NAPHTHALENE ANTI-PSORIATIC AGENTS

Abstract: Psoriasis in mammals is relieved by topically adminis­ tering naphthalenes of the formula: wherein: R¹ and R² are the same and are lower alkoxy, lower al­ kylthio, optionally substituted phenoxy or optionally substi­ tuted phenylthio, R³ is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R³ is optionally substituted phenyl, optionaily substituted phenyl lower alkyl, optionally substituted phenyl lower alk­ oxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O) n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or option­ ally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharma­ ceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, optionally sub­ stituted phenyl or optionally substituted benzyl.

Description: NAPHTHALENE ANTI"PSORIATIC AGENTS The invention relates to naphthalene derivatives which are useful in inhibiting certain dermatological conditions. This invention also relates to pharmaceutical compositions useful in relieving the effects of certain chronic recurrent papulosquamous dermatoses, e.g., psoriasis. This invention also relates to a process for preparing compounds of this invention. Psoriasis is a skin disease characterized in part by excessive proliferation of cells of the epidermis which remain strongly adherent and build up into a scaly plaaue typical of the disease. Currently available therapies, which are not curative, depend on the control of epidermal cell proliferation through the use of hormonal agents, such as corticosteroids or through the use of compounds related to cancer chemotherapy such as hydroxyurea, methotrexate, and the nitrogen mustards. While the above agents are effective to a certain extent, they cause numereus severe undesirable side effects including renal irritation, hepatic toxicity, and erythema. The compound, 2,3-dimethoxy-1,4-diacetyloxynaphthalene is known and is disclosed to be useful as a synthetic intermediate, but no useful biological activity has been ascribed to it. See J. Chem. Res., Synop. 1980(4), 156-7 and An. Quim. 1976, 72(3):247-53. Certain naphthoquinones are known to be useful in treating psoriasis. See, for example, U.S. Patent No. 4,229,478 and British Patent No. 1,243,401. But, these compounds have one or more drawbacks such as causing skin irritation, staining the skin and sensitizing the patient. Surprisingly, it has been discovered that the compounds of the instant invention are also effective antipsoriatic agents and are less irritating, do not stain the skin and do not sensitize when used in the treatment of psoriasis. Further, the compounds of the present invention are more stable in the topical formulations normally used. The present invention relates to a pharmaceutical composition in a form suitable for topical administration to mammals comprising a compound of the following formula EMI2.1 wherein: R1 and R2 are the same and are lower alkoxy of one to six carbon atoms, lower alkylthio of one to six carbon atoms, phenoxy or phenythio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; R3 is lower alkyl of one to six carbon atoms, lower alkoxy of one to six carbon atoms, or halo and m is 0, 1 or 2 or R is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, or s(o) n R wherein R is lower alkyl of one to six carbon atoms; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, phenyl or benzyl optionally substituted with one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; with the proviso that when R1 and R2 are optionally substituted phenoxy or optionally substituted phenylthio, m is 0, 1, or 2; with the proviso that when W is an alkyl group of two to seven carbon atoms and R1 and R2 are alkoxy of two to six carbon atoms, m is 0 or 2. Another aspect of the invention is a method for relieving the condition of psoriasis in a mammal which comprises topically administering to said mammal a psoriasis-relieving amount of a compound of formula (I). Another aspect of the invention is the novel compounds of formula (I) wherein R1, R2, R3, W, m and n are as defined above with the proviso that m is not o or 1 when R1 and R2 are methoxy and W is methyl. Yet another aspect of the invention is preparing compounds of formula (I) by reacting compounds of formula (XI)(infra) with an acid anhydride. In its broadest aspect, the present invention relates to a pharmaceutical composition in a form suitable for topical administration to mammals comprising a compound of the following formula EMI4.1 wherein: R1 and R2 are the same and are lower alkoxy of one to six carbon atoms, lower alkylthio of one to six carbon atoms, phenoxy optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; ; R is lower alkyl of one to six carbon atoms, lower alkoxy of one to six carbon atoms, or halo and m is 0, 1 or 2 or R3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, or S(O)nR wherein R is lower alkyl of one to six carbon atoms; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, phenyl or benzyl optionally substituted with one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo, with the proviso that when R and R2 are optionally substituted phenoxy or optionally substituted phenylthio, m is 0, 1, or 2; with the proviso that when W is an alkyl group of two th seven carbon atoms and RÚ and Rê and alkoxy of two to six carbon atoms, m is 0 or 2. The present invention also relates to compounds of the formula EMI5.1 wherein: R1 and R2 are the same and are lower alkoxy of one to six carbon atoms, lower alkylthio of one to six carbon atoms, phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; R3 is lower alkyl of one to six carbon atoms, lower alkoxy of one to six carbon atoms, or halo and m is 0, 1 or 2 or Era is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, or S(0)nR wherein R is n lower alkyl of one to six carbon atoms; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, phenyl or benzyl optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; with the proviso that n is not 0 or 1 when R1 and R2 are methoxy and W is methyl. More specifically, the present invention relates to compositions containing compounds of formula (I) wherein 3 m is 1 and R is in the 6-position and is hydrogen, bromo, chloro, fluoro or cyano. An even more specific embodiment of the instant invention are compounds of formula (I) wherein m is 1 and R3 is at the 6-position and is bromo, chloro, fluoro, cyano, methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy, and i-butoxy. Within this specific embodiment of the instant invention, a preferred group of compounds of formula (I) 2 are those wherein R1 and R2 are the same and are lower alkoxy of one to three carbon atoms and W is lower alkyl of one to five carbon atoms. Another embodiment of the invention are compounds wherein m is 2 and the two R3s are at the 6 and 7 positions and are lower alkyl, lower alkoxy or halo with R3 being methyl being preferred. Another embodiment of the invention are compounds wherein at least two of the groups R1, R2 or W contain an optionally substituted phenyl. Within this embodiment of the invention is a group of compounds wherein each W is an optionally substituted phenyl or an optionally substituted benzyl and R1 and R2 are the same and are lower alkoxy or lower alkylthio. Another group of compounds are those wherein each W is an alkyl group and R1 and R2 are the same and are optionally substituted phenyl or optionally substituted phenylthio. Still another group of compounds are those wherein each W is an optionally substituted phenyl or optionally substituted benzyl and R1 and R2 are the same and are optionally substituted phenoxy or optionally substituted phenylthio. In the present specification and claims the term "alkyl" is intended to mean alkyl groups containing one to seven carbon atoms including straight chain groups, or branched chain groups. Illustrative of such groups are for example, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, n-pentyl, i-pentyl, n-hexyl, 2-methylpentyl, and n-heptyl. The term "lower alkyl" refers to alkyl groups of one to six carbon atoms as defined above. Examples of "lower alkyl" groups are methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, 2,2-dimethylpropyl and t-hexyl. The term "phenyl lower alkyl" refers to an optionally substituted phenyl ring attached to an alkylene