THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE

Abstract: Thiazolidinedione derivatives of the formula: or pharmacologically acceptable salts thereof are novel com­ pounds, which exhibit in mammals blood sugar- and lipid-­ lowering activity, and are of value as a therapeutic agent for diabetes and therapeutic agent for hyperlipemia.

Description: Thiazolidin.edione Derivatives, Their Production and Use This invention relates -to novel thiazolidinedione derivatives, a method of preparing them and antidiabetic agents containing same, which is utilized in the field of medicines. A variety of:biguanide and sulfonylurea derivatives have been used clinically as antidiabetic agents. However, the biguanides are now scarecely used, because they t.end.to cause lactic acidosis, and use of the sulfonylureas, though they have strong hypoglycemic activities, requires sufficient precaution, because they cause serious-hypoglycemia frequently. Therefore, a new type of antidiabetic agent free from these defects has been desired. On the other hand, in Japanese Unexamined Patent Publication Nos 22636/1980 and 64586/1980, Chemical & BR< Pharmaceutical Bul.letin, 30, p. 3563 (1982), ibid, 30, p. 3580 (1982) , and ibid, 32, p. 2267 (1984) , reference is made to Åa variety of thiazolidinediones having blood glucose and lipid lowering actions. Antidiabetic activity of ciglitazone was also reported in Diabetes, 32, p. 804 (1983). Those compounds, however, have not yet been put to practical use. As the reasons, 1) insufficient activities or/and 2) serious toxicities may be mentioned. The present inventors synthesized various compounds which are not concretely described in the above-mentioned publications of unexamined patent applications and have made studies on them to find compounds exhibiting potent pharmacological effects with lower toxicity. The present invention is to provide compounds which can be used practically as antidiabetic agents having a broad safety margin between pharmacological effect and toxicity or unfavorable side reactions. The present invention relates to: 1. A compound of the formula: EMI2.1 or a pharmacologically acceptable salt thereof, 2. an antidiabetic agent, which contains as the effective component a compound of the formula (I) or a pharmacologically acceptable salt thereof, and 3. a method of preparing a compound of the formula (I) or a pharmacologically acceptable salt thereof, which comprises hydrolyzing a compound of the formula: EMI2.2 The compounds representable by the above formula (I) include, specifically stating, the following ones. 5-[4-[2-(3-ethyl-2-pyridyl)ethoxylbenzyll-2,4- thiazolidinedione, 5-[4-[2-(4-ethyl-2-pyridyl)ethoxy]benzyl]-2,4 thiazolidinedione, 5-[4-[2-(4-ethyl-2-pyridyl)ethoxy]benzyl]-2,4 thiazolidinedione, 5-[4-[2-(6-ethyl-2-pyridyl)ethoxy]benzyll-2,4- thiazolidinedione. The compound (I) of this invention contains both basic nitrogen and acid nitrogen in its molecule, and it can be led.to a pharmacologically acceptable salt, when desired, by using a suitable acid or base. Such-acid.salts are exemplified by mineral salts (e.g. hydroch.loride, hydrobromide, sulfate, etc.), organic acid salts (e.g. succinate, maleate, fumarate, malate, tartrate, etc.) and sulfonates (e.g. methanol sulfonate, benzenesulfonate, toluenesulfonate, etc.). Such basic salts are. exemplified by alkali metal salts e.g. sodium salt,- potassium salt, alkaline earth metal salts,e.g. calcium salt, etc. All of these salts can be prepared by per se known means. The compound (I) of this invention or a pharmacologically acceptable salt thereof exhibits bloodglucose and blood-lipid lowering action with lower toxicity, which can be used as it is or in admixture with á per se known pharmacologically acceptable