LIQUID CRYSTAL COMPOUNDS, MIXTURES AND DEVICES

Abstract: Novel compounds suitable for inclusion in a ferroelectric smectic liquid crystal mixture, having formula (I), where R1 and R2 are independently H, RO, RO1, ROOC, RCOO, RCOOCH(CH3)COO or COOCH(CH3)COOR (R = alkyl) or CN or halogen. Each of the rings may be of (III), which may be substituted, B, C, D are linking groups or single bonds, each of X, Y, Z are different and selected from -O-, COO, OOC, CH2 or CH(W) where W is alkyl, phenyl, cyclohexyl or CN; b, c, d, e, z and also rings (IV and V) have the same lateral substitution pattern. Ferroelectric mixtures containing these compounds, which show room temperature S*c phases are also described.

Description: LIQUID CRYSTAL COMPOUNDS. MIXTURES AND DEVICES. This invention relates to .liquid crystal mixtures and to compounds for use in them. The invention is particularly concerned with ferroelectric smectic liquid crystal mixtures and compounds. The invention also relates to electro-optical devices incorporating these mixtures. Ferroelectric smectic liquid crystal materials utilise the ferroelectric properties of the chiral tilted smectic phase, ie the chiral smectic C, F, G, H, I, F and K phases (hereinafter designated S» etc, the ^ asterisk * denoting chirality). The S« phase is most commonly sought for use in < _\ectro-oρtical devices as it is the most fluid, and it is also desirable that the material shows an S A phase at ' a temperature above the S* phase, to assist in surface alignment. Ferroelectric liquid crystal materials ideally have a low viscosity, a broo^d smectic liquid crystal temperature range, stabi¬ lity ect, and in particular should show a high spontaneous polari- —2 sation co-efficient (Ps, measured in nCcm ). Although some single component materials show these properties, it has become common practice to use a mixture which shows a smectic phase. At least one of the compounds in the mixture is optically active (chiral) so as to induce the smectic phase shown by the mixture to be chiral, esp- * )_ ecially S-,. Such optically active compounds are called "chiral dop¬ ants". According to the present invention a novel compound suitable for inclusion in a ferroelectric smectic liquid crystal mixture has a formula I: where R-. and R ? are independently selected from H, R, RO, ROOC, RCOO, RC00CH(CH, C00 and C00CH(CH-)C00R where R is C 2 alkyl, or from CN or halogen; where each of ( ~ , < s ,/c , ( ~ E is indep- endently selected f • »_-_: „ >—. . H __,_, ,—> <&>"i_ j_9> -&>-< -> ><$ * • and these rings may carry one or more lateral substituents sel¬ ected from halogen, CN or CR,; 0 where B, C and D are independently selected from COO, OOC, CH 2 CH 2 , 0CH 2 , CH 2 0, CH=N, N=CH, N=N or a single bond; where each of b, c, d, e and z is independently 0 or 1, provided (b + c + d + e) is 1, 2 or 3; where each of X, Y, Z are different and are selected from 5 -0-, COO, OOC, CH £ or -C ( H- where H is G η -2- alkyl, phenyl, cyclo- hexyl, halogen or CN, provided that when W is CN then d or e is 1, and further provided that rings \ B / and \ G / w ^ en 0 present have the same lateral substitution pattern. Compounds of formula I are useful constituents of ferroel¬ ectric smectic liquid crystal mixtures. According to a second aspect of the invention there is provided a ferroelectric smectic liquid crystal mixture containing at least two compounds, at least -5 one of which is a compound of formula I. Suitability for use in such a mixture is among the factors determining the structural and other preferences discussed below. The coπrpound of formula I may be optically active, racemic, or non-optically active, but the mixture pre er?jly contains at ° least one optically active compound of formula I. The alkyl group R may be straight chain (-n), branched or when present in other than RC0OCH(CH~)COO or C0UGH(CH )C00R may be chiral. Preferably R 1 and R 2 areindependently alkyl, alkoxy, alkanoyloxy or alkoxycarbonyl. 5 Preferred stibstituents when present of the rings / A \ . B . \ θ ) > \ / J \ E / are F * Compounds wherein one ,CN of these rings is - HV— are paricularly useful. Preferably in formula I is n-alkyl, especially methyl. Preferred structures for the unit -X-Y-(Z)- in formula I are listed in table 1 below: Table 1. " CH- CH- CH, 1 t -> 1.1 -0-CH-C00- 1.2 -OOC-CH-O- l -CH 2 -CH-C00- CH 3 CH- CH,, c 3 1 -C00-CH-CH 2 - 1 -CH-CH 2 - 1.6 -CH-C00-CH 2 - CH, CH 3 CH_, ι 3 1 J 1.7 -CH-CH 2 -C0O- 1.8 -CH 2 -C00-CH- I -CH-CH 2 -00C- CH 3 1.10 -CH 2 -CH- 1.11 -0-CH 2 -C00- Preferred structures for the unit in formula I are listed in table 2 below: Table 2. -©- • - < _]_> • -<&©- ■ <z>(z> ■ 2.8 2,5. 2.10 where the phenyl rings in the r ructures shown in table 2 may casry one lateral halogen substituent. Preferred overall structures for the compound of formula I are listed in table 3 below: Table 3. 