SUBSTITUTED DIHYDROQUINOLONE CARBOXYLIC ACIDS, ANTI-BACTERIAL COMPOSITIONS CONTAINING THEM

Abstract: 1-Substituted-6-fluoro-7-aryl-(8-fluoro)-1,4-dihydro­ quinol-4-one 3-carboxylic acids having antibacterial activity. They may be prepared by reacting the corresponding alkyl 1-substituted-6-fluoro-7-bromo-(8-fluoro)-1,4-dihydroquinol-­ 4-one-3-carboxylate with an arylmetallic compound and hydrolyzing the ester formed.

Description: SUBSTITUTED DIHYDROQUINOLONE CARBOXYLIC ACIDS ANTI-BACTERIAL COMPOSITIONS CONTAINING TEEM This invention relates to l-substituted-6-fluoro 7-aryl-(8-fluoro)-1,4-dihydro-quinol-4-one 3-carboxylic acids and their esters and cation salts", their preparation, and antibacterial compositions containing these compounds. Since the introduction of nalidixic acids in 1963, a considerable number of patents and scientific papers have been published on analogs of this compound. Representative of these publications is U.S. Patent No. 3,472,859 granted October 14, 1969 disclosing inter alia compounds of the following formula EMI1.1 wherein R is lower alkyl. Example 7 of the patent dis- closes fungi static activity for the compound wherein R is methyl, but no antibacterial data are provided. The compounds of the present invention are 1,4 dihydroquinol-4-one-3-carboxylic acids of the formula EMI1.2 wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms, benzyl or a pharmaceutically acceptable cation; R2 is hydrogen or fluoro; Y is alkyl, haloalkyl or polyhaloalkyl of 1 to 3 carbon atoms, hydroxyethyl, cyclopropyl, vinyl, allyl, phenyl, 4-hydroxyphenyl or 4-fluorophenyl; Rz and Y when taken together have the formula X(CH2)nCHR4 4 EMI2.1 wherein X is CH2, O, S, NH or NCH3, n is O, 1 or 2, and R4 is hydrogen, alkyl or haloalkyl cf 1 to 3 carbons, hydroxymethyl, hydroxyethyl, aminomethyl, or phenyl, and X is attached to the phenyl of the quinoline group; and R3 is phenyl which may be substituted by one to three substituents selected from alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylmercapto of 1 to 4 carbon atoms, alkylsulfinyl of I to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, fluoro, chloro, trihalomethyl, hydroxy, hydroxyalkyl of 1 to 3 carbon atoms, amino, alkylamino of 1 to 4 carbon atoms, dialkylamino of 2 to 8 carbon atoms, aminoalkyl of 1 to 3 carbon atoms, alkylaminoalkyl of 2 to 8 carbon atoms, dialkyl-aminoalkyl of 3 to 9 carbon atoms, formamido, dialkylformamido of 2 to 8 carbon atoms, alkanovl- amino of 2 or 3 carbon atoms, formamidino, aminosulfonyl, alkylaminosulfonyl of 1 to 4 carbon atoms, dialkvlaminosulfonyl of 2 to 8 carbon atoms, nitro, formyl, alkanoyloxy of 1 to 4 carbon atoms, ureido, alkylsul fonylamido of 1 to 4 carbon atoms, cyano, carboxamido, azidomethyl, carboxy and alkylsilyloxymethyl of 4 to 13 carbon atoms; with the proviso that Rq is not methyl, when R3 is phenyl or phenyl substituted by one or two substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, alkylamino, alkanoylamino and formamido, and Z is CH2, O or NCH3. Preferred compounds of the invention are those wherein R3 is phenyl which may be monosubstituted at the 2, 3 or 4 position by a substituent selected hydroxy, hydroxymethyl, methoxy, amino, methylamino, aminomethyl, carboxy, formamido, nitro, aminosulfonyl, methylsulfinyl, methylsulfonyl, acetylamido, N- (N' ,N'- dimethylformamidino), cyano and formyl. R3 may in addition be substituted in any one of the unsubstituted positions by a substituent selected from fluoro, chlor'a, methyl, ht H5yl, amicmeiv1, carboxy, hydroxy, methoxy, methylthio, methylsulfinyl, methylsulfonyl, amino, methylamino, dimethylamino, nitro, carboxamido, aminosulfonyl, cyano and formyl. Other preferred compounds are those wherein Rl is hydrogen, or a pharmaceutically acceptable cation, and those wherein Y is ethyl. Specific preferred compounds of the invention in which R2 is fluorine are 6,8-difluoro-7-phenyl-1-ethyl-1,4-dihydroquinol-4- one 3-carboxylic acid 6,8-difluoro-7-(4-hydroxyphenyl)-l-ethyl-1,4- dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-carboxyphenyl)-1-ethyl-1,4dihydroquinol-4-one 3-carboxylic acid. 6,8-difluoro-7-(3-chloro-4-hydroxyphenyl)-l-ethyl 1,4-dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(3-hydroxyphenyl)-1-ethyl-1,4dihydro-quinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-aminomethylphenyl)-l-ethyl-1,4- dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(3-aminomethylphenyl)-1-ethyl-1,4 dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-hydroxymethylphenyl)-1-ethyl- 1,4-dihydroquinol-4-one 3-carboxylic acid 6, 8-difluoro-7- (3-hydroxymethylphenyl) -1-ethyl- 1,4-dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-methylsulfinylphenyl)-l-ethyl1,4-dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-methoxyphenyl)-l-ethyl-1,4- dihydro-quinol-4-one 3-carboxylic acid 6,8-difluoro-7-(3-methylsulfonylphenyl)-1-ethyl1,4-dihydroquinol-4-one 3-carboxylic acid 6, 8-difluoro-7- (4-hydroxyphenyl)-1-methyl-l,4- dihydroquinol-4-one 3-carboxylic acid and 6,8-difluoro-7-(3-hydroxymethyl-4-hydroxy)-1ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid. Specific preferred compounds wherein R2 is hydrogen are 6-fluoro-7-phenyl-l-ethyl-1,4-dihydroquinoi-4-one 3-carboxylic acid 6-fluoro-7-(4-aminophenyl)-l-ethyl-1,4-dihydro- quinol-4-one 3-carboxylic acid 6-fluoro-7-(4-nitrophenyl)-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid 6-fluoro-7-(4-formamidophenyl)-l-ethyl-1,4-dihy- droquinol-4-one 3-carboxylic acid 6-fluoro-7-(4-acetamidophenyl)-l-ethyl-1,4-dihy- droquinol-4-one 3-carboxylic acid 6-fluoro-7-(4-(N-(N'N'-dimethylformamidino))phenyl)-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid 6-fluoro-7-(4-formylphenyl)-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid 6-fluoro-7-(4-hydroxymethylphenyl)-1-ethyl-1,4 dihydroquinol-4-one 3-carboxylic acid 6-fluoro-7-(3-hydroxymethylphenyl)-1-thyl-1,4- dihydroquinol-4-one 3-carboxylic acid 6-fluoro-7-(4-aminosulfonylphenyl)-1-ethyl-1,4dihydroquinol-4-one 3-carboxylic acid and 6-fluoro-7-(4-hydroxyphenyl)-1-(4-fluorophenyl1,4-dihydroquinol-4-one carboxylic acid. Other preferred compounds, of the, invention are those wherein R2 and Y when taken together have the formula -X-(CH2) (CH2)n-CHR4- wherein X is O, n is 1 and R4 is methyl, e.g. 9 fluoro-10-(4-aminosulfonylphenyl)-3-methyl-7-oXo-2,3- dihydro-(7E)-pyrido-(1,2,3-de)-1,4-benzoxazine-6- carboxylic acid. The present invention also relates to antibacterial compositions comprising an antibacterially acceptable carrier and a compound of formula I. Preferred compositions are those wherein the compound of formula I is a preferred compound as described above. The term "polyhaloalkyl" when used in the definition of R3 means an alkyl having more than one halogen. Examples of such polyhaloalkyl groups are dichioromethyl, aibromoethyl, perfluoropropyl. The term "halo" or "halogen" whenever used in the claims and the description, e.g. in the definition of R3, means fluoro, chloro, bromo or iodo. The compounds of formula I may be prepared by transition metal catalyst coupling of an appropriate arylmetallic compound containing group R3 as defined above with the appropriate 7-R-quinolinone ester of the formula II EMI6.1 wherein R2 and Y are as defined above, R' is alkyl of 1 to 6 carbon atoms and R5 is bromo or iodo. The coupling reaction is carried out in a reaction-inert solvent, i.e. a solvent which does not interfere with the coupling reaction of the arylmetallic compound with the compound of formula II. Suitable reaction inert solvents are ethers, e.g. dialkylethers such as diethylether and dipropylether, dimethoxyethane, and cyclic ethers such as tetrahydrofuran (THF). Cosolvents may be used with the ethers, if desired, e.g. to enhance the solubility therein of the reaction materials. Examples of suitable cosolvents are aliphatic and aromatic hydrocarbons of 5 to 10 carbon atoms such as benzene and toluene. Other suitable cosolvents are cosolvent complexing agents such as tetramethylethylenediamine (TMEDA) and hexamethylphosphonictriamide (HMPA) as known to those skilled in the art. The arylmetallic compounds containing group R3 may be prepared by known methods. For instance, they may be prepared from the corresponding halide of formula R3R5 nn which R3 and R5 are as defined above by direct lithium-halogen exchange using n-butyl, sec-butyl or t-butyl lithium followed by transmetallation by a wide variety of salts by known methods such as described by E. Negishi, Organometallics in Organic Synthesis, Vol. 1, page 104. The salts used in the transmetallation may be selected from the salts of zinc, cadmium, magnesium, mercury, tin, silver, copper, boron and aluminum, preferably zinc. The most commonly used salts are the halides, particularly chlorides, bromides, and odides, and cyanides such as copper cyanide. The most advantageous salt is zinc chloride. The above treatment with a butyl lithium compound is generally carried out at -78 to -50 C, in a suitable solvent such as ethçrfs alone or in admixture with an aliphatic or aromatic hydrocarbon solvent having from 5 to 10 carbon atoms. Suitable ethers are for instance dialkylethers such as diethylether, cyclic ethers such as THF, and dimethoxyethane. Suitable hydrocarbon solvents are for instance toluene and benzene. The treatment with the butyl lithium is best carried out in THF at -780C. The arylmetallic compounds may also be prepared by direct reaction of the corresponding arylhalide with a metal in the zerovalent state. These metals are alkali metals such as lithium, sodium and potassium, alkaline earth metals such as magnesium, and transition metals such as zinc. The reaction temperatures may range from -1000C for very active metals to 100 C. Again, solvents of use in this process are ethers alone or in admixture with hydrocarbons having from 5 to 10 carbon atoms such that at least one equivalent of the ether is present. Alternatively, the arylmetallic compounds may be formed by hydrogen-metal exchange between a corre sponding aryl compound and a strong base such as t-butoxide-butyl-lithium, TMEDA-butyllithium, or lithium or potassium hexamethyldisilizane. The arylmetallic compound is generally not isolated before reaction by coupling with compound (II). The coupling of the arylmetallic compound with the 7-haloquinolinone ester of formula II is in the presence of a transition metal catalyst usually in an amount of 0.5 - 10 mole %. The transition metal catalyst may be of the 0 or II oxidation state and contains a transition metal, that is a metal selected from Groups Ib through Vilib and VIII of the Periodic Table as set out in Lange's Handbook of Chemistry, 11th Edition. Suitable metals are for instance platinum, cobalt, iron, zirconium, molybdenum, ruthenium, manganese and rhodium, and preferred metals are palladium, platinum and nickel. The transition metal is combined with a ligand to form the catalyst. Suitable known ligands are phosphorus-containing ligands such as PPh3, P(CH3)3, P(C2H5) 3' P(o-tolyl)3, P(o-xylyl)3, Ph2P(CH2)n PPh2 wherein n is an integer from 1 to 4, and (C113)2 P(CH2)2 P(CH3)2; or cis Ph2CH=CHPh2, acetonylacetonate, 2,2'- bipyridyl pyridine and others as described in Tamao et al., Bull. Chem. Soc. Japan, 49(7), 1959 (1976). Other transition metal catalysts are disclosed in A. Sekiya et al., J. Organometal. Chem., 118, 349-354 (1976) and E. Negishi, Acc. Chem. Res., 15, 340-348 (1982) and references cited therein. Ph is phenyl. The preferred transition metal catalysts are 3 2 NiHal2, (PPh3)4 Ni, (PPh3) PdHal2, and (PPh3)4 Pd wherein Hal is chloro, bromo or iodo and Dh is phenyl. The most preferred catalyst is tetrakis(triphenylphosphine) palladium. For the preparation of compounds wherein R2 and Y are taken together, the preferred catalyst is (PPh3)2NiCl2. The reaction temperature of the coupling process generally ranges from room temperature to 50 CC. Methods for the preparation of the compounds of formula II are analogous to those described in the art. The overall reactions of two methods analgous to those in the prior art are set out in reaction Schemes A and B hereafter. In Scheme A, an aniline of formula IV wherein R2 and R5 are as defined above is reacted with a dialkyl alkoxymethylene malonate of formula V wherein R' is an alkyl group of 1 to 6 carbon atoms or benzyl. The reaction is generally carried out without solvent at about 100 to 2000C, preferably 150 to 1750C, for about 0.5 to 24 hours, usually for 0.5 to 2 hours. The resulting intermediates of formula VI are crystallized from a hydrocarbon or ethereal solvent such as light petroleum or diethyl ether and cyclized by heating at about 150 to 2500C in high boiling solvents such as dichlorobenzene, tetralin, diphenylether or diethyleneglycol dimethylether, preferably Dowtherm A which is a commercially available high boiling solvent mixture of diphenylether and dibenzofuran. The reaction time ranges from about 0.5 to 12 hours. The intermediates of formula VII formed above are N-substituted with a halide Y-Hal wherein Y is as defined above and Hal is halogen. Examples of suitable halides are ethyliodide, 2-fluoro-l-iodoethane, allylbromide and 2-bromoethanol. The adduct formed on reaction with 2-bromoethanol may be converted to a compound of formula I wherein Y is vinyl by hydroxyl activation with e.g. thionyl chloride followed by elimination with a suitable base such as triethylamine, diazabicycloundecene and diazabicyclononane. Generally, the substitution is carried out in DMF with an inorganic base such as potassium carbonate temperatures ranging from room temperature to 1100C. This reaction similarly proceeds when R5 in formula VII is replaced by R3 as defined before to produce the compounds of formula I provided that R' in compounds (VII) is R1 as defined above except R1 is hydrogen requiring an additional hydrolysis step. The mono- or did For anilines of formula IV, also used in the reaction of Scheme B hereafter, may be prepared by conventional nitration and reduction methods from the corresponding fluorobenzenes which are commerically available. Scheme A EMI11.1 In Scheme B, an aniline of formula X wherein R2 R5 and Y are as defined above is reacted with a dialkyl alkoxymethylene malonate of formula V wherein each 2' is alkyl having 1 to 6 carbon atoms or benzyl. The reaction conditions are as described above with reference to the conversion of compounds IV into V in Scheme A. The cyclization of compound XI fo-rmed above is by heating in an acidic medium such as polyphosphoric acid at about 100 to 2500C for about 0.5 to 24 hours, preferably at 100 to 1500C for 0.5 to 2 hours. This procedure is described by Albrecht, R., Prog. Drug Res., Vol. 21, 35-49 (1977). The resulting ester of formula II is usually purified by recrystallization or chromatography. The compounds of formula X may be prepared from those of formula IV by conventional methods. For instance, in Scheme B, an aniline of formula IV may be reacted with acetic anhydride in ethanol at about 25 to 100 C. The formed compound of formula VIII is reacted with a suitable base such as sodium hydride and N-substituted with an appropriate halide, tosylate or mesylate containing group Y. The acetyl group in the formed compound of formula IX is removed by refluxing in aqueous medium such as 6N hydrochloric acid to form the compound of formula X. Alternatively, N-substituted anilines of formula X may be formed by reductive amination with an appropriate aldehyde and a suitable reducing agent such as diborane, palladium on carbon with hydrogen, sodium borohydride or sodium cyanoborohydride Scheme B EMI13.1 or by acylation of said aniline of formula IV by reaction with the appropriate anhydride or acid chloride and direct reduction to anilines X with diborane in THF. The initial N-substitution of formula IV in Scheme B, rather than the later one of compounds