AGENT FOR TREATING CHRONIC OBLITERATIVE LUNG DISEASE

Abstract: An agent for treating chronic obliterative lung contain­ ing 5-methyl-7-diethylamino-s-triazolo(1,5-a)-pyrimidine as an effective ingredient, and a method for treating chronic obliterative lung disease by administration of said com­ pound in an effective dosage.

Description: SPECIFICATION Title of the Invention PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CHRONIC OCCLUSIVE PULMONARY DISEASES Technical Field This invention relates to a pharmaceutical composition for treating chronic occlusive pulmonary diseases and more specifically, to a pharmaceutical composition for treating chronic occlusive pulmonary diseases which contains as an active ingredient 5 methyl-7-diethylamino-s-triazolo-tl,5-a)-pyrimidine which has a remarkable pharmacological activity for the purpose of treating asthma. Background Art Asthma is characterized by an enhanced reactivity of trachea and bronchi against various stimuli, so that it is defined as disorders in which widespread constriction of respiratory tract is observed as a symptom [American Thoracic Society: Amer. Rev. Resp. Dis. 92, 513 (1965)j. More specifically, it is assumed that when a person is stimulated by specific allergens such as house dust, hogweed (Ambrosia elatior L.) and shellfish or by non-specific stimulations such as cold air, stimulative gas, bacterial infection, etc., granules are released from mast cells in the bronchial mucous membrane or from basophilic leukocytes in the blood, and the released granules in their turns liberate chemical mediators as histamine and SRS-A which stimulate adenocytes of the bronchi to induce supersecretion or dilation of blood vessels and to incite the increase of permeability finally causing the-person to become an edema or it is further assumed that the chemical mediators directly constrict the bronchial smooth muscles and narrow the inside of respiratory tract thereby inducing dyspnea. -In view of the above pathological processes, various methods for ameliorating symptoms of asthma have been tried. They include, for example, (1) the inhibition of specific reactions by allergens, i.e., an antigen-antibody reaction between the allergen and the antibody, (2) the inhibition of the liberation of chemical mediators from mast cells, and (3) the dilation of constricted respiratory tract and the acceleration for the removal of increased secretions. Various drugs based on these mechanisms are now used as clinical agents for treating asthma. Bronchodilators, such as xanthine derivatives and e- stimulants are most widely used among these agents. These agents, however, have the defect of causing very serious adverse reaction. For example, theophylline, a typical xanthine derivative, is a useful drug as long as it is highly effective against serious asthmatic attacks and those conditions which show resistance to bronchodilators. However, it is required to be administered with utmost care particularly in intravenous injection because it may induce palpitation, nausea, headache, vertigo, etc. and although rarely, induce anxiety of the breast, shock and cardiac arrest causing to death On the other hand, bronchodilators typified by isoproterenol cause inevitable adverse reactions, i.e. the enhancement of heart function and the reduction of blood pressure, owing to its stimulating action for the S-receptor of sympathetic nerve system which is the receptive site for the pharmacological action of these drugs. Hence, the administration of the bronchodilators to aged patients is prohibited, particularly when they are complicated with coronary insufficiency, angina pectoris, and arteriosclerosis of medium or higher degree. For this reason, drugs of this type are unsuitable as systemic agents, and are used mainly as