NOVEL PHOSPHORO (DI OR TRI) THIOATE DERIVATIVES, PESTICIDAL COMPOSITIONS CONTAINING THEM AND THE USE OF THE NOVEL DERIVATIVES FOR COMBATING PESTS

Abstract: Novel compounds are provided which exhibit activity as pesticides for combating arthropods, nematodes and/or fungi. The novel compounds have the formula: wherein: R¹ is (C₁-C₄) alkyl optionally substituted with one (C₁-C₄) alkoxy group and/or one to four of the same or different bro­ mo, chloro or fluoro atoms; (C₃-C₆) alkenyl; (C₃-C₆) alkynyl; phenyl optionally substituted with from one to three of the same or different alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy, alkylthio, cyano, ni­ tro, amino, or mono- or di-(C₁-C₃)alkylamino groups or atoms; or phenyl(C₁-C₅) alkyl, preferably phenyl(C₁-C₃) alkyl, optional­ ly ring-substituted from one to three of the same or differ­ ent alkyl, haloalkyl (preferably containing one to three of the same or different halo atoms), halo, alkoxy, alkylthio, cyano, ni­ tro, amino, or mono- and di-(C₁-C₃)alkylamino groups or at­ oms; R² is (C₂-C₅) alkyl (or methyl when X and Y are both S) op­ tionally substituted with from one to three of the same or differ­ ent alkyl, halo, alkoxy, alkylthio, cyano, nitro, heterocyclic, ami­ no, or mono- or di-(C₁-C₃)alkylamino groups or atoms; (C₃-C₆) alkenyl; (C₃-C₆) alkynyl; (C₃-C₆) cycloaliphatic or heterocycloaliphatic; phenyl optionally substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms ha­ lo, alkoxy, alkylthio, cyano, nitro, amino and mono- or di-(C₁-­ C₃)alkylamino; phenyl (C₁-C₅) alkyl, preferably phenyl-(C₁-C₃)alkyl, op­ tionally ring-substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy alkylthio, cyano, nitro, amino and mono- or di-(C₁-C₃)alkylami­ no; R³ is hydrogen; methyl; trifluoromethyl; alkoxy(C₁-C₄)carbonyl; or alkoxy(C₁-C₄)thiocarbonyl; R⁴ is hydrogen; (C₁-C₇) alkyl optionally substituted with one to three of the same or different substituents selected from benzoyl alkoxy­ (C₁-C₄)carbonyl, halo, alkoxy, alkylthio, cyano, nitro, and phe­ noxy or phenylthio each of the last two groups being optionally substituted with one to three of the same or different substitu­ ents selected from alkyl, alkoxy, halo, cyano, nitro, alkylthio, amino and mono- or di-(C₁-C₃)alkylamino; (C₃-C₆)alkenyl optionally substituted with one to three of the same or different substituents selected from alkoxy (C₁-C₄)carbonyl, phenyl, bromo, chloro and fluoro; (C₃-C₆)alkynyl; phenyl optionally ring-substituted with from one to five of the same or different halo atoms and/or up to three of the same or different substituents selected from alkyl containing one to three of the same or different halo atoms, alkoxy, alkylthio, cya­ no, nitro, amino and mono- or di-(C₁-C₃)alkylamino; or phenyl(or naphthyl)(C₁-C₃)alkyl optionally ring-substituted with one to five of the same or different halo atoms and/or with up to three substituents selected from alkyl, haloalkyl contain­ ing one to three of the same or different halo atoms, alkoxy, al­ kylthio, cyano, nitro, benzyloxy, methylenedioxy, amino and mono- or di-(C₁-C₃)alkylamino groups, and X, Y and Z are the same or different and are O or S, X and Z not both being O except for the case when (1) Y is S, (2) R¹ is n-C₃H₇ or S-C₄H₉, (3) R² is S-C₄H₉, (4) R³ is H and (5) R⁴ is methyl.

Description: NOVEL PHOSPHOROAMIDO(DI)THIOATE DERIVATIVES, PESTICIDAL COMPOSITIONS CONTAINING THEM AND THE USE OF THE NOVEL DERIVATIVES FOR COMBATING PESTS This invention concerns novel phosphoroamido (di or tri)thioate derivatives which are useful as pesticides, notably arthropodicides (notably insecticides and acaricides) , nematicides, and fungicides. U.S. Patent 4,263,288, discloses acaricidal, insecticidal, and nematicidal phosphoroamido(di)thioates. The several Magee patents, U.S. Patent Nos. 3,716,600, 4,049,679, 4,110,443, 3,914,417, 3,845,172, 3,885,032, and 3,825,634, disclose insecticidal phosphoroamido(di)thioates and methods of killing insects therewith. Column 18, lines 1-8 of UOS. 3,716,600 discloses broadly that, in addition to foliar application of the insecticidal compounds, one or more of the compounds may be applied in other liquid or solid formulations to the insects, their environment or hosts for example, directly to plants or soil so as to effect control of insects coming into contact therewith. Japanese Patent Specification No. 77012251 discloses phosphoroamidothioate derivatives having insecticidal activity. U.S. Patent 3,399,213, discloses parasiticidal and fungicidal acylphosphoroamidate compounds. U.S. Patent 3,511,635, discloses herbicidal organophosphorous-nitrogen compounds U.S. Patent 3,760,043, discloses phos?horoamidothioate derivatives which are stated to possess fungicidal, acaricidal, insecticidal, and nematocidal properties. Although the prior art discloses phosphoro amido(di)thioate compounds stated to have pesticidal, including insecticidal, activity, there remains a need for pesticidal compounds having improved pesticidal efficacy, and diminished detrimental effects such as mammalian toxicity and environmental waste, especially against soil insects such as the corn rootworm. The prior art, including the several Magee patents described above which constitute the closest art known, do not provide any specific teaching illustrative of the insecticidal activity of the compounds therein disclosed when applied in the soil to protect against soil organisms. It is well known to those skilled in the art that organophosphates having a high order of contact insecticidal efficacy when applied to foliar portions of plants offer relatively little economic value as plant protectants when applied to, or introduced into, the soil environment of the plants Organophosphates tend to be susceptible to rapid degradative processes in the soil due to the combination of such factors as the hydrolytic action of soil moisture, unfavorable soil pH conditions, bothof the above being exacerbated by the presence of soil micro flora and fauna capable of rendering the insecticidal compound inactive. Application of a pesticide to the soil in ordinary agricultural practice does not necessarily or usually coincide with the presence of susceptible life stages of the target pest. For example, the hatching of insect eggs may be either delayed or it may occur over an interval of several days to several or many weeks. Insect ova are not generally affected by organophosphate pesticides. Thus, pesticidal compounds having satisfactory residual activity, especially in the soil (ie pesticidal compounds that retain their pesticidal efficacy under atmospheric conditions over an interval of several days to several or many weeks) are required in order to assure satisfactory protection of plants against soil insects. Further, it is highly desirable that such pesticidal compounds having activity persistent over an interval of several days to several or many weeks elicit control over a diverse selection of soil organisms that are agricultural pests. The present invention provides novel phosphoroamido(di or tri)thioate derivatives having in one or more respects unexpected biological activity having regard to previously known pesticides of related structure. The novel derivatives are particularly noteworthy as insecticides, acaricides and nematicides when applied by soil application or by foliar application techniques, especially against soil pests, notably the corn (maize) rootworm. These and other objects as will become apparent, are achieved by the present invention which provides compounds of Formula I below: EMI3.1 wherein: R1 is (C1-C4) alkyl optionally substituted with one (Cl-C4)alkoxy group and/or one to four of the same or different bromo, chloro or fluoro atoms; (C3-C6) alkenyl; (C3-C6) alkynyl; phenyl optionally substituted with from one to three of the same or different alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy, alkylthio, cyano, nitro, amino, or mono- or di-(C1-C3)alkylamino groups or atoms; or phenyl (C1-C5) alkyl preferably phenyl (Cl-C3)alkyl, optionally ring-substituted with from one to three of the same or different alkyl, haloalkyl (preferably containing one to three of the same or different haloatoms), halo, alkoxy, alkyl thio, cyano, nitro, amino, or mono- and di-(C1-C3)alkylamino groups or atoms R2 is (C2-C5)alkyl (or methyl when X and Y are both S) optionally substituted with from one to three of the same or different alkyl, halo, alkoxy, alkylthio, cyano, nitro heterocyclic, amino, or mono- or di-(C1-C3)- alkylamino groups or atoms; (C3-C6) alkenyl; 5C3-C6) alkynyl; (C3-C6) cycloaliphatic or heterocycloaliphatic; ; phenyl optionally substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy, alkylthio, cyano, nitro, amino and mono- or di-(C1-C3)alkylamino; phenyl (C1-C5) alkyl, preferably phenyl (C1-C3) - alkyl, optionally ring-substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy, alkylthio, cyano, nitro, amino and mono or di-(C1-C3)alkylamino. R3 is hydrogen; methyl; trifluoromethyl; alkoxy(C1-C4)carbonyl; or alkoxy (C1-C4) thiocarbonyl. R4 is hydrogen; (C1-C 7) alkyl optionally substituted with one to three of the same or different substituents selected from benzoyl alkoxy (Cl-C4)carbonyl, halo, alkoxy, alkylthio, cyano, nitro, and phenoxy or phenyl thio each of the last two groups being optionally substituted with one to three of the same or different substituents selected from alkyl, alkoxy, halo, cyano, nitro, alkylthio, amino and mono- or di (C1-C3)alkylamino; (C3-C6)alkenyl optionally substituted with one to three of the same or different substituents selected from alkoxy(C1-C4)- carbonyl, phenyl, bromo, chloro and fluoro; (C3-C6) alkynyl; ; phenyl optionally ring-substituted with from one to five of the same or different halo atoms and/or up to three of the same or different substituents selected from alkyl containing one to three of the same or different halo atoms, alkoxy, alkylthio, cyano, nitro, amino, and mono- or di (C1-C3)alkylamino; or phenyl(or naphthyl) (C1-C3)alkyl optionally ring-substituted with one to five of the same or different halo atoms and/or with up to three substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, alkoxy, alkylthio, cyano, nitro, benzyloxy, methylene dioxy, amino and mono- or di-(C1-C3)alkyl- amino groups; and X, Y and Z are the same or different and are 0 or S, X and Y not both being 0 except for the case when (1) Y is S, (2) R1 is n-C3H7 or S-C4Hgr (3) R2 is S-C4Hg, (4) R3 is H and (5) R4 is methyl. In the compounds of Formula I above and those subsequently described it is preferred that, unless otherwise specified, the various alkyl, haloalkyl, alkoxy and alkylthio substituents each contain from one to four carbon atoms In a preferred embodiment for soil application, this invention provides compounds of Formula (I) wherein: R1 is (C1-C4) alkyl optionally substituted with from one to three of the same or different bromo, chloro or fluoro atoms,and R3 is hydrogen; methyl; or trifluoromethyl. A more restricted class of compounds of Formula (I) are those wherein R1 is (1) (C1-C4)alkyl optionally substituted with fluorine or methoxy or (2) trifluoromethyl substituted phenyl, R2 is (C1-C5)alkyl (or methyl when X and Y are both S) optionally substituted with methoxy, C3- or C4-alkenyl or methyloxadiazolylmethyl, R is hydrogen, methyl or trifluoromethyl and R4 is (Cl-C4)alkyl optionally substituted with chloro, methylthio, cyano, methoxycarbonyl, ethoxycarbonyl, benzoyl or phenylthio, the last group being optionally substituted with chloro; benzyl optionally ring-substituted with (a) up to five of the same or different substituents selected from fluorine, bromine and chlorine and/or (b) one or two of the same or different substituents selected from methoxy, trifluoromethyl, cyano, methyl, nitro, benzyloxy and methylenedioxy; naphthylmethyl; C3- or C 4-alkenyl optionally substituted with bromo or phenyl; and C3-alkynyl. In a more preferred embodiment for soil application, this invention provides compounds of Formula (I) wherein: R1 is methyl, ethyl, 2,2,2-trifluoroethyl, phenyl or benzyl; R2 is unsubstituted straight or branched chain (C3-C5) alkyl, phenyl or benzyl; R3 is hydrogen, methyl, or. trifluoromethyl; and R4 is methyl, ethyl, n-propyl, propenyl or benzyl optionally ring-substituted with from one to three of the same or different (C1-C3)alkyl, fluoro, chloro, bromo, methoxy, trifluoromethyl, nitro, or cyano groups or atoms In a most preferred embodiment for soil application, the invention provides compounds of Formula (I) wherein: : R1 is methyl, ethyl, or 2,2,2-trifluoroethyl; R2 is n-propyl, 3-pentyl, or l-methylpropyl; R is hydrogen; R4 is methyl, ethyl or ring-substituted benzyl containing one or two of the same or different (C1-C3)alkyl, fluoro, chloro, bromo, methoxy, trifluoromethyl, nitro or cyano substituents; and Z is O. Compounds disclosed in U.S. Serial No. 276,780 are, inter alia, those of Formula I wherein: R1 is (Cl-C4)alkyl optionally substituted with up to three substituents selected from F, C1, and Br; (C3-C6) akenyl; (C3-C6) alkynyl; phenyl optionally substituted with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S, CH3, CN, NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl(C1-C5)alkyl optionally ring-substituted or phenyl with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S, CF3, CN, NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; R2 is (C2-C5) alkyl optionally substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; (C3-C6) alkenyl; (C3-C6) alkynyl; (C3-C6) cycloaliphatic