g, 22.5 mMol) is then added dropwise. The reaction mixture is stirred for 48 hours. HCl (1.0 N, 30 ml) is then added to the reaction mixture, and the contents stirred for 20 minutes. The mixture is then taken up into an equal volume of ethyl acetate, and the phases separated. The organic layer is washed with saturated aqueous sodium bicarbonate, dried (sodium sulfate), and concentrated. The residue is chromatographed (silica gel; hexane/ethyl acetate 3:1) to afford 1.0 g (28%) of 1-(3-hydroxy-4-methoxyphenyl)-7-phenyl-1-hepten-3-one, mp = 70-75°C. C, H analysis: Calcd. for C₂₀H₂₂O₃ (77.39, 7.14); Found (77.68, 6.94). The procedure of Example 1 is within that described in the above cited reference by Itokawa H. et al in the Chem. Pharm. Bull. Similarly prepared are Examples 2-12 using the procedure of Example 1. EXAMPLE 13. 1-Penten-3-one, 1,5-bis(4-hydroxy-3-methoxyphenyl)-. 1,5-bis(4-hydroxy-3-methoxyphenyl)-1-penten-3-one is prepared according to the procedure of Example 1 from vanillin and 3-methoxy-4-hydroxybenzylacetone in 45% yield. C, H analysis: Calcd for C₁₉H₂₀O₅ (69.50, 6.13); Found (69.52, 6.15). EXAMPLE 14. 1-(4-Hydroxy-3-methoxyphenyl)-6-phenoxyl-1-hexene-3-one . According to the procedure of Example 1, 1-(4-hydroxy-3-methoxyphenyl)-6-phenoxy-1-hexene-3-one is prepared from vanillin and 5-phenoxy-2-pentanone in 40% yield, mp = 67-70°C. C, H analysis: Calcd for C₁₉H₂₀O₄·0.1H₂O (72.67, 6.50); Found (72.48, 6.49). EXAMPLE 15. [1-Pentene-3-one, 1-(3-amino-4-hydroxyphenyl)-5-phenyl]. 1-Pentene-3-one, 1-(4-hydroxy-3-nitrophenyl)-5-phenyl (3.0 g, 1.0x10⁻² moles) is reduced to the product in THF (100 ml) in the presence of Raney Nickel (0.2 g) under a pressure of 15 psi. The crude reaction mixture is evaporated to dryness and chromatographed on a flash column using hexane:ethyl acetate 3:1 to give 2.6 g of 1-pentene-3-one, 1-(3-amino-4-hydroxyphenyl)-5-phenyl (99% yield), mp = 154-158°C. C, H, N analysis calculated with 0.2 m H₂O C, H, N (75.36, 6.47, 5.19); C, H, N Found (75.36, 6.56, 5.19). EXAMPLE 16. 1-(4'-Hydroxy-3'-methoxyphenyl)-4-phenoxy-1-butene-3-one . 4-Hydroxy-3-methoxybenzaldehyde (2.1 g, 13.8 mMol) and 3-phenoxypropane-2-one triphenylphosphorane (2.8 g, 6.9 mMol) (prepared as described by LeCorre: C. R. Acad. Sci. Paris , 273 81 (1971)) are dissolved in 100 ml of toluene and warmed to reflux. After 3 hours, the solvent is evaporated and the residue is taken up in tHF. Sodium bisulfite (10.0 g) is dissolved in 100 ml of water and stirred with the solution for one hour. The THF is evaporated and the water is extracted with chloroform. Drying over magnesium sulfate and evaporation of the chloroform gives a yellow oil. Flash chromatography in ethyl acetate on silica gel gives 1.5 g (65%) of 1-(4'-hydroxy,3'-methoxyphenyl)-4-phenoxy-1-butene-3-one; mp = 85-87°C. C, H analysis: Calcd for C₁₇H₁₆O₄ (71.81, 5.68); Found (71.85, 5.50). EXAMPLE 16A. 2-Oxo-3-(phenylthio)propylidene triphenylphosphorane . Prepared by the method of Banerjee (Prostaglandins, 22 , 167-182 (1981)). Yield = 50%; mp = 133-135°C. 1-(4-Hydroxy-3-methoxyphenyl)-4-phenylthio-1-butene-3-one . Prepared by the method of Example 16. Flash chromatography in methylene chloride gives 1.3 g (62%) of 1-(4-hydroxy-3-methoxyphenyl)-4-phenylthio-1-butene-3-one; mp = 78-80°C. Analysis for C₁₇H₁₆O₃S requires C-67.97, H-5.38. Found: C-67.88, H-5.31. EXAMPLE 17. 1-Hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl, oxime . 1-Hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl (Ref. H. Itokawa, Chem. Pharm. Bull. , 31 , 2491 (1983) and as prepared in Example 1 above) (1.50 g, 4.80 mMol) is dissolved in methanol (130 ml) and stirred with hydroxylamine·HCl (2.0 g, 29.0 mMol) and sodium acetate (2.40 g, 29.0 mMol) for 2 hours at room temperature. The mixture is then evaported to dryness, redissolved in ethyl acetate (100 ml), and washed with water. The organic layer is then dried (sodium sulfate) and concentrated. Chromatography (silica gel, hexane:ethyl acetate, 3:1) affords a quantitative yield of 1-hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-, oxime; mp = 115-118°C. C, H, N analysis: Calcd for C₂₀H₃₃NO₃ (73.82, 7.12, 4.30); Found (74.04, 7.12, 4.39). Following the procedure of Example 17, and using the appropriate starting materials as prepared above or as prepared by analogous methods, the following oximes of Table 2 are prepared. EXAMPLE 24. 1-(4-Hydroxy-3-methoxyphenyl)-4-phenoxy-1-buten-3-one oxime . Following the procedure of Example 17, 1-(4-hydroxy-3-methoxyphenyl)-4-phenoxy-1-buten-3-one oxime is prepared in 39% yield; mp = 155-158°C. C, H, N analysis: Calcd for C₁₇R₁₇NO₄ (68.20, 5.74, 4.68); Found (68.26, 6.02, 4.92). EXAMPLE 24A. 1-(4-Hydroxy-3-methoxyphenyl)-4-phenylthio-1-buten-3-one oxime . Following the procedure of Example 17, (1-(4-hydroxy-3-methoxyphenyl)-4-phenylthio-1-butene-3-one omime is prepared in 28% yield; mp = 90-100°C. C, H, N analysis: Calcd for C₁₇H₁₇NO₃S (64.73, 5.44, 4.44); Found (64.44, 5.48, 4.37). EXAMPLE 25. 1-(4-Hydroxy-3-methoxyphenyl)-6-phenoxy-1-hexen-3-one oxime . Following the procedure of Example 17, 1-(4-hydroxy-3-methoxyphenyl)-6-phenoxy-1-hexen-3-one is prepared in 76% yield. C, H, N analysis: Calcd for C₁₉H₂₁NO₄·H₂O (66.06, 6.72, 4.06); Found (66.28, 6.80, 4.39). EXAMPLE 26. 