ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS

Abstract: Compounds of formula I wherein the two groups Ro together form a radical of formula wherein R₂ is hydrogen, C₁₋₄alkyl, C₁₋₄alkoxy (except t-butoxy), trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R₃ is hydrogen, C₁₋₃alkyl, C₁₋₃alkoxy, trifluoromethyl, fiuoro, chloro, phenoxy or benzyloxy, with the pro­ visos that not more than one of R₂ and R₃ is trifluoromethyl, not more than one of R₂ and R₃ is phenoxy, and not more that one of R₂ and R₃ is benzyloxy, R₁ is hydrogen, C₁₋₆alkyl, fluoro, chloro or benzyloxy, R₄ is hydrogen, C₁₋₄alkyl, C₁₋₄alkoxy, (except t-butoxy), trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R₅ is hydrogen, C₁₋₃alkyl, C₁₋₃alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R 5a is hydrogen, C₁₋₂alkyl, C₁₋₂alkoxy, fluoro or chloro, and with the provisos that not more than one of R₄ and R₅ is trifluoromethyl, not more than one of R₄ and R₅ is phenoxy and not more than one of R₄ and R₅ is benzyloxy, X is -(CH₂) n -, wherein n is 0, 1, 2 or 3 and both q's are 0 or one is 0 and the other is 1 wherein R₆ is hydrogen or C₁₋₃alkyl, with the general proviso that -X-Z and the R₄ bearing phenyl are ortho to each other; in free acid form or in the form of a physiologically-­ hydrolysable and -acceptable ester or a δ lactone thereof or in salt form. The compounds possess pharmacological properties and are indicated for use as pharmaceuticals e.g. in inhibiting cholesterol biosynthesis or treating atheroscler­ osis.

Description: ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS The invention concerns naphthalene and tetrahydronaphthalene analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals in particular as hypolipoproteinemic and antiatherosclerotic agents. The invention is especially concerned with compounds of formula I EMI1.1 wherein the two groups Ro together form a radical of formula EMI1.2 wherein R2 is hydrogen, C1 4alkyl, C1 4alkoxy, (except t-butoxy), trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R3 is hydrogen, C1 3alkyl, C1 3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, with the provisos that not more than one of R2 and R3 is trifluoromethyl, not more than one of R2 and R3 is phenoxy, and not more that one of R2 and R3 is benzyloxy, R1 is hydrogen, C1 6alkyl, fluoro, chloro or benzyloxy, R4 is hydrogen, C1 4alkyl, C1-4alkoxy, (except t-butoxy), trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5 is hydrogen, C1 3alkyl, C13alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5a is hydrogen, C1 2alkyl, C1 2alkoxy, fluoro or chloro, and with the provisos that not more than one of R4 and R5 is trifluoromethyl, not more than one of R4 and R5 is phenoxy and not more than one of R4 and R5 is benzyloxy X is -(CH2)n-, EMI2.1 wherein n is 0, 1, 2 or 3 and both q's are 0 or one is 0 and the other is @ EMI2.2 wherein R6 is hydrogen or C1 3alkyl, with the general proviso that -X-Z and the R4 bearing phenyl group are ortho to each other; in free acid form or in the form of a physiologically-hydrolysable and -acceptable ester or a 8 lactone thereof or in salt form. By the term "physiologically-hydrolysable and -acceptable esters is meant an ester of a compound in accordance with the invention in which the carboxyl moiety is esterified, and which is hydrolysable under physiological conditions to yield an alcohol which is itself physiologically acceptable, e.g. nontoxic at desired dosage levels. Preferred such esters as Z can be represented together with the free acid by formula IIa EMI3.1 wherein R7 is hydrogen, Cm 4alkyl or benzyl preferably hydrogen, C1,3alkyl, n-butyl, i-butyl, t-butyl or benzyl and R6 is as defined above. When in salt form R7. represents a cation. When Z is in lactone form it forms a s-lactone of formula IIb EMI3.2 and references to "lactone" hereinafter refer to -lactones. Salts of the compounds of the invention, e.g. of the compounds of formula I, include in particular their pharmaceutically acceptable salts. Such pharmaceutically acceptable salts include e.g. alkali metal salts such as the sodium and potassium salts and ammonium salts. X-Z, R1 and the R4-bearing phenyl ring occupy any of positions 1 to 4 subject to the proviso that X-Z and the R4-bearing phenyl group are ortho to each other. R2 and R3 occupy any of positions 5 to 8. References to compounds of formula I, II and sub-species thereof are intended to cover all forms unless otherwise stated. The compounds of formula I may be divided into two groups, the compounds of formula IA and IB: EMI4.1 wherein R1 to RSa, X and Z are as defined above. The compounds of formula IA may be divided into two subgroups, the compounds wherein Z is a group of formula II in other than lactone form (Group IAa) and those wherein Z is a group of formula IIb(Group IAb). Likewise, the compounds of formula IB may be divided into two sub-groups, the compounds wherein Z is a group of formula II in other than lactone form (Group IBa) and those wherein Z is a group of formula IIb (Group IBb). Each of those four sub-groups may be further divided into three further sub-groups, viz., the compounds wherein the -X-Z group is in the 1-position and the R4-bearing phenyl group is in the 2-position (Groups IAal, IAbl, IBa0 and IBbl), the compounds wherein the -X-Z group is in the 2-position and the R4-bear ing phenyl group is in the l-position (Groups IAa2, IAb2, IBa2, IBb2) and the compounds wherein the -X-Z group is in the 2-position and the R4-bearing phenyl group is in the 3-position (Groups IAa3, IAb3, IBa3 and IBb3). As is self-evident to those in the art, each compound of formula I (and every sub-scope and species thereof) has at least two centers of asymmetry (e.g. the two carbon atoms bearing the hydroxy groups in the group of formula IIa and the carbon atom bearing the hydroxy group and the carbon atom having the free valence in the group of formula IIb) and these lead (e.g. with two centers) to four stereoisomeric forms (enantiomers) of each compound (two racemates or pairs of diastereoisomers). In the preferred compounds having only two such centers of asymmetry these four stereoisomers may be designated as the R, R; R,S; S,R; and S,S enantiomers, all four stereoisomers being within the scope of this invention. Depending on the nature of substituents further asymmetric carbon atoms may be present and the resulting isomers and mixtures thereof also form part of the invention. Compounds containing only two centers of asymmetry (four mentioned stereoisomers) are preferred. R1 is preferably R11, where R1 is hydrogen, C16alkyl not containing an asymmetric carbon atom or chloro, more preferably R1", where R1" is hydrogen or C1 3alkyl, and most preferably R1''', where R1"' is hydrogen, C1-2alkyl or isopropyl. Preferably, R1 (R1' etc.), when other than hydrogen, is in the 3-position in compounds of Groups IAa2 IAb2 IBa2 and IBb2 and in EMI5.1 Alkyl as R2 is preferably C1-3 or n-, i- or t-butyl and alkoxy C1-3 or n- or i-butoxy. R2 is preferably R21, where R2' is hydrogen, C1-3alkyl, C1 3- alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, more preferably R2", where R2" is hydrogen, methyl, methoxy, fluoro or chloro, and most preferably hydrogen. R3 is preferably R31, where R3' is hydrogen, C1 2alkyl, C12- alkoxy, fluoro or chloro, more preferably R3", where R3" is hydrogen, methyl, methoxy, fluoro or chloro, and most preferably hydrogen. Preferably, when both R2 and R3 are other than hydrogen,-at least one of them is in the 6- or 7-position and not more than one of them is a member of the group consisting of t-butyl, trifluoromethyl, phenoxy and benzyloxy. Alkyl as R4 is preferably C1-3 or n-, i- or t-butyl and alkoxy C1-3 or n- or i-butoxy. R4 is preferably R'4, where R41 is hydrogen, C13alkyl, C1 3- alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy. more preferably R4", where R411 is hydrogen, methyl, methoxy, fluoro or chloro, and most preferably R4"', where R4"' is hydrogen or fluoro, especially hydrogen or 4-fluoro and most especially 4-fluoro. R5 is preferably R5', where R5' is hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, more preferably R511, where R5'1 is hydrogen, methyl, methoxy, fluoro or chloro, and most preferably hydrogen. R5a is preferably R5a', where R5' is hydrogen or methyl and most preferably hydrogen. Preferably, when R4 (R4', R411, etc.) is other than hydrogen and R5 (R5', R5", etc.) and R5a (R5a", etc.) are both hydrogen, R4 (R41, etc.) is in a meta or para position, more preferably the para position. The most preferred monosubstituted phenyl group is 4-fluorophenyl. Preferably, when both R4 (R41, R4", etc.) and R5 (R51, R5", etc.) are other than hydrogen and R5a (R5al, etc.) is hydrogen, at least one of R4 (R', etc.) and R5 (R51, etc.) is in a meta or para position (more preferably both are), and not more than one of them is a member of the group consisting of t-butyl, trifluoromethyl phenoxy and benzyloxy; more preferably, R4 (R41, etc.) and R5 (R5', etc.) are not ortho to each other when neither of them is a member of the group consisting of methyl, methoxy, fluoro and chloro. Preferably, when each of R4 (R41, etc.), R5 (R51, etc.) and R5a (R5a', etc.) is other than hydrogen, at least two of them (more preferably all three) are in meta or para positions, and not more than one of them is a member of the group consisting of t-butyl, trifluorQ- methyl, phenoxy and benzyloxy; more preferably, no two of them are ortho to each other unless at least one member of each of the pair of substituents that are ortho to each other is a member of the group consisting of methyl, methoxy, fluoro and chloro. R6 is preferably R6', where R6 is hydrogen or C1-2alkyl, more preferably R6", where R61 is hydrogen or methyl, and most preferably hydrogen. R7 is preferably R7', where R7' is hydrogen or Cl 3alkyl more preferably R7" is hydrogen or C1 2alkyl. Compounds of formula I wherein Z is of formula II or IIa are most preferably in salt form. Preferred salt-forming cations are those free from centers of asymmetry especially e.g. sodium, potassium or ammonium most preferably sodium. X is preferably X', where X' is -(CH2)m or EMI7.1 wherein m is 1, 2 or 3, especially EMI7.2 Z is preferably a group of formula IIa wherein R6 is R6' and R7 is R71 or a group of formula IIb wherein R6 is R61, more preferably a group of formula IIa wherein R6 is R6" and R7 is R7" or a group of formula jib wherein R6 is R6 and most preferably a group of formula IIa wherein R6 is hydrogen and R7 is R7'l or a group of formula IIb wherein R6 is hydrogen, especially a group of formula IIa in sodium salt form wherein R6 is hydrogen or a group of formula IIb wherein R6 is hydrogen. n is preferably m, where m is 1, 2 or 3, preferably 2 or 3 and most preferably 2. Insofar as the compounds of Groups IAa and IBa and each of the sub-groups thereof are concerned, the erythro isomers are preferred over the threo isomers, erythro and threo referring to the relative positions of the hydroxy groups in the 3- and 5-positions (of the group of formula II and IIa). As between otherwise identical compounds of formula I, free acid, salt and ester forms are generally preferred to lactone forms. The trans lactones are generally preferred over the cis lactones, cis and trans referring to the relative positions of R6 and the hydrogen atom in the 6-position of the group of formula IIb. The preferred stereoisomers of the compounds of formula I having only two centers of asymmetry wherein X is a direct bond, EMI8.1 wherein the * denotes the bond to the Z group, and Z is in other than lactone form are the 3R,5S and 3R,5R isomers and the racemate of which each is a constituent, i.e., the 3R,5S-3S,5R (erythro) and 3R,5R-3S,5S (threo) racemates, with the 3R,5S isomer and the racemate of which it is a constituent being more preferred and the 3R,5S isomer being most preferred. The preferred stereoisomers of the compounds of formula I having only two centers of asymmetry wherein X is (CH2!m or EMI8.2 and Z is in other than lactone form are the 3R,5R and 3R,5S isomers and the racemate of which each is a constituent, i.e., the 3R,5R-3S,5S (erythro) and 3R,5S-3S,5R (threo) racemates, with the 3R,5R isomer and the racemate of which it is a constituent being more preferred and the 3R,5R isomer being most preferred The preferred stereoisomers of the compounds of formula I having only two centers of asymmetry wherein X is a direct bond, EMI8.3 wherein the * denotes the bond to the Z group, and Z is a group of Formula IIb are the 4R,6S and 4R,6R isomers and the racemate of which each is a constituent, i.e., the 4R,6S-4S,6R (trans lactone) and 4R,6R-4S,6S (cis lactone) racemates, with the 4R,6S isomer and the racemate of which it is a constituent being more preferred and the 4R,6S isomer being most preferred. The preferred stereoisomers of the compounds of formula I having only two centers of asymmetry wherein X is -(CH2)- or EMI9.1 @@ , and Z is a group of formula IIb are the 4R,6R and 4R,6S isomers and the racemate of which each is a constituent, i.e., the 4R,6R-4S,6S (trans lactone) and 4R,6S-4S,6R (cis lactone) racemates, with the 4R,6R isomer and the racemate of which it is a constituent being more preferred and the 4R,6R isomer being most preferred. The preferences set forth in the preceding four paragraphs also apply to the compounds of formula I having more than two centers of asymmetry and represent the preferred configurations of the indicated positions. Each of the preferences set forth above applies not only to the compounds of formula I, but also to the compounds of formulae IA and IB and those of Groups IAa, lAb, IBa, IBb, IAal, IAa2, IAa3, IAbl, IAb2, IAb3, IBal, IBa2, IBa3, IBbl, IBb2 and IBb3 as well as to every other subgroup thereof set forth infra, e.g. Groups (i) et seq., unless otherwise indicated. When any preference contains a variable, the preferred significances of that variable apply to the preference in question, unless otherwise indicated. Preferred groups of compounds of formula I include the compounds (i) of Group IAal wherein R1 is R1', R2 is R21, R3 is R31, R4 is R41, R5 is R51, R5a is R5a s R6 is R6', R7 is R71, and X is X'. (ii) of (i) wherein when both R2' and R3' are other than hydrogen, at least of of them is in the 6- or 7-position, when both R4' and R51 are other than hydrogen and R5a' is hydrogen, at least one of R4' and R5' is in a meta or para position, and when each of R4', R5' and R5al is other than hydrogen, at least two of them are in meta or para positions, (iii)-(iv) of (i) and (ii) wherein R6 is R6", especially hydrogen. (v)-(vi) of (i) and (ii) wherein R1 is R1", R2 is R2", R3 is R4 is R4", R5 is R5", R5a is hydrogen, R6 is R6", especially hydrogen, R is R," and X is EMI10.1 (vii) of (i) wherein R1 is R1Ul, R2 is hydrogen, R3 is hydrogen, R4 is R4"', R5 is hydrogen, R5a is hydrogen, R6 is hydrogen, R7 is R7", and X is EMI10.2 (viii)-(xiii) of (i)-(vi) wherein any salt form is preferably a sodium, potassium or ammonium, especially a sodium salt form. (xiv) of Group IAbl wherein R1 is R1', R2 is R2', R3 is R3', R4 is R4', R5 is R5', R5a is R5a', R6 is R6', and X is X', (xv) of (xiv) wherein