HETEROCYCLIC HERBICIDES

Abstract: Herbicidal compositions comprising, as active ingre­ dient, a substituted tetrazole of the formula:- wherein R₁ represents an optionally substituted alkyl, cyc­ loalkyl, aryl or heteroaromatic group and R₂ represents an optionally substituted aryl group; the use of such tetrazoles as herbicides, and, as novel compounds those tetrazoles of formula I wherein R₂ is a phenyl group substituted by a nitro, alkyl, haloalkyl or haloalkylsulphonyl group.

Description: "HETEROCYCLIC HERBICIDES" The present invention relates to a composition for and a method of controlling undesired plant growth and to compounds for use in such a composition or nether. 1-Phenyl-5-phenoxy-1H-tetrazole is disclosed in J.C.S., Perkin Trans 1. (1973) No. 5 pp. 469-70, and certain analogues bearing substituents on the phenoxy group are disclosed in Tetrahedran, Vol. 38, No. 24 (1982), pp. 3775-3781. Also, German patent application 1,251,327 discloses a process for the production of I-aryl-5-chloro-1H-tetrazoles , together with the reaction of such compounds with phenol to produce the corresponding 5-phenoxy compounds. The compounds are stated to be useful in silver halide photographic emulsions; the 5-chloro compounds are also stated to have fungicidal and bactericidal activity in addition to their use as intermediates for the preparation of analogues having different substituents at the 5-position. There is no teaching in any of these references that the 5-phenoxy compounds have any herbicidal activity or any other useful biological activity. It has now been found that certain 1-aryl-5-aryloxy-1H- tetrazoles have useful herbicidal properties, and accordingly the present invention provides a herbicidal composition which comprises a carrier and, as active ingredient, a substituted tetrazole of the formula:- EMI2.1 wherein R1 represents an optically substituted alkyl, cycloalkyl, aryl or heteroanenatic group and R2 represents an optionally substituted aryl group. In each case the aryl group is preferably a pbenyl group; when an alkyl substituent is present this preferably contains fran 1 b 12, especially 1 to 6, carbon atoms; and when a cycloalkyl substitnent is present this preferably contains fran 3 to 8, especially 5-8, atoms. Preferably R1 represents an isopropyl, cyclohexyl, pyridyl, naphthyl or phenyl group, optionally substituted by a halogen, especially fluorine or chlorine, atcm, or an arno, alkyl, alkoxy or haloalkyl, especially methyl, isopropyl, methoxy, or trifluoromethyl, group. Although more than one such substituent may be present, it is preferred that a phenyl ring should be unsubstituted or monosubstituted. Preferably R2 represents a phenyl group optionally substituted by a halogen, especially chlorine or fluorine, atan, a nitro group, an aLkyl or haloalkyl, especially methyl or trifluoromethyl, grou, or haloalkylsulphonyl group, especially trifluoromethylsulphonyl. It has been found that, in general, the highest levels of herbicidal activity are found in those compounds wherein R2 is aphenyl group which is either unsubstituted or bears at least one substituent, preferably trifluoromethyl, at the 3-position. Many of the compounds of formula I are novel and the invention therefore also extends to these novel compounds per se. The novel compounds are the substituted tetrazoles of formula I wherein R1 ia as defined above and R2 is a phenyl group substituted by a nitro, alkyl, haloalkyl, or haloalkylsulphonyl group. Preferred novel compounds are those wherein R1 ia as defined above and R2 is a phenyl group substituted at the 3-position, preferably by a trifluoromethyl group. The invention also provides a process for the preparation of a novel compound of the general formula I, which comprises reacting a 5-halo tetrazole of formula II EMI3.1 with an alcohol of formula R1OH, wherein R1 is as defined above, or an alkali netal salt of sach an alcohol. The said 5-halo tetrazole may be prepared by (i) reacting an