BIPHENYLYLPROPIONIC ACID DERIVATIVE, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Abstract: Biphenylylpropionic acid derivatives of the formula: wherein R is an alkylcarbonyloxyalkyl group or an alkenylcar­ bonyloxyalkyl group having the formula: --(CH₂) m - OR² wherein R¹ is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R² is an alkyl group having 1 to 15 carbon at­ oms or an alkenyl group having 2 to 8 carbon atoms, and m is 0 or an integer of 1 provided that when R¹ is a lower alkyl group, m is 0, or a lactone having the formula: wherein R³ and R⁴ are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irrita­ tion, rapid and long acting and high safety margin.

Description: BIPHENYLYLPROPIONIC ACID DERIVATIVE, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME The present invention relates to novel biphenylylpropionic acid ester derivatives. More particularly, the present invention relates to biphenylylpropionic acid ester derivatives having the formula (I): EMI1.1 wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (II): EMI1.2 wherein R1 is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R2 is an alkyl group,having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, and m is O or an integer of 1, provided that when R is a lower alkyl group, m is 0, or a lactone having the formula (III): : EMI1.3 wherein R3 and R4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2, a process for preparing the same and a pharmaceutical composition containing the same as an effective ingredient. It is known that 2-(2-fluoro-4-biphenylyl)propionic acid (hereinafter referred to as "FP") has strong anti-inflammatory, analgesic and antipyretic activities. However, the formulation form of FP is limited in the form of injection, syrup, or an external preparation such as ophthalmic agent, suppository, cream or plaster because of its irritation. Thus, various modifications are required for a pharmaceutical preparation of FP and the preparation is difficult. As a result of various studies, the present inventors have now found that a satisfactory drug which has no irritation, an excellent pharmacological effect being several times higher than that of FP and less side effects. That is, the compound (I) of the present invention prepared from FP by esterifying has no irritation. Moreover, the compound (I) is excellent in absorption from mucosa or skin because of its high hydrophobic property. Thus, the pharmacological effect of the compound (I) is quickly appeared and increased. On the other hand, when the compound (I) is formulated in combination with an oleaginous base, the pharmacological effect of the compound (I) is increased and prolonged, and the bioavailability of the compound (I) is increased. Further, the compound (I) is hard to bind with plasma proteins because of its physicochemical properties such as no free polar group and oil. As a result, the tissue distribution and metabolism of the compound (I) after administration are different from those of FP. Accordingly, the concentration of the compound (I) at an inflammatory site is increased to show excellent pharmacological effects. Though a substained-release agent is generally utilized in order to prolpng a pharmacological effect, the compound (I) of the present invention gains a prolongation of a pharmacological effect by advantageously utilizing reaction of metabolic enzyme. More particularly, since the compound (I) in which RÚ is a lower alkyl group or R is a lactone having the formula (III) is consisted of di as tereomers having two asymmetric carbon atoms in a molecular, there shows a difference of hydrolyzing rate among the diastereomers when the compound (I) is hydrolyzed by metabolic enzymes in tissues. In case of measuring by gas chromatography, for instance, there shows about 5-fold difference in the hydrolyzing rate in plasma. Thus, FP being a parent material of the compound (I) as a physiologically active form is slowly and complementarily relesed in tissues to prolong an effective blood concentration of FP. Therefore, the compound (I) is excellent as a drug having no irritation, excellent pharmacological effects, rapid and long-acting, and large safety margin. It is an object of the present invention to provide novel FP ester derivatives which are useful and characteristic pro-drugs utilizing advantageously enzyme reactions and having excellent anti-inflammatory, analgesic and antipyretic activities, less side effects and high safety. A further object of the invention is to provide a process for preparing FP ester derivatives. Another object of the invention is to provide a pharmaceutical composition containing FP ester derivatives as effective ingredients. These and other objects of the invention will become apparent from the description hereinafter. In accordance with the present invention, there can be provided a FP ester derivative having the formula (I): EMI3.1 wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (II): EMI3.2 wherein R1 is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, and m is 0 or an integer of 1, provided that, when R is a lower alkyl group, m is 0, or a lactone having the formula (III): EMI4.1 wherein R3 and R4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The preferable substituent group defined as R in the formula (I) is acetoxymethyl, propionyloxymethyl, isobutyryloxymethyl, pivaloyloxymethyl, palmitoyloxymethyl, crotonoyloxymethyl, 3,3-dimethylacryloyloxymethyl, l-acetoxyethyl, l-acetoxypropyl, l-propionyloxyethyl, l-isobutyryloxyethyl, l-pivaloyloxyethyl, l-palmitoyloxyethyl, l-crotonoyloxyethyl, l-(3,3-dimethylacryloyloxy)ethyl, l-( 2, 4-hexadienoyloxy)ethyl, 2-acetoxyethyl, 2-propionyloxyethyl, 2-crotonoyloxyethyl, 2-(3,3-dimethylacryloyloxy)ethyl, 2-(2,4-hexadienoyloxy)ethyl, 2-(3,7-dimethyl-2,6-octadienoyloxy)ethyl or 3,3-dimethyl t-butyrolactone-2-yl group. Representative compounds among the FP derivatives (I) are as follows: Compound 1: acetoxymethyl 2-(2-fluoro-4-biphenylyl) No. propionate n 2: propionyloxymethyl 2-(2-fluoro-4-biphenylyl) propionate 3: isobutyryloxymethyl 2-(2-fluoro-4 biphenylyl)propionate 4: crotonoyloxymethyl 2-(2-fluoro-4-biphenylyl) propionate 5: 3,3-dimethyl-acryloyloxymethyl 2-(2-fluoro 4-biphenylyl)propionate 6: palmitoyloxymethyl 2-(2-fluoro-4-biphenylyl) propionate 7: pivaloyloxymethyl 2-(2-fluoro-4-biphenylyl) propionate Compound 8: l-(acetoxy)ethyl 2-(2-fluoro-4-biphenylyl) No. propionate 9: 1-(propionyloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate 10: l-(isobutyryloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate 11: l-(pivaloyloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate 12: l-(palmitoyloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate 13: 1-(acetoxy)propyl 2-(2-fluoro-4-biphenylyl) propionate 14: 1-(crotonoyloxy)ethyl 2-92-fluoro-4 biphenylyl)propionate 15: [l-(3,3-dimethylacryloyloxy)ethyl] 2-(2 fluoro-4-biphenylyl)propionate 16: [l-(2,4-hexadienoyloxy)ethyl] 2-(2-fluoro 4-biphenylyl)propionate 17: 2-(acetoxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate 18: 2-(propionyloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate 19: 2-(crotonoyloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate " 20: 2-(3,3-dimethylacryloyloxy)ethyl 2-(2- fluoro4-biphenylyl)propionate 21: 2-(2,4-hexadienoyloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate 22: 2-(3,7-dimethyl-2,6-octadienoyloxy)ethyl 2 (2-fluoro-4-biphenylyl)propionate 23: 3,3-dimethyl-2-[2-(2-fluoro-4-biphenylyl) propionyloxy]-&gamma;-butyrolactone The FP derivatives (I) of the present invention are prepared by reacting FP or the salt thereof having the formula (IV): EMI6.1 wherein Y is hydrogen atom or a metal salt, with a compound having the formula (V): EMI6.2 wherein R1 R2 and m are as defined above and X is a halogen atom, or a compound having the formula (VI): EMI6.3 wherein R3, R4 and n are as defined above. The FP derivatives having the formula EMI6.4 wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (IIo): EMI6.5 wherein R2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, are also prepared by reaction 2-hydroxyethyl ester of FP having the formula (VII): EMI6.6 with an acid anhydride having the formula (VIII): EMI7.1 wherein R is a lower alkyl group