LIQUID DETERGENT WITH SUNSCREEN AGENT

Abstract: A composition comprising a sunscreen agent, a preser­ vative, and a non-ionic detergent, an amphoteric detergent or a mixture thereof in an aqueous vehicle. The sunscreen agent is selected from an aminobenzoic acid, the esters of an aminobenzoic acid, homosalate, cinoxone, and oxybenzone and is present in an amount of not less than about 1 percent by weight of the composition. The method of controlling ultra-violet absorption is also disclosed.

Description: This invention relates to a sunscreen detergent and a method of controlling the absorption of ultra-violet light by skin exposed to ultra-violet light. Exposure to ultra-violet light primarily through exposure to the sun's rays produces a number of harmful effects including premature aging, loss of elasticity, wrinkling, drying, and not least, an increased risk of developing skin cancer. Currently a number of sunscreen and suntan products are marketed to protect against these harmful effects. All of these products contain agents known to filter-out some of the sun's harmful rays incorporated into creams, ointments, lotions, solutions or suspensions. Such products are applied just prior to anticipated sun exposure and provide short term protection and are removed by bathing, washing or normal desquamation of skin. We have discovered that such sunscreens can be effectively incorporated into nonionic and amphoteric liquid detergents so that repeated washing and bathing with such detergents leaves a long-lasting substantive and effective amount of the incorporated sunscreen in the stratum corneum of the skin. Previous attempts to incorporate sunscreens into soaps have failed because ionic soaps would rapidly degrade the incorporated sunscreen. The object of the present invention is to provide a liquid detergent or soap containing an effective sunscreen agent therein such that washing with these detergents leaves a long-lasting substantive amount of the sunscreen in the stratum corneum of the skin. The document "Happi Household and Personal Products Industry" 18 (April 1981) p.48 discloses a non-ionic sunscreen cream and separately discloses a conditioning shampoo. However, there is no suggestion to combine the shampoo and the sunscreen. Accordingly, the present invention provides a liquid combination sunscreen detergent for use on skin comprising (a) a liquid detergent component consisting essentially of an aqueous solution of a non-ionic detergent or an amphoteric detergent or mixtures thereof and (b) a sunscreen agent, said suncreen agent being present in an amount effective so that, when said combination sunscreen detergent is used to wash the skin, followed by rinsing, the absorption of ultraviolet light by the skin will be reduced when the skin is thereafter exposed to ultraviolet light, so as to provide noticeable protection from sunburn. The present invention also provides a method of controlling the absorption of ultraviolet light by skin exposed to ultraviolet light, comprising the steps of : (a) applying to the skin a liquid combination sunscreen detergent as claimed in any preceding claim and (b) rinsing said sunscreen detergent from the skin prior to exposure of the skin to the ultraviolet light. These and other features of the present invention may be more readily understood when considered in conjunction with the following description and Examples which are exemplary in nature only. For the purposes of this application, the term "detergent" is used in its broadest sense to include technical soaps (sponification of fats and oils) as well as synthetic soaps or detergents, many of which are addition products of ethylene oxide and a compound with an active hydrogen atom. The principal requirement of the present invention is that the detergent or the soap be either non-ionic or amphoteric in character. Chemically, a soap may be represented as R-COOM wherein R is a straight chain hydrocarbon radical, either saturated or unsaturated and normally with 7 to 21 carbon atoms. The COO- moiety is the residue of a carbocyclic acid group and is characteristic of natural soaps. M is a base forming material, either inorganic or organic. As is well known, various animal fats as well as vegetable oils may be used as a constituent in the soap or detergent. One of the preferred vegetable oils is coconut oil which contains a high proportion of saturated fatty acids but has a low average molecular weight, being a liquid at ambient temperatures. Olive oil while having a high average molecular weight contains a high proportion of unsaturated fatty acids, also being liquid at ambient temperatures. The invention principally concerns liquid detergents which includes in its definition the aforementioned soaps. Any well known sunscreening agent may be used; however, the preferred sunscreening agents are listed below. In all cases where weight percents are listed after the sunscreen agent, the lower number in the range is thought to be the least amount of sunscreen