inorganic azide with an isocyano dihalide having the formula wherein R2 is as defined above and Hal represents a halogen, preferably chlorine, atan or (ii) reacting an aluminium azide with an isocyanate of formula R2NCO followed by treatment with phosphorus pentachloride. inorganic azide used in the tetrazole cyclisation step is suitably hydrazoic acid, ammonium azide, or an alkali or alkaline earth metal azide, in partictilar an alkali metal azide such as sodium azide. Both steps of the process are conveniently carried out in an inert solvent, which may be organic, such as a acetone, or inorganic, e.g. water, or a mixture thereof. The isocyanodihalide reactant may be prepared by knawn synthetic procedures, for example fan the corresponding aniline of formula v 2 by reaction with formic acid followed by a mixture of sulphuryl chloride and thionyl chloride. The compounds of the general formula I have useful herbicidal properties, and accordingly the invention provides also the use as herbicide of such a compound or a composition containing such a compound. Further, in accordance with the invention, there is provided a method of combating undesired plant growth at a locus by treating the locus with a compound or composition according to the invention. Application to the locus may be pre-emergence or post-emergence. The dosage of active ingredient used may, for example, be from 0.05 to 4kg/ha. A carrier in a composition according to the invention is any naterial with which the active ingredient is formulated to facilitate application to the locus to be treated, which may for example be a plant, seed or soil, or to facilitate storage, transport or handling. A carrier may be a solid or a liquid, including a material which is normally gaseous but which has been compressed to form a liquid, and any of the carriers normally used in formdlating herbicidal compositions may be used. Preferably compositions according to the invention contain 0.5 to 95% by weight of active ingredient. Suitable solid carriers include natural and synthetic clays and silicates, for example natural silicas such as diatataceoes earths; magnesium silicates, for example talcs; magnesium alluminium silicates, for example attapulgites and vermiculites; alluminium silicates, for example kaolinites, montomorillonites and micas; calcium carbonate; calcium sulphate; ammonium sulphate; synthetic hydrated silicon oxides and synthetic calcium or aluminium silicates; elements, for example carbon and sulphur; natural and synthetic resins, for example coumarone resins, polyvinyl chloride, and styrene polymers and copolymers; solid polychlorophenols; bitumen; and and solid fertilisers, for example superphosphates. Suitable liquid carriers include water; alcohols, far example isopropanol and glycols; ketones, for example acetone, methyl ethyl ketne, methyl isdutyl ketone and cyclohexanone; ethers; aromatic or araliphatic hydrocarbons, for example benzene, toluene and xylene; petroleum fractions, for example kerosine and light mineral oils; chlorinated hydrocarbons, for example carbon tetrachloride, perchloroethylene and trichloroethane. Mixtures of different liquids are often suitable. Agricultural oompositions are often formulated and transported in a concentrated form which is subsequently diluted by the user before application. The presence of small amounts of a carrier which is a surface-active agent facilitates this process of dilution. Thus preferably at least one carrier in a oomposition according to the invention is a surface-active agent. For example the coppOsition may contain at least two carriers, at least one of which is a surfaceactive agent. A surface-active agent may be an emulsifying agent, a dispersing agent or a wettnng agent; it may be ncnionic or ionic. Examples of suitable surface-active agents include the sodium or calcium salts of polyacrylic acids and lignin sulphenic acids; the condensation of fatty acids or aliphatic amines or amides containing at