Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them

Abstract: Pharmaceutical compositions contain a compound for the Formula I: or a pharmaceutically acceptable salt thereof. Certain com­ pounds of Formula I are novel. Compounds of Formula I are useful in treating allergic conditions, asthma, cardrovascular disorders, inflammation and pain and are useful as cytop­ rotective agents. In Formula I, X is O, S, SO or SO₂; R₁ is H; C₁₋₆ alkyl; C₁₋₆ acyl; C₁₋₆ aminoacyl; (C₁₋₆ acyloxy)-(C₁₋₆ alkyl); (C₁₋₆ alkoxy)-(C₁₋₆ alkyl); benzoyl; substituted benzoyl in which the substitution in the phenyl ring (herein called "substituted as herein defined") is halogen, C₁₋₃ alkyl, C₋₁₃ alkoxy, CN, CF₃, COOR₆, OH, CH₂COOR₆ or (CH₂) n NR₈R₉ where n is 0, 1 or 2; carbamoyl; CONHR₇; COOR₇; p-toluenesulfonyl; methane sulfonyl; or an acyl group such that R₁-OH is an essential amino acid; each of R₂, R₃, R₄ and R₅, independently of the others, is hydrogen; C₁₋₆ alkyl; C₂₋₆ alkenyl; -(CHR₆) p COOR₆, p being 0 or an integer from 1 to 4; or -(CH₂) m M where m is 0 or an integer from 1 to 6 and M is (a) OR₁₅; (b) halogen; (c) CF₃; (d) SR₁₅; (e) phenyl or substituted phenyl as herein defined; (f) COOR₆; (g) CO-R₁₄; (h) tetrazolyl; (i) -NH-CO-R₇; (j) -NR₈R₉; (k) -NHSO₂R₁₀ where R₁₀ is OH, C₁₋₆ alkyl, C₁₋₆ alkoxy, or phenyl; (l) -COCH₂OH; (m) -SOR₁₁ where R₁₁ is C₁₋₆ alkyl; phenyl; substituted phenyl as herein defined; (CH₂) m COOR₆;CN; formyl or C₁₋₄ perfluoroalkyl; (n) -CONR₈R₉; (o) -SO₂NR₈R₉; (p) -SO₂R₁₃ where R₁₃ is a hydrogen atom or a radical of the type defined for R₁₁; (q) NO₂; (r) O-CO-R₁₄; (s) O-CO-NR₈R₉; (t) -CN; or (u) -OPO(OR₆)₂; each R₆, independently of any other, is H, phenyl or C₁₋₆ alkyl; each R₇, independently of any other, is C₁₋₆ alkyl, benzyl, phenyl or (C₁₋₆ acyloxy)-(C₁₋₆ alkyl); each R₈ and each R₉, independently of any other, is phenyl, substituted phenyl as herein defined, or C₁₋₄ alkyl, or -NR₈R₉ represents a heterocycloalkyl radical of 5 to 8 ring atoms; each R₁₄, independently of any other, is H, (CH₂) p COOR₆, C₁₋₆ alkyl, C₁₋₆ alkoxy, (C₁₋₆ acyloxy)-(C₁₋₆ alkoxy), phenyl, substituted phenyl as herein defined, or C₁₋₆ aminoalkyl, or R₁₄ is such that R₁₄CO₂H is an essential amino acid; R₁₅ is H, (C₁₋₆ alkoxy)-(C₁₋₆ alkyl), (C₁₋₆ acyloxy)-(C₁₋₆ alkyl), C₁₋₆ alkyl, benzyl, -(CH₂) m COOR₆, CN, formyl, C₁₋₄ perfluoroalkyl, CH₂-R₁₂ where R₁₂ is C₁₋₆ alkyldimethylami­ no or phenyl, phenyl, or substituted phenyl as herein defined; the broken lines in ring A represent optional double bonds; R₂, R₃, R₄ and R₅ may be positioned anywhere in the structure.

Description: BENZO lal PHENOTHIAZINES AND HYDRO-DERIVATIVES AND PHARMACEUTiCAL COMPOSITIONS CONTAINING THEM Benzola]phenothiazine and hydro-derivatives and analogs thereof are useful as inhibitors of the biosynthesis of mammalian leukotrienes. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation and pain. These compounds may be used to treat or prevent mammalian (especially human) disease states such as erosive gastritis; erosive esophagitis; inflammatory bowel disease; ethanol-induced hemorrhagic erosions; hepatic ischemia; noxious agent induced damage or necrosis of hepatic, pancreatic, renal, or myocardial tissue; liver parenchymal damage caused by hepatoxic agents such as CC14 and D-galactosamine; ischemic renal failure; disease induced hepatic damage; bile salt induced pancreatic or gastric damage; trauma- or stressinduced cell damage; and glycerol-induced renal failure. The leukotrienes are a novel group of biologically active substances derived from arachidonic acid through the action of the 5-lipoxyqenase enzyme system. There are two groups of leukotrienes derived from a common unstable precursor Leukotriene A4. The first of these are the peptido-lipid leukotrienes, the most important being Leukotrienes C4 and D4. These compounds collectively account for the biologically active material known as the slow reacting substance of anaphylaxis. The leukotrienes are potent smooth muscle contracting agents, particularly on respiratory smooth muscle but also on other tissues (e.g., gall bladder). In addition, they promote mucous production, modulate vascular permeability changes and are potent inflammatory agents in human skin. The most important compound in the second group of leukotrienes is Leukotriene B4, a dihydroxy fatty acid. This compound is a potent chemotactic agent for neutrophils and eosinophils. It also effects other cell types such as lymphocytes and for example may modulate the action of T-suppressor cells and natural killer cells. When injected in vivo, in addition to promoting the accumulation of leukocytes, Leukotriene B4 is also a potent hyperalgesic agent and can modulate vascular permeability changes through a neutrophil dependent mechanism. See: D. M. Bailey and F. B. Casey, Ann. Rpts. Med. Chem. 17, 203 (1982). As indicated above, the leukotrienes have been implicated in numerous disease states. Inhibition of leukotriene biosynthesis and/or antagonism of leukotriene action, will therefore provide a therapeutic benefit to patients suffering from leukotriene mediated disease states. These disease states include, but are not limited to; asthma; allergic conditions such as allergic rhinitis; skin diseases including psoriasis and atopic dermatitis; inflammation; gouty arthritis; gall bladder spasms; and cardiovascular disorders such as angina. Certain benzotalphenothiazine derivatives of the general Formula A are known compounds: EMI3.1 Some of these compounds have been used (inter alia) as antioxidants, dyes, whitening agents, photosensitizers and polymerization retardants. See for example; T. G. Jackson et al., J. Org. Chem. 32 1190-1194 (1967), J. A. Van Allen et al., J. Organ. Chem. 34 1691-1694 (1969), T. G. Jackson et al. J. Med. Chem. 11 622-623 (1968), N. L. Agarwal et al., Acta Chim. Acad. Sci. Hung. 92 89-97 (1977), R. L. Mital et al., J. Inst. Chem. (India) 49 286-287 (1977), J. P. Tiwari et al., Anorg. Chem., Org. Chem. 33B 214-215 (1978), J. P. Tiwari et al., Indian J. Chem. Sect. B 17B 408-409 (1979), Y. Ueno et al., J. Heterocycl. Chem. 19 167-169 (1982), S. Kikkawa et al., Chemical Abstracts 76 139757q (1972) and French Patent No. 1,541,977 (1968). It has been discovered that compounds of the Formula A type and analogs thereof are effective inhibitors of mammalian leukotriene biosynthesis and are thus useful in the treatment of conditions such as asthma, allergies, inflammation, and the like in mammals, especially in humans. The present invention relates to pharmaceutical compositions containing a compound of the Formula I: EMI4.1 wherein X is O, S, SO or SO2; pharmaceutically acceptable salts thereof; a method of treatment using compounds of Formula I; and certain novel compounds of Formula I. In one of its embodiments, the present invention relates to a pharmaceutical composition containing a compound of the Formula I and a pharmaceutically acceptable carrier: EMI5.1 wherein: X is 0, S, SO or SO2; R1 is H; C1 to C6 alkyl; C1 to C6 acyl; C1 to C6 aminoacyl; C1 to C6 acyloxy-C1 to C6 alkyl (e.g. -CH(CH3)OCOC(CH3)3); C1 to C6 alkoxy-C1 to C6 alkyl (e.g. -CH(CH3)0C2H5); EMI5.2 phenyl wherein substituted phenyl is as defined below in the definition of R15; carbamoyl; EMI5.3 EMI5.4 SO2-C6H4-p-CH3; SO2CH3; or R1 is an acyl group such that R1-OH is an essential amino acid; R2, R3, R4 and R5 are independently selected from: (1) hydrogen; (2) alkyl having 1 to 6 carbon atoms; (3) alkenyl having 2 to 6 carbon atoms; (4) -(CH2)nM wherein n is 0 to 6 and M is a) OR15; b) halogen; c) CF3; d) SR15 wherein R15 is H; C1 to C6 alkoxy-C1 to C6 alkyl; C1 to C6 acyloxy-C1 to C6 alkyl; C1 to C6 alkyl; benzyl; (CH2)mCOOR6 wherein m is 0 to 6; CN; formyl; C1 to C4 perfluoroalkyl; CH2-R12 wherein R12 is C1 to C5 alkyldimethylamino or phenyl; phenyl; substituted phenyl wherein the substituents are C1 to C3 alkyl, halogen, CN, CF3, COOR6, CH2COOR6, (CH3)nNR8R9 wherein n is 0 to 2, C1 to C3 alkoxy or OH; (e) phenyl or substituted phenyl wherein substituted phenyl is as defined in the definition of R15; (f) COOR6; EMI6.1 (h) tetrazole; EMI6.2 (j) -NR8R9; (k) -NHSO2R10 wherein R10 is OH, C1 to C6 alkyl, C1-C6-alkoxy, or phenyl; EMI6.3 (m) -SOR11 wherein R11 is C1 to C6 alkyl; phenyl; substituted phenyl wherein substituted phenyl is as defined in the definition of R15; (CH2)mCOOR6 wherein m is 1 to 6; CN; formyl or perfluoro-C to C4 alkyl; (n) CONR8R9; (0) -S02NR8Rg; (p) -S02R13 wherein R13 is OH; C1 to C6 alkyl; H; phenyl; substituted phenyl wherein substituted phenyl is as defined in the definition of R15; (CH2)mCOOR6 wherein m is 1 to 6; CN; formyl or perfluoro-C1 to C4 alkyl (q) NO2; EMI7.1 (t) -CN; or (u) -OPO(OR6)2; and (5) (CHR6)nCOOR6 wherein n is 0 to 4; each R6 is independently H, phenyl or C1 to C6 alkyl; each R7 is C1 to C6 alkyl, benzyl, phenyl or C1 to C6 acyloxy-C1 to C6 alkyl; each R8 and each Rg is in dependently H, phenyl or substituted phenyl, wherein substituted phenyl is as defined in the definition of R15, or C1 to C4 alkyl, or an R8 and Rg may be joined through the N to form a heterocycloalkyl of 5 to 8 ring atoms; ; each R14 is independently H, OH, (CH2)nCOOR6 wherein n is 0 to 4, C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 acyloxy-C1 to C6alkoxy, phenyl or substituted phenyl wherein substituted phenyl is as defined in the definition of R15, C1 to C6 aminoalkyl, or R14 is such that R14C02H is an essential amino acid; and the broken lines in ring A represent optional double bonds. R2, R3, R4 and R5 may be positioned anywhere in the structure. Pharmaceutically acceptable salts of the compounds described herein are included within the scope of the present invention. Such salts may be prepared from pharmaceutically acceptable non-toxic bases including inorganic bases and organic bases when the compound is acidic. Salts derived from inorganic bases include sodium, potassium, lithium, ammonium, calcium, magnesium, ferrous, zinc, copper, maganous, aluminum, ferric, maganic salts and the like. Particularly preferred are the potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and teriary amines, substituted amines including naturally occuring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, tri-methylamine, diethanolamine, diethylamine, triethylamine, tripropylamine ethanolamine, 2-dimethylaminoethanol, 