chain of one to six carbon atoms. The term "lower alkoxy" refers to a straight or branched chain aliphatic group of one to six carbon atoms having bonded thereto an oxygen moiety. Examples of "lower alkoxy" are methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy, i-butoxy, s-butoxy, t-butoxy and n-pentyloxy. "Phenyl low¯ alkoxy" refers to a phenyl ring attached to an alkylene chain of one to six carbon atoms having bonded thereto an oxygen atom. Examples of "phenyl lower alkoxy" are benzyloxy, 4-chlorophenylethoxy and phenyl-n-propoxy. The term "lower alkylthio" refers to a straight or branched chain aliphatic group of one to six carbon atoms having bonded thereto a sulfur moiety. Examples of "lower alkylthio" are methylthio, ethylthio, n-propylthio, i-butylthio an n-hexylthio. Optionally substituted phenyl refers to a phenyl ring optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo, lower acyl, lower acyloxy, cyano, nitro, amino and lower acylamino unless otherwise defined. The term "halo" refers to fluoro, chloro, and bromo. The term "cyano" refers to the group -CN. The term "amino" refers to the group -NH2. The term "lower alkylamino" refers to an amino group substituted by lower alkyl as is defined above. Examples of "lower alkylamino" are methylamino, ethylamino and n-butylamino. The term "lower dialkylamino" refers to an amino group substituted by two lower alkyl groups. Examples of "lower dialkylamino" are di-n-methylamino, dipropylamino and methylethylamino. The term "lower acyl" refers to the group R4C(O)wherein R4 is a lower alkyl group of one to six carbon atoms or an optionally substituted phenyl group. Examples of "lower acyl" are acetyl, propanoyl, butanoyl and benzoyl. The term "lower alkoxyearbonylalkyl" refers to an ester group of the formula R5OC(0)- substituted on an alkyl group wherein R5 is lower alkyl as is defined above. Examples of "lower alkoxycarbonylalkyl" are methoxycarbonylmethyl, ethoxycarbonylmethyl, ethoxycarbonylethyl, n-propoxycarbonylethyl and the like. The term "heterocyclic aryl" is defined as those cyclic aromatic compounds having 3 to 9 ring carbon atoms and having one or two heteroatoms in the ring selected from the group consisting of nitrogen, oxygen and sulfur. Examples of such include the groups thiapyranyl, benzothiapyranyl, furyl, pyrrolyl, imidazolyl, pyrazolyl, pyridinyl, pyrimidinyl, indolyl, quinolinyl, indazolyl and the like. These heterocyclic aryls may be optionally substituted with halo, lower alkyl, cyano and lower alkoxy. By the term "pharmaceutically acceptable acid addition salts" as used in the case of the various R3 containing heterocyclic aryl substituents herein is intended to mean those non-toxic pharmaceutically acceptable acid addition salts which do not adversely affect the pharmaceutical properties of the parent compounds. With respect to these addition salts, suitable inorganic anions include, for example, chloride, bromide, iodide, sulfate, phosphate, nitrate, and the like. Suitable organic anions include, for example, acetate, benzoate, lactate, picrate, propionate, butyrate, valerate, tartrate, maleate, fumarate, citrate, succinate, tosylate, ascorbate, nicotinate, adipate, gluconate and the like. FORMULATION AND ADMINISTRATION The compositions of the present invention may be formulated for administration in any convenient way by analogy with other topical compositions adapted for use in mammals. These compositions may be presented for use in any conventional manner with the aid of any of a wide variety of pharmaceutical carriers or vehicles. The naphthalenes of formula (I) may be formulated with suitable pharmaceutical vehicles known in the art to form particularly effective topical compositions. An effective amount of the naphthalene compound is about 0.001%w to about 10%w of the total formulated composition. The rest of the formulated composition will be about 90%w to about 99.999%w of a suitable excipient which may include a pharmaceutically acceptable solvent and other pharmaceutically acceptable additives to form a topically effective pharmaceutical formulation. A pharmaceutically acceptable solvent is one which is substantially non-toxic and non-irritating under the conditions used and may be readily formulated into any of the classical drug formulations such as powders, creams, ointments, lotions, gels, foams, aerosols, solutions and the like. Particularly suitable solvents include water, ethanol, acetone, glycerine, propylene carbonate, dimethylsulfoxide (DMSO), and glycols such as 1,2propylene diol, i.e., propylene glycol, 1,3-propylene diol, polyethylene glycol having a molecular weight of from 100 to 10,000, dipropylene glycol, etc. and mixtures of the aforementioned solvents with each other. A topical cream may be prepared as a semi-solid emulsion of oil in water or water in oil. A cream base formulation by definition is an emulsion, which is a two-phase system with one liquid (for example fats or oils) being dispersed as small globules in another substance (e.g., a glycol-water solvent phase) which may be employed as the primary solvent for the naphthalenes therein. The cream formulation may contain fatty alcohols, surfactants, mineral oil or petrolatum and other typical pharmaceutical adjuvants such as anti-oxidants, antiseptics, or compatible adjuvants. A typical cream base formulation is as follows: Water/glycol mixture 50 - 99 parts by weight (15% or more glycol) Fatty Alcohol 1 - 20 Non-ionic Surfactant O - 10 Mineral Oil O - 10 Typical Pharmaceutical O - 5 Adjuvants Active Ingredients 0.001 - 10 The fatty alcohol, non-ionic surfactant, and other adjuvants are discussed in U.S. 3,934,013 to Poulsen which is incorporated herein by reference. The naphthalenes of formula (I) may also be formulated as topical ointments. A "classical" ointment is a semisolid anhydrous composition which may contain mineral oil, white petrolatum, a suitable solvent such as a glycol and may include propylene carbonate and other pharmaceutically suitable additives such as surfactants, for example Span and Tween, or wool fat (lanolin), along with stabilizers such as antioxidants and other adjuvants as mentioned before. Following is an example of a typical "classical" ointment base: White Petrolatum 40 - 94 parts by weight Mineral Oil 5 - 20 Glycol Solvent 1 - 15 Surfactant O - 10 Stabilizer O - 10 Active Ingredients 0.001 - 10.0 Other suitable ointment base formulations which employ propylene carbonate are described in U.S. patent 4,017,615 issued April 12, 1977 by Shastri et al entitled "Propylene Carbonate Ointment Vehicle" and U.S. 3,924,004 issued December 2, 1975 by Chang et al entitled "Fatty Alcohol-Propylene Carbonate-Glycol Solvent Cream Vehicle". As much of those applications as is pertinent is incorporated herein by reference. Following is a typical ointment base formulation containing propylene carbonate: Active Ingredients 0.001 - 10.0 parts by weight Propylene Carbonate 1 - 10 Solvent 1 - 10 Surfactant O - 10 White Petrolatum 70 - 97 Suitable solvents, surfactants, stabilizers, etc. are discussed in U.S. 3,934,013 and such are incorporated herein by reference. A suitable topical "non-classical" anhydrous, water washable "ointment type" base is described in U.S. Patent No. 3,592,930 to Katz and Neiman, and that patent is incorporated herein by reference. A representative composition of this invention utilizing such base is as follows: Glycol Solvent 40 - 35 parts by weight Fatty Alcohol 15 - 45 Compatible Plasticizer O - 15 Compatible Coupling O - 15 Agent Penetrant O - 20 Active Ingredients 0.001 - 10.0 Another aspect of the invention is a method for relieving the condition of psoriasis in a mammal by topically administering a composition containing a compound of formula (I) wherein n, R1, R2, R5, W, m and n are as defined above. Generally, the anti-psoriatic manifestation in mammals, particularly humans, is combatted by contacting the inflamed areas with a therapeutically effective amount of the naphthalene-containing compositions of this invention, that is, an amount which results in a lessening of the epidermal cell proliferation (an anti-psoriatic effect). Preferably the naphthalenes are first formulated to prepare a suitable pharmaceutical formulation, as discussed hereinabove, which is then placed in contact