or heterocycloaliphatic; ; phenyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN, NO2 SR6 wherein R5 and R6 and NR R wherein R and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl (Cl-C5)alkyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN, NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (Cl-C3)alkyl; R3 is hydrogen; methyl; trifluoromethyl; alkoxy(Cl-C4)carbonyl; or alkoxy (C1-C4) thiocarbonyl; R is hydrogen; straight chain (C1-C7) alkyl; straight or branched chain (C1-C7) alkyl substituted with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S, CF3, CN, NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3)alkyl; (C3-C6) alkenyl; (C3-C6) alkynyl; ; phenyl optionally substituted with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S, CF31 CN, NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl(Cl-C5)alkyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN, NO2 and NR5R6 wherein R5 and R6 are the same or different and are, H or (C1-C3)alkyl; and X, Y and Z are as defined in Formula I. Especially preferred compounds are those having the following formulae: (H5C2O)P(S)(S sec-C4H9) (N(C2H5) (CHO)); (H5C2O)P(S)(S sec-C4H9) (N(C2H5) (CHS)); (H5C2O)P(S)(S sec-C4H9) (N(CH3) (CHO)); (H5C2O)P(O) (S sec-C4H9) (N(C2H5) (CHS)); and (H5C2O)P(S)(S sec-C4H9) (N(CH2C6H4CF3-3)(CHO)). Especially preferred compounds for foliar application are those of Formula (I) wherein: R1 is methyl, ethyl, or 2,2,2-trifluoroethyl; R2 is n-propyl, 3-pentyl, or l-methylpropyl; R hydrogen; and R4 is unsubstituted or subsituted benzyl wherein the substituent can be from one to two (C1-C3) alkyl, fluoro, chloro, bromo, trifluoromethyl, nitro or cyano groups. Compounds illustrative of the invention include the following: N-methyl-N-hydrogenthiocarbonyl-O-ethyl-S-n-butyl phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-n-butyl phosphoroamidodithioate N-methyl N-hydrogencarbonyl O-ethyl S-n-butyl phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(2 methylpropyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(2 methylpropyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl O-ethyl S-(2-methyl propyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(1 pentyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(1 pentyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl O-ethyl S-(l-pentyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl O-ethyl S-(2 methylbutyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(2 methylbutyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(2-methyl butyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(1-methyl butyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyi 0-ethyl S-(l-methyl butyl) phosphoroamidodithioate N-methyl N-hyd rogencarbonyl 0-ethyl S-(l-methylbutyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(3-methyl butyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(3-methyl butyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-(3-methylbutyl) phosphoroamidcdithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(2,2-dimethylpropyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl Ethyl S-(2,2-dimethylpropyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl 5-(2,2-dimethylpropyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (2-me thoxy- ethyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (2-methoxy- ethyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-(2-methoxy - ethyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-(3-nitropropyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl O-ethyl S-(3-nitro propyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0 -ethyl S-(2-cyano- ethyl) phosphoroamidothioate N-methyl N-n.ydrogenthiocarbonyl 0-ethyl S-(2-cyano- ethyl) phosphoroamidodithioate <RTI ID=12.12> N-methyl N-hydrogencar tonyl 0-ethyl S-(2-cyanoethyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-(3-chloropropyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (3-chloro- propyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (3 -chl oro- propyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-(2-fluoroethyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(2-fluoro- ethyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (2-fluoro- ethyl) phosophoroamidodithioate N-methyl N-hydrogenthiocarbonyl Q -ethyl S-ethylthio methyl phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-ethylthio ethyl phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-ethyl thiomethyl phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S(l ,l-dimethylethyl) thiomethyl] phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-((1,1-dimethylethyl)- thiomethyl] phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-((1,1-dimethylethyl)- thiomethyl] phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S- (2-bromoallyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl0-ethyl S-(2-bromo allyl)phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(2-bromo allyl) phosphoroamidothioate N-methyl N-hydrogencarbonyl 0-ethyl S-(3-butnyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(3-butenyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (3-butenyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(2-butenyl) phospho roamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (2-butenyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-(2-butenyl) phosphoroamidodithioate N-methyl N- hyd rogencar bonyl 0-ethyl S-(5-hexenyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- 6 -hexenyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (5-hexenyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-propargyl phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl 5-propargyl phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl 5-propargyl phosphoroamidodithioate N-methyl N- hydrogenthiocarbonyl 0-ethyl S-phenyl phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-phenyl phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-phenyl phos phoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-trichloro phenyl phosphoroamidodithloate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-tri- chlorophenyl phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl Stri chiorophenyl phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(l-phenyl ethyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(l-phenyl ethyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S-(l-phenylethyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-ethyl S- (5-phenyl-l- pentyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-ethyl S- (5-phenyl-l- pentyl) phosphoroamidodithioate N-methyl N-methylcarbonyl 0-ethyl S-(l-methylprosyl) phosphoroamidodi thioate N-methyl N-butylcarbonyl 0-ethyl S-(l-methylpropyl) phosphoroamidcdithioate N-heptyl N-hydrogencarbonyl 0-ethyl S- (l-methylpropyl) phosphoroamidcdithioate N-heptyl N-hydrogenthiocarbonyl 0-ethyl S-(l-methyl propyl) phosphoroamidothioate N-heptyl N-nydrogenthiocarbanyl 0-ethyl S-(l-methyl propyl) phosphorododithioate N-(3-methoxypropyl) N-hydrogenthiocarbonyl 0-ethyl S-(l-methylpropyl) phosphoroamidothioate N- (3 -methoxypropyl) N-hydrogenthiocarbonyl O-ethyl S- (l-methpropyl) phosphoroamidodithioate N-(3-methoxylpropyl) N-hydrogencarbonyl 0-ethyl S (l-methylpropyl) phosphoroamidodithioate N-(3-chloropropyl) N-hydrogencarbonyl 0-ethyl S (l-methylpropyl) phosphoroamidodithioate N-(3-chloropropyl) N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phosphoroamidothioate N-(3-chloropropyl) N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phosphoroamidodithioate N-(2-fluoroethyl) N-hydrogenthiocarhonyl 0-ethyl S-(1-methylpropyl) phosphoroamidodithioate N-(2-fluoroethyl) N-hydrogencarbonyl 0-ethyl S (l-methylpropyl) phosphoroamidodithioate N-(2-butenyl) N-hydrogencarbonyl 0-ethyl S-(1-methyl- propyl) phosphoroamidod ithioate <RTI ID=16.2> N- (2-butenyl) N-hydrogenthiocarbonyl O-ethyl S-(l-methyl propyl) phosphoroamidothioate N-(2-butenyl) N-hydrogenthiocarbonyl 0-ethyl S-(l-methyl propyl) phosphoroamidodi thioate N- (5-hexenyl) N-hydrogencarbonyl 0-ethyl S-(l-methyl propyl) phosphoroamidodithioate N-(5-hexenyl) N-hydrogenthiocarbonyl 0-ethyl S-(l-methyl- propyl) phosphoroamidodithioate N- (5-hexenyl) N-hydrogenthiocarbonyl 0-ethyl S-(l-methyl propyl) phosphoroamidothiaote N-[(2-carboethoxy)-1-propenyl] N-hydrogenthiocarbonyl 0-ethyl S-(l methylpronyl) phosphoroamidothioate N-[(2-carboethoxy)-1-propenyl] N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phophoroamidodithioate N-[(2-carboethoxy)-1-propenyl] N-hydrogencarbonyl 0 ethyl <RTI ID=16.8> S-(l-methylpropyl) phosphoroamidodi thioate N- (3-hexyn-l-yi) N-hydrogencarbonyl 0-ethyl S-(1- methylpropyl) phosphoroamidodithioate N-(3-hexyn-1-yl) N-hydrogenthiocarbonyl 0-ethyl S-(1 methylpropyl) phosphoroamidodithioate N-(3-hexyn-1-yl) N-hydrogenthiocarbonyl 0-ethyl S-(1 methylpropyl) phosphoroamidothioate N-phenyl N-hydrogencarbonyl 0-ethyl S-(l-methylpropyl) phosphoroamidodithioate N-phenyl N-hydrogenthiocarbonyl 0-ethyl S-(l-methyl propyl) phosphoroamidothioate N-phenyl N-hydrogenthiocarbonyl 0-ethyl S- (1-methyl- propyl) phosphoroamidodithioate N-p-chlorobenzyl N-hydrogenthiocarbonyl 0-ethyl S-(1 methylpropyl) phosphoroamidothioate N-p-chlorobenzyl N-hydrogenthiocarbonyl 0-ethyl S-(1 methylpropyl) <RTI ID=17.1> phosphoroamidodithioate N-o-chlorobenzyl N-hydrogencarbonyl 0-ethyl S-(l-methyl propyl) phosphoroamidodithioate N-(S-phenyl-1-pentyl) N-hydrogencarbonyl 0-ethyl S-(1 methylpropyl) phosphoroamidodithioate N-(5-phenyl-1-pentyl) N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phophoroamidothioate N- (5-phenyl-l-pentyl) N-hydrogenthiocarbonyl 0-ethyl S-(l-methylpropyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl-c-propyl S-(l-methylpropyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-propyl S-(l-methyl- propyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl propyl S-(l-methyl- propyl) <RTI ID=17.10> phoschoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-n-butyl S-(l-methyl propyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-n-butyl S-(l-methyl- propyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-n-butyl S- (l-methylpropyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-(2,2,2-trifluoroethyl) S-(1-methylpropyl) phosphoroamidotihioate N-methyl N-hydrogenthiocarbonyl 0-(2,2,2-trifluoroethyl) S-(1-methylpropyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-(2,2,2-trifluoroethyl) S-(l-methylpropyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-allyl S- (l-methylpropyl) phosphoroamidod ithioate N-methyl N-hydrogenthiocarbonyl 0-allyl S-(l-methyl- propyl) phosphoroamidodithioate N-methyl N-hydrogenthiccarobnyl 0-allyl S-(l-methyl propyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-(3-butenyl) Sz (1-methyl propyl) phosphoroamidothioate N-methyl N-hydrogenthiocarobnyl 0-(3-butenyl) S-(l-methyl propyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0-(3-butenyl) S-(1-methyl propyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 3-propargyl S-(l-methyl propyl) phosphoro2midodithioate N-methyl N-hydrogenthiocarbonyl 0-propargyl S- (1- methylpropyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-propargyl S- (1- methylpropyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl <RTI ID=18.7> 0-(3-hexyn-1-yl) S-(1- methylpropyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-(3-hexyn-1-yl) S-(1-methylpropyl) phophoroamidodithioate N-methyl N-hydrogencarbonyl 0-phenyl S-(1-methyl- propyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0-phenyl S-(l-methyl propyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-pheny S-(l-methyl propyl) phosphoroamidodithioate N-methyl N-hydrogencarbonyl 0- (2-phenylethyl) S-(1- methylpropyl) phosphoroamidodithioate N-methyl N-hydrogenthiocarbonyl 0- (2-phenylethyl) S- (1- methyipropyl) phosphoroamidothioate N-methyl N-hydrogenthiocarbonyl 0-(2-phenylethyl S-(1 methylpropyl) phosphoroamidodithioate S,S'-dibutyl N-hydrogenthiocarbonyl N-methyl phosphoro amidodithioate N-hydrogencarbonyl N,S-dimethyl S'-(1-methylpropyl) phosphoroamidotrithioate N-methylthiocarbonyl N,S,S'-tripropyl phophoroamidodi thioate S-ethyl N-heptyl S'-propyl N-trifluoromethylcarbonyl phosphoroamidotrithioate S-methyl S -pentyl N-propyl N-propoxymethylthiocarbonyl phosphoroamidodithioate S-ethyl S'-(2-hexenyl) N-methyl N-trifluoromethylthiocar bonyl phosphoroamidotr i thioate N-ethyl S-methyl S -(2-propenyl) N-trifluoromethyl phosphoroamidotrithioate N-ethyl N-hydrogenthiocarbonyl S-methyl S -(l-methyl- propyl) phosphoroamidodithioate N-ethyl N-hydrogenthiocarbonyl S- (l-methylpropyl) S' (2-propynyl) phosphoroamidotrithioate N-ethyl S- (2 -hexynyl) N-hydrogencarbonyl S -(l-methyl- propyl) phosphoroamidotrithioate S-(2-fluorobutyl) N-hydrogenthiocarbonyl N-methyl S'-(1- methylethyl) phosphoroamidodithioate N-methylcarbonyl S-phenyl N,S'-dipropyl phosphoroamido trithioate S-benzyl S'-(1-ethylpropyl) N-hydrogenthiocarbonyl N-methyl phosphorotriamidothiate S-butyl N-ethyl N-methylcarbonyl S'- (5-phenylpentyl) phosphoroamidotrithioate S-butyl N-methylthiocarbonyl N-(2-propenyl) S'-propyl phosphoroamidodithioate N-(3-hexenyl) N-hydrogencarbonyl S,S'-dipropyl phos phoroamidotrithioate N-(3-hexyny) N-hydrogenthiocarbonyi S-methyl S -(1- methylpropyl) phosphoroamidodithioate S-ethyl N,S'-di-(3-propynyl) N-trifluoromethylthiocarbonyl phosphoroamidodithioate N-benzyl N-hydrogenthiocarbonyl <RTI ID=20.2> S,S'-dipropyl phosphoroamidotrithioate N- (carboethoxymethyl) -N-hydrogencarbonyl-O-ethyl-S- (l-methylpropyl) phosphoroamidodithioate