having 1 to 2 carbon atoms or an alkenyl group having 2 to 7 carbon atoms, or by reacting a 2-haloethyl ester FP having the formula (IX): EMI7.2 wherein X is a as defined above, with a compound having the formula (X): R5COOH (X) wherein R is as defined above. Though the above reactions can be conducted by employing any conventional esterifying reaction, the following method is preferred in point of yield and industrial production. That is, the esterifying reactions between FP or the salt thereof having the formula (IV) and the compound (V), and the compound (IX) and the compound (X) are generally carried out in an aprotic solvent such as N,N-dimethylformamide, dimethylsulfoxide or hexamethylsulfonyltriamide, or an organic solvent such as acetonitrile, dichloromethane, dichloroethane, chloroform, benzene, ether or tetrahydrofuran, in the presence or absence of an alkali metal carbonate such as sodium carbonate, potassium carbonate, sodium bicarbonate or potassium bicarbonate, an alkali hydroxide such as sodium hydroxide or potassium hydroxide, an alkali metal hydride such as sodium hydride, potassium hydride or lithium hydride, an organic base such as pyridine, triethylamine, N,N-dimethylaniline or tetramethylethylenediamine, an alkali metal iodide such as sodium iodide or potassium iodide, or a phase transfer catalyst such as a crown ether, e.g. 15-crown-5 or 18-crown-6, [2,2,2]-cryptand or [2,2,21 -benzocryptand. Examples of the salt of the compound (IV) employed in the above reaction are, for instance, metal salts such as silver and copper salt, alkali metal salts such as lithium, sodium and potassium salts. The above-mentioned aprotic solvents may be also employed in combination with ether, tetrahydrofuran, benzene, chloroform, dichloromethane, dichloroethane or acetone. On the other hand, the esterifying reaction between a FP derivative (IV) and an alcohol derivative (VI) is carried out by dehydration condensation in an organic solvent, under neutral condition and in the absence or presence of a catalyst or a dehydrating agent. Suitable examples of the organic solvent employed in the above reaction are, for instance, dichloromethane, chlorofdrm, ether, benzene, tetrahydrofuran, and the like. Examples of the dehydrating agent employed in the above reaction are, for instance, N,N-dicyclohexylcarbodiimide, l-ethyl-3( 3- dimethylaminopropyl)carbodiimide (water soluble carbodiimide), their hydrochlorides, and the like. Examples of the catalyst employed in the above reaction are, for instance, pyridine, halogenopyridine, tributylamine, aminopyridine, p-dimethylaminopyridine, and the like. The use of p-dimethylaminopyridine produces a particularly high yield. As one of the applications of an active esterifying reaction, the desired compound (I) may be prepared by reacting an imidazoate obtained by reacting a FP derivative (IV) with carbonyldiimidazole, with the above alcohol derivative (VI). The desired compound (I) may be also prepared in a high yield by dehydration condensation conducted by using triphenylphosphin or triethyl phosfite and azodicarboxylic acid dialkyl ester. The amounts of the compounds (V) or (VI), (VIII) and (X) to be used in the above reactions are usually employed in an amount not less than 1.0 mole, preferably 1.0 to 1.5 moles, per mole of the compounds (IV), (VIII) and (IX), respectively. The reaction temperature is not particularly limited, but the reaction is usually carried out at a temperature of 0 to 120 0C. Though the reaction time is varied depending on the reaction conditions such as kinds of solvent or catalyst and temperature, the reaction is usually carried out for several minutes to more than ten hours. The FP derivatives (I) of the present invention have excellent anti-inflammatory, analgesic and antipyretic activities, and also a high degree of biological hydrolysis. Particularly, l-(acetoxy)ethyl 2 (2-fluoro-4-biphenylyl)propionate, l-(propionyloxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate, l-(crotonoyloxy)ethyl 2(2-fluoro-4-biphenylyl)propionate and 3, 3-dimethyl 2-[ 2-( 2-fluoro-4-biphenylyl )propionyloxyi -'T-butyrolactone show excellent pharmaceutical effects. Accordingly, the FP derivatives (I) are very useful as anti-inflammatory, analgesic, antipyretic and anti-rheumatoid agents. They can be formulated in a usual manner into compositions in the form of tablet, capsule, suppository and cream with conventional pharmaceutical carriers. Any conventional carriers used in preparations can be employed in the present invention. Examples of the carrier are, for instance, excipients, binders, lubricants, coloring agents, sterilized water, plant oil, harmless organic solvent, perfumes, emulsifying sgents, dispersing agents, and the like. With respect to the representative compounds of the present invention(the above-mentioned Compound Nos. 1 to 23), the values of ED50 (50 % effective dose) orally or intravenously in rats by a carrageenan-induced edema inhibitory test, UD50 (50 % ulcerative dose) orally in rats by a gastric irritation test, hydrolyzing rate in human plasma and LD50 (50 % lethal dose) orally in mice are shown in Table 1. Table 1 ED50 Compound mg./kg. UD50 Hydrolyzing LD50 No. mg./kg. rate (%) mg./kg. p.o. i.v. 1 0.5 0.08 3.6 97.5 880 2 0.5 0.07 2.5 94.6 750 3 0.6 0.10 2.0 86.3 600 4 0.6 0.08 2.0 81.4 600 5 0.5 0.06 2.0 64.8 900 6 1.5 0.50 5.0 3.8 > 1000 7 0.6 0.10 2.5 70.3 840 8 0.5 0.05 2.5 70.7 650 Compounds 9 0.7 0.06 3.0 56.3 800 of the 10 1.5 0.1 5.0 35.2 880 invention 11 2.5 0.6 10.0 8.3 > 1000 12 > 5.0 > 5.0 > 10.0 2.0 > 1000 13 1.5 5.0 36.0 900 14 0.9 4.0 42.0 800 15 2.5 7.0 19.8 1000 16 2.0 7.0 20.4 1000 17 0.7 2.0 100.9* 650 18 0.7 2.0 98.9* 700 - continued - - continued ED50 Compound mg./kg. UD50 Hydrolyzing LD50 No. mg./kg. rate (%) mg./kg. p.o. i.v. 19 0.9 - 3.0 99.5* 800 Compounds 20 1.0 - 3.0 99.8* 880 of the 21 0.9 - 3.0 100.3* 750 invention 22 0.9 - 3.0 101.0* 750 23 0.5 0.05 2.5 72.3* 670 Comparative acemethacin 8.3 - 17.5 4.2 18.0 compounds indomethacin 5.5 1.25 5.0 - 14.0 FP 0.8 0.3 1.0 - 440 * values in rat plasma As is clear from Table 1, the compounds (I) of the present invention have excellent pharmacological effects in comparison with the comparative compounds such as acemethacin, indomethacin and FP. For example, the inhibitory effect on carrageenan-induced edema of the compound (I) is about 8 times that of indomethacin and the same as that of FP. Especially, in the case of intravenously administration, the activity of Compound No. 8 is about 6 times that of FP and about 25 times that of indomethacin. With respect to ulceration which is one of the main side effects of anti-inflammatory agents, the ulceration with the compound (I) is about one third that of FP. LD50 of the compound (I) is 1.5 to 2.0 times higher than that of FP. Thus, the acute toxicity of the compound (I) is considerably reduced. Furthermore, the safety margin of the compound (I) expressed by a ratio of UD50 to ED50 is about 3 times broader than that of FP. The effective dose of the compound (I) is about 20 to about 700 mg./day to adult. The present invention is more particularly described and explained by means of the following Examples, in which all % are by weight unless otherwise noted. In order to illustrate the preparation of (l-chloroethyl )c)rotonate, (l-chloroethyl)-3,3-dimethylacrylate, (1-chloroethyl )-2, 4-hexadienoate, (2-hydroxy yethyl)-2-(2-fluoro-4-biphenylyl)propionate and (2-bromoethyl) 2-(2-fluoro-4-biphenylyl)propionate employed as starting materials for preparing the FP derivatives (I) of the invention, the following Reference Examples are also presented. Reference Example 1 [(l-Chloroethyl )crotonate] Into a reaction vessel were added 4.8 g. of paraldehyde and 0.14 g. of 96 % zinc chloride. To the resulting mixture was added dropwise 10.5 g. (0.1 mole) of crotonoyl chloride with ice-cooling, and then the reaction mixture was reacted with stirring at a room temperature for 2 hours. The resulting reaction mixture was poured into cold water and extracted with 100 ml of ether. The obtained extract was washed successively with a saturated sodium hydrogencarbonate solution and two portions of a saturated sodium chloride solution. After drying the organic layer with anhydrous