A NEW NEMATOCIDAL COMPOSITION, PROCESSES FOR ITS PRODUCTION AND ITS USE

Abstract: The invention relates to new nematocidal compositions consisting of one or more nematocidally active substances and one or more certain phospholipides in addition to stan­ dard vehicles, diluente, solvents and/or other inert auxilia­ ries, the ratio by weight of the nematocidally active sub­ stance or mixture of nematocidally active substances to pure phospholipide or to the mixture of pure phospholipides amounting to between 1 : 0.2 and 1 : 20. The invention also relates to processes for producing these compositions and to processes for controlling nematodes using the new ne­ matocidal compositions.

Description: A new nenuatocidal composition, processes for productioll and its use rFhis invention relates to a new nematocidal composition, to processes for its production and to its use. The need to use chemical preparations for controlling nejrnatodes (nematocides) has increased over recent years. With numerous cultivated plants, particularly in warmer climates, it would not be possible today to obtain sufficient yields without controlling nematodes. The main group of phytopathogenic nematodes is the group of root parasites. Since they can only be controllea tnrough the roots or through the soil, large quantit.ies of nematocides are required in every case and, because they oly reach the affected parts of the plants in inadequate quantities, can result in serious pollution of the environment. It has now surprisingly been found that the qaatltlty of nematocides per hectare of cultivated area required for controlling nematodes can be reduced by up to 40-60% and, in some cases, by up to 80% providing the nematocide or nematocide mixture is used together with a phospholipide from the group comprising phosphatidyl choline, hydrogenated phosphatidyl cholines, phosphatidyl ethanolamine, N-ciyl pnosphatidyl ethanolamines, nosphatidyl inositol, phosphatidyl serine, lysolecithin and phosphatidyl glycerol in a ratio by weight of from i:0.2 to 1: :20 in addition to standard vehicles, diluents, solvents, propellents and/or other inert auxiliarles. In addition to greater economy of the treatment, the uptake of the nematocides by the plants troug the roots is considerbly increased by the addition of the phospholipides, so that a favourable long-iastiny effect is obtain. The better uptake of the n¯matocides by the plants prevents contamination of the soil by the neatocids. Finally, the phospholipides are generally natural and, in every case, non-toxic products which, by virtue of their nature and properties, do not themselves cause pollution of the environment. To produce the new nematocidal compositions, the nematocides are mixed with one or more phospholipides in a ratio by weight of from 1:0.2 to 1:20, preferably in a ratio by weight of from 1:0.5 to 1:10 and1 more particularly, in a ratio by weight of from 1:1 to 1:5. Suitable phospholipides are the commercially available phosphatidyl cholines or phosphatidyl choline mixtures such as, for example, ehospholiponR25 (25% of phosphatidyl choline, 25% of phosphatidyl ethanolamine and 20% of phosphatidyl inositol) PhospholiponR55 (55% of phosphatidyl choline, 25% of phosphatidyl ethanolamine and 2% of phosphatidyl inositol! Phospholipon"80 (80% of phosphatidyl choline and 10% of phosphatidyl ethanolamine) PhospholiponR100 (96% of phosphatldyl choline) PhospholiponR100H (96% of hydrogenated phosphatidyl choline) PhospholiponR38 (38% of phosphatidyl choline, 16% of N-acetyl phosphatidyl ethanol amine and 4% of phosphatidyl ethanolamine). It is particularly preferred to use natural phosphatidyl cholines which may be obtained by the processes described in the-following patents: DE-PS No. 1,047,597, DE-PS No. 1, 053,299, DE-PS No 1,617,679, DE-PS No. 1,617,680, German Patent Applications DE-OS No. 30 47 048, DE-OS No. 30 47 012 or DE-OS No. 30 47 0I1. ì Suitable N-acyl phosphatidyl ethanolamines are in particular those in which the acyl group emanates from saturated or olefinically unsaturated fatty acids containing I from 2 to 20 carbon atoms, particularly from saturated fatty acids containing from 2 to 5 carbon atoms or saturated or mono-olefinically unsaturated fatty acids containing 14, 16, 18 or 20 carbon atoms. The nematocide used may be virtually any nematocide such as, for example, 0-.(2,4-dichlorophenyl)-O,O-diethyl thiophosphate.