BACTERICIDAL COMPOSITION AND USE THEREOF

Abstract: A composition comprising didecyldimethylammonium chloride and an alkylene oxide adduct of a polyhydric alcohol being trivalent or more and its use as a bacteriocide is disclosed.

Description: This invention relates to a bactericidal composition. More particularly, it relates to a bactericidal composition which exhibits a high bactericidal effect even in the presence of organic materials such as feces in a cattle stall. It has been videly known that didecyldimethylammonium chloride exhibits higher bactericidal effects on various bacteria including pathogenic ones than other bactericidal compounds such as alkylbenzyldimethylammonium chloride. However, didecyldimethylammonium chloride has the disadvantage that its bactericidal effect is significantly lowered because of a large amount of feces adhering thereto when used in stalls of cattle, for example, cows or horses, or poultry. Under these circumstances, we have tried to solve the above problem and to enhance the bactericidal effect of didecyldimethylammonium chloride in the presence of organic materials originating from feces. As a result, we have found that the didecyldimentylammonium chloride can exhibit an excellent bactericidal effect even in the presence of organic materials when used together with a particular compound, thus completing the present invention. The invention provides a bactericidal composition which comprises didecyldimethylammonium chloride and an alkylene oxide adduct of a polyhydric alcohol, said alcohol being selected from pentaerythritol, trimethylolpropan, di-trimethylolpropane, polymethylolnonane, neopentylglycol, di-pentaerythritol, glycerine and polyglycerine. It is preferred that the adduct has the mole number of the added alkylene oxide in the range between 4 and 200, more preferably 4 and 100, per one mole of the polyhydric alcohol. The adduct includes an embodiment having the formula (I): in which R is an alkylene having 2 to 4 carbon atoms, a, b, c and d each are zero or an integer of 1 to 50 and the total number of a, b, c and d ranges from 4 to 200. The alkylene oxide adduct preferably contains 20 to 100 mole percent of ethylene oxide based on the total alkylene oxide. The adduct for use in the invention obtained by the addition reaction between a polyhydric alcohol being trivalent or more and an alkylene oxide in the presence of an acid catalyst or an alkali catalyst. The alkylene oxide preferably includes ethylene oxide, propylene oxide, butylene oxide and a mixture thereof. The addition reaction may be conducted so as to obtain a block adduct. It is preferable that a weight ratio of the didecyldimethylammonium chloride to said adduct ranges from 1/0.1 to 1/10, more preferably from 1/0.2 to 1/7. The bactericidal composition of the present invention may be prepared in the form of an aqueous solution of 2 to 50% by weight in concentration and diluted prior to use to give a concentration of 100 to 1000 ppm, although it may vary depending on the subject. In the embodiment of the present invention, various surfactants or other additives may be added to the diluted composition of the present invention to thereby improve the physical properties thereof, for example, to lower the surface tension, to impart the wet maleability or to control foaming. Examples of these additives are nonionic surfactants such as polyoxyethylene (POE) (9) nonylphenyl ether and POE (12) octylphenyl ether; and anionic surfactants such as sodium POE (5) octylphenyl ether sulfate and magnesium POE (6) dodecylphenyl ether sulfate. The bactericidal composition of the invention provides an excellent bactericidal effect even in the presence of organic materials such as feces. This effect is synergistic due to the two components. The following Examples will be presented to further illustrate the present invention. Comparative Example 1 Escherichia coli , which had been previously cultured in a slant medium, was suspended in didecyldimethylammonium chloride diluted to the concentrations as shown in Table 1 for 1, 2.5 and 5 minutes. Then the cells were collected, transplanted to an agar medium and allowed to stand therein for 24 hours, followed by observation of the growth condition thereof. The abovementioned procedure was followed except that 1 % by weight of fowl droppings were added to each didecyldimethylammonium chloride solution. The growth of the E . coli was evaluated according to the following criterion: -: no colony is formed, ±: 1 to 5 colonies are formed, +: 6 to 10 colonies are formed, and ++: 11 or more colonies are formed. Table 1 shows the result. These results suggest that the bactericidal effect of didecyldimethylammonium chloride is lowered under practical conditions, i.e., in the presence of fowl droppings. Example 1 The compositions listed in Table 2 were each prepared, using didecyldimethylammonium chloride, an an alkylene oxide adduct of a polyhydric alcohol and water. The alkylene oxide adduct was an adduct of 8 moles of ethylene oxide to pentaerythritol, called POE(8)pentaerythritol, or an adduct of 8 moles of ethylene oxide and 20 moles of propylene oxide to pentaerythritol, called POE(8)POP(20)pentaerythritol. These compositions were examined about the effect against the growth of E . coli in the same way as shown in Comparative Example 1. Results are shown in Table 3. Comparative Example 2 The procedure of Example 1 was followed except that the preparations were formulated, as shown below, by using POE(8) lauryl ether and POE(7) nonylphenylether for the adduct. Comparative Formulation 1: didecyldimethylammonium chloride 10 % by weight POE (8) lauryl ether 50 water 40 Comparative Example 2 didecyldimethylammonium chloride 10 % by weight POE (7) nonylphenyl ether 50 water 40 Table 4 shows the results. Example 2 The preparations 9 to 13 were each formulated by using 10 wt.% of didecyldimethylammonium chloride, 50 wt.% of an alkylene oxide adduct listed below and 40 wt.% of water and examined about the effect against the growth E . coli in the same way as shown in Comparative Example 1. Results are shown in Table 5. preparation 9 POE(10) trimethylolpropane 10 POE(15) ditrimethylolpropane 11 POE(8)POP(6)glycerine 12 POE(12)dipentaerythritol 13 POE(12)diglycerine

