HERBICIDAL PYRAZOLE-(THIO)-CARBOXAMIDES

Abstract: 1,5-Disubstituted-1H-pyrazole-4-carboxamide deriva­ tives, useful as herbicides and aquatic algicides.

Description: IMPROVEMENTS IN OR RELATING TO HERBICIDAL PYRAZOLES This invention relates to novel pyrazoles having herbicidal activity. In accordance with the invention it has been discovered that compounds of the formula (I):' EMI1.1 wherein R1 is C1-C6 alkyl, C5-C6 cycloalkyl, EMI1.2 Rê is halogen, C1-C4 alkyl, trifluoromethyl, C1-C4 alkoxy, C1-C4 alkylthio or C1-C4 alkylsulfonyl; R3 is hydrogen, C1-C4 alkyl or C1-C4 alkoxy; R4is cyclopropyl, C1-C4 alkyl or C1-C4 alkoxy; R5 is halogen, C1-C4 alkyl, C1-Cg alkoxy, C1-C4 haloalkyl, C1-C4 haloalkyl or nitro; X is o or S; and n is 0-3; with the following provisos: the combined total of carbon atoms for R3 and R4 does not exceed 5; when R1 is phenyl, R5is C1-C4 alkyl, and R2 is halogen, alkoxy, alkylthio, or alkylsulfonyl, the R5 substituent exists at other than the 2 or 6 position of the phenyl ring; when is C1-C4 alkoxy, R4 is other than C1-C4 alkoxy; and when R1 is phenyl, R5 is C1-C4 alkoxy and R2 is other than bromine, the R5 substituent exists at other than the 3 or 5 position of the phenyl ring, are useful both as herbicides and aquatic algicides. In the above formula, C1-C4 alkyl represents a straight or branched alkyl chain having from one to four -carbon atoms. Typical C1-C4 alkyl groups include methyl, ethyl, n-propyl, isopropyl, n-butyl, sec.butyl, t-butyl, and the like. C1-C6 alkyl includes the foregoing groups as well as C5 and C6 groups including pentyl, hexyl, tert-pentyl, and 1-methyl-1-ethylpropyl. C1-C4 Alkoxy represents a straight or branched alkoxy chain having from one to four carbon atoms. Typical C1-C4 alkoxy groups include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, sec.-butoxy, isobutoxy, t-butoxy, and the like. The terms "halogen1' or "halo" represent fluorine, chlorine, bromine and iodine. C1-C4 Raloalkyl represents a C1-C4 alkyl group bearing one or more halogen substituents-. Such haloalkyl groups include trifluoromethyl, 2,2,2-trifluoroethyl, pentabromoethyl, 3-chloropropyl, 2-iodopropyl, 4-fluorobutyl and the like. C1-C4 Hloaolkyl is a C1-c4 alkoxy group bearing one or more halogen atoms. Typical members of this classification include trifluoromethoxy, 1,1,2,2tetrafluoroethoxy, pentafluoroethoxy, 3 -bromopropoxy, 4-chlorobutoxy, 4-iodobutoxy and the like. C1-C4 Al kylthio represents a straight chain or branched alkylthio group having from one to four carbon atoms. Typical C1-C4 alkylthio groups include methylthio, ethylthio, n-propylthio, isopropylthio, nbutylthio, sec-butylthio, t-butylthio and the like. Preferred compounds have the above formula wherein RÚ is phenyl or tert-butyl, R2 is chlorine, bromine, or trifluoromethyl, R5 is halogen, n is 0 or 1, and R is hydrogen, methyl or ethyl and R4 is methyl, ethyl, or cyclopropyl. Particularly preferred compounds have the above formula wherein R3 is hydrogen and R4 is methyl or cyclopropyl. The compounds of the present invention can be prepared by procedures well known to those skilled in the art. The preferred process comprises the direct coupling of a 5-substituted-4-pyrazolecarboxylic acid with an appropriately substituted amine in the presence of a coupling reagent to provide the corresponding carboxamide according to the following reaction scheme: EMI3.1 This reaction process necessitates the use of a coupling reagent, for example any of the type of coupling reagents commonly employed in the synthesis of peptides. Examples of such coupling reagents include the carbodiimides such as N,Nfdicyclohexylcarbodi imide, N,N' -diisopropylcarbodiimide, or N,N1 -diethyl- carbodiimide; the imidazoles such as carbonyldiimidazole; as well as reagents such as N-ethoxycarbonyl-2-ethoxy1,2-dihydroquinoline (EEDQ). The direct coupling of a 4-pyrazolecarboxylic acid and an amine is carried out by adding about an equimolar quantity of the amine starting material to a solution of the carboxylic acid in the presence of an equimolar quantity or slight excess of coupling reagent. The reaction generally is carried out in an unreactive organic solvent such as dichloromethane or dimethylformamide, and usually is complete within about twenty-four hours when conducted at a temperature of about 0 to about 300C. The product is then typically isolated by filtration. The carboxamide product thus formed can be further purified if needed by any of several routine methods, including crystallization from common solvents, chromatography over solid supports such as silica or alumina, and related purification techniques. The carboxamides of the invention may also be prepared by reacting a 5-substituted-4-pyrazolecar- boxylic acid derivative with an appropriately substituted amine according to the following reaction scheme: EMI5.1 wherein R1, R2, R3 and R4 are as defined above and A is a good leaving group such as C1-C6 alkoxy, halogen or EMI5.2 alkyl). The preferred leaving group in this reaction is where A is halogen or C1-C6 alkoxy. This reaction can be carried out by combining the carboxylic acid derivative with about an equimolar quantity of the amine in a mutual solvent such as tetrahydrofuran, diethyl ether, dichloromethane, dioxane, dimethylsul- foxide, dimethylformamide, benzene, toluene, and the like. If desired, a base can be utilized in the acylation reaction when A is halogen to act as an acid scavenger. Commonly used bases include sodium carbonate, potassium carbonate, pyridine, triethylamine and related bases. Bases such as pyridine act as their own solvent and need no additional solvent. The reaction generally is substantially complete after about two to about 200 hours when carried out at a temperature of about 200 to about 200"C, preferably from about 300 to about 1000C. The product of the reaction may be isolated by simply removing the reaction solvent, for instance by evaporation under reduced pressure. Also, the reaction mixture may be added to water and the product collected by filtration or extracted into a water immiscible solvent. The product thus isolated can be further purified if desired by any of several well known techniques. Thiocarboxamides defined by the above general formula wherein X is sulfur form another important group of compounds that are herbicidally active and are a further embodiment of this invention. The thiocarboxamides of the invention are preferably prepared by thiating the corresponding carboxamide according to the following scheme: EMI6.1 Any of several thiating agents can be employed in this reaction, including phosphorus pentasulfide. An especially preferred thiating agent is Lawesson's Reagent, which is 2,-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphos- phetane-2,4-disulfide. This thiating reagent and its general use are described in detail in Tetrahedron Letters, 21, 4061 (1980). The thiation reaction is preferably carried out by reacting approximately equimolar quantities of a carboxamide and Lawesson's Reagent in a mutual organic solvent such as toluene - or dioxane. The reaction is generally complete within about one hour to about ten hours when carried out at a temperature of about 500 to about 1500C. The thiocarboxamide thus formed can be isolated and purified by normal methods, such as crystallization and the like. The 5-(substituted)-4-pyrazolecarboxylic acids and analogs thereof, used as starting materials to prepare the carboxamides of the invention are readily prepared by known procedures. The preferred process for the 4-pyrazolecarboxylic acids wherein R2 = halogen, alkoxy, alkylthio, or alkylsulfonyl involves reacting a hydrazine derivative with an alkyl (alkoxymethylene)cyanoacetate analog to prepare the corresponding 5-amino-4-pyrazolecarboxylic acid ester. The 5-amino group can then be converted to the 5-halogen, alkoxy, alkylthio, or alkylsulfonyl, and the ester subsequently hydrolyzed to the desired 4-pyrazolecarboxylic acid. The scheme for this reaction is represented by the following: EMI7.1 EMI8.1 wherein RÚ and n are as defined above, Rê is halogen, alkoxy, alkylthio, or alkylsulfonyl, and R6 is C1-C6 alkoxy. The reaction of a hydrazine with an alkyl (alkoxymethylene)cyanoacetate to prepare a 5-amino4-pyrazolecarboxylic acid ester is readily practiced by well known procedures. Typically, equimolar quantities of the two starting materials are combined in a suitable organic solvent such as methanol or ethanol. The mixture is stirred at a temperature in the range of from about 200 to 2000C, more preferably at the reflux temperature of the reaction mixture. The product thus formed after about 2 to 24 hours may then be isolated and purified acccrding to standard procedures. Conversion of the 5-amino group to the other 5-R2 groups is also carried out in known procedures. Those 4-pyrazolecarboxylic acid esters wherein R2 is chlorine, bromine or iodine are prepared by reacting a 5-amino-4-pyrazolecarboxylic acid ester derivative with a diazotizing agent in the presence of an appropriate halogenating agent depending on the desired halogen atom. The resulting ester may then be hydrolyzed to the acid or simply taken as is and converted to the amide as previously described. The scheme for the halogenation reaction is as follows: EMI9.1 wherein R1 is as defined above, R6 is C1-C4 alkoxy and Z is chlorine, bromine or iodine. Compounds wherein Z is chlorine in the immediately-preceding reaction scheme are prepared by employing nitrosyl chloride as both the diazotizing and halogenating agent. This reaction is typically performed in a non-reactive organic solvent and preferably in the presence of an acid catalyst. Typicalsolvents include most halogenated solvents with chloro form and carbon tetrachloride being preferred. An excess of the nitrosyl chloride is typically bubbled into the reaction mixture for about 5 to 30 minutes. The mixture may then be heated on a steam bath for a short period of time. The product may then be isolated by