(dichlofen- thion) thiophosphoric acid-O,O-diethyl-0-2-pyrazinyl ester (zinophos) o; O-diethyl-O- ( 4-methyl-sulfinyl-phenyl )-thionophosphoric- acid ester (fensulfothion) 2-methyl-2-(methylthio)-propionaldehyde-o-(methylcarbonyl)- oxime (aldicarb) 3,5-dimethyl-1,3,5-2H-tetrahydrothiadiazine-2-thioneidazOmec) dichlorpropen (a mixture of dichloropropane and dichloro propene). The individual nematocidcs may be used either on thei own or in combination with other nematocides or, if desired, eten with herbicides or acaricides following the addition of the phospholipides. The new nematocide/phospholipide compositions may be used for example for controlling the following nematodes: free-living root nematodes such as, for example, Pratylenchus-, Rotylenchus-, Tylenchorhynchus-, Trichodorus-, Longidorus-, Xiphinema species, above all on roots of cereal crops, beet crops, potatoes, vegetables, carrots, orchards, banana plantations-, coffee or tea plantations; root bale nematodes such as, for example, Meloidogyne species, above all in tobacco, cotton, vegetables and ornamental plants; mystic nematodes, for example Heterodera species, in potato, oats, hops, clover, vegetables etc.; stem nernatodes, particularly Ditylenchus species, in rye, tobacco, beet crops, onions, corn, oats, clover, ornamental plants; and leaf nematodes, particularly Aphelenchoides species, mainly in rice, cocoa, strawberries and ornamental plants. The new nematocidal compositions may be prepared in the following manner: The phospholipide or phospholipides is/are dissolved in organic solvents, such as for example toluene, xylene, ethyl acetate, ethanol or methanol or mixtures of. these solvents. The choice of the solvent or solvent mixture will depend upon the solubility of the nematocide used. The nematocide or the commercial product containing the nematocide is dissolved in the phospholipide solution, optionally by heating. On completion of dissolution, the solvent is removed by heating in vacuo. The product thus obtained is converted into a suitable, standard commercial form by the addition of any suitable auxiliaries still necessary, such as for example fillers, vehicles, diluents, wetting agents, stabilisers, gelating agents and extenders. The new nematocidal compositions may also be prepared by mixing the nematocides or the commercial product containing the nematocides with the phospholipide(s) and any auxiliaries and fillers which may still be necessary, dissolving or suspending the resulting mixture in an organic solvent and subsequently removing the solvent. A mixture ready for use is obtained in this way. In the case of nematocides which are soluble in water or in water/alcohol mixtures, the nematocide is with advantage first dissolved in water or water/alcohol mixtures and the phospholipide or phospolipide mixtures are converted into a solution or emulsion by stirring or by the application of ultrasonic waves. The emulsifiers normally required may be added before or after this stirring operation. The emulsion or solution thus obtained is freed from the solvent mixture or water in the usual way, for example by distillation, spray-drying or freezedrying. The resulting product may then be used either as such or, if desired, in conjunction with suitable auxiliaries. The product may even be re-emulsified or re-dissolved in water and used as a spray preparation. Suitable vehicles are, for example, talcum, kaolin, bentonite, kieselguhr, lime or crushed rock. Examples of further auxiliaries are surface-active compounds, such as soaps (fatty acid salts), fatty alcohol sulfonates or alkyl sulfonates. Gelatin, casein, albumin, starch or methyl cellulose may be used as stabilisers or protective colloids. The new nematocidal compositions may be used in liquid or solid form, for example in the form of dusting powders, granulates, sprays, aerosols, emulsions or solutions. EXAMPLE 1 Production of 1 kg of a dusting powder effective against migrating root nematodes in ornamental plants and containing aldicarb as its active ingredient: 50 g of aldicarb, 120 g of Phospholipon 25 and 0.1 g OI ascorbic palmitate are dissolved at 30 to 350C in 500 m. of toluene. The resulting solution is kneaded with 804 g of CaCO3 (quality: precipitated calcium carbonate) and the resulting paste is dried and ground. The powder is 1) dissolved with 15.0 g of lignin sulfonate in water and 2) mixed with 100 ml of a 10% gelatin solution. The pellets obtained are dried to form a powder in a fluidisedbed dryer. The product thus obtained is equivalent in its nematocidal activity to the commercial product containing 108 of aldicarb. EXAMPLE 2 Production of 1 kg of an emulsion spray effective against leaf and stem eelworms in ornamental plants and containing zinophos as its active ingredient: 240 g of zinophos, 240 g of Phospholipon 80 dissolved in 50 ml of ethanol, 5 g of Tagat 0 and 5 g of Tegomuls 0 are made up to 1 litre with Shellsol and dissolved. This mixture is used in the form of a 0.1% emulsion in water. It is equivalent in its effect to the same quantity of a 48% zinophos solution. EXAMPLE 3 