magnesium sulfate, the solvent was distilled away under reduced pressure to give a yellow liquor. The product was further distilled under reduced pressure (bp: 87 to 880C./37 mmHg) in an atmosphere of nitrogen gas to give 8.44 g. (yield: 56.8 %) of the desired compound being a clear solution. GC-MS (20 eV)m/e: 148(M+), 150(M+2), 113, 86, 69(base peak), 41 and 27 Reference Example 2 [(l-Chloroethyl )-3 , 3-dimethylacrylate] The procedure of Reference Example I was repeated except that 6.8 g of paraldehyde, 0.2 g (2 mmoles) of 96 % zinc chloride and 18.5 g (0.156 mole) of 3,3-dimethylacryloyl chloride were employed, to give 21.54 g. (yield: 85 %) of the desired compound being a clear solutoin. Boiling point: 860 to 870C./24 mmHg GC-MS (20 eV) m/e: 162 (M+), 164 (M+2), 126, 100, 83 (base peak), 63, 55 and 29 Reference Example 3 [(l-Chloroethyl)-2,4-hexadienoate] A mixture of 5.6 g. (50 mmoles) of sorbic acid and 7.8 g. (65 mmoles) of thionyl chloride was stirred at a room temperature for one hour, and then reacted at 50 C. for 30 minutes with stirring to complete the reaction. The end point of the reaction was judged by cessation of SO2 gas production and disappearance (dissolution) of sorbic acid. The resulting reaction mixture was cooled with ice, and then 0.27 g. (2 mmoles) of 96 % zinc chloride was added thereto. After adding dropwise 2.2 g. of paraldehyde at 0 C., the reaction was carried out at a room temperature for one hour. The resulting reaction mixture was treated and purified in the same manner as in Reference Example 1 to give 5.43 g. (yield: 64.2 %) of the desired compound being a clear solution. Boiling point: 1110 to 1120C./18 mmHg GC-MS (20 eV) m/e: 175 (M+), 176 (M+2), 111, 97, 95(base peak), 67 and 41 Reference Example 4 [(2-Hydroxyethyl) 2-(2-fluoro-4-biphenylyl)propionate] In 45 ml. of anhydrous dimethylformamide (hereinafter referred to as "DMF") was dissolved 12.2 g. (50 mmoles) of FP. To the resulting solution was added 6.9 g. (50 mmoles) of anhydrous potassium carbonate. After adding dropwise 6.25 g. (50 mmoles) of ethylene bromohydrin with ice-cooling, the reaction was carried out at 600 to 70 C. for 15 hours with stirring. After cooling the reaction mixture with ice, the resulting inorganic material was filtered off, and then the solvent was distilled away under reduced pressure. To the resulting residue was added 50 ml. of diethyl ether, and then the resulting mixture was washed successively with water, 10 % solium carbonate solution and a saturated sodium chloride solution, and the organic lawer was dried with magnesium sulfate. The solvnet was distilled away under reduced pressure to give 13.8 g. of clear oily material. The resulting oily material was further purified by chromatography of silica gel (Kiesel gel 60 F made by Merck & Co., Inc.; Developing solvnet: (1) dichloromethane (2) dichloromethane : ether = 9 : 1 (3) dichloromethane ether = 8 : 2) to give 9.97 g. (yield: 69.2 %) of white crystal of the desired compound having a melting point of 73 to 75 C. Mass spectrum (20 eV, Direct) m/e: 288 (M+), 244, 199 (base peak), 184, 178 and 45 Reference Example 5 [(2-Bromoethyl) 2-(2-fluoro-4-biphenylyl)propionate] In 40 ml. of dichloromethane was dissolved 12.2 g. (50 mmoles) of FP. To the resulting solution were added 6.25 g. (50 mmoles) of ethylene bromohydrin and 0.3 g. (2.5 mmoles) of p-dimethylaminopyridine. After adding dropwise 10.3 g. (50 mmoles) of dicyclohexylcarbodiimide dissolved in dichloromethane, the reaction was carried out at a room temperature for 30 minutes with stirring. After cooling the reaction mixture with ice, the insoluble material was filtered off, and then the organic layer was washed successively with 0.1 N hydrochloride, saturated sodium hydrogencarbonate solution and saturated sodium chloride solution, and dried with anhydrous magnesium sulfate. After distilling away the solvent under reduced pressure, the precipitated dicyclohexylurea was filtered off. The resulting yellowish oily material was purified in the same manner as in Reference Example 4 to give 15.6 g. (yield: 89 %) of the desired compound being a clear oily material. Mass spectrum (20 eV, Direct) m/e: 351 (M+), 353 (M+2), 244, 199 (base peak), 184, 178, 108 and 110 Example 1 [Acetoxymethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 1)] In 100 ml. of anhydrous DMF was dissolved 7.32 g. (30 mmoles) of PP. To the resulting solution was added 2.1 g. (15 mmoles) of anhydrous potassium carbonate with ice-cooling, and then the resulting mixture was stirred for one hour. After adding dropwise 3.3 g. (30 mmoles) of acetoxymethyl chloride purified by distillation at 0 to 5 C. for 10 minutes, the reaction was carried out with stirring at a room temperature for 2 hours. After cooling the resulting reaction mixture with ice and filtering off the inorganic materials, the solvent was distilled away under reduced pressure. To the obtained residue was added 150 ml. of diethyl ether, and then the residue was washed successively with water, 10 % of sodium carbonate solution and a saturated sodium chloride solution. The obtained organic layer was dried with anhydrous magnesium sulfate, and then the solvent was distilled away under reduced pressure to give 8.24 g. (yield: 86.9 %) of the desired compound being an oily material. The product was further distilled under reduced pressure in an atmosphere of nitrogen gas to give 6.55 g. (yield: 69.1 %) of an oily material having a boiling point of 1950 to 1970C./0.4 mmHg. Elementary analysis for C18H17C4F (MW: 316): Calcd.(%): C 68.35 H 5.38 Found (%): C 68.42 H 5.51 Nuclear magnetic resonance spectrum (in CC14, TMS), #(ppm): 1.49 (d, 3H, #CH-CH@), 2,00 (s, 3H, -OCO-CH3), 3,74 (q, 1H, CH3-CH ), 5.71 (s, 2H, 7.03 to 7.56 (m, 8H, aromatic H) Mass spectrum (20 eV, Direct ) m/e: 316 (Mt), 226 ([M-OCH2OAc] ), 199 (base peak, [M-CO2CH2OAc] 4:-), 73 [-CH2oAc] + and 43 [-CoCH3] + Infrared absorption spectrum (v cmT1): : 3100 to 2850 (aromatic, alkyl v C-H), 1760 (v COOR), 1625 to 1420 (aromatic, v C=C) and 1370 (v-COCH3) Refractive index: n26=1.5488 Ultraviolet absorption: max = 248 nm. Example 2 [Propionyloxymethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 2)] In 100 ml. of anhydrous DMF was dissolved 7.32 g. (30 mmoles) of FP. To the resulting solution was added 2.1 g. (15 mmoles) of anhydrous potassium carbonate with ice-cooling, and then the reaction mixture was stirred for one hour. After adding dropwise 4.78 g. (39 mmoles) of propionyloxymethyl chloride purified by distillation with ice-cooling, the reaction was carried out with stirring at a room temperature for 2 hours, and then at 600 to 700C. for one hour. After completion of the reaction, the reaction mixture was cooled, and then the inorganic material was filtered off. After distilling away the solvent under reduced pressure, 150 ml. of dimethyl ether was added to the residue, and then the organic layer was washed successively with water, 10 % sodium carbonate solution and a saturated sodium chloride solution. After drying the obtained organic layer with anhydrous magnesium sulfate, the solvent was distilled away under reduced pressure. The resulting product was further distilled under reduced pressure in an atmosphere of nitrogen gas to give 7.35 g. (yield: 74.2 %) of the desired compound being a colorless oily material having a boiling point of 1950 to 1960C./0.8 mmHg. Elementary analysis for ClgH1904F (MW: 330): Calcd.(%): C 69.09 H 5.76 Found (%): C 69.33 H 5.98 Nuclear magnetic resonane spectrum (in CC14, TMS), #(ppm): 1.08 (t, 3H, -CH2-CH3), 1.52 (d, 3H, CH3-CH ), 2.26 (q, 2H, -CH2-CH3), 3.72(q, 1H, CH3-CH ), 5.69 (s, 2H, -O-CH2-O-) and 7.06 to 7.55 (m, 8H, aromatic H) Mass spectrum (20 eV, Diret) m/e: EMI18.1 Infrared absorption spectrum ( > cm.l): 3100 to 2850 (aromatic, alkyluCH), 1760 (v R-COO-R) and 1625 to 1420 (aromatic vC=C) Refractive index: nD26 = 1.5431 Ultraviolet absorption: Amax = 248 nm. Example 3 [Isobutyryloxymethyl 2-(2-fluoro-4-biphenylyl)propionate compound No. 3)] The procedure of Example 2 was repeated except that 4.08 g. (30 mmoles) of isobutylyloxymethyl chloride was employed instead of propionyloxymethyl chloride, to give 7.29 g. (yield: 70.6 %) of the desired compound being an oily material having a boiling point of 1880 to l900C./0.4 mmHg. Elementary analysis for C20H21O4F (MW: 344) Calcd.