3.16 R χ -<Jθ ^θ)-0CH 2 C00R 2 In table 3 R, is C- ,- chain or branched alkyl or alkoxy, 2 is G 1 _ 12 aliyl or alkoxy, or if R 2 is bonded directly to a phenyl or cyclohexyl ring R 2 may also be alkanoyloxy, alkoxy- carbonyl, C00CH(GH-)G H 7 or C00CH(CH 3 )G00G 2 H-. The phenyl rings in table 3 m carry one lateral halogen substituent. Particularly preferred compounds shown in table 3 are those of structures 3-1, 3-2, 3-3, 3 , 3-5, 3-6, 3-7, 3-8, 3-9, and 3.10 in which R 2 is 2-octyloxy (2-methylheptyloxy) , and 3.16. In structure 3-1 B 2 is preferably 2-methyl heptyl. ° No. 199856/ I985 discloses a series of exclusively racemic compounds related to formula I. That disclosure refers exclusively to their use in nem- atic liquid crystal mixtures. It is well known that the physics and chemistry of ferroelectric smectic liquid crystal mixtures is very -5 different to that of neraatic mixtures, particularly in terms of the requirement for miscibility and optical purity. Understanding of ne atic systems thus provides very little guidance in formulating the far more idiosyncratic smectic mixtures. A ferroelectric smectic liquid crystal mixture of the inven¬ 0 tion will normally consist of a number of compounds, and will in¬ clude one or more optically active compounds, preferably at least one of which is a compound of formula I. The other compounds in the mixture will normally include at least one compound which eit¬ her alone or mixed with some or all of the other compounds in the *5 mixture shows a smectic phase, preferably S„, and at least one of these compounds may be a compound of formula I in a racemic form. These other compounds are often called 'smectic hosts' Some examples of smectic hosts include: (a) The compounds, and mixtures thereof, disclosed in PCT/GB36/ 0 OCΛ-O, eg of formula: where R. and R_. are independently selected from alkyl (preferably n-alkyl), alkoxy (preferably n-alkoxy), alkanoyloxy or alkoxy- carbonyl (preferably n-alkoxycarbonyl) and contain 1 - 12 carbon atoms, preferably 3 to 10 carbon atoms. Preferred compounds of this type have structures: where R_ is alkyl. (b) The compounds, and mixtures thereof, of formula:- where R. and R_ are independently alkyl (preferably n-alkyl) or alkoxy (preferably n-alkoxy) and contain up to 12 carbon atoms. (c) Other examples of known smectic host compounds include those of the following general formulae: (racemic) ®" 000 "®-^ where R and R are independently selected from n-alkyl and A __. n-alkoxy and R is n-alkyl, preferably ethyl. (d) r-1-cyano cis - * -( *-alkyl or alkoxy-bipKenyl- -yl)- -1-alkyl or alkoxy cyclohexanes. r.-'l-cyano cis - *Ύ -(trans- -alkyl or alkoxy cyclohexly)- -l-(trans- -alkyl or alkoxy cyclohexyl)-cyclohexanes. The mixture may also contain other optically active compounds which are miscible with smectic materials, for example the lactic acid derivatives disclosed in PCT GB/85/00512, eg or the compounds disclosed in EiPA 0110299., eg: G 3 H 1 6 H 13 or the terpenoid derivatives disclosed in PCT/GB86/0046. If the mixture includes more than one optically active compound, eg a compound of formula I and one of the other optically active compounds mentioned above, then the helical twist senses of the S* phase induced by these compounds may be the same or opposite, eg by the use of both (+) and (-) optically active compounds. It is often desirable to include compounds which induce opposite twist senses of the S* phase in order to increase the helical pitch length. It is desirable that each optically active compound in the mixture induces the same sense of Ps in the mixture. The mixture may also contain other known additives to improve the properties, eg Ps, Sc phase breadth, viscosity etc or to induce the appearance of an S phase of a temperature above the S* to A i_. assist alignment. An example of a class of compounds which may be used to broaden the Sc phase is: where R and R are independently C n-alkyl or n-alkoxy. The mixture may also contain pleochroic dyes. Typically but not exclusively a ferroelectric smectic liquid crystal mixture of the invention will have the following composition: One or more smectic 30 - 99 weight % host compounds Optically active 1 - 50 weight % compound(s) of formula I Other optically active 0 - 20 weight % nor. compoun (s) Additives and pleochroic 0 - 20 weight % dye if present Racemic compound(s) of 0 - 20 weight % formula I 15 The total being 100 weight*. The nature and relative prop¬ ortions of the various components of a liquid crystal material of the invention will depend upon the use for which the material is intended, and some experimentation may be necessary to suit 20 a particular requirement, but the basic principles of mixing and assessment of such materials is well known in the field. Compounds of formula I may be prepared by generally apppli- cable routes. Those which are esters, ie contain a -COO- or -00c- group may be prepared by any of the well known methods of ester 25 synthesis to form the novel products. Some examples of general routes are shown in the experimental examples which follow. A ge¬ neral route for compounds which contain the group -0-CH-COO- or CH 3 ® 3 -OOC-CH-0- is Route A shown in Fig.l, where: 0 5 The sulphonate used in step A(i) is a sulphonate of comm¬ ercially available ethyl lactate. In route A the product of each step should be checked for optical activity if an optically active compound of formula I is required. Methods of preparation of other compounds of formula I will be apparent to the ^ skilled chemist from the experimental examples. The liquid crystal materials of the invention may be used in any of the known types of ferroelectric smectic liquid crystal display device, eg the "Clark-Lagerwall Device'' described in Appl. Phys Lett (1980), 36 899 and in Recent Developments in Condensed Matter * ?hysics (1981), ,309. The physics of this type of device and the method of constructing it are well known, and are described for example in PCT/GB85/00512, and PCT/GB86/0040. In practice such a device usually consists of two substrates, at leastvone of which is optically transparent, electrodes on the inner surfaces of the substrates by which a voltage may be applied and a layer of the liquid crystal materials sandwiched between the substrates. It is desirable that the helical pitch length of the S * phase is comparable to the thickness of the material, which is why long pitch mixtures are useful. The materials of the invention may be used in both the birefringence type display mode and the guest-host type display mode of the Clark-Lagerwall device/ The device may for example be in the form of a clock, calculator or video screen display, and methods of making the device in this form will be well known to those skilled in the art. The invention will now be described by way of example only, with reference to: Fig. 1 which shows preparative route A. Fig. 2 which shows a cros . section through a liquid crystal device. Note: Throughout this description and the following exam- -ples, - H - represents trans- cyclohexyl. Example 1. Preparation of (4-n-Pentyl-4'-biphenylyl)-2-(4"-octoxyphenylGxy)- (S)-propionate (Route A) H0CHC00C-H- CH. l < * - D GH 3 >-© *< so 2 cι — •> GH -/θN-S0 3 CHC00C 2 H 5 (I) GH, (ID 15 0 3 H 17 0-<@)-0CHC00-<g)-<g>-C 5 H 11 CH, 20 Stage I, Ethyl-2(4'-toluene sulphonyloxy) (S)-propionate Ethyl L-(+)-lactate (25 gram. 0.2119 moles) was stirred at room 25 temperature with toluene-4-sulphonyl chloride (50.5 gram, 0.2648) moles and pyridine (75 mis). After 3 hours water (3 mis, 0.1667 moles) was added and the stirring was continued for a further 1 hours. The organic layer was separated and the aqueous layer extracted with dichloromethane (2 x 150 mis). The combined organic material was 30 washed with water (200 mis) and the solvent distilled off using a steam bath. Stage 1 product, 50.9 gram, 88% yield was obtained which was purified by recrystallisation from propan-2-ol (150 mis) to produce 30.9 gram of a white solid melting at 32-33°C, and having a purity by HPLC of 99.9%. 35 Stage II , Ethyl-2-(4' -n-octoxyphenyloxy) (S ) -propionate ( step A( i ) ) Stage I product (10 gram, 0.03676 moles) was stirred and boiled under reflux with 4-n-octoxyphenol (8.16 gram, 0.03676 moles) and anhydrous potassium carbonate (10 gram) in butanone (100 mis) for 24 hours. The product isolated by addition of the cooled reaction mixture to water (20U mis) followed by separation and extraction of the aqueous with dichloromethane (2 x 150 mis). The combined organic material was washed with water (200 mis) then dried over sodium sulphate and evaporated to dryness to give a crude yield of 18.25g. This was purified by column chromatography on basic alumina (72g) and eluted with petroleum spirit (bp 60-80°). This gave a yield of 10.Og, 85%. Stage III, 2-(4'-0ctoxyphenyloxy) (S)-propionic acid (step A(ii)) Stage II (11.9 gram, 0.03696 moles) was boiled under reflux with potassium hydroxide (6g) industrial methylated spirit (75 is) and water (15 mis) for 3% hours. The product was isolated by adding the cooled reaction mixture to 10% hydrochloric acid (250 is). The product was filtered off, washed with water and dried in vacuum at 40°C. A yield of 8.9g, 82% was obtained. Stage IV, (4-n-Pentyl 4'-biphenylyl) 2-(4"-octoxyphenyloxy)-(S)- proprionate (steps A(iii) and (iv)) he above was prepared by first forming the acid chloride of stage III. Stage III (8.5g, 0.02891 moles) was boiled under reflux with thionyl chloride (27 mis) for 2 hours, the excess thionyl chloride was then evaporated off on a steam bath and finally under high vacuum (0.1 mbar); This acid chloride was then added to 4'-hydroxy-4-ri-pentyl biphenyl (6.9g, 0.02891 moles) dissolved in dichloromethane (125 mis) and triethylamine (12.5 is). This mixture was boiled under reflux for 1 hour and 10 minutes, allowed to cool and the product isolated by addition to water, (150 mis) followed by separation and subsequent washing with hydrochloric acid (150 mis of 10%) and with water (150 mis) The solvent was evaporated off to give a yield of