COSMETIC

Abstract: Silanised adsorbents may be used to reduce or prevent body odour.

Description: COSMETIC The present invention relates to a new use of silanised adsorbents and to deodorant compositions containing such adsorbents. Silanised silica gel is a known adsorbent and may be produced either by a) treating fine particles of silica gel with a reactive silane thereby replacing many of the hydroxy groups with substituted siloxy groups, or b) polymerising a suitable siloxane monomer in the presence of fine particles of silica gel thereby coating the particles with a polysiloxane. Reactive silanes useful in method (a) above include alkyl, aryl especially phenyl and aralkyl especially benzyl halosilanes and -silazanes and alkyl, aryl especially phenyl and aralkyl especially benzyl alkoxysilanes and -silazanes. Particular examples of such silanes include dimethyl monochlorosilane dimethyl dichlorosilane trimethylchlorosilane hexamethyl disilazane trichloro-octadecylsilane Suitable siloxane monomers for use in method (b) above include hydrogen polysiloxanes such as methyl hydrogen polysiloxane and alkyl, aryl and aralkyl cyclotetrasiloxanes, especially octamethylcyclotetrasiloxane. Polymerisation may be effected by heating or by chemical catalysis. Similar techniques may be applied to produce silanised alumina, calcium carbonate, hydroxyapatite, iron oxide, mica, talc and derivatives thereof including titanated mica and talc. Method (a) above is suitable for adsorbents with free hydroxyl groups and method (b) may be used on most finely divided solids to produce a silanised adsorbent. As used herein the term 'silanised adsorbents' refers to silanised silica gel, alumina, calcium carbonate, hydroxyapatite, iron oxide, mica and talc, and derivatives thereof. It has now been found that silanised adsorbents have particularly advantageous properties as adsorbents of the low molecular weight compounds considered to be the major components of body odour. Accordingly the present invention provides a method for reducing or preventing body odour which method comprises applying a silanised adsorbent to the body surface. Preferably the silanised adsorbent is silanised silica gel. Suitably the silanised silica gel is silanised silica gel having mean particle size of from 0.1 to 20 x 10'6m, the 'particles' being aggregates of very fine 'primary particles' of such small size. Preferably the silanised adsorbent is applied at least to the axillae, genital regions and/or the feet. Whilst the silanised adsorbent may be applied directly to the body, preferably it is applied in the form of a deodorant composition. Accordingly in another aspect the present invention provides a deodorant composition comprising a silanised adsorbent and an inert carrier or diluent there for. Suitably the composition may be presented in conventional deodorant form, for instance as a gel, roll-on formulation, cream, gel, lotion or stick, and will contain conventional carriers and diluents known to be suitable for each particular presentation. The composition may also comprise optional accessory ingredients such as antiperspirants, perfume, colouring and preserving agents, antibacterials and antimicrobial agents such as Irgasan and chlorhexidine. Preferably the compositions described above comprise from 0.1 to 5% w/w of silanised adsorbent, more preferably from 0.1 to 2%. Silanised adsorbents can be incorporated in non-aqueous media without difficulty. However to achieve homogeneity in products having an aqueous base it is advantageous, though not always essential, to include at least 2% w/w or a lower alkanol, such as isopropanol or, preferably, ethanol. More preferably the product contains from 10 to 50% w/w/ of an alkanol. The following Examples illustrate the invention but are not intended to limit the scope of the invention in any way. As used herein P.E.G. stands for polyethylene glycol. Example 1 High alcohol roll-on antiperspirant deodorant % w/w a) Ethanol 6Q.09 Hydroxypropylcellulose 0.66 Aluminium chlorhydrate (50% soln) 32 Irgasan DP 300 (Triclosan) 0.25 Myristic acid 1.5 Polyethylene glycol ether of lauryl alcohol 3.5 Silanised silica gel 2 100 b) Ethanol Hydroxypropylcellulose 0.66 Polypropylene glycol ether of myristyl alcohol 1.5 Aluminium Zirconium Tetrachlorohydrate 37.5 Silanised silica gel 2 100 Example 2 Quick Drying Emulsion Roll-on Antiperspirant Deodorant % w/w a) 92-3225C (emulsifier) 10.5 Silicone DC 344 (Cyclomethicone) 16.3 Aluminium chlorhydrate (50% active soln.) 38.2 Polyglyceryl-4 Oleate 1.5 De-ionised water 31.5 Silanised silica gel 2 100 b) Q2-3225C (emulsifier) 10.5 Polyglyceryl-4 Oleate 1.5 - Aluminium Zirconium Tetrachlorhydate/glycine complex 42.8 Deionised water 29 Silicone DC 344 (Cyclomethicone) 14.2 Silanised silica gel 2 100 Example 4 Stick antiperspirant Deodorants Suspension Type % w/w a) Stearyl alcohol 24 Mineral Oil 25 Silicone DC 345 (cyclomethicone) 17 Aluminium chlorhydrate (ultrafine) 25 Octyl Hydroxystearate 8 Silanised silica gel 1 190 b) Stearyl alcohol 25 Mineral Oil 28.5 Octyl Hydroxystearate 8 Silanised silica gel 0.5 Aluminium zirconium tetrachlorhydrate 20 Silicone DC 345 (cyclomethicone) 18 100 c) Alcohol type % w/w Ethanol 23 Silicone Doc 344 (cyclomethicone) 10 Talc 20 PEG-200 trihydroxystearin 5 Aluminium chlorhydrate (ultrafine) 20 Silanised silica gel 2 Stearyl alcohol 20 100 d) % w/w Ethanol 23 Silicone DC 344 (cyclomethicone) 10 Talc 20 PEG-200 Trihydroxy stearin 5 Aluminium zirconium tetrachlorhydrate 20 Silanised silica gel 2 Stearyl alcohol 20 100

Claims: Claims 1. A method for reducing or preventing body odour which method comprises applying a silanised adsorbent selected from silanised silica gel, alumina, calcium-carbonate, hydroxyapatite, iron oxide, mica, talc and derivatives thereof, to the body surface. 2. A method as claimed in claim 1 wherein the adsorbent is silanised silica gel. 3. A method as claimed in claim 1 wherein the silanised adsorbent is applied in the form of a deodorant composition. 4. A deodorant composition comprising a pilanised adsorbent as defined in claim 1 and an inert diluent or carrier therefor. 5. A composition as claimed in claim 4 wherein the silanised adsorbent is silanised silica gel. 6. A composition as claimed in claim 4 comprising at least 2% w/w of the total composition of ethanol. 7. Silanised adsorbent as defined in claim 1 for use in reducing or preventing body odour. 8. Use of a silanised adsorbent as defined in claim 1 for reducing or preventing body odour. 9. Use of a composition as defined in claim 4 for reducing or preventing body odour.

Inventors: FAIRHURST, EDGAR, KEYSER, ANNE MARION
Applicants: BEECHAM GROUP PLC
Application year: 1984
Main classification: A61K7
IPC codes: A61K8, A61Q15