N-NAPHTHOYLGLYCINE DERIVATIVES

Abstract: Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications. The derivatives are of the formula (where R¹ is hydrogen lower alkyl, lower alkenyl or phenyl­ methyl, R² is hydrogen or lower alkyl and R³, R⁴ and R⁵ are hydrogen or specified substituents) and therapeutically acceptable salts of the compounds wherein R² is hydrogen. Certain intermediate aminoacids useful in the preparation of the above mentioned derivatives also have aldose reductive inhibiting effects.

Description: N-NAPHTHO YLG LY CIN E DERIVATIVES This application relates to Nsaphthoylglycine derivatives, therapeutically acceptable salts thereof, a process for their preparation, and to methods of use and to pharmaceutical compositions thereof. The derivatives have pharmacologic properties which render them beneficial for the treatment of diabetes mellitus and associated conditions. For many years diabetes mellitus has been treated with two established types of drugs, namely insulin and oral hypoglycemic agents. These drugs have benefited hundreds of thousands of diabetics by improving their well-being and prolonging their lives. However, the resulting longevity of diabetic patients has led to complications such as neuropathy, nephropathy, retinopathy, cataracts and atherosclerosis. These complications have been linked to the undesirable accumulation of sorbitol in diabetic tissue, which in turn result from the high levels of glucose characteristic of the diabetic patient. In mammals, including humans, the key enzyme involved in the conver sion of hexoses to polyols (the sorbitol pathway) is aldose reductase. J.H. Kinoshita and collaborators, see J.H. Kinoshita et al., Biochem. Biophys. Acta, 158, 472 (1968) and references cited therein, have demonstrated that aldose reductase plays a central role in the etiology of galactosemic cataracts by effecting the conversion of galactose to dulcitol (galactitol) and that an agent capable of inhibiting aldose reductase can prevent the detrimental accumulation of dulcitol in the lens. Furthermore, a relationship between elevated levels of glucose and an undesirable accumulation of sorbitol has been demonstrated in the lens, peripheral nervous cord and kidney of diabetic animals, see A. Pirie and R. van Heyningen, Exp. Eye Res., 3, 124 (1964); L.T. Chylack and J.H. Kinoshita, Invest. Ophthal., 8,401 (1969) and JD. Ward and R.W.R. Baker, DiabetoL, 6, 531(1970). l,3-Dioxo-lH-benz[de] isoquinoline-2(3H)-acetic acid has been reported to be an effective inhibitor of aldose reductase, see D. Dvornik et al., Science, 182, 1146 (1973), and to be useful for the treatment of diabetic complications such as diabetic cataracts, neuropathy, nephropathy and retinopathy, see K. Sestanj, N. Simard-Duquesne and D.M. Dvornik, U.S. Patent No. 3,821,383, June 28, 1974. (S)-8-Fluoro-2,3-dihydrospiro(4H- 1-benzopyran-4,4'-imidazolidine)-2',5'-dione (sorbinil) is still another compound that has received attention because of its aldose reductase inhibiting properties (see M.J. Peterson et al., Metabolism, 28 (Suppl. 1), 456 (1979). Accordingly, these compounds represent an important new approach for the treatment of diabetes mellitus. The present application discloses novel N-naphthoylglycine derivatives, represented below by formula I, which are effective inhibitors of aldose reductase. These new derivatives are structurally quite different from the above noted aldose reductase inhibitors. Close prior art compounds, on a structural basis, appear to be a group of thioacylaminoacids, e.g. N-phenylthioxomethyl-N-methyl- glycine, prepared by A. Lawson and C.E. Searle, J. Chem. Soc., 1556 (1957) as part of a chemical investigation of the chemical properties of such compounds. These last mentioned compounds were prepared by thiobenzoylation of various amino acids with (thiobenzoylthio)acetic acid. An important structural difference between these compounds and the present derivatives is the different type of aromatic group substituted on the thione portion of the thioamide. Thioacylamides also have been reported [see Chem. Abstr., 86,189582f 977) for VJ. Cohen et al., Bur. J. Med. Chem., 5, 480 (1976) and Chem. Abstr., 70, 11306a (1969) for von J. Voss and W. Walter, Justus Leibigs Ann. Chem., 716, 209 (1968)1. The structures of the thioacylamides of Cohen et al and Voss et al differ from the structure of the present derivatives by having at least a different type of N-substitution. Another close prior at compound, on a structural basis, is N naphthalenyl)carbonyl] glycine, [see Chem. Abstr., 61, 4333f (1964) for E. Cioranescu et al., Rev. Chim. Acad. Rep. Populaire Roumaine, 7(2), 755 (1962)]. The compound, which has been used as a chemical intermediate, is distinguished from the compounds of the present invention by being an amide and not a thioamide. The Nsaphthoylglycine derivatives of this invention are represented by formula I EMI3.1 wherein R1 is hydrogen, lower alkyl, lower alkenyl or phenylmethyl; R2 is hydrogen or lower alkyl; R3 is hydrogen, a lower alkoxy at position 6 of the naphthalene ring, or a substituent at position 4, 5 or 8 of the naphthalene ring, the substituent being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro, trihalomethyl and trihalomethylthio, and R4 and R5 each is hydrogen; or R3 and R4 each is a substituent at different positions selected from positions 3 to 7 of the naphthalene ring, the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, trihalomethyl, trihalomethylthio, (lower)alkoxy(lower)alkoxy, phenylmethoxy and phenylmethoxy substituted on the phenyl portion with a lower alkyl, lower alkoxy, halo or trihalomethyl, and R5 is hydrogen; or R3, R4 and R5 each is a substituent at different positions selected from positions 4, 5 and 6 of the naphthalene ring, the substituent being selected from the group consisting of lower alkoxy, halo and trihalomethyl; or a therapeutically acceptable salt with an organic or inorganic base of the compound of formula I wherein R 2 is hydrogen. A group of preferred derivatives is represented by the compounds of formula t wherein R1 is hydrogen, lower alkyl, 2-propenyl or phenylmethyl; R2 is hydrogen or lower alkyl; R3 is hydrogen, a lower alkoxy at position 6 of the naphthalene ring, or a substituent at positions 4, 5 or 8 of the naphthalene ring, the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro and trifluoromethyl, and R4 and R5 each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring, each substituent being at a different position of the ring, the pair of substituents being selected from the group of pairs consisting of 3-halo-4-lower alkoxy, 4,6-di(lower alkoxy), halo-6-lower alkyl, Shalo-6-lower alkoxy, 5,7-dihalo, 5-(trifluoromethyl)-6-lower alkoxy, 5-(trifluoromethylthio)-ss-lower alkoxy, 5-halo-6-(lower)alkoxy(lower)alkoxy, 5-halo-6-[3-(trifluoromethyl)phenylmethoxy] and 5-halo-6-(4-chlorophenylmethoxy), and -5 is hydrogen; or R3, R4 and R5 each is a substituent on the naphthalene ring, each of the three substituents being at different positions on the ring, the three substituents being selected from the group of Glower alkoxy-5-halo-6-lower alkoxy and 4,6-di(1ower aiicoxy)- 5-(trifluoromethyl); or a therapeutically acceptable salt with an organic or inorganic base of the compound of formula I wherein R2 is hydrogen. Another preferred group of the compounds is represented by the compounds of formula I wherein R1 is hydrogen, lower alkyl or phenylmethyl; R2 is hydrogen or lower alkyl; R3 is 4-halo or 5-halo, and R4 and R5 each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring selected from the group of pairs consisting of 3-halo-4-lower alkoxy, 4,6-diflower alkoxy), 5-halo-6-lower alkyl, 5-halo-6-lower alkoxy, 5,7-dihalo, 5-(trifluoromethylp 8-lower alkoxy and 5-(trifluoromethylthio)-6-lower alkoxy, and R5 is hydrogen; or R3 is 4-lower alkoxy, R4 is 5 (trifluoromethyl) and R5 is 8-lower alkoxy; or a therapeutically acceptable salt with an organic or inorganic base of the compound of formula I wherein R2 is hydrogen. A most preferred group of the compounds is represented by the compounds of formula 1 wherein R1 is lower alkyl; R2 is hydrogen; R3 is 5-halo and R4 and R5 each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring selected from the group of pairs consisting of 3-halo-4- lower alkoxy, 5-halo-6-lower alkoxy, 5Atrifluoromethyl)-8-lower alkoxy and 5trifluoromethylthio)-6-lower alkoxy, and R5 is hydrogen; or R3 is 4-lower alkoxy, R4is 54trifluoromethyl) and R5 is 8-lower alkoxy; or a therapeutically acceptable salt thereof with an organic or inorganic base. The compounds of formula I can be prepared by a process described hereinafter. A method is provided for preventing or relieving diabetes mellitus associated complications in a diabetic mammal by administering to said mammal a prophylactic or alleviating amount of the compound of formula I or thera peutically acceptable salt thereof with an organic or inorganic base. The complications include neuropathy, nephropathy, retinopathy and cataracts. The compound of formula I, or a therapeutically acceptable salt thereof with an organic or inorganic base, when admixed with a pharmaceutically acceptable carrier, forms a pharmaceutical composition which can be used according to the preceding method. The compounds of this invention, represented by formula I, can exist in rotameric forms. More explicitly, mesomerism imparts a partial double bond character to the carbonnitrogen bond of the thioamide group. This partial double bond character leads to restricted rotation about the carbon nitrogen bond giving rise to cis and trans rotamers, the restricted rotation being augmented by the bulkiness of neighboring groups. bterconversion of the rotamers is possible and is dependent on the physical environment. As evidenced by its physical properties, the thermodynamically more stable rotamer exists exclusively in the crystalline state of the compound and is the predominant isomer present in equilabrated solutions. Furthermore, the more stable rotamer is the more pharmacologically active. The less stable rotamer can be separated from the more stable rotamer by high performance liquid chromatography or by thin layer chromatography. The rotameric forms are included within the scope of this invention. For brevity, the compounds of this invention, including their rotameric forms, are referred to herein as compounds of formula I. The term Nower alkyl as used herein means a straight chain alkyl radical containing from one to four carbon atoms or a branched chain alkyl radical containing three or four carbon atoms and includes methyl, ethyl, propyl, 1-metbylethyl, butyl, 2-methylpropyl and l,ldimethylethyl. Preferred lower alkyl radicals contain from one to three carbon atoms. The term 'lower alkenyl" as used herein means a straight chain alkenyl radical containing from two to six carbon atoms, or a branched chain alkenyl radical containing from four to six carbon atoms and includes, for example, ethenyl, 2-propenyl, 2- m ethy1-2-propenyl and 2-ethyl-3-butenyl. Preferred lower alkenyl radicals contain two to three carbon atoms. The term "lower alkoxy" as used herein means a straight chain alkoxy radical containing from one to six carbon atoms, preferably one to three carbon atoms, or a branched chain alkoxy radical containing three or four carbon atoms, and includes methoxy, ethoxy, 