N-(cyanomethyl)-N-hydrogencarbonyl-O-ethyl-S-(l methylpropyl) -phosphoramidodithioate N- (methylthiomethyl) -N-hydrogencarbonyl-O-ethyl-S- (1-methylpropyl)phosporoamidodithioate N-4-fluorobenzyl-N-hydrogencarbonyl-O-ethyl-S-el- methylpropyl)-phosphoroamidodithioate N-3-methoxybenzyl-N-hydrogencarbonyl-0-ethyl-S-(1methylpropyl)-phosphoroamidodithioate N- 3-trifluoromethylbenzyl-N-hydrogencarbonyl-O-ethyl- S-(1-methylpropyl)phosphoroamidodithioate N-4-chlorophenylthiomethyl-N-hydrogencarbonyl-O-ethyl- S-(1-methylpropyl)phosphoroamidodithioate N-3-phenyl-2-butenyl-N-hydrogencarbonyl-O-ethyl-S (1-methylpropyl)phophoroamidodithioate N-l-methylbenzyl-N-hydrogencarbonyl-O-ethyl-S-(lmethylpropyl)-phosphoroamidodithioate N-phenyl-N-hydrogencarbonyl-O-ethyl-S- (l-methylpropyl) - phosphoroamidodithioate N-4-chloropheno zymethyl-N-hydrogencarbonyl-O-ethyl-S- (l-methylpropyl) phosphoroamidodithioate N-l-naphthylmethyl-N-hydrogencarbonyl-O-ethyl-S-(lmethylpropyl)-phosphoroamidodithioate N-2-bromobenzyl-N-hydrogencarbonyl-O-ethyl-S-(lmethylpropyl)-phosphoroamidodithioate N-2-chloro-6-fluorobenzyl-N-hydrogencarbonyl-O-ethyl S-(1-methylpropyl)phosphoroamidodithioate N-4-methylthiobenzyl-N-hydrogencarbonyl-O-ethyl-S (l-methylpropyl)phosphoroamidodithioate The method of controlling pests, according to the invention comprises applying directly to the pests notably insects, nematodes and/or acarids or to the loci to be freed or protected from attack by the pests an amount of one or more compounds of Formula (I) which is sufficient to combat the pest(s) in question. In one preferred embodiment, the method of the invention comprises applying on or in the soil pesticidally effective amount of one or more compounds of Formula (I) wherein: R1 is methyl, ethyl, 2,2,2-trifluoroethyl, phenyl or benzyl; R2 is unsubstituted straight or branched chain (C3-C5) alkyl, phenyl or benzyl; R3 is hydrogen; R4 is methyl, ethyl, n-propyl, propenyl, or unsubstituted or substituted benzyl; and X, y and Z are, independently, 0 or S. The following compounds are illustrative of the more preferred group of compounds useful by soil application techniques: (H5C2O)P(S)(S-sec-C4Hg)(N(C2H5)(CHO)); (H5C2O)P(S) (S-sec-C4H9) (N(C2H5) (CHS)); (H5C2O)P(O) (S--C3H7) (N(CH3) (CHS)); (H5C2O)P(S) (S-n-C3H7) (N(CH3) (CHO)); (H5C20)P(S) (S-n-C3H7)(N(CH,) (CHS)); (H5C2O)P(O) (S-sec-C4H9) (N(CH3) (CHS)); (H5C2O)P(S) (S-sec-C4H9) (N(CH2CF3)(CHO)); (H5C2O)P (S) (S-sec-C4H9) (N(CH2CH=CH2) (CHO)); and ((H5C2O)P(O) (S-3-pentyl) (N(C2H5)(CHS)). Especially preferred in the method of the invention are the following compounds: (H5C2O)P(S)(S-sec-C4H9)(N(C2H5)(CHO); (H5C2O)P(S) (S-sec-C4H9) (N(C2H5) (CHS)); and (H5C2O)P (S) (S-sec-C4H9) (N(CH3) (CHO)). In another preferred embodiment the method of the invention comprises applying to crop plants by foliar application techniques a pesticidally effective amount of one or more of the following compounds, viz: (H5C2O)P(S) (S-sec-CqHg) (N(CH2C6H4CN -4) (CHO)) (H5C2O)P(S) (S-sec-C4H9) (N(CH2C6H4F-4) (CHO) andr particularly (H5C2O)P (S) (S-sec-C4H9 (N(CH2C6H4CN-4) (CHO)) and (H5C2O)P(S) (S-sec-C4H9) (N(CH2C6H4NO2-4) (CHO)) The compounds of Formula I can be obtained by methods described in the literature for the preparation of analogous compounds or by methods specially devised for the purpose. One method for the preparation of hydrogencarbonyl and hydrogenthiocarbonyl phosphoroamido (di)thioates involves conversion of S-alkyl phosphorodichlorothioates to the products in four or five steps as is illustrated by the following reaction scheme: EMI23.1 Another method for the preparation of hydrogencarbonyl and hydrogenthiocarbonyl phosphoroamido(di)- thioates involves the S -alkylation of suitably substituted salts according to the following reaction: EMI24.1 The product of this alkylation reaction having the formula (IV) can then be further treated as illustrated in the reaction scheme set forth above to obtain the new compounds of the invention having the formula (VIII) and (XI). Still another method for the preparation of hydrogencarhonyl and hydrogenthiocarbonyl phosphoroamido (di)thioates involves the reaction of diethyl chlorophosphite with a suitably substituted sulwenyl halide to obtain an intermediate 0,5-disubstituted phophorochloridothioate, corresponding to formula (III), designated below by the formula number (III'), in the reaction scheme set forth above, as follows: : EMI24.2 Intermediate (III') can be further reacted as set forth in the reaction scheme illustrated above to obtain the desired end products Yet another method for the preparation of hydrogencarbonyl and hydrogenthiocarbonyl phosphoroamido (di) - thioates involves the N-alkylation in the presence of a suitable base of a hydrogencarbonyl phosphoroamido(di)thioate according to the following reaction: EMI25.1 (XV) (X"=anion) (VI) The product of this reaction having the formula (VI) can be further reacted as set forth in the reaction scheme illustrated above to obtain the hydrogenthiocarbonyl phosphoroamido(di)thioate compound having the formula (VIII). The S,S-dialkyl phosphoroamidodithioates of the invention can be prepared according to the following sequence: EMI25.2 In using the compounds of the invention, they may be applied to the soil, absorbed by plants grown in the soil, and ultimately ingested by the pests (notably insects, nematodes and acarids) by means of ingestion of the plant parts. This mode of application is referred to as systemic application. Alternatively, the active compound may be applied to the soil and contacted therein with the insects and other pests to be controlled. This means of application is referred to as "soil" application. In another alternative the active compound may be foliarly applied to the plants to be freed from insects and other pests. When using the compounds defined above, the method of the invention is especially effective against soil insects when the active compound is applied on or in the soil in order to effect direct contact with the insects or other pests, including nematodes, acarids and fungi. For use as pesticides, the compounds of this invention are usually used in the form of formulations. For example, they can be formulated with an agronomically acceptable carrier or diluent, as solutions in organic solvents, suspensions, wettable powders, emulsifiable concentrates, dusts, granules or flowable emulsion concentrates. In such formulations, the compounds are usually present in a concentration of about 1 to about 95% by weight (eg 5%, 25%, 50 % or 75%) and are mixed with the agronomically acceptable liquid or solid carrier or diluent. When desired, suitable surfactants are likewise incorporated. Surfactants commonly used in the art can be found in the John W. McCutcheon, Inc. publication "Detergents and Emulsifiers Annual." By "agronomically acceptable carrier or diluent" is meant any substance which can be utilised to dissolve, disperse or diffuse the chemical incorporated therein without impairing the effectiveness of the pesticide and which does not create permanent damage to such environment as soil, equipment, and agronomic crops when utilized according to recommendations. The compounds of this invention can be taken up on or mixed with a finely particled solid carrier, as for example, clays, inorganic silicates, carbonates, and silicas Organic carriers can also be employed. Dust concentrates are commonly made wherein compounds are present in the range of about 20 to 80% by weight. For ultimate applications, these concentrates are normally extended with additional solid to give an active ingredient content of from 1 to about 20% by weight. Granular formulations can be made using granular or pelletized form of carrier, such as granular clays, vermiculite, charcoal or maize cobs and usually contain the active ingredient an amount from about 0.1 to about 25% by weight, eg 1 - 25% and more usually 5 - 15%. Granules which typically have an average diameter of about 0.5 to 2 mm, or comparable sieve sizes, can be made by mixing the active ingredient with a finely divided inert solid, if necessary, with the addition of a binder and then forming the mixture into granules in a granulating device. Alternatively, preformed granules of an inert solid can be coated or impregnated with the active pesticidal ingredient. Wettable powder formulations are made by incorporating the compounds of this invention in an inert, finely divided solid carrier along with a surfactant which can be one or more emulsifying, wetting, dispersing, or spreading agents or a blend of these. The compounds are usually present in the range of about 10 to about 80% by weight and surfactants in from about 0.5 to about 10% by weight. Commonly used emulsifying and wetting agents include polyoxyethylated derivatives of alkylphenols, fatty alcohols, fatty acids, alkylamines, alkylarene sulfonates and dialkyl sulfosuccinates. Spreading agents include such material as glycerol mannitan laurate and a condensate of polyglycerol and oleic acid modified with phthalic anhydride. Dispersing agents include such materials as the sodium salt of the copolymer of maleic anhydride and an olefin such as diisobutylene, sodium lignin sulfonate and sodium formaldehydenaphthalene sulfonates. One convenient method for preparing a solid formulation is to impregnate the compounds of this invention onto the solid carrier by means of a volatile solvent, such as acetone. In this manner, adjuvants, such as activators, adhesives, plant nutrients, synergists and various surfactants can also be incorporated. Eulsifiable concentrate formulations are prepared by dissolving the compounds of this invention in an agronomically acceptable organic solvent and adding a solvent-soluble emulsifying agent. Suitable solvents are usuallywater-immiscible and can be found in the hydrocarbon, chlorinated hydrocarbon, ketone, ester, alcohol and amide classes of organic solvents Mixtures of solvents are commonly employed The surfactants useful as emulsifying agents can constitute about 0.5 to about 10% by weight of emulsifiable concentrates and can be anionic, cationic or non-ionic in character. The concentration of the active ingredients can vary from about 10 to about 80% by weight, preferably in the range of about 25 to about 50* by weight. For use as pesticidal agents, these compounds should be applied in an effective amount sufficient to exert the desired pesticidal activity by techniques well known in the art. In certain situations, however, it may be desirable and advantageous to apply the compounds directly onto the loci to be protected or freed of pests without the benefit of any substantial amount of carrier. This is a particularly effective method when the physical nature of the toxicants is such as to permit what is known as "low-volume" application, that is, when the compounds are in liquid form or substantially soluble in higher boiling solvents. The application rate will, of course, vary depending upon the purpose of such application, the compound being utilized, the frequency of dissemination, and the like. Many of the above formulations can be utilized on animals for the control of parasites. For use as arthropodicides, e.g. acaricides and insecticides, dilute sprays can be applied at concentrations of active ingredient of from about 4.5 g to about 9 kg per 378.5 litres (about 0.01 to about 20 pounds of the active ingredients per 100 U.S. gallons) of spray. They are usually applied at concentrations of about 45 g to 2.25 kg per 378.5 litres (about 0.1 to about 5 pounds per 100 U.S. gallons). In more concentrated sprays, the active ingredient is increased by a factor of 2 to 40. With dilute sprays, applications are usually made to the plants until rln-off is achieved, whereas with more concentrated or low-volume sprays, the materials are applied as mists. For use as a nematocide or as a soil insecticide, the compounds can be applied as a dilute liquid preparation or as a solid formulation, preferably a granular formulation, by broadcasting, side-dressing, introduction into the seed furrow, soil incorporation, or seed treatment. The application rate can be from about 1 to about 50 pounds per acre of active ingredient and for economic reasons, preferably from about 1 to about 25 pounds per acre For use as a fungicide, the compounds can be applied by methods commonly employed, such as conventional high-gallonage hydraulic sprays, lowgallonage sprays, air-blast sprays, aerial sprays and dusts. The dilution and rate of application will depend upon the type of equipment employed, the method of application and diseases to be controlled, but the preferred effective amount is usually about 01/2 to about 56 kg/ha (0.1 to about 50 pounds per acre) of the active ingredient. As a fungicidal seed protectant, the amount of toxicant coated on the seed is usually at a dosage rate of about 2.8 to 566 g (about 0.1 to about 20 ounces per hundred pounds) of seed. As a soil fungicide the chemical can be incorporated in the soil or applied to the surface usually at a dose of about 0,112 to about 56 kg/ha (about 0.1 to about 50 pounds per acre) As a foliar fungicide, the toxicant is usually applied to growing plants at a dose of 0.28 to 11 kg/ha (about 0.25 to about 10 lbs per acre). The compounds of this invention can be utilized as the sole pesticidal agents or they can be employed in conjunction with other bactericides, fungicides, herbicides, insecticides, acaricides, and comparable pesticides. The following