2-diethylaminoethanol, tomethamine, lysine, arginine, histidine, betaine, ethylenediamine, glucosamine, methylglucamine, theobromine, purines, piperazine, N,N'-dibenzylethylenediamine, piperidine, N-ethyl-piperidine, morpholine, N-ethylmorpholine, polyamine resins and the like. When the compound is basic, salts may be prepared from pharmaceutically acceptable non-toxic acids, including inorganic and organic acids. Such acids include hydrochloric, hydrobromic, sulfuric, nitric, isethionic, methanesulfonic, ethanesulfonic, benzenesulfonic, p-tolueuesulfonic, acetic, benzoic, comphorsulfonic, citric, fumaric, gluconic, glutamic, lactic, malic, maleic, mandelic, mucic, pamoic, pantothenic, phosphoric, succinic tartaric acid and the like. Particularly preferred are hydrochloric, hydrobromic, citric, maleic, phosphoric, sulfuric and tartaric acids. For helpful discussion of pharmaceutical salts see S.M. Berge et al., Journal of Pharmaceutical Sciences, 66, 1-19 (1977) , the disclosure of which is hereby incorporated herein by reference. As used herein, the term alkyl, unless otherwise indicated, includes straight chain, branched chain and cycloalkyl groups of the number of carbon atoms shown. The term halogen, as used herein, unless otherwise indicated, includes C1, Br, I and F. The term essential amino acid, as used herein (for example, see the definitions following Formula I and Formula II), includes the following amino acids: lysine, tryptophan, histidine, phenylalanine, leucine, isoleucine, threonine, methionine, valine, arginine, alanine, proline, glycine, serine, cysteine, tyrosine, asparagine, glutamine, aspartic acid and glutamic acid. A preferred composition is comprised of compounds having the Formula II; EMI9.1 wherein: X is O, S, SO or SO2; R1 is hydrogen, C1 to C4 alkyl, C1 to C4 lower acyl, C1 to C6 amino-acyl, C1 to C6 acyloxy-Cl to C6 alkyl (e.g. CH(CH3)OCOC(CH3)3), or -COORd wherein Rd is C1 to C4 alkyl or C1 to C4 acyloxy-C1 to C4 alkyl (e.g. CH(CH3)OCOCH3); R2, R3, R4 and R5 are each independently selected from hydrogen, halogen (F, C1, Br, I), CH3, CF3, COCH3, Rb, SR6, CH2OH, ORb, COORb and CH2COORb, wherein each Rb is independently selected from H and C1 to C4 alkyl; and Ra is H; C1 to C5 alkyl; C1 to C5 acyl; C1 to C6 alkoxy-C1 to C6 alkyl; C1 to C6 acyloxy-C1 to C6 alkyl; C1 to C4 aminoacyl; carbamoyl; EMI10.1 phenyl wherein substituted phenyl is as defined in the definition of R15 of Formula I; EMI10.2 wherein Rc is C1 to C4 alkyl; EMI10.3 wherein Rd is as defined above; or is a structure such that -OR a is an ester of an essential amino acid. The substituents R2, R3, R4, R5 and OR a may be located anywhere in the molecule. A more preferred composition is comprised of compounds of Formula III: EMI11.1 wherein: X is O or S; and R1, R2, R3, R4, R5 and Ra are as defined for Formula II. Examples of the Formula - compounds useful in the compositions of the presen- invention are tabulated below. In Table I, the number preceding the R2-R5 definitions signifies that group's position on the ring system. A still more preferred composition is comprised of compounds of Formula III wherein X is S and the remaining substitueuts are as defined for Formula III, with the proviso that at least one of R1 or Ra is not hydrogen. TABLE I COMPOUNDS OF FORMULA I EMI12.1 Compound X Ring A R1 R2 R3 R4-R5 1. S aromatic H 5-OH H H H 2.1 S aromatic H 5-OCOCH3 6-Cl H H 3. S aromatic H H H H H 4. S aromatic H 5-OH 6-C1 H H 5. S aromatic H 5-OH 6-Cl 9-Cl H 6. S aromatic H 5-OH 6-C1 9-OCH3 H 7. S aromatic H 5-OCOCH3 6-C1 9-CH3 H 8. 0 aromatic H 5-OH H H H 9. 1,2 O aromatic H 5-OCOCH3 H H H 10. 50 aromatic H 5-OH H H H a The symbol 1 next to the number of a compound indicates which compounds are preferred and the symbol 2 next to the number of a compound indicates which campounds are also more preferred. TABLE I (CONT'D) Compounda X Ring A R1 R2 R3 R4 R5 11. 1.2 SO2 aromatic H 5-OH H H H 12. SO aromatic H H H H H 13. 5 2 aromatic H H H H H 14. SO aromatic COCH3 H H H H 15. S aromatic H 1-CO2H H H H 16. S aromatic CH3 2-Et H H H 17. 5 aromatic COCH3 2-COCH3 H H H 18. S aromatic H 2-COCH3 H H H 19. S aromatic H H H H 10-phenyl 20. S aromatic H H H 8-CH3 11-CH3 21. S aromatic H H H H 22. S aromatic H 5-OH 6-NHCOCH3 9-F H 23. 5 aromatic H 5-OH 6-NH-phenyl 9-C1 H 24. SO aromatic H 5-OAc 6-C1 H 10-CF3 TABLE I (CONT'D) X Ring A R1 R2 R3 R4 R5 25. SO aromatic H 5-OCH2Ph 6-C1 H 10-CF3 26. S aromatic H 5-OH 6-C1 9-CH3 11-CH3 27. S aromatic H 5-OCH3 6-C1 9-OCH3 H 28. SO2 1,4-dihydro H 5-OH H H H 29. SO2 aromatic COCH3 4-CH3 H 9-SCH3 H 30. 0 aromatic H H H 9-SO2CF3 H 31 0 aromatic H H H 11-CH3 H 32. S aromatic COCH3 5-OCOMe H H H 33. S aromatic CH2OAc 5-OH H H H 34. S aromatic CH2OAc 5-OCOMe H H H 35. S aromatic Me 5-OH H H H 36. 1,2 5 aromatic H 5-OCOCH3 H H H 37. S aromatic CH3 5-OCH3 H H H 38. S aromatic CH3 5-OCOCH3 H H H TABLE I (CONT'D) Compounda X Ring A R1 R2 R3 R4 R5 39. S aromatic COCH3 5-OH H H H 40. S atomatic COCH3 5-OCH3 H H H 41. 1 S atomatic H 5-OCOCH2NH2 H H H 42. 1 S 1,4-dihydro H S-OH H H H 43. 1 S atomatic H 5-OCOCH(CH3)2 H H H 44. 1 S atomatic H 5-OCOC(CH3)3 H H H 45. 1 S atomatic H 5-OCOC6H5 H H H 46. 1 S atomatic H 5-OH 6-CH3 H H 17.1 S atomatic H 5-OCOCH3 6-CH3 H H 48. 5 aromatic H 5-OH 1-OH 6-CH3 H 49. S atomatic H 5-OCOCH3 1-OH 6-CH3 H 50. 5 aromatic H 5-CH 1-OCH3 6-CH3 H 51. S atomatic H 5-OCOCH3 1-OCH3 6-CH3 H 52. S atomatic H 5-OCOC(CH3)3 1-OCH3 6-CH3 H 53. S 1,4-dihydro H 5-OCOCH3 H H H TABLE I (CONT'D) Compound X Ring A R1 R2 R3-R4 R, 54. SO2 0,4-dihydro H 5-OCOCH3 H H H 55. SO aranatic H 5-OCOCH3 H H H 56. 1,2 SO2 aromatic H 5-OCOCH3 H H H 57. S atomatic H 5-OCH2OCH3 H H H 58. 5 aromatic H 5-OCH3 H H H 59. S atomatic H 5-OCOC6H4-p-OMe H H H 60. S aromatic H 5-OCOC6H4-p-Cl H H H 61. 5 aromatic H 5-OCOC6H4-p-NH2 H H H 62. S aromatic H 5-OCOC6H4-p- H H H CO2H 63. 5 aromatic H 5-OCOC6H4-O- H H H CF3 64. S atomatic H 5-OCOC6H4-m-CH H H H 65. S atomatic H 5-OCO(CH2)2- H H H 002H 66. S aromatic H 5-OCO(CH2)4- H H H CO2H TABLE I (CONT'D) EMI17.1 <tb> Ring <SEP> wunda¯X <SEP> ring <SEP> A <SEP> R1 <SEP> R2 <SEP> R <SEP> R <SEP> 4 <SEP> R5¯ <SEP> R <tb> <SEP> -5' <tb> 67. <SEP> S <SEP> aromatic <SEP> H <SEP> 54)COCX(NH2)CH3 <SEP> H <SEP> H <SEP> H <tb> 68. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OCOCH <SEP> (NH,)- <SEP> H <SEP> H <SEP> H <tb> <SEP> CH2C6H5 <tb> 69 <SEP> 1,2 <SEP> 5 <SEP> aromatic <SEP> CO2CHCH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> <SEP> Qac <tb> 70 <SEP> 1,2 <SEP> 5 <SEP> aromatic <SEP> 002CHCH3 <SEP> 5-OAc <SEP> H <SEP> H <SEP> H <tb> a <tb> <SEP> CAc <tb> 71. <SEP> S <SEP> aromatic <SEP> CO2CHCH3 <SEP> 5-OCO2CHCH3 <SEP> H <SEP> H <SEP> H <tb> <SEP> OAc <SEP> OAc <tb> 72. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OCO <SEP> CHCH <SEP> H <SEP> H <SEP> H <tb> <SEP> c <tb> 73. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OPO <SEP> (OEt) <SEP> H <SEP> H <SEP> H <tb> <SEP> 2 <tb> 74. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9OMe <SEP> H <SEP> H <tb> 75. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-GAc <SEP> 9Some <SEP> H <SEP> H <tb> 76. <SEP> S <SEP> aromatic <SEP> H <SEP> 50H <SEP> 9fly <SEP> H <SEP> H <tb> 77. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OAc <SEP> 9-Me <SEP> H <SEP> H <tb> 78. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9-F <SEP> H <SEP> H <tb> TABLE I (CONT'D) EMI18.1 <tb> Cmounda <SEP> X <SEP> Ring <SEP> A <SEP> R1 <SEP> 2 <SEP> R3 <tb> 79. <SEP> S <SEP> aromatic <SEP> H <SEP> S4c <SEP> 94 <SEP> H <SEP> H <tb> 80. <SEP> S <SEP> aromatic <SEP> H <SEP> 5XH <SEP> 6ZAc <SEP> H <SEP> H <tb> 81. <SEP> 5 <SEP> aromatic <SEP> H <SEP> 54c <SEP> 641Ac <SEP> H <SEP> H <tb> 82. <SEP> S <SEP> aromatic <SEP> Ac <SEP> 54H <SEP> 6-OH <SEP> H <SEP> H <tb> 83. <SEP> S <SEP> aromatic <SEP> Ac <SEP> S4c <SEP> 6ZAc <SEP> H <SEP> H <tb> 84. <SEP> 502 <SEP> aromatic <SEP> H <SEP> SOH <SEP> 5XH <SEP> H <SEP> H <tb> <SEP> 12 <tb> 85. <SEP> 1,2 <SEP> 0 <SEP> aromatic <SEP> CO2CHCH3 <SEP> 5 <SEP> OH <SEP> H <SEP> H <SEP> H <tb> <SEP> Me <tb> 86. <SEP> SO2 <SEP> aromatic <SEP> COZCHCH3 <SEP> 54)H <SEP> H <SEP> H <SEP> H <tb> <SEP> 2 <SEP> 3 <tb> The compounds of the Formula I have unexpected activity as inhibitors of the mammalian biosynthesis of both leukotriene B4, as well as leukotrienes C4, D4, E4 and F4, the active elements of slow reacting substance of anaphylaxis (SRS-A). This inhibition of the biosynthesis of leukotrienes indicates that the compositions would be useful to treat, prevent or ameliorate, in mammals and especially in humans 1) pulmonary conditions including diseases such as asthma, 2) allergies and allergic reactions such as allergic rhinitis, contact dermatitis, allergic conjunctivitis and the like, 3) inflammation such as arthritis, 4) pain, 5) skin conditions such as psoriasis and the like and 5) cardiovascular conditions such as angina and the like. Representative compounds of Formula I have been tested using one or more of the following assays to determine their mammalian leukotriene biosynthesis inhibiting activity or their activity in assays relevant to the above disease conditions. Rat Peritoneal Polymorphonuclear (PMN) Leukocyte Assay Rats under ether anesthesia are injected (i.p.) with 8 ml of a suspension of sodium cascinate (6 grams in ca. 50 ml water). After 15-24 hr. the rats are sacrificed (CO2) and the cells from the peritoneal cavity are recovered by lavage with 20 ml of buffer (Eagles MEM containing 30 mM HEPES adjusted to pH 7.4 with NaOH). The cells are pelleted (350 x g, 5 min.), resuspended in buffer with vigorous shaking, filtered through lens paper, recentrifuged and finally suspended in buffer at a concentration of 10 cells/ml. A 500 p1 aliquot of PMN suspension and test compound are preincubated for 2 minutes at 370C, followed by the addition of 10 vM A-23187. The suspension is stirred for an additional 4 minutes then bioassayed for LTB4 content by adding an aliquot to a second 500 pl portion of the PMN at 370C. The LTB4 produced in the first incubation causes aggregation of the second PMN, which is measured as a change in light transmission. The size of the assay aliquot is chosen to give a submaximal transmission change (usually -70%) for the untreated control. The percentage inhibition of LTB4 formation is calculated from the ration of transmission change in the sample to the transmission change in the compound-free control, Asthmatic Rat Assay Rats were obtained from an inbred line of asthmatic rats. Both