THERAPEUTIC PREPARATIONS FOR TREATMENT OF CERTAIN VIRAL AND OTHER DISEASES AND THE PREPARATION OF THE SAME

Abstract: Therapeutic preparations against certain viral and other diseases of humans. The preparations are specified as formulas containing attenuated Newcastle disease virus, Marek's disease virus, avian bronchitis virus or avian encephalitis virus, mixed in carrier substance generally used in human pharmacology, if desired along with one or more optional potentiating preparations. Another object of the invention is the use of the above viruses in the treatment of virus diseases as well as malignant and benign tumours and collagen diseases.

Description: THE EPAUTIC PREPARATIONS FOR TREATMENT OF CERTAIN VIRAL θ OTTER DISEASES JWD " ϋ€ PREPARATION OF THE SAME Technical field The present invention relates to a set of therapeutic preparations (further on Preparation (s ) ) for the treatment of certain viral and other diseases , together with the complete technics of their production , including all materials and methods used. The Preparations are effective against various patholog¬ ical conditions caused by the Herpes group of viruses , and against certain malignant and benign tumours and collagen diseases as well. Background art Inactivated or live attenuated viruses have long been used all over the world for the specific prevention of several viral diseases of humans and animals. We have found that certain attenuated viral vaccines , pre pared against some viral diseases of animals (Newcastle disease , Marek 's disease , avian bronchitis , avian encephalitis ) had a distinct therapeutic effect against various human diseases of known viral or unknown etiology. Disclosure of invention Accordingly the ob ject of the present invention is a set of preparations containing attenuated (or killed) Newcastle disease virus , Marek's disease virus , avian bronchitis virus or avian encephalitis virus , mixed in a carrier which is acceptable for use in humans. The present invention relates also to all materials and methods used in the production of all preparations. The Preparations have alread been used with very good result in the conditions listed below: 1. The Preparation containing attenuated Newcastle disease virus was active against the followin g conditions : a) Infections caused by viruses of the Herpes group , such as Herpex simplex I and II , Herpes zooster, Cytomegalovirus , infectious mononυcleoses (Epstein- Barr virus ) b) Aphthostomatitis c) Verruca vulgaris d) Infantile pharyngeal papilloma e) Human aden oca rein omas f ) Collagen diseases (e. g. nodous polyarteritis) g) Rheumatic arthritis 2. The Preparation containing attenuated Marek's disease virus acted against the following conditions': a ) Various human cancers (mainly a den oca rein omas ) b) Infections caused by viruses of the Herpes group as listed above (l.a) 3. The Prepa ration containing attenuated avian bronchitis virus was active against the following conditions : a) Various human cancers b) Infections caused by the above listed (l.a) viruses of the Herpes goup. 4. The Preparation containing attenuated avian encephalitis virus was active against the following conditions : a) Various human cancers While most vaccines used for specific disease prevention in humans contain killed (inactivated) virus , all Preparations contain live attenuated virus. The possible mechanism of action of the Preparations is thus either an " interference with the virulent viruses responsible for the actual disease , or a highly efficient aspecific stimulation of the natural protectiv mechanisms operative in the organism involved by disease. The Preparations are produced by suspending live attenuated or inactivated , purified or highly purified and concentrated viruses in one of the carrier substances generally used in human pharmacology. The Preparations may be supplemented with potentiating drugs (e.g. tranquilizers). The optimal form of delivery of the Preparations is in a freeze-dried form , in sealed ampoules , with the diluent supplied in a separate vial. In this form , the Preparations can be stored at room temperature for a practically unlimited time, toother forms of delivery are in solution , suppository , capsule , emulsion , suspension , ointment , etc. These should be stored in cold , for their activity may decay repidly at room temperature. The dosage of the Preparations depends of their actual composition and form , on the patient 's general condition , and on stage (severity) of the disease actually treated. The Preparations are non-toxic , and have no side effect whatever. The Preparations were tested in humans and animals , and showed a great therapeutic efficiency in both clinical and experimental trials.

Claims: Claims 1. Therapeutic preparation for the treatment of viral diseases and against malignant and benign tumours and collagen diseases characterized by containing live attenuated viruses selected from the group consisting of Newcastle disease virus , Marek's disease virus , avian bronchitis virus and avian encephalitis virus. 2. The preparation according to claim 1 characterized by containing at least one carrier. 3. Use of Newcastle disease virus , Marek's disease virus , avian bronchitis virus and avian encephalitis virus in the treatment of viral diseases , against malignant and benign tumours and collagen diseases. 4. The use of viruses according to claim 3 in the treatment of diseases caused by the Herpes group of viruses.

Inventors: CSATARY LASZLO, CSATARY, LASZLO
Applicants: CSATARY LASZLO, CSATARY, LASZLO
Application year: 1985
Main classification: A61K39
IPC codes: A61K35, A61K39