PROCESSES FOR PREPARING TABLETS BY A MODIFIED 'WET-GRANULATION' TECHNIQUE

Abstract: The invention relates to a process for preparing a wet granulate suitable for use in manufacturing tablets by com­ pression and compaction thereof. The process comprises first forming an intimate mixture of particulate-solid materials including pharmacologically or like active matter and tabletting aids. Then one predeter­ mines a quantity of granulating fluid needed to convert the entire particulate-solid mixture into a desired moist, coher­ ent, non-pasty mass as known per se but homogenizes part only of the particulate-solid materials, separately from the remainder thereof, with a chosen amount of granulating fluid, that chosen amount being at least 90% by weight of the aforesaid predetermined quantity of granulating fluid, so as to form a substantially-homogeneous slurry wherein the percentage by weight of solids in the slurry, namely: Total Solids, i.e. both dissolved and undissolved × 100 Total Slurry, i.e. fluids plus total solids is at least about 25% w/w. Thereafter, the remaining part of the particulate-solid material is moistened in the manner of «wet-granulation» as known per se but with the thus-pre­ pared slurry (and then as necessary with the balance of the granulating fluid, if any) so as thus to form the desired sub­ stantially-uniform, moist, coherent, non-pasty mass ready for granulation.

Description: "PROCESSES FOR PREPARING TABLETS BY A MODIFIED 'WET-GRANULATION' TECHNIQUE" This invention relates to processes for preparing tablets by a modified "wet-granulation" technique - and especially, but not exclusively, tablets which have a high active-matter content. A variety of substances meant to be taken by humans and other animals (especially, but not exclusively, pharmaceutical substances intended for oral administration) are often formulated as tablets. The term "tablet" should be sufficiently familiar to require no explanation; but, in case of need, can be defined as follows: - as used herein the term "tablet" includes not only tablets proper but also similar discrete bodies, perhaps of other shapes and sometimes known by different names, above all so-called "caplets" (i.e. capsuleshaped tablets, which are easier than tablets to swallow) and also such things as lozenges, pills, troches and dragees - and the term is here used to refer to mixtures of particulate solid materials, which have been brought together in various ways and finally compressed so that they become compacted into shaped entities able to persist under normal handling conditions but to disintegrate at the desired site, usually within the body and above all in the digestive tract. Most tablets are intended to be swallowed, and thus must be kept within the maximum bulk-limit which (dependent slightly upon its shape) an average person is able and willing to swallow. The "size" of the tablets they produce is conventionally defined by tabletters in terms not of their bulk but of their weight. There is room for debate as to what precisely is the absolutely maximum "swallowable" size of tablet, which must depend on the shape of the tablet and on the individual who is to swallow it. We however take the view that the absolutely maximum "swallowable" size of tablet can be set at a weight of no more than say 1200 milligrams; and many might choose tQ set it much lower at a weight of not more than say about 850 milligrams. Whatever weight limit one adopts (be it 850 mg or 1200 mg, or preferably something in between - usually say no more than 1 g) it follows that any tablet which is to be swallowed must accommodate all of its ingredients, not only the activematter but also every other necessary or desirable type of ingredient, within that weight limit. Moreover, that consideration not only applies to tablets intended to be swallowed, but to some extent also affects tablets of other kinds, because so much of the available tabletting machinery is dimensioned to produce swallowable tablets that in practice it is often most convenient to make other kinds of tablets on the same machinery and thus to the same dimensions. For most purposes all necessary ingredients can be accommodated within an 850 mg tablet, and certainly within a 1200 mg tablet. There are, however, situations which the above-discussed overall weight limitations on tablet size create a hitherto-insurmountable obstacle. In a pharmaceutical context, one can readily appreciate that the dose necessary at any one administration should desirably be given in the fewest possible tablets, thus if possible in just a single tablet. In the relatively rare event that the dose of active-matter necessary at any one administration should exceed the maximum swallowable size of tablet, clearly it is then quite impossible for that dose to be contained in just one swallowable tablet. More usually, however, the amount of active-matter to be given at any one administration is less than the swallowable maximum, so that notionally it could all be contained within a single tablet - and yet in practice that till now has proved impossible with some compounds and combinations of compounds, because the amount of active-matter so closely approaches the swallowable maximum that the balance is not enough to accommodate the tabletting aids (and possibly other ingredients) which are pharmacologically-inert but whose presence is vital to the manufacture of a satisfactory tablet when, as so often, the compression characteristics of the activematter are poor. In the manufacture of tablets, the final compression of each tablet takes place between the punches within a die, after the latter has been filled with the desired mixture of particulate solid materials. Normally such a mixture is one which has been pregranulated and such differences as exist between conventional tab letting techniques lie primarily in the respective procedures used for preliminary processing of the mixture of particulate solid materials before they enter the die. Thus, when all the ingredients (including the active-matter) have good compression characteristics, one may be lucky enough to be able to adopt the simplest and cheapest of techniques known as "dry granulation", or a modified version thereof involving what is called "preliminary slugging". All too often, however, the compression characteristics of the mixture are so poor (a defect attributable usually to the nature and/or amount of active-matter present) that one is driven back as a last resort on the technique known as "wet-granulation". There is much art and skill in practising the "wet-granulation" technique; but, in outline, it involves no more than the incorporation of a granulating fluid into the mixed, powdery tablet ingredients (including at least some tabletting aids) in such an amount and manner as to convert them into a uniform, moist, coherent, non-pasty mass - which is at least essentially non-flowing - and which then is formed into moist granules of fairly uniform size, usually by forcing the mass through a screen. Thereafter the moist granules are dried and re-screened to break down agglomerates, and finally blended with other tabletting aids so as thus to arrive at the granulate ready for tabletting. It will be noted that in "wet-granulation" the tablet ingredients besides the active-matter also conventionally include other, pharmacologically-inert materials, certainly tabletting aids and perhaps also bulking agents. Some of such tabletting aids may be included in the mixed, powdery ingredients before the granulating fluid is incorporated therein, while further tabletting aids may be applied to the surfaces of the granules, and in between them, after the granules have been formed and before the granulate is passed to the tabletting machine. At this point it should be observed that when the amount of active-matter per tablet is small the pharmacologically-inert materials conventionally might well include what are here described as bulking agents, that is to say filler-type materials which serve no function except to bulk out the mixture so as to make tablets of adequate size; but that is not the kind of situation with which this invention is primarily concerned, and thus mere bulking agents are not intended to be included in the term "tabletting aids" as used herein. In the kind of situation in which one resorts to a "wet-granulation" technique, thus when the nature and/or amount of the active-matter causes the mixture to have poor compression characteristics, it will however usually be necessary to incorporate some appropriate amount of some or all of the conventional types of tabletting aids, namely binders, glidants, lubricants and disintegrants. Broadly-speaking: - binders are substances which help bind the particles of powder together in a form suited to compaction and compression; - glidants are substances which aid filling of the particles and/or granules into the die before compression; - lubricants are substances which help the compressed tablets to leave the die; and - disintegrants are substances which help the tablet to disintegrate, and perhaps dissolve, when it reaches its ultimate destination, usually within the body. Quite a variety of materials is available to serve each of these functions, some of them more effective than others. Sometimes a given material may be capable of simultaneously performing more than one function and, of course, all of them cannot help but bulk out the tabletting mixture, even though perhaps that may not be desired. It will, therefore, be appreciated that one cannot make any wholly-reliable predictions about the absolute and relative amounts of each individual binder and/or glidant and/or lubricant and/or disintegrant which should be