least 12 carbon atoms in the molecule with ethylene oxide and/or propylene oxide; fatty acid esters of glycerol, sorbitan, sucrose or pentaerythritol; oondensates of these with ethylene oxide and/or propylene oxide; condensation products of fatty alcohol or alkyl phenols, for example p-octylphenol or p-octylcresol, with ethylene oxide and/or propylene oxide; sulphates or sulphonates of these condesation products; alkali or alkaline earth metal salts, preferably sodium salts, of sulphuric or sulphonic acid esters containing at least 10 carbon atoms in the molecule, for example sodium lauryl sulphate, sodium secondary alkyl sulphates, sodium salts of sulphonated castor oil, and sodium alkylaryl sulphonates such as dodecylbenzene sulphonate; and polymers of ethylene oxide and copolymers of ethylene oxide and propylene oxide. The compositions of the invention may for example be formulated as wettable powers, dusts, granules, solutions, emulsificable concentrates, emulsions, suspension concentrates and aerosols. Wettable powders usually contain 25, 50 or 75% w of active ingredient and usually contain in addition to solid inert carrier, 3-10% w of a dispersing agent and, where necessary, 0-10% w of stabiliser(s) and/or other additives such as penetrants or stickers. Dusts are usually formulated as a dust concentrate having a similar composition to that of a wettable powder but without a dispersant, and are diluted in the field with further solid carrier to give a composition usually containing -10% w of active ingredient. Granules are usually prepared to have a size between 10 and 100 BS mesh (1.676 - 0.152 mm), and may be manufactured by agglomeration or impregnation techniques. Generally, granules will contain -75% w active ingredient and 0-10% w of additives such as stabilisers, surfactants, slow release modifiers and binding agents. The so-called "dry floweble powders" consist of relatively snail granules having a relatively high concentration of active ingredient. fltnlsifiable concentrates usually contain, in addition to a solvent and, when necessary, co-solvent, 10-50% w/v active ingredient, 2-20% w/v emulsifiers and 0-20% w/v of other additives such as stabilisers, penetrants and corrosion inhibitors. Suspension conentrates are usually compounded so as to obtain a stable, nonsedimenting flowable product and usually contain 10-75% w active ingredient, 0.5-15% w of dispersing agents, 0.1-10% w of suspending agents such as protective colloids and thixotropic agents, 0-10% w of other additives such as deformers, oorrosion inhibitors, stabilisers, penetrants and stickers, and water or an organic liquid in which the active ingredient is substantially insoluble; certain organic solids or inorganic salts may be present dissolved in the formulation to assist in preventing sedimentation ar as anti-freeze agents for water. Aqueous dispersions and emulsions, for example coNpositions obtained by diluting a wettable powder or a concentrate according to the invention with water, also lie within the scope of the invention. The said emulsions nay be of the water-in-oil or of the oil-in-water type, and may have a thick 'mayonnaise'-like consistency. The composition of the invention may also contain other ingredients, for example other compounds possessing herbicidal, insecticidal or fungicidal prcçesties. The following Examples illustrate the invention. Example 1 1-(3'-trifluoromethylphenyl)-5-phenoxy-1H tetrazole A) Preparation of 3-formemidobenzotrifluoride 3-trifluoromethylaniline (80.5g, 0.5 mole) and formic acid (230g, 5 mole) were refluxed for 2 hours. The mixture was cooled to roam temperature, and poured into ice/water. Product filtered, washed with water and dried to yield a solid, mpt. 51-530C. B) Preparation of 3-trifluoromethylphenyl isocyanodichloride 3-formemidobenzotrifluoride (85.05g, 0.45 mole) was added portionwise to a stirred mixture of sulphuryl chloride (60.75g, 0.45 mole) and thionyl chloride (135ml) at 20-250C. The