(%): C69.77 H 6.10 Found (%): C70.03 H 6.08 Nuclear magnetic resonance spectrum (in CC14, TMS), Cppm): 0.98 to 1.20 (m, 6H, EMI19.1 1.50 (d, 3H, EMI19.2 2.46 (m, 1H, EMI19.3 3.72 (q, 1H, CH3-CH ), 5.69 (s, 2H, -O-CH2-O-) and 7.00 to 7.60 (m, 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: EMI19.4 43 ([-CH(CH3)2]+) Infrared absorption spectrum ( v cm. ): 3100 to 2850 (aromatic, alkyl C-H), 1755 (uCOO-R) and 1625 to 1420 (aromaticv C=C) Refractive index: nD26 = 1.5409 Example 4 [Crotonoyloxymethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 4)] The procedure of Example 2 was repeated except that 4 g. (30 m moles) of crotonoyloxymethyl chloride instead of propionyloxymethyl chloride was employed, to give 5.57 g. (yield: 54.3 %) of the desired compound being an oily material having a boiling point of 2170 to 2190C./0.4 mmHg. Elementary analysis for C C20H1904F (MW: 342) Calcd.(%): C70.18 H 5.55 Found (%): C70.46 H 5.79 Nuclear magnetic resonance spectrum (in CC14, TMS), ;Cppm): 1.52 (d, 3H, EMI20.1 1.68 to 1.95 (m, 3H, olefinic CH3 ), 3.73 (q, 1H, EMI20.2 5.67 to 5.94 (m, 1H, olefinic H), 5.75 (s, 2H, -O-CH2-O-), 6.80 to 6.98 (m, 1H, olefinic H) and 7.00 to 7.52 (m, 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: EMI20.3 Ultraviolet absorption: A max = 248 nm. Example 5 [3,3-Dimethylacryloyloxymethyl 2-(2-fluoro-4-biphenylyl) propionate (Compound No. 5)] The procedure of Example 2 was repeated except that 5.8 g. (39 mmoles) of 3,3-dimethylacryloyloxymethyl chloride instead of propionyloxymethyl chloride was employed, to give 6.57 g. (yield: 61.5%) of the desired compound being an oily material having a boiling point of 2100 to 214 C./0.5 mmHg . Elementary analysis for C21H21O4F z F (MW: 356): Calcd.(%): C70.79 H 5.90 Found (%): C71.12 H 6.25 Nuclear magnetic resonance spectrum (in CCl4, TMS), d(ppm): 1.52 (d, 3H, CH3-CH), 1.94 (s, 3H, olefinic CH3), 2.10 (s, 3H, olefinic CH3), 3.70 (q, 1H, CH3-CH ), 5.55 to 5.69 (m, 1H, olefinic H), 5.72 (s, 2H, -O-CH2-O-) and 7.00 to 7.51 (m, 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: EMI21.1 Infrared absorption spectrum (v cm.-1): 3100 to 2850 (aromatic, alkyl v C-H), 1745 ( y COO-R), 1645 (olefinic EMI21.2 and 1625 to 1420 (aromatic v C = C) Refractive index: nD26 = 1.5535 Example 6 [Palmitoyloxymethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 6)] The procedure of Example 2 was repeated except that an ether solution of 11.9 g. (39 mmoles) of palmitoyloxymethyl chloride instead of propionyloxymethyl chloride was employed, to give 9.7 g. (yield: 73.1 %) of white crystals of the crude desired compound. The resulting product was purified by centrifugal liquid chromatography (carrier: KT 2106 made by Fuji gel Co., Ltd.; Eluent: cyclohexane : dichloromethane = 1 : 1) to give 7.3 g. (yield: 47.5 %) of white crystals of the desired compound having a melting point of 45.5 to 480C. Elementary analysis for C32H4504F (MW: 512): Calcd.(%): C 75.0 H 8.79 Found (%): C 75.34 H 9.04 Nuclear magnetic resonance spectrum (in CC14, TMS), # (ppm): 0.88 (t, 3H, -CH2-CH3), 1.11 to 1.42 (m, 26H, alkyl H), 1.51 (d, 3H, CH3-CHs ), 2.23 (t, 2H, -OCO-CH2-CH2-), 3.71 (q, 1H, CH3-CH#), 5.65 (s, 2H, -O-CH2-O-) and 7.00 to 7.67 Cm, 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: : EMI22.1 3100 to 2800 (aromatic, alkyl ii C-H), 1755 (vR COO-R) and 1625 to 1420 (aromatic V C=C) Example 7 [Pivaloyloxymethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 7)] The procedure of Example 2 was repeated except that 4.51 g. (30 mmoles) of pivaloyloxymethyl chloride instead of propionyloxymethyl chloride was employed to give 7.73 g. (yield: 72.0 %) of the desired compound being an oily material having a boiling point of 191 to 194 C./0.4 mmHg. Elementary analysis for C21H23FO4 (MW: 358): Calcd.(%): C 70.45 H 6.49 Found (%): C 69.73 H 6.88 Nuclear magnetic resonance spectrum (in CC14, TMS), #(ppm): 1.10 (s, 9H, -C(CH3)3), 1.50 (d, 3H, CH3-CH# ), 3.72 (q, 1H, CH3-CH ), 5.69 (s, 2H, -O-CH2-O-) and 7.00 to 7.60 (m, 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: EMI23.1 Infrared absorption spectrum ( ')cm71): 3100 to 2850 (aromatic, alkyl VC-H), 1755 (v COOR) and 1625-1420 (aromaticuC=C) Refractive index: nD26 = 1.5398 Ultraviolet absorption: #max = 248 nm. Example 8 [Acetoxymethyl 2-(2-fluoro-4-biphenylyl)propionate compound No. 1)] In 150 ml. of anhydrous DMF was dissolved 2.8 g. of potassium salt of FP. To the resulting solution was added 1.2 g. of acetoxymethyl chloride, and the reaction mixture was stirred at a room temperature for one hour. The resulting reaction mixture was treated and purified in the same manner as in Example 1 to give 2.56 g. (yield: 81 %) of the desired compound. The physicochemical properties of the obtained compound were consistent with those obtained in Example 1. Example 9 [l-(Acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 8)] In 20 ml. of anhydrous DMF was dissolved 2.44 g. (10 mmoles) of FP. To the resulting solution was added 1.38 g. (10 m moles) of anhydrous potassium carbonate, and then the reaction mixture was stirred at a room temperature for 30 minutes. After adding dropwise 1.45 g. (12 mmoles) of (l-chloroethyl) acetate purified by distillation at 0 to 5 C., the reaction was carried out at 600 to 70 C. for one hour with stirring. After completion of the reaction, the reaction mixture was cooled with ice, and then the inorganic material was filtered off. After distilling away the solvent under reduced pressure, 50 ml. of diethyl ether was added to the obtained residue. The resulting mixture was treated in the same manner as in Example 2 to give 2.97 g. (crude yield: 90 %) of light yellowish oily material. The resulting product was further distilled under reduced pressure in an atmosphere of nitrogen gas to give 2.4 g. (yield: 74 %) of the desired compound being a clear oily material having a boiling point of 1730 to l740C./0.8 mmHg. Elementary analysis for ClgH19F04 (MW: 330): Calcd. (%) C 69.09 H 5.76 Found (%) C 69.16 H 5.89 Nuclear magnetic resonance spectrum (in CC14, EMI24.1 Mass spectrum (20 eV, Direct) m/e: EMI24.2 EMI25.1 3060 to 2875 (aromatic, alkyl, uC-H), 1770 (vC = 0 ester) and 1630 aromatic vC = C) Refractive index: n24-5 = 1.5353 Ultraviolet absorption: Amax = 247 nm. Example 10 [l-(Propionyloxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 9)] The procedure of Example 9 was repeated except that 1.30 g. (10 mmoles) of (l-chloroethyl)propionate instead of (l-chloroethyl)acetate was employed to give 2.5 g. (yield: 73 %) of the desired compound being a clear oily material. Elementary analysis for C20H21FO4 (MW: 344): Calcd. (%): C 69.77 H 6.10 Found (%): C 69.97 H 6.12 Nuclear magnetic resonance spectrum (in CC14, TMS), #(ppm): 1.02 and 1.10 (2t, 3H, -COCH2CH3), 1.34 (d, 3H, EMI25.2 EMI26.1 57 [COC2H5]+ and 29 [C2H5]+ Infrared absorption spectrum Cii cm. ): 3060 to 2875 cml (aromatic, alkylVC-H), 1760 (vC=O) ester) and 1630 (aromatic vC=C) Refractive index nD24 = 1.5331 Ultraviolet absorption Amax = 247 nm. Boiling point: 1880 to 1910C./0.4 mmHg Example 11 [l-(Isobutyryloxyethyl) 2-(2-fluoro-4-biphenylyl) propionate (Compound No. 10)] The procedure of Example 9 was repeated except that 1.50 g. (10 mmoles) of l-chloroethyl isobutylate instead of l-chloroethyl acetate was employed to give 2.72 g. (yield: 76 %) of the desired compound being a clear oily material. Elementary analysis for C21H23FO4 (MW: 358): Calcd.(%): C 70.39 H 6.42 Found (%): C 70.57 H 6.44 Nuclear magnetic resonance spectrum (in CC14, TMS), # (ppm): 1.14 (2d, 6H -CH(CH3)2, 1.39 to 1.54 (n, 6H, EMI26.2 199 [base peak, EMI27.1 EMI27.2 Infrared absorption spectrum (v cm. 3060 to 2875 (aromatic, alkyl v C-H), 1760 (vC=O) ester) and 1630 (aromatic v C=C) Refractive index: n 24.5 = 1.5267 D Ultraviolet absorption:max = 247 nm. Boiling point: 1600 to 1640C./0.5 mmHg Example 12 [1-(Pivaloyloxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 11)] The procedure of Example 9 was repeated except that 2.1 g. (13 mmoles) of (l-chloroethyl) 2,2-dimethyl propionate instead of (l-chloroethyl)acetate was emplpyed to give 2.1 g. (yield: 56 %) of the desired compound being a clear oily material. Elementary analysis for C22H25FO4 (MW: 372): Calcd.