1-(4-Hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-one, 0-methyl oxime . A mixture of 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-one (0.50 g, 1.61 mMol), methoxylamine·HCl (0.403 g, 4.83 mMol), and sodium acetate (0.396 g, 4.83 mMol) is stirred in methanol (10 ml) at room temperature for 12 hours. The mixture is then concentrated and taken up into chloroform. The organic layer is washed with water and brine, and then dried (sodium sulfate). Concentration gives pure 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-1-hepten-3-one, O-methyl oxime (490 mg) as a semi-solid. EXAMPLE 27. 1-(3-Methoxy-4-hydroxyphenyl)-5-(2-furyl)-1-penten-3-one . Using the method of Example 1 using 1-(2-furyl)-3-butanone bp 75-78°C at 10 mm Hg (prepared by the method analogous to Yamashita, Tet. Let. , 1975, p. 1867 with a yield of 47%) the 1-(3-methoxy-4-hydroxyphenyl)-5-(2-furyl)-1-pentene-3-one is prepared in 49% yield. mp = 82-84°C. C, H, N analysis: Calcd for C₁₆R₁₆O₄ (70.56, 5.93); Found (70.50), 6.14). EXAMPLE 28. 1-(3-Methoxy-4-hydroxyphenyl)-5-(2-furyl)-1-penten-3-one oxime . Using the procedure of Example 17, 1-(3-methoxy-4-hydroxyphenyl)-5-(2-furyl)-1-pentene-3-one oxime is prepared in 61% yield; mp = 110-120°C. C, H, N analysis: Calcd for C₁₆H₁₇NO₄ (66.88, 5.98, 4.88); Found (66.57, 6.03, 4.80). EXAMPLE 29. α-((4-Hydroxy-3,5-dimethoxyphenyl)methylidine)-β-oxo-5-(2-furan)pentanoic acid, ethyl ester . A mixture of ethyl 5-(2-furanyl)-3-oxopentanoate (157.48 g, 0.75 mol), syringic aldehyde (91.0 g, 0.5 mol), 4-methyl piperidine (4.0 g, 0.04 mol), and benzoic acid (0.97 g, 0.0078 mol) in toluene (600 ml) is heated to reflux under nitrogen for 24 hours with a water separator. The mixture is cooled, diluted with ether (1.0 L) and washed successively with 5% HCl, water, NaHCO₃ solution, water, 5% acetic acid and water and then dried (Na₂SO₄). The solvent is removed under reduced pressure and the crude oil (212 g) is chromatographed over silica gel. Elution with methylene chloride gives the crude product as solid which is recrystallized from ether. Yield 70.7 g (37.8%), mp 103-104°C. EXAMPLES 30 AND 31. The procedure described in Example 29 is repeated to prepare the following α-((4-hydroxy-3,5-disubstituted phenyl)methylidine-β-oxo-pentanoic acid, ethyl esters, starting from appropriately substituted 4-hydroxy-benzaldehyde and ethyl 5-(aryl)-3-oxo-pentanoate in presence of piperidine or methyl piperidine as base in each case: EXAMPLE 30. α-[(4-Hydroxy-3,5-di-tert-butylphenyl)methylidine]-β-oxo-5-(2-furan)pentanoic acid, ethyl ester . Mp 80-2°C. EXAMPLE 31. α-[(4-Hydroxy-3,5-dimethoxyphenyl)methylidine]-β-oxo-5-phenylpentanoic acid, ethyl ester . Mp 109.5-111.5°C starting from ethyl 5-phenyl-3-oxo-pentanoate and syringic aldehyde. EXAMPLE 32. α-[(4-Hydroxy-3,5-dimethoxyphenyl)methylidine]-β-oxo-5-(2-furan)pentanoic acid . A mixture of ethyl α-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-β-oxo-5-(2-furan)pentanoate (20 g, 0.053 mol) and aqueous methanolic potassium hydroxide solution [prepared from potassium hydroxide (10.6 g), water (75 ml) and methanol (125 ml)] is heated to reflux on a steam bath for 3.0 hours. Methanol is removed under reduced pressure and the residue is diluted with water (450 ml), extracted with ether and then acidified with 4 N HCl. The acidic material is extracted with ethyl acetate as usual to give 6.35 g (34%) of the acid, mp 135°C (dec). It is recrystallized from ethyl acetate to give an analytical sample, mp 135°C (dec). EXAMPLE 33. (E)1-[(3,5-Dimethoxy-4-hydroxy)phenyl]-5-(2-furanyl)-1-penten-3-one . 4-(2-Furanyl)-2-butanone (7.8 g, 0.056 mol) is added to a solution of pyrrolidine (7.1 g, 0.1 mol) in acetic acid (6.0 g, 0.1 mol) and the mixture is stirred at 23°C for 28 min. A solution of syringic aldehyde (9.8 g, 0.054 mol) in THF (70 ml) is then added dropwise and the mixture is stirred for 72 hours. The reaction mixture is added to 5% HCl and the contents are stirred for 3.0 hours. The product is extracted with ethyl acetate, dried and concentrated to give 4.95 g of residue. This is chromatographed over silica gel and eluted with CHCl₃-CH₃OH (95:5) mixture to give a solid which is recrystallized from isopropyl ether. Yield 1.4 g (9%), mp 107-9°C. EXAMPLE 34. (E)4-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)-1-phenoxy-3-buten-2-one A solution of 3,5-di-t-butyl-4-hydroxy benzaldehyde (3.75 g, 0.016 mol) and 1-phenoxy-3-(triphenylphosphoranylidene)-2-propanone (Wittig reagent) (9.85 g, 0.024 mol) in xylene (200 ml) is heated under reflux for 6 hours in a nitrogen atmosphere. An additional amount (6.6 g; 0.016 mol) of Wittig reagent is added and refluxing continued for 6 more hours. The dark brown reaction mixture is filtered through silica gel 60 (60 g) and then chromatographed over silica gel eluting with 1:2-EtOAc-cyclohexane. The dark-brown fractions containing product are treated with charcoal and then rechromatographed on a flash chromatography column (75 g silica gel 60, 230-400 mesh) eluting with 10% EtOAc-cyclohexane. The isolated pure product is recrystallized from pentane as golden tan crystals (1.31 g, 22%), mp 100-101.5°C. EXAMPLES 35-39. The procedure described in Example 34 is repeated to prepare the following 4-[(substituted-4-hydroxyphenyl)-1-phenoxy ( or substituted phenoxy)]-3-buten-2-ones, starting from appropriately substituted-4-hydroxybenzaldehyde and appropriate Wittig reagents in each case. Example T and R₁ Ar Solvent mp 35 3,5-(OCH₃)₂ phenyl toluene 149-150°C 36 3,5-(iso-Pr)₂ phenyl toluene 117-119.5°C 37 3,5-(t-ßu)₂ 4-(CH₂COOCH₃)phenyl xylene 101.5-103°C 38 3,5-(OCH₃)₂ 4-(CH₂COOCH₃)phenyl toluene 116.5-119.5°C 39 3-OCH₃ 4-(CH₂COOCH₃)phenyl toluene 97-98°C EXAMPLE 40. (Intermediate Wittig Reagent) 1-Triphenylphosphoranylidene-3-(4'-methoxyacetylphenoxy)-2-propane (A compound of the formula V wherein n is 1, Y is O and Ar is phenyl having a para substituent of the formula CH₃O₂CCH₂.) A solution of methyl 4-hydroxyphenyl acetate (40 g, 0.24 mol) in dry THF (300 ml) is added to a cold (0-5°C) suspension of NaH (10 g, 60% oil dispersion, 0.25 mol) in THF (150 ml) over 45 min. After the addition is complete, the mixture is stirred at 23°C for 1.5 hours. 