FLUORAN COMPOUNDS

Abstract: A 2-(chloro-substituted benzylamino)-6-dibutylamino-­ fluoran compound represented by the general formula:

Description: FLUORAN COMPOUNDS The present invention relates to novel fluoran compounds. More particularly, the present invention relates to 2-(chloro-substituted benzylamino)-6dibutylamino-fluoran compounds useful as a coloring material for heat or pressure sensitive record sheets. As a typical conventional fluoran compound, (A-1) 2-benzylamino-6-diethylamino fluoran represented by the formula: EMI1.1 is well known (Japanese Examined Patent Publication No. 4614/1971), which undergoes color-development when brought in contact with an acidic substance. Also known are (A-2) 2-(2-chlorobenzylamino)-6-diethylamino fluoran represented by the formula: EMI1.2 and (A-3) 2-(4-chlorobenzylamino)-6-diethylamino fluoran represented by the formula: EMI2.1 (U.S. Patent No. 3,825,561). The present inventors have found that novel fluoran compounds which are similar to the conventional fluoran compounds but have an N,N-dibutylamino group at the 6-position instead of the N,N-diethylamino group and a chloro-substituted benzylamino group at the 2-position, have superior properties as a coloring material for heat or pressure sensitive record sheets. Namely, the present invention provides 2-(chloro substitutedbenzylamino)-6-dibutylamino-fluoran compounds represented by the formula: EMI2.2 The fluoran compounds of the formula I are novel compounds, which are substantially colorless solid and which, when brought in contact with an acidic substance, i.e. an electron acceptor such as an organic acid, an acid clay, an activated acid clay, a phenol resin, a metal salt of an aromatic carboxylic acid, or bisphenol A, readily form coloring agents having a deep greenish black color. The coloring agents thus developed, have superior properties useful for a coloring material for heat or pressure sensitive record sheets. As compared with the conventional fluoran compounds, the fluoran compounds of the general formula I are superior in (1) the solubility in an organic solvent, when used for pressure sensitive record sheets, and (2) the rising for color-development, (3) the low temperature color development and (4) the resistance to self-color development under humidity, when used for heat sensitive record sheets. Thus, they are extremely useful for a color developing record material. Now, the present invention will be described in detail with reference to the preferred embodiments. The fluoran compounds of the formula I include the following specific compounds: (B) 2-(2-chlorobenzylamino)-5-di-n-butylamino-fluoran of the formula: EMI3.1 (C) 2-t3-chlorobenzylamino)-6-di-n-butylamino-fluoran of the formula: EMI4.1 (D) 2-(4-chlorobenzylamino)-6-di-n-butylamino-fluoran of the formula: EMI4.2 The solubility of the fluoran compounds (B), (C) and (D) of the present invention in organic solvents was compared with that of the above-mentioned conventional fluoran compounds (A-1), (A-2) and (A-3), and the results are shown in Table 1. Table 1 Comparison in the solubility (% by weight) in organic solvents (at 500C) EMI5.1 <tb> <SEP> Compounds <SEP> KMC-113 <SEP> # <SEP> Hyzole-296 <tb> <SEP> (A-l) <SEP> # <SEP> 0.44% <SEP> 1.40% <SEP> <tb> onventional <SEP> (A-2) <SEP> 1.20% <SEP> # <SEP> 1.80% <tb> compounds <tb> <SEP> (A-3) <SEP> 1.90% <SEP> 3.10% <tb> <SEP> (B) <SEP> 3.30% <SEP> 4.80% <tb> Compounds <SEP> of <tb> the <SEP> present <SEP> (C) <SEP> 4.20% <SEP> 6.30% <tb> invention <SEP> <tb> <SEP> (D) <SEP> 3.80% <SEP> 7.20% <tb> Note: KMC-113 is an alkyl naphthalene compound manufactured by Kureha Chemical Industry Co. Ltd., and Hyzole-296 is a diallylethane compound manufactured by Nippon Petrochemical Co. Ltd. Both are organic solvents commonly used for pressure sensitive record sheets. As shown in Table 1, the fluoran compounds (B), (C) and (D) of the present invention are superior to the conventional fluoran compounds (A-l), (A-2) and (A-3) in the solubility in the organic solvents and thus have good oil compatibility which is essential for a color developing material. The present inventors have conducted extensive researches for fluoran compounds to be used for heat sensitive record sheets which have no substantial self-color