inhalants. Furthermore, since these drugs are to be used only at the time when the asthmatic attack occurs and cannot be used for prophylaxis of attack, they are unable to eliminate the causes which disturb comfortable sleep. Disclosure of the Invention The present inventors have made extensive investigations in order to develop a drug which has an excellent therapeutic effect against asthma without serious adverse reaction. Consequently, it has been found that 5-methyl-7-diethylamino-s-triazolo(l,5-a)- pyrimidine (commonly known as "Trapidil" which is abbreviated TR hereinbelow) has an ameliorating action for bronchial constriction and stricture which are the fundamental causes of the pathological processes of asthma by using experimental models in animals which are now considered to be the most objective methods of evaluating agents for treating asthma. This discovery has led to the present invention. TR is a known compound represented by the following formula (I): EMI4.1 It is a white to slightly yellowish white crystalline powder with a bitter taste which is readily soluble in water andorganic solvents and has been known to have various activities for improving circulatory systems, for example vasodilating activity for coronary artery [Koroku Hashimcto et al., "Oyo Yakuri" (Pharmacometrics), 8, 33 (1974)], inhibitory activity of platelet aggregation (Hiroshi Kosuzume et al., "Toho Igakukai Si" (Journal of the Medical Society of Toho University), 26, 674 (1979)] and an ameliorating activity of lipid metabolism [Haruo Ohnishi et al., "ichi Yakuri Shi" (Folia Pharmacologica Japonica), 76, 469 (1980)1. The pharmacological activities of TR will now be illustrated below by experimental examples. Experimental Example 1 Activities for relaxing smooth muscles of isolated trachea and stimulating isolated atrium: Hartley-strain make guinea pigs weighing 400 to 500 g were killed and the trachea and the right atrium were isolated. A preparation of the isolated trachea prepared by the method of Takagi et al. [Takagi, K. et al., Chem. Pharm. Bull., 6, 716 (1958)] was suspended in Tyrode's solution at 370C into which air was passed. The preparation of the trachea was made to contract by the addition of histamine (10 6M), and thereafter the relaxing of the preparation by the addition of the respective test drugs was recorded by a kymographion through a writing lever. On the other hand, a preparation of the isolated atrium was suspended in Krebs-Henseleite's solution at 30 C, while there was passed into this solution oxygen containing 5% carbon dioxide. Increase in heart contractile force and heart rate by the addition of the respective test drugs were recorded by a polygraph through a strain gauge. The experiments were carried out using three preparations obtained from different -animals at each of the concentrations of the drugs, and mean values were calculated. The results are shown in Table 1 and Figure 1. Table 1 Percent Percent Percent relaxing increse percent Concentra- ratio in heart increse tion (mol) of the contract- in heart rate trachea ile force rate 1x10-5 18 0 0 TR 3 x 10-5 5 93 4 3 1x10-4 200 11 7 1 x 10-5 5 0 0 Theophylline 3 x 10-5 5 32 4 2 1 x 10 4 108 11 8 . x 10 108 11 8 1 x 10 9 0 21 13 Isoproterenol 1 x 10-8 0 35 28 1 x 10 7 123 60 64 The activity of TR for relaxing trachea contracted by histamine was three times as high as that of theophylline, and the activity of TR for enhancing heart function was equivalent to that of theophylline. In other words, TR has three times greater selectivity for trachea as theophylline. On the other hand, isoproterenol accelerated heart function even at a very low concentration at which it did not show any activity for relaxing trachea. Experimental Example 2 Bronchodilating action in dog in situ: In the