AN EASILY WATER-DISPERSIBLE PROCYMIDONE-CONTAINING GRANULAR PREPARATION

Abstract: An easily water-dispersible granular preparation con­ tains procymidone [N-(3,5-dichlorophenyl)-1,2-­ dimethylcyclopropane-1,2-dicarboximide] as an active ingre­ dient and a water-soluble polymer as a dispersing agent. It is useful for controlling plant diseases and can be produced by spray drying an aqueous suspension containing procymi­ done and the water-soluble polymer.

Description: AN EASILY WATER-DISPERSIBLE PROCYMIDONE-CONTAINING GRANULAR PREPARATION The present invention relates to an easily water-dispersible procymidone (N-( 3,5-dichlorophenyl)- 1 ,2-dimethylcyclopropane-1 ,2-dicarboximidei-containing granular preparation (hereinafter referred to as present preparation) which can be produced by spray-drying an -aqueous-suspension containing procymidone as an active ingredient and a water-soluble polymer as a dispersing agent, its production and a method for controlling plant diseases with it. Well-known pesticidal preparations which are sprayed in dilution with water include emulsifiable concentrates, wettable powders and the like. But the emulsifiable concentrate, because it contains large quantities of organic solvent as a carrier, has problems such as inflammability, offensive smell, toxicity, irritation, etc., and besides that phytotoxicity becomes easy to appear on crops depending upon the active ingredient contained in it. Also, the wettable powder has a problem that, because it contains large quantities of inorganic substance as carriers, it is scattered in fine powders at the time of production and dilution with water. Procymidone, the active ingredient of the present preparation, has a high controlling effect on plant diseases such as stem rot, gray mold, etc. But, depending upon the number of times of spraying and spraying concentration as well as environmental conditions such as temperature, humidity, etc. and the kind and growing condition of crops, phytotoxicity sometimes appears on crops, thus resulting in a reduction in the yield of crops and a lowering in the quality thereof. The present inventors, with notice given to these problems, made an extensive study on pesticidal preparations containing procymidone as an active ingredient, and as a result, found that the present preparation produced, e.g., by spray-iryrng an-aqueous suspension containing procymidone as an active ingredient and a water-soluble polymer as a dispersing agent can solve these problems. The present inventors thus completed the present invention. The present preparation, like emulsifiable concentrates and wettable powders, can be sprayed in dilution with large quantities of water as well as in dilution with small quantities of water, that is, in high concentrations. Consequently, various problems involved in large-volume application of pesticidal preparation can be avoided. Further, the present preparation requires no auxiliaries other than a dispersing agent and besides has a small bulk and a good flowability, so that it is advantageous in many respects such as formulation, packing, storage, transport and the like. As the water-soluble polymer as the dispersing agent used in the present invention, there are given for example vegetable-origin polymers such as sodium alginate, gum arabic, gum tragacanth, etc., cellulose derivatives such as methyl cellulose, carboxymethyl cellulose, etc., water-soluble synthetic polymers such as polyvinyl alcohol, sodium polyacrylate, polyethylene glycol, etc., lignin sulfonic acid, alkylarylsulfonic acids, alkylnaphthalenesulfonic acid formalin condensates, metallic salts of these acids and mixtures thereof. Further, lauryl sulfates, dodecylbenzenesulfonates, etc. may be added in small amounts as need arises. To procymidone which is an active ingredient, fine powders of the following substances may be added as a filler if necessary: Polysaccharides such as cane sugar, grape sugar, milk sugar, dextrin, etc., fertilizers such as ammonium sulfate, ammonium phosphate, ammonium chloride, urea, etc., inorganic substances such as kaolin, calcite, talc, etc., synthetic resins such as polystyrene, polyvinyl chloride, polyethylene, etc., celluloses and the like. Other solid agricultural chemicals may be mixed as an active ingredient. The present preparation contains 10 to 95%, preferably 50 to 90% by weight of the active ingredient, 3 to 90%, preferably 5 to 50% by weight of the dispersing agent and a proper amount of the filler as need arises. For producing a preparation embodying the invention, an aqueous suspension of procymidone is produced by finely pulverizing procymidone on dry-pulverizers such as hammer mills, jet mills, etc. together with the filler and other solid agricultural chemicals if necessary and dispersing the pulverized product in an aqueous solution of the water-soluble