mixture was stirred 4 hours at roan temperature then heated slowly to 80 C, hydrogen chloride and sulphur dioxide bering liberated. The excess thionyl chloride was evaporated and a small as of solid material removed by filtration. Product distilld under vacuum to yield a liquid, b.pt. 82-84 C/5mm. C) Preparation of 5-chloro-1-(3'-trifluoromethylphenyl)-1H- tetrazole A solution of the isocyanodichloride prepared in B) (7.26g, 0.03 mole) in acetone (25ml) was added to a stirred solution of sodium azide (1.95g; 0.03 mole) in water (10ml). The temperature rose to about 500C and the inxture was stirred at this tetture for 15 minutes, then heated to reflux for 30 minutes. The reaction mixture was cooled, poured into water and extracted with methylene chloride. The combined extracts were dried (MgSO4) and evaporated to leave the crude product as a yellow oil. The oil was taken up in 40-600 petrol containing just enough ethyl a acetate to effect complete solution and the product crystallised by cooling in a dry i. ice/acetone bath to yield a solid, m.pt. 44-460C. D) Preparation of 1-(3'-trifluoromethylphenyl)-5-phenoxy-1H tetrazole Auhudrous potassium carbonate (1.38g, 0.01 mole) was added to a solution of the 5-chloro product obtained in C) (1.24g, 0.005 nole) and phenol (0.47g, 0.005 mole) in dry acetone (15ml), and the mixture stirred at reflux overnight. The hot mixture was poured into ice/water, allowed to stand 1 hour and the product collected by filtration. Recrystallisation from ethanol/water yielded a solid, m.pt. 73-74 C. Analysis Calc. C 54.9 H 2.96 N 18.3% Found C 54.8 H 3.1 N 18.4% Example 2-33 Following procedures siiniiar to those described in Example 1 (except as described below), a number of additional compounds were prepared, whose melting points and chemical analyses are shown in Table I below. In that Table, the compounds are identified by renoe to the identity of the substituents in formula I. In the case of Example 29, the 5-chloro tetrazole was prepared from p.tolylisocyanate by the following procedure. A) A solution of aluninium chloride (13.3g) in dry tetrahydrofuran (150ml) was added to a suspension of sodium azide (17.6g) indry tetrahydrofuran (50ml), containing p-tolylisocyanate (12g). The reaction mixture was stirred under reflux for 24 hours, cooled in an icePwater bath and acidified with 20ml 6N hydrochloric acid. The two phase mixture was then evaporated to dryness. The residue was digested with 3x100ml portion of acetone, and after removal of the acetone the bran solid was dissolved in 250ml hot ethanol, charcoal added, and filtered. Product crystallised by the addition of water to the filtrate. B) Phosphorous pentachloride (10.4g) was added to a stirred suspension of the product of A) (8.8g) in dry boluene (100ml). The mixture was heated to reflux and stirred at reflux for 4 hours. Chromatography on a silica gel column gave the desired product, 1-(4'-methylphenyl)-5-chloro-1H terazole, which was then reacted with phenol according to the procedure described in Example 1 D. Table I EMI10.1 <SEP> Elemental <SEP> Analysis <tb> Ex. <SEP> No. <SEP> R1 <SEP> R2 <SEP> M.Pt. C <SEP> Calculated <SEP> Found <tb> <SEP> C <SEP> H <SEP> N <SEP> C <SEP> H <SEP> N <tb> <SEP> 2 <SEP> 4-Cl-Phenyl <SEP> 3-CF3-Phenyl <SEP> 107-108 <SEP> 49.3 <SEP> 2.37 <SEP> 16.4 <SEP> 49.5 <SEP> 2.5 <SEP> 16.7 <tb> <SEP> 3 <SEP> 2-Cl-Phenyl <SEP> " <SEP> 104 <SEP> 49.3 <SEP> 2.37 <SEP> 16.4 <SEP> 49.2 <SEP> 2.3 <SEP> 16.4 <tb> <SEP> 4 <SEP> 3-Cl-Phenyl <SEP> " <SEP> 82-83 <SEP> 49.3 <SEP> 2.37 <SEP> 16.4 <SEP> 49.4 <SEP> 2.3 <SEP> 16.6 <tb> <SEP> 5 <SEP> 2,4-Cl2-Phenyl <SEP> " <SEP> 130 <SEP> 44.8 <SEP> 1.88 <SEP> 14.9 <SEP> 45.0 <SEP> 1.8 <SEP> 15.0 <tb> <SEP> 6 <SEP> 3,4-Cl2-Phenyl <SEP> " <SEP> 107-108 <SEP> 44.8 <SEP> 1.88 <SEP> 14.9 <SEP> 45.1 <SEP> 1.7 <SEP> 18.0 <tb> <SEP> 7 <SEP> 3,5-Cl2-Phenyl <SEP> " <SEP> 100-102 <SEP> 44.8 <SEP> 1.88 <SEP> 14.9 <SEP> 44.7 <SEP> 1.9 <SEP> 14.9 <tb> <SEP> 8 <SEP> 4-F-Phenyl <SEP> " <SEP> 