examples are presented to illustrate the preparation of representative compounds of this invention. These compounds are identified in Table I appearing later. All parts and percentages are by weight unless otherwise indicated. Example 1: N-ethyl N-hydrogencarbonyl O-ethyl S (l-methylpropyl) phosphoroamidodithioates A solution of N-ethyl O-ethyl S-(l-methylpropyl) phosphoroamidodithioate, 120.5g (0.50 mol), in 750 ml of dry tetrahydrofuran (THF) is cooled to -78 0C while being maintained under a nitrogen atmosphere. To this there is added a hexane solution, 229 ml, containing butyllithium (0.55 mol). The resulting reaction mixture is stirred for about 0.25 hr and to this there is then added all-at-once acetic-formic anhydride (0.55 mol). The resulting reaction mixture is then warmed to 0 C over a period of 2 hrs and filtered through a Celite (diatomoceous earth) filter pad. The solvent and excess aceticformic anhydride and acetic acid by-product are removed from the filtrate by distillation under reduced pressure to afford 118.6g (88% of theory) of product as a clear yellow oil. The compounds of Examples 2-5 are prepared by a procedure analogous to that of Example 1 except that acetic anhydride or trifluoroacetic anhydride are where appropriate substituted for acetic-formic anhydride: Example 2: N-ethyl N-methylcarbonyl O-ethyl S-(l methylpropyl) phosphoroamidodithioate Example 3: N-ethyl N-trifluoomethylcarbonyl O-ethyl S- (1-methylpropyl) phosphoroamidodithioate Example 4: N-ethyl N-hydrogencarbonyl O-ethyl S-(5 methyl-1 ,2, 4-oxadiazolymethyl) phosphoro amidodithi-oate Example 5: N-(2,2,2-trifluoroethyl N-hydrogen carbonyl 0-ethyl S-(1-methylpropyl) phosphoroamidodithioate. Example 6: N-methyl N-hydrogencarbonyl O-ethyl S (l-methylpropyl) phosphoroamidodithioate Formic acid, 4.48 a (0.105 mol) and acetic anhydride, 7.96 g (0.078 mol) are mized in a flask at room temperature and allowed to stand for 0.5 hr. After cooling this mixture in an ice bath, there is added N-methyl O-ethyl S-(l-methylpropyl) phosphoroamidodithioate, 12g (0.0527 mol). The resulting reaction mixture is warmed to room temperature and stirred for 1 day at room temperature. Removal of excess aceticformic anhydride and acetic acid by-product from the resulting reaction mixture by distillation under reduced pressure affords 13.4 g (100% of theory) of product as a colorless oil. Examples 7-14 and 48-64 are prepared by a procedure analogous to that of Example 6. Example 7: tI-methyl N-hydrogencarbonyl O-ethyl S ethyl phosphoroamidodithioate Example 8: N-methyl N-hydrogencarbonyl 0-methyl S (l-methylpropyl) phosphoroamidothioate Example 9: N-methyl N-hydrogencarbonyl O-m-trifluoro methylphenyl S-(1-methylpropyl) phosphoro amidodithioate Example 10: N-methyl N-hydrogencarbonyl O-ethyl 5-propyl- phosphoroamidodithioate Example 11: N-methyl N-hydrogencarbonyl O-ethyl S isopropyl phosphoroamidodithioate Example 12: N-methyl N-hydrogencarbonyl 0-ethyl S tert-butyl phosphoroamidodithioate Example 13: N-methyl N-hydrogencarbonyl O-ethyl S- (3-pentyl) phosphoroamidodithioate Example 14: N-methyl N-hydrogencarbonyl methyl S-allyl phosphoroamidodithioate Example 15: N-ethyl N-hydroenthiocarbonyl O-ethyl S- (l-methylpropyl) phosphoroamidodithioate A solution of N-ethyl N-hydrogencarbonyl O-ethyl S-(l-methylpropyl) phosphoroamidodithioate, 65 g (0.24 mol), and 2 ,4-bis-(4-methoxyphenyl) -2,4-dithioxo-l,3,2 ,4- dithiadiphosphetan, 60.7g (0.15 mol) in 750 ml of 1,2dimethoxyethane is stirred and heated at reflux temperature for about 2 hrs. The resulting clear yellow solution is cooled and the solvent is removed by distillation under reduced pressure. Hexane, 11, is added to the residue and the resulting mixture is first stirred vigorously for 0.25 hr and then allowed to stand for 0.25 hr. The hexane layer is decanted off and the hexane is removed from this portion by distillation under reduced pressure to afford 42 g (61% of theory) of product as a yellow oil. The product is further purified by eluting a hexane solution of the product on a chromatographic column using Bio-Sil A (a silica gel chromatography support product available from Biorad Laboratories U.S.A.). Example 16-25 and 65-93 are prepared by a procedure analogous to that of Example 15: Example 16: N-methylthiomethyl N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phosphoroamido dithioate Example 17: N-ethyl N-hydrogenthiocarbonyl 0-ethyl S-ethyl phosphoroamidodithioate Example 18: N-methyl N-hydrogenthiocarbonyl 0-ethyl S-n-propyl phosphoroamidodithioate Example 19: N-methyl N-hydrogenthiocarbonyl 0-ethyl S-isopropyl phosphoroamidodithioate Example 20: N-hydrogenthiocarbonyl 0-ethyl 5-(1 methylpropyl) phosphoroamidodithioate Example 21: N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phosphoroamidodithioate Example 22: N-allyl N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phosphoroamidodithioate Example 23: N-methvl N-hydrogenthiocarbonyl 0-ethvl S-tert-butyl phophoroamidodithioate Example 24: N-methvl N-hydrogenthiocarbonyl 0-ethvl S-(3-pentyl) phosphoroamidodithioate Example 25: N-methyl N-hydrogenthiocarbonyl 0-ethvl s-(1-methylpropyl) phosphoroamidothioate and 94-119 In Examples 26-35./a phosphoroamidothioate precursor is substituted for a phosphoroamidodithioate precursor as used in Example 1.5. Example 26 : N-oroovl N-hvdrccenthiocarbonvl O-ethvl S-(1-methylpropyl) phosphoroamidothioate Example 27: N-butvl N-hvdrocenthiocarbonvl 0-ethvl S-(1-methylpropyl) phosphoroamidothioate Example 28: N-benzyl N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phosphoroamidothioate Example 29: N-methylthiomethyl N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phosphoro amidothioate Example 30: N-methyl N-hydrogenthiocarbonyl 0-ethyl S-ethyl phosphoroamidothioate Example 31: N-methvl N-hydrogenthiocarbonyl O-ethvl S-n-propyl phosphoroamidothioate Example 32: N-methyl N-hydrogenthiocarbonyl 0-ethvl S-isopropyl phosphoroamidothioate Example 33: N-allyl N-hydrogenthiocarbonyl 0-ethyl S-(1-methylpropyl) phophoroamidothioate Example 34: N-methyl N-hydrogenthiocarbonyl 0-ethyl S-(3-pentyl) phosphoroamidothioate Example 35: N-ethyl N-hydrogenthiocarbonyl 0-ethyl S-(3-pentyl) phosphoroamidothioate Example 36: N-allyl N-hydrogencarbonyl 0-ethyl S-(1 methylpropyl) phosphoroamidodithioate To a solution of N-hydrogencarbonyl 0-ethyl S-(1- methylpropyl) phosphoroamidodithioate, 11.2g (G.46 mol), and ally bromide, 9.4g (0.056 mol) , in 100 ml of methyl ethyl ketone is added powered K2CO3, 8.32g (0.060 mol). The resulting suspension is stirred in ambient temperature for 24 hr. and then filtered. The solvent is remove ed from the filtrate by distillation under reduced pressure to afford 9.lg (87% of theory) of product as a pale yellow oil. Further purification is effected by high pressure liquid chromatography (HPLC) techniques. and 120-145 Examples 37-40/are prepared by a procedure analogous to that of Example 36: Example 37: N-propargyl N-hydrogencarbonyl O-ethyl S-(l-methylpropyl) phosphoroamidodithioate Example 38: N-methylthiomethyl N-hydrogencarbonyl O ethyl S-(l-methylpropyl) phosphoroamido dithioate Example 39: N-butyl N-hydrogencarbonyl O-ethyl S-(1 methylpropyl) phosphoroamidodithioate Example 40: N-hydrogencarbonyl O-ethyl S-(l-methyl propyl) phosphoroamidodithioate Example 46: N-Hydrogencarbonyl N-methyl S-(l-methyl propyl) S'-propyl phosphoroamidodithioate Step 1) Preparation of N-methyl S-(l-methylpropyl) S'-propyl phosphoroamidothioate A solution of n-propyl mercaptan (23.63 g, 0,311 mol) and triethylamine (31.41 g, 0,311 mol) in 100 ml of tetrahydrofuran is added dropwise to an ice-cooled solution of S-(l-methylpropyl) phosphorodichloridothioate (64.4g, 0,311 moles) in 200 ml of THF. The reaction is stirred for 1 hr. at room temp. , then methylamine (19.3g is ffi is bubbled into the reaction mixture. The reaction mixture is diluted with ether, filtered through Celite to remove the triethylamine hydrochloride and methylamine hydrochloride, and evaporated to give 75g of product as an oil which was purified by preparative high pressure liquid chromatography (HPLC), using two PrePak 500 silica gel columns in series. Step 2) Preparation of N-methyl S-(methylpropyl) S'-propyl phosphoroamidodithioate Formic acid, 97e, (1.04 g, 0.026 mol) is added to acetic anhydride (2.10g, 0.0206 mol) and stirred for 15 minutes at room temperature. The resulting formicacetic anhydride is added to N-methyl S-(1-methyl- propyl) S'-propyl phosphoroamidodithioate (2.5g, 0.0103 mol) and three drops of 85% phosphoric acid. The reaction is stirred for 24 hours at room temperature and evaporated under high vacuum to remove acetic acid and formic-acetic anhydride, leaving 2.lg of material. Purification was effected by preparative HPLC gave 0.5g of product as an oil. Examples 41-45 and 47 are prepared by appropriate modifications of the foregoing working examples. From the foregoing Examples, it may be seen that a noteworthy class of compounds of Formula (I) are those wherein R1 is (1) (C1-C4)alkyl optionally substituted with the same or different substituents selected from one to three or four of the same or different halo atoms and/or a (Cl-C4)alkoxy group or (2) phenyl substituted with from one to three of the same or different halo(C1-C4)alkyl groups containing one to three of the same or different halo atoms, Rê is (Cl-C5)alkyl (or methyl when X and Y are both S) optionally substituted with up to 3 of the same or different (C1-C4)alkoxy groups, (C3-C6)alkenyl or methyl oxadiazolylmethyl, R3 is hydrogen, methyl or CF3 and 4- R is (Cl-C4)alkyl optionally substituted with from one to three of the same or different substituents selected from halo, (C1-C4) alkylthio, cyano, alkoxy (C1-C4) carbonyl, benzoyl, phenylthio optionally substituted with from one to three of the same or different halo atoms; benzyl optionally ring-substituted with (a) up to five of the same or different fluorine, bromine or chlorine atoms and/or (b) one or two of the same or different substituents selected from (Cl-C4)alkoxy, halo(C1-C4)alkyl containing one or more of the same or different fluoro, chloro or bromo atoms, cyano, (Cl-C4)alkyl, nitro, benzyloxy and methylenedioxy; naphthyl (Cl-C4)alkyl, (C3-C6) alkenyl optionally substituted with from one to three of the same or different substituents selected from bromo, chloro, fluoro and phenyl; and (C3-C6)alkynyl. TABLE I EMI40.1 EMI40.2 Example <SEP> X <SEP> Y <SEP> Z <SEP> RÚ <SEP> Rê <SEP> R <SEP> R4 <tb> <SEP> 1 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <tb> <SEP> 2 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> CH3 <SEP> C2H5 <tb> <SEP> 3 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> CF3 <SEP> C2H5 <tb> <SEP> CH3 <tb> <SEP> # <tb> <SEP> 4 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> O# <SEP> H <SEP> C2H5 <tb> <SEP> 1 <SEP> 5 <tb> <SEP> N <SEP> 3 <SEP> N <tb> <SEP> # <tb> <SEP> CH2 <tb> <SEP> 5 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2CF3 <tb> <SEP> 6 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH3 <tb> <SEP> 7 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> C2H5 <SEP> H <SEP> CH3 <tb> <SEP> 8 <SEP> S <SEP> O <SEP> O <SEP> CH3 <SEP> s-C4H9 <SEP> H <SEP> CH3 <tb> <SEP> 9 <SEP> S <SEP> O <SEP> O <SEP> m-CF3-C6H4 <SEP> s-C4H9 <SEP> H <SEP> CH3 <tb> <SEP> 10 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> n-C3H7 <SEP> H <SEP> CH3 <tb> <SEP> 11 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> i-C3H7 <SEP> H <SEP> CH3 <tb> TABLE I Example X Y Z RÚ Rê R R4 12 S O O C2H5 t-C4H9 H CH3 13 S O O C2H5 CH(C2H5)2 H CH3 14 S O O C2H5 CH2CH=CH2 H CH3 15 S S O C2H5 s-C4H9 H C2H5 16 S S O C2H5 s-C4H9 H CH2SCH3 17 S S O C2H5 CH3 H C2H5 18 S S O C2H5 n-C3H7 H CH3 19 S S O C2H5 i-C3H7 H CH3 20 S S O C2H5 s-C4H9 H H 21 S S O C2H5 s-C4H9 H CH3 22 S S O C2H5 s-C4H9 H CH2CH=CH2 23 S S O C2H5 t-C4H9 H CH3 24 O S O C2H5 CH(C2H5)2 H CH3 25 O S O C2H5 s-C4H9 H CH3 26 O S O C2H5 s-C4H9 H n-C3H7 27 O S O C2H5 s-C4H9 H n-C4H9 28 O S O C2H5 s-C4H9 H CH2C6H5 29 O S O C2H5 s-C4H9 H CH2SCH3 30 O S O C2H5 C2H5 H CH3 31 O S O C2H5 n-C3H7 H CH3 32 O S O C2H5 i-C3H7 H CH3 33 O S O C2H5 s-C4H9 H CH2CH=CH2 TABLE I (cont.) Example X Y Z RÚ Rê R R4 34 O S O C2H5 CH(C2H5)2 H CH 35 O S O C2H5 CH(C2H5)2 H C2H5 36 S O O C2H5 s-C4H9 H CH2CH=CH2 37 S O O C2H5 s-C4H9 H CH2CH=CH 38 S O O C2H5 s-C4H9 H CH2SCH3 39 S O O C2H5 s-C4H9 H n-C4H9 40 S O O C2H5 s-C4H9 H H 41 S O O C2H5 s-C4H9 H CH2CN 42 O O S n-C3H7 s-C4H9 H CH3 42 O O S s-C4H9 s-C4H9 H CH3 44 S O O C2H5 s-C4H9 H H 45 S O O C2H5 s-C4H9 H CH2CN 46 O S O n-C3H7 s-C4H9 H CH3 47 O S O n-C4H9 s-C4H9 H CH3 48 S O O C2H5 i-C4H9 H CH3 49 S O O C2H5 n-C4H9 H CH3 50 S O O C2H5 i-C5H11 H CH3 51 S O O C2H5 CH2CH(CH3)CH2CH3 H CH3 52 S O O C2H5 s-C5H11 H CH3 53 S O O C2H5 CH2CH2CH=CH2 H CH3 TABLE I (cont.) Example X Y Z RÚ Rê R R4 54 S O O C2H5 CH2CH2OCH3 H CH3 55 S O O CH2CF3 s-C4H9 H CH3 56 S O O C2H5 CH(C2H5)2 H CH3 57 S O O C2H5 n-C3H7 H C2H5 58 S O O C2H5 n-C3H7 H H 59 S O O n-C3H7 s-C4H9 H C2H5 60 S O O n-C3H7 s-C4H9 H CH3 61 S O O CH2CF3 s-C4H9 H C2H5 62 S O O CH2CH2F n-C4H9 H CH3 63 S O O CH2CH2OCH3 s-C4H9 H CH3 64 S O O CH2CF2CF2H s-C4H9 H CH3 65 S S O 3-CF3C6H4 s-C4H9 H CH3 66 S S O C2H5 s-C4H9 H CH2SCH3 67 S S O C2H5 i-C4H9 H CH3 68 S S O C2H5 n-C4H9 H CH3 69 S S O C2H5 i-C5H11 H CH3 70 S S O C2H5 n-C5H11 H CH3 71 S S O C2H5 CH2CH(CH3)CH2CH3 H CH3 72 S S O C2H5 s-C5H11 H CH3 TABLE I (cont.) Example X Y Z RÚ Rê R R4 73 S S O C2H5 CH2CH2CH=CH2 H CH3 74 S S O C2H5 CH2CH2OCH3 H CH3 75 S S O CH2CF3 s-C4H9 H CH3 76 S