foregoing Experimental Example 1, the inhibitory action of TR for the contraction of an isolated trachea of a guinea pig was described. However, it is desirable in order to determine the utility of TR as an agent for treating asthma by systemic administration, to examine the activity of the drug in vivo or in situ. Thus, the inhibitory activity of TR for the contraction of bronchi in situ was examined using dogs. The experiment was carried out in accordance with the Konzett Rdessler's method [Konzett, H. and Röessler, R: Arch. Exp. Pathol. Pharmacol., 195, 71 (1940)]. Six mongrel adult dogs were anesthetized with pentobarbital sodium (30 mg/kg). A tracheal cannula was inserted, and under artificial respiration, holes were incised in the right and left pleurae to equalize the pressure of the pleural cavity to the atmospheric pressure. The amount of air which overflowed by inspiration against a pressure of 10'1 cm H2O applied from the branch of the cannula was measured by a pneumotachograph. The inhibitory action of TR on the increase of the overflowing air due to the intravenous administration of histamine dihydrochloride (2 vg/kg) was taken as an index of the efficacy of TR. The administration of TR was conducted intravenously for two minutes berore the administration of histamine dihydrochloride. The results are shown in Table 2. TR remarkably inhibited the histamine-induced contraction of the bronchi of dogs, and its activity was greater than that of theophylline. Table 2 Dose Percent Drug (mg/kg) inhibition Control 0 TR 0.3 27 1.0 48 3.0 87 Theophylline 3.0 56 Experimental Example 3 The selectivity of the dilating activity of TR for trachea was compared with those of isoproterenol and theophylline. Preparations of blood-perfused trachea in situ were prepared by the method of Himori and Taira [Himori, N., Taira, N., Brit. J. Pharmacol., 56, 293 (1976)] as follows. Nine mongrel adult dogs weighing between 10 to 15 kg were anesthetized by the intravenous administration of pentobarbital sodium (30 mg/kg). The cervix of each dog was medisected to expose the pharynx and the upper part of the trachea. A cannula was inserted into the both superior thyroid arteries, and the vascular bed of the trachea was perfused with arterial blood. The blood was introduced from the femoral artery by a peristaltic pump, and a part of the blood stream was by-passed to the downstream of the femoral artery through a Starling's air resistance tube provided parallel to the vascular bed of the trachea, thereby performing the perfusion under a constant pressure. The pressure of the perfusion was kept a little higher than the mean aortic blood pressure. The blood flow (the amount of blood flow in the vascular bed of the trachea) flowing into the both superior thyroid arteries were measured by an electromagnetic flow meter. On the other hand, water was placed into the cuff of a tracheal tube equipped with a cuff, and the tube was inserted into the trachea. Then, the inside pressure of the cuff was measured by a pressure transducer to determine the inside pressure of the trachea as follows. Initially, water was placed in the cuff in such a manner that the static inside pressure of the trachea was about 40 cm H2 0. During the experiment, the tonus (the inside pressure of the trachea) of the tracheal smooth muscles in stationary phases was maintained by continuous intraarterial injections of 3 pg each of neostigmine into the vascular bed of the trachea at 30-minute intervals. TR, isoproterenol [(-) isoproterenol hydrochloride] and theophylline were respectively dissolved in 0.9% aqueous solution of sodium chloride, and injected intraarterially by a microsyringe. To the isoproterenol hydrochloride solution was added ascorbic acid in an equimolar amount in order to prevent