polymers, or by wet-pulverizing a mixture of procymidone, an aqueous solution of the water-soluble polymers and if necessary the filler and other solid agricultural chemicals on wet-pulverizers such as attrition mills, sand grinders, etc. using glass beads of 0.5 to 2.0 mm in diameter, and then the aqueous suspension produced is spray-dried on spray-driers. The particle diameter of the active ingredient in the aqueous suspension is not more than 20 ta, preferably not more than 10 , and the total content of the active ingredient, water-soluble polymers and the filler added as need arises, is 20 to 70%, preferably 30 to 60%. Spray-drying is preferably carried out on a spray-drier of such specification that: It has a pressure spray nozzle; the diameter of the nozzle orifice is 0.5 to 3.0 mm; the spraying pressure is 3 to 20 kg/cm2; and the drying temperature is not more than 1500C by exhaust temperature. The present preparation thus produced is a granular preparation having a particle diameter of about 0.1 to about 1.0 mm. When the present preparation is diluted with water so that the concentration of procymidone, an active ingredient, is 250 to 500 ppm, the surface tension of this aqueous dilute liquid is not less than 60 dyne/cm which is higher than that of the aqueous dilute liquid of the conventional emulsifiable concentrate, wettable powder, etc., so that an improvement in the efficacy of procymidone and a reduction in the phytotoxicity thereof can be achieved. Practical and presently preferred embodiment for the production of the present preparation is as follows, wherein parts and % are by weight. Example 1 Eighty parts of procymidone was added to a solution of 15 parts of sodium dinaphthylmethanedisulfonate and 5 parts of sodium lignosulfonate in 200 parts of water and wet-pulverized for 60 minutes on a sand grinder using 300 parts of 12 to 28-mesh glass beads. Thereafter, the glass beads were removed by means of a 60-mesh wire net, and the separated suspension was spray-dried on a hot air parallel flow type spray drier equipped with a pressure spray nozzle of 1.0 mm in nozzle orifice diameter at a spraying pressure of 10 kg/cm2. A 80% procymidone-containing easily water-dispersible granular preparation was obtained. The content of 32 to 100-mesh granules of this preparation was 92%, and when this preparation was diluted with water so that the concentration of procymidone was 400 ppm, the surface tension of the aqueous dilute liquid was 69 dyne/cm. Example 2 Fifty parts of procymidone was added to a solution of 20 parts of sodium alkylnaphthalenesulfonate formalin condensate, 2 parts of gum arabic and 28 parts of urea in 150 parts of water, wet-pulverized and spraydried in the same manner as in Example 1 to obtain a 50% procymidone-containing easily water-dispersible granular preparation. The contents of granules having particle diameters of more than 32-mesh, 32 to 60-mesh and less than 60-mesh of this preparation were 3.2%, 85% and 11.8%, respectively. When this preparation was diluted with water so that the concentration of procymidone was 500 ppm, the surface tension of the aqueous dilute liquid was 63 dyne/cm. Examples of efficacy test and phytotoxicity test using the present preparation and a commercially available 50% procymidone-containing wettable powder will be shown. Efficacy test example Controlling effect on gray mold of cucumber (Botrytis cinerea) An aqueous dilute liquid of each of the present preparation and a commercially available 50% procymidone-containing wettable powder was sprayed by means of a spray gun onto cucumber seedlings in the cotyledonous stage cultivated in a flower pot of 9 cm in diameter so that the spray liquid was thoroughly attached to the leaf surface. The seedlings were inoculated with Botrytis cinerea at the day of spraying and seven days after the spraying and kept at 250C under a highly humid condition. Three days after the inoculation, the diameter of infected area was measured to obtain disease severity, and then control of disease was calculated from the following equation. The results are shown in Table 1. Disease Diameter of infected area severity 0 No infected area 1 Less than 5 mm 2 Not less than 5 mm to less than 10 mm 4 Not less than 10 mm to less than 15 mm 8 Not less than 15 mm Disease severity in ¯ disease severity Control of untreated plot - in treated plot x I X 100 disease = Disease severity in untreated plot (%) Table 1 EMI8.1 <tb> <SEP> Surface <SEP> tension <SEP> Concentration <tb> <SEP> of <SEP> aqueous <SEP> of <SEP> active <tb> <SEP> dilute <SEP> liquid <SEP> ingredient <tb> <SEP> (dyne/cm) <SEP> in <SEP> aqueous <tb> <SEP> dilute <SEP> liquid <tb> <SEP> (ppm) <tb> Aqueous <SEP> dilute <SEP> liquid <SEP> 71 <SEP> 62.5 <tb> of <SEP> the <SEP> present <SEP> pre- <SEP> 68 <SEP> 125 <tb> paration <SEP> of <SEP> Example <SEP> 1 <SEP> 67 <SEP> 250 <tb> Aqueous <SEP> dilute <SEP> liquid <SEP> 65 <SEP> 62.5 <tb> of <SEP> the <SEP> present <SEP> pre- <SEP> 64 <SEP> 125 <tb> paration <SEP> of <SEP> Example <SEP> 2 <SEP> 64 <SEP> 250 <tb> Aqueous <SEP> dilute <SEP> liquid <tb> of <SEP> the <SEP> commercially <SEP> 59 <SEP> 62.5 <tb> available <SEP> 50% <SEP> 57 <SEP> 125 <tb> procymidone-containing <SEP> 53 <SEP> 250 <tb> wettable <SEP> powder <tb> Untreated <SEP> plot <tb> (to be cont'd) EMI9.1 <tb> <SEP> Control <SEP> disease <SEP> (%) <tb> Inoculation <SEP> Inoculation <tb> at <SEP> the <SEP> day <SEP> seven <SEP> days <tb> of <SEP> spraying <SEP> after <SEP> spraying <tb> <SEP> 81.3 <SEP> 53.1 <tb> <SEP> 98.4 <SEP> 76.6 <tb> <SEP> 100 <SEP> 93.2 <tb> <SEP> 80.8 <SEP> 51.5 <tb> <SEP> 96.9 <SEP> 75.2 <tb> <SEP> 100 <SEP> 91.8 <tb> <SEP> 83.6 <SEP> 54.7 <tb> <SEP> 98.0 <SEP> 74.8 <tb> <SEP> 100 <SEP> 93.7 <tb> <SEP> O <SEP> O <SEP> <tb> Phytotoxicity test example An aqueous dilute liquid of each of the present preparation and a commercially available 50% procymidone-containing wettable powder was spryaed by means of a small automatic sprayer onto the young shoots of grape (variety, Delaware) cultivated in a flower pot of 9 cm in diameter so that the leaf surface was thoroughly wetted. Sixteen days after the spraying, the percentage of an area suffering from phytotoxicity was examined to obtain a phytotoxicity index, and the degree of phytotoxicity was calculated from the following equation. The results are shown in Table 2. Phytotoxicity Percentage of area suffering from index phytotoxicity 0 No area suffering from phytotoxicity 1 Less than 5% 2 Not less than 5% to less than 30% 3 Not less than 30% to less than 60% 4 Not less than 60% to less than 80% 5 Not less than 80% EMI10.1 <tb> Degree <SEP> of <SEP> z <SEP> khytotoxicity <SEP> index <SEP> x <SEP> numberx <tb> phytotoxicity <SEP> - <SEP> \of <SEP> leaves <SEP> ss <tb> Total <SEP> number <SEP> of <SEP> leaves <SEP> x <SEP> 5 <tb> Table 2 EMI11.1 <tb> <SEP> Surface <SEP> tension <tb> <SEP> of <SEP> aqueous <tb> <SEP> dilute <SEP> liquid <tb> <SEP> (dyne/cm) <tb> Aqueous <SEP> dilute <SEP> liquid <tb> of <SEP> the <SEP> present <SEP> pre- <SEP> 65 <tb> paration <SEP> of <SEP> Example <SEP> 1 <tb> Aqueous <SEP> dilute <SEP> liquid <tb> of <SEP> the <SEP> present <SEP> pre- <SEP> 63 <tb> paration <SEP> of <SEP> Example <SEP> 2 <tb> Aqueous <SEP> dilute <SEP> liquid <tb> of <SEP> the <SEP> commercially <tb> available <SEP> 50% <SEP> 47 <tb> procymidone-containing <tb> wettable <SEP> powder <tb> Untreated <SEP> plot <tb> (to be cont'd) EMI12.1 <tb> Concentration <SEP> Degree <SEP> of <tb> of <SEP> active <SEP> phytotoxicity <tb> ingredient <SEP> (8) <SEP> <tb> in <SEP> aqueous <tb> dilute <SEP> liquid <tb> (ppm) <tb> <SEP> 500 <SEP> 0.4 <tb> <SEP> 500 <SEP> 0.2 <tb> <SEP> 500 <SEP> 14.4 <tb> <SEP> ¯ <SEP> <tb>

Claims: What is claimed is: 1. An easily water-dispersible procymidonecontaining granular preparation which comprises said preparation can be produced by spray-drying an aqueous suspension containing procymidone as an active ingredient and a water-soluble polymer as a dispersing agent. 2. The preparation according to Claim 1, wherein the content of procymidone is 10 to 95% by weight. 3. The preparation according to Claim or 2, wherein the content of procymidone is 50 to 90% by weight. 4. The preparation according to Claim 1, 2 or 3, wherein the content of the water-soluble polymer is 3 to 90% by weight. 5. The preparation according ta Claim 1, 2, 3 or 4, wherein the content of the water-soluble polymer is 5 to 50% by weight. 6. A method for producing an easily waterdispersible procymidone-containing granular preparation which comprises spray-drying an aqueous suspension containing procymidone as an active ingredient and a watersoluble polymer as a dispersing agent. 7. The method according to Claim 6, wherein said aqueous suspension is produced by finely pulverizing procymidone on a dry-pulverizer and dispersing the pulverized product in an aqueous solution of the watersoluble polymers. 8. The method according to Claim 6, wherein said aqueous suspension is produced by wet-pulverizing mixture of procymidone and an aqueous solution of the water-soluble polymers on wet-pulverizer using glass beads of 0.5 to 2.0 mm in diameter. 9. A method for controlling plant diseases which comprises applying the easily water-dispersible procymidone-containing granular preparation according to Claim 1 to the plant. 10. A pesticide or fungicide preparation in granular form comprising procymidone as active ingredient and a water-soluble polymer as a dispersing agent.

Inventors: NODA, CHIKARA, OKAMOTO, YUKIKAZU, SAKODA, MITSUHARU, TAGAMI, MANABU, TSUJI, KOZO
Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED
Application year: 1984
Main classification: A01N37
IPC codes: A01N53, A01N25