when both R2' and R3' are other than hydrogen, at least one of them is in the 6- or 7-position, when both R4' and R5' are other than hydrogen and R5a' is hydrogen, at least one of R4' and R5' is in a meta or para position; and when each of R4', R5' and R5a' is other than hydrogen, at least two of them are in meta or para positions, (xvi)-(xvii) of (xiv) and (xv) wherein R6 is R6", especially hydrogen, (xviii)-(xix) of (xiv) and (xv) wherein R1 is R1", R2 is R3 is R31E, R4 is R4", R5 is R5 , R5a is hydrogen, R6 is R6", especially hydrogen, and X is EMI10.3 (xx) of (xiv) wherein R1 is R1"', R2 is hydrogen, R3 is hydrogen, R4 is R4"', R5 is hydrogen, R5a is hydrogen, R6 is hydrogen, and X is EMI11.1 (xxi) of Group IBal where-in R1 is R1', R4 is R4', R5 is R5', R5a' e R6 is R6', R7 is R71, and X is X', (xxii) of (xxi) wherein when both R4' and R5' are other than hydrogen and R5a' is hydrogen, at least one of R4' and R5' is in a meta or para position, and when each of R41, R5' and R5a' is other than hydrogen, at least two of them are in meta or para positions, (xxiii)-(xxiv) of (xxi) and (xxii) wherein R6 is R6", especially hydrogen, (xxv)-(xxvi) of (xxi)and (xxii) wherein R1 is R1", R4 is R4", R5 is R5", R5a is hydrogen, R6 is R6ll, especially hydrogen, R7 is and and X is EMI11.2 (xxvii) of (xxi) wherein R1 is R1"', R4 is R4"', R5 is hydrogen, R5a is hydrogen, R6 is hydrogen, R7 is R7", and X is EMI11.3 (xxviii)-(xxxiii) of (xxi)-(xxvi) wherein any salt form is preferably a sodium, potassium or ammonium, especially a sodium salt form. (xxxiv) of Group IBbi wherein R1 is R1', R4 is R4', R5 is R51, R5a is R5a', R6 is R6, and X is XE, (xxxv) of (xxxiv) wherein when both R4' and R5' are other than hydrogen and R5a ' is hydrogen, at least one of R4' and R5' is in a meta or para position, and when each of R4', R51 and R5a' is other than hydrogen, at least two of them are in meta or para positions, (xxxvi)-(xxxvii) of (xxxiv) and (xxxv) wherein R6 is R6", especially hydrogen, (xxxviii)-(xxxix) of (xxxiv) and (xxxv) wherein R1 is Rl'l, R4 is R4", R5 is R5", R5a is hydrogen, R6 is R6", especially hydrogen, and X is EMI12.1 (xl) of (xxxiv) wherein R1 is R1111 R4 is R4"', R5 is hydrogen, R5a is hydrogen, R6 is hydrogen, and X is EMI12.2 (xli)-(lxvi) of (i)-(xiii) and (xxi)-(xxxiii) wherein the hydroxy groups in the 3- and 5-positions (of the group of formula IIa) have the erythro configuration, (lxvii)-(xcii) the 3R,5S enantiomers of the compounds of (xli)-(lxvi) wherein X is EMI12.3 and the 3R,5R enantiomers of the compounds of these groups wherein X is -(CH2)m-, (xciii)-(cvi) of (xiv)-xx) and (xxxiv)-(xl) wherein the hydroxy group on the lactone ring is trans to X (the trans lactones) and (cvii)-(cxx) the 4R,6S enantiomers of the compounds of (xciii) (cvi) wherein X is EMI12.4 and the 4R,6R enantiomers of the compounds of these groups wherein X is -(CH2)m-. Groups of (xli)-(lxvi) embrace the 3R,5S-3S,5R racemate and the 3R,5S and 3S,5R enantiomers of the compounds wherein X is EMI12.5 (the 3S,5R enantiomer being least preferred) and the 3R,5R-3S,5S racemate and the 3R,5R and 3S,5S enantiomers of the compounds wherein X is -(CH2)m- (the 3S,5S enantiomer being least preferred). Groups (xciii)-(cvi) embrace the 4R,6S-4S,6R racemate and the 4R,6S and 4S,6R enantiomers of the compounds wherein X is EMI13.1 (the 4S,6R enantiomer being least preferred) and the 4R,6R-4S,6S racemate and the 4R,6R and 4S,6S enantiomers of the compounds wherein X is -(CH2)m- (the 4S,6S enantiomer being least preferred). Insofar as Groups IAa2, IAb2, IBa2, IBb2, IAa3, IAb3, IBa3 and IBb3 are concerned, the preferred sub-groups are those that correspond to Groups (i)-(cxx). As should be evident, the preferred groups of compounds of Groups IAa2 and IAa3 are those that correspond to Groups (i)-(xiii), (xli)-(liii) and (lxvii)-(lxxix), the preferred groups of compounds of Groups IAb2 and IAb3 are those that correspond to Groups (xiv)-(xx), (xciii)-(xcix) and (cvii)-(cxiii), the preferred groups of compounds of Groups IBa2 and IBa3 are those that correspond to Groups (xxi)-(xxxiii), (liv)-(lxvi) and (lxxx)-(xcii) and the preferred groups of compounds of Groups IBb2 and IBb3 are those that correspond to Groups (xxxiv)-(xl), (c)-(cvi) and (cxiv)-(cxiv) (cxx). It is as if each of these additional groups were set forth herein in its entirety. A particular compound group covers those of formula I wherein the two Ro groups together form a radical of the formula EMI13.2 or -CH2CH2CH2CH2-, wherein R2 is hydrogen, C1 3alkyl, n-butyl, i-butyl, C1 3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R3 is hydrogen, C1 3alkyl, C1 3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, with the provisos that not more than one of R2 and R3 is trifluoromethyl, not more than one of R2 and R3 is phenoxy, and not more than one of R2 and R3 is benzyloxy, R1 is hydrogen, C1-3alkyl, fluoro, chloro or benzyloxy, R4 is hydrogen, Cl 3alkyl, n-butyl, i-butyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5 is hydrogen, C1-3alkyl, Cl 3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R5a is hydrogen, with the proviso that not more than one of R4 and R5 is trifluoro methyl, not more than one of R4 and R5 is phenoxy, and not more than one of R4 and R5 is benzyloxy, X is -(CH2)n-, EMI14.1 wherein n is 0, l, 2 or 3, and EMI14.2 wherein R6 is hydrogen or C1 3alkyl, and R7"' is hydrogen, C1 3alkyl, n-butyl, i-butyl, t-butyl, benzyl or M, wherein M is a pharmaceutically acceptable cation, with the proviso that the -X-Z group and the R4-bearing phenyl group are ortho to each other. The compounds of formula I can be prepared by the following methods whereby represents the basic ring structure EMI15.1 as defined above. EMI15.2 EMI15.3 a) When R6 is hydrogen reducing a compound of formula VI EMI16.1 wherein R14 is a radical forming a physiologically-hydrolysable and acceptable ester and X, is as defined above, b) when Rh = C1-3alkyl, hydrolysing a compound of formula XVII EMI16.2 wherein R6 is Cl 3alkyl, R15 is part of an ester forming group and X and Rl4 are as defined above, c) when X is EMI16.3 deprotecting a compound of formula LIX EMI16.4 wherein Pro is a protecting group d) hydrolysing a compound of formula I in the form of a physiologically hydrolysable ester or a lactone or e) esterifyingorlactonising a compound of formula I in free acid form, and when a free carboxyl group is present, recovering the compound obtcined in free acid form or in the form of a salt. In processes a) and b) R14 is preferably C1 3alkyl, n-butyl, i-butyl, t-butyl or benzyl more preferably C1 3alkyl, most preferably C1 2alkyl and R15 is preferably C1 2alkyl, in particular methyl. It will readily be appreciated that the various forms of the compounds of formula I may interconverted as indicated in d) and e) above. In the same way compounds obtained according to a), b), and c) may be hydrolysed to free acid forms and free acid forms may be esterified or lactonised to produce a desired end-product. The invention thus also provides a process for preparing a compound of formula I which comprises hydrolysing a compound of formula I in ester or lactone form or esterifying or lactonising a compound of formula I in free acid form and when a free carboxyl group is present recovering the compound obtained in free acid form or in the form of a salt. Unless otherwise stated reactions are performed in a manner conventional for the type of reaction involved. Molar ratios and reaction times are as a rule conventional and non-critical and are chosen according to principles well established in the art on the basis of reactants and conditions employed. Solvents, alone or as mixtures, are generally chosen which remain inert and liquid during the reaction in question. Examples of inert atmospheres are carbon dioxide (some reactions) and more usually nitrogen or a nobel gas, nitrogen being preferred. Most reactions, including those wherein use of an inert atmosphere is not mentioned, are carried out under such for convenience. Reduction according to a) is preferably carried out using a mild reducing agent such as sodium borohydride or, a complex of t-butylamine and borane in an inert organic solvent such as a lower alkanol, preferably ethanol, conveniently at a temperature of -10. to 30*C, under an inert atmopshere. Use of an optically pure starting material will lead to only two optical isomers (diastereoisomers) of the resulting end product. However, if stereospecificity is desired it is preferred to utilize a stereoselective reduction in order to maximize production of a mixture of the erythro stereoisomers (racemate) of which the preferred stereoisomer (as set forth above) is a constituent. Stereoselective reduction is carried out in three steps. For example in the first step, the ketoester of formula VLis treated with a tri(primary or secondary C24aIkyl )borane, preferably tri-n-butylborane, and air to form a complex. The reaction temperature is suitably 0 to 50-C, preferably 20- to 30'C. The first step is carried out in an anhydrous inert organic solvent, preferably an ether solvent such as tetrahydrofuran, dimethyl ether, 1,2-dimethoxyethane or 1,2-diethoxyethane, with tetrahydrofuran, being the most preferred solvent. In the second step, for example, the complex is reduced with sodium borohydride, preferably in the same solvent as utilized for the first step, at -80 to -40'C, preferably -80 to -700C. In the third step, the product of the second step is, for example, treated with, aqueous e.g. 30% H202, an aqueous buffer, preferably a phosphate buffer1 two maintain a pH of 7.0 to 7.2, and a lower alkanol preferably methanol. The H202 is in large molar excess e.g. 50 to 70 moles per mole of VI. The reactants are added slowly to the mixture from step 2 at e.g. -800 to -400C preferably -80 to -700C with subsequent warming to 200 to 300C. Hydrolysis according to b) or d) is carried out in a manner conventional for such reactions e.g. employing an inorganic hydroxide such as NaOH or KOH with, if desired subsequent acidification to give the free acid form. Suitable solvents are mixtures of water and water miscible solvents such as lower alkanols e.g. methanol or ethanol and reaction conveniently takes place at temperatures from O C to reflux preferably not more than 800C. most preferably 200 to 300C. If it is desired to recover the compound in a salt form corresponding to the cation of the hydroxide employed then slightly less than equivalent amounts of the latter may be employed. In b) R14will conveniently be the same as R15 e.g. C1,3alkyl, especially C1,2alkyi, preferably methyl. Ladonisation according to e) is carried out in conventional manner e.g. by heating the corresponding acid in an anhydrous inert organic solvent e.g. a hydrocarbon such as benzene, toluene or a xylene or mixtures thereof, preferably at temperatures of 75 C to reflux although more preferably not above 150it. As is evident to those in the art, a racemic threo 3,5-dihydroxycarboxylic acid yields a racemic cis lactone and a racemic erythro 3,5-dihydroxycarboxylic acid yields a racemic trans lactone. Use of a mixture of threo and erythro 3,5-dicarboxylic acid yields a mixture of cis and trans lactones (all four possible diastereoisomers). Likewise if a single enantiomer of the 3,5-dihydroxycarboxylic acid is utilized, a single enantiomer of the lactone is obtained. For example, lactonisation of a 3R,5S erythro dihydroxycarboxylic acid yields a 4R,6S lactone. Esterification according to e) is conventional employing e.g. a large excess of a compound R140H wherein R14 is as defined above at 20'C to 400C optionally in a solvent (especially when R140H is not liquid) and in the presence of a catalytic amount of an acid such as k-toluenesulfonic acid. Where methyl esters are required these can also be obtained e.g. using diazomethane in an anhydrous inert ether solvent such as tetrahydrofuran, 1,2-dimethoxyethane or 1,2-dlethoxyethane and especially diethylether at e.g. 0 to 30 C preferably 20 to 300C. Examples of protecting groups in reaction c) are diphenylt-butylsilyl, tri-isopropylsilyl or dimethyl-t-butylsilyl, C16n-alkyl, benzyl, triphenylmethyl, tetrahydrofuran-2-yl, tetrahydropyran-2-yl, 4-methoxytetrahydropyran-4-yl, Cl¯6n-alkanoyloxy. Especially preferred are trisubstituted silyl radicals in particular diphenyl-t-butylsilyl. Deprotection is carried out in conventional manner e.g. by cleavage under mild conditions such as employing e.g. for removal of a silyl containing group such as diphenyl-t-butylsilyl a fluoride reagent eog. tetra-n-butyl- ammonium fluoride in an anhydrous inert organic medium preferably tetrahydrofuran containing glacial acetic acid at temperagures of 20- to 60'C especially 20- to 30 C. Preferably 1-5 moles of fluoride are used per mole of silyl group with 1 to 1.8 moles of glacial acetic acid to each mole of fluoride. The required starting materials may be prepared for example as illustrated in the following reaction schemes. The symbols used are defined as follows R, R0, R1, R2, R3, R4, R5, R5a, R6, R6a, R11, R12, X, ## = as defined above, M2 = = a cation preferably Na or K R13 = C1-6alkyl preferably C1 2alkyl Y = chloro or bromo Ac = acetyl EMI20.1 [on = OCH3 (LVI), OOH (LVII) or = O (LVIII)3 EMI20.2 * = these substituents are ortho to each other. EMI21.1 # <tb> EMI22.1 REACTION <SEP> SCHEME <SEP> II <SEP> Interconversion <SEP> of <SEP> compounds <SEP> IV <tb> # <tb> EMI23.1 CXXXI <tb> # <tb> Reaction Scheme IV Two isomers of the compound of formula LV may be synthesized by the following series of reactions: EMI24.1 Unless otherwise stated reactions are performed in a manner conventional for the type of reaction involved. Mol ratios and reaction times are as a rule conventional and non-critical and are chosen according to principles well established in the art on the basis of reactants and conditions employed. Solvents alone or as mixtures, are generally chosen which remain inert and liquid during the reaction in question. Examples of inert atmospheres are carbon dioxide (some reactions) and more usually nitrogen or a noble gas, nitrogen being preferred. Most reactions, including those wherein use of an inert atmosphere is not mentioned, are carried out under such for convenince. The following tables give examples of typical reaction conditions. In the reaction schemes temperatures are in degrees centigrade. Abbreviations THF (tetrahydrofuran) DMF (dimethylformamide) LDA (lithium diisopropylamide) DEA (diethylacetamide) BuLi (n-butyllithium) TsOH (p-toluenesulfonic acid) NCS (N-chlorosuccinimide) NBS (N-bromosuccinimide) DIBAH (diisobutylaluminium hydride) DMSO (dimethylsulfoxide) EMI26.1 <SEP> Special <SEP> conditions <tb> Reaction <SEP> Type/Steps <SEP> Reagents <SEP> Temperatures <SEP> Atmosphere <SEP> Solvents <tb> <SEP> 1. <SEP> Strong <SEP> base <SEP> e.g.n-butyl <tb> # <SEP> 1. <SEP> V <SEP> + <SEP> strong <SEP> base <SEP> lithium, <SEP> lithium <SEP> diiso- <SEP> 1. <SEP> -50 <SEP> to <SEP> 10 <SEP> Anhydrous <SEP> e.g. <SEP> THF, <tb> <SEP> 2. <SEP> add <SEP> IV <SEP> propyl <SEP> amide <SEP> (LDA) <SEP> and <SEP> esp. <SEP> -5 <SEP> to <SEP> 5 <SEP> inert <SEP> diethylether, <SEP> 1,2 <SEP> NaH <SEP> (latter <SEP> for <SEP> generation <SEP> 2. <SEP> -80 <SEP> to <SEP> -20 <SEP> dimethoxy <SEP> ethane, <tb> <SEP> of <SEP> mono-anion <SEP> only). <SEP> Pref. <SEP> esp. <SEP> -50 <SEP> to <SEP> -20 <SEP> 1,2-diethoxy <tb> <SEP> LDA <SEP> (generated <SEP> in <SEP> situ <SEP> pref. <SEP> -40 <SEP> to <SEP> -30 <SEP> ethane <tb> <SEP> cf. <SEP> Examples) <SEP> Preferred <SEP> THF <tb> # <SEP> 1. <SEP> XI <SEP> + <SEP> strong <SEP> base <SEP> 1. <SEP> Strong <SEP> base <SEP> e.g. <SEP> LDA <SEP> -80 <SEP> to <SEP> -40 <SEP> inert <SEP> as <SEP> # <tb> <SEP> 2. <SEP> add <SEP> IV <SEP> 2. <SEP> Mol <SEP> ratio <SEP> XI <SEP> to <SEP> IV <tb> <SEP> esp. <SEP> 3:1 <tb> # <SEP> Esterification <SEP> base <SEP> e.g. <SEP> pyridine, <SEP> 20 <SEP> to <SEP> 50 <SEP> excess <SEP> pyridine <tb> <SEP> triethylamine <tb> # <SEP> 1. <SEP> XVI <SEP> + <SEP> strong <SEP> 1. <SEP> Strong <SEP> base <SEP> e.g. <SEP> LDA <SEP> 1. <SEP> -80 <SEP> to <SEP> 0 <tb> <SEP> base <SEP> 2. <SEP> MOl <SEP> ratio <SEP> XVI <SEP> to <SEP> XV <SEP> 2. <SEP> -80 <SEP> to <SEP> -40 <SEP> inert <SEP> as <SEP> # <tb> <SEP> 2. <SEP> add <SEP> XV <SEP> esp. <SEP> 3:1 <SEP> esp. <SEP> -80 <SEP> to <SEP> -70 <SEP> pref. <SEP> THF <tb> # <SEP> Halogenation <SEP> XXIV <SEP> or <SEP> XXV <SEP> pref. <SEP> in <SEP> 50 <SEP> to <SEP> reflux <SEP> Anhydrous <SEP> hydro <SEP> excess <SEP> pref. <SEP> < <SEP> 150 <SEP> carbon <SEP> e.g. <SEP> benzene <tb> <SEP> toluene, <SEP> xylene <SEP> of <tb> <SEP> mixture <SEP> thereof <tb> <SEP> 20 <SEP> to <SEP> 50 <SEP> Anhydrous <SEP> e.g. <SEP> halo <tb> # <SEP> Amidation <SEP> XXVII <SEP> pref. <SEP> in <SEP> excess <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> carbon <SEP> esp. <SEP> CH2CH2 <tb> # <SEP> Cyclisation <SEP> XXIV <SEP> pref. <SEP> SOCl2 <SEP> in <SEP> 0 <SEP> to <SEP> 75 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> net <SEP> or <SEP> more <tb> <SEP> excess <SEP> uusally <SEP> as <SEP> # <SEP> or <tb> <SEP> CH2Cl2, <SEP> CHCl3 <tb> <SEP> or <SEP> CCl4 <SEP> esp. <SEP> CH2Cl2 <tb> EMI27.1 <SEP> Special <SEP> conditions/ <SEP> Temperatures <SEP> Atmosphere <SEP> Solvents <tb> Reaction <SEP> Tyep/Steps <SEP> Reagents <tb> # <SEP> Liberation <SEP> as <SEP> hydroxide <SEP> e.g.NaOH, <SEP> KOH <SEP> 0 <SEP> to <SEP> 40 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> H2O <SEP> or <SEP> H2O <SEP> + <SEP> e.g. <tb> <SEP> pref. <SEP> in <SEP> excess. <SEP> Can <SEP> be <SEP> CH3OH <SEP> or <SEP> C2H5OH <tb> <SEP> run <SEP> directly <SEP> from <SEP> crude <tb> <SEP> hydrohalide <SEP> of <SEP> # <tb> # <SEP> Grignard <SEP> 10 <SEP> to <SEP> reflux <SEP> esp. <SEP> < <SEP> 75 <SEP> inert <SEP> as <SEP> # <SEP> pref. <SEP> THF <tb> <SEP> pref. <SEP> 20 <SEP> to <SEP> 50 <tb> # <SEP> N-methylation <SEP> CH3I <SEP> pref. <SEP> in <SEP> large <SEP> 20 <SEP> to <SEP> reflux <SEP> esp. <SEP> < <SEP> 100 <SEP> Anhydrous <SEP> polar <SEP> e.g <tb> <SEP> excess. <SEP> pref. <SEP> 55 <SEP> to <SEP> 90 <SEP> THF, <SEP> 1,2-dimethoxy <SEP> ethane, <SEP> 1,2-dieth <SEP> oxyethane, <SEP> DMA, <SEP> DEA <tb> <SEP> pref, <SEP> nitromethane <tb> # <SEP> Ring <SEP> cleavage <SEP> 1) <SEP> NaBH4 <SEP> (esp. <SEP> 1-1.1 <SEP> mole), <SEP> 1) <SEP> -40 <SEP> to <SEP> 10 C <SEP> 1) <SEP> Anhydrous <SEP> alkanol <tb> <SEP> 1. <SEP> Mild <SEP> reducing <SEP> LiBH4 <SEP> (#1.8-2.1 <SEP> mole), <SEP> esp. <SEP> 0 <SEP> to <SEP> 10 <SEP> (NaBH4) <SEP> e.g. <SEP> abs. <SEP> C2H5OH <SEP> + <tb> <SEP> agent <SEP> 2) <SEP> dil. <SEP> aq. <SEP> acid <SEP> e.g. <SEP> -40 <SEP> to <SEP> -20 <SEP> (LiBH4) <SEP> optionally <SEP> ether <tb> <SEP> 2. <SEP> H# <SEP> 2N <SEP> HCl <SEP> pref. <SEP> in <SEP> large <SEP> 2) <SEP> 0 <SEP> to <SEP> 100 <SEP> e.g. <SEP> THF <tb> <SEP> excess <SEP> esp. <SEP> 20 <SEP> to <SEP> 100 <SEP> 2) <SEP> e.g. <SEP> as <SEP> @) <SEP> or <SEP> just <tb> <SEP> @@@@@@@@@@@@ <tb> # <SEP> Wittig <SEP> XXXIVA <SEP> pref. <SEP> generated <SEP> 2) <SEP> -80 <SEP> to <SEP> -30 <tb> <SEP> form <SEP> 3-methoxypropen-2-yl- <SEP> esp. <SEP> -60 <SEP> to <SEP> -40 <SEP> inert <SEP> as <SEP> # <SEP> pref. <SEP> THF <tb> <SEP> tri-phenylphosphonium <SEP> with <SEP> warmint <SEP> to <SEP> 20 <SEP> to <SEP> 30 <tb> <SEP> bromide <SEP> + <SEP> e.g. <SEP> nBuLi <tb> # <SEP> ether-cleavage <SEP> dil. <SEP> acid <SEP> e.g. <SEP> 1N <SEP> HCl <SEP> reflux <SEP> as <SEP> # <tb> <SEP> H# <SEP> in <SEP> excess <SEP> on <SEP> crude <tb> <SEP> solution <SEP> from <SEP> # <tb> EMI28.1 <SEP> Special <SEP> conditions/ <SEP> Temperatures <SEP> Atmosphere <SEP> Solvents <tb> Reaction <SEP> Tyep/Steps <SEP> Reagents <tb> <SEP> # <SEP> Hydrogenation <SEP> excess <SEP> H2 <SEP> under <SEP> pressure <SEP> + <tb> <SEP> # <SEP> Pd/C <SEP> (pref. <SEP> 5%) <SEP> + <SEP> FeCl2.4H2O <SEP> 20 <SEP> to <SEP> 30 C <SEP> esp. <SEP> 25 <SEP> 1. <SEP> alkanol <SEP> e.g. <tb> <SEP> Termination <SEP> after <SEP> 1 <SEP> mole <SEP> CH3OH <tb> <SEP> H2 <SEP> taken <SEP> up <tb> <SEP> # <SEP> 1. <SEP> cis-1-Li-2- <SEP> 1) <SEP> pref. <SEP> isolate <SEP> prior <SEP> to <SEP> 1) <SEP> -80 <SEP> to <SEP> -40 <SEP> esp. <SEP> -80 <SEP> to <SEP> -70 <SEP> inert <SEP> anhydrous <SEP> THF <tb> <SEP> ethoxyethylene* <SEP> 2) <SEP> 2) <SEP> 20 <SEP> to <SEP> 40 <SEP> esp. <SEP> 20 -30 <tb> <SEP> 2) <SEP> pTsOH <SEP> 2) <SEP> pTsOH <SEP> in <SEP> catalytic <SEP> 2. <SEP> H2O <SEP> + <SEP> THF <tb> <SEP> *prepared <SEP> e.g. <SEP> as <SEP> amounts. <tb> <SEP> described <SEP> in <SEP> the <tb> <SEP> examples. <tb> <SEP> 1. <SEP> trans-2-methoxy <SEP> 1) <SEP> 1) <SEP> -80 <SEP> to <SEP> 25 <SEP> (esp. <SEP> start <SEP> -78 <SEP> 1. <SEP> Anydrous <SEP> e.g. <tb> <SEP> cyclopropyl <SEP> 2. <SEP> tertiaryamine <SEP> e.g. <SEP> and <SEP> warm <SEP> to <SEP> 25 ) <SEP> inert <SEP> THF, <SEP> 1,2-dimeth <SEP> # <SEP> lithium <SEP> N(C2H5)3 <SEP> 2) <SEP> -60 <SEP> to <SEP> -20 <SEP> esp. <SEP> -40 <SEP> oxyethane, <SEP> 1,2 <SEP> 2. <SEP> Methanesulfonyl- <SEP> 3. <SEP> e.g. <SEP> ammonium <SEP> hydrogen <SEP> 3) <SEP> -50 <SEP> to <SEP> -30 <SEP> esp. <SEP> -40 <SEP> diethoxyethane <tb> <SEP> chloride <SEP> oxalate <SEP> + <SEP> oxalic <SEP> acid <SEP> or <SEP> pref. <SEP> diethyl <SEP> 3. <SEP> Hydrolysis <SEP> (pref. <SEP> 2 <SEP> moles <SEP> of <SEP> each) <SEP> ether <tb> <SEP> 2. <SEP> Anhydrous <SEP> e.g. <tb> <SEP> halocarbon <tb> <SEP> e.g. <SEP> CH2Cl2 <tb> <SEP> 3. <SEP> e.g. <SEP> excess <SEP> ace <SEP> tone <SEP> and <SEP> water <tb> <SEP> # <SEP> Hydrogenation <SEP> excess <SEP> H2 <SEP> under <SEP> pressure <SEP> 20 -30 <SEP> Anhydrous <tb> <SEP> + <SEP> Pd/C <SEP> (pref: <SEP> 5%) <SEP> l. <SEP> alkanol <SEP> e.g. <tb> <SEP> Termination <SEP> as <SEP> V <SEP> ethanol <tb> EMI29.1 <SEP> Special <SEP> conditions/ <SEP> Temperatures <SEP> Atmosphere <SEP> Solvents <tb> @eaction <SEP> Tyep/Steps <SEP> Reagents <tb> ## <SEP> 2-Li-2-trimethyl- <SEP> *prepared <SEP> from <SEP> 2-trimethyl <SEP> silyl-1,3-dithiane* <SEP> silyl-1,3-dithiane <SEP> and <SEP> -10 <SEP> to <SEP> 30 <SEP> inert <SEP> as <SEP> # <SEP> esp. <SEP> THF <tb> <SEP> n-BuLi/n-hexane <tb> ## <SEP> anhydrous <SEP> CF3COOH <SEP> + <SEP> 0 <SEP> to <SEP> 50 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> as <SEP> # <tb> <SEP> (C2H5)3SiH <tb> ## <SEP> N-chlorosuccinimide <SEP> of <SEP> 0 <SEP> to <SEP> 50 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> H2O <SEP> + <SEP> acetonitrile <tb> <SEP> (NBS) <SEP> or <SEP> pref. <SEP> N-bromo <SEP> succinimide <SEP> (NCS) <SEP> in <tb> <SEP> excess <tb> ## <SEP> Hydrogenation <SEP> excess <SEP> H2 <SEP> under <SEP> pressure <SEP> 20 <SEP> to <SEP> 30 <SEP> glacial <SEP> CH3COOH <tb> <SEP> + <SEP> PtO2 <SEP> until <SEP> 3 <SEP> moles <tb> <SEP> taken <SEP> up <tb> ## <SEP> Reduction <SEP> a) <SEP> NaBH4 <SEP> (type <SEP> XXXIV) <SEP> a) <SEP> 0 <SEP> to <SEP> 30 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> a) <SEP> l. <SEP> alkanol <SEP> e.g. <tb> <SEP> pref. <SEP> 2-4 <SEP> moles; <SEP> inert <SEP> CH3OH, <SEP> C2H5OH <tb> <SEP> b) <SEP> LiAlH4; <SEP> DIBAH <SEP> (alkoxy- <SEP> b) <SEP> -80 <SEP> to <SEP> reflux <SEP> pref. <SEP> < 70 <SEP> b) <SEP> as <SEP> # <SEP> pref. <SEP> THF <tb> <SEP> carbonyl <SEP> type) <SEP> at <SEP> esp. <SEP> -80 <SEP> to <SEP> 25 <tb> <SEP> least <SEP> 2 <SEP> equivalents <tb> <SEP> phosphorous <SEP> trihalide, <SEP> diethylether <SEP> or <SEP> THF <tb> ## <SEP> Halogenation <SEP> thionyl <SEP> halide <SEP> (halide <SEP> = <SEP> 20 <SEP> to <SEP> 35 <SEP> (for <SEP> PY3) <SEP> or <SEP> halo <SEP> Y) <SEP> e.g. <SEP> PCl3 <SEP> or <SEP> PBr3 <SEP> or <SEP> carbon <SEP> e.g. <SEP> CH2Cl2 <tb> <SEP> SOCl2 <SEP> or <SEP> SOBr2 <SEP> (for <SEP> SOY2) <tb> EMI30.1 <SEP> Special <SEP> conditions/ <SEP> Temperatures <SEP> Atmosphere <SEP> Solvents <tb> Reaction <SEP> Tyep/Steps <SEP> Reagents <tb> ## <SEP> Halogenation <SEP> triphenylphosphine <SEP> +CY4 <SEP> -10 <SEP> to <SEP> reflux <SEP> pref. <SEP> < <SEP> 120 <SEP> neat, <SEP> excess <SEP> CY4, <tb> <SEP> (e.g. <SEP> CCl4 <SEP> or <SEP> CBr4) <SEP> diethylether, <tb> <SEP> THF, <SEP> benzene, <SEP> toluene <tb> ## <SEP> triphenylphosphine <SEP> 60 <SEP> to <SEP> reflux <SEP> pref. <SEP> < <SEP> 150 <SEP> inert <SEP> as <SEP> # <tb> ## <SEP> Wittig <SEP> 1. <SEP> e.g. <SEP> NaH, <SEP> nBuLi <SEP> (esp. <SEP> 1. <SEP> -10 <SEP> to <SEP> 5 <SEP> inert <SEP> e.g. <SEP> THF, <SEP> benzene, <tb> <SEP> 1. <SEP> strong <SEP> base <SEP> nBuLi) <SEP> 2. <SEP> -60 <SEP> to <SEP> 80 <SEP> esp. <SEP> -55 <SEP> to <SEP> 25 <SEP> toluene <tb> <SEP> 2. <SEP> LV <SEP> (pref. <SEP> -55 <SEP> to <SEP> -50 <SEP> rising <tb> <SEP> to <SEP> 20 <SEP> to <SEP> 25 ) <tb> ## <SEP> Hydrolysis <SEP> e.g. <SEP> 10% <SEP> HCl <SEP> in <SEP> THF <SEP> or <SEP> 10 <SEP> to <SEP> 100 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> e.g. <SEP> THF <SEP> + <SEP> H2O <tb> <SEP> pref. <SEP> CH3COOH, <SEP> H2O, <SEP> THF <SEP> (HCl); <SEP> 60 <SEP> to <SEP> 65 <SEP> (CH3COOH) <tb> <SEP> (e.g. <SEP> 3:2:4) <tb> ## <SEP> oxidation <SEP> a) <SEP> mild <SEP> conditions <SEP> e.g. <SEP> a) <SEP> 10 <SEP> to <SEP> 80 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> halocarbon <SEP> e.g. <tb> <SEP> pyridinium <SEP> chloro- <SEP> b) <SEP> -60 <SEP> to <SEP> -40 <SEP> esp. <SEP> -50 <SEP> CH2Cl2 <tb> <SEP> chromate <SEP> pref. <SEP> in <tb> <SEP> excess, <SEP> or <tb> <SEP> b) <SEP> Swern's <SEP> oxidation <tb> <SEP> oxalylchloride, <SEP> DMSO, <tb> <SEP> triethylamine <tb> ## <SEP> pref. <SEP> hydroxide <SEP> is <SEP> NaOH <SEP> 0 -30 <SEP> (start <SEP> 0 <SEP> to <SEP> 10 <SEP> rising <SEP> water <SEP> plus <tb> <SEP> to <SEP> 20 -30 ) <SEP> alkanol <SEP> e.g. <tb> <SEP> ethanol <tb> EMI31.1 <SEP> Special <SEP> conditions/ <SEP> Temperatures <SEP> Atmosphere <SEP> Solvents <tb> @eaction <SEP> Tyep/Steps <SEP> Reagents <tb> <SEP> ## <SEP> Two <SEP> step <SEP> carboxyla- <SEP> 1. <SEP> Strong <SEP> base <SEP> e.g. <SEP> n.BuLi <SEP> 1. <SEP> 0 -25 <SEP> (start <SEP> 0 <SEP> to <SEP> 5 <SEP> rising <SEP> as <SEP> # <tb> <SEP> tion <SEP> 2. <SEP> CO2 <SEP> pref. <SEP> in <SEP> excess <SEP> to <SEP> 20 -25 ) <SEP> pref. <SEP> diethylether <tb> <SEP> 2. <SEP> 10 -25 , <SEP> pref. <SEP> 20 -25 <tb> <SEP> ## <tb> <SEP> to <SEP> as <SEP> # <SEP> to <SEP> # <SEP> as <SEP> # <SEP> to <SEP> # <SEP> as <SEP> # <SEP> to <SEP> # <SEP> as <SEP> # <SEP> to <SEP> # <tb> <SEP> ## <tb> <SEP> ## <SEP> Grignard <SEP> 10 <SEP> to <SEP> 40 <SEP> esp. <SEP> 20 <SEP> to <SEP> 30 <SEP> (low <tb> <SEP> temp. <SEP> maximises <SEP> selective <SEP> dis- <SEP> inert <SEP> as <SEP> # <tb> <SEP> placement <SEP> of <SEP> OCH3 <SEP> ortho <SEP> to <SEP> Ro <tb> <SEP> pref. <SEP> when <SEP> Pref. <SEP> 6-12 <SEP> moles <SEP> esp. <SEP> 6 <SEP> pref. <SEP> anhydrous <tb> <SEP> ## <SEP> Grignard <SEP> R13 <SEP> is <SEP> moles <SEP> of <SEP> CXXIII <SEP> per <SEP> mole <SEP> 60 <SEP> to <SEP> 90 <SEP> pref. <SEP> 70-80 <SEP> inert <SEP> THF <SEP> + <SEP> toluene <tb> <SEP> primary <SEP> or <SEP> or <SEP> CXXII <tb> <SEP> secondary <tb> <SEP> pref. <SEP> large <SEP> molar <SEP> excess <tb> <SEP> ## <SEP> Alkylation <SEP> of <SEP> CXXIIIA, <SEP> esp. <SEP> 4.4 <SEP> moles <SEP> -80 <SEP> TO <SEP> -20 <SEP> pref. <SEP> -50 <SEP> to <SEP> -40 <SEP> inert <SEP> as <SEP> # <SEP> esp. <SEP> THF <tb> <SEP> Lpref. <SEP> when <SEP> R13 <SEP> is <SEP> (1.1 <SEP> at <SEP> beginning, <SEP> 2.2 <tb> <SEP> tertiary) <SEP> after <SEP> 3 <SEP> hrs., <SEP> 1.1 <SEP> after <tb> <SEP> further <SEP> 2 <SEP> hrs.) <tb> <SEP> ## <SEP> Two <SEP> step <SEP> methyla- <SEP> 1. <SEP> strong <SEP> base <SEP> e.g. <SEP> n-BuLi <SEP> 1. <SEP> 0 -25 <SEP> pref. <SEP> 20 -25 <SEP> inert <SEP> 1. <SEP> as <SEP> A <SEP> esp. <tb> <SEP> tion <SEP> 2. <SEP> CH3I <SEP> 2. <SEP> 0 -30 <SEP> pref. <SEP> " <SEP> diethylether <tb> <SEP> commence <SEP> 0 <SEP> rise <SEP> to <SEP> 20 -25 <SEP> 2. <SEP> " <tb> EMI32.1 <SEP> Special <SEP> conditions/ <SEP> Temperatures <SEP> Atmosphere <SEP> Solvents <tb> Reaction <SEP> Tyep/Steps <SEP> Reagents <SEP> 1. <SEP> -10 <SEP> to <SEP> 0 <SEP> pref. <SEP> -50 <tb> ## <SEP> as <SEP> ## <SEP> as <SEP> ## <SEP> 2. <SEP> as <SEP> ## <SEP> as <SEP> ## <SEP> as <SEP> ## <tb> ##-## <SEP> see <SEP> examples <tb> <SEP> ## <tb> CI is the commercially available compound tri-o-acetyl-D-glucal. The preferred reactions conditions for Reactions AB-AI are: AB: (1) sodium, methanol, 20 C, 15 minutes; (2) mercuric acetate, 25 C. AC: sodium chloride, sodium borohydride, methanol + isopropanol, 20'C. AD: triphenylmethyl chloride, pyridine, 35 C. AE: (1) sodium hydride, tetrahydrofuran, 20 C, (2) 1-(2',4',6'-triisopropylbenzenesulfonyl)imidazole, -305rising to +20 C. AF: lithium aluminium hydride, methyl t-butyl ether, -lO-C. AG: t-butyldiphenylchlorosilane, imidazole, ,N,dimethyl- formami de, 20'C, AM: 70h aqueous trifluoroacetic acid, methylene chloride, -80 to -50iC especially -55 C rising over 1 hour to -10 to +10- -10 to +10 and keeping at latter for 3-5 hours Epimeri sation can be minimized by employing low temperatures and/or short times and terminating the reaction before completion. AI: pyridinium chlorochromate or especially chromium trioxide (e.g. as Collins oxidation) in molar excess (e.g. 8 mole per mole of CVIII)/pyridine, pyridine, methylene chloride, 20 -25 C. AJ: oxidation cf. AI. AK: reduction cf. a) and # above especially NaBH4. Resulting compounds may be conventionally separated (e.g. HPLC or column chromatography) or directly further reacted. The compounds of formulae Y, XI, XIII, XIV, XVI, XX, XXIII- XXV, XXVII, XXXI, XXXIVA, XLI, CI, CXV, CXXIII, CXXIIIA and CXXVIII and the reagents not designated by a Roman numeral are known or, if unknown, may be synthesized by processes analogous to those described in the literature for similar known compounds. As for the compound of formula LV, one isomer is disclosed in Yang et al., Tetrahedron Letters 23, 4305-4308 (1982) and the synthesis of the other isomers is disclosed in Reaction Scheme IV. The isomer of Yang et al. and the isomer disclosed in Reaction Scheme IY yield lactones having the 4R,6S configuration. Lactones having the 4S,6S configuration may be obtained from the other isomer whose synthesis is disclosed in Reaction Scheme IV. The availability of these intermediates enables