oxidation. TR, isoproterenol and theophylline increased the blood flow in the trachea and reduced the inside pressure of the trachea in a dose dependent manner. As an index of the selectivity of the dilating activity for trachea, the ratio of the increase of the blood flow in the trachea to the decrease of the inside pressure of the trachea was determined. The selectivity of TR was about 3 times as high as that of isoproterenol. On the other hand, in this experiment, the selectivity of TR was the same as that of theophylline, but the dilating activity for trachea and the increasing activity for tracheal blood flow of TR were about 3 times as high as those 'of theophylline. Accordingly, TR, unlike sympathomimetic drugs such as isoproterenol, is useful not only for the treatment of asthma but also for the prophylaxis of asthma by oral administration. Experimental Example 4 Acute toxicity TR was administered either orally, subcutaneously or intravenously to ICR-strain mice or Wistar-strain rats, and its acute toxicity was examined. LD50 was calculated from the mortality rate according to the method of Litchfield-Wilcoxon after three days from the administration. The results are shown in Table 3. It was proved that TR is a highly safe compound having a high LD50 value as compared with the doses which exhibit its efficacy. Table 3 Oral Oral Ad- Subcutaneous Intravenous Animal Sex rffinistration administration administration species (mg/kg) (mg/kg) (m.g/kg) mouse male 740 267 101 mouse female 710 253 113 rat male 750 167 125 rat female 570 157 113 Experimental Example 5 (Clinical Test) TR was administered to patients with chronic occlusive pulmonary disorders such as bronchial asthma to examine its effect for improving occlusive troubles. TR was administered orally three times in a dose of 150 mg/day or in some cases 300 mg/day to patients with bronchial asthma, chronic pulmonary emphysema, complication of these, and chronic bronchitis who had been treated with the drugs shown in Table 4 for several months but had not shown a clear objective or subjective improvement. Before and after the administration, the spirogram and the flow volume curve were recorded to examine the function of the lungs. Furthermore, blood examination and general biochemical tests were performed as required. The results are shown in Table 5. The improvement of the function of patients with chronic bronchial asthma, etc. by long-term administration should be evaluated carefully because there exists marked time-dependent variation in the condition of the patients including intradaily variation. In order to examine the acute effect of TR, 100 mg of TR was administered intravenously to a healthy young male without an anamnesis of respiratory diseases, and forced vital capacity (FVC) was checked before and after the administration (Figure 2 and Table 5). As shown in Table 5, an increase by 0.46 liters in FVC and 0.32 liters in the one second vital capacity (FEV1 0) was observed. In the flow volume curve; the peak flow rate (PFR), V.75 and V.50 showed an apparent increase after the intravenous administration, but V.25 and V.10 showed a decrease after the intravenous administration. This suggests that TR has a greater dilating effect on larger respiratory tracts. In cases 1 and 2 with asthma, PFR which is regarded as an index reflecting the seriousness of the occlusion of larger respiratory tracts showed an apparent increase after the administration of TR. This shows that as was noted in the healthy person, TR has improving effects on the functional constriction of larger respiratory tracts. In cases 4 and 5 mainly with pulmonary emphysema, PFR and FEZ1 0 decreased although an increase in FVC by 0.44 liters and 0.3 liters was noted. This is presumably due to the aggravation of the occlusion of