of formula VII in Scheme A, is particularly useful when Y is polyfluoroalkyl since substitution with polyfluoroalkyl halides is not a viable route. The intermediates of formula II wherein R2 and Y are taken together to form tricyclic compounds are prepared by the methods of Schemes C to H hereafter. The initial compound used in these methods is 2,4-difluoro-3-bromo-l-nitrobenzene formed from 1,3difluoro-2-bromobenzene by conventional nitration. Scheme C shows the preparation of tricyclic intermediates of formula XVII having a five-membered third ring in which R4 is as defined above. SCHEME C EMI15.1 2-4-Difluoro-3-bromonitrobenzene is reacted with a reagent of the formula EMI16.1 wherein Z is sulfur, oxygen, NH or NCH3, in a polar organic solvent such as THF. When Z is sulfur, the reaction requires the presence of an organic base such as triethylamine. When Z is oxygen, a base such as sodium hydride is required for the reaction. Triethylamine, pyridine or another base is required when Z is NF or NCH3 when only one equivalent of the above reagent is used. The compound of formula XII is selectively reduced to the corresponding aniline by catalytic hydrogenation or by chemical reduction such as with stannous chloride in ethanol. After condensation of XIII with diethylethoxymethylene malonate at about 1500C, the compound of formula XIV is formed. Ring cyclization of XIV is by heating with e.g. Dowtherm A as the solvent. The substituted benzyl group is removed under acidic conditions e.g. with trifluoromethanesulfonic acid, trifluoroacetic acid and anisole. The third ring is formed by reaction of XVI with R4CHI2 or R4CHO wherein R4 is as defined above to provide the compound of formula XVII. Scheme D shows the preparation of tricyclic intermediates of formula XXIII wherein n is 0, 1 or 2, Z is S, NH or NCH3, and R4 is as defined above. SCHEME D EMI17.1 2,4-Difluoro-3-bromonitrobenzene is reacted with a compound of the formula HZ-(CH2)n-CHR4-OH wherein Z is S, NA or NCH3 a n is 0, 1 or 2, in a polar solvent such as THF at OOC to room temperature. When 2 is S, a base is needed such as triethylamine. The compound of formula XVIII is reacted with a compound providing a protecting group such as a silyl group, specifically tbutyldimethylsilyi chloride, usually in DMF and imidazole, to form the compound of formula XIX. The next sequence of steps is the same as described with reference to Scheme B. Thus, there is hydrogenation of the nitro group and condensation with diethylethoxymethylene malonate. The compound of formula XXI is treated with fluoride to remove the protecting silyl group and cyclization is attained, after first reacting XXII with triphenylphosphine and ethylazodicarboxylate to close the second ring, by heating with polyphosphoric acid or ester at about 120 to 1500C for 0.5 to 2 hours. "Silyl" is a trialkyl silyl group of the formula EMI18.1 wherein R" is independently an alkyl group of 1-4 carbon atoms. In Scheme E is illustrated the preparation oz tricyclic intermediates of formula XXIX wherein n and R4 are as defined above. 2,4-Difluoro-3-bromo-nitrobenzene is reacted with a monoprotected diol of formula Silyl-O-(CH2)n-CHR6-OH and a base like sodium hydride in THF at 0 C to room temperature to give a compound SCHEME E EMI19.1 of formula XXIV. In a sequence identical to that of Scheme D, intermediate XXIV is converted to XXIX by reduction of the nitro group, condensation with ethoxymethylene malonate to give XXIV, deprotection with fluoride, cyclization of the second ring with triphenyl phosphine and ethyl azodicarboxylate and cyclization to the tricyclic compound with polyphosphate acid or ester at 1200C to 1500C for 0.5 to 2 hours. Scheme F illustrates other methods for synthesis of tricycles of formula XXIX. Difluoro-3-bromonitrobenzene is reacted either directly with a hydroxyketone HO(CH2)nC(O)R4 wherein R4 and n are as defined above or first with potassium hydroxide in DMSO to give phenol XXX and then with a haloketone X(CH2)nC(O)R4 with R4 and n as defined above and X halogen to give common intermediate XXXI. The compound XXXI undergoes reductive cyclization to benzoxazine XXXII. The compound XXXI I is then condensed with ethoxymethylene malonate and cyclized in polyphosphate acid or ester using conditions described above to provide tricycle XXIX. Schemes G and H illustrate the synthesis of tricyclic intermediates wherein Z is CH2, and R4 and n are as defined above. SCHEME F EMI21.1 SCHEME F (Cont'd) EMI22.1 SCHEME G EMI23.1 Scheme G illustrates the synthesis of tricyclic intermediates of formula XLI having a five-membered third ring. 2,4-Difluoro-3-bromonitrobenzene is reacted with diethylsodio-malonate in THF at 00C to room temperature to give intermediate XXXIII. Monodecarboxylation is effected with para-toluene sulfonic acid in ThF and water at 800C. The resulting ester XXXIV is reduced with diborane in THF at 500C for 48 hours. Protection of the alcohol with a "silyl" protecting group and reduction of the nitro group with Raney-Nickel in ethanol gives intermediate aniline XXXVII. Through the identical sequence of steps described in Schemes D, E and F, the tricyclic compound XLI is formed. In Scheme H is illustrated the preparation of tricyclic intermediates of formula XLIX having six and seven-membered third rings wherein R4 is as defined above and n is 1 or 2. Using intermediate XXXVII from Scheme G, the Silyl group is removed and the hydroxyl group in resulting compound XXXVII is activated by reaction with para-toluene sulfonyl chloride in CH2 Cl2 and pyridine. Addition of either one or two carbon atoms is accomplished by reaction of XLII (wherein Ts is p-toluenesulfonyl) with KCN, the anion of dithioacetal EMI24.1 or the anion of R4-functionalized diethyl malonate EMI24.2 wherein R4 is as defined above. The resulting Scheme H EMI25.1 intermediates of carbanion addition are subjected to hydrolysis, decarboxylation if necessary, and reduction by standard methods to give intermediate XLIII wherein n is 1 or 2. "Silyln protection, reduction of the nitro group to give aniline XLV and diethyl ethoxymethylene malonate condensation gives XLVI. The protecting group is removed by treatment with fluoride ion and thesecond and third rings are formed by triphenyl phosphine, ethyl azodicarboxylate and polyphosphoric acid or ester, respectively, to give intermediate XLIX wherein n is 1 or 2 Compounds of formula I wherein R3 is phenyl substituted by alkylsulfinyl or alkylsulfonyl may be obtained by conventional oxidation of the corresponding compounds wherein R3 is phenylmercaptoalkyl. The compounds (I) wherein R3 is hydroxyphenyl may be formed by reacting the corresponding compound wherein R3 is methoxyphenyl with an ether-cleaving reagent such as borontribromide or trimethylsilyliodide. Compounds (I) wherein R3 is hydroxymethylphenyl are conveniently prepared by reacting the corresponding compound wherein R3 is trialkylsilyloxymethylphenyl wherein each alkyl has 1 to 4 carbon atoms with an ether-cleaving agent as described above. Compounds (I) wherein R3 is nitrophenyl may be prepared by conventional nitration of compounds (I) wherein R3 is phenyl. Reduction of such nitrophenyl compounds provides compounds wherein R3 is aminophenyl. These aminophenyl compounds on alkylation with usual alkylating agents such as alkyl halides result in compounds (I) wherein R3 is alkylaminophenyl or dialkylaminophenyl. Simi- larly, compounds (I) wherein R3 is alkylaminoalkyl phenyl and dialkylaminoalkylphenyl are prepared by alkylation of corresponding compounds wherein R3 is aminoalkylphenyl. Compounds (I) wherein R3 is N,N-dimethylformamidophenyl may be formed by reacting compounds wherein R3 is aminophenyl with formic acid cr a formic acid derivative such as ethylformate. Compounds (I) wherein R3 is alkanoylamino may be formed by reactirrg corresponding compounds wherein R3 is aminophenyl with an alkanoyl group containing reagent such as an acid chloride or anhydride, e.g. acetic anhydride. Compounds (I) wherein R3 is formamidinophenyl may be formed by reacting compounds (I) wherein R3 is amino-phenyl with dimethylformamide dimethylacetel in toluene. Aminosulfonyl-substituted phenyl compounds may be obtained by reacting compounds (I) wherein R3 is chlorosulfonylphenyl with an amino group introducing reagent such as ammonia or an amine. The chloro sulfonyl group is introduced by reacting compounds wherein R3 is phenyl with chlorosulfonic acid. Alkylation of the aminosulfonylphenyl compounds will result in compounds (I) wherein R3 is alkylaminosulfonylphenyl or dialkylaminosulfonylphenyl. These latter compounds alternatively may be obtained by reacting compounds (I) wherein R3 is chlorosulfonylphenyl with a monoalkyl amine or a dialkyl amine, respectively. Compounds (I) wherein R3 is formylphenyl may be prepared by oxidation of the corresponding compound wherein R3 is hydroxymethylphenyl, e.g. by oxidation with oxalyl chloride in DMSO and triethylamine. Compounds (I) wherein R3 is ureidophenyl may be formed by reacting compounds wherein R3 is aminophenyl with alkali metal cyanate such as sodium cyanate. Compounds (I) wherein R3 is azidomethylphenyl may be prepared by reacting compounds wherein R3 is methane-sulfonyloxymethylphenyl with an azide such as sodium azide. Compounds (I) wherein R1 is hydrogen may be obtained by acid or base hydrolysis of the corresponding esters wherein R1 is alkyl or benzyl, or by hydrogenolysis of corresponding compounds wherein R1 is benzyl. The compounds of formula I have antibacterial properties particularly when in the acid, cation salt or acid addition salt form. The pharmaceutically acceptable cation salts of the compounds of formula I may be prepared by conventional methods. For instance, the salts may be prepared by treating the compound of formula I in which R1 is hydrogen with an aqueous solution of the desired phar-maceutically acceptable cation and evaporating the resulting solution to dryness, preferably under reduced pressure. Suitable pharmaceutically acceptable cation salts for this purpose include alkali metal salts such as potassium, sodium and lithium salts, alkaline earth metal salts such as calcium and magnesium salts, and the ammonium or organic amine salts, such as choline or diethanolamine salts. The compounds of the invention can be administered alone, but will generally be administered in admixture with a pharmaceutical carrier selected with regard to the intended route of administration and standard pharmaceutical practice. For example, they can be administered orally in the form of tablets containing such excipients as starch or lactose, or in capsules either alone or in admixture with excipients, or in the form of elixirs or suspensions containing flavoring or coloring agents. In the case of animals, they are advantageously contained in an animal feed or drinking water in a concentration of 10-1000 ppm, preferably 10300 ppm. They can be injected parenterally, for example, intramuscularly, intravenously or subcutaneously. For parenteral administration, they are best used in the form of a sterile aqueous solution whtch'anontain other solutes; ior-example, enough salt or glucose to make the solution isotonic. Generally, compound (I) is dissolved in a pharmacutically acceptable liquid such as water which may contain buffers, preservatives, materials to make the solution isotonic, e.g. isotonic saline, or other materials known to those skilled in art. The reconstituted solution so prepared may be used for direct parenteral injection or may be added to a solution such as an I.V. solution for slow administration by infusion. The invention also provides pharmaceutical compositions comprising an antibacterially effective amount of a compound of the formula (I) together with a pharmaceutically acceptable diluent or carrier. The compounds of the invention can be administered to humans for the treatment of bacterial diseases by either the oral or parenteral routes, and may be administered orally at dosage levels of about 0.1 to 500 mg/kg/day, advantageously 0.5-200 mg/kg/day, and parenterally at dosage levels of about 50 to 500 mg/kg/day given in a single dose or up to 3 divided doses. Variations will necessarily occur depending on the weight and condition of the subject being treated and the particular route of administration chosen as will be known to those skilled in the art. The antibacterial activity of the compounds of the invention is shown by testing according to the Steer's replicator technique which is a standard in vitro bacterial testing method described by E. Steers et al., Antibiotics and Chemotherapy, 9, 307(1959). EXAMPLE 1 3-Bromo-2,4-difluoronitrobenzene A. A mixture of 10 ml concentrated HNO3 and 10 ml concentrated R2S04 was added dropwise with cooling to a stirred solution of 30 g 2,6-difluorobromobenzene in 50 ml of concentrated sulfuric acid. The rate of addition was controlled such that the temperature of the mixture did not rise above 550C. After the addition was complete the reaction mixture was allowed to stir at room temperature for 2 hours. It was then poured onto ice and the resulting solid was collected by filtration, then poured onto ice and the resulting solid was collected by filtration, washed with water and dried, yielding a pale yellow solid, m.p. 50 - 5l.50C, 84% yield (31.2 g). Anal.: Calcd. for C6H2BrF2N02: C, 30.28; 8, 0.85; Br, 33.57; F. 15.96; N, 5.898, Found: C, 30.34; H, 0.98; Br, 33.81; F, 16.04; N, 5.81%. 3-Amino-2,6-difluorobromobenzene B. A mixture of 31. 2 g of 3-bromo-2, 4-difluoronitrobenzene, 150 ml concentrated HCl and 150 g stannous chloride dihydrate was placed in a preheated oil bath at 600C. A small quantity of diethyl ether was then added to bring about solution. After heating at 600C for 30 minutes, the mixture was cooled and then poured into 1500 ml ice/water. The solution was then basified to pH 13 using 30% aqueous sodium hydroxide while maintaining the temperature below 25"C by external cooling. The mixture was extracted three times with chloroform and the combined organic extracts were washed with water. The organic phase was dried and evaporated to yield a white solid, m.p. 77 - 780C, yield 90.5% (24.7 g). Ethyl 7-bromo-6,8-difluoro-4-hydroxyquinoline-3-carboxylate C. A stirred mixture of 26 g of 3-amino-2,6-difluoro- bromobenzene and 27 g of diethyl ethoxymethylenemalonate was heated at lSO0C for 1 hour. After cooling1 100 ml of Dowtherm "A" (commercially available high boiling inert solvent mixture of diphenylether and dibenzofuran) was added and the mixture was heated under nitrogen at 260 C for 1.5 hour. the mixture was cooled to room temperature and 200 ml of hexanes was added. the resulting precipitate was collected by filtration, washed with hexanes and dried to give a cream solid, m.p. 2850C, yield 78% (32.32 g). Ethyl 7-bromo-6,8-difluoro-1-ethyl-1,4 dihydroquinol-4-one 3-carboxylate D. A mixture of 32 g of ethyl 7-bromo-6,8-difluoro-4- hydroxyquinoline-3-carboxylate, 45.1 g iodoethane and 50 g of anhydrous potassium carbonate in 450 ml N,Ndimethylformamide was heated at 900C with stirring for 2 hours. The mixture was then cooled, poured into water and the resulting precipitate was collected by filtration and dried. This crude product was purified by eluting on a silica column with ethyl acetate/hexanes (60:40) which on isolation yielded white ctystals, m.p. 153-155 C, yield 86% (29.84 g). Analysis: Calcd. for C14E12BrF2N03: C, 46.66 H, 3.33; N, 3.88%. Found: C, 46.38; H, 3.37; N, 3.87%. Ethyl 6,8-difluoro-l-ethyl-7-phenyl-1,4- dihydroquinol-4-one 3-carboxylate (21=ethyl, R2=F, R3-phenyl, Y=ethyl) E. A 2.7 M solution (1 ml) of phenyllithium in 60/30 cyclohexane/diethyl ether was diluted with 10 ml dry tetrahydrofuran. This.mixture was stirred under nitrogen at room tempeature and a solution' of 409 mg anhydrous zinc chloride in 10 ml tetrahydrofuran was added. After 20 minutes, a solution of 360 mg of ethyl 7-bromo-6,8-difluoro- l-ethyl-1,4-dihydroquinol-4-one 3-carboxylate in 10 ml tetrahydrofuran and 124 mg of palladium tetrakis (triphenyl phosphine) were added. The resulting mixture was heated at 40 - 450C for 18 hours. The mixture was then cooled and poured into 200 ml water. The mixture was stirred for 20 minutes and then extracted three times with chloroform. The organic extracts were combined, washed with water, dried and evaporated to give the crude product. This material was purified by eluting on a silica column with ethyl acetate which on isolation yielded the pure product as a solid (251 mg, 70% yield). RtR (CDC13, 60MHz): 8.4 (s, 1H), 8.1 (dd, 1E, J = 9Hz and 2Hz), 7.5 (s, 5H), 4.4 (m, 4H), 1.5 (t, 3H, J 5 6.5Hz), 1.4 (t, 3H, 6.5Hz). MS: Calcd. for c2sH17F2N03: 357.1178; Found: 357.1164. 