Microbiocidal compositions and processes for imparting microbiocidal properties to polymer compositions

Abstract: Microbiocidal solutions comprising an aryl alkanol sol­ vent such as benzylalcohol and a microbiocidal compound dis­ solved therein. The solutions may be used to impart micro­ biocidal properties to polymer compositions such as poly­ olefins, vinyl resins and polyurethanes. The preferred micro­ biocidal compounds are phenoxarsines such as 10,10′ oxy­ bisphenoxarsine.

Description: This invention relates to liquid microbiocidal solutions containing an aryl alkanol and a microbiocidal compound dissolved in said aryl alkanol. This invention also relates to compositions comprising a polymer processing aid and a microbiocidal compound dissolved in an aryl alkanol. The present invention further relates to a process for imparting microbiocidal properties to polymer compositions comprising adding to the polymer composition a liquid microbiocidal solution comprising an aryl alkanol and a microbiocidal compound dissolved therein. This invention also relates to a process for imparting microbiocidal properties to a polymer composition comprising adding to the polymer composition a composition comprising a polymer processing aid and a microbiocidal compound which is present in the polymer processing aid as the solute in an aryl alkanol solvent. It is presently common practice to protect polymer or plastic compositions from microbial, e.g. bacterial or fungal, attack by incorporating a microbiocidal composition into the polymer or plastic. The resulting polymer compositions prevent the deterioration of articles formed from the polymer compositions due to microbiological attack on the plasticizers or other polymer additives which are normally incorporated into the polymer to impart desirable physical properties to the article and to facilitate forming of the article. Many of the available microbiocidal materials are solid and, in order to incorporate them homogeneously in the polymer composition, it is necessary to first mix them with a liquid which solubilizes or disperses the material uniformly and thereafter, mix the thus-formed liquid composition with the polymer. Unfortunately, the solubility of many of the microbiologically active materials in the more common solvent materials is quite low. Therefore, it is either difficult to incorporate a sufficiently high concentration of the microbiocidal material with the polymer or, if sufficiently high concentrations of the microbiocidal material can be incorporated in the polymer an undesirably high concentration of the solvent must also be incorporated in the polymer with the resultant deterioration of the desirable characteristics of the polymer composition. Attempts to solve these problems have met with varying, often limited, success. For example, U.S. Patent No. 3,288,674 issued November 29, 1966 to Yeager and U.S. Patent No. 3,689,449 issued September 5, 1972 to Yeager and Wilson disclose the use of solvents having a labile hydrogen, preferably nonyl phenol, to dissolve microbiocidally active phenoxarsine compounds, the resulting solution being subsequently incorporated into resin compositions. Unfortunately, the solubility of the phenoxarsine in nonyl phenol plasticizer formulations is limited to low concentrations which necessitates incorporating nonyl phenol in the resin at higher concentrations than desirable in order to attain the desired phenoxarsine levels in the resin. U.S. Patent No. 3,360,431 issued December 1967 to Yeager discloses the use of liable hydrogen-containing solvents, preferably nonyl phenol, to dissolve microbiocidally active arsenobenzene compounds for subsequent addition to resin compositions. U.S. Patent No. 4,049,822 issued September 20, 1977 to Rei and Wilson discloses microbiocidal phenoxarsines dissolved in glycyl phosphites or glycyl phosphonates the resulting solution being subsequently incorporated into resin compositions. In accordance with the present invention there is provided a composition comprising a polymer processing aid, and an amount of 3 to 20% by weight, based on the total weight of the composition, of a microbiocidal compound selected from maleimides, isoindole dicarboximides having a sulfur atom bonded to the nitrogen atom of the dicarboximide group, isothiazolinone compounds phenoxarsines and phenarsazines said microbiocidal compound being present as the solute in an aryl alkanol solvent, and the aryl alkanol solvent being present in an amount such that the weight ratio of the aryl alkanol solvent to microbiocidal compound is from 0.5/1 to 5/1. Also provided in accordance with this invention is a process for imparting microbiocidal properties to a polymer composition which comprises adding to the polymer composition, in an amount sufficient to impart microbiocidal properties thereto, a microbiocidal composition as defined above. The content of microbiocidal compound in the microbiocidal composition is preferably at least 5 wt.