(%): C 70.97 H 6.72 Found (%): C 71.18 H 6.68 Nuclear magnetic resonance spectrum (in CC14, TMS), # (ppm): 1.14 (2s, 9H, -C(CH3 ) 3' 1.39 to 1.54 (2d, 6H, EMI27.3 3.64 and 3.67 (2q, EMI27.4 6.61 to 6.81 (m, 1H, EMI27.5 6.95 to 7.43 (m, 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: EMI27.6 199 [base peak, EMI28.1 EMI28.2 Infrared absorption spectrum (v cm.-1): 3060 to 2875 (aromatic, alkyl v C-H), 1760 (vC=O ester), 1630 (aromatic v C=C) Refractive index: nD24.5 = 1.5203 Ultraviolet absorption: # max = 247 nm. Boiling point: 1660 to l720C./0.55 mmHg Example 13 [l-(Palmitoyloxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate (Compound No. 12)] The procedure of Example 9 was repeated except that 3.18 g. (10 mmoles) of (l-chloroethyl)palmitate instead of Cl-chloroethyl)acetate was employed to give 3.1 g. of clear oily material. The obtained product was purified by chromatography of silica gel [Kiesel gel 60 made by Merck & Co., Inc. (60 g.); Eluent: (1) cyclohexane, (2) cyclohexane : dichloromethane = 8 : 2, (3) cyclohexane : dichloromethane = 6 : 41 to give 2.67 g. (yield: 50.7 %) of the desired compound being a clear oily material. Elementary analysis for C33H47FO4 (MW: 326): Calcd.(%): C 75.29 H 8.94 Found (%): C 75.51 H 8.97 Nuclear magnetic resonance spectrum (in CC14, TMS), # (ppm): 0.83 to 1.72 (m, 35H, alkyl H), 2.18 (t, 2H, EMI28.3 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: 526 (Mt), 239 [base peak, (CO(CH2)14CH3)+] and EMI29.1 Infrared absorption spectrum (t cml): 3075 to 2875 (aromatic, alkyl v C-H), 1770 (vC=O ester), 1630 (aromatic v C=C) Refractive index : n 24.5 = 1.5028 D Ultraviolet absorption:-lmax = 247 nm. Example 14 [l-(Crotonoyloxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate (Compound No. 14)] The procedure of Example 9 was repeated except that 1.38 g. (10 mmoles) of (l-chloroethyl)crotonate purified by distillation instead of (l-chloroethyl) acetate was employed to give 1.6 g. yield: 44.9 %) of the desired compound being a clear oily material. Elementary analysis for C21H21FO4 (MW: 356): Calcd.(*): C 70.79 H 5.90 Found (%): C tl.00 H 5.93 Nuclear magnetic resonancespectrum (in CCl4, TMS), # (ppm): EMI29.2 -CH=CH-CH3), 7.02 to 7.40 (m, 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: EMI30.1 Infrared absorption spectrum (v cm.-): 3100 to 2900 (aromatic, alkyl v C-H), 1750 (uC=O ester) and 1665 (vC=C di-substituted olefine) Refractive index: nD24.5 = 1.5397 Ultraviolet absorption: A max = 247 mn. and 206 mn. Boiling point: 1950 to l970C./0.3 mmHg Example 15 [[1-(3,3-dimethylacryloyloxy)ethyl] 2-(2-fluoro-4 biphenylyl)propionate compound No. 15)] The procedure of Example 9 was repeated except that 2.43 g. (15 mmoles) of Cl-chloroethyl)-3,3- dimethylacrylate purified by distillation instead of (l-chloroethyl)acetate was employed to give 3.19 g. yield: 85.1 %) of the desired compound being a clear oily material. Elementary analysis for C22H23FO4 (MW: 370): Calcd.(%): C 71.35 H 6.22 Found (%): C 71.14 H 6.21 Nuclear magnetic resonance spectrum (in CC14, EMI30.2 5.46 to 5.60 (m, 1H, olefinic H), 6.69 to 6.89 EMI31.1 Infrared absorption spectrum (v cm.-1): 3075 to 2900 (aromatic, alkyl v C-H), 1750 (vC=O ester), 1660 (vC=C, tri-substituted olefine) Refractive index: n24-5 = 1.5423 D Ultraviolet absorption: 1 max = 244 nm. and 206 nm. Boiling point: l940C./0.6 mmHg Example 16 [1-(2,4-Hexadienoyloxy)ethyl] 2-(2-fluoro-4-biphenylyl) propionate compound No. 16)] The procedure of Example 13 was repeated except that 2.26 g. (13 mmoles) of (1-chloroethyl)-2,4- hexadienoate purified by distillation instead of (l-chloroethyl)palmitate was employed to give 3.17 g. (yield: 83.0 %) of the desired compound being a clear oily material. Elementary analysis for C23H23FO4 (MW:'382): Calcd.(%): C 72.25 H 6.02 Found (%): C 72.47 H 6.04 Nuclear magnetic resonance spectrum (in CC14, TMS), #(ppm): EMI31.2 EMI32.1 Infrared absorption spectrum ( v cm.-1): 3075 to 2875 (aromatic, alkyl v C-H), 1755 (vC=O ester), 1652 (olefinic v C=C) Refractive index: nD24.5 = 1.5612 Ultraviolet absorption: A max = 254 nm. Example 17 [l-(Acetoxy)propyl 2-(2-fluoro-4-biphenylyl)propionate compound No. 13)] The procedure of Example 13 was repeated except that 1.4 g. (10 mmoles) of (l-chloropropyl)acetate purified by distillation instead of (l-chloroethyl) palmitate was employed to give 1.2 g. (yield: 34.8 %) of the desired comound being a blown oily material. Elementary analysis for C20H21FO4 (MW: 344): Calcd.(%): C 69.77 H 6.10 Found (*): C 69.99 H 6.12 Nuclear magnetic resonance spectrum (in CC14, TMS), # (ppm): EMI32.2 EMI33.1 Infrared absorption spectrum (v cm. ): 3080 to 2900 (aromatic, alkylv C-H), 1770 (aC=O ester), 1632 (aromatic tC=C) Refractive index: nD24.5 = 1.5310 Ultraviolet absorption: A max = 247 nm. Example 18 [1- (Acetoxy )ethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 8)] Into 140 ml. of anhydrous DMF was suspended 2.82 g. (10 mmoles) of potassium salt of FP. To the resulting suspension was added dropwise 1.47 g. (12 mmoles) of (l-chloroethyl)acetate dissolved in 10 ml. of anhydrous DMF while keeping the reaction mixture at a temperature of 60 C., and then the resulting reaction mixture was stirred at 80 C. for one hour. After completion of the reaction, the resulting reaction mixture was treated and purified in the same manner as in Example 9 to give 2.5 g. (yield: 75 %) of the desired compound being a clear oily material. The physicochemical properties of the compound were consistent with those obtained in Example 9. Example 19 [1-(Propionyloxy)ethyl 2-(2-fluoro-4- biphenylyl) propionate (@@@@pound No. 9)] To 30 ml. of dehydrated acetonitrile were added 0.84 g. (3 mmoles) of potassium salt of FP, 0.3 g. (3 mmoles) of triethylamine and 0.5 g. (3 mmoles) of potassium iodide. To the resulting reaction mixture was added 0.47 g. (4 mmoles) of (l-chloroethyl)propionate at a room temperature with stirring, and then the reaction was carried out at 600C. for 5 hours. After cooling, the resulting residue was filtered off, and then 100 ml. of ether was added to the filtrate. The resulting organic layer was washed successively with 10 % sodium carbonate solution, water and a saturated sodium chloride aqueous solution by a conventional method, and then dried with magnesium sulfate. After distilling away the solvent, the obtained oily material was distilled under reduced pressure to give 0.84 g. (yield: 83 %) of the desired compound. The physicochemical properties of the compound were consistent with those obtained in Example 10. Example 20 [l-(Pivaloyloxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate compound No. 11)] To 40 ml. of dehydrated acetonitrile was added 20 mg. of 18-crown-6, and then the resulting reaction mixture was stirred at a room temperature for 30 minutes. To the resulting reaction mixture were added 0.56 g. (2 mmoles) of potassium salt of FP and then 0.49 g. (3 mmoles) of (l-chloroethyl)-2, 2-dimethylpropionate , and the reaction was carried out at 50 C. for 8 hours. After cooling and adding 100 ml. of ether, the resulting reaction mixture was treated and purified in the same manner as in Example 12 to give 0.37 g. (yield: 50 %) of the desired compound. The physicochemical properties of the compound were consistent with those obtained in Example 12. Example 21 [l-(Acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No. 8)] In 25 ml. of acetonitrile was dissolved 2.44 g. (10 mmoles) of FP. To the resulting solution was added 1.38 g. (10 mmoles) of anhydrous potassium carbonate, and then the reaction mixture was stirred at a room temperature for 30 minutes. After adding dropwise 2.4 g. (20 mmoles) of (l-chloroethyl)acetate purified by distillation, the reaction was carried out at a room temperature for 4 hours, and then at 400C. for one hour with stirring. After cooling, the resulting residue was filtered off, and 100 ml. of ether was added to the filtrate. The resulting organic layer was washed successively with 10 % sodium carbonate solution, water and a saturated sodium chloride aqueous solution, and then dried with magnesium sulfate. After distilling away the solvent, the obtained oily material was distilled under