MOISTURE-RETAINING PREPARATION FOR DERMAL USE

Abstract: A preparation for dermal use which contains sake es­ sence as a moisture-retaining agent has adequate moisture­ retaining property.

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to a preparation to be applied to the skin which contains sake essence as a moisture-retaining agent. 2. Description of the Prior Art Moisture-retaining agents are essential components in preparations to be applied to the skin, such as ointments, creams, gels and lotions, in order to maintain the moisture content of the skin at a constant level. Glycerin, sorbitol, aloe extract and placenta extract are so far known examples of the moistureretaining agents. Glycerin and sorbitol are inexpensive and good synthetic moisture-retaining agents. On the contrary, the aloe extract, an extract from a natural product, has a drawback that it causes discoloration of preparations and the placenta extract, another nature-origin moisture-retaining agent is hardly accessible and very expensive. Thus, any satisfactory moisture-retaining agents of nature origin have not yet been known. Under these circumstances, inexpensive and safe moisture-retaining agents of nature origin which are free of such drawbacks as mentioned above have been searched for in recent years. Accordingly, the present inventors made intensive investigations in search of a moisture-retaining agent which is of nature origin and excellent in quality and, as a result, found that the residue after distillation of sake, namely the so-called sake essence, has potent moisture-retaining property. The present invention has been completed on the basis of this finding. SUMMARY OF THE INVENTION Thus, the invention consists in incorporating sake essence, as a moisture-retaining agent, preparations to be applied to the skin, such as creams, gels, ointments and lotions. DETAILED DESCRIPTION OF THE INVENTION In accordance with the invention, sake essence is used for the same purposes as in the case moistureretaining agents generally incorporated into preparations for dermal use. Therefore, there are no particular limitations or restrictions as to the other components of such preparations than the moisturerataining agent. Furthermore, sake essence can be used in combination with other moisture-retaining agents. The term "preparation for dermal use" as used herein includes, within the meaning thereof, pharmaceutical or cosmetic preparations to be applied to the skin, whether for medical purposes or not, such as, for example, ointments, gels, packs, lotions and skin creams. The term "sake essence" as used herein includes, within the meaning thereof, a syrupy residual concentrate obtained after removal from sake of volatile components, such as alcohols, by distillation and a lyophilizate obtained from such concentrate. The term "sake" as used herein means a wine made from rice or starch as the main raw material by alcoholic fermentation. In the experiment, sake essence and other moisture-retaining agents were compared with respect to their moisture-absorbing and moisture-retaining properties. Thus, 1 g of each sample was placed in a 5-ml beaker and allowed to stand in a constant-temperature, constant-humidity chamber(300C,90% or 38% RH ), with sample weighing at timed intervals. The sake essence used in this experiment was a powder obtained by lyophilization of a sake essence concentrate, which in turn was obtained from second-grade sake (produced by Tamon Shuzo Kabushiki Kaisha) by concentration under reduced pressure, and this powder was dissolved in water to give a 70%(W/V) solution. Analytical data indicated that the carbohydrate content of said powder essence was about 90% and the protein content about 7.4%. The results obtained in said experiment are graphically shown in Fig. 1 (moisture-retaining effect curve). As is evident from Fig. 1, the increse in water content, namely the hygroscopicity, was less with the 70%(W/V) sake essence than with 708(W/V) glycerin or sorbitol and the loss in water, namely the moistureretaining effect, was substantially the same between the 70% sake essence and 70% glycerin or sorbitol. The above results indicate that sake essence is sufficiently effective as a moisture-retaining agent for use in preparations for dermal use. Moreover, sake essence to be used as a moistureretaining agent in accordance with the invention is advantageous over glycerin or sorbitol in that it contains a number of skin-nourishing ingredients such as carbohydrates, proteins, amino acids and vitamins. In a blindfold test using a panel of 10 women, three kinds of cosmetic creams, namely the cream of Example 5 with sake essence incorporated therein and two corresponding creams with 5% of sorbitol and 5% of glycerin respectively incorporated therein in lieu of 5% of sake essence were comparatively evaluated with respect to impressions after use thereof. The creams were evaluated in the five aspects given below and scored in the manner mentioned below. Aspects: (1) Moisturizing effect, (2) Nonstickiness, (3) Extendability, (4) Affinity for the skin, and (5) Foundation (for makeup) effect. 