carrier, excipient or filler as an antidiabetic agent for mammals including man. The antidiabetic agent is usually administered orally as tablets, capsules (including soft capsules and microcapsules), powders, granules, etc. and depending on the caset , parenterally as injections, suppositories, pellets, etc. Oral administration to an adult patient is desirably 0.05-10 mg/kg body weight/day, and parenterally 0.01-10 mg/kg body weight/day, once daily or divided into 2-4 times a week. The compound represented by the above mentioned general formula (I) and pharmacologically acceptable salts thereof [hereinafter collectively referred to as "Compound (I)] can be prepared by subjecting a compound represented by the general formula (11) to hydrolysis. This reaction proceeds advantageously in a proper solvent by employing a mineral acid. The solvent is exemplified by alcohols (e.g. methanol, ethanol, propanol, butanol, isobutanol, 2-methoxyethanol, etc.), dimethylsulfoxide, sulfolane, dioxane, tetrahydrofuran, dimethoxyethane, etc., and the mineral acid is exemplified by hydrochloric acid, hydrobromic acid, sulfuric acid, etc. The reaction temperature ranges from 200C to 1500C The reaction time is 0.5 - 20 hours. The compound (I) or a pharmacologically acceptable salt thereof produced as mentioned above can be isolated and purified by conventional means such as concentration; extraction, recrystallization, chromatography, etc. The compound represented by the above-mentioned general formula (II) can be produced by the following reactions: EMI4.1 EMI5.1 [wherein R stands for hydrogen or lower alkyl]. The lower alkyl group represented by R is exemplified by (C14) ones such as methyl, ethyl, propyl, isopropyl and butyl. The reaction.for producing compound (V) from compound (III) and compound (IV) is conducted in the presence of, for example, sodium hydride. This reaction can be carried out in a solvent e.g. dimethylformamide and tetrahydrofuran at a temperature ranging from -lO0C to 300C. The reaction from compound (V) to compound (VI) can easily be conducted by conventional catalytic reduction employing,for example, palladium-carbon as the catalyst. Compound (VI) may be isolated as the pure product or can be subjected to the subsequent reaction step without isolation and purification. Compound (VIII) can be produced by subjecting compound (VI) to diazotization in the presence of an aqueous solution of hydrobromic acid, then allowing the resultant to react with acrylic acid or its lower alkyl ester (VII) in the presence of a copper catalyst e.g. cuprous oxide, cupric oxide, cuprous chloride, cupric chloride, cuprous bromide, cupric bromide, etc. (Meerwein arylation). Compound (VIII) canbepurified by e.g. chromatography, and subjected to the subsequent reaction without isolation or purification. Compound (VIII) is then allowed to react with thiourea to give compound (II). This reaction is carried out usually in alcohols (e.g. methanol, ethanol, propanol, butanol, isobutanol, 2-methoxyethanol, etc.), dimethylsulfoxide, sulfolane, etc. The reaction temperature is usually 20 1800C,preferably 60 - 1500C. The amount of thiourea to be employed is 1- 2 moles relative to one mole of compound (VIII). In this reaction, as the reaction proceeds, hydrogen bromide is produced as a by-product, and, for capturing. this by-product, the reaction may be conducted in the presence of sodium acetate; potassium acetate, etc., in an amount of usually 1 - 1.5 mole relative to 1 mole of compound (VIII). The resultant compound (II) can be isolated, but may be led to the hydrolysis step directly without isolation: The compound (I) of the present invention has an excellent blood glucose and lipid lowering activity and is remarkably low in toxicity, which