Claims: Claims for the following Contracting States : DE, FR, GB, IT, NL, SE A composition which comprises didecyldimethylammonium chloride and an alkylene oxide adduct of a polyhydric alcohol, said alkohol being selected from pentaerythritol, trimethylolpropane, di-trimethylolpropane, polymethylolnonane, neopentylglycol, di-pentaerythritol, glycerine and polyglycerine. A composition as claimed in claim 1, in which said adduct has the mole number of the added alkylene oxide in the range between 4 and 200 per one mole of the polyhydric alcohol. A composition as claimed in claim 1, in which said adduct has the formula (I): in which R is an alkylene having 2 to 4 carbon atoms, a, b, c and d each are zero or an integer of 1 to 50 and the total number of a, b, c and d ranges from 4 to 200. A composition as claimed in claim 1, in which a weight ratio of said didecyldimethylammonium chloride to the alkylene oxide adduct ranges from 1/0.1 to 1/10. A composition as claimed in claim 1, in which the adduct contains 20 to 100 mole percent of ethylene oxide based on the total alkylene oxide. A composition as claimed in claim 1, which further comprises a surfactant. An aqueous solution which comprises 2 to 50 percent by weight of said composition as defined in claim 1 or 6 and the balance of water. Use of the composition of any of claims 1 to 7 as a bactericide. Claims for the following Contracting State : ES Process for preparing a compositon which comprises mixing didecyldimethylammonium chloride and an alkylene oxide adduct of a polyhydric alcohol, said polyhydric alcohol being selected from pentaerythritol, trimethylolpropane, di-trimethylolpropane, polymethylolnonane, neopentylglycol, di-pentaerythritol, glycerine and polyglycerine. Process for preparing a composition as claimed in claim 1, in which said adduct has the mole number of the added alkylene oxide in the range between 4 and 200 per one mole of the polyhydric alcohol. Process for preparing a composition as claimed in claim 1, in which said adduct has the formula (I): in which R is an alkylene having 2 to 4 carbon atoms, a, b, c and d each are zero or an integer of 1 to 50 and the total number of a, b, c and d ranges from 4 to 200. Process for preparing a composition as claimed in claim 1, in which the amounts of didecyldimethyalammonium chloride and alkylene oxide are chosen such that the weight ratio of said didecyldimehtylammonium chloride to the alkylene oxide adduct ranges from 1/0.1 to 1/10. Process for preparing a composition as claimed in claim 1, in which the adduct contains 20 to 100 mole percent of ethylene oxide based on the total alkylene oxide. Process for preparing a composition as claimed in claim 1, in which a surfactant is also added. Process for preparing an aqueous solution which comprises mitxing the composition prepared in claim 1 or 6 with water in quantities such that the final solution comprises 2 to 50 percent by weight of said composition prepared in claim 1 or 6 and the balance of water. Use of the composition of any of claims 1 to 7 as a bactericide.

Inventors: ARAKI, SEIICHI, HIOKI, YUICHI, IWASAKI, TETSUJI, SUZUKI, MAMORU
Applicants: EISAI CO., LTD., KAO CORPORATION
Application year: 1987
Main classification: A01N33
IPC codes: A01N33, A01N31