with the afflicted area(s). An effective amount of the naphthalene compound will depend upon the particular condition and the mammal receiving the treatment and will vary between 0.001% to 10% by weight of the pharmaceutical composition and preferably will be between 0.01% and 1% by weight of the formulation. Using these levels in the formulation, a therapeutically effective and non-side effect producing amount, i.e. enough to affect an anti-psoriatic response, but not enough to adversely effect the recipient, is applied to the afflicted area(s). A further aspect of the invention is a process for the preparation of compounds of formula (I) EMI13.1 wherein: R1 and R2 are the same and are lower alkoxy of one to six carbon atoms, lower alkylthio of one to six carbon atoms, phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; R3 is lower alkyl of one to six carbon atoms, lower alkoxy of one to six carbon atoms, or halo and m is 0, 1 or 2 or R3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, or S(O)nR wherein R is lower alkyl of one to six carbon atoms; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, phenyl or benzyl optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; with the proviso that n is not 0 or 1 when R1 and R2 are methoxy and W is methyl. Which comprises reacting a compound of the formula EMI14.1 wherein: R1, R2, R3 and m are as defined above with an acid anhydride. optionally followed by (a) converting the free compound of formula (I) wherein R3 is S(O)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano, to a pharmaceutically acceptable acid addition salt; or (b) converting a pharmaceutically acceptable acid addition salt of a compound of formula (I) wherein R3 is S(O)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano, to the free compound of formula (I) wherein R is S(O)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano; or (c) converting a pharmaceutically acceptable acid addition salt of a compound of formula (I) wherein R3 is S(O)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano, to another pharmaceutically acceptable acid salt of a compound of formula. (I) wherein R3 is S(O)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano. PREPARATION The compounds of formula (I) may be prepared from compounds of formula (V) or (VI). The intermediates of formula (V) or (VI) wherein m is 1 may be prepared by the Reaction Sequence below. Reaction Sequence I EMI16.1 wherein R1 R2 R3 are as defined above and m is 1. Compounds of formula (III) are prepared by starting with a 2,3-dihalonaphthoquinone, preferably 2,3-dichloro1,4-naphthoquinone (compound of formula (II)-), which is available from, i.a., Aldrich Chemical Co., and directly nitrating. The reaction proceeds in the manner known for polycyclic aromatic compounds to yield a mixture of the 5- and 6-nitro-2-3-dichloro-l, 4-naphthoquinones, compounds of formula (III). The reaction is conducted typically with concentrated nitric acid in a low pH solvent medium, preferably concentrated sulfuric acid, typically at 2O0C to 100 C for a time sufficient to complete the reaction. Depending on the reaction temperature and times of reaction, ratios of the 5-nitro isomer:6-nitro isomer mixture may range from 10:1 to 1:10, typically 8:1. Compounds of formula (IV) are synthesized from 5 and 6-nitro-2, 3-dichloro-l, 4-naphthoquinone, compound of formula (III), by condensing them with an alkali metal alkoxide or phenoxide, wherein the alkoxy or phenoxy moiety is R1 = R2. The reaction is preferably conducted in an inert organic solvent such as tetrahydrofuran, dimethylsulfoxide, dimethylformamide and the like at temperatures from about 2O0C to about 100C for a time sufficient to assure completeness of reaction, i.e., for about 2 hours to about 48 hours. Compounds of formula (IV) wherein R1=R2 and is lower alkylthio or phenylthio are prepared from compounds of formula (III) in the same manner as for the alkoxy or phenoxy compounds except that an alkali metal salt of an alkyl mercaptan or phenyl mercaptan is substituted for an alkali metal alkoxide or phenoxide. The compounds of formula (V) are prepared from compounds of formula (IV) by catalytic or non-catalytic reduction processes known in the prior art. Metal-acid reducing agent compositions, such as granulated iron and hydrochloric acid, tin and hydrochloric acid, and the like or neutral reducing agent compositions such as zinc dust and aqueous alcohol or aluminum amalgam and aqueous alcohol as well as organo-metallic reducing agents such as lithium aluminum hydride, sodium borohydride and the like may be used in this reduction. Preferably, the reduction is accomplished by treating the compounds of formula (IV) with excess hydrazine in the presence of a catalytically sufficient amount of palladium, typically on carbon. The reaction readily occurs at room temperature, the time of reaction being governed by the rate of addition of the hydrazine to the reaction mixture such typically being about. 1 to about 10 hours. Compounds of formula (VI) wherein R3 is hydrogen may be prepared by reacting compound of formula (Il) with an alkali metal alkoxide or phenoxide or alkali metal salt of a mercaptan as described hereinabove. Compounds of formula (VI) wherein R3 is lower alkylamino or lower dialkylamino are prepared by reacting compounds of formula (V) with an alkyl halide such as methyl iodide by methods well known in the art for alkylating amino groups. Compounds of formula (V) are converted into compounds of formula (VI) where R3 is halo by adding to the compound of formula (V) in an acidified aqueous solution, a solution of an alkali metal nitrite. This initial reaction forms the diazonium salt at the 5- or 6position of the naphthoquinone ring. The salt is decomposed with a solution of cuprous halide dispersed or dissolved in the corresponding halogen acid (the Sandmeyer reaction). Thns classical reaction is treated extensively in Bigelow, Org. Synthesis, Coll. Vol. I, 126-133 (1941). A modification of the above Sandmeyer reaction is useful in the preparation of the compounds of formula (VI) where R3 is cyano in that the diazonium salt, rather than being decomposed in the presence of cuprous halide/halogen acid is decomposed in the presence of an alkali metal cyanide and a cuprous halide. See Clarke and Read, Org. Synthesis, Coll. Vol. I, 514 (1941) for a further explanation of the considerations involved in this modified Sandmeyer reaction. The compounds of formula (VI) where R3 is an optionally substituted heterocyclic arylthio group, optionally substituted phenylthio or alkylthio may also be prepared from the diazonium salt (above). For example, the diazonium salt of the compound of formula (V) is reacted with an alkali solution of thiophenol to yield the compounds of formula (VI) where R is phenylthio. Typically, the displacement reaction of the diazonium salt is carried out at 300-750C by adding an alkali solution of thiophenol in an inert organic solvent. Solvents of preference are the inert solvents such as ethyl acetate, tetrahydrofuran and the like. Reaction times may vary from about 10 minutes to about 24 hours. The heterocyclic arylthio compounds are preferably prepared by adding the or 6-nitro-1,4-naphthoquinone compound of formula (IV) to a solution of the thiol-substituted heterocyclic aryl compound admixed with an alkali metal hydride in an inert organic solvent such as dimethylformamide. The reaction is typically conducted at -750 to -250C over a period of about 10 to about 60 minutes. The preferred procedure for the preparation of the compounds of formula (VI) where R3 is a linear or branched alkylthio or an optionally substituted phenylalkylthio is by first converting a compound of 12 formula (V) to the di(2,3-R ,R -l,4-naphthoquinone)-5 or 6-disulfide of the following formula: EMI20.1 wherein R1 and R2 are as defined above. A mixture of an alkaline earth or alkali metal thiol carboxylate such as the acetate, propanoate, butanoate and the like (compounds of the formula M(Oe(CH2)ySH), where y is the integer 0 to 18, M is an alkali or alkaline earth metal and x is the valence of said metal) in an inert organic solvent is added to a solution or dispersion of compound of formula (V) at a temperature of -10 to +100C over a period of about 1 to about 120 