reduced pressure to give 2.3 g. (yield: 71 %) of the desired compound. The physicochemical properties of the compound were consistent with those obtained in Example 9. Example 22 [l-(Acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate compound No. 8)] The procedure of Example 9 was repeated except that 1.67 g. (10 mmoles) of (l-brombethyl)acetate instead of (l-chloroethyl)acetate was employed to give 2.56 g. (yield: 81 %) of the desired compound being a clear oily material. The physicochemical properties of the compound were consistent with those obtained in Example 9. Example 23 [2-(Acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate compound No. 17] In 25 ml. of anhydrous dichloromethane was dissolved 2.44 g. (10 mmoles) of FP. To the resulting solution were added 1.04 g. (10 mmoles) of (2-acetoxy)ethyl alcohol and 0.13 g. (1 mmole) of p-dimethylamiopyridine with stirring at OOC. After adding dropwise 2.3 g. (11 mmoles) of dicyclohexyl carbodiimide dissolved in anhydrous dichloromethane, the reaction was carried out at a room temperature for one hour. After ice-cooling, the insoluble material was filtered off, and then the organic layer was washed successively with 0.1 N hydrochloride, a saturated sodium hydrogencarbonate solution and a saturated sodium chloride solution, and dried with anhydrous magnesium sulfate. After distilling away the solvent under reduced pressure, the resulting clear oily material was distilled under reduced pressure for purification. The fractions of distillate having a boiling point of 2340 to 238 C./mmHg were collected to give 2.6 g. (yield: 80 %) of the desired compound being a clear oily material. Elementary analysis for ClgHlgFO4 (MW: 330.4): Calcd.(%): C 69.07 H 5.75 Found (%): C 69.28 H 5.77 Nuclear magnetic resonance spectrum (in CCl4, TMS),8 (ppm): EMI36.1 Infrared absorption spectrum C v cm.l): 3100 to 2850 (aromatic, alkyl v C-H), : 1760 (esterv C=O), 1625 to 1420 (aromatic v C=C=) Refractive index: n27 = 1.5427 Example 24 [2-(Propionyloxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate (Compound No. 18)] In 25 ml. of anhydrous DMF was dissolved 2.44 g. (10 mmoles) of FP. To the resulting solution was added 1.38 g. (10 mmoles) of anhydrous potassium carbonate, and the reaction mixture was stirred at a room temperature for one hour. After adding dropwise 1.77 g. (13 mmoles) of C2-propionyloxy)ethyl chloride, the reaction was carried out at 400 to 500C. for one hour with stirring. After ice-cooling, the inorganic material was filtered off, and then the solvent was distilled away under reduced pressure. After adding 50 ml. of diethyl ether to the resulting residue, the mixture was washed successively with water, 10 % sodium carbonate solution and a saturated sodium chloride solution, and then the organic layer was dried with anhydrous magnesium sulfate. After distilling away the solvent under reduced pressure, the resulting clear oily material was distilled under reduced pressure for purification. The fractions of distillate having a boiling point of 2250 to 2280C./0.5 mmHg were collected to give 2.55 g. (yield: 74 %) of the desired compound being a clear oily material. Elementary analysis for C20H21FO4 (MW: 344.4): Calcd.(%): C 69.69 H 6.10 Found (%): C 69.90 H 6.12 Nuclear magnetic spectrum (in CC14, TMS), (ppm): EMI37.1 Infrared absorption spectum ( > cm."): 3100 to 2850 (aromatic alkyl C-H), 1760 (esterv C=O), 1625 to 1420 (aromatic y C=C) Refractive index: n27 = 1.5397 D Example 25 [2-(Crotonoyloxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate (Compound No. 19)] The procedure of Example 24 was repeated except that 2.89 g. (15 mmoles) of C2-crotonoyloxy)ethyl bromide instead of (2-propionyloxy)ethyl chloride was employed to give 3.39 g. (yield: 63.4 %) of the desired compound being a clear oily material having a boiling point of 205 to 215 C./1.5 mmHg. Elementary analysis for C21H21FO4 (MW: 356.4): Calcd.(%): C 70.77 H 5.89 Found (%): C 70.98 H 5.91 Nuclear magnetic resonance (in CCl4, TMS), # (ppm): EMI38.1 proton), 6.44 to 7.33 (m, 9H, aromatic,olefinic proton) Mass spectrum (20 eV, Direct) m/e: 356 (M.+), 226, 199 [base peak, EMI38.2 Infrared absorption spectrum Cl, cm71): 3100 to 2850 (aromatic alkylYCH), 1720 to 1750 (esterv C=O), 1665 (olefinicu C=C) Refractive index: nD27 = 1.5461 D Example 26 [2-(3,3-Dimethylacryloyloxy)ethyl 2-(2-fluoro-4biphenylyl)propionate (compound 20)] The procedure of Example 24 was repeated except that 3.10 g. (15 mmoles) of 2-(3,3-dimethylacryloyloxy) ethylbromide instead of C2-propionyloxy)ethyl chloride, was employed to give 3.31 g. (yield: 59.6 %) of the desired compound being a clear oily material having a boiling point of 2250 to 2280C./0.8 mmHg. Elementary analysis for C22H23FO4 (MW: 370.5): Calcd.(%): C 71.32 H 6.21 Found (%): C 71.53 H 6.24 Nuclear magnetic resonance spectrum (in CCl4, TMS),a (ppm): EMI39.1 1.72 (s, 3H, olefinic -CH3), 2.03 (s, 3H, olefinic -CH3), 3.62 (q, EMI39.2 5.40 (m, 1H, olefinic proton) and 6.82 to 7.52 (m, 8H, aromatic proton) Mass spectrum (20 eV, Direct) m/e: 370 (M.+), 226, 199 [base peak, EMI39.3 Infrared absorption spectrum ( L' cm.-1): 3100 to 2850 (aromatic alkyluC-H), 1745, 1725 ester C=O) and 1655 Refractive index: nD27 = 1.5431 Example 27 [2-( 3,7-Dimethyl-2,6-octadienoyloxy)ethyl 2-(2-fluoro-4 biphenylyl)propionate (Compound No.22)] The procedure of Example 24 was repeated except that 1.68 g. (10 mmoles) of 3,7-dimethyl-2,6-octadienoic acid, 10 ml. of anyhdrous DMF, 1.38 g. (10 mmoles) of anhydrous potassium carbonate and 3.51 g. (10 mmoles) of 2-bromoethyl 2-(2-fluoro-4biphenylyl)propionate were employed. The resulting residue was purified by chromatography of silica gel (Kiesel gel 60 F (90 g.); Developing solvent: a mixed solvent of dichloromethane and cyclohexane) to give 3.1 g. (yield: 83.7 %) of the desired compound being a clear oily material having a boiling point of not less than 250 C./mmHg. Elementary analysis for C27H31FO4 (MW: 438.6): Calcd.(%): C 73.94 H 7.07 Found (%): C 74.16 H 7.06 Nuclear magnetic resonance spectrum (in CCl4, TMS), # (ppm): EMI40.1 1.46, 1.55 (ss, 6H, olefinic -CH3 x 2), 1.96 (m, 7H, olefinic -CH3, blefinic -CH2-CH2-), 3.96 (s, 4H, EMI40.2 4.66 to 4.92 (m, 1H, olefinic proton), 5.24 (s, 1H, olefinic proton) and 6.64 to 7.18 (m, 3H, aromatic proton) Mass spectrum (20 eV, Direct) m/e: 438 (Mf), 226, 199 [base peak EMI40.3 Infrared absorption spectrum ( v cm.-1): 3100 to 2850 (aromatic alkyl C-H), 1745, 1730 (esteriiC=O) and 1650 (olefinic v C=C) Refractive index: : nD = 1.5435 D Example 28 [2-(2,4-Hexadienoyloxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate (Compound No. 21)] To 200 ml. of anhydrous acetonitrile were added 0.1 g. of 18-crown-6, 1.5 g. (20 mmoles) of potassium sorbate and 3.5 g. (10 mmoles) of (2-bromoethyl) 2-(2 fluoro-4-biphenylyl)propionate, and then the resulting reaction mixture was stirred at 50 0C. for 8 hours. The resulting reaction mixture was treated and purified by conventional methods in the same manner as in Example 27 to give 3.5 g. (yield: 91.6 %) of the desired compound being a white crystal having a melting point of 59 to 61 C. Elementary analysis for C23H23FO4 (MV: 382.3): Calcd.(%): C 72.26 H 6.02 Found (%): C 72.40 H 6.04 Nuclear magnetic resonance spectrum (in CCl4, TMS), # (ppm): EMI41.1 proton), 5.63 to 5.72 (m, 211, olefinic proton) and 6.60 to 7.18 (m, 9H, aromatic, olefinic proton) Mass spectrum (20 eV, Direct) m/e: EMI41.2 Infrared absorption spectrum ( > cm.