6,8-Difluoro-l-ethyl-7-phenyl-1,4 dihydroquinol-4-one 3-carboxylic acid (R1=H; R2=F; R3=phenyl; Y=ethyl). F. Ethyl 6,8-difluoro-1-ethyl-7-phenyl-1,4-dihydroquinol-4-one 3-carboxylate (186 mg) was dissolved in 10 ml 1:4 hydrochloric acid/acetic acid and the mixture was heated at reflux for 3.5 hours. The mixture was cooled and the resulting precipitate collected by filtration, washed with water and dried1 yielding solid product, mwp. > 260 C (114 mg, 66% yield). NMR(DMSO-d6, 250MHz): 8.75 (s, 1H), 7.9 (dd, 1H, J = 9Hz and 2Hz), 7.35 (s, 5H), 4.5 (m, 2H), 1.35 t', 3H, J = 6.5Hz). MS: Calcd. for C18H13F2No3: 329.0864. Found: 329.0860. Anal.: Calcd. for Cl8H13F2N=3.2/3H2O; C, 63.34; H, 4.00; , 4.10%. Founds C,- 63.08; fl',- 4.02; N, 4.14%. EXAMPLE 2 Ethyl 6,8-difluoro-1-ethyl-7-(4-methylthiophenyl) 1,4-dihydroquinol-4-one 3-carboxylate (R1=ethyl; R2=F; R3=4-methylthiophenyl; Y=ethyl) 12.5 MÚ of a 2M solution of t-butyllithium in pentane was added dropwise to a stirred solution of 2.53 g 4-bromothioanisole in 35 ml of dry tetrahydrofuran at 780C under nitrogen. After stirring for 1 hour at -780C, a solution of 1.7 g anhydrous zinc chloride in 25 ml of tetrahydrofuran was added and the mixture was stirred for a further 15 minutes at -78 C. To the resulting solution, 620 mg of palladium tetrakis(triphenylphosphine) was added, followed by the slow addition of a solution of 1.8 g of ethyl 7-bromo-6,8-difluoro-1-ethyl-1,4-dihydro- quinol-4-one 3-carboxylate in 10 ml tetrahydrofuran. After the addition was completes the mixture was stirred for a further 15 minutes at -780C and then allowed to warm slowly to room temperature. After a further 24 hours, 5 ml of 5% aqueous ammonium chloride was added followed by 5 ml of 1 M hydrochloric acid. The mixture was stirred for 10 minutes and it was then poured into 200 ml water and extracted with three 50 ml portions of chloroform. The combined organic extracts were washed once with water, dried and evaporated to yield the crude product as a yellow solid. This was purified by eluting on a silica column with ethyl acetate which on isolation gave the required product (1.7 g, yield 55%). NMR (CDCl3, 60MHz); 8.35 (s, 1H), 8.05 (dd, lH, J = 9z and 2Hz), 7.35 (m, 4H), 4.35 (2q, 4H, J = 6.5Hz), 2.6 (s, 3H), 1.5 (t, 3H, J 6.5Hz), 1.4 (t, 3H, J =6.5 Hz), MS: Calcd. for C21H15FNO3S: 403.1054; Found: 403.1031. EXAMPLE 3 Ethyl 6,8-difluoro-1-ethyl-7-(4-methyl sulfinylphenyl ) -1, 4-dihydroquinol-4-one 3-carboxylate (R1=ethyl; R2=F, R3=4-methyl- sulfinylphenyl; Y=ethyl) A. A solution of 101 mg 85% m-chloroperbenzoic acid in 3 ml dichloromethane was added dropwise to a stirred solution of 201 mg of ethyl 6,8-difluoro-l-ethyl-7-(4-methyltfiio- phenyl)-1,4-dihydroquinol-4-one 3-carboxylate in dichloromethane at room temperature. After 1.5 hour, the reaction mixture was washed twice with 10 ml 5% aqueous sodium bicarbonate and the organic phase was dried and evaporated to give the crude required product as an oil. This was purified by elution on silica gel, first with ethyl acetate and then using a gradient elution with ethyl acetate/ methanol. The product was a hard glass (90 mg, yield 43%). NMR (CDCl3, 60MHz): 8.4 (s, 1H), 8.1 (dd, 1H, J = 9 Hz and 2Hz), 7.7 (m, 4H), 4.4 (2q, 4H, J = 6.5Hz), 2.8 (s, 3H), 1.5 (t, 3H, J =6.5Hz), 1.4 (t, 3E, J 6.5Hz). 6,8-Difluoro-1-ethyl-7-(4-methylsulfinylphenyl) 1, 4-dihydroquinol-4-one 3-carboxylic acid (R1=H; R2=F; R3=4-methylsulfinylphenyl; Y=ethyl) 3. 60 Mg (72% yield) was prepared from 90 mg ethyl 6,8 difluoro-l-ethyl-7-(4-metlylsulfinylphenyl)-1,4-dihydro- quinol-4-onp 3-carboxylate by the method of Example 1F. White solid was obtained, m.p. 2600C. NMR (DMSO d6, 250MHz); 9.07 (s, 1H),8.1 (dd, 1H, J=9Hz and 2Hz), 7.87 (m, 4H), 4.65 (m,2H), 2.85 (s, 3H), 1.5 (t, 3H, J=6Hz). MS: Calcd. for C19H15F2NO4S: 391.0690. Found: 391.0621. Anal.: Calcd. for C19H15F2NO4S: C, 58.31; H, 3.83; N, 3.58%. Found: C, 57.89; H, 4.15; N, 3.36%. EXAMPLE 4 4-Fluoro-3-phenylnitrobenzene A. 2-Fluoro-5-nitroaniline (30 g) was added portionwise over 45 minutes to a refluxing solution of 60 ml isoamyl nitrite in 225 ml benzene. After heating for a further 30 minutes at reflux, the mixture was cooled and the solvent removed by evaporation in vacuo. The residue was triturated many times with hot petroleum ether and the combined extracts were evaporated to give the product as a red oil (19.9 g, yield 49%). This material was used without further purification. NMR (CDC13, 60MHz): 8.0 8.4 (m, 3H), 7.1 - 7.6 (m, 5H). 4-Fluoro-3-phenylaniline B. A mixture of 18.5 g of 4-fluoro-3-phenylnitrobenzene, 76.7 g of stannous chloride dihydrate and 150 ml concentrated hydrochloric acid was 'heated at 60 C for 2 hours with stirring. After cooling, the resulting precipitate was dissolved in water and the mixture was basified with sodium carbonate. The mixture was extracted five times with chloroform and the combined organic extracts were dried and evaporated to yield the product as a pale brown oil (10.9 g, yield 68%) which was used without further purification. NMR (CDC13, 60MHZ): 7.15 (m, 5H), 7.1 - 6.1 (m, 3R), 3.3 (br,s, 2H). Diethyl 4-fluoro-3-phenylanilinomethylenemalonate C. A mixture of 10.9 g of 4-fluoro-3-phenylaniline and 12.54 g diethyl ethoxymethylenemalonate was heated at 1500C for 15 minutes. The mixture was then cooled and triturated with petroleum ether to give the solid product (16.73 g, 80% yield) which was used without further purification. NMR (CDCl3, 60MHz): 8.3 (d, 1H, J=14Hz), 7.5 - 6.9 (m, 8H) 4.2 (m, 4H), 1.4 (m, 6E). Ethyl 6-fluoro-7-phenylquinolin-4-ol 3-carboxylate D. A solution of 16.73 g of diethyl 4-Eluoro-3-phenyl- anilinomethylenemalonate in 100 ml Dowtherm "A" was heated at 250 C with stirring for 2.5 hours. The mixture was cooled and the resulting precipitate was collected by filtration, washed with petroleum ether and dried, m.p. > 270 Co (12.37 g, 85%.yield). NMR (trifluoroacetic acid-d, 60 MHz); 9.3 (s, lH), 8.2 (m, 2H), 7.5 (m, 5H), 4.7 (q, 2E, J = 6.5Hz), 1.5 (t, 3H, J = 6.5Hz). Ethyl 1-ethyl-6-fluoro-7-phenyl-1,4-dihydro quinol-4-one 3-carboxylate (R1=ethyl; R2=H; R3=phenyl; Y=ethyl) E. A mixture of 12.4 g ethyl 6-fluoro-7-phenylquinolin- 4-ol 3-carboxylate, 11 g anhydrous potassium carbonate and 18.7 g iodoethane in 100 ml N;N-dimethyl formamide was heated at 800C for 4 hours. The reaction mixture was cooled, poured into ethyl acetate and the mixture was extracted several times with water. The organic phase was dried and evaporated to give a solid product which was washed well with diethyl ether and dried. White solid was obtained, m.p. 180 - 1820C (9.16 g, 68% yield). NMR (CDC13, 60MHz); 8.4 (s, 1H), 8.05 (d, 1R, J = 10Hz), 7.5 (m, 6H), 4.3 (q, 2H, J=6.5 Hz), 4.25 (q, 2H, J=6.5Hz(, 1.55 (t, 3H, 3 = 6.5Hz), 1.35 (t, 3H, J = 6.5Hz). 1-Ethyl-6-fluoro-7-phenyl-1,4-dihydroquinol-4-one 3-carboxylic acid (R1=R2=H; R3=phenyl;Y=ethyl). F. A mixture of 0.44 g ethyl 1-ethyl-6-fluoro-7-phenyl- 1,4-dihydroquinol-4-one 3-carboxylate and 10 ml 1H sodium hydroxide was stirred at 900C for 1 hour. The mixture was cooled and poured into 20 ml water. The pH was adjusted to 7 with 1 M hydrochloric acid and the resulting precipitate was collected by filtration, washed with water1 then ether, and dried, yielding a white solid, m.p. 253 - 2560C (0.26 g, 65% yield). NMR (Trifluoroacetic acid-d, 60MHz): 9.4 (s, 1H), 8.3 (m, 2H), 7.6 (m, 5H), 4.9 (q, 2H, J s 6.5 Hz), 1.8 (t, 3E, J = 6.5Hz). Anal.: Calcd for C18H14FNO3.1.5 H2O; C, 63.90: H, 5.02; N, 4.148. Found: C, 63.52; H, 4.66; N 3.92%. EXAMPLE 5 Ethyl l-ethyl-6-Eluoro-7-(4-nitrophonyl)-1,4-dihydroquinol- -4-one 3-carboxylate (R1=ethyl; R2=H; R3-4-nltrophenyl; Y=ethyl) A. Ethyl 1-ethyl-6-fluoro-7-phenyl-1, 4-dihydroquinol 4-one 3-carboxylate (4 g) was added portionwise to zb stirred mixture of 12 ml concentrated sulphuric acid and 12 mi concentrated nitric acid at 0 C, After 1 hour at O.C, the mixture was poured onto ice and the resulting precipitate was collected by filtration. This solid was washed with ethyl acetate and then recrystallized from hot ethyl acetate to give a solid, m.p. 210 - 2120C (2.88 g, 68% yield). NMR (Trifluoroacetic acid d, 250MHz): 9.5 (s, 1H), 8.5 (m, 4H), 8.0 (m, 2H), 5.05 (q, 2H, J=6.5Hz), 4.75 (q, 2H, J=6.5Hz), 1.85 (t, 3H, J=6.5Hz), 1.5 (t, 3H, J = 6.5Hz). MS: 384 (parent), 312 (base peak). 1-Ethyl-6-fluoro-7-(4-nitrophenyl)-1,4-dihydro quinol-4-one 3-carboxylic acid (R1=H; 82' R3 and Y as in Example 5A) B. A mixture of 0.65 g of ethyl l-ethyl-6-fluoro-7- (4-nitrophenyl)-1,4-dihydroquinol-4-one 3-carboxylate and 15 ml 1 M sodium hydroxide was heated at 900C with stirring for 30 minutes -The mixture was cooled and then poured into 40 ml water. The pH of the mixture was adjusted to 7 with 1 M hydrochloric acid and the resulting precipitate was collected by filtration. The solid was washed with water, ether and ethyl acetate and then it was recrystallized from hot N,N-dimethylformamide to give a white solid, m.p. ) 2700C (0.29 g, 48% yield). NMR (Trifluoroacetic acid-d, 60MHz): 9.5 (s, 1H), 8.5 - 7.7 (m, 6E), 5.1 (q, 2H), 1.85 (t, 3H). EXAMPLE 6 Ethyl 1-ethyl-6-fluoro-7-(4-aminophenyl)-1,4 dihydroquinol-4-one 3-carboxylate (R1=Y=ethyl; R2=H; R3=4-aminophenyl A. A mixture of 1.7 g of ethyl 1-ethyl-6-fluoro-7-(4- nitrophenyl)-1,4-dihydroquinol-4-one 3-carboxylate, 12.75 g stannous chloride dihydrate and 13 ml concentrated hydrochloric acid were stirred at 0 C for 15 minutes and then at room temperature for 2 hours. The mixture was cooled and the resulting precipitate was collected by filtration, dissolved in water and the solution was adjusted to pH 9 with solid sodium bicarbonate. It was then extracted several times with ethyl acetate and then chloroform. The combined organic extracts were washed with water, dried and evaporated to give a white solid, m.p. 248 - 2500C (1.25 g, 78% yield). NMR (DMSO-d6, 250MHz); 8.7 (s, 1H), 7.9 (d, 1H, J w 11.5Hz), 7.75 (d, lR, J = 6Hz), 7.4 tdd, 2H, J = 92), 6.7 (d, 2H, J = 9Hz), 4.5 (q, 2H, J = 6.5Hz), 4.25 (q, 2H, J = 6.5Hz), 1.45 (t, 3H, J = 6.5Hz), 1.3 (t, 3H, J=6.5Hz). 1-Ethyl-6-fluoro-7-(4-aminophenyl)-1,4-dihydro quinol-4-one 3-carboxylic acid (R1=R4=H; R3=4-aminophenyl; Y=ethyl) B. A mixture of 0.8 g ethyl 1-ethyl-6-fluoro-7-(4- aminophenyl)-1,4-dihydroquinol-4-one 3-carboxylate and 16 ml 2 M hydrochloric acid were heated at reflux for 6 hours. The mixture was cooled and the resulting precipitate was washed with water and dried to give the product as a yellow solid, m.p. 270 - 272 C )0.59 g, 18% yield). NMR (Trifluoroacetic acid-d, 250MHz): 9.55 (s, 1H), 8.6 (d, 1H, J=8.5 Hz), 8.45 (d, 1H, J=6Hz), 8.0 (d, 2H, J t 9.5Hz), 7.85 (d, 2H, .3 r 9.5Hz), 5.1 (m, 2H), 1.9 (t, 3g). MS: 326 (parent), 282 (base peak). Anal.: Calcd. for C18H15FN2O2.2.5H2O: C, 58.22; H, 5.39; t4, 7.54%. Found: C, 58.25; H, 4.73; N, 7.44%. EXAMPLE 7 1-Ethyl-6-fluoro-7-(4-formamidophenyl)-1,4-dihydro quinol-4-one 3-carboxylic acid (R1=R2=H; R3=4-formamidophenyl; Y=ethyl). 1-Ethyl-6-fluoro-7-(4-aminophenyl)-1,4-dihydroquinol 4-one 3-carboxylic acid (100 mg) in 1 ml formic acid was heated at reflux for S hours. The mixture was cooled and the solvent removed by evaporation in vacuo. The residual solid was washed with water and diethyl ether and dried, yielding the product as a pale yellow solid, m.p. > 270 C. (86 mg, 79% yield). NMR (DMSO-d6/Trifluoroacetic acidd, 250MHz): 9.4 (s, 1H), 8.5 (s, 0.5H), 8.4 (d, 1H, J= 9Hz), 8.3 (d, 1H, J=6Hz), 8.2 (s, 0.5Hz), 7.9 (d, 2H, J= 8Hz), 7.8 (d, 2H, J = 8Hz), 5.0 (q, 2H, J = 6.5Hz), 1.75 (t, 3H, J=6.5Hz). Anal.: Calcd for C19H15FN2O4.1.5H2O: C, 59.84; H, 4.72, N, 7.358. Found: C, 60.24; H, 4.31; N, 7.08%. EXAMPLE 8 1-Ethyl-6-Fluoro-7-(4-acetamidophenyl)-1,4-dihydroquinol 4-one 3-carboxylic acid (R1=R2=R; R3=4 acetamidophenyl; Y=ethyl) 1-Ethyl-6-flluoro-7-(4-aminophenyl)-1,4-dihydroquinol 4-one 3-carboxylic acid (50 mg) was placed in a mixture of 1 ml acetic acid and 0.5 ml acetic anhydride and the mixture was stirred at room temperature for 1.5 hours. The resulting precipitate was collected by filtration washed with water and ether and dried, yielding the product as a white solid of 250 C (35 mg, 62% yield). NMR (Trifluoroacetic acidd, 250MHz): 9.5 (s, 1H), 8.55 (d, lH, J=9Hz), 8.4 (d, 1H, J = 6Hz), 7.85 (d, 2H, J= 6Hz), 7.75 (d, 2H, J = 6Hz), 5.05 Im, 2H), 2.55 (s, 3H), 1.85 (t, 3H, J = 6Hz). EXAMPLE 9 l-E hyl-6-fluoro-7-(N-(N',N'-d1methylformamidinsphenyl)- 1,4-dihydroquinol-4-one 3-carboxylic acid (R1=R2=H; R3=N-(N', N'-dimethylformamidinophenyl); Y=ethyl) A mixture of 1-ethyl-6-fluoro-7-(4-aminophenyl)-1,4- dihydroquinol-4-one 3-carboxylic acid (100 mg) and N,N- dimethylformamide dimethylacetal (74 mg) in toluene was heated at reflux for 3 hours. A further 38 mg of N, Ndimethylformamide dimethylacetal was then added and the mixture was heated at reflux for a further 2 hours. The mixture was cooled, the solvent removed by evaporation in vacuo and the residual solid was washed with ether and dried, yielding the product as a pale yellow solid of m.p. 215 2180C (70 mg, 57% yield). NMR (DMSO-d6/Trifluoroacetic acid d, 250MHz): 9.2 (s, 1R), 8.5(s, 1H), 8.3 (d, 1H, J = 9Hz), 8.15 (d, 1H, J= 6Hz), 7.85 (d, 2H, J 5 6Hz), 7.6 (d, 2H, J = 6Hz). 4.8 (m, 2H), 3.45 (d, 6H, J=18Hz), 1.65(t, 3H, J = 6Hz). MS: 381 (668). Anal.: Calcd. for C21H20FN303:C, 63.16; H, 5.51; N, 10.52%. Found: C, 62.94; H, 5.25; N, 9.94%. EXAMPLE 10 Ethyl 1-ethyl-6-fluoro-7-(4-chlorosulfonylphenyl)-1,4 dihydroquinol-4-one 3-carboxylate A. Chlorosulfonic acid (10 ml) was slowly added over 15 minutes to a stirred solution of ethyl 1-ethyl-5- fluoro-7-phenyl-1,4-dihydroquinol-4-one 3-carboxylate (2.5 g) in dichloromethane (20 ml) at 0 C. The mixture was stirred for a further 15 minutes at 0 C and then at room temperature for 1.5 hour. The mixture was poured into ice/water and the mixture was extracted twice with ethyl acetate. The combined organic extracts were dried and evaporated to give the product as an oily solid (1.4 g, 42% yield) which was used immediately without further purification. NMR (CDCl3, 60MHz): 8.6 (s, 1H), 8.4 - 7.4 (m, 6H), 4.4 (2q, 4H, J = 6.5Hz), 1.6 (t, 3H, 9 = 6.5Hz), 1.4 (t, 3H, J - 6.5Hz). Ethyl 1-ethyl-6-fluoro-7-(4-aminosulfonylphenyl)-1,4 dihydroquinol-4-one 3-carboxylate (R1=ethyl; R2=H; R3=4-aminosulfonylphenyl; Y=ethyl) B. A saturated ethanolic ammonia solution (1 ml) was added to a stirred solution of ethyl 1-ethyl-6-fluoro-7 (4-chlorosulfonylphenyl)-1,4-dihydroquinol-4-one 3carboxylate (0.7 g) in 8 ml dichloromethane at -5O-C. The mixture was allowed to warm slowly to room temperature. After 2 hours, the mixture was poured into water and the resulting precipitate was collected by filtration, washed with water, ethyl acetate and ether and dried, yielding the product as a white solid (0.4 g, 60% yield). NMR (DMSO-d6, 60MHz): 8.7 (s, 1H), 8.2 - 7.4 (m, 6E), 4.5 {q, 2H, J = 6.5Hz), 4.3 (q, 2H, J = 6.5Hz), 1.5 (t, 3H, J t 6.5Hz), 1.4 (t, 3H, J = 6.5Hz). 