1-methylethoxy, butoxy and hexanoxy. The term "halo" as used herein means a halo radical and includes fluoro, chloro, bromo and dodo. The term "ar" as used mean an aromatic radical containing at least one benzene ring. The preferred aromatic radical is phenyl. The compounds of formula I wherein R2 is hydrogen form salts with suitable therapeutically acceptable inorganic and organic bases. These derived salts possess similar activity to their parent acid and are included within the scope of this invention. The acid is transformed in excellent yield into the corresponding therapeutically acceptable salt by neutralization of said acid with the appropriate inorganic or organic base. The salts are administered usually in the same manner as the parent acid compounds. Suitable inorganic bases to form these salts include, for example, the hydroxides, carbonates or bicarbonates of the therapeutically acceptable alkali metals or alkaline earth metals, for example, sodium, potassium, magnesium, calcium and the like. Suitable organic bases include the following amines: benzylamine; lower mono-, di- and trialkylamines, the alkyl radicals of which contain up to three carbon atoms, such as methylamine, dimethylamine, trimethylamine, ethylamine, diand triethylamine, methylethylamine, and the like; mono-, di- and trialkanolamines, the alkanol radicals of which contain up to three carbon atoms, for example, mono-, di- and triethanolamine; alkylene-diamines which contain up to six carbon atoms, such as hexamethylenediamine; cyclic saturated or ufi saturated bases containing up to six carbon atoms, such as pyrrolidine, piperidine, morpholine, piperazine and their N-alkyl and N-hydroxyalkyl derivatives, such as N-methyl-morpholine and N-(2-hydroxyethyl)-piperidine, as well as pyridine. Furthermore, there may be mentioned the corresponding quaternary salts, such as the tetraalkyl (for example tetramethyl), alkyl-alkanol (for example methyltriethanol and trimethyl-monoethanol) and cyclic ammonium salts, for example the N-rn ethylpyridinium, N-methyl-N42-hydroxyethyl)-morphollnium N,N-di methylm orpholi nium, N-methyl-N-(2-hydroxyethyl)-morpholinium, N, N-dim ethyl- piperidinium salts, which are characterized by having good watebsolubility. In principle, however, there can be used all the ammonium salts which are physiologically compatible. The transformations to the salts can be carried out by a variety of methods known in the art. For example, in the case of the inorganic salts, it is preferred to dissolve the acid of formula I in water containing at least one equivalent amount of a hydroxide, carbonate, or bicarbonate corresponding to the inorganic salt desired. Advantageously, the reaction is performed in a water-miscible, inert organic solvent, for example, methanol, ethanol, dioxane, and the like in the presence of water. For example, such use of sodium hydroxide, sodium carbonate or sodium bicarbonate gives a solution of the sodium salt. Evaporation of the solution or addition of a water-miscible solvent of a more moderate polarity, for example, a lower alkanol, for instance, butanol, or a lower alkanone, for instance, ethyl methyl ketone, gives the solid inorganic salt if that form is desired. To produce an amine salt, the acidic compound of formula I may be solved in a suitable solvent of either moderate or low polarity, for example, ethanol, methanol, ethyl acetate, diethyl ether and benzene. At least an equivalent amount of the amine corresponding to the desired cation is then added to that solution. If the resulting salt does not precipitate, it can usually be obtained in solid form by addition of a miscible diluent of lower polarity, for example, benzene or petroleum ether, or by evaporation. If the amine is relatively volatile, any excess can easily be removed by evaporation. It is preferred to use substantially equivalent amounts of the less volatile amines. Salts wherein the cation is quaternary ammonium may be produced by mixing the acid of formula I with an equivalent amount of the corresponding quaternary ammonium hydroxide in water solution, followed by evaporation of the water. The compounds of formula I and their addition salts with pharmaceutically acceptable organic or inorganic bases may be administered to mammals, for example, man, cattle or rabbits, either alone or in dosage forms,e.g, capsules or tablets, combined with pharmacologically acceptable excipients, see below. Advantageously the compounds of this invention may be given orally. However, the method of administering the present active ingredients of this invention is not to be construed as limited to a particular mode of administration. For example, the compounds may be administered topically directly to the eye In the form of drops of sterile, buffered ophthalmic solutions, preferably of pH 7.2 - 7.6. Also, they may be administered orally in solid form containing such excipients as starch, milk sugar, certain types of clay and so forth. They may also be administered orally in the form of solutions or they may be injected parenterally. For parenteral administration they may be used in the form of a sterile solution, preferably of pE4 7*2 - 7.6, containing a pharmaceutically acceptable buffer. The dosage of the present therapeutIc agents will vary with the form of administration and the particular compound chosen. Furthermore, it will vary with the particular host under treatment. Generally, treatment is initiated with small dosages substantially less than the optimal dose of the compound. Thereafter, the dosage is increased by small increments until efficacy is obtained. In general, the compounds of this invention are most desirably administered at a concentration level that will generally afford effective results without causing any harmful or deleterious side effects. For topical administration a 0.05 - 0.2% solution may be administered dropwise to the eye. The frequency of instillation varies with the subject under treatment from a drop every two or three days to once daily. For oral or parenteral administration a preferred level of dosage ranges from about 0.1 mg to about 200 mg per kilo of body weight per day, although aforementioned variations will occur. However, a dosage level that is in the range of from about 0.5 rung to about 30 mgperkilo of body weight per day is most satisfactory. Unit dosage forms such as capsules, tablets, pills and the like may contain from about 5.0 mg to about 250 mg of the active ingredients of this invention, preferably with a significant quantity of a pharmaceutical carrier. Thus, for oral administration, capsules can contain from between about 5.0 mg to about 250 mg of the active ingredients of this invention with or without a pharmaceutical diluent. Tablets, either effervescent or noneff ervescent, can contain between about 5.0 to 250 mg of the active ingredients of this invention together with conventional pharmaceutical carriers. Thus, tablets which may be coated and either effervescent or noneffervescent may be prepared according to the known art. Inert diluents or carriers, for example, magnesium carbonate or lactose, can be used together with conventional disintegrating agents for example, magnesium stearate. Syrups or elixirs suitable for oral administration can be prepared from water soluble salts, for example, sodium Ng15-(trifluoromethylp6-methoxy- Iaphthalenyl] thioxomethyli -N-methylglycinate, and may advantageously contain glycerol and ethyl alcohol as solvents or preservatives. The compound of formula I, or a therapeutically acceptable salt thereof, also can be used in combination with insulin or oral hypoglycemic agents to produce a beneficial effect in the treatment of diabetes mellitus. In this instance, commercially available insulin preparations or oral hypoglycemic agents, exemplified by acetohexamide, chlorpropamide, tolazamide, tolbutamide and phenformin, are suitable. The compound of formula I, or a therapeutically acceptable salt thereof, can be administered sequentially or simultaneously with insulin or the oral hypoglycemic agent. Suitable methods of administration, compositions and doses of the insulin preparation or oral hypoglycemic agent are described in medical textbooks; for instance, "Physicians' Desk Reference", 34 ed., Medical Economics Co., Oradell, N.J., U.S.A., 1980. When used in combination, the compound of formula I, or its therapeutically acceptable salt, is administered as described previously. The compound of formula I, or its therapeutically acceptable salt, can be administered with the oral hypoglycemic agent in the form of a pharmaceutical composition comprising effective amounts of each agent. The aldose reductase inhibiting effects of the compounds of formula I and their pharmaceutically acceptable salts with organic or inorganic bases can be demonstrated by employing an in vitro testing procedure similar to that described by S. Hayman and J. H. Kinoshita, J. Biol. Chem., 240, 877 (1965). In the present case the procedure of Hayman and Kinoshita is modified in that the final chroma tography step is omitted in the preparation of the enzyme from bovine lens. The following results were obtained when the foregoing listed compounds of formula I were evaluated in the above in vitro test. EMI10.1 <tb> <SEP> % <SEP> Inhibition <SEP> at <tb> <SEP> Example <SEP> Different <SEP> Molar <tb> <SEP> In <SEP> Which <SEP> Concentrations <tb> Compound <SEP> of <SEP> Formula <SEP> I <SEP> (R5=H) <SEP> Compound <SEP> (in <SEP> vitro) <tb> RÚ <SEP> Rê <SEP> R <SEP> R4 <SEP> Is <SEP> Prepared <SEP> 10-5 <SEP> 10-6 <SEP> 10-7 <tb> CH3 <SEP> CH3 <SEP> 5-Br <SEP> H <SEP> 3 <SEP> 8 <tb> CH3 <SEP> CH3 <SEP> 5-CF3 <SEP> 6-CH3O <SEP> 23 <SEP> 9 <tb> CH3 <SEP> H <SEP> 5-Br <SEP> H <SEP> 32 <SEP> 93 <SEP> 87 <SEP> 47 <tb> H <SEP> H <SEP> 3-Cl <SEP> 4-CH3O <SEP> 32 <SEP> 61 <SEP> 16 <tb> CH3 <SEP> H <SEP> 4-Br <SEP> H <SEP> 33 <SEP> 91 <SEP> 77 <SEP> 32 <tb> CE3 <SEP> H <SEP> 8-Br <SEP> H <SEP> 34 <SEP> 88 <SEP> 75 <SEP> 24 <tb> CH3 <SEP> H <SEP> 5-CH3O <SEP> H <SEP> 35 <SEP> 83 <SEP> 64 <SEP> 17 <tb> CH3 <SEP> H <SEP> 5-CH3 <SEP> H <SEP> 36 <SEP> 89 <SEP> 74 <SEP> 26 <tb> CH3 <SEP> H <SEP> 5-Br <SEP> 6-CH3(CH2)4O <SEP> 37 <SEP> 93 <SEP> 91 <SEP> 55 <tb> CH3 <SEP> H <SEP> 5-CN <SEP> H <SEP> 38 <SEP> 89 <SEP> 79 <SEP> 32 <tb> CH3 <SEP> H <SEP> 5-NO2 <SEP> H <SEP> 39 <SEP> 91 <SEP> 83 <SEP> 43 <tb> CH3 <SEP> H <SEP> 5-C1 <SEP> H <SEP> 40 <SEP> - <SEP> 91 <SEP> 83 <SEP> 40 <tb> CH3 <SEP> H <SEP> 5-Br <SEP> 6-CH3O <SEP> 41 <SEP> 99 <SEP> 91 <SEP> 72 <tb> CH3 <SEP> H <SEP> 5-Br <SEP> 6-CH3 <SEP> 42 <SEP> 92 <SEP> 88 <SEP> 55 <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> 43 <SEP> 85 <SEP> 51 <SEP> 13 <tb> CH3 <SEP> H <SEP> 4-Cl <SEP> H <SEP> 44 <SEP> 88 <SEP> 73 <SEP> 25 <tb> CH3 <SEP> H <SEP> 3-Cl <SEP> 4-CH3O <SEP> 45 <SEP> 85 <SEP> 78 <SEP> 33 <tb> CH3 <SEP> H <SEP> 5-Cl <SEP> 7-C1 <SEP> 46 <SEP> 88 <SEP> 75 <SEP> 29 <tb> CH3 <SEP> H <SEP> 5-1 <SEP> 6-CH3O <SEP> 47 <SEP> 98 <SEP> 95 <SEP> 72 <tb> CH3 <SEP> H <SEP> 5-CN <SEP> 6-CH3O <SEP> 48 <SEP> 98 <SEP> 93 <SEP> 74 <tb> CH3 <SEP> H <SEP> 5-Br <SEP> 6-CH3O(CH2)3O <SEP> 49 <SEP> 92 <SEP> 87 <SEP> 38 <tb> CH3 <SEP> H <SEP> 5-CH2=C(CH3) <SEP> H <SEP> 50 <SEP> 92 <SEP> 74 <SEP> 19 <tb> CH3 <SEP> H <SEP> 5-(CH3)2CH <SEP> H <SEP> 51 <SEP> 91 <SEP> 72 <SEP> 21 <tb> CH3 <SEP> H <SEP> 5-CF3 <SEP> 6-CH3O <SEP> 52 <SEP> 98 <SEP> 94 <SEP> 65 <tb> CH3 <SEP> H <SEP> 