simply removing the volatiles under reduced pressure and purifying the product by common techniques if desired. Compounds of the present invention wherein Z is bromine or iodine in the above reaction scheme are prepared by employing an alkyl nitrite diazotizing agent and the corresponding halogen source as desired. Typical halogen sources include bromine, iodine, bromoform, iodoform and the like. Suitable alkyl nitrite reagents include but are not limited to t-butyl nitrite, isoamyl nitrite and the like. Typically the reaction is performed in a suitable organic solvent such as chloroform or carbon tetrachloride by addition of the alkyl nitrite dropwise into the reaction mixture. The reaction is usually complete after about 1 to 48 hours whenFconducted at a temperature of OOC to 1000C, more preferably at about 100C to 500C. Typically the reaction is worked up by simply evaporating the reaction mixture to dryness under reduced pressure and purifying the residue if desired by standard techniques such as crystallization or column chromatography. Compoundsof the invention wherein R2 is fluorine are preferably prepared by displacing chlorine from the corresponding pyrazolecarboxylic acid ester. This reaction is conducted by adding the appropriate starting material dissolved in a suitable solvent to an excess of the fluorinating agent. Suitable solvents include DMF and DMSO, with the latter being preferred. Typical fluorinating agents include the alkali metal fluorides such as sodium fluoride, potassium fluoride and cesium fluoride. Before being used in the reaction, the fluorinating agent should be dried so as to remove any residual water. Generally this can be performed by refluxing the fluorinating agent in a water immiscible solvent such as toluene. The solvent is then removed before combining the reaction ingredients. The reaction is substantially complete after about 1 to 48 hours when conducted at a temperature in the range from about 750C to about 2000C, more preferably from about 1000C to about 1500C, The product is then generally isolated by pouring the cooled reaction mixture into ice water and collecting the precipitated solid by filtration. The product thus isolated may then be purified if desired by routine procedures. The 4-pyrazolecarboxylic acid esters wherein R2 = alkoxy, alkylthio, or alkylsulfonyl can be prepared by subsequent reactions. For example, compounds of the present invention wherein R2 is C1-C4 alkoxy or C1-C4 alkylthio may be prepared by reacting an appropriately substituted 5-halogen-4-pyrazolecarboxylic acid ester with an alkali metal alkoxy or alkylthio derivative according to well known procedures. Compounds wherein R2 is C1-CA alkylsulfonyl are prepared by oxidizing the corresponding alkylthio derivative with a suitable oxidizing agent such as hydrogen peroxide or the peracids The 5-alkyl and 5-(trifluoromethyl)-4-pyrazolecarboxylic acids are prepared by the following reaction scheme: EMI12.1 wherein R7 = C1-C4 alkyl or trifluoromethyl. The reaction of a hydrazine with an alkyl (alkoxymethylene)trifluoroacetoacetate is readily practiced by known procedures. Typically the reaction is carried out in a suitable solvent such as methanol or ethanol, and at temperatures of from -25 to 0 C. Preferably equimolar quantities of the reactants are employed Triethylamine or another acid scavenger can be employed. The product can be worked up in conventional procedures. Compounds wherein R2 is C1-C4 alkyl may also be prepared by reacting 3-phenyl-4-alkylsydnone with a vinyl acetate derivative to give the corresponding 5-alkyl pyrazole ester which can then be converted to the amide as described herein. The conversion of the pyrazole carboxylic acid esters to the corresponding carboxylic acids is accomplished by well known hydrolysis conditions. This reaction is typically performed with a suitable base in a mutual organic solvent such as aqueous methanol or ethanol. Suitable bases include the alkali metal hydroxides, preferably sodium hydroxide and potassium hydroxide. Typically the reaction mixture is refluxed for about 1 to 24 hours and then acidified. The resulting precipitate may then be either extracted into a water immiscible solvent or collected by filtration. Purification may be performed if desired by any one of many standard techniques. The hydrazine and alkyl (alkoxymethylene)cyanoacetate starting materials are either commercially available or readily prepared by known procedures. For example, phenylhydrazine compounds are readily prepared by reacting an appropriately substituted aniline with nitrous acid and then stannous chloride according to known procedures. The alkyl (alkoxymethylene)tri- fluoroacetoacetates are prepared by the method of R. Jones at J. Am. Chem. Soc., 73, 3684 (1951). The following Examples are illustrative of compounds of the present invention, as well as methods of their preparation. These Examples are not intended to be limiting to the scope in any respect and should not be so construed. Example 1 5-Bromo-1-phenyl-N-methyl-1H-pyrazole-4carboxamide A. 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester. A solution of 31.9 g of phenylhydrazine and 50.0 g of ethyl (ethoxymethylene)cyanoacetate (both reactants were obtained from Aldrich Chemical Company, Milwaukee,.Wisconsin) dissolved in 500 ml of ethanol was refluxed for 6 hours. The mixture was allowed to stand for approximately 48 hours and was refluxed for an additional 8 hours. The reaction mixture was poured into ice water and the precipitated solid was collected by filtration. The solid was recrystallized from ethanol to afford 38.0 g of 5-amino-l-phenyl-lE-pyra- zole-4-carboxylic acid, ethyl ester. Yield 44%. mp = 1010-1030C Analysis calculated for C12R13N3O2 Theory: C, 62.33; H, 5.67; N, 18.17; Found: C, 62.11; H, 5.59; N, 18.00. B. 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester To a solution of 20.0 g of 5-amino-l-phenyl lh-pyrazole-4-carboxylic acid, ethyl ester and 10 ml of bromine in 200 ml of chloroform was added 15.8 g of isoamyl nitrite dropwise. The reaction mixture was allowed to stir at room temperature for about 24 hours and the volatiles were removed under reduced pressure. The residue was recrystallized from ethanol/water to provide 10.0 g of 5-bromo-1-phenyl-1H-pyrazole-4-car- boxylic acid, ethyl ester. Yield 38%. mp = 86-89 C C. 5-Bromo-1-phenyl-1H-pyrazole-4-carboxylic acid A mixture of 15.5 g of 5-bromo-1-phenyl-1H- pyrazole-4-carboxylic acid, ethyl ester and 14 g of potassium hydroxide in 300 ml of 3A ethanol was refluxed for 3 hours. The solution was poured into ice water and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration and recrystallized from ethanol/water to afford 9.0 g of 5-bromo-l-phenyl-lH-pyrazole-4-carboxylic acid. Yield 64%. mp = 2l80-2220C D. - Three grams of 5-bromo-1-phenyl-lE- pyrazole-4-carboxylic acid and 2.6 g of carbonyldiimidazole were dissolved in 50 ml of dimethylform2mide. The mixture was allowed to stir for 20 minutes and 7 ml of 40% aqueous methylamine was added to the reaction mixture. The mixture was stirred for 2 hours at room temperature and poured into ice water. The precipitated solid was collected by filtration and recrystallized from ethanol/water to afford 1.3 g of 5-bromo-lphenyl-N-methyl-1H-pyrazole-4-carboxamide. Yield 42%. ;np = 1570-1590C Analysis calculated for C11H10BrN3O Theory: C, 47.17; H, 3.60; N, 15.00; Found: C, 46.96; H, 3.57; N, 14.97. Example 2 -Chloro-1-(4-methoxyphenyl)-N-methyl-1Hpyrazole-4-carboxamide A. 5-Amino-1-(4-methoxyphenyl)-1H-pyrazole4-carboxylic acid, ethyl ester Twenty grams of (4-methoxyphenyl)hydra:ine hydrochloride, 18.6 g of ethyl (ethoxymethylene)cyanoacetate and 15.2 g of potassium carbonate were combined with 200 ml of ethanol and refluxed for 20 hours. The mixture was cooled and poured into ice water. The precipitated solid was collected by filtration, dried and recrystallized from ethanol to afford 8.1 g of 5-amino-l- (4-methoxyphenyl) -lH-pyrazole-4- carboxylic acid, ethyl ester. Yield 28%. mp = 2090- 2110C Analysis calculated for C13H15N303 Theory: C, 59.76; H, 5.79; N, 16.08; Found: C, 59.93; H, 5.79; N, 15.80. B. 5-Chloro-1-(4-methoxyphenyl)-1H-pyrazole4-carboxylic acid, ethyl ester Nitrosyl chloride was bubbled into a stirring solution of 8.0 g of 5-amino-l-(4-methoxyphenyl)-1H- pyrazole-4-carboxylic acid, ethyl ester in 150 ml of chloroform for 15 minutes. The reaction mixture was ten placed on a steam bath for 5 minutes and cooled. The solvent was removed under reduced pressure and the residue recrystallized from ethanol to provide 7.5 g of 5-chloro-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid, ethyl ester. Yield 908. me = 100 -101 C Analysis calculated for C13H13C1N2 0 3 Theory: C, 55.62; H, 4.67; N, 9.98; C1, 12.63; Found: C, 55.50; H, 4.45; N, 10.01; C1, 12.92. C. 5-Chloro-1-(4-methoxyphenyl)-1H-pyrazole4-carboxylic acid A solution of 7.5 g, of 5-chloro-1-(4methoxyphenyl)-1H-pyrazole-4-carboxylicacid, ethyl ester and 2.8 g of potassium hydroxide in 200 ml of 3A ethanol was refluxed for 4 hours. The mixture was poured into ice water and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration, dried and recrystallized from ethanol to afford 4.2 g of 5-chloro-l-(4-methoxyphenyl)- lH-pyrazole-4-carboxylic acid. Yield 65%. mp = 241-2420C Analysis calculated for C11H9C1N2 0 Theory: C, 52.29; H, 3.59; N, 11.09; C1, 14.03; Found: C, 52.38; H, 3.78; N, 10.80; C1, 13.73. D. To a solution of 1.2 g of 5-chloro-l (4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid in 150 ml DMF was added 1.1 g of carbonyldiimidazole and the mixture was allowed to stir at room temperature for 20 minutes. One gram of triethylamine and 0.6 g of methyl amine hydrochloride were next added to the reaction mixture and the solution was stirred at room tem perature for 20 hours. The mixture was poured into ice water and extracted with ethyl acetate. The organic phase was separated and washed with water, dried, and concentrated under vacuum