PREPARATION OF 2-T-BUTYL-5-HYDROXYPYRIMIDINE BY HYDROLYSIS OF 2-T-BUTYL-5--BROMO/CHLOROPYRIMIDINE

Abstract: The hydrolysis of 2-t-butyl-5-halopyrimidines is carried out in the presence of an alkali metal methoxide and a catalytic amount of an N-oxide, a disulfide or elemental sulfur to prepare 2-t-butyl-5-hydroxypyrimidine in good yields and purity. The 2-t-butyl-5-chloropyrimidine which may be used can be made by the direct chlorination of 2-t-butylpyrimidine with elemental chlorine in an acetic or propionic acid solution at temperatures of 40° to 90°C in the presence of a buffer.

Description: PREPARATION OF 2-t-BUTYL-5-HYDROXYPYRIMIDINE BY mtDkOLYSI S OF 2-T-BUTYL-5-BROMO/CHLOROPYRIMIDINE In "The Pyrimidines", Interscience (1962), pages 203-204, it is stated that, "The conversion of an active halogeno intc an lydroxy group is rather uncommon, and not always eas". In Supplement I of "The pyrimidines", Interscience (1970), page.148, there is the statement, "The direct hydrolysis af a chloro- to an hydroxy-pyrimidine was avoided for many years, but no such inhibition seems to be operating now. Acid or alkali may be used, although the latter is more usual,...." Roweve:, attempts to hydrolyze 2-t-butyl-5-bromopyrimidine rich sodium methoxide gave considerable quantities of byproduct 2-t-butylpyrimidine. It has now been tounc that the hydrolysis of 2-t-butyl-5-halopyrimidines o prepare 2-t-butyl-5 -hydroxypyrimidine in g,opd yield; and purity may be carried out in the. presence of an alkali metal methoxide and a catalyic amount of an N-oxide, a disulfide or elemental sulfur. The reaction is advantageoisly carrie3 out at temperatures of from 100 to 300 C, preferably 150 to 2200C and most advantageously at 1600 to 1800C at ambient pressure in a Parr bomb, in the presence of from 0.5 to 20 mole percent of catalyst. The preferred catalyst is elemental sulfur and it is preferably employed in an amount of from 2.5 to 7.5 mole percent. Sodium methoxide is preferably employed, although other alkali metal methoxides such as potassium methoxide may be employed, if desired. The hydrolysis is advantageously and preferably carried out in a methyl alcohol solvent. The invention is further illustrated by the following Examples, wherein 2-t-butyl-5-bromopyrimidine was hydrolyzed in the presence of sodium methoxide in excess methanol in a Parr bomb. The following products were obtained: A. 2 -t-butylpyrimidine B. 2-t-butyl-5-methoxypyrimidine, C. 2-t-butyl-5-hydroxypyrimidine Mole Temp. Products Run Catalyst ¯¯¯¯ OC A B C 1 None 0 150 23 11 77 2 None 0 150 37 11 58 3 2-Picoline- 10 152 12 12 69 -n-oxide 4 2-Picoline- ! 24 152 12 1 76 --n-oxide 5 Di-n-butyl 5 160 12 1 91 -disulfide 6 Di-n-butyl- 10 160 7 1 105 -disulfide 7 So 5 163 4 12 88 8 S 5 165 5 1 94 Mole Temp. Products. Run Catalyst % C A B C 9 so 2.5 153 7 15 80 10 S 7.5 156 4 11 S 5 155 8 w 4 93 12 S 2.5 155 7 2 93 13 S 1.5 160 10.14 . - 101.41 14 S 0.5 160 12.06. . - 97.55 15* So 2.5 170 4 ..- 100 *Hydrolysis of 2 -t-butyl-5-chloropyrimidine. It has further been found that 2-t-butyl-5 -chloropyrimidine may be made in good yields and purity by the direct chlorination of 2-t-butylpyrimidine with elemental chlorine in an acetic or propionic acid solution at temperatures of 00 to 900C, and preferably in the presence of a buffer. The 2-t-butyl-5-chloropyrimidine is advantageously employed as an intermediate in the preparation of O-alkyl-o-[pyrimidin(5)yl]-(thiono) (thiol)-phosphoric (phosphonic) acid esters or ester amides having exceptional insecticidal activity by the processes described in U.S. Patent 4,127,652. The chlorination of 2-t-butylpyrimidine is preferably carried out at temperatures of 550 to 650C and in the absence of a catalyst. The solution of 2-t-butylpyrimidine preferably contains from 1.5 to 3.0 moles pyrimidine per liter of solvent, although higher or lower amounts may be employed if desired. In more dilute solutions, greater energy requirements must be met in order to separate the desired product and chlorination of the solvent itself is more apt to take place. In more concentrated solutions, it is more difficult to maintain a uniform mixture or solution because of increased viscosity. Suitable buffers include, for example, sodium acetate, potassium acetate, sodium propionate and potassium-propionate. It is desirable that the buffer be soluble in the solvent. Sodium acetate is preferred. The preferred solvent is acetic acid. The chlorination reaction is further illustrated by the following examples where all parts are by weight unless otherwise specified. t-Butylpyri midine Acetic Acid Sodium Acetate Temperature Run (moles) ( ml ) (Moles) ( C) Time, hrs Tield 1 0.022 25 0.026 60 4.5 97 2 0.367 250 0.44 60 6.0 75 3 0.734 500 0.88 60 6.0 86 4 0.734 500 0.88 60 6.0 97 5 0.734 500 0.88 60 6.0 73 6 0.1 68 0.12 60 3.5 83 7 1.47 500 1.78 60 13.0 79 8 1.47 500 1.76 60 10.5 82 Similar results may be obtained when employing propionic acid as the solvent and/or utilizing other buffers such as, for example, potassium acetate, sodium propionate and potassium propionate.

Claims: @@@@ A method of making 2-t-butyl-5-hydroxy- pyrimidine which comprises hydrolyzing a 2-t-butyl -5-halopyrimidine in the presence of an alkali metal methoxide and a catalyst comprising an n-oxide, a disulfide or elemental sulfur. 2. Method of Claim 1 wherein the halopyrimidine is 2-t-butyl-5-bromopyrimidine. 3. Method of Claim 2 wherein the reaction is carried out at 1500 to 2200C. 4. Method of Claim 2 wherein the catalyst is 2-picoline-n-oxide, di-n-butyldisulfide or elemental sulfur. 5. Method of Claim 1 wherein the halopyri midine is 2-t-butyl-5-'chloropyrimidine. 6. Method of Claim 5 wherein the 2-t-butyl -5-chloropyrimidine is prepared by chlorinating 2-t-butylpyrimidine in acetic or prop ironic acid solution with elemental chlorine in the absence of a catalyst at temperatures of from 400 to 900C. 7. Method of Claim 6 wherein the reaction temperature is from 55 to 650C. 8. Method of Claim 7 wherein the reaction is carried out for from 3 to 15 hours. 9. Method of Claim 6 wherein the solvent is buffered with sodium acetate. 10. Method of Claim 9 wherein t.le solvent is acetic acid.

Inventors: PEWS, RICHARD GARTH
Applicants: THE DOW CHEMICAL COMPANY
Application year: 1983
Main classification: C07D239
IPC codes: C07D239