5-Br <SEP> 6-[(3-CF3-C6H4)CH2O] <SEP> 53 <SEP> 86 <SEP> 37 <SEP> 11 <tb> CH3 <SEP> H <SEP> 5-Br <SEP> 6-[(4-Cl-C6H4)CH2O] <SEP> 53a <SEP> 88 <SEP> 44 <SEP> 4 <tb> CH3 <SEP> H <SEP> 5-CF3 <SEP> H <SEP> 53b <SEP> 93 <SEP> 84 <SEP> 33 <tb> H <SEP> H <SEP> 5-Br <SEP> H <SEP> 54 <SEP> 54 <SEP> 14 <tb> n-C3H7 <SEP> H <SEP> 5-Br <SEP> H <SEP> 55 <SEP> 91 <SEP> 70 <SEP> 19 <tb> EMI11.1 <SEP> - <SEP> - <SEP> <SEP> [7] <SEP> Inhibition <SEP> at <tb> <SEP> Example <SEP> Different <SEP> Molar <tb> <SEP> In <SEP> Which <SEP> Concentrations <tb> ula <SEP> I <SEP> (R@ <SEP> = <SEP> H) <SEP> Compound <SEP> (in <SEP> vitro) <tb> R1 <SEP> R <SEP> R2 <SEP> R@ <SEP> R@ <SEP> Is <SEP> Prepared <SEP> 10 <SEP> 5 <SEP> 10 <SEP> 610 <SEP> <tb> CH2=CH-CH2 <SEP> H <SEP> 5-Br <SEP> H <SEP> 56 <SEP> 92 <SEP> 77 <SEP> 27 <tb> C2H5 <SEP> H <SEP> 5-Br <SEP> H <SEP> 57 <SEP> 85 <SEP> 72 <SEP> 24 <tb> n C4Hg <SEP> H <SEP> 5-Br <SEP> H <SEP> 58 <SEP> 86 <SEP> 65 <SEP> 19 <tb> CH2C6H5 <SEP> H <SEP> 5-Br <SEP> H <SEP> 59 <SEP> 86 <SEP> 69 <SEP> 20 <tb> CH3 <SEP> H <SEP> 5-CF3S <SEP> <SEP> 6CH30 <SEP> 65 <SEP> 96 <SEP> 94 <SEP> 73 <tb> The aldose reductase inhibiting property of the compounds of this invention and the utilization of the compounds in preventing, diminishing and alleviating diabetic complications are demonstrable in experiments using galactosemic rats, see Dvornik et al., cited above. Such experiments are exemplified hereinbelow after the listing of the following general comments pertaining to these experiments: (a) Four or more groups of six male rats, 50-70 g, Sprague-Dawley strain, were used. The first group, the control group, was fed a mixture of laboratory chow (rodent laboratory chow, Purina) and glucose at 20% (w/w 96) concentration. The untreated galactosemic group was fed a similar diet in which galactose is substituted for glucose. The third group was fed a diet prepared by mixing a given amount of the test compound with the galactose containing diet. The concentration of galactose in the diet of the treated groups was the same as that for the untreated galactosemic group. (b) Afte four days, the animals were Idlled by decapitation. The eyeballs were removed and punctured with a razor blade; the freed lenses were rolled gently on filter paper and weighed. The sciatic nerves were dissected as completely es possible and weighed. Both tissues were frqzen and can be kept up to two weeks before being analyzed for dulcitol. (c) The polyol determination was performed by a modification of the procedure of M. Kraml and L. Cosyns, Clin. Biochem., 2, 373 (1969). Only two minor reagent changes were made: (a) The rinsing mixture was an aqueous 5% (w/v) trichloroacetic acid solution and (b) the stock solution was prepared by dissolving 25 mg of dulcitol in 100 ml of an aqueous trichloroacetic acid solution.[N.B.: For each experiment the average value found in the tissue from rats fed the glucose diet was subtracted from the individual values found in the corresponding rat tissue to obtain the amount of polyol accumulated.] The following tabulated results show that the compounds of this invention diminish the accumulation of dulcitol in the lenses and sciatic nerves of rats fed galactose. The figures under L and N represent the percentage decrease of dulcitol accumulation in the tissues of the lens and sciatic nerve, respectively, for treated rats as compared to untreated rats. Compound of Formula I Dose L N R1 R2 R3 R4 R5 mg/kg/day CH3 H 5-Br H H 189 24 79 121 20 70 62 14 53 CH3 H 5-Cl H H 156 34 70 CH3 H 5-Br 6-CH3O H 162 34 58 - 78 29 - 58 15 - 32 CH3 H 3-C1 4-CH3O H 163 15 - 25 - 27 CH3 H 5-Cl 7-Cl H 52 29 45 CH3 H 5-CF3 6-CH30 H 26 15 94 CH3 CH3 5-CF3 6-CH3O H 11 10 44 CH3 H 5-CF3 H H 11 2 36 CH3 H 6-CH30 H H 162 - 32 CH3 H 4-CH3O 5-CF3 6-CH3O 144 33 85 25 - 48 CH3 H 5-CF3S 6{:H30 H 20.0 20 96 9.1 - 55 4.4 - 29 A process for the preparation of the compounds of formula I is illustrated by the following scheme wherein RÚ, R , R4 and R5 are as defined hereinbefore and COOR is an ester group which may be, for example, a lower alkyl or an ar(lower)alkyl ester; i.e., R is lower alkyl or ar(lower)alkyl. EMI13.1 More specifically, a process for preparing the compounds of formula I comprises: (a) reacting an amidoester of formula U wherein R1, R3, R4 and R5 are as defined herein and R is lower alkyl or ar(lower)alkyl with phosphorus pentasulfide to give the corresponding thioxoester of formula m wherein R1, R3, R4, 5 and R are as defined herein; or (b) hydrolyzing the thioxoester of formula m wherein Rl, R3, R4, R5 and R are as defined herein to obtain the corresponding compound of formula I wherein RÚ,R , R4 and R5 are as defined herein and R2 is hydrogen; or (c) hydrolyzing the amidoester of formula II wherein R1, R3, R4, R5 and R are as defined herein to obtain the corresponding amidoacid of formula IV wherein RÚ, R3, R4 and R5 are as defined herein, and reaeting the last-named compound with phosphorus pentasulfide to obtain the corresponding compound of formula I wherein R1, R3, R4 and R5 are as defined herein and R is hydrogen. Referring to the above section (a) of the last paragraph, the thioxo ester of formula m includes those corresponding compounds of formula I wherein R is lower alkyl, when R of the compound of formula m is lower alkyl. For clarity and convenience in the following discussion of the process, these latter compounds of formula I are included in the discussion and preparation of the compounds of formula III Still more specifically, the starting material of formula II can be prepared by coupling a naphthalenecarboxylic acid of formula V wherein R3, R4 and R5 are as defined herein with an aminoacid ester of formula VI wherein R1 and R are as defined herein. EMI14.1 The compounds of formula V and VI are known or can be prepared by known methods. For example, see nElsevier's Encyclopaedia of Organic Chem iStry," F. Radt, Ed., Series m, Vol. 12B, Elsevier Publishing Co., Amsterdam, 1953, pp 3965-4473. The preparation of a number of the naphthalenecarboxylic acids is illustrated by examples 1, la to 1k and 61 to 63, described hereinafter. The coupling of the naphthalenecarboxylic acid V and the amino acid ester VI is done preferably by the "carboxyl activation" coupling procedure. Descriptions of carboxyl-activating groups are found in general textbooks of peptide chemistry; for example K.D. Kopple, "Peptides and Amino Acids", W.A. Benjamin, Inc., New York, 1966, pp. 45-51, and E. Schr5der and K. Lubke, "The Peptides7 Vol. 1, Academic Press, New York, 1965, pp. 77-128. Examples of the activated form of the terminal carboxyl are the acid chloride, acid bromide, anhydride, azide, activated ester, or O-acyl urea obtained from a dialkylcarbodiimide. Preferred activated forms of the carboxyl are the acid chloride or the l-benzotriazolyl, 2,4,5-trichlorophenyl or succinimido activated esters. Returning to the flow diagram again, the amidoester of formula II may be reacted, for example, under anhydrous conditions with about two to five molar equivalents of phosphorus pentasulfide in an inert solvent, e.g. xylene or toluene, to obtain the correspondiz4; thioxoester of formula 11%. This reaction is performed conveniently at temperatures ranging from 80 to about 1500C and at times ranging from 20 minutes to four hours. Preferably, the reaction is performed in the presence of an organic base for instance,N-ethyl morpholine,triethylamine or pyridine. Thereafter, the thioxoester of formula III may be hydrolysed with a hydrolysing agent to give the corresponding product of formula I in which R2 is hydrogen. Generally speaking, this conversion is most conveniently performed by employing a base as the hydrolysing agent. The hydrolysis may be performed in the presence of sufficient water,followed by acidification of the reaction mixture, to yield the desired acid. However, it should be understood that the manner of hydrolysis for the process of this invention is not intended to be limited to basic hydrolysis since hydrolysis under acidic conditions and other variations, for example, treatment with lithium iodide in collidine (see L ieser and M Sieser,"Reagents for Organic Synthesis",John Wiley and Sons,Inc.,New York, 1969,pp 615 617),also are applicable. Hydrolysis under acidic conditions is preferred when the ester is a tert butyl ester. for basis hydrolysis, a preferred embodiment involves subjecting the ester to the action of a strong base,for example, sodium or potassium hy droxide,in the presence of sufficient water to effect hydrolysis of the ester. The hydrolysis may be performed using a suitable solvent,for example , me thenol ethanol or 2-methoxyethanol. The reaction mixture may be maintained at a temperature of from about 250 to 1000C or at the reflux temperature of the solvent employed until hydrolysis occurs. Usually ten minutes to six hours is sufficient for this hydrolysis. The reaction mixture is then rendered acidic with an acid,for example, acetic acid,hydrochloric acid or sulphuric acid to release the free acid. Alternatively,the amidoester of formula II can be hydrolysed under the same conditions as described hereinbefore to give the corresponding amido acid of formula IV wherein RÚ ,R ,R4 and R5 are as defined herein. The latter compound, when reacted with phosphorus pentasulfide in the manner described hereinbefore, then gives the corresponding compound of formula I herein RÚ ,R3 ,R4 and R5 are as defined herein and R2 is hydrogen. Note that the standard first step of the work up of the pentasulfide reaction mixture requires that the reaction mixture be decomposed in water. This action causes any corresponding thioacid,present in the reaction mixture as a result of the carboy group reacting with phosphorus pentasulfide, to be converted to the desired carboxylic acid. The amidoacid of formula IV also can be prepared by a previously reported process involving the reaction of the appropriate naphthalenecarboxylic acid chloride with the appropriate aminoacid corresponding to the aminoacid ester of formula VI in the presence of a base (proton acceptor). This process has been used to prepare N-[(l-naphthalenyl)carbonyl] glycine, see Chem. Abstr., 61, 4333 f (1964) for E. Cioranescu, et al., Rev. Chim., Acad. Rep. Populaire Roumaine, 7(2), 755 (1962). However, this process for preparing N-[(1-naph- thalenyl)carbonyl] glycine is generally inferior, based on yields, to the described process above. An interesting aspect of this invention is that certain amidoesters of formula II and certain amidoacids oS formula IY having the following formula EMI16.1 wherein R1 is lower alkyl, lower alkenyl or phenylmethyl; R3 is a substituent at position 4, 5 or 8 of the naphthalene ring, the substituent being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro and trihalo methyl, and R4 and R5 each is hydrogen; or R3 and R4 each is a substituent at different positions of the naphthalene ring, the positions selected from positions 3 to 7 and the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, trihalomethyl, trihalomethylthio, (lower)alkoxy(lower)- alkoxy, phenylmethoxy and phenylmethoxy substituted on the phenyl portion with a lower alkyl, lower alkoxy, halo or trihalomethyl and R5 is hydrogen; or R3, R4 and R5 each is a substituent at different positions selected from positions 4,5-and 6 of the naphthalene ring, the substituent being selected from the group