expiration caused by the relaxing of the bronchial muscles of larger respiratory tracts, i.e. the decrease of the tonus of the tracts, with TR. Occlusive disorders in chronic pulmonary emphysema, unlike bronchial asthma, chronic bronchitis, etc., is caused mainly by the occlusion of expiration due to the decrease in pulmonary elastic contracting pressure, and the tonus of the respiratory tracts itself is related to the occlusion of expiration. In all cases, the FVC evidently increased after the administration of TR, and an increase in FEV1 0 was observed in four cases excepting the cases 4 and 5 of pulmonary emphysema. Further, TR was administered to a patient with malignant chronic asthma, who had been bothered by continuous wheezing for a year. The thoracic X-ray pattern of the patient indicated that the diameter in the origin of right pulmonary artery was 23 mm and the electrocardiogram showed pulmonary P. This case is described separately from the above cases, because the patient showed severe dypnea, so that the test for pulmonary function could not be performed before the administration of TR. After the administration of TR in this case, subjective symptoms greatly improved, and a marked decrease in whistling and rattling was objectively noted by ausculation. In all cases, neither abnormality in liver function and peripheral blood, nor other adverse effects were observed. Table 4 EMI13.1 <tb> <SEP> Dose <SEP> Admini- <SEP> Drugs <SEP> used <tb> Case <SEP> Age <SEP> Sex <SEP> Diagnosis <SEP> (mg/ <SEP> stration <SEP> in <SEP> combination <SEP> with <tb> <SEP> day) <SEP> period <SEP> TR <tb> <SEP> (days) <tb> <SEP> Mucolytic <SEP> agent <SEP> for <tb> <SEP> mucus <SEP> in <SEP> respiratory <tb> <SEP> tract, <SEP> ant <tb> <SEP> 1 <SEP> 56 <SEP> Male <SEP> Bronchial <SEP> 150 <SEP> 360 <SEP> inflammatory, <SEP> enzyme <tb> asthma <SEP> preparation, <SEP> broncho <tb> <SEP> dilator, <SEP> steroid <tb> <SEP> Bronchial <tb> <SEP> asthma, <tb> <SEP> 2 <SEP> 54 <SEP> Female <SEP> recurrent <SEP> 150 <SEP> 74 <SEP> None <tb> <SEP> nerve <tb> <SEP> paralysis <tb> <SEP> Bronchial <SEP> Mucolytic <SEP> agent <SEP> for <tb> asthma, <SEP> mucos <SEP> in <SEP> respiratory <tb> <SEP> 3 <SEP> 54 <SEP> Male <SEP> chronic <SEP> 300 <SEP> 25 <SEP> tract, <SEP> anti <SEP> pulmonary <SEP> inflamatory <SEP> enzyme <tb> <SEP> emphysema <SEP> insufficiency <tb> <SEP> Chronic <SEP> Bronchodilator, <SEP> agent <tb> 4 <SEP> 68 <SEP> Male <SEP> pulmonary <SEP> 150 <SEP> 112 <SEP> for <SEP> treating <SEP> cardiac <tb> <SEP> emphysema <SEP> insufficiency <tb> <SEP> Mucolytic <SEP> agent <SEP> for <tb> <SEP> Chronic <SEP> mucus <SEP> in <SEP> respiratory <tb> <SEP> 5 <SEP> 65 <SEP> Male <SEP> pulmonary <SEP> 150 <SEP> 34 <SEP> tract, <SEP> anti-angina <tb> <SEP> emphysema <SEP> agent, <SEP> cardiac <SEP> agent <tb> <SEP> Chronic <SEP> Mucolytic <SEP> agent <SEP> for <tb> bronchitis, <SEP> mucus <SEP> in <SEP> respiratory <tb> <SEP> 6 <SEP> 69 <SEP> Male <SEP> broncho- <SEP> 150 <SEP> 82 <SEP> tract, <SEP> anti <tb> dilation <SEP> inflammatory <SEP> enzyme <tb> <SEP> preparation, <tb> bronchodilator <tb> Table 5 EMI14.1 <SEP> FVC <SEP> (l) <SEP> FEV1.0 <SEP> (l) <SEP> FEV1.0 <SEP> (%) <SEP> PFR <SEP> (l/sec) <SEP> V.25 <SEP> (l/sec) <tb> Case <SEP> Changes <SEP> in <SEP> clinical <SEP> condition <tb> <SEP> Before <SEP> After <SEP> Before <SEP> After <SEP> Before <SEP> After <SEP> Before <SEP> After <SEP> Before <SEP> After <tb> 1 <SEP> Improved <SEP> 2.75 <SEP> 2.77 <SEP> 1.69 <SEP> 1.78 <SEP> 61.4 <SEP> 64.2 <SEP> 4.09 <SEP> 4.89 <SEP> 0.58 <SEP> 0.46 <tb> <SEP> Improved <SEP> (an <SEP> attack <SEP> of <tb> 2 <SEP> dysphes <SEP> in <SEP> the <SEP> early <SEP> morning <SEP> 2.44 <SEP> 3.58 <SEP> 1.70 <SEP> 2.72 <SEP> 69.8 <SEP> 75.9 <SEP> 2.69 <SEP> 4.05 <SEP> 0.59 <SEP> 1.31 <tb> <SEP> was <SEP> alleviated <tb> <SEP> Slightly <SEP> improved <SEP> (short) <tb> 3 <SEP> breath <SEP> during <SEP> body <SEP> movement <SEP> 1.37 <SEP> 2.37 <SEP> 0.44 <SEP> 0.77 <SEP> 31.7 <SEP> 32.4 <SEP> 1.67 <SEP> 2.50 <SEP> 0.12 <SEP> 0.11 <tb> <SEP> was <SEP> alleviated) <tb> 4 <SEP> No <SEP> change <SEP> 2.64 <SEP> 3.08 <SEP> 0.71 <SEP> 0.60 <SEP> 26.9 <SEP> 19.4 <SEP> 1.49 <SEP> 2.12 <SEP> 0.21 <SEP> 0.16 <tb> <SEP> Slightly <SEP> improved <SEP> (short <tb> 5 <SEP> breath <SEP> during <SEP> body <SEP> movement <SEP> 1.09 <SEP> 1.39 <SEP> 0.42 <SEP> 0.42 <SEP> 38.2 <SEP> 30.2 <SEP> 1.43 <SEP> 1.06 <SEP> 0.13 <SEP> 0.05 <tb> <SEP> was <SEP> alleviated <tb> 6 <SEP> Slightly <SEP> improved <SEP> 2.07 <SEP> 2.60 <SEP> 1.23 <SEP> 1.40 <SEP> 59.3 <SEP> 53.8 <SEP> 3.55 <SEP> 3.73 <SEP> 0.39 <SEP> 0.38 <tb> Average <SEP> 2.06 <SEP> 2.63 <SEP> 1.03 <SEP> 1.28 <SEP> 47.8 <SEP> 45.9 <SEP> 2.65 <SEP> 3.05 <SEP> 0.33 <SEP> 0.41 <tb> <SEP> #0.62 <SEP> #0.67 <SEP> #0.53 <SEP> #0.79 <SEP> #16.2 <SEP> #20.1 <SEP> #0.94 <SEP> #1.28 <SEP> #0.19 <SEP> #0.42 <tb> <SEP> Healthy <SEP> person <SEP> 4.07 <SEP> 4.53 <SEP> 3.82 <SEP> 4.14 <SEP> 93.8 <SEP> 91.4 <SEP> 10.66 <SEP> 11.09 <SEP> 3.15 <SEP> 2.80 <tb> FVC: forced capacity, FEV1.0%: one second ratio, PFR: peak flow rate, V.25: the flow rate of 25% VC, FEV1.0: one second vital capacity The above Experimental Examples led to the conclusion that in the experimental models of trachial and bronchial contraction, TR apparently shows an inhibitory activity for the contraction and its action is selective for tracheal muscles suggesting that TR may be used in the treatment of asthma or chronic obstructive pulmonary diseases with bronchial constriction, for example, chronic bronchitis or chronic emphysema. It has been recognized that from the comparison between effective doses and LD50 values in the experimental examples in situ, the safety of TR is high. Brief Description of the Drawings Figure 1 is an example of a graph which shows the contracted state of isolated trachea sample by histamine and the relaxed state of the sample by Trapidil or theophylline in Experimental Example 1. Figure 2 is a flow volume curve of a healthy young male before and after the administration of Trapidil in Experimental Example 5. Best Mode for Carrying Out the Invention It has been found that TR has a dilating activity for trachea and bronchi quite independently of the known pharmacological activities such as its ameliorating activity for circulatory systems e.g. vasodilating activity of coronary arteries, inhibitory activity of platelet aggregation or ameliorating activity of lipid metabolism and therefore it is useful as an agent for the treatment of chronic occlusive pulmonary diseases. The dose of TR as an agent for the treatment of chronic occlusive pulmonary diseases may be usually 150 to 600 mg (oral agents), 50 to 200 mg (injections) or 10 to 5Q mg (inhalant) per day, but may be properly increased or decreased according to the condition, age and sex of patients. In the clinical use of TR according to this invention, it is formulated in a customary manner into tablets, capsules, aerosols, syrups or injections. It may also be in other forms such as granules and powders The formulation into these preparation forms can be carried out by conventional methods with acceptable carriers or excipients. Some examples of the formulations are shown below without any intention of limiting it to these specific examples, Example 1 Tablets: (I) TR 50 g (11) Lactose suitable amount CITE) Crystalline cellulose 60 g (IV) Potato starch 54 g (V) Magnesium stearate 2 g The ingredients (I) to (IV) were mixed, and a part of the ingredient (1V) previously separated was added as a 10% starch paste, and the mixture was formed into granules. The granules