is supported by the following experimental data. Experimental Examples 1. Blood glucose and lipid lowering activity in mice To.male KKAY mice (8-1.0 weeks old, 5 mice/group), the test compounds (Åat three dosage levels) were given as a dietary admixture in CE-2 powdered diet (CLEA Japan) with free access to water for 4 days. Blood.samples were taken from the orbital vein on the 5th day. Blood glucose and plasma triglyceride (TG) were determined by a glucose oxidase method and by using a commercially available assay kit, Cleantech TG-S (matron, Japan), respectively. Based on dose-response curves for blood glucose and plasma TG lowering activity, the effective dose of each test compound in 25% decrease from the control value was calculated as the value of ED25 (mg/kg/day). The results are shown in Table 1. 2. Lipid lowering activity in rats Male Sprague-Dawley rats (7 weeks old, 5 rats/group) were maintained on the laboratory chow (CE-2, CLEA, Japan) with free access to water. All the test compounds (at three dosage levels) suspended in 5% gum arabic solution were forcedly administered to the animals orally for 4 days. Blood samples were taken from the tail vein on the 5th day. Plasma TG was determined using a commercially available assay kit, Cleantech TG-S (Iatron).. Based on dose-response curves for lipid lowering activity, the effective dose of each test compound in 25% decrease from the control value was calculated as the value of ED25 (mg/kg/day). The results are shown in Table 1. 3. Two-week toxicity study in rats Male and female Sprague-Dawley rats (5 weeks old, 5 rats/ group) were maintained on the laboratory chow (CE-2, CLEA Japan) with free access to water. All the test compounds suspended in 5% gum arabic solution were forcedly administered orally to the animals for:2 weeks once daily. The dose was 100 mg/kg/day for every test compound. The animals were sacrificed in about 20 hours of fasting after termination of the two-week administration by withdrawing blood samples from the abdominal aorta using heparinized syringes under ether anesthesia. The liver and heart were removed and weighed. Hematology analysis was also carried out using an automatic cell counter. The data represent 8 increase or decrease from the control value (non-drug treated) as shown in Table I Table 1 EMI9.1 EMI9.2 Co*- <SEP> Blood <tb> pound <SEP> A <SEP> Glucose <SEP> Two <SEP> weeks <SEP> toxicity <SEP> (rat, <SEP> %) <tb> <SEP> (ED25) <SEP> TG(ED25) <SEP> Liver <SEP> weight <SEP> Heart <SEP> weight <SEP> nu*ber <SEP> of <SEP> erythrocytes <tb> <SEP> *ouse <SEP> *ouse <SEP> rat <SEP> # <tb> (I) <SEP> C2H5#A-CH2CH2 <SEP> 6 <SEP> 6 <SEP> 3 <SEP> -0.7 <SEP> -3.5 <SEP> +0.9 <SEP> -3.9 <SEP> -3.4 <SEP> -0.7 <tb> <SEP> CH2 <tb> (a) <SEP> #CH2- <SEP> 40 <SEP> 40 <SEP> 70 <SEP> +6.6* <SEP> +10.8* <SEP> +18.4* <SEP> +4.0 <SEP> +3.5 <SEP> -0.2 <tb> <SEP> (giglitazone) <tb> (b) <SEP> CH2#N#CH2CH2- <SEP> 4 <SEP> 2 <SEP> 5 <SEP> +3.5 <SEP> +10.7** <SEP> +19.9** <SEP> +17.8** <SEP> -2.9 <SEP> -5.5** <tb> (c) <SEP> CH2#N#CH2CH2- <SEP> 20 <SEP> 20 <SEP> - <SEP> +1.8 <SEP> -1.2 <SEP> +7.2 <SEP> +8.0 <SEP> -4.2 <SEP> -5.0 <tb> <SEP> CH2 <tb> (d) <SEP> #CH2CH2- <SEP> 20 <SEP> 20 <SEP> - <SEP> +8.8* <SEP> +8.4** <SEP> +3.3 <SEP> +7.3* <SEP> -3.7 <SEP> -2.5 <tb> (e) <SEP> #CH2 <SEP> 20 <SEP> 20 <SEP> - <SEP> -2.8 <SEP> +6.6** <SEP> +10.9 <SEP> +9.8* <SEP> -8.7* <SEP> -7.0** <tb> <SEP> CH2CH2 t-test: mp < 0.05; mmp < 0.01 In Table 1, Compound (I) is a compound under the coverage of thepresent invention, compounds (a) and (b) are known compounds concretely referred to in the Japanese unexamined Patent Publication No.22636/1980. While coppounds (c), (d) and (e) are not concretely referred to in the above-mentioned patent publication, they are cited for