%. There is also provided in accordance with the present invention a liquid microbiocidal solution comprising an aryl alkanol and a microbiocidal compound dissolved therein selected from maleimides, isoindole, dicarboxamides having a sulfur atom bonded to the nitrogen atom of the decarboxamide group and isothiazolinone compounds. There is further provided in accordance with this invention a composition comprising a polymer processing aid and, in an amount at least sufficient to impart microbiocidal properties to the composition, a microbiocidal compound selected from maleimides, isoindole dicarboxamides having a sulfur atom bonded to the nitrogen atom of the dicarboxamide group and isothiazolinone compounds which is present in the composition as the solute in an aryl alkanol solvent. Such compositions can be used for example plasticizing vinyl resins and imparting microbiocidal properties thereto. The aryl alkanol solvent and the microbiocide should between them constitute a liquid uniformly distributed in said plasticizer to form a single phase system. The aryl alkanols useful as solvents in the practice of this invention are compounds which have a hydroxyl group attached to an aromatic ring through an alkylene group. That is, the aryl alkanols of this invention contain an aromatic ring to which is attached a group having the formula―R―OH where R is a straight or branched-chain alkylene group, preferably having 1―6 carbon atoms, more preferably 1―3 carbon atoms and most preferably 1 carbon atom. The alkylene group may be unsubstituted or substituted with other groups such as, for example, halogens, amines, methyl, hydroxyl, or alkoxyl groups. The term aryl as used herein refers to aromatic rings which may be substituted with functional groups. Examples of such aromatic rings include benzene, naphthalene, and biphenyl rings. When the aryl group is substituted with functional groups, it may have any number of groups attached to the aromatic ring, it being required only that the type of functional groups, their position on the ring and/or their number does not interfere with the aryl alkanol's ability to dissolve the microbiocidal compound or, if it is to be employed as part of a polymer composition, its compatibility with the polymer. Examples of such functional groups on the aryl rings include halogen, aryloxy, amino, hydroxyl, alkoxyl, and nitro groups. The aryl alkanols useful in the practice of this invention may be further defined by the following general formula: wherein A is an aromatic ring, preferably benzene, which may be unsubstituted, e.g. phenyl, or substituted with one or more halo, aryloxy, amino, hydroxyl, alkoxyl or nitro groups; and R is a straight or branched chain alkylene group, preferably having 1―6 carbon atoms, which may be unsubstituted or substituted with halo, amino, methyl, hydroxyl or alkoxyl groups. The aryl alkanols which are useful in the practice of the present invention are those in which the hydroxyl group of the alkanol is a primary, secondary or tertiary alcohol. The preferred aryl alkanols are those in which the hydroxy group is a primary alcohol. Examples of aryl alcohols which may be employed in accordance with this invention include the following: benzyl alcohol styralyl alcohol (methyl benzyl alcohol) phenethyl alcohol 3-phenyl-1-propanol 2, 4-dichlorobenzyl alcohol m-phenoxy benzyl alcohol Of these aryl alkanols, benzyl alcohol, 2,4-dichlorobenzyl alcohol, and styralyl alcohol are preferred, benzyl alcohol being especially preferred. The aryl alkanols exemplified above are all liquids with the exception of 2,4-dichlorobenzyl alcohol, which is a solid. This compound has quite surprisingly been found to act as a solvent (or co-solvent) for those microbiocidal compounds which are liquids. If the 2,4-dichlorobenzyl alcohol is heated slightly it melts and then can be combined with the liquid microbiocidal compound to form a stable solution. A wide variety of microbiocidal compounds are useful in the practice of this invention. In general, the useful microbiocidal compounds possess microbiocidal activity and are soluble in an aryl alkanol. If the aryl alkanol/microbiocidal compound solution is to be employed in compositions containing polymer processing aids and/or polymers, the microbiocidal should be compatible with such processing aids or