effective if used alone without additional sunscreening agents while the higher number in the range indicates the maximum amount thought to be economically feasible to put into a liquid detergent. Adding a greater amount of sunscreen agent is not deleterious, simply more expensive. However, as the concentration of sunscreen agents is increased, less ultra-violet is accepted by the skin resulting in less tanning. In the practice of this invention sunscreen detergents are prepared by incorporating a variety of chemically dissimilar sunscreen agents into nonionic or amphoteric liquid detergents. The following sunscreen agents were incorporated into various liquid detergent vehicles: amino-benzoic acid, 5-15 percent (all percents provided are calculated as weight/weight): cinoxate (2-ethoxyethyl p-methoxycinnamate), 1-3 percent; digalloyl trioleate, 2-5 percent; 2 ethylhexyl p-methoxycinnamate, 2-5 percent; glyceryl p-aminobenzoate, 2-3 percent; homosalate, 4-15 percent; dioxybenzone, 0.5-5 percent; oxybenzone (2-hydroxy-4-methoxybenzophenone), 0.5-5 percent, padimate A (pentyl p-[p-dimethylamino] benzoate), 1-4 percent, padimate ) (2-ethylhexyl [p-dimethylamino] benzoate) 1-4 percent. Not all of these agents are equally effective when incorporated into the nonionic or amphoteric liquid detergents nor do all provide equivalent substantivity (long-lastingness). For example, 15 percent homosalate provides far less sun protection than aminobenzoic acid 5 percent after 1,5, and 14 days of washing. However, all the named sunscreen agents do provide substantive ultra-violet protection to some degree. EXAMPLE 1 A nonionic liquid detergent vehicle was prepared by incorporating into water 5 percent by weight exthoxylated phenols, 1 percent by weight acetylated ethoxylated lanolin. To that was added a sunscreen agent, aminobenzoic acid, in the amount of 5 percent by weight. The aqueous mixture was used twice daily to cleanse a 25cm² square area of skin on the forearm. At the end of ten days the treated area and a 25cm² untreated area on the opposite forearm were exposed to a Hanovia quartz lamp at 10 inches distances for 20 minutes. Sunburn erythema was marked in the untreated area 8 hours after exposure, but not observed in the sunscreen detergent washed area. EXAMPLE 2 A combination nonionic and amphoteric liquid detergent was prepared by adding to water 10 weight percent of a coconut based imidazoline derivative (Miranol), 15 percent by weight cocoamidobetaine, 0.5 percent by weight polysorbate, 0.7 percent by weight of a viscosity adjusting agent quarternary polymer, 0.1 percent by weight methyl paraben as a preservative for the amphoteric detergent. To this mixture was added 1.5 percent aminobenzoic acid. This detergent composition was used daily for two weeks by a 12 year old boy with a sun-sensitive skin prior to swimming in a swimming pool. Although the boy swam and sunbathed for 4 hours, no sunburn erythema developed. EXAMPLE 3 A nonionic detergent was prepared by adding a 5 percent by weight polysorbate to water and to that was added 1 percent cinoxate as a sunscreen agent. The composition was used for daily washing for 6 weeks by a 37 year old woman. After 4 weeks of use this woman travelled to Florida where she was exposed to significant amounts of sunlight with sunburning. EXAMPLE 4 An amphoteric liquid detergent was prepared by adding to water 10 percent by weight cocoamidobetaine, 5 percent by weight ammonium lauryl ether sulfate, 0.1 percent by weight propyl paraben as a preservative for the amphoteric detergent and to this was added 2.5 percent by weight glyceryl p-aminobenzoate as a sunscreen agent. This detergent composition was used twice daily to cleanse a 25cm² area of skin on the forearm. At the end of 10 days, the treated area and a 25cm² untreated area on the opposite arm were exposed to a Hanovia quartz lamp at 10 inches distance for 20 minutes. Sunburn erythema was deep red in the untreated area 8 hours after exposure, but only very faint pink in the treated area. EXAMPLE 5 A combination nonionic and amphoteric liquid detergent was prepared by adding to water 5 percent by weight ethoxylated phenols, 10 percent by weight coconut based imidazoline derivative (Miranol)®, and 2 percent by weight sodium lauryl ether sulfate; also added as a preservative was 0.1 percent by weight methyl paraben and 0.1 percent by weight propyl paraben; also added as a viscosity adjusting agent was 0.7 percent quarternary polymer. To this was added 2 percent by weight homosalate. The resulting detergent composition was used to cleanse a 25cm² area of the forearm once daily for 4 weeks. At the end of this 4 week period, the treated arm and a 25cm² untreated area on the opposite forearm were exposed to a Hanovia quartz lamp at 10 inches distance for 20 minutes. Sunburn erythema was less marked in the detergent washed area 8 hours after exposure than was the untreated area. EXAMPLE 6 A nonionic liquid detergent comprised of water vehicle having 5 percent by weight