comparison, since they are similar to compound (I) of this invention in their chemical structures. As is apparent from the experimental results given in Table 1, Compound (I) of this invention is superior to the compounds (a), (c), (d) and (e) and comparable to the compound (b) in hypoglycemic and hypolipidemic activities, while showing extremely low toxicity as compared with the compounds (a), (b), (d) and cue). Such an effect as above caused by the introduction of an ethyl group is quite unexpected. Thus, compound (I) of the present invention exhibits excellent hypoglycemic and hypolipidemic acivities, and little toxicity to internal organs and blood even by continuous administration for a long period of time. Therefor, compound (I) is of value as a therapeutic agent for Type II diabetes accompanied by obesity or hyperlipemia in mammals including man. Example 1 a) To a solution of 2-(5-ethyl-2-pyridyl)ethanol (53.0 g) and 4-fluoronitrobenzene (47.0 g) in DMF (500 ml) was added portionwise under ice-cooling 60% sodium hydride in oil (l6.0g). The mixture was stirred under ice-cooling for one hour then at room temperature for 30 minutes, poured into water and extracted with ether. The ether layer was washed with water and dried (MgS04). The solvent was evaporated off to give 4-[2-(5-ethyl-2 pyridyl)ethoxy]'nitrbenzene as crystals (62.0 g, 62.9%). Recrystallization from ether-hexane gave colorless prisms, m. p. 53-54 C. b) A solution of 4-[2-(5-ethyl-2-pyridyl)ethoxy]nitrobenze'ne (60.0 g) in methanol (500 ml) was hydrogenated at room tempera;ture under one atmospheric pressure in the presence of 10% Pd-C (50% wet, 6.0 g). The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The residual oil was dissolved in acetone (500 ml)-methanol (200 ml). To the solution was added a 47% HBr aqueous solution (152 g). The mixture was cooled, to which was added dropwise a solution of NaNO2 (17.3 g) in water (30 ml) at a temperature not higher than 50C. The whole mixture was stirred at 5 C for 20 minutes, then methyl acrylate (112 g) was added thereto and the temperature was raised to 38 C. Cyprous oxide (2.0 g) was added to the mixture in small portions with vigorous stirring. The reaction mixture was stirred until nitrogen gas evolution ceased, which was concentrated under reduced pressure. The concentrate was made alkaline with concentrated aqueous ammonia, and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried (MgSO4). The solvent was evaporated off to leave methyl 2-bromo-3-(4-[2- (5-ethyl-2- pyridyl) ethoxy]phenyl) propionate as a crude oil (74.09 g, 85.7%). IR(neat)cm-1:1735. NMR 6(ppm) in CDC13: 1.21 (3H,t,J=7), 2.60(2H,q,J=7), 3.0 - 3.6(4H,m), 3.66(3H,s), 4.30(2H,t,J=7), 4.3(lH,m),6.7 - 7.5(6H,m), 8.35(1H,d,J=2). c) A mixture of the crude oil of methyl 2-bromo-3 C4-[2-(5-etSlyl-2-pyridyl)ethoxy]phenyl) propionate (73.0 g) obtained in b) thiourea (14.2 g), sodium acetate (15.3 g) and ethanol (500 ml) was stirredfor 3 hours under reflux. The reaction mixture was concentrated under reduced pressure, and the concentratewastneutralized with a saturated aqueous solution of sodium hydrogencarbonate, to which were added water (200 ml) and ether (100 ml). The whole mixture was stirred for 10 minutes to yield 5-{4-t2-(5-ethyl-2-pyridyl)ethoxy]benzyli-2-imino-4- thiazolidinone as crystals (0.3 g, 523.0%). Recrystallization from methanol gave colorless prisms, m.p. 187-188 C (decomp.). Elemental analysis for C19H21N3O2S Calcd: C, 54.20; H, 5.95; N, 11.82. Found: C 64.20; H ,5.84; N .t1.73o d) A solution of 5-{4-[2-(5-ethyl-2-pyridyl) ethoxy]benzyl}-2-imino-4-thiazolidinone (23.5 g) in 2N HC1 (200 ml) was refluxed for 6 hours. The solvent was evaporated off under reduced pressure, and the residue was neutralized with a saturated