polymers. The types of microbiocidal compounds which may be employed in this invention are phenoxarsines (including bisphenoxarsines), phenarsazines (including bisphenarsazines), maleimides, isoindole dicarboximides, having a sulfur atom bonded to the nitrogen atom of the dicarboximide group and isothiazolinone compounds. The microbiocidal phenoxarsine and phenarsazine compounds useful in the compositions of this invention include compounds represented by the formulas: where X is halogen or thiocyanate, Y is oxygen or sulfur, Z is oxygen or nitrogen, R is halo or lower alkyl, and n is 0 to 3. Examples of these phenoxarsines and phenarsazines include 10-chlorophenoxarsine; 10-iodophenoxarsine; 10-bromophenoxarsine; 4-methyl-10-chlorophenoxarsine; 2-tert-butyl-10-chlorophenoxarsine; 1,4-dimethyl-10-chlorophenoxarsine; 2-methyl-8,10-dichlorophenoxarsine; 1,3,10-trichlorophenoxarsine; 2,6,10-trichlorophenoxarsine; 1,2,4,10-tetrachlorophenoxarsine; 10,10'-oxybisphenoxarsine (OBPA); 10-thiocyanato phenoxarsine; and 10,10'-thiobisphenoxarsine; 10,10'-oxybisphenarsazine and 10,10'-thiobisphenarsazine. The microbiocidal maleimide compounds useful in the compositions of this invention are exemplified by a preferred maleimide, N-(2-methylnaphthyl) maleimide. The microbiocidal compounds useful in the practice of this invention which are isoindole dicarboximides having a sulfur atom bonded to the nitrogen atom of the dicarboximide group are compounds which contain at least one group having the structure: The preferred isoindole dicarboximides are the following: bis-N-[(1,1,2,2-tetrachloroethyl)thio]-4-cyclohexene-1,2-dicarboximide N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide N-trichloromethylthio phthalimide An example of a preferred isothiazolinone compound useful in the composition of this invention is 2-n-octyl-4-isothiazolin-3-one. The most preferred microbiocidal compounds are the bisphenoxarsines and bisphenarsazines having the formula: where Y is oxygen or sulfur and Z is oxygen or nitrogen. Of these bisphenoxarsines and bisphenarsazines, the most preferred are 10,10'-oxybisphenoxarsine; 10,10'-thiobisphenoxarsine; 10,10'-oxybisphenarsazine; and 10,10'-thiobisphenarsazine. The microbiocidal compositions useful in this invention should be employed in an amount at least sufficient to impart microbiocidal properties to the composition or material containing them. This amount can vary widely depending upon the particular microbiocidal compound employed, the other components of the composition in which it is employed, the environment in which it will function and several other factors. The minimum amount of microbiocidal compound employed will be determined by what is known in the art as its Minimum Inhibitory Concentration (MIC). The maximum amount of microbiocidal compound which can be employed is determined only by the amount of microbiocidal compound which can be uniformly incorporated into a particular polymer composition without adversely affecting the physical properties of the composition. In general, the polymer compositions of this invention which possess microbiocidal properties contain from 50 parts per million (ppm) to 10,000 ppm, preferably 100 ppm to 500 ppm, of microbiocidal compound. The liquid microbiocidal solutions of this invention preferably contain much more microbiocidal compound than would be necessary simply to impart the desired microbiocidal properties to them. This is also true for the polymer processing aid-containing composition. These compositions can contain large amounts of microbiocidal compound since they are advantageously employed as "concentrates" to produce compositions which have a lower concentration of microbiocidal compound, but still have the desired degree of microbiocidal activity. For example, the liquid microbiocidal solutions may contain from 0.1 to 30 weight percent microbiocidal compound (based on total solution weight). However, a solution containing, for example, 25% microbiocidal compound may be used to prepare a polymer processing aid-containing composition which contains only 5% microbiocidal compound, which polymer processing aid-containing composition may in turn be used to prepare a polymer composition containing only 100 to 500 ppm microbiocidal compound. The microbiocidal solutions of this invention may be employed as additives for polymer compositions to impart microbiocidal properties to said polymer compositions. They may be added either directly to the polymer composition or they may be first incorporated into a polymer processing aid which serves as a carrier for incorporating the microbiocidal solutions into the polymer composition. When the