female and ale rats from 200 to 300 g were used. Egg albumin (EA), grade V, crystallized and lyophilized, was obtained from Sigma Chemical Co., St. Louis. Bordetella pertussis vaccine, containing 30 x 109 killed bacteria per ml was obtained from the Institut Armand-Frappier, Laval des Rapides, Quebec. Aluminum hydroxide was obtained from the Regis Chemical Company, Chicago. The challenge and subsequent respiratory recordings were carried out in a clear plastic box with internal dimensions 10 x 6 x 4 inches. The top of the box was removable; in use, it was held firmly in place by four clamps and an airtight seal was maintained by a soft rubber gasket. Through the center of each end of the chamber a Devilbiss nebulizer (No. 40) was inserted via an airtight seal and each end of the box also had an outlet. A Fleisch No. 0000 pneumotachograph was inserted into one end of the box and coupled to a Grass volumetric pressure transducer (PTS-A) which was then connected to a Beckman Type R Dynograph through appropriate couplers. While aerosolizing the antigen, the outlets were open and the pneumotachograph was isolated from the chamber. The outlets were closed and the pneumotachograph and the chamber were connected during the recording or the respiratory patterns. For challenge, 2 ml of a 3% solution of antigen in saline was placed into each nebulizer and the aerosol was generated with air from a small Potter diaphragm pump operating at 10 psi and a flow of 8 liters/minute. Rats were sensitized by injecting (s.c.) 1 ml of a suspension containing 1 mg EA and 200 mg aluminum hydroxide in saline. Simultaneously, they received an injection (i.p.) of 0.5 ml of B. pertussis vaccine. They were used between days 14 and 18 postsensitization. In order to eliminate the serotonin component of the response, rats were pretreated intravenously 5 minutes prior to aerosol challenge with 30 gm kg 1 methylsergide. Rats were then exposed to an aerosol of 3% EA in saline for exactly 1 minute, then their respiratory profiles were recorded for a further 25-30 minutes. The duration of continuous dyspnoea was measured from the respiratory recordings. Compounds were generally administered either intraperitoneally 1 hour prior to challenge or orally 1-1/2 hours prior to challenge. They were either dissolved in dimethylsulfoxide or suspended in 0.1% methocel and 0.5% Tween 80. The volume injected has 2 ml kg 1 (intraperitoneally) or 10 ml kg 1 (orally). Prior to oral treatment rats were starved overnight. Their activity was determined in terms of their ability to decrease the duration of symptoms of dyspnoea in comparison with a group of vehicletreated controls. Usually, a compound was evaluated at a series of doses and an ED50 was determined. This was defined as the dose (mg/kg) which would inhibit the duration of symptoms by 50%. PAF-Induced Hyperalgesia Assay Female Sprague-Dawley rats, 35-40 g were fasted overnight. Platelet activating factor, PAF, (L-lecithin B-acetyl O-alkyl) 1 veg/0.1 ml was given by subplantar injection in the rat paw. The compounds to be evaluated were homogenized in Aqueous Vehicle (0.9% benzyl alcohol, 0.5% Tween 80 and 0.4% methylcellulose) and administered orally in a volume of 0.1 ml, 30 minutes prior to PAF. Animals were tested 1, 2, 3 and 4 hours after PAF administration. The vocalization threshold, defined as the pressure (mmHg) needed to evoke a squeak response, was recorded for both the injected and contralateral paw. No animal was subjected to pressure greater than 60 mmHg. Hyperalgesia is defined as a decrease in vocalization threshold as compared to a normal paw. Percent inhibition of hyperalgesia was calculated as the proportion of animals with vocalization thresholds greater than 200% of controls. Following in Table II is data obtained using these various assays with representative compounds of Formula I. TABLE II ASSAY RESULTS EMI24.1 PAF Ring A R1 Ra X PMN Asth. Rat Induced IC50 % Inhibition Hyperalgesia (mg/ml) and Dose % Inhibition (mg/kg) and Dose (p.o.) (mg/kg) (p.o.) aromatic H Ac S 0.025-0.05 @@50: ED50: 4 mg/kg 0.145 mg/kg aromatic Me be S 5 - G- (3) 40% (1) aromatic Me Ac 5 0.05 - 30-60% (1) aromatic Ac H S 1-5 aromatic Ac Me S 5 aromatic H H S 0.02-0.1 54% (1.5) TABLE II (CONT'D) EMI25.1 <tb> <SEP> PAF <tb> Ring <SEP> A <SEP> R1 <SEP> R <SEP> X <SEP> PHN <SEP> Asth. <SEP> Rat <SEP> Induced <tb> <SEP> a <tb> <SEP> IC50 <SEP> S <SEP> Inhibition <SEP> Hyperalgesia <tb> <SEP> Eng/ml) <SEP> and <SEP> Dose <SEP> % <SEP> Inhibition <tb> <SEP> Eng/kg) <SEP> and <SEP> Dose <tb> <SEP> (p.o.) <SEP> (mg/kg) <tb> <SEP> (D.o.) <tb> aromatic <SEP> H <SEP> COCH2NH2 <SEP> S <SEP> 0.04-0.2 <SEP> 44S <SEP> (3) <tb> <SEP> (HC1 <SEP> 21S <SEP> (1.5) <tb> 1,4-dihydro <SEP> H <SEP> H <SEP> 5 <SEP> 0.04 <SEP> <tb> aromatic <SEP> H <SEP> CH,OCH, <SEP> S <SEP> 1-5 <SEP> <tb> aromatic <SEP> H <SEP> COPh <SEP> S <SEP> 0.5 <SEP> 18S <SEP> (5) <tb> aromatic <SEP> H <SEP> COC(CH3)3 <SEP> S <SEP> 0.1-1 <SEP> 54S <SEP> (5) <tb> <SEP> 33 <tb> aromatic <SEP> H <SEP> OR <SEP> =H <SEP> S <SEP> 0.2-1 <SEP> <tb> <SEP> a <tb> aromatic <SEP> H <SEP> Me <SEP> S <SEP> 0.1 <SEP> <tb> aromatic <SEP> H <SEP> PO(OEt) <SEP> t)2 <SEP> S <SEP> 0.2-1 <SEP> <tb> <SEP> 2 <tb> aromatic <SEP> Ac <SEP> Ac <SEP> 5 <SEP> - <SEP> 4n <SEP> (5) <SEP> <tb> aromatic <SEP> CO <SEP> CHCH <SEP> H <SEP> S <SEP> 0.2-1 <SEP> 4go(1.5) <SEP> 60S(3) <tb> <SEP> cAc <tb> aromatic <SEP> H <SEP> H <SEP> 5 2 <SEP> 0.2-1 <SEP> 67S(5) <tb> aromatic <SEP> H <SEP> Ac <SEP> SO2 <SEP> 0.2-1 <SEP> 42'L(5) <tb> TABLE II (CONT'D) PAF Ring A R1 R X PMN Asth. Rat Induced 1 Ka X PMN Astn. Rat Incuced IC50 % Inhibition Hyperagesia (mg/ml) and Dose % Inhibition (mg/kg) and Dose (p.o.) (mg/kg) (p.o.) aromatic H Ac SO 0.2-1 aromatic H Ac 0 0.05-0.5 44%(5) Tr.e pharmaceutical compositions will contain a sufficient amount of a compound of Formula I in a dosage form suitable for inhibiting the mammalian biosynthesis of leukotrienes or, for the treatment desired. The effective concentration of Formula I compound in the composition will vary as required by the severity of the condition to be treated, the particular compound of Formula I, the mode of administration, dosage form and pharmacological effect and level desired. A general daily dosage of Formula I (for uses other than cytoprotection) will range from about 100 micrograms to 200 mg/kg of body weight. A preferred daily dosage range is from 1 mg/kg to 130 mg/kg and a most preferred dosage range is from 2 mg/kg to 50 mg/kg. For treating pulmonary conditions such as asthma, the mode of administration may be oral, parenteral, by inhalation, by suppository and the like. Suitable oral dosage forms are tablets, elixirs, emulsions, solutions, capsules, including delayed or sustained release capsules and the like. Parenteral dosage forms include solutions, emulsions and the like. Dosage forms for administration by inhalation including sprays, aerosols and the like. These inhalation formulations may be administered in metered doses ranging from about 0.1 micrograms to about 200 micrograms, administered as needed. For treating allergies or allergic reactions, such as allergic conjunctivitis, allergic rhinitis and the like, the Formula I compound may be administered by any conventional mode, e.g. orally, parenterally, topically, subcutaneously, by inhalation and the like. The oral and parenteral dosage forms are the same type as for the pulmonary treatment. The topical application dosage forms include ointments, salves, controlled release patches, emulsions, solutions, thixotropic formulations, powders, sprays and the like. For topical application, the percent by weight of the active ingredient (Formula I compound) may vary from about 0.001 to about 10%. For treating inflammation the mode of administration may be oral, parenteral, by suppository and the like. The various dosage forms are the same as those described above. For treating skin diseases such as psoriasis, atopic dermatitis and the like, oral, topical or parereral administration is useful. For topical application to the diseased area salves, patches, controlled release patches, emulsions, etc., are convenient dosage forms. For use as an analgesic, i.e. for treating pain, any suitable mode of administration may be used, e.g., oral, parenteral, by insufflation, by suppository and the like. For treating cardiovascular conditions such as angina pectoris, etc., any suitable mode of administration, e.g. oral, parenteral, topical, insufflation, etc. and dosage form e.g. pills, liquid formulations, controlled release capsules, controlled release skin patches, etc. may be used. In addition to the common dosage forms set out above, the compound of Formula I may also be administered for the various utilities and indications or for inhibiting leukotriene synthesis by controlled release means and/or delivery devices such as those described in U.S. 3,845,770; U.S. 3,916,899; U.S. 3,536,809; U.S. 3,598,123; U.S. 3,630,200 and U.S. 4,008,719. Dosage forms for application to treat the eye are also disclosed in U.S. 4,348,398. In preparing suitable dosage forms, conventional compounding procedures and ingredients e.g. diluents, carriers, etc. may be used. Two assays can be used to measure cytoprotective ability. These assays are; (A) an ethanolinduced gastric ulcer assay and (B) an indomethacin-induced ulcer assay. A. Ethanol-Induced Gastric Ulcer Assay Twenty-four hour fasted Sprague-Dawley (S.D.) rats are perorally (p.o.) dosed with 1.0 ml absolute ethanol. Fifteen minutes prior to ethanol administration, groups of rats each receive either an aqueous vehicle (aqueous methylcellulose 5% wt.) or the test compound at various doses perorally. One hour later, the animals are sacrificed and stomach mucosae are examined for resulting lesions. B. Indomethacin-Induced Ulcer Assay Indomethacin, 10 mg/kg p.o., is used to induce ulcers in 24 hour fasted S.D. rats. Fifteen minutes prior to indomethacin administration, groups of rats each receive either an aqueous vehicle (5% by weight methylcellulose) or the test compound at various doses perorally. Four hours later the animals are sacrificed and stomach mucosae are examined for resulting ulcers. As cytoprotective agents, the compounds of Formula I may generally be administered at a dosage range of 0.02 mg/kg to 100 mg/kg of body weight. The exact amount of inhibitor to be used will depend on, inter alia, whether it is