1-Ethyl-6-fluoro-7-(4-aminosulfonylphenyl)-1,4 dihydroquinol-4-one 3-carboxylic acid (R1=H; R2, R3 and Y as in Example 10 B) C. A mixture of 0.4 g ethyl l-ethyl-6-fluoro-7-(4 aminosulfonylphenyl ) -1, 4-dihydroquinol-4-one 3-carboxylate, 5 ml ethanol and 5 ml 1 M sodium hydroxyde was heated at 90 C for 30 minutes. The mixture was cooled, then concentrated in vacuo and the pE was adjusted to 7 with 1 M hydrochloric acid. The resulting precipitate was collected by filtration, washed and dried to give the product as a white solid, m.p. > 270 C (0.3 g, 78% yield). NMR (DMSO- d6/Trifluoroacetic acid d, 250MHz)t 9.45 (s, 1H), 8.5 (d, 1H, J = 9Hz), 8.4 (d, 1H, J = 6Hz), 8.2 (d, 2H, J = 6.5 Hz), 7.95 (d, 2H, J = 6.5Hz), 5.0 (q, 2H), 1.8 ft, 3H, J s 6.5Hz), Anal.: Calcd. for C18H15FN2O5S.0. 5H2O: C, 54.10; H, 4.01, N, 7.018. Found: C, 53.59; H, 4.00; N, 6.71%. EXAMPLE 11 Ethyl 6,8-Difluoro-7-(3-methoxyphenyl)-1-ethyl 1,4-dihydroquinol-4-one 3-carboxylate A. 471 mg (60% yield) was prepared by the method of Example 2 using 935 mg of 1-bromo-3-methoxybenzene, 5 ml 2M t-butyl lithium solution, 818 mg anhydrous zinc chloride, 720 mg ethyl 7-bromo-6,8-difluro-1-ethyl-1,4- dihydroquinol-4-one 3-carboxylate and 248 mg tetrakis- (triphenylphosphine) palladium. NMR (CDCl3, 60MHz): 8.4 (s, 1H), 8.1 (dd, 1H, J = 9 and 2Hz), 7.6 - 6.9 (m, 4H), 4.4 (2q, 4H, J = 6.5Hz), 3.8 (s, 3H), 1.5 (t, 3H, J = 6.5Hz), 1.4 (t, 3H, J = 6.5Hz). MS: Calcd. for C21H19F2N04: 387.1285. Found: 387.1257. 6,8-Difluoro-7-(3-methoxyphenyl)-1-ethyl 1, 4-dihydroquinol-4-one 3-carboxylic acid B. 327 mg (76% yield) was prepared by the method of Example lF -from 471 mg ethyl 6,8-difluoro-7-(3methoxyphenyl)-1-ethyl-1,4-dihydroquinol-4-one 3carboxylate and recovered as a white solid of m.p. > 260 C NMR (DMSO-d6, 250MHz: 9.05 (s, 1H), 8.05 (dd, 1H. J=9Hz and 2Hz), 7.5 (t, 1H), 7.15 (m, 2H), 4.65 (m, 2H), 3.85 (s, 3E), 1.45 (t, 3H, J = 6Hz). MS: Calcd. for C19Hl5F2N04: 359.0963. Found: 359.0979. Anal.: Calcd. for C19HlSF2N04: C, 63. SO H, 4.17; N, 3.89%. Found: C, 63,28; H, 4.14; N, 3.85%. EXAMPLE 12 6, 8-Difluoro-7-{ 3-hydroxyphenyl 3-l-ethyl-1, 4- dihydroquinol-4-one 3-carboxylic acid A solution of 292 mg 6,8-difluoro-7-(3-methoxyphenyl)- l-ethyl-l , 4-dihydroquinol-4-one 3-carboxylic acid in 50 ml dichloromethane was stirred at -780C while 8.1 ml of 1M boron tribromide in dichloromethane was added dropwise. The reaction mixture was then allowed to warm slowly to room temperature and it was stirred overnight. The mixture was cooled to 50C and quenched with saturated aqueous sodium bicarbonate. The mixture was filtered and the filter residue was extracted with hot tetrahydrofuran. The organic extracts were evaporated to give a solid residue which was treated with 2M hydrochloric acid. The resulting solid was collected by filtration, washed with water and dried, yielding the required product as a white solid of m.p. > 260 C (217 mg, 77% yield). NMR (DMSO-d6, 250MHz): 9.8 (s, 1H), 9.05 (s, 1H), 8.05 (dd, 1H, J = 9Hz and 2Hz), 7.35 (t, 1H), 6.85 (m, 2H), 4.65 (m, 2H), 3.85 (s, 3E1, 1.45 (t, 3H, J = 6Hz), MS: Calcd. for C18H13F2NO4: 345.0913. Found: 345.0856. Anal.: Calcd. for C18H13F2NO4.0.5H2O: C, Çl.Ol; H, 3.95; N, 3.95%. Found: C, 61.27; H, 3.95; N, 3.90%. EXAMPLE 13 Ethyl 6,8-Difluoro-7-(4-methoxyphenyl)-1-ethyl-1,4 dihydroquinol-4-one 3-carboxylate A. 7.7 g of crude product was prepared by the method of Example 2 using 4.67 g of 1-bromo-4-methoxybenzene, 25 ml 2M t-butyl lithium solution, 3.75 g anhydrous zinc chloride, 7.2 g ethyl 7-bromo-6,8-difluoro-1- ethyl-1,4-dihydroquinol-4-one 3-carboxylate and 1.5 g tetrakis(triphenylphosphine) palladium. A pale yellow solid was recovered of m.p. 171 - 172 C. NMR (CDC13, 60MHz): 8.3 (s, 1H), 8.0 (dd, 1H, J = 9HZ and 2Hz), 7.6 - 6.9 (m, 4R), 4.4 (2q, 4E, J = 6.5Hz), 3.8 (s, 3E), 1.5 (t, 3H, J = 6.5Hz), 1.4 (t, 3H, J = 6.5Hz). MS: Calcd. for C21H19F2N04: 387.1279. Found: 387.1277. 6, 8-Difluoro-7- ( 4-methoxyphenyl ) -l-ethyl-1 , 4- dihydroquinol-4-one 3-carboxylic acid B. A mixture of 7.7 g of crude ethyl 6,8-difluoro-7- (4-methoxyphpenyl)-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylate, 50 ml tetrahydrofuran and 100 ml 1M hydrochloric acid was heated at reflux overnight. The reaction mixture was cooled and the resulting precipitate was collected by filtration, yielding the required product as a white solid (5.38 g, 75% yield) of m.p. 250 - 252 C. NMR (Trifluoroacetic acid-d, 60MHz): 9.2 (s, lH), 8.1 (dd, 1H, J = 9Hz and 2Hz), 7.4 (d,2H, J = 9Hz), 7.0 (d, 2H, J = 9Bz), 4.8 (m, 2H), 3.9 (s, 3H), 1.6 (t, 3H, J = 6.5Hz). MS: Calcd. for C18HlSF2N04: 359.0973. Found: 359.0986. Anal.: Calcd. for C18H15F2NO4.0.5Hz2O; C, 61.96; H, 4.35; N, 3.80%. Found: C, 61.78; H, 4.40; N, 3.60%. EXAMPLE 14 6,8-Difluoro-7-(4-hydroxyphenyl)-1-ethyl-1,4 dihydroquinol-4-one 3-carboxylic acid A solution of 312 rng 6,8-difluoro-7-(4-methoxyphenyl)- 1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid in 40 ml dichloromethane was stirred at -78 C while 8.69 ml of lM- boron tribromide in dichloromethane was added dropwise. The reaction mixture was then allowed to warm slowly to room temperature and it was stirred overnight. The mixture was cooled to 50C and quenched with saturated aqueous sodium bicarbonate. The mixture was extracted with dichloromethane and then several times with a mixture of tetrahydrofuran and ethyl acetate. The latter extracts were evaporated and the resulting solid was stirred with 1M hydrochloric acid for 30 minutes and the product was collected by filtration, washed with water and dried. The required product was a white solid (264 mg, 88% yield) of 2700C. NMR (DMSO-d6, 250MHz): 9.05 (s, lH), 8,0 (d, 1H, J = 9Hz), 7.4 (d, 2H, J = 9Hz), 6.95 (d, 2H, J= 9Hz), 4.65 (m, 2H), 1.45 (t, 3H, J = 6Hz). MS: Calcd. for C18H13F2N04: 345.0813. Found 345.0813. Anal.: Calcd. for C18H13F2NO4.H2O: C, 59.50; H, 4.13; N, 3.85%. Found: C, 59.59; H, 4.07; N, 3.74%. EXAMPLE 15 4-Bromobenzyl dimethyl-t-butylsilyl ether A. A mixture of 18.7 g 4-bromobenzyl alcohol, imidazole (13.6 g), dimethyl-t-butylsilyl chloride {15 g) and N,Ndimethylformamide (100 ml) was stirred at room temperature for 2 hours. The reaction mixture was poured into water and extracted three times with ether. The combined organic extracts was washed with water, brine and dried. Evaporation gave the product as a colorless oil (29.8 g, 99% yield) which was used without further purification. NMR (CDC13, 250MHz): 7.55 (d, 2H, J = 9Hz), 7.25 (d, 2H, J 9Hz), 4.7 (s, 2R), 0.9 Is, 9H), 0.0 (s, 6H). Anal.: Calcd. for C13X2lBrOSi: C, 51.83; H, 6.97%. Found: C, 51.48; H, 6.93%. Ethyl 1-ethyl-6,8-difluoro-7-(4-(dimethyl-t butylsilyloxymethyl)-phenyl)-1,4 dihydroquinol-4-one 3-carboxylate B. 5.1 g (51% yield) was prepared by the method of Example 2 from 7.53 g of 4-bromobenzyl dimethyl-t-butylsilyl ether, 25 ml 2M t-butyl lithium solution, 3.75 g anhydrous zinc chloride, 7.2 g ethyl 7-bromo-6, 8- difluoro-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylate and 1.5 g tetrakis (triphenylphosphine) palladium. The title compound formed had a m.p. of 143 - 144 C. NMR(DMSO-d6, 250MHz): 8.7 (s, 1H), 7.95 (dd, 1H, J = 9 and 2Hz), 7.5 (q, 4H), 4.85 (s, 2H), 4.5 (br m, 2H), 4.25 (q, 2H), 1.45 (t, 3H, J= /Hz), 1.4 (t, 3H, 3 = 7Hz), 0.95 (s, 9H), 0.15 (s, 6H). Anal.: Calcd. for C27H33F2N04Si: C, 64.67; H, 6.58; N, 2.79%. Found: C, 64.75; H, 6.72; N, 2.78%. Ethyl 1-ethyl-6,8-difluoro-7-(4-hydroxymethylphenyl) 1,4-dihydroquinol-4-one 3-carboxylate C. A mixture of 5.1 g ethyl l-ethyl-6,3-difluoro-7- (4-(dimethyl-t-butylsilyloxymethyl)-phenyl)-1,4dihydroquinol-4-one 3-carboxylate and 10.2 ml of IM tetra-n-butylammonium fluoride in tetrahydrofuran was stirred at room temperature for 2 hours. The reaction mixture was poured into water and extracted three times with ether and once with chloroform. The combined organic extracts were dried and evaporated to yield the product as a yellowish solid of m.p. 230 - 2320C (3.8 g, 96% yield). NMR (DMSO-d6, 250MHz): 8.7 (s, lR), 7.9 (dd, 1H, J = 2Hz and 10Hz), 7.5 (s, 4H), 4.6 (d, 2H), 4.5 (m, 2H), 4.25 (q, 2H, J=6.5Hz), 1.45 (t, 3H, J 6.5Hz), 1.35 (t, 3H, J=6.5Hz). MS: Calcd. for C21H19F2N04: 387.1279. Found 387.1275. 1-Ethyl-6,8-difluoro-7-(4-hydroxymethylphenyl)-1,4 dihydroquinol-4-one 3-carboxylic acid D. 600 mg (43% yield) was prepared by the method of Example 13B from 1.5 g ethyl 1-ethyl-6,8-difluoro-7- (4-hydroxymethylphenyl)-1,4-dihydroquinol-4-one 3-carboxylate as a white solid of m.p. 269*C. NMR (DMSO-d6, 250MHz): 9.05 (s, 1H)m 8.05 (dd, 1H, J 2Hz and 9Hz), 7.55 fs, 4H), 5.35 (t, 1H, J 5 4Hz), 4.65 (m, 2H), 4.6 (d, 2H, J = 4Hz), 1.45 (t, 3H, J - 6Hz). MS: Calcd. for C19R15F2N04: 359.0965. Found: 359.0972. Anal.: Calcd. for C19H15F2N04: C, 63.51; H, 4.18; N, 3.908. Found: C, 63.15; H, 4.21; N, 3.66%. EXAMPLE 16 3-Bromobenzyl dimethyl-t-butylsilyi ether A. A mixture of 5.0 g 3-bromobenzyl alcohol, imidazole (3.64 g), dimethyl-t-butylchlorosilane (4.02 g) and N,N-dimethylformamide (25 ml) was stirred at room temperature for 2 hours. The reaction mixture was poured into water and extracted three times with ether. The combined organic extract was washed with water, brine and dried. Evaporation gave the product as a colorless oil (6.83 g, 85% yield) which was used without further purification. Ethyl l-ethyl-6,8-difluoro-7-(3-(dimethyl-t butylsilyloxymethyl)-phenyl)-1,4 dihydroquinol-4-one 3-carboxylate B. 7.0 g (87% yield) was prepared by the method of Example 2 from 6.82 g of 3-bromobenzyl dimethyl-t- butylsilyl ether, 25 ml 2M t-butyl lithium solution1 3.4 g nhydrous zinc chloride, 5.9 g ethyl 7-bromo6,8-diluoro-1-ethyl-1,4-dihydroquinol-4-one 3carboxylate and 1.5 g tetrakis(triphenylphosphine) palladium. The melting point was 107 - 1090C. NMR (DMSO-d6, 250MHz): 8.7 (s, 1H), 7.92 (dd, 1H, J = 9 and 2Hz), 7.49 (m, 4H), 4.82 (s, 2H), 4.47 (m, 2E), 4.26 (q, 2H), 1.42 (t, 3H, J=7Hz), 1.3 (t, 3H, J = 7Hz), 0.94 (s, 9H), 0.1 (s, 6H). Anal.: Calcd. for C27H33F2N04Si: C, 64.67; H, 6.58; N, 2;79%. Found: C, 64.51, H, 6.59; N, 2.75%. Ethyl 1-ethyl-6,8-difluoro-7-(3-hydroxymethylphenyl) 1, 4-dihydroquinol-4-one 3-carboxylate C. 4.2 g (78% yield) was prepared by the method of Example 15C from 7.0 g of ethyl l-ethyl-6,8-difluoro- 7-(3-(dimethyl-t-butylsilyloxymethyl)-phenyl)-1,4dihydroquinol-4-one 3-carboxylate and 14 ml of 1M tetra-n-butylammonium fluoride in tetrahydrofuran. A yellow solid of m.p. 162 -166 C was recovered. NMR (DMSO-d6, 250MHz): 8.7 (s, 1H), 7.95 (dd, 1R, J = 2Hz and 9Hz), 7.5 (m, 4E), 5.3 (t, 3H, J = 6Hz), 4.6 (d, 2H,J = 6Ez), 4.5 (m, 2H), 4.25 (q, 2H, J = 6.5Hz), 1.45 (t, 3H, J = 6.5Hz), 1.3 (t, 3H, J = 6.5Hz). MS: Calcd. for C21H19F2NO4: 387.1279. Found: 387.1280. l-Ethyl-6, 8-difluoro-7-(3-hydroxymethylphenyl) 1,4-dihydroquinol-4-one 3-carboxyl ic acid D. 330 mg (92% yield) was prepared by the method of Example 13B from 387 mg ethyl l-ethyl-6,8-difluoro-7 (3-hydroxymethylphenyl)-1,4-dihydroquinol-4-one 3-carboxylate as a white solid of m.p. 230 - 2310C. NMR (DMSO-d, 250MHz): 9.1 (s, 1H), 8.05 (dd, 1H, J 9Hz and 2Hz), 7.5 (m, 4H), 4.65 (m, 2H), 4.6 (s, 2E), 1.45 (t, 3R, J - 6Hz). Anal.: Calcd.: Cor C19H15F2NO4.0.5H2O: C, 61.95; H, 4.35; N, 3.80%. Found: C, 61.89; H, 4.50; N, 3.48%. EXAMPLE 17 Ethyl 1-ethyl-6,8-difluoro-7-(4-azidomethylphenyl) 1,4-dihydroquinol-4-one 3-carboxylate A. A solution of 585 mg methanesulfonyl chloride in 20 ml dichloromethane was added dropwise to a stirred solution of 15 ml triethylamine and 1.8 g ethyl l-ethyl 6,8-difluoro-7-(4-hydroxymethylphenyl)-1,4-dihydroquLnol- 4-one 3-carboxylate in 100 ml dichloromethane at 0'C. After the addition was complete, the reaction mixture was extracted with 120 ml water and the organic phase was dried and evaporated to yield the mesylate product which was used directly without further purification. This mesylate was dissolved in acetone containing 605 mg sodium azide. Water was added dropwise until solution of the azide was complete. The reaction mixture was stirred overnight at room temperature. The reaction mixture was partitioned between water and dichloromethane and the aqueous phase was extracted twice more and the combined organic extracts were washed with water and brine and dried. Evaporation gave the crude product which was purified by elution on silica gel yielding pure product as a solid of m.p. 149.5 - 150 C (850 mg, 44% yield). NMR (D!SO d6, 250MHz): S.7 (s, 1H), 7.95 (dd, 1H), J - 2Hz, and 9Hz), 7.6 (ABq, 4H), 4.6 (s, 2H), 4.5 (m, 2H), 4.25 (q, 3H), J = 6.5Rz), 1.45 (t, 3H, J = 6.5Hz), 1.35 (t, 3 , J= 6.5Hz). MS: Calcd. for C21H18F2N403: 412.1343. Found: 412.1344. Anal.: Calcd. for C21H18F2N403: C, 61,16; H, 4.37; N, 13.59%. Found: C, 61.65; H, 4.55; N, 13.13%. Ethyl 1-ethyl-6,8-difluoro-7-(4-aminomethylphenyl) 1, 4-dihydroquinol-4-one 3-carboxylate B. A solution of 2.6 g ethyl 7-(4-azidomethylphenyl)- 1-ethyl-6,8-difluoro-1,4-dihydroquinol-4-one 3-carboxy late in 50 ml methanol and 100 ml chloroform, containing 1.3 g 5% palladium on charcoal was hydrogenated at 12 p.s.i. for 2 hours. The reaction mixture was filtered and the filtrate was evaporated. The residue was triturated with a small quantity of chloroform and dried, yielding 2.2 g of the product as a solid (92% yield), m.p. 262 - 263 C. NMR (DMSO-d6, 250MHz): 8.72 (s, 1H), 8.5 (br 5, 2H), 7.95 (dd, 1H, J = 2 and 9Hz), 7.65 (q, 4E), 4.49 (br m, 2H), 4.3 (q, 2H), 4.13 (s, 2H), 1.42 (t, 3H, J= 7Hz), 1.3 (t, 3E, J = 7Hz). MS: Calcd. for C21H20F2N203: 386.1437. Found: 386.1448. 1-Ethyl-6,8-difluoro-7-(4-aminomethylphenyl) 1, 4-dihydroquinol-4-one 3-carboxylic acid hydrochloride salt C. 135 mg (79.38 yield) was prepared by the method of Example 133 from 450 mg ethyl 7-(4-aminomethylphenyl)- 1-ethyl-6,8-difluoro-1,4-dihydroquinol-4-one 3 carboxylate. White solid of m.p. > 280 C. NMR IDMSO d6, 250MHz): 9.1 (s, 1H), 8.1 (dd, 1H, J=2Hz and 9Hz), 7.7 (ABqt, 4H), 4.65 (m, 2H), 4.15 (s, 2E}, 1.45 (t, 3H, J = 6.5 Hz). MS: Calcd. for C19H16F2N203: 358.1129. Found: 358.1169 Anal.: Calcd. for C19H16F2N203. HCl. 2H20: C, 53.02; X, 4.88; N, 6.51%. Found: C, 53.66; H, 4.35; N, 6.60%. EXAMPLE 18 Ethyl 1-ethyl-6,8-difluoro-7-(3-azidomethylphenyl) 1, 4-dihydroquinol-4-one 3-carboxylate A. 2.28 g (54% yield) was prepared by the method of Example 17A using 1.3 g methanesulfonyl chloride in 25 ml dichloromethane, added to a solution of 25 ml triethylamine and 4.0 g ethyl l-ethyl 6,8-difluoro-7- (3-hydroxymethylphenyl)-1,4-dihydroquinol-4-one 3 carboxylate in 100 ml dichloromethane at 0 C, followed by 5.36 g sodium azide in 150 ml acetone. The product formed was a solid of m.p. 119 C. NMR (DMSO-d6, 250MHz): 8.7 (s, 1H), 7.9 (dd, 1H, J = 2Hz and 9Hz), 7.55 (m, 4H),' 4.6 (s, 2H), 4.5 (m, 2H), 4.25 (q, 2H, J = 6.5Hz), 1.45 (t, 3E, J = 6.5Hz), 1.3 (t, 3H, J X 6.5Rzi. MS: Calcd. for C21H18F2N403: 412.1343. Found: 412.1363. Anal.: Calcd. for C21H18F2N403: C, 61.16; H, 4.37; N, 13.598. Found: C, 61.27; H, 4.58; N, 12.77%. Ethyl 1-ethyl-6,8-difluoro-7-(3-aminomethylphenyl) 1,4-dihydroquinol-4-one 3-carboxylate B. 200 mg (85% yield) was prepared by the method of Example 17B from 250 mg ethyl 1-ethyl-6,8-difluoro-7 (3-azidomethylphenyl)-1,4-dihydroquinol-4-one 3-carboxylate. A pale brown solid was formed, m.p. 260 - 262 C. NMR (DMSO-d6, 250MHz): 8.72 (s, 1H), 8.4 (br s, 2H), 7.97 (br d, 1H, J=9Hz), 7.65 (m, 4H), 4.49 (br m, 2H), 4.27 (q, 2H), 4.12 (s, 2H), 1.45 (t, 3H, J - 7Hz), 1.32 (t, 3R, J = 7Hz). MS: 386 (parent), 314 (base). 