synthesis of optically pure end products. Reaction products both intermediale and final can be isolated and purified in conventional mannr whereby intermediates can where appropriately be employed directly in a subsequent reaction Mixtures of stereoisomers (cis, trans and optical) may be separated by conventional means at whatever stage of synthesis is appropriate. Such methods include re-crystalisation, chromatography, formation of esters with optimally pure acids and alcohols or of amides and salts (cf also Sommer et al. J.A.C. S. 80, 3271 (1958)) with subsequent reconversion under retention of optical purity. For example diastereoisomeric (-)-a-naphthyl- phenylmethylsilyl derivatives of a lactone type end product of formula I may be separated by conventional means. Salts may be prepared in conventional manner from free acids, lactones and esters and vice-versa. Whilst all salts are covered by the invention pharmaceutically acceptable salts especially sodium, potassium and ammonium particularly sodium salts are preferred. The various forms of the compounds of formula I are by virtue of their interconvertability useful as intermediates in addition to the use set out below. Also within the scope of this invention are the intermediates of formulae YI, XII, XV, XVII, XXVIII-XXX, XXXII, XXXIII, XXXY-XL, XLII-L, LII-LIV, LVI-LVIII, CXIX-CXXII, CXXIY-CXXVII, CXXXI and CXXXII. The preferenCeS for each variable are the same as those set forth for the compounds of formula I, With the preferred groups of such compounds including those that correspond t9 Groups (i)-(xiii), (xxi)-(XXXiii) and (xli-xcii) (for formulae VI, XII, XV, XVII, XXVIII XXX, XXXII, XXXIII, XXXV-XL, XLII-L, LII-LIV, CXIX-CXXII and CXXIV-CXXVII) and Groups (xiv)-(xx), (xxxiv)-(xl) and (xciii)-(cxx) (for formula LVI-LVIII), to the extent consistent therewith, and the corresponding groups for the compounds of Groups IAa2, IAb2, IBa2, IBb2, IAa3, IAb3, IBa3 and IBb3. The compounds of formula I possess pharmacological activity in particular they are inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase and as a consequence inhibitors of cholesterol biosynthesis as demonstrated in the following three tests. Test A: In vitro Microsomal Assay of HMG-CoA Reductase Inhibition: 200 ul. aliquo,ts (1.08-1.50 mg./ml.) of rat liver microsomal suspensions, freshly prepard from male,5pargue-Dawley rats (150-225 9. body weight), in Buffer A with 10 mmol. dithiothreitol are incubated with 10 ul. test substance dissolved in dimethylacetamide and assayed for HMG-CoA reductase activity as described by Ackerman et al., J. Lipid Res. 18, 408-413 (1977). In the assay the microsomes are the source of the HMG-CoA reductase enzyme which catalyses the reduction of HMG-CoA to mevalonate. The assay employs a chloroform extraction to separate the product, [14C]mevalonolactone, formed by the HMG-CoA reductase reaction from the substrate, [14C]HMG-CoA. [ H]mevalono-lactone is added as an internal reference. Inhibition of HMG-CoA reductase is calculated from the decrease in specific activity [14C/ H]mevalonate) of test groups compared to controls. Test B: In vitro Cell Culture Cholesterol Biosynthesis Screen: The cell culture is prepared as follows: Stock monolayer cultures of the Fu5AH rat hepatoma cell line (originally obtained from G. Rothblat; see Rothblat, Lipids 9, 526-535 (1974) are routinely maintained in Eagle's Minimum Essential Medium (EMEM) supplemented with 10% fetal bovine serum (FBS) in 75 cmê tissue culture flasks. For these studies, when the cultures reach confluence, they are removed by mild enzymatic treatment with 0.25% trypsin in Hanks' balanced salt solution (without c-alcium and magnesium). After centrifugation of the cell suspension and aspiration of the enzymatic solution, a cell pellet is resuspended in an appropriate volume of media for seeding into 60 mm. tissue culture dishes. The cultures are incubated at 37 C in an atmosphere of high humidity and 5X carbon dioxide. When the cultures are confluent (approximately 5 d-ays), they are ready for use. The culture media is aspirated from the dishes and replaced with 3 ml of EMEM suplemented with S mg/ml of dilipidized serum protein (DLSP) prepared by the method of Rothblat et al., In vitro 12, 554-557 (1976). Replacement f the FBS with DLSP has been shown to stimulate the incorporation of [14C]acetate into sterol by removing the exogenous sterol supplied by the FBS, thereby requiring the cells to synthesized sterol. Enthanced 3-hydroxy-3-methylglutaryl CoenzyTe A reXctase (HMG-CoA reductase) activity is measurable in the cells in response to the lack of exogenous sterol . Following aproximately 24 hours incubation at 37 C in the OLSP supplemented medial the assay is initiated by the addition of 3 Ci of [14C]acetate and the test substances solubilized in dimethylsulf3xide (DMSO) or distilled water. Solvent controls and compactin-treated controls are always prepared. Triplicate 60mm. tissue culture dishes are run for each group. After 3 hours incubation at 37 C, the cultures are examined microscopically using an inverted phase contrast microscope. Notations are made of any morphological changes which may have occurred in the cultures. The media is aspirated and the cell layer is gently washed twice with 0.9% sodium chloride solution (saline). The cell layer is then harvested in 3 ml. of 0.9% saline by gentle scraping with a rubber policeman and transferred to a clean glass tube with Teflon lined cap. The dishes are rinsed with 3 ml. of 0.9% saline and rescraped, and the cell-s are combined with the first harvest. The tubes are ce1Ttrifuged at 1500 r.p.m. for 10 minutes in an IEC PR-J centrifug nd the supernatant is asperated. The cells are then extracted as follows: One ml. of 100% ethanol is added to the cell pellet followed by sonication for 10 seconds with a "LO" setting of 50 on a Bronwell Biosonik IV. One hundred l. are taken for protein determination. One ml. of 15% potassium hydroxide (KOH) is addled, and t he samples are thoroughly vortexed. Saponification is accomplished by heating the ethanol-KOH treated sampl-es at 60 C for 60 minutes in a water bath. Following dilution of-the samples with 2ml. of distilled water, they are extracted three times with 7 ml. of petroleum ether. The petroleum,ether extracts are then washed three times with 2 ml. of distilled water and finally taken to dryness under a stream of nitrogen. The obtained samplessre--then analyzed by thin layer chromatography (TLC) as follows: Residues from the petroleum ether extraction are taken up in a small volume of hexane and spotted on silica gel 60 TLC plates (E. Merck). Developllent of the plates is carried out in a 150 parts by volume hexane: 50 parts by volume diethyl etirer:-5 parts by volume galcial acetic acid solvent system using a three phase development procedure. Visualization is accomplished in an iodine vapor chamber. The plates are divided into five sections such that each section contains the molecules havin9-the following approximate Rf values: section 1- 0-0.4, section 2- 0.4-0.55, section 30.55-0.7, section 4- 0.7-0.9 and section 5- 0.9-1.0. Section 2 contains the non-saponifiable sterols. The five sections of the TLC plates are scraped into scintillation vials. Blanks are also prepared from scrapings of chromatographed non-labelled standards. ACS# scintillation cocktail is added, and the radioactivity is determined in a 1.quid scintillation spectrometer. [14C]hexadecane standards are used to determine counting efficiencies. The total protein content of the samples is determined employing the Bio-Rad Prtein Assay System. The results are reported as disintegrations per minute per mg protein (d.p.m./mg protein) for each-of the live TLC sections. Mean d.p.m./mg protein + standard error of the mean are compared for percentage change (%#) and statistical significance with solvent control means. TLC section 2 data is taken as a measure of HMG-CoA reductase activity inhibition. Test C: In Yivo Cholesterol Biosynthesis Inhibition Tests: In vivo studies utilize male llistar Royal Hart rats weighing 150+20 9 which have been kept for 7-10 days on an altered light cycle (6:30 a.m. - 6:30 p.m. dark) housed two per cage and fed powdered Purina Rat Chow and water ad 7ibitum. Three hours before the diurnal maximum of cholesterol synthesis at mid-dark, the rats are administered the test substances dissolved or as a suspension in 0.5% carboxymethylcellulose in a volume of 1 ml/100 g body weight. Controls receive vehicle alone. One hour after receiving the test substance, tne rats-are injected intraperitoneally with about 25 Ci/100 @ g body weight of sodium [1-14C]acetate 1-3 mCi/mmol. Two hours after mid-dark, blood samples are obtained under sodium hexoL rbitol anesthesia and the serum separated by centrifugation. Serum samples are saponified and neutralized, and the 3ss-hydroxy sterols are precipiated with digitonin basically as described by Sperry et al., J. Biol. Chew. 187, 97 (1950). The [14C]digitondes are then counted by liquid scintillation spectrometry. After correcting for efficiencies, the results are calculated in nci (nanocuries) of sterol formed per 100 ml of serum. Inhibition of sterol synthesis is calculated from the reduction in the nci of sterols formed from test groups compared to controls. The compounds are thus indicated for use as hypolipoproteinemic and anti-ath. osclerotic agents. An indicated suitable daily dosage for use in the treatment of pyperlipoproteinemia and athersclerosis is from about 4 to 2000 mg suitably 4-200 e.g. 10 to 100 for the more active compounds suitably administered in divided dosages of 1 to 1000 mg suitably 2.5 to 50 mg two to faur times daily or in retard form. They may be administered in free acid form or in the form of a physiologically-hydrolysable and -acceptable ester or a lactone thereof or in pharmaceutically acceptable salt form. The invention therefore also concernS a method of treating hyperliproproteinemia or atherosclerosis by administration of a compound of formula I in free acid form or in the form of a physiolo nicallv-hvdro7vsable and -acceDtable ester or a lactone thereof or in EMI39.1 pharmaceuticals e.g. as hypolipoproteinemic and anti-atherosclerotic agents. The compounds may be administered alone, or in admixture with a pharmaceutically acceptable diluent or carrier, and, optionally other excipientS, and administered orally in such fortrs as tablets, elixirs, capsules or suspensions or parenterally in such forms as injectable solutions or suspensions. The preferred pharmaceuMçal compositions from the standpoint of ease of preparation and administration are solid compositions, particularly tablets and hard-filled or liquid filled capsules. Such compositions also form part of the invention. The following examples, in which all temperatures are in C i l lustrate the invention. Example 1 Ethyl erythro-(E)-3,5-dihydroxy-7-(2'-[4"-flu hept-6-enoate (compound no. 1) Step 1 : 2-Methoxy-l-naphthoyl chloride (Reaction M; compound XXVIa) 6.06 9 of 2-methoxy-1-naphthoic acid and 7.62 ml of oxalyl chloride are added to 50 ml of anhydrous toluene, and the obtained reaction mixture is refluxed for 2 hours and evaporated to dryness at reduced pressure to obtain the crude product. step 2 : 2-Methoxy-l-naphthoic acid N-l,l-dimethyl-2-hydroxyethylamide (Reaction N; compound XXVIIIa) 50 ml of methylene chloride (dried over molecular sieves) and 5.4 9 of 2-amino-2-methyl-1-propanol are added to the crude 2-methoxy-1- naphthoyl chloride produced in step 1 while cooling in an ice bath. The reaction mixture is stirred at room temperature overnight, 50 ml of methylene chloride is added, and the reaction mixture is quenched With water. The methylene chloride phase is separated, washed twice with 10% aqueous sodium bicarbonate, dried over anhydrous sodium sulfate and evaporated at reduced pressure to near dryness. Diethyl ether is added to the residue, and the precipitate is dried under vacuum to obtain the colourless product, m.p. 160 -163 C. When this reaction is scaled up, the yield is improved if one adds a solution of 2-methoxy-1-naphthoyl chloride in methylene chloride to a solution of 2-amino-2-methyl-1-propanol in methylene chloride stirred at 0 -5 C. step 3: 4, 4,4-Dimethyl-2-(2'-methoxynaphth-1'-yl)-2-oxazoline.hydrochloride (Reaction O; compound XXIXa) 4.8 ml of thionyl chloride is slowly added to 6.0 9 of Compound XXVIIIa, the obtained suspension is stirred under nitrogen at room temperature for 4 hours, 10 ml of methylene chloride dried over molecular sieves is added, and the reaction mixture is stirred overnight under nitrogen. 50 ml of diethyl ether is added, and the precipitated solid is washed with diethyl ether and dried under vacuum to obtain the colourless product, m.p. 168 -171 C. step 4 : 4,4-Dimethyl-2-(2'-methoxynaphth-1'-yl)-2-oxazoline (Reaction P; compound XXXa) 75 ml of 20X aqueous sodium hydroxide is added to 13 9 of Compound XXIXa and the reaction mixture is extracted four times with diethyl ether, The diethyl ether extracts are combined, dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure, and the residue is triturated with diethyl ether/petroleum ether. The resulting solid is dried under vacuum to obtain the colourless product, m.p. 98 -101 C. step 5: 4 4,4-Dimethyl-2-(2'-[4"-fluorophenyl]naphth-1'-yl)-2-oxazoline (Reaction Q; compound XXXIIa) A Grignard reagent prepared from 4.2 9 of p-bromo-fluorobenzene and 0.583 9 of magnesium turnings in 20 ml of dry tetrahydrofuran (distilled over sodium) is slowly added to a solution of 5.1 9 of Compound XXXa in 30 ml of dry tetrahydrofuran stirred at room temperature under nitrogen. The reaction mixture is stirred overnight at room temperature under nitrogen and, while slightly cooling, is quenched with 20 ml of saturated ammonium chloride solution. The reaction mixture is extracted with diethyl ether, and the diethyl ether extract is dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure. The residue is triturated with diethyl ether/petroleum ether, and the precipitate is dried under vaCuum to obtain the colourless product, m.p. 115 -117 C. Step 6 : 2-(2'-[4"-Fluorophenyl]naphth-1'-yl)-3,4 iodide (Reaction R; compound XXXIIIa) 7 ml of methyl iodide is added to a solution of 4.34gof Compound XXXIIa in 30 ml of nitromethane, and the reaction mixture is stirred at 80 -90 C under nitrogen overnight. The reaction mixture is cooled to room temperature, and 200 ml of methyl ether is added; the resulting gummy precipitate solidifies on standing. The solid is washed With diethyl ether, dried under vaCUum and recrystallised from acetonitrile/ ether to obtain the yellow product, m.pt 220 -222 C. step 7: 2-(4'-Fluorophenyl )-l-naphthaldehffle (Reaction S; compound IVa) 0.936 9 of sodium borohydride is added portion-wise over a 2 minute period to a suspension of 11.36 9 of Compound XXXIIIa in 120 ml of absolute ethanol stirred at about 0 C. The reaction mixture is stirred at about 0 C under nitrogen for 2 hours, and 200 ml of 2N.hydrochloric acid is added, cooling being maintained during the addition. The reaction mixture is stirred at room temperature under nitrogen for 40 hours, concentrated at reduced pressure and extracted three-times with diethyl ether. The diethyl ether extracts are combined, washed twice with 3% aqueous sodium thiosulfate, washed once with water, dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure. The residue is dissolved in methylene chloride, and the solution is treated with charcoal, filtered and evaporated at reduced pressure to a small volume. A small amount of isopropanol is added, and the solution iS evaporated under vacuum without heating. The precipitated colourless solid is washed with cold isopropanol, washed with petroleum ether and dried under vacuum to obtain the product, m.p. 78 -80 C. step 8 : (E)-3-(2'-[4"-Fluorophenyl]naphth-1'-yl)prop-2-enal (Reaction Wj compound IVb) 3.16 ml of 1.3M n-butyllithium/n-hexane is added dropwise to a solution of 1.414 9 of cis-1-ethoxy-2-tri-n-butylstannylethylene in 40 ml of dry tetrahydrofuran (distilled over sodium) stirred at -78 C under nitrogen, stirring is maintained for 2 hours nder the same conditions, and a solution of 0.888 9 of Compound IVa in 10 ml of dry tetrahydrofuran (distilled over sodium) is added. The reaction mixture iS stirred at -78 C under nitrogen for 1.5 hours and allowed to warm to room temperature. 