minutes, preferably 5 to 30 minutes. Reaction media include a variety of polar inert solvents such as dimethylformamide, dimethylsulfoxide and the like. After further reaction, typically for about 1 to about 10 hours at about 200 to about 500C, the disulfide is isolated. This compound can then be used to prepare the alkyl or phenylalkyl sulfides of formula (VI) by first treating the disulfide with sodium borohydride in an inert organic solvent and adding to such mixture at a temperature o about -10 C to about 750C for 1 to 10 hours an appropriate alkylating agent such as a dialkyl sulfate, an alkyl halide, an phenylalkyl halide and the like. Illustrative of such alkylating. agents are the compounds methyl bromide, methyl iodide, dimethyl sulfate and benzyl bromide. Preferably alkyl iodide is used as the alkylating agent herein. Where appropriate, salts of the compounds bearing heterocyclic aryl substituents are prepared. For example, the methylsulfate salt of the 2,3-dialkoxy5-(pyridin-4-ylthio)-1,4-naphthoquinone is readily prepared by admixture with dimethylsulfate in an inert organic solvent such as tetrahydrofuran. Salt formations of this type are well known in the prior art. A particularly preferred method of preparing compounds of formula (VI) wherein R is 6-halo is shown in the following reaction sequence. REACTION SEQUENCE II EMI21.1 wherein R1 and R2 are as defined above and m is 1. Compounds of formula (VIII) are prepared according to the method disclosed in J. Am. Chem. Soc., 70, 3165 (1948) and Ibid., 71, 3615 (1949). Halo substituted 1,3butadiene is reacted with 1,4-benzoquinone in a solvent such as acetic acid at a temperature of -10 C to 30 C, preferably at 250C for 24 to 72 hours, preferably from 40 to 48 hours. The 5,7-dihydro compound of formula (VIII) is recovered and treated with an oxidizing agent such as sodium dichromate, sodium nitrite and the like as described in the above articles to form compounds of formula (VIII). Compounds of formula (IX) are prepared by bubbling chlorine gas into a solution of compound of formula (VIII) in a solvent such as glacial acetic acid, nitrobenzene, carbon tetrachloride and the like, preferably glacial acetic acid at room temperature. This compound, which may be isolated by known means, dissolved in a solvent such as acetic acid is treated with chlorine gas and a suitable catalyst such as sodium acetate, iodine, iron(III)chloride, dimethylformamide or alcohols with heating under reflux for 1/2 to 4 hours, preferably for 1 to 2 1/2 hours to yield compounds of formula (X). 3 Compounds of formula (VI) wherein R is halo are prepared by reacting compound of formula (X) with an alkali metal alkoxide or phenoxide such as sodium alkoxide or phenoxide, e.g., sodium methoxide or sodium phenoxide in an anhydrous solvent such as methanol, dimethylformamide and the like, the solvent being chosen according to the length of the alkyl chain on the alkoxy group. The reaction mixture is heated under reflux for 1/2 to 3 hours, preferably for 1/2 to 1 1/2 hours. Compounds of formula (VI) are recovered by conventional means such as by crystallization. The compounds of formula (VI) wherein R1 tend R2 are lower alkylthio or phenylthio may be prepared by the method described for the alkoxy or phenoxy compound except that the alkali metal alkoxide is replaced by the alkali metal salt of the alkyl or a phenyl mercaptan with the solvent being dimethylformamide and the like. The intermediate, 2-chloro-1,3-butadiene (chloroprene) is available from, i.a., Pfaltz and Bauer Chemical Co. 2-Bromo-l,3-butadiene and 2-fluoro-1,3-butadiene may be prepared by methods well known in the art, for example, by the methods discussed in J. Am. Chem. Soc., 55 786 (1933) and U. S. Patent No. 2,401,850, respectively. The intermediates of formula (Vl) wherein R 3is lower alkyl, lower alkoxy, optionally substituted phenyl, optionally substituted phenyl lower alkyl or optionally substituted phenyl lower alkoxy may be prepared by methods well known in the art such as by reacting the diazonium salt of compound of formula (V) with an appropriate compound such as an alcohol e.g. methanol, ethanol, benzyl alcohol and the like. These intermediates may also be prepared by the method set out in Reaction Sequence (II) wherein the 2-halo-l,3-butadiene is replaced by the appropriate 1,3-butadiene such as 2-methyl-1,3-butadiene(isoprene), 2-ethyl-1,3-butadiene, 2,3-dimethyl-1,3-butadiene and the like. Compounds of formula (I) are prepared from compounds of formula (VI) by first hydrogenating to form compounds of formula (XI) EMI23.1 in a hydrogen atmosphere in the presence of a catalyst such as palladium on charcoal and then reacting the hydrogenated compound with an appropriate anhydride and pyridine such as acetic anhydride, benzoic acid anhydride and the like in a solvent such as tetrahydrofuran, diethyl ether and the like. Compounds of formula (I) are recovered by crystallization. The acid anhydrides are commercially available from, i.a., Aldrich Chemical Co. or if not available may be prepared by condensing the appropriate acid in the presence of acetic anhydride or acetyl chloride containing a trace of phosphoric acid. The anhydride is recovered by distillation or crystallization. The sulfinylnaphthalenes of formula (I) are prepared by oxidation of the corresponding thio compounds with a stoichiometric amount of a suitable peracid in an inert organic solvent. The compounds of formula (I) bearing a sulfonyl substituent are prepared by further oxidizing the compounds of formula (I) wherein R3 is a sulfinyl group with a suitable peracid typically at -10 to 75OC for 1 to 10 hours. Preferably, m-chloroperbenzoic acid in an inert organic solvent at room temperature is used to prepare the desired sulfonyl compounds. The following specific description is given to enable those skilled in the art to more clearly understand and practice the present invention. It should not be considered as a limitation upon the scope of the invention but merely as illustrative and representative thereof. Preparation 1 2,3-D hloro-5- and 6-nitro-1,4-naphthoquinone. (Preparation of Compounds of Formula (III)). Finely powdered 2,3-dichloro-1,4-naphthoquinone (50 g. 0.22 mol) was added to a stirred mixture of concentrated sulfuric acid (170 ml) and 90% nitric acid (102 ml) at a rate so that the exothermic reaction raised the temperature to 600C. The resulting mixture was stirred at 6O0C for a further 2 hours. The yellow crystalline solid was filtered off, washed thoroughly with water and recrystallized from chloroform giving 22.9 g of the 5-nitro isomer, mp 156-1570C. The above strongly acidic filtrate was poured onto ice water. The resultant solid was filtered off, washed thoroughly with water and dried giving 20.8 g of a mixture of the 5- and 6-isomer. Fractional crystallization of this mixture from acetic acid and chloroform:isopropanol afforded 2.8 g of the 6-nitro isomer, mp 184-1870C. Further quantities of both 5- and 6-isomer were obtained from the recrystallization mother liquors by chromatography on a silica gel column eluting with chloroform:cyclohexane mixtures. Preparation 2 2,3-Dimethoxy-5-nitro-1,4-naphthoquinone (Preparation of Compounds of Formula (IV)). A. A solution of 2,3-dichloro-5-nitro-1,4-naphthoquinone (2.72 g, 10 mmol) in anhydrous tetrahydrofuran (15 ml) was added to a solution of 1 N sodium methoxide (25 ml, 25 mmol) and the resulting solution stored at 220 for 16 hours. Acetic acid (1 ml) was then added, the solution concentrated in vacuo and the residue partitioned between water (50 ml) and chloroform (100 ml). The aqueous phase was further extracted with chloroform (2 x 50 ml). The combined chloroform extracts were dried with MgS04 and concentrated in vacuo. The residue was recrystallized from methanol giving 1.99 g of 2,3-dimethoxy-5-nitro-1,4-naphthoquinone, mp 156-157 . B. Similarly, using the above procedure in Part A, substituting 2,3-dichloro-6-nitro-1,4-naphthoquinone, where appropriate, for 2,3-dichloro-5-nitro 1,4-naphthoquinone and the appropriate sodium alkoxide or sodium phenoxide for sodium methoxide, the following compounds are prepared: : 2,3-dimethoxy-6-nitro-1,4-naphthoquinone, mp 113-1140C; 2,3-diethoxy-5-nitro-1,4-naphthoquinone; 2,3-diethoxy-6-nitro-1,4-naphthoquinone; 