4 Scores x to s 3 for the first cream in the order of preference, 2 for the second, and 1 for the third. The result thus obtained are shown in Table 1 in terms of the total score given by the 10 panelists. Table 1 Aspect Example 5 5% sorbitol 5% glycerin (5% sake essence) (1) 29 17 14 (2) 27 16 17 (3) 30 15 15 (4) 30 15 15 (5) 28 16 16 It was thus found that the formulation of Example 5, which contains 5% of sake essence, is superior in every aspect to the formulation using, as the moistureretaining agent, 5% of sorbitol and 5% of glycerin, respectively. In the above test, any panelists did not complain dermal irritation, pain, nor itchness. Further, there could not found any congestion nor swelling at the application sites of the panelists. Thus, it is evident that all of these moisture-retaining agents including sake essence have no harmful effect to human skin. The concentration of sake essence in preparations may vary depending on the final form of preparations, the mode of use, and so forth. Generally, however, it is recommended that sake essence be used in a concentration of about 0.1 to 40 (W/V) percent, preferably about to 1.0 to 30 (W/V) percent, as calculated on the sake essence solids basis. When intented for medical use, the preparations for dermal use which contain sake essence in accordance with the invention may naturally contain one or more pharmacologically active ingredients. When intended for cosmetic use, they may contain various materials in common use in cosmetic preparations. The preparations may further contain surfactants (e.g. polyoxyethylenesorbitan monooleate, polyoxyethyleneglycerin monostearate, glycerin monostearate, sorbitan monooleate, propylene glycol monostearate, polyethylene glycol monostearate, polyoxyethylene lauryl ether, polyoxyethylenepolyoxypropylene cetyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylenehydrogenated castor oil, sodium lauryl sulfate, sodium polyoxyethylene oleyl ether phosphate), preservatives(e.g. benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, chlorobutanol, p-hydroxybenzoic acid esters, cetyltrimethylammonium bromide, sorbic acid), pH adjusting agents (e.g. citric acid, lactic acid, carbonic acid, phosphoric acid, acetic acid, salts of these, sodium hydroxide, potassium hydroxide, hydrochloric acid), and so on, without any impairment thereof. Furthermore, they may contain appropriate fragrances, colorants, and so forth as desired. The following example are futher illustrative of the present invention. The sake essence (powder) used therein was prepared by concentrating 1 liter of second-grade sake (produced by Tampon Shuzo) under reduced pressure and lyophilizing the essence concentrate thus obtained. Yield 60 g (6%). The "sake essence, 70(W/V) percent" as so referred to in the example, was prepared by adding water to the powderform essence to an essence concentration of 70(W/V) percent. Example 1 Ointment Zinc white 25 g Talc 10 g Vitamin A palmitate 1 X 105 IU Vitamin D3 4 X 104 IU Sake essence (powder) 20 g Carboxymethylcellulose sodium 1.0 g Olive oil 5.0 g Glycerin monostearate 2.0 g Methyl p-hydroxybenzoate 0.025 g Buthyl p-hydroxybenzoate 0.015 g Purified water To make 100 g The above ingredients are blended by the conventional method to give an ointment. Example 2 Gel l-Menthol 1.5 g dl-Camphor 1.0 g Dipotassium glyzyrrhizinate 0.1 g LAUROMACROGOL 2.0 g Sake essence, 70 (W/V) percent 5.0 g Carboxyvinyl polymer 1.0 g Triethanolamine 1.5 g Ethanol 35 ml Purified water To make 100 g The above ingredients are blended in the conventional manner to give a gel. Example 3 Pack Polyvinyl alcohol 15 g Sake essence, 70 (W/V) percent 10 g Ethanol 10 ml Metyl p-hydroxybenzoate 0.028 g Butyl p-hydroxybenzoate 0.012 g Purified water To make 100 g The above ingredients are blended in the coventional manner to give a pack. Example 4 Cosmetic lotion Sake essence, 70 (W/V) percent 5.0 g Citric acid 0.5 g Polyoxyethylene oleyl ether 1.0 g Ethanol 10.0 ml Metyl p-hydroxybenzoate 0.028 g Butyl p-hydroxybenzoate 0.012 g Purified water To make 100 g The above ingredients are blended in the conventional manner to give a cosmetic lotion. Example 5 Cosmetic cream Squalane 10.0 g Isopropyl myristate 5.0 g White beeswax 3.0 g Stearyl alcohol 3.0 g Polyethylene glycol monostearate 2.0 g Glycerin monostearate 4.0 g Vitamin E acetate 0.2 g Sake essence (powder) 5.0 g Metyl p-hydroxybenzoate 0.2 g Butyl p-hydroxybenzoate 0.1 g Purified water To make 100 g The above ingredients are blended in the conventional manner to give a cosmetic cream.

Claims: What is claimed is: 1. A preparation for dermal use which contains sake essence as a moisture-retaining agent. 2. A preparation for dermal use as claimed in Claim 1, wherein the concentration of sake essence is 0.1-40 (W/V) percent on the sake essence solids basis.

Inventors: OGATA, KAZUMI, TSURUOKA, HIDEKI
Applicants: OGATA, KAZUMI, YOSHIDA, SHOJI
Application year: 1986
Main classification: A61K7
IPC codes: A61K8, A61Q19, A61K9, A61K47