5 ml of saturated aqueous sodium bicarbonate is added followed by 50 ml of water. The reaction mixture is extracted twice with 50 ml portions of diethyl ether, and the diethyl ether extracts are combined, washed twice with 50 ml portions of saturated aqueoUs sodium chloride, dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure. The residue is distributed between acetonitrile and n-hexane. The acetonitrile layer is extracted twice with n-hexane and evporated to dryness at reduced pressure to obtain a dark green gum. 30 ml of 80% aqueous tetrahydrofuran and 5 mg of p-toluenesulfonic acid monohydrate are added, and the reaction mixture is stirred at room temperature for 4 hours. Water and 0.5 9 of solid sodium bicarbonate are added, and the reaction mixture is extracted with ethyl acetate. The ethyl acetate extract is dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure to obtain a yellow sticky solid. The solid is triturated with diethyl ether/petroleum ether to obtain the colourless product, m.p. 119 -122 C. Step 9 : Ethyl (E)-7-(2'-[4"-fluorophenyl]naphth-1'-yl)-5-hydroxy-3- oxohept-6-enoae (Reaction A; compound VIa) 29.1 ml of 1.7 M n-butyllithium/n-hexane is slowly added to a solution of 6.9 ml of diisopropylamine in 140 ml of dry tetrahydrofuran stirred at 0 C under nitrogen. The reaction mixture is stirred at 0 C under nitrogen for 20 minutes, 3.14 ml of ethyl acetoacetate iS slowly added, and the reaction mixture is stirred under the same conditions for 1 hour and cooled to -40 to -S C. A solution of 3.4 9 of Compound IVb in 75 ml of dry tetrahydrofuran is slowly added to the reaction mixture stirred at -40 to -30 C under nitrogen. The reaction mixture is stirred for an additional 45 minutes under the same conditions, quenched with 150 ml of saturated aqueous armonium chloride and allowed to warm to room temperature overnight. Water is added to the reaction mixture, and the reaction mixture iS extracted with ethyl acetate. The ethyl acetate extract is washed with water, dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure. The gummy residue is triturated with a small amount of diethyl ether, and the precipitated colourless solid is washed with cold 1:1 (by volume) diethyl ether/petroleum ether and dried under vacuum to obtain the product, m.p. 84 -86 C. The product is a racemate that may be resolved into its R and S components . step 10: Ethyl erythro-(E)-3,5-dihydroxy-7-(2'-[4"-fluorophenyl]naphth- l'-yl3hept-6-enoate (prowess a); compound no. 1) 6.52 ml of 1M tri-n-butylborane/tetrahydrofuran is added to a solution of 2.42 9 of Compound VIa in 200 ml of dry tetrahydrofuran stirred at room temperature, and 34 ml of air (at 25 C and 760 mm Hg) is slowly bubbled in. The reaction mixture is stirred at room temperature for 2 hours and cooled to -78 to -75 C, and 0.248 9 of sodium borohydride is added portion-wise. The reaction mixture is stirred at -78 to -75 C under nitrogen for 3 hours, and a solution of 33.8 ml of 30% aqueous hydrogen peroxide, 67.6 ml of an aqueous pho hate buffer having a pH of 7.2 (0.047M. sodium phosphate/0.024M. potassium phsophate/0.054M. sodium hydroxide) and 67.6 ml of methanol is slowly added, the aforementioned temperature being maintained during the addition. The reaction mixture is allowed to warm to room temperature overnigt)t, cater is added,and the reaction mixture is extracted three times with methylene chloride. The methylene chloride extracts are combined, dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure. Methanol is added to the residue, it is heated at 40 to 45 C for 30 seconds, and the methanol is evaporated at reduced pressure at room temperature; this procedure is repeated twice. The residue is triturated with a small amount of diethyl ether while being cooled. The precipitated colourless solid is washed with diethyl ether/petroleum ether and dried under vacuum to obtain the product, m.p. 114 -116 C. The product is a racemic mixture which mayp=:resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former is preferred. The use of a non-stereoselective reduction, a t-butylamine-borane complex in abs. C2H50H at 0 for 1 hour, affords a mixture of all four enatiomers (compound no. J2'). Example 2 : Erythro-(E)-3,5-dihydroxy-7-(2'-[4"-fluorophenyl]naphth-1'-yl)- hept-6-enoic acid and its sodium salt-Sprocess d); compound nos. 2 and 3) A mixture of 0.30 g of Compound 1, 10 ml of ethanol and 0.88 ml of 1N. aqueous sodium hydroxide is stirred at room temperature for 1.5 hours, water is added and the reaction mixture is extracted with diethyl ether. The aqueous phase, which contains racemic sodium salt can either be evaporated to dryness, m.p. 210 -220 C (decomp.) (compound 3) or acdified with 2N. hydrochloric acid, to yield a gummy precipitate which is extracted with ethyl acetate. The ethyl acetate extract is dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure to obtain the crude free acid as a sticky pale yellow foam, m.p. 43 -102 C (compound 2). The products are racemic mixtures which may be'resolved into optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which s former is preferred. Example 3 : (E)-Trans-6-(2'-[2"-(4"'-fluorophenyl)naphth-1"-yl]ethen 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one (process e); compound no. 4) A solution of 0.223 9 of Compound 2 in 40 ml of dry toluene is refluxed for 5 hours, the water formed being removed by the use of a Dean-Starke apparatus. The reaction mixture is cooled and extracted with lOX aqueous sodium bicarbonate and with water. The toluene solution is dried over anhydrous sodium sulfate and evaporated to dryness at reduced preSsure. The residue is dissolved in diethyl ether and evaporated at reduced pressure and room temperature until precipltatnon commenceS. The solution is cooled, and the precipitated pale yellow solid is washed with petroleum ether and dried under vacuum to obtain the product, m.p. 152-154 C. The product is a racemate that may be resolved by conventional means into two optically pure enantiomers, the 4R,6S and 4S,6R isomers, of which the former iS preferred. The product contains about 1% of the correwonding cis racemate, which may be separated from the trans racemate by, for example, column chromatography. The cis racemate may be resolved by conventional means into two optically pure enantiomers, the 4R,6R and 4S,6S isomers. The cis racemate results from a small amount of the threo isomer of Compound 1 formed in step 10 of Example I and not separated therefrom which iS carried through process d) (Example 2) and process e) (this example). A sample of the trans lactone free of any detectable cis lactone melted at 153 to 156 C. Example 4: Ethyl erythro-3,5-dihydroxy-7-('-[4"-fluorophenyl]-5',6',7',8'- tetrahydronaphth-l'-yl)heptanoate (compound no. 5) step 1 : Ethyl 7-(2'-[4"-fluorophenyl]-5',6',7',8'-tetrahydronaphth-1'-yl- 5-hydroxy-3-oxoheptanoate (reaction JJ; compound VIb) A solution of 406 mg ( 1mmole) of Compound VIa in 20 ml of glacial acetic acid is contacted with a large eXcess of hydrogen at an initial pressure of 50 p.s.i. at room temperature in the presence of 40 mg of platinum dioxide until 3 moles of hydrogen (7.5 p.s.i.) are taken up. The platinum dioxide is removed by filtration, and the filtrate is evaporated to dryness at reduced pressure. The residue (397 mg) is dissolved in a small amount of methylene chloride and applied to silica gel preparative thin layer chromatography plates; methylene chloride is used as the chromatography solvent. The bands containing the product are fluted with ethyl acetate. The ethyl acetate is evaporated at reduced pressure to obtain the crude product as a yellow gum. The product is a racemate that may be resolved into its R and S components. step 2: Ethyl erythro-3,5-dihydroxy-7-(2'-[4"-fluorophenyl]-5' tetrahydronaphth-1'-yl)heptanoate (procesS a); compound no. 5) Analogous to Example 1. step 10 starting from VIb. Product (compound no. 5) is obtained as a yellow gum. The product is a racemate that may be resolved into two optically pure enantiomers, the 3R,5R and 3S,5S isomers, of which the former is preferred. Example e 5: Ethyl erythro-(E)-7-(4'-chloro-2'-[4"-fluorophenyl]naphth-1'-yl- 3,5-dShydroxyhept-6-enoate (compound no. 6) step 1 : 4-Chloro-2-naphthol (reaction DA; compound no. cxxix) A solution of 406 mg (I mmole) of Compound VIa in 20 ml of glacial acetic acid is contracted with a large excess of hydrogen at an initial pressure of 50 p.s.i. at room temperature in the presence of 40 mg of platinum dioxide until 3 mmo l es of hydrogen ( 7. 5 p.s.i.) are taken up. The platinum dioxide is removed by filtration, and the filtrate is evaporated to dryness at reduced pressure. The residue (397 mg) is dissolved in a small amount of methylene chloride and applied to silica gel preparative thin layer chromatography plates; methylene chloride is used as the chromatography solvent. The bands containing the product are eluted with ethyl acetate. The ethyl acetate is evaporated at reduced pressure to obtain the crude product as a yellow gum. The product is a racemate that may be resolved into its R and S components . Step 2 : Ethyl erythro-3,5-dihydroxy-7-(2'-[4"-fluorophenyl]-5',6',7',8' tetrahydronaphth-1'-yl)heptanoate (process a); compound no. 5) Analogous to Example 1, step 10 starting from VIb. Product (compound 5) is obtained as a yellow gum. The product is a racemate that may be resolved into two optically pure enantiomerS, the 3R,5R and 3S,5S isomers, of which the former is preferred . Example 5 : Ethyl erythro-(E)-7-(4'-chloro-2'-[4"-fluorophenyl]naphth-1'- yl-3,5-dihydroxy)hept-6-enoate (compound no. 6) step 1 : 4-Chloro-2-naphthol (Reaction DA; compound CXXIX) A mixture of 90 9 (0.42 mole) of 1,4-dichloro-2-naphthol, 420 9 of stannous chloride.dShydrate and 1.5 liters of glacial acetic acid is refluxed for about 80 hours, gaseous hydrogen chloride being slowly bubbled in throughout. The reaction mixture is added to 9 liters of ice water5 the resulting mixture is stirred for 1 hour,.and the product is collected.by filtration, washed with 4 liters of water, washed with 2 liters of petro--leum-either, air dried and dried at 40 C under high vacuum for 5 hours5 m.p. 93 -95 C. step 2 : 1-Chloro-3-methoxynaphthalene (Reaction DB; compound CXXX) 23.2 9 (0.414 mole) of ground potassium hydroxide is added to a mixture of 65.4 (0.366 mole) of 4-chloro-2-naphthol and 370 ml of dimethylformamide stirred at 0 -5 C. The reaction mixture iS stirred at 0 -5 C for 3 hours, 58.8 g (0.414 mole) of methyl iodide is added over a 5 minute period, and the reaction mixture is allowed to warm to 20 to 25 C and is stirred at that temperature for 16 hours. 2 Liters of water is adÅaed, and the mixture is extracted with diethyl ether. The diethyl ether is evaporated at reduced pressure until the onset of turbidity, and petroleum-ether is added to obtain the solid product, m.p. 35 -39 C. Step 3 : 4-Chloro-2-methoxy-1-naphthaldehyde $(Reaction DC; compound CXXXI) 50 9 (0.326 mole) of phosphorus oxychloride is slowly added to a mixture of 24 9 (0.125 mole) of 1-chloro-3-methoxynaphthalene and 30 g (0.411 mole) of dimethylformamdie stirred at 20 -25 C. The reaction mixture is stirred at 80 C for 16 hours, cooled in an ice bath and made basic by the dropwise addition of 10% aqueous sodium hydroxide solution with vigorous stirring. The precipitate is collected by filtration, washed with water, washed with petroleum ether and air dried to obtain the crude product, m.p. 145 -160 C (dec.) (shrinks at 105 -145 C). An analytical sample may be obtained by (a) dissolving the crude product in ethyl acetate, (b) adding petroleum ether, (c) decanting the solution from the insoluble tar, (d) repeating (b) and (c) until no more tar results and (e) adding additional petroleum ether to obtain the pure product, m p 154 -157 C step 4: : 4-Chloro-2-methoxy-1-naphthoic acid (Reaction DE, compound XXIIIa) 18.6 9 (0.175 mole) of sodium carbonate is added to a mixture of 37.2 9 (0.169 mole) of crude 4-chloro-2-methoxy-1-naphthaldehyde, 450 ml of acetone and 92 ml of water stirred at 20 -25 C. 27.9 g (0.177 mole) of potassium permanganate is added over a 2.5 hour period with stirring at 40 -45 C. The reaction mixture is stirred at room temperature for 16 hours, 400 ml of water is added, and the reaction mixture is filtered through Celite, acidified with 2N. hydrochloric acid and extracted with ethyl acetate. The ethyl acetate extract is extracted, three times with 10% aqueous sodium carbonate solution, and the combined aqueous extracts are carefully acidified with 2N hydrochloric acid. The obtained product is washed with water and washed with petroleum ether, m.p. 199.5 -202 C. step¯5 to 14 Proceed analogously to steps 1 to 10 of Example 1 through the intermediates listed hereafter. step 5: 4-Chloro-2-methoxy-1-naphthoyl chloride (Reaction M; compound XXVIb), oil) Step 6 : 4-Chloro-2-methoxy-1-naphthoic acid N-1,1-dimethyl-2-hydroxy ethylamide (Reaction N, compound XXVIIIb), m.p. 142 to 146" step 7 and 8 : 2-(4'-Chloro-2'-methoxynaphth-1'-yl)-4,4-dimethyl-2-oxazoline and its hydrochloride salt (Reactions O and P; compound XXXb and XXIXb), m.p. 91-94 (XXXb) Step 9 : 2-(4-Chloro-2'-[4"-fluorophenyl]naphth-1'-yl)-4,4-dimethy oxazoline (Reaction Q; compound XXXIIb), m.p. 150 -152 Gringard reagent cf. Example 10.7, step 10: 2-(4 ' -Chloro-2' -[4"-fluorophenyl]naphth-1 '-yl )-3,4,4-trimethyl- 2-oxazolinium iodide (Reaction R; compound XXXIIIb), m- p . 224 -226 Step 11 : 4-Chloro-2-(4'-fluorophenyl)-1-naphthaldehyde (Reaction S; compound IVc), m. p . 