present. In a successful formulation made by "wet-granulation" one can however as a generalization say that the overall requirement for all four types of tabletting aids will nearly always fall in the range of from 5% to 25% w/w, calculated relative to the weight of the final (dry) powder mass, and indeed the overall percentage of tabletting aids usually need not exceed say 15% w/w. Even using the conventional "wet-granulation" technique it is however not always possible to achieve a "successful" formulation, that is to say one which on compression of the granulate yields tablets which conform to accepted standards of appearance, hardness, fragility (or friability), disintegration and uniformity of weight, unless indeed the above-indicated overall percentage of tabletting aids is still further increased. The problem does not usually lie with the tabletting aids themselves, for these can be chosen at will from the well-tried array of such materials introduced over very many years, and can be relied upon to serve their function admirably, to the extent that they are not prevented from so doing by the nature of the active-matter. It is indeed the active-matter which is liable to cause tab letting problems, for here there is no freedom of choice - the tabletter must seek to incorporate in his tablet whatever active-matter the clinician wants - if possible in an amount which represents a unit dose suitable at one administration. While some kinds of active-matter, at least when present in moderate proportions, will lend themselves readily to compression and compaction into good-quality tablets when accompanied only by conventional proportions of tabletting aids, others will not. Furthermore, as new kinds of active-matter are introduced which have poor compression characteristics and/or as the clinician seeks to prescribe higher dosage levels of existing kinds of "poorly-compressible" active-matter, the tabletter is faced with fresh problems, sometimes very difficult or indeed impossible to solve within the confines of a single tablet. Where high-dosage activematter (or mixtures thereof) with poor compression characteristics must be incorporated into a single tablet, even conventional wet-granulation techniques using normal levels of tabletting aids prove inadequate to resolve these problems; yet if one uses still higher levels of tabletting aids, that may well result in a mixture of such bulk volume that the required weight is difficult or impossible to accommodate within the compression die cavity. However, even if the mixture can be so accommodated and tablets compressed, the tablets then may be of such a large size that they are difficult to swallow. It is the problem of tabletting such poorlycompressible kinds of active-matter, and especially those which are clinically-prescribed at high-dosage levels, which we have tackled. In our investigation of that problem we have been led to question hithertoprevailing assumptions concerning the procedures employed in the formation of tablets, with the aim of finding some way of making good-quality tablets even from poorly-compressible kinds of active-matter which tablets however contain no more than the unavoidable proportion of tabletting aid(s) necessarily present in "successful" conventional formulations based on easilycompressible active matter. We have now found surprisingly that by employing a modified version of conventional "wet-granulation", which for convenience we term "slurry granulation", we can provide a process for manufacturing tablets which goes at least some way to achieve this much-desired goal. Accordingly, the present invention provides a process for preparing a granulate suitable for use in manufacturing tablets by compressing and compacting a said granulate, which process comprises forming an intimate mixture of particulate-solid materials including active-matter and tabletting aids, as well as optionally other pharmacologically-inert material(s), thereafter "wet-granulating" said mixture by moistening it with substantially non-solvent (as hereinafter defined) granulating fluid(s) to form a substantiallyuniform, moist, coherent, non-pasty mass which finally is granulated (i.e. subdivided into individual granules) and dried, the dried granules (optionally after adding further tab letting aids thereto) constituting a granulate ready for compression and compaction into tablets, the process including the steps of: : (A) predetermining a quantity of granulating fluid(s) needed to convert the entire particulate-solid mixture into a desired moist, coherent, non-pasty mass; (B) homogenizing part only of the particulatesolid material(s), separately from the remainder thereof, with a chosen amount of granulating fluid(s), that chosen amount being at least 90% by weight of the aforesaid predetermined quantity of granulating fluid(s), so as to form a substantially-homogeneous slurry wherein the percentage by weight of solids in the slurry, namely: Total Solids, both dissolved and undissolved x 100 Total Slurry, i.e. fluids plus total solids is at least about 258 w/w, preferably at least about 30% w/w; and (C) moistening the remaining part of the particulate-solid material(s) in the manner of "wetgranulation" but with the slurry resultant from step (B) above (and thereafter as necessary with the balance of the granulating fluid(s), if any) so as thus to form a desired, substantially-uniform, moist, coherent, nonpasty mass ready for granulation. It will be seen that the process of this invention involves separately homogenizing part of the particulate-solid material(s) with the granulating fluid(s) to form a substantially-homogeneous slurry which is then used to moisten the remainder otherwise in the manner of conventional "wet-granulation". While it is at present impossible for us definitely to say why this technique should enable lesser proportions of tab letting aids to be satisfactorily employed than would be needed in a fully-conventional "wet-granulation", we are inclined to think that homogenization of part of the ingredients must somehow contribute to an "improvement" of the compression-characteristics of the material in the slurry. It is reasonable to suppose that the overall compression-characteristics of any granulate must partly depend upon the compression-characteristics of each of its ingredients, but which may operate via more than one mechanism. Poorly-compressible materials quite often have relatively fine particle sizes, and thus form low bulk-density "flocculent" powders, wherein a proportion of the particles are aggregated into multiparticle clumps. Therefore, one may speculate that homogenization perhaps tends to reduce the proportion of multi-particle clumps, and/or to ensure that substantially all of the particles are properly wetted with the granulating fluid. These, however, are only suppositions, and we do not desire to be limited by any theoretical considerations, preferring in the present uncertain state of our knowledge simply to observe that our new "slurry-granulation" process works in situations where the conventional "wet-granulation" process does not. It is convenient here to observe the term "active-matter" is used throughout this specification in a broad sense which encompasses whatever the manufacturer may wish to characterize his tablets, thus for instance including either sweetening and flavouring agents in the case of confectionary products or dietary aids both of the assimilable and of the nonassimilable kind. The invention, however, is primarily concerned with active-matter which consists of one or more pharmacologically-active substances. The predetermined "total" amount of granulating fluid to be employed (either in the granulating slurry as such, or otherwise) obviously must not exceed that needed to achieve the desired moist, coherent but nonpasty mass. When that amount (which, as known to skilled tabletters, is partly dependent on the type and scale of equipment used, as well as upon the degree of mechanical working imposed upon the mix during its preparation and subsequent screening) is exceeded, then the mixture will clog during screening to form the moist granules. Equally, however, the predetermined "total" amount of granulating fluid to be employed cannot be less than the amount needed to achieve the desired moist, coherent, non-pasty mass. Predetermination of the total quantity of granulating fluid(s) needed to convert the entire particulate-solid mixture into a desired substantiallyuniform, moist, coherent, non-pasty mass can and indeed initially will be achieved empirically, as is always the case in conventional procedures. A skilled operative is usually able to make an intelligent guess at the approximate quantity of granulating fluid(s) which will be required; but the exact amount is found by trial, adding a little at a time until the desired effect is achieved. Of course, the proper quantity of granulating fluid(s) having once been determined for a certain mixture of ingredients it will not always be necessary to redetermine it subsequently. Repetition of the process in the same manner on the same batch-size of the same ingredients will require essentially the same, already predetermined quantities of granulating fluid(s). In such situations step (1) of the process of this invention becomes notional rather than actual but, even if only notionally, it does for all that form part of the process. In passing it should be noted that the quantity of granulating fluid(s) required will of course be dependent, as in conventional "wetgranulation", upon the nature of the ingredients in the powdery mixture to be granulated, upon the parameters of the mixing procedure employed, and upon the kind of moist, coherent, non-pasty