consisting of lower alkoxy, halo and trihalomethyl; and.R is hydrogen or lower alkyl; or a therapeutically acceptable salt thereof with an organic or inorganic base, also have aldose reductase inhibiting effects. For example, in the above noted in vitro test, the following results were obtained for the amidoacids, de scribed in example 60: N-[(5-bromo-1-naphthalenyl)carbonyl]-N-methylglycine (10-5, 64%; 10-6, 21%); and N-[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]carbonyl]-N-methylglycine (10-5, 94; 10-6, 93%; 10 7, 60%). Accordingly, the latter amidoesters, amidoacids and the therapeutically acceptable salts with organic or inorganic bases, of the amidoacids are included within the scope of this invention. The following examples illustrate further this invention. EXAMPLE 1 5-(l-Methylethenyl)-l-naphthalenecarboxylic Acid (V, R = 5-CH2 = C(CH3) and R4 and R5 = H) In a nitrogen atmosphere, a solution of l-bromo-5-(l-methylethenyl)- naphthalene 4.21 g, described by W.F. Short and H. Wang, J. Chem. Soc., 991 (1950) in diethyl ether (140 ml) was added dropwise to a mixture of ethyl magnesium bromide (prepared from 2.94 g of magnesium and 4.29 ml of ethyl bromide) in diethyl ether (30 ml) at 0 C. The mixture was stirred at 20 C for 18 hr and then heated at reflux for 1 hr. The cooled solution was poured onto an excess of solid carbon dioxide. The mixture was dissolved in diethyl ether. The resulting solution was washed with a 2N aqueous solution of H2S04, brine and 10% aqueous NaHCO3(4x). The basic washes were combined and made acidic (pH3) with 6N aqueous HC1. The resulting solid was collected, washed with water and dried to give 9.7 g of the title compound; mp 138-1400 C; NMR(CDC13) 6 2.15 (s, 3H), 5.0 & 5.38 (2s, 2H), 8.0 (m, 6H), 10.75 (s,lH). EXAMPLE la 5-(1-Methylethyl)-1-naphthalenecarboxylic Acid (V, R3 = 5-(CH3)2CH and R4 and R5 = H) 5-(1-Methylethenyl)-1-naphthalenecarboxylic acid (4.36 g, described in Example 1), dissolved in ethanol (150 ml), was hydrogenated using 5% palladium on charcoal as catalyst at 200 C. Absorption of hydrogen was complete after 3 hr. The catalyst was removed by filtration. The filtrate was evaporated to give the title compound; mp 148-1504 C; NMR(CDCl3) 6 1.4 (d, J = 7Hz, 6H), 3.75 (septuplet, J = 7Hz. 1H), 8.0 (m. 6H). 10.1 (s. 1H). EXAMPLE lb 5-Bromo-6-methoxy-1-naphthalenecarboxylic Acid (V, R3 = 5-Br, R4 = 6-CH3O and R5 = H) A solution of bromine (2.49 ml, 45 mmoles) in glacial acetic acid (50 ml) was added dropwise to a stirred solution of 6-methyoxy-1-naphthalene- carboxylic acid 18.9 g, 44 mmoles, described by C.C. Price, et al., J. Am. Chem. Soc., 69, 2261(1947)] in glacial acetic acid (300 ml), cooled in an ice bath. The resulting precipitate was collected and washed with acetic acid and then water. Crystallization of collected precipitate from' glacial acetic acid gave the title compound; mp 262-264 C; NMR(DMSO-d6) 6 3.96 (s, 3H), 7.5-7.8 (m, 3H), 7.95 (d, 1H), 8.25 (d, 1H), 8.82 (d, IH). EXAMPLE lc 5-Bromo-6-methyl-1-naphthalenecarboxylic Acid (V, R3 = 5-Br, R4 = 6-CH3 and R5 = H) By following the procedure of Example Ib, but replacing 6-methoxy l-naphthalenecarboxylic acid with an equivalent amount of 6-methyl-l-naphth- alenecarboxylic acid, described by C.C. Price et al., J. Am. Chem. Soc., 63, 1857 (1941), the title compound; mp 253-255 C After crystallization from ethanolmethanol (3:1)], NMR (DMSO-d6) 6 2.6 (s, 3H), 8*0 (m, 5H), 10.5 (broad, 1H), was obtained EXAMPLE id 3-Chloro-4-methoxy-1-naphthalenecarboxylic Acid (V, R = 3-Cl, R4 = 4-CH3O and R5 = H) 3-Chloro-4-methoxy-l-naphthalenecarboxaldehyde [15.5 g, 70.2 mmoles, described by AJ. Ablewhite and K.R.H. Wooldridge, J. Chem. Soc. (C), 2488 (1967)] was added to a suspension of silver oxide in 10% sodium hydroxide (16.9 g of sodium hydroxide in 170 ml of water) and dioxane (100 ml). The mixture was stirred and heated at 800 C for 7 hr. The precipitate was removed by filtration through diatomaceous earth (sold under the trademark Celite). The clear filtrate was evaporated to dryness. The residue was dissolved in water. The solution was acidified and the resulting precipitate was separated by filtration. The precipitate was dissolved in ethyl acetate. The resulting solution was extracted with saturated sodium bicarbonate solution. The combined aqueous extracts were acidified. The resulting precipitate was separated by filtration and recry stallized from ethanol-water to give the title compound; mp 187-189 C; NMR (DMSO-d6) # 4.0 (s, 3H), 8.15 (m, 5H), 13.3 (broad lH); IR (Nujol*) 2900, 1700, 1260, 1160 cm-Ú; UV#max (EtOH) 303 (#7,400), 231 (56,300); Anal. Calcd: C, 60.90% H, 3.83% Found: C, 60.71% H, 3.87%. *Nujol is a trademark for a brand of white mineral oil EXAMPLE le 5,7-Dihloro-1-naphthalenecarboxylic Acid (V, R = 5-Cl, R4 = 7-Cl and R5 = H) Sulfuryl chloride (36.8 g, 273 mmoles) was added dropwise to a stirred suspension of benzfc,dl indole-2(lH)-one (20 g, 119 mmoles) in glacial acetic acid (275 ml) at 20 to 220 C. The mixture was heated at reflux for L5 hr, cooled and filtered. The collected solid was washed with glacial acetic acid and recrystallized from toluene to afford 6,8-dichloro-benz[c,d] indole-2(1H)-one, mp 265 C, des- cribed by Y.T. Rozhinskii, Zhur. Org. Khim., 8, 2388 (1972). A mixture of the latter compound (14 g, 58.8 mmoles) in 2% aqueous sodium hydroxide was refluxed for 4 hr. The mixture was cooled, mixed with sodium nitrite (3.8 g, 55 mmoles) and added dropwise to a cooled (0-50 C) solution of concentrated sulfuric acid (45 ml) in water (180 ml). The diazonium salt was salted out by addition of sodium bromide, collected by filtration and while still wet (drying dangerous) was added to a solution of sodium hypophosphate (39.2 g of NaH2PO 2.H2O) in water (100 ml). The mixture was stirred at 20-220 C for 48 hr. The resulting solid was collected by filtration and suspended in saturated sodium bicarbonate (300 ml). The insoluble material was collected by filtration and resuspended in hot, saturated sodium bicarbonate (200 ml). The suspension was filtered and the filtrate was cooled. The resulting precipitate of the sodium salt of the product was collected by filtration. The free acid was prepared by suspending the sodium salt in water and rendering the suspension acidic. More product was obtained by acidification of filtrates of the sodium salt. The combined crops were recrystallized from ethanol to yield 5.8 g of the title compound; mp 253-254 C; NMR (DMSOwd6) 6 8.3 (m, 5H), 10.6 (broad, 1H), UV#max (EtOH) 333 nm ( 2,350), 298 (7,000), 230 (53,300). EXAMPLE If 5-Iodo-6-methoxy-1-naphthalenecarboxylic Acid (V, R3 = 5-I, R4 = 6-CH30 and R5 = H) Iodine (7.08 g) and iodic acid (2.78 g) were added to a stirred solution of 6-methoxy-l-naphthalenecarboxylic acid methyl ester n5 g, 69.4 mmoles, described by C.C. Price et al., J. Amer. Chem. Soc., 69, 2261 (1947)] in 80% acetic acid (110 ml) and 98% sulfuric acid (0.97 ml). The solution was heated at 500 C for 5 hr, cooled and poured into water (100 ml). After the addition of sodium bisulfite to destroy the unreacted iodine, the precipitate was collected, washed with water and recrystallized from ethanol to afford the corresponding methyl ester of the title compound; mp 98-99 0C; NMR (CDCl3) # 3.95 (s,3H), 4.00 (5, 3H), 8.00 (m, 5H). A mixture of the latter ester (7.1 g, 21 mmoles), 10% aqueous sodium hydroxide (35 ml) and methanol (19.5 ml) was heated at reflux for I hr. The solution was cooled ta ice bath temperature and made acidic with IN aqueous hydrochloride. The resulting precipitate was collected, washed with water and dried under reduced pressure over phosphorus pentoxide to give 7 g of the title compound; mp 259-261 C; NMR (DMSO-d8) # 4.0 (s,3H), 8.15 (m, 5H), 10.56 (broad, 1H). EXAMPLE 1g 5-Cyano-6-methoxy-1-naphthalenecarboxylic Acid (V, R = 5-CN, R4 = 6-CH3O and R5 = H) A solution of bromine (26.6 g, 0.167 mole) in glacial acetic acid (25 ml) was added dropwise to a cooled suspension of 6-methoxy-1-naphthalenecarboxylic acid methyl ester (30 g, 0.13 9 moles) in glacial acetic acid (2.75 ml). The pre cipitate was collected, washed with water and crystallized from ethanol to give 33.3 g of 5-bromo-6-methoxy-1-naphthalenecarboxylic acid methyl ester; mp ll90 C; NMR (CDCl3) a 3.97 (s, 3H), 4.03 (s, 3H), 7.35 (d, J = 9.25Hz, 1H), 7.4 (m, 1H), 8.05 (d, J = 6.75 Hz, 1H), 8.45 (d, J = 825 Hz, 1H), 8.9 (d, J = 9.25,1H). The latter ester (10.1 g, 34 mmoles) and (Cu2(CN)2H2O (3.4 g, 17 mmoles) in distilled dimethylformamide (75 ml) containing 15 drops of pyridine was heated at 180 C for 5 hr. The hot mixture was poured into a mixture of ice (50 g) and conc. NH4OH (50 ml). The resulting precipitate was collected, washed with water, dried and recrystallized from chloroform-ethyl acetate to afford 5.6 g of 5-cyano-6-methoxy-1-naphthalenecarboxylic acid methyl ester: mp 210-2110 C, NMR (CDCl3)# 3.95 (s, 3H), 4.15 (s, 3H). To a stirred solution of the latter ester (5.95 g, 24.66 mmoles) in 2-methoxyethanol (100 ml) at 20-22 C, 4N aqueous NaOH solution (12.3 ml) was added. The reaction mixture was stirred at 20-22 C for 60 hr, diluted with water, cooled to 0 C and rendered acidic with IN aqueous HCl. The precipitate was collected and dried to yield 5.6g of the title compound; mp > 2900 C; NMR (DMSO-d6) Ï 4.1 (s, 3H), 8.1 (m, 5H). EXAMPLE lh 5-(Trifluoromethyl)-6-m ethoxy-l-naphthalenecarboxylic Acid (V, R3 = 5-CF3, R4=6-CH3OandR5 = H) A mixture of 5-iodo-6-methoxy-1-naphthalenecarboxylic acid methyl ester (10.26 g, 30 mmoles, described in Example If), trifluoromethyl iodide (12 g, 61.2 mmoles), freshly prepared copper powder (5.7 g, prepared according to the procedure of R.Q. Brewster and T. Groening, "Organic Syntheses", Coll. VoL II, John Wiley and Sons, New York, N.Y., U.S.A., 1948, p. 445) and pyridine (45 ml) was charged into a stainless steel autoclave. The vessel was shaken and heated at 1200 C for 20 hr and cooled to room temperature. The mixture was diluted with diethyl ether-ethyl acetate The insoluble material was removed by filtration. The filtrate was washed with (1:1). aqueous HCl, water and dried (MgSO4). The solvent was removed under reduced pressure. The residue was crystallized from ethanol to give 6.4 g of 5-(trifluoromethyl)-6-methoxy-l-naphthalenecar boxylic acid methyl ester; mp 1N #79-80 C; NMR (CDC13) d 3*95 (s, 6H), 8.00 (m, SH). A mixture of the latter ester (6.3 g, 27 mmoles), IN aqueous NaOH solution (34.12 ml) and methanol (100 ml) was stirred at 20.220 C for 4 hr. The mixture was adjusted to pH 7 with IN aqueous HC1, methanol was removed from the mixture by distillation and the concentrated mixture was made acidic (pH 2) with IN aqueous HCl. The resulting precipitate was collected and dried to yield 6 g of the title compound; mp 218-2190C; NMR (DMSO-d8) 6 4.0 (s, 3H), 8.3 (m, 5H), 10.6 (broad, 1H). EXAMPLE li 5-Bromo-6-[3-(trifluoromethyl) phenylm ethoxy] -l-naphthalenecarboxylic Acid [V, R = 5-Br, R4 = 6-[(CF3-C6H4)-CH2O] and R5 = A mixture of 5-bromo-6-methoxy-l-naphthalenecarboxylic acid (33.35 g, 0.11 moles, described in example Ib) in glacial acetic acid (460 ml) and 47% aqueous HBr(417 ml) was heated at reflux for 9 hr. The resulting precipitate was collected, washed with water and dried over P205 under reduced pressure. The precipitate was recrystallized from ethanol-water to give 21.45 g of 5-bromo-6.hydroxy. 