latter manner is chosen, the polymer processing aids may be any of a variety of materials which are compatible with the polymer composition and microbiocidal solution (e.g. the microbiocidal compound does not precipitate or otherwise separate from the composition solution when used with the processing aid). Examples of these polymer processing aids include plasticizers, lubricants, and volatile and non-volatile solvents. Specific examples of these processing aids include typical plasticizers such as tricresyl phosphate, dipropylene glycol dibenzoate, diphenylcresyl phosphate, dipropylene glycol dibenzoate, diphenylcresyl phosphate, epoxidized soya, epoxidized tallate, dioctyl azelate, di(2-ethyl hexyl) phthalate, alkyl aryl phosphates, diisobutyl phthalate, diisodecyl phthalate, hydrogenated methyl rosin ester, n-octyl n-decyl phthalate, mixed n-alkyl phthalates, butyl benzyl phthalate, di-n-octyl phthalate, di-n-decyl phthalate, 3,4-epoxycyclohexyl methyl 3,4-epoxycyclohexane carboxylate, trioctyl trimellitate and low molecular weight polymeric plasticizers such as Paraplex G―30 plasticizer sold by Rohm & Haas Co. Of these plasticizers, di(2-ethyl hexyl) phthalate, diisodecyl phthalate, butyl benzyl phthalate and epoxidized soya are preferred. Other polymer processing aids useful in this invention include polypropylene glycol; 1,4-butanediol; silicone oils such as polydimethylsiloxane; and methyl ethyl ketone. As previously indicated, the concentration of microbiocidal compound in the microbiocidal solution may be sufficiently high that the polymer processing aid-containing composition prepared from said microbiocidal solution will in turn contain enough microbiocidal compound that, when the polymer processing aid-containing composition is added to a polymer, the ultimately-formed polymer composition and articles prepared therefrom will have microbiocidal properties. It is in this aspect of the invention where the solvents employed in the practice of the present invention are particularly advantageous. The aryl alkanols of this invention are capable of forming microbiocidal solutions which will produce polymer processing aid-containing compositions containing concentrations of microbiocidal compounds significantly higher than could be achieved with prior art solvents. For example, heretofore OBPA-containing plasticizing compositions contained a maximum of 2% by weight OBPA based on the weight of the plasticizing composition. It has now been quite unexpectedly found that the aryl alkanols of this invention are capable of producing OBPA-containing plasticizing compositions containing at least 5% by weight OBPA based on the weight of the plasticizing composition. This unexpected ability of the aryl alkanols to produce polymer processing aid-containing compositions containing high levels of microbiocidal compound leads to several very significant advantages. For example, shipping and handling cost savings are achieved because more "active ingredient" (the microbiocidal compound) can now be dissolved in a given amount of polymer processing aid-containing composition. Stated another way, for a given amount of microbiocidal compound, less "inert ingredients" (solvent and polymer processing aid) are required to produce a polymer processing aid-containing composition, resulting in raw material cost savings. Also, because less inert ingredients are needed, handling and shipping costs are lower. The polymer processing aid-containing compositions of this invention also minimize the potential effects of the solvent for the microbiocidal compounds on polymer formulations containing them. Because less solvent is required to prepare a polymer processing aid-containing composition containing a given level of microbiocidal compound, less solvent is introduced into the polymer formulation. Therefore, if the solvent is not entirely compatible with the other components of the polymer formulation, the negative effects of that incompatibility will be minimized. Apart from their ability to dissolve more microbiocidal compound, the aryl alkanols of this invention also have the surprising advantage of producing polymer processing aid-containing compositions which are low in odor and less irritating compared with the solvents disclosed in the prior art such as nonyl phenol and phosphites. It has also been quite surprisingly discovered that the microbiocidal solutions of the present invention can often be prepared at temperatures considerably lower than those required with the solvents of the prior art. For example, in order for nonyl phenol to dissolve OBPA, a nonyl phenol/OBPA mixture must generally be heated to 149°C (300°F). However, a