-1): 3100 to 2850 (aromatic, alkyl PC-H), 1745, 1710 (esterv C=O) and 1655 (olefinic v C=C) Example 29 [2-(Acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate (Compound No.17)] In 35 ml. of anhydrous pyridine was dissolved 7.55 g. (26.2 mmoles) of 2-hydroxyethyl-2-(2-fluoro-4 biphenylyl)propionate. To the resulting solution was added dropwise 4 g. (39.3 mmoles) of acetic anhydride with ice-cooling. After completion of the addition, the resulting reaction mixture was stirred at 400C. for 3 hours, and then cooled. The reaction mixture was poured into water added with ice and extracted with 400 ml. of diethyl ether. The resulting extract was washed successively with 10 % hydrochloride and water, and the organic layer was dried with anhydrous magnesium sulfate. After distilling away the solvent under reduced pressure, the obtained clear oily material was distilled under reduced pressure for purification to give 7.61 g. (yield: 88 %) of the desired compound being a clear oily material. The physicochemical properties of the obtained compound were consistent with those obtained in Example 23. Example 30 [2-(Acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate compound No. 17)] To 100 ml. of anhydrous acetonitrile were added 2.82 g. (10 mmoles) of potassium salt of FP, 0.1 g. of 18-crown-6 and 1.22 g. (10 mmoles) of 2-acetoxyethyl chloride, and the reaction mixture was stirred at a room temperature for 8 hours. The resulting reaction mixture was treated by a conventional method and purified in the same manner as in example 23 to give 1.48 g. (yield: 44.8 %) of the desired compound being a clear oily material. The physicochemical properties of the obtained compound were consistent with those obtained in Example 23. Example 31 [2-(Propionyloxy)ethyl 2-(2-fluoro-4-biphenylyl) propionate compound No. 18)] To 100 ml. of anhydrous acetonitrile were added 2.82 g. (10 mmoles) of potassium salt of FP, 1.4 g. (10 mmoles) of 2-propionyloxyethyl chloride, 1 g. of triethylamine and 1.6 g. of potassium iodide, and then the reaction mixture was stirred at 60 C. for 5 hours. The resulting reaction mixture was post-treated by a conventional method, and distilled under reduced pressure for purification to give 2.86 g. (yield: 83 %) of the desired compound being a clear oily material. The physicochemical properties of the obtained compound were consistent with those obtained in Example 24. Example 32 [3,3-Dimethyl-2-[2-(2-fluoro-4-biphenylyl)propionyloxy]- -butyrolactone (Compound No. 23)J In 40 my. of anhydrous dichloromethane were dissolved 2.44 g. (10 mmoles) of FP, 1.3 g. (10 mmoles) of 2-hydroxy-3,3-dimethylbutyrolactone and 0.1 g. of p-dimethylaminopyridine. To the resulting solution was added dropwise 2.0 g. (10 mmoles) of dicyclohexylcarbodiimide, and the resulting reaction mixture was stirred at a room temperature for one hour. After completion of the reaction, the reaction mixture was cooled to a temperature of 0 C., and the precipitated dicyclohexylurea was filtered off. The resulting filtrate was washed successively with 0.1 N hydrochloride, a saturated sodium bicarbonate solution and a saturated sodium chloride solution, and then the organic layer was dried with anhydrous magnesium sulfate. After distilling away the solvent under reduced pressure, the resulting light yellowish liquor was distilled under reduced pressure for purification to give 2.41 g. (yield: 68 %) of the desired compound being an oily material having a boiling point of 1980 to 2090C./0.9 mmHg. Elementary analysis C21H21FO4 (MW: 356): Calcd.(%): C 70.79 H 5.90 Found (%): C 70.93 H 5.92 Nuclear magnetic resonance spectrum (in CCl4, TMS), 8(pom): 0.86 to 1.17 (s x 4, 6H, lactone CH3 x 2), EMI44.1 8H, aromatic H) Mass spectrum (20 eV, Direct) m/e: EMI44.2 Infrared absorption spectrum (v cm.-1): 3100 to 2900 (aromatic, alkyl C-H), 1760 (vC=O ester) and 1800 (I-lactoneuC=O) Refractive index: n 24.5 = 1.5485 D Ultraviolet absorption: # max = 247 nm Example 33 t3,3-Dimethyl-2-[2-(2-fluoro-4-biphenylyl)propionyloxy]- 7-butyrolactone (Compound No. 23)] In 50 ml. of anhydrous tetrahydrofuran were dissolved 2.44 g. (10 mmoles) of FP, 1.3 g. (10 mmoles) of D,L-pantoyllactone and 2.6 g. of triphenylphosphin. After adding dropwise 1.7 g. (10 mmoles) of azocarboxylic acid diethyl ester with stirring at 0 C., the reaction was carried out at 0 C. for one hour, and then at a room temperature for one hour. After adding 20 ml. of ether to the reaction mixture, the resulting precipitate was filtered off. The resulting organic layer was washed three times with water, and then dried with anhydrous magnesium sulfate. After distilling away the solvent, the obtained residue was distilled under reduced pressure for purification to give 2.3 g. (yield: 65 %) of the desired compound being a clear oily material. The physicochemical properties of the obtained compound were consistent with those obtained in Example 32. Example 34 [3,3-Dimethyl-2-[2-(2-fluoro-4-biphenyl-yl)propionylOxy]- f-butyrolactone (compound 23)] In 10 ml. of anhydrous DMF was dissolved 2.44 g. (10 mmoles) of FP in an atmosphere replaced with argon gas. After adding dropwise N,N'-carbonyldiimidazole dissolved in anhydrous DMF at a room temperature, the reaction was carried out for one hour with stirring. To the resulting reaction mixture was added dropwise 1.3 g. (10 mmoles) of D,L-pantolactone with ice-cooling. After completion of the addition, the reaction was carried out at a room temperature for 3 hours with stirring. The resulting reaction mixture was concentrated under reduced pressure, and then the residue was dissolved in ether. The resulting mixture was washed successively with water, 10 % citric acid, water, a saturated sodium bicarbonate solution and a saturated sodium chloride solution, and then the organic layer was dried with anhydrous magnesium sulfate. After distilling away the solvent under reduced pressure, the obtained residue was distilled under reduced pressure for purification to give 2.5 g. (yield: 71 %) of the desired compound being a clear oily material. The physicochemical properties of the obtained compound were consistent with those obtained in Example 32. Example 35 [Tablet] To 100 mg. of l-(acetoxy)ethyl 2-(2-fluoro-4biphenylyl)propionate was added 30 mg. of Aerosil (registered trademark, made by Japan Aerosil Co., Ltd.), and the mixture was pulverized. To the resulting powder were added 35 mg. of dibasic calcium phosphate anhydrous, 45 mg. of Avicel (registered trademark, made by Asahi Kasei Co., Ltd.), 6 mg. of ECG 505 (carboxymethyl cellulose calcium salt made by Nichirin Chemical Industry Co., Ltd.) and 4 mg. of calcium stearate, and then the mixture was blended and compressed to give a tablet. Example 36 [Suppository] A mixture of 1240 mg. of Witepsol H-15 (mixture of triglyceride and monoglyceride made by Dinamit Novel Co., Ltd., Witepsol: registered trademark) and 310 mg. of Witepsol E-85 (made by Dinamit Novel Co., Ltd.) was melted at 60 c to 70 C. After cooling the mixture to a temperature of 45 C., 150 mg. of 1-(acetoxy)ethyl 2-(2-fluoro-4biphenylyl) propionate was added thereto. The resulting mixture was stirred until it became homogeneous, and then 1.7 g. thereof was injected in a container of 1.9 ml. at 400C. to make solid with cooling. Example 37 [Soft gelatin capsule] (a) For oral administration In 100 mg. of PEG 400 (polyethyleneglycol) was dissolved 100 mg. of l-(acetoxy)ethyl 2-(2-fluoro-4biphenylyl)propionate, and then 200 mg. of the resulting solution was filled up in a soft gelatin capsule (made by R.P. Scherer Co., Ltd.; size: 3 to 2 round A). (b) For Suppositories In 260 mg. of PEG 400 was dissolved 150 mg. of l-(acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate, and then 410 mg. of the resulting solution was filled up in a soft gelatin capsule (made by R.P. Scherer Co., Ltd.; size: 85 to 86 suppository A). Example 38 [Cream] According to the following formulation, a 1 % gel cream was prepared as follows: l-(Acetoxy)ethyl 2-(2-fluoro-4-biphenylyl) 10 g. propionate Myristin isopropyl (made by Nikko 100 g. Chemicals Co., Ltd.) Ethanol 50 g. Polyoxyethylene monostearate 10 g. Carboxyvinyl polymer-940 15 g. Coconut oil (fatty acid diethanol amide) 30 g. Distilled water Sufficient amount Total 1000 g. In myristin isopropyl was dissolved l-(acetoxy)ethyl 2-(2-fluoro-4-biphenylyl)propionate. To the resulting solution were added ethanol, carboxyvinyl polymer-940 swelled in 500 ml. of water and polyoxyethylene dissolved in 100 ml. of water, and then the resulting mixture was throughly stirred until it became homogeneous. To the homogeneous mixture were added coconut oil blended in 100 ml. of water and sufficient amount of distilled water, and then the resulting mixture was throughly stirred until it became homogeneous. Example 39 [Inhibitory effect on carrageenan-induced edema] With respect to the present FP derivatives (Compound Nos. 1 to 23), there was tested inhibitory effect on carrageenan-induced edema. Five Wistar male rats