1-naphthalenecarboxylic acid; mp) 225 C; NMR (DMSO-d6) # 8.0 (m, 5H), 11.0 (broad, 1H), 12.6 (broad, 1H). The latter acid (L2 g, 4.5 mmoles) was suspended in dry dimethyl formamide (DMF, 25 ml). Sodium hydride (0.43 g, 9D mmoles, 50% mineral oil suspension) was added in small portions to the stirred suspension. Stirring was continued until the evolution of hydrogen ceased. A solution of 3-(trifluoromethyl)- phenylmethyl chloride (2.63 g, 13.5 mmoles) in dry DMF (5 ml) was added dropwise and the mixture was heated to 50.600 C for 1 hr. The solvent was evaporated under reduced pressure to dryness. The residue was triturated with water. The solid was separated from the water by filtration. The collected solid was washed with hexane to remove residual mineral oil and then recrystallized from ethanol water to give 1.7 g of 5-bromo-6(3-trifluoromethyl)phenylmethox -l-naphthalene- carboxylic acid, 3"trifluoromethyl ester; mp 114-115 C, rn (CHCl3) 1715 cm. A mixture of the latter ester (L7 g, 2.9 mmoles), methanol (20 ml) and IN aqueous NaOH (4 ml) was stirred for 24 hr at 20-22 C. Additional 1N aqueous NaOH was added and the mixture was stirred at 400 C for 3 hr. The solvent was evaporated. The residue was dissolved in water and the solution made acidic. The resulting precipitate was collected, washed with water, dried and recrystallized from ethanol to give 1.0 g of the title compound; mp 229-2300 C; NMR (DMSO-d6) # 5.5 (s, 2H), 8.1 (m, 9H), 10.5 (broad, 1H). 5-Bromo-6-(4-chlorophenylmethoxy)-1-naphthalenecarboxylic acid, NMR (DMSO-d6) a 5.4 (s,2H), 7.7 (m, 9H), 11.0 (broad, 1H), is obtained by follow ing the procedure of Example 11 but replacing 3-(trifluoromethyl)phenylmethyl chloride with an equivalent amount of 4-chlorophenylmethyl chloride. EXAMPLE li 5-(Trifluoromethyl)-l-naphthalenecarboxylic Acid (V, R3 = 5-CF3 and R4 and 5 R =H) A mixture of 5-iodo-l-naphthalenecarboxyli c acid methyl ester t8.8 g, 28 mmoles, described by C. Seer and R. School, Justus Leibigs Ann. Chem., 398, 82 (1913)], trifluoromethyl iodide (12 g, 612 mmoles), freshly prepared copper powder (5.7 g, prepared according to the procedure of R. Q. Brewster and T. Groening, "Organic Syntheses", Coll. Vol. II, John Wiley and Sons, New York, N.Y., U.S.A., 1948, p. 445) and pyridine (45 ml) was charged into a stainless steel autoclave. The vessel was shaken and heated at 130 C for 24 hr and cooled to room temperature. The mixture was filtered to remove insoluble material. The filtrate was washed with IN aqueous HCl, water and brine, dried (MgSO4) and concentrated to dryness. The residue was crystallized from methanol to give 4.3 g of 5-(trifluoromethyl)-l-naphthalenecarboxylic acid methyl ester, NMR (CDCl3) 6 4.0 (s, 3H), 8.0 (m, 6H). The ester (4.25 g, 16.72 mmoles) was suspended in methanol (100 ml). A 2N aqueous NaOH solution (16.72 ml, 2 equivalents) was added to the suspension. The mixture was stirred at 20-220C for 18 hr. The resulting clear solution was adjusted to pH 8 with 1N aqueous HCl and concentrated under reduced pressure. The concentrate was adjusted to pH 3 with IN aqueous HC1. The resulting precipitate was collected, washed with water and dried under reduced pressure to give the title compound; mp 206-208 C. EXAMPLE 2 N-[(5-Bromo-1-naphthalenyl) carbonyl]-N-methylglycine Methyl Ester (11, R1 and R = CH3,R = 5Br and R4 and R5 = H) Procedure A: A catalytic amount (5 drops) of dry DMF was added to a suspension of the starting material of formula V, 5-bromel-naphthalenecarboxylic acid Do g, 39.8 mmoles, described by W.B. Short and H. Wang, J. Chem. Soc., 990 (1950)3, in thionyl chloride (100ml). The suspension was heated cautiously to reflux (caution: a vigorous reaction can occur). The mixture was refluxed for 20 min. The mixture was evaporated to dryness. Toluene was added to the solid residue and the mixture was evaporated to dryness. The residue was dissolved in pyridine (100 ml). The solution was cooled in an ice bath. Dry N-methylglycine methyl ester hydrochloride (11.1g, 79.6 mmoles), a starting material of formula VI, was added portionwise to the cooled solution. The mixture was stirred for 2 hr at 200 C and then heated at reflux for 1 hr. The pyridine was removed by evaporation. Water was added to the oily residue. The mixture was extracted with ethyl acetate (3 x 150 ml). The combined extracts were washed with IN aqueous HC1 solution, a saturated solution of sodium bicarbonate and brine. After drying over MgS04, the extract was treated with charcoal, filtered and evaporated. The residue was crystallized from diethyl ether or ethanol to give the title compound; mp 91-920 C; NMR (CDC13) a 2.8 & 3.25 (2s, 3H), 3.6 & 3.85 (2s, 3H), 4.35 (broad, 2H), 7.75 (m, 6H); UV#max (EtOH) 321 nm ( ±775), 316 (1,110), 299 (6,660), 289 (9,250), 279 (7,400), 225 (66,600); Anal. Calcd: C, 53.59% H, 4.20% N; 4.17%; Found: C,'53.60% H, 4.27% N, 4.21%. Procedure B: A mixture of the starting material of formula V, 5-bromo-l-naphthalene- carboxylic acid (12.8 g, 52 mmoles), and l-hydroxybenzotriazole (HOBt, 7.0 g, 52 mmoles) in DMF (200 ml) was prepared. N,N'-dicyclohexylcarbodiimide (DCC, 10.6 g, 52 mmoles) in DMF (30 ml) was added to the mixture. The resulting mixture was stirred at 200 C for 1 hr and then cooled to 00 C. N-Methylglycine methyl ester hydrochloride (7.25 g, 52 mmoles) and then N-ethylmorpholine (6.7 ml, 52 mmoles) were added to the cooled mixture. The mixture was stirred for 30 min at 00 C and then for 18 hr at 200 C. Thereafter, the mixture was filtered and concentrated to dryness under reduced pressure. The residue was subjected to chromatography on 325 g of silica gel using ethyl acetatewhexane (1:1) as the eluant. The pure fractions were pooled to yield 10.5 g of product which was re- crystallized from ethyl acetate to give the title compound, identical to the product of procedure A of this example. EXAMPLE 3 N-[(5-Bromo-1-naphthalenyl)thioxomethyl]-N-methyiglycine Methyl Ester (I, RÚ and Rê = CH3, R3 = 5-Br and R4 and R5 H) To a stirred solution of N-[(5-bromo-1-naphthalenyl)carbonyl]-N-methyl- glycine methyl ester (35.5 g, 106 mmoles, described in Example 2) in dry pyridine (100 ml), phosphorus pentasulfide (44.5 g, 200 mmoles) was added portionwise. The mixture was stirred and refluxed for L5 hr and then poured into a liter of water at 50 to 80 C (caution: evolution of copious quantities of H2S). The mixture was allowed to cool to 20 to 220 C (room temperature), filtered and the filtrate was extracted with ethyl acetate. The extract was washed with IN aqueous HC1 solution, brine, a saturated solution of sodium carbonate and brine, dried (MgSO4), filtered and evaporated to dryness. The residue was recrystallized from ethanol water (4:1) to give the title compound; mp 85-86 C; NMR (CDCl3) 6 3.0 (s, 3H), 3.85 (s, 3H), 4.58 & 5.37 (2d, J = 17, 2H), 71-83 (m, 6H); Uflmax (EtOH) 281 nm (C 14,480), 218 (14,480). By following serially the procedures of Examples 2 and 3 and using the appropriate starting material of formula V instead of 5-bromo-l-naphthalene- carboxylic acid, other compounds of formula I in which R1 and R2 each is methyl are obtained Examples of the latter compounds are listed as products in Tables 1 and II together with the appropriate starting material of formula V used for their preparation. TABLE 1 STARTING MATERLAL PRODUCT:N-[(prefix listed OF FORMULA V (R5 = H) below-1-NAPHTHALENYL) THIOXOMETHYL]-N-METHYL- EXAMPLE R3 . R4 . GLYCINE METHYL ESTER 4 4-Br H 4-bromo; NMR (CDCl3)# 2.85 & 3.25 (2s, 3H), 3.6 & 3.85 (2s, 3H), 4.35 (m, 2H), 7.7 (m, 6H); IR (CHCl3) 1730, 1620 cm-Ú 5 8-Br H 8-bromo; 1R(CHCl3) 1730, 1480, 1380, 1080 cmA; NMR (CDCl3)# 3.0 (s, 3H), 3.8 (s, 3H), 3.65 (m, 2H), 7.5 (m, 8H) 6 5-CH3O H 5-methoxy; NMR (CDCl3)# 2.81 & 3.21 (2s, 3H), 3.58 & BR< 3.80 (2s, 3H), 3.97 (s, 3H), 4.37 (broad, 2H), 6.80 (d, 1H), 7.40 (m, 4H), 8.27 (m, 1E); IR (CHCl3) 1740, 1630, 1578 cm-Ú 7 5-Me H 5-methyl; NMR (CDCl3) 6 L68 (s, 3H), 3.05 (3H), 3.85 (3H), 3.75 de 4.9 (m, 2H), 7.6 (s, 6H) 8 5-Br 6-[CH3(CH2)4O] 5-bromo-6-pentyloxy; mp 80-83 C; NMR (CDCl3) # 0.9 (t, J = 7Hz, 3H), 1.1-2.0 (broad, 2H), 3.0 (s, 3H), 3.8 (s, 3H), 4.1 (m, 2H), 7.1-8.5 (broad, SH) TABLE I (Continued) STARTING MATERIAL PRODUCT:N-[(prefix listed OF FORMULA V (R5=H) below-1-NAPHTHALENYL) THIOXOMETHYL]-N-METHYL EXAMPLE R R3 R4 GLYCINE METHYL ESTER 9 5-CN H 5-cyano; NMR (CDCl3) 6 3.00 (s, 3H), 3.85 (s, 3H), 4.45 & 5.45 (d, 2H), 7.18 (m, 6H) 9a 4-CN H 4-cyano; NMR (CDCl3) # 3.1 (s, 3H), 3.85 (s, 3H), 4.55 & 5.25 (2d, J = 17Hz, 2H), 7.08.4 (m, 6H) 10 5-NO2 H 5-nitro; mp 116-117 C 11 5-Cl H 5-chloro; mass spectrum, m/e: 307/309 (M+), 274/276 (M +-H, S), 248/246 (M+-COOMe) 12 5-Br 6-CH3O 5-bromo-6-methoxy; mp 115-117 C; NMR (CDCl3)# 3.00 (s, 3H), 3.84 (s, 3H), 3.98 (s, 3H) 13 5-Br 6-CH3 5-bromo-6-methyl; NMR (CDCl3) # 2.6 (s, 3H), 3.0 (s, 3H), 3.85 (s, 3H), 4.5 & 5.35 (d, J = 16.5 Hz, 2H), 7.7 (m, 5H) 14 H H #; IR (CHCl3) 1735 cm-1 # No prefix as compound is N-((1-naphthalenyl) thioxomethyl)-N methyiglycine methyl ester TABLE I (Continued) STARTING MATERIAL PRODUCTN-[(prefix listed OF FORMULA V (R5 = H) below-1-NAPHTHALENYL) 3 4 THIOXOMETHYL]-N-METHYL EXAMPLE R3 R4 GLYCINE METHYL ESTER 15 4-Cl H 4-chloro; mp 100-101 C; NMR (CDCl3) # 3.10 & 3.62 (2s, 3H); 3.90 & 3.70 (2s, 3H) 4.04, 4.55 & 5.37 (s, 2d, J = 16Hz, 2H), 7.2-8.4 (m, 6H); IR (CHCl3) 1740 cm-1; UY#max (EtOH) 283 nm ( #7,100), 219 (52,000); Anal. Calcd: C, 58.54% H, 4.58% N, 4.55%; Found: C, 58.58% H, 4.76% N, 4.58% 16 3-C1 4-CH30 3-chloro-4-methoxy; mp 85-86 C; NMR (CDC13) 6 3.05 (s, 3H), 3.85 (s, 311), 4.00 (s, 311), 4.58 & 5.3 (2d, J = 17Hz, 211), 7.6 (m, 511) 17 5-Cl 7-Cl 5,7-dichloro; m/e; 325/327/ 329 (M+), 266, 268, 270 (M+ COOCH3), 223/225/227 (Mt CH3-N-CH2-COOCH3) 18 5-I 6-CH3O 5-iodo-6-methoxy; mp 149 150 C; NMR (CDCl3) #3.00 (s, 311), 3.85 (s, 311), 3.95 (s, 311), 4.4 & 5.45 (d, 211), 7.6 (m, 5H) TABLE I (Continued) STARTING MATERLAL PRODUCT:N-[(prefix listed OF FORMULA V (R5 = H) below-1-NAPHTHALENYL) THIOXOMETHYL]-N-METHYL EXAMPLE R3 R GLYCINE METHYL ESTER 19 5-CN 5-CH3O 5-cyano-6-methxoy; mp 164-165 C; NMR (CDCl3)# 3.05 (s,3H), 3.90 (8, 3H), 4.07 (s,3H), 4035 & 5.55 (d, J =16.8Hz, 2H), 7.80 (m, 5H) With reference to Table 4 the starting materials of formula V are described by T.L Jacobs, et al., J. Org. Chem., 11,27 (1946) for example 4; by H.G. Rule et ale, Je Chem Soc., 168 (1934) for example 5; by A. Girardet and N. Lorusso, Helv. Chim. Acta., 49,471 (1966) for example 6; by M.J.S. Dewar and P.J. Grisdale, J. Am. Chem. Soc., 54, 3541(1962) for example 7; in example le for example 8; by M.J.S. Dewar and P.J. Grisdale, J. Am. Chem. Soc., 84, 3541 (1962) for examples 9, 9a, 10 and 11; in example 1b for example 12; in example ic for example 13; by H. Gilman et al., "Organic Syntheses", ColL Vol. U, John Wiley and Sons, New York, N.Y., U.S.A., 1948, p. 425 for example 14; by T.L. Jacobs et al, J. Org. Chem., 11 27 (1946) for example 15; in example ld for example 16; in example le for example 17; in example If fer example 18; and in example 1g for example 19. TABLE II STARTING MATERLAL PRODUCT:N-[[prefix listed OF FORMULA V (R = H) below-1-NAPHTHALENYL]- THIOXOMETHYL]-N-METHYL EXAMPLE R3 R GLYCINE METHYL ESTER 20 5-Br 6-[CH3O(CH2)3O] 5-bromo-6-(3-methoxypro- poxy); NMR (CDCl3) a 2.1 (m, 4H), 3.35 (s, 6H), 3.55 (m, 4H), 4.25 (t, J = 6Hz, 211), 4.45 (t, 5 = 6Hz, 2H), 7.4 (m, 2H), 8.0 (d, J = 8Hz, 1H), 8.4 (d, J = 8Hz, 1H), 8.85 (d, J = 8Hz, 1H) 21 5-[CH2=C(CH3)] H 5-(1-methylethenyl); mp 93-950 C; NMR (CDCl3) #2.15 (s,3H), 3.05 (s, 3H), 3.85 (s, 311), 4.55 de 5.3 (2s, 211), 5.0 & 5.35 (2s, 211), 7.6 (m, 611) 22 5-[(CH3)2CH] H 5-(1-methylethyl); NMR (CDCl3) 6 1.35 (m, 611), 3.0 & 3.55 (2s, 3H), 3.65 & 3.85 (2s, 311), 4.95 (2H), 7.5 (m, 6H) 23 5-CF3 6-CH3O 5-(trifluoromethyl)-6-methoxy; mp 109-110 C; NMR (CDCl3)# 3.00 (s, 3H), 3.85 (s, 3H), 3.95 (s, 311), 4.35 & 5.45 (d, 2H), 7.7 (m, 511) 24 5-Br 6-[(3-CF3-C6H4)- 5-bromo-6-[3-(trifluoromethyl) CH2O] phenylmethoxy]; NMR (CDCl3) TABLE II (Continued) STARTING MATERLAL PRODUCT:N-[(prefix listed OF FORMULA V(R5 = H) below-1-NAPHTHALENYL] THIOXOMETHYL]-N-METHYL EXAMPLE R3 R GLYCINE METHYL ESTER 24 (Cont'd) a 3.00 (s, 3H), 3.85 (s, 3H), 4.4 & 5.4 (2d, J = 16.5Hz, 2H), 5.25 (s, 2H), 7.6 (m, 9H) 24a 5-Br 6-[(4-Cl-C6H4)- 5-bromo-6-(4-chlorophenyl CH2O] methoxy); NMR (CDCl3)# 3.00 (s, 3H), 3.85 (s, 3H), 4.40 de 5.40 (d, 2H), 5.2 (s, 2H), 7.5 m 9H) 24b 5-CF3 H 5-(trifluoromethyl); NMR (CDCl3) d 3.00 (s, 3H), 3.85 (s,3H), 4.5 de 5.4 (d, 2H), 7.2- 8.3 (m, 6H). With reference to Table II, the starting materials of formula V are described in example, herein, for example 20; in example 1 for example 21; in example la for example 22; in example Th for example 23; in example li for example 24 and example 24a; and in example lj for example 24b. By following serially the procedures of examples 2 and 3, but using the appropriate starting material of formula VI instead of N-methylglycine, other compounds of formula I in which R2 is lower alkyl, R3 is 5-bromo, R4 is hydrogen are obtained. Examples of the latter compounds are listed as products in Table rn together with the appropriate starting material of formula VI used for their preparation. TABLE m STARTLNG MATERIAL PRODUCT:N-[(5-BROMO-1 OF FORMULA VI NAPHTHALENYL)THIOXO METHYL]-suffix listed EXAMPLE RÚ R below 25 H CH3 glycine methyl ester; mp 126 1300 C; NMR (CDCl3) 6 3.8 (s, 3H), 4.6 (d, J = 7Hz, 2H), 7.15-8.15 (m, 6H) 26 n-C3H7 C2H5 N-propylglycine ethyl ester; NMR (CDC13) 6 0.65 (t, J = 7Hz, 3H), 1.4 (t, 3H), 1.45 (m, 2H), 3.2 (t, J = 7Hz, 2H), 4.3 (q, J = 7Hz, 2H), 4.35 (d, J = 17Hz, 1H), 5.3 (d, J=17Hz, 1H), 7,7 (m, 6H); IR (CHCl3) 1740 cm-Ú 27 CH2=CH-CH2 CH3 N-(2-propenyl)glycine methyl ester; mp 72-74 C 28 C2H5 CH3 N-ethylglycine methyl ester; NMR (CDCl3)# 1.10 (t, 3H), 3.35 (q, 2H), 3.85 (5, 3H), 4.40 de 5.25 (d, 2H), 7.6 (m, 6H 29 n-C4Hg C2H5 N-butylglycine ethyl ester; NMR (CDCl3) 6 0.65 (t, J = 5.5 Hz, 3H), 1.0 (m, 2H), 1.38 (t, 3H), 1.40 (m, 2H), 3.25 (m, TABLE tII @ (Continued) STARTING MATERIAL PRODUCT:N-[(5-BROMO-1 OF FORMULA VI NAPHTHALENYL)THIOXO METHYL]-suffix listed EXAMPLE R1 R below 29 (Cont'd) 2H), 4.25 & 5.30 (4 3 = 16Hz, 2H), 7.7 (m, 6H) 30 C6H5CH2 C2H5 N-(phenylmethyl)glycine sthyl ester; mp 141-142 C; NMR (CDCl3) # 1.85 (t, J=7Hz, 3H), 4,50 (m, 6H), 7.50 (m, 11H); IR(Nujol* ) 1743 cm-Ú EXAMPLE 3i By following serially the procedure of Examples 2 and 3, but using the appropriate starting material of formula V and the appropriate aminoacid ester of formula VI, still other compounds of formula I in which R2 is lower alkyl are obtained. For example, by using 3-chloro-4-methoxy-1-naphthealenecar- boxylic acid, described in Example 1d, as the starting material of formula V, and using glycine ethyl ester hydrochloride as the starting material of formula VI, N-[(3-chloro-4-methoxy-1-naphthalenyl)thioxomethyl] glycine ethyl ester; IR (CHCl3) 3420, 3340, 1740, 1665 cm-Ú; mp 217 C(dec.); NMR (DMSO-d6) # 3.96 (S, 3H), 4.42 (d, J = 6Hz, 2H), 7.40 (s, 1H), 7.65 (m, 2H), 8.18 (m, 2H); IR (Nujol *) 3150, 2900, 1720, 1140 cm-Ú; UV#max(EtOH) 277 nm (# 11,400), 224 (51,300); Anal Calcd: C, 54.28% H, 3.91% N, 4.52%; Found: C, 54.26% H, 4.06% N, 4.62% via N-[(3-chioro-4-methoxy-1-naphthalenyl)carbonyl] glycine ethyl ester; mp 140-141 C; NMR (CDCl3)3 1.3 (t, J=7Hz, 3H), 4.2 (m, 4H), 6.55 (broad, 1H), 7.55 (m, 3H), 8.2 (m, 2H), was obtained. EXAMPLE 32 N-[(5-Bromo-1-naphthalenyl)thioxomethyl]-N-methylglycine (I, RÚ = CH3, Rê, R4 and R5 = H and R = 5-Br) * Trademark (a) 1N aqueous NaOH solution (25 ml) was added to a suspension of N-[(5-bromo-1-naphthalenyl)thioxomethyl]-N-methylglycine methyl ester (7.3 g, 20.7 mmoles; described in Example 3) in methanol (75 ml). The mixture was stirred at 20 to 220 C for 2 1/2 hr, neutralized to pH 7 with aqueous HCl and concentrated under reduced pressure to remove methanol. The residual solution was rendered acidic (pH = 2) with the addition of aqueous HCl solution and extracted with ethyl acetate. The extract was dried (MgSO4) and evaporated to dryness. The residue was crystallized from ethyl acetate-hexane to give 5.3 g of the title compound; mp 1810 C; NMR (DMSO-d6) # 2.95 (s, 3H), .65 de 5.2 (2d, J = 16.8, 2H), 7.85 (m, 6H), UVÀmax (EtOH) 285 nm (# @ 12,300), 280 (12,400), 221(42,600); IR(Nujol *) 2900, 1720 cmA; Anal Calcd: C, 49.72% H, 3.58% N, 4.14%; Found: C, 49.63% H, 3.63% N, 4.18%. (b) In the same manner, but replacing N-I(5-bru,m o-l-naphthalenyl)thioxb methyll-N-methylglycine methyl ester with an equivalent amount of N-[(3-chloro- 4-methoxy-1-naphthalenyl)thioxomethyl] glycine ethyl ester, described in Example 31, N-[(3-chloro-4-methoxy-1-naphthalenyl)thioxomethyl] glycine [mp 2170 C(dec); NMR(DMSO-d6) 6 3.96 (s, 3H), 4.42 (d, J = ssHz, 2H), 7.40 (s,1H), 7.65 (m, 2H), 8.18 (m, 2H); IR (Nujol +) 3150, 2900, 1720, 1140 cm-Ú; UV#max (EtOH) 277 nm (#11,400), 224 (51,300); Anal Calcd: C, 54.28% H, 3.91% N, 4.52%; Found: C, 54.26% H, 4.08% N, 4.62%l was obtained. By following the procedure of Example 32, but replacing N-[(5-bromo- 1-naphthalenyl)thioxomethyl]-N-methylglycine methyl ester with an equivalent amount of another ester compound of formula I in which R2. is lower alkyl, or corresponding compounds in which R is ar(lower)alkyl, the corresponding compound of formula I in which R is hydrogen was obtained. Examples of the latter compounds are listed as products in Tables IV, V and VI together with a notation to the corresponding compound of formula I in which Rê is lower alkyl from which they are prepared. In each case the compound of formula I in which R2 is lower alkyl, the starting material, is noted by the example in which it was prepared. * Trademark TABLE IV PRODUCT:N-[(prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL) WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED ¯ GLYCINE 33 4 4-bromo; mp 168-1690 C, NMR(DMSO-d6) 6 3.0 (s, 3H), 4.65 & 5.15 (d, J = 16.5Hz, 2H), 7.7 (m, 6H); Anal Calcd: C, 49.71% H, 3.58% N, 4.14%; Found: C, 49.56% H, 3.42% N, 4.22% 34 5 8-bromo; mp 65-85 C; Anal Calcd: C, 49.72% H, 3.58% N, 4.14%; Found: C, 53.54% H, 4.05% N, 4.40% 35 6 5-methoxy; mp 120 C; NMR (DMSO-d6) 6 2.93 (s, 3H), 3.90 (s, 3H), 4.65 & 5.16 (2d, J =17Hz, 2H), 6.95 (2d, J1=7Hz, J2=3Hz, 1H), 7.35 (m, 4H), 8.11 (2d, J1=8Hz, J2=2Hz, 1H); IR(Nujol#) 2900, 1734, 1715 cm-1; UV#max EtOH) 281 nm (# 11,600), 233 (30,600); Anal Calcd: C, 62.27% H, 5.23% N, 4.84%; Found: C, 61.62% H, 5.95% N, 4.22% 36 7 5-methyl; mp 190-191 C, NMR (CDCl3)# 2.66 (s, 3H), * Trademark TABLE IV (Continued) PRODUCT:N-[(prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL) WHICH STARTING MATERIAL THIOXOMETHYL)-N-METHYL EXAMPLE WAS PREPARED GLYCINE 36 (Cont'd) 3.05 (s, 3H), 3.85 & 5.0 (m, 2H), 7.5 (m, 6H), 8.75 (broad, 1H); IR(CHCl3) 3000, 1755 1720 cm-1; UV#max (EtOH) 282 nm ( ±15,280), 226 (39,690), 218 (41,385); Anal Calcd: C, 65.90% H, 5.53% N, 5.12%; Found: C, 65.79% H, 5.57% N, 5.08% 37 8 5-bromo-6-pentyloxy; mp 211-217 C; NMR (DMSO-d6)# 0.9 (t, J = 6Hz, 3H), 1.6 (m, 2H), 2.9 (s, 3H), 4.2 (t, J = 6Hz, 2H), 3.95 & 5.15 (d, J = 15Hz, 2H), 7.1-8.55 (m, 5H); IR(Nujol #) 3000, 1650 cm-1 38 9 5-cyano; mp 190-200 C; NMR (DMSO-d6) #3.00 (s, 3H), 4.65 & 5.15 (d, J = 17Hz, 2H), 7.95 (m, 6H); IR(Nujol *) 3000, 2230, 1730 cmA; UV#max (EtOH) 313 nm (# 5,600), 271 (13,850), 249 (14,620), 222 (48,340); Anal Calcd: C, 63.36% H, * Trademark TABLE IV (Continued) PRODUCT:N[(prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL) WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED . GLYCINE 38(Cont'd) 4.34% N, 9.85%; Found: C, 62.01% H, 4.34% N, 9.36% 38a 9a 4-cyano; mp 192-193 C; NMR (DMSO-d6) #3.0 (s, 3H), 4.7 & 5.2 (d, J=17Hz, 2H), 7.8 (m, 6H), 10.05 (broad, 1H); IR (Nujol * ) 3180, 2230, 1745 (with inflection at 1755)cm-Ú 39 10 5-nitro; mp 142-1430 C; NMR (CDCl3) # 3.05 (s, 3H), 4.65 & 5.4 (d, 2H), 7.9 (m, 6H), 9.4 (broad, 1H); IR(Nujol *) 2900, 1715, 1530, 1345 cm-Ú; UV#max (EtOH) 332 nm (# 4,110) 269 (17,010); Anal Calcd: C, 55.26% H, 3.96% N, 9.20%; Found: C, 55.17% H, 3.86% N, 9.10% 40 11 5-chloro; mp 153-154 C; NMR(CDCl3)# 3.03 (s, 3H), 4.67 & 5.33 (d, J=17Hz, 2H), 7,50 (m, 4H), 7.90 (d, J = 8Hz, 1H), 8.25 (d,J=8,1H); IR(CHCl3) TABLE IV (Continued) PRODUCT:N-[(prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL) WHICH STARTING MATERIAL THIOXOMETHYL] -N-METHYL EXAMPLE WAS PREPARED GLYCINE 40 (Cont'd) 3000, 1720 cm-1; UV#max (EtOH) 280 nm (# 16,780), 212 (52,290); Anal Calcd: C, 57.23% H, 4.12% N, 4.77%; Found: C, 58.02% H, 4.28% N, 4.94% 41 12 5-bromo-6-methoxy; mp 166-168 C; NMR (CDCl3)# 3.02 (s, 3H), 4.06 (s, 3H), 4.61 & BR< 5.39 (d, J = 17Hz, 2H); IR (CHCl3) 3000, 1718 cm-1; UV#max (EtOH) 341 nm (4,350), 329 (4,015), 273 (13,150), 237 (51,260); Anal Calcd: C, 48.92% H, 3.83% N, 3.80%; Found: C, 49.11% H, 3.90% N, 3.91% 42 13 5-bromo,B-methyl; mp 190-192 C; NMR (CDCl3) # 2.6 (s, 3H), 3.05 (s, 3H), 4.56 & 5.3 (d, 2H), 7.6 (m, 5H); IR (CHCl3) 3000, 1720 cm-1; UV#max (EtOH) 280 nm (# 14,055), 223 (43,400); Anal Calcd: C, 51.14% H, 4.01% TABLE IV (Continued) PRODUCT:N-[(prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL) WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED GLYCINE 42 (Cont'd) N, 3.98%; Found: C, 51.21% H, 4.03% N, 4.00% 43 14 # ; mp 146-147 C; NMR (CDCl3) # 3.05 & 3.70 (2s, 3H), 4.07, 4.75 & 5.30 (s, 2d, J = 17Hz, 2H), 6.8-8.0 (m, 7H), 9.20 (broad, 1H); IR(CHCl3) 3000, 1720 (inflection at 1755) cm-1; UV#max (EtOH) 280 nm (# 14,415), 215 (53,450); Anal Calcd: C, 64.87% H, 5.05% N, 5.40%; Found: C, 64.89% H, 5.14% N, 5.51% 44 15 4-chloro; mp 165-166 C; NMR (CDCl3)# 3.05 & 3.70 (2s, 3H), 4.10 4.70 & 5.3 (s, 2d, J = 17Hz, 2H), 7.2-8.4 (m, 6H), 10.5 (s, 1H), IR(CHCl3) 3000, 1725 (with Inflection at 1765)cm-1; UV#max (EtOH) 283 nm (#13,500), 220 (49,600); Anal Calcd: C, 57.24% H, 4.12% N, 4.77%; Found: C, 57.56% H, 4.28% N, 4.84% * No prefix as compound is N-((1-naphthalenyl) thioxomethyl)-N- methylglycine TABLE IV (Continued) PRODUCT:N-[(prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL) WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED GLYCINE 45 16 3-chloro-4-methoxy; mp 138-139 C; NMR (DMSO-d6) # 3.0 (s, 3H), 3.45 (s, 3H), 4.6 & 5.15 (2d, J =16.8Hz, 2H), 7.3 (s, 1H), 7.8 (m, 4H); tR(Nujol* )2900, 1723 cmA; UV#max (EtOH) 329 nm 2,200), 282 (13,210), 224 (53,980); Anal Calcd: C, 55.64% H, 4.36% N, 4.33%; Found: C, 55.63% H, 4.48% N, 4.40% 48 17 5,7-dichloro; mp 174-175 C; NMR(DMSO-d6) #2.97 (3H), 4.57 & 5.27 (2d, J = 17Hz, 2H), 7.3-8.3 (m, 5H); IR(Nujol#) 3000, 1708 cm-1; UV#max (EtOH) 334 nm ( #3,050), 273 (15,810), 226 (63,800); Anal Calcd: C, 51.23% H, 3.38% N, 4.27%; Found: C, 51.44% H, 3.52% N, 4.40% 47 18 5-iodo-6-methoxy; mp 161-163 C; NMR (DMSO-d6) # 2.95 (s, 3H), 3.95 (s, 3H), 4.6 de 5.2 (d, J = 17Hz, 2H), *Trademark TABLE IV (Continued) PRPDUCT:N-[(prefix listed No. OF THE EXAMPLEIN