being administered to heal damaged cells or to avoid future damage, on the nature of the damaged cells (e.g., gastro-intestinal ulcerations vs. nephrotic necrosis), and on the nature of the causative agent. An example of the use of a compound of Formula I in avoiding future damage would be co-administration of a compound of the formula I with a non-steroidal anti inflammatory drug that might otherwise cause such damage (for example, indomethacin). For such use, the compound of Formula I is administered from 30 minutes prior up to 30 minutes after administration cf the NSAID. Preferably, it is administerec prior to or simultaneously with the NSAID (for example, in a combination dosage form). The effective daily cosage level for compounds of Formulae I inducing cytoprotection in mammals, especially humans, will range from about 0.02 mg/kg to about 100 mg/kg, preferably from about 0.02 mg/kg to about 30 mg/kg. The dosage may be administered in single or divided individual doses, using various dosage forms, as described above. The pharmaceutical compositions of the present invention comprise a compound of formula I as an active ingredient or a pharmaceutically acceptable salt thereof, and may also contain a pharmaceutically acceptable carrier and optionally other therapeutic ingredients. The compositions include compositions suitable for oral, rectal, ophthalmic, pulmonary, nasal, dermal, topical or parenteral (including subcutaneous, intramuscular and intravenous) administration, although the most suitable route in any given case will depend on the nature and severity of the conditions being treated and on the nature of the active ingredient. They may be conveniently presented in unit dosage form and prepared by any of the methods well-known in the art of pharmacy. For administration by inhalation, the compounds of the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebuliser. The preferred composition for inhalation is a powder which may be formulated as a cartridge from which the powder composition may be inhaled with the aid of a suitable device. In the case of a pressurized aerosol, the dosage unit may be determined by providing a valve to deliver a metered amount. In practical use, leukotriene inhibitors of Formula I can be combined as the active ingredient in intimate admixture with a pharmaceutical carrier according to conventional pharmaceutical compounding techniques. The carrier may take a wide variety of forms depending on the form of preparation desired for administration, e.g., oral or intravenous. In preparing the compositions for oral dosage form, any of the usual pharmaceutical media may be employed, such as, for example, water glycols, oils, alcohols, flavoring agents, preservatives, coloring agents and the like in the case of oral liquid preparations, such as, for example, suspensions, elixirs and solutions; or carriers such as starches, sugars, diluents, granulating agents, lubricants, binders, disintegrating agents and the like in the case of oral solid preparations such as, for example, powders, capsules and tablets. Because of their ease of administration, tablets and capsules represent the most advantageous oral dosage unit form, in which case solid pharmaceutical carriers are obviously employed. If desired, tablets may be sugar coated or enteric coated by standard techniques. In addition to the common dosage forms set out above, the compounds of Formula I may also be administered by controlled release means and/or delivery devices such as those described in U.S. Patent Nos. 3,845,770; 3,916,899; 3,536,809; 3,598,123; 3,630,200 and 4,008,719, the disclosure of whcih is hereby incorporated herein by reference. Pharmaceutical compositions of the present invention suitable for oral administration and by inhalation in the case of asthma therapy may be presented as discrete units such as capsules, cachets or tablets each containing a predetermined amount of the active ingredient, as a powder or granules or as a solution or a suspension in an aqueous liquid, a non-aqueous liquid, an oil-in-water emulsion or a water-in-oil liquid emulsion. Such compositions may be prepared by any of the methods of pharmacy but all methods include the step of bringing into association the active ingredient with the carrier which constitutes one or more necessary ingredients. In general, the compositions are prepared by uniformly and intimately admixing the active ingredient with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product into the desired presentation. For example, a tablet may be prepared by compression or molding, optionally with one or more accessory ingredients. Compressed tablets may be prepared by compressing in a suitable machine, the active ingredient in a free-flowing form such as powder or granules, optionally mixed with a binder, lubricant, inert diluent, lubricating, surface active or dispersing agent. Molded tablets may be made by molding in a suitable machine, a mixture of the powdered compound moistened with an inert liquid diluent. Desirably, each tablet contains from about 25 mg to about 500 mg of the active ingredient and each cachet or capsule contains from about 25 to about 5c0 mg of the active ingredient. The following are examples of representative pharmaceutical dosage forms for the compounds of Formula I: Injectable Suspension mg/ml Compound of Formula I 2.0 Methylcellulose 5.0 Tween 80 0.5 Benzyl alcohol 9.0 Methyl paraben 1.8 Propyl paraben 0.2 Water for injection to a total volume of 1 ml Tablet mg/tablet Compound of Formula I 25.0 Microcrystalline Cellulose 325.0 Providone 14.0 Microcrystalline Cellulose 90.0 Pregelatinized Starch 43.5 Magnesium Stearate 2.5 500 Capsule mg/capsule Compound of Formula I 25 Lactose Powder 573. 5 Magnesium Stearate 1.5 600 In addition to the compounds of Formula I, the pharmaceutical compositions of the present invention can also contain other active ingredients, such as cyclooxygenase inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), peripheral analgesic agents such as zomepirac diflunisal and the like. The weight ratio of the compound of the Formula I to the second active ingredient may be varied and will depend upon the effective dose of each ingredient. Generally, an effective dose of each will be used. Thus, for example, when a compound of the Formula I is combined with an NSAID the weight ratio of the compound of the Formula I to the NSAID will generally range from about 1000:1 to about 1:1000, preferably about 200:1 to 1:200. Combinations of a compound of the Formula I and other active ingredients will generally also be within the aforementioned range, but in each case, an effective dose of each active ingredient should be used. NSAIDs can be characterized into five groups: (1) the propionic acid derivatives; (2) the acetic acid derivatives; (3) the fenamic acid derivatives; (4) the biphenylcarboxylic acid derivatives; and (5) the oxicams or a pharmaceutically acceptable salt thereof. The propionic acid derivatives which may be used comprise: ibuprofen, ibuprufen aluminum, indoprofen, ketoprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen and bucloxic acid. Structurally related propionic acid derivatives having similar analgesic and anti-inflammatory properties are also intended to be included in this group. Thus, "propionic acid derivatives" as defined herein are non-narcotic analgesicz/non-steroidal anti-inflammatory drugs having a ree -CH(CH3)COOH or -CH2CH2COOH group (which optior.ally can be in the form of a pharmaceutically acceptable salt group, e.g., -CH(CH3)COONa+ or -CH2CH2COONa+), typically attached directly or via a carbonyl function to a ring system, preferably to an aromatic ring system. The acetic acid derivatives which may be used comprise: indomethacin, which is a preferred NSAID, sulindac, tolmetin, zomepirac, diclofenac, fenclofenac, alclofenac, ibufenac, isoxepac, furofenac, tiopinac, zidometacin, acemetacin, fentiazac, clidanac, oxpinac, and fenclozic acid. Structually related acetic acid derivatives having similar analgesic and antiinflammatory properties are also intended to be encompassed by this group. Thus, "acetic acid derivatives" as defined herein are non-narcotic analgesics/non-steroidal antiinflammatory drugs having a free -CH2COOH group (which optionally can be in the form of a pharma ceutically acceptable salt group, e.g. CH -CH2COO Na+), typically attached directly to a ring system, preferably to an aromatic or heteroaromatic ring system. The fenamic acid derivatives which may be used comprise: mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid and tolfenamic acid. Structurally related fenamic acid derivatives having similar analgesic and anti-inflammatory properties are also intended to be encompassed by this group. Thus, "fenamic acid derivatives" as defined herein are non-narcotic analgesics/non-steroidal antiinflammatory drugs which contain the basic structure: EMI36.1 which can bear a variety of substituents and in which the free -COOH group can be in the form of a pharmaceutically acceptable salt group, e.g., -COO Na+. The biphenylcarboxylic acid derivatives which can be used comprise: diflunisal and flufenisal. Structurally related biphenylcarboxylic acid derivatives having similar analgesic and anti-inflammatory properties are also intended to be encompassed by this group. Thus, 1,biphenylcarboxylic acid derivatives" as defined herein are non-narcotic analgesics/nonsteroidal anti-inflammatory drugs which contain the basic structure: EMI37.1 which can bear a variety of substituents and in which the free -COOH group can be in the form of a pharmaceutically acceptable salt group, e.g., -COO Na The oxicams which can be used in the present invention comprise: . piroxicam, sudoxicam, isoxicam and 4-hydroxyl-1,2-benzothiazine l,l-dioxide 4-(Nphenyl)-carboxamide. Structurally related oxicams having simiar analgesic and anti-inflammatory properties are also intended to be encompassed by this group. Thus, "oxicams" as defined herein are nonnarcotic analgesics/non-steroidal anti-inflammatory drugs which have the general formula: EMI37.2 wherein R is an aryl or heteroaryl ring system. The following NSAIDs may also be used: acemetacin, alminoprofen, amfenac sodium, aminoprofen, anitrazafen, antrafenine, auranofin, bendazac