aqueous solution of sodium hydrogencarbonate. . The crystals (23.5 g, 97.58) which precipitated were collected by filtration and recrystallized from D1F-H2O to give 5-{4-[2-(5-ethyl-2pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione as colorless needles (20.5 g, 86.9%), m.p. 183-1840C Elemental Analysis for C19H20N2 0 3S Calcd. C, 64.02; H, 5.66; N, 7.86. Found: C .63.70; H ,5.88; N, 8.01. e) To a suspension of 5-(4-[2-(5-ethyl-2-pyridyl) ethoxy]benzyl}-2,4-thiazolidinedione (356 mg) in methanol (10 ml) was added 28% sodium methylate/methanol solution (0.2 g) to make a solution. This solution was concentrated and diluted with ethyl ether to yield crystals. The crystals were collected by filtration an recrystallized from methanol-ethanol to give the sodium salt of 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione as colorless crystals (298 mg, 78.8%), m.p. 262-2630C (decep.). Elemental analysis for ClgHlgN2o3sNa: Calcd. : C,60.31; H,5.06; N,7.40 Found : C,60.20; H,5.07; N,7.52 Example 2 (19 5-{4-[2-(5-ethyl-2-pyridyl)-ethoxy]benzyl}-2,4 thiaz olidinedione 100 g (2) Lactose 50 g (3) Corn starch 15 g (4) Carboxymethyl cellulose calcium 44 g (5) Magnesium stearate Ig 210 g The whole amounts of (1), (2) and (3) and 30 g of (4) were kneaded with water and dried in vacuo, followed by granulation. With the resultant granules were mixed 14 g of (4) and 1 g of (5) and the whole mixture was tableted with a tableting machine to give 1000 tablets 8 mm in diameter and each containing 100 mg of (1). Reference Example 1 The compounds listed in Table 2 were prepared in accordance with Example l-a). Table 2 EMI15.1 EMI15.2 <tb> <SEP> R <SEP> mp <SEP> Recrystalization <SEP> solvent <SEP> yield <tb> 3-CH. <SEP> 1 <SEP> 1 <SEP> 1 <SEP> 6 <SEP> - <SEP> 1 <SEP> 1 <SEP> 7 <SEP> C <SEP> ethyl <SEP> acetate-hexane <SEP> 6 <SEP> 2. <SEP> 9 <SEP> 5 <SEP> <tb> 4-CH3 <SEP> 73 <SEP> - <SEP> 74 <SEP> C <SEP> ethyl <SEP> acetate-hexane <SEP> 57. <SEP> 3% <tb> 5-CH3 <SEP> 97 <SEP> - <SEP> 98 <SEP> C <SEP> ethyl <SEP> acetate-hexane <SEP> 72. <SEP> 3% <tb> Reference Example 2 In accordance with Example 1-b), the following compounds were prepared. Methyl 2-bromo-3-{4-[2-(3-methyl-2-pyridyl)ethoxy]phenyl} propionate; IR(Neat)cm-1: 1735. NMR #(ppm) in CDl3: 2.34(3H,s), 3.10(1H,dd, J=14 and 7), 3.25(2H1t,J=6), 3.38(1H,dd, J=14 and 7), 3.67(3H,s), 4.29(1H,t,J=7), 4.37(2H,t,J=6), 6.8-7.5(6H,m), 8.35(1H,dd, J=5 and 2). 2-Bromo-3-{4-[2-(4-methyl-2-pyridyl)ethoxy]phenyl} propidnic acid methyl ester; IR(Neat)cm-1: 1735. NMR 6(ppm) in CDC13: 2.30(3H,s), 3.10(1H, dd, J=14 and 7), 3.26(3H,t,J=7), 3.37(1H,dd, J=14 and 7), 3.67(3H,s), 4.30(3H,t,J=7), 6.7-7.36(6H,m), 8.37(1H,d,J=6) Reference Example 3 A solution of 4-f2-(5-methyl-2-pyridyl)ethoxy] nitro benzene (15.0 g) in methanol (150 ml) was subjected to catalytic reduction under 1 atmospheric pressure in the presence of 10% Pd-C (50% wet, 2.0 g). The catalyst was filtered off, and the filtrate was concentrated to give 4-f2-(5-methyl-2-pyridylethoxy]aniline as crystals (12.3 g, 92.5%). Recrystallization from ethyl acetate-hexane gave colorless prisms, m.p. 74-750C. Elemental analysis for C14H16N2O: Calcd.: C.73.66; H. 7.06; N. 12.27. Found: C.73.84; H. 7.17; N. 12.06. Reference Example 4 To a mixture of 4-[2-(5-methyl-2-pyridyl)ethoxy]aniline (12.0 g), 47% aqueous HBr solution (36.5 g) and methanol (40 ml)-acetone (80 ml) was added dropwise a solution of NaNO2 (4.0 g) in water (10 ml) at 50C or below. The whole mixture was stirred at 50C for 20 minutes, then methyl acrylate (27.0 g) was added thereto and the temperature was raised to 380C Cuprous oxide (1.0 g) was added to the mixture.in small portions with vigorous stirring. After nitrogen gas evolution had ceased, the reaction mixture