2,3-din-n-propoxy-5-nitro-1,4-naphthoquinone; 2,3-din-n-propoxy-6-nitro-1,4-naphthoquinone; 2,3-din-i-propoxy-5-nitro-1,4-naphthoquinone; 2,3-din-i-propoxy-6-nitro-1,4-naphthoquinone; 2,3-din-n-propoxy-5-nitro-1,4-naphthoquinone 2, 3-di-n-butoxy-6-nitro-l , 4-naphthoquinone; 2,3-di-s-butoxy-5-nitro-1,4-naphthoquinone; 2, 3-di-s-butoxy-6-nitro-l,4-naphthoquinone; 2,3-di-n-pentyloxy-5-nitro-1,4-naphthoquinone; 2,3-di-n-pentyloxy-6-nitro-l,4-naphthoquinone; 2,3-di-s-pentyloxy-5-nitro-1,4-naphthoquinone; 2,3-di-s-pentyloxy-6-nitro-1,4-naphthoquinone; 2,3-di-n-hexyloxy-5-nitro-1,4-naphthoquinone; 2,3-di-n-hexyloxy-6-nitro-1,4-naphthoquinone; ; 2,3-di-i-hexyloxy-5-nitro-1,4-naphthoquinone; 2,3-di-i-hexyloxy-6-nitro-1,4-naphthoquinone; 2,3-di(2,2-dimethylpropoxy)-5-nitro-1,4- naphthoquinone; 2,3-di(2,2-dimethyipropoxy)-6-nitro-1,4- naphthoquinone; 2,3-diphenoxy-6-nitro-1,4-naphthoquinone; 2,3-di(4-chlorophenoxy)-6-nitro-1,4-naphthoquinone; 2,3-diphenoxy-5-nitro-1,4-naphthoquinone; 2,3-di(4-methoxyphenoxy)-6-nitro-1,4-naphthoquinone; 2,3-di(2,4-dichlorophenoxy)-6-nitro 1,4-naphthoquinone; and 2,3-di(3-methylphenoxy)-6-nitro-1,4-naphthoquinone. C. Similarly, using the above procedure in Part A, substituting 2,3-dichloro-6-nitro-1,4-naphthoquinone, where appropriate, for 2,3-dichloro-5-nitro-1,4-naphthoquinone and the appropriate sodium salt of alkylmeracaptan or phenylmercaptan for sodium methoxide or sodium phenoxide, the following compounds, for example, are prepared: 2,3-dimethylthio-6-nitro-1,4-naphthoquinone; 2,3-di-i-propylthio-6-nitro-1,4-naphthoquinone; 2,3-di-n-hexylthio-6-nitro-1,4-naphthoquinone; 2,3-di(4-chlorophenylthio)-6-nitro-1,4-naphthoQuinone; 2,3-diphenylthio-6-nitro-1,4-naphthoquinone; and 2,3-diphenylthio-5-nitro-1,4-naphthoquinone. Preparation 3 2, 3-Dimethoxy-5-amino-l , 4-naphthoquinone. (Preparation of Compounds of Formula (V)). Hydrazine (4.0 ml, 125 mmol of 97%) was added dropwise, over a 2 hour period, to a stirred mixture of the captioned compound of Preparation 2 (19.9 g, 75.6 mmol), 5% palladium on carbon (10 g) and ethanol (750 ml) in a nitrogen atmosphere. The catalyst was filtered off through a celite pad that was washed with hot ethanol (2 x 300 ml). The combined filtrate and washings were concentrated to dryness in vacuo and the residue recrystallized from water:ethanol (1.5:1) giving 14.6 g of 2,3-dimethoxy-5-amino-1,4-naphthoquinone mp 116-1170. Similarly, substituting the compounds from Preparation 2 for 2,3-dimethoxy-5-nitro-1,4- naphthoquinone the following compounds are prepared: 2,3-dimethoxy-6-amino-1,4-naphthoquinone, mp 196-1970C; 2,3-diethoxy-5-amino-1,4-naphthoquinone; 2,3-diethoxy-6-amino-1,4-naphthoquinone; 2,3-di-n-propoxy-5-amino-1,4-naphthoquinone; 2,3-di-n-propoxy-6-amino-1,4-naphthoquinone; 2, 3-di-i-propoxy-5-amino-l, 4-naphthoquinone; 2,3-di-i-propoxy-6-amino-1,4-naphthoquinone; 2,3-di-n-butoxy-5-amino-1,4-naphthoquinone; 2,3-di-n-butoxy-6-amino-1,4-naphthoquinone; 2,3-di-s-butoxy-5-amino-1,4-naphthoquinone; 2,3-di-s-butoxy-6-amino-1,4-naphthoquinone; 2,3-di-n-pentyloxy-5-amino-1,4-naphthoquinone; 2,3-di-n-pentyloxy-6-amino-1,4-naphthoquinone; ; 2,3-di-s-pentyloxy-5-amino-1,4-naphthoquinone; 2,3-di-s-pentyloxy-6-amino-1,4-naphthoquinone; 2,3-di-n-hexyloxy-5-amino-1,4-naphthoquinone; 2,3-di-n-hexyloxy-6-amino-1,4-naphthoquinone; 2,3-di-i-hexloxy-5-amino-1,4-naphthoquinone; 2,3-di-i-hexloxy-6-amino-1,4-naphthoquinone; 2,3-di(2,2-dimethylpropoxy)-5-amino-1,4- naphthoquinone; 2,3-di(2,2-dimethylpropoxy)-6-amino-1,4- naphthoquinone; 2, 3-dimethylthio-6-amino-l, 4-naphthoquinone; 2,3-di-i-propylthio-6-amino-1,4-naphthoquinone; 2,3-di-n-hexylthio-6-amino-1,4-naphthoquinone; 2,3-diphenoxy-6-amino-1,4-naphthoquinone; 2,3-di(4-chlorophenoxy)-6-amino-1,4-naphthoquinone; 2,3-di(4-methoxyphenoxy)-6-amino-1,4-naphthoquinone; 2,3-di(2,4-dichlorophenoxy)-6-amino1,4-naphthoquinone; and 2,3-di(3-methylphenoxy)-6-amino-1,4-naphthoquinone. Preparatior 4 5-Chloro-2, 3-dimethoxy-l, 4-naphthoguinone. (Preparation of Compounds of Formula (VI) where R3 is 5-chloro). A solution of sodium nitrite (0.69 g, 10 mmol) in water (5 ml) was added at 0-50C to a solution of 5-amino-2,3-dimethoxy-1,4-naphthoquinone (1.17 g, 5 mmol) in 5:1 acetic acid:water (25 ml) containing concentrated hydrochloric acid (1.7 ml). A further quantity of sodium nitrite (0.69 g) was then added to the reaction mixture after cooling to -50C, followed by a solution of cuprous chloride (0.6 g) in concentrated hydrochloric acid (5 ml). The mixture was allowed to warm to 22 C and solid cuprous chloride was added portionwise until the mixture assumed a green color. Water was then added to the reaction mixture and the precipitated yellow solid filtered off, washed with water and recrystallized from methanol:water (2:1) giving 1.01 g of 5-chloro 2,3-dimethoxy-1,4-naphthoquinone, mp 120-1210C. Similarly, proceeding as above substituting the appropriate compounds for 2,3-dimethoxy-5-amino-1,4- naphthoquinone the following compounds are prepared: 6-chloro-2, 3-dimethoxy-l, 4-naphthoquinone; 5-chloro-2,3-diethoxy-1,4-naphthoquinone; 6-chloro-2,3-diethoxy-1,4-naphthoquinone; 5-chloro-2,3-di-n-propoxy-1,4-naphthoquinone; 6-chloro-2,3-di-n-propoxy-1,4-naphthoquinone; 5-chloro-2,3-di-i-propoxy-1,4-naphthoquinone; 6-chloro-2, 3-di-i-propoxy-l, 4-naphthoquinone; 5-chloro-2,3-di-n-butoxy-1,4-naphthoquinone; 6-chloro-2, 3-di-n-butoxy-l, 4-naphthoquinone; 5-chloro-2,3-di-s-butoxy-1,4-naphthoquinone; 6-chloro-2,3-di-s-butoxy-1,4-naphthoquinone; 5-chloro-2,3-di-n-pentyloxy-1,4-naphsthoquinone; 6-chloro-2,3-di-n-pentyloxy-1,4-naphthoquinone; ; 5-chloro-2,3-di-s-pentyloxy-1,4-naphthoquinone; 6-chloro-2,3-di-s-pentyloxy-1,4-naphthoquinone; 5-chloro-2,3-di-n-hexyloxy-1,4-naphthoquinone; 6-chloro-2,3-di-n-hexyloxy-1,4-naphthoquinone; 5-chloro-2,3-di-i-hexyloxy-1,4-naphthoquinone; 6-chloro-2,3-di-i-hexyloxy-1,4-naphthoquinone; 5-chloro-2,3-di(2,2-dimethylpropoxy)-1,4naphthoquinone; 6-chloro-2,3-di(2,2-dimethylpropoxy)-1,4 naphthoquinone; 5-methoxy-2,3-dimethoxy-1,4-naphthoquinone; 6-methoxy-2,3-dimethoxy-1,4-naphthoquinone; 6-ethoxy-2,3-diethoxy-1,4-naphthoquinone; 6-i-butoxy-2,3-dimethoxy-1,4-naphthoquinone; 6-phenylethoxy-2,3-dimethoxy-1,4-naphthoquinone; 6-chloro-2,3-dimethylthio-1,4-naphthoquinone; 6-chloro-2,3-di-i-propylthio-1,4-naphthyloqinone; ; and 6-chloro-2,3-di-n-hexylthio-1,4-naphthyloqinone; 6-chloro-2, 3-diphenoxy-l , 4-naphthoquinone; 6-chloro-2,3-di(4-chlorophenoxy)-1,4-naphthoquinone; 6-chloro-2,3-di(4-methoxyphenoxy)-1,4-naphthoquinone; 6-chloro-2,3-di(2,4-dichlorophenoxy)1,4-naphthoquinone; and 6-chloro-2,3-di(3-methylphenoxy)-1,4-naphthoquinone. Preparation 5 5-Cyano-2,3-dimethoxy-1,4-naphthoquinone. 3 (Preparation of Compounds of Formula (VI) where R is cyano). A solution of sodium nitrite (2.21 g, 32 mmol) in water (6 ml) was added at 0-5 C to a stirred suspension of 5-amino-2,3-dimethoxy-1,4-naphthoquinone (3.73 g, 16 mmol) in 3:1 water:tetrahydrofuran (20 ml) containing concentrated hydrochloric acid (6.7 ml) and the resulting mixture was stirred at 0-50C for a further 1.1/4 hour. The almost clear solution is then neutralized with sodium carbonate, filtered and added at 50C to a vigorously stirred solution of cuprous chloride (4.75 g) and sodium cyanide (5.88 g) in water (80 ml). Ethyl acetate (100 ml) was added and the mixture is heated at 450C for 0.5 hours, filtered through a celite bed and separated into the two phases. The aqueous phase was extracted with ethyl acetate (2x 100 ml). The combined organic phases were extracted with brine (150 ml), dried over MISS04 and concentrated to dryness in vacuo. The residue was recrystallized from isopropanol giving 2.96 g of 5-cyano-2,3-dimethoxy-1,4-naphthoquinone, mp 171-1720C. Similarly, proceeding as above the following compound is prepared: 6-cyano-2, 3-dimethoxy-l, 4-naphthoquinone. Preparation 6 Di-(2,3-dimethoxy-l,4-naphthoquinone-5)-disulfide. (Preparation of Compounds of Formula (VII)). A slurry of potassium thiolacetate (1.5 g, 13.1 mmol) in dimethylformamide (25 ml) was added over 10 minutes to a solution at 0-50C of 5-amino-2,3-dimethoxy1,4-naphthoquinone (2.63 g, 10 mmol) in dimethylformamide (25 ml). The mixture was allowed to warm to 220C and, after 2 hours, an additional quantity of potassium thiolacetate (1.25 g) was added. After a further 45 minute reaction, the