below-1-NAPHTHALENYL) WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPL WAS PEEPARED GLYCINE 47 (Cont'd) 7.5 (m, 5H); IR(Nujol*) 2900, 1720 cm-Ú; UV#max (EtOH) 343 nm (# 7,900), 333 (7,250) 308 (12,400), 273 (20,500), 240 (74,200); Anal Calcd: C, 43.39% H, 3.40% N, 3.37%; Found: C, 42.75% H, 3.35% N. 3.37% 48 19 5-cyano-6-methoxy; mp 155-157 C; NMR(CDCl3)# 3.05 (s, 3H), 4.05 (s, 3H), 4.55 & 5.45 (d, J=17Hz, 2H), 7.7 (m, 5H); IR(CHCl3) 2900, 2220, 1725 cm-Ú; UV#max (EtOH) 346 nm (#5,600), 339 (5,500), 232 (46,500) *Trademark TABLE V PRODUCT:N-[[prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL] WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED GLYCINE 49 20 5-bromo-6-(3-methoxy-pro- poxy); NMR (CDCl3) # 2.1 (q, J = 6Hz, 2H), 3.0 (s, 3H), 3.35 (s, 3H), 3.65 (t, J = 6Hz, 2H), 4.25 (t, J = 6Hz, 2H), 4.55 (d, J = 16Hz, 1H), 5.4 (d, J 16Hz, 1H), 7.4 (m, 3H), 7.95 (d, J = 8Hz, 1H), 8.2 (d, J = 8Hz, 1H); IR (CHCl3) 2900, 1720 cm-1; UV#max (EtOH) 341 nm (# 3,920), 330 (3,730), 238 (49,400); Anal Calcd: C, 50.69% H, 4.73% N, 3.29%; Found: C, 50.29% H, 4.89% N, 3.23% 50 21 5-(1-methylethenyl); mp 146-148 C; NMR (CDCl3) # 2.2 (s, 3H), 3.1 (s, 3H), 4.75 & 5.35 (d, 2H), 5.05 & 5.4 (d, 2H), 7.6 (m, 6H), 8.5 (broad, 1H); IR (CHCl3) 2900, 1760, 1720 cm-1; UV#max (EtOH) 282 nm ( s14,000), 216 (38,900); Anal Calcd: C, 68.20% H, 5.72% N, 4.68%; C, 69.06% H, 6.03% N, 4.39% TABLE V (Continued) PRODUCT:N-[[prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL]- WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED GLYCINE 51 22 5-(l-methylethyl); mp 136-136 C; NMR (CDCl3)# 1.40 (m, 6H), 3.05 & 3.65 (d, 3H), 3.65 (m, 1H), 5.05 (m, 2H), 7.5 (m, 6H), 980 (broad, 1H); IR(CHCl3) 2900, 1755, 1720 cm-1; Anal Calcd: C, 67.74% H, 6.35% N, 4.65%; Found: C, 66.44% H, 6.56% N, 4.16% 52 23 5-(trifluoromethyl)-6-methoxy; mp 164-1650 C; NMR(CDCl3) 6 3.05 (s, 3R), 3.95 (s, 3H3, 4.55 & 5.4 (d, J = 17Hz, 2H), 7.6 (m, 5H), 9.8 (broad, lH); IR (CHCl3) 2900, 1720 cm-1; UV#max (EtOH) 337 nm (# 3,895), 268 (13,260), 226 (49,315); Anal Calcd: C, 53.78% H, 3.95% N, 3.92%; Found: C, 53.56% H, 3.95% N, 3.87% 53 24 5-bromo-6-(3-trifluoromethyl) phenylmethoxy]; mp 125 C; NMR (DMSO-d6) #3.0 (s, TABLE V (Continued) PRODUCT:N-[[prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL]- WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED GLYCINE 53 (Cont'd) 3H), 4.65 & 5.25 (2d, J = 17Hz, 2H), 5.5 (s, 2H), 7.8 (m, 9H); IR (Nujol #) 2900, 1720 cm-1; UV#max (EtOH) 340 nm (# 3,950), 270 (13,900), 263 (14,200), 238 (54,200); Anal Caled C, 51.57% H, 3.35% N, 2.73% Found: C, 52.11% H, 3.22% N, 2.94% 53a 24a 5-bromo-6-(4-chlorophenyl methoxy); mp 88-90 C (dec); NMR (DMSO-d6) # 2.95 (s, 3H), 4.63 & 5.20 (d, J = 17.25Hz, 2H), 5.4 (s, 2R), 7.6 (m, 9H); IR (CHCl3) 3000, 1720 cm-1; UV#max (EtOH) 340 nm (# 3,495), 326 (3, 450), 238 (53,480) 53b 24b (5-trifluoromethyl); mp 156-158 C; NMR(CDCl3) # 3.05 (s, 3H), 4.65 & 5.4 (d, J = 17Hz, 2H), 7.85 (m, 6H), 10.4 (b, 1H); IR (CHCl3) 2900, 1720 (with inflectiori at 1755), 1305 cm-1; UV#max (EtOH) 278 nm (# 12,900), 216 (68,800); Anal Calcd: C, 55.03% H, * Trademark TABLE V (Continued) PRODUCT:N-[[prefix listed NO. OF THE EXAMPLE IN below-1-NAPHTHALENYL] WHICH STARTING MATERIAL THIOXOMETHYL]-N-METHYL EXAMPLE WAS PREPARED GLYCINE 53b (Cont'd) 3.70% N, 4.27% Found: C, 54.69% H, 3.70% N, 4.27% TABLE VI PRODUCT:N-[(5-BROMO-1 NO. OF THE EXAMPLE IN NAPHTHALENYL)THIOXO- WHICH STARTING MATERIAL METHYL]-suffix listed EXAMPLE WAS PREPARED below 54 25 glycine; mp 232-2370 C; NMR (DMSO-d6) 6 45 (d, J =5.5, 2H), 7.8 (m, 6H), 10.8 (broad, 1H); IR (Nujol #) 3200, 1720; UV#max (EtOH) 275 nm (# 11,700), 217 (44,800); Anal Calcd C, 48.15% H, 3.10% N, 4.30%; Found: C, 48.65% H, 3.18% N, 4.37% 55 26 N-propylglycine; NMR (CDCl3) # 0.65 (t, J = 8Hz, 3H), 1.55 (sextet, J = 8Hz, 2H), 3.25 (t, 3 = 8Hz, 3H), 4.55 (d, J = 17Hz, 1H), 5.3 (d, J = 17Hz, 1H), 7.7 (m, 6H); IR (CHCl3) 2900, 1723 cm-Ú; UV#max (EtOH) 277 nm (# 14,800), 216 # Trademark TABLE VI (Continued) PRODUCT:N-[(5-BROMO-1 NO. OF THE EXAMPLE IN NAPHTHALENYL)THIOX0- WHICH STARTING MATERIAL METHYL]-suffix listed EXAMPLE WAS PREPARED below 55 (Cont'd) (61,200); Anal Calcd: C, 52.44% H, 4.4196 N, 3.83%; Found: C, 52.53% H, 4.44% N, 3.73% 56 27 N-(2-propylene)glycine: NMR (CDCl3)# 3.5 (m,2H), 3.9 (m, 2H), 5.4 (m, 3H), 6.95 (m,1H), 7.2-8.4 (m,6H); IR (CHCl3) 2900, 1720 with inflection at 1760 cm-Ú; UV#max (EtOH) 277 nm (# 14,400), 219(39,700); Anal Calcd: C, 52.76% H, 3.87% N, 3.84%; Found: C, 52.93% H, 4.28% N, 3.68% 57 28 N-ethylglycine; mp 182-1840 C; NMR(DMSO-d6) 6 0.95 (t, J = 7Hz, 3H), 3.25 (q, J = 7Hz, 2R), 4.58 & 5.05 (d, J = 16.5Hz, 2H), 7.7 (m,6H); IR (Nujol *) 2900, 1720 cm-Ú; UV#max (EtOH) 276 nm ( # 14,795), 219 (42,305); Anal Calcd: C, 51.14% H, 4.00% N, 3.97%; Found: C, 51.33% H, 4.08% N, 4.05% *Trademark TABLE VI (Continued) PRODUCT:N-[(5-BROMO-1 NO. OF THE EXAMPLE IN NAPHTHALENYL)THIOXO WHICH STARTING MATERIAL METHYL]-suffix listed EXAMPLE WAS PREPARED below 58 29 N-butylglycine; mp 65-68 C (dec); NMR(CDCl3) 6 0.63 (t, J = 5.5 Hz, 3H), 1.2 (m, 411), 3.25 (t, J = 7.5Hz, 2H), 4.5 & & 5.3 (d, J = 16.8Hz, 2H), 6.9 (broad, lR), 7.7 (m, 6H); IR(CHCl3) 2900, 1720 cm-Ú; UV#max (EtOH) 378 nm 13,900), 219 (42,000) 59 30 N-(phenylmethyl)glycine; mp 980 C(decomp); NMR(CDC13)6 4.5 & 5.35 (d, 2H), 4.45 (m, 2H), 7.6 (m, 11H); IR(Nujol *) 2900, 1710 cm-Ú; UV#max (EtOH) 278 nm (15,620), 219 (43,465); Anal Calcd: C, 58.01% H, 3.94% N, 3.35%: Found: C, 58.29% H, 4.27% N, 3.2496 EXAMPLE 60 N-[(5-Bromo-1-naphthalenyl)carbonyl]-N-methylglycine (IV, RÚ=CH3,R = 5-Br and R4 and R5 = B) N-[(5-Bromo-1-naphthalenyl)carbonyl]-N-methylglycine methyl ester (3.7 g, 11.0 mmoles, a compound of formula II described in Example 2) was suspended in methanol (50 ml). A solution of 1N aqueous NaOH (13.2 ml) was added to * Trademark the suspension. The mixture was stirred at 20-22 C for 1.5 hr. The mixture was neutralized with aqueous HC1 and concentrated under reduced pressure to remove the methanol. The residual solution was made acidic with aqueous HCl and extracted with ethyl acetate. The extract was dried (MgS04), filtered and evaporated to dryness. The residue was crystallized from ethanol-water to give 3.25 g of the title compound; mp 2050 C; NMR (DMSO-d6) 6 2.75 & BR< 3.10 (2s, 3H), 2.75 & 3.10 (2s, 3H), 3.75 & & 4.25 (2s, 2H), 7.3 - 8.3 (m, 6H); IR (Nujol * ) 1745 with inflection at 1720, 1580 cm4; UVXmax (EtOH) 322 nm (e 680), 316 (1,000), 299 (6,510), 289 (9,055), 279 (7,150) 226 (63,080); Anal Calcd: C, 52.19% H, 3.76% N, 4.35%; Found: C, 52.09% H, 38.4% N, 4.48%. By following the procedure of example 60 but replacing N-[(5-bromo- 1-naphthalenyl)carbonyl]-N-methylglycine methyl ester with an equivalent amount of another ester compound of formula II in which R is lower alkyl or arflower)- alkyl, the corresponding compound of formula IV is obtained. For example, replacement with N-[(5-(trifluoromethyl)-6-methoxy-1-naphthalenyl] carbonyl] N-methylglycine methyl ester, NMR (CDC13) 6 2.85 (s, 3H), 3.5 - 4.5 (m, 2H), 3.4 & 3.75 (2s, 6H), 7.0 - 8.4 (m, 5H), prepared according to the procedure of example 2, gives N-[[5-(trifluoromethyl)-6-methoxy-1-naphthanenyl] carbonyl] N-methylglycine, mp 174-175 C; NMR (DMSO-d6) 6 2.75 de 3.1 (2s, 3R), 4.03 (s, 3H), 4.30 (d, 2H), 7.8 (m, 5H); IR (Nujol * ) 2500, 1720 with inflection at 1745, 1580 cm-Ú; UV#max (EtOH) 335 nm ( #3,050), 322 (2,700), 295 (5,100), 283 (5,750), 275 (4,450), 220 (57,100); Anal Calcd: C, 56.30% H, 4.13% N, 4.10%; Found: C, 55.29% H, 4.02 N, 3.99%. EXAMPLE 61 4,6-Dimethoxy-1-naphthalenecarboxylic Acid (V, R3 = 4-CR30, R4 = 6-CH3O and R5 = H) A stream of chlorine gas was passed through a cooled solution of NaOH (17.28 g, 0.432 mole) in water (24 ml) containing 100 g of ice until 12.7 g [0.18 mole) of chlorine was absorbed into the solution. Solid (4,6-dimethoxy l-naphthalenyl)ethanone [9.2 g, 0.04 mole, described by N.P. Buu-Hoi, J. Org. Chem., 21, 1257 (1956)], was added at 20-22 C to the chlorine solution. The mixture was stirred at 550 C for one hr, cooled in an ice bath and treated with NaHSO3 (5 g) in water (20 ml). The mixture was made neutral by the addition * Trademark of dilute HCI. The resulting precipitate was collected, washed well with water, dried over P205 and recrystallized from methanol to give 4,S-dimethoxy-l-naph- thalenecarboxylic acid (7.0 g); mp 227.2290 C; NMR (DMSO-d6) 6 3.85 (s, 3H), 4.0 (5, 3H), 7.7 (m, 5H); IR (white mineral oil) 2900, 1570 cm4; UV#max (MeOH) 339 nm ( ±4,910), 328 (4500), 304 (8,180), 240 (40,100); Anal Calcd: C, 57.23% H, 5.21%; Pound: C, 67.15% H, 5.23%. EXAMPLE 62 4,6-Dimethoxy-5-(trifluoromethyl)-1-naphthalenecarboxylic Acid (V, R3 = 4- CR3O, R4 = 5-CF3 and R5 = 6-CH3O] 4,6-Dimethoxy-1-naphthalenecarboxylic acid (98.5 g, 0.425 mole, described in Example 61) was added to an ice-cooled solution of 12 (59.5 g, 0.5 mole) in anhydrous methanol (225 ml). The mixture was heated at reflux for 18 hr. Another portion of SOCl2 (35.5 ml) was added and the reflux was continued for another 7 hr. The mixture was extracted with diethyl ether. The ether extract was washed with water and then aqueous NaHCO3 solution, dried (Na2SO4) and concentrated to dryness. The solid residue was crystallized from methanol (720 ml) to give 64.5 g of 4,6-dimethoxy-1-naphthalenecarboxylic acid methyl ester; mp 102-1040 C; NMR (CDCi3) Ï 3.9 (s,6H), 4.0 (s, 3H), 7.7 (m,5H). The latter compound (4.93 g, 0.02 mole) was suspended in 20% (v/v) aqueous acetic acid and concentrated H2SO4 (0.279 ml). The mixture was stirred and heated at 600 C. Iodine (2 g, 0.008 mole) and periodic acid (2.76 g, 0.012 mole) was added to the mixture. The reaction mixture was stirred for one hr at the same temperature, cooled, poured into water and extracted with chloro form. The chloroform extract was washed with aqueous sodium bisuiphite solution, washed with water and dried (Na2SO4). The chloroform extract was poured onto a column of 250 g of silica gel (prepared with 10% (v/v) ethyl acetate in hexane). The column was eluted with L5 liters of the same solvent system and then with 20% (v/v) ethyl acetate in hexane. The appropriate fractions were combined to give 5-iodo-4,6-dimethoxy-1-naphthalenecarboxylic acid methyl ester (L4 g, 80% pure). The pure compound, mp 120-1220 C, was obtained by crystallization from ethyl acetate-hexane. A mixture of the latter compound (7 g, 0.019 mole), freshly prepared copper powder (4.5 g, prepared according to the procedure of R.Q. Brewster and T. Groening, "Organic Synthesis", Coll. Vol. II, John Wiley and Sons, New York, N.Y., U.S.A., 1948, p. 445), trifluoromethyl iodide (8.5 g, 0.43 mole) and dry pyridine (35 ml) was heated for 20 hr at 1200 C in an autoclave. After cooling to 22 to 24 C, the mixture was taken up in toluene and the toluene suspension was filtered. The filtrate was concentrated to dryness under reduced pressure. The residue was dissolved in chloroform. Insoluable material in the chloroform solution was removed by filtration. The filtrate was passed through a column of 75 g of silica gel and the column was eluted with chloroform. The pure fractions were combined and crystallized from ethyl acetate hexane to give 2.83 g of 4,s-dimethoxy-5-(trifluoromethyl)-1-naphthalenecarboxyli c acid methyl ester; mp 120-1230 C, NMR (CDCl3) 6 3.95 (m, 9H), 6.8 and 8.05 (2d, J = 10Hz, 2H), 7.21 and 9.1 (2d, J = 10Hz, 2H). A suspension of the latter compound (2.83 g, 0.009 mol) in methanol (36.2 ml) and NaOH (5.4 ml of a 4N aqueous solution) was heated at reflux under nitrogen for 10 min. The resulting clear solution was cooled in an ice bath and rendered acid (pR = 3) with 2N aqueous HCI. The precipitate was coIlected, washed with water and dried over P205 to give 2.7 g of the title compound, m/e 300 (M +). EXAMPLE 63 5-(Trifluoromethylthio)-6-methoxy-l-naphthalenecarboxylic Acid(Y, R3 = 5 4 CF3S, R = S-CH3O and R5 = H) An intimate mixture of copper dust (1.84 g, 29 mmoles) and Hg (SF3)2 [3.27 g, 8 mmoles, prepared according to the method of E.H. Man et al., J. Amer. Chem. Soc., 81, 3575 (1959)@ was heated between 80 to 1000 C for 2.5 hr. There after, the temperature was increased to 1500 C for 30 min. The mixture, con taining CuSCF3, was cooled to room temperature (ca. 22 to 240 C). A solution of 5-iodo-6-methoxy-1-naphthalenecarboxylic acid methyl ester (1.87 g, 5.4 mmoles, described in example lf) in distilled dimethylformamide (DMF, 10 ml) was added to the mixture. The resulting mixture was stirred at 110 to 1200 C for 3 hr, and then at room temperature for 18 hr. The mixture was poured into water. The diluted mixture was extracted with diethyl ether (3 x). The extract was washed with water, dried (MgS04) and evaporated to dryness to give the corresponding methyl ester of the title compound (1.7 g) as a solid residue; mp 93-94 C; NMR (CDC13) . 