to dryness. The residue was recrystallized from toluene/hexane to afford 650 mg of 5-chloro-1-(4-methoxyphenyl)-N-methyl-lH-pyrazole-4- carboxamide. Yield 718. mp = 1440-1460C Analysis calculated for C12H12C1N3O2 Theory: C, 54.25, H, 4.55; N, 15.82; Found: C, 54.35; H, 4.74; N, -15.87. Example 3 5-Chloro-1-(3-chlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide A. 5-Amino-1-(3-chlorophenyl)-1H-pyrazole 4-carboxylic acid, ethyl ester A solution of 53.7 g of (3-chlorophenyl)hydrazine hydrochloride, 50.8 g of ethyl (ethoxymethylene)cyanoacetate and 41.4 g of potassium carbonate in 500 ml of ethanol was refluxed for 20 hours. The solution was poured into ice water. The precipitated solid was collected by filtration, dried and recrystallized from ethanol/water to provide 53.0 g of 5-amino-1(3-chlorophenyl)-1H-pyrazole-4-carboxylic acid, ethyl ester. Yield 67%. mp = 1150-1170C Analysis calculated for C 12H12C1N3O2 Theory: C, 54.25; H, 4.55; N, 15.82; Found: C, 54.08; H, 4.39; N, 15.75. B. 5-Chloro-1-(3-chlorophenyl)-1H-pyrazole4-carboxylic acid, ethyl ester Nitrosyl chloride was bubbled into a cold solution of 10.0 g of 5-amino-l-(3-chlorophenyl)-l- pyrazole-4-carboxylic acid, ethyl ester in 150 ml of chloroform for 20 minutes. The reaction mixture was then placed on a steam bath for five minutes and the volatiles were removed under reduced pressure. The residue was recrystallized from ethanol to afford 7.8 g of S-chloro-l- (3-chlorophenyl) -lH-pyrazole-4-carboxylic acid, ethyl ester. Yield 80%. mp = 610-630C Analysis calculated for C12H10C12N2O2 Theory: C, 50.55; H, 3.54; N, 9.82; Found: C, 50.78; H, 3.29; N, 10.04. C. 5-Chloro-1-(3-chlorophenyl)-1H-pyrazole4-carboxylic acid A mixture of 7.8 g of 5-chloro-l-(3-chloro- phenyl)-1H-pyrazole-4-carboxylic acid, ethyl ester and 3.0 g of potassium hydroxide in 200 ml of 3A ethanol was refluxed for four hours. The solution was poured into ice water and acidified wlth hydrochloric acid. The aqueous acid solution was extracted with ethyl acetate. The organic phase was washed with water, dried, and concentrated under vacuum. The residue was recrystallized fom ethanol to afford 5.7 g of 5-chloro1-(3-chlorophenyl)-1H-pyrazole-4-carboxylic acid. Yield 80% . mp = 209 -211 C D. A solution of 5.7 g of 5-chloro-l-(3chlorophenyl)-1H-pyrazole-4-carboxylic acid and 5.4 g of carbonyldiimidazole in 150 ml DMF was stirred at room temperature for 20 minutes. Next, 3.0 g of methylamine hydrochloride and 4.4 g of triethylamine were added and the mixture was stirred at room temperature for 20 hours. The mixture was poured into ice water and the precipitated solid was collected by filtration and dried. The solid was recrystallized from toluene to provide 3.1 g of 5-chforo-1-(3-chlorophenyl)-N-methyl-1H-pyrazole-4-crboxamide. Yield 50 %. mp = 1630-1650C Analysis calculated for C11H9C12N30 Theory: C, 48.91, H, 3.36; N, 15.56; C1, 26.25; Found: C, 48.68; H, 3.52; N, 15.64; C1, 26.35. Example 4 -Chloro-1-(3-chlorophenyl)-N-methyl-1H pyrazole-4-thiocarboxamide A solution of 3.0 g of 5-chloro-l-(3-chloro- phenyl)-N-methyl-1H-pyrazole-4-carboxamide and 6.5 g of Lawesson's Reagent in 159 ml toluene was refluxed for one hour. The solution was cooled and the volatiles were removed under reduced pressure. The residue was chromatographed. over silica gel eluting with methylene chloride. The fractions containing the major component were combined and the solvent was evaporated therefrom to afford 1.6 g, following recrystallization from toluene,of 5-chloro-1-(3-chlorphenyl)-N-methyl-1Hpyrazole-4-thiocarboxamide. Yield 56%. mp = 128-130 C Analysis calculated for C11H9C12N3S Theory: C, 46.17; H, 3.17; N, 14.68; S, 11.20; Found: C, 46.27; H, 3.33; N, 14.79; S, 10.95. Example 5 5-Bromo-1-phenyl-N,N-dimethyl-1H-pyrazole4 -carboxamide Three grams of 5-bromo-I-phenyl-lH-pyrazole- 4-carboxylic acid and 2.6 g of carbonyldiimidazole was dissolved in 50 ml of DMF. The solution was stirred for 20 minutes and 2.3 g of triethylamine and 1.8 g of dimethylamine hydrochloride were added to the reaction mixture. The mixture was stirred at room temperature for 3 hours and was poured into ice water. The precipitated solid was collected by filtration and recrys tallized from ethanol/water to afford 1.2 g of 5-bromo1-phenyl-N,N-dimethyl-1H-pyrazole-4-carboxamide. Yield 37%. mp = 79-81 C Analysis calculated for c12H12BrN3O Theory: C, 49.00; F, 4.11; N, 14.29; Found: C, 4S.90; H, 4.08; N, 14.03. Example 6 5-Bromo-1-phenyl-N-ethyl-1H-pyrazole-4carboxamide A solution of 2.6 g of 5-bromo-1-phenyl-1H- pyrazole-4-carboxylic acid and 2.4 g of carbonyldiimidazole in 50 ml DMF was stirred at room-temperature for 30 minutes. Five milliliters of 70% aqueous ethylamine was next added to the solution and the mixture was stirred for an additional two hours at room temperature. The reaction mixture was poured into ice water and the precipitated solid was collected by filtration. The solid was recrystallized from ethanol to afford 1.0 g of 5-bromo-1-phenyl-N-ethyl-1H-pyrazole-4-car- boxamide. Yield 34%. mp = 158 -160 C Analysis calculated for C12Hl2BrNrO Theory: C, 49.00; H, 4.11; N, 14.29; Found: C, 48.74; H, 3.84; N, 14.42. Example 7 5-Bromo-1-phenyl-N-methoxy-1H-pyrazole-4carboxamide A solution of 2.6 g of 5-bromo-l-phenyl-13- pyrazole-4-carboxylic acid and 2.4 g of carbonyldi imidazole in 60 ml DMF was stirred at room temerature for 30 minutes. Two grams of triethylamine and 1.7 g of methoxyamine hydrochloride were added to te solution. The mixture was stirred at room temperature for 24 hours and another equivalent of triethylamine and methoxyamine hydrochloride were added. The mixture was heated on the steam bath for two hours and poured into ice water. The precipitated solid was collected by filtration and recrystallized from ethanol to afford 1.0 g of 5-bromo-1-phenyl-N-methoyxy-1H-pyrazole-4- carboxamide. Yield 34%. mp = 194-197 C Analysis calculated for C11H10BrN3O2 Theory: C, 44.59; H, 3.38; N, 14.19; Found: C, 44.33; H, 3.08; N, 13.71. The following Example represents an illustra- tion of a reaction of a carboxylic acid, ethyl ester with an amine to provide a compound of the invention. Example 8 5-Chloro-1-phenyl-N-methyl-1H-pyrazole-4carboxamide A solution of 3.5 g of 5-chloro-l-phenyl-lH- pyrazole-4-carboxylic acid, ethyl ester and 20 ml of 40% acueous methylamine in 20 ml DMF was stirred at room temperature for about 45 hours. Thin layer chromatography showed mostly starting material so an additional 10 ml of 40% acueous methylamine was added to the reaction mixture which was stirred for an additional 5 days. The reaction mixture was poured into ice water and the precipitated solid was collected by filtration. After drying, the solid was recrystallized from toluene to afford 2.3 g of 5-chloro-1-phenyl-N-methyl-1H-pyra- zole-4-carboxamide. Yield 708 mp = 182 -183°C Analysis calculated for C11H10ClNO3 Theory: C, 56.06; H, 4.28; , 17.83; Found: C, 56.33; E, 4.21; N, 17.77. The following Examples of carboxamides of the invention-were prepared either by the reaction of an appropriate carboxylic acid with an amine according to the general procedures outlined above, or by the modification of a present carboxamide. Example 9 5-Iodo-1-phenyl-N,N-dimethyl1H-pyrazole-4carboxamide, mp = 930-940C Analysis calculated for C12H12IN3O Theory: C, 42.25; H, 3.55; N, 12.32; Found: C, 41.98; R, 3.40; N, 12.06. Example 10 5-Chloro-1-(3,5-dichlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1710-1730C Analysis calculated for C11H8Cl33O Theory: C, 43.38; , 2.65; N, 13.80; Found: C, 43.64; H, 2.86; N, 14.05. Example 11 5-(Methylsulfonyl)-1-pehnyl-N-methyl-1Hpyrazole-4-carboxamide, mp = 162-164 C Analysis calculated for C12H13N303S Theory: C, 51.60; H, 4.69; N, 15.04; Found: C, 51.53; H, 4.56; N, 14.93. Example 12 5-Methyl-1-phenyl-N-methyl-1H-pyrazole4-carboxamide, mp = 174-177 C Analysis calculated for C12El3N30 Theory: C, 66.96; H, 6.09; N, 19.52; Found: C, 66.75; H, 6.07; N, 19.28. Example 13 5-Chloro-1-(2,3,4-trichlorophenyl)-N-methyl 1H-pyrazole-4-carboxamide, mp = 207 -209 C Analysis calculated for C11H7Cl4N3O Theory: C, 38.97; H,.2.08; N, 12.39; Found: C, 39.25; H, 2.09; N, 12.24. Example 14 5-Bromo-1-(2,4,6-trichlorophenyl)-N-methyl lR-pyrazole-4-carbokamide, mp = 187 -194 C Analysis calculated for C11H7BrCl3NO Theory: C, 34.46; H, 1.84; N, 10.96; Found: C, 34.66; H, 1.77; N, 11.14. Example 15 5-Chloro-1-phenyl-N-propyl-1H-pyrazole-4carboxamide, mp = 116-118 C Analysis calculated for C13H14ClN3O Theory: C, 59.21; H, 5.35; N, 15.93; C1, 13.44; Found: C, 59.49; H, 5.31; N, 15.05; C1, 13.52. Example 16 5-Chloro-1-phenyl-N-ethyl-1H-pyrazole-4carboxamide, mp = 139 -141 C Analysis calculated for C12H12ClN3O Theory: C, 57.72; H, 4.84; N, 16.83; C1, 14.20; Found: C, 57.73; H, 5.00; N, 16.73; C1, 14.13. Example 17 5-Bromo-l-phenyl-N-propyl-lH-pyrazole-4carboxamide, mp = 1410-1430C Analysis calculated for C13Hl4BrN3O Theory: C, 50.67; H, 4.58; N, 13.64; Found: C, 50.65; H, 4.40; N, 13.41. Example 18 5-Iodo-l-phenyl-N-methyl-lH-pyrazole-4carboxamide, mp = 1820-1840C Analysis calculated for C11H10IN3O Theory: C, 40.39; H, 3.08; N, 12.85; Found: C, 40.26; H, 3.07; N, 12.80. Example 19 5-Chloro-1-(2-chlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 141 -143 C Analysis calculated for C11H9Cl2N3O Theory: C, 48.91; H, 3.36; N, 15.56; Found: C, 48.70; H, 3.28; N, 15.49. Example 20 5-Chloro-1-(2-methoxypehnyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 148 -150 C Analysis calculated for C12H1ClN3O2 Theory: C, 54.25; H, 4.55; N, 15.82; Found: C, 54.16; H, 4.51; N, 15.97. Example 21 5-Chloro-1-[2-(trifluoromethyl)pehnyl]-N methyl-lH-pyrazole-4-carboxamide, mp = 1450-1470C Analysis calculated for C12H9C1F3N30 Theory: C, 47.46; H, 2.99; N, 13.84; Found: C, 47.62; H, 2.91; N, 13.90. Example 22 5-Bromo-1-[2-trifluoromethyl)pehnyl]-Nmethyl-lH-pyrazole-4-carboxamide, mp = 1540-1560C Analysis calculated for C12H9BrF3N3 0 Theory: C, 41.40; H, 2.61; N, 12.07; Found: C, 41.61; H, 2.49; N, 