PROCESS FOR PRODUCING IMINOCTADINE TRI-(ALKYLBENZENESULFONATES)

Abstract: A process for producing iminoctadine 3-alkyl­ benzenesulfonates, which comprises reacting triamine of the formula H₂N(CH₂)₈NH(CH₂)₈NH₂ with an O-alkylisourea alkylbenzenesulfonate in the presence or absence of a reaction medium.

Description: This invention relates to a process for producing iminoctadine tri(alkylbenzenesulfonates) (to be referred to as iminoctadine ABS salts) represented by the following formula which are among acid addition salts of 1,1'-iminodi(octamethylene)diguanidine (iminoctadine by ISO nomenclature; formerly called guazatine) useful as agricultural-horticultural fungicides but which have reduced phytotoxicity to useful plants, by reacting triamine of the formula H₂N(CH₂)₈NH(CH₂)₈NH₂ with O-alkylisourea alkylbenzenesulfonates (to be referred to as O-alkylisourea ABS salts). The present applicant previously filed applications for patent on water-insoluble acid addition salts of guanidine compounds in an attempt to eliminate or reduce the strong phytotoxicity to specific crops, which is the only defect of guanidine-type fungicides (European Patent 155,509; U.S. Patent 4,659,739; Canadian Patent 1,235,061; China 85101560; Taiwanese Patent 27,830; and Korean Patent 30,369). Iminoctadine ABS salts which come within these salts and have especially superior fungicidal efficacy and reduced phytotoxicity and toxicity can be produced by salt exchange of iminoctadine triacetate generally in practical use. The present inventor obtained a patent on a process for producing the iminoctadine triacetate (Japanese Patent Publication No. 35907/1982). Addition of a stoichiometrically excessive amount of an alkylbenzenesulfonic acid to an aqueous solution of iminoctadine triacetate liberates acetic acid. Since the resulting iminoctadine ABS salt is a water-insoluble viscous substance, acetic acid cannot be sufficiently removed even when the reaction product is concentrated to dryness. It may be possible to extract and wash the reaction product, but no suitable extractant is available. Even when sodium acetate is formed by using a sodium alkylbenzenesulfonate, a suitable extractant is not available and part of sodium acetate inevitably remains. Since the remaining acetate decreases the effect of alleviating phytotoxicity, these methods are not satisfactory. It might be possible on the other hand to use a method which comprises reacting iminoctadine triacetate with sodium carbonate to form guazatine sesquicarbonate having good crystallinity, washing it with water to remove sodium acetate completely, and then adding an alkylbenzenesulfonic acid. However, this method also requires a salt exchanging step, and the operation is troublesome. Particularly, when the method goes through the sesquicarbonate, the desired active components will be lost during filtration and washing of the sesquicarbonate. GB-A-1 294 443 describes a reaction of 1,17-di-amino-9-azaheptadecane with an O-alkylisourea derivate or an addition salt thereof to give the corresponding 1,17-diguanidino-9-azaheptadecane derivative. The present inventors have made extensive investigations in order to overcome these difficulties, and have now found that by using O-alkylisourea ABS salts hitherto unknown as a guanidinating agent for triamine, iminoctadine ABS salts are obtained in high yields by a simple operation. The present invention provides a process for producing iminoctadine tri(alkylbenzenesulfonates), characterized in that a solution of the O-alkylisourea C₄₋₁₈ alkylbenzenesulfonate in a reaction medium selected from water or a mixture of water and methanol is added dropwise at 20 to 30°C over the course of 1 to 10 hours to a solution of the triamine of the formula H₂N(CH₂)₈NH(CH₂)₈NH₂ in the reaction medium. The O-alkylisourea ABS salts used in this invention can be produced in quantitative yields from cyanamide, alkylbenzenesulfonic acids and lower alcohols such as methanol, ethanol or propanol. The amount of the O-alkylisourea ABS salt used in the process of this invention is generally 2 to 4 moles, preferably 2.06 to 2.40 moles, per mole of triamine. Preferred alkylbenzenesulfonic acids used in this invention are those having 1 to 20 carbon atoms, especially 4 to 18 carbon atoms, in the alkyl moiety. Dodecylbenzenesulfonic acid is especially preferred. Commercial dodecylbenzenesulfonic acid marketed as an industrial material can be preferably used in this invention since it is a mixture of alkylbenzenesulfonic acids in which the alkyl groups have 10 to 14 carbon atoms, mainly 12 carbon atoms. Water or a mixture of water and