S O n-C3H7 s-C4H9 H C2H5 77 S S O n-C3H7 s-C4H9 H CH3 78 S S O C2H5 s-C4H9 H CH2CO2CH3 79 S S O C2H5 s-C4H9 H CH2C6H5 80 S S O C2H5 s-C4H9 H CH2C5H4F-4 81 S S O C2H5 s-C4H9 H CH2C6H4OCH3-3 82 S S O C2H5 s-C4H9 H CH2C6H4CF3-3 83 S S O C2H5 s-C4H9 H CH2CH2CH2Cl 84 S S O C2H5 s-C4H9 H CH2SC6H4Cl-4 85 S S O C2H5 s-C4H9 H CH2C(Br)=CH2 86 S S O C2H5 s-C4H9 H CH2CH=CHC6H5 87 S S O C2H5 s-C4H9 H CH2CO2C2H5 88 S S O C2H5 CH2CH2OCH3 H CH3 89 S S O CH2CF2CF2H s-C4H9 H CH3 90 S S O CH2CF3 s-C4H9 H C2H5 91 S S O C2H5 s-C4H9 H CH2SC6H5 92 S S O C2H5 s-C4H9 H CH2CH=CHCH3 TABLE I (cont.) Example X Y Z RÚ Rê R R4 93 S S O C2H5 s-C4H9 H CH2C6H4NO2-4 94 O S O C2H5 s-C4H9 H CH2C#CH 95 O S O CH2CF3 s-C4H9 H CH3 96 O S O C2H5 CH2CH=CH2 H CH3 97 O S O C2H5 s-C4H9 H CH3 98 O S O C2H5 n-C4H9 H CH3 99 O S O C2H5 CH2CH(CH3)CH2CH3 H CH3 100 O S O C2H5 s-C5H11 H CH3 101 O S O C2H5 s-C4H9 H C2H5 102 O S O n-C3H7 s-C4H9 H CH3 103 O S O C2H5 s-C4H9 H CH2C6H4F-4 104 O S O C2H5 s-C4H9 H CH2C6H4OCH3-3 105 O S O C2H5 s-C4H9 H CH2C6H4CF3-3 106 O S O CH2CH2F s-C4H9 H CH3 107 O S O C2H5 s-C4H9 H CH2CH=CHCH3 108 O S O C2H5 C3H7 H CH2CH=CH2 109 O S O C2H5 C3H7 H CH2C#CH 110 O S O C2H5 s-C4H9 H CH2C10H7 111 O S O C2H5 s-C4H9 H CH2C6H4Br-2 112 O S O C2H5 s-C4H9 H CH2C6H3CIF-2,6 TABLE I (cont.) Example X Y Z RÚ Rê R R4 113 O S O C2H5 n-C3H7 H n-C3H7 114 O S O C2H5 n-C3H7 H n-C4H9 115 O S O C2H5 n-C4H9 H CH2C6H3CH3NO2-3,4 116 O S O C2H5 s-C4H9 H CH2C6H5-2,3,4,5,6 117 O S O C2H5 s-C3H7 H CH2C6H3Cl2-2,6 118 O S O C2H5 n-C3H7 H CH2C6H5 119 O S O C2H5 n-C3H7 H CH2CO2CH3 120 S O O C2H5 s-C4H9 H CH2CO2CH3 121 S O O C2H5 s-C4H9 H CH2C6H5 122 S O O C2H5 s-C4H9 H CH2C6H4F-4 123 S O O C2H5 s-C4H9 H CH2C6H4OCH3-3 124 S O O C2H5 s-C4H9 H CH2C6H4CF3-3 125 S O O C2H5 s-C4H9 H CH2CH2CH2Cl 126 S O O C2H5 s-C4H9 H CH2SC6H4Cl-4 127 S O O C2H5 s-C4H9 H CH2C(Br)-CH2 128 S O O C2H5 s-C4H9 H CH2CH=CHC6H5 129 S O O C2H5 s-C4H9 H CH2CO2C2H5 130 S O O C2H5 n-C4H9 H CH2C6H4NO2-4 131 S O O C2H5 s-C4H9 H CH2C6H4CN-4 132 S O O C2H5 n-C4H9 H CH2C(O)C6H5 TABLE I (cont.) EMI47.1 Example <SEP> X <SEP> Y <SEP> Z <SEP> RÚ <SEP> Rê <SEP> R <SEP> R4 <tb> <SEP> 133 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2C6H4Br-2 <tb> <SEP> 134 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2OC6H4Cl-4 <tb> <SEP> 135 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2C10H7 <tb> <SEP> 136 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2CH=CHCH3 <tb> <SEP> 137 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2C6H3F-2,6 <tb> <SEP> 138 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2C6H5-2,3,4,5,6 <tb> <SEP> 139 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C3H7 <SEP> H <SEP> n-C4H9 <tb> <SEP> 140 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C3H7 <SEP> H <SEP> CH2C6H5 <tb> <SEP> 141 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C3H7 <SEP> H <SEP> CH2CO2C2H5 <tb> <SEP> 142 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C3H7 <SEP> H <SEP> CH2CH2CH2Cl <tb> <SEP> 143 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2C6H4OCH2C6H5 <tb> <SEP> O <tb> <SEP> 144 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2-### <tb> <SEP> O <tb> <SEP> 145 <SEP> S <SEP> O <SEP> O <SEP> C2H5 <SEP> s-C4H9 <SEP> H <SEP> CH2C(CH3)=CH2 <tb> Tables II and III which follow, respectively, set forth the analytical data and nuclear magnetic resonance (rmr) data of representative compounds selected from Table I. "NA" means not available. TABLE II: Elemental Analysis % Calcd. (Found) Example Emp. Formula C H N EMI48.1 <tb> <SEP> 1 <SEP> C9H20EO2PS2 <SEP> 40.10(39.21) <SEP> 7.50(7.54) <SEP> 5.20(4.66) <tb> <SEP> 2 <SEP> NA <tb> <SEP> 3 <SEP> C10H19F3NO2PS2 <SEP> 35.59(36.30) <SEP> 5.68(5.40) <SEP> 4.15(4.13) <tb> <SEP> 6 <SEP> C8H18NO2PS2 <SEP> 37.60(38.10) <SEP> 7.10(7.05) <SEP> 5.48(5.49) <tb> <SEP> 7 <SEP> C6H14NO2PS2 <SEP> 31.71(31.41) <SEP> 6.21(6.43) <SEP> 6.16(6.16) <tb> <SEP> 8 <SEP> C7H16NO2PS2 <SEP> 34.83(35.13) <SEP> 6.68(6.97) <SEP> 5.80(5.56) <tb> <SEP> 9 <SEP> NA <tb> <SEP> 10 <SEP> C7H16NO2PS2 <SEP> 34.83(34.39) <SEP> 6.68(6.34) <SEP> 5.80(6.12) <tb> <SEP> 11 <SEP> C7H16NO2PS2 <SEP> 34.84(34.97) <SEP> 6.68(6.80) <SEP> 5.80(5.65) <tb> <SEP> 12 <SEP> C8H18NO2PS2 <SEP> 37.62(36.81) <SEP> 7.70(7.02) <SEP> 5.48(6.19) <tb> <SEP> 13 <SEP> C9H20NO2PS2 <SEP> 40.13(41.04) <SEP> 7.48(7.64) <SEP> 5.20(5.09) <tb> <SEP> 14 <SEP> NA <tb> <SEP> 15 <SEP> C9H20KOPS3 <SEP> 37.87(39.58) <SEP> 7.06(7.38) <SEP> 4.91(4.99) <tb> <SEP> 16 <SEP> NA <tb> 17 <SEP> C9H20NOPS4 <SEP> 34.00(35.74) <SEP> 6.34(6.65) <SEP> 4.41(3.78) <tb> <SEP> 18 <SEP> NA <tb> <SEP> 19 <SEP> NA <tb> <SEP> 20 <SEP> C6H14NOPS3 <SEP> 29.61(30.48) <SEP> 5.80(5.76) <SEP> 5.76(5.88) <tb> <SEP> 21 <SEP> C7H16NOPS3 <SEP> 32.66(33.61) <SEP> 6.27(7.06) <SEP> 5.44(6.57) <tb> <SEP> 22 <SEP> C7H16NOPS3 <SEP> 32.66(32.48) <SEP> 6.27(6.09) <SEP> 5.44(5.28) <tb> TABLE II: Elemental Analysis Example Emp. Formula C H N 23 C7H16NOPS3 32.66(33.14 6.26(6.42) 5.44(5.65) 24 C8H18NOPS3 35.40(36.16) 6.68(6.93) 5.16(5.36) 25 C10H20NOPS3 40.37(40.46) 6.77(7.24) 4.70(5.12) 26 C8H18NOPS3 35.40(35.75) 6.68(6.85) 5.16(5.35) 27 C9H20NOPS3 37.87(38.73) 7.06(7.17) 4.91(5.26) 28 C8H18N02PS2 37.62(36.06) 7.10(7.09) 5.48(5.58) 29 C10H22NO2PS2 42.30(42.20) 7.82(7.91) 4.94(4.88) 30 C11H24NO2PS2 44.40(44.20) 8.13(8.16) 4.70(4.72) 31 C14H22NO2PS2 50.73(49.74) 6.69(6,73) 4.22(4.29) 32 C9H20NO2PS3 35.85(35.85) 6.68(6.53) 4.64(4.77) 33 C6H14NO2PS2 31.70(31.14) 6.21(6.95) 6.16(6.35) 34 C7H16NO2PS2 34.83(34.24) 6.68(6.71) 5.80(5.78) 35 C7H16NO2PS2 34.84(34.38) 6.68(6.68) 5.80(5.91) 36 C10H20NO2PS2 42.68(41.74) 7.16(7.22) 4.97(5.12) 37 <RTI ID=49.7> CgH20N02PS2 40.13(39.96) 7.48(7.65) 5.20(5.35) 38 C10H22NO2PS2 42.65(42.28) 8.29(7.94) 5.24(5.29) 39 C10H20N02PS2 42.68(42.71) 7.16(7.31) 4.97(5.15) 40 C10H18NO2PS3 42.99(42.41) 6.49(6.23) 5.01(5.34) 41 CgH20N02PS3 35.85(35.98) 6.68(6.55) 4.64(4.76) 42 NA 43 011H24N02PS2 44.41(44.07) 8.13(8.12) 4.70(4.79) 44 C7H16PS2 34.8(35.16) 5.70(6.83) 5.80(4.87) 45 C9H17N202PSZ 38.55(38.07) 6.11(6.16) 9.99(9.61) 46 47 4.8 C8H18N02PS2 37.62(37.64) 7.10(6.99) 5.48(5.36) 49 C8H18NO2PS2 37.62(37.53) 7.10(6.99) 5.48(5.56) 50 09H20N02PS2 40.12(39.88) 7.48(7.54) 5.20(5.28) 51 C9H20NO2PS2 40.12(40.32) 7.48(7.58) 5.20(5.42) 52 C8H16N02PS2 37.92(38.42) 6.36(6.55) 5.52(5.67) 53 C8H16No2ps2 37.92(38.42) 6.36(6.55) 5.52(5.67) 54 C7H16NO3PS2 32.67(31.96) 6.26(6.19) 5.44(4.99) TABLE II: Elemental Analysis Example Emp. Formula C H N 55 NA 56 NA 57 NA 58 NA 59 60 NA 61 NA 62 C8H17FN02PS2 35.15(35.67) 6.27(5.98) 5.12(4.69) 63 C9H20NO3PS2 37.88(37.73) 7.06(7.16) 4.91(4.73) 64 C9H16F4NO2PS2 31.67(32.18) 4.73(4.70) 4.10(3.29) 65 C13H17F3NOPS3 40.29(41.98) 4.42(5.24) 3.62(3.72) 66 C9H20NOPS4 34.40(35.74) 6.34(6.65) 4.41(3.55) 67 C8H18NOPS3 35.40(35.49) 6.68(6.54) 5.16(5.02) 68 C8H18NOPS3 35.40(35.96) 6.68(6.70) 5.16(5.21) 69 C9H20NOPS3 37.86(39.03) 7.06(7.48) 4.90(4.94) 70 C9H22NOPS3 37.86(38.84) 7.06(7.42) 4.90(5.13) 71 C9H20NOPS3 37.86(39.48) 7.06(7.42) 4.90(4.80) 72 C9H20NOPS3 37.86(39.26) 7.06(7.62) 4.9(4.95) 73 C8H16NOPS3 35.66(37.50) 5.98(6.57) 5.19(6.57) 74 C7H16NO1PS3 30.75(31.79) 5.90(6.20) 5.12(4.65) 75 NA 76 NA 77 NA 78 Cl0H20No3PS3 36.45(37.01) 6.11(6.31) 4.25(4.57) 79 C14H22NOPS3 48.38(50.57) 6.38(6.44) 4.03(3.82) 80 C14H21FNOFS3 46.0(45.73) 5.79(5.67) 3.83(3.70) 81 C15H24NO2PS3 47.71(47.97) 6.40(6.65) 3.71(3.69) 82 C15H21F3NOPS3 43.35(44.76) 5.09(5.12) 3.37(3.13) 83 C10H21C1NOPS3 35.96(36.60) 6.34(6.60) 4.19(3.74) 84 C14H21C1NOPS4 40.6(43.04) 5.10(5.20) 3.38(2.82) 85 C10H19BrNOPS3 31.91(32.67) 5.08(5.34) 3.72(3.33) 86 C16H24NOPS3 51.4(51.18) 6.47(6.60) 3.75(3.99) TABLE II: Elemental Analysis Example Emp. Formula C H N 87 C11H22No3PS3 38.46(38.85) 6.45(6.68) 4.07(4.22) 88 C11H24NO2PS3 40.09(38.79) 7.34(6.71) 4.25(4.11) 89 NA 90 NA 91 NA 92 NA 93 94 C10H18NO2PS2 42.99(40.58) 6.49(6.86) 5.01(4.81) 95 C8H15F3NO2PS2 31.06(31.69) 4.89(4.80) 4.52(4.60) 96 C7H14NO2PS2 35.13(35.10) 5.89(6.03) 5.85(5.97) 97 C8H18NO2PS2 37.62(37.80) 7.10(7.12) 5.48(5.72) 98 C9H20N02PS2 40.10(39.58) 7.48(7.55) 5.20(5.01) 99 C9H20NO2PS2 40.10(39.60) 7.48(7.67) 5.20(5.18) 100 C9H20N02PS2 40.10(38.83) 7.48(7.48) 5.20(4.87) 101 NA 102 NA 103 C14H21FNO2PS2 48.11(48.01) 6.05(6.10) 4.00(4.04) 104 C15H24N03PS2 49.84(49.59) 6.69(6.44) 3.87(4.23) 105 C15H21F3NO2PS2 45.10(45.18) 5.30(5.48) 3.50(3.44) 106 NA 107 C11H22NO2PS2 44.72(44.52) 7.50(7.65) 4.74(4.90) 108 C9H18NO2Ps2 40.4(37.86) 6.78(6.91) 5.23(6.13) 109 C9H16N02PS2 40.73(40.49) 6.07(6.32) 5.27(5.35) 110 C18H24NO2PS2 56.66(55.68) 6.34(6.49) 3.67(3.42) 111 C14H21BrNO2PS2 40.97(41.43) 5.15(5.12) 3.41(3.42) 112 C14H20C1FNO2PS2 43.80(44.35) 5.25(4.68) 3.64(2.33) 113 C9H20NO2PS2 40.12(40.45) 7.48(6.74)' 5.20(4.16) 114 C10H22NO2PS2 42.37(41.58) 7.82(7.66) 4.94(4.82) 115 C15H23N2O5PS2 48.11(47.80) 6.19(6.52) 7.48(7.33) 1-16 C14H17F5NO2PS2 39.90(40.14) 4.06(4.16) 3.32(3.60) 117 C14H20Cl2NO2PS2 42.00(41.93) 5.03(4.88) 3.49(2.77) 118 N'. TABLE II: Elemental Analysis Example EmD. Formula C H 'N 119 NA 120 C10H20NO4PS2 38.32(38.48) 6.43(6.60) 4.47(4.88) 121 C14H22N02PS2 50.73(52.49) 6.69(6.86) 4.22(3.95) 122 C14H21FNO2PS2 48.11(46.97) 6.00(6.02) 4.00(3.76) 123 C15H24N03PS2 49.84(49.17) 6.69(6.71) 3.87(3.72) 124 C15H21F3NO2PS2 45.10(45.60) 5.30(5.45) 3.50(3.72) 125 C10H21ClNO2PS2 37.78(36.90) 6.66(6.74) 4.40(4.65) 126 C14H21C1NO2PS2 42.25(42.01) 5.31(5.49) 3.52(3.80) 127 C10H19BrNO2PS2 33.30(33.93) 5.31(5.41) 22.18(20.64) 128 C16H24NO2PS2 53.75(53.71) 6.70(6.72) 3.91(3.96) 129 C11H22NO4PS2 40.35(40.31) 6.77(6.87) 4.27(4.67) 130 C14H21N2O4PS2 44.60(43.52) 5.62(5.74) 7.44(7.21) 131 C15H21N2O2PS2 50.50(50.59) 5.93(6.08) <RTI ID=52.8> 7.86(7.74) 132 C15H22N03PS2 50.10(47.67) 6.17(6.49) 3.89(4.11) 133 C14H21BrNO2PS2 40.97(40.86) 5.15(5.01) 3.41(2.98) 134 C14H21ClNO3PS2 44.02(43.64) 5.54(5.55) 3.66(3.60) 135 C18H24NO2PS2 56.60(55.96) 6.34(6.13) 3.67(3.47) 136 C11H22NO2PS2 44.72(44.25) 7.50(7.71) 4.74(4.62) 137 C14H20C1FNO2PS2 43.80(43.63) 5.25t5.29) 3.64(3.47) 138 C14H17F5NO2PS2 39.90(39.99) 4.06(4.13) 3.32(3.45) 139 C10H22NO2PS2 42.37(42.10) 7.82(7.58) 4.94(5.30) 140 C13H20N02PS2 49.18(49.13) 6.35(6.34) 4.41(4.79) 141 C10H20NO4PS2 38.30(38.21) 6.43(6.53) 4.46(4.76) 142 C9H19C1NO2PS2 35.57(35.34) 6.30(6.36) 4.61(4.81) 143 C21H28NO3PS2 57.64(55.83) 6.44(6.43) 3.20(3.49) 144 C15H21C1NO4PS2 43.95(43.74) 5.16(5.22) 3.41(3.48) 145 C11H22NO2PS2 44.72(44.55) 7.50(7.46) 4.74(4.62) TABLE III - Nuclear Magnetic Resonance Data (ppm , #) Example 1: 8.90(s, 1H, CCH); 4.30(m, 2H, OCH2CH3); 3.68 (m, 1H, SCH) 3.60 (m, 2H, NCH2); 1.64 (m, 2H, SCHCH2); 1.40 (m, 3H, SCH(CH3); 1.40 (t, 3H, OCH2CH3); 1.40(t, 3H, NCH2CH3); 1.20 (m, 3H, SCH(CH3)CH2-CH3) Example 2: 4.20(m, 2H, OCH); 3.80(m, 2H, NCH2); 3.40 (m, 1H, SCH), 2.20 (m, 3H, NCCCH3); 1.64 (m, 2H, SCHCH2); 1.40 (t, 3H, OCH2CH3); 1.40 (t, 3H, NCH2CH3); 1.40(m, 3H, S CH CH3); 1.00 (m, 3H, SCH(CH3)CH2-CH3) Example 3: 4.30(m, 2H, CCH); 3.80(m, 2H, NCH2); 3.40 (m, 1H, SCH); 1.64 (m, 2H, SCHCH2); 1.40 (t, 3H, OCH2CH3); 1.40 (t, 3H, NCH2CH3); 1.40 (3H, SCHCH3); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 4: 8.90(s, 1H, CCH); 4.38(m, 2H, OCH2); 4.30 (d, 2H, SCH2) 3.58 (m, 2H, NCH2); 2.58 (s, 3H, ring CH3); 1.38 (m, 6H, NCH2CH3 and OCH2-CH3) Example 5: 8.75(s, 1H, CCH); 4.40(m, 4H, OCH2 andNCH3); 3.58 (m, 1H, SCH) 1.84 (m, 2H, SCHCH2); 1.50 (m, 6H, CCH2CH3 and SCHCH3); 1.10(m 3H, SCH(CH3)CH2CH3) Example 6: 8.90(s, 1H, CCH); 4.30(m, 2H, OCH2); 3.48 (m, 1H, SCH); 308 (d, 3H, NCH3); 1.78 (m, 2H, SCHCH2); 1.38 (t, 6H, OCH2CH3 and SCHCH3); 1.08(m, 3H, SCH(CH3)CH2-CH3) Example 7: 8.92(s, 1H, CCH); 4.38(m, 2H, OCH2); 3.15 (m, 2H, SCH2) 3.08 (d, 3H, NCH3); 1.38 (dt, 6H, SCHCH3 and OCH2CH3 Example 8: 8.90(s, 1H, CCH); 3.80(d, 3H, OCH3); 3.40 (m, 1H, SCH) 3.00 (d, 3H, NCH3); 1.70 (m, 2H, SCHCH2); 1.40 (t, 6H, OCH2CH3 and SCHCH3); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 9: 8.85(s, 1H, CCH); 7.50(s, 4H, aromatic); 3.50 (m, 1H, SCH) 3.19 (d, 3H, NCH3); 1.70 (m, 2H, SCHCH2); 1.38 (d, 3H, SCHCH3); 0.98 (m, 3H, SCH(CH3)CH2CH3 Example 10: 8.90(s, 1H, CCH); 4.30(m, 2H, OCH2); 3.00 (d, 3H, NCH3); 2.80 (m, 2H, SCH2); 1.78 (m, 2H, SCH2CH2); 1.40 (t, 3H, OCH2CH3); 1.00 (t, 3H, SCH2CH2CH3) Example 11: 8.88(s, 1H, CCH); 4.25(m, 2H, OCH2); 3.50 (m, 1H, SCH) 3.02 (d, 3H, NCH3); 1.20 (m, 9H, OCH2CH3) and SCH(CH3)2 Example 12: 8.90(s, 1H, CCH); 4.20(m, 2H, OCH2); 2.98 (d, 3H, NCH3) 1.58 (d, 9H, SCH(CH3)3; 1.30 (t, 3H, OCH2CH3) TABLE III - Nuclear Magnetic Resonance Data contd. Example 13: 8.90(s, 1H, CCH); 4.30(m, 2H, OCH2); 3.42 (m, 1H, SCH) 1.78 (m, 4H, SCH(CH2CH32; 1.50 (t, 3H, OCH2CH3); 1.10(m, 6H, SCH (CH2CH3)2 Example 14: 8.95(s, 1H, CCH); 5.90(m, 1H, SCH2CH=CH2); 5.36 (m, 2H SCH2=CH2); 4.30 (m, 2H, OCH2); 3.60 (m, 2H, SCH2CH=CH2); 3.00(d,3H NCH3); 1.40(t, 3H, OCH2CH3) Example 15: 9.33(d, 1H, CHS); 4.24(m, 4H, OCH2 and NCH2); 3.40 (m, 1H, SCH); 1.80 (m, 2H, SCHCH2); 1.42 (m, 9H, OCH2CH3, SCHCH3 and NH2CH3); 1.18(m, 3H, SCHCH3)CH2CH3 Example 16: 9.35(d, 1H, CCH); 5.30(dd, 2H, NCH2SCH3); 4.38 (m, 2H, OCH2); 3.40 (m, 1H, SCH); 2.20 (s, 3H, SCH3); 1.75(m, 2H, SCHCH2); 1.40(m, 6H, OCH2CH3 and 1.10 (m, 3H, SCH(CH3)CH2CH3) Example 17: 9.35(d, 1H, CHS); 4.30(m, 4H, OCH2 and NCH2); 2.40(d, 3H, SCH3); 1.40 (m, 6H, OCH2CH3 and NCH2CH3 Example 18: 9.30(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.50 (d, 3H, NCH3) 3.00 (m, 2H, SCH2); 1.80 (m, 2H, SCHCH2); 1.50 (t, 3H, OCH2CH3); 1.04 (m, 3H, SCH2CH2CH3) Example 19: 9.30(d, 1H, CHS); 4.38(m, 2H, OCH2); 3.60 (m, 1H, SCH), 3.35 (d, 3H, NCH3); 1.42 (t, 9H, OCH2CH3 and SCH(CH3)2 Example 20: 9.35(bd, 1H, CHS); 4.22(m, 2H, OCH2); 3.38 (m, 1H, SCH), 1.70 (m, 2H, SCHCH2); 1.38 (m, 6H, OCH2CH3 