crude product, 13.6g, 91.3% of theory. This was purified by column chromatography on basic alumina (50g) and eluted with petroleum spirit (bp 60-80°) and dichloromethane mixture in the ratio 2:1. A yield of 9.0 grams, 60.4% of theory was obtained which was further purified by recrystallisation from industrial methylated spirit (70 mis) plus pyridine (0.75 mis). (4-n-Pentyl-4'-biphenyly1) 2-(4"-octoxyphenyloxy)- (S)-propionate (8.0 gram) was obtained in a yieid of 54% of theory, and having a melting point, K-I of 86°C. The spontaneous polarisation Ps of the product of Example 1 was measured at 10 concentration in a mixture of: 33.3% C 8 H 1°-CK co C 5 H 1 1 5 which had the trans ition temperature S -S^ 90°, S -Ch 94° and A Ch-I 1 33-136 ° The variation of spontaneous polarisation of this mixture with Q temperature was as follows:- 50 0.41 55 0.59 60 0.75 5 70 0.87 80 0.80 85 0.56 88 0.28 89 0.16 By an analogous method the compound: was prepared, having a melting point crystal - isotropic of 6 * °C. Example 2 2.98 g (0.01 mole) of 4-(5-heptylpyrimidinyl-(2) )-benzo ic acid, 2.5 g (0.01 mole) of levorotatory 3-(4-heptyloxy phenyl-(l))-propanol-(2), α^° = -3.15 (c = 1 in CH 2 Cl 2 ), 10 prepared from commercially available R-propylenoxide and heptyloxyphenylmagnesiumbromide, 2,3 g of dicyclohexyl- carbodiimide, 0.2 g of 4-N,N-dimethylaminopyridine and 25 ml of dichloromethane are stirred together 48 hours at room temperature. Thereafter, the reaction mixture is cooled Ij down by external ice and the precipitate of dicyclohexyl- urea is filtered off and washed with dichloromethane. The combined filtrates of the dichloromethane solutions are chromatographied after evaporation on silica gel with toluene/2 % ethylacetate. The main fraction.yields after 20 crystallisation from ethanol l-(p-heptyloxyphenyl)-2-propyl- 4-(5-heptylpyrimidinyl-(2))-benzoate, which is according to HPLC 99.1 % pure. (αj° = _ 80 .6) H.Pt 76.2 oG 2 $ melting enthalpy 8,l6 kcal/mole In a similar way the following acids yield the corres¬ ponding esters by esterification with levorotatory l-(4-heptyloxyphenyl)-2-propanol: 30 R- O \ - H YcOOH Example 3 Esterification of optically active l-(4'-heptyloxybiphenyl- 4-yl)-propane-2-oi (prepared from R-propylenoxide and 4'- heptyloxybiphenyl-4-yl-magnesiumbomide) with butyric acid in a similar way as described in example 2. yields optically active l-(4'-heptyloxybiphenyl-4-yl)-2-propyl butyrate. In a similai way the following 2-propanol derivatives yield the corresponding esters by sterification with aliphatic carboxylic acids: R- H H V O cH j CHCH j OH Example • * 3.16 g (0.01 mole) of 4-(5-heptyloxypyrimidinyl-(2 ) )- benzoic acid chloride are added to 15 ml of pyridine con¬ taining 2.5 g (0.01 mole) of dextrorotatory 3-(4-heptyl- oxyphenyl-(l))-propanol-(2), a^ = +3.14 (c = 1 in CH 2 C1 2 ), prepared from commercially available S-propylenoxide and heptyloxyphenylmagnesium bromide, at 0 °C under stirring. After completed addition the reaction mixture - " * allowed to warm up to room temperature and stirred overnight. The mixture is then poured into 150 ml of water and extracted with toluene. The toluene layer is subsequently washed with diluted HCl, diluted NaOH and water, then dried over Na 2 S0 4 and evaporated. The residue is chromatographied over silica gel by eluting with toluene yielding the ester, which after crystallisation from acetonitrile and cyclohexane give pure material of l-(p-heptyloxy- phenyl)-2-propyl-4-(5-heptylpyrimidinyl-(2) )-benzoate. Analogously the corresponding esters were prepared by esterification of the following acid chlorides with dextrorotatory 3-(4-heptyloxyphenyl-(l) )-propanol-(2) R -( o VcH g CH 0 VcOCl Example 5 3.4 g (0.01 mole) of dextrorotatory 3-[4-(5-heptylpyrimi- dinyl-(2) )-phenyl-(l)] -butyric acid, prepared by hydrogena- tion of the corresponding 2-butenic acid on 5 % Pd/charcoal in tetrahydrofuran and resolution by (+)ephedrin (2-methyl- ammo-l-phenylpropanol-(l) ), c_ 2j0 = + 3.30 (c = 1 in CH 2 C1 2 ), are esterified by the method given in example 1 with 1.42 g of trans 4-propylcyclohexanol. After purification by chroma- tography and crystallisation optically active trans-4-pro- pylcyclohexyl-3-[4-(5-heptylpyrimidinyl-(2) ) -phenyl- (1 )] - butyrate is obtained. Analogously by esterification with the alcohols given below the corresponding esters were prepared: - ■CH, HO-< \ 0 / >-C 5 c H",11 -o HO-< 0 >-OC 5 H C 5 H 11 5"11 HO- ( CH 2 ) 5 -CH 3 HO- / 0 Vc 8 H 17 HO-CH 2 -CH-CH 2 CH 3 -ZηK_ CH 3 Example 6 1.7 g of levorotatory 3-[4-(5-heptylpyrimidinyl-(2) )- phenyl-(1)]-butyric acid (c_ D 20 = -3.30), obtained as in the previous example by resolution, are converted in the usual manner with SOCl 2 to the corresponding acid chloride, which is dissolved in 10 ml of diethylether and dropped to a solution containing 3 ml of pyridin and 1.64 g of 4-pen- tylphenol in 15 ml of diethylether at 0 °C. After one hour additional stirring at 0 °C, the mixture is