Production-of a granular dusting preparation containing fensulfothion as its active ingredient: 50 g of fensulfothion and 100 g of Phospolipon 55 dissolved in 50 ml of ethanol are dissolved in 300 ml of Shellsol-A and the resulting solution sprayed homogeneously onto 825 g of CaCO3 (precipitated). The product is dried and ground. The powder is 1) dissolved with 15 g of lignin sulfonate in water and 2) stirred with 100 ml of a 10% gelatin solution and the pellets formed are dried in a fluidised-bed granulator. EXAMPLE 4 Production of 1 kg of an emulsion concentrate containing dichlofenthion as its active ingredient: 200 g of dichlofenthion, 200 g of phospholipon 80 in 50 ml of ethanol, 10 g of Marlowet iHF and 10 g of Cellosolve are made up to 1 litre with shellsol A. The resulting 20E solution of dichlofenthion is equivalent in its effect to 0.5 litre of an 80% commercial product. In the following Application Examples, the commercial products containing the-active ingredient referred to by its generic name were used as the active substance. EXAMPLE 5 Comparison test with dichlorpropen: To control potato nematodes, an infested field was sprayed with various mixtures and the percentage of potato plants still affected after the treatment was determined. Test Mixture Nematode infestation number in % 1 dichlorpropen 45 ml/m2 10 2 dichlorpropen 22.5 ml/m2 80 3 dichlorproen 22.5 slim2 10 +phosphatidyl choline 90 mg/l Test Mixture Nematode infestation number in % 4 dichlorpropen 11.75 mg/l 80 + phosphatidyl choline 90 mg/1 EXAMPLE 6 Comparison test with dazomet: For controlling seedling and wilting diseases and also germinating weed seeds and nematodes, compost soils are mixed with Basamid granulate and the percentage of germinating weed seeds and the infestation of sown common cabbage with Phoma lingam.and nematodes are determined. Test Mixture % % % number Weed Phoma lingam Nematon infestation infestation inf@@@ation 1 dazomet 40 g/mz 0 0 1 2 dazomet 20 g",m2 40 20 80 3 dazomet 20 g/m2 0 0 10 + phosphatidyl 90 mg/l choline 4 dazomet 20 g/m2 0 5 20 +phosphatidyl 45 mg/l choline

Claims: CLAIMS 1. A nematocidal composition characterised in that it consists of a) one or more nematocidally-active substances and b) one or more phospholipides from the group comprising phosphatidyl choline, hydrogenated phosphatidyl cholines, phosphatidyl ethanolamine, N-acyl phosphatidyl ethanolanlineE phosphatidyl inositol, phosphatidyl serine, lysolecithin and phosphatidyl glycerol in a ratio by weight of a:b of-from 1:0.2 to 1:20 in addition to standard vehicles, diluents, solvents, propellents and/or other inert auxiliaries. 2. A nematocidal composition as claimed in Claim 1, characterised in that constituents a) and b) are present in a ratio by weight of from 1:0.5 to 1:10. 3. A nematocidal composition as claimed in Claim 1 or 2, characterised in that consituents a) and b) are present in a ratio by weight of from 1:1 to 1:5. 4. A nematocidal composition as claimed in one or more of Claims 1 to 3, characterised in that phosphatidyl choline is used as the phospholipide. 5. A nematocidal composition as claimed in one or more of Claims 1 to 4, characteried in that dichlofenthion, zinophos, fensulfothion, aldicarb, dazomet and/or dichlorpropen is/are used as the nematocide. 6. The use of the composition claimed in any or Claims 1 to 4, for controlling nematodes. 7. A process for producing the nematocidal. compositions claimed in one or more of Claims 1 to 5, characterised in that the phospholipide is dissolved in an organic solvent or solvent mixture and the nematocide is dissolved in the resulting solution, optionally by heating and/or -stirring, after which the solvent or solvent mixture is removed in vaco and the mixture obtained is converted into a standard formulation using standard fillers and auxiliaries. 8. A process for producing the nematocidal compositions claimed in one or more of Claims 1 to 5, characterised in that the nematocde(s) is dissolved or suspended in an organic solvent together with one or more phospholipides and optionally together with standard fillers and auxiliaries, after which the solvent is removed. 9. A process for producing the nematocidal compositions claimed in one or more of Claims 1 to 5, characterised in that one or more water-soluble or alcohol-soluble nematocides is/are dissolved with one or more phospholipides either in water or in water/alcohol mixtures by stirring and/or gentle heating and/or by the application of ultrasoni- waves, after which the solvent or solvent mixture is removed.

Inventors: ETSCHENBERG, EUGEN, DR., GHYCZY, MIKLO, DIPL.-CHEM., DR., OSTHOFF, HEINRICH, DR.
Applicants: A. NATTERMANN & CIE. GMBH
Application year: 1982
Main classification: A01N57
IPC codes: A01N57