1-Chloro-3-triphenyl phosphoranylidene)-2-propanone (77.6 g; 0.22 mol) is added in one lot to the anion and then refluxed for 5.0 hours. The reaction mixture is cooled, decomposed with acetic acid (10 ml) and then evaporated to dryness. The residue is suspended in 0.33 N HCl (300 ml) and then extracted with CH₂Cl₂. The organic layer is washed with saturated NaHCO₃ solution, dried (MgSO₄) and evaporated to dryness. The crude product of formula V having n, Y and Ar as defined above is recrystallized from EtOAc as white crystals. Yield 73.5 g (63.5%), mp 143.5-145.5°C. EXAMPLE 41. (E)-1-[(3,5-Dimethoxy-4-hydroxy)phenyl]-4-phenoxy-1-buten-3-one oxime A solution of ( E )-4-(4-hydroxy-3,5-dimethoxyphenyl)-1-phenoxy-3-buten-2-one (0.95 g, 0.003 mol) and hydroxylamine hydrochloride (0.42 g, 0.006 mol) in 1:1-pyridine-ethanol (10 ml) is heated under reflux for 2.0 hours. The reaction mixture is evaporated to near dryness and then suspended in water (50 ml) and extracted with ether. The ether extracts are evaporated to dryness and the residue is chromatographed over silica gel 60 (30 g) eluting with EtOAc-toluene (1:2). The purified product is recrystallized from Et₂O. Yield 0.29 g (29.4%), mp 144-147°C. The usefulness of the compounds of the present invention as inhibitors of lipoxygenase enzyme or other related biochemical actions is demonstrated by their effectiveness in various standard test procedures. A description of each procedure follows. 5-Lipoxygenase Assay Using Isolated Human Leukocytes (5LOA₂) The formation of 5-HETE in human leukocytes is considered a measure of 5-lipoxygenase activity. The protocol is described in the following. Fresh heparinized or EDTA treated human blood is mixed with 6% dextran-3% dextrose in isotonic saline in the ratio 0.25 ml dextran solution per 1.0 ml blood. After mixing the blood is allowed to sit at room temperature for about 90 minutes while the RBC's settle. During this period, the plasma is removed with a plastic pipette to nalgens tubes. The plasma is centrifuged at 800 rpm (125 kg) on the Beckman Td-b refrigerated centrifuge to remove the platelets (which remain in the supernatant). The pellet, consisting of leukocytes and erythrocytes, is treated with 10 ml 0.87% ammonium chloride at room temperature for four mintues, lysing the red cells. At the end of four minutes the cells are diluted with a 2x volume of phosphate buffered saline, pH 7.4, and centrifuged for ten minutes. The cells are washed three times with the phosphate buffered saline. Any of the pelleted cell matter which is not easily resuspended is discarded during the washings--the material contains platelets (12-lipoxygenase activity). After washing, the cells are resuspended in phosphate buffered saline containing 1.0 mM calcium and 0.5 mM magnesium. After counting, the cells are diluted to 1.5-2.0 x 10⁻⁷ leukocytes per milliliter. To each poly propylene reaction tube is added 0.48 ml leukocytes in Ca-Mg phosphate buffered saline, pH 7.4; 1-5 µl test compound dissolved in DMSO and buffer; or DMSO for control tubes. The tubes preincubate at 37°C for five minutes. The reaction is started by adding 20 µl of the following, 0.5 µl, 20 mM arachidonic acid--final concentration = 20 µm; 1 µl, 5 mM calcium ionophore A23187--final concentration = 10 µm; and 18.5 µl buffer. The reaction proceeds for five minutes, then is stopped by adding 0.5 ml, 0.5 mM ice cold Tris buffer, pH 8.0. The tubes are chilled on ice for ten minutes and then extracted three times with a total of 3.5 ml ethyl acetate (3.0 ml removed). The tubes can be stored at this point. For extended storage, the tubes should be filled with nitrogen. The ethyl acetate is evaporated with a Sorvall Speed-Vac. The residue is dissolved in ethanol. The tubes can also be stored at this point at -20°C under nitrogen. A portion of the ethanol solution is injected into the HPLC system for 5-HETE quantitation. The HPLC system consists of Hewlett-Packard 1040A UV spectrophotometry system with an HP85 computer. Injections are made automatically with a Waters WISP 710B. The pump is a Spectra Physics SP8700. Peaks are measured with a Hewlett Packard 3390A integrator. An RP C-18 column is used. The solvent system is isocratic; the solvent is 70% methanol and 30% 0.01M sodium acetate, pH 5.7, pumped at 1.0 ml/min. The flow is monitored at 235 nm for 5-HETE quantitation. Using a 15 cm Alltech Nucleosil C-18 5 µM column provides for a sample turnaround time of about 16 minutes. IC₅₀ is calculated as the amount of test agent that causes 50% inhibition of the formation of 5-HETE relative to the control. Cyclooxygenase Enzyme Assay (BSV) Additionally, inhibition of cyclooxygenase is considered a measure of relevance to the pathophysiology