stirred at room temperature overnight. After extraction of the neutral components and chromotographic separation optically active p-pentylphenyl 3-[4-(5-heptylpyrimidinyl-(2) )-phenyl-(1)]- butyrate is obtained. Analogously corresponding esters were prepared by esteri¬ fication of the following alcohols: H °-G- .) "C 7 H 11 H0 0 }- C 4 H 9 Example 7 3.97 g of the Cs-salt derived from the all-trans 4-(4'- propylcyclohexyl)-cyclohexane-acetic acid, prepared from the equivalent amount of Cesium carbonate (Cs 2 CO~) and the acid by combining the components in dimethylformamide and evapora tion of the dimethylformamide, are reacted with 2.55 g of dextrorotatory l-bromo-l-(4-pentylphenyl)-ethan at 60 °C under stirring overnight in 30 ml dimethylformamide. The reaction mixture is poured into water, extracted with n-hexa dried, evaporated and filtrated on silica-gel. After recryst sation from acetonitrile l-(p-pentylphenyl)-l-ethyl all-tran 4-(4'-propylcyclohexyl)-cyclohexylacetate is obtained. The following acids yield the corresponding esters by the same method: ( levo- and dextrorotatory) fi ll C 5 o" >-- < CO 2 H Example 8 153.47 g (0.01 mole) of the optical active α-chloropropionic- acidester of p-(5-hexylpyrimidin-2-yl)-phenol described in the German Patent Application DE-OS 3515373 are reacted with 2.15 g of sodium-p-heptylphenolate in 20 ml of N-methyl pyrrolidone at 80 °C during two hours. The resulting reactio 20 mixture is poured into water, extracted with toluene, the toluene layer is dried and evaporated. The residue is chromatographied on silica gel with toluene/1 % acteone. The main fraction yields after recrystallisation optically active p-(5-hexylpyrimidin-2-yl)-phenyl 2-(p-heptylphenoxy)- 25 propionate. By reaction of the nucleophiles given below the correspond¬ ing derivatives were obtained in an analogous way. 0 & 00--((CCHH 2 „ )) 6c --CCHH 3 .-, 35 Θ CH 2 -C N e> O-CH. < > ■ C 3 H 7 Example 9 3.4 g (0.01 mol) of levorotatory 3-[4-(5-heptylpyrimidinyl- (2) )-phenyl-(l)]-2-methylpropionic acid (c 20 D = 2.3 in CH 2 C1 2 ), obtained by resolution with (+)ephedrin and pre¬ paration of the racemic acid by hydrogenation of the corres¬ ponding o.-methyl cinnamic acid with 5 % Pd on charcoal in tetrahydrofuran, are esterified with 2.20 g of nonylphenol. according to example 2. Optically active p-nonylphenyl 3- [4-(5-heptylpyrimidinyl-(2) )-phenyl-(1)]-2-methylpropionate is obtained. Analogously the following α-methylpropionic acid derivatives were converted to the corresponding 4-nonylphenolic esters . Example 10 CH, H 7 C 3 -<5>-( >-CH 2 CH-<0 C^ To a mixture of 2.7 g (0.01 mole) of levorotatory 4-(2- bromo-l-methylethyl-(l) )-l-pentylbenzene and 66 mg of i 2 CuCl 4 (3 mol %) in 30 ml of tetrahydrofuran 10 ml of a tetrahydrofuran solution, containing the Grignard reagent prepared form 2.69 g (0.01 mole) of 1-bromo- 4-(4-propylcyclohexyl)-benzene and 0.24 g of magnesium, are added dropwise under nitrogen and stirring at room temperature. After stirring for 16 hours at room tempera- ture the reaction mixture is hydrolysed with 6N HCl and evaporated. The residue is treated with dilute HCl and diethylether. The etherical layer is washed until neutral, dried and evaporated. The residue yields after chromato- graphy with n-hexane and crystallisation the optically activecross coupled compound l-[p-(trans-4-propylcyclo- hexyl)-phenyl]-2-(p-pentylphenyl)-propane. Analogously the Grignard compounds of the following . bromides were cross coupled. H 11 C ! '<__>-<__}- Br Example ^ 2.26 g (0.01 mole) levorotatory trans 2-( -pentylcyclo¬ hexyl-(l)-propionic acid, prepared by α-methylation of the corresponding acetic acid and separation of the diastereomers of the corresponding phenylglycinolamides and hydrolysis, are esterified as described in example 5 via the corresponding acid chlorid. Optically active trans-4-propyl-cyclohexylmethyl 2-(trans-4-pentylcyclo- hexyl-(l)-propionate is obtained. By using the alcohols listed below the corresponding esters were obtained. HO -CH 2 : --<<-0O >>--oOcC 77 ιH 15 5 ^0-CH 2 -(^C 5 -H 11 -CH 2 -<^-<^-C 3 H, 5 HO-CH„-< O ^-C^g Example 12 7.9 ml azobisethoxycarbonyl are added dropwise to a solution of 10.9 g p-(trans-4-propyl-cyclohexyl)-phenol, 5.8 ml of (S)-ethyl lactate, and 3.1 g triphenylphosphine in 150 ml of tetrahydrofuran at room temperature. The resulting mixture is stirred over night and evaporated,. A suspension of the residue in a mixture of 90 ml of CH-OH (90 %) and 50 ml of CH 2 C1 2 is mixed with 5 ml of H 2 0 2 . After 15 minutes aqueous Na 2 S 2 0 5 and subsequently 100 ml of water are added. The organic layer is washed with NaHC0 3 , water an dried over Na 2 S0 4 - After evaporation the residue is chormato graphied on silica gel. Opticall active ethyl 2-[p-(trans-4- propylcyclohexyl(-phenoxy]-propanoate is obtained, bp. 180 ° (0.06 Torr) . Iri a similar way the following phenols yield the correspondi lactate elders by etherification with ethyl lactate, methyl