were dried, and the remaining powder which did not form granules was removed by sieving. The ingredient (V) was added to the granules and they were mixed. Tablets of the weight of 200 mg were prepared from the mixture by a tableting machine. As required, the tablets may be sugar-coated as usual. Example 2 Capsules: (I) TR 50 g (II) Calcium phosphate 50 g (E) Aluminum silicate suitable amount (IV) Crystalline cellulose 60 g (V) Magnesium stearate 2 g The ingredients (I) to (V) were mixed and sieved for further mixing. The mixture was formed into capsules each having a weight of 200 mg in accordance with a conventional method. Example 3 Aerosols: (I) TR 1.5% (II) Ascorbic acid 0.10 (III) Ethyl alcohol 35.75 (IV) Freon 114 sufficient amount The ingredients (I) and (II) were dissolved in 95% ethyl alcohol (m), and the solution was placed into containers together with the ingredient (IV) in a customary manner. Example 4 Injections: One hundred grams of TR crystals were dissolved in 2 liters of distilled water for injection, and the solution was formed into injections (100 mg/2 ml per ampoule). Industrial Applicability This invention is useful for pharmaceutical composition for treating of chronic occlusive pulmonary diseases

Claims: What Is Claimed Is 1. A pharmaceutical composition for the treatment of chronic occlusive pulmonary diseases comprising 5-methyl-7-diethylamino s-triazolo-(1,5-a)-pyrimidine as active ingredient in association with a pharmaceutically acceptable carrier. 2. A pharmaceutical composition as claimed in claim 1, wherein the chronic occlusive pulmonary disease is asthma. 3. A pharmaceutical composition as claimed in claim 1 or 2 comprising active ingredient and liquid or solid carrier. 4. A pharmaceutical composition as claimed in claim 1, 2 or 3, wherein the composition is in the form of an oral preparation. 5. A pharmaceutical composition as claimed in claim 4, wherein the composition is one selected from a tablet, capsule, syrup, granule or powder 6. A pharmaceutical composition as claimed in claim 1, 2 or 3, wherein the composition is in the form of an injection or an inhalant. 7. A pharmaceutical composition as claimed in any one of claims 1 to 6, wherein the composition is formulated so that the daily dosage for the active ingredient ranges from 10 to 600 mg. 8. Therapeutic method for the treatment of chronic occlusive pulmonary diseases comprising administering therapeutically effective amount of 5-methyl-7-diethylamino-s-triazolo- (1,5-a) - pyrimidine. 9. Therapeutic method as claimed in claim 8, wherein the chronic occlusive pulmonary disease is asthma. 10 Therapeutic method as claimed in claim 8 or 9, wherein the therapeutically effective amount per day is 19 to 600 mg. 11 Therapeutic method as claimed in claim 8 or 9, wherein the therapeutically effective amount of 5-methyl-7-diethylamino s-triazolo- (1,5-a) -pyrimidine is orally administered. 12. Therapeutic method as claimed in claim 11, wherein the therapeutically effective amount per day is 150 to 600 mg 13. Therapeutic method as claimed in claim 8 or 9, wherein the therapeutically effective amount of 5-methyl-7-diethylamino s-triazolo-(1,5-a)-pyrimidine is administered by injection. 14. Therapeutic method claimed in claim 13, wherein the therapeutically effective amount per day is 50 to 200 mg. 15. Therapeutic method claimed in claim 8 or 9, wherein the therapeutically effective amount of 5-methyl-7-diethylamino s-triazolo-(1,5-a) -pyrimidine is inhaled. 16. Therapeutic method claimed in claim 15, wherein the therapeutically effective amount per day is 10 to 50 mg.

Inventors: ITOU, CHIHIRO, MOCHIDA, EI, OHNISHI, HARUO, TAIRA, NORIO
Applicants: MOCHIDA PHARMACEUTICAL CO., LTD.
Application year: 1982
Main classification: A61K31
IPC codes: A61K31, A61P11, C07D487