137 -139 Step 12 : (E)-3-(4'-Chloro-2'-[4"-fluorophenyl]naphth-1'-yl)prop-2-enal (Reaction W, compound IVd), m.p. 143-147 step 13: Ethyl (E)-7-(4-chloro-2'-[4"-fluorophenyl]naphth-1 hydroxy-3-oxohept-6-enoate (Reaction A, compound VIc), m.p. m.p. 87 -89 Step 14 : Ethyl erthro (E)-7-(4-chloro-2'-[4"-fluorophenyl]naphth-1'-yl- 3,5-dihydroxyhept-6-enoate (process a), compound no. 6), m.p. 121-124 The principal (erythro) product is a racemate that may be resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former is preferred. The threo minor product is a racemate that may be resolved into the 3R,5R and 3S,5S isomers, of which the former is preferred. The use of a non-stereoselective reduction would afford all four stereoisomers in approximately equal amounts. The crude reaction mixture of Step 14 also contains threo isomer. Example 6 : Erythro-(E)-7-(4'-chloro-2'-[4"-fluorophenyl]naphth-1'-yl)- 3,5-dihydroxyhept-6-enoic acid and its sodium salt (process d); compounds 7 and 8 ) Analogous to Example 2 starting from compound 6, m.p. 201 -204 (dec.) for salt. Free acid as crude oil containing a small amount of threo compound. The principal (erythro) product is a racemate which may be resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former iS preferred. The minor (threo) product is also a resolvable racemate, the two enantiomers being the 3R,5R and 3S,5S isomers, of which the former iS preferred. Example 7 : (E)-Trans-6-(2'-[4"-chloro-2"-(4"'-fluorophenyl)naphth-1"-yl]- ethenyl-4-hydroxy-3,4,5,6-tetrahydro-2H (Process e); compound 9) Analogous to Example 3 starting from Compound 7, m.p. of product 131 -134 . Example 8 : (E)-Trans-6S-2'-[2"-(4"'-fluorophenyl)naphth-1"-yl]ethenyl) 4R-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one (compound no. 10) Step 1 : 2-(4'-fluorophenyl)-1-naphthalenemethanol (Reaction KK, compound LIIa) 75 g (1.94 moles) of powdered sodium borohydride is added to a mixture of 497 9 (1.988 moles) of 2-(4'-fluorophenyl)-1-naphthaldehyde and 6.6 liters of absolute ethanol stirred at 20 -25 . The reaction mixture is stirred at this temperature for 16 hours, suction filtered through I kg. Of silica gel (EM-60, 230-240 mesh ASTM) and evaporated at reduced pressure to obtain a crystalline residue. The solids are collected by filtration. washed with 100 ml of cold (0 ) methylene chloride and taken up in 1 liter of diethyl ether. The insoluble residue is removed by filtration, and the filtrate is evaporat-ed to dryness at reduced pressure. The residue is dissolved in 500 ml of methylene chloride, and the solution is cooled to 0 to obtain the product, m.p. 91-93 . step 2: 1-Chloromethyl-2-(4'-fluorophenyl)naphthalene (Reaction LL; compound LIIIa) A solution of 45 g (0.378 mole) of thionyl chloride in 500 ml of methylene chloride is added over a 20 minute period to a mixture of 237 g (0.94 mole) of 2-(4'-fluorophenyl)-1-naphthalenemethanol and 3 liters of methylene chloride stirred at 20 -25 under nitrogen, and the reaction mixture is stirred at this temperature for 16 hours. An additional 25 g (0.31 mole) of thionyl chloride is added, the reaction mixture is stirred at 20 -25 for 2 hours and cooled to 0 . 1 liter of 10% aqueous sodium bicarbonate solution iS cautiously added, the organic layer iS separated, and the aqueoUS phase Us-extracted with 500 ml of methylene chloride. The two organiC phases are ce ined, washed with 1 liter of saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered through 1 kg of SiliCA gel (EM-60, 230-400 mesh ASTM) and concentrated at reduced preSsure to obtain the crystalline product, m.p. 93-95 . step 3 : C(2-C4'-Fluorophenyl3-l-naphthalenyl )methyltriphenylphosphonium chloride (Reaction NN; compound LIVa) A mixture of 218 9 (0.81 mole) of 1-chloromethyl-2-(4'-fluorophenyl)- naphthalene, 214 9 (0.81 mole) of triphenylphosphine and 4 liters of toluene is refluxed under nitrogen for 16 hours, cooled, concentrated at reduced pressure, to about 1/3 of its original volume, filtered through 1 kg of silica gel (EM-60, 230-400 mesh ASTM) and evaporated to dryness at reduced pressure. 500 ml of anhydrous diethyl ether is added to the crystalline residue, the mixture is cooled to 0 , and the precipitate is collected by filtration, washed twice with a total -of 500 ml of anhydrous diethyl ether and vacuum dried at 70 for 5 hours to obtain the product as a colourless solid, m.p. > 250 . Step 4 : (E)-4ssR-(1',1'-Dimethylethyl-diphenylsilyl fluorophenyl)naphth-1"-yl]ethenyl)-2-metho 2H-pyran (Reaction 00, compound LVIa) 115.6 ml of 1.65M. n-butyllithium/n-hexane (0.191 mole) is added over a period of 5 minutes to a mixture of 100 9 (0.188-mol-e) of Compound LIVa in 1.5 liters of dry tetrahydrofuran stirred at -15 under nitrogen. The reaction mixture is stirred at about 0 for 1 ho-ur-and cooled to -55 , a solution of 71.5 9 (0.179 mole) of Compound LVa EMI53.1 in 600 ml of dry tetrahydrofuran is added over a period of about 20 minutes, the temperature of the reaction mixture being -55 to -50 during the addition, and the reaction mixture is allowed to slowly warm to 20 -25 over a 16 hour period, stirring under nitrogen being maintained throughout. The reaction mixture iS cooled to 0 , quenched with 1 liter of saturated aqueous ammonium chloride solution and filtered through Celite. The organic phase is separated, and the aqueous phase is extracted twice with 750 ml portions of diethyl ether. The three organic phases are combined, washed with 1 liter of saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure to obtain an oil. The oil is dissolved in 150 ml of 2:1 (by volume) methylene chloride/n-hexane and flash chromatographed on a column packed with 1 kg of silica gel (EM-60, 230-400 mesh ASTM) utilizing the same solvent as the eluant. The fractions containing the product (as determined by thin layer chromatography) are combined and evaporate to dryness at reduced pressure to obtain the product as a gummy solid, [&alpha;]D26 = +24.51 (CH2Cl2, c = 0.01). Step 5 : (E)-4ssR-(1',1'-Dimethylethyl-diphenylsilyloxy fluorophenyl)naphth-1"-yl]ethenyl)-2-hydroxy hydro-2H-pyran (Reaction PP; compound LYIIa) A mixture of 121 g (0.196 mole) of Compound LVIa and 2 liters of 3:2:4 (by volume) acetic acid/water/tetrahydrofuran is heated to 65 with stirring, stirred at 65 for 16 hours and cooled to 20 -25 , and 1.5 liter of methylene chloride is added. With stirring and cooling, the mixture is carefully washed with saturated aqueous sodium carbonate solution until slightly basic. The organic phase is separated, and the aqueous phase is extracted with 1 liter of methylene chloride. The organic phases are combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and evaporated at reduced pressure to obtain a light brown oil. The oil is dissolved in 1:1 (by volume) diethyl etherZpetroleum ether and flash chromatographed on a column packed with 1 kg of silica gel (EM-60, 230-400 mesh ASTM) utilizing the same solvent aS the eluant. The fractions containing the product and little or nothing else (as determined by thin layer chromatography) are combined and evaporated at reduced pressure t-Q obtain the product as a gummy solid, [&alpha;]D26 = +5.0 (CH2Cl2, c = 0.01). Step 6 : (E)-4ssR-(1',1'-Dimethylethyl-diphenylsilyloxy)-6&alpha; (4"'-fluorophenyl)naphth-1"-yl]ethenyl)-3,4,5,6-t pyran-2-one (Reaction QQ; compound LVIIIa) A mixture of 89 9 (0.147 mole) of Compound LVIIa, 2 liters of methylene chloride, 64 9 (0.317 mole) of pyridinium chlorochromate and 60 g of &num;3A mlecular sieves is stirred at 20 -25 under nitrogen for 16 hours and filtered through Celite and about 100 9 of neutral aluminium oxide. The Celite and aluminium oxide are washed several times with methylene chloride and the filtrate and washings are combined and evaporated at reduced pressure to obtain an oil. The oil is dissolved in 100 ml of methylene chloride and flash chromatographed on a column packed with 80Q 3 of silica gel (EM-60, 230-400 mesh ASTM) utilizing methylene chloride as the eluant. The fractions containing the product and little or nothing else (as determined by thin layer chromatography) are combined and evaporated at reduced pressure to obtain the product as an oil, [&alpha;]D25 = +12.32 (CH3OH, c = 0.0215). Step 7 : (E)-Trans-6S-(2'-[2"-(4"-fluorophenyl)naphth-1"-yl]ethenyl) 4R-hydroxy-3,4,5,6-tetrahydropyran-2H-one (process c) ; compound no. 10) 26.3 ml (0.46 mole) of glacial acetic acid is added with stirring to a mixture of 63 9 (0.105 mole) of Compound LVIIIa in 2.3 liters of dry tetrahydrofuran stirred at 20 -25 . 425 ml of 1M. tetra-n-butyl ammonium fluoride/tetrahydrofuran (0.425 mole) iS added, and the reaction mixture is stirred at 20 -25 for 2 hours. 157 9 of solid sodium bicarbonate iS added, and the reaction mixture is stirred for 30 minutes and filtered through 800 9 of silica gel (EM-60, 230-400 mesh ASTM). The silica gel is washed twice With 500 ml portionS of diethyl ether, and the washings are combined with the filtrate. The combined filtrate and washings are evaporated to dryness at reduced preSsure, 200 ml of diethyl ether is added, and the mixture iS cooled to 0 . The waxy crystals are collected by filtration, washed twice with 100 ml portions of diethyl ether and dissolved in 300 ml of ethyl acetate. The ethyl acetate solution is washed twice with 500 ml portions of saturated aqueous sodium bicarbonate solution and once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and evaporated at reduced pressure to about 1/3 of its original volume. 100 ml of diethyl ether is added, the mixture is cooled to 0 , and the obtained solids are collected by filtration and washed twice with diethyl ether to obtain the product, m.p, 184 -186 , [&alpha;]D26 = +44.31 (CH2C12, c = 0.0058). Exampe 9 : Sodium erythro-(E)-3R,5S-dihydroxy-7-(2'-[4"-fluorophenyl]- naphth-1'-yl)hept-6-enoate (process d); compound no. 11) 5.06 ml of IN. aqueous sodium hydroxide solution (5.06 mmoles) is added to a solution of 2.0 g (5.52 mmoles) of Compound 10 in 160 ml of absolute ethanol, and the reaction mixture is stirred at 20 -25 for 2 hours. 50 g of sodium sulfate is added, and the mixture is stirred for 1 hour and filtered. The salt is washed three times with 100 ml portions of diethyl ether, and the washings are combined with the ethanolic filtrate. The combined lashings and filtrate are evaporated to dryness at reduced pressure, and the crystalline residue is dissolved in chloroform. The chloroform is evaporated at reduced pressure , 300 ml of petroleum ether is added to the residue, and the mixture is stirred for about 60 hours. The solid product is collected by filtration and washed twice with petroleum ether, m.p. 215 -220 (dec.) [&alpha;]D28 = +26.283 (CH3OH, c = 0.0047). Example 10: Ethyl erythro-(E)-3,5-dihydroxy-7-(1'-[4"-luorophenyl]-3' [1"-methylethyl]naphth-2'-yl)hept-6-enoate (Compound no. 13) Step 1 : 1,3-Dimethoxynaphthalene (Reaction BA; compound CXVIa) A solution of 32.1 9 (0.801 mole) of sodium hydroxide in 80,3 ml of water and 96 9 (0.763 mole) of dimethyl sulfate are simultaneously added over a period of 30-45 minutes to 50 9 (0.312 mole) of 1,3-dihydroxy naphthalene in 250 ml of absolute ethanol stirred at -5 - 0 C, the former being added slightly faster than the latter. The reaction mixture is allowed to gradually warm to 20 - 25 C with stirring over a 16 hour period. Most of the ethanol is evaporated at reduced pressure, water is added, and the mixture is extracted three times with methyl t-butyl ether. The extracts are combined, washed with 2N. aqueous sodium carbonate solution, dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure to obtain an oil. The oil is chromatographed on a Waters Prep-500 high pressure liquid chromatography apparatus having a silica gel column and utilizing 5% ethyl acetate/n-hexan-e as the eluant. The fractions containing the product are combined and evaporated at reduced pressure to obtain the product as a yellow oil. step 2 : 2: 1,3-Dimethoxy-2-naphthoic acid (Reaction BC, cow CXYIIa) 62 ml of 1.55M. n-butyllithium/n-hexane (96 mmoles) iS slowly added to 15.04 9 (80 mmoles) of 1,3-dimethoxynaphthalene in 250 ml of anhydrous diethyl ether stirred at 0 C under nitrogen. The reaction mixture is allowed to warm to 20 -25 C and is stirred at thins temperature for 20 hours, the reaction mixture being stirred under nitrogen throughout. Excess anhydrous carbon dioxide is bubbled in for 30 minutes. The reaction mixture iS stirred at 20 -25 C for 4 hours, quenched With water and extracted thoroughly with ethyl acetate. The alkaline aqueous phase is acidified with 2N. hydrochloric acid (to a pH of 1-2) and extracted with ethyl acetate. This ethyl acetate extract is dried over anhydrous sodium sulfate and evaporated to dryness. The residue is dried under high vacuum to obtain the product, m.p. 119 -123 C. step 3 : 1,3-Dimethoxy-2-naphthoyl chloride (Reaction BD; compound CXVIIIa) Analogous to Example 1, Step 1. step 4 : 1,3-Dimethoxy-2-naphthoic acid N-l,l-dimethyl-2-hydroxyethylamide (Reaction BE; compound CXIXa) Analogous to Example 1, Step 2. Steps 5 and 6 : 2-(1',3'-dimethoxynaphth-2'-yl)-4,4-dimethyl-2-oxazoline and its hydrochloride salt (Reactions BF and BG; compound CXXIa = HCl salt Analogous to Example 1, stepS 3 and 4. step 7: 4 4,4-Dimethyl-2-(1'-[4"-fluorophenyl]-3'-methoxynaphth-2'-yl)-2- oxazoline (Reaction BH; compound CXXIIa) A Grignard reagent is prepared by the dropwise addition of 7.7 9 (0.044 mole) of p-bromofluorobenzene to a mixture of 1.1 9 (0.045 mole) of magnesium turnings, one crystal of iodine and 40 ml of dry tetrahydrofuran stirred at 65 C under nitrogen, the addition being at a rate sufficient to maintain reflux without external heating. Upon completion of the addition (30-45 minutes), the reaction mixture is refluxed under nitrogen for 1.5 hours and cooled to obtain a solution of the Grignard reagent. 18 ml of a IM. solution of the Grignard reagent is slowly added to 4.25 9 (14.9 mmoles) of Compound CXXIa in 80 ml of dry tetrahydrofuran (distilled from sodium) stirred at 20 -Z5 C under nitrogen, and the reaction mixture is stirred at 20 -25 C under nitrogen for 16 hours and quenched with ice and saturated aqueous ammonium chloride solution. The mixture is extracted with ethyl acetate, and the ethyl acetate extract is dried over anhydrous sodium sulfate and evaporated to a small volume at reduced pressure to obtain the product. The product is collected by filtration, washed with a small amount of diethyl ether, washed with a small amount of petroleum ether and dried under high vacuum, m. p . 