11.90. Example 23 5-Chloro-1-[3-(trifluoromethyl)phenyl]-Nmethyl-1H-pyrazole-4-carboxamide, mp = 148 -150 C Analysis calculated for C12H9ClF3N3O Theory: C, 47.46; H, 2.99; N, 13.84; Found: C, 47.53; H, 3.02; N, 14.02. Example 24 5-Bromo-1-[3-(trifluoromethyl)pehnyl]-N methyl-lH-pyrazole-4-carboxamide, mp = 1290-1310C Analysis calculated for C12H9BrF3N3O Theory: C, 41.40; H, 2.61; N, 12.07; Br, 22.95; Found: C, 41.22; H, 2.50; N, 11.86; Br, 23.11. Example 25 5-Bromo-1-(2,3,4-trichlorophenyl)-N-methyl lH-pyrazole-4-carboxamide, mp = 1930-1950C Analysis calculated for C11H7BrCl3N3O Theory: C, 34.46; H, 1.84; N, 10.96; Found: C, 34.67; H, 1.74; N, 10.86. Example 26 5-Chloro-1-[3-(trifluoromethyl)phenyl]-N,N N-ethyl-lH-pyrazole-4-carboxamide, mp = 111 -113 C Analysis calculated for C13H11ClF3N3O Theory: C, 49.15; H, 3.49; N, 13.23; Cl, 11.16; Found: C, 49.06; H, 3.31; N, 13.25; Cl,' 10.95, Example 27 5-Bromo-1-[3-(trifluoromethyl)phenyl]-N,Ndimethyl-1H-pyrazole-4-carboxamide, mp = SSOC Analysis calculated for C13H11BrF3N3O Theory: C, 43.12; , 3.06; N, 11.60; Br, 22.06; Found: C, 42.87; H, 2.92; N, 11.38; Br, 22.16. Example 28 5-Chloro-1-(3,4-dimethylphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 156 -158 C Analysis calculated for C13H14ClN3O Theory: C, 59.21; H, 5.35; N, 15.93; Found: C, 59.27; H, 5.07; N, 15.73. Example 29 5-Chloro-1-(3-nitrophenyl)-N,N-dimethyl-1Hpyrazole-4-carboxamide, mp = 1180-1200C Analysis calculated for C12H11ClN4O3 Theory: C, 49.02; H, 3.76; N, 19.01; Found: C, 49.08; H, 3.64; N, 19.24. Example 30 5-Chloro-1-(3-nitropehnyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 163 -165 C Analysis calculated for C11H9C1N403 Theory: C, 47.07; H, 3.23; N, 19.96; Found: C, 46.80; H, 3.08; N, 19.85. Example 31 5-Bromo-1-(3-fluorphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 144 -145 C Analysis calculated for C11H9BrFN3O Theory: C, 44.32; H, 3.04; N, 14.10; Found: C, 44.54; H, 2.9a; N, 13.93. Example 32 5-Chloro-1-(2,4,5-trichlorophenyl)-N-methyllH-pyrazole-4-carboxamide, mp = 1930-1950C Analysis calculated for C11H7Cl4N3O Theory: C, 38.97; H, 2.08; N, 12.39; Found: C, 39.18; H, 1.82; N, 12.14. Example 33 5-chloro-1-(2,4,6-tribromophenyl)-N-methyl lH-pyrazole-4-carboxamide, mp = 183 -185 C Analysis calculated for CllH7Br3ClN3O Theory: C, 27.97; H, 1.49; N, 8.90; Found: C, 28.57; H, 1.67; N, 9.06. Example 34 5-Chloro-1-(3-fluorophenyl)-N-ethyl-1Hpyrazole-4-carboxamide, mp - 1220-1230C Analysis calculated for C12H11ClFN3O Theory: C, 53.84; H, 4.14; N, 15.70; Found: C, 53.63; H, 4.09; N, 15.80. Example 35 5-Chloro-1-(3-fluorophenyl)-N,N-dimethyllH-pyrazole-4-carboxamide, mp = 1220-1230C Analysis calculated for C12H11ClFN3O Theory: C, 53.84; H, 4.14; N, 15.70; Found: C, 53.66; H, 4.16; N, 15.81. Example 36 5-Chloro-1-(3-fluoropehnyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 163 -165 C Analysis calculated for C11H 9C1FN30 Theory: C, 52.08; H, 3.58; N, 16.57; Found: C, 51.81; H, 3.40; N, 16.47. Example 37 5-Chloro-l-(4-nitrophenyl)-N-methyl-IH- pyrazole-4-carboxamide, mp = 1650-1670C Analysis calculated for C11H9ClN4O3 Theory: C, 47.07; H, 3.23; N, 19.96; Found: C, 47.33; H, 3.31; N, 19.95. Example 38 5-Chloro-1-(4-nitrophenyl)-N,N-dimethyl lR-pyrazole-4-carboxamide, mp = 1490-1520C Analysis calculated for C12H11ClN4O3 Theory: C, 48.91; H, 3.76; N, 19.01; Found: C, 49.18; H, 4.01; N, 18.85. Example 39 5-Bromo-1-(4-nitrophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 172 -175 C Analysis calculated for C11H9BrN4O3 Theory: C, 40.64; H, 2.79; N, 17.23; Found: C, 40.88; H, 2.72; N, 17.19. Example 40 5-bromo-1-(3-chlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 124 -125 C Analysis calculated for C11H9BrClN3O Theory: C, 42.00; H, 2.88; N, 13.36; C1, 11.27; Br, 25.40; Found: C, 41.72; H, 3.00; N, 13.11; C1, 11.06; Br, 25.26. Example 41 5-Chloro-1-(3-chlorophenyl)-N-methoxy-1Hpyrazole-4-carboxamide, mp = 740-760C Analysis calculated for C11H9Cl2N3O2 Theory: C, 46.18; H, 3.17; N, 14.69; Found: C, 46.08; H, 3.26; N, 14.47. Example 42 5-Chloro-1-(2,5-dichloropehnyl)-N-methyllH-pyrazole-4-carboxamide, mp = 1660-1680C Analysis calculated for c11H8Cl3N3O Theory: C, 43.38; H, 2.65; N, 13.80; Found: C, 43.61; H, 2.62; N, 14.01. Example 43 5-Bromo-1-(3-chlorophenyl)-N,N-dimethyllH-pyrazole-4-carboxamide, mp = 820-840C Analysis calculated for C12H11BrClN3O Theory: C, 43.86; , 3.37; N, 12.79; C1, 10.79; Br, 24.32; Found: C, 43.56; H, 3.35; N, 12.52; C1, 10.82; Br, 24.35. Example 44 5-Chloro-1-(3-chlorophenyl)-N,N-dimethyl-1Hpyrazole-4-carboxamide, mp = 1010-1030C Analysis calculated for C12HllC12N3O Theory: C, 57.72; H, 3.90; N, 14.71; Found: C, 57.70; H, 3.68; N, 14.81. Example 45 5-Bromo-1-(3-methoxyphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 159 -160 C Analysis calculated for C12H12BrN3 02 Theory: C, 46.47; H, 3.90; N, 13.55; Found: C, 46.63; H, 3.88; N, 13.56. Example 46 5-Bromo-1-(2,4-difluoropehnyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1290-1300C Analysis calculated for C11H8BrF2N3O Theory: C, 41.80; H, 2.55; N, 13.29; Found: C, 41.91; H, 2.68; N, 13.22. Example 47 5-Chloro-1-(4-fluorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 57 -159 C Analysis calculated for C11H9ClFN3O Theory: C, 52.08; H, 3.58; N, 16.57; Cl, 13.98; Found: C, 51.79; H, 3.50; N, 16.75; C1, 14,01. Example 48 5-chloro-1-(4-fluoropehnyl)-N-methyl-1Hpyrazole-4-thiocarboxamide, mp = 1570-1590C Analysis calculated for C11H9ClFN3S Theory; C, 48.98; H, 3.36; N, 15.58; S, 11.89; Found: C, 49.21; H, 3.31; N, 15.45; S, 11.67. Example 49. 5-Chloro-1-(4-fluorophenyl)-N,N-dimethyl-1H pyrazole-4-carboxamide, mp = 1390-1410C Analysis calculated for C12H11ClFN3O Theory: C, 53.84; H, 4.14; N, 15.70; Cl, 13.24; Found: C, 53.79; H, 4.10; N, 15.88; Cl, 13.49. Example 50 5-Chloro-l-(4-fluorophenyl)--ethyl-IH- pyrazole-4-carboxamide, mp = 172 -174 C Analysis calculated for C12H11C1FN30 Theory: C, 53.84; H, 4.14; N, 15.70; Found: C, 54.12; H, 4.09; , 15.75. Example 51 5-Chloro-1-(4-fluorophenyl)-N-methoxy-1H¯ pyrazole-4-carboamide, mp = 178 -180 C Analysis calculated for C11H9ClFN3O2 Theory: C, 48.99; H, 3.36; N, 15.58; Found: C, 48.78; H, 3.57; N, 15.77. Example 52 5-bromo-1-(4-fluorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1770-1780C Analysis calculated for C11H9BrFN3O Theory: C, 44.32; H, 3.04; N, 14.10; Found: C, 44.60; H, 3.22; N, 14.17. Example 53 5-Chloro-1-(3,4-dichlorophenyl)-N-methyl lR-pyrazole-4-carboxamide, mp = 118 -120 C Analysis calculated for C11H8Cl3N3O Theory: C, 43.38; H, 2.65; N, 13.80; C1, 34.92; Found: C, 43.38; H, 2.81; N, 13.55; C1, 34.71. Example 54 -Chloro-1-(3,4-dichlorophenyl)-N,N-dimethyl lE-pyrazole-4-carboxamide, mp = 128 -130 C Analysis calculated for C12H10C13N3 0 Theory: C, 45.24; H, 3.16; N, 13.19; C1, 33.38; Found: C, 45.49; H, 3.43; N, 13.19; C1, 33.15. Example 55 5-Chloro-1-(4-bromophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1750-1770C Analysis calculated for C11H9BrClN3O Theory: C, 42.00; H, 2.88; N, 13.36; Cl, 11.27; Br, 25.40; Found: C, 42.06; H, 2.79; N, 13.11; Cl, 11.30; Br, 25.54. Example 56 5-Chloro-1-(4-bromophenyl)-N,N-dimethyl-1Hpyrazole-4-carboxamide, mp = 1110-1130C Analysis calculated for C12H11BrClN3O Theory: C, 43.86; H, 3.37; N, 12.79; Cl, 10.79; Br, 24.32; Found: C, 43.98; H, 3.20; N, 12.83; Cl, 11.03; Br, 24.60. Example 57 5-Chloro-1-(4-bromophenyl)-N-ethyl-1H-pyrazole-4-carboxamide, mp = 1700-1720C Analysis calculated for C12HllBrClN3O Theory: C, 43.86; H, 3.37; N, 12.79; C1, 10.79; Br, 24.32; Found: C, 44.04; H, 3.25; N, 13.03; C1, 10.66; Br, 24.12. Example 58 5-Bromo-1-(4-methylphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1600-1620C Analysis calculated for C12Hl2BrN3O Theory: C, 49.00; H, 4.11; N, 14.29; Found: C, 48.73; H, 4.17; N, 14.03. Example 59 5-Chloro-1-(4-methylphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1540-1560C Analysis calculated for C12H12ClN3O Theory: C, 57.72; H, 4.84; N, 16.83; Found: C, 57.94; H, 4.83; N, 16.59. Example 60 5-Chloro-1-(4-methylphenyl)-N,N-dimethyllH-pyrazole-4-carboxamide, mp = 84 -87 C Analysis calculated for C13H14ClN3O Theory: C, 59.21; H, 5.35; N, 15.93; Found: C, 59.44; H, 5.31; N, 16.13. Example 61 5-Methylthio-l-phenyl-N-methyl-lH-pyrazole- 4-carboxamide, mp = 108 -110 C Analysis calculated for C12Xl3N3OS Theory: C, 58.28; H, 5.30; N, 16.99; Found: C, 58.11; H, 5.44; Nr 16.78. Example 62 5-Bromo-l-(4-chlorophenyl)-N-methyl-1H- pyrazole-4-carboxamide, mp = 1710-1730C Analysis calculated for C11H9BrClN3O Theory: C, 42.00; H, 2.88; N, 13.36; C1, 11.27; Br, 25.40; Found: C, 41.85; H, 2.72; N, 13.49; Cl, 11.38; Br, 25.60. Example 63 5-Bromo-1-(4-chlorophenyl)-N,N-dimethyl-1Hpyrazole-4-carboxamide, mp = 1320-1340C Analysis calculated for C12H11BrClN3O Theory: C, 43.86; H, 3.37; N, 12.79; Cl, 10.79; Br, 24.32; Found: C, 43.64; H, 3.16; N, 12.50; Cl, 10.94; Br, 24.56. Example 64 5-Bromo-1-(4-methoxyphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 166 -167 C Analysis calculated for C12H12BrN3O2 Theory: C, 46.47; H, 3.90; N, 13.55; Found: C, 46.62; H, 3.88; N, 13.41. Example 65 5-Methoxy-1-(3-chlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1040-1050C Analysis calculated for C12H12ClN3O2 Theory: C, 54.25; H, 4.55; N, 15.82; -Found: C, 54.09; H, 4.39; N, 15.58. Example 66 5-Chloro-1-(4-chlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 161-163 C Analysis calculated for C11H9Cl2N3O Theory: C, 48.91; H, 3.36; N, 15.56; Cl, 26.25; Found: C, 48.99; H, 3.55; N, 15.68; C1, 26.46. Example 67 5-Chloro-1-(4-chlorophenyl)-N,N-dimethyl-1H pyrazole-4-carboxamide, mp = 119 -121 C Analysis calculated for C12HllCl2N3O Theory: C, 50.72; H, 3.90; N, 14.79; C1, 24.95; Found: C, 50.42; H, 3.92; N, 14.68; Cl, 25.22. Example 68 5-Chloro-1-(4-ethylphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 151 -153 C Analysis calculated for C13H14ClN3O Theory: C, 59.21; H, 5.35; N, 15.93; Found: C, 59.31; H, 5.19; N, 16.09. Example 69 5-Bromo-1-(4-ethylphenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1670-1680C