75-77 <SEP> 51.9 <SEP> 2.49 <SEP> 17.3 <SEP> 51.5 <SEP> 2.1 <SEP> 17.6 <tb> <SEP> 9 <SEP> 3-F-Phenyl <SEP> " <SEP> 84-86 <SEP> 51.9 <SEP> 2.49 <SEP> 17.3 <SEP> 51.7 <SEP> 2.3 <SEP> 17.0 <tb> <SEP> 10 <SEP> 2-Cl-4-CF3-Phenyl <SEP> " <SEP> 118-120 <SEP> 44.1 <SEP> 1.73 <SEP> 13.7 <SEP> 44.1 <SEP> 1.7 <SEP> 13.7 <tb> <SEP> 11 <SEP> 4-CH3-Phenyl <SEP> " <SEP> 87-89 <SEP> 56.2 <SEP> 3.46 <SEP> 17.5 <SEP> 56.4 <SEP> 3.6 <SEP> 17.6 <tb> <SEP> 12 <SEP> 2-CH3-Phenyl <SEP> " <SEP> 113-115 <SEP> 56.2 <SEP> 3.46 <SEP> 17.5 <SEP> 56.3 <SEP> 3.1 <SEP> 17.6 <tb> <SEP> 13 <SEP> 3-CH3-Phenyl <SEP> " <SEP> 83-85 <SEP> 56.2 <SEP> 3.46 <SEP> 17.9 <SEP> 56.2 <SEP> 3.1 <SEP> 17.7 <tb> <SEP> 14 <SEP> 2,4-(CH3)2-Phenyl <SEP> " <SEP> 92-93 <SEP> 57.5 <SEP> 3.92 <SEP> 16.8 <SEP> 57.5 <SEP> 4.1 <SEP> 16.8 <tb> <RTI ID=11.1> Table I continued... EMI11.1 <SEP> Elemental <SEP> Analysis <tb> Ex. <SEP> No. <SEP> R1 <SEP> R2 <SEP> M.Pt. C <SEP> Calculated <SEP> Found <tb> <SEP> C <SEP> H <SEP> N <SEP> C <SEP> H <SEP> N <tb> <SEP> 15 <SEP> 2,6-(CH3)2-Phenyl <SEP> 3-CF3-Phenyl <SEP> 125-127 <SEP> 57.5 <SEP> 3.92 <SEP> 16.8 <SEP> 57.1 <SEP> 4.1 <SEP> 16.7 <tb> <SEP> 16 <SEP> 4-isoC3H7-Phenyl <SEP> " <SEP> 65 <SEP> 58.6 <SEP> 4.34 <SEP> 16.1 <SEP> 58.7 <SEP> 4.6 <SEP> 16.1 <tb> <SEP> 17 <SEP> 3-Pyridyl <SEP> " <SEP> 87 <SEP> 50.8 <SEP> 2.62 <SEP> 22.8 <SEP> 50.8 <SEP> 2.6 <SEP> 22.7 <tb> <SEP> 18 <SEP> 4-Pyridyl <SEP> " <SEP> 137-139 <SEP> 50.8 <SEP> 2.62 <SEP> 22.8 <SEP> 50.7 <SEP> 2.6 <SEP> 22.7 <tb> <SEP> 19 <SEP> 3-NH2-Phenyl <SEP> " <SEP> 85 <SEP> 52.3 <SEP> 3.14 <SEP> 21.8 <SEP> 52.4 <SEP> 3.1 <SEP> 21.7 <tb> <SEP> 20 <SEP> Cyclohexyl <SEP> " <SEP> 37-39 <SEP> 53.8 <SEP> 4.84 <SEP> 17.9 <SEP> 54.4 <SEP> 4.9 <SEP> 18.0 <tb> <SEP> 21 <SEP> 3-CF3-Phenyl <SEP> " <SEP> 93-95 <SEP> 48.1 <SEP> 2.15 <SEP> 15.0 <SEP> 48.1 <SEP> 2.0 <SEP> 14.8 <tb> <SEP> 22 <SEP> 1-Naphthyl <SEP> " <SEP> 98-99 <SEP> 60.8 <SEP> 2.84 <SEP> 15.8 <SEP> 61.1 <SEP> 3.3 <SEP> 15.9 <tb> <SEP> 23 <SEP> 2-Naphthyl <SEP> " <SEP> 117 <SEP> 60.8 <SEP> 2.84 <SEP> 15.8 <SEP> 60.7 <SEP> 3.0 <SEP> 15.7 <tb> <SEP> 24 <SEP> 3-CH3O-Phenyl <SEP> " <SEP> 82-83 <SEP> 53.6 <SEP> 3.3 <SEP> 16.7 <SEP> 52.9 <SEP> 3.3 <SEP> 16.4 <tb> <SEP> 25 <SEP> 4-CH3O-Phenyl <SEP> " <SEP> 93-94 <SEP> 53.6 <SEP> 3.3 <SEP> 16.7 <SEP> 53.6 <SEP> 3.2 <SEP> 16.6 <tb> <SEP> 26 <SEP> Phenyl <SEP> " <SEP> 124-125 <SEP> 65.5 <SEP> 4.23 <SEP> 23.5 <SEP> 65.2 <SEP> 4.3 <SEP> 23.7 <tb> <SEP> 27 <SEP> " <SEP> " <SEP> 115-116 <SEP> 57.3 <SEP> 3.33 <SEP> 20.5 <SEP> 56.5 <SEP> 3.3 <SEP> 20.5 <tb> Table I continued... EMI12.1 <SEP> Elemental <SEP> Analysis <tb> Ex. <SEP> No. <SEP> R1 <SEP> R2 <SEP> M.Pt. C <SEP> Calculated <SEP> Found <tb> <SEP> C <SEP> H <SEP> N <SEP> C <SEP> H <SEP> N <tb> <SEP> 28 <SEP> " <SEP> 4-NO2-Phenyl <SEP> 180-181 <SEP> 55.1 <SEP> 3.20 <SEP> 24.7 <SEP> 54.6 <SEP> 3.0 <SEP> 24.6 <tb> <SEP> 29 <SEP> " <SEP> 4-CH3-Phenyl <SEP> 104 <SEP> 131-132 <SEP> 66.6 <SEP> 4.8 <SEP> 22.2 <SEP> 66.6 <SEP> 4.9 <SEP> 22.0 <tb> <SEP> 30 <SEP> " <SEP> 4-CF3-Phenyl84-87 <SEP> 105-106 <SEP> 54.9 <SEP> 2.96 <SEP> 18.3 <SEP> 55.0 <SEP> 2.9 <SEP> 18.3 <tb> <SEP> 31 <SEP> " <SEP> 2-CF3-Phenyl74-75 <SEP> 86 <SEP> 54.9 <SEP> 2.96 <SEP> 18.3 <SEP> 54.8 <SEP> 3.2 <SEP> 18.3 <tb> <SEP> 32 <SEP> 3-F-Phenyl <SEP> 3,5-(CF3)2-Phenyl <SEP> 84-87 <SEP> 48.1 <SEP> 2.15 <SEP> 15.0 <SEP> 48.3 <SEP> 2.0 <SEP> 14.8 <tb> <SEP> 33 <SEP> 4-Cl-Phenyl <SEP> " <SEP> 74-75 <SEP> 45.9 <SEP> 1.8 <SEP> 14.3 <SEP> 45.9 <SEP> 1.8 <SEP> 14.2 <tb> <SEP> 34 <SEP> 4-CH3-Phenyl <SEP> Phenyl <SEP> 99-100 <tb> <SEP> 35 <SEP> 2-Cl-Phenyl <SEP> Phenyl <SEP> 91-92 <SEP> 66.7 <SEP> 4.8 <SEP> 22.2 <SEP> 66.6 <SEP> 4.8 <SEP> 22.1 <tb> <SEP> 36 <SEP> Phenyl <SEP> Phenyl <SEP> 78-79 <SEP> 57.2 <SEP> 3.3 <SEP> 20.5 <SEP> 57.5 <SEP> 3.4 <SEP> 20.6 <tb> <SEP> 37 <SEP> Phenyl <SEP> 3-NO2-Phenyl <SEP> 115-117.5 <SEP> 55.2 <SEP> 3.2 <SEP> 24.7 <SEP> 55.0 <SEP> 3.1 <SEP> 24.7 <tb> <SEP> 38 <SEP> Phenyl <SEP> 3-CF3SO2-Phenyl <SEP> 118-119 <SEP> 45.4 <SEP> 2.4 <SEP> 15.1 <SEP> 45.4 <SEP> 2.4 <SEP> 15.2 <tb> <SEP> 39 <SEP> Phenyl <SEP> 2-Cl,3-CF3-Phenyl <SEP> 85-88 <SEP> 49.4 <SEP> 2.4 <SEP> 16.4 <SEP> 49.1 <SEP> 2.3 <SEP> 16.2 <tb> <SEP> 40 <SEP> Phenyl <SEP> 4-Cl,3-CF3-Phenyl <SEP> 119-121 <SEP> 49.4 <SEP> 2.4 <SEP> 16.4 <SEP> 49.4 <SEP> 2.1 <SEP> 16.3 <tb> <SEP> 41 <SEP> Phenyl <SEP> 4-NO2,3-CF3-Phenyl <SEP> 104-106 <SEP> 47.9 <SEP> 2.3 <SEP> 19.9 <SEP> 47.7 <SEP> 2.2 <SEP> 19.9 <tb> <SEP> 42 <SEP> Phenyl <SEP> 4-F,3-CF3-Phenyl <SEP> 90 <SEP> 51.9 <SEP> 2.5 <SEP> 17.3 <SEP> 51.8 <SEP> 2.5 <SEP> 17.4 <tb> <SEP> 43 <SEP> i-C3H7 <SEP> 3-CF3-Phenyl18-120 <SEP> oil <SEP> 48.5 <SEP> 4.1 <SEP> 20.6 <SEP> 48.6 <SEP> 4.3 <SEP> 20.8 <tb> Example 44 Herbicidal Activity To evaluate their herbicidal activity, compounds according to the invention were tested using as a representative range of plants: maize, Zea ays (Mz); rice, Oryza sativa (R); barnyard grass, Echinochlos crusgalli (BG); oat, Avena sativa (0); linseed, Linus usitatissisum (L); mustard, Sinapsis alba (N); sugar beet, Betavulgaris (SB) and soya bean, Glycine max (S). The tests fall into two categories, pre-emergence and post-emergence. he pre-emergence tests involved spraying a liguid formulation of the compound onto the soil in which the seeds of the plant species mentioned above had recently been sown. The e post-emersence tests involved two types of test, viz., soil drench and foliar spray tests. In the soil drench tests the soil in which the seedling plants of the above species were growing was drenched with a liquid formulation containing a carpound of the invention, and in the foliar spray tests the seedling plants were sprayed with such a formulation. The soil used in the tests was a prepared horticultural lom. The formulations used in the tests ware Prepared frrrn solutions of the test compounds in acetone containing 0.4% by weight of an alkylphenol/ethylene oxide condensate available under the trade mark TRITON X-155. These acetone solutions were diluted with water and the resulting formulations applied at dosage levels corresponding to 5 kg or 1 kg of active material per hectare in a volume equivalent to 600 litres per hectare in the soil spray and foliar spray tests, and at a dosage level equivalent to 10 kilograms of active material per hectare in a volume equivalent to approximately 3,000 litres per hectare in the soil drench tests. In the pre-emergence tests untreated sown soil and in the post-errergence tests untreated soil bearing seedling plants ware used as controls. The berbicidal effects of the test carpounds ware assessed visually twelve days after spraying the foliage and the soil, and thireen days after drenching the soil and were recorded on a 0-9 scale. A rating 0 indicates growth as untreated control, a rating 9 indicates death. An increase of 1 unit on the linear scale approximates to a 10% increase in the level of effect. The results of the tests are set out in Table II below. Table II EMI15.1 Compound <SEP> Soil <SEP> Drench <SEP> 10 <SEP> kg/ha <SEP> Dosage <SEP> Foliar <SEP> Spray <SEP> Pre-emergence <tb> of <SEP> Example <SEP> kg/ha <tb> Number <SEP> Mz <SEP> R <SEP> BG <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <SEP> Mz <SEP> R <SEP> BG <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <SEP> Mz <SEP> R <SEP> BG <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <tb> <SEP> 1 <SEP> 4 <SEP> 4 <SEP> 6 <SEP> 5 <SEP> 6 <SEP> 8 <SEP> 8 <SEP> 3 <SEP> 5 <SEP> 8 <SEP> 5 <SEP> 8 <SEP> 8 <SEP> 9 <SEP> 9 <SEP> 9 <SEP> 5 <SEP> 4 <SEP> 3 <SEP> 9 <SEP> 7 <SEP> 7 <SEP> 9 <SEP> 9 <SEP> 1 <tb> <SEP> 1 <SEP> 3 <SEP> 2 <SEP> 7 <SEP> 6 <SEP> 8 <SEP> 8 <SEP> 8 <SEP> 4 <SEP> 3 <SEP> 2 <SEP> 9 <SEP> 6 <SEP> 5 <SEP> 7 <SEP> 9 <SEP> 1 <tb> <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 0 <SEP> 0 <SEP> 2 <SEP> 0 <SEP> 4 <SEP> 7 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 1 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 2 <SEP> 5 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 4 