mixture was added to ice water (500 ml) that was adjusted to pH 6 with acetic acid. The precipitated solid was filtered off, washed with water and recrystallized from chloroform:methanol (1:1) giving 1.32 g. of di(2,3-dimethoxy-1,4-naphthoquinone-5)- disulfide, mp 220-2210C. Preparation 7 2, 3-Dimethoxy-5-phenylthio-l, 4-naphthoqui one. (Preparation of Compounds of Formula (VI) where w is phenylthio). Method A. Sodium nitrite (0.18 g) was added at 0-50C to a stirred suspension of 5-amino-2,3-dimethoxy 1,4-naphthoquinone (233 mg, 1 mmol) in 0.6 N hydrochloric acid (10 ml) and tetrahydrofuran (1 ml). The mixture was stirred at 50C for 10 minutes until a clear solution was obtained and was then neutralized by the addition of sodium carbonate. The ice cold solution was then slowly added to a vigorously stirred two-phase mixture in a nitrogen atmosphere at 500C composed of potassium hydroxide (0.16 g), water (10 ml), thiophenol (0.32 ml) and ethyl acetate (35 ml). After a total reaction time of 20 min, the mixture was partitioned between ethyl acetate (40 ml) and brine (100 ml). The ethyl acetate phase was dried over MISS04 and concentrated in vacuo. The residue was purified by chromatography on a thick layer silica gel plate using acetone:toluene:chloroform (1:20:20) giving a solid that, after recrystallizing from isopropanol, afforded 70 mg of 2,3-dimethoxy-5phenylthio-1,4-naphthoquinone, mp 76-770C. Similarly, using imidazolyl-2-thiol in place of thiophenol, 2,3-dimethoxy-5-(imidazol-2-yl)thio-1,4- naphthoquinone, mp 97-100 C, was prepared. Method B. Thiophenol (6.0 ml, 59 mmol) was added at -30 C to a stirred mixture of 100% sodium hydride (1.4 g, 59 mmol) and dimethylformamide (200 ml) and the resulting mixture was stirred at 220C for 16 hours. This mixture was then cooled to -50 C and a solution of di(2,3-dimethoxy-l,4-naphthoquinone-5)-disulfide (13.0 g, 49 mmol) in dimethylformamide (100 ml) was added over 30 min. The resulting mixture was allowed to warm to 220C over 1 hour before being cooled to -500C and neutralized with acetic acid (5.4 ml, 90 mmol). The reaction mixture wa then poured into a mixture of water (1.8 1) and methanol (700 ml). The precipitated material was filtered off and recrystallized from methanol giving 10.3 g of 2,3-dimethoxy-5-phenylthio-1,4-naphthoquinone, mp 76-790C. A further amount (2.2 g) mp 76-770C was obtained in a second crop from the recrystallization. Similarly, substituting of the appropriate thiol for thiophenol and the appropriate compound from Preparation 3, the following compounds are prepared: 2,3-dimethoxy-6-(2-chlorophenylthio)-1,4-naphtho- quinone; 2,3-dimethoxy-5-(3-chlorophenylthio)-1,4-naphtho- quinone, mp 125-1260C; 2,3-dimethoxy-6-(4-chlorophenylthio)-1,4-naphthoquinone; 2,5-dimethoxy-5-(2,6-dichlorophenylthio)-1,4-naphtho- quinone, mp 158-1590C; 2,3-dimethoxy-5-(4-fluorophenylthio)-1,4-naphtho- quinone, mp 124-1250C; 2,3-dimethoxy-5-(2-bromophenylthio)-1,4-naphtho- quinone, mp 152-1530C; 2,3-dimethoxy-6-(4-bromophenylthio)-1,4-naphthoquinone; 2,3-diethoxy-6-(4-methoxyphenylthio)-1,4-naphthoquinone; ; 2,3-di-n-propoxy-6-(4-nitrophenylthio)-1,4-naphtho- quinone; 2,3-di-n-butoxy-6-(2-ethylphenylthio)-l,4-naphthoquinone; 2,3-di-n-pentyloxy-6-pyridin-2-ylthio-1,4-naphtho- quinone; 2,3-di-n-hexyloxy-6-pyridin-4-ylthio-1,4-naphtho- quinone; and 2,3-dimethoxy-5-(4-acetylaminophenylthio)1,4-naphthoquinone, mp 118-1270C. Preparation 8 2,3-Dimethoxy-5-methylthio-1,4-naphthoquinone. (Preparation of Compounds of Formula (VI) where R3 is methylthio). Sodium borohydride (100 mg) was added portionwise to a stirred suspension of di(2,3-dimethoxy-1,4-naphthoquinone-5)-disulfide (0.5 g, 1 mmol) in 7:1 tetrahydrofuran:isopropanol (40 ml) in a nitrogen atmosphere until TLC analysis indicated that no starting material remains. Methyl iodide (0.2 ml) was then added and, after 5 minutes, the reaction mixture was poured into ice water (300 ml). 10% Ferric chloride (10 ml) was subsequently added. The precipitated solid was filtered off, washed with water and recrystallized from isopropanol giving 0.36 g of 2,3-dimethoxy-5-methylthio1,4-naphthoquinone, mp 112-1130C. By substituting other alkyl iodides for methyl iodide the following are prepared; 2,3-dimethoxy-6-methylthio-1,4-naphthoquinone; 2,3-dimethoxy-5-benzylthio-1,4-naphthoquinone, m.p. l42-l430C; 2, 3-dimethoxy-6-ethylthio-l, 4-naphthoquinone; and 2,3-dimethoxy-5-methoxycarbonylmethylthio-1,4- naphthoquinone, m.p. 119-1200C. Preparation 9 2,3-Dimethoxy-5-(4-methylpyridiniumthio)-1,4-naphtho quinone methyl sulfate. A mixture of dimethylsulfate (0.19 ml, 2 mmol) and 2, 3-dimethoxy-5-( 4-methylpyridinylthio) -1, 4-naphthoquinone (327 pg, 1 mmo') in tetrahydrofuran (10 ml) was heated under reflux for 3 hours and then cooled to 200C. The orange solid was filtered off, washed with tetrahydrofuran and recrystallized from ethanol:isopropanol giving 279 mg of 2,3-dimethoxy-5-(4-methylpyridiniumthio)-1,4-naphtho- quinone methyl sulfate mp 160-1620C and a second crop of 110 mg. Similarly prepared is 2,3-dimethoxy-5-(2-methylpyridiniumthio)-1,4-naphthoquinone methyl sulfate. Similarly, the following compounds are prepared by the above method: 2,3-dimethoxy-5-(2-methylpyridiniumsulfinyl)1,4-naphthoquinone methyl sulfate, m.p. 175 - 1760C; and 2, 3-diemthoxy-5-( 4-methylpyridiniumsulfinyl) - 1,4-naphthoquinone methyl sulfate, m.p. 175 - 1760C. Preparation 10 (Preparation of compounds of formula (X) wherein 3 R is 6-chloro) Method A; Into a solution of 6-chloro1,4-naphthoquinone (193 g) in glacial acetic acid (1600 mL) was bubbled chlorine gas until TLC of an aliquot showed complete disappearance of 6-chloro l,4-naphthoquinone. The resulting precipitate was collected by filtration, and washed with acetic acid (200 mL) and hexane (2 X 300 mL) and air dried to yield the 2,3,6-trichloro-2,3-dihydro-l,4-naphthoquinone (157 g). The solid was transferred into a flask equipped with a mechanical stirrer and reflux condenser. Sodium acetate (98.4 g) and acetic acid (1.5 L) were added, and into the suspension was bubbled chlorine gas. The mixture was brought to reflux and maintained there for 2 hours. The cooled mixture was poured over water (3.5 L), and the resulting precipitate was collected by filtration, and was washed with water (2 x 500 mL), air dried and then vacuum dried over phosphorus pentoxide, to yield 2,3,6-trichloro-1,4-naphthoquinone (139 g), mp 147.5-148.50C. Method B: Into a suspension of 6-chloro-1,4-naphthoquinone (100 g) in acetic acid (800 mL) heated to 700C with mechanical stirring was bubbled chlorine gas. Heating was increased to bring the mixture to reflux, at which time solid iodine (13.2 g) was added. Chlorine addition at reflux was continued until TLC showed complete conversion to product, 7-10 hours total. The reaction was cooled to give a thick precipitate of 2,3,6-trichloro-1,4-naphthoquinone collected by filtration. A second crop was obtained by concentratin and/or dilution with water. Total yield of dried product was 121.2 g, mp 147.50-l48.30C. Similarly, using either of the above procedures, the following compounds, for example, are prepared: 6-bromo-2,3-dichloro-1,4-naphthoquinone; 6-fluoro-2,3-dichloro-1,4-naphthoquinone; 6-methyl-2,3-dichloro-1,4-naphthoquinone; 6-i-propyl-2,3-dichloro-1,4-naphthoquinone; 6-phenyl-2,3-dichloro-1,4-naphthoquinone; and 6-benzyl-2,3-dichloro-1,4-naphthoquinone Preparation 11 (Preparation of compounds of formula (VI) wherein R3 is 6-chloro) To a mechanically stirred solution of sodium methoxide (55.5 g) in anhydrous methanol (1.5 L) under a blanket of nitrogen was added 2,3,6-trichloro-1,4-naphtho- quinone from Preparation 10 (130 g) as rapidly as possible. The temperature rose to 500C during the addition, and the reaction was then heated to reflux for 1 hour. The mixture was ooled and acidified with 6M hydrochloric acid to give a brilliant yellow color. After the addition of water (300 mL), the reaction mixture was filtered, and the precipitate was washed with aqueous methanol (4:1 water-methanol) until the filtrate was yellow-orange. The precipitate was air dried to yield 6-chloro-2,3-dimethoxy-1,4-naphthoquinone (102 g), mp 125-126 C. Similarly, using the above procedure, the following compounds are prepared: 6-bromo-2,3-dimethoxy-1,4-naphthoquinone; 6-fluoro-2,3-dimethoxy-1,4-naphthoquinone; 