and SCHCH3); 1.00(m, 3H, SCH(CH3)CH2CH3 Example 21: 9.30(d, 1H, CHS); 4.20(m, 2H, OCH2); 3.40 (d, 3H, OCH3); 3.38 (m, 1H, SCH); 1.80 (m, 2H, SCHCH2); 1.45 (m, 6H, CCH2CH3 and SCHCH3); 1.00(m, 3H, SCH(CH3)CH2CH3 Example 22: 9.35(d, 1H, CHS); 6.00(m, 1H, NCH2CH=CH2) 5.40 (m, 2H, NCH2CHCH2); 4.38 (m, 4H, NCH2 and OCH2); 3.38(m, 1H, SCH); 1.80(m, 2H, SCHCH2); 1.50(m, 6H, OCH2CH3 and SCHCH3); 1.05(m, 3H, SCH(CH3)CH2CH3) Example 23: 9.30(d, 1H, CHS); 4.36(m, 2H, OCH2); 3.42 (d, 3H, NCH3); 1.58 (d, 9H, SC(CH3)3; 1.42 (t, 3H, OCHCH3) TABLE III - Nuclear Magnetic Resonance Data contd. Example 24: 9.35(d, 1H, CHS); 4.36(m, 2H, OCH2); 3.38(d, 3H, NCH2) 3.28 (m, 1H, SCH); 1.78 (m, 4H, SCH(CH2CH3); 1.40 (t, 3H, OCH2CH3); 1.00(m, 6H, SCH(CH2CH3)2 Example 25: 9.30(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.40 (d, 3H, NCH3); 3.38 (m, 1H, SCH); 1.78 (m, 2H, SCHCH2); 1.50 (t, 6H, CCH2CH3) and SCHCH3); 1.05(m, 3H, SCH2(CH3)CH2CH3) Example 26: 9.35 (d, 1H, CHS); 4.35(m, 2H, OCH2); 3.90(m, 2H, NCH2) 3.38 (m, 1H, SCH); 1.78 (m, 4H, SCHCH2) and NCH2CH2); 1.40(m, 6h, OCH2CH3 and SCHCH3); 1.00(m, 6H, NCH2CH3 and SCH(CH3)CH2CH3 Example 27: Not Available Example 28: 9.30(d, 1H, CHS); 7.10(m, 5H, aromatic); 5.00(m, 2H, NCH2); 4.00 (m, 2H, OCH2); 3.38 (m, 1H, SCH); 1.78 (m, 2H, SCHCH2); 1.50(t, 6H, OCH2CH3 and SCHCH3); 1.00 (m, 3H, SCH(CH3)CH2-CH3) Example 29: 9.30(d, 1H, CHS); 5.10(d, 2H, NCH2); 4.38(m, 2H, OCH2) 3.40 (m, 1H, SCH); 2.50 (S, 3H, NCH2SCH3); 1.75 (m, 2H, SCHCH2); 100 (m, SCH(CH3)-H2CH3) Example 30: 9.35(d, 1H, CHS); 4.30(m, 2H, OCH2); 3.36(d, 3H, NCH3) 2.90 (m, 2H, SCH2); 1.38 (dt, 6H, OCH2CH3 and SCH2CH3) Example 31: 9.35(d, 1H, CHS); 4.35(m, 2H, OCH2); 3.35(d, 3H, NCH3) 3.00 (m, 2H, SCH2); 1.80 (m, 2H, SCH2CH2); 1.50 (t, 3H, OCH2CH3); 1.02(t, 3H, SCH2CH2CH3) Example 32: 9.30(d, 1H, CHS); 4.38(m, 2H, OCH2); 3.50(m, 1H, SCH) 3.36(d, 3H, NCH3); 1.50(t, 9H, OCH2CH3 and SCH(CH3)2) Example 33: 9.38(d, 1H, CHS); 6.10(m, 1H, NCH2CH=CH3); 5,48(m, 2H, NCH2CH=CH3); 4.78(m, 2H, SCH2); 4.40 (m, 2H, OCH2); 3.40(m,1H, SCH); 1.80(m, 2H, SCHCH2); 1.40 (m, 6H, OCH2CH3 and SCHCH3); 1.00(m, 3H, SCH(CH3)CH2CH3). Example 34: 9.40(d, 1H, CHS); 4.35(m, 2H, OCH2); 3.38(m, 1H, SCH); 3.30(d, 3H, NCH3); 1.75(m, 4H, SCH(CH2CH3); 1.50(t, 3H, OCH2CH3); 1.10(m, 6H, SCH(CH2CH3)2 Example 35: 9.30(d, 1H, CHS); 4.30(m, 4H, OCH2 and NCH2); 3,40(m, 1H, SCH); 1.80 (m, 4H, SCH(CH2CH3); 1.50(t, 3H, OCH2CH3); 1.08(m, OH, SCH(CH2CH3)2 Example 36: 8.90(S, 1H, CCH); 6.00(m, 1H, NCH2CH=CH2) 5.40(m, 2H NCH2CH=CH2); 4.38(m, 4H, OCH2,NCH2); 3.42(m, 1H, SCH) 1.78(m,2H SCHCH2); 1.50(m, 6H, OCH2CH3) and SCHCH3); 1.02(m, 3H, SCH(CH3)CH2 CH3) Example 37: 8.85(S, 1H, CCH); 4.30(dd, 2H, NCHlCH); 4.38 (m, 2H, OCH2); 3.40(m, 1H, SCH); 2.38 (t, 1H, NCH2CHCH); 1.80(m, 2H, SCHCH2) 1.50(m, 6H, OCH2CH3 and SCHCH3); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 38: 8.9(S, 1H, CCH); 4.80(d, 2H, NCH2); 3.30 (m, 2H, OCH2) 3.38 (m, 1H, SCH); 2.30(S, 3H, NCH2SCH3); 1.78(m, 2H, SCHCH2); 1.50 (m, 6H, OCH2CH3) and SCHCH3); 1.02(m, 3H, SCH(CH3)CH2CH3) Example 43: 8.90(s, 1H, CCH); 3.50(m, 3H, OCH2, SCH); 3.00 (m, 2H, NCH2); 1.78(m, 2H, SCHCH2); 1.50(m, 10H, OCH2CH3 and NCH2CH2 CH2CH3); 1.00(m, 6H, SCH(CH3)CH2CH3 and NCH2CH2CH3). Example 44: 8.70(d, 1H, CCH); 8.65(s,NHCHD); 4.20(m, 2H, OCH2) 3.38(m, 1H, SCH); 1.78(m, 2H, SCHCH2); 1.50(m, 6H, OCH2CH3 and SCHCH3) 1.02(m, 3H, SCH(CH3)CH2CH3) Example 45: 8.70(s, 1H, CCH); 4.68(d, 2H, NCH2CN); 4.48(m, 2H, OCH2) 3.42(m, 1H, SCH); 1.78(m, 2H, SCHCH2); 1.50(m, 6H, OCH2CH3 and SCHCH3) 1.02(m, 3H, SCH(CH3)CH2CH3). Example 48: 8.68(S, 1H, CCH); 4.30(m, 2H, OCH2); 3.10(d, 3H, NCH3) 2.80(m, 2H, SCH2); 1.98(m, 1H, SCH2CH); 1.48(t, 3H, OCH2CH3); 1.00 (d, 6H, SCH2CH(CH3)2). Example 49: 8.70(s, 1H, CCH); 4.40(m, 2H, OCH2); 3.10(m, 3H, NCH3); 3.00(m, 2H, SCH2); 1.55(m, 7H, OCH2CH3 and SCH2CH2CH2CH3); 1,00(m, 3H, SCH2CH2CH3). Example 50: 8.70(s, 1H, CCH); 4.38(m, 2H, OCH2); 3.10(d, 3H, NCH3); 3.05 (m, 2H, SCH2); 1.70(m, 6H, OCH2CH3 and SCH2CH2CH); 1.10(d, 6H, SCH2 CH2CH(CH3)2. Example 51: 8.80(s, 1H, CCH); 4.38(m, 2H, OCH2); 3.10(d, 3H, NCH3) 3.00(m, 2H, SCH2); 1.70(m, 6H, OCH2CH3 and SCH2CH(CH3)CH2CH2); 1.00(m, 6H, SCH2CH)CH3)CH2CH3). Example 52: 8.75(s, 1H, COH); 4.38(m, 2H, OCH2); 3.30(m, 1H, SCH); 3.10 (d, 3H, NCH3); 1.78(m, 2H, SCHCH2); 1.50(m, 8H, OCH2CH3 and SCH(CH3)CH2 CH2); 1.00(m, 3H, SCH(CH3)CH2CH2CH3). Example 53: 8.70(s, 1H, CCH); 590(m, 1H, SCH2CH2CH=CH2); 5.20(m, 2H SCH2CH2=CH2); 4.38 (m, 2H, OCH2); 3.20(d, 3H, NCH3); 3.10(m, 2H, SCH2CH2); 2.60(m,2H,SCH2); 1.50(t, 3H, OCH2CH3). Example 54: 8.75(s, 1H, CCH); 4.40(m, 2H, OCH2); 3.70(m, 2H, SCH2CH2CH2); 3.40 (s, 3H, SCH2CH2OCH3) 3.20(d, 3H, NCH3); 3.15(m, 2H, SCH2); 1.50(t, 3H, OCH2CH3). Example 55: 8.75(s, 1H, CCH); 4.40(m, 2H, OCH2); 3.60(m, 1H, SCH); 3.00 (d, 3H, NCH3); 1.78(m, 2H, SCHCH2); 1.50(m, 3H, SCH2CH3); 1.00(m,3H, SCH(CH3)CH2CH3). Example 56: 8.80(s, 1H, CCH); 4.40(m, 2H, OCH2); 3.70(m, 3H, NCH2 and SCH); 1.60(m, 7H, OCH2CH3 and SCH(CH2CH3)2; 1.00(m, 6H, SCH(CH2 CH3)2. Example 57: 8.75(s, 1H, CCH); 4.40(m, 2H, OCH2); 3.60(m, 2H, NCH2) 2.98(m, 2H, SCH2); 1.80(m, 2H, SCH2CH2); 1.40(m, 6H, NCH2CH3 and OCH2CH3); 1.00(m, 3H, SCH2CH2CH3) Example 58: 8.75(d, 1H, COH); 8.70(s,1H, NHCHD); 4.40(m, 2H, OCH2) 3.00(m, 2H, SCH2); 1.80(m, 2H, SCH2CH2); 1.50(m, 3H, OCH2CH3); 1.10 (m, 3H, SCH2CH2CH3) Example 59: 8.70(s, 1H, CCH); 4.20(m, 2H, OCH2); 3.65(m, 2H, NCH2); 4.40(m, 1H, SCH); 1.78(m, 4H, OCH2CH2 and SCH(CH3)CH2); 1.40(m, 6H, NCH2CH3 and SCH(CH3)); 1.00(m, 6H, OCH2CH2CH3 and SCH(CH3)CH2CH3) Example 60: 8.70(s, 1H, CCH); 4.30(m, 2H, OCH2); 3.50(m, 1H, SCH) 3.20(d, 3H, NCH3); 1.80(m, 4H, OCH2CH2 and SCH(CH3)CH2); 1.50(m, 3H SCH(CH3)CH2CH3; 1.00(m, 6H, OCH2CH2CH3 and SCH(CH3)CH2CH3) Example 61: 8.80(s, 1H, COH); 4.80(m, 2H, OCH2); 3.95(m, 2H, NCH2); 3.58(m, 1H, SCH); 1.90(m, 2H, SCH(CH3)CH2); 1.62(m, 6H, NCH2CH3 and SCH(CH3)CH2CH3); 1.20(m, 3H, SCH(CH3)CH2CH3) Example 62: 8.70(s, 1H, COH); 5.10(m, 2H, OCH3CH2F); 4.80(m, 2H, OCH2 CH2F); 3.60(m, 1H, SCH); 3.10(d, 3H, NCH3); 1.78(m, 2H, SCH(CH3)CH2); 1.60(m, 3H, SCH(CH3)); 1.10(m, 3H, SCH(CH3)CH2-CH3) Example 63: 8.80(s, 1H, COH); 4.38(m, 2H, OCH2CH2CH3); 3.90(m, 2H, OCH2CH2OCH3); 3.60(s, 3H, OCH2CH2OCH3); 3.30(d, 3H, NCH3); 1.78(m, 2H, SCH(CH3)CH2CH2); 1.50(m, 3H, SCH(CH3)CH2-CH3); 1.10(m, 3H, SCH(CH3)CH2 CH3) Example 64: 8.75(s, 1H, COH); 7.0, 6.10 and 5,20(m, 1H, OCH2CF3CF2H); 4.60(m, 2H, OCH2); 3.60(m, 1H, SCH); 3.20(m, 3H, NCH3); 1.80(m, 2H, SCH(CH3)CH2CH3); 1.50(m, 3H, SCH(CH3)CH2-CH3); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 65: 9.30(d, 1H, CHS); 7.60(s, 4H, OC6H4-3CF3); 3.50(d, 3H, NCH3) 3.40(m, 1H, SCH); 1.78(m, 2H, SCH(CH3)CH2CH3); 1.50(m, 3H, SCH(CH3)) 1.00 (m, 3H, SCH(CH3)CH2CH3) Example 66: 9.35(d, 1H, CHS); 5.30(dd, 2H, NCH2SCH3); 4.40(m, 1H, OCH2); 3.50(m, 1H, SCH); 2.40(s, 3H, NCH2SCH3); 1.78(m, 2H, SCH(CH3)CH2); 1.60 (m, 6H, OCH2CH3 and SCH(CH3)CH2CH3); 1.00(m, 3H, SCH(CH3)CH2-CH3) Example 67: 9.30(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.50(d, 3H, NCH3); 2.90 (d, 2H, SCH2); 2.00(m, 1H, SCH2CH); 1.50(t, 3H, OCH2CH3); 1.00(d, 6H, SCH2CH(CH3)2) Example 68: 9.35(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.50(d, 3H, NCH3); 3.00(m, 2H, SCH2); 1.80(m, 2H, SCH2CH2); 1.58(m, 5H, SCH2CH2CH2 and OCH2CH3); 1.00(m, 3H, SCH2'CH2CH2CH3) Example 69: 9.35(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.50(d, 3H, NCH3); 3.00(m, 2H, SCH2); 2.00(m, 1H, SCH2CH2CH); 1.60(m, 2H, SCH2CH2); 1.45(t, 3H, OCH2CH3); 1.00(d, 6H, SCH2CH2CH(CH3)2) Example 70: 9.30(d, 1H, CHS); 4.50(m, 2H, OCH2); 4.60(d, 3H, NCH3); 3.00(m, 2H, SCH2); 1.70(m, 9H, OCH3CH3 and SCH2CH2CH2CH3); 1.00 (m, 3H, SCH2CH2CH2CH2CH3) Example 71: 9.30(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.50(d, 3H, NCH3); 2.90(m, 2H, SCH2); 2.00(m, 1H, SCH2CH(CH3)); 1.50(m, 8H, OCH2CH3 and SCH2CH(CH3)CH2CH3); 1.00(m, 3H, SCH2CH(CH3)CH2CH3) Example 72: 9.35(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.55(m, 1H, SCH); 3.50 (d, 3H, NCH3); 2.10(m, 2H, SCH(CH3)CH2); 1.60(m, 8H, OCH2CH3 and SCH(CH3)CH2CH2CH3); 1.10(m, 3H, SCH(CH3)CH2CH2CH3) Example 73: 9.30(d, 1H, CHS); 6.00(m, 1H, SCH2CH2CH=CH2); 5.30(m, 2H, SCH2CH2CH=CH2); 4.50(m, 2H, OCH2); 3.50(d, 3H, NCH3); 3.10(m, 2H, SCH2CH2CH=CH2); 2.65(m, 2H, SCH2) 1.60(t, 3H, OCH2CH3). Example 74: 9.30(d, 1H, CHS); 4.40(m, 2H, OCH2); 3.60(m, 2H, SCH2CH2 OCH3); 3.45(s, 3H, SCH2CH2OCH3); 3.40(d, 3H, NCH3); 3.00(m, 2H, SCH2); 1.45(t, 3H, OCH2CH3) Example 75: 9.30(d, 1H, CHS); 4.60(m, 2H, OCH2); 3.60(d, 3H, NCH3); 3.62(m, 1H, SCH); 1.78(m, 2H, SCH(CH3CH2); 1.50(m, 3H, SCH(CH3)); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 76: 9.30(d, 1H, CHS); 4.40(m, 4H, OCH2, NCH2); 3.50(m, 1H, SCH); 1.80(m, 4H, OCH2CH2 and SCH(CH3)CH2); 1.50(m, 6H, NCH2CH3 and SCH(CH3)CH2CH3); 1.10(m, 6H, OCH2CH2CH3 and SCH(CH3)CH2CH3) Example 77: 9.30(d, 1H, CHS); 4.30(m, 2H, OCH2); 3.50(d, 3H, NCH3); 3.50(m, 2H, SCH); 1.80(m, 4H, SCH(CH3)CH2 and OCH2CH2); 1.50(t, 3H, SCH(CH2)); 1.00(m, 6H, SCH(CH3)CH2CH3 and OCH2CH2CH3) Example 78: 9.30(d, 1H, CHS); 4.90(m, 2H, NCH2); 4.40(m, 2H, OCH3); 3.80(s, 3H, NCH2CO2CH3); 3.50(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2; 1.50(m, 6H, OCH2CH3 and SCH(CH3)CH2CH3); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 79: 9.28(d, 1H, CHS); 7.40(m, 5H, NCH2C6H5); 5.65(m, 2H, NCH2); 4.30(m, 2H, OCH2); 3.50(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2) 1.50(m, 6H, OCH2CH3 and SCH(CH3)CH2); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 80: 9.30(d, 1H, CHS); 7.40(m, 4H, NCH2C6H4F); 5.50(m, 2H, NCH2); 4.20(m, 2H, OCH2); 3.40(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2; 1.50 (m, 6H, OCH2CH3 and SCH(CH3)CH2); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 81: 9.30(d, 1H, CHS); 7.20(m, 4H, NCH2C6H4OCH3); 5.40(m, 2H, NCH2); 4.30(m, 2H, OCH2); 3.98(s, 3H, NCH2C6H4OCH3); 3.30(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2); 1.50(m, 6H, OCH2CH3 and SCH(CH3)CH2CH3); 1.00 (m, 3H, SCH(CH3)CH2CH3) Example 82: 9.30(d, 1H, CHS); 7.60(m, 4H, NCH2C6H4CF3); 5.70(m, 2H, NCH3); 4.40(m, 2H, OCH2); 3.50(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2); 1.50(m, 6H, OCH2CH3 and SCH(CH3)CH2; 1.10(m, 3H, SCH(CH3)CH2CH3) Example 83: 9.25(d, 1H, CHS); 4.50(d, 2H, NCH2); 4.40(m, 2H, OCH2); 3.70(t, 2H, NCH2CH2CH2Cl); 3.38(m, 1H, SCH); 2.40(m, 2H, NCH2CH2); 1.80(m, 2H, SCH(CH3)CH2); 1.50(m, 6H, OCH2CH3 and SCH(CH3)); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 84: 9.30(d, 1H, CHS); 7.50(m, 4H, NCH2SC6H4Cl); 4.40(m, 2H, OCH3); 3.60(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2); 1.50(m, 6H, OCH2CH3 and SCH(CH3)); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 85: 9.30(d, 1H, CHS); 5.60(m, 2H, NCH2C(Br)=CH2); 5.00(NCH2); 4.50(m, 2H, OCH2); 3.50(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2); 1.50 (m, 6H, OCH2CH3 and SCH(CH3)CH2); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 86: 9.30(d, 1H, CHS); 7.40(m, 5H, NCH2CH=CHC6H5); 6.60(m, 2H, NCH2CH=CH); 5.00(m, 2H, NCH2); 4.30(m, 2H, OCH2); 3.40(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2); 1.50(m, 6H, OCH2CH3 and SCH(CH3)); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 87: 9.30(d, 1H, CHS); 5.00(d, 2H, NCH2); 4.60(m, 4H, OCH2 and NCH2CO2CH2CH3); 3.60(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2); 1.50(m, 9H, OCH2CH3, NCH2CO2CH2CH3 and SCH(CH3); 1.20(m, 3H, SCH(CH3)CH2CH3) Example 88: 9.30(d, 1H, CHS); 4.38(m, 2H, OCH2CH2); 3.60(m, 2H, OCH2 CH2OCH3); 3.39(d, 3H, NCH3); 3.38(s, 3H, OCH3); 3.38(m, 1H, SCH); 1.80 (m, 2H, SCH(CH3)CH2); 1.38(t, 3H, SCH(CH3)); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 89: 9.35(d, 1H, CHS); 7.00, 6.00 and 5.20(m, 1H, HCF2CH2); 4.58 (m, 2H, OCH2CF2CF2H); 3.50(m, 1H, SCH); 3.50(d, 3H, NCH3) ; 1.80(m, 2H, SCH(CH3)CH2); 1.50(t, 3H, SCH(CH3)); 1.00(m, 3H, SCH(CH3)CH2CH3) Example 90: 9.35(d, 1H, CHS); 4.60(m, 2H, OCH2CF3); 3.60(m, 1H, SCH); 3.60(m, 2H, NCH2); 1.80(m, 2H, SCH(CH3)CH2); 1.60(m, 3H, SCH(CH3)); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 91: 9.30(d, 1H, CHS); 7.40(m, 5H, NCH2SC6H5); 5.60(d, 2H, NCH2); 4.40(m, 2H, OCH2); 3.60(m, 1H, SCH); 1.80(m, 2H, SCH(CH3)CH2); 1.60(m, 3H, OCH2CH3, SCH(CH3)); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 92: 9.30(d, 1H, CHS); 5.98(m, 2H, NCH2CH=CHCH3); 4.90(m, 2H, NCH3); 4.60(m, 2H, NCH2); 3.50(m, 1H, SCH); 1.90(m, 2H, SCH(CH3)CH2); 1.80(m, 3H, NCH2CH=CHCH3); 1.60(m, 3H, OCH2CH3, SCH(CH3)); 1.10(m, 3H, SCH(CH3)CH2CH3) Example 93: (d,1H,CHS); 7.870 (m,4H,NCH2C6H4); 5.40 (m,2H,,NCH2); 4.20 (m,2H,OCH2); 3.30 (m,1H,SCH); 1.00 (m,3H,SCH(CH3)CH2); 1.50 (m,6H,OCH2CH3 and SCH(CH3)); 1.00 (m,3H,SCH(CH3)CH2CH3); Example 120: 8.90 (s,1H,CHO); 4.40 (d,2H,NCH2); 4.38 (m,2H,OCH2); 3.85 (s,3H,NCH2CO2CH3); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1:60 (m,9H,OCH3CH3,SCH(CH3); 1.00 (m,3H,SCH(CH3)CH2CH3); Example 121: 8.85 (s,1H,CHO); 7.50 (m,5H,NCH2CH6H5); 5.00 (dd,2H, NCH2); 4.40 (m,2H,OCH3); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.60 (m,6H,OCH3 and SCH(CH3)); 1.00 (m,3H,SCH(CH3)CH2CH3); Example 122: 8.85 (s,1H,CHO); 7.40 (m,4H,NCH2C6H4); 4.90 (m,2H, NCH2); 4.40 (m,2H,OCH3); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.60 (m,6H,OCH3 and SCH(CH3)); 1.00 (m,3H,SCH(CH3)CH2CH3); Example 123: 8.90 (s,1H,CHO); 7.30 (m,4H,NCH2C6H4); 5.00 (dd,2H, NCH2); 4.40 (m,2H,OCH3); 3.90 (s,3H,OCH3); 3.59 (m,1H,SCH);1.80 (m,2H,SCH(CH3)CH2); 1.55 (m,6H,OCH3 and SCH(CH3)); 1.00 (m,3H, SCH(CH3)CH2CH3); Example 124: 8.85 (s,1H,CHO); 7.80 (m,4H,NCH2C6H4); 5.00 (dd,2H, NCH2); 4.38 (m,2H,OCH3); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.59 (m,6H,OCH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 