benzyl alcohol/OBPA solution according to the present invention may be prepared by heating to only 60°C (140°F). Obviously, when large masses of material are required to be heated, as in a commercial operation, the lower temperature requirement of the microbiocidal solutions of this invention can result in tremendous energy savings. The lower temperature also helps prevent undesirable chemical reactions (such as the oxidation of benzyl alcohol to benzaldehyde) from occurring. The polymers employed in the processes and products of this invention cover a wide variety of materials. In general, they include thermoplastic and thermosetting polymers, elastomers and other materials commonly known as "plastics". Other organic materials, for instance naturally occurring materials such as natural rubbers and cellulose are considered full equivalents of the "polymers" of this invention and should be included within that term. Examples of the polymers useful in the practice of this invention include vinyl resins (such as those made from vinyl chloride and/or vinyl esters) polyolefins (such as polyethylene and polypropylene), elastomeric polyurethanes nylon, polystyrene, polyesters (such as polyethylene terephthalate), polycarbonates, acrylonitrile-butadiene-styrene (ABS) copolymers, SBR rubbers, styrene-acrylonitrile copolymers, acrylic polymers, thermosetting polyurethanes (such as those used for foams and coatings), phenolic resins, silicone rubbers, natural rubber, EDPM polymers, cellulose and its derivatives, epoxy resins and various latexes. The microbiocidal solutions of this invention can be prepared by simply adding the desired amount of microbiocidal compound to the aryl alkanol solvent, heating the resulting mixture to a temperature which will cause the microbiocidal compound to dissolve, and maintaining that temperature until all of the microbiocidal compound dissolves. The resulting solution can then be cooled to room temperature. In this manner, stable microbiocidal solutions, i.e. those wherein no significant amount of microbiocidal compound precipitates from the solution upon cooling to room temperature, can be formed containing up to about 30% by weight microbiocidal compound based on the weight of the resulting microbiocidal solution. The polymer processing aid-containing compositions of the present invention may be prepared by merely adding the polymer processing aid to a microbiocidal solution prepared as described above and mixing at room temperature until a uniform solution results. Alternatively, all ingredients of the polymer processing aid-containing composition (microbiocidal compound, aryl alkanol and polymer processing aid) can be mixed together and heated until the microbiocidal compound dissolves. The microbiocidal solutions of this invention can be used to impart microbiocidal properties to polymer compositions. This can be done by simply adding the microbiocidal solution, either alone or as part of a polymer processing aid-containing composition, to the polymer composition by any of several convenient methods known in the art. Thus, for instance, the polymer composition can be melted and the microbiocidal solution or polymer processing aid-containing composition added to and mixed with it (as in an extruder). Alternatively, the polymer can be softened with or dissolved in a solvent and the microbiocidal solution or polymer processing aid-containing composition added to and mixed therewith. The compositions of this invention will now be further described by reference to several embodiments thereof which are summarized in the following Table A. In these embodiments, all percentages are by weight based on the total weight of the composition. Also, for the purposes of Table A, the microbiocidal compounds have been divided into two classes designated "OBPA" and "non-OBPA". "OBPA" refers to the phenoxarsine and phenarsazine compounds described elsewhere herein which are preferred in the practice of this invention. The terms "non-OBPA" refers to all the other classes of microbiocidal compounds. Microbiocidal Cmpd. dissolved in aryl alkanol Amount of Microbiocidal Compound Polymer Processing Aid Wt. Ratio of aryl alkanol/microb. cmpd. non-OBPA Microbiocidal amnt. - - non-OBPA 0.1-30% - - OBPA >2% Plasticizer 0.5/1-5/1 OBPA >5% do 0.5/1-5/1 OBPA 5% do 4/1 OBPA 5% do 3/1 OBPA 5-20% do 3/1-5/1 non-OBPA Microbiocidal amnt. do - non-OBPA Microbiocidal amnt. do 0.5/1-5/1 non-OBPA Microbiocidal amnt. do 0.5/1-3/1 non-OBPA Microbiocidal amnt. do 1/1-3/1 non-OBPA >2% do - non-OBPA >2% do 0.5/1-5/1 non-OBPA >5% do 0.5/1-5/1 non-OBPA 5-20% do 3/1-5/1 The following examples illustrate the present