1-Ethyl-6,8-difluouro-7-(3-aminomethylphenyl) 1,4-dihydroquinol-4-one 3-carboxylic acid hydrochloride salt C. 135 mg (79.3% yield) was prepared by the method of Example 13B from 450 mg ethyl l-ethyl-6,8-difluoro-7 (4-aminomethylphenyl-1,4-dihydroquinol-4-one 3-carboxylate. White solid of m.p.) 280 C. NMR (DMSO-d6, 250 MHz): 9.1 (s, 1H), 8.1 (dd, 1H, J - 2Hz and 9Hz), 7.65 (m, 4H), 4.65 (m, 2H), 4.1 (s, 2H), 1.45 (t, 3H, J 6.5Hz). MS: Calcd. for C19R16F2N203: 358.1129. Found: 358.1172. Anal.; Calcd. for C19H16F2N203.HCl.1.5H2O: C, 56.57; H, 4.46; N, 6.95%. Found: C, 56.80; H, 4.47; N, 6.998. EXAMPLE 19 3-(2-Fluorophenyl)-toluene A. A 1.46M solution (45 n.l) of toluylmagnesium bromide in ether was added to a mixture of 10 g 2-bromofluorobenzene and 250 mg bis(diphenylphosphinoethane)-nickel dichloride in 70 ml dry diethyl ether. The mixture was then heated at reflux for 18 hours. The mixture was cooled to room temperature and quenched with 10% aqueous ammonium chloride, followed by 1M hydrochloric acid, and then partitioned between ether and water. The aqueous phase was extracted once more with ether and the combined organic extracts were dried and evaporated yielding the crude product as an oil which was purified by elution from silica gel with hexanes. The product was a colorless oil (7.0 g, 66% yield) which was used without further purification. NMR (CDC13, 60MHz): 7.4 6.9 (m, 8H), 2.4 (s, 3H). 3- ( 2-Fluorophenyl ) -benzoic acid B. A mixture Of 7.0 g 3-(2-fluorophenyl)-toluene and 29.5 g potassium permanganate in 500 ml t-butanol and 100 ml water was heated at 90 C for 18 hours. The reaction mixture was cooled to room temperature, sufficient sodium bisulfite was added to dissolve the remaining potassium permanganate and manganese dioxide, and the pH was adjusted to 1 with hydrochloric acid. The resulting precipitate was collected by filtration, redissolved in ethyl acetate and this solution was dried and evaporated yielding the product as a white solid of m.p. 147 - 1480C after recrystallization from hexanes (5.7 g, 70% yield). NMR (DMSO-d6, 250MHz): 8.2 - 7.3 (m, 8E}. MS: Calcd. for C13H9F20: 216.0585. Found: 216.0585. 3-(2-Fluoro-5-nitrophenyl)-benzoic acid C. A solution of 420 mg potassium nitrate in 5 ml concentrated sulfuric acid was added dropwise to a stirred solution of 1 g 3-(2-fluorophenyl)-benzoic acid in 25 ml concentrated sulfuric acid at 0 C. The mixture was stirred at 0 C for 20 minutes and then poured into iced water. The real ting precipitate was extracted into ethyl acetate and the extracts were combined, dried and evaporated, yielding the product as a white solid (1.2 g, 1008 yield), m.p. 272 2740C after recrystallization from ethyl acetate. NMR (DMSO-d6, 250 MHz): 8.4 (m, 2H), 8.16 (d, 1H, J= 2Hz), 8.05 (multiplets, 1H), 7.9 (multiplets, 1H), 7.66 (m, 2R), 3.4 (br s, 1H). MS: Calcd. for C13H8NF04: 261.0438. Found: 261.0416. Anal.: Calcd. for C13H8NF04.1/4H2O: C, 58.75; H, 3.20; N, 5.27%. Found: C, 58.84; H, 3.19i N, 5.12%. 3-(2-Fluoro-5-nitrophenyl)-benzyl alcohol D. A 1M solution (200 ml) of diborane in tetrahydrofuran was added to a stirred solution of 3-(2-fluoro S-nitrophenyl)-benzoic acid (6.6 g) in 500 ml tetrahydrofuran. the reaction mixture was stirred at room temperature for 12 hours and then quenched with water and extracted with ethyl acetate. The organic extracts were dried and evaporated to yield a yellow solid which was purified by elution on silica gel with 40% ethyl acetate/hexanes. This gave the pure required product as a yellow solid (4.04 g, 65% yield), m.p. 113 - 1140C. NMR (CDC13, 250MHz): 8.42 (four line multiplet, 1H), 8.25 (8 line multiplet, 1H), 7.55 (m, 4z), 7.3 (four line multiplet, 1H), 4.8 (d, 2H, J 4.5Hz), 0.9 (t, 1H). MS: Calcd. for C13H10FN03: 247.0645. Found: 247.0647. Anal.: Calcd. for Cl3Hl0FNO3: C, 63.16; H, 4.05; N, 5.67%. Found: C, 63.42; H, 4.11; N, 5.538. 3-(3-t-Butyldimethylsilyloxymethylphenyl) 4-fl uoronitrobenzene E. A mixture of 4.04 g 3-(2-fluoro-5-nitrophenyl)benzyl alcohol, 2.23 g imidazole and 2.46 g t-butyldimethyl- silylchloride in 100 ml N,N-dimethylformamide was stirred at rodm temperature for 30 minutes. The reaction mixture was then partitioned between water and ether. The combined organic extracts were washed three times with water, dried and evaporated yielding the product as a yellow oil (5.9 g, 99% yield) which was purified on silica gel to give a yellow solid of m.p. 44 - 450C. NMR (CDC13, 250MHz): 8.4 (dd, 1H), 8.34 (eight line multiplet, 1H), 7.5 (m, 4E), 7.3 ( 3, 4.83 (s, 2H), 0.95 (s, 9H), 0.15 (s, 6H). Anal.: Calcd. for C18E21FN03Si: C, 63.16; H, 6.65; N, 3.88%. Found: C, 62.99; H, 6.62; N, 3.82%. 3-( 3-t-Butyldimcthylsilyloxymethylphenyl )- 4-fluoroaniline F. A solution of 5.92 g 3-(3-t-butyldimethylsilyloxymethylphenyl)-4-fluoronitrobenzene in 200 ml 50% ethyl acetate/hexanes was hydrogenated over 5 g of 5% palladium on carbon at 50 p.s.i. for 15 minutes. The reaction mixture was filtered and evaporated to yield the crude product (5.43 g, 100% yield) which was used directly without further purification. On purification, the compound is characterized by the following data: NMR (CDC13, 250MHz): 7.45 (m, 4R), 6.98 (dd, 1R), 6.75 (dd, 1H), 6.62 (8 line multiplet, lH), 4.8 (s, 2E), 3.6 (br s, 2H), 0.95 (s, 9H), 0.01 (s, 6H). MS: Calcd. for C19H29FNOSi; 331.1768. Found: 331.1776, Anal.: Calcd. for C19H29FNOSi: C, 68.88; H, 7.86; N, 4.238. Found: C, 69.15; H, 8.18; N, 4.14%. Diethyl (3-(3-t-butyldimethylsilyloxymethylphenyl) 4-fluoronitroanilino)methylene malonate G. A mixture of 5.4 g 3-(3-t-butyldimethylsilyloxy- methylphenyl)-4-fluoroaniline and 3.9 ml diethyl ethoxymethylenemalonate ere heated at 1500C for 15 minutes. The mixture was cooled and the resulting oil was purified by elution on silica gel with 25% ethyl acetate/hexanes to give the product as a clear pale green oil (90% yield). NMR (CDCl3, 250MHz): 11.1 (dt lH, J = 9Hz), 8.5 (d, 1H, J = 9Hz), 7.45 (m, 5H), 7.2 (m, 2H), 4.82 (s, 2H), 4.3 (m, 4E), 1.35 (m, 6H), 0.95 (s, 9E}, 0.15 (s, 6H). MS: Calcd. for C27H36FNO5Si: 501.2346. Found; 501.2344. Anal.: Calcd. for C27H36FN05Si: C, 64.67; H, 7.19; N, 2.79%. Found: C, 64.47; H, 7.06; N, 2.97%. Ethyl 7- ( 3-t-butyldimethyl silyloxymethylphenyl ) 6-fluoro-4-hydroxyquinol ine 3-carboxylate H. A mixture of diethyl (3-(3-t-butyldimethylsilyloxymethylphenyl)-4-fluoronitroanilino)methylene malonate (2.4 g) in 18 ml Dowtherm A was heated at 2600C for 2.5 hours. The reaction mixture was cooled and triturated with- hexanes yielding the product as a white solid (1.13 g, 52% yield), m.p. 310 - 312 C with decomposition. NMR (1% DMSO-d6/TFA-d, 250MHz): 9.4 (m, 1H), 8.38 (m, 2H), 7.83 (m, 2H), 7.65 (m, 2R), 5.55 (s, 2R), 5,0(s, 1H), 4.68 (q, 2E), 1.55 (t, 3H), 1.01 (s, 9H), 0.4 (s, 6H). Ethyl 7-(3-t-butyldimethylsilyloxymethylphenyl) 1-ethyl-6-fluoro-1,4-dihydroquinol-4-one 3-carboxylate I. A mixture of 1.13 g ethyl 7-(3-t-butyldimethylsilyl- oxymethylphenyl)-6-fluoro-4-hydroxyquinoline 3-carboxylate, 3 ml iodoethane and 1.5 g potassium carbonate in 50 ml N,N-dimethylformamide was stirred at room temperature for 24 hours. The reaction mixture was partitioned between ethyl acetate and water. The ethyl acetate layer was washed four times with water and dried. Evaporation gave the crude product which was eluted on silica gel with ethyl acetate/hexanes to yield the pure product as a pale yellow oil (1.02 g, 85% yield). NMR (CDC13, 250MHz): 8.55 (s, r 8.3 (d, IR, J= 11Hz), 7.5 (m, 5H), 4.85 (s, 2H), 4.45 (q, 2H, J X 6.5Hz), 4.3 (q, 3H, z = 6.5Hz), 1.6 (t, 3H, J = 6.5Hz), 1.45 (t, 3H, J = 6.5Hz), 1.0 (s, 9H), 0.0 (s, 6H). Ethyl 1-ethyl-6-fluoro-7-(3-hydroxymethylphenyl) 1,4-dihydroquinol-4-ono 3-carboxylate J. A 1M solution (2.11 ml) of tetra-n-butylammonium fluoride in tetrahydrofuran was added to a solution of 1.02 g ethyl 7-(3-t-butyldimethylsilyloxymethylphenyl)1-ethyl-6-fluoro-1,4-dihydroquinol-4-one 3-carboxylate in 20 ml tetrahydrofuran. After 15 minutes, the solution was pa-rtiti?ned between ethyl acetate and water. The organic c extracts were dried and evaporated to give the product as a white. solid (755 mg, 97% yield). 1-Ethyl-6-fluoro-7-(3-hydroxymethylphenyl) 1,4-dihydroquinol-4-one 3-carboxylic acid K. A mixture of 755 mg ethyl l-ethyl-6-fluoro-7- (3-hydroxymethylphenyl)-1,4-dihydroquinol-4-one 3-carboxylate 50 ml 1M sodium hydroxide and 5 ml tetrahydrofuran were heated at 900C for 30 minutes. The solution was coqled and acidified to pH 1 with 6M hydrochloric acid. The resulting precipitate was collected by filtration, washed with water and dried, yielding the product as a white solid of m.p. 203 204 C (587 mg; 84% yield). NMR (DMSO-d6, 250MHz): 9.1 (s, 1H), 8.1 (m, 2H), 7.5 (m, 4E), 4.7 (q, 2H), 4.6 (d, 2H, J = 7Hz), 1.45 (t, 3H, J = 6.5 Hz). MS: Calod. for C19H16FNO4: 341.1064. Found: 341.1060. Anal.: Cald. for Cl9H16FNO4.0.25H20: C, 65.99; H, 4.78; N, 4.05%. Found: C, 66.09; R, 5.16; N, 3.918. EXAMPLE 20 4-(2-Fluorophenyl)-toluene A. 6.0 g (57% yield) was prepared as an oil by the method of Example 19A from 10 g 2-bromofluorobenzene, 250 mg bis(diphenylphosphinylethane)nickel dichloride and 89 ml 0.73M 4-toluylmagnesium bromide. The product was used without further purification. teR (CDC13, 60MHz): 7.5 - 6.9 (m, 8E), 2.3 (s, 3H). 4- ( 2-Fluorophenyl ) -benzoic acid B. 1.17 g (1008 yield) was prepared by the method of Example 19B from 1.0 g 4-(2-fluorophenyl)-toluene and a white solid of m.p. 226 - 2270C was recovered. NMR (DMSO-d6, MHz) 8.1 (d, 2E), 7.8 - 7.3 (m, 6H). 4-(2-Fluoro-5-nitrophenyl)-benzoic acid C. 1.2 g (100% yield) was prepared by the method of Example 19C from 1.0 g 4-(2-fluorophenyl)-benzoic acid. White solid of m.p. > 2800C. NMR (DMSO-d6, 250MHz): 8.5 - 7.6 (m, 7H), MS: Calcd. for C13H8NF04: 261.0438. Found: 261.0457. 4-(2-Fluoro-5-nitrophenyl)-benzyl alcohol D. 700 mg (61% yield) was prepared by the method of Example 19D from 1.2 g 4-(2-fluoro-5-nitrophenyl)- benzoic acid, Pale yellow solid of m.p. 106 - 108.50C. NMR (CDCl3, 250MHz): 8.4 (m, lH), 8.2 (m, lH), 7.55 (ABq, 4E), 7.3 (m, 1H), 4.8 (d, 2H, J = 6Hz). 3-(4-t-Butyldimethylsilyloxymethylphenyl) 4-fluoronitrobenzene E. 6.0 g (98% yield was prepared by the method of Example 19E from 4.2 g 4-(2-fluoro-S-nitrophenyl)- benzyl alcohol, 2.5 g imidazole and 3.5 g t-butyldimethylsilyl chloride. The oil was used without further purification. 3-(4-t-butyldimethylsilyloxymethylphenyl) 4-fluoroanil ine F. 5.5 g was prepared by the method of Example 19F from 6.0 g 3-(4-t-butyl-dimethylsilyloxymethylphenyl)- 4-fluoronitrobenzene. The formed oil was used without further purification. Diethyl (3-(4-t-butyldimethylsilyloxymethylphenyl) 4-fluoroanilino)methylenemalonate G. 5.12 g (60% yield) was prepared by the method of Example 19G from 5.5 g 3-(4-t-butyldimethylsilyloxy- methylphenyl)-4-fluoroaniline and 3.5 ml diethyl ethoxymethylenemalonate. A pale yellow-green oil was obtained. NMR (CDC13, 250MHz): 8.5 (d, 1H, J = 12Hz), 7.5 (ABq, 4E), 7.2 (m, 3H), 4.8 Is, 2E), 4.25 (m, 4H), 1.35 (m, 6H), 1.0 (s, 9H), t.1 (st 6H). Ethyl 7-(4-t-butyldimethylsilyloxymethylphenyl)-6 fluoro-4-hydroxyquinoline 3-carboxylate H. 379 mg (42% yield) was prepared by the method of Example 19H from 1.0 g diethyl (3-(4-t-butyldimethyl- silyloxymethylphenyl ) -4-fluoroanilino) methyl enemalonate. A white solid of m.p. > 2800C. was recovered. Ethyl 7-(4-t-butyldimethylsilyloxymethylphenyl)-1 ethyl-6-fluoro-1,4-dihydroquyino-4-one 3-carboxylate 1. 233 n.g {588 yield) was prepared as a solid of m.p. 158 - 1600C by the method of Example l9I from 379 mg ethyl 7-(4-t-butyldimethylsilyloxymethylphenyl) 6-fluoro-4-hydroxyquinoline 3-carboxylate. NMR (CDC13, 250MHz): 8.5 (s, 1R), 8.2 (d, 1H, J s 11Hz), 7.5 (ABq, 4H), 7.45 (d, 1H), 4.8 (s, 2H), 4.4 (q, 2H, J = 6.5Hz), 4.3 (q, 2H, J = 6.5Hz), 1.55 It, 3H, J X 6.5Hz), 1.4 (t, 3H, J = 6.5Hz), 1.0 (s, 9H), 0,1 (s, 6H). Ethyl 1-ethyl-6-fluoro-7-(4-hydroxymethylphenyl)-1,4 dihydroquinol-4-one 3-carboxylate J. 170 mg (97% yield) was prepared by the method of Example 19J from 230 mg ethyl 7-(4-t-butyldimethylsilyloxymethylphenyl)-1-ethyl-6-fluoro-1,4-dihydroquinol-4-one 3-carboxylate as a white solid which was used without further purification. 1-Ethyl-6-fluoro-7-(4-hydroxymethylphenyl)-1,4 dihydroquinol-4-one 3-carboxylic acid R. 155 mg (95% yield) was prepared by the method of Example l9R from 170 mg ethyl I-ethyl-6-fluoro-7- (4-hydroxymethylphenyl)-1,4-dihydroquinol-4-one 3-carboxylate. A white solid of m.p 220 - 2210C was recovered after recrystallisation from dimethyl formamide. NMR (DMSO-d6, 25 OMHz): 9.1 (s, 1H), 8.1 (dd, 2H), 8.6 (ABq, 4E), 4.7 (q, 2H), 4.6 (s, 2B), 1.45 (t,-3H, J = 6.5Hz). EXAMPLE 21 Ethyl 1-ethyl-6-fluoro-7-(4-formylphenyl)-1,4 dihydroquinol-4-one 3-carboxylate A. Oxalyl chloride (171 mg) was added dropwise to a solution of ethyl l-ethyl-6-fluoro-7-(4-hydroxymethylphenyl)-1,4-dihydroquinol-4-one 3-carboxylate (450 mg') in 8 ml dichloromethane and 2 ml dimethyl sulfoxide at -780C. After 25 minutes, 0.9 ml triethylamine was added, the mixture warmed to room temperature and partitioned between water and ethyl acetate. The organic phase was dried and concentrated to a small volume. The product was precipitated by addition of diethyl ether as a white solid of m.p. 165 - 1700C (360 mg, 80% yield). NMR (CDCl3, 25OMHz): 10.1 (s, 1H), 8.55 (s, 1H), 8.3 (d, 1H, J = 11Hz), 8.0 (d, 2H, J = 9Hz), 7.75 (d, 2fl, J = 9Hz), 7.5 (d, 1H, J = 6Hz), 4.4 (2q, 4H), 1.6 (t, 3H, 3 = 6.5Hz), 1.45 (t, 3R, J - 6.5Hz). MS: Calcd. for C21H18NO4F: 367.1220. Found: 367.1230. 1-Ethyl-6-fluoro-7(4-formylphenyl)-1,4 dihydroquinol-4-one 3-carboxylic acid B. 63 mg (628 yield) was prepared by the method of Example 19K from 110 mg ethyl l-ethyl-6-fluoro-7-(4- formylphenyl)-1,4-dihydroquinol-4-one 3-carboxylate as a white solid of m.p. > 270 C. NMR (DMSO-d6/Trifluoroacetic acid-d, 250MHz): 9.45 (s, 1H), 8.5 (d, 1H, J = 11Hz), 8.4 (d, 1H, J = 6Hz), 8.2 (d, 2H, J = 9Hz), 8.0 (d, 2H, J = 9Hz), 5.0 (m, 2H), 1.8 (t, 3H, J = 6.5 Hz). MS: Calcd. for Cl9H14FNO4; 339.0908. Found: 339.0872. Anal. Calcd. for C19H14FN04: C, 67.26; H, 4.13; N, 4.13%. Found: C, 67.08; H, 4.45; N, 4.04%. EXAMPLE 22 4-Bromo-2-chloroanisole A. A solution of 4-bromo-2-chlorophenol (5.18 g) in 20 ml tetrahydrofuran was added dropwise to a stirred mixture of sodium hydride (0.72 g) in tetrahydrofuran (50 ml). After 30 minutes, iodomethane (4.26 g) was added and the mixture was stirred overnight at room temperature. A further 7.1 g of iodomethane was added and the mixture was heated at reflux overnight. The reaction mixture was then partitioned between water and chloroform. The combined organic extracts were dried and evaporated to yield the product after washing with hexanes as a white solid (5.4 g, 98% yield) of m.p. 63 C. Anal.: Calcd. for C7H6BrClO: C, 38.00; H, 2.71%. Found: C, 38.07; H, 2.80%. Ethyl 1-ethyl-7-(3-chloro-4-methoxyphenyl)-6,8 difluoro-1, 4-dihydroquinol-4-one 3-carboxylate B. 300 mg (35.5% yield) was prepared by the method of Example 2 using 1.11 g 4-bromo-2-chloroanisole, 5 ml 2M t-butyl lithium solution, 750 mg zinc chloride and 720 mg ethyl 7-bromo-6,8-difluoro-1-ethyl-1,4-dihydro- quincl-4-one 3-carboxylate and 100 mg tetrakis(triphenyl- phosphine)palladium. A yellow solid of m.p. 280 CC. was recovered. NMR (CDC13, 250MHz): 8.45 (s, lH), 8.15 (dd, 1H, J = 2Hz and 9Hz), 7.55 (s, 1H), 7.4 (m, 1H), 7.1 (d, IR, J = 9Hz), 4.4 (2q, 4H), 4.0 (s, 3H), 1.55 (t, 3H, J = 6.5Hz), 1.45 (t, 3H, J = 6.5Hz). Anal.: Calcd. for C21H18ClF2NO4.0.5H20: C, 58.00; H, 4.41; N, 3.25%. Found: C, 59.06; H, 4.52; N, 3.17%. 7-(3-chloro-4-methoxyphenyl)-6,8-difluoro-1 ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid C. 250 mg (90% yield) was prepared by the method of Example 133 from 300 mg of ethyl 1-ethyl-7-(3-chloro-4- methoxyphenyl)-6,8-difluoro-1,4-dihydroquinol-4-one 3-carboxylate. A white solid was recovered having a m.p. > 280 C. Anal.: Calcd. for Cl9H14ClF2NO4.1/3H2O: C, 57.14; H, 3.67; N, 3.50%, Found: C, 57.16; H, 3.69; N, 3.22%. NMR (DMSO-d6, 250MHz): 9.05 (s, 1H), 8.05 (dd, 1H, 9Hz and 2Hz), 7.7 (s, lH), 7.55 (m, 1H), 7.35 (d, 1H, J = 9Hz), 4.65 (m, 2H), 3.95 (s, 3H), 1.45 (t, 3H, J = 6.5Hz). EXAMPLE 23 7-(3-chloro-4-hydroxyphenyl)-6,8-difluoro-1-ethyl 1,4-dihydroquinol-4-one 3-carboxylic acid 40 mg t218 yield) was prepared by the method of Example 14 from 200 mg of 7-(3-chloro-4-methoxyphenyl)- 6,8-difluoro-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid. Yellow solid of m.p. 235 - 2380C. NMR (DMSO-d6, 250MHz): 9.05 (s, 1H), 8.05 (dd, 1H, J - 2Hz and 9Hz), 7.65 (s, 1H), 7.4 (d, 1H, J = 9Hz), 7.15 (d, 1H, J = 9 Hz), 4.65 (m, 2H), 1,45 (t, 3H, J 6.5 Hz). MS: Calcd. for C18H12CiF2N04: 379.0423. Found: 379.0423. EXAMPLE 24 Ethyl 6,8-difluoro-1-ethyl-7-(2-methoxyphenyl) 1,4-dihydroquinol-4-one 3-carboxylate A. 504 Mg (65% yield) was prepared by the method of Example 2 using 935 mg of 2-bromoanisole, 5 ml 2M t-butyl lithium, 818 mg anhydrous zinc chloride, 720 mg ethyl 7-bromo-6,8-difluoro-1- , 4-dihydrquinoI-4-one 3-carboxylate and 248 mg tetrakis(triphenylphosphine)palladium. NMR (CDCl3, 250MHz): 8.4 (s, 1H), 8.0 (dd, 1H, J = 2Hz and 9Hz), 7.2 (m, 4H), 4.4 {2q, 4R), 3.8 (s, 3E), 1.5 (t, 3H, J w 6Hz), 1.4 (t, 3H, J w 6Hz). MS: Calcd. for C21H19F2N04: 387.1285 Found: 387.1306. 