lysinate, benzydamine, beprozin, broperamole, bufezolac, carprofen, cinmetacin, ciproquazone, clidanac, cloximate, dazidamine, deboxamet, delmetacin, detomidine, dexindoprofen, diacerein, di-fisalamine, difenpyramide, emorfazone, enfenamic acid, enolicam, epirizole, etersalate, etodolac, etofenamate, fanetizole mesylate, fencldfenac, fenclorac, fendosal, fenflumizole, fentiazac, feprazone, floctafenine, flunixin, flunoxaprofen, fluproquazone, fopirtoline, fosfosal, furcloprofen, furofenac, glucametacin, guaimesal, ibuproxam, isofezolac, isonixim, isoprofen, isoxepac, isoxicam, lefetamine HC1, leflunomide, lofemizole, lonazolac calcium, lotifazole, loxoprofen, lysin clonixinate, meclofenamate sodium, meseclazone, miroprofen, nabumetone, nictindole, nimesulide, orpanoxin, oxametacin, oxapadol, oxaprozin, perisoxal citrate, pimeprofen, pimetacin, piproxen, pirazolac, pirfenidone, pirprofen, pranoprofen, proglumetacin maleate, proquazone, pyridoxiprofen, sudoxicam, suprofen, talmetacin, talniflumate, tenoxicam, thiazolinobutazone, thielavin B, tiaprofenic acid, tiaramide HC1, tiflamizole, timegadine, tioxaprofen, tolfenamic acid, tolpadol, tryptamid, ufenamate, and zidometacin. The following NSAIDs, designated by company code number, may also be used: 480156S, AA861, AD1491, AD1590, AFP802, AFP860, AHR6293, AI77B, AP504, AU8001, BAYo8276, BPPC, BW540C, BW755C, CHINOIN 127, CN100, C0893XX, CPP, D10242, DKA9, DV17, EB382, EGYT2829, EL508, F1044, FZ, GP53633, GP650, GV3658, HG/3, ITC1, ITF, ITF182, KB1043, KC8973, KCNTEI6090, KME4, LA2851, LT696, LU20884, M7074, MEDl5, MG18311, MR714, MR897, MY309, NO164, ONO3144, PR823, PV102, PV108, QZ16, R830, RS2131, RU16029, RU26559, RUB265, SCR152, SH440, SIR133, SIR136, SIR92, SPAS510, 5027239, ST281, SX1032, SY6001, SaH46798, TA60, 'rAI901, TEI615, TVX2706, TVX960, Tri615, U60257, UR2310, WY23205, WY41770, YM09561, YM13162, YS1033, and ZK31945. Finally, NSAIDs which may also be used include the salicylates, specifically aspirin, and the phenylbutazones, and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising the Formula I compounds may also contain other inhibitors of the biosynthesis of the leukotrienes such as are disclosed in pending U.S. Patent Applications Serial Number 539,342, filed October 5, 1983, Serial Number 459,924, filed January 21, 1983, Serial Number 539,215, filed October 5, 1983, and Serial Number 547,161, filed October 31, 1983, which are hereby incorporated herein by reference. The compounds of the Formula I may also be used in combination with leukotriene antagonists such as those disclosed in copending applications U.S. Serial Nos. 520,051 and 520,052, filed August 5, 1983 which are hereby incorporated herein by reference and others known in the art such as those disclosed in European Patent Application Nos. 56,172 and 61,800; and in U.K. Patent Specification No. 2,058,785, which are hereby incorporated herein by reference. Pharmaceutical compositions comprising the Formula I compounds may also contain as the second active ingredient, antihistaminic agents such as benadryl, dramamine, histadyl, phenergan and the like. Alternatively, they may include prostaglandin antagonists such as those disclosed in European Patent Application 11,067 or thromboxane antagonists such as those disclosed in U.S. 4,237,160. They may also contain histidine decarboxyase inhibitors such as a-fluoromethylhistidine, described in U.S. 4,325,961. The compounds of the Formula I may also be advantageously combined with an H1 or H2-receptor antagonist, such as for instance cimetidine, ranitidine, terfenadine, famotidine, aminothiadiazoles disclosed in EP 81102976.8 and like compounds, such as those disclosed in U.S. Patent Nos. 4,283,408; 4,362,736; 4,394,508; European Patent Application No. 40,696 and a pending application, U.S.S.N. 301,616, filed September 14, 1981. The pharmaceutical compositions may also contain a K /H ATPase inhibitor such as omeprazole, disclosed in U.S. Pat. 4,255,431, and the like. Each of the references referred to in this paragraph is hereby incorporated herein by reference. Another embodiment of the present invention are the novel compounds and their pharmaceutically acceptable salts, encompassed by Formula I. These compounds are described in Table III. The number preceding the R2-R5 definitions signifies that group's position on the ring system. TABLE III NOVEL COMPOUNDS OF FORMULA I EMI41.1 a X Ring A R1 R2 R3 R4 R5 1.1 S aromatic H 5-OCOCH3 H H H 2. S aromatic CH3 5-OCH3 H H H 3. S aromatic CH3 5-OCOCH3 H H H 4. 5 aromatic COCH3 5-OH H H H 5. S aromatic COCH3 5-OCH3 H H H 6. S aromatic H 5-OCOCH2NH2 H H H 7. 5 1,4-dihydro H 5-OH H H H 8. S aranatic H 5-OCOCH(CH3)2 H H H 9. S aranatic H 5-OCOC(CH3)3 H H H 10. S aromatic H 5-OCOC6H5 H H H a The symbol 1 mext to the number of a compound indicated which compounds are preferred. TABLE III (CONT'D) Compound a X Ring A R1 R2 R3 R4 R 11. S atomatic H 5-OH 6-CH3 H H 12. S aromatic H 5-OCOCH3 6-CH3 H H 13. S aranatic H 5-OH 1-OH 6-CH3 H 14. S atomatic H 5-OCOCH3 1-OH 6-CH3 H 15. S atomatic H 5-OH 1-OCH3 6-CH3 H 16. s aranatic H 5-OCOCH3 1-OCH3 6-CH3 H 17. S aromatic H 5-OCOC(CH3)3 1-OCH3 6-CH3 H 18. S 1,4-dihydro H 5-OCOCH3 H H H 19. SO aromatic H 5-OCOCH3 H H H 20. SO2 aromatic H 5-OCOCH3 H H H 21. 50 aromatic H 5-OH H H H 22. 502 aromatic H 5-OH H H H 23. 5 aromatic H 5-OCH2OCH3 H H H 24. 5 aromatic H 5-OCH3 H H H 25. 5 aromatic COCH 5-OCOCH3 H H H TABLE III (CONT'D) EMI43.1 <SEP> 0 <SEP> 2 <SEP> 3 <SEP> 4-5 <tb> caippund <SEP> X <SEP> Ring <SEP> A <SEP> R <SEP> R <SEP> R <SEP> R <SEP> R <tb> 26. <SEP> 5 <SEP> aromatic <SEP> CH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> 27.1 <SEP> 5 <SEP> aromatic <SEP> CO2CHCH3 <SEP> 5-0H <SEP> H <SEP> H <SEP> H <tb> <SEP> oAc <tb> 28. <SEP> S <SEP> aromatic <SEP> Co <SEP> OCH <SEP> SOAc <SEP> H <SEP> H <SEP> H <tb> <SEP> 2 <SEP> 3 <tb> <SEP> OAc <tb> 29. <SEP> 5 <SEP> aromatic <SEP> C02CHCH3 <SEP> 5-0Co2aHCH3 <SEP> HH <SEP> H <SEP> H <tb> <SEP> OAC <SEP> lLc <tb> 30. <SEP> 5 <SEP> aranatic <SEP> H <SEP> 5-OCo2CHCH3 <SEP> H <SEP> H <SEP> H <tb> <SEP> OAc <tb> 31. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OPO(OEt)2 <SEP> H <SEP> H <SEP> H <tb> 32. <SEP> 5 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9-OHe <SEP> H <SEP> H <tb> 33. <SEP> 5 <SEP> asiatic <SEP> H <SEP> 5-OAc <SEP> we <SEP> H <SEP> H <tb> 34. <SEP> 5 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9-4e <SEP> H <SEP> H <tb> 35. <SEP> 5 <SEP> aromatic <SEP> H <SEP> 56Ac <SEP> 9-14e <SEP> H <SEP> H <tb> 36. <SEP> 5 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9-F <SEP> H <SEP> H <tb> 37. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OAc <SEP> 9-F <SEP> H <SEP> H <tb> 38. <SEP> 5 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 6-CAc <SEP> H <SEP> H <tb> TABLE III (CONT'D) EMI44.1 <tb> Ring <SEP> nd <SEP> X <SEP> ring <SEP> A <SEP> R1 <SEP> R2 <SEP> R3 <SEP> 4 <SEP> R <tb> <SEP> 2 <tb> 39. <SEP> S <SEP> aromatic <SEP> H <SEP> S-OAc <SEP> 6-0Ac <SEP> H <SEP> H <tb> 40. <SEP> S <SEP> aromatic <SEP> Ac <SEP> 5-0H <SEP> 6-OH <SEP> H <SEP> H <tb> 41. <SEP> S <SEP> aromatic <SEP> Ac <SEP> 5-4Ac <SEP> 6-OAc <SEP> H <SEP> H <tb> 42. <SEP> S02 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 6-OH <SEP> H <SEP> H <tb> 43. <SEP> 0 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> 44. <SEP> 0 <SEP> aranatic <SEP> H <SEP> 5-OAc <SEP> H <SEP> H <SEP> H <tb> <SEP> Gc <tb> 45. <SEP> 0 <SEP> aromatic <SEP> C02CHCH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> <SEP> OAc <tb> 46. <SEP> SO2 <SEP> aromatic <SEP> C02CHCH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> 47. <SEP> S <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9-OCH2C02H <SEP> H <SEP> H <tb> 48. <SEP> 5 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> r <SEP> 9H2CO2H <SEP> H <tb> <SEP> c <tb> 49. <SEP> 0 <SEP> aromatic <SEP> C02CHCH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> The compounds of Formula I may be prepared by any process available to the skilled artisan. Several such processes are illustrated in Schemes I to IV below. SCHEME I EMI45.1 SCHEME I (Continued) EMI46.1 SOHEME II EMI47.1 SCHEME III (Continued) EMI48.1 where: Rd is C1 to C4 alkyl or phenyl; Re is a residue such that the reagent EMI49.1 is a derivative of an essential amino acid; m is 1 or 2; n is 0 to 3; to C1 lower alkyl, Rf is hydrogen, C1 C1 to C6 acyloxy or hydroxy; Rg is C1 to C5 lower alkyl or benzyl; Z is Cl. Br, I, tosylate or mesylate. M.S.4.A is 4 Angstrom molecular sieves; and MCPBA is m-chloroperbenzoic acid. SCHEME IV EMI50.1 SCHEME IV (Continued) EMI51.1 Reaction of a napthoquinone IV, optimally two equivalents, with a 2-aminobenzenethiol V, in a solvent such as acetic acid, acetic acid-water, or a lower alkanol at from -200 to +600C for 0.25 to 6 hours yields the benzo[a]phenothiazin-5-one VI. Preferably, the solvent is methanol or ethanol, at 0 to 250C for 0.5 to 2 hours. Reduction of VI to VII is carried outwith a reducing agent such as sodium hydrosulfite in a suitable solvent system by stirring at from 100 to 50 C (preferably at room temperature) for 1 to 12 hours (preferably 1 to 4 hours) . The solvent system may be a homogeneous one such as dimethylformamide-water or dichlormethane-water (Scheme I). The O-acyl compounds VIII are prepared by reacting compound VII with the desired acid anhydr-de in pyridine at a temperature of from -250 to +750C (preferably 0 to 500C) for from 1 hour to 24 hours (preferably 4 to 15 hours) (Scheme I). The O-aminoacyl compounds IX are prepared from VIII by reacting the latter with a N-blocked amino acid and dicyclohexylcarbodiimide (DCC), followed by removal of the blocking group by treatment with HC1 (Scheme I). The N-acyl compound X can be prepared from VII by reacting the latter with an acyl halide, such as acetyl chloride, in a solvent such as dimethyl formamide at from 0 to 500C (preferably room temperature) for from 0.5 to 4 hours depending on the rate of reaction of the particular components (Scheme I). To obtain the N,O-dialkyl compounds XI compound VIII is reacted with an alkyl halide or a methyl sulfonate (preferably an alkyl iodide) in the presence of a strong base such as sodium hydride or potassium t-butoxide in a solvent such. as tetrahydrofuran or dimethylformamide at 0 to ±()' (preferably room temperature) for from 1 to 24 hours (preferably 1 to 10 hours). In this same reaction, some of the N-alkyl-O-acyl compound XII is also obtained, and is separated from XI by chromatography. The N-acyl-O-alkyl compounds