methanol is used as the reaction medium in the process of this invention. To inhibit the formation of by-products, the reaction is carried out by adding the solution of the O-alylisourea ABS salt in the reaction medium dropwise over the course of 1 to 10 hours to a solution of the triamine in the reaction medium. The reaction temperature is selected from the range of 20 to 30°C. At these reaction temperatures, the selectivity of the reaction is excellent. The reaction time varies depending upon the reaction temperature. The reaction is terminated within 10 hours after the addition, and the yield of the final product is 93 to 95 mole% based on triamine when O-methylisourea ABS salts are used. The O-alkylisourea ABS salts, whether the O-alkyl group is an O-methyl, ethyl or propyl group, i.e., O-C₁₋₃ alkylisourea ABS salts, are operable under the reaction conditions described above, but the yield of the final product decreases in the order of methyl, ethyl and propyl in the O-alkyl group. The iminoctadine ABS salt once formed is very stable, and prolongation of the reaction time would not adversely affect it. The outstanding feature of the present invention is that iminoctadine ABS salts having reduced phytotoxicity can be obtained in very high yields in one step from triamine. The following examples specifically illustrate the present invention. All percentages in these examples are by weight. EXAMPLE 1 Water (90.0 g) and 60.0g of methanol were added to 54.3g (0.196 mole) of 98% triamine, and with stirring, 266.6g (0.42 mole) of a 65.1% methanol solution of O-methylisourea dodecylbenzenesulfonate was added dropwise at 20 to 25°C over the course of 3 hours. After the addition, the mixture was stirred at 20 to 25°C for 10 hours. Then, 62.8g (0.2 equivalent) of dodecylbenzenesulfonic acid (acid value 178.7 mg KOH/g) was added, and the mixture was further stirred for 30 minutes. On standing, the mixture separated into two layers. The lower layer was taken, and analyzed by liquid chromatography. The analysis showed the formation of 247.8g of iminoctadine dodecylbenzenesulfonate. The yield was 94.7 mole% based on triamine. COMPARATIVE EXAMPLE 1 A 40% aqueous solution of O-methylisourea acetate (140.8g; 0.42 mole) was added to 54.3g (0.196 mole) of 98% triamine and 150.0 g of water, and the mixture was stirred at 20 to 25°C for 10 hours. Acetic acid (12.0g; 0.2 mole) was added, and the reaction mixture was analyzed by liquid chromatography. It was found that 99.8g of iminoctadine triacetate was formed in a yield of 95.0 mole% based on triamine. A 25% aqueous solution of sodium carbonate (508.8g; 1.2 moles) was stirred at 70 to 80°C, and the iminoctadine triacetate-containing reaction mixture obtained above was poured into the aqueous solution. The mixture was stirred for 30 minutes and then cooled to room temperature. The crystals precipitated were separated by filtration, and washed with water. Furthermore, 400g of water was added, and the mixture was stirred at 70 to 80°C for 30 minutes, and cooled to room temperature. The crystals were separated by filtration, washed with water, and dried overnight at 60°C to give 85.0g of a white powder. Liquid chromatography showed that the iminoctadine sesquicarbonate had a purity of 93.2%. By potentiometric titration, the equivalent weight of the guanidino group and the amino group was 388.6 mg KOH/g. Methanol (300 ml) was added to 85.0g of iminoctadine sesquicarbonate, and with stirring at 50°C, 184.9g of dodecylbenzenesulfonic acid (acid value 178.7 mg KOH/g) was added dropwise. The mixture was cooled to room temperature, and the reaction mixture was analyzed by liquid chromatography. It was found that 235.7g of iminoctadine dodecylbenzenesulfonate formed, and its yield based on triamine was 90.1 mole%.

Claims: A process for producing iminoctadine tri(alkylbenzenesulfonates), characterized in that a solution of an O-alkylisourea C₄₋₁₈ alkylbenzenesulfonate in a reaction medium selected from water or a mixture of water and methanol is added dropwise at 20 to 30°C over the course of 1 to 10 hours to a solution of the triamine of the formula H₂N(CH₂)₈NH(CH₂)₈NH₂ in the reaction medium. The process of claim 1 wherein the O-alkylisourea alkylbenzenesulfonate is an O-C₁₋₃ alkylisourea C₄₋₁₈ alkylbenzenesulfonate. The process of claim 1 wherein the O-alkylisourea alkylbenzenesulfonate is O-methylisourea dodecylbenzenesulfonate.

Inventors: ASADA, TOHRU, KATAOKA, YASUKI, MIURA, YASUHISA
Applicants: DAINIPPON INK AND CHEMICALS, INC.
Application year: 1986
Main classification: C07C279
IPC codes: C07C277, C07C279, A01N47, C07C67, C07C239, C07C309