6,8-Difluoro-1-ethyl-7-(2-methoxyphenyl)-1,4 dihydroquinol-4-one 3-carboxylic acid 3. 343 Mg (74% yield) was prepared by the method of Example 1F from 500 mg ethyl 6,8-difluoro-l-ethyl-7- (2-methoxyphenyl)-1,4-dihydroquinol-4-one 3-carboxylate as a white solid of m.p. > 260 C. Anal.: Calcd. for Cl9H15F2NO4.1H20: C, 60.47; H, 4.50; N, 3.71%. Found: C, 60.73; H, 4.17; N, 3.82%. NMR (DMSO-d6, 250MHz): 9.05 (s, 1H), 8.05 (dd, 1R, J - 2Hz and 9Hz), 7.55 (m, kR), 7.45 (d, 1H, J = 9Hz), 7.25 (d, 1H) J = 3Hz), 7.15 (m, 1H), 4.65 (m, 2H), 3.8 (s, 3H, 1.45 (t, 3H, J = 6.5Hz). MS: Calcd. for C19H15F2NO4: 359.0969. Found: 359.0963. EXAMPLE 25 6,8-Difluoro-1-ethyl-7-(2-hydroxyphenyl) 1,4-dihydroquinol-4-one 3-carboxylic acid 135 Mg (45% yield) was prepared by the method of Example 12 from 310 mg 6,8-difluoro-l-ethyl-7-(2methoxyphenyl)-1,4-dihydroquinol-4-one 3-carboxylic acid. A cream solid of m.p. > 260 C was recovered. Anal. calcd. for C18H13F2NO4.1/4H2O: C, 61.80; H, 3.71; N, 4.00%. Found: C, 61.54; 3, 3.98; N, 3.91%. NMR (DMSO-d6, 250MHz): 10 (br s, 1H), 9.1 (s, 1H), 8.05 (dd, 1H) J = 2Hz and 9 Hz), 7.35 (m, 2H), 7.0 (m, 2H), 4.65 (m, 2H), 1.45 (t, 3H, J = 6Hz). MS: Calcd. C18H13F2N04: 345.0911. Found: 345.0911. EXAMPLE 26 3-Bromo-4-fluoroaniline A. 10.68 G (95% yield) was prepared by the method of Example 1B from 13 g of 3-bromo-4-fluoronitrobenzene. The product was an oil which was used without further purification. NMR (CDC13, 250MHz): 6.9 (m, 2H), 6.6 (m, 1H). Ethyl 7-bromo-6-fluoro-4-hydroxyquinoline 3-carboxylate B. 8.8 G (55% yield) was ptepared by the method of Example 1C from 10 g 3-bromo-4-fluoroaniline and 11.36 g diethyl ethoxymethylene. A white solid of m.p.) 280 C was recovered. NMR (DMSO-d6/Trifluoroacetic acid-d, 250ME2): 9.35 (s, 1H), 8.6 (d, 1H, J = 6Hz), 8.3 (d, 1H, J = 11Hz), 4.65 (q, 2H, J = 6.5Hz), 1.5 (t, 3H, J s 6.5Hz). MS: Calcd. for Cl2H9FBrNo3: 312.9759. Found: 312.9766. Ethyl 7-bromo-1-ethyl-6-fluoro-1,4-dihydro guinol-4-one 3-carboxylate C. 5.2 G (55% yield) was prepared by the method of Example 1D from 8.6 g ethyl 7-bromo-6-fluoro-4-hydro xyquinoline 3-carboxylate. White solid of m.p. 149150 C. NMR (CDCl3, 250MHz); 8.45 (s, 1H), 8.15 (d, 1H) J = 11Hz), 7.7 (d, 1H, J = 6Hz), 4.4 (q, 2H, J 6.5Hz), 4.2 (q, 2H, J 1 6.5Hz), 1.55 (t, 3H, J ¯ 6.5Hz), 1.4 (t, 3H, J - 6.5Hz). MS: Calcd. for C14H13BrFN03: 341.0062. Found: 341.0023. Ethyl 1-ethyl-6-fluoro-7-(4-methoxyphenyl)-1,4 dihydroquinol-4-one 3-carboxylate D. 422 mg (64% yield) was prepared by the method of Example 13A from 500 mg 4-bromoanisole, 2.67 ml 2M t-butyl lithium, 500 mg anhydrous zinc chloride, 608 mg ethyl 7-bromo-l-ethyl-6-fluoro-1,4-dihydro- quinol-4-one 3-carboxylate, and 300 mg tetrakis (triphenylosphine)palladium. Yellow solid of m.p. 215-218 C. NMR (CDC13, 250MHz): 8.45 (s, 1H), 8.2 (d, 1H, J = 11Hz), 7.55 (dd, 2H, J = 9Hz and 2Hz), 7.45 (d, 1H, J = 6Hz), 7.0 (d, 2H, J = 9Hz), 4.4 (q, 2H, J = 6.5 Hz), 4.3 (q, 2H, J = 6.5 Hz), 3.9 (s, 3H), 1.6 (t, 3H, J = 6.5Hz), 1.45 (t, 3H, J - 6.5Hz). 1-Ethyl-6-fluoro-7-(4-methoxyphenyl)-1,4 dihydroquinol-4-one 3-carboxylic acid (R1=R2=H; Y=ethyl; R3=4-methoxyphenyl) E. 355 Mg (96% yield) was prepared by the method of Example 13B from 400 mg ethyl l-ethyl-6-fluoro-7-(4methoxyphenyl)-1,4-dihydroquinol-4-one 3-carboxylate. White solid of m.p. 279-- 282 C. NMR (DMSO-d6/Trifluoroacetic acid-d, 250MHz): -' 9.4 (s, 1H), 8.4 (d, 1H, J = 11Hz), 8.3 (d, 1H, J = 6Hz), 7.75 (d, 2H, J = 9Hz), 7.2 (d, 2H, J = 9Hz), 5.0 (m, 2H), 4.0 (s, 3H), 1.8 (t, 3H, J = 6.5 Hz). MS: Calcd. for C19H16FN04: 341.1064. Found: 341.1057. Anal.: Calcd. for C19H16FN04: C, 65.14; H, 4.86; N, 4.00%. Found; C, 65.19; H, 4.74; N, 3.91%. EXAMPLE 27 1-Ethyl-6-fluoro-7-(4-hydroxyphenyl)-1,4 dihydroquinol-4-one 3-carboxyl ic acid 276 Mg (96% yield) was prepared by the method of Example 14 from 300 mg 1-ethyl-6-fluoro-7-(4-methoxy- phenyl)-1,4-dihydroquinol-4-one 3-carboxylic acid. Yellow solid of m.p.) 2800C. NMR (DMSO-d6/trifluoroacetic acid-d, 250MHz): 9.0 (s, 13), 8.0 (d, 13, J = 11Hz), 7.85 (d, 1H, J = 6Hz) 7.3 (d, 2H, J = 9Hz), 6.75 (d, 2H, J = 9Hz), 4.55 (m, 2H), 1.4 (t, 3H, J = 6Hz). MS: Calcd. for Cl8H14FNO4: 327.0907. Found 327.0930. Anal.: Calcd. for Cl8H14NO4.1/8H2O: C, 65.60; H, 4.32; N, 4.25%. Found: C, 65.65; H, 4.43; N, 4.10%. EXAMPLE 28 Ethyl 1-ethyl-6-fluoro-7-phenyl-1,4 dihydroquinol-4-one 3-carboxylate 173 Mg t5196 yield) was prepared by the method of Example 1E from 0.72 ml 1.83 M phenyl lithium, 300 mg ethyl 7-bromo-6-fluoro-1,4-dihydroquinol-4-one 3-carboxylate, 192 mg winc chloride and i04 mg tetrakis- (triphenylphosphine) palladium. This sample was identical in every respect with that prepared in Example 4E. MS: Calcd. for C20H18FN03:339.1271. Found: 339.1257. EXAMPLE 29 Ethyl 7-(4-t-butyl-dimethylsilyloxymethylphenyl) 1-ethyl-6-fluoro-1,4-dihydroquinol-4-one 3-carboxylate 301 Mg (31% yield) was prepared by the method of Example 2 from 1.51 g 4-bromobenzyl dimethyl-tbutylsilyl ether, 6.72 ml (2 M) t-butyl lithium, 818 mg zinc chloride, 684 mg ethyl 7-bromo-l-ethyl-6-fiuoro 1,4-dihydroquinol-4-one 3-carboxylate and 231 mg tetrakis (triphenylphosphine)palladium. The sample was identical in every way with that prepared in Example 15B. NMR (CDCl3, 250 MHz): 8.5 (s, 1H), 8.25 (d, 1H), 7.5 (q, 4H), 6.9 (d, 1H), 4.8 (s, 2H), 4.4 (q, 2H), 4.3 (q, 2H), 1.58 (t, 3H, J = 7Hz), 1.42 (t, 3R, J = 7Hz), 0.95 (s, 9R), 0.1 (s, 6H). MS: Calcd. for C22H34FNO4Si:483.2241. Found: 483.2241. EXAMPLE 30 Ethyl 7-(3-t-butyl-dimethylsilyloxymethylphenyl) 1-ethyl-6-fluoro-1,4-dihydroquinol-4-one 3-carboxylate 280 Mg (58% yield) was prepared by the method of Example 2 from 602 mg of 3-bromobenzyl dimethyl-tbutyl-silyl ether, 1.64 ml (1.28 M) t-butyl lithium, 341 mg zinc chloride, 342 mg ethyl 7-bromo-1-ethyl-6- fluoro-1,4-dihydroquinol-4-one 3-carboxylate and 115 mg tetrakis(triphenylphosphine)palladium. The sample was identical in every respect with that prepared in Example 16B. NMR (CDC13, 90MHz): 8.6 (s, 1H), 8.3 (d, 1H), 7.5 (m, 5H), 4.9 (s, 2H), 4.45 (q, 4H), 1.5 (5 line m, 6E), 0.95 (s, 9H), 0.1 (s, 6H). MS: Calcd. for C27H34FNO4Si:483.2241. Found: 483.2195. EXAMPLE 31 Ethyl 7-bromo-6,8-difluoro-1-(2-fluoroethyl)-1,4 dihydroquinol-4-one 3-carboxylate A. By the method of Example 1D, ethyl 7-bromo-6,8difluoro-4-hydroxyquinoline-3-carboxylate (5.0 g, 15 mmol), anhydrous potassium carbonate (4.2 g, 30 mmol), l-fluoro-2-bromo-ethane (25 g, 15 ml, 200 mmol) in dimethylformamide (50 ml) were reacted to give a white solid after recrystallization from 2-propanol (3.3 g, 58% yield), m.p. 185 - 1870C; IR (CHCl3, cm-l): 1732(s), 1695(s), 1461(s); NMR (CDCl3, 250ME2): 8.39 (s, 1H), 8.14 (dd, lH, J = 10, 4 Hz), 4.95-4.85 (m, 2H), 4.78-4.5s (m, 2H),4.40 (q, 2H, J = 7Hz), 1.40 (t, 3R, J = 7 Hz). Anal.: Calcd. for C14HllBrF3N03: C, 44.49, R, 2.93, N, 3.71, Br, 21.14, F, 15.08: Found: C, 44.35, H, 2.98, N, 3.64, Br, 21.50, F, 14.65. Ethyl 6,8-difluoro-7-(4-methoxyphenyl)-1 (2-fluoroethyl)-1,4-dihydroquinol-4-one 3-carboxylate B. By the method of Example 2, ethyl 7-bromo-6,8 difluoro-1-(2-fluoroethyl)-1,4-dihydroquinol-4-One 3-carboxylate (1.0 g, 2.7 mmol), l-bromo-4-methoxy benzene (1.24 g, 0.83 ml, 6.6 mmol), a solution of t-butyl lithium in n-pentane (1.8 M, 7.4 ml, 13.3 mmol), anhydrous zinc chloride (1.1 g, 8.0 mmol) and tetrakis(triphenylphosphine)palladium (306 mg) were reacted to give crude product as a yellow solid. Chromatography on silica gel with ethyl acetate afforded a solid (507 mg, 47% yield); m.p. 193 - 1950C; IR (KBr, cm-1): 1726 (s), 1612 (s) 1575 (m), 1541 (m), 1518 (m); NMR (CDC13, 250 MHz): 8.42 (s, lH), 8.16 (dd, 1H, J = 10, 4 Hz), 7.43 (d, 2H, J = 9 Hz), 7.05 (d, 28, J = 9 Hz), 4.95-4.65 (m, 4H), 4.42 (q, 2H, J o 7 Hz), 3.91 (s, 3H), 1.42 (t, 3H, J = 7 Hz). Anal.: Calcd. for C21H18F3N04.H20: C, 59.57, H, 4.76, N, 3.31. Found: C, 59.83, H, 4.33, N, 3.28. 6,8-Difluoro-7-(4-methoxyphenyl)-1-(2 fluoroethyl)-1,4-dihydroquinol-4-one 3-carboxylic acid C. By the method of Example 13B, ethyl 6, 8-difluoro-7- (4-methoxyphenyl)-1-(2-fluoroethyl)-1,4-dihydroquinol4-one 3-carboxylate (275 mg, 0.7 mmol) was hydrolyzed to gives white solid (191 mg, 75% yield); m.p. > 270 C; IR (KBr, cm-1): 1720 (s), 1621 (s), 1612 (s); NMR (1% DMSO-d6/CF3CO2D, 250 MHz): 8.90 (s, 1H), 7.90 (d, 1H, J = 9 Hz), 7.22 (d, 2H, J = 10 Hz), 6.80 (d, 2H, J = 10 Hz), 4.95 (br. d, 2H, J = 24 Hz), 4.65 (d, 2H, J n 45 Hz), 3.57 (s, 3H). Anal.: Calcd. for C19H14F3N04.0.75 H20: C, 58.39, H, 3.99, N, 3.58. Found: C, 58.12, H, 3.75, N, 3.38. EXAMPLE 32 6,8-Difluoro-7-(4-hydroxyphenyl)-1-(2 fluoroethyl)-1,4-dihydroquinol-4-one 3-carboxylic acid By the method of Example 14, 6,8-difluoro-7-(4methoxyphenyl)-1-(2-fluoroethyl)-1,4-dihydroquinol-4one 3-carboxylictacid (200 mg, 0.53 mmol) and a solution of boron tribromide in methylene chloride (1 M, 5.3 ml, 5.3 mmol) were reacted to give crude product as a yellow solid. Trituration with boiling water affor ded 2 white solid (131 mg, 66% yield); m.p. > > 280 C; IR (KBr, cm-l): 1724 (s), 1610 (s), 1589 Is), 1567 (m); NMR (1% DMSO-d6/CF3CO2D, 250 MHz): 9.35 (s, 1H), 8.34 (d, 1H, J t 10 Hz), 7.55 (d, 2E, J = 9 Hz), 7.20 (d, 2H, J = 9 Hz), 5.38 (d, 2H, J = 24 Hz), 5.00 (d, 2H, J = 45 Hz); MS: calcd. for C18R12F3N04: 363.0719. Found: 363.0709 Anal.: Calcd. for C18H12F3N04.H20: C, 56.70, H, 3.70, N, 3.67. Found: C, 56.99, H, 3.45, N, 3.67. EXAMPLE 33 Ethyl 7-bromo-6,8-difluoro-l-ethyl-1,4- dihydroquinol-4 -one 3-carboxylate A. By the method of Example 1D, ethyl 7-bromo-6,8- difluoro-4-hydroxyquinolinone-3-carboxylate (5.0 g, 15 mmol), anhydrous potassium carbonate (4.16 g, 30 mmol) and iodomethane (6.4 g, 2.8 ml, 45 mmol) in dimethylformamide (50 ml) were reacted to give a white solid, after recrystallization from 2-propanol (3.4 g, 66% yield); m.p. 174 - 175 C; IR (CHC13, cm-l); 1732 (S), 1693 (s), 1642 (s), 1611 (s); NMR (CDC13, 250 MHz): 8.40 (s, 1H), 8.00 (dd, 1H, J = 10, 4 Hz), 4.35 (q, 2H, J = = 7 Hz), 4.08 (d, 3E, J = 8 Hz), 1.58 (t, 3H, J = 7 Hz). Anal.: Calcd. for Cl3H10BrF2NO3: C, 45.13, H, 2.92, N, 4.05, Br, 23.10, F, 10.98. Found: Ct 45.05, H, 2.70, N, 4.01, Br, 22.83, F, 10.52. Ethyl 6,8-difluoro-7-(4-methoxyphenyl)-1 methyl-1,4-dihydroquinol-4-one 3-carboxylate B. By the method of Example 2, ethyl 7-bromo-6,8 difluoro-l-methyl-1,4-dihydroquinol-4-one-3-carboxyloop (1.0 g, 2.9 mmol), l-bromo-4-methoxybenzene (1,35 g, 0.91 ml, 7.3 mmol), a solution of t-butyl lithium in pentane (1.8 M, 8.1 ml, 14.6 mmol) and anhydrous zinc chloride (1.31 g, 9.6 mmol) and tetrakis(triphenylphosphine) palladium (306 mg) were reacted to yield crude product as a yellow solid.. Column chromatography with ethyl acetate on silica gel afforded a solid (624 mg, 57% yield); m.p. 176 - 1780C; IR (KBr, cm-l): 1733 (m), 1684 (s), 1639 (s), 1617 (s), 1540 (m); NMR (CDCl3, 250 MHz): 8.38 (s, 1H), 8.08 (dd, 1H, J = 10, 4 Hz), 7.42 (d, 2H, J 2 B Hz), 7.05 (d, 2H, J = 8 Hz), 4.41 (q, 2H, J = 7 Hz), 4.12 (d, 3H, J = 8 Hz), 3.90 (s, 3H), 1.42 (t, 3H, J = 7 Hz); MS (m/e): 373 (parent), 201 (base). Anal.: Calcd. for C20H13F2NO4.0.5H20: C, 62.83, H, 4.74, N, 3.66. Found: C, 63.22, H, 4.77, N, 3.42. 6,8-Difluoro-7-(methoxyphenyl)-1-methyl-1,4 dihydroquinol-4 -one 3-carboxylic acid C. By the method of Example 13B, ethyl 6,8-difluoro 7-(4-methoxyphenyl)-1,4-dihydroquinol-4-one 3-carboxylate (446 mg, 1.2 mmol), was hydrolized to give a white solid (332 mg, 80% yield); m. p. > 280 C; IR (KBr, cm-1): 1718 (s), 1612 (s), 1567 (s), 1539 (s); NMR (CF3C02D, 250 MHz): 9.30 (s, 1H), 8.25 (d, 1H, J = 10 Hz), 7.65 (d, 2H, J = 10 Hz), 7.22 (d, 2R, J = 10 Hz), 4.70 (d, 3H, J = 10 Hz), 3.96 (s, 3H); MS: Calcd. for C18H13F2NO4: 345.0812. Found: 345.0821. Anal.: Calcd. for C18H13F2N04: 62.61, R, 3.79, N, 4.06. Found: C, 62.43, H, 3.81, N, 3.95. EXAMPLE 34 6, 8-Difluoro-7-( 4-hydroxyphenyl )-l-methyl-l, 4 dihydroquinol-4-one 3-carboxylic acid - By the method of Example 14, 6,8-difluoro-7-(4methoxyphenyl ) -l-methyl-1, 4-dihydroquinol-4-one 3-carboxylic acid (202 mg, 0.6 mmol) and a solution of boron tribromide in methylene chloride (I M, 5.9 ml, 5.9 mmol) were reacted to give crude product as a yellow solid. Trituration with hot water afforded a white solid (126 mg, 65% yield); m. p. > 270 C; NMR (CF3C02D, 250 MHz): 9.34 (s, 1H), 8.30 (d, 1H, J = 10 Hz), 7.58 (d, 2H, J = 10 Hz), 7.20 (d, 2H, J = 10 Hz), 4.73 (d, 3H, J = 10 Hz); MS: calcd. for Cl6H11F2NO2 (parent - C02): 287.0758. Found: 287.0751. Anal.: Calcd. for Cl7H11F2NO4.o.25H20: C, 60.81, H, 3.45, N, 4.17. Found: C, 60.46, H, 3.33, N, 4.05. EXAMPLE 35 Ethyl 7-bromo-6,8-difluoro-1-allyl-1,4 dihydroquinol-4-one 3-carboxylate By the method of Example 1D, ethyl-7-bromo-6,8- difluoro-4-hydroxyquinoline 3-carboxylate (5.0 g, 15 mmol), anhydrous potassium carbonate (4.16 g, 30 mmol) and allyl bromide (5.4 g, 4 ml, 45 mmol) in dimethylformamide (50 ml) were reacted to give a white solid, after recrystallization from 2-propanol (4.2g, 75% yield); m.p. 141 - 143 C; IR (CHC13, cm-l): 1732 (s), 1694 (s), 1642 (s), 1610 (s), 1546 (m); NMR (CDC13, 250 MHz): 8.40 (s, 1H), 8.12 (dd, lH, J = 10, 4 Hz); 6.15-6.00 (m, 1H), 5.35 (d, 1H, J = 10 Hz), 5.18 (d, 1H, J = 20 Hz), 5.00-4.86 (m, 2R), 4.40 (q, 2H, 3 = 7 Hz), 1.40 (t, 3H, J = 7 Hz). Anal.: Calcd. for C15H12BrF2N03: C, 48.43, H, 3.25, N, 3.77, Br, 21.48, F, 10.21. Found: C, 48.13, H, 3.28, N, 3.66, Br, 21.15, F, 10.29. EXAMPLE 36 Ethyl 7-bromo-6,8-difluoro-1-benzyl-1,4 dihydroquinol-4-one 3-carboxylate By the method of Exanple 1D, ethyl 7-bromo-6,8difluoro-4-hydroxyquinoline 3-carboxylate (5.0 g, 15 mmol), anhydrous potassium carbonate (4.2 g, 30 mmol) and benzyl bromide (7.7 g, 5.4 ml, 45 mmol) in dimethylformamide (50 ml) were reacted to give a white solid after recrystallization from 2-propanol (4.4 g, 70% yield); m.p. 184 - 1860C; IR (CHCl3, cm-l): 1732 (s), 1695 (s), 1643 (s), 1610 (s), 1548 (m); NMR (CDC13, 250 MHz): 8.50 (s, 1H), 8.10 (d, 1H, J s 10 Hz) 7.45-7.25 (m, 3E), 7.17-7.05 (m, 2H), 5.55 (d, 2H, J = 4 Hz), 4.40 (q, 2H, J - 7 Hz), 1.40 (t, 3H, J 7 Hz). Anal.: Calcd. for Cl9H14BrF2NO3: C, 54.05, H, 3.34, N, 3.32, Br, 18.90, F, 9.00. Found: C, 53.59, H, 3.30, N, 3.24, Br, 18.80, F, 9.10. EXAMPLE 37 Ethyl 7-bromo-6,8-difluoro-l-propyl-1,4 dihydroquinol-4-one 3-carboxylate A. By the method of Example 1D, ethyl 7-bromo-6,8difluoro-4-hydroxyquinoline 3-carboxylate (5.0 g, 15 mmol), anhydrous potassium carbonate (4.16 g, 30 mmol) and l-bromopropane (11 g, 8.2 ml, 90 mmol) in dimethylformamide (50 ml) were reacted to give a white solid, after recrystallization from 2-propanol (2.7 g, 48% yield); m. p. 139 - 140 C; IR (CHC13, cm-1): 1731 (s), 1692 (s), 1641 (s), 1610 (s); NMR (CDC13, 250 MHz); 8.40 (s, 1H), 8.15 (dd, 1E, J = 10, 4 Hz), 4.42 (q 2H, J = 7 Hz), 4.35-4.25 (m, 2H), 1.94 (sextet, ZH, J = 7 Hz), 1.42 (t, 3H, J = 7 Hz). Anal.: Calcd. for Cl5H14BrF2NO3: C,48.17, H, 3.77, N, 3.75, Br, 21.37, F, 10.16. Found: C, 47.86, , 3.73, N, 3.84, Br, 21.10, F, 10.35. Ethyl 6,8-difluoro-7-(4-methoxyphenyl)-1-propyl 1,4-dihydroquinol-4-one 3-carboxylate B. By the method af Example 2, ethyl 7-bromo-6,8difluoro-1-propyl-1,4-dihydroquinol-4-one 3-carboxylate (1.0 g, 2.7 mmol), 1-bromo-4-methoxybenzene (1.26 g, 0.84 ml, 6.75 mmol), anhydrous zinc chloride (1.1 g, 8.1 mmol), a solution of t-butyl lithium in pentane (1.8 M, 7.5 ml, 13.5 mmol) and tetrakis(triphenylphosphine) palladium (320 mg ) were reacted to give crude product as a yellow solid. Chromatography with ethyl acetate on silica gel afforded a pale yellow solid (360 mg, 73% yield); m. p. 126 - 128 C; IR (KBr, cm-1): 1734 (s), 1612 (s), 1574 (m); NMR (CDC13, 250 MHz): 8.45 (s, 1H), 8.15 (dd, 1H, J = 10, 3Hz), 7.42 (d, 2H, J t 8 Hz), 7.05 (d, 2R, J 8 Hz), 4.44 (q, 2H, J = 7 Hz, 3.92 (s, 3H), 3.35-3.25 (m, 2H), 2.00-1.85 (m, 2H), 1.45 (t, 3H, J = 7 Hz), 1.00 (t, 3H, J = 7 Hz). Anal.: Calcd. for C22G21F2NO4. 