XIII are prepared from compound X by a procedure similar to that used to prepare XI and XII (Scheme I). The sulfoxide derivative XIV (m=l) are prepared by treating VIII with peracid such as peracetic acid or meta-chloroperbenzcic acid (MCPBA) in a solvent such as methylene chloride or methylene chloride-methanol for 0.5 to 4 hours at 0 to 300C. The sulfones XIV (m=2) are obtained ty reacting VI IT with a peracid in methylene chloride-methanol, or preferably 1,2-dichloro-ethane-ethancl, at reflux temperature of the mixture for 12 to 24 hours, depending upon the rate of reaction. Hydrolysis of XIV to XV is carried out by reaction with a base (;or example LiOH, NaOH or KOH) in a mixed solvent such as methanol-water or ethanol-water, at from 0 to 60 C (preferably room temperature) for from 5 minutes to 180 minutes (preferably 10 minutes to 90 minutes) (Scheme II). To prepare a carbamate derivative such as XVII, compound VII is reacted with the appropriate chloroformate reagent in a suitable solvent such as tetrahydrofuran, dioxane or preferably acetonitrile and the mixture heated to reflux for 4 to 24 hours. Reaction of the appropriate chloroalkylcarbamate XVII with a metal salt of a carboxylic acid then yields the acyloxyalkoxycarbonyl compound XVIII. Preferred salts are those of silver, mercury (II) or sodium, using the corresponding free acid as a solvent, and heating the reaction mixture at 0 to 1000C for from 10 minutes to 2 hours (Scheme III). The 1,4-dihydro series of compounds (XX) is prepared by condensing a 2-amino benzenethiol V with diketone XIX under conditions similar to those used for the reaction between IV and V. Preparation of compounds XXI to XXVI is carried out by methodology very similar to that described in Scheme I to obtain compounds VIII to XIII (Scheme IV). Some of the benzo[a]-phenothiazin-5-one derivatives used as starting materials are described in our co-pending applications U.S. Serial No. 591,134, filed March 19, 1984 (Attorney Docket No. 16876IC) and European Patent Application 84300239.5, published on August 8, 1984 under publication number 0115394 (Attorney Docket No. 16876Y). The disclosure of these applications is hereby incorporated herein by reference. It will be evident to one skilled in the art that R2 must be chosen so as to be compatible with the reaction outlined in Schemes I to IV. The following examples are provided to aid in the interpretation of the claims appearing below. They are not intended as a limitation upon the scope of said claims. All temperatures are reported in degrees Celsius (OC) and are uncorrected. EXAMPLE 1 Preparation of 5-acetoxy-12H-benzo[a]phenothiazine Acetic anhydride (2 ml) was added to a solution of 5-hydroxy-12H-benzo[a]phenothiazine (1 (1.4 gm) in pyridine (10 ml) and stirred for 15 minutes. The reaction mixture was concentrated under vacuum and ice-water was added to the residue. The resulting precipitate was filtered, air-dried and washed with ethyl acetate to afford the title compound. m.p. 184-5 Anal. C18H 3NO2S Calcd.: C, 70.34; H, 4.26; N, 4.56; S, 1'.43. Found: C, 70.28; H, 4.32; N, 4.53; S, 10.51. Ref. (1): C.A. 70:69169z. S. African 6801,996. XAMPLE 2 Preparation of 5-methoxy-12-methyl-12H-benzo[a] phenothiazine and 5-acetoxy-12-methyl-12H-benzo[a]- phenothiazine Potassium tert. butoxide (1.3 gm) was added to a solution of 5-acetoxy-12H-benzo[a]phenothiazine (from Example 1) (2.0 gm) and methyl iodide (4 ml) in DMF (20 ml). The reaction mixture was cooled with an ice-bath and stirred for 15 minutes. Diethyl ether (100 ml) was added to the reaction mixture followed by brine (100 ml). The ether layer was decanted, washed with brine, dried and evaporated to dryness. The resulting oily residue was chromatographed on silica gel (10% EtOAc/hexane) to afford 5-methoxy-12methyl-12H-benzo[a]phenothiazine. M.P. 123-40, Anal. C18H15NOS Calcd.: C, 76.69; H, 5.15; N, 4.77; S, 10.93. Found: C, 73.64; H, 5.30; N, 4.71; S, 11.00 followed by 5-acetoxy-12-methyl-12H-benzo[a] phenothiazine. m.p. 109-110 Anal. C19H15NO2S Calcd.: C, 71.01; H, 4.70; N, 4.36; S, 9.98. Found: C, 71.25; H, 4.90; N; 4.26; S, 10.12. EXAMPLE 3 Preparation of 12-acetyl-5-hydroxy-12H-benzofal phenothiazine Acetyl chloride (2 ml) was added to a solution of 5-hydroxy-12H-benzo[a]phenothiazine (1) (2.65 gm) in DMF (10 ml) and stirred for 30 minutes. Diethyl ether (100 ml) was added to the reaction mixture followed by ice-water (50 ml). The aqueous layer was decanted and the organic layer containing a solid was evaporated to dryness. The resulting residue was treated with acetone and filtered to afford the title compound. m.p. 2300. Anal. C18H13NO2S. Calcd.: C, 70.34; H, 4.26; N, 4.56; S, 10.43. Found: C, 70.43; H, 4.38; N, 4.55; S, 10.62. Ref. (1): C.A. 70:69169z. S. African 6801,966. EXAMPLE 4 Preparation of 12-Acetyl-5-methoxy-12H-benzota] phenothiazine Potassium tert-butoxide (800 mg) was added to a solution of 12-acetyl-5-hydroxy-12H-benzo[a]- phenothiazine (950 mq) (from Example 3) and methyl iodide (1.5 ml) in DMF (10 ml) and stirred for 15 minutes. Water (80 ml) was added to the reaction mixture and the precipitate was filtered to afford the title compound. m.p. 208-90 Anal. ClgHl5NO2S Calcd.: C, 71.01; H, 4.70; N, 4.36; S, 9.98. Found: C, 70.97; H, 4.84; N, 4.SO; S, 10.07. EXAMPLE 5 Preparation of 5-aminoacetoxy-12H-benzo[a]phenothiazine-hvdrochloride salt Dicyclohexylcarbodiimide (21 g) was added to a solution of 5-hydroxy-12H-benzo[a]phenothiazine (4.2 g) and N-tert-butyloxycarbonyl glycine (8.4 g) in THF (150 ml) followed by the addition of DMAP (0.2 The reaction mixture was stirred for 15 minutes, filtered and the filtrate evaporated to dryness. The residue was dissolved in EtOAc, washed with a solution of NaHCO3, dried and evaporated to dryness. The resulting oily residue was chromatographed on silica gel (5% EtOAc/CH2C12) to afford 5-tert-butyloxycarbonylamino acetoxy-12H-benzo[a]phenothiazine. m.p. 1750 as an intermediate. The above intermediate (1 g) was dissolved in CH2C12 (35 ml) cooled to 0 and HC1 (gas) was bubbled into the solution for 15 minutes. The precipitate was filtered to afford the title compound. m.p. 1890 Anal. C18Hl3N202S.HCl Calcd.: C, 60.25; H, 4.21; N, 7.80; S, 8.93; C1, 9.88. Found C, 60.00; H, 4.30; N, 7.90; S, 8.78; C1, 10.16. EXAMPLE 6 Preparation of 5-Hydroxy-1,4-dihydro-12H-benzofa] phenothiazine A solution of 2-aminothiophenol (385 mg) in methanol (3 ml) was added to a solution of 4a, 5, 8, 8a-tetrahydro-1,4-naphtoquinone (Ref.: Ber. 62, 2361 (1929)) (500 mg) in methanol (10 ml) and stirred for 1 hour. Then conc. HC1 (2 ml) was added and the mixture was stirred for another 2 hours. Ethyl acetate was added to the reaction mixture followed by a solution of NaHCO3. The organic layer was decanted, dried and evaporated to dryness. The resulting oily residue was chromatographed on silica gel (CH2C12) to afford the title compound. m.p. 1660 Anal. C16H13NOS Calcd.: C, 71.88; H, 4.90; N, 5.23; S, 11.99. Found: C, 71.74; H, 4.88; N, 5.25; S, 12.17. EXAMPLE 7 Preparation of 5-Hydroxy-6-methyl-l2H-benzo[a] phenothiazine and 5-acetoxy-6-methyl-12H-benzo[a] phenothiazine A solution of sodium hydrosulfite (40 g) in water (0.5 1) was added to a suspension of 6-methyl SH-benzo[a]phenothiazine-5-one (10.4 g) in ethyl acetate (1 1) and.stirred for 2 hours. The organic layer was decanted, dried and evaporated to dryness. The resulting residue was triturated with ether and filtered to afford 5-hydroxy-6-methyl-12H-benzo [a]phenothiazine as an air sensitive solid. The above compound (3 gm) was dissolved in a mixture of pyridine (20 ml) and acetic anhydride (10 ml) and stirred for 15 minutes. The reaction mixture was concentrated under vacuum and the residue triturated with diethyl ether and filtered. A sample was chromatographed on silica gel (CH2C12) to afford the title compound, m.p. 1700, Anal. C19H15N02S Calcd.: C, 71.00; H, 4.70; N, 4.35; S, 9.97. Found: C, 70.95; H, 4.80; N, 4.24; S, 10.14. EXAMPLE 8 Preparation of 5-Benzoyloxy-12H-benzo[a]phenothiazine Following the procedure of Example 1 but substituting benzoic anhydride for acetic anhydride, the title compound was obtained, m.p. 171"C. Anal. C13H15N02S; Calcd.: C, 74.78; H, 4.09; N, 3.79; S, 8.68. Found: C, 74.93; H, 4.22; N, 3.96; S, 8.57. EXAMPLE 9 Preparation of 5-Trimethylacetoxy-12H-benzofaj- phenothiazine Following the procedure of Example 1 but substituting trimethyl acetic anhydride for acetic anhydride, the title compound was obtained, m.p. 1420C. Anal. C21H19NO2S; Calcd.: C, 72.18; H, 5.48; N, 4.01; S, 9.17. Found: C, 72.15; H, 5.46; N, 4.21; S, 9.34. EXAMPLE 10 Preparation of 5-Methoxymethoxy-12H-benzo[a]phenothiazine Sodium hydride (75 mg) was added to a solution of 5-hydroxy-12H-benzo [alphenothiazine (1) (500 mg) and chloromethyl methyl ether (154 mg) in THF (10 ml) and the reaction mixture was stirred for 15 minutes. Diethyl ether (60 ml) was added to the reaction mixture followed by water (60 ml). The ether layer was decanted, dried and evaporated to dryness. The resulting residue was chromatographed on silica gel (CH2C12/hexane (7:3)) to afford the title compound, m.p. 103 C. Anal. C18Hl5NO2S; Calcd.: C, 69.87; H, 4.89; N, 4.53; S, 10.36. Found: C, 69.75; H, 5.01; N, 4.41; S, 10.53. EXAMPLE 11 Synthesis of 5-Acetoxy-12-acetyl-12H-benzo[a]phenothiazine To a mixture of 5-acetoxy-12H-benzo[a]phenothiazine (3.0 g) and powdered 4 Angstrom molecular sieves (7.5 g) in 1,2-dichloroethane (75 ml) there was added slowly acetyl bromide (1.05 ml). The mixture was stirred at room temperature for 1 hour, then filtered. The filtrate was evaporated down to an oil which was triturated with a mixture of ether and hexane to afford solid title product (3 g), m.p. 141-1420C. EXAMPLE 12 Svnthesis of 5-Methoxy-12H-benzoia)phenothiazine To a solution of 5-hydroxy-12H-benzo[a]- phenothiazine (2.65 g) and methyl iodide (2.5 ml) in DMF (dimethylformamide) (10 ml) there was added powdered potassium carbonate (2.0 g). The mixture was stirred at room temperature and after 15 minutes, another addition of potassium carbonate (2.0 g) and methyl iodide (2.0 ml) was done. The mixture was stirred for a further 20 minutes, then it was diluted with ethyl acetate (100 ml and washed with water (60 ml) twice, dried and evaporated down. The residue was triturated with ether to afford solid crude product which was filtered (1.7 g). This crude product was chromatographed on a