6-chloro-2,3-diethoxy-1,4-naphthoquinone; 6-methyl-2, 3-dimethoxy-l, 4-naphthoquinone; 6-i-propyl-2,3-dimethoxy-1,4-naphthoquinone; 6-phenyl-2, 3-dimethoxy-l, 4-naphthoquinone; and 6-benzyl-2,3-dimethoxy-1,4-naphthoquinone. Preparation 12 A. To a solution of sodium-n-butoxide (25.8 g) in dry dimethylformamide (125 ml) was added 2,3,6-trichloro1,4-naphthoquinone (28 g) in one amount. The mixture was refluxed for 2 hours, then cooled, acidified with 6M hydrochloric acid and evaporated. The residue was chromatographed over silica gel using dichloromethane as eluant to yield 2,3-di-n-butyloxy-6-chloro-1,4- naphthoquinone (12.3 g) as a red oily solid. B. Similarly, proceeding as above in Part A, substituting the appropriate compound for 2,3,6-trichloro-1,4-naphthoquinone and the appropriate sodium alkoxide or sodium phenoxide for sodium-n-butoxide, the following compounds are prepared: 6-chloro-2,3-di-i-butoxy-1,4-naphthoquinone; 6-chloro-2,3-(2,2-dimethylpropoxy)1,4-naphthoquinone; 2,3-di-s-butoxy-1,4-naphthoquinone; 2,3-di(2,2-dimethylpropoxy)-l,4-naphthoquinone; 2,3-di-n-hexyloxy-l,4-naphthoquinone; 2,3-diphenoxy-1,4-naphthoquinone; 6-chloro-2, 3-diphenoxy-l , 4-naphthoquinone; 6-chloro-2,3-di(4-ethylphenoxy)-1,4-naphthoquinone; 6-chloro-2,3-di(2-fluorophenoxy)-l,4-naphthoquinone; 6-chloro-2,3-di(4-t-butylphenoxy)-1,4-naphthoquinone; ; 6-chloro-2,3-di(2,6-dimethylphenoxy)1,4-naphthoquinone; and 6-chloro-2,3-di(2-ethoxyphenoxy)-1,4-naphthoquinone. C. Similarly, proceeding as above in Part A, substituting the appropriate alkali metal salt of alkyl or phenyl mercaptan for sodium-n-butoxide, the following compounds, for example, are prepared: 6-chloro-2,3-dimethylthio-1,4-naphthoquinone; 6-chloro-2,3-di-i-propylthio-1,4-naphthoquinone; 6-chloro-2, 3-di-n-hexylthio-l, 4-naphthoquinone; 2,3-dimethylthio-1,4-naphthoquinone; 2,3-diphenylthio-1,4-naphthoquinone; 6-chloro-2,3-diphenylthio-1,4-naphthoquinone; and 6-chloro-2,3-di(4-chlorophenylthio)1,4-naphthoquinone. Preparation 13 (Compound of formula (VI) wherein R3 is hydrogen) To a mechanically stirred solution of sodium methoxide (11.1 g) in anhydrous methanol (200 mL) under a blanket of nitrogen was added 2,3-dichloro-1,4naphthoquinone (22.7 g) as rapidly as possible. The temperature rose to 500C during the addition, and the reaction was then heated to reflux for 1 hour. The mixture was cooled and acidified with 6M hydrochloric acid to give a brilliant yellow color. After the addition of water (800 mL), the reaction mixture was filtered, and the precipitate was washed with aqueous methanol (4:1 water-methaool) until the filtrate was yellow-orange. The precipitate was air dried to yield 21.2 g of 2,3-dimethoxy-1,4-naphthoquinone, m.p. 116-1170C. Similarly, substituting the appropriate sodium alkoxide for sodium methoxide the following compounds are prepared. 2,3-diethoxy-1,4-naphthoquinone; 2,3-di-n-propoxy-1,4-naphthoquinone; EXAMPLE 1 A. A solution of 6-chloro-2,3-dimethoxy-1,4-naphtho- quinone (50.5 g, 200 mmol) in tetrahydrofuran (500 mL) was hydrogenated at atmospheric prssure over palladium-on-charcoal (10%, 5.0 g) until the solution was colorless, approximately 4 hours. B. While still under a blanket of hydrogen, a solution of acetic anhydride (47 mL) pyridine (40 mL) and DMAP (1.22 g) in tetrahydrofuran (50 mL) was added to the mixture. After stirring for 1 hour, the mixture was filtered and evaporated. The residue was dissolved in ether (500 mL) and was washed with 1M HC1 (3 x 250 mL) and with brine (2 x 250 mL). The organic layer was dried over sodium sulfate, filtered, and evaporated to give an oil which crystallized at high vacuum. Recrystallization from ether-petroleum ether afforded 6-chloro l,4-diacetyloxy-2,3-dimethoxynaphthalene, m.p. 93-94 C. Similarly, using the above procedure substituting the appropriate compound of formula (VI) for 6-chloro 2,3-dimethoxy-l,4-naphthoquinone, where appropriate, and the appropriate acid anhydride for acetic anhydride, where appropriate, the following compounds are prepared: 6,7-dimethyl-2,3-dimethoxy-1,4-di-acetyloxynaphthalene, m.p. 1240-1250C; 6,7-dimethyl-2,3-dimethoxy-1,4-di-n-propanoyloxy- naphthalene, m.p. 1080-1090C; 6,7-dimethyl-2,3-dimethoxy-1,4-di-n-butanoyloxy- naphthalene, m.p. 690-700C; 6,7-dimethyl-2,3-dimethoxy-1,4-di-i-butanoyloxy- naphthalene, m.p. 980-990C; 6,7-dimethyl-2,3-dimethoxy-1,4-di(2,2-dimethylpropanyloxy)naphthalene, m.p. 1240-1250C; ; 2, 3-dimethoxy-l, 4-dibenzoyloxynaphthalene; 6-chloro-2,3-dimethoxy-1,4-dibenzoyloxynaphthalene; m.p. 1610-1620C. 6-chloro-2,3-diethoxy-1,4-di(2-chlorobenzoyloxy)naphthalene; 6-chloro-2,3-diethoxy-1,4-di(3-chlorobenzoyloxy)naphthalene; 6-chloro-2,3-di-n-propoxy-1,4-di(4-ethylbenzoylOxy)- naphthalene; 6-chloro-2,3-di-n-propoxy-1,4-di(4-fluorobenzoylOxy)- naphthalene; 6-chloro-2,3-diethoxy-1,4-di(2-methoxybenzoyloxy)- naphthalene; 6-chloro-2,3-diethoxy-1,4-di(4-chlorobenzoyloxy)naphthalene; 6-chloro-2,3-di-n-butyloxy-1,4-di(2,4-dichloro- benzoyloxy)naphthalene; 6-chloro-2,3-di-n-butyloxy-1,4-di(3,5-dichloro- benzoyloxy)naphthalene; 6-chloro-2,3-dimethoxy-1,4-di(2,6-dimethylbenzoyloxy)naphthalene; 2,3-dimethoxy-1,4-diphenylacetyloxynaphthalene; 6-chloro-2, 3-dimethoxy-l, 4-diphenylacetyloxy- naphthalene; ; 6-chloro-2,3-diethoxy-1,4-di(2-chlorophenylacetyloxynaphthalene; 6-chloro-2,3-diethoxy-1,4-di( fluorophenylacetyloxynaphthalene; 6-chloro-2,3-di-n-propoxy-1,4-di(2-methoxyphenylacetyloxy)naphthalene; 6-chloro-2,3-di-n-propoxy-1,4-di(4-methoxyphenylacetyloxy)naphthalene; 6-chloro-2,3-di-n-propoxy-1,4-di(4-ethoxyphenylacetyloxy)naphthalene; 6-chloro-2,3-dimethoxy-1,4-di(2-methylphenylacetyloxy)naphthalene; 6-chloro-2,3-dimethoxy-1,4-di(4-ethylphenylacetyloxy)naphthalene; 2,3-dihenoxy-1,4-diacetyloxynaphthalene, m.p. 242-2430C; 2,3-diphenoxy-1,4-di-n-propanoyloxynaphthalene, m.p. 164-1650C; 2,3-diphenoxy-1,4-di-(2,2-dimethylpropanoyloxy)- naphthalene, m.p. 218-2190C; 2,3-diphenoxy-1,4-dibenzoyloxynaphthalene, m.p. 201-2020C; 6-chloro-2,3-diphenoxy-1,4-dibenzoyloxynaphthalene, m.p. 1730-1740C. 6-chloro-2,3-diphenoxy-1,4-diacetyloxynaphthalene; m.p. 1440-1450C. 6-chloro-2,3-di(2-chlorophenoxy)-1,4-dibenzoyloxynaphthalene; 6-chloro-2,3-diphenoxy-1,4-di-n-propanoyloxynaphthalene, m.p. 136 -137 c. 6-chloro-2,3-diphenoxy-1,4-di-n-butanoyloxynaphthalene, m.p. 1090-1100C. 6-chloro-2, 3-diphenoxy-l, 4-di(2, 2-dimethyl- propanoyloxy)naphthalene, m.p. 164-1650C; 6-chloro-2,3-diphenoxy-1,4-di-i-butanoyl oxynaphthalene, m.p. 116-1170C; 6-chloro-2h3-di(4-chlorophenoxy)-1,4-di(4-benzOylOxy- naphthalene; 6-chloro-2,3-di(4-methoxyphenoxy)-1,4-diphenylacetyloxynaphthalene; 6-chloro-2,3-di(2,4-dichlorophenoxy)-1,4-diphenylacetyloxynaphthalene; 6-chloro-2, 3-di(3-methylphenoxy)-l,4-diacetyloxy- naphthalene; 6-chloro-2,3-di(4-ethylphenoxy)-1,4-dibenzyloxy- naphthalene; and 6-chloro-2,3-di(2-fluorophenoxy)-l,4-di(2-methyl- benzoyloxy ) naphthalene. EXAMPLE 2 To a solution of 6-chloro-2,3-dimethylthio1,4-naphthoquinone (2.0 g) in tetrahydrofuran (150 ml) was added palladium on carbon (10%, 2.0 g), followed by 1,4-cyclohexadiene (11.3 g). After stirring overnight, the mixture was treated with acetic anhydride (7.2 ml) pyridine (5.5 ml) and dimethylaminopyridine (0.1 g). The mixture was filtered through celite. The residue was dissolved in ether (500 mL) and was washed with 1M HC1 (3 x 250 mL) and with brine (2 x 250 mL). The organic layer was dried over sodium sulfate, filtered, and evaporated to give an oil which crystallized at high vacuum. Recrystallization of the product gave 6-chloro 2,3-dimethylthio-1,4-diacetoxynaphthalene, m.p. 1130-140C. Similarly proceeding as above, substituting the appropriate compound for 6-chloro-2,3-dimethylthio1,4-naphthoquinone and the appropriate acid anhydride, where appropriate, for acetic anhydride the following compounds are prepared: 2,3-dimethylthio-1,4-di(4-ethylbenzoyloxy)naphthalene; 2,3-dimethylthio-1,4-di(2-methylbenzoyloxy)- naphthalene; 2,3-dimethylthio-1,4-di(4-t-butylbenzoyloxy)- naphthalene; 2,3-dimethylthio-1,4-diphenylacetyloxy)naphthalene; 2,3-diphenylthio-1,4-diacetyloxynaphthalene; 6-chloro-2, 3-diphenylthio-l,4-dibenzoyloxynaphthalene; and 6-chloro-2,3-diphenylthio-1,4-diphenylacetyloxy- naphthalene. 