0.25H20: C, 65.10, H, 5.34, N, 3.45. Found: C, 65.22, H, 5.24, N, 3.38. 6,8-Difluoro-7-(4-methoxyphenyl)-1-propyl-1,4 dihydroquinol-4-one 3-carboxylic acid C. By the method of Example 13B, ethyl 6,8-difluoro7-(4-methoxyphenyl)-1-propyl-1,4-dihydroquinol-4-.one 3-carboxylate (245 mg, 0.6 mmol) was hydrolyzed to give a white solid (154 mg, 68% yield); m.p. 272 - 2740C; IR (KBr, cm-1): 1722 (s), 1612 (s); NMR (1% DMSO-d6/ CF3CO2D,, 250 MHz): 9.34 (s, 1H), 8.30 (d, 1H, J = 8 Hz), 7.62 (d; 2H, J = 8 Hz), 7.22 (d, 2H, J = 8 Hz), 5.104.88 (m, 2H), 3.96 (s, 3H), 2.25-2.10 (m, 2H), 1.12 (t, 3H, J = 7 Hz) MS: Calcd. for C20H17F2N04: 373.1126. Found: 373.1146. Anal.: Calcd. for C20H17F2N04: C, 64.34, H, 4.59, N, 3.75. Found: C, 63.91, H, 4.49, N, 3.67. EXAMPLE 38 6,8-Difluoro-7-(4-hydroxyphenyl)-1-propyl-1,4 dihydroquinol-4-one 3-carboxylic acid By the method of Example 14, 6,8-difluoro-7-{4methoxyphenyl)-1-propyl-1,4-dihydroquinol-4-one 3-carboxylic acid (103 mg, 0.28 mmol) and a solution of boron tribromide in methylene chloride (1 M, 2.8 ml, 2.8 mmol) were reacted to give crude product as a yellow solid. Trituration with boiling water and filtration afforded a white solid (98 mg, 98% yield); m.p. 262 - 2640C; IR (KBr, cm-l): 1721 (s), 1614 (m), 1561 (m); NMR (18 DMSO-d6SCF3C02D, 250 MHz): 9.35 (s, 1H), 8.30 (d, 1H, J = 8 Hz), 7.62 (d, 2H, J = 8 Hz), 7.20 (d, 2R, J = 8 Hz), 5.10-4.95 (m, 2B), 3.98 (s, 3E), 2.20-2.10 (m, 2H), 1.60-1.40 (m, 2H), 1.05 (t, 3H, J = 7 Hz). MS: Calcd. for C19H15F2N04: 359.0980. Found: 359.0969. EXAMPLE 39 Ethyl 7-bromo-6,8-difluoro-1-butyl-1,4 dihydroquinol-4-one 3-carboxylate A. By the method of Example 1D, ethyl 7-bromo-6,8- difluoro-4-hydroxyquinoline 3-carboxylate (5.0 g, 15 mmol), anhydrous potassium carbonate (4.2 g, 30 mmol) and l-bromobutane (18.5 g, 14.4 ml, 135 mmol) in dimethylformamide were reacted to give a white solid, after recrystallization from 2-propanol (3.1 g, 53% yield); m. p. 140 - 141 C; IR (CHC13, cm-1): 1731 (s), 1692 (s), 1641 (s), 1610 (s), 1547 (m), 1480 (s); NMR (CDCl3, 250 MHz): 8.40 (5, 1H), 8.15 (dd, 1H, J X 10, 4 Hz), 4.42 (q, 2H, J - 7 Hz). 4.40-4.25 (m, 2H), 1.95-1.85 (m, 2z), 1.65-1.40 (m, 2H), 1.41 (t, 3H, J 7 Hz), 1.00 (t, 3H, J = 7 Hz). Anal.: Calcd. for Cl6H16BrF2NO3: C, 49.53, H, 4.16, N, 3.61, Br, 20.60, F, 9.79. Found: C, 49.65, H, 4.12, N, 3.56, Br, 20.59, F, 10.21. Ethyl 6,8-difluoro-7-(4-methoxyphenyl)-1 butyl-1,4-dihydroquinol-4-one 3-carboxylate B. By the method of Example 2, ethyl 7-bromo-6,8difluoro-1-butyl-1,4-dihydroquinol-4-one 3-carboxylate (1 g, 2.6 mmol), l-bromo-4-methoxybenzene (1.22 g, 0.82 ml, 6.6 mmol),. anhydrous zinc chloride (1.1 g, 8.1 mmol), a solution of t-butyl lithium in pentane (1.8 M, 7.3 ml, 13.1 mmol) and tetrakis(triphenyl phosphine)palladium (300 mg) were reacted to give crude product as a yellow solid, which was used without further purification. 6,8-Difluoro-7-(4-methoxyphenyl)-1-butyl-1,4 dihydroquinol-4-one 3-carboxylic acid C. By the method of Example 13B, ethyl 6,8-difluoro7-(methoxyphenyl)-1-butyl-1,4-dihydroquinol-4-one 3carboxylate was hydrolyzed to give a white solid (134 mg, 13% yield); m.p. 248 - 2490C; IR (KBr, cm-1): 1721 (s), 1614 (m), 1561 (m), 1538 (m); NMR (1% DMSO-d6/CF3CO2D, 250 MHz): 9.35 (s, 1H), 8.30 (d, 1R, J = 8 Hz), 7.62 (d, 2H, J = 8 Hz) , 7.20 (d, 2H, J = 8 Hz), 5.10-4.95 (m, 2H), 3.98 (s, 3H), 2.20-2.10 (m, 2H), 1.60-1.40 (m, 2E), 1.05 (t, 3H, J = 7 Hz); MS: 387 (parent), 343 (base). Anal.: Calcd. for C21H19'F2N04. 0.5 E20: C, 63.63, H, 5.09, N, 3.53. Found: C, 63.73, H, 4.79, N, 3.46. EXAMPLE 40 6,8-Difluoro-7-(4-hydroxyphenyl)-1-butyl-1,4 dihydroquinol-4-one 3-carboxylic acid By the method of Example 14, 6,8-difluoro-7-(4methoxyphenyl)-1-butyl-1,4-dihydroquinol-4-one 3-carboxylic acid (91 mg, 0.24 mmol) and a solution of boron tribromide (1, M, 2.4 ml, 2.4 mmol) were reacted to give crude product as a yellow solid. Trituration with boiling water, filtration and drying in vacuo afforded a white solid (40 mg, 45% yield); NMR (5% DMSO-d6/CF3CO2D, 250 MRz): 9.46 (s, 1H), 8.35 (d, 1H, J = 10 Hz), 7.56 (d, 2H, J = 10 Hz), 7.20 (d, 2H, J = 10 Hz), 5.10-4.95 (m, 1H), 2.25-2.05 (m, 2H), 1.75-1.55 (m, 2H), 1.10 (t, 3H, J = 7 Hz); MS: calcd. for C20H17F2N04: 373.1126. Found: 373.1082. Anal.: Calcd. for C20H17F2N04. 0.75 H20: C, 62.09, H, 4.82, N, 3.62. Found: C, 62.15, H, 4.82, N, 3.85. EXAMPLE 41 Ethyl 6,8-difluoro-7-(4-chlorosulfonylphenyl) 1-ethyl-1,4-dihydroquinol-4-one 3-carboxylate A. By the method of Example 10A, ethyl 6,8-difluoro7-phenyl-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylate (0.55 g, 1.53 mmol) and chlorosulfonic acid (6 ml) were reacted in methylene chloride (10 ml) to give a yellow oil (0.7 g), which was used without further purification. Ethyl 6,8-difluoro-7-(4-aminosulfonylphenyl) 1-ethyl-1,4-dihydroquinol-4-one 3-carboxylate B. Ethyl 6,8-difluoro-7-(4-chlorosulfonylphenyl)-1ethyl-1,4-dihydroquinol-one 3-carboxylate (0.7 g) was dissolved in dry tetrahydrofuran (10 ml) and the resulting solution was cooled to -78 C. Ammonia (5 ml) was condensed into the reaction mixture with stirring, The reaction mixture was warmed to room temperature and stirred for 16 hours. Solvent was removed in vacuo and the crude product was triturated with water, then ether. Drying in vacuo afforded a pale yellow solid (0.6 g, 90% yield); m. p. > 250 C; NMR (3% DMSO-d6/ CF3CO2D, 250 MHz): 9.38 (s, 1H), 8.40 (d, 1H, J - 8 Hz), 8.20 (d, 2H, J = 8 Hz), 7.95-7.85 (m, 2H), 7.72 (d, 2H, J = 8 Hz), 5.20-5.05 (m, 2H), 4.72 (g, 4H, J - 7 Hz), 1.80 (t, 3H, J = 7Rz), 1.55 (t, 3H, J = 7 Hz) MS: Calcd. C20H18F2N205S: 436.0909. Found: 436.0912. 6,8-Difluoro-7-(4-aminosulfonylphenyl)-1-ethyl 1,4-dihydroquinol-4-one 2-carboxylic acid C. By the method of Example 10C, ethyl 6,8-difluoro7-(4-aminosulfonylphenyl)-1-ethyl-1,4-dihydroquinol-4one-3-carboxylate (0.32 g, 0.73 mmol) and 2 IN sodium hydroxide solution were reacted in ethanol (4 ml) to give a white solid (0.25 g, 84% yield); m.p.) 250C; NMR (1% DMSO-d6/CF3CO2D, 250 MHz): 9.45 (s, 1H), 8.40 (d, 1H, J = 8 Hz), 8.24 (d, 2H, J = 8 Hz), 8.00-7.85 (m, 2E), 7.85 (m, 2H), 5.25-5.00 (m, 2H), 1.82 (t, 3H, J = 7 Hz). MS: Calcd. for C18H14F2N205S: 408.0580. Found: 408.0560. EXAMPLE 42 In addition, the following compounds were prepared: EMI82.1 TABLE I R1 R2 R4 Melting point in C. C2H5 F 3-SCH3 157-8 C2H5 F 3-CF3 133-4 C2H5 F 3-F 154-5 C2H5 F 3-CH3 172-3 C2H5 F 3-F,4-CH3 183-4 C2H5 F 3-CH3,4-OCH3 199-200 H F 3-SCH3 250-2 H F 3-CF3 280-1 H F 3-F 297-8 H F 3-CH3 289-90 C2H5 F 3-S(O)CH3 165-6 H F 3-(s(O)C)S2 277-8 C2H5 F 3-SO2CH3 215-6 H F 3-SO2CH3 242-3 H F 3-CH2OH,4-OH 227-30 H F 3-CH2N3 230-2 H F 3-F, 4-OH 263-5 H F 3-CH3,4-OH 263-5 TABLE I (Ctd.) R1 R2 R4 Melting point in C. H F 3-CH3,4-OCH3 282-4 H F 3-F,4-OCH3 280 C2H5 F 3,4-O-CH2-O- - (1) H F 3,4-O-CH2-O- > 260 C2H5 F 4-C=NH 134-6 OC2HS H F 4-CO2H > 260 C2H5 F 2,4-di-OCH3 (2) H F 2,4-di-OCH3 > 260 C2H5 F 3,5-di-OCH3 - (3) H F 3,5-di-OCH3 > 260 H F 2,4-di-OH > 260 H F 3,5-di-OH > 260 C2H5 H 3-F,4-OCH3 - (4) H H 3-F,4-OCH3 > 260 H H 3-F,4-OH > 260 C H H 3-Cl,4-OCH3 227-9 H H 3-Cl,4-OCH3 > 260 H H 3-Cl,4-OH > 260 C2H5 H 3,5-di-CH3,4-OCH3 228-30 H H 3,5-di-CH3,4-OH 308-9 (1) NMR (CDCl3, 60 MHz): 8.4 (s, 1H), 8.01 (dd, 1H, J = 2 Hz and 9 Hz), 6.95 (s, 3H), 6.05 (s, 2H), 4.4 (g, 4H), 1.45 (two overlapping triplets, 6H). (2) NMR (CDCl3, 60 MHz): 8.4 (s, lR), 8.05 (d, 1H), 7.2 (m, 2H), 6.6 (s, 1H), 4.4 (m, 4H), 3.85 (s, 3H), 3.8 (s, 3H), 1.45 (m, 6H). (3) NMR (CDCl3, 60 MHz): 8.39 (s, 1H), 8.1 (dd, 1H), 6.58 (5, 3H), 4.4 (q, 4H), 3.9 (s, 6H), 1.5 (m, 6H). (4) NMR (CDC13, 250 MRz): 8.55 (s, 1E), 8.27 (d, 1H, J - 13.5 Hz), 7.5 (m, 4H), 4.45 (q, 2H), 4.3 (q, 2E), 3.95 (s, 3H), 1.6 (t, 3H), 1.42 (t, 3H). EXAMPLE 43 2,4-Difluoro-3-bromo-l-nitrobenzene A. A solution of 1,3-difluoro-2-bromobenzene (23.5 g, 112 mmol) in concentrated sulfuric acid (48 ml) was stirred vigorously at ambient temperature. Concentrated nitric acid (70%, 8 ml) was added dropwise such that the internal temperature of the reaction mixture did not exceed 55 C. The reaction mixture was then stirred from 15 minutes and poured onto ice (300 ml). The aqueous mixture was extracted three times with methylene chloride. The combined organic layers were washed three times with a saturated sodium bicarbonate solution, dried over magnesium sulfate and filtered. Solvent was removed in vacuo to give a yellow solid. Recrystallization from isopropyl ether afforded a white solid 128.2 g, 97% yield): m.p. 50-51 C. NMR (CDCl3, 60 MHz): 8.4-7.9 (m, 1H), 7.4-7.0 (m, 1H). Anal.: Calcd. for C6H2BrF2NO2: C, 30.28, H, 0.85, N, 5,89, Br, 33.57, F, 15.96. Found: C, 30.34, X, 0.98, N, 5.81, Br, 33.81, F, 16.04. 3-Bromo-4-fluoro-2-hydroxy-1-nitrobenzene B. A solution of 3-bromo-2,4-difluoro-l-nitrobenzene (10.5 g, 44 mmol) in dimethyl sulfoxide (85 ml) was stirred at ambient temperature. A solution of potassium hydroxide (14.1 g, 251 mmol) in water (21 x was added dropwise over 15 minutes. The black reaction mixture was stirred at ambient temperature for 16 hours. The reaction mixture was then poured onto water (200 ml) and three ether extractions (100 ml) were performed. The aqueous layer was acidified with concentrated hydrochloric acid and extracted three tires with ether (100 ml). The combined organic layers were dried over magnesium sulfate and filtered. Solvent was removed in vacuo to give a yellow solid (9.7 g, 93% yield). Recrystallization from isopropyl ether afforded an analytical sample: m.p. 65-66 C. NMR (CDC13, 60 MHz): 8.1 (dd, 1H, J= 10, 5 Hz), 6.8 (dd, 1H, J=l0, 8 Hz) Anal.: Calcd. for C6H3BrFNO3: C, 30.54, H, 1.30, N, 5.94, Br, 33.86, F, 8.05. Found: C, 30.52, H, 1.27, N, 5.70, Br, 33.56, F, 7.96. 1-(2-Bromo-3-fluoro-6-nitrophenoxy)-propan-2-one C. Chloroacetone (3.8 g, 3.3 ml, 41 irmol) was added dropwise to a solution of 3-bromo-4-fluoro-2-hydroxy l-nitrobenzene (4.3 g, 18.2 mmol) in acetone (54 ml) with stirring at ambient temperature. Potassium carbonate (5.8 g, 42 mmol) and potassium iodide (6.0 g, 36. 4 mmol), were added and the reaction mixture was heated to reflux'temperature for 2 hours. The reaction mixture was then cooled to room temperature, poured onto water (100 ml), and extracted three times with ethyl acetate (150 ml). The combined organic layers were dried over magnesium sulfate, treated with decolorizing charcoal and filtered through diatomaceous earth. Solvent was removed in vacuo to afford a dark brown oil. Chromatography on silica gel with ethyl acetatehexanes (1:1) afforded, after removal of solvent in vacuo, a dark brown liquid (Rf= 0.67, 3.5 g, 66% yield): NMR(CDC13, 60 MHz): 8.1 (dd, 1H, J = 10, 6 Hz), 7.4 (dd, 1H, J= 10, 8 Hz), 4.6 (s, 2R), 2.3 (s, 3H). 8-Bromo-7-fluoro-3-methyl-2,3-dihydro 1,4-benzoxazine D. Raney nickel (0.5 g) in absolute ethanol (10 ml) was added to a solution of l-(2-bromo-4-fluoro6-nitrophenoxy)-propan-2-one (2,1 9, 7.2 mmol) in absolute ethanol (200 ml). The reaction mixture was then shaken in a Parr apparatus under a hydrogen atmosphere (15 psi) for 1 hour. The reaction mixture was then filtered through diatomaceous earth. Solvent was removed in vacuo to afford a dark brown oil (1.5 g, 85% yield): NMR (CDCl3, 60 MHz): 6.7-6.5 (m, 2H), 4.5-3.7 (m, 3R), 1.3 (d, 3H, J= 7 Hz). Anal.: Calcd. for C9H9BrFNO: C, 43.93, H, 3.69, N, 5.69; Found C, 43.96, H, 3.89, N, 5.14. Ethyl l0-bromo-9-fluoro-3-methyl-7-axo-2,3- dihydro-(7H)-pyrido-(1,2,3-de-1,4 benzoxazine-ó-carboxylate E. 8-Bromo-7-fluoro-3-methyl-2,3-dihydro-1,4benzoxazine (3 g, 12.2 mmol) and diethyl ethoxy methylenemalonate (2.8 g, 2.6 ml, 12.9 mmol) were heated at 1400C. under a nitrogen atmosphere for 1 hour, then under reduced pressure (5 psi) for 0.5 hour. The crude product, diethyl 2-(8-bromo-7- fluoro-3-methyl-2,3-dihydro-1,4-benzoxazinyl)methylenepropane-1,3-dioate, was used without further purification. The above product was stirred with polyphosphoric ester (10 g) at 140eC under a nitrogen atmosphere for 1 hour. The reaction mixture was then poured onto water (200 ml). The aqueous mix was made basic (pH = 10 by test paper) with a saturated sodium hydroxide solution and extracted three times with chloroform (200 ml). The combined organic layers were dried over magnesium sulfate, treated with decolorizing charcoal and filtered through diatomaceous earth. Solvent was removed in vacuo to give a solid. The solid was suspended in a saturated sodium bicarbonate solution (100. ml) and stirred for 30 minutes. The suspension was extracted three times with chloroform and the combined organic layers were dried over magnesium sulfate. Solvent was removed in vacuo to give a solid. Trituration with ether, filtration and drying in vacuo afforded z white solid (2.4 g, 53% yield); m. p. > 2500C. NMR (CDC13, 250 MRz): 8.35 (s, 1R), 7.75 (d, 1H, J= 8Hz), 4.60-4.30 (m, 3H), 4.48 (q, 2H, J = 7 Hz), 1.60 (d, 3H, J= 7 Hz), 1.40 (t, 3H, J= 7 Hz). Anal.: Calcd. for Cl5'dl3BrFNO4: C, 48.67, H, 3.54, N, 3.78, Br, 21.59, F, 5.13. Found: C, 48.44, H, 3.56, N, 3.66, Br, 21.60, F, 5.25. 10-Bromo-9-fluoro-3-methyl-7-oxo-2,3-dihydro (7H)-pyrido-(1,2,3-de)-1,4 benzoxazine-6-carboxylic acid F. A mixture of ethyl l0-bromo-9-flucro-3-ethyl- 7-oxo-2,3-dihydro-(7H)-pirydo-(1,2,3-de)-1,4 benzoxazine-6-carboxylate (0.2 g, 0.54 mmol) and a 3N hydrochloric acid solution (15 ml) were heated at 1000C. with stirring for 17 hours. The reaction mixture was diluted twofold with water and filtered. The white solid1 which was collected, was washed with water, trituratcd with acetone, and filtered. Drying in vacuo afforded z white powder (142 mg, 77% yield): m.p. 250 C. NMR (5% DMSO-d6/CF3C02D, 250 MHz): 9.12 (s, 1R), 7.80 (d, 1H, J= 8Hz), 5.10-5.00 (m, 1 R), 4.80-4.70 (m, 1H), 4.60-4.50 (m, 1H), 1.52 (d,3H, J = 7 Hz). Anal. Calcd. for Cl3H9BrFNO4: C, 45.64, X, 2.65, N, 4.09; Found: C, 45.70, H, 2.64, N, 3.90. Ethyl 9-fluoro-10-phenyl-3-methyl-7-oxo-2,3 dihydro-(7H)-pyrido-(1,2,3-de)-1,4 benzoxazine- 6 -carboxyl ate G. A solution of phenyl lithium (2.7M) in etherbenzene [(3:7), 1.5 ml, 4 mmol] was added to dry tetrahydrofuran (10 ml) and the resulting solution was cooled to -780C with stirring under a nitrogen atmosphere. A solution of freshly fused zinc chloride (0.54 g, 4 mmol) in dry tetrahydrofuran (10 ml) was added dropwise over 5 minutes. The clear, colorless solution was warmed to -300C over 20 minutes. Ethyl 9-fluoro-10-bromo-3-methyl-7-oxo-2,3-dihydro-(7H) pyrido-(l,Z,3-de)-1,4-benzoxazine-6-carboxylate (1.0 g, 2.7 mmol) was added in one portion; then dichlorobis(triphenylphosphine) nickel (0.13 g, 0.2 mmol) was added in one portion. The reaction mixture was gradually warmed to ambient temperature and stirred for 24 hours. The dark brown mixture was poured onto a 1N hydrochloric acid solution (100 ml) and the aqueous mix was stirred for 15 minutes. Three extractions with chloroform (50 ml), drying the combined organic layers over magnesium sulfate, treatment with dccolorizing charcoal and filtration through diatomaceous earth gave a yellow solution. Removal of solvent in vacuo afforded a bright yellow solid. Trituration with ether, filtration and drying in vacuo gave a pale yellow solid (0.67 g, 46% yield): m.p. 270-2720C. NMR (CDC13, 250 MHz): 8.42 (s, 1H), 7.85 (d, 1H, J- 10 Hz), 7.55-7.40 (m, 5H), 4.42 (q, 2H, J= 7Hz), 4.50-4.35 (m, 3E), 1.62 (d, 3H, J- 8Hz), 1.45 (t, 3H, J-7 Hz). MS: Calcd for C21H18FNO4: 367.1223. Found: 367.1179. 