column of silica gel, eluting with dichloromethane to afford pure title compound (1.33 g), m.p. 168-1700C. EXAMPLE 13 Synthesis of Diethyl 12H-benzo[a]phenothiazin-5-yl phosphate To a solution of 5-hydroxy-12H-benzo[a]phenothiazine (1.5 g) and diethyl chlorophosphate (2 ml) in DMF (20 ml) there was added a powdered mixture of potassium carbonate (2 g) and potassium iodide (2 g). The reaction mixture was stirred at room temperature. After 30 minutes, a further addition of potassium carbonate and potassium iodide (2 g each) was made and stirring was continued. Two hours later more carbonate (2 g) and diethyl chlorophosphate (2 ml) were added, and then three hours later a final addition of carbonate (2 g) was made. The mixture was stirred for 3 days then diluted with ethyl acetate (60 ml) and the insolubles filtered. The filtrate was washed with water, dried and evaporated down. This residue was crystallized from acetone, then chromatographed on a column of silica gel, eluting first with 1:1, then 3:1 mixtures of ethyl acetate and hexane to afford pure title compound (337 mg), m.p. 162-1630C. EXAMPLE 14 Synthesis of 5-Hydroxy-12- (l-acetoxyethoxycarbonyl) - 12H-benzotalphenothiazine Step 1: Preparation of a-Chloroethyl chloroformate To a mixture of ethyl chloroformate (108.5 a) and sulfuryl chloride (138 g), benzoyl peroxide (1 g) was added and it was refluxed for 20 hours. The reaction mixture was distilled and the liquid boiling above 1100 was collected. This was then fractionated using a 30 cm column packed with glass helices to give 32 g of pure alpha-chloroethyl chloroformate, b.p. 118-119 . Step 2: Preparation of 5-Hydroxy-12-(a-chloroethoxy- carbonyl)-12H-benzo[a]phenothiazine A mixture of 5-hydroxy-12H-benzota3pheno- thiazine (5 g) and a-chloroethyl chloroformate (10 g) in tetrahydrofuran (20 ml) was refluxed for 9 hours, then the volatile components were evaporated away and the residue chromatographed on a column of silica gel, eluting with a 1:9 ethyl acetate-hexane mixture to afford the title compound (4 g) as an oil. Step 3: Preparation of 5-Hydroxy-12-(1-acetoxyethoxy carbonyl)-12H-benzo[a]phenothiazine The product from Step 2 (4 g) and sodium acetate (6 g) were refluxed together in glacial acetic acid (60 ml) for 1 hour. The mixture was cooled, diluted with ethyl acetate (300 ml) and washed with water (3 x 100 ml), then with aqueous sodium bicarbonate and again with water, dried and evaporated down. The residue was chromatographed on a column of silica gel eluting with a 1:9 mixture of ethyl acetate-hexane to afford, after trituration in ether and filtration, the pure title compound (1.2 g), m.p. 195-196"C. EXAMPLE 15 Synthesis of 5-Acetoxy-9-methoxy-12H-benzo[a]phenothiazine By following the procedures described in preparative Example 7, but substituting 9-methoxy-5Hbenzo[a]phenothiazine-5-one for the 6-methyl analog as starting material, the title compound was obtained, m.p. 156-1580C. EXAMPLE 16 Synthesis of 5-Acetoxy-9-methyl-12H-benzo[a]phenothiazine By following the procedures described in preparative Example 7, but substituting 9-methyl-SHbenzo[a]phenothiazine-5-one for the 6-methyl analog as starting material, the title compound was prepared, m.p. 193-1950C. EXAMPLE 17 Synthesis of 5-Acetoxy-9-fluoro-12H-benzota]pheno- thiazine By following the procedures described in preparative Example 7, but substituting 9-fluoro-5Hbenzo[a]phenothiazine-5-one for the 6-methyl analog as starting material, the title compound was obtained, m.p. 196-1980C (dec). EXAMPLE 18 Synthesis of 5-Acetoxy-12H-benzo[a]phenoxazine Applying the procedures described in preparative Example 7, but substituting 5H-benzo[a]phenoxazine-5-one for 6-methyl-SH-benzo[a]phenothiazine-5-one, the title compound was synthesized, m.p. 152-1550C. EXAMPLE 19 Synthesis of 5,6-Diacetoxv-12H-benzo[a]phenothiazine By following the procedures described in preparative Example 7, but substituting 6-acetoxy5H-benzo[a]phenothiazine-5-one for the 6-methyl analog as starting material there was obtained the title compound, m.p. 206-207"C. EXAMPLE 20 Synthesis of 12-Acetyl-5,6-diacetoxy-12H-benzo[a]phenothiazine By following the procedure described in preparative Example 11, but substituting 5,6-diacetoxy-12H-benzo[a]phenothiazine for the 5-acetoxy analog as starting material, the title compound was obtained, m.p. 213-2140C. EXAMPLE 21 Synthesis of 12-Acetyl-5,6-dihydroxy-12H-benzo[a]- phenothiazine To a suspension of 12-acetyl-5,6-diacetoxy12H-benzo[a]phenothiazine (450 mg) in acetone (10 ml) there was added 2N aqueous sodium hydroxide solution (10 ml) and the resulting mixture was stirred at room temperature for 45 minutes. It was then made slightly acidic by the addition of 10% aqueous acetic acid solution and the insolubles filtered and washed with water. The solid was swished in ethyl acetate to afford pure title compound (100 mg), m.p. 258-2600C. EXAMPLE 22 Synthesis of 5-Acetoxy-12v-benzo[a]phenothiazine-7- oxide To a suspension of 5-acetoxy-12H-benzo[a]phenothiazine (10 g) in dichloromethane (125 cc) there was rapidly added a solution of 85% m-chloroperoxybenzoic acid (6.61 g) in methanol (125 ml). At first the solids dissolved, then after a few minutes a new solid separated out of solution. After 1 and 1/2 hours the mixture was filtered and the solid washed with dichloromethane. The title compound was thus obtained pure (8.76 g), m.p. 179-1810C. EXAMPLE 23 Synthesis of 5-Acetoxy-12H-benzo [a]phenothiazine-7,7- dioxide To a suspension of 5-acetoxy-12H-benzo[a]phenothiazine (10 g) in dichloromethane (125 ml) there was rapidly added a solution of 85% m-chloro peroxybenzoic acid (18 g) in methanol (125 ml). A solution resulted which rapidly began to deposit the sulfoxide. The mixture was heated to a gentle reflux and slowly the solid redissolved, then the sulfone began to crystallize out of solution. After 2 and 1/2 hours the mixture was allowed to cool down and it was filtered to afford nearly pure title product. A 1 gram sample was crystallized from THF (tetrahydrofuran) to afford pure product (504 mg), m.p. 284-2870C. EXAMPLE 24 Synthesis of 5-Hydroxy-12H-benzo[a]phenothiazine-7,7- dioxide To a suspension of 5-acetoxy-12H-benzo[a]phenothiazine-7,7-dioxide (6.6 g) in methanol (200 ml) there was added 2N aqueous sodium hydroxide solution (132 ml) and the mixture was stirred in the absence of air at room temperature for 7 minutes; at that point an amber solution had resulted. There was rapidly added 10% aqueous acetic acid solution (200 ml) causing precipitation of the title compound which was collected by filtration (5.68 g). A sample (500 mg) was crystallized from THF affording purified product (250 mg), m.p. 3340C (dec). EXAMPLE 25 Synthesis of 5,6-Dihydroxy-12H-benzo[a]phenothiazine 7,7-dioxide To a suspension of 6-hydroxy-SH-benzo[a]- phenothiazine-5-one-7,7-dioxide (430 mg) in water (10 cc) and ethyl acetate (10 ml) there was added sodium dithionite (1 g). The suspension was stirred vigorously at room temperature for 2 hours, then the insolubles were filtered and washed with water and ethyl acetate. There was obtained 346 mg of the title compound, m.p. > 330 C. EXAMPLE 26 Synthesis of 5-Acetoxy-12- (1-acetoxyethoxycarbonyl) - 12H-benzo [a] phenothiazine By following the procedure of Example 1, but substituting the product of Example 14 for 5-hydroxy-12H-benzofa]phenothiazine, the title compound was obtained, m.p. 76-780. EXAMPLE 27 Synthesis of 5-Hydroxy-12-(1-acetoxyethoxycarbonyl) 12H-benzo [a] phenoxazine By following the procedure of Example 14, Steps 2 and 3, but substituting 5-hydroxy-12Hbenzo[a]phenoxazine for 5-hydroxy-12H-benzo[a] phenothiazine, the title compound is obtained. Certain of the compounds of the present invention contain one or more centers of asymmetry. This invention is meant to include both the racemic and the resolved forms of such compounds. Claims to the invention follow.

Claims: CLAIMS 1. A pharmaceutical composition capable of inhibiting leukotriene biosynthesis or action in mammals, especially humans, and containing a pharmaceutically acceptable carrier and a compound having the Formula I or a compound that is a pharmaceutically acceptable salt of a compound of Formula 1: EMI68.1 in which X is 0, S, SO or SO2; R1 is H; C1-6 alkyl; C1-6 acyl; Cl -6 aminoacyl; (C1 -6 acyloxy) (C1 -6 alkyl); (C1 -6 alkoy)-(C1-6 alkyl); benzoyl; substituted benzoyl in which the substitution in the phenyl ring (herein called "substituted as herein defined'1) is halogen, C1-3 alkyl, C1-3 alkoxy, CN, CF3, COOR6, OH, CH2COOR6 or (CH2)nNR8R9 where n is 0, 1 or 2; carbamoyl; CONHR7; COOR7; p-toluenesulfonyl; methane sulfonyl; or an acyl group such that R1 -OH is an essential amino acid; each of R2, R3, R4 and R5, independently of the others, is hydrogen; C1-6 alkyl; C26 alkenyl; -(CHR6)pCOOR6, being 0 or an integer from 1 to 4; or -(CH2)mM where m is 0 or an integer from 1 to 6 and M is (a) OR15; (b) halogen; (c) CF3; (d) SR1 5; (e) phenyl or substituted phenyl as herein DEFINED; (f) COOR6; (g) CO-R14; (h) tetrazolyl; (i) -NH-CO-R7; (j) -NR8R9; (K)-NHSO2R10 where R10 is OH, C1-6 alkyl, C1-6 alkoxy, or phenyl; (I) -COCH2OH; (m) -SOR11 where R11 is C1-6 alkyl; phenyl; substituted phenyl as.herein defined; (CH2)mCOOR6; CN; formyl or C1-4 perfluol-oalkyl; (n)-CONR8R9; (o) -SO2NR8R9; (p) -S02R13 where R13 is a hydrogen atom or a radical of the type defined for Rii; (q) NO2; (r) O-CO-R14; (s) O-CO-NR8R9; (t) -CN; or (u) -OPO(OR6)2; each R6, independently of any other, is H, phenyl or C1 -6 alkyl; each R7, independently of any other, is C1 -6 alkyl, benzyl, phenyl or (C1-6 acyloxy)-(C1-6 alkyl); each R8 and each R9, independently of any other, is phenyl, substituted phenyl as herein defined, or C1-4 alkyl, or -NR8R9 represents a heterocycloalkyl radical of 5 to 8 ring atoms; ; each R14, independently of any other, is H, (CH@)pCOO$6, C1-6 alkyl, C1-6 alkoxy, (C1-6 acyloxy)-(C1-6 alkoxy), phenyl, substituted phenyl as herein defined, or C1 6 aminoalkyl, or R14 is such that R14CO2H is an essential amino acid; R15 is H, (C16 alkoxy)-(C1-6 alkyl), (Cl 6 acyloxy)-(C1-6 alkyl), C1-6 alkyl, benzyl, -(CH2)mCOOR6, CN, formyl, C1-4 perfluoroalkyl, CH2-R12 where R12 is C1-5 aikyldimethylamino or phenyl, phenyl, or substituted phenyl as herein defined; the broken lines in ring A represent optional double bonds; and R2, R3, R4 and R5 may be positioned anywhere in the structure. 