for the above noted diseases. For example, see "Inhibition of Immunoglobulin E-Mediate, Antigen-Induced Monkey Asthma and Skin Reactions by 5,8,11,14-Eicosatetraynoic Acid," by Roy Patterson, M.D. and Kathleen E. Harris, B.S. in J. Allergy Clin. Immunol. , vol. 67, no. 2, pp. 146-152. The assay consists of incubating 2 mg bovine seminal vesicle powder with 2 mM epinephrine, 2.5 mM reduced glutathione, 100 µM arachidonic acid, and the test agent for 20 minutes. The reaction mixture is acidified and extracted with ethyl acetate (3 x 1.0 ml) and the pooled extract is evaporated to dryness using a Speed Vac Concentrator or under a stream of nitrogen. The residue is dissolved in ethanol. An aliquot is applied on 20 x 20 cm silica gel plate and developed using water: ethyl acetate:hexane:acetic acid (60:54:25:12.5, upper phase) to separate PGE₂ from arachidonic acid. ¹⁴C-PGE₂ formed is identified by co-chromatography with authentic ³H-PGE₂ and the amount of radioactivity is quantitated using an automatic TLC linear scanner (Berthold, Pittsburgh, Pennsylvania) linked to an Apple II-e computer and an IC₅₀ is calculated as the amount of test agent causing 50% inhibition of Cyclooxygenase Enzyme relative to the control. The above defined value for each of tested compounds of the present invention having the noted example numbers are as found in the following Table 3. Example No. 5-LOA IC₅₀ (µM) BSV IC₅₀ (µM) 17 1.7 23.0 18 5.9 19 1.0 125.0 20 8.7 21 0.420 33.0 22 35.0 23 (Isomer A) 0.165 98.0 23 (Isomer B) 0.26 90.0 24 2.5 57.0 25 0.71 170.0 26 3.0 Accordingly, the present invention also includes a pharmaceutical composition for treating one of the above diseases or conditions comprising an antidisease or anticondition effective amount of a compound of the formula I as defined above together with a pharmaceutically acceptable carrier. The present invention further includes the use of compounds I for the manufacture of a medicament for treating one of the above named diseases or conditions in mammals, including man, suffering therefrom comprising administering to such mammals either orally or parenterally, preferably oral, a corresponding pharmaceutical composition containing a compound of formula I as defined above in appropriate unit dosage form. For preparing pharmaceutical compositions from the compounds described by this invention, inert, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets, and suppositories. A solid carrier can be one or more substances which may also act as diluents, flavoring agents, solubilizers, lubricants, suspending agents, binders or tablet disintegrating agents; it can also be encapsulating material. In powders, the carrier is a finely divided solid which is in admixture with the finely divided active compound. In the tablet the active compound is mixed with carrier having the necessary binding properties in suitable proportions and compacted in the shape and size desired. The powders and tablets preferably contain from 5 or 10 to about 70 percent of the active ingredient. Suitable solid carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier providing a capsule in which the active component (with or without other carriers) is surrounded by carrier, which is thus in association with it. Similarly, cachets are included. Tablets, powders, cachets, and capsules can be used as solid dosage forms suitable for oral administration. For preparing suppositories, a low melting wax such as a mixture of fatty acid glycerides or cocoa butter is first melted, and the active ingredient is dispersed homogeneously therein as by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool and thereby to solidify. Liquid form preparations include solutions, suspensions, and emulsions. As an example may be mentioned water or water-propylene glycol solutions for parenteral injection. Liquid preparations can also be formulated in solution in aqueous polyethylene glycol solution. Aqueous solutions suitable for oral use can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizing and thickening agents as desired. Aqueous suspensions suitable for oral use can be made by dispersing the finely divided active component in water with viscous material, i.e., natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well-known suspending agents. Also included are solid form preparations which are intended to be converted, shortly before use, to liquid form preparations for either oral or parenteral administration. Such liquid forms include solutions, suspensions, and emulsions. These particular solid form preparations are most conveniently provided in unit dose form and as such are used to provide a single liquid dosage unit. Alternately, sufficient solid may be provided so that after conversion to liquid form, multiple individual liquid doses may be obtained by measuring predetermined volumes of the liquid form preparation as with a syringe, teaspoon, or other volumetric container. When multiple liquid doses are so prepared, it is preferred to maintain the unused portion of said liquid doses at low temperature (i.e., under refrigeration) in order to retard possible decomposition. The solid form preparations intended to be converted to liquid form may contain, in addition to the active material, flavorants, colorants, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. The liquid utilized for preparing the liquid form preparation may be water, isotonic water, ethanol, glycerine, propylene glycol, and the like as well as mixtures thereof. Naturally, the liquid utilized will be chosen with regard to the route of administration, for example, liquid preparations containing large amounts of ethanol are not suitable for parenteral use. Preferably, the pharmaceutical preparation is in unit dosage form. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, for example, packeted tablets, capsules, and powders in vials or ampules. The unit dosage form can also be a capsule, cachet, or tablet itself or it can be the appropriate number of any of these in packaged form. The quantity of active compound in a unit dose of preparation may be varied or adjusted from 1 mg to 500 mg preferably to 1 to 50 mg according to the particular application and the potency of the active ingredient. The compositions can, if desired, also contain other compatible therapeutic agents. In therapeutic use as described above, the dosages may be varied depending upon the requirements of the patient, the severity of the condition being treated, and the compound being employed. Determination of the proper dosage for a particular situation is within the skill of the art. Generally, treatment is initiated with the smaller dosages which are less than the optimum dose of the compound. Thereafter the dosage is increased by small increments until the optimum effect under the circumstances is reached. For convenience, the total daily dosage may be divided and administered in portions during the day if desired. As used herein cardiovascular diseases or conditions particularly include 1) reductions of the extent of infarct damage in a myocardial infarction, 2) prevention of recurrent myocardial infarction, 3) stroke, 4) anaphylactic shock, and 5) vasospastic disease. An additional advantageous benefit of the cytoprotective property of the compounds of formula I are for use, for example, to protect against damage from various GI tract conditions. Generally accepted assays can be used to measure cytoprotective activity. The magnitude of a prophylactic or therapeutic dose of a compound of formula I will, of course, vary with the nature of the severity of the condition to be treated and with the particular compound of formula I and its route of administration. In general, the daily dose range for anti-asthmatic, anti-allergic or anti-inflammatory use and, generally uses other than cytoprotection, lies within the range of from about 10 µg to about 20 mg per kg body weight of a mammal, preferably from about 50 µg to about 20 mg per kg of body weight of a mammal, and most preferably from about 100 µg to about 10 mg per kg of body weight of a mammal. The exact amount of a compound of the formula I to be used as a cytoprotective agent will depend on, inter alia , whether it is being administered to heal damaged cells or to avoid future damage, on the nature of the damaged cells (e.g., gastro-intestinal ulcerations vs. nephrotic necrosis), and on the nature of the causative agent. An example of the use of a compound of the formula I in avoiding future damage would be co-administration of a compound of the formula I with a non-steroidal anti-inflammatory drug (for example, indomethacin) that might otherwise cause such damage. For such use, the compound of formula I is administered from 30 minutes prior up to 30 minutes after administration of the NSAID. Preferably, it is administered prior to or simultaneously with the NSAID (e.g. as a combination dosage form). The effective daily dosage level for compounds of formula I inducing cytoprotection in mammals, especially humans, will generally range from about 0.002 mg/kg to about 100 mg/kg, preferably from about 0.02 mg/kg to about 30 mg/kg. The dosage may be administered in single or divided individual doses. Thus, in addition to the compounds of formula I, the pharmaceutical compositions can also contain other active ingredients, such as cyclooxygenase inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), peripheral analgesic agents such as zomepirac, diflunisal and the like. The weight ratio of the compound of the formula I to the second active ingredient may be varied and will depend upon the effective dose of each ingredient. Generally, an effective dose of each will be used. Thus, for example, when a compound of the formula I is combined with an NSAID, the weight ratio of the compound of the formula I to the NSAID will generally range from about 1000:1 to about 1:1000, preferably about 200:1 to about 1:200. Combinations of a compound of the formula I and other active ingredients will generally also be within the aforementioned range, but in each case, an effective dose of each active ingredient should be used. Combinations of a compound of the formula I and other active ingredients will generally be in the aforementioned ratios. NSAIDs can be characterized into five groups: (1) the propionic acid derivatives; (2) the acetic acid derivatives; (3) the fenamic acid derivatives; (4) the biphenylcarboxylic acid derivatives; and (5) the oxicams or a pharmaceutically acceptable salt thereof. The propionic acid derivatives which may be used comprise: ibuprofen, ibuprofen aluminum, indoprofen, ketoprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid. Structurally related propionic acid derivatives having similar analgesic and anti-inflammatory properties are also