polysorbate was used with 2 percent by weight oxybenzone to wash the right forearm of a volunteer subject 12 times in a 6 hour period. The left arm was washed with only the plain nonionic liquid detergent without the oxybenzone. At the end of the 6 hour period both forearms were exposed to 20 minutes U.V. light from a Hanovia quartz lamp at 10 inches distance. The following morning sunburn erythema was observed in the left arm but not in the right arm. EXAMPLE 7 A nonionic liquid detergent vehicle comprised of water and 2.5 percent by weight polysorbate in water was prepared with 2.5 percent by weight padimate A added as a sunscreen agent. The resulting detergent composition was used as set forth in Example 6 to wash the forearms of a 39 year old man prior to sun exposure. The sunscreen containing nonionic liquid deterent composition provided superior protection from the harmful U.V. rays as compared to the plain nonionic liquid detergent. EXAMPLE 8 An amphoteric liquid detergent was prepared by adding to water 12 percent by weight of a coconut based imidazoline derivate (Miranol)®, a 15 percent by weight cocoamidobetaine, a preservative consisting of 0.1 percent by weight methyl paraben and 0.1 percent by weight propyl paraben, a sunscreening agent of padimate 0 in the amount of 5 percent by weight and a viscosity adjusting agent of quarternary polymer present in the amount of 0.7 percent by weight and 1 percent by weight of an acetylated ethoxylated lanolin. The lanolin was used to provide better cosmetic properties to the composition. The amphoteric liquid detergent composition was used by a 39 year old male to wash twice daily for 14 days which provided noticeable protection from sunburn upon exposure to ultra-violet rays. It will be seen therefore that there has been provided a plurality of liquid detergent vehicles each provided with an effective sunscreen agent therein. These nonionic and/or amphoteric vehicles are stable over long periods of time and provide substantive and effective sunscreen agents to the stratum corneum of the skin.

Claims: A liquid combination sunscreen detergent for use on skin comprising (a) a liquid detergent component consisting essentially of an aqueous solution of a non-ionic detergent or an amphoteric detergent or mixtures thereof and (b) a sunscreen agent, said suncreen agent being present in an amount effective so that, when said combination sunscreen detergent is used to wash the skin, followed by rinsing, the absorption of ultraviolet light by the skin will be reduced when the skin is thereafter exposed to ultraviolet light, so as to provide noticeable protection from sunburn. A liquid combination sunscreen detergent according to claim 1 wherein said sunscreen agent is selected from the group consisting of aminobenzoic acid, one or more esters of aminobenzoic acid, homosalate, cinoxate, and oxybenzone,said sunscreen detergent further comprising a preservative which is present in an amount of up to 0.5 percent by weight of the total composition. A liquid combination sunscreen detergent according to claim 1 or claim 2, wherein said sunscreen agent is present in an amount of not less than 1 percent by weight of the total amount of detergent. A liquid combination sunscreen detergent according to any of claims 1 to 3 wherein said detergent is non-ionic and is an ethoxylated phenol. A sunscreen detergent according to any of claims 1 to 3, wherein said detergent is an amphoteric detergent and is a vegetable oil based compound; a coconut oil based compound; a coconut based imidazoline compound; a sulfate of a long chain hydrocarbon radical having from 7 to 21 carbon atoms; or ammonium lauryl ether sulfate. A sunscreen detergent according to claim 1, wherein said detergent includes an amphoteric detergent and further includes a preservative. A sunscreen detergent according to claim 2 or claim 6 wherein said preservative is a paraben. A sunscreen detergent according to claim 7, wherein said preservative is a methyl or propyl paraben present in an amount of 0.1 percent by weight of the sunscreen detergent. A sunscreen detergent according to any preceding claim wherein said sunscreen agent comprises one or more of glyceryl p-aminobenzoate, padimate A, and padimate O. A sunscreen detergent according to any of claims 1 to 9 further including a viscosity adjusting agent. A method of controlling the absorption of ultraviolet light by skin exposed to ultraviolet light, comprising the steps of: (a) applying to the skin a liquid combination sunscreen detergent as claimed in any preceding claim and (b) rinsing said sunscreen detergent from the skin prior to exposure of the skin to the ultraviolet light. A method as claimed in claim 11 wherein said liquid combination sunscreen detergent is applied periodically to the skin prior to rinsing said sunscreen detergent from the skin.

Inventors: BERNSTEIN, JOEL E.
Applicants: SOFT SHEEN PRODUCTS, INC.
Application year: 1984
Main classification: A61K7
IPC codes: C11D1, A61K8, A61Q19, A61Q17