2. A composition as claimed in Claim 1, in which the said compounds are of the formula: EMI69.1 in which: Xis O, S, SO or sO; R1 is hydrogen, C1-4 alkyl, C14 acyl, C1-6 aminoacyl, (Cl 6 acyloxy)-(C1-6 alkyl), or COORd where Rd is C1-4 alkyl or (C1-4 acyloxy)-(C1-4 alkyl); each of R2, R3, R4 and R5, independently of the others, is halogen, CH3, CF3, COCH3, Rb, SR6, CH2OH, ORb, COORb or CH2COORb, where each Rb is, independently of any other, H or C1-4 alkyl; and R @@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ (C1-6 acyloxy)-(C1-6 alkyl); C1-4 aminoacyl; carbamoyl; benzyl, substituted benzoyl as herein defined, CONHR where Rc is C1 -4 alkyl; or COORd; or is a structure such that -OR a is an ester of an essential amino acid; and the substituents R2, R3, R4, R5 and ORa may be located anywhere in the molecule. 3. A composition as claimed in Claim 2, in which, in the Formula, X is O or S. 4. A composition as claimed in Claim 2, in which, in the formula, X is S and at least one of R1 and Ra is other than hydrogen. 5. A composition as claimed in Claim 1, in which the compound of formula I has one of the following substituent patterns: X Ring A R1 R2 R3 R4 R5 S aromatic H 5-OH H H H 5 atomatic H 5-OCOCH3 6-Cl H H S aranatic H H H H H S aromatic H 5-OH 6-Cl H H S arcmatic H 5-OH 6-C1 9-C1 H S aromatic H 5-OH 6-Cl 9-OCH3 H S aromatic H 5-OCOCH3 6-C1 9-CH3 H O aromatic H 5-OH H H H O aromatic H 5-OCOCH3 H H H X Ring A R1 R2 R3 R4 R5 SO armatic H 5-OH H H H SO2 armatic H 5-OH H H H SO armatic H H H H H SO2 armatic H H H H H SO armatic COCH3 H H H H S armatic H 1-CO2H H H H S armatic CH3 2-Et H H H S armatic COCH3 2-COCH3 H H H S armatic H 2-COCH3 H H H S armatic H H H H 10-phenyl S armatic H H H 8-CH3 11-CH3 S armatic H H H H 10-COCH3 S armatic H S-OH 6-NHCOCH3 9-F H S armatic H S-OH 6-NH-phenyl 9-Cl H S armatic H 5-OAc 6-Cl H 10-CF3 S armatic H 5-OCH2Ph 6-Cl H 10-CF3 X Ring A R1 R2 R3 R4 R5 S aromatic H 5-OH 6-Cl 9-CH3 11-OH3 S aromatic H 5-OCH3 6-Cl 9-OCH3 H SO2 1,4-di H 5-CH H H H hydro SO2 aromatic COCH3 4-CH3 H 9-SCH3 H O aromatic H H H 9-SO2CF3 H O aromatic H H H 11-CH3 H S aromatic COCH3 S-OCOMe H H H S aromatic CH2OAc 5-OH H H H S aromatic CH2OAc 5-OCOMe H H H H S aromatic Me 5-CH H H H S aromatic H 5-OCOCH3 H H H S aromatic CH3 5-OCH3 H H H S aromatic CH3 5-OCOCH3 H H H S aromatic COCH3 5-OH H H H S aromatic COCH3 5-OCH3 H H H X Ring A R1 R2 R3 R4 R5 S aromatic H 5-OCOCH2NH2 H H H S 1,4-dihydro H 5-OH H H H S aromatic H 5-OCOCH(CH3)2 H H H S aromatic H 5-OCOC(CH3)3 H H H S aromatic H 5-OCOC6H5 H H H S aromatic H 5-OH 6-CH H H 3 S aromatic H 5-OCOCH3 6-CH3 H H S aromatic H 5-OH 1-OH 6-CH3 H S aromatic H 5-OCOCH3 1-OH 6-CH3 H S aromatic H 5-OH 1-OCH3 6-CH3 H S aromatic H 5-OCOCH3 1-OCH3 6-CH3 H S aromatic H 5-OCOC(CH3) 1-OCH3 6-CH3 H S 1,4-dihydro H 5-OCOCH3 H H H SO2 aromatic H 5-OCOCH3 H H H SO aromatic H 5-OCOCH3 H H H SO2 aromatic H S 5-OCOCH3 H H H EMI74.1 <tb> XRinR0 <SEP> A <SEP> R1 <SEP> Rz <SEP> R3 <tb> S <SEP> aromatic <SEP> H <SEP> 5OCX2C)CH3 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5OCH3 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> S)COC <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <tb> <SEP> 64 <tb> S <SEP> aranatic <SEP> H <SEP> 5-OCDC <SEP> H <SEP> -pC1 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-DCOC,H <SEP> -p-HH2 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> S-tXUBC6H4-p-CO2H <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-CXUNC6H4-C4XCF3 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> S-OCOC,H-ml <SEP> 4 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5OCO(CH2)2CO2H <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-0CO(CH2)4C02H <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5COCH(NH2)CH3 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-C(XXCH(NH2)CH2 <tb> <SEP> C6H5 <SEP> H <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> Co <SEP> OCH <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> <SEP> 2t <SEP> a <tb> S <SEP> aromatic <SEP> C02CHCH3 <SEP> 5-OAc <SEP> H <SEP> H <SEP> H <tb> <SEP> c <tb> EMI75.1 <tb> X <SEP> Rinq <SEP> A <SEP> ¯R1- <SEP> -92- <SEP> R3 <SEP> ¯R2 <SEP> P5- <SEP> - <tb> S <SEP> aromatic <SEP> C02ssC > KH3 <SEP> 5CO <SEP> CHai <SEP> H <SEP> H <SEP> H <tb> <SEP> 2 <SEP> 3 <tb> <SEP> OAc <SEP> CAc <tb> S <SEP> aromatic <SEP> H <SEP> SCO <SEP> CHCH3 <SEP> H <SEP> t, <SEP> H <tb> <SEP> 2j <tb> <SEP> CAc <tb> S <SEP> aromatic <SEP> H <SEP> 5-OPO(OEt)2 <SEP> H <SEP> H <SEP> H <tb> <SEP> 2 <tb> S <SEP> arctic <SEP> H <SEP> 5-OH <SEP> 9-OHe <SEP> H <SEP> H <tb> S <SEP> e <SEP> -omatic <SEP> H <SEP> 5-OAc <SEP> 9-OMe <SEP> H <SEP> H <tb> 5 <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9-ffe <SEP> H <SEP> H <tb> 5 <SEP> aromatic <SEP> H <SEP> 5 > 0Ac <SEP> 9-Ne <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 9-F <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-CAc <SEP> 9-F <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-OH <SEP> 6-OAc <SEP> H <SEP> H <tb> S <SEP> aranatic <SEP> H <SEP> 5-CAc <SEP> 6-OAc <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> Ac <SEP> 5-OH <SEP> 6-OH <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> Ac <SEP> 5-OAc <SEP> 6-OAc <SEP> H <SEP> H <tb> SO2 <SEP> araratic <SEP> H <SEP> 5-OH <SEP> 6-OH <SEP> H <SEP> H <tb> EMI76.1 <tb> X <SEP> ¯ <SEP> Ring <SEP> R1 <SEP> A <SEP> R <SEP> , <SEP> R4 <SEP> 4 <tb> <SEP> G4c <tb> 0 <SEP> aromatic <SEP> CDzCHCHa <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> <SEP> CAc <tb> SO2 <SEP> aromatic <SEP> C02CHCH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> 6. A composition as claimed in Claim 1, in which, in the formula, X is 0. 7. A composition as claimed in Claim 1, in which, in the formula, X is S. 8. A composition as claimed in Claim 1, in which, in the formula, X is SO. 9. A composition as claimed in Claim 1, in which, in the formula, X is so2. 10. A composition as claimed in Claim 1, for use in (a) inhibiting mammalian leukotriene biosynthesis or action; (b) treating cardiovascular disorders; (c) treating inflammation; (d) treating allergies; (e) treating pain; or (f) treating psoriasis in a mammal in need of relief. 11. A compound having the Formula: EMI77.1 and one of the following substituent patterns: X Ring A R1 R2 R3 S aromatic H 5-OCOCH3 H H H S aromatic CH3 5-OCH3 H H H S aromatic CH3 5-OCOCH3 H H H S aromatic COCH3 5-OH H H H S aromatic COCH3 5-OCH3 H H H S aromatic H 5-OCOCH2NH2 H H H S 1,4-dihydro H 5-OH H H H S aromatic H 5-OCOCH(CH3)2 H H H S aromatic H 5-OCOC(CH3)2 H H H 5 aromatic H 5-OCOC6H5 H H H X Ring A R1 R2 R3 R4 R5 S aromatic H 5-OH 6-CH3 H H S aromatic H 5-OCOCH3 6-CH3 H H S aromatic H 5-OH 1-OH 6-CH3 H S aromatic H 5-OCOCH3 1-OH 6-CH3 H S aromatic H 5-OH 1-OCH3 6-CH3 H S aromatic H 5-OCOCH3 1-OCH3 6-CH3 H S aromatic H 5-OCOC(CH3)3 1-OCH3 6-CH3 H S 1,4-dihydro H 5-OCOCH3 H H H S aromatic H 5-OCOCH3 H H H SO2 aromatic H 5-OCOCH3 H H H SO aromatic H 5-OH H H H SO2 aromatic H 5-OH H H H S aromatic H 5-OCH2OCH3 H H H S aromatic H 5-OCH3 H H H S aromatic COCH3 5-OCOCH3 H H H S aromatic CH3 5-OH H H H EMI79.1 <tb> X <SEP> Ring <SEP> A <SEP> R <SEP> R <SEP> A <SEP> A <SEP> A <tb> S <SEP> aromatic <SEP> CO <SEP> CHQI <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> <SEP> 2j <SEP> 3 <tb> <SEP> c <tb> S <SEP> aranatic <SEP> CO24CH3 <SEP> 5c <SEP> H <SEP> H <SEP> H <tb> <SEP> QAc <tb> S <SEP> aromatic <SEP> 002CWCH13 <SEP> 54)CO2CHCH(3 <SEP> H <SEP> H <SEP> H <tb> <SEP> QAc <SEP> MC <tb> S <SEP> aromatic <SEP> H <SEP> tic <SEP> 21 <SEP> 3 <SEP> CH, <SEP> H <SEP> H <SEP> H <tb> <SEP> aAc <tb> S <SEP> aromatic <SEP> H <SEP> 5PO(t) <SEP> t)2 <SEP> H <SEP> H <SEP> H <tb> <SEP> 2 <tb> S <SEP> aromatic <SEP> H <SEP> 5-M <SEP> 9-C *e <SEP> H <SEP> H <tb> S <SEP> aranatic <SEP> H <SEP> 5-oAc <SEP> 9OMe <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5 <SEP> 9-Ne <SEP> H <SEP> H <tb> S <SEP> arc'natic <SEP> H <SEP> 5-0Ac <SEP> 9-He <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5'0H <SEP> 9-F <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-a9e <SEP> 9-F <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-oH <SEP> 6-oAc <SEP> H <SEP> H <tb> S <SEP> aromatic <SEP> H <SEP> 5-CAc <SEP> 6-OAc <SEP> H <SEP> H <tb> EMI80.1 <tb> Ring <SEP> A <SEP> R <SEP> 4 <SEP> ¯ <SEP> ¯ <SEP> ¯ <SEP> ¯ <SEP> R3 <SEP> ¯ <SEP> ¯ <SEP> R4 <SEP> R <tb> <SEP> - <SEP> - <SEP> -a-- <SEP> -4 <tb> S <SEP> aromatic <SEP> Ac <SEP> 5-OH <SEP> 6-OH <SEP> H <SEP> H <tb> S <SEP> aronatic <SEP> Ac <SEP> 5-OAc <SEP> 6-OAc <SEP> H <SEP> H <tb> S02aronatic <SEP> H <SEP> 5-OH <SEP> 6-OH <SEP> H <SEP> H <tb> O <SEP> aranatic <SEP> H <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> O <SEP> aromatic <SEP> H <SEP> 5-OAc <SEP> H <SEP> H <SEP> H <tb> <SEP> OAc <tb> O <SEP> arnatic <SEP> 002CHCH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> <SEP> oAc <tb> 502aromatic <SEP> CO2OCH3 <SEP> 5-OH <SEP> H <SEP> H <SEP> H <tb> 12. 5-Acetoxy-12H-benzo[a]phenothiazine. 13. 5 -Hydroxy- I 2-(l -acetoxyethoxycarbonyl)-12H-benzo [a] phenothiazine. 14. 5-Acetoxy-12H-benzo-[a]phenothiazine-7,7-dioxide. 15. 5-Hydroxy-12H-benzo [a] phenothiazine-7,7-dioxide. 16. 5-Acetoxy-12-(1 -acetoxyethoxycarbonyl)-l 2H-benzo [a] phenothiazine. 17. 5-Acetoxy-12H-benzo[a]-phenoxazine. 18. 5-Hydroxy-12-(1-acetoxyethoxycarbonyl)-12H-benzo[a]phenoxazine. 19. A composition as claimed in Claims 1 to 9, containing an effective amount of additional second active ingredient that is a non-steroidal anti-inflammatory drug; a peripheral analgesic agent; a cyclooxygenase inhibitor; a leukotriene antagonist; a leukotriene inhibitor; an H2-receptor antagonist; an antihistaminic agent; a prostaglandin antagonist or a thromboxane antagonist. 20. A composition as claimed in Claim 19, in which the second active ingredient is a non-steroidal anti-inflammatory drug. 21. A composition as claimed in Claim 20, in which the non-steroidal anti-inflammatory drug is indomethacin. 22. A composition as claimed in Claims 19 to 21, in which the weight ratio of the compound defined in Claim 1 to the second active ingredient ranges from 1000:1 to 1:1000. 23. A composition as claimed in Claim 22, in which the said ratio ranges from 200:1 to 1:200.

Inventors: FORTIN, REJEAN, GIRARD, YVES, GUINDON, YVAN, LAU, CHEUK K., ROKACH, JOSHUA, YOAKIM, CHRISTIANE
Applicants: MERCK FROSST CANADA INC.
Application year: 1984
Main classification: A61K31
IPC codes: C07D279, A61K31, A61P29, C07D265, A61P11, A61P9, A61P25, A61P37, C07F9