was concentrated under reduced pressure. The concentrate was made alkaline with concentrated aqueous ammonia and extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried (MgS04). The solvent was evaporated off to leave methyl 2-bromo-3-f4-[2-(5-methyl- 2-pyridyl)ethoxy]phenyl}-propionate as a crude oil (17.5 g, 87.5%). IP(Neat)cm-1; 1735. NMR #(ppm) in CDC13: 2.27t3H,s), 3.10(1H,dd,J=14 and 7), 3.22(2H,t, J=6), 3.38(lH,dd,J=14 and 7),3.66(3H,s), 4.29(2H,t, J=6), 4.32(1H,t,J=7), 6.7-7.5(6H,m), 8.34(lH,d,J=2). Reference Example 5 The compounds listed in Table 3 were prepared in accordance with Example 1-c). Table 3 EMI18.1 EMI18.2 <tb> <SEP> R <SEP> mp <SEP> (decomp.) <SEP> Recrystalization <SEP> solvent <SEP> yield <tb> 3-CH3 <SEP> 280-231 C <SEP> chloroform-methanol <SEP> 75.5% <tb> 4-CH3 <SEP> 190-191 C <SEP> methanol <SEP> 48.0% <tb> 5-CH3 <SEP> 203-204 C <SEP> chloroform-methanol <SEP> 58.2% <tb> Reference Example 6 The compounds listed in Table 4 were prepared in accordance with Example l-d). Table 4 EMI18.3 EMI18.4 <tb> <SEP> R <SEP> mp <SEP> Recrystalization <SEP> solvent <SEP> yield <tb> 3-CH3 <SEP> 210-211 C <SEP> DNF-water <SEP> 65.7% <tb> 4-CH3 <SEP> 178-179 C <SEP> chloroform-methanol <SEP> 75.3% <tb> Reference Example 7 A mixture of 2-imino-5-I4-[2-(5-methyl-2-pyridyl) ethoxy)benzyl}-4-thiazolidinone (8.0 g), 2N HC1 (80 ml) and ethanol (80 ml) was refluxed for 16 hours. The reaction solution was neutralized with a saturated aqueous solution of sodium hydrogencarbonate to yield crystals. The crystals were collected by filtration and recrystallized from ethanol to give 5-(4-[2-(5-methyl-2 pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione as¯colorless prisms (7.0 g, 87.5%), m.p. 192-1930C, Elemental Analysis for C18H18N203: Calcd.: C,63.14: H,5.30; N,8.18 Found : C,63.22; H,5.40: N, 8.11

Claims: Claims: 1. A compound of the formula: EMI20.1 or pharmacologically acceptable salts thereof. 2. A compound as claimed in Claim 1, wherein the compound is 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy)benzyl}2,4-thiazolidinedione. 3. A compound as claimed in Claim 1, wherein theco- pound is a sodium salt of 5-f 4-(2-(5-ethyl-2-pyridyl)- ethoxy]benzyl}-2,4-thiazolidinedione. 4. An antidiabetic agent, which contains as the effective component a compound of the formula: EMI20.2 or a pharmacologically acceptable salt thereof. 5. A method of preparing a compound of the formula: EMI20.3 or a pharmacologically acceptable salt thereof, which comprises hydrolyzing a compound of the formula: EMI21.1 6. The use of a compound of the formula: EMI21.2 for the production ofa therapeutic agent for diabetes and therapeutic agent for hyperlipemia. AUSTRIAN CLAIMS 1. A compound of the formula: EMI22.1 or pharmacologically. acceptable salts thereof. 2. A method of preparing a compound of the formula: EMI22.2 or a pharmacologically acceptable salt thereof, which comprises hydrolyzing a compound of the formula: EMI22.3 3. A method of preparing a compound as claimed in Claim 2, wherein the compound is 5-t4-[2-(5-ethyl-2- pyridyl)ethoxylgbenzyl3-2,4-thiazolidinedione. 4. A method of preparing a compound as claimed in Claim 2, wherein the compound is a sodium salt of [2-(5-ethyl-2-pyridyl)-ethoxy]benzyl}-2,4-thiazolidinedione 5. An antidiabetic agent, which contains as the effective component a compound of the formula: EMI23.1 or a pharmacologically acceptable salt thereof. 6. The use of a compound of the formula: EMI23.2 for the production of a therapeutic agent for diabetes and therapeutic agent for hyperlipemia.

Inventors: FUJITA, TAKESHI, MEGURO, KANJI
Applicants: TAKEDA CHEMICAL INDUSTRIES, LTD.
Application year: 1986
Main classification: C07D417
IPC codes: A61K31, C07K14, A61P3, B23K35, A61K38, C07D417, C07D213