development, a high developed color density, a low color-development initiation temperature, a high rising for color development and excellent resistance to self-color development under humidity, and have found that the fluoran compounds of the formula I have excellent properties to satisfy the above requirements. The fluoran compounds of the formula I of the present invention may be prepared by the following method (1) or (2). (1) A benzylamine compound represented by the general formula: EMI6.1 where R is a hydrogen atom or a lower alkyl group, and 2-(2-hydroxy-4-diDutylamino)benzoyl-benzoic acid of the formula: EMI7.1 are reacted at a temperature of from 0 to 80 C for from a few hours to some 10 hours in the presence of a condensing agent such as concentrated sulfuric acid. After the reaction, the reaction mixture is poured into water, and an aqueous sodium hydroxide solution is added to bring the pH to from 8 to 10. The precipitate thereby formed, is collected by filtration. To the cake, toluene and an aqueous solution containing from 5 to 10% by weight of sodium hydroxide are added, and the mixture is stirred for 1 to 3 hours under reflux. The toluene layer is separated by liquid phase separation, washed with water and concentrated. The precipitated crystals are collected by filtration. By the filtration of the crystals, a 2-(chloro-substituted benzylamino)-6-dibutylamino-fluoran compound of the formula I is obtainable in high purity and good yield. If necessary, the product is recrystallized from an organic solvent such as methanol, ethanol, toluene or acetone. (2) 2-Amino-6-dibutylamino-fluoran of the formula: EMI7.2 is reacted with a chloro-substituted benzylchloride represented by the general formula: EMI8.1 in water or in a volatile organic inert solvent in the presence of an acid-binding agent such as sodium hydroxide, sodium carbonate or sodium hydrogen carbonate, whereby a fluoran compound of the formula I is obtainable. From the practical point of view, the method (1) is preferred. As the condensing agent to be used in the present invention, there may be mentioned concentrated sulfuric acid, acetic acid anhydride, phosphoric acid, polyphosphoric acid, phosphorus oxychloride and zinc chloride. From the practical point of view, it is preferred to use concentrated sulfuric acid. Now, the present invention will be described in further detail with reference to Examples for the preparation of typical 2-(chloro-substituted benzylamino)-6-dibutylamino-fluoran compounds of the present invention and Application Examples. EXAMPLE 1: 2-(2-Chlorobenzylamino)-6-di-n-butylamino-fluoran (Compound CB)3 To 832 g of 95% sulfuric acid, 93 g of 2-(2-hydroxy-4di-n-butylamino)benzoyl-benzoic acid was added and completely dissolved at a temperature of about 20 C, and then 55.5 g of 4-(2-chlorobenzylamino)-anisole was added and reacted therewith at a temperature of from 20 to 30 0C for 72 hours. After the reaction, the reaction mixture was poured into 2 liters of ice water and adjusted to a pH of 8.0 by an addition of a 10% sodium hydroxide aqueous solution, whereupon the precipitate was collected by filtration. To the cake thus obtained, 3 liters of toluene and 1.5 liters of a 10% sodium hydroxide aqueous solution were added, and the mixture was stirred for 2 hours under reflux. Then, the toluene layer was separated by liquid separation, washed with water and concentrated. The precipitated crystals were collected by filtration. The crystals were dried to obtain slightly pink 2-(2-chlorobenzylamino)-6-di-n-butylaminofluoran. This fluoran compound was recrystallized from methanol, whereby 100 g of crystals having a melting point of from 150 to 152 0C were obtained. This compound had Smax at 431 nm (molecular extinction coefficient max 11MEC1S: 1.75 x 104), at 452 nm (MEC: 1.67 x 104) and at 595 nm (MEC: 2.05 x 104) as measured in 95% acetic acid. A solution of this compound in toluene was colorless. When brought in contact with silica gel, the compound readily underwent color-development and turned greenish black. The 4-(2-chlorobenzylamino)-anisole used as the starting material in Example 1, was prepared in the following manner. Into 2.8 liters of methanol, 292 g of p-anisidine and 350 g of 2-chlorobenzaldehyde were dissolved and stirred for 