125: 8.90 (s,1H,CHO); 4.40 (m,2H,OCH2); 3.90 (m,2H,NCH2); 3.80 (m,2H,NCH2CH2CH2Cl); 3.40 (m,6H,SCH); 2.38 (m,2H,NCH2CH2); 1.80 (m,2H,SCH(CH3)CH2); 1.55 (m,6H,OCH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 126: 8.90 (s,1H,CHO); 7.40 (m,4H,NCH2C6H4); 5.00 (d,2H, NCH2); 4.20 (m,2H,OCH3); 3.40 (m,1H,SCH); 1.75 (m,2H,SCH(CH3)CH2); 1.40 (m,6H,OCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 127: 8.90 (s,1H,CHO); 5.90 (m,2H,NCH2C(Br)=CH2); 4.60 (m,2H, NCH2); 4.40 (m,2H,OCH2); 3.50 (m,1H,SCH);1.80 (m,2H,SCH(CH3) CH2); 1.55 (m,6H,OCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 128: 8.90 (s,1H,CHO); 7.40 (m,5H,NCH2CH-CHC6H5); 6.80 (d,1H, NCH2CH=CH); 6.40 (m,1H,NCH2CH=CH); 4.60 (m,2H,NCH2); 4.40 (m,2H, OCH2); 3.50 (m,1H,SCH); 1.80(m,2H,SCH(CH3)CH2); 1.55 (m,6H,OCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 129: 8.90 (s,1H,CHO); 4.40 (d,2H,NCH2); 4.38 (m,4H,OCH2 and NCH2CO2CH2CH3); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.55 (m,9H,OCH2CH3,NCH2CO2CH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3) CH2CH3); Example 130: 8.85 (s,1H,CHO); 8:00 (m,4H,NCH2C6H4); 5.00 (d,2H,NCH2); 4.20 (m,2H,OCH2); 3.45 (m,2H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.50 (m, 6H,OCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 131: 8.90 (s,1H,CHO); 7.80 (m,4H,NCH2C6H4); 5.00 (dd,2H, NCH2); 3.40 (m,2H,OCH2); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3) CH2); 1.55 (m,6H,OCH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 132: 8.90 (s,1H,CHO); 8.00 (m,SH,NCH2COC6H4); 5.20 (d,2H, NCH2); 4.40 (m,2H,OCH3); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.55 (m,6H,OCHCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 133: 8.90 (s,1H,CHO); 7.50 (m,4H,NCH2C6H4); 5.00 (d,2H, NCH2); 4.40 (m,2H,OCH3); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.50 (m,6H,OCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 134: 8.90 (s,1H,CHO); 7.30 (m,4H,NCH2OC6H4); 5.70 (d,2H, NCH2); 4.20 (m,2H,OCH2); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.55 (m,6H,OCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 135: 8.90 (s,1H,CHO); 7.78 (m,7H,NCH2C10H7); 5.10 (dd,2H, NCH2); 4.00 (m,2H,OCH2); 3.40 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.60 (m,6H,OCH2CH3 and SCH(CH3)); 1.00 (m,3H,SCH(CH3)CH2CH3); Example 136: 8.90 (s,1H,CHO); 5.80 (m,2H,NCH2CH=CHCH3); 4.40 (m,4H, OCH2 and NCH2); 3.40 (m,1H,SCH); 1.60 (m,SH,SCH(CH3) and NCH2CH=CHCH3); 1.50 (m,6H,OCH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 137: 8.90 (s,1H,CHO); 7.48 (m,3H,NCH2C6H4); 5.30 (dd,2H, NCH2); 4.30 (m,2H,OCH2); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.50 (m,6H,OCH3CH2 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 138: 8.85 (s,1H,CHO); 5.10 (dd,2H,NCH2); 4.40 (m,2H,OCH2); 3.50 (m,1H,SCH); 1.80 (m,2H,SCH(CH3)CH2); 1.50 (m,6H,OCH2CH3 and SCH(CH3)); 1.10 (m,3H,SCH(CH3)CH2CH3); Example 139: 8.90 (s,1H,CHO); 4.40 (m,2H,OCH2); 3.50 (m,2H,NCH2); 2.75 (m,2H,SCH2); 1.50 (m,9H,NCHCH2CH2CH3,OCH2CH3 and SCHCH2CH3); 1.00 (m,3H,SCH2CH2CH3 and NCH2CH2CH2CH3); Example 140: 8.90 (s,1H,CHO); 7.39 (m,5H,NCH2C6H4); 4.80 (m,2H,NCH2); 4.00 (m,2H,OCH2); 2.70 (m,1H,SCH); 1.70 (m,2H,SCH(CH3)CH2); 1.20 (m,6H, SCH2CH2CH3 and OCH2CH3); Example 141: 8.90 (s,1H,CHO); 4.40 (m,6H,NCH2,OCH2,NCH2CO2CH2); 3.00 (m,1H,SCH2); 1.70 (m,2H,SCH2CH2); 1.20 (m,9H,SCH2CH2CH3,OCH2CH33 and NCH2CO2CH2CH3); Example 142: 8.85 (s,1H,CHO); 4.60 (m,4H,OCH2 and NCH2); 3.90 (m,2H, NCH2CH2Cl); 3.10 (m,2H,SCH2); 2.20 (m,2H,NCH2CH2); 1.80 (m,2H,SCH2CH2); 1.50 (m,3H,OCH2CH3); 1.00 (m,3H,SCH2CH2CH3); Example 143: 8.90 (s,1H,CHO); 7.80 (m,9H,NCH2C6H4OCH2C6H5); 5.30 (s,2H, NCH2C6H4OCH2); 5.00 (m,2H,NCH2); 4.40 (m,2H,OCH2); 3.40 (m,1H,SCH); 1.80(m,2H,SCH(CH3)CH2); 1.50 (m,6H,OCH2CH3 and SCH(CH3)); 1.00 (m,3H, SCH(CH3)CH2CH3); Example 145: 8.90 (s,1H,CHO); 5.10 (m,2H,NCH2C(CH3)=CH2); 4.30 (m,4H,OCH2 and NCH2); 3.50 (m,1H,SCH); 1.80 (s,3H,NCH(CH3)=CH2); 1.45 (m,6H,OCH2CH3 and SCH(CH3)); 1.00 (m,3H,SCH(CH3)CH2CH3); Table IV which follows sets forth the biological data obtained as described below for the exemplary compounds described in Table I. Initial evaluations are made on the following mite, insect, and nematode species: Code Symbol Common Name Latin Name TSM Two-spotted spider mite Tetranychus urticae GPA Green peach aphid Myzus persicae CRW Southern corn rootworm Diabrotica un decimpunctata howardi NEMA Southern root-knot Meloidogyne nematode incognita A test solution containing 600 ppm of test compound is prepared in an acetone:methanol:water system of 5:5:90 by volume. A test solution containing 150 ppm of test compound is prepared by diluting 1 part of the 600 ppm test solution with three parts of water. A 1:1 by weight mixture of alkylarlpolyetheralcohol (commercially available under the trademark TRITON X-155) and a modified phthalic glycerol alkyl resin (commercially available under the trademark TRITON B-1956) is utilized in the test solution in an amount of 28g (one ounce) per 378.5 1 (100 U.S. gallons) of test solution as a surfactant. For the mite test, infested bean (Phaseolus limeanus) leaf sections (¯ 2.5 x 2.5 cm) containing about 50 mites were placed in a Petri dish lid on a moistened piece of cotton. The leaves are then sprayed with the 600 ppm test solution using a rotating turntable. They are held for 24 hours and then the persent kill is determined. For the aphid test, infected broccoli (Brassica oleracea) leaf section (2.5 x 2.5 cm) containing about 30 adult and nymphal aphids are placed in a Petri dish lid on a moistened piece of cotton. The leaves are then sprayed with the 600 ppm test solution using a rotating turntable. They are held for 24 hours and then the percent kill is determined. For the rootworm larvae test, ten milliliters of the 150 ppm test solution are added to 200 milliliter of soil in a 473 ml jar to give a concentration by volume of about 8 ppm. The jar is shaken to ensure thorough mixing, immediately uncapped, and allowed to air for 2 hours. Two presoaked kernels of Golden Cross Bantam corn (Zea mays) are placed in the bottom of a plastic cup and covered with about 30 grams of treated soil. The soil surface is inoculated with approximately 120 southern corn rootworm eggs and the plastic cup closed with a tight-fitting cap. The test cap is held for 10 days at 270C and then the percent kill relative to the untreated check is determined. For the nematode test, soil is homogeneously inoculated with nematode eggs at the rate of about 5000 eggs per 200 milliliters of soil extracted from a macerated blend of tomato roots heavily knotted with the root knot nematode. Ten milliliters of the 150 ppm test solution are added to 200 milliliters of the inoculated soil in a 473 ml jar to give a concentration by volume of about 8 ppm. The jar is shaken to ensure thorough mixing, immediately uncapped, and allowed to air for 24 hours. The soil is then placed into a 7e 6Z cm plastic pot after which time 3 cucumber (Cucumis sativus) seeds are planted. About 23 days thereafter, the cucumber plants are removed from the soil and root system examined for the presence of knots. A total of 25 knots or less is considered as a measure of control. Excellent control is characterized by 0-2 knots. TABLE IV: Pesticidal Activity ' Control Soil Application Foliar Application (150 ppm) (600 ppm) Example CRW NEMA ' TSM . GPA 1 100 +++++ 100 98 2 100 - 100 50 3 100 - 0 0 4 65 +++++ 100 100 5 100 +++++ 100 100 6 100 +++++ 100 100 7 27 +++++ 0 0 8 100 +++ 100 95 9 100 - 100 NA 10 100 - 100 100 11 98 +++++ 81 0 12 100 - 100 100 13 100 ++++ 100 100 15 100 - 100 100 16 100 ++++ 100 73 17 100 ++++ 100 73 18 100 ++++ 100 50 19 100 +++++ 100 0 21 100 +++++ 100 100 22 100 +++++ 100 0 23 100 +++++ 100 0 24 100 +++++ 100 100 25 100 +++ 100 100 26 100 +++++ 100 100 27 100 +++++ 100 100 28 100 +++++ 100 100 29 100 +++++ 100 100 30 100 ++++ 100 100 31 100 +++++ 100 100 32 100 +++ 100 100 33 100 +++++ 100 100 34 100 +++++ 100 100 35 100 ++++ 100 100 36 100 +++++ 100 100 37 100 +++++ 100 100 38 100 - 100 95 39 100 +++++ 100 100 40 100 +++++ 100 100 41 100 +++++ 100 100 42 100 +++++ 100 100 43 100 +++++ 100 100 44 100 - 89 100 45 100 +++++ 100 100 46 100' +++++ 100 100 47 100 +F+++ 100 100 48 100 +++ 100 100 49 100 - 100 76 50 97 +++ 100 0 51 100 +++ 100 0 52 100 ++++ 100 0 53 96 - 100 29 54 100 - 100 NA 55 100 +++++ 100 NA 56 100 - 100 100 57 100 +++ 100 100 58 100 - - 100 40 59 100 0 0 100 60 100 ++ 59 100 61 100 - 97 0 62 100 ++++ 100 100 63 94 - 100 100 64 100 +++++ 100 83 65 100 - 100 100 66 100 ++++ 100 73 67 100 +++ 100 100 68 100 - 100- 11 69 100 - 100 0 70 83 - 100 93 71 100 - 100 100 72 100 - 100 100 73 70 - 100 100 74 100 - 100 100 75 100 ++++ 100 100 76 100 - 0 100 77 100 - 51 100 78 99 ++++ 100 100 79 100 ++ 100 100 80 100 - 100 100 81 100 - 100 100 82 100 ++ 100 100 83 100 - 100 100 84- - 100 - 100 ' 100 85 100 - 100 100 86 100 +++ 100 100 87 100 +++ 100 100 88 82 ++++F 100 100 89 100 +++++ 100 100 90 100 +++++ 33 0 91 - 100 - 100 100 92 100 - 100 100 93 90 - 100 100 94; 100 +++F+ 100 100 95 100 - 100 100 96 100 - 100 100 97 100 F++++ 100 100 98 89 +++++ 100 91 99 100 ++++ 100 100 100 100 - 100 100 101 100 +++++ 100 100 102 100 - 100 100 103 100 ++++ 100 100 104 100 ++++ 100 100 105 100 +++ 100 100 106 100 +++++ 100 100 107 100 *++++ 100 . 100 108 100 +++++ 100 100 109 100 - 100 100 110 100 ++++ 100 100 111 100 +++ 100 100 112 100 +++++ 100 100 113 100 +++++ 100 100 114 100 +++++ 100 100 115 98 +++++ 100 100 116 100 +++ 100 100 117 100 - 100 100 118 95 +++ 100 100 119 . 90 - 100 100 120 98 +++++ 100 100' 12.1 100 ++++ 100 100 122 100 ++ 100 100 123 100 - 100 100 124 100 - 100 100 125 100 - 100 100 100 - 100 100 126 127 100 +++ 100 NA 128 100 - 100 100 129 100 -- 100 100 130 - 1 100 - 100. 100 13 1 100 - 100 100 132 10'0 - 100 100. 133 100' - 100 100 134 100 - 100 100 135 100 - 100 100 136 100 - 100 95 137 100 - 100 100 138 100 - 100 100 139 100 ++ 100 100 140 100 - 100 100 141 100 ++++ 100 100 142 100 ++ 100 100 143 98 - 100 100 144 100 - 100 100 145 100 *+ 100 100 100 100 TABLE IV: Pesticidal Activity % Control ctd. CRW=Southern Corn Rootworm NEMA=Southern Rcot Knot Nematode TSM=Two Spotted Spider Mite GPA=Green Peach Aphid NA=Not Available TSM, & GPA-Test results expressed as % control. -Test results expressed as ranking for degree of knotting. Rank Knots 0-2 ++++ 3-6 +++ 7-9 ++ 18-25 - 25+

Claims: CLAIMS: 1. A compound having the formula: EMI69.1 wherein: R1 is (C1-C4) alkyl optionally substituted with one (C1-C4)alkoxy group and/or one to four of the same or different bromo, chloro or fluoro atoms; (C3-C6) alkenyl; (C3-C6) alkynyl; phenyl optionally substituted with from one to three of the same or different alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy, alkylthio, cyano, nitro, amino, or mono- or di-(C1-C3)alkylamino groups or atoms; or phenyl(C1-C5) alkyl, preferably phenyl (Cl-C3)alkyl, optionally ring-substituted with from one to three of the same or different alkyl, haloalkyl (preferably containing one to three o; the same or different halo atoms), halo, alkoxy, alkyl thio, cyano, nitro, amino, or mono- and di (C1-C3)alkylamino groups or atoms; R2 is (C2-C5) alkyl (or methyl when X and Y are both S) optionally substituted with from one to three of the same or different alkyl, halo, alkoxy, alkylthio, cyano, nitro, heterocyclic, amino, or mono- or di-(C1-C3)alkylamino groups or atoms; (C3-C6) alkenyl; CC3-C6) alkynyl; (C3-C6) cycloaliphatic or heterocyclo aliphatic; ; phenyl optionally substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy, alkylthio, cyano, nitro, amino and mono- or di-(C1-C3)alkylamino; phenyl (C1-C5)alkyl, preferably phenyl (C1-C3) alkyl, optionally ring-substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy alkylthio, cyano, nitro, amino and mono- or di- (C1-C3) alkylamino; 3 R is hydrogen; methyl; trifluoromethyl; alkoxy (C 1-C4 ) carbonyl; or alkoxy (C1-C4) thiocarbonyl; R4 is hydrogen; (C1-C7) alkyl optionally substituted with one to three of the same or different substituents selected from benzoyl alkoxy (Cl-C4)carbonyl, halo, alkoxy, alkylthio, cyano, nitro, and phenoxy or phenylthio each of the last two groups being optionally substituted with one to three of the same or different substituents selected from alkyl, alkoxy, halo, cyano, nitro, alkylthio, amino and mono- or di-(C1-C3)alkylamino; (C3-C6)alkenyl optionally substituted with one to three of the same or different substituents selected from alkoxy(C1-C4) carbonyl, phenyl, bromo, chloro and fluoro; (C3-C6) alkynyl; ; phenyl optionally ring-substituted with from one to five of the same or different halo atoms and/or up to three of the same or different substituents selected from alkyl containing one to'three of the same or different halo atoms, alkoxy, alkylthio, cyano, nitro, amino, and mono- or di-(C1-C3)alkylamino; or phenyl(or naphthyl) (C 1-C3)alkyl optionally ring-substituted with one to five of the same or different halo atoms and/or with up to three substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, alkoxy, alkylthio, cyano, nitro, benzyloxy, methylenedioxy, amino and mono- or di-(Cl-C3)alkylamino groups; and X, Y and Z are the same or different and are 0 or S, X and Y not both being 0 except for the case when (1) Y is S, (2) R is n-C5H7 or S-C4Hgt (3) R2 is S-C4Hgt (4) R3 is H and (5) R4 is methyl. 2. A compound as claimed in Claim 1, wherein R1 is other than alkoxy-substituted alkyl and X and Y are not both 0. 