mass required. As general guidance it can be said that the total amount of granulating fluid(s) predetermined for use according to the present invention, although not necessarily exactly identical, will nevertheless be much the same as the amount needed to moisten the same mass using the conventional "wet-granulation" technique. However, the exact amount of granulating fluid to be employed is a matter which can and indeed must ultimately be left, as in conventional wet-granulation techniques, to the skill and judgment of the operative seeking to achieve the desired characteristics in the granulate and tablets compressed therefrom. The homogenization of the particulate-solid material(s) with the granulating fluid(s) must, as indicated above, be carried out in such a way as to form a substantially-homogeneous slurry, that is to say a flowable suspension (having the specified, relatively high percentage w/w of solids) which shows no obvious externally-visible sign of segregation over the longest period encountered as an acceptable delay in manufacturing procedures, thus in the course of a few hours, preferably not more than 2 hours. In everyday terms, one seeks a suspension with something akin to the consistency and stability of cream. That kind of suspension may be achieved in any convenient manner, but in our experience is best prepared by means of a highshear homogenizer. We do not exclude the possihility that the part of the particulate-solid material(s) which is to be slurried with granulating fluid(s) can be any part thereof, thus some or all of any of the individual ingredients, or even just some of the entire unsegregated mixture. However, we have found empirically that the best results seem to be obtained when the material which is slurried is at least mostly activematter. This ties in with our tentative supposition that homogenization somehow "improves" the compressioncharacteristics of the material being slurried because, as previously explained, the tabletting aids have already been selected for their beneficial effect upon the compression-characteristics of the granulate and need little improvement in this respect, but the compression-characteristics of the active-matter often leave much to be desired. As a rule of thumb it seems to be the case that the part of the particulate-solid materials which is homogenized with the chosen amount of granulating fluid(s) should contain not more than 50% w/w, and usually in our experience not more than about 35% w/w, of the total active matter; but, on the other hand, we have found that generally-speaking the slurry should contain not less than 10% w/w and usually not less than about 15% w/w, of the total active matter. Taking a different approach, it also seems to be the case that the part of the particulate-solid materials which is homogenized with the chosen amount of granulating fluid(s) usually need not exceed 50% w/w of the total particulate-solid materials, and generally speaking need not be more than about 35% w/w; but, on the other hand, usually will not be less than 10% w/w, and often not less than about 15% w/w, of the total particulate-solid material. At this point it is appropriate to observe that the slurry granulation process of this invention naturally can be employed in the tabletting of any kind of active-matter, even easily-compressible kinds of active-matter. This slurry granulation process however has been developed by us with the particular objective of improving the tabletting of "poorly-compressible" active-matter, and it is there that it displays itself to best advantage. Regrettably, there is no universally-accepted definition or test which can be used to identify "poorly-compressible" material, but any experienced tabletter will intuitively recognize what we mean thereby. It is also appropriate here to observe that there is nothing which forbids the use of the slurry granulation process of this invention in the preparation of tablets containing only relatively low proportions of active-matter - but, again, the process has been developed by us with the particular objective of facilitating the preparation of tablets containing higher-than-usual proportions of active matter, and it is in that area that the process shows itself in the most advantageous light. By "higher-than-usual" proportions of active matter we choose, somewhat arbitrarily, to mean tabletting mixtures and tablets made therefrom wherein the proportion of active matter relative to the whole (dry) mixture is 80% w/w or more. While we do not go so far as to claim that it can always be achieved, we have found that using our slurry granulation process it is generally possible to form satisfactory tablets even from materials which are poorly-compressible and/or present in higher-thanusual proportions while utilizing the levels of tabletting aids which would conventionally be employed in "wet-granulation" yet which would fail to be sufficient with such materials were it not for the slurry granulation technique of this invention. Thus, with such materials the present process can employ from 5% to 25% w/w, and often only from 5% to 15% w/w, of tabletting aids overall; and within those overall ranges some or all of the following: - binders in the range of from 2% to 10% w/w; - glidants in the range of from 0.2% to 10% w/w; - lubricants in the range of from 0.2% to 4% w/w; and - disintegrants in the range of from 2% to 10% w/w. Clearly, the process of the invention displays its advantages most outstandingly when the active matter is poorly-compressible and needs (at least for some clinical purposes) to be present in higher-than-usual proportions. Examples of active matters which fall in this dual-problem category are for instance: (a) so-called nalidixic acid, that is to say 1ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3carboxylic acid; (b) so-called paracetamol, that is to say N-(4hydroxyphenyl)-acetamide, with or without, but especially with so-called methionine, that is to say 2 amino-4-(methylthio)-butyric acid; (c) so-called hexopal, that is to say myo-inositol hexa-3-pyridine-carboxylate; (d) so-called benorylate, that is to say 2 (acetyloxy) benzoic acid 4-(acetylamino) phenyl ester; and (e) so-called paracetamol methionate, that is to say N-acetyl-para-aminophenylN'acetylD, L-methionate, either alone. or in admixture with paracetamol. Besides the immediately obvious candidates for the slurry-granulation process of this invention which have been mentioned above there are of course others which suggest themselves such as the sulphonamides. The chosen amount of granulating fluid(s) used to form the slurry will be in the range of from 90% up to 100% by weight of the previously predetermined total quantity already discussed above. If there is any uncertainty about quite how much granulating fluid will be needed, then a little can be held back (thus not included in the slurry) to be added at discretion after the slurry has been incorporated into the mix. Except in that situation it is however preferred that the "chosen amount" should be substantially the same as the "predetermined-quantity"; because, for reasons which we do not at present fully understand, it does seem that in order to secure the maximum improvement in the compression characteristics of the final granulate it is desirable that the chosen amount of granulating fluid used in formation of the slurry should be substantially all of the predetermined quantity, so that the resultant slurry alone will be substantially sufficient to achieve the desired moist, coherent but non-pasty mass containing all of the necessary ingredients, without the need for any significant further addition of granulating fluid. Thus, it is preferred to use all or virtually all of the granulating fluid(s) to form the slurry. The lower end of the weight percentage of solids in the slurry, set at a minimum of about 25% w/w, is necessary to ensure that a sufficient proportion of the total particulate-solid material(s) undergoes the slurrying step. The upper end of the weight percentage of solids has no theoretical maximum, but is limited by the increasing practical difficulties of forming the slurry and of using it to moisten the particulate-solids mix as the percentage w/w of solids rises. Thus, generally one forms a slurry with as high a percentage w/w of solids as can conveniently be achieved and utilized. Usually, the percentage w/w of solids in the slurry will not exceed 80% w/w, and in our experience so far we have never significantly exceeded about 70%. Typically, we have found it both readily possible and entirely satisfactory to form and use a slurry having a percentage w/w of solids in the range of from 40% up to 60% w/w; and we prefer to aim at a percentage w/w of solids of around 50% w/w, thus say 50 + 5% by weight. The granulating fluid(s) used in the process of this invention to form the slurry and thereafter to moisten the mixture must, as previously indicated, be substantially non-solvent for the overwhelming proportion (at least 90% w/w, and usually 95% w/w or more) of the particulate-solid materials to be moistened thereby. That requirement however does not necessarilly mean that the granulating fluid(s) used in the process must be inherently non-solvent for all of the ingredients. On the contrary, it is indeed a possible and sometimes preferred feature of the process of this invention that the non-solvent granulating fluid should be or should include a liquid which inherently is a solvent for some of the ingredient(s), provided only that the inherently-solvent fluid is rendered substantially non-solvent by substantially saturating or even super-saturating it with that solute. Nevertheless it is in fact often quite