lactate, propyl lactate, hexyl lactate, heptyl lactate, 2- methylbutyl lactate or similar lactates: R-<θHθ)-0H - -ώ-Θ- Example 13 To a mixture of 4-(4'-hydroxybiphenyl-4--yl)-l-cyan-l-octylcyclohexane (19.4g), ethyl lactate (6.5g) and triphenylphosphine (13.lg) in tetrahydrofuran (300 ml) was added diethylazodicarboxylate (9.6g) dissolved in tetrahydrofuran. The mixture was stirred for 1 hour at 50°C and then left to stand overnight. The solvent was removed and the residue was dissolved in hot toluene (100 ml) , which was then colled to 0°C and filtered. The product was isolated from the filtrate by chromatography. By this route optically active 2-(4'-(4-cyan-4-octylcyclohexyl)- biphenyl-4-yloxy) propionic acid esters were obtained. By analogous methods using alkyl lactates and phenols of formulae: CN CN HO -@>" 0 CO-(~Hy lkyl , CN CN analogo s compounds were prepared. Example 14 To a mixture of p-hydroxybenzoic acid-(4-cyano-4-heptylcyclohexyl)-ester (20.6g) , prepared by reacting 4-cyano-4-cyclohexanol with p-benzyloxybenzoic acid and removing the benzyl group by catalytic hydrogenation, optically active hexyl lactate (11.5g) and triphenyl¬ phosphine (15.7g) in tetrahydrofuran (150 ml) was added a solution of diethylazodicarboxylate in tetrahydrofuran. The mixture was stirred for 1 hour at 50°C and the solvent was removed after 12 hours standing. The residue was dissolved in hot toluene (100 ml) , cooled, filtered and the product was isolated by chromatography and crystallisation. By this route optically active p-(4-cyano-4-heptylcyclotexyloxycarbonyl)- phenoxypropionic acid hexyl esters were obtained. By analogous routes using alkyl lactates and the phenols below, analogous compounds were prepared. CN H0-S-(p)-0C0-(]H Llkl CN CN Example 1 ( S-1-methyl heptyl ^-n-decylbiphenyl-4'-oxyacetate ) Stage I ( ethyl — -decylbiphenyl - '-oxyacetate ) A 500 ml round bottomed flask was charged with 4-n-decyl- 4'-hydroxyblphenyl (lOg), ethylbromc acetate (6.5g), anhydrous potassium carbonate (6.6g), and butanone (160 mis). The lo- resulting mixture was stirred and boiled under reflux for 20 hours. The reaction mixture was filtered hot through a Whatman 541 filter paper, and the butanone removed on a rotary evaporator to yield the crude product as a light yellow solid (12g). The material was purified by recrystallisation from 24 mis of industrial methylated spirit to yield a white crystalline product (8.9g). 1-5 Stage II ( -n-decylbiphenyl- -'-oxyacetic acid ) A mixture of ethyl 4-n-decylbiphenyl-4'-oxyacetate (9.8g), potassium hydroxide (3.5g), water (11 mis), and industrial methylated spirit(400 mis) was stirred and heated under reflux overnight. T e reaction mixture was cooled, added to 2 litres of cold water and acidified to pH 1 by the addition 20 of concentrated hydrochloric acid. The resulting precipitated solid was filtered off, dried, and used in the following stage of the synthesis without further purification. The yield was 8.3 grams. Stage III ( S-1-methylheptyl -n-decylbiphenyl- - ^5 -oxyacetate A mixture of 4-n-decylbiphenyl-4'-oxyacetic acid (4g), S-2-octanol (1.56g), dicyclohexyl carbodiimide (2.47g), 4-dimethylamino pyridine (0.2g) and dichloromethane (50 mis) was stirred overnight at room temperature. The reaction mixture was filtered, the solid residue washed with dichloromethane (25 mis) and the combined liquid extracts evaporated to 30 dryness on a rotary evaporator. The product was an off white solid (5.2g). The product was purified by chromatography on 52g neutral alumina, eluted with petroleum ether, followed by recrystallisation from 10 mis of industrial methylated spirit. The yield of pure white product, purity 99.9% by hplc was 1.15g. Melting point was recorded as 42 - 42.5°C. 35 By analogous methods the following compounds were prepared: obtained as white solid, purity by hplc 99-5 % rapt. 53-5 - 5 * +°C solid xtal - S c - 87°G S Q - N = 110°C N - I = 111°C Ferroelectric smectic liquid crystal compositions were prepared containing compounds (A) and (B) above. Each composition contained 10 v fo of the compound in a host consisting of: totalling 100 wt% with the compound (A) or (B). The mixtures are designated mixture (A) and (B) as appropriate belowt _ 2 LC Transitions ( C) Ps (nC cm~ ) Example 16 From p-hexylbenzoic acid and l-(4'-octoxybiphenyl-4-yl) propan-2-ol, prepared from S-(-)propylene oxide, was made the (+)-p-hexylbenzoic acid (l-)(4'-octoxybiphenyl-4-yl)-2-propyl ester: CH C 8 H l° 2>-<δ>-? ΪCH 2 00G ^)- G 6 H l3 This had a melting point of 67°C and /=_/_ of + 66.0° at a concentration of 5wt°_ in dichloromethane. Example 17 Properties of some other compounds of formula I which were prepared using the methods described herein are given belo . C 3 H 7 -(H)I- .OCHCH3C00CH3 m . p. 12° C 3 H 7 - H . -OCHCH3COOC 4 H g ■ m. p. 0 o C 7 H 15"<i 0- 0 C HCH 3CαθC 4 H 9 m. p . 18 o C g H ι (oJ{- -0CHCH3C00C 2 H 5 m. p . 