invention. As used in the examples and throughout this specification, all parts and percentages are by weight unless otherwise indicated. Example 1 Several microbiocidal solutions were prepared by mixing the microbiocidal compounds and solvents indicated in Table I and heating the resulting mixtures at the temperatures indicated in Table I until they became clear. (The numbers in parentheses indicate the weight percent of each ingredient based on solution weight). The resulting clear solutions were then cooled to room temperature and aged at room temperature (RT) for varying periods of time, after which they were examined to determine whether the microbiocidal compound was still in solution. Example 2 Polymer processing aid-containing compositions were prepared by first preparing a solution of microbiocidal compound in an aryl alkanol solvent as described in the foregoing examples, blending the thusformed solution with a polymer processing aid and heating the blend while stirring until thoroughly mixed. Several polymer processing aid-containing compositions were prepared in this manner using the ingredients and conditions indicated in Table II with the results also indicated in Table II. All percentages in Table II are by weight percent based on the total weight of the compositions. Solution No. Microbiocidal Compound Solvent Temp. (°C) RT F OBPA (28.6%) benzyl alcohol (71.4%) (93°C) S S K OBPA (27.0%) benzyl alcohol (73.0%) do do I OBPA (25.0%) benzyl alcohol (75.0%) do do J OBPA (20.0%) benzyl alcohol (80.0%) do do 1 OBPA (20.0%) styralyl alcohol (80.0%) (71-104°C) S S 2 OBPA (20.0%) phenethyl alcohol (80.0%) do do 3 OBPA (20.0%) 3-phenyl-1-propanol (80.0%) do do 5 OBPA (20.0%) m-phenoxy benzyl alcohol (80.0%) do do 7 OBPA (20.0%) benzyl alcohol (80.0%) do do A RH-893® (10.0%) benzyl alcohol (90.0%) do do B ATV-129® (10.0%) benzyl alcohol (90.0%) do do D Vancide 89® (10.0%) benzyl alcohol (90.0%) do do H OBPA (10.0%) benzyl alcohol (90.0%) do do Solubility Solution No. After 24 Hours RT After 7 Days RT After 1 Mo. RT F - S - K - S - I - S - J - S - 1 S - MP 2 S - S 3 S - S 5 S - S 7 S - S A S S - B SP SP - D SP SP - H S S - Example 3 Several of the compositions shown in Table I and Table II were subjected to aging (storage stability) tests by aging the sample at room temperature for seven days, after which they were subjected to five freeze-thaw cycles. Each freeze-thaw (F―T) cycle consisted of storing the sample in a freezer at -17.8°C (0°F) for two days followed by one day at room temperature. After five of these cycles the samples were examined for stability with the following results: Solution or Plasticizing Comp'n No. Stability after 7 days RT Stability after 5 F-T cycles F Stable Not Stable K Stable Not Stable I Stable Stable J Stable Stable 58 thru 78 Stable Stable It should be emphasized that those compositions in Table III which were not stable after the F―T cycles are still quite useful in the practice of this invention. For instance, they can be used to prepare polymer processing aid-containing compositions which are stable after F―T cycles, or can be stored and used under conditions which avoid F―T cycles. Additional stability tests were conducted to determine the effects on solution stability when the weight ratio of aryl alkanol to microbiocidal compound and the type of polymer processing aid is varied. These tests were performed by first preparing a concentrated solution of the microbiocidal compound (OBPA) in the aryl alkanol (benzyl alcohol) by heating a mixture of the two materials to 71°C (160°F) until a clear solution results. Immediately after preparation of the concentrated solution, a polymer processing aid-containing solution was prepared by diluting the concentrated aryl alkanol/microbiocidal compound solution with a polymer processing aid at room temperature. The resulting composition was then stored in a glass vial at room temperature and the solution stability was recorded after 24 hours and after 7 days aging. A composition was considered to fail after the first signs of microbiocidal compound precipitation or liquid phase separation. After 7 days at room temperature, the solutions were subjected to 5 freeze-thaw (F―T) cycles at -17.8°C (0°F). A cycle consisted of storing the sample for 2 days in a freezer (at -17.8°C (0°F)) followed by one day at room temperature. The results of these stability tests are summarised in Table IV where all percentages are by weight based on total composition weight. The data in Table IV demonstrate that a weight ratio of benzyl alcohol to OBPA of about 3/1 has the best overall solution stability in the various plasticizers tested. A benzyl