Analysis calculated for C13Hl4BrN3O Theory: C, 50.67; H, 4.58; N, 13.64; Found: C, 50.86; H, 4.36; N, 13.39. Example 70 5-Chloro-1-(2,4-dichlorophenyl)-N-methyl lH-pyrazole-4-carboxamide, mp = 1530-1550C Analysis calculated for C11H8C13N30 Theory: C, 43.38; X, 2.65; N, 13.80; C1, 34.92; Found: C, 43.63; H, 2.55; N, 13.67; Cl, 35.11. Example 71 5-Bromo-1-(2,4-dichlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 153 -154 C Analysis calculated for C11H8BrCl2N3O Theory: C, 37.86; H, 2.31; N, 12.04; Found: C, 38.01; H, 2.18; N, 11.80. Example 72 5-Bromo-1-(2,4-dichlorophenyl)-N,N-dimethyl lH-pyrazole-4-carboxamide, mp = 880-900C Analysis calculated for C12H10BrC12N3 0 Theory: C, 39.70; H, 2.78; N, 11.57; Found: C, 39.49; H, 2.63; N, 11.33. Example 73 5-Bromo-1-(2,4-dichlorophenyl)-N-ethyl-1H pyrazole-4-carboxamide, mp = 135 -136 C Analysis calculated for 12H10BrCl2N3O Theory: C, 39.70; H, 2.78; N, 11.57; Found: C, 39.92; H, 2.70; N, 11.51. Example 74 5-Chloro-1-(2,3-dichlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 210 -213 C Analysis calculated for C11H8Cl3N3O Theory: C, 43.38; H, 2.65; N, 13.80; Found: C, 43.31; H, 2.61; N, 13.90. Example 75 5-Chloro-1-(2,4,6-trichlorophenyl)-Nmethyl-1H-pyrazole-4-carboxamide, mp = 1880-1900C Analysis calculated for C11H7Cl4N3O Theory: C, 38.97; H, 2.08; N, 12.40; Found: C, 39.24; H, 2.07; N, 12.68. Example 76 5-Chloro-1-(2,4-dibromophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1590-1610C Analysis calculated for C11H8Br2ClN3O Theory: C, 33.58; H, 2.05; N, 10.68; Found: C, 33.74; H, 2.27; N, 10.70. Example 77 5-Chloro-1-(2,4-difluorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1330-1350C Analysis calculated for C11H8ClF2N3O Theory: C, 48.64; H, 2.97; N, 15.47; Found: C, 48.55; H, 3.04; N, 15.29. Example 78 5-Chloro-l-(3-chloro-4-methylphenyl)-N- methyl-lH-pyrazole-4-carboxamide, mp = 103 -105 C Analysis calculated for C12H11Cl2N3O Theory: C, 50.72; H, 3.90; N, 14.79; Found: C, 50,87; H, 3.78; N, 14.64. Example 79 5-Bromo-1-(3-chloro-4-methylphenyl)-N-methyl lH-pyrazole-4-carboxamide, mp = 159 -160 C Analysis calculated for C12H11BrClN3 0 Theory: C, 43.86; H, 3.37; N, 12.79; Found: C, 44.07; X, 3.51; N, 12.51. Example 80 5-Bromo-1-(3,4-dichlorophenyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 149 -151 C Analysis calculated for C11H8BrCl2N3O Theory: C, 37.86; H, 2.31; N, 12.04; Found: C, 37.84; H, 2.17; N, 11.83. Example 81 5-Methoxy-1-[3-(trifluoromethyl)phenyl]-Nmethyl-lH-pyrazole-4-carboxamide, mp = 1280-1300C Analysis calculated for C13Hl2F3N302 Theory: C, 52.18; , 4.04; N, 14.04; Fcund: C, 52.41; H, 3.76; N, 13.83. Example 82 5-Bromo-1-(3-fluorophenyl)-N-cyclopropyl-1Hpyrazole-4-carboxamide, mp = 1440-1460C Analysis calculated for C13H11BrFN3O Theory: C, 48.17; H, 3.42; N, 12.96; Found: C, 47.96; H, 3.19; N, 12.68. Example 83 5-Bromo-1-(3,5-dichlorophenyl)-N-cyclo propyl-lH-pyrazole-4-carboxamide, mp = 1840-1850C Analysis calculated for C13H10BrCl2N3O Theory: C, 41.63; H, 2.69; N, 11.20; Found; C, 41.82; H, 2.79; N, 11.27. Example 84 5-Chloro-1-[3-(trifluoromethyl)phenyl]-Ncyclopropyl-lH-pyrazole-4-carboxamide, mp = 1210-1220C Analysis calculated for C14H11ClF3N3O Theory: C, 51.00; H, 3.36; N, 12.74; Found: C, 51.29; H, 3.33; N, 12.79. Example 85 5-Chloro-1-phenyl-N-cyclopropyl-1H-pyrazole4-carboxamide, mp = 154 -155 C Analysis calculated for C13H12C1N3 0 Theory: C, 59.66; H, 4.62; N, 16.06; Found: C, 59.91; H, 4.40; N, 16.29. Example 86 5-Bromo-1-(2,4-dichlorophenyl)-N-cyclopro pyl-1H-pyrazole-4-carboxamide, mp = 158 -159 C Analysis calculated for C13H10BrCl2N3O Theory: C, 41.63; H, 2.69; N, 11.20; Found: C, 41.67; H, 2.42; N, 11.42. Example 87 5-Chloro-1-(4-chlorophenyl)-N-cyclopropyl-1Hpyrazole-4-carboxamide, mp = 1860-1880C Analysis calculated for C13H11Cl2N3O Theory: C, 52.72; H, 3.74; N, 14.19; Found: C, 52.88; H, 3.89; N, 14.22. Example 88 5-Chloro-1-(2,4-difluoropehnyl)-N-cyclopropyl-1H-pyrazole-4-carboxamide, mp = 1410-1430C Analysis calculated for C13H10ClF2N3O Theory: C, 52.45; H, 3.39; N, 14.12; Found: C, 52.66; H, 3.19; N, 13.94. Example 89 5-Chloro-1-(3-chlorophenyl)-N-cyclopropyllH-pyrazole-4-carboxamide, mp = 1040-1060C Analysis calculated for C13H11Cl2N3O Theory: C, 52.72; H, 3.74; N, 14.19; Found: C, 52.91; H, 3.59; N, 14.23. Example 90 5-Chloro-1-(3-bromophenyl)-N-cyclopropyl-1Hpyrazole-4-carboxamide, mp = 1080C Analysis calculated for C13H11BrClN3O Theory: C, 45.84; H, 3.26; N, 12.34; Found: C, 46.09; H, 3.22; N, 12.18. Example 91 5-Chloro-1-(2,4-dichlorophenyl)-N-cyclopropyl-1H-pyrazole-4-carboxamide, mp = 158 -160 C Analysis calculated for C13H10Cl3N3O Theory: C, 47.23; H, 3.05; N, 12.71; Found: C, 47.13; H, 2.86; N, 12.63. Example 92 5-Chloro-1-(2-pyridinyl)-N-methyl-1Hpyrazole-4-carboxamide, mp = 1330-1350C Analysis calculated for C10H9ClN4O Theory: C, 50.75; H, 3.83; N, 23.67; Found: C, 50.71; H, 3.57; N, 23.45. Example 93 5-Chloro-1-(3,4-dimethylphenyl)-N-cyclo propyl-lH-pyrazole-4-carboxamide, mp = 142 -144 C Analysis calculated for C15Hl6ClN3O Theory: C, 62.18; H, 5.57; N, 14.50; Found: C, 61.88; H, 5.47; N, 14.46. Example 94 5-Chloro-1-methyl-N-cyclopropyl-1H-pyrazole4-carboxamide A. 5-Amino-1-methyl-1H-pyrazole-4-carboxylic acid, ethyl ester Nethylhydrazine (25 grams, 0.54 mole) and ethyl (ethoxymethylene)cyanoacetate (92 grams, 0.54 mole) were combined in 150 ml. of ethanol and refluxed for about 16 hours. The reaction mixture was then cooled and poured over ice water, and the resulting precipitated product was collected by filtration and dried. The mother liquor was extracted with chloroform, washed with saturated brine, and dried using sodium sulfate and filter paper. Solvent was removed in vacuo. Both groups of crystallized product were recrystallized from ethanol, yielding 32.3 grams (35%) of 5-aminb-l-methyl- 1H-pyrazole--carboxylic acid, ethyl ester, mp = 99 -100 C. B. 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid, ethyl ester For a period of 60 minutes, hydrogen chloride gas was bubbled into a solution of 5-amino-1-methyl- IH-pyrazole-4-carboxylic acid, ethyl ester (12 grams, 0.07 mole) in 75 ml. of chloroform. The reaction mixture set up and nitrosyl chloride was bubbled into the reaction mixture for a period of five minutes. TLC indicated that starting material was still present, therefore, nitrosyl chloride was bubbled into the reac tion mixture for an additional five minutes. The solution was heated on a steam bath for five minutes, then cooled and the solvent removed in vacuo, yielding 5chloro-l-methyl-lH-pyrazole-4-carboxylic acid, ethyl ester. The identity of the product was confirmed by NMR. C. 5-Chloro-l-methyl-lH-pyrazole-4-carboxylic acid 5-Chloro-l-methyl-lH-pyrazole-4-carboxylic acid, ethyl ester (13 grams, 0.07 mole) and potassium hydroxide (7.8 grams, 0.14 mole) were combined in 75 ml. of ethanol and refluxed for six hours. The solution was cooled, poured over water, acidified with concentrated hydrochloric acid, and the precipitated solid collected, dried, and recrystallized from water. The resulting 5-chloro-l-methyl-lH-pyrazole-4-carboxylic acid was obtained in the amount of 5.4 grams and melted at l950-1970C. Analysis calculated for C5H5C1N202 Theory: C, 37.53; H, 3.15; N, 17.15; Found: C, 37.68; H, 3.06; N, 17.69. D. 5-Chloro-l-methyl-N-cyclopropyl-lH- pyrazole-4-carboxamide Carbonyldiimidazole (3.6 grams, 0.022 mol) was added to a solution of 5-chloro-1-methyl-lH-pyra zole-4-carboxylic acid (2.4 grams, 0.015 mole) in 40 ml. of tetrahydrofuran, and the solution was stirred at room temperature for twenty minutes. Cyclopropylamine (1.3 grams, 0.022 mole) was then added and the reaction mixture was stirred at room temperature for sixteen hours. Solvent was removed in vacuo and the residue was taken up in 250 ml. of chloroform, washed with water, washed with saturated brine, and dried using sodium sulfate and filter paper. The product was recrystallized from toluene, yielding 3.5 grams of S-chloro-1- methyl-N-cyclopropyl-lH-pyrazole-4-carboxamide, mp = 105 -107 C. Analysis calculated for C8H10ClN3O Theory: C, 48.13; H, 5.05; N, 21.05; Found: C, 48.38; H, 5.01; N, 20.90. The following¯other 1-alkyl compounds of the present invention were prepared in the same procedures as reported in Example 94. Example 95 5-Bromo-1-tert-butyl-N-methyl-1H-pyrazole-4carboxamide, mp = 1280-1300C Analysis calculated for CgH14BrN3O Theory: C, 41.57; H, 5.43; N, 16.16; Found: C, 41.67; H, 5.49; N, 16.14. Example 96 5-Bromo-1-tert-butyl-N,N-dimethyl-1H-pyrazole4-carboxamide, mp = 870-900C Analysis calculated for C10H16BrN3O Theory: C, 43.81; H, 5.88; N, 15.33; Found: C, 43.76; H, 5.71; N, 15.56. Example 97 5-Bromo-1-tert-butyl-N-cyclopropyl-1H-pyra zole-4-carboxamide, mp = 1480-1500C Analysis calculated for C11H16BrN30 Theory: C, 46.17; H, 5.64; N, 14.68; Found; -C, 45.96; H, 5.63; N, 14.45. ample 98 5-Bromo-1-tert-butyl-N-ethyl-1H-pyrazole-4 carboxamide, mp = 930-950C Analysis calculated for C10H16BrN3O Theory: C, 43.81; H, 5.88; N, 15.33; Found: C, 43.94; H, 5.87; N, 15.17. Example 99 5-Bromo-1-tert-butyl-N-isopropyl-lH-pyrazole4-carboxamide, mp 1080-1100C Analysis calculated for C11H18BrN3O Theory: C, 45.85; H, 6.30; N, 14.58; Found: C, 46.13; H, 6.65; N, 14.63. Example 100 5-Bromo-1-tert-butyl-N-methyl-N-ethyl-1Hpyrazole-4-carboxamide, mp = 980-1000C Analysis calculated for C11H18BrN3O Theory: C, 45.85; H, 6.30; N, 14.58; Found: C, 45.85; H, 6.43; N, 14.56. Example 101 5-Bromo-1-tert-butyl-N-methyl-N-methoxy-1Hpyrazole-4-carboxamide, mp = 710-740C Analysis calculated for C10H16BrN3O2 Theory: C, 41.39; H, 5.56; N, 14.48; Found: C, 41.62; H, 5.66; N, 14.71. Example 102 5-Chloro-1-tert-butyl-N-methyl-1H-pyrazole-4carboxamide, mp = 154 -156 C Analysis calculated for C9H14C1N3 0 Theory: C, 50.12; H, 6.54; N, 19.48; Found: C, 50.10; H, 6.36; N, 19.45. Example 103 5-Chloro-l-tert-butyl-N-cyclopropyl-lH-pyrazole-4-carboxamide, mp = 1680-1710C Analysis calculated for C11H16ClN3O Theory: C, 54.64; H, 6.67; N, 17.38; Found: C, 54.84; H, 6.92; N, 