desirable that the otherwise non-solvent granulating fluid should serve as a solvent for a minor proportion of the tabletting aid(s). Specifically, we have found it usually advantageous if at least part of the binding agent, and normally all of it, is dissolved in the granulating fluid(s) incorporated in the granulating slurry. Examples of such conventional binding agents include starch, soluble starch, gelatin, polyvinylpyrrolidone and/or cellulose derivative(s). Of all the various binding agents we have so far employed the best by far, possibly because of its wide-ranging solubility profile in readily-available liquids, has proved to be polyvinylpyrrolidone (PVP), which therefore we much prefer to employ - and desirably to dissolve in the continuous phase of the granulating slurry. It will of course be appreciated that, as in conventional practice, the granulating fluid(s) employed to form the granulating slurry can sometimes advantageously consist of or include a substantially non-toxic, organic liquid more volatile than water, and in that event the process should be carried out if appropriate under flame-proof conditions. In those cases where an ingredient or ingredients partly dissolve in the granulating fluid(s), it may be desirable or even sometimes preferred to include a crystal poison in the mixture which is processed. Thus, for example, lactose or more preferably sodium acetate may be included as a crystal poison. Dependent upon the nature of the various particulate-solid ingredients and other operating parameters, the granulating fluid(s) employed can be any of those used in conventional wet-granulation techniques. Thus, for instance, the granulating fluid can consist of water alone or it can include water; and/or it can consist of or include any one or more water-miscible relatively-volatile polar organic liquids for example, methanol, ethanol, isopropanol, acetone and/or methyl ethyl ketone; and/or it can consist of or include any one or more water-immiscible, relativelyvolatile organic liquids, for example, above all methylene chloride but also perhaps (subject to operational difficulties and dangers) chloroform or ether. When seeking to achieve one of the primary objectives of this invention, namely the preparation of tablets containing higher-than-usual proportions of active-matter, no mere bulking agents will be employed. There is, however, no other objection to the incorporation of bulking agents in the particulate-solid materials used in the process of this invention. Supposing that any such bulking agents are to be included those selected may of course be any of the conventional ones, chosen in accordance with prevailing practice, and thus will probably consist of or include one or more of the following, namely lactose, calcium phosphate, mannitol starch and/or soluble starch. After the remaining part of the particulate-solid material(s) has been uniformly moistened by means of the granulating slurry, the resultant moist, coherent, non pasty mass is broken down into moist granules in any conventional manner, usually by screening. The moist granules must then be dried. Drying can be effected by any convenient method, and various conventional drying techniques are available. We would ourselves suggest drying, for example, either in loosely-packed drying trays, or more conveniently in a fluidised-bed dryer. The process of this invention will normally include the step of blending the tabletting granules with one or more further tabletting aid(s) before compacting the granulate to form tablets in conventional tabletting machinery. These "post-granulation" tabletting aid(s) will usually consist of or include disintegrant(s) and/or lubricant(s). Such disintegrant(s) may consist of or include a component or mixture of components capable of imparting an effervescent character to the final tablet, but in that event all the parameters of the process must of course be chosen so as to form the final tablet without detriment to its desired effervescent character. This invention of course also extends to tabletting granulates and also tablets made therefrom whenever prepared in or by the process herein disclosed. In addition, the invention also provides a tablet of overall weight no more than about 1 g, which tablet comprises a unit dose of active matter of at least about 700 mg, the active matter being paracetamol together with methionine or paracetamol methionate, or paracetamol methionate alone, present in an amount of from 80 to 90% by weight, and the tablet having a hardness of from 7 to 15 kp, a friability of less than 2%, preferably less than 1% and affording a disintegration time of no more than 15 minutes, preferably from 5 to 15 minutes. In order that the invention may be more fully understood in all of its various aspects it will now be described in more detail, though only by way of illustration, with reference to the following specific Examples: EXAMPLE I - Preparation of Tablets Containing Paracetamol and DL-Methionine using Wholly-Aqueous Granulating Slurry Stage A: Preparation of Tabletting Mixture A tabletting mixture was formed by mixing together the ingredients which are listed in Table I below, in the absolute and proportionate amounts also shown in Table I, by means of the procedure described subsequently herein: Table I EMI17.1 <tb> <SEP> Ingredients <SEP> Total <SEP> Amount <tb> <SEP> Quantity <SEP> in <tb> <SEP> in <SEP> grams <SEP> Slurry <tb> ACTIVE-MATTER <tb> DL-Methionine <SEP> 250 <SEP> 125 <tb> Paracetamol <SEP> 500 <SEP> <tb> (Sub-Total <SEP> of <SEP> Active <SEP> Matter) <SEP> (750) <SEP> (125) <tb> TABLETTING <SEP> AIDS <tb> Polyvinylpyrrolidone <SEP> 30 <SEP> 30 <tb> Stearic <SEP> acid <SEP> 10 <SEP> <tb> Sodium <SEP> starch <tb> glycollate <SEP> 50 <SEP> <tb> (Sub-Total <SEP> of <SEP> Tabletting <SEP> Aids) <SEP> (90) <SEP> (30) <tb> TOTAL: <SEP> 840 <SEP> 155 <tb> Granulating <SEP> Fluid <SEP> Water:200mls <SEP> 200 <tb> Stage B: Preparation of the Granulate. The procedure used for the preparation of the granulate from the above-listed ingredients was as follows: Preparation of the Slurry The polyvinylpyrrolidone (30 grams) was dissolved in 200 mls of water. Half of the DL-methionine (i.e. 125 grams) was suspended therein by means of a highshear homogenizer to form a stable dispersion having a cream-like consistency, which was used as the granulating slurry in the manner described below. Preparation of the Moist Mass: The remainder of the DL-methionine (i.e. 125 grams) was mixed with the paracetamol (500 grams) and half the sodium starch glycollate (25 grams) in a conventional mixer-granulator. The mixture was then wet-granulated until suitably massed in an otherwise conventional manner except that as granulating fluid there was used the granulating slurry prepared as described in Stage A above. Preparation of the Granules: The resultant moist, coherent, non-pasty granulate was screened through a 4-mesh sieve, and dried in a fluidized-bed drier at a temperature of from about 500 to 600C until a moisture-content of less than 2% had been achieved. The resulting dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates and then blended with stearic acid (10 grams) and the remainder of the sodium starch glycollate (25 grams) to form the final granulate ready for tabletting. Stage C: Preparation of Tablets The free-flowing tabletting granulate prepared as described in Stage B above was fed into a suitable conventional tablet-press, and compacted thereby into tablets which had an overall weight of approximately 840 mg each. Despite the fact that paracetamol is poorlycompressible and DL-methionine still more so, yet these were together present to an extent of nearly 90% w/w, with only about 10.7% of tabletting aids and no mere bulking agents. Furthermore, these tablets were found to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight. 0-0-0-0-0-0-0-0 EXAMPLE 2: Preparation of Tablets containing Paracetamol and Methionine, using Non-Aqueous or Semi Aqueous Granulating Fluids Stage A: Choice of Ingredients of Mixture A tabletting mixture was formed, by the procedure described below, from the ingredients listed together with their absolute and proportionate amounts in Table II as follows: Table II EMI19.1 <tb> Ingredients <SEP> Quantity <SEP> in <SEP> Amount <SEP> in <tb> <SEP> Mixture <SEP> (grams) <SEP> Slurry <SEP> (grams) <tb> ACTIVE <SEP> MATTER <tb> DL-Methionine <SEP> 250 <SEP> 125 <tb> Paracetamol <SEP> 500 <tb> (Sub-Total <SEP> of <tb> Active <SEP> Matter) <SEP> (750) <SEP> (125) <tb> TABLETTING <SEP> AIDS: : <tb> Sodium <SEP> starch <tb> glycollate <SEP> 50 <tb> Stearic <SEP> acid <SEP> 10 <tb> Polyvinylpyrrolidone <SEP> 30 <SEP> 30 <tb> (Sub-Total <SEP> of <tb> Tabletting <SEP> Aids) <SEP> (90) <SEP> (30) <tb> TOTALS: <SEP> 840 <SEP> 155 <tb> Granulating <SEP> Fluid <SEP> Water <SEP> and <tb> <SEP> various <SEP> 200mls <SEP> 200 <SEP> (water) <tb> <SEP> Isopropanol/ <tb> <SEP> Water <SEP> mixtures <tb> Stage B1: Preparation of Comparative Granulate by Conventional 'Wet Granulation' A preliminary run, using the above-listed ingredients in a standard mixer-granulator, established that approximately 200 mls of water (containing the polyvinylpyrrolidone) added as granulating fluid in the conventional manner were needed to obtain the desired moist, coherent, non-pasty mass suitable for granulation. The mass was then granulated by screening and drying in a fully conventional manner. Stage B2: Preparation of Granulate by'Slurry Granulation' in accordance with the present invention Using a standard mixer-granulator, the abovelisted ingredients were brought together in the following manner: Preparation of the Slurry: The polyvinylpyrrolidone (30 grams) was dissolved