9-fluoro-10-phenyl-3-methyl-7-oxo-(7H) 2,3-dihydro-(1,2,3-de)-1,4-benzoxazine 6 carboxylic acid (R1 = H, R3 = phenyl and R2 and Y are taken together forming -O-CH2-CH2-) H. Ethyl 9-fluoro-10-phenyl-3-methyl-7-oxo-(7H)2,3-dihydro-(1,2,3-de)-1,4-bennzoxazine-6-carboxylate (420 mg, 1,1 mmol) was suspended in a 1N hydrochloric acid solution (10 ml) and ethanol (10 ml). The suspension was heated at 900C with stirring. The suspension was cooled to ambient temperature and filtered. The collected solid was washed with water, then with methanol. Drying in vacuo gave a pale yellow solid (0.3 g, 80% yield): m.p. 250 C. NMR (1% DMSO-d6/CF3CO2D, 250 MHz): 8.92 (s, 1H), 7.64 (d, 1H, J= 10 Hz), 7.30-7.10 (m, 5H), 4.85 4.70 (m, 1H), 4.35-4.1S (m, 2 H), 1.42 (d, 3E, 7= 8 Hz). MS: Calcd for Cl9H14FN04: 339.0907 Found: 339.0911. EXAMPLE 44 Ethyl 9-fluoro-10-4-chlorosulfonylphenyl) 3-methyl-7-oxo-2,3-dihydro-(7H)-pyrido-tl,2,3- de)-1,4-benzoxazine-6-carboxylate A. A suspension of ethyl 9-fluoro-10-phenyl-3- methyl-7-oxo-2,3-dihydro-(7E)-pyrido-ll,2,3-dA)- l,4-benzoxazine-6-carboxylate (0.4 g, 1.2 mmol) in dichloromethane (15 ml) was cooled to 0 C with. stirring. Chlorosulfonic acid (5 ml) was added dropwise over 5 minutes. The dark solution was stirred at 0 C for 15 minutes, then it was warmed gradually to room temperature over 1.5 hour. The reaction mixture was poured onto ice water with stirring. Three extractions with chloroform, drying the combined organic layers over magnesium sulfate, filtration and removal of solvent in vacuo gave a yellow oil (0.5 g) which was used without further purification. Ethyl 9-fluoro-10-(4-aminosulfonylphenyl) 3-methyl-7-oxo-2,3-dihydro-(7H)-pyrido (1,2,3-de)-1,4-benzoxazine--carboxylate B. Ethyl 9-fluoro-l0-(4-chlorosulfonylphenyf)- 3-methyl-7-oxo-2,3-dihydro-(7H)-pyrido-(1,2,3-de) 1,4-benzoxazine-6-carboxylate (0.5 g) was dissolved in dry tetrahydrofuran (80 ml) and the resulting solution was cooled to -780C with stirring Ammonia (5 ml) was condensed into the reaction mixture and the yellow suspension was warmed gradually to ambient temperature over 16 hours. Solvent was removed in vacuo and the residue was triturated with water and filtered. Drying in vacuo afforded a solid 10.3 g, 56% yield): m. p. > 250 C. NMR (DMSO-d6, 250 MHz): 8.74 (s, 1H), 7.96 (d, 2H, J = 10 Hz), , 7.74 (d, 2 H, J = 10 Hz), 7.60 (d, 1H, J = 10 Hz), 7.50 (s, 2H), 4.904.75 (m, 1H), 4.55-4.45 (m, 2R), 4.25 (q, 2E, J = 7 Hz), 1.45 (d, 3H, J = 7 Hz), 1.30 (t, 3H, J X 7 Hz). Anal.: Calcd, for C21H19FN206S: C, 56.50, H, 4.29, N, 6.27. Found: C, 56.13, H, 4.52, N, 6.18. 9-Fluoro-TO-(4-aminosulfonylphenyl)-3- methyl-7-oxo-2,3-dihydro-(7H)-pyrido-(1,2,3 de)-1,4-benzoxazine-6-carboxylic acid C. A mixture of ethyl 9-fluoro-l0-(4-aminsulfonyl- phenyl)-3-methyl-7-oxo-2,3-dihydro-(7H)-pyrido-(1,2,3 de)-1,4-benzoxazine-6-carboxylate (250 mg, 0.6 mmol), a 1N sodium hydroxide solution (7 ml) and ethanol (7 ml) was heated at 900C with stirring for 30 minutes. The reaction mixture was cooled to ambient temperature and was concentrated in vacuo. The milky suspension was neutralized with a 1N hydrochloric acid solution. The precipitate was filtered and washed with water. Drying in vacuo afforded a white powder (160 mg, 68% yield): m.p. 250 C. NMR (1% DMSO-d6/CF3CO2D, 250 MHz): 8.95 (s, 1H), 7.74 (d, 2R, J= 10 Hz), 7.65 (d, 1H, J = 10 Hz), 7.37 (d, 2H, J = 10 Hz), 4.85 4.70 (m, 1H), 4.30-4.15 (m, 2 H), 1.40 (d, 3H, J = 7 Hz). Anal.: Calcd. for Cl9H13FN2O6.2 H20: C, 50.21, H, 4.21, N, 6.16. Found: C, 50.50, H, 3.55, N, 6.25.

Claims: CLAMS FO DESIGNATED CONTRACTINr, STATES BE, CH, DE, FR, IT, LU, NL, SW, GB 1. A compound selected from those of the formula: EMI92.1 wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms1 benzyl or a pharmaceutically acceptable cation; R2 is hydrogen or fluoro; Y is selected from alkyl, haloalkyl and polyhaloalkyl of 1 to 3 carbon atoms, hydroxyethyl, cyclopropyl, vinyl, allyl, phenyl, 4-hydroxyphenyl and 4-fluorophenyl; R2 and Y when taken together have the formula -X-(CH2)n-CHR4- or EMI92.2 wherein X is CH2, O, S, NH or NCH3, n is O, 1 or 2, and R4 is hydrogen, alkyl or haloalkyl of I to 3 carbons, hydroxymethyl, hydroxyethyl, aminomethyl, or phenyl, and X is attached to the phenyl part of the quinoline group; and R3 is phenyl which may be substituted by one to three substituents selected from alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylmercapto of 1 to 4 carbon atoms, alkylsulfinyl of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, fluoro, chloro, trihalomethyl, hydroxy, hydroxyalkyl of 1 to 3 carbon atoms, amino, alkylamino of 1 to 4 carbon atoms, dialkylamino of 2 to 8 carbon atoms, aminoalkyl of 1 to 3 carbon atoms, alkylaminoalkyl of 2 to 8 carbon atoms, dialkylaminoalkyl of 3 to 9 carbon atoms7 formamido, dialkylformamido of 2 to 8 carbon atoms, alkanoylamino of 2 or 3 carbon atoms, formamidino, aminosulfonyl, alkylaminosulfonyl of 1 to 4 carbon atoms, dialkylaminosulfonyl of 2 to 8 carbon atoms, nitro, formyl, alkanoyloxy of 1 to 4 carbon atoms, ureido, alkylsulfonylamido of 1 to 4 carbon atoms, cyano, carboxamido, azidomethyl, carboxy, and alkylsilyloxymethyl of 4 to 13 carbon atoms with the proviso that R4 is not methyl when R3 is phenyl or phenyl substituted by one or two substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, alkylamino, alkanoylamido, and formamido, and Z is CH2, O or NCH3. 2. A compound according to claim 1 characterized in that R3 is phenyl which may be substituted at position 2, 3 or 4 by one substituent selected from hydroxy, hydroxymethyl, methoxy, amino, methylamino, aminomethyl, carboxy, formamido, nitro, aminosulfonyl, methylsulfinyl, methylsulfonyl, acetylamido, N-(N',N'- dimethylformamidino), cyano and formyl. 3. A compound according to claim 2 characterized in that a second substituent is present in the phenyl at any one of the vacant positions which substituent is selected from fluoro, chloro, methyl, hydroxymethyl, aminomethyl, carboxy, hydroxy, methoxy, methylthio, methylsulfinyl, methylsulfonyl, amino, methylamino, dimethylamino, nitro, carboxamido, aminosulfonyl, cyano and formyl. 4. A compound according to claim 1 characterized in that said compound is selected from 6,8-difluoro-7 phenyl-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-hydroxyphenyl)-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-l3-chloro-4-hydroxyphenyl)-1-ethyl-1,4- dihydroquinol-4-one 3-carboxylic acid 6,B-difluoro-7-(3-hydroxyphenyl)-1-ethyl-1,4-dihydro- quinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-aminomethylphenyl)-1-ethyl-1,4- dihydroquinol-4-one 3-carboxylic acid 6, 8-difluoro-7- (3-aminomethylphenyl) -1-ethyl-1, 4- dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(4-hydroxymethylphenyl)-1-ethyl-1,4dihydroquinol-4-one 3-carboxylic acid 6,8-difluoro-7-(3-hydroxymethylphenyl)-1-ethyl-1,4dihydroquinol-4-one 3-carboxylic ac-id 6,8-difluoro-7-(4-methylsulfinylphenyl)-1-ethyl-1,4dihydroquinol-4-one 3-carboxylic acid S,8-difluoro-7-(3- methylsulfonylphenyl) -1-ethyl- 1,4-dihydroquinol-4-one 3- carboxylic acid 6,8-difluoro-7-(4-methoxyphenyl)-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid and 6, 8-difluoro-7- (3-hydroxymethyl-4-hydroxy) -1-ethyl- 1,4-dihydroquinol-4-one 3-carboxylic acid. 5. A compound according to claim .1 characterized in that said compound is selected from 6-fluoro-7-phenyl-1-ethyl-1,4-dihydroquinol-4-one 3carboxylic acid 6-fluoro-7-l4-aminophenyl3-1-ethyl-1,4-dihydrOquinol-4- one 3-carboxylic acid 6-fluoro-7-(4-nitrophenyl)-l-ethyl-l,4-dihydroquinol-4- one 3-carboxylic acid 6-fluoro-7-(4-formamidophenyl}-1-ethyl-1,4-dihydroquin- ol- 4-one 3-carboxylic acid 6-fluoro-7-(4-acetamidophenyl)-1-ethyl-1,4-dihydroquinol-4-one 3-carboxylic acid 6-fluoro-7-(4-N-(N',N'-dimethylformamidino)phenyl)-lethyl-1,4-dihydroquinol-4-one 3-carboxylic acid 6-fluoro-7- (4-formylphenyl) -1-ethyl-I, 4-d-ihydroquinol- 4-one 3-carboxylic acid 6-fluoro-7-(4-hydroxymethylphenyl)-l-ethyl-1,4-dihydro- quinol-4-one 3-carboxylic acid 6-f luoro-7- (3-hydroxymethylphenyl) -l-ethyl-l, 4-dihydro- quinol-4-one 3-carboxylic acid and 6-fluoro-7-(4-aminosulfonylphenyl)-l-ethyl-l,4-dihydroquinol-4-one 3-carboxylic acid. 6. A compound according to claim 1 characterized in that said compound is 6-fluoro-7-(4-hydroxyphenyl)- 1-(4-fluorophenyl)-1,4-dihydroquinol-4-one 3-carboxylic acid. 7. A compound as claimed in claim 1 characterized in that said compound is 9-fluoro-10-(4 aminosulfonylphenyl) -3-methyl-7-oxo-2, 3-dihydro- (7H) - pyrido-(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid. 8. An antibacterial composition characterized by comprising a compound according to any one of claims 1 to 7 and a pharmaceutically acceptable carrier. 9. A compound of the formula defined in any one of claims 1 -to 7 or a pharmaceutically acceptable addition salt thereof, for use in medicine. CLAIMS FOR DESIGNATED CONTRACTING STATE AT 1. A process for the preparation of 7-substituted arylquinolones of the formula: EMI96.1 wherein R1 is hydrogen, alkyl of 1 to 6 carbon atoms or benzyl or a pharmaceutically acceptable cation; Y is alive or haloalkyl and polyhaloalkyl-of 1 to 3 cabbOn atans, cyclopropyl, hydroxyethyl, vinyl, allyl, phenyl, 4-hydroxyphenyl or 4-fluorophenyl; R2 is hydrogen or fluoro; R2 and Y when taken together have the formula -X-(CH2)n-CHR4- or EMI96.2 wherein X is CH2, O, S, NH or NCH3, n is 0, 1 or 2, and R4 is hydrogen, alkyl or haloalkyl of 1 to 3 carbons, hydroxymethyl, hydroxyethyl, aminomethyl, or phenyl, and X is attached to the phenyl part of the quinoline group; and R3 is phenyl which may be substituted by one to three substituents selected from alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylmercapto of 1 to 4 carbon atoms, alkylsulfinyl of 1 to 4 carbon atoms, alkylsulfonyl of 1 to 4 carbon atoms, fluoro, chloro, trihalomethyl, hydroxy, hydroxyalkyl of 1 to 3 carbon atoms, amino, alkylamino of 1 to 4 carbon atoms, dialkylamino of 2 to 8 carbon atoms, aminoalkyl of 1 to 4 carbon atoms, alkylaminoalkyl of 2 to 8 carbon atoms, dialkylaminoalkyl of 3 to 9 carbon atoms, formamido, dialkylformamido of 2 to 8 carbon atoms, alkanoylamino of 2 or 3 carbon atoms, formamidino, aminosulfonyl, aikylaminosulfonyl of 1 to 4 carbon atoms, dialkylaminosulfonyl of 2 to 8 carbon atoms, nitro, formyl, alkanoyloxy of 1 to 4 carbon atoms, ureido, alkylsulfonykzunido of 1 to 4 carbon atoms, cyano, carboxamido, carboxy, azidomethyl and tri alkylsilyloxymethyl of 4 to 13 carbon atoms, with the proviso that R4 is not methyl when R3 is phenyl or phenyl substituted by one or two substituents selected from alkyl, alkoxy, halogen, hydroxy, amino, alkyl amino, alkanoylamido, and formamido, and Z is CH2, O or NCH3; which comprises (a) reacting an arylmetallic compound containing aryl group R3 as defined above, except that R3 is not phenyl substituted with alkanoylamino or azidomethyl, with a compound of the formula: EMI97.1 wherein R is alkyl of 1 to 6 carbon atoms or benzyl; R2 and Y are as defined above, and R5 is bromo or iodo, in the presence of a transition metal catalyst, or (b) reacting a compound of the formula: : EMI97.2 wherein R1, R2 and R3 are as defined above, except that RI is not hydrogen, with a compound of the formula Y-Hal wherein Y is as defined above and Hal is halogen; and, where necessary, when R3 is nitrophenyl nitrating a corresponding compound wherein R3 is phenyl; when R3 is aminophenyl reducing a corresponding compound wherein R3 is nitrophenyl; when R3 is formamidophenyl reacting a corresponding compound wherein R3 is aminophenyl with formic acid or a formic acid derivative; when R3 is alkanoylaminophenyl reacting a corresponding compound wherein R3 is aminophenyl with an alkanoyl group containing reagent; ; when R3 is aminosulfonylphenyl reacting a corresponding compound wherein R3 is chlorosulfonylphenyl with an amino-introducing reagent obtaining said compound wherein R3 is chlorosulfonylphenyl by reacting a corresponding compound wherein R3 is phenyl with chlorosulfonic acid; when R3 is phenyl substituted by alkylaminosulfonyl or dialkylaminosulfonyl alkylating a corresponding compound wherein R3 is aminosulfonyl phenyl or reacting a compound wherein R3 is chlorosulfonylphenyl with a mono- or di- alkylamine; when R3 is hydroxyphenyl reacting a corresponding compound wherein R3 is methoxyphenyl with an ethercleaving reagent; when R3 is hydroxymethylphenyl reacting a corresponding compound wherein R3 is trialkylsilyloxymethylphenyl wherein each alkyl has 1 to 4 carbons with an ether-cleaving reagent; ; when R3 is aminomethylphenyl hydrogenating a corresponding compound wherein R3 is azidomethylphenyl; when R3 is azidomethylphenyl reacting a corresponding compound wherein R3 is methanesulfonyloxymethylphenyl with an azide; when R3 is formylphenyl by oxidizing a corresponding compound wherein R3 is hydroxymethylphenyl; when R3 is alkylaminophenyl or dialkylaminophenyl alkylating a corresponding compound wherein R3 is aminophenl; when R3 is alkylaminoalkylphenyl or dialkylaminoalkylphenyl alkylating a corresponding compound wherein R3 is aminoalkylphenyl; when R3 is ureidophenyl reacting a corresponding compound wherein R3 is aminophenyl with alkali metal cyanate; ; wllen R3 is alkylsulfinylphenyl or alkylsulfonylphenyl oxidizing a corresponding compound wherein R3 is alkylmercaptcphenyl; and when R1 is hydrogen hydrolyzing a corresponding compound wherein R1 is alkyl or benzyl, or hydrogenolyzing a corresponding compound wherein R1 is benzyl. 2. A process according to claim 1 wherein R3 is phenyl which may be substituted at position 2, 3 or 4 by one substituent selected from hydroxy, hydroxymethyl, amino, methylamino, aminomethyl, carboxy, formamido, nitro, aminosulfonyl, methoxy, methylsulfinyl, methylsulfonyl, acetylamido, cyano and formyl. 3. A process according to claim 2 wherein a second substituent is present in the phenyl at any one of the vacant positions which substituent is selected from fluoro, chloro, methyl, hydroxymethyl, aminomethyl, carboxy, hydroxy, methoxy, methylthio, methylsulfinyl, amino, methylamino, methylsulfonyl, dimethylamino, nitro, carboxamido, aminosulfonyl, cyano and formyl. 4. A process according to claim 1 wherein R1 is hydrogen, Y is 4-fluorophenyl, R2 is hydrogen and R3 is 4-hydroxyphenyl. 5. A process as claimed in claim 1 wherein said reaction (a) is carried out in an ether solvent. 6. A process as claimed in claim S wherein said ether solvent is selected from diethylether and tetra hydrofuran. 7. A process as claimed in claim 1 wherein the metal in said arylmetallic compound is magnesium, zinc, cadmium, tin, silver, copper, boron or aluminum. 8. A process as claimed in claim 7 wherein said metal is zinc. 9. A process as claimed in claim 1 wherein said arylmetallic compound is an arylzinc halide. 10. A process as claimed in claim 1 wherein said transition metal catalyst is in the (0) or (II) oxidation state. 11. A process as claimed in claim 10 wherein said transition metal in said catalyst is nickel, palladium or platinum. 12. A process as claimed in claim 10 wherein said transition metal catalyst is a complex containing a transition metal and a phosphorus-containing ligand. 13. A process as claimed in claim 12 wherein said catalyst is tetrakis (triphenylphosphine) palladillm. 14. A process as claimed in claim 12 wherein said catalyst is dichorobis(triphenylphosphine) nickel (II).

Inventors: GILLIGAN, PAUL J., MCGUIRK, PAUL R., WITTY, MICHAEL J.
Applicants: PFIZER INC.
Application year: 1985
Main classification: C07D215
IPC codes: C07D405, C07F7, C07D215, C07D498