2 hours under reflux. Then, the reaction mixture was cooled to 300C, and after an addition of 2.5 liters of methanol, 134 g of sodium borohydride was gradually added in 1 hour, whereby the formed Schiff base was reduced. After the addition, the reaction mixture was stirred for from I to 2 hours and then poured into 20 liters of water. The precipitated white crystals were dried to obtain 590 g of 4-(2-chlorobenzylamino)-anisole. This product had a melting point of from 53 to 540C. EXAMPLE 2: 2-(3-Chlorobenzylamino)-6-di-n-butylamino-fluoran Compound (C)1 In 832 g of 95% sulfuric acid, 2-(2-hydroxy-4-di- n-butylamino)benzoyl-benzoic acid and 65.5 g of 4-(3chlorobenzylamino)-anisole were reacted and treated in the same manner as in Example 1, whereby slightly pink crude crystals having a melting point of from 148 to 152 0C were obtained. The crude crystals were washed with ethanol, whereby 98 g of substantially colorless 2-(3chlorobenzylamino)-6-di-n-butylamino-fluoran having a melting point of from 151 to 152.50C was obtained. This compound had Amax at 432 nm (MEC: 1.67 x 104), at 454 nm (MEC: 1.59 x 104) and at 597 nm (MEC: 1.99 x 104) as measured in 95% acetic acid. A solution of this compound in toluene was colorless. When brought in contact with silica gel, the compound readily underwent color-develop- ment and turned greenish black. EXAMPLE 3: 2-(4-Chlorobenzylamino)-6-di-n-butylamino-fluoran [Compound (D)3 In 832 g of 95% sulfuric acid, 93 g of 2-(2-hydroxy 4-di-n-utylamino)benzoyl-benzoic acid and 65.5 g of 4-(4- chlorobenzylamino)-anisole were reacted and treated in the same manner as in Example 1, whereby slightly pink crude crystals having a melting point of from 130 to 1330C were obtained. The crude crystals were washed with methanol, whereby 101 g of substantially colorless 2-(4 chloroben zylamino) -6-di-n-butylamino-fluoran having a melting point of from 141 to 1430C was obtained. This compound had X at 432 nm (MEC: 1.64 x 104), at 453 nm max (MEC: 1.56 x 104) and at 596 nm (MEC: 1.92 x 104) as measured in 95% acetic acid. A solution of this compound in toluene was colorless. When brought in contact with silica gel, this compound readily underwent colordevelopment and turned greenish black. Application Example 1: To 2.0 g of Compound (B) prepared in Example 1, 20 g of water and 20 g of an aqueous solution containing 10% by weight of polyvinyl alcohol were added. The mixture was dispersed and mixed in a ball mill at room temperature for 24 hours to obtain a slurry wherein the particle size of the compound was about 3 pm. On the other hand, 7 g of bisphenol A was added to 10 g of water and 40 g of an aqueous solution containing 10% by weight of polyvinyl alcohol. The mixture was dispersed and mixed in a ball mill at room temperature for 24 hours to obtain a slurry. The solid substantace in this slurry had an average particle size of about 5 ijm. Both slurries were mixed, and the mixture was uniformly dispersed and mixed at room temperature for 1 hour, whereby a slurry mixture was prepared. This slurry mixture was coated on one surface of a normal paper of 50 g/m2 by means of a wire bar coater (wound wire: 0.35 mm in diameter) in an amount of the coated compound being 1.5 g/m2 of the paper. The coated paper was dried in air at room temperature, whereby a heat sensitive record sheet having a substantially colorless heat sensitive layer was obtained. This heat sensitive record sheet will be referred to as No. 1. In the same manner, heat sensitive record sheets No. 2 and No. 3 were prepared by using Compounds (C) and (D). Further, for the purpose of comparison, heat sensitive record sheets No. 4 to No. 8 were prepared in the same manner as above by using known 2-anilino-3methyl-6-diethylamino-fluoran [Compound (E)], 2 anilino-3-methyl-6-N-methyl-N-cyclohexyl2míno-fluoran Compound (F)1, 2-benzylamino-6-diethylamino-fluoran [Compound (A-l)1, 2-(2-chlorobenzylamino)-6diethylamino-fluoran [Compound (A-2)] and 2-(4-chlorobenzylamino)-6-diethylamino-f [Compound(A-3)]. These heat sensitive record sheets were subjected to the following tests. (1) Color-development performance test Heat sensitive record sheets No. 1 to No. 3 and comparative sheets No. 4 to No. 8 were heated at a temperature of 150 0C for 5 seconds, whereby the