6,7-dimethyl-2,3-dimethylthio-1,4-diacetyloxynaphthalene; EXAMPLE 3 Biological Data As indicative of anti-psoriatic activity, the following test was carried out. Inhibition of Arachidonic Acid Induced Mouse Ear Edema MATERIALS AND METHODS Male or female Swiss Webster mice weighing 18-27 g were randomly assigned to treatment groups of 8 or 10 animals, caged together, and given food and water ad libitum. The test materials were prepared as solutions or suspensions in reagent grade acetone at a dose level of 100 mg/ml and arachidonic acid was prepared as a solution in acetone also at 100 mg/ml. The test materials were applied to the right ears of mice by means of an automatic microliter pipet so that 10 iii of solution was applied to each of the inner and outer surfaces. Each ear therefore received a total of 20 p1 of solution containing 2 mg of test material. One hour after application of the test material, the arachidonic acid solution was applied in the same manner. One hour after the arachidonic acid application the animals were sacrificed by cervical dislocation and the right ears were removed. An 8 mm disc was punched from each ear with a biopsy punch, and the discs were weighed to the nearest 0.1 mg. For the purpose of determining the anti-inflammatory effect of test materials a negative control group receiving two applications of acetone only, and a positive control group receiving acetone alone followed by arachidonic acid were run in each experiment. The percent inhibition resulting froe treatment with the test material was calculated as follows: % Inhib.= Plug wt. (Pos. Control) - Plug wt. (Treated) Plug wt. (Pos. Control) - Plug wt. gNeg. control) X 100 RESULTS Table Inhibition of Arachidonic Acid Induced Mouse Ear Inflammation OC(O)W (R )m# bc(o) %Edema R1 & R2 R3 M W Inhibition phenoxy 6-Cl 1 CH3 5 CH3O 6-Cl 1 phenyl 18 CH30 6,7-diCH3 2 CH2CH3 46 CH30 6,7-diCH3 2 CH2CH2CH3 14 CH3 6,7-diCH3 2 CH(CH3)2 21 CH30 6,7-diCH3 2 CH3 19 CH30 6,7-diCH3 2 C(CH3)3 6

Claims: CLAIMS 1. A composition in a form suitable for topical administration for treating the condition of psoriasis which composition comprises a pharmaceutically acceptable, non-toxic carrier and a psoriasis relieving amount of a compound of the formula EMI45.1 wherein: R1 and R2 are the same and are lower alkoxy of one to six carbon atoms, lower alkylthio of one to six carbon atoms, phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; R is lower alkyl of one to six carbon atoms, lower alkoxy of one to six carbon atoms, or halo and m is 0, 1 or 2 or R3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O)nR wherein R is lower alkyl of one to six carbon atoms; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or heterocyclic aryl of three to nine ring atoms containing one r two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, phenyl or benzyl optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; with the proviso that when R1 and R2 are optionally substituted phenoxy or optionally substituted phenylthio, m is O, 1, or 2; with the proviso that when W is an alkyl group of two to seven carbon atoms and R1 and R2 are alkoxy of two to six carbon atoms, m is O or 2. 2. The composition of Claim 1 wherein m is 2. 3. The composition according to Claim 1 wherein the compound is EMI46.1 wherein R1, R2, R3, and W are as defined in Claim 1 and m is O or 1. 4. The composition of Claim 3 wherein W is alkyl of one to seven carbon atoms. 5. The composition according to Claim 4 wherein R1 and R2 are the same and are phenoxy or phenylthio optionally substituted by one or more lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo. 6. The composition of claim 3 wherein W is phenyl or benzyl optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo. 7. The composition of Claim 6 wherein R1 and R2 are the same and are lower alkoxy of one to six carbon atoms or lower alkylthio of one to six carbon atoms. 8. The composition of Claim 6 wherein R1 and R2 are the same and are phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo. 9. A compound of the formula EMI47.1 wherein: R1 and R2 are the same and are lower alkoxy of one to six carbon atoms, lower alkylthio of one to six carbon atoms, phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; R3 is lower alkyl of one to six carbon atoms, lower alkoxy of one to six carbon atoms, or halo and m is 0, 1 or 2 or optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O)nR wherein R is lower alkyl of one to six carbon atoms; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, phenyl or benzyl optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; with the proviso that m is not 0 or 1 when R1 and R2 are methoxy and W is methyl. 10. The compound of Claim 9 wherein m is 2. 11. A compound of Claim 9 of the formula EMI48.1 wherein R1 , R2 R3 and W are as defined in Claim 9 and m is O or 1. 12. The compound according to Claim 11 wherein R3 is selected from the group consisting of halo, cyano, and alkoxy of one to four carbon atoms. 13. The compound according to Claim 12 wherein R3 is selected from the group consisting of fluoro, chloro and bromo and m is 1. 14. The compound according to Claim 11 wherein R3 is cyano. 15. The compound of Claim 13 wherein W is alkyl of one to seven carbon atoms. 16. A compound of Claim 15 wherein R1 and R2 are the same and are phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo. 17. A compound of Claim 16 which is 6-chloro-2,3diphenoxy-1,4-diacetyloxynaphthalene; 6-chloro-2,3-diphenoxy-1,4-di-n-propanoyloxynaphthalene; or 6-chloro-2, 3-diphenoxy-l , 4-di-n-butanoyloxynaphthtalene. 18. The compound of Claim 13 wherein W is phenyl or benzyl optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo. 19. The compound of Claim 18 wherein R1 and R2 are the same and are lower alkoxy of one to six carbon atoms or lower alkylthio of one to six carbon atoms. 20. The compound of Claim 19 which is 6-chloro 2,3-dimethoxy-1,4-dibenzoyloxynaphthalene. 21. The compound of Claim 18 wherein R1 and R2 are the same and are phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo. 22. The compound of Claim 21 which is 6-chloro 2,3-diphenoxy-1,4-dibenzoyloxynaphthalene. 23. A process for the preparation of compounds of formula (I) EMI50.1 wherein: R1 and R2 are the same and are lower alkoxy of one to six carbon atoms, lower alkylthio of one to six carbon atoms, phenoxy or phenylthio optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; R3 is lower alkyl of one to six carbon atoms, lower alkoxy of one to six carbon atoms, or halo and m is 0, 1 or 2 or R3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, or S(O)nR wherein R is lower alkyl of one to six carbon atoms; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, phenyl or benzyl optionally substituted by one or two lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; with the proviso that n is not 0 or 1 when R1 and R2 are methoxy and W is methyl. which comprises reacting a compound of the formula EMI51.1 wherein: R1, R2, R3 and m are as defined above with an acid anhydride. optionally followed by (a) converting the free compound of formula (I) 3 wherein R3 is s(0) n R wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen an9 sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano, to a pharmaceutically acceptable acid addition salt; or (b) converting a pharmaceutically acceptable acid addition salt of a compound of formula (I) wherein R3 is S(û)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano, to the free compound of formula (I) wherein R3 is S(O)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano; or (c) converting a pharmaceutically acceptable acid addition salt of a compound of formula (I) wherein R3 is S(û)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halo and cyano, to another pharmaceutically acceptable acid salt of a compound of formula (I) wherein R is S(O)nR wherein R is heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur wherein the heterocyclic aryl is optionally substituted by one or more substituents selected Rrom the group consisting of lower alkyl, lower alkoxy, halo and cyano.

Inventors: JONES, GORDON H., VENUTI, MICHAEL C., YOUNG, JOHN M.
Applicants: SYNTEX (U.S.A.) INC.
Application year: 1984
Main classification: A61K31
IPC codes: C07D213, A61K31, C07C317, C07C205, C07D521, A61P17, C07C323, C07C69, A61P29, C07C313, C07C213, C07C50, C07C255, C07C219, C07C46, C07C67, C07C253