alcohol to OBPA weight ratio of about 2/1 also exhibited excellent stability in the solutions with lower OBPA levels. When the benzyl alcohol/OBPA weight ratio was about 1/1, solutions having lower levels of OBPA were more stable than those at higher levels. The data also indicates that high levels of silicone oil can cause unstable solutions, and, therefore, when this polymer processing aid is employed it should be used at low levels. Mineral spirits, while providing acceptable stability, would not be a preferred polymer processing aid where freeze-thaw stability is critical. Example 5 Compositions W―6 through W―36 from Table II were also subjected to heat stability tests by adding the composition to a poly (vinyl chloride) plastisol in an amount such that the resulting composition contained 5% by weight plasticizing composition, and forming a film from the resulting composition. This film was then divided into several samples and placed in an oven at about 177°C. Samples were then removed from the oven at five minute intervals for 40 minutes and examined for heat stability. All of the films tested were heat stable. Example 6 A typical plasticizing composition according to this invention was tested to determine whether the aryl alkanol solvent contained therein had any adverse effect when the plasticizing composition is employed in a vinyl resin. The plasticizing composition was prepared by heating the following ingredients to 160°C. Plasticizing Composition Ingredients Wt % OBPA 3.41 Benzyl alcohol 5.50 DIDP plasticizer 91.09 This plasticizing composition was incorporated into a typical plasticized poly (vinyl chloride) dry blend formulation which contained the following. PVC Dry Blend Formulation Ingredient Amount (gms) PVC 1500.0 DOP plasticizer 600.0 Heat stabilizer 90.0 Stearic acid lubricant 3.75 Total 2,193.75 gms The plasticizing composition was used in an amount so that the OBPA was present in the PVC dry blend formulation at the recommended level of about 500 parts per million. The resulting PVC dry blend containing the plasticizing composition was processed on a two-roll mill for approximately 15 minutes at 163°C. During this time, the molten plastic was observed for heat stability, processing characteristics, excessive fuming of the benzyl alcohol, and irritation to the mill operator. No unusual processing difficulties, such as sticking to the mill or failure to flux or form a sheet on the hot rollers, were observed. The formulation showed no signs of degradation or excessive fuming. No irritation or odor was observed during processing. Thus, this example demonstrates that benzyl alcohol does not adversely affect the processing of typical plastic materials. Example 7 Antimicrobial efficacy was tested by preparing PVC films as described in Example 5 which contained a polymer processing aid-containing composition according to this invention which contained the following ingredients: Plasticizing Composition Ingredient Wt % OBPA 3.41 Benzyl alcohol 5.50 DIDP 91.09 A control was also made in like manner, except that it contained no antimicrobial compound. Round samples (1 inch or 2.54 cm diameter) were cut from the PVC film samples. These round samples were then placed on a glass plate or petri dish which was previously coated with agar, innoculated with the test microorganism, and placed in an incubator under conditions and for a period of time which would normally permit the microorganism to grow on untreated agar. The dish or plate was then removed and examined for growth of the microorganism on the PVC sample. The results of the above tests are summarized below. The term "Zone of Inhibition" refers the width of an area (measured in millimeters) around the round PVC sample in which no microorganism growth occurred on the agar. The "Growth" or "Stain" observations refer to the presence of microorganism growth or stain on the round sample (also called the "contact area"). Zone of Inhibition (mm)/Growth for Staph. Aureus Sample With plasticizing composition 8/NGCA Control 0/GCA Zone of Inhibition (mm)/Growth for K. Pneumoniae Sample With plasticizing composition 4/NGCA Control 0/GCA Zone of Inhibition (mm)/Stain for Pink Stain Sample With plasticizing composition 6/NS Control 0/HS Zone of Inhibition (mm)/Growth for Mixed Fungal Spore Sample With plasticizing composition 15/NG Control 0/TG NGCA = No Growth in Contact Area GCA = Growth in Contact Area NS = No Stain MS = Moderate Stain HS = Heavy Stain NG = No Growth TG = Trace Growth LG = Light Growth The above data shows that the polymer processing aid-containing composition is effective in preventing the growth of microorganisms on the PVC film.