17.35. Example 104 5-Chloro-1-tert-butyl-N,N-dimethyl-1H-pyrazole-4-carboxamide, oil Analysis calculated for C10H16ClN3O Theory: C, 52.29; H, 7.02; N, 18.29; Found; C, 52.53; H, 7.12; N, 18.40. Example 105 5-Chloro-1-tert-butyl-N-methyl-N-methoxy-1Hpyrazole-4-carboxamide, oil Analysis calculated for C10H16C1N3 02 Theory: C, 48.88; H, 6.56; N, 17.10; Found: C, 48.66; H, 6.61; N, 17.26. Example 106 5-Chloro-1-tert-butyl-N-ethyl-1H-pyrazole-4carboxamide, mp = 1090-1100C Analysis calculated for C10H16ClN3O Theory: C, 52.29; H, 7.02; N, 18.29; Found: C, 52.44; H, 7.22; N, 18.38. Example 107 5-Chloro-1-tert-butyl-N-methyl-N-ethyl-1Hpyrazole-4-carboxamide, mp = 710-730C Analysis calculated for C11H18ClN3O Theory: C, 54.37; H, 7.47; N, 17.29; Found: C, 54.02; H, 7.65; N, 17.01. Example 108 5-Chloro-1-tert-butyl-N,N-diethyl-1H-pyrazole4-carboxamide, oil Analysis calculated for-C12H20ClN30 Theory: C, 55.92; H, 7.82; N, 16.30; Found: C, 55.79; H, 7.66; N, 16.53. Example 109 5-(Trifluoromethyl)-1-(2,4-dichlorophenyl) N-methyl-lH-pyrazole-4-carboxamide A. 5-(Trifluoromethyl)-1-(2,4-dichlorophenyl)lH-pyrazole-4-carboxylic acid, ethyl ester 2,-Dichlorophenylhydrazine hydrochloride salt (15.68 grams, 0.068 mole) was dissolved in a minumum amount of ethanol and the solution was cooled to -100C. Triethylamine (9.44 ml., 0.068 mole) was added followed by ethyl (ethoxymethylene)trifluoroacetoacetate (16.27 grams, 0.068 mole). The addition of this last reactant was made over thirty minutes, keeping the reaction temperature below -100C. The reaction mixture was allowed to rise to room temperature overnight (about 16 hours). The solvent was removed in vacuo and the residue was dissolved in equal parts of ethyl acetate and water. The organic phase was separated, washed with 1N HC1, water, saturated sodium bicarbonate solution, water, and brine. It was then dried and evaporated to 7.85 grams of an oil which slowly crystallized. The s-(trifluoromethyl)-1-(2,4-dichlorophenyl)-lE-pyrazole- 4-carboxylic acid, ethyl ester, was recrystallized from petroleum ether, mp = 81 -83 C. B. S-(Trifluoromethyl)-1-(2,4-dichlorophenyl )- lH-pyrazole-4-carboxylic acid 5-(Trifluoromethyl)-1-(2,4-dichlorophenyl)- IH-pyrazole-4-carboxylic acid ethyl ester (3.31 grams, 0.0094 mole) and potassium hydroxide (0.8 gram, 0.014 mole) were combined in 25 ml. of ethanol. The reaction mixture was refluxed for 2 hours, then poured into 150 ml. of ice/water and filtered to remove solids. The remaining solution was acidified with concentrated HCl, filtered to separate the precipitate which was then dried and recrystallized from cyclohexane/toluene with charcoal, yielding 1.90 grams of 5-(trifluoromethyl) 1-(2,4-dichlorophe-nyl)-lH-pyrazole-4-carboxylic acid, mp = 1540-1550C. Analysis calculated for C11H5C12F3N202 Theory: C, 40.64; H, 1.55; N, 8.62; Found: C,- 40.85; H, 1.79; N, 8.41. C. 5-(Trifluoromethyl)-1-(2,4-dichloro- phenyl)-N-methyl-1H-pyrazole-4-carboxamide 5-(Trifluoromethyl)-1-(2,4-dichlorophenyl) lH-pyrazole-4-carboxylic acid (1.50 grams, 0.0046 mole) and carbonyldiimidazole (0.94 gram, 0.0058 mole) were dissolved in DMF. The reaction mixture was stirred for 10 minutes, then 7 ml. of 40% aqueous methylamine were added. The reaction mixture was stirred for three hours at room temperature, then poured into 150 ml. of water and filtered. The precipitate was dried to 1.51 grams, then recrystallized from 10:1 cyclohexane/toluene, yielding 1.23 grams of 5-(trifluoromethyl)-1-(2,4dichlorophenyl)-N-methyl-1H-pyrazole-4-carboxamide, mp = 1430-1440C. Analysis calculated for C12H8C12F3N3 0 Theory: C, 42.63; H, 2.38; N, 12.43; Found: C, 42.63; H, 2.44; N, 12.21. The following other 5-(trifluoromethyl) compounds of the present invention were prepared in the same procedures as in Example 109. Example 110 5-(Trifluoromethyl)-1-(2,4-dichlorophenyl)-N cyclopropyl-lH-pyrazole-4-carboxamide, mp = 1320-1330C Analysis calculated for C14H10Cl2F3N3O Theory: C, 46.18; H, 2.77; N, 11.54; Found C, 46.13; H, 2.99; N, 11.29. Example 111 5-(Trifluoromethyl)-1-(2,4-dichlorophenyl) N,N-dimethyl-lH-pyrazole-4-carboxamide, mp = 1200-1220C Analysis calculated for C13H10Cl2F3N3C Theory: C, 44.34; H, 2.86; N, 11.93; Found: C, 44.17; H, 2.66; N, 11.96. Example 112 5-(Trifluoromethyl)-1-(4-chlorophenyl)-Nmethyl-lH-pyrazole-4-carboxamide, mp = 1560-1570C Analysis calculated for C12H9ClF3N3O Theory: C, 47.46; H, 2.99; N, 13.84; Found: C, 47.42; H, 3.09; N, 13.76. Example 113 5-(Trifluoromethyl)-1-(4-chlorophenyl)-N cyclopropyl-1H-pyrazole-4-carboxamide, mp = 1640-1650C Analysis calculated for C14H11C1F3N3 0 Theory: C, 51.00; H, 3.36; N, 12.74; Found: C, 51.20; H, 3.11; N, 12.69. Example 114 5-(Trifluoromethyl)-1-(4-chlorophenyl)-N,Ndimethyl-lH-pyrazole-4-carboxamide, mp = 117 -119 C Analysis calculated for C13H11ClF3N3O Theory: C,. 49.15; H, 3;49; N, 13.23; Found: C, 48.98; H, 3.70; N, 13.10. Example 115 5-(Trifluoromethyl)-1-(4-chlorophenyl)-N ethyl-lH-pyrazole-4-carboxamide, mp = 131 -133 C Analysis calculated for C13H11ClF3N3O Theory: C, 49.15; H, 3.49; N, 13.23; Found: C, 48.96; H, 3.23; N, 13.16. Example 116 5-(Trifluoromethyl)-1-(4-chlorophenyl)-N,N diethyl-1H-pyrazole-4-carboxamide, mp = 66 -67 C Analysis calculated for C15H15C1F3N3 0 Theory: C, 52.11; H, 4.37; N, 12.15; Found: C, 52.37; H, 4.36; N, 12.18. Example 117 5-(Trifluoromethyl)-1-(4-chlorophenyl)-Nmethyl-N-methoxy-1H-pyrazole-4-carboxamide, mp = 76 -78 C Analysis calculated for C13H11ClF3N3O2 Theory: C, 46.79; H, 3.32; N, 12.59; Found: C, 46.82; H, 3.09; N, 12 60. Example 118 5-(Trifluoromethyl)-1-phenyl-N-methyl-1Hpyrazole-4-carboxamide, mp = 152 -154 C Analysis calculated for C12H10F3N3O Theory: C, 53.54; H, 3.74; N, 15.61; Found: C, 53.71; H, 3.65; N, 15.84. Example 119 5-(Trifluoromethyl)-1-phenyl-N-cyclopropyl-1H pyrazole-4-carboxamide, mp = l350-1380C Analysis calculated for C14H12F3N30 Theory: C, 56.95; H, 4.10; N, 14.23; Found: C, 56.66; H, 4.14; N, 14.25. Example 120 5-(Trifluoromethyl)-1-phenyl-N-isopropyl-1Hpyrazole-4-carboxamide, mp = 136 -137 C Analysis calculated for C14H14F3N3 0 Theory: C, 56.56; H, 4.75; N, 14.13; Found: C, 56.79; H, 4.53; N, 14.32. Example 121 5-(Trifluoromethyl)-1-phenyl-N-methyl-N-ethyllH-pyrazole-4-carboxamide Analysis calculated for C14H14F3N3 0 Theory: C, 56.56; H, 4.75; N, 14.13; Found: C, 56.33; H, 4.63; N, 14.06. Example 122 5-(Trifluoromethyl)-1-phenyl-N,N-dimethyl-1Hpyrazole-4-carboxamide, mp = 102 -104 C Analysis calculated for C13H12F3N3O Theory: C, 55.13; H, 4.27; N, 14.83; Found: C, 55.07; H, 4.49; N, 14.91. Example 123 5-(Trifluoromethyl)-1-phenyl-N-ethyl-1Hpyrazole-4-carboxamide, mp = 117 -118 C Analysis calculated for C13H12F3N3 0 Theory: C, 55.13; H, 4.27; N, 14.83; Found: C, 55.00; H, 4.10; N, 14.68. Example 124 5-(Trifluoromethyl)-1-phenyl-N-propyl-1Hpyrazole-4-carboxamide, mp = 800-810C Analysis calculated for C14H14F3N3O Theory: C, 56.56; H, 4.75; N, 1fl.13; Found: C, 56.33; H, 4.90; N, 13.86. Example 125 5-(Trifluoromethyl)-1-phenyl-N-butyl-1Hpyrazole-4-carboxamide, mp = 730-750C Analysis calculated for C15Hl6F3N3O Theory: C, 57.87; H, 5.18; N, 13.50; Found: C, 58.06; H, 5.17; N, 13.60. Example 126 5-(Trifluoromethyl)-1-phenyl-N-methyl-Nmethoxy-1H-pyrazole-4-carboxamide, mp= 49 -51 C Analysis calculated for C13H12F3N3 02 Theory: C, 52.18; H, 4.04; N, 14.04; Found: C, 52.40; H, 3.79; H, 14.13. Example 127 5-(Trifluoromethyl)-1-phenyl-1H-pyrazole-4carboxamide, mp = 1790-1800C Analysis calculated for C11H8F3N3 0 Theory: C, 51.77; H, 3.16; N, 16.47; Found: C, 51.54; H, 3.31; N, 16.37. Example 128 5-(Trifluoromethyl)-1-phenyl-N,N-diethyl-1Hpyrazole-4-carboxamide, oil Analysis calculated for C15H16F3N3 0 Theory: C, 57.87; B, 5.18; N, 13.50; Found: C, 57.63; H, 5.20; N, 13.49. Example 129 5-(Trifluoromethyl)-1-phenyl-N,N-dipropyl-1Hpyrazole-4-carboxamide, mp = 960-980C Analysis calculated for C17H20F- N3 0 Theory: C, 60.17; H, 5.94; N, 12.38; Found: C, 59.89; H, 5.69; N, 12.64. Example 130 5-(Trifluoromethyl)-1-(3-chlorophenyl)-Nmethyl-1H-pyrazole-4-carboxamide, mp = 1140C Analysis calculated for C12H9ClF3N3O Theory: C, 47.46; H, 2.99; N, 13.84; Found: C, 47.35; H, 2.74; N, 13.81. Example 131 5-(Trifluoromethyl)-1-(3-chlorophenyl)-Ncyclopropyl-1H-pyrazole-4-carboxamide, mp = 99 -100 C Analysis calculated for C14H11ClF3N3O Theory: C, 51.00; H, 3.36; N, 12.74; Found: C, 50.90; H, 3.28; N, 12.58. Example 132 5-(Trifluoromethyl)-1-(3-chlorophenyl)-N ethyl-lH-pyrazole-4-carboxamide, mp = 87 -89 C Analysis calculated for C13H11ClF3N3O Theory: C, 49.15; H, 3.49; N, 13,23 Found: C, 49.26; H, 3.25; N, 13.16. Example-133 5-(Trifluoromethyl)-1-(3-chlorophenyl)-N,Ndiethyl-1H-pyrazole-4-carboxamide, oil Analysis calculated for C15H15ClF3N3O Theory: C, 52.11; H, 4.37; N, 12.15; Found: C, 51.91; H, 4.53; N, 11.88. Example 134 5- (Trifluoromethyl ) -1- (3-chlorophenyl ) -Nmethyl-N-methoxy-1H-pyrazole-4-carboxamide, oil Analysis calculated for C13H11C 1F3N30 Theory: C, 46.79; H, 3.32; N, 12.59; Found: C, 46.55; H, 3.33; N, 12.37. Example 135 5-(Trifluoromethyl)-1-(4-methoxyphenyl)-Nmethyl-1H-pyrazole-4-carboxamide Analysis calculated for C13H12F3N3O2 Theory: C, 52.18; H, 4.04; N, 14.04; Found: C, 52.05; H, 3.77; N, 13.95. Example 136 5-(Trifluoromethyl)-1-(4-methoxyphenyl)-N cyclopropyl-1H-pyrazole-4-carboxamide, mp = 156 -158 C Analysis calculated for C15H14F3N302 Theory: C, 55.39; H, 4.34; N, 12.92; Found: C, 55.35; H, 4.24; N, 13.03. Example 137 5-(Trifluoromethyl)-1-(4-methoxyphenyl)-Nethyl-1H-pyrazole-4-carboxamide, mp = 1510-1520C Analysis calculated for C14Hl4F3N3O2 Theory: C, 53.68; H, 4.50; N, 13.41; Found: C, 53.69; H, 4.76; N, 13.48. Example 138 5-(Trifluoromethyl)-1-(4-methoxyphenyl) N,N-dimethyl-lH-pyrazole-4-carboxamide, mp = 1360C Analysis calculated for C14H14F3N3O2 Theory: C, 53.68; H, 4.50;.N, 13.41; Found: C, 53.45; H, 4.74; N, 13.33. Example 139 5-(Trifluoromethyl)-1-(4-methoxyphenyl)-Nmethyl-N-methoxy-1H-pyrazole-4-carboxamide, mp = 54 -56 C Analysis calculated for C14H14F3N3O3 Theory: C, 51.07; H, 4.27; N, 12.76; Found: C, 