weighing about 150 g. were used as one group. A 1 % dispersion of carrageenan was injected intracutaneously into the foot pad of the right hind foot in a dose of 0.1 ml./rat. The compounds to be tested were orally administered to the rats fasted for 15 hours one hour before the carrageenan injection, or intravenously administered 2 hours after the carrageenan injection. The volume of the foot subjected to the injection was measured by a mercury plethysmography 3 hours after the carrageenan injection on the test by oral route or 2 hours after the carrageenan injection on the test by intravenous route, and the carrageenan-induced edema was estimated from the obtained measurments. The results are shown in Table 2. Table 2 ED50 Compound mg./kg. No. p.o. i.v. 1 0.5 0.08 2 0.5 0.07 3 0.6 0.10 4 0.6 0.08 5 0.5 0.06 6 1.5 0.50 7 0.6 0.10 8 0.5 0.05 9 0.7 0.06 10 1.5 0.1 Compounds 11 2.5 0.6 of the 12 > s.o > 5.0 invention 13 1.5 0.1 14 0.9 0.08 15 2.5 .0.3 16 20 0.3 17 0.7 18 0.7 19 0.9 20 1.0 21 0.9 - 22 0.9 23 0.5 0.05 acemethacin 8.3 Comparative indomethacin 5.5 1.25 compounds FP 0.8 0.3 Example 40 [Gastric ulceration] With respect to the present FP derivatives (Compound Nos. 1 to 23), there was tested gastric ulceration. Five Wistar male rats weighing about 150 g. were used as one group. The rats were fasted for 24 hours before the test. Six hours after orally administration of the present compounds to be tested, there was observed an existence of gastric ulcer by the method of Okabe et al (Ohyoyakuri, 16, 241 to 247 (1978). The UD50 values were calculated from the ulcer incidence of gastric ulcer by the method of Litchfield-Wilcoxon. The results are shown in Table 3. Table 3 Compound UD50 No. mg./kg. 1 3.6 2 2.5 3 2.0 4 2.0 5 2.0 6 5.0 7 2.5 8 2.5 9 3.0 10 5.0 Compounds 11 10.0 of the 12 > lo.o invention 13 5.0 14 4.0 15 7.0 16 7.0 17 2.0 18 2.0 19 3.0 20 3.0 21 3.0 22 3.0 23 2.5 acemethacin 17.5 Comparative indomethacin 5.0 compounds FP 1.0 Example 41 [Hydrolysis of FP derivatives in plasma] With respect to the present FP derivatives (Compound Nos. 1 to 23), there was tested the hydrolysis rate in human plasma or rat plasma. The compounds to be tested (Compound Nos. 1 to 16) and the compounds to be tested (Compound Nos. 17 to 23) were, respectively, added to 1 ml. of human plasma and 1 ml. of rat plasma, in an amount corresponding to 50 pg. of FP. Each reaction mixture was incubated at 370C. for one hour. The free FP formed by esterase in the plasma was extracted with benzene. After treating the extract with N,O-bis(trimethylsilylacetamide) for trimethylsilylation, the obtained material was determined by gas-liquid chromatography. The results are shown in Table 4. Table 4 Compound Hydrolyzing No. rate (%) 1 97.5 2 94.6 3 86.3 4 81.4 5 114.8 6 3.8 7 70.3 8 70.7 9 56.3 10 35.2 Compounds 11 8.3 of the 12 2.0 invention 13 36.0 14 42.0 15 19.8 16 20.4 17* 100.9 18* 98.9 19* 99.5 20* 99.8 21* 100.3 22* 101.0 23* 72.3 acemethacin 4.2 Comparative ind@metha@in compounds FP ¯* Values in rat plasma. Example 42 [Acute toxicity] Eight male SLC-ddY mice 5 week old weighing 25 to 30 g. were used as one group. The compound to be tested was orally administered using a stomach tube. The animals were kept under observation for 2 weeks. The numbers of dead animals were counted and the LD50 values were calculated by the method of Litchfield Wilcoxon. The results are shown in Table 5. Table 5 Compound LD50 No. mg./kg. 1 880 2 750 3 600 4 600 5 900 6 > 1000 7 840 8 650 9 800 10 880 Compounds 11 > 1000 of the 12 > 1000 invention 13 900 14 800 15 1000 16 1000 17 650 18 700 19 800 20 880 21 750 22 750 23 670 acemethacin 18.0 Comparative indomethacin 14.0 compounds FP 440

Claims: WHAT WE CLAIM IS: 1. A biphenylylpropionic acid derivative having the formula (I): EMI56.1 wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (II): EMI56.2 wherein R1 is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, and m is 0 or an integer of 1, provided that when R1 is a lower alkyl group, m is 0, or a lactone having the formula (III): EMI56.3 wherein R3 and R4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. 2. The biphenylylpropionic acid derivative of Claim 1, wherein R is acetoxymethyl, propionyloxymethyl, isobutyryloxymethyl, pivaloyloxymethyl, palmitoyloxymethyl, crotonoyloxymethyl, 3,3-dimethylacryloyloxymethyl, l-acetoxyethyl, l-acetoxypropyl, l-propionyloxyethyl, l-isobutyryloxyethyl, l-pivaloyloxyethyl, l-palmitoyloxyethyl, l-crotonoyloxyethyl, l-(3,3-dimethylacryloyloxy) ethyl, l-(2,4-hexadienoyloxy)ethyl, 2-acetoxyethyl, 2-propionyloxyethyl, 2-crotonoyloxyethyl, 2-(3,3-dimethylacryloyloxy)ethyl, 2-(2,4-hexadienoyloxy)ethyl, 2-(3,7 dimethyl-2,6-octadienoyloxy)ethyl or 3,3-dimethyl-7- butyrolactone-2-yl group. 3. A process for preparing a biphenylylpropionic acid derivative having the formula (I): EMI57.1 wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (II): EMI57.2 wherein R1 is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, m is 0 or an integer of 1, provided that when R1 is a lower alkyl group, m is 0, or a lactone having the formula (III): EMI57.3 wherein R3 and R4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms; n is an integer of 1 or 2, which comprises reacting 2-(2-fluoro-4-biphenylyl)propionic acid or the salt thereof having the formula (IV): EMI57.4 wherein Y is hydrogen atom or a metal salt, with a compound having the formula (V): EMI58.1 wherein R2 and m are as defined above and X is a halogen atom, or a compound having the formula (VI): EMI58.2 wherein R3, R4 and n are as defined above. 4. A process for preparing a biphenylylpropionic acid derivative having the formula EMI58.3 0. wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (IIo): EMI58.4 wherein R2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, which comprises reacting biphenylylpropionic acid 2-hydroxyethyl ester having the formula (VII): EMI58.5 with an acid anhydride having the formula (VIII): EMI58.6 5. wherein R is a lower alkyl group having 1 to 2 carbon atoms or an alkenyl group having 2 to 7 carbon atoms. 5. A process for preparing a biphenylylpropionic acid derivative having the formula EMI59.1 wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (II): EMI59.2 wherein R2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atomss, which comprises reacting a biphenylylpropionic acid 2-haloethyl ester having the formula (IX) EMI59.3 wherein X is a halogen atom, with an acid having the formula (X): R5COOH (X) wherein R5 is a lower alkyl group having 1 to 2 carbon atoms or an alkenyl group having 2 to 7 carbon atoms. 6. A pharmaceutical composition having antiinflammatory, analgesic and antipyretic activities which comprises, as the effective ingredient, an effective amount of a biphenylylpropionic acid derivative having the formula (I): EMI60.1 wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula (II): EMI60.2 R 1. wherein R1 is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R2 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, m is 0 or an integer of 1, provided that when R1 is a lower alkyl group, m is 0, or a lactone having the formula (III): EMI60.3 wherein R3 and R4 are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2 and a pharmaceutically acceptable carrier. 7. The pharmaceutical composition of Claim 6 wherein R is acetoxymethyl, propionyloxymethyl, isobutyryloxymethyl, pivaloyloxymethyl, palmitoyloxymethyl, crotonoyloxymethyl, 3,3-dimethylacryloyloxymethyl, l-acetoxyethyl, l-acetoxypropyl, l-propionyloxyethyl, l-isobutyryloxyethyl, l-pivaloyloxyethyl, l-palmitoyloxyethyl, l-crotonoyloxyethyl, l-(3,3-dimethylacryloyloxy) ethyl, l-(2,4-hexadienoyloxy)ethyl, 2-acetoxyethyl, 2-propionyloxyethyl, 2-crotonoyloxyethyl, 2-(3,3-dimethylacryloyloxy)ethyl, 2-(2,4-hexadienoyloxy)ethyl, 2-(3,7-dimethyl-2,6-octadienoyloxy)ethyl or 3,3-dimethyl 7-butyrolactone-2-yl group. 8. The pharmaceutical composition of Claim 6, which is in a preparation form of tablet, capsule, suppository and cream.

Inventors: ICHIKAWA, KIYONOSHIN, MASUMOTO, SHOZO, MATSUMURA, MISAKO, MIMURA, MITSUO, OKUMURA, MAKOTO, TOHNO, MASAO, UCHIDA, KATSUHIRO 336, KASHIWAYA-CHO
Applicants: KAKEN PHARMACEUTICAL CO., LTD.
Application year: 1983
Main classification: C07C69
IPC codes: C07D307