developed color hue, the developed color density and the initial color density were measured by means of Macbeth reflex densitometer RD-514 model with a visual filter (Wratten &num; 106). (2) Color-development characteristic test Heat sensitive record sheets No. 1 to No. 3 and comparative sheets No. 4 to No. 8 were heated for color-development within the temparature range of from 70 to 1600C for 5 seconds, whereby the color density at each temperature was measured in the same manner as in the above test (1), and the color-development initiation temperature and the rising for the color-development were calculated from the relationship between the temperature and the color density. (3) The resistance to self-color development under humidity Heat sensitive record sheets No.1 to No.3 and Comparative sheets No.4 to No.8 were kept at 500C for 24 hours under a relative humidity (RH) of 90%, and the color density was measured by means of Macbeth reflex densitometer R3-514 model with avisual filter (Wratten &num;106). The results of the above-mentioned color-development performance test (1), the results of the measurement of the color-development values (2) and the results of the measurement of the resistance to self-color development under humidity (3) are shown in the following Table. Table 2 Color-development performance and color-development characteristic values of heat sensitive record sheets EMI15.1 <SEP> Heat <SEP> sensitive <SEP> Color-development <SEP> Color-development <SEP> Resistance <SEP> to <SEP> self <SEP> record <SEP> sheet <SEP> performance <SEP> characteristic <SEP> color <SEP> development <tb> <SEP> Values <SEP> under <SEP> humidity <tb> <SEP> Developed <SEP> Developed <SEP> Color- <SEP> Rising <SEP> for <SEP> Self <SEP> Compound <SEP> Sheet <SEP> color <SEP> color <SEP> development <SEP> color- <SEP> Initial <SEP> developed <tb> <SEP> No. <SEP> No. <SEP> hue <SEP> density <SEP> initiation <SEP> developpement <SEP> color <SEP> color <tb> <SEP> temperautre <SEP> ( C) <SEP> density <SEP> density <tb> Present <SEP> B <SEP> 1 <SEP> Greenish <SEP> black <SEP> 1.15 <SEP> 92 <SEP> 4.4 <SEP> 0.07 <SEP> 0.25 <tb> invention <SEP> C <SEP> 2 <SEP> Greenish <SEP> black <SEP> 1.16 <SEP> 91 <SEP> 4.6 <SEP> 0.08 <SEP> 0.27 <tb> <SEP> D <SEP> 3 <SEP> Greenish <SEP> black <SEP> 1.18 <SEP> 88 <SEP> 5.3 <SEP> 0.08 <SEP> 0.28 <tb> Comparative <SEP> E <SEP> 4 <SEP> Reddish <SEP> black <SEP> 1.12 <SEP> 85 <SEP> 1.2 <SEP> 0.12 <SEP> 0.50 <tb> Examples <SEP> F <SEP> 5 <SEP> Reddish <SEP> black <SEP> 1.10 <SEP> 92 <SEP> 2.4 <SEP> 0.08 <SEP> 0.36 <tb> <SEP> A-1 <SEP> 6 <SEP> Greenish <SEP> black <SEP> 1.12 <SEP> 96 <SEP> 4.1 <SEP> 0.14 <SEP> 1.10 <tb> <SEP> A-2 <SEP> 7 <SEP> Greenish <SEP> black <SEP> 1.13 <SEP> 96 <SEP> 4.2 <SEP> 0.13 <SEP> 0.88 <tb> <SEP> A-3 <SEP> 8 <SEP> Greenish <SEP> black <SEP> 1.12 <SEP> 95 <SEP> 4.3 <SEP> 0.14 <SEP> 1.04 <tb> Note : The color development by heating was conducted by means of rhodiaceta model thermotest rhodiaceta (manufactured by French National Fiber Research Institute) at a heating temperature of from 70 to 160 C for a heating time of 5 aeconds under a load of 100 g/cmê. It is evident from the results shown in the above Table that the heat sensitive record sheets wherein the fluoran compounds of the present invention are used, are far superior in the color-development performance, the developed color characteristics and the resistance to self-color development under humidity to the comparative heat sensitive record sheets wherein comparative fluoran compounds are used. Thus, the industrial value for practical application of the present invention is considerably high.

Claims: CLAIMS: 1. A 2-(chloro-substituted benzylamino)-6-dibutylaminofluoran compound represented by the general formula: EMI17.1 2. The fluoran compound according to Claim 1, which is 2-(2-chlorobenzylamino)-6-di-n-butylamino-fluoran. 3. The fluoran compound according to Claim 1, which is 2-(3-chlorobenzylamino)-6-di-n-butylamino-fluoran. 4. The fluoran compound according to Claim 1, which is 2-C 4-chlorobenzylamino) -6-di-n-butylamino-fluoran.

Inventors: GONDA, MICHIHIRO, KANASUGI, MIKIKO, TAKEUCHI, SHUICHI
Applicants: HODOGAYA CHEMICAL CO., LTD.
Application year: 1984
Main classification: C07D493
IPC codes: C09B11, B41M5, C07D493