Claims: A composition comprising a polymer processing aid, and an amount of 3 to 20% by weight, based on the total weight of the composition, of a microbiocidal compound selected from maleimides, isoindole dicarboximides having a sulfur atom bonded to the nitrogen atom of the dicarboximide group, isothiazolinone compounds, phenoxarsines and phenarsazines, said microbiocidal compound being present as the solute in an aryl alkanol solvent, and the aryl alkanol solvent being present in an amount such that the weight ratio of the aryl alkanol solvent to microbiocidal compound is from 0.5/1 to 5/1. A composition according to claim 1 wherein the polymer processing aid is a plasticizer or a solvent. A composition according to claim 2 wherein the processing aid is a plasticizer selected from di(2-ethyl hexyl)phthalate, diisodecyl phthalate, butyl benzyl phthalate and epoxidized soya. A composition according to any preceding claim wherein the microbiocidal compound is present in an amount of at least 5% by weight. A composition according to any preceding claim, wherein the microbiocidal compound is selected from N-(2-methylnaphthyl) maleimide; bis-N-(1,1,2,2-tetrachloroethyl)thio)-4-cyclohexene-1,2-di-carboximide; N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide; N-trichloromethylthio phthalimide; and 2-n-Octyl-4-isothiazolin-3-one. A composition according to any one of claims 1 to 4 wherein the microbiocidal compound is selected from 10,10'-oxybisphenoxarsine; 10,10'-thiobisphenoxarsine; 10,10'-oxybisphenarsazine and 10,10'-thiobisphenarsazine. A composition according to claim 6 wherein the microbiocidal compound is 10,10'-oxybisphenoxarsine. A composition according to any preceding claim wherein the aryl alkanol is benzyl alcohol. A composition according to any preceding claim wherein the weight ratio of the aryl alkanol to the microbiocidal compound is from 0.5/1 to 3/1. A composition according to any one of claims 1 to 8 wherein the weight ratio of the aryl alkanol to the microbiocidal compound is 3/1 to 5/1. A process for imparting microbiocidal properties to a polymer composition comprising adding to the polymer composition, in an amount at least sufficient to impart microbiocidal properties thereto, a microbiocidal composition according to any preceding claim. A process according to claim 11 wherein the microbiocidal composition is added in an amount sufficient to include 50 to 10,000 ppm of microbiocidal compound in the polymer composition. A process according to claim 11 or claim 12 wherein the polymer is selected from polyolefins, vinyl resins and polyurethanes. A liquid microbiocidal solution comprising an aryl alkanol and a microbiocidal compound dissolved therein selected from maleimides, isoindole dicarboxamides having a sulfur atom bonded to the nitrogen atom of the dicarboxamide group and isothiazolinone compounds. A microbiocidal solution according to claim 14 which comprises 0.1 to 30 weight percent microbiocidal compound, based on the total weight of the solution. A composition comprising a polymer processing aid and, in an amount at least sufficient to impart microbiocidal properties to the composition, a microbiocidal compound selected from maleimides, isoindole dicarboxamides having a sulfur atom bonded to the nitrogen atom of the dicarboxamide group and isothiazolinone compounds which is present in the composition as the solute in an aryl alkanol solvent. A composition according to claim 16, which comprises at least 3% by weight, based on the total weight of the composition of the microbiocidal compound. A composition according to claim 17 which comprises at least 5% by weight, based on the total weight of the composition, of the microbiocidal compound. A process for imparting microbiocidal properties to a polymer composition comprising adding to the polymer composition a liquid microbiocidal solution comprising an aryl alkanol and, in an amount sufficient to impart microbiocidal properties to the polymer composition, a microbiocidal compound selected from maleimides, isoindole dicarboxamides having a sulfur atom bonded to the nitrogen atom of the dicarboxamide group and isothiazolinone compounds dissolved in the aryl alkanol. A process for imparting microbiocidal properties to a polymer composition comprising adding to the polymer composition a composition comprising a polymer processing aid and, in an amount at least sufficient to impart microbiocidal properties to the polymer composition, a microbiocidal compound selected from maleimides, isoindole dicarboxamides having a sulfur atom bonded to the nitrogen atom of the dicarboxamide group and isothiazolinone compounds which is present in the polymer processing aid as the solute in an aryl alkanol solvent.

Inventors: REI NUNO M, WILSON RONALD C, REI, NUNO M., WILSON, RONALD C.
Applicants: THIOKOL MORTON INC, MORTON THIOKOL, INC.
Application year: 1985
Main classification: A01N25
IPC codes: A01N25, A01N31, A01N43, A01N47, C08K5