intended to be included in this group. Thus, "propionic acid derivatives" as defined herein are non-narcotic analgesics/non-steroidal anti-inflammatory drugs having a free -CH(CH₃)COOH or -CH₂CH₂COOH group (which optionally can be in the form of a pharmaceutically acceptable salt group, e.g., -CH(CH₃)COO⁻Na⁺ or -CH₂CH₂COO⁻Na⁺), typically attached directly or via a carbonyl function to a ring system, preferably to an aromatic ring system. The acetic acid derivatives which may be used comprise: indomethacin, which is a preferred NSAID, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxpinac, and fenclozic acid. Structurally related acetic acid derivatives having similar analgesic and antiinflammatory properties are also intended to be encompassed by this group. Thus, "acetic acid derivatives" as defined herein are non-narcotic analgesics/non-steroidal anti-inflammatory drugs having a free -CH₂COOH group (which optionally can be in the form of a pharmaceutically acceptable salt group, e.g. -CH₂COO⁻Na⁺), typically attached directly to a ring system, preferably to an aromatic or heteroaromatic ring system. The fenamic acid derivatives which may be used comprise: mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid and tolfenamic acid. Structurally related fenamic acid derivatives having similar analgesic and anti-inflammatory properties are also intended to be encompassed by this group. Thus, "fenamic acid derivatives" as defined herein are non-narcotic analgesics/non-steroidal anti-inflammatory drugs which contain the basic structure: which can bear a variety of substituents and in which the free -COOH group can be in the form of a pharmaceutically acceptable salt group, e.g., -COO⁻Na⁺. The biphenylcarboxylic acid derivatives which can be used comprise: diflunisal and flufenisal. Structurally related biphenylcarboxylic acid derivatives having similar analgesic and anti-inflammatory properties are also intended to be encompassed by this group. Thus, "biphenylcarboxylic acid derivatives" as defined herein are non-narcotic analgesics/non-steroidal anti-inflammatory drugs which contain the basic structure: which can bear a variety of substituents and in which the free -COOH group can be in the form of a pharmaceutically acceptable salt group, e.g., -COO⁻Na⁺. The oxicams which can be used in the present invention comprise: piroxicam, sudoxicam, isoxicam and 4-hydroxyl-1,2-benzothiazine 1,1-dioxide 4-(N-phenyl)-carboxamide. Structurally related oxicams having similar analgesic and anti-inflammatory properties are also intended to be encompassed by this group. Thus, "oxicams" as defined herein are non-narcotic analgesics/non-steroidal anti-inflammatory drugs which have the general formula: wherein R is an aryl or heteroaryl ring system. The following NSAIDs may also be used: acemetacin, alminoprofen, amfenac sodium, aminoprofen, anitrazafen, antrafenine, auranofin, bendazac lysinate, benzydamine, beprozin, broperamole, bufezolac, carprofen, cinmetacin, ciproquazone, clidanac, cloximate, dazidamine, deboxamet, delmetacin, detomidine, dexindoprofen, diacerein, di-fisalamine, difenpyramide, emorfazone, enfenamic acid, enolicam, epirizole, etersalate, etodolac, etofenamate, fanetizole mesylate, fenclofenac, fenclorac, fendosal, fenflumizole, fentiazac, feprazone, floctafenine, flunixin, flunoxaprofen, fluproquazone, fopirtoline, fosfosal, furcloprofen, furofenac, glucametacin, guaimesal, ibuproxam, isofezolac, isonixim, isoprofen, isoxepac, isoxicam, lefetamine HCl, leflunomide, lofemizole, lonazolac calcium, lotifazole, loxoprofen, lysin clonixinate, meclofenamate sodium, meseclazone, microprofen, nabumetone, nictindole, nimesulide, orpanoxin, oxametacin, oxapadol, oxaprozin, perisoxal citrate, pimeprofen, pimetacin, piproxen, pirazolac, pirfenidone, pirprofen, pranoprofen, proglumetacin maleate, proquazone, pyridoxiprofen, sudoxicam, suprofen, talmetacin, talniflumate, tenoxicam, thiazolinobutazone, thielavin B, tiaprofenic acid, tiaramide HCl, tiflamizole, timegadine, tioxaprofen, tolfenamic acid, tolpadol, tryptamid, ufenamate, and zidometacin. Finally, NSAIDs which may also be used include the salicylates, specifically aspirin, and the phenylbutazones, and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising the formula I compounds may also contain as the second active ingredient, antihistaminic agents such as benadryl, dramamine, histadyl, phenergan and the like. Alternatively, they may include prostaglandin antagonists such as those disclosed in European Patent Application 11,067 or thromboxane antagonists such as those disclosed in U.S. 4,237,160. They may also contain histidine decarboxylase inhibitors such as α-fluoromethylhistidine, described in U.S. 4,325,961. The compounds of the formula I may also be advantageously combined with an H₁ or H₂-receptor antagonist, such as for instance cimetidine, ranitidine, terfenadine, famotidine, aminothiadiazoles disclosed in EP 81102976.8 or temelastine, acrivastine, loratadine, cetrizine, tazifylline, azelastine and like compounds, such as those disclosed in U.S. Patent Nos. 4,283,408; 4,362,736; 4,394,508 and European Patent Application No. 40,696. The pharmaceutical compositions may also contain a K⁺/H⁺ ATPase inhibitor such as omeprazole, disclosed in U.S. Pat. 4,255,431, and the like. Each of the references referred to in this paragraph is hereby incorporated herein by reference.