in the predetermined amount, namely 200 mls, of one of the following granulating fluid systems: - (a) isopropanol: - (b) a mixture (80:20 v/v) of isopropanol and water: - (c) a mixture (60:40 v/v) of isopropanol and water: - (d) a mixture (40:60 v/v) of isopropanol and water: and - (e) a mixture (20:80 v/v) of isopropanol and water. Dissolution was carried out at room temperature under flame-proof conditions, since the flashpoint of isopropanol is only 550F (about 130C). Under the same conditions, half of the DLmethionine (i.e. 125 grams) was suspended therein by means of a high-shear homogenizer to form a stable dispersion having a cream-like consistency, which was used in the manner described below as a granulating slurry in the formation of granulate. Preparation of the Moist Mass: The remainder of the DL-methionine (125 grams) was mixed with all the paracetamol (500 grams) and half of the sodium starch glycollate (25 grams) in a conventional mixer-granulator. The dry mixture was then wet-granulated until suitably massed in an otherwise conventional manner except that as the granulating fluid for that purpose there was used the granulating slurry prepared as described above. Preparation of the Granules: The resultant moist, coherent, non-pasty granulate was screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperature of about 400C for a period of about 20 minutes until the odour of isopropanol had disappeared. The resultant dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates and then blended with the stearic acid (10 grams) and the remainder of the sodium starch glycollate (25 grams) so as to form the final granulate. Stage C1: Preparation of Comparative Tablets. The granulate prepared as described in Stage B1 above was compressed into approximately 840 mg tablets upon a suitable conventional rotary tab letting machine. The resultant tablets were however unsatisfactory, due to major problems with the flow of the granulate into the dies and of lamination or splitting of the compressed tablets. Stage C2: Preparation of Tablets according to this invention. The granulate prepared as described in Stage B2 above was fed to the same conventional rotary tabletting machine, and there compressed to form approximately 840 mg tablets. These were found to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight. -0-0-0-0-0-0 EXAMPLE 3: Preparation of Tablets containing both Paracetamol and Paracetamol Methionate using Methanol as the Granulating Fluid Stage A: Preparation of Tabletting Mixture. A tabletting mixture was formed by mixing together the ingredients which are listed in Table III below, in the absolute and proportionate amounts also shown in Table III, by means of the procedure described subsequently herein: Table III EMI22.1 <SEP> Ingredients <SEP> Quantity <SEP> in <SEP> Amount <SEP> in <tb> <SEP> Whole <SEP> Mixture <SEP> Slurry <tb> <SEP> (grams) <SEP> (grams) <tb> <SEP> ACTIVE <SEP> MATTER: <tb> Paracetamol <tb> <SEP> methionate <SEP> 428 <SEP> 55 <tb> <SEP> Paracetamol <SEP> 400 <SEP> 50 <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Active <SEP> Matter <SEP> (828) <SEP> (105) <tb> <SEP> TABLETTING <SEP> AIDS: : <tb> <SEP> Sodium <SEP> starch <SEP> 100 <SEP> <tb> <SEP> glycollate <tb> <SEP> Magnesium <tb> <SEP> stearate <SEP> 8 <SEP> <SEP> Polyvinylpyrrolidone <SEP> 50 <SEP> 50 <tb> <SEP> Sodium <SEP> lauryl <tb> <SEP> sulphate <SEP> 2 <SEP> <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Tabletting <SEP> Aids) <SEP> (160) <SEP> (50) <tb> <SEP> TOTALS: <SEP> 988 <SEP> 155 <tb> <SEP> Granulating <SEP> Fluid: <SEP> Methanol:300 <SEP> mls <SEP> 237.7 <tb> Stage B1: Preparation of Comparative Granulate by Conventional Moist Granulation A preliminary run, using the above-listed ingredients (excepting 50 grams of the sodium starch glycollate, 8 grams of magnesium stearate and 2 grams of sodium lauryl sulphate) in a standard mixer-granulator established that approximately 300 mls of methanol (containing the polyvinylpyrrolidone) added as granulating fluid in the conventional manner were needed to obtain the desired moist, coherent, non-pasty mass suitable for granulation. The mass was then granulated by screening and drying in a fully conventional manner. Stage B2: Preparation of Granulate in accordance with this invention Using a standard mixer-granulator, the abovelisted ingredients were brought together in the following manner: Preparation of the Slurry The polyvinylpyrrolidone (50 grams) was dissolved in the full amount of methanol predetermined in Stage B1 above, namely 300 mls. Dissolution was carried out at room temperature under flame-proof conditions, since the flashpoint of methanol is only 540F (about 130C). Under the same conditions, a proportion of both the paracetamol methionate (i.e. 55 grams) and the paracetamol (i.e. 50 grams) was suspended in the PVPcontaining methanol by means of a high-shear homogenizer, to form a stable dispersion having a creamlike consistency, which was used in the manner described below as a granulating slurry in the formation of granulate. Preparation of the Moist Mass The remainder of the paracetamol methionate (i.e. 373 grams) was mixed with the remainder of the paracetamol (350 grams) and half of the sodium starch glycollate (50 grams) in a conventional mixergranulator, and this dry mixture was wet-granulated (under flame-proof conditions) until suitably massed in a conventional manner except that as the granulating fluid there was used the granulating slurry prepared as described above. Preparation of the Granules The resultant moist, coherent, non-pasty mass was screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperature of about 400C until the odour of methanol had disappeared. The resultant dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates. They were then blended with the remainder of the sodium starch glycollate (50 grams), with the sodium lauryl sulphate (2 grams) and with the magnesium stearate (8 grams) so as to form the final granulate ready for tabletting. Stage C1: Preparation of Comparative Tablets The granulate prepared as described in Stage B1 above was compressed into approximately 988 mg tablets upon a conventional rotary tabletting machine. The resultant tablets were however unsatisfactory, due to flow and lubrication problems with the granulate, and to lamination of the tablets. Stage C2: Preparation of Tablets according to this invention The free-flowing tabletting granulate prepared as described in Stage B2 above was fed into the same rotary tabletting machine. The granulate was compacted thereby into tablets which had an overall weight of approximately 988 mg each, and which were found (despite the fact that they contained only approximately 16% of tabletting aids) to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight. Typical results which may be obtained using procedures and compositions as described above for Examples 1 and 3 are as follows: TABLE A EMI25.1 Type <SEP> of <SEP> composition <SEP> Appearance <SEP> Hardness <SEP> (Kp) <SEP> Disintegration <SEP> Friability <tb> <SEP> time <SEP> (minutes) <tb> Example <SEP> 1 <SEP> Satisfactory <SEP> 11 <SEP> to <SEP> 13 <SEP> 11 <SEP> to <SEP> 13 <SEP> Satisfactory <tb> <SEP> i.e. <SEP> less <SEP> than <SEP> 1% <tb> Example <SEP> 1 <SEP> " <SEP> 8 <SEP> 5 <SEP> " <tb> Example <SEP> 1 <SEP> " <SEP> 15 <SEP> 12.5 <SEP> " <tb> Example <SEP> 3 <SEP> " <SEP> 14 <SEP> to <SEP> 15 <SEP> 4 <SEP> to <SEP> 10 <SEP> " <tb> EXAMPLE 4: Preparation of Tablets containing Benorylate using either Ethanol or Water as the Granulating Fluid in the Granulating Slurry Stage A: Preparation of Tabletting Mixture A tabletting mixture was formed by mixing together the ingredients which are listed in Table IV below, in the absolute and proportionate amounts also shown in Table IV, by means of the procedure described subsequently herein: Table IV EMI27.1 <tb> Ingredients <SEP> Quantity <SEP> in <SEP> @ <SEP> <SEP> Amount <SEP> in <tb> <SEP> Whole <SEP> Mixture <SEP> Slurry <tb> <SEP> (grams) <SEP> (grams) <tb> ACTIVE <SEP> MATTER: <tb> Benorylate <SEP> 750 <SEP> 250 <tb> (Sub-Total <SEP> of <tb> Active <SEP> Matter) <SEP> @ <SEP> (750) <SEP> (250) <tb> TABLETTING <SEP> AIDS: : <tb> Polyvinylpyrrolidone <SEP> @ <SEP> 18.75 <SEP> 18.75 <tb> Potassium <SEP> sorbate <SEP> 0.75 <SEP> 0.75 <tb> Maize <SEP> starch <SEP> 23 <tb> Sodium <SEP> starch <tb> glycollate <SEP> 21.75 <tb> Magnesium <SEP> stearate <SEP> @ <SEP> 3.75 <tb> (Sub-Total <SEP> of <tb> Tabletting <SEP> Aids) <SEP> (68) <SEP> (19.5) <tb> TOTAL: <SEP> 1 <SEP> 818 <SEP> 269.5 <tb> Granulating <SEP> Fluid: <SEP> Ethanol:350 <SEP> mls <SEP> 285.6 <tb> Stage B: Preparation of the Granulate The procedure used for the preparation of the granulate from the above-listed ingredients was as follows: Preparation of the Slurry The polyvinylpyrrolidone (18.75 grams) and the potassium sorbate (0.75 grams) were dissolved in ethanol (350 ml). One third of the benorylate (250 grams) was then suspended in the ethanolic solution by means of a high-shear homogenizer, to form a stable dispersion having a cream-like consistency, which is used as the granulating slurry in the manner described below. Preparation of the Moist Mass The remainder of the benorylate (500 grams) was mixed with the maize starch (23 grams) in a conventional mixer-granulator. The mixture was then wet-granulated until suitably massed in an otherwise conventional manner except that as granulating fluid there was used the granulating slurry prepared as described above. Preparation of the Granulate The resultant moist, coherent, non-pasty granules were screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperature of from 400 to 500C until the odour of ethanol had