33 o CgH 19 -(o[J- o -0CHCH 3 C00C :i 9 m. p. 21° CI ) Exaπrole ~& An example of a ferroelectric smectic liquid crystal composition which includes a compound of Formula I . Component _ __ 2-p-nonyloxyphenyl-5-heρtylpyrimidine 3 2-p-hexyloxyphenyl-5-nonylpyrimidine 7 2-p-nonyloxyphenyl-5-nonylpyrimidine 23 -1-butylcyclohexane r-1-cyano-cis- -(^f-*-heptylbiphenyl- -yl) I 1< -1-hexylcyclohexane ' r-l-cyano-cis- -(trans- -pentylcyclohexyl) l 6 -l-(trans- —pentyl-cyclohexyl)-cyclohexane 2-p-heptyloxyphenyl-5-heptylpyrimidine 2-p-octyloxyphenyl-5-heptylpyrimidine 3 2-p-hexyloxyphenyl-5-heptylpyrimidine The above mixture showed: S G \ S A 56 Ch 95 I -2 The spontaneous polarisation Ps was +4.3 nCcm " at 25 G Example 19 An example of a ferroelectric smectic liquid crystal composition: Component wt% 2-p-nonyloxyphenyl-5-heptylpyrimidine 3 2-p-hexyloxyphenyl-5-nonylpyrimidine 7 ?-p-nonyloxyphenyl-5-nonylpyrimidine 23 r-l-cyano-cis-4-(4'-octyloxybiphenyl-4-yl) 28 -1-butylcyclohexane r—2-cyano-cis-4-(4'-he ylbiphenyl-4-yl) 14 -1-hexyleye1ohexane r-l-cyano-cis-4-(trans-4-pentylcyclohexyl -1-(trans-4-penty1-cyclohex 1)-eyelohexane 2-p-heptyloxyphenyl-5-heptylpyrimidine 3 2-p-octyloxyphenyl-5-heptylpyrimidine 3 The above mixture showed: S* 63 S Λ 64 Ch 89 I C A _2 The spontaneous polarisation Ps was +10,4 nCcm at 20°C. JP/22 example 20 The racemic compound: G H 9 (t3-C 10 H 21 -Q > -<O -0GHG00C 2 H 5 mp. 25°C was prepared using a modification of route A in which the ethyl ester of the known D -hydroxycarboxylic acid C^H CH(0H)C0OH was used instead of ethyl lactate, from which the sulphonate was prepared. By using other known ON, - hydroxycarboxylic 10 acids, eg C 2 H £ .GH(OH)COOH G H ? CH(OH)COOH G i i:L GH(0H)C00H and preparing other alkyl, cycloalkyl or phenyl etc esters , - of such acids, analogous compounds could be prepared. Alternately the , -hydroxycarboxylic acid could be synthesised from known aldehydes via the cyanohydrins, and subsequent hydrolysis ie: OH OH 20 R-CHO • RCH-CN • RCH-C00H (±) HCN (anhy- cone. HCl, drous), KCN 12 hr 50°G (trace); H 2 - The racemic acid may be optically resolved using brucine, via known methods. R represents the appropriate alkyl group. Alternately, the above compound was prepared by the reaction of commercially available (Aldrich) (-)-ethyl-2_-bro- mo hexanoate with the appropriate phenol: The product was isolated and purified using standard proced¬ ures. An example of the use of a compound of Formula I in a liquid crystal material and device embodying the present inven¬ tion will now be described with reference to Figure 2. In Figure 2 a liquid crystal cell comprises a layer 1 of liquid crystal material exhibiting a chiral smectic phase sand¬ wiched between a glass slide 2 having a transparent conducting layer 3 on its surface, eg of tin oxide or indium oxide, and a glass slide 4 having a transparent conducting layer 5 on its surface. The slides 2,4 bearing he layers 3>5 are respec- tively coated by films 6,7 of a polyimide polymer. Prior to construction of the cell the films 6 and7 are rubbed with a soft tissue in a given direction tha rubbing directions being arranged parallel upon construction of the cell. A spacer 8 eg of polymethylmethacrylate, separates the slides 2,4 to the required distance, eg 5 microns. The liquid crystal material 1 is introduced between the slides 2,4 to the required distance, eg 5 microns. The liquid crystal material 1 is introduced between the slides 2,4 by filling the space between the slides 2, and spacer 8 and sealing the spacer 8 in a vacuum in a known way. Preferably, the liquid crystal material in the smectic A or isotropic liquid phase (obtained by heating the material) when it is introduced beteen the slides 2,4 to facilitate alignment of the liquid crystal molecules with the rubbing directions on the slides 2,4- A polarizer 9 is arranged with its polarization axis parallel to the rubbing direction on the films 6,7 and an analyzer (crossed polarizer)10 is arranged with its polar¬ ization axis perpendicular to that rubbing direction. When a square wave voltage (from a conventional source not shown) varying between about +10 volts and -10 volts is applied across the cell by making contact with the layers 3 and 5 the cell is rapidly switched upon the change in sign of the voltage between a dark state and a light state as explained above. In an alternative device (not shown) based on the cell construction shown in Figure tne layers and 5 ™ay be selectively shaped in a known way, eg by photoetching or deposition through a mask, eg to provide one or more display symbols, eg letters, numerals, words or graphics and the like as conventionally seen on displays. The electrode portions formed thereby may be addressed In a variety of ways which include multiplexed operation. The ferroelectric smectic liquid crystal compositions described above, which show room temperature S G phases may be used as the liquid crystal material 1. The compositions of Examples 15, 18 and 19 were part¬ icularly suitable for use in this device.