51.21; H, 4.46; N, 13.92. Example 140 5-(Trifluoromethyl)-1-(4-methylphenyl)-Nmethyl-1H-pyrazole-4-carboxamide, mp = 180 -182 C Analysis calculated for C13H12F3N3O Theory: C, 55.13; H, 4.27; N, 14.83; Found: C, 55.28; H, 4.11; N, 14.66. Example 141 5-(Trifluoromethyl)-1-(4-methylphenyl)-Ncyclopropyl-lH-pyrazole-4-carboxamide, mp = 165 -167 C Analysis calculated for C15H14F3N3O Theory: C, 58.25; H, 4.56; N, 13.59; Found: C, 58.52; H, 4.47; N, 13.78. Example 142 5-(Trifluoromethyl)-1-(4-methylphenyl)-Nethyl-1H-pyrazole-4-carboxamide, mp = 1440-1450C Analysis calculated for C14H14F3N3O Theory: C, 56.56; H, 4.75; N, 14.13; Found: C, 56.78; H, 4.87; N, 14.09. Example 143 5-(Trifluoromethyl)-1-(4-methylphenyl)-N,Ndiethyl-1H-pyrazole-4-carboxamide, mp = 750-760C Analysis calculated for C16H18F3N30 Theory: C, 59.07; H, 5.58; N, 12.92; Found: C, 59.34; H, 5.74; N, 12.84. Example 144 5-(Trifluoromethyl)-1-(4-methylphenyl)-Nmethyl-N-methoxy-lH-pyrazole-4-carboxamide, mp = 66 -68 C Analysis calculated for C14H14F3N3 02 Theory: C, 53.68; H, 4.50; N, 13.41; Found: C, 53.95; H, 4.34; N, 13.70. Example 145 5-(Trifluoromethyl)-1-(3-(trifluoromethyl) phenyl )-N-methyl-lH-pyrazole-4-carboxamide, mp = 123 -124 C Analysis calculated for C13119F6N3 0 Theory: C, 46.30; H, 2.69; N, 12.46; Found: C, 46.31; H, 2.76; N, 12.32. Example 146 5-(Trifluoromethyl)-1-(3-(trifluoromethyl)phenyl)-N-cyclopropyl-1H-pyrazole-4-carboxamide, mp = 1010-1020C Analysis calculated for C15H11F6N3 0 Theory: C, 49.60; H, 3.05; N, 11.57; Found : C, 49.69; H, 3.23; N, 11.45. Example 147 5-(Trifluoromethyl)-1-(3-(trifluoromethyl)phenyl)-N,N-diethyl-1H-pyrazole-4-carboxamide, mp = 86 C Analysis calculated for C16H15F6N3 0 Theory: C, 50.67; H, 3.99; N, 11.08; Found : C, 50.66; H, 4.18; N, 10.92. Example 148 5-(Trifluoromethyl)-1-(3-trifluoromethyl)phenyl)-N-methyl-N-methoxy-1H-pyrazole-4-carboxamide, mp = 560-570C Analysis calculated for C14H11F6N3O2 Theory: C, 45.79; H, 3.02; N, 11.44; Found: C, 46.05; H, 3.27; N, 11.45. Example 149 5-(Trifluoromethyl)-1-(2-pyridinyl)-N-methyl- 1R-pyrazole-4-carboxamide, mp = 140.50-1420C Analysis calculated for C11H9F3N4O Theory: C, 48.90; H, 3.36; N, 20.73; Found: C, 48.98; H, 3.42; N, 20.56. Example 150 5-(Trifluoromethyl)-1-(2-pyridinyl)-N-cyclo propyl-lH-pyrazole-4-carboxamide, mp = 118 -119 C Analysis calculated for C13H11F3N4O Theory: C, 52.71; H, 3.74; N, 18.91; Found: C, 52.60; H, 3.45; N, 18.88. Example 151 5-(Trifluoromethyl)-1-(2-pyridinyl)-N,N-dimethyllH-pyrazole-4-carboxamide, mp = 770-790C Analysis calculated for C12H11F3N4O Theory: C, 50.71; H, 3.90; N, 19.71; Found: C, 50.74; H, 3.96; N, 19.44. Example 152 5-(Trifluoromethyl)-1-(2,4,6-trichlorophenyl) N-methyl-lH-pyrazole-4-carboxamide, mp = 197 -198 C Analysis calculated for C12H7Cl3F3N3O Theory: C, 38,69; H, 1.89; N, 11.28; Found: C, 38.89; H, 2.00; N, 11.26. Example 153 5-(Trifluoromethyl)-1-(2,4,6-trichlorophenyl) N-cyclopropyl-1H-pyrazole-4-carboxamide, mp = 199 -201 C Analysis calculated for C14H9C13F3N30 Theory: C, 42.19; H, 2.28; N, 10.54; Found: C, 42.07; H, 2.36; N, 10.78. Example 154 5-(Trifluoromethyl)-1-(2,4,6-trichlorophenyl) N,N-dimethyl-lH-pyrazole-4-carboxamide, mp = 119 -120 C Analysis calculated for C13H9C13F3N3 0 Theory: C, 40.39; H, 2.35; N, 10.87; Found: C, 40.55; H, 2.14; N, 10.77. Example 155 5-(Trifluoromethyl)-1-(2,4,6-trichlorophenyl)- N-ethyl-lH-pyrazole-4-carboxamide, mp = 1790-1810C Analysis calculated for C13H9Cl3F3N3O Theory: C, 40.39; H, 2.35; N, 10.87; Found: C, 40.47; H, 2.55; N, 10.79 Example 156 5-(Trifluoromethyl)-1-tert-butyl-N-methyl1H-pyrazole-4-carboxamide, mp = 780-790C Analysis calculated for C10H14F3N3O Theory: C, 48.19; H, 5.66; N, 16.86; Found: C, 48.12; H, 5.38; N, 16.84. Example 157 5-(Trifluoromethyl)-l-tert-butyl-N-cyclopropyl- lH-pyrazole-4-carboxamide, mp = 880-900C Analysis calculated for C12Hl6F3N3O Theory: C, 52.36; H, 5.86; N, 15.26; Found: C, 52.24; H, 6.08; N, 15.27. The compounds of the present invention are useful both as preemergent and postemergent herbicides. Therefore, yet another embodiment of the invention is a method for controlling undesired plants which comprises applying to the plants, or to the locus of the plants, a growth inhibiting amount of a present pyrazole derivative. The compounds of the present invention display activity against a wide variety of weeds. Examples of typical weeds include, but are not limited to, the following: Wild Oat (Avena fatua) Catchweed Bedstraw (Galium aparine) Scentless Mayweed (Matricaria incdora) Ladysthumb (Polyqonum persicaria) Common Chickweed (Stellaria media) Ivyleaf Speedwell (Veronica hederaefolia) Blackgrass (Alooecurus myosuroides) Chrysanthemum (Chrysanthenum spp.) Common Purslane (Portulaca oleracea) Sida (Sida spp.) Bristly Starbur (Acanthospermum hispidum) Goosegrass (Eleusine indica) Smooth Pigweed (Amaranthus hybridus) Alexandergrass (Brachiaria plantaginea) Tall Morningglory (Ipomoea purpurea) Common Lambsquarters <RTI ID=68.8> (Chenopodium album) Green Smartweed (Polvgonum scabrum) Green Foxtail (Setaria viridis) Redroot Pigweed (Amaranthus retroflexus) Wild Buckwheat (Polygonum convolvulus) Brazil Calalilly (Richardia brasiliensis) Natal Grass (Rhynchelytrum roseum) Ryegrass (Lolium rigidum) Kapeweed (Cryptostemma calendula) Purple Loosestrife (Lythrum salicaria) Wild radish (Raphanus raphanistrum) Wireweed (Polygonum aviculare) Renbit (Lamium amplexicaule) Wild Mustard (Brassica kaber) Barnyardgrass (Echinochloa crus-galli) Foxtail Millet (Setaria italica) Velvetleaf (Abutilon theophrasti) Indian Mustard (Brassicn juncea) Birdseye Speedwell (Veronica persica) Canada Thistle (Cirsium arvense) Wild Chamomile (Matricaria chamomilla) Annual Bluegrass (Poa annua) Buttercup (Ranunclulus spp.) Field Speedwell (Veronica agrestis) Field Violet (Viola arvensis) Field Pennycress (Thlaspi arvense) Wild Violet (Viola tricolor) Shirley Poppy (Papaver rhoeas) Field Poppy (Papaver dubium) Foolsparsley (Aethusa cynapium) Field Chickweed (Cerastium arvense) Southern Sanbur (Cenchrus echinatus) Large Crabgrass (Digitaria sanquinalis) Cheat (Bromus secalinus) Morningglory (Ipomea spp.) Common Ragweed (Ambrosia artemisiifolia) Common Milkweed (Asclepias syriaca) Giant Foxtail (Setaria faberi) Common Cocklebur (Xanthium pensylvanicum) Spurred Anoda (Anoda cristata) Sicklepod (Cassia obtusifolia) Yellow Nutsedge (Cyperus esculentus) Jimsonweed (Datura s$ramonium) Large Crabgrass (Digitaria sancuinalis3 Prickly Sida (Sida spinosa) Corn Gromwell (Lithoscermum arvense) Yellow Foxtail (Setaria glauca) Tansymustard (Descurainia pinnata) Pepperweed (Lepidium spp.) Bromegrass (Bromus spp.) Garden Spurge (Euphorbia hirta) Crowfootgrass (Dactyloctenium aegyptium) Florida Beggarweed (Desmodium tortuosum) Spotted Spurge (Euphorbia maculata) Smallflower Morningglory (Jacquemontia) tamnifolia) Browntop Millet (Panicum ramosum) Coast Fiddleneck (Amsinckia intermedia) Wild Turnip (Brassica campestris) Black Mustard (Brassica nigra) Shepherdspurse (Capsella bursa-pastoris) Italian Ryegrass (Lolium multirlorum) London Rocket (Sisymbrium irio) Redmaids Rockpurslane (Calandrinia caulescens) Common Groundsel (Senecio vulgaris) Ivyleaf Morningglory (Ipomoea hederacea) Fall Panicum (Panicum dichotomiflorum) Powell Amaranth (Amaranthus powellii) Texas Panicum (Panicum texanum) Hemp Sesbania (Sesbania exaltata) Annual Sowthistle (Sonchus oleraceus) Field Bindweed (Convolvulus arvensis) Erect Knotweed (Polygonum erectum) Venice Mallow (Hibiscus trionum) Zinnia (Zinnia elegens) Nightshade (Solanum spp.) The present compounds have also been found safe on a wide variety of desirable plant species, thereby exhibiting their unique selective capacity. Representative examples of relatively tolerant plant species, depending on the concentration of active agent employed, include the following: Corn (Zea mays) Wheat (Triticum aestivum) Soybean (Glycine max) Rice (Oryza sativa) Barley (Hordeum vulgare) Cotton (Gossypium hirsutum) Sorghum (Sorghum vulaare v. saccharatum) Sugarcane (Saccharum officinarum) Peanut (Arachis hypogaea) Pea (Pisum sativum) Alfalfa (Medicago sativa) Cucumber (Cucumis sativus) Tomato (Lycopersicon esculentum) Sugar beet (Beta vulgaris) Cabbage (Brassica oleracea capitata) The term "growth inhibiting amount", as defined herein, refers to an amount of a compound of the invention which either kills or stunts the growth of the weed species for which control is desired. This amount will generally be from about 0.05 to about 20.0 pounds or greater of a compound of the invention per acre (about 0.056 to about 22.4 kg/ha). The compounds are more preferably applied at rates of about 0.10 to about 8.0 pounds per acre (about 0.112 td about 8.96 kg/ha). The exact concentration of active ingredient required varies with the weed species to be controlled, type of formulation, soil type, climate conditions and the like. The term "undesired plants", as defined herein, refers to both weeds and weed seeds which are present at the location to be treated with a compound of the invention. These compounds can be applied to the soil to selectively control undesired plants by soil contact when the weed seeds are germinating and emerging. They can also be used -directly to kill emerged weeds by direct contact with the exposed portion of the weed. The compounds of the present invention are preferably formulated with a suitable agriculturallyacceptable carrier for ease of application. Such compositions will contain from about 0.1 to about 95.0 percent by weight of the active ingredient, depending on the composition Åaesi¯ed Examples of typical herbicidal compositions contemplated as another aspect of the present invention include sprayable rormulations, such as wettable powders, aqueous suspensions and emulsifiable concentrates, and solid compositions, such as dusts and granules. The most convenient formulations are in the form of concentrated compositions to be applied by spraying as water dispersions or emulsions containing in the range from about 