disappeared. The resultant dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates. They were then blended with sodium starch glycollate (21.75 grams) and magnesium stearate (3.75 grams) so as to form the final granulate. Stage C: Preparation of Tablets according to this invention The free-flowing tabletting granulate, prepared as described in Stage B above, was fed into a conventional rotary tabletting machine, and compressed to form approximately 818 mg caplets. These were found to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight. -0-0-0-0-0 - The same procedure utilizing water (350 ml = 350 grams) as the granulating fluid instead of ethanol, and drying the granules to a moisture content of less than 2%, yielded equally satisfactory caplets. EXAMPLE 5: Preparation of Tablets containing Nalidixic Acid, using Isopropanol or Ethanol or Aqueous (50:50) Mixtures thereof as the Granulating Fluid in the Granulating Slurry Stage A: Preparation of Tabletting Mixture A tabletting mixture was formed by mixing together the ingredients which are listed in Table V below, in the absolute and proportionate amounts shown in Table V, by means of the procedure described subsequently herein: Table V EMI30.1 <tb> Ingredients <SEP> Quantity <SEP> in <SEP> Amounts <tb> <SEP> Whole <SEP> Mixture <SEP> in <SEP> Slurry <tb> <SEP> (grams) <SEP> I <SEP> (grams) <tb> ACTIVE <SEP> MATTER: <tb> Nalidixic <SEP> acid <SEP> 500 <SEP> 165 <tb> (Sub-Total <SEP> of <tb> Active <SEP> Matter) <SEP> (500) <SEP> (165) <tb> TABLETTING <SEP> AIDS: : <tb> Polyvinylpyrrolidone <SEP> 37 <SEP> 37 <tb> Maize <SEP> starch <SEP> 138 <tb> Dicalcium <SEP> phosphate <SEP> 100 <tb> Magnesium <SEP> stearate <SEP> 2 <tb> (Sub-Total <SEP> of <tb> Tabletting <SEP> Aids) <SEP> (277) <SEP> (37) <tb> TOTALS: <SEP> 777 <SEP> 202 <tb> Granulating <SEP> Fluid: <SEP> -- <SEP> Isopropanol:200 <SEP> mls <SEP> 157 <tb> Stage B: Preparation of the Granulate The procedure used for the preparation of the granulate from the above-listed ingredients was as follows: Preparation of the Slurry The polyvinylpyrrolidone (37 grams) was dissolved in the isopropanol (200 mls = 157 grams). About onethird of the nalidixic acid (165 grams) was then suspended in the isopropanol solution by means of a high-shear homogenizer, to form a stable dispersion having a cream-like consistency, which was used as the granulating slurry in the manner described below. Preparation of the Moist Mass The remainder of the nalidixic acid (335 grams) was mixed with the maize starch (138 grams) and the dicalcium phosphate (100 grams) in a conventional mixergranulator. The mixture was then wet-granulated until suitably massed in an otherwise conventional manner except that as the granulating fluid there was used the granulating slurry prepared as described above. Preparation of the Granulate The resultant moist, coherent, non-pasty granules were screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperature of from about 500 to 600 until the odour of isopropanol could no longer be detected. The resultant dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates. They were then blended with the magnesium stearate (2 grams) so as to form the final granulate. Stage C: Preparation of Tablets according to this invention The free-flowing tabletting granulate, prepared as described in Stage B above was fed into a conventional rotary tabletting machine, and compressed to form both approximately 777 mg tablets and approximately 777 mg caplets. These were found to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight. -0-0-0-0-0 The same procedure yielded equally satisfactory tablets and caplets when instead of isopropanol there was emloyed as the granulating fluid the same volume of ethanol (156 grams) or of aqueous (50:50) isopropanol (178.5 grams) or of aqueous (50:50) ethanol (178 grams). EXAMPLE 6: Preparation of Tablets containing Hexopal using Ethanol as the Granulating Fluid in the Granulating Slurry A tabletting mixture was formed by mixing together the ingredients which are listed in Table VI below, in the absolute and proportionate amounts also shown in Table VI, by means of the procedure described subsequently herein: Table VI EMI32.1 <tb> <SEP> Ingredients <SEP> Quantity <SEP> in <SEP> Amounts <SEP> in <tb> <SEP> Whole <SEP> Mixture <SEP> 1 <SEP> Slurry <tb> <SEP> (grams) <SEP> (grams) <tb> <SEP> ACTIVE <SEP> MATTER: <tb> <SEP> meso-Inositol <tb> <SEP> hexanicotinate <SEP> 1000 <SEP> 300 <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Active <SEP> Matter) <SEP> (1000) <SEP> (300) <tb> <SEP> TABLETTING <SEP> AIDS: : <tb> <SEP> Polyvinylpyrrolidone <SEP> 50 <SEP> 50 <tb> <SEP> Maize <SEP> starch <SEP> 75 <tb> Sodium <SEP> lauryl <tb> <SEP> |sulphate <SEP> 10 <SEP> ¯ <SEP> ! <SEP> <tb> <SEP> Magnesium <SEP> stearate <SEP> 8 <SEP> <SEP> - <SEP> <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Tabletting <SEP> Aids) <SEP> (143) <SEP> (50) <tb> <SEP> TOTALS: <SEP> 1143 <SEP> 350 <tb> <SEP> Granulating <SEP> Fluid: <SEP> Ethanol: <SEP> 300 <SEP> mls <SEP> 240 <tb> Stage B: Preparation of the Granulate The procedure used for the preparation of the granulate from the above-listed ingredients was as follows: Preparation of the Slurry The polyvinylpyrrolidone (50 grams) was dissolved in the ethanol (300 ml = 240 grams). Roughly a third of the meso-inositol hexanicotinate (300 grams) was then suspended in the ethanolic solution by means of a highshear homogenizer, to form a stable dispersion having a cream-like consistency, which was used as the granulating slurry in the manner described below. Preparation of the Moist Mass The remainder of the meso-inositol hexanicotinate (700 grams) was then placed in a conventional mixergranulator and wet-granulated until suitably massed in an otherwise conventional manner except that as the granulating fluid there was used the slurry prepared as described above. Preparation of the Granulate The resultant moist, coherent, non-pasty granules were screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperataure of from about 500 to 600C until the odour of ethanol could no longer be detected. The resultant dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates. They were then blended with the maize starch (75 grams), the sodium lauryl sulphate (10 grams) and the magnesium stearate (8 grams) so as to form the final granulate. Stage C: Preparation of Tablets according to this invention The free-flowing tabletting granulate, prepared as described in Stage B above, was fed into a conventional rotary tabletting machine, and compressed to form approximately 1143mg caplets. These were found to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight. -0-0-0-0-0 EXAMPLE 7: Alternative Preparation of Tablets containing both Paracetamol and Paracetamol Methionate using Methanol as the Granulating Fluid Stage A: Preparation of Tabletting Mixture A tabletting mixture was formed by mixing together the ingredients which are listed in Table VII below, in the absolute and proportionate amounts shown in Table VII, by means of the procedure described subsequently herein: Table VII EMI35.1 <tb> Ingredients <SEP> Quantity <SEP> in <SEP> Amount <SEP> in <tb> <SEP> Whole <SEP> Mixture <SEP> Slurry <tb> <SEP> (grams) <SEP> (grams) <tb> ACTIVE <SEP> MATTER: <tb> Paracetamol <tb> methionate <SEP> 428 <SEP> 55 <tb> Paracetamol <SEP> 400 <SEP> 50 <tb> (Sub-Total <SEP> of <tb> Active <SEP> Matter <SEP> (828) <SEP> (105) <tb> TABLETTING <SEP> AIDS: : <tb> Sodium <SEP> starch <tb> glycollate <SEP> 100 <SEP> <tb> Magnesium <SEP> stearate <SEP> 8 <SEP> <tb> Polyvinylpyrrolidone <SEP> 50 <tb> Sodium <SEP> lauryl <SEP> sulphate <SEP> 2 <tb> (Sub-Total <SEP> of <tb> Tabletting <SEP> Aids) <SEP> (160) <SEP> (N <SEP> I <SEP> L) <tb> TOTALS: <SEP> 988 <SEP> 105 <tb> Granulating <SEP> Fluid: <SEP> Methanol: <SEP> 300 <SEP> mls <SEP> 237.7 <tb> Staqe B1: Preparation of Comparative Granulate by Conventional Moist Granulation A preliminary run, using the above-listed ingredients (excepting 50 grams of the sodium starch glycollate, 8 grams of magnesium stearate and 2 grams of sodium lauryl sulphate) in a standard mixer-granulator established that approximately 300 mls of methanol added as granulating fluid in the conventional manner were needed to obtain the desired moist, coherent, non-pasty mass suitable for granulation. The mass was then granulated by screening and drying in a fully conventional manner. Stage B2: Preparation of Granulate in accordance with this invention Using a standard mixer-granulator, the abovelisted ingredients were brought together in the following manner: reparation of the Slurry Working under flame-proof conditions at room temperature, since the flashpoint of methanol is only 540F (about 130C), a proportion of both the paracetamol methionate (i.e. 55 grams) and the paracetamol (i.e. 50 grams) was suspended in the full amount of methanol predetermined in Stage B1 above, namely 300 mls, by means of a high-shear homogenizer, to form a stable dispersion having a cream-like consistency That dispersion was then used in the manner described below as a granulating slurry in the formation of granulate. Preparation of the Moist Mass The remainder of the paracetamol methionate (i.e. 373 grams) was mixed with the remainder of the paracetamol (350 grams), half of the sodium starch glycollate (50 grams) and all the polyvinylpyrrolidone (50 grams) in a conventional mixer-granulator, and this dry mixture was wet-granulated (under flame-proof conditions) until suitably massed in a conventional manner except that as the granulating fluid there was used the granulating slurry prepared as described above. Preparation of the Granules The resultant moist, coherent, non-pasty mass was screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperature of about 400C until the odour of methanol had disappeared. The resultant dried granules were re-screened through a 16mesh sieve to eliminate agglomerates; and they were then blended with the remainder of the sodium starch glycollate (50 grams), with the sodium lauryl sulphate (2 grams) and with the magnesium stearate (8 grams) so as to form the final granulate ready for tabletting. Stage C1: Preparation of Comparative Tablets The granulate prepared as described in Stage B1 above was compressed into approximately 988 mg tablets upon a conventional rotary tabletting machine. The resultant tablets were however unsatisfactory, due to flow and lubrication problems with the granulate and to lamination of the tablets. Stage C2: Preparation of Tablets according to this invention The free-flowing tabletting granulate prepared as described in Stage B2 above was fed into the same rotary tabletting machine. It was then compacted thereby into tablets which had an overall weight of approximately 988 mg, and which were found (despite the fact that they contained only approximately 16% of tabletting aids) to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight. -0-0-0-0-0-0 EXAMPLE 8: Preparation of Tablets containing Paracetamol using Water as the Granulating Fluid in the Granulating Slurry A tabletting mixture was formed by mixing together the ingredients which are listed in Table VIII below, in the absolute and proportionate amounts also shown in Table VIII, by means of the procedure described subsequently herein: Table VIII EMI38.1 <tb> <SEP> Ingredients <SEP> Quantity <SEP> in <SEP> Amounts <tb> <SEP> Whole <SEP> Mixture <SEP> in <SEP> Slurry <tb> <SEP> (grams) <SEP> (grams) <tb> <SEP> ACTIVE <SEP> MATTER: <tb> <SEP> Paracetamol <SEP> 500 <SEP> 150 <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Active <SEP> Matter) <SEP> (500) <SEP> (150) <tb> <SEP> TABLETTING <SEP> AIDS: : <tb> <SEP> Polyvinylpyrrolidone <SEP> 3 <SEP> 3 <tb> <SEP> Sorbitol <SEP> powder <SEP> 100 <SEP> 75 <tb> <SEP> Carbowax <SEP> 6000 <SEP> 12 <SEP> 12 <tb> <SEP> Stearic <SEP> acid <SEP> 4 <tb> <SEP> Talc <SEP> 20 <tb> Maize <SEP> starch <SEP> 17 <tb> <SEP> Soluble <SEP> starch <SEP> 35 <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Tabletting <SEP> aids) <SEP> (191) <SEP> (90) <tb> <SEP> TOTALS: <SEP> 691 <SEP> 240 <tb> <SEP> Granulating <SEP> Fludi: <SEP> Water <SEP> 100 <SEP> mls <SEP> 100 <tb> [Note: Carbowax 6000 is believed to be a mixture of polyethylene glycols and methoxypolyethylene glycols having an average molecular weight of approximately 6,000]. Stage B: Preparation of the Granulate The procedure used for the preparation of the granulate from the above-listed ingredients was as follows: Preparation of the Slurry The polyvinylpyrrolidone (3 grams) and threequarters of the sorbitol powder (75 grams) were dissolved in water (100 ml = 100 grams). Roughly a third of the paracetamol (150 grams) and the Carbowax 6000 (12 grams) were then suspended in the aqueous solution by means of a high-shear homogenizer, to form a stable dispersion having a cream-like consistency, which was used as the granulating slurry in the manner described below. Preparation of the Moist Mass The remainder of the paracetamol (350 grams) was mixed with the soluble starch (35 grams) and the rest of the sorbitol powder (25 grams) in a conventional mixergranulator. The mixture was then wet-granulated until suitably massed in an otherwise conventional manner except that as the granulating fluid there was used the granulating slurry prepared as described above. Preparation of the Granulate The resultant moist, coherent, non-pasty granules were screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperature of from 500 to 600C until the moisture level had droped below 2% w/w. The resultant dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates. They were then blended with the talc (20 grams), stearic acid (4 grams) and maize starch (17 grams) so as to form the final granulate. Stage C: Preparation of Tablets according to this invention The free-flowing tabletting granulate, prepared as described in Stage B above, was fed into a conventional rotary tabletting machine, and compressed to form one-half inch diameter tablets. These were found to conform to accepted standards of appearance, hardness, fragility -(friability) disintegration and uniformity of weight. -0-0-0-0-0-0 EXAMPLE 9 - Preparation of Caplets Containing Paracetamol and DL-Methionine using Wholly-Aqueous Granulating Slurry Stage A: Preparation of Tabletting Mixture A tabletting mixture was formed by mixing together the ingredients which are listed in Table IX below, in the absolute and proportionate amounts also shown in Table IX, by means of the procedure described subsequently herein: : Table IX EMI40.1 <tb> <SEP> Ingredients <SEP> Total <SEP> Amount <tb> <SEP> Quantity <SEP> in <tb> <SEP> in <SEP> grams <SEP> Slurry <tb> ACTIVE-MATTER <tb> <SEP> DL-Methionine <SEP> 250 <SEP> 125 <tb> <SEP> Paracetamol <SEP> 500 <tb> <SEP> (Sub-Total <SEP> of <SEP> Active <SEP> Matter) <SEP> (750) <SEP> (125) <tb> <SEP> TABLETTING <SEP> AIDS <tb> <SEP> Polyvinylpyrrolidone <SEP> 30 <SEP> 30 <tb> <SEP> Sodium <SEP> acetate <SEP> 13 <SEP> 13 <tb> <SEP> Stearic <SEP> acid <SEP> 10 <SEP> <SEP> - <SEP> <tb> <SEP> Sodium <SEP> Starch <tb> <SEP> Glycollate <SEP> 50 <SEP> <tb> <SEP> (Sub-Total <SEP> of <SEP> Tabletting <SEP> Aids) <SEP> (68 <SEP> ) <SEP> (43) <tb> <SEP> TOTAL: <SEP> 853 <SEP> 168 <tb> <SEP> Granulatin <SEP> Fluid <SEP> Water:85mls <SEP> 85 <SEP> rams <tb> Stage B: Preparation of the Granulate. The procedure used for the preparation of the granulate from the above-listed ingredients was as follows: Preparation of the Slurry The sodium acetate (13 grams) was dissolved in 85 mls of water and the polyvinylpyrrolidone (30 grams) was dissolved in the aqueous solution of sodium acetate. Half of the DL-methionine (i.e. 125 grams) was suspended in the thus-formed aqueous solution by means of a highshear homogenizer to form a stable dispersion having a cream-like consistency, which was used as the granulating slurry in the manner described below. Preparation of the Moist Mass: The remainder of the DL-methionine (i.e. 125 grams) was mixed with the paracetamol (500 grams) and half the sodium starch glycollate (25 grams) in a conventional mixer-granulator. The mixture was then wet-granulated until suitably massed in an otherwise conventional manner except that as granulating fluid there was used the granulating slurry prepared as described in Stage A above. (If required a small amount of additional water may be added to achieve the moistmass condition). Preparation of the Granules: The resultant moist, coherent, non-pasty granulate was screened through a 4-mesh sieve, and dried in a fluidized-bed drier at a temperature of about 6O0C until a moisture-content of 1.5% to 2% w/w had been achieved. The resulting dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates and then blended with stearic acid (10 grams) and the remainder of the sodium starch glycollate (25 grams) to form the final granulate ready for tabletting. Stage C: Preparation of Tablets The free-flowing tabletting granulate prepared as described in Stage B above was fed into a suitable conventional tablet-press fitted with caplet tooling, and compacted thereby into caplets which had an overall weight of approximately 853 mg each. Despite the fact that paracetamol is poorly-compressible and DLmethionine still more so, yet these were together present to an extent of nearly 88% w/w, with only about 12% of tabletting aids and no mere bulking agents. Furthermore, these caplets were found to conform to accepted standards of appearance, hardness, fragility (friability), disintegration and uniformity of weight as can be seen for three different batches from the results given in Table B below: TABLE B EMI42.1 Batch <SEP> Uniformity <SEP> of <SEP> Appearance <SEP> Hardness <SEP> (kp) <SEP> Disintegration <SEP> Fragility <tb> <SEP> Weight <SEP> time <SEP> (minutes) <SEP> (Friability) <tb> A <SEP> Satisfactory <SEP> Satisfactory <SEP> 14.7 <SEP> Satisfactory- <SEP> Satisfactory <SEP> <SEP> # <SEP> 5% <SEP> less <SEP> than <SEP> 15 <SEP> minutes <SEP> * <SEP> 0.05% <SEP> weight <SEP> loss <tb> B <SEP> " <SEP> " <SEP> 8.7 <SEP> " <SEP> Satisfacotory <SEP> <SEP> 0.12% <SEP> weight <SEP> loss <tb> C <SEP> " <SEP> " <SEP> 12.7 <SEP> " <SEP> Satisfactory <SEP> <SEP> 0.12% <SEP> weight <SEP> loss <tb> * British Pharmacopoeia Standard BP 1980 EXAMPLE 10: Preparation of Tablets containing both Paracetamol and Paracetamol Methionate using water as the Granulating Fluid Stage A: Preparation of Tabletting Mixture A tabletting mixture was formed by mixing together the ingredients which are listed in Table X below, in the absolute and proportionate amounts also shown in Table X, by means of the procedure described subsequently herein. Table X EMI44.1 <tb> I <SEP> Ingredients <SEP> Quantity <SEP> in <SEP> Amount <SEP> in <tb> <SEP> ole <SEP> Mixture <SEP> Slurry <tb> <SEP> (grams) <SEP> (grams) <tb> <SEP> ACTIVE <SEP> MATTER: <tb> <SEP> Paracetamol <tb> <SEP> methionate <SEP> 428 <SEP> i <SEP> 42.8 <tb> <SEP> Paracetamol <SEP> 400 <SEP> 40 <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Active <SEP> Matter) <SEP> (828) <SEP> (82.8) <tb> <SEP> TABLETTING <SEP> AIDS: <tb> <SEP> Sodium <SEP> starch <SEP> glycollate <SEP> 100 <tb> <SEP> Magnesium <SEP> stearate <SEP> 8 <tb> <SEP> Polyvinylpyrrolidone <SEP> 40 <SEP> 40 <tb> <SEP> Sodium <SEP> lauryl <SEP> sulphate <SEP> 10 <SEP> 10 <tb> <SEP> (Sub-Total <SEP> of <tb> <SEP> Tabletting <SEP> Aids) <SEP> (158) <SEP> (50) <tb> <SEP> TOTALS: <SEP> 986 <SEP> 132.8 <tb> <SEP> Granulating <SEP> Fluid: <SEP> 1 <SEP> Water: <SEP> 310 <SEP> mls <SEP> 310 <SEP> grams <tb> Stage B1: Preparation of Comparative Granulate by Conventional Moist Granulation A preliminary run, using the above-listed ingredients (excepting 50 grams of the sodium starch glycollate and 8 grams of magnesium stearate) in a standard mixer-granulator established that approximately 310 mls of water (containing the polyvinylpyrrolidone and sodium lauryl sulphate) added as granulating fluid in the conventional manner were needed to obtain the desired moist, coherent, non-pasty mass suitable for granulation. The mass was then granulated by screening and drying in a fully conventional manner. Stage B2: Preparation of Granulate in accordance with this invention. Using a standard mixer-granulator, the abovelisted ingredients were brought together in the following manner: Preparation of the Slurry The polyvinylpyrrolidone (40 grams) and sodium lauryl sulphate (10 grams) were dissolved in the full amount of water predetermined in Stage B1 above, namely 310 mls. Dissolution was carried out at room temperature and under the same conditions, a proportion of both the paracetamol methionate (i.e. 42.8 grams) and the paracetamol (i.e. 40 grams) was suspended in the PVPand sodium lauryl sulphate-containing water by means of a high-shear homogenizer, to form a stable dispersion having a cream-like consistency, which was used in the manner described below as a granulating slurry in the formation of granulate. Preparation of the Moist Mass The remainder of the paracetamol methionate (i.e. 385.1 grams) was mixed with the remainder of the paracetamol (360 grams) and half of the sodium starch glycollate (50 grams) in a conventional mixergranulator, and this dry mixture was wet-granulated until suitably massed in a conventional manner except that as the granulating fluid there was used the granulating slurry prepared as described above. Preparation of the Granules The resultant moist, coherent, non-pasty mass was screened through a 4-mesh sieve, and dried in a fluidized-bed air-drier at a temperature of about 550C to a moisture content of about 1.5% w/w. The resultant dried granules were re-screened through a 16-mesh sieve to eliminate agglomerates. They were then blended with the remainder of the sodium starch glycollate (50 grams) and with the magnesium stearate (8 grams) so as to form the final granulate ready for tabletting. Stage C1: Preparation of Comparative Tablets The granulate prepared as described in Stage B1 above was compressed into approximately 986 mg tablets upon a conventional rotary tabletting machine. The resultant tablets were however unsatisfactory, due to flow and lubrication problems with the granulate, and to lamination of the tablets. Stage C2: Preparation of Tablets according to this Invention The free-flowing tabletting granulate prepared as described in Stage B2 above was fed into the same rotary tabletting machine. The granulate was compacted thereby into tablets which had an overall weight of approximately 986 mg each, and which were found (despite the fact that they contained only approximately 16% of tabletting aids) to conform to accepted standards of appearance, hardness, fragility, (friability) disintegration and uniformity of weight.

Claims: CLAIMS 1. A process for preparing a granulate suitable for use in manufacturing tablets by compressing and compacting a said granulate, which process comprises forming an intimate mixture of particulate-solid materials including active matter, for example, one or more pharmacologically-active substances, and tabletting aids, as well as optionally other pharmacologicallyinert material(s), thereafter "wet-granulating" said mixture by moistening it with granulating fluid(s) to form a substantially-uniform, moist, coherent, non-pasty mass which finally is subdivided into individual granules and dried, for example, in a fluidized-bed drier, the dried granules (optionally after adding further tabletting aids thereto) constituting the desired granulate ready for compression and compaction into tablets, the process including the steps of: : (A) predetermining a quantity of granulating fluid(s) needed to convert the entire particulate-solid mixture into a desired moist, coherent, non-pasty mass; (B) homogenizing part only of the particulatesolid material(s), separately from the remainder thereof, with a chosen amount of granulating fluid(s), that chosen amount being at least 90%, and preferably 100%, by weight of the aforesaid predetermined quantity of granulating fluid(s), so as to form a substantiallyhomogeneous slurry wherein the percentage by weight of solids in the slurry, namely: Total Solids, i.e. both dissolved and undissolved x 100 Total Slurry, i.e. fluids plus total solids is at least about 25% w/w; and (C) moistening the remaining part of the particulate-solid material(s) in the manner of "wetgranulation" but with the slurry resultant from step (B) above (and thereafter as necessary with the balance of the granulating fluid(s), if any) so as thus to form a desired substantially-uniform, moist, coherent, nonpasty mass ready for granulation. 2. A process according to claim 1, in which the homogenization into the form of a slurry is performed by means of a high-shear homogenizer. 3. A process according to claim 1 or claim 2, in which that part of the particulate-solid materials which is homogenized with the chosen amount of granulating fluid(s) is or includes some or all of the activematter. 4. A process according to claim 3, in which that part of the particulate-solid materials which is homogenized with the chosen amount of granulating fluid(s) consists of or includes not more than 50% and not less than 10% by weight, and is preferably from 15% to 35% by weight, of the total active matter. 5. A process according to any of the preceding claims, in which that part of the particulate-solid materials which is homogenized with the chosen amount of granulating fluid(s) does not exceed 50% but is not less than 10% by weight, and is preferably from 15% to 35% by weight, of the total particulate-solid materials. 6. A process according to any of the preceding claims, in which that part of the particulate-solid materials which is homogenized with the chosen amount of granulating fluid(s) is or includes poorly-compressible active matter. 7. A process according to any of the preceding claims, in which the particulate-solid materials contain 80% w/w or more of active-matter. 8. A process according to claim 6 and/or claim 7, in which the total tabletting aid(s) incorporated in the granulate before compression into tablets amount to from 5% to 25% w/w, preferably from 5% to 15% w/w, overall calculated relative to the weight of the final dry mass and are, for example, some or all of the following: - binders in the range of from 2% to 10% w/w; - glidants in the range of from 0.2% to 10% w/w; - lubricants in the range of from 0.2% to 4% w/w; and - disintegrants in the range of from 2% to 10% w/w. 9. A process according to claim 6 and/or 7 and/or 8, in which the active matter homogenized is or includes one of the following, namely nalidixic acid, paracetamol with or without methionine, hexopal, benorylate and paracetamol methionate with or without paracetamol. 10. A process as claimed in any of the preceding claims, in which the percentage by weight of solids in the slurry does not exceed 80% w/w, preferably does not exceed 70% w/w, and more preferably is from 40% w/w up to 60% w/w, e.g. + 50% 5% w/w. 11. A process according to any of the preceding claims, in which the tabletting aids employed include a binding agent, for example, polyvinylpyrrolidone, at least part of which is dissolved in the granulating fluid(s) incorporated in the slurry. 12. A process according to any of the preceding claims, in which the granulating fluid(s) employed to form the granulating slurry consist of or include water and/or one or more substantially non-toxic, organic liquid(s) more volatile than water, for example, water and/or one or more water-miscible relatively-volatile polar organic liquids such as methanol, ethanol, isopropanol, acetone and/or methyl ethyl ketone; or one or more water immiscible relatively-volatile organic liquids, for example, methylene chloride, chloroform and/or ether. 13. A process according to any of the preceding claims, in which after the remaining part of the particulatesolid material(s) has been uniformly moistened by means of the granulating slurry, the resultant moist, coherent, non-pasty mass is broken down into moist granules by screening. 14. A granulate for use in manufacturing tablets by compression and compaction thereof whenever prepared by a process according to any of the preceding claims. 15. A process according to any of claims 1 to 13, which includes the further step, optionally after blending the dried granules with one or more further tabletting aids, of compacting the resultant granulate to form tablets of a predetermined tablet volume in tabletting machinery. 16. Tablets whenever manufactured by a process according to claim 15. 17. A tablet of overall weight no more than about 1 g, which tablet comprises a unit dose of active matter of at least about 700 mg, the active matter being paracetamol together with methionine or paracetamol methionate , or paracetamol methionate alone, present in an amount of from 80 to 90% by weight, the tablet having a hardness of from 7 to 15 kp, a friability of less than 2%, preferably less than I,and affording a disintegration time of no more than 15 minutes, preferably from 5 to 15 minutes.

Inventors: ROGERSON, ALAN GEORGE
Applicants: STERWIN AG.
Application year: 1983
Main classification: A61K9
IPC codes: A61K9