3. A compound as claimed in Claim 2, wherein: R1 is (C1-CX) alkyl optionally substituted with up to three substituents selected from F, C1, and Br; (C3-C6) alkenyl; (C3-C6) alkynyl, phenyl optionally substituted with up to three of the same or different substituents selected from F, Cl, Br, CH30, CH3S, CH3 CN, N02 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl(C1-C5)alkyl optionally ring-substituted or phenyl with up to three of the same or different substituents selected from F, CI, Br, CH3O,CH3S,CF3,CN,NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; Rê is (C2-H5) alkyl optionally substituted with up to three of the same or different substituents selected from F, Cl, Br, CH3O, CH3S, CF3, CN and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; (C3-C6) alkenyl; (C3-C6) alkynyl; (C3-C6) cycloaliphatic or heterocycloaliphatic; ; phenyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF , CN NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl(C1-C5) alkyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S,CN,NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; R is hydrogen; methyl; trifluoromethyl; alkoxy (C1-C4)carbonyl; or alkoxy (C1-C4)thiocarbonyl; R4 is hydrogen; straight chain (C1-C7) alkyl; straight or branched chain (C1-C7) alkyl substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN, N02 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3)alkyl; (C3-C6) alkenyl; (C3-C6) alkynyl; phenyl optionally substituted with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S, CF3, CN, N02 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl(C1-C5) alkyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CE3S, CF3, CN, NO2 and NR5R6 wherein R5 and 6 are the same or different and are H or (C1-C3) alkyl; and X, Y and Z are as defined in Formula I. 4. A compound as claimed in Claim 1, wherein: R1 is (1) (Cl-C4)alkyl optionally substiduted with fluorine or methoxy or (2) trifluoromethyl substituted phenyl, R2 is (C1-C5)alkyl (or methyl when X and Y are both S) optionally substituted with methoxy, C or 04-alkenyl or methyl-oxadiazolylmethyl, R3 is hydrogen, methyl or trifluoromethyl and R4 is (C1-C4)alkyl optionally substituted with chloro, methylthio, cyano, methoxycarbonyl, ethoxycarbonyl, benzoyl or phenylthio, the last group being optionally substituted with chloro; benzyl optionally ring-substituted with (a) up to five of the same or different substituents selected from fluorine, bromine and chlorine and/or (b) one or two of the same or different substituents selected from methoxy, trifluoromethyl, cyano, methyl, nitro, benzyloxy and methylenedioxy; naphthylmethyl; C3 or C 4-alkenyl optionally substituted with bromo or phenyl; and C3-alkynyl. 5. A compound as claimed in Claim 1 or 2, wherein R1 is methyl, ethyl, 2,2,2-trifluoroethyl, phenyl or benzyl; R2 is (C3-C5)alkyl, phenyl or benzyl; R3 is hydrogen, methyl, or trifluoromethyl; and R4 is methyl, ethyl, n-propyl, propenyl, or benzyl optionally substituted with from one to three of the same or different substituents selected from (C1-C3) alkyl, fluoro, chloro, bromo, methoxy, trifluoromethyl, nitro and cyano. 6. A compound as claimed in Claim 5, wherein R1 is methyl, ethyl, or 2,2,2-trifluoroethyl; R2 is n-propyl, 3-pentyl, or l-methylpropyl; R3 is hydrogen; R4 is methyl, ethyl, or benzyl ring-substituted with one or two of the same or different substituents selected from (C1-C3)alkyl, fluoro, chloro, bromo, methoxy, trifluoromethyl, nitro and cyano; and Z is 0. 7. A compound as claimed in Claim 6, wherein (a) R1 is ethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is ethyl, 3-trifluoromethylbenzyl or 4-fluorobenzyl, X is S and Y is 0, (b) R1 is 2,2,2-trifluoroethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is methyl, X is S and Y is 0, (c) R1 is ethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is ethyl, X is S and Y is S, (d) RÚ is ethyl, Rê is 1-methylpropyl, R is hydrogen, R4 is methyl, X is S and Y is O, or (e) RÚ is ethyl, Rê is l-methylpropyl, R3 is hydrogen, R4 is ethyl, X is 0 and Y is S. 8. A compound as claimed in Claim 1 wherein, R1 is methyl or ethyl, R2 is n-propyl, 3-pentyl, or l-methylpropyl, R3 is hydrogen, R4 is methyl or ethyl, X and Y are 0 or S and Z is S. 9. A compound as claimed in Claim 8, wherein (a) R1 is ethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is ethyl, X is 0 and Y is S, (b) R1 is ethyl, R2 is 1-methylpropyl,R is hydrogen,R4 is ethyl,X is S and Y is O or (c) RÚ is ethyl, Rê is 1-methylpropyl, R3 is hydrogen, R4 is ethyl, X is S and Y is S. 10. A method of combating pests (notably insects, nematodes and/or acarids) which comprises applying directly to the pests, or to the loci to be freed or protected from attack by the pests, a pesticidally effective amount of one or more compounds as claimed in any one of the preceding claims. 11. A pesticidal composition containing an active pesticidal component and a carrier or diluent therefor, wherein the active component comprises one or more compounds as claimed in any of Claims 1-9. CLAIMS: EMI77.1 1. A pesticidal composition containing an active pesticidal component and a carrier or diluent therefor, wherein the active component comprises one or more compounds having the formula: EMI77.2 wherein: R1 is (C1-C4) alkyl optionally substituted with one (C1-C4)alkoxy group and/or one to four of the same or different bromo, chloro or fluoro atoms; (C3-C6) alkenyl; (C3-C6) alkynyl; phenyl optionally substituted with from one to three of the same or different alkyl, haloalkyl containing one to three of the .same or different halo atoms, halo, alkoxy, alkylthio, cyano, nitro, amino, or mono- or di-(C1-C3)alkylamino groups or atoms; or phenyl(C1-C5) alkyl, preferably phenyl (C1-C3) alkyl, optionally ring-substituted with from one to three of the same or different alkyl, haloalkyl (preferably containing one to three of the same or different halo atoms), halo, alkoxy, alkyl thio, cyano, nitro, amino, or mono- and di (C1-C3)alkylamino groups or atoms; Rê is (C2-C5) alkyl (or methyl when X and Y are both S) optionally substituted with from one to three of the same or different alkyl, halo, alkoxy, alkylthio, cyano, nitro, heterocyclic, amino, or mono- or di-(C1-C3)alkylamino groups or atoms; (C3-C6) alkenyl; (C3-C6) alkynyl; (C3-C6) cycloaliphatic or heterocyclo aliphatic; ; phenyl optionally substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy, alkylthio, cyano, nitro, amino and mono- or di- (C1-C3) alkylamino; phenyl (C1-C5) alkyl, preferably phenyl (C1-C3)alkyl, optionally ring-substituted with from one to three of the same or different substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, halo, alkoxy alkylthio, cyano, nitro, amino and mono- or di-(C1-C3) alkylamino; 3 R is hydrogen; methyl; trifluoromethyl; alkoxy(C1-C4) carbonyl; or alkoxy (C1-C4) thiocarbonyl; R is hydrogen; ; (C1-C7) alkyl optionally substituted with one to three of the same or different substituents selected from benzoyl alkoxy (C1-C4)carbonyl, halo, alkoxy, alkylthio, cyano, nitro, and phenoxy or phenylthio each of the last two groups being optionally substituted with one to three of the same or different substituents selected from alkyl, alkoxy, halo, cyano, nitro, alkylthio, amino and mono- or di-(C1-C3)alkylamino; (C3-C6)alkenyl optionally substituted with one to three of the same or different substituents selected from alkoxy(C1-C4)- carbonyl, phenyl, bromo, chloro and fluoro; (C3-C6 ) alkynyl; ; phenyl optionally ring-substituted with from one to five of the same or different halo atoms and/or up to three of the same or different substituents selected from alkyl containing one to'three of the same or different halo atoms, alkoxy, alkylthio, cyano, nitro, amino, and mono- or di-(C1-C3)alkylamino; or phenyl(or naphthyl) (C1-C3)alkyl optionally ring-substituted with one to five of the same or different halo atoms and/or with up to three substituents selected from alkyl, haloalkyl containing one to three of the same or different halo atoms, alkoxy, alkylthio, cyano, nitro, benzyloxy, methylenedioxy, amino and mono- or di-(C1-C3)alkylamino groups; and X, Y and Z are the same or different and are 0 or S, X and Y not both being 0 except for the case when (1) Y is S, (2) R1 is n-C3H7 or S-C4Hg, (3) R2 is S-C H , (4) R3 is H and (5) R4 is methyl. 2. A composition as claimed in Claim 1, wherein R1 is other than alkoxy-substituted alkyl and X and Y are not both 0. 3. A composition as claimed in Claim 2, wherein: R1 is (C1-C4) alkyl optionally substituted with up to three substituents selected from F, C1, and Br; (C3-C6 ) alkenyl; (C3-C6) alkynyl; phenyl optionally substituted with up to three of the same or different substituents selected from F, Cl, Br, CH30, CH3S, CH3 CN, N02 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl(C1-C5)alkyl optionally ring-substituted or phenyl with up to three of the same or different substituents selected from F, Cl, Br, CH30, CH3S, CF3, CN, N02 and NR5R6 wherein R5 6 and R are the same or different and are H or (C1-C3( alkyl; R2 is (C2-H5) alkyl optionally substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; (C3-C6) alkenyl; (C3-C6) alkynyl; (C3-C6) cycloaliphatic or heterocycloaliphatic; ; phenyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF, CN 5R6 wherein R5 and R6 are the NO2 and NR R6 wherein R and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl(C1-C5)alkyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S,CN,NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3)alkyl; R3 is hydrogen; methyl; trifluoromethyl; alkoxy (C1-C4) carbonyl; or alkoxy (C1-C4) thiocarbonyl; R4 is hydrogen; straight chain (C1-C7) alkyl; straight or branched chain (C1-C7) alkyl substituted with up to three of the same or different substituents selected from F, C1, Br, CH3O, CH3S, CF3, CN, N02 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkenyl; (C3-C6) alkenyl; (C3-C6) alkynyl; phenyl optionally substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN, NO2 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; or phenyl (C1-C5) alkyl optionally ring-substituted with up to three of the same or different substituents selected from F, C1, Br, CH30, CH3S, CF3, CN, N02 and NR5R6 wherein R5 and R6 are the same or different and are H or (C1-C3) alkyl; and X, Y and Z are as defined in Formula I. 4 A composition as claimed in Claim 1, wherein: R1 is (1) (C1-C4)alkyl optionally substituted with fluorine or methoxy or (2) trifluoromethyl substituted phenyl, R2 is (C1-C)alkyl (or methyl when X and Y are both S) optionally substituted with methoxy, C3- or C4-alkenyl or methyl-oxadiazolylmethyl,R is hydrogen, methyl or trifluoromethyl and R4 is (C1-C4) alkyl optionally substituted with chloro, methylthio, cyano1 methoxycarbonyl, ethoxycarbonyl, benzoyl or phenylthio, the last group being optionally substituted with chloro; benzyl optionally ring-substituted with (a) up to five of the same or different substituents selected from fluorine, bromine and chlorine and/or (b) one or two of the same or different substituents selected from methoxy, trifluoromethyl, cyano, methyl, nitro, benzyloxy and methylenedioxy; naphthylmethyl; C3- or C4-alkenyl optionally substituted with bromo or phenyl; and C3-alkynyl. 5. A composition as claimed in Claim 1 or 2, wherein R1 is methyl, ethyl, 2,2,2-trifluoroethyl, phenyl or benzyl; R2 is (C3-C5)alkyl, phenyl or benzyl; 3 R is hydrogen, methyl, or trifluoromethyl; and R4 is methyl, ethyl, n-propyl, propenyl, or benzyl optionally substituted with from one to three of the same or different substituents selected from (C1-C3)alkyl, fluoro, chloro, bromo, methoxy, trifluoromethyl, nitro and cyano. 6. A composition as claimed in Claim 5, wherein R1 is methyl, ethyl, or 2,2,2-trifluoroethyl; Rê is n-propyl, 3-pentyl, or 1-methylpropyl, R is hydrogen; R4 is methyl, ethyl., or benzyl ring-substituted with one or two of the same or different substituents selected from CC1-C3)alkyl, fluoro, chloro, bromo, methoxy, trifluoromethyl, nitro and cyano; and Z is 0. 7. A composition as claimed in Claim 6, wherein (a) R1 is ethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is ethyl, 3-trifluoromethylbenzyl or 4-fluorobenzyl, X is S and Y is 0, (b) R1 is 2,2,2-trifluoroethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is methyl, Y. is S and Y is 0, (c) R1 is ethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is ethyl, X is S and Y is S, (d) RÚ is ethyl, Rê is 1-methylpropyl, R is hydrogen, R4 is methyl, X is S and Y is O, or (e) RÚ is ethyl, Rê is l-methylpropyl, R3 is hydrogen, R4 is ethyl, X is 0 and Y is S. 8. A composition as claimed in Claim 1 wherein, R1 is methyl or ethyl, R2 is n-propyl, 3-pentyl, or l-methylpropyl, R3 is hydrogen, R4 is methyl or ethyl, X and Y are 0 or S and Z is S. 9. A composition as claimed in Claim 8, wherein (a) R1 is ethyl, R2 is l-methylpropyl, R3 is hydrogen, R4 is ethyl, X is 0 and Y is S, (b) R1 is ethyl, R2 is 1-methylpropyl, R is hydrogen, R4 is ethyl,X and S and Y is O or (c) RÚ is ethyl, Rê is 1-methylpropyl, R3 is hydrogen, R4 is ethyl, X is S and Y is S. 10. A method of combating pests (notably insects, nematodes and/or acarids) which comprises applying directly to the pests, or to the loci to be freed or protected from attack by the pests, a pesticidally effective amount of one or more compounds as claimed in any one of the preceding claims.

Inventors: FITZPATRICK, JOSEPH MICHAEL, OLLINGER, JEANET, SMOLANOFF, JOEL ROBERT
Applicants: ROHM AND HAAS COMPANY
Application year: 1982
Main classification: C07F9
IPC codes: C07F9, A01N57