Claims: GIAIMS 1. A compound suitable for inclusion in a ferroelectric smectic liqui crystal mixture, having a formula I: where R, and 2 are independently selected from H, R, RO, ROOG, RGOO, RG0OGH(CH 3 )GO0 and G00GH(GH 3 )G00R where R is G^^ alkyl, or from CN or haloge j where each of 3 s is indep¬ endently selected fggm: /-v and these rings may carry one or more lateral substituents sel¬ ected from halogen, CN or CH,; where B, G and D are independently selected from COO, OOC, CH 2 CH 2 , 0CH 2 , CH 2 0, CH=N, N=GH, N=N or a single bond; where each of b, c, d, e and z is independently 0 or 1, provided (b + c + d + e) is 1, 2 or 3( where each of X, Y, Z are different and are selected from -0-, GOO, OOC, GH 2 or -GH-. where is C- j - alkyl, phenyl, cyclo- W hexyl, halogen or CN, provided that when H is CN then d or e is 1, and further provided that rings ( ~ 3 ' and when present have the same lateral ?Λstitution pattern. 2. A compound according to claim 1 characterised in that R-. and R 2 are independently alkyl, alkoxy, alkanoyloxy or alkoxy carbonyl. 3. A compound according to claim 1 or claim 2 characterised in that W is n-alkyl. 4. A compound according to claim 3 characterised in that is methyl. 5. A compound according to claim 1, 2 or 3 characterised in that X-Y-(Z)- is selected from: CH, OL, 1 J CH 3 -0-CH-G00- -OOG-GH-O- -CH 2 -CH-GOO- CH, -C00-CH-CH 2 - -CΉ-CH 2 - -CH-C00-CH 2 - CH, CH 3 CH, 1 1 J -CH-GH 2 -G00- -GH 2 -C00-CH- -CH-CH 2 -00G- CH, 1 J -CH 2 -CH- -O-CH 2 -GOO- A compound according to claim 1, 2, 3, 4 or 5 characterised in that is selected from: -©- • -<__> • -<&©- ■ <ZΪXZ> ■ NC -φ®- ■ * δ>-<ϊ • <_Xd>-<& ■ -<°> * -®- - -<cfc * @- -<2V °>- where the phenyl rings may carry one lateral halogen substituent. 7. A compound according to claim 5 oτ 6 having a formula selected from: where R-, is C, , 0 straight chain or branched alkyl or alkoxy, R 2 is G, , 2 alkyl or alkoxy, or if R 2 is bonded directly to a phenyl or cyclohexyl ring R ? may be alkanoyloxy, alkoxycarbonyl, C00- -(2l(CH.,) ,H 7 , or C00CH(CH„)C00C 2 H ( , and the phenyl rings my carry one lateral halogen substituent. 8. A compound according to claim 5 or 6, having a formula where R 2 is 2-methylheptyloxy. 9- A conrpound according to claim 1 characterised in that R JS straight chain C, , 2 alkyl. 10. A compound according to claim 1 characterised in that one CN of X\ i~\ O> / " DS and ( ~ s /H~ - 11. A ferroelectric smectic liquid crystal material, being a mixture of compounds, characterised in that at least one is a compound of formula I, and at least one is a compound which shows a smectic phase, the mixture having a composition: compound(s) of formula I 1 - 50 wt % coπrpound(s) showing a smectic phase 50 - 99 wt % 12. A material according to claim 11, characterised in that at least one of the compounds which shows a smectic phase has a formula: where R. and R_ are independently alkyl, alkoxy, alkanoyloxy or alkoxycarbonyl. 13. A material according to claim 12 characterisd in that R. and R_ are independently n-alkyl, n-alkoxy or n-alkoxycarbonyl. 14. A material according to claim 12 characterised in that at least one of the compounds which shows a smectic phase has a formula selected from: _> or R A -® §>- GOO -®-ooR c where R-, is alkyl. 15. A material according to claim 11 characterised in that at least one of the compounds which shows a smectic phase has a formula: where R. and R- are independently alkyl or alkoxy. 16. A material according to claim 15 characterised iϋ that R. and R_g are independently n-alkyl or n-alkoxy. 17. A liquid crystal electro-optic display device characterised in that it uses a liquid crystal material as claimed ii* claim 11.

Inventors: ESCHER KLAUS, JENNER JOHN ANTHONY, KURMEIER HANS ADOLF, PAULUTH DETLEF, POETSCH EIKE, SAGE IAN CHARLES, ESCHER, KLAUS, JENNER, JOHN, ANTHONY, KURMEIER, HANS, ADOLF, PAULUTH, DETLEF, POETSCH, EIKE, SAGE, IAN, CHARLES
Applicants: SECR DEFENCE BRIT, THE SECRETARY OF STATE FOR DEFENCE IN HER MAJESTY'
Application year: 1987
Main classification: C07C69
IPC codes: C07C1, C07C43, C07C69, C07C255, C07D213, C07D237, C07D239, C07D241, C07D253, C07D319, C09K19, G02F1