Claims: A compound of the formula or a pharmaceutically acceptable addition salt thereof, wherein (a) R₁ is (i) hydroxy, (ii) lower alkoxy, (iii) COOR₃ wherein R₃ is hydrogen or lower alkyl, (iv) lower alkanoyl, (v) NR₃R₄ wherein R₃ and R₄ are independently hydrogen or lower alkyl, (vi) wherein R₃ is independently as defined above, (vii) wherein R₃ is independently as defined above, (viii) wherein R₃ is independently as defined above, or (ix) wherein R₃ is independently as defined above; (b) R₂ is (i) hydroxy, (ii) lower alkoxy, (iii) lower thioalkoxy, (iv) lower alkanoyl, (v) halogen, (vi) trifluoromethyl, (vii) hydroxymethyl, (viii) lower alkyl, (ix) NR₃R₄ wherein R₃ and R₄ are independently hydrogen or lower alkyl, (x) nitro, (xi) wherein R₃ is independently as defined above, (xii) wherein R₃ is independently as defined above, (xiii) wherein R₃ is independently as defined above, (xiv) wherein R₃ is independently as defined above, or (xv) wherein R₃ is independently as defined above; (c) T is (i) hydrogen, (ii) lower alkyl, (iii) hydroxy, (iv) lower alkanoyl, (v) NR₃R₄ wherein R₃ and R₄ are independently as defined above, (vi) nitro, (vii) halogen, (viii) trifluoromethyl, (ix) lower alkoxy, (x) lower thioalkoxy, (xi) wherein R₃ is independently as defined above, (xii) wherein R₃ is independently as defined above, or (xiii) wherein R₃ is independently as defined above, (xiv) wherein R₃ is as defined above; (d) X and Y are independently (i) (CH₂) n , (ii) CH=CH, (iii) (CH₂) n M, wherein n is an integer of one to four and M is oxygen, NR₃ wherein R₃ is independently as defined above, or S(O)g wherein g is zero, one or two or (iv) -CH=C(CO₂R₃) wherein R₃ is independently defined as above (e) Ar is (i) phenyl or naphthyl each of which is unsubstituted or substituted by one, two or three substituents comprising one or more of each of lower alkyl, hydroxy, lower alkoxy, lower thioalkoxy, lower alkanoyl, halogen, trifluoromethyl, lower carboalkoxy, hydroxymethyl, NR₃R₄ wherein R₃ and R₄ are independently as defined above, nitro, COR₃ wherein R₃ is independently as defined above, or wherein R₃ and R₄ are independently as defined above, or (ii) a heteroaryl unsubstituted or substituted on one or two carbons by one or more of each of lower alkyl, hydroxy, lower alkoxy, lower alkanoyloxy, lower carboalkoxy, halogen, trifluoromethyl, hydroxymethyl, NR₃R₄ wherein R₃ and R₄ are independently as defined above, wherein R₃ is independently as defined above or wherein R₃ and R₄ are independently as defined above; in which the heteroaryl comprises pyrrolyl, furanyl, thiophenyl, oxazolyl, thiazolyl, imidazolyl, isothiazolyl, isoxazolyl, or pyrazolyl. A compound of Claim 1 wherein T is hydrogen. A compound of Claim 1 and 2 selected from the group consisting of ( E )-1-(4-hydroxy-3,5-dimethoxyphenyl)-4-phenoxy-1-butene-3-one, oxime; 1-hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-, oxime, (E)-; 1-hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-, O-methyloxime, (E)-; 1-hepten-3-one, 1-(3,4-dihydroxyphenyl)-7-phenyl-, oxime, (E)-; 1-hepten-3-one, 1-(3-hydroxy-4-methoxyphenyl)-7-phenyl-, oxime, (E)-; 1-penten-3-one, (1-(4-hydroxy-3-methoxyphenyl)-5-phenyl-, oxime, (E)-; 1-hepten-3-one, 1-[4-hydroxy-3-(hydroxymethyl)-phenyl]-, 7-phenyl-oxime, (E)-; 1-penten-3-one, 1-[4-hydroxy-3-(hydroxymethyl)phenyl]-5-phenyl-, oxime; 1-hexen-3-one, 1-(4-hydroxy-3-methoxyphenyl)-6-phenoxy-, oxime, (E)-; 1-penten-3-one, 1-(3-amino-4-hydroxyphenyl)-5-phenyl-, oxime, (E)-; 1-(4-hydroxy-3-methoxyphenyl)-4-phenylthio-1-buten-3-one, oxime; 3-buten-2-one, 4-(4-hydroxy-3-methoxyphenyl)-1-phenoxy-, oxime, (E)-; 1-(3-methoxy-4-hydroxyphenyl)-5-(2-furyl)-1-penten-3-one oxime . A pharmaceutical composition comprising a compound of Claims 1 to 3 and a pharmaceutically acceptable carrier. A pharmaceutical composition of Claim 4 comprising a second active ingredient that is nonsteroidal antiinflammatory drug; a peripheral analgesic agent; a cycloxygenase inhibitor; a leukotriene antagonist; an antihistaminic agent; a prostaglandin antagonist, or a thromboxane antagonist. Use of the compounds of Claims 1 to 3 for the manufacture of a medicament for treating inflammatory, allergic, asthmatic, cardiovascular, or psoriatic conditions in mammals suffering therefrom. A process for the preparation of a compound of formula I or a pharmaceutically acceptable addition salt thereof, wherein (a) R₁ is (i) hydroxy, (ii) lower alkoxy, (iii) COOR₃ wherein R₃ is hydrogen or lower alkyl, (iv) lower alkanoyl, (v) NR₃R₄ wherein R₃ and R₄ are independently hydrogen or lower alkyl, (vi) wherein