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 2 <SEP> 0 <SEP> 2 <SEP> 3 <SEP> 8 <SEP> 9 <SEP> 4 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 6 <SEP> 5 <SEP> 2 <SEP> 4 <SEP> 6 <SEP> 0 <tb> <SEP> 1 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 1 <SEP> 6 <SEP> 8 <SEP> 2 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 3 <SEP> 0 <SEP> 1 <SEP> 4 <SEP> 0 <tb> <SEP> 13 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 4 <SEP> 3 <SEP> 3 <SEP> 4 <SEP> 4 <SEP> 4 <SEP> 6 <SEP> 6 <SEP> 0 <SEP> 2 <SEP> 8 <SEP> 4 <SEP> 3 <SEP> 4 <SEP> 8 <SEP> 0 <tb> <SEP> 1 <SEP> 3 <SEP> 3 <SEP> 3 <SEP> 3 <SEP> 2 <SEP> 2 <SEP> 3 <SEP> 4 <SEP> 0 <SEP> 0 <SEP> 6 <SEP> 4 <SEP> 3 <SEP> 0 <SEP> 5 <SEP> 0 <tb> <SEP> 8 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 6 <SEP> 4 <SEP> 2 <SEP> 5 <SEP> 7 <SEP> 8 <SEP> 8 <SEP> 4 <SEP> 0 <SEP> 0 <SEP> 8 <SEP> 6 <SEP> 6 <SEP> 8 <SEP> 9 <SEP> 6 <tb> <SEP> 1 <SEP> 2 <SEP> 2 <SEP> 2 <SEP> 2 <SEP> 5 <SEP> 5 <SEP> 6 <SEP> 4 <SEP> 0 <SEP> 0 <SEP> 6 <SEP> 2 <SEP> 3 <SEP> 4 <SEP> 9 <SEP> 2 <tb> <SEP> 14 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 2 <SEP> 4 <SEP> 2 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 1 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 2 <SEP> 3 <SEP> 2 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> Table II continued EMI16.1 Compound <SEP> Soil <SEP> Drench <SEP> Dosage <SEP> Foliar <SEP> Spray <SEP> Pre-emergence <tb> of <SEP> Example <SEP> 10 <SEP> kg/ha <SEP> kg/ha <tb> Number <SEP> Mz <SEP> R <SEP> RB <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <SEP> Mz <SEP> R <SEP> BG <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <SEP> Mz <SEP> R <SEP> BG <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <tb> 16 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 2 <SEP> 3 <SEP> 3 <SEP> 4 <SEP> 5 <SEP> 5 <SEP> 3 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 1 <SEP> 2 <SEP> 2 <SEP> 2 <SEP> 2 <SEP> 2 <SEP> 5 <SEP> 3 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> 17 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 5 <SEP> 4 <SEP> 4 <SEP> 4 <SEP> 6 <SEP> 9 <SEP> 4 <SEP> 4 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 1 <SEP> 2 <SEP> 3 <SEP> 2 <SEP> 3 <SEP> 2 <SEP> 4 <SEP> 4 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> 20 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 3 <SEP> 0 <SEP> 7 <SEP> 4 <SEP> 5 <SEP> 6 <SEP> 5 <SEP> 6 <SEP> 1 <SEP> 1 <SEP> 7 <SEP> 5 <SEP> 2 <SEP> 5 <SEP> 6 <SEP> 2 <tb> <SEP> 1 <SEP> 2 <SEP> 0 <SEP> 4 <SEP> 2 <SEP> 4 <SEP> 4 <SEP> 3 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 3 <SEP> 3 <SEP> 0 <SEP> 3 <SEP> 3 <SEP> 0 <tb> 9 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 3 <SEP> 0 <SEP> 8 <SEP> 6 <SEP> 8 <SEP> 9 <SEP> 8 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 6 <SEP> 5 <SEP> 6 <SEP> 6 <SEP> 9 <SEP> 0 <tb> <SEP> 1 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 3 <SEP> 5 <SEP> 7 <SEP> 7 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 3 <SEP> 4 <SEP> 2 <SEP> 7 <SEP> 0 <tb> 26 <SEP> N/T <SEP> 5 <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> - <SEP> N/T <tb> <SEP> 1 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 3 <SEP> 4 <SEP> 4 <SEP> 3 <SEP> 4 <tb> Table 1 continued .... EMI17.1 Compound <SEP> Soil <SEP> Drench <SEP> Dosage <SEP> Foliar <SEP> Spray <SEP> Pre-emergence <tb> of <SEP> Example <SEP> 10 <SEP> kg/ha <SEP> kg/ha <tb> Number <SEP> Mz <SEP> R <SEP> RB <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <SEP> Mz <SEP> R <SEP> BG <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <SEP> Mz <SEP> R <SEP> BG <SEP> O <SEP> L <SEP> M <SEP> SB <SEP> S <tb> 38 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 4 <SEP> 3 <SEP> 4 <SEP> 2 <SEP> 4 <SEP> 4 <SEP> 4 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 1 <SEP> 1 <SEP> 2 <SEP> 2 <SEP> 1 <SEP> 2 <SEP> 3 <SEP> 1 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> 39 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 5 <SEP> 2 <SEP> 2 <SEP> 0 <SEP> 4 <SEP> 7 <SEP> 8 <SEP> 6 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 1 <SEP> 4 <SEP> 2 <SEP> 2 <SEP> 0 <SEP> 2 <SEP> 5 <SEP> 5 <SEP> 5 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> 41 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 5 <SEP> 2 <SEP> 4 <SEP> 0 <SEP> 0 <SEP> 3 <SEP> 2 <SEP> 4 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> <SEP> 1 <SEP> 2 <SEP> 1 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 2 <SEP> 1 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <tb> 43 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 5 <SEP> 3 <SEP> 2 <SEP> 3 <SEP> 4 <SEP> 4 <SEP> 0 <SEP> 3 <SEP> 4 <SEP> 4 <SEP> 2 <SEP> 8 <SEP> 4 <SEP> 3 <SEP> 4 <SEP> 8 <SEP> 4 <tb> <SEP> 1 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 0 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 3 <SEP> 0 <SEP> 0 <SEP> 3 <SEP> 2 <SEP> 0 <SEP> 0 <SEP> 3 <SEP> 2 <tb>

Claims: CLAIMS 1. A herbicidal composition which comprises a carrier and, as active ingredient, a substituted tetrazole of the formula: EMI18.1 wherein R1 represents an optionally substituted alkyl, cycloalkyl, aryl or heteroaromatic group and R2 represents an optionally substituted aryl group. 2. A composition as claimed in claim 1 in which the active ingredient is a tetrazole of formula I wherein represents an isopropyl, cyclohexyl, pyridyl, naphthyl or phenyl group, optionally substituted by a halogen atom or an amino, alkyl, alkoxy or haloalkyl group. 3. A composition as claimed in claim 2 wherein R1 represents a phenyl group optionally mono-substituted by a fluorine or chlorine atom or a an amino, methyl, isopropyl, methoxy or trifluoromethyl group. 4. A composition as claimed in any one of claims 1, 2 or 3 in which the active ingredient is a tetrazole of formula I wherein R2 represents a phenyl group optionally substituted by a halogen atom, a nitro group, an alkyl or haloalkyl group, or a haloaltylsulphonyl group. 5. A composition as claimed in claim 4 wherein R2 represents a phenyl group optionally substituted at the 3-position by a trifluoromethyl group. 6. A composition as claimed in any one of the preceding claims wherein the tetrazole of formula I is any one of those named in Ertples 1-43 herein. 7. A substituted tetrazole of the formula I as shewn in claim 1, wherein R1 is as defined in claim 1 and RI represents a phenyl group substituted by a nitro, alkyl, haloalkyl, or haloalkylsulphonyl group. 8. A substituted tetrazole as claimed in claim 7 wherein R, represents a phenyl group optionally mono-substituted by a fluorine or chlorine atom or an amino, methyl, isopropyl, methoxy or trifluormethyl group. 9. A substituted tetrazole as claimed in claim 7 or 8 wherein R2 represents a phenyl group substituted at the 3-position by a trifluoromethyl group. 10. A process for the Preparation of a compound as claimed in claim 7, which comprises reacting a 5-halotatrazole of formula = EMI19.1 with an alcohol of formula R1OH, wherein R1 and R2 are as defined in claim 7, or an alkali metal salt of such an alcohol. 11. Process as claimed in clam 10 wherein the 5-halo tetrazole of formula II is prepared by reacting (i) an isocyanate of formula R2NCO with aluminium azide followed by phosphorus pentachloride, or (ii) an isocyamo dihalide of formula R2N-C(Hal)2 with an inorganic azide; R2 bein as defined in claim 7 and Hal representing a halogen atan. 12. A compound as claimed in clam 7 whenever Prepared by a process as claimed in claim 10 or 11. 13. Method of combating undesired growth at a locus, which comprises treating the locus with a composition as claimed in any ane of claims 1-6 or a compound as claimed in any one of claims 7-9 or 12. 14. Use as a herbicide of a substituted tetrazole as defined in any one of claims 1-9 or 12.

Inventors: MANSURI, MUZAMMIL MANSOOR, MCARTHUR, ALASDAIR
Applicants: SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
Application year: 1984
Main classification: A01N43
IPC codes: C07D401, C07D257, A01P13, A01N43