0.1 percent to about 10 percent of the active agent by weight. Water-dispersible or emulsifiable compositions may be either solids, usually known as wettable powders, or liquids, usually known as emulsifiable concentrates and aqueous suspensions. A typical wettable powder comprises an intimate mixture of an active ingredient of the invention, an inert carrier, and surfactants. The concentration of the active agent is usually from about 25 percent to about 9.0 percent by weight. The inert carrier is usually chosen from among the attapulgite clays, the montmorillonite- clays, the diatomaceous earths, or the purified silicates. Effective surfactants, comprising from about 0.5 percent to about 10 percent by weight of the wettable powder, are chosen from among the sulfonated lignins, the condensed naphthalenesulfonates, and the alkyl sulfates. A typical emulsifiable concentrate comprises from about 0.1 to about 6 pounds of a compound of the invention per gallon of liquid (about 0.112 to about 6.72 kg), dissolved in a mixture of organic solvents and emulsifiers. The organic solvent is chosen with regard to its solvency and its cost. Useful sol vents include the aromatics, especially the xylenes and the heavy aromatic naphthas. wydrophilic cosolvents such as cyclohexanone and the glycol ethers such as 2-methoxyethanol may be included. Other organic solvents may also be used, including the terpenic solvents and kerosene. Suitable emulsifiers for emulsifiable concentrates are chosen from the alkylbenzenesulfonates, naphthalenesulfonates, and nonionic surfactants such as alkylphenol adduces of polyoxyethylene, and are used at similar percentages as for wettable powders. An aqueous suspension, or flowable, is comprised of a finely ground suspension of the active ingredient dispersed in a water based system. This type of formulation is particularly useful for compounds with low water solubility. The concentration of active agent is usually from about 15 to 60 percent by weight. A typical aqueous suspension may comprise wetting and dispersing agents, antifreeze components, thickening or bulking agents, as well as water and the active ingredient. Dust compositions containing a compound of the present invention usually contain from about 0.1 to about 10 percent by weight of the compound. Dusts are prepared by intimately mixing and finely grinding the active agent with an inert solid such as ground mont morillonite clay, attapulgite clay, talc, ground vol canic rock, keolin clay, or other invert, relatively dense, inexpensive substances. Solid, granular compositions are convenient for the application of compounds of this invention to the soil and will contain the active agent in an amount from about 0.1 to about 20 percent by weight. Granules comprise a compound of the invention dispersed on a granular inert carrier such as coarsely ground clay of from about 0.1 to about 3 mm particle size. The active ingredient is most conveniently applied to the clay by dissolving it in an inexpensive solvent, such as acetone, and applying the solution to the sized clay in an appropriate solids mixer. The solvent ns then typically removed by evaporation prior to applying the granules to the application site. When operating in accordance with the present invention, the present compounds or compositions thereof, maybe applied to the site where herbicidal or algicidal control is desired by any convenient manner, e.g., by means of hand dusters or sprayers. Metering applicators'can apply accurately measured quantities of granular compositions to the locus to be treated. Other applications can be carried out with power dusters, boom sprayers, high-pressure sprayers and spray dusters.- In large scale operations, dusts or lowvolume sprays can be applied aerially, for example from airplanes or helicopters, to the application site. When applying the formulations described above, it is important to apply the desired concentration of active ingredient uniformly to the plants or locus to be treated. The performance of the compounds of the present invention suggests that their preferred utilization will be as herbicides on grass crops, especially wheat, corn, and possibly sorghum. The compounds exhibit activity against both grass and broadleaf weed species, but exhibit greater activity against broadleaf species. The preferred application time is preemergent, that is, following planting of the crop but prior to its emergence. The following examples provide an illustration of typical agriculturally-acceptable compositions comprehended by this invention. Wettable Powder Concentration by Ingredient Weight (Percent) 5-Chloro-1-(2,4-dichlorophenyl)- 50.0 N-methyl-1E-pyrazole-4-carboxamide Igepal, a nonionic wetting agent, 5.0 GAF Corporation Polyfon 0, lignosulfonate dispersant, 5.0 Westvaco Corporation Zeolex 7, a precipitated hydrated 5.0 silica bulking agent, J.M. Huber Corporation Barden Clay, a kaolinite clay, J.M. 35.0 Huber Corporation 100.0 The ingredients are combined and finely ground to provide a free-flowing powder that can be suspended in water for convenient spray application. Aqueous Suspension Concentration by Ingredient Weight (Percent) 5-Chloro-1-(4-fluorophenyl)-N- 45.0 methyl-1H-pyrazole-4-thiocarboxamide Polyfon E, an anionic lignosulfonate 3.0 wetting agent and dispersant, Westvaco Corporation Sponto 2174, an emulsifier, Witco 4.0 Chemical Corporation Ethylene Glycol 8.0 Yanthum Gum thickening agent 0.2 Antifoam C foam suppressant, Dow 0.5 Corning Corporation Water - 39.3 100.0 The above ingredients are intimately admixed and finely ground to provide a suitable suspension, which is then further diluted with water at the application site. Dust Concentration by Ingredient Weight (Percent) 5-Bromo-l- (4-chlorophenyl) -N- 10.0 methyl-lH-pyrazole-4-carboxa=ide Diatomite, a diatomaceous earth, 90.0 Witco Chemical Corporation, Inorganic Specialties Division 100.0 The active ingredient and diatomaceous earth are intimately mixed and ground to a fine powder or uniform particle size of about 16 to about 40 microns. The dust thus formed may be applied by any number of conventional methods, for example by an aerial application. Granules Concentration by Ingredient Weight (Percent) 5-Chloro-1-(2,4-difluorophenyl)- 5.0 N-methyl-1H-pyrazole-4-carboxamide Heavy aromatic naphthz . 5.0 Bentonite 20/40 mesh granular clay, 90.0 The Floridin Company ¯¯¯¯¯ 100.0 The compound is dissolved in the naphtha and sprayed onto the clay granules, typically under agitation, and the formulated granules are sieved to provide a uniform mesh size. Many of the compounds of the present invention have also exhibited useful activity against the fungal disease Septoria leaf blotch. When employed in the treatment of this plant fungal disease, the compounds are applied to the plants in a disease inhibiting and non-herbicidal amount. The term disease inhibiting and non-herbicidal amount", as used herein, refers to an amount of a compound of the invention which kills or stunts the plant disease for which control is desired, but is not significantly toxic to the plant. This amount will generally be from about 1 to 1000 ppm, with 10 to 500 ppm being preferred. The exact concentration of compound required varies with the type of formulation employed, the method of application, the particular plant species, climate conditions and the like. The compounds are preferably formulated prior to application for the control of Septoria. These formulations are similar to those outlined above for herbicidal use.

Claims: CLAIMS 1. A compound of the formula (I): EMI80.1 wherein RÚ is C1-C6 alkyl, C5-C6 cycloalkyl, EMI80.2 R2 is halogen, C1-C4 alkyl, trifluoromethyl, C1-C4 alkoxy, C1-C4 alkylthio or C1-C4 alkylsulfonyl; 3 R is hydrogen, C1-C4 alkyl or C1-C4 alkoxy; R* is cyclopropyl. C1-C4 alkyl or C1-C4 alkoxy; R5 is halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or nitro; X is O or S; and n is 0-3; with the following provisos: the combined total of carbon atoms for R3 and R4 does not exceed 5; when R1 is phenyl, R5 is C1-C4 alkyl, and R2 is halogen, alkoxy alkylthio, or alkylsulfonyl, the R5 substituent exists at other than the 2 or 6 position of the phenyl ring; when R is Cl-C4 alkoxy, R is other than C -C alkoxy; and when RÚ is phenyl, R5 is C1-C4 alkoxy and Rê is other than bromine, the R5 substituent exists at other than the 3 or 5 position of the phenyl ring. 2. A compound of formula (I) as claimed in Claim 1 wherein R2 is chlorine or bromine. 3. 5-Bromo-l- (3-fluorophenyl )-N-methyl-lfl- pyrazole-4-carboxamide. 4. A compound of formula (I) as claimed in Claim 1 wherein R2 is trifluoromethyl. 5. 5-(Trifluoromethyl)-l-tert-butyl-N methyl-lH-pyrazole-4-carboxamide. 6. A method for controlling undesired plants which comprises applying to the plants a growth inhibiting amount of a compound of formula (I) as claimed in any one of Claims 1 to 5. 7. A method for controlling the growth of aquatic algae which comprises applying to the water containing said algae a growth inhibiting amount of a compound of formula (I) as claimed in any one of Claims 1 to 5. 8. A herbicidal composition which comprises a plant growth inhibiting amount of a compound of formula (I) as claimed in any one of claims 1 to 5 associated with one or more agriculturally-acceptable carriers therefor. 9. A process for preparing a compound of formula (I) as claimed in any one of claims 1 to 5 which comprises: (a) reacting an intermediate of formula EMI81.1 where RÚ and Rê are as defined in claim 1 and A is a good leaving group, with an amine of formula HNR3R4, and (b) optionally thiating the product when it is desired to produce a compound of formula (I) in which X is sulphur. 10. A compound of formula: EMI82.1 where R1 and R2 are as defined in Claim 1 and A is halogen, hydroxy or C1-6 alkoxy.

Inventors: BECK, JAMES RICHARD, LYNCH, MICHAEL PATRICK
Applicants: ELI LILLY AND COMPANY
Application year: 1984
Main classification: C07D231
IPC codes: C07D231, C07D401, A01N43