R₃ is independently as defined above, (vii) wherein R₃ is independently as defined above, (viii) wherein R₃ is independently as defined above, or (ix) wherein R₃ is independently as defined above; (b) R₂ is (i) hydroxy, (ii) lower alkoxy, (iii) lower thioalkoxy, (iv) lower alkanoyl, (v) halogen, (vi) trifluoromethyl, (vii) hydroxymethyl, (viii) lower alkyl, (ix) NR₃R₄ wherein R₃ and R₄ are independently hydrogen or lower alkyl, (x) nitro, (xi) wherein R₃ is independently as defined above, (xii) wherein R₃ is independently as defined above, (xiii) wherein R₃ is independently as defined above, (xiv) wherein R₃ is independently as defined above, or (xv) wherein R₃ is independently as defined above; (c) T is (i) hydrogen, (ii) lower alkyl, (iii) hydroxy, (iv) lower alkanoyl, (v) NR₃R₄ wherein R₃ and R₄ are independently as defined above, (vi) nitro, (vii) halogen, (viii) trifluoromethyl, (ix) lower alkoxy, (x) lower thioalkoxy, (xi) wherein R₃ is independently as defined above, (xii) wherein R₃ is independently as defined above, or (xiii) wherein R₃ is independently as defined above, (xiv) wherein R₃ is as defined above; (d) X and Y are independently (i) (CH₂) n , (ii) CH=CH, (iii) (CH₂) n M, wherein n is an integer of one to four and M is oxygen, NR₃ wherein R₃ is independently as defined above, or S(O)q wherein q is zero, one or two or (iv) -CH=C(CO₂R₃) wherein R₃ is independently defined as above (e) Ar is (i) phenyl or naphthyl each of which is unsubstituted or substituted by one, two or three substituents comprising one or more of each of lower alkyl, hydroxy, lower alkoxy, lower thioalkoxy, lower alkanoyl, halogen, trifluoromethyl, lower carboalkoxy, hydroxymethyl, NR₃R₄ wherein R₃ and R₄ are independently as defined above, nitro, COR₃ wherein R₃ is independently as defined above, or wherein R₃ and R₄ are independently as defined above, or (ii) a heteroaryl unsubstituted or substituted on one or two carbons by one or more of each of lower alkyl, hydroxy, lower alkoxy, lower alkanoyloxy, lower carboalkoxy, halogen, trifluoromethyl, hydroxymethyl, NR₃R₄ wherein R₃ and R₄ are independently as defined above, wherein R₃ is independently as defined above or wherein R₃ and R₄ are independently as defined above; in which the heteroaryl comprises pyrrolyl, furanyl, thiophenyl, oxazolyl, thiazolyl, imidazolyl, isothiazolyl, isoxazolyl, or pyrazolyl which comprises reacting a compound of the formula (III) : wherein T, R₁ and R₂ are as defined above with the proviso that R₂ is not NH₂; with a compound of the formula (VIII): wherein Q is -CH₃, or CH₂CO₂lower alkyl to obtain a compound of formula: wherein W is H or CO₂ lower alkyl and n, Y, Ar, T, R₁ and R₂ are as defined above with the proviso that R₂ is not NH₂; and further, optionally, reducing with Raney Nickel the compound of formula I' wherein R₂ is NO₂ to obtain the compound of formula I' wherein R₂ is NH₂, hydrogenating the compound of formula I' to obtain a compound of the formula (I₁) wherein R₁, R₂, T, W, Y and Ar have the above meaning and reacting the compound of formula (I') or (I₁) with a hydroxylamine to obtain an oxime-compound according to formula (I). A process of claim 7 for the manufacture of a compound wherein T is hydrogen. A process of claim 7 for the manufacture of a compound selected from the group consisting of (E)-1-(4-hydroxy-3,5-dimethoxyphenyl)-4-phenoxy-1-butene-3-one, oxime; 1-hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-, oxime, (E)-; 1-hepten-3-one, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-, O-methyloxime, (E)-; 1-hepten-3-one, 1-(3,4-dihydroxyphenyl)-7-phenyl-, oxime, (E)-; 1-hepten-3-one, 1-(3-hydroxy-4-methoxyphenyl)-7-phenyl-, oxime, (E)-; 1-penten-3-one, (1-(4-hydroxy-3-methoxyphenyl)-5-phenyl-, oxime, (E)-; 1-hepten-3-one, 1-[4-hydroxy-3-(hydroxymethyl)-phenyl]-, 7-phenyl-oxime, (E)-; 1-penten-3-one, 1-[4-hydroxy-3-(hydroxymethyl)phenyl]-5-phenyl-, oxime; 1-hexen-3-one, 1-(4-hydroxy-3-methoxyphenyl)-6-phenoxy-, oxime, (E)-; 1-penten-3-one, 1-(3-amino-4-hydroxyphenyl)-5-phenyl-, oxime, (E)-; 1-(4-hydroxy-3-methoxyphenyl)-4-phenylthio-1-buten-3-one, oxime; 3-buten-2-one, 4-(4-hydroxy-3-methoxyphenyl)-1-phenoxy-, oxime, (E)-; 1-(3-methoxy-4-hydroxyphenyl)-5-(2-furyl)-1-penten-3-one oxime. Process of manufacturing a pharmaceutical composition characterized by combining a compound prepared by claims 7 to 9 with a pharmaceutically acceptable carrier.

Inventors: CONNOR, DAVID THOMAS, FLYNN, DANIEL LEE
Applicants: WARNER-LAMBERT COMPANY
Application year: 1987
Main classification: C07C251
IPC codes: C07C49, C07C45, C07D307, C07C65, C07C205, A61K31