169 -171 C. Step 8 : 4,4-Dimethyl-2-(1'-[4"-fluorophenyl]-3'-[1"-methylethyl]naphth- 2'-yl)-2-oxazoline (Reaction BI; compound CXXIVa) 13.25 ml of 2.M. isopropylmagnesium chloride/diethyl ether (26.5 mmoles) is slowly added to 1.54 g (4.41 mmoles) of Compound CXXIIa in 90 ml of dry tetrahydrofuran (distilled from sodium) and 22 ml of dry toluene (dried over molecular sieves) stirred at 20 -Z5 C, the reaction mixture is stirred at 20 -25 C for 30 minutes and at 70 -80 C for 18 hours, an additional 13.25 ml of 2M. isopropylmagnesium chloride/diethyl ether (26.5 mmoles) iS added, and the reaction mixture is stirred at 70 -80 C for an additional 20 hours, the reaction mixture being maintained under nitrogen throughout. The reaction mixture is quenched with ice and saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The ethyl acetate extract is dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressure. The residue is dissolved in methylene chloride, and the solution is dried over anhydrous sodium sulfate and evaporated to dryness at reduced pressuree. The obtained gum is dissolved in about 10 ml of methylene chloride, a small amount of charcoal is added, and the solution is filtered through a silica gel column utilizing methylene chloride as the eluant. The--fractions containing the product as determined by thin layer chromatography are combined and evaporated to dryness at reduced pressure to obtain the product as an amber-green gum. step 9: 2- 2-(1'-[4"-Fluorophenyl]-3-'-[1"-methylethyl]naphth-2'-yl)- 3,4,4-trimethyl-2-oxazolinium iodide (Reaction R; cmpd. X-X2IIIcj Analogous to Example 1, step 6: m.p. 233 -243 C (dec.). Step 10 : 1-(4-Fluorophenyl)-3-(1'-methylethyl)-2 (Reaction S; compound IVe) 205 mg (9.37 mmoles) of lithium borohydride is added to 2.35 9 (4.67 mmoles) of Compound XXXIIIc stirred in 105 ml of dry tetrahyurofuran (distilled from sodium) and 42 ml of absolute ethanol (dried over molecular sieves) at -30 C under nitrogen. The reaction mixture is stirred at -40 to -30 C under nitrogen for 2 hours and allowed to warm to 0 to 5 C, and 62 ml of 2N. hydrochloric acid is slowly added. The reaction mixture is stirred at 70 -80 C for 2 hours, cooled to 20 -25 C, quenched with water and thoroughly extracted with diethyl ether. The diethyl ether extract is washed with saturated aqueous sodium chloride solution, drie-d over anhydrous sodium sulfate and evaporated to dryness at reduced pressure. The residue is triturated with diethyl ether and then peo7eum ether. The insoluble solids are removed by filtration, and the filtrate is evaporated to dryness at reduced pressure to obtain the crude product as a light orange-yellow sticky solid, m.p. 80 -90 C. step 1 1: (E)-3-(1'-[4"-Fluorophenyl]-3'-(1"-methylethyl)naphth-2'-yl)- prop-2-enat(Reaction W; compound IVF) Analogous to Example 1, step 8: m.p. 102 -105 C. Step 12: Ethyl (E)-7-(1'-[4"-fluorophenyl]-3'-[1"-methylethyl]naphth- 1'-yl)-5-hydroxy-3-oxohept-6-enoate (Reaction A; cmpd. VId) Analogous to Example 1, step 9: m.p. 73-76 C. Step 13 : Ethyl erythro-(E)-3,5-dihydroxy-7-(1'-[4"-fluorophenyl]-3'-[1" methylethyl]naphth-2'-yl)hept-6-enoate (Process a); cmpd. no. 13) Analogous to Example 1, step 10: yellow gummy foam. The principal (erythro) product is a racemate that may be resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former iS preferred. The threo minor product (about 8%) is a racemate that may be resolved into the 3R,5R and 3S,5S isomers, of which the former is preferred. The use of a non-stereoselective reduction would afford all four stereoisomerS in approximately equal amounts. Example 11 : Erythro-(E)-3,5-dihydroxy-7-(1'-[4"-flu methylethyl]naphth-2'-yl)hept-6-enoic acid and its sodium sal t (Process d, cmpds. nos. 14 (acid) and 15 (salt) Analogous to Example 2 (without isolation of intermediate sodium salt). The principal (erythro) product 15 a racemate which may be resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former iS preferred. The minor (threo) product is also a resolvable racemate, the two enantlomerS being the 3R,5R and 3S,5S isomerS, of which the former is preferred. Example 12 : (E)-Trans-6-(2'-[4"'-fluorophenyl)-3"-(1"'-methylethyl) naphth-2"-yl]ethenyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-py 2-one (Process e); compound no. 16) Analogous to Example 3. The crude product is purified by preparative thin layer chromatography on silica gel plates utilizing 2% methanol/methylene chloride as the solvent and ethyl acetate to elute the product from the plates. Evaporation of the ethyl acetate at reduced pressure yields the product as a pale yellow foam. Separation of isomers cf. Example 3. Example 13: Sodium erythro-(E)-3,5-dihydroxy-7-(1'-[4"-fluorophenyl]-3'- [1"-methylethyl]naphth-2'-yl)hept-6-enoate (Process d); compound no. 15) 0.19 ml of 1N. aqueous sodium hydroxide solution is added to 80 mg (0.2 mnole) of Compound no. 16 in 5 mT of absolute ethanol. The reaction mixture is stirred at 20 -25 C for 1 hour and evaporated to dryness at reduced pressure. The residue is dissolved in chloroform, the obtained solution is dried over anhydrous sodium sulfate and evaporated to dryness, and the residue is dried under high vacuum to obtain the product as a pale yellow foam. The principal product is the erythro racemate which may be resolved to obtain the 3R,5S and 3S,5R enantiomers, of which the former is preferred. A very small amount of the threo racemate is present; it may be resolved to obtain the 3R,5R and 3S,5S enantiomers, of which the former i s preferred . Example 14 : Ethyl erythro-(E)-3,5-dihydroxy-7-(1'-[4"-fluorophenyl]-3'- methylnaphth-2'-yl)hept-6-enoate (Compound no. 17) step 1/2 : 1-Methoxy-2-naphthoic acid (Compound no. XXIIIb) l-Hydroxy-2-naphthoic acid is dimethylated substantially as described in Example 5, step 2 and the resultingsthyl 1-methoxy-2-naphthoate hydrolysed substantially according to Example 2: m.p. of product 126 -128 C. steps 3 to 7 : 4,4-Dimethyl-2-(1'-[4"-fluorophenyl]naphth-2'-yl)-2- oxazoline (Reactions M - Q; compound XXXIIc) Analogous to to Example 1, steps 1 to 5: m. p . step 4 product = 95 -97 m.p. step 6 product = 75 -78 m.p. step 7 product (XXXIIc) = 96 -98 step 8 : 4,4-Dimethyl-2-(1'-[4"-fluorophenyl]-3'-methylnaphth-2'-yl)-2- oxazoline (Reaction CA; compound XXXIId) 16.16 ml of 1.7M. n-butyllithium/n-hexane (27.5 mmoles) is added dropwise to 7.9 9 (24.8 mmoles) of Compound XXXIIc in 185 ml of anhydrous diethyl ether stirred at 0 C under nitrogen. The reaction mixture is stirred at 0 C for 30 minutes, 3.9. 9 (27.5 mmoles) of methyl iodide is added and the reaction mixture is allowed to warm to 20 -25 C and stirred at' this temperature for 20 hours, the reaction mixture being maintained under nitrogen throughout. Saturated aqueous sodium chloride solution and additional diethyl ether-are added. The diethyl ether phase is separated, dried over anhydrous sodium sulfate and evaporated at reduced pressure until the onset of turblAiMs, and petroleum ether is added. The precipitate iS washed with petroleum ether and dried under high vacuum, m.p. 125 -129 C. steps 9 to 13: Ethyl erythro-(E)-3,5-dihydroxy-7-(1'-[4"-fluorophenyl]-3'- methylnaphth-2'-yl)hept-6-enoate (Compound no. 17) Analogous to Example 1, Step 6; Example 10, Step 10; Example 1, stepS 8 to 10. m.p. product of step 10 first reaction isolated, 115 -118 m.p. product of step 10 second reaction, 104-107 m. p . product of step 11. 143 -147 m.p. product of Step 12, 89-92 m.p. product of step 13 (compound no. 17), 121 -124 . The product, the erythro racemate, may be resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former is preferred. It cnntains a small amount (less than about 5X) of the corresponding threo compound, a racemate that may be resolved into the 3R,5R and 3S,5S isomers, of which the former is preferred. The use of a non-stereoselective reduction would afford all four stereoisomers in approximately equal amounts. Example 15: Sodium erythro-(E)-3,5-dihydroxy-7-(1'-[4"-fluorophenyl]-3'- methylnaphth-2'-yl)hept-6-enoate (Process d); compound no. 18) Analogous to Example 2 with isolation of sodium salt; m.p. 222 -226 (dec.). The erythro component of the product, the erythro racemate, may be resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former is preferred. The product contains a small amount (less than about 5%) of the corresponding threo, compound also a resolvable racemate, the two enantiomers being the 3R,5R and 3S,5S isomers, of which the former is preferred . Example 16 : Ethyl erythro-(E)-3,5-dihydroxy-7-(3'-ethyl-1'-[4"-fluoro- phenylnaphth-2'-yl)hept-6-enoate (Compound no. 19) Step 1 : 2-(3'-Ethyl-1'-[4"-fluorophenyl]naphth-2'-yl)-4,4-dimethyl-2 oxazoline (Reaction CB; compound XXXIIe) Analogous to Example 14, step 8 starting from XXXIId; m.p. product 106 -109 . step 2 to 6: Ethyl erythro-(E)-3,5-dihydroxy-7-(3'-ethyl-1' phenylnaphth-2'-yl)hept-6-enoate (Compound no. 19) Analogous to Example 1, step 6; Example 10, step 10; Example 1, Steps 8 to 10. m.p. product of Step 2 = 200 (dec.) m.p. product of step 5 = 92 -98Q m.p. product of step 6 = (compound no. 19) = 101 -106 . The principal component of the product, the erythro racemate, may be resolved into two optically pure enantiomers, the 3R,5S and 3S,5R isomers, of which the former is preferred. The use of a non-stereo- selective reduction would afford all four stereoisomers in approximately equal amounts. Example 17 : Erythro-(E)-3,5-dihydroxy-7-(3'-ethyl-1'-[4"-fluorophenyl] naphth-2'-yl)hept-6-enoic acid and its sodium salt (Process d); compound nos. 20 and 21) Analogous to Example 2 (without isolation of intermediate sodium salt), separation of isomers as Example 16. Example 18 : (E)-Trans-6-(2'-[3"-ethyl-1"-(4"'-fluorophenyl)naphth-2"-yl) ethenyl)-4-hydroxy-3,4,5,6-tetrahydropyran-2-one (process e); compound no. 22) Analogous to Examples 3 and 12; m.p. 118 -122 ; separation of isomers cf. Example 3 (about 9% of cis racemate). Example 19 : Sodium erythro-(E)-3,5-dihydroxy-7-(3'-ethyl-1'-[4"-fluoro phenyl]naphth-2'-yl)hept-6-enoate (process d) compound no. 21) Analogous to Example 13 starting from compound no. 22. The principal component of the product is the erythro racat which may be resolved to obtain the 3R,5S and 3S,5R enantiomers, of which the former is preferred. The product contains a small amount of the corresponding threo racemate, which may be resolved to obtain the 3R,5R and 3S,5S enantiomers, of which the former is preferred. TABLE I The following compounds of Groups IAa1-IAa3 may be synthesized by the processes set forth above: Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 R7 Isomer m.p. No. R5a Group Group 1 H H H 4-F H 2 (E)CH=CH 1 H C2H5 E 114-116 12 H H H 4-F H 2 " 1 H C2H5 4 en antiomers gum 2 H H H 4-F H 2 " 1 H H E 43-102 3 H H H 4-F H 2 " 1 H Na E 210-220 (dec.) 6 4-Cl H H 4-F H 2 " 1 H C2H5 E 121-124 Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R5 R7 Isomer m.p. No. R5a Group Group 7 4-Cl H H 4-F H 2 (E)CH-CH 1 H H E oil 8 4-Cl H H 4-F H 2 " 1 H Na E 201-204 (dec.) 11 H H H 4-F H 2 " 1 H Na E(3R,5S) 215-220 (dec.) 13 3-iC3H7 H H 4-F H 1 " 2 H C2H5 E gummy foam 14 3-iC3H7 H H 4-F H 1 " 2 H H E Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 R7 Isomer m.p. No. R5a Group Group 15 3-iC3H7 H H 4-F H 1 (E)CH=CH 2 H Na E foam 17 3-CH3 H H 4-F H 1 " 2 H C2H5 E 121-124 18 3-CH3 H H 4-F H 1 " 2 H Na E 222-226 (dec. 19 3-C2H5 H H 4-F H 1 " 2 H C2H5 E 101-106 20 3-C2H5 H H 4-F H 1 " 2 H H E oil Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 R7 Isomer m.p. No. R5a Group Group 21 3-C2H5 H H 4-F H 1 (E)CH=CH 2 H Na E > 230 (dec.) 23 H H H 4-F H 2 -CH2CH2- 1 H C2H5 E Gum 24 H H H 4-F H 2 " 1 H Na E 180-190 25 H H H 4-F H 2 " 1 H H E Solid foam 26 4-Cl H H 4-F H 2 (E)CH=CH 1 H K E 27 4-CH3 H H 4-F H 2 " 1 H C2H5 E Position Position of R4-bear- of -X-Z Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- Group R6 R7 Isomer m.p. No. R5a Group 28 4-CH3 H H 4-F H 2 (E)CH=CH 1 H Na E 29 4-CH3 H H 4-F H 2 " 1 H H E 30 3-CH3 H H 4-F H 1 " 2 H K E 31 3-CH3 H H 4-F H 1 " 2 H H E 32 3-CH3 H H 4-F H 1 -CH2CH2- 2 H C2H5 E Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 R7 Isomer m.p. No. R5a Group Group 33 3-CH3 H H 4-F H 1 -CH2CH2- 2 H Na E 34 3-CH3 H H 4-F H 1 -CH2CH2- 2 H H E 35 1-CH3 H H 4-F H 3 (E)CH=CH 2 H C2H5 E 36 1-CH3 H H 4-F H 3 " 2 H K E 37 1-CH3 H H 4-F H 3 " 2 H H E 38 1-CH3 H H 4-F H 3 -CH2CH2- 2 H CH3 E Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 R7 Isomer m.p. No. R5a Group Group 39 1-CH3 H H 4-F H 3 -CH2CH2- 2 H Na E 40 1-CH3 H H 4-F H 3 -CH2CH2- 2 H H E 41 H H H H H 2 (E)CH=CH 1 H C2H5 E 42 H H H H H 2 1 H K E 43 H H H H H 2 1 H H E Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 R7 Isomer m.p. No. R5a Group Group 44 H 6-OC6H5 7-CH3 3-CF3 H 2 -CH2- 1 CH3 CH3 E 45 H 6-OC6H5 7-CH3 2-CF3 H 2 -CH2- 1 CH3 Na E 46 H 6-OC6H5 7-CH3 3-CF3 H 2 -CH2- 1 CH3 H E 47 H H H 4-F H 1 (E)CH=CH 2 H C2H5 E oil 48 H H H 4-F H 1 ' 2 H Na E > 220 C. (dec.) 49 H H H 4-F H 1 -CH2CH2- 2 H C2H5 E Oil Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 R7 Isomer m.p. No. R5a Group Group 50 H H H 4-F H 1 -CH2CH2- 2 H Na E > 190 C. (dec.) 51 H H H 4-F H 3 (E)CH=CH 2 H C2H5 E Gum 52 H H H 4-F H 3 2 H H E Solid foam 53 H H H 4-F H 3 " 2 H Na E 225 -230 C (dec.) TABLE II The following compounds of Groups IAb1-IAb3 may be synthesized by the processes set forth above: Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 Isomer m.p. No. R5a Group Group 152-154 4 H H H 4-F H 2 (E)CH=CH 1 H trans (no detectable cus 153-156 ) 9 4-Cl H H 4-F H 2 " 1 H trans 131-134 10 H H H 4-F H 2 " 1 H trans 184-186 (5S,4R) 16 3-iC3H7 H H 4-F H 1 " 2 H trans foam 22 3-C2H5 H H 4-F H 1 " 2 H trans 118-122 Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 Isomer m.p. No. R5a Group Group 54 H H H 4-F H 2 -CH2CH2- 1 H trans Solid foam 55 4-CH3 H H 4-F H 2 (E)CH=CH 1 H trans 56 3-CH3 H H 4-F H 1 " 2 H trans 57 3-CH3 H H 4-F H 1 -CH2CH2- 2 H trans 58 1-CH3 H H 4-F H 3 (E)CH=CH 2 H trans 59 1-CH3 H H 4-F H 3 -CH2CH2- 2 H trans Position of R4-bear- Position Cmpd. R1 R2 R3 R4 R5' ing Phenyl -X- of -X-Z R6 Isomer m.p. No. R5a Group Group 60 H H H H H 2 (E)CH=CH 1 H trans 61 H 6-OC6H5 7-CH3 3-CF3 H 2 -CH2- 1 H trans 62 H H H 4-F H 2 (E)CH=CH 1 H cis 143 -145 C. mixture: ¯53% cis 63 H H H 4-F H 2 " 1 H ¯47% trans 134 -137 C. 64 H H H 4-F H 1 -CH2CH2- 2 H trans Oil 65 H H H 4-F H 3 (E)CH=CH 2 H trans Solid foam Table III The following compounds of Groups IBa1-IBa3 may be synthesized by the processes set forth above: Position Position of R4-bear- of -X-Z Cmpd. R1 R4 R5, ing Phenyl -X- Group R6 R7 Isomer m.p. No. R5a Group 5 H 4-F H 2 (E)CH=CH 1 H C2H5 E Gum 66 H 4-F H 2 -CH2CH2- 1 H K E 67 H 4-F H 2 -CH2CH2- 1 H H E 68 H 4-F H 2 (E)CH=CH 1 H C2H5 E Gum 69 H 4-F H 2 " 1 H Na E 220 -225 C. (dec.) 70 H 4-F H 2 " 1 H H E 71 4-Cl 4-F H 2 " 1 H C2H5 E Position Position of R4-bear- of -X-Z Cmpd. R1 R4 R5, ing Phenyl -X- Group R6 R7 Isomer m.p. No. R5a Group 72 4-Cl 4-F H 2 (E)CH=CH 1 H K E 73 4-Cl 4-F H 2 " 1 H H E 74 4-CH3 4-F H 2 " 1 H C2H5 E 75 4-CH3 4-F H 2 " 1 H Na E 76 4-CH3 4-F H 2 " 1 H H E 77 3-CH3 4-F H 1 " 2 H C2H5 E Position Position of R4-bear- of -X-Z Cmpd. R1 R4 R5, ing Phenyl -X- Group R6 R7 Isomer m.p. No. R5a Group 78 3-CH3 4-F H 1 (E)CH=CH 2 H K E 79 3-CH3 4-F H 1 " 2 H H E 80 3-CH3 4-F H 1 -CH2CH2- 2 H C2H5 E 81 3-CH3 4-F H 1 -CH2CH2- 2 H Na E 82 3-CH3 4-F H 1 -CH2CH2- 2 H H E 83 1-CH3 4-F H 3 (E)CH=CH 2 H C2H5 E 84 1-CH3 4-F H 3 " 2 H K E EMI80.1 <SEP> Position <SEP> Position <tb> <SEP> of <SEP> R4-bear- <SEP> of <SEP> -X-Z <tb> Cmpd. <SEP> R1 <SEP> R4 <SEP> R5, <SEP> ing <SEP> Phenyl <SEP> -X- <SEP> Group <SEP> R6 <SEP> R7 <SEP> Isomer <SEP> m.p. <tb> No. <SEP> R5a <SEP> Group <tb> 85 <SEP> 1-CH3 <SEP> 4-F <SEP> H <SEP> 3 <SEP> # <SEP> 2 <SEP> H <SEP> H <SEP> E <tb> 86 <SEP> 1-CH3 <SEP> 4-F <SEP> H <SEP> 3 <SEP> -CH2CH2- <SEP> 2 <SEP> H <SEP> C2H5 <SEP> E <tb> 87 <SEP> 1-CH3 <SEP> 4-F <SEP> H <SEP> 3 <SEP> -CH2CH2- <SEP> 2 <SEP> H <SEP> Na <SEP> E <tb> 88 <SEP> 1-CH3 <SEP> 4-F <SEP> H <SEP> 3 <SEP> -CH2CH2- <SEP> 2 <SEP> H <SEP> H <SEP> E <tb> 89 <SEP> H <SEP> H <SEP> H <SEP> 2 <SEP> # <SEP> 1 <SEP> H <SEP> C2H5 <SEP> E <tb> 90 <SEP> H <SEP> H <SEP> H <SEP> 2 <SEP> # <SEP> 1 <SEP> H <SEP> K <SEP> E <tb> 91 <SEP> H <SEP> H <SEP> H <SEP> 2 <SEP> # <SEP> 1 <SEP> H <SEP> H <SEP> E <tb> Position Position of R4-bear- of -X-Z Cmpd. R1 R4 R5, ing Phenyl -X- Group R6 R7 Isomer m.p. No. R5a Group 92 H 3-CH3 4-OCH3 2 -CH2- 1 CH3 CH3 E 93 H 3-CH3 4-OCH3 2 -CH2- 1 CH3 Na E 94 H 3-CH3 4-OCH3 2 -CH2- 1 CH3 H E 95 H 4-F H 3 (E)CH=CH 2 H C2H5 E Gum 96 H 4-F H 3 " 2 H H E Solid foam 97 H 4-F H 3 " 2 H Na E 215 -230 C. (dec.) Table IV EMI82.1 The <SEP> following <SEP> compounds <SEP> of <SEP> Groups <SEP> IBb1-IBb3 <SEP> may <SEP> be <SEP> synthesized <SEP> by <SEP> the <SEP> processes <SEP> set <SEP> forth <SEP> above: <tb> <SEP> Position <SEP> Position <tb> <SEP> of <SEP> R4-bear- <SEP> of <SEP> -X-Z <tb> <SEP> ing <SEP> Phenyl- <SEP> -X- <SEP> Group <SEP> R6 <SEP> Isomer <SEP> m.p. <tb> Cmpd. <SEP> R1 <SEP> R4 <SEP> R5, <SEP> Group <tb> No. <SEP> R5a <tb> 98 <SEP> H <SEP> 4-F <SEP> H <SEP> 2 <SEP> -CH2CH2- <SEP> 1 <SEP> H <SEP> trans <SEP> 188-191 C. <tb> 99 <SEP> H <SEP> 4-F <SEP> H <SEP> 2 <SEP> # <SEP> 1 <SEP> H <SEP> trans <tb> 100 <SEP> 4-Cl <SEP> 4-F <SEP> H <SEP> 2 <SEP> # <SEP> 1 <SEP> H <SEP> trans <tb> 101 <SEP> 4-CH3 <SEP> 4-F <SEP> H <SEP> 2 <SEP> # <SEP> 1 <SEP> H <SEP> trans <tb> 102 <SEP> 3-CH3 <SEP> 4-F <SEP> H <SEP> 2 <SEP> # <SEP> 2 <SEP> H <SEP> trans <tb> 103 <SEP> 3-CH3 <SEP> 4-F <SEP> H <SEP> 1 <SEP> -CH2CH2- <SEP> 2 <SEP> H <SEP> trans <tb> 104 <SEP> 1-CH3 <SEP> 4-F <SEP> H <SEP> 3 <SEP> # <SEP> 2 <SEP> H <SEP> trans <tb> Position Position of R4-bear- of -X-Z ing Phenyl- -X- Group R6 Isomer m.p. Cmpd. R1 R4 R5, Group No. R5a 105 1-CH3 4-F H 3 -CH2CH2- 2 H trans 106 H H H 2 (E)CH=CH 1 H trans 107 H 3-CH3 4-OCH3 2 -CH2- 1 CH3 trans 108 H 4-F H 2 (E)CH=CH 1 H cis 109 H 4-F H 3 " 2 H trans Solid foam 110 H 4-F H 2 " 1 H trans 168 -172 C. In Tables I and III, E = erythro racemate (two stereoisomers unless otherwise stated) In Tables II and Iv, cis and trans refer to the relative positions of the R6 group in the 4-position and the hydrogen atom in the 6-position of the lactone ring (racemates unless otherwise stated) The principal component of each of Compounds 23-25, 32-34, 38-40, 44-46, 49, 50, 66, 67, 80-82, 86-88 , 92-94 is the erythro racemate which may be resolved, the two enantiomers being the 3R,5R and 3S,5S isomers. The minor component (usually about 1-15%) of each example is the corresponding threo racemate which may be separated therefrom and resolved to obtain the 3R,5S and 3S,5R isomers. If, however, a non- stereoselective process were utilized in process a) to reduce the 3-oxo group to the 3-hydroxy group, a resolvable mixture containing approximately equal amounts of the four stereoisomers would be obtained. Preferred are the 3R,5R and 3R,5S isomers and the racemate of which each is a constituent, viz., the 3R,5R-35,5S and 3R,55-35,5R racemates, with the 3R,5R isomer and the jR,5R-3S,5S racemate being more preferred. The principal component of each of Compounds 26-31, 35-37, 41-43, 47, 48, 51-53, 68-79, 83-85, 89-91, 95-97 is likewise ther erythro racemate which may be resolved into two optically pure enantiomers, viz., the 3R,5S and 3S,5R isomerS. The minor component (usually about 1-15%) of each example is the corresponding threo racemate which may be separated therefrom and resolved to obtain the 3R,5R and 3S,5S isomers. If, however, a non-stereoselective proceSs were utilized in process a) to reduce the 3-oxo group to the 3-hydroxy group, a resolvable mixture containing approximasely equal amounts of the four stereoisomers would be obtained. Preferred are the 3R,5R and 3R,5S isomers anÅa the racemate of which each is a constituent, viz., the 3R,5R-3S,5S and 3R,5S-3S,5R racemates, with the 3R,5S isomer and the 3R,5S-3S,5R racemate being more preferred. The principal component of each of Compounds 54, 57, 59. 51, 64, 98, 103, 105 and 107 is the trans racemate which may be resolved into two optically pure enantiomers, viz., the 4R,6R and 4S,6S isomers. The minor component (usually about 1-15%) of each example is the corresponding cis racemate which may be separated therefrom and resolved to obtain the 4R,6S and 4S,6R isomers. The use in process e) of a mixture containing approximately equal amountS of the four stereoisomeric carboxylic acids would yield a mixture containing aPproximately equal amounts of the four stereoisomeric lactones. Preferred are the 4R,6R and 4R,6S isomers and the racemate of which each is a constituent, with the 4R,6R isomer and the 4R,6R-4S,6S racemate being more preferred. The principal component of each of Compounds 55, 56, 58, 60, 6s, 99-102, 104, 106, 109, 110 is the trans racemate which may be resolved into two optically pure enantiomerS, viZ;, the 4R,6S and 4S,6R isomers. The minor component (usually about 1-15%) of each example iS the corresponding cis racemate which may be separated therefrom and resolved to obtain the 4R,6R and 4S,6S isomers. The use in process e) of a mixture containing approximately equal amounts of the four stereoisomeric carboxylic acids would yield a mixture containing approximately equal amounts of the four stereoisomeric lactones as in Compound 63. Preferred are the 4R,6R and 4R,6S isomers and the racemate of which each is a constituent, with the 4R,6S isomer and the 4R,6S-4S,6R racemate being more preferred. The principal component of each of Compounds 62 and 108 is the cis racemate which may be resolved into two optically pure enantiomers, viz., the 4R,6R and 4S,6S isomerS. The minor component (usually about 1-15%) of each example is the corresponding trans racemate which may be separated therefrom and resolved to obtain the 4R,65 and 4S,6R isomers. The preferred isomers are ad indicated in the preceding paragraph. Each of the compounds of the examples wherein R7 is a cation may be converted into the corresponding free acid and into the corresponding compounds wherein R7 is a different M by conventional means. I Throughout the examples, the term "reduced pressure" denotes aspirator pressure, and where no solvent is specified in connection with a solution, the solvent is water. All solvent mixtures are by volume. The following data were obtained for the preceding compounds. Unless otherwise stated the data are NMR spectra measured at 200 mHz. Shifts are in ppm. relative to tetramethylsilane. Abbreviations: s = singlet d = doublet dd = doublet of a doublet t = triplet q = quartet m = multiplet br = broad bm = broad multiplet bs = broad singlet Cmpd. No. 2 CDC13: (90mHz); 1.59(m,2H); 2.53(d,2H,J-2.5Hz); 4.24(m,1H); 4.52(m,1H); 5.62(m,1H); 6.83(m,1H); 7.23(m,7H); 7.79(m,2H); 8.13(m, 1H) . 5 CDC13: 1.23(t,3H,J=1.5Hz); 1.42(m,6H); 1.8(m,2H); 2.4(m,2H); 2.8(m,4H); 3.12(m,2H); 3.78(m,2H), 4.16(q,2H,J=1.5Hz); 7.15(m,4H); 7.52(m,1H); 7.82(m,1H). i2 CDC13: 1.28(t,3H,J=1.5Hz); 1.6(m,2H); 2.43(m,2H); 2.95(br,2H); 4.2(q,2H,J=1.5Hz); 4.2(br,1H); 4.51(br,1H); 5.65(m,1H); 6.9(dd,1H,J=3 and 3 Hz); 7.07 (t,2H,J=1.5Hz); 7.41(m,5 7.82 (m,2H); 8.17(m.1H). 13 * CDC13: 1.31(m,11H); 2.41(m,2H); 2.88(s,1H); 3.32(m,1H); 3.61(s,1H); 4.09(m,1H); 4.19(q,2H,J=lHz); 4.33 (m,lH); 5.28(m,1H); 6.54(d,1H,J=2Hz); 7.23(m,7H); 7.77(m,2H). 14 CDCl3: 1.3 (m,8H); 2.49(d,2H); 3.3(m,1H); 3.57(bm,1H); 4.12(bm,2H); 4.36(m,1H); 5.3(dd,1H,J=1.5Hz); 6.56(d,1H,J=3Hz); 7.25(m,8H); 7.78(m,2H). 15 D20: O.9(m,7H); 1.27(m,1H); 2.03(m,2H); 3.0(m,1H); 3.43(m,1H); 3.97(m,1H); 4.9(m,1H); 6.29(d,1H,J=2Hz); 6.72(m,7H); 7.26(m,2H); 16 CDCl3: 1.3(m,6H); 1.45(bm,2H); 1.82(bs,1H); 2.61(m,2H); 3.3(m,1H); 4.12(m,1H); 5.1(m,1H); 5.31(dd.1H,J=lHz); 6.64(d,1H,J=2.5Hz); 7.25(m,7H); 7.78(m,2H). 18 CD3SOCD3: l.l(m,2H); 1.85(m,2H); 2.5(s,3H); 3.5(m,1H); 4.1(m,1H); 5.4(q,1H,J=1.25Hz); 6.3(d,1H,J=3.5Hz); 7.3(m,7H); 7.83(m,2H) . 21 CDCl3 + CD30D: 1.25(m,2H); 1.35(t,3H,J=1.5Hz); 2.25(m,2H); 2.89(q,2H,J=1.5Hz); 3.88(m,1H); 4.27(m,1H); 5.39(q,1H,J=1.5Hz); 6.52(d,1H,J=3Hz); 7.25(m,5H); 7.72(m,4H). Cmpd. No. 23 CDCl3: 1.29(t,3H,J=1.5HzJ; 1.80(m,4H); 2.43(m,2H), 3.13(m,2H); 3.92(m,2H); 4.20(q,2,J=1.5Hz); 7.25(m,5H); 7.56(t,2H,J=1.5Hz); 7.75(d,1H,J=1.5Hz); 7.90(d,1H,J=1.5Hz); 8.17(m,1H). 25 CDCl3: 1.45(m,2H), 1.80(m,2H); 2.45(m,2H); 3.10(m,2H); 3.95(bm,2H); 7.6(bm,10H). 47 CDCl3: 1.26(t,3H,J=1.5Hz); 1.75(m,2H); 2.49(d,2H,J=1.33Hz); 3.13(d,1H,J=0.5Hz); 3.66(d,1H,J=0.5Hz); 4.17(q,2H,J=1.5Hz); 4.25(m,1H); 4.45(m,1H), 6.23(dd,1H,J=1.5 and 2 Hz); 6.47(d,1H,J=3.5Hz); 7.25(m,4H); 7.4(m,3H); 7.8(m,3H). 49 CDCl3: 1.23(t,3H,J=1.5Hz); 1.40(m,2H); 1.65(m,2H); 2.41(d,2H, J=1.5Hz); 2.60(m,2H); 3.25(d,1H,J=0.5Hz); 3.70(d,1H,J=0.5Hz); 3.75(m,1H), 4.15(q,2H,J=1.5Hz); 4.2(m,1E4); 7.3(m,SH); 7.83(m, 2H) . 51 CDCl3; 1.27(t,3H,3=1.5Hz); 1.72(m,2H); 2.5(d,2H,3=1.5Hz) 3.22(s,1Hl; 3.69ts,1H); 4.15(q,2H,J=1.5Hz); 4.27(m,1H); 4.51(m,1H); 6.22(dd,1H,J=3 and 1.S Hz); 6.61(d,1H,J=3Hz); 7.11(t,2H,J=2Hz); 7.38(m,4H); 7.67(s,1H); 7.78(m,2H); 7.97(s, 1H) . 52 CDC13: 1.73(m,2H); 2.55(d,2H,J=1.5Hz); 4.3(m,1H); 4.5(m,1H); 6.2(dd,1H,J=3 and 1.5 Hz); 6.6(d,1H,J=3Hz)3 7.1(m,2H); 7.4(m,4H); 7.66(s,1H); 7.78(m,2H); 7.97(s,1H). 54 CDCl3: 1.82(m,4H); 2.67(m,2H); 3.05(m,1H); 3.26(m,1H); 4.32(m,1H); 4.61(m,1H); 7.10tm,2H); 7.28(m,3H), 7.51(m,2H); 7.72(d,1H,J=1.5Hz); 7.86(m,1H); 8.11(d,1H,J=1.5Hz). 64 CDC13: 1.7(m,2H); 1.7(m,2H); 1.75(sf1H); 2.7(m,2H), 2,7(m,2H); 4.35(m,1H); 4.56(m,1H); 7.3(m,8H); 7.85td,2H). Cmpd. No . 65 CDC13: 2.0(m,2H); 2.71(m,2H); 4.41(m,1H); 5.29(m,1H); 6.23(dd,1H,J=3 and 1.5 Hz); 6.7(d,1H,J=3Hz); 7.13(m,2H); 7.41(m,4H); 7.68(s,1H); 7.79(m,2H); 7.98(s,1H). 68 CDC13: 1.3(t,3H,J=1.5Hz); 1.75(m,6H); 2.43(m,2H); 2.78(m,4H); 4.18(m,3H); 4.37(m,1H); 5.25(dd,1H,J=3 and 1.5 Hz); 6.5(d,1H,J=3Hz); 7.02(m,3H); 7.22(m,3H). 95 CDCl3: 1.24(t,3H,J=1.5Hz); 1.76(m,6H); 2.5(m,2H); 2.8(m,4H); 4.17(m,3H); 4.14(m,1H); 6.06(dd,1H,J=3 and 1.5 Hz); 6.5(ds lH,J=3Hz); 7.1 (m,6H) . 96 CDC13: 1.83(m,6H); 2.69(m,6H); 4.26(m,1H); 4.43(m,1H); 6.06(m,1H), 6.52(m,1H); 7.12(m,6H). 109 CDCl3: 1.96(m,6H); 2.73(m,6H); 4.4(m,1H); 5.22(m,1H); 6.1(dd,1H,J=3 and 1.5 Hz); 6.57(d,1H,J=3Hz); 7.17(m,6H).

Claims: Claims: 1. A compound of formula I EMI90.1 wherein the two groups Ro together form a radicaT of formula EMI90.2 or -(CH2)4wherein R2 is hydrogen, C1-4alkyl, C1-4alkoxy, (except t-butoxy), trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, R3 is hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxys with the provisos that not more than one of R2 and R3 L is trifluoromethyl, not more than one of R2 and R3 is phenoxy, and not more that one of R2 and R3 is benzyloxy, R1 is hydrogen, C1-6alkyl, fluoro, chloro or benzyloxy, R4 is hydrogen, C1-4alkyl, C1-4alkoxy, (except t-butoxy), trifluoromethyl, fluoro, chloro, phe7zoxy or benzyloxy, R5 is hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, trifluoromethy' 3U phenoxy or benzyloxy, R5a is hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, and with the provisos that not more than one of R4 and R5 is trifluoromethyl, not more than one of R4 and R5 is phenoxy and not more than one of R4 and R5 is benzyloxy, X is -(CH2)n-, EMI91.1 wherein n is 0, 1, 2 or 3 and both q'S are O or one is 0 and the other is 1 EMI91.2 wherein R6 is hydrogen or Cl 3alkyl, u with the general proviso that -X-Z and the R4 bearing phenyl group are ortho to each other, in free acid form or in the form of a physiologically-hydrolysable and -acceptable ester or a # lactone thereof or in salt form. 2. A compound according to Claim 1 wherein R0, R1, R2, R3, R4, R5 R5a, X and Z have meanings selected from those hereinbefore defined in Groups ( i ) to (cxx). 3. Erythro-(E)-3R,5S,dihydroxy-7-(2'-[4"-fluorophenyl]naphth-1' yl)hept-6-enoate or a salt thereof. 4. Erythro-(E)-3,5-dihydroxy-7-(1'-[4"-fluorophenyl]-3'-[1'-methyl ethyllnaphth-2'-yl)hept-6-enoate or a salt thereof. 5. (E)-Trans-6-(2'-[3"-ethyl-1"-(4"'-fluorophenyl)naphth-2"-yl]ethenyl)-4-hydroxy-3,4,5,6-tetrahydropyran-2-one. 6. A compound according to Claim 3 or 4 in sodium salt form. 7. A pharmaceutical composition comprising a compound according to any one of Claims 1 to 6 as appropriate in free acid form or in the form o; a physiologically-hydrolysable and -acceptable ester or a lactone thereof or in pharnzaceutically acceptable salt form, together with a pharmaceutically acceptable diluent or carrier. 8, A method of inhibiting chlolesterol biosynthesis or treating atherosclerosis by administering to a subject in need of such treatment an effective amount of a compound according to any one of Claims 1 to 6 as appropriate in free acid form or in the form of a physiologicallyhydrolysable and -acceptable ester or a lactone thereof or in pharmaceutically acceptable salt form. 9. The use of a compound according to any one of Claims 1 to 6 as appropriate in free acid form or in the form of a physiologically-hydrolysable and -acceptable ester or a lactone thereof or in pharmaceutically acceptable salt form in inhibiting cholesterol biosynthesis or treating atherosclerosis. 10. A compound according to any one of Claims 1 to 6 as appropriate in free acid form or in the form of a physiologically-hydrolysable and -acceptable ester or a lactone thereof or in pharmaceutically acceptable salt form for use as a pharmaceutical. 11. A compound according to any one of Claims 1 to 6 as appropriate in free acid form or in the form of a physiologically-hydrolysable and -acceptable ester or a lactone thereof or in pharmaceutically acceptable salt form for use in inhibiting cholesterol biosynthesis or treating atherosclerosis. 12. A process for preparing a compound according to Claim 1 which comprises a) When R6 is hydrogen reducing a compound of formula VI 6 EMI93.1 wherein R14 is a radical forming a physiologically-hydrolysable and acceptable ester and X, is as defined above, b) when R6 = C1-3alkyl, hydrolysing a compound of formula XVII EMI93.2 wherein R6a is C1-3alkyl, R15 is part of an ester forming group and X and Rl4 are as defined above, c) when X is EMI93.3 deprotecting a compound of formula LIX EMI93.4 wherein Pro is a protecting group d) hydrolysing a compound of formula I in the form of a physiologically hydrolysable ester or a lactone or e) esterifyingor lactonising a compound of formula I in free acid form, and when a free carboxyl group is present, recovering the compound obtained in free acid form or in the form of a salt, whereby ## representS the basic ring structure EMI94.1 R0, R1, R4, R5a, $R5, X and Z aS defined in Claim 1. 13. A process for preparing a compound of formula I which comprises hydrolysing a compound of formula I in ester or lactone form or esterifying or lactonising a compound of formula I in free acid form and when a free carboxyl group iS present recovering the compound obtained in free acid form or in the form of a salt. 14. A compound of formula VI, XII, XV, XVII, XXVIII-XXX, XXXII, XXXIII, XXXV-XL, XLII-L, LII-LIV, LVI-LVIII, CXIX-CXXII, CXXIY-CXXVII, CXXXI or CXXXII as hereinbefore defined.

Inventors: ANDERSON, PAUL LEROY
Applicants: SANDOZ AG, SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H., SANDOZ-PATENT-GMBH
Application year: 1984
Main classification: C07C59
IPC codes: C07F7, C07C45, C07C25, C07C29, C07C47, C07D309, C07C59, C07C33, C07C17, C07C67, C07C235, C07C49, C07C69, C07C43, C07C31, C07C27, C07D263, C07C41, C07C37