3.90 (s, 3H), 4.00 (s, 3H), 7.00-9.20 (m, 5H). The latter ester compound (2.45 g, 7.7 mmoles), dissolved in 2-methoxyethanol (60 ml), was mixed with an aqueous NaOH solution (1H, 15.5 ml). The resulting solution was stirred at room temperature for 24 hr, cooled in an icebath, made acidic (pH=3) by the addition of 1N aqueous HCl and diluted with water. The resulting solid was collected, washed with water and recrystallized from ethanol to give the title compound (1.7 g); mp 204-2050 C; NMR (DMSO d) 6 4.00 (s, 3H), 8.20 (m, 5H), 10.30 (broad, 1H). EXAMPLE 64 (a) By following serially the procedures of examples 2 and 3 and using an equivalent amount of 4,6-dimethoxy-l-naphthalenecarboxylic acid of example 61 instead of 5-bromo-l-naphthalenecarboxylic acid; N-[(4,6-dimethoxy-1-naph- thalenyl)thioxomethyl]-N-methylglycine methyl ester (I, R1 and R2 = CH3, =4-CH3O, R4=6-CH3O and R5=H); mp 105-107 C; NMR (CDCl3)# 3.05 (s, 3H), 3.85(s, 3H), 3.90 (s, 3H), 4.0 (s, 3H), 4.8 (2d, J = 20 Hz, 2H), 7.3 (m,5H); was obtained via N-[(4,6-dimethoxy-1-naphthalenyl)carbonyl]-N-methylglycine methyl ester; NMR (CDCl3) # 2.75 (s,1H), 3.7 (s,3H), 3.9 (s,3H), 4.0 (s,3H), 4.35 (s, 2H), 74 (m, 5H). (b) Likewise, the substitution of an equivalent amount of 6-methoxy l-naphthalenecarboxylic acid, described by C.C. Price et al., J. Am. Chem. Soc., 69, 2261(1947), gives N-[(6-methoxy-1-naphthalenyl)thioxomethyl] -N-methyl glycine methyl ester (I, R1 and R2 - CH3, R3 = 6-methoxy, and R4 and 5 = H), NMR (COCl3) 6 3.02 (s, 3H), 3.86 (s, 3R), 3.89 (s, 3H), 4.53 de 4.35 (d, J=17Hz, 2H), 6.90-8.10 (m, 6 H), via N-[(6-methoxy-1-naphthalenyl)carbonyl]-N-methylglycine methyl ester. (o) Likewise the substitution of an equivalent amount of 4,5-dimethoxy 5-(trifluoromethyl)-l-naphthalenecarboxylic acid of example 62 gives N-1[4,6- dimethoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine methyl ester (I, R1 and R2 = CH3O, R3 = 4-CH30, R4 = 5-CF3 and R5=6-CH3O), NMR (CDCl3) 6 3.0 (s, 3H), 3.7 (5, 3H), 3.85 (s,3H), 3.95 (s, 3H), 4.35 & 5.45 (2d, J =17Hz, 2H), 6.8-8.2 (m, 4H), via N-[[4,6-dimethoxy-5-(trifluoromethyl) 1-naphthalenyl] carbonyl] -N-methylglycine methyl ester, NMR (CDC13) 6 2.78 (s, 3H), 3.6 (s, 3H), 3.85 (s, 3H), 3.9 e, 3H), 4.35 (m, 2H), 6.7-8.3 (m, 4H). (d) Likewise, the substitution of an equivalent amount of S-(trifluoro- methylthio)-6-methoxy-1-naphthalenecarboxylic acid of example 63 gives N [(5-(trifluoromethylthio)-6-methoxy-1-naphthalenyl] thioxomethyl]-N-methylglycine methyl ester (I, R1 and R2 = CH3, R3 5-CF3S, R4 = 6-CH3O and R5 = H); mp 121-1230 C; NMR (CDC13) 6 3.00 (sm 3H), 3.75 (s, 3R), 4.00 (s, 3H), 4.35 & 4.5 (d, 2H), 7.0-8.5 (m, Shy; via N-1[5-(trifluoromethyIthio)-6-methoxy- l-naphthalenyl] carboxyl]-N-methylglycine methyl ester, NMR (CDCl3) 6 3.00 (s, 3H), 3.75 (s, 3R), 4.00 (s, 3H), 4.35 and 4.50 (d, 2R), 7.0-8.5 (m, 5H). EXAMPLE 65 By following the procedure of Example 32, but replacing N-[(5-bromo1-naphthalenyl)thioxomethyl]-N-methylglycine methyl ester with an equivalent amount of one of the ester compound of formula I in which R2 is lower alkyl, described in example 64, the corresponding compoundsof formula I in which R2 is hydrogen was obtained, namaly(a)N-[(4,6-dimethoxy-1-naphthalenyl)thioxo- methyl]-N-methylglycine; NMR (DMSO-d6) # 3.05 (s,3H) 3.90 (s,3H), 3.97 (s, 3H), 4.27 & 4.67 (2d, J = 17Hz, 2H), 6.50-8.00 (m, 5H), 9.12 (broad, lH); IR (CHCl3) 2900, 1720 cm-Ú; UV#max (MeOH) 337 nm (# 10,280), 322 (9,675), 278 (35,385) shoulder at 242 (66,830), 224 (114,600); Anal Calcd: C, 60.17% H, 5.36% N, 4.38%; Found: C, 58.38% H, 5.20% N, 4.80%;(b)N-[(6-methoxy-1-naphthalenyl)- thioxomethyll -N-methylglycine; mp 153-1540 C, NMR (DMSO-d6) a 2.95 (s, 3H), 3.9 (5, 3H), 4.65 and 5.2 (2d, J = 16.5Hz, 2H), 7.5 (m, 6H);(c)N-[(4,6-dimethoxy- 5-(trifluoromethyl)-1-naphthalenyl] thioxomethyl]-N-methylglycine; NMR (CDCl3)# 3.05 (s, 3R), 3.9 (s, 3H), 3.95 (s, 3R), 4.5 & 5.11 (2d, J = 17Hz, 2H), 6.75 (s, 1H), 7.2 (m, 4H); IR (CHCl3) 3000, 1720, 1270, 1130 cmA; Anal Calcd: C, 52.70% H, 4.16% N, 3.61%; Found: C, 52.83% H, 4.46% N, 3.57%and(d)N-[[5-(trifluoromethylthio)- 6-methoxy-1-naphthalenyl] thioxomethyl]-N-methylglycine; mp 168-169 C; NMR (DMSO-ds) 63.0 (s, 3H), 4.0 (s, 3H), 4.6 & 5.2 (d, J = 16.5 Hz, 2H), 7.7 (m, 5H); IR (white mineral oil) 2900, 1720, 1465 cm-Ú; UV#max (MeOH) 342 nm (#4970), 334 (4800), 230 (46,800).

Claims: CLAIMS 1. A compound of formula I EMI52.1 wherein R1 is hydrogen, lower alkyl, lower alkenyl or phenylmethyl; Rn is hydrogen or lower alkyl; R3 is hydrogen, a lower alkoxy at position 6 of the naphthalene ring, or a substituent at position 4, 5 or 8 of the naphthalene ring, the substituent being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro, trihalomethyl and trifluoromethylthio, and R4 and R5 each is hydrogen; or R3 and R4 each is a substituent at different positions selected from positions -S to 7 of the naphthalene ring, the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, trihalom ethyl, trihalomethylthio, (lower)alkoxyaower)aIkoxy, phenylm ethoxy and phenylmethoxy substituted on the phenyl portion with a lower alkyl, lower alkoxy, halo or trihalomethyl, and R5 is hydrogen; or R3, R4 and R5 each is a substituent at different positions selected from positions 4,5 and 6 of the naphthalene ring, the substituent being selected from the group consisting of lower alkoxy, halo and trihalomethyl; or a therapeutically acceptable salt with an organic or inorganic base of the compound of formula I wherein R2 is hydrogen. 2. A compound of claim 1 wherein R1 is hydrogen, lower alkyl, 2-propenyl or phenylmethyl; R2 is hydrogen or lower alkyl; R3 is hydrogen, a lower alkoxy at position 6 of the naphthalene ring, or a substituent at positions 4, 5 or 8 of the naphthalene ring, the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro and trifluorow 3 methyl, and R4 and R" each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring, each substituent being at a different position of the ring, the pair of substituents being selected from the group of pairs consisting of 3-halo-4-lower alkoxy, 4,S-di(lower alkoxy), 5-halo-S-lower alkyl, 5-halo 6-lower alkoxy, 5,7-dihalo, 5-(trifluoromethylr-6-lower alkoxy, 5-(trifluoromethylthio)-6-lower alkoxy, 5-halo-6-(lower)alkoxy(low er)alkoxy, 5-halo 6- [3-(trifluoro m e thyl)phenylm ethoxy3 and 5-halo-6-(4-chlorophenylm ethoxy), and R5 is hydrogen; or R3, d and R5 each is a subtituent on the naphthalene ring, each of the three substituents being at different positions on the ring, the three substituents being selected from the group of 4-lower alkoxy-5halo-6-lower alkoxy and 4,6-di(lower alkoxy)-5-(trifluoromethyl); or when R2 is hydrogen a therapeutically acceptable salt thereof with an organic or inorganic base. 3. A compound of claim 1 wherein R1 is hydrogen, lower alkyl or phenylmethyl; R2 is hydrogen or lower alkyl; R3 is 4-halo or 5-halo and R4 and R5 each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring selected from the group of pairs consisting of 3-halo-4-lower alkoxy, 4,6-di(1ower alkoxy), 5-halo-6-lower alkyl, 5-halo-6-lower alkoxy, S, 7-dihalo, 5-(trifluorom ethyl)-6-lower alkoxy and 5-(trifluorom ethylthio)- 6-lower alkoxy, and R5 is hydrogen; or R3is Glower alkoxy, R4 is S-(trifluorometh- yl) and R5 is 6-lower alkoxy; or when R2 is hydrogen a therapeutically acceptable salt thereof with an organic or inorganic base. 4. A compound of claim 1 wherein R1 is lower alkyl; R2 is hydrogen; R3 is 5-halo and R4 and R5 each is hydrogen; or R and R4 are a pair of substituents on the naphthalene ring selected from the group of pairs consisting of 3-halo-4-lower alkoxy, 5-halo-6-lower alkoxy, 5-(trifluoro methyl)-6-lower alkoxy and 5-(trifluoromethylthio)-6-lower alkoxy, and R5 is hydrogen; or R3 is 4-lower alkoxy, R4 is S-(trifluoromethyl) and R5 is 6 lower alkoxy; or a therapeutically acceptable salt thereof with an organic or inorganic base. 5. A compound of claim 1 which is N-[(5-bromo-1-naphthalenyl)thioxo- methyl]-N-methylglycine, N-[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl] thioxo methyl]-N-methylglycine or N-[[5-(trifluoromethylthio)-6-methoxy-1-naphthalen yl] thioxomethyl] -N-methylglycine, or the corresponding methyl ester thereof. 6. A compound of claim 1 which is N-±(S-ch1orl-naphthal- enyl)thioxomethyl]-N-methylglycine, N-[(5-bromo-6-methoxy-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(3-chloro-4-methoxy-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-(5,7-dichloro-1-napthalenyl)thioxomethyl] N-methylglycine, N-[[-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl-Nmethylglycine, N-[(3-chloro-4-methoxy-1-naphthalenyl)thioxomethyl] glycine, or N-[[4,6-dimethoxy-5-(trifluoromethyl)-1-naphthalenyl] thioxomethyl]-Nmethylglycine, or the corresponding methyl ester thereof. 7. A compound of claim 1 which is N-1(4-bromo-%-naphthalenyl)- thioxomethyl]-N-methylglycine, N-[(8-bromo-1-naphthalenyl)thioxomethyl] N-methylglycme, N-[(5-methoxy-1-naphthalenyl)thioxomethyll-N-methyl- glycien, N-[(5-methyl-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5 bromo-6-pentyloxy-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5 cyano-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-nitro-1-naphthal enyl)thioxomethyl]-N-methylglycine, N-[(5-bromo-6-methyl-1-naphthalenyl)thioxo methyl]-N-methylglycine N-[(1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(4-chloro-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-iodo-6 methoxy-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-cyano-6-methoxy 1-naphthalenyl)thioxom ethyl] -N-m ethylglycine, N-[[5-bromo-6-(3-methoxypro- poxy)-l-naphthaleny1] thioxom ethyl] -N-methylglycine, N-[!5-(l-m ethylethenyl) l-naphthalenyl] thioxom ethyl] -N-methylglycine, N0[[5-(1-methylethyl)-1-naphthal- enyl] thioxomethyl]-N-methylglycine, N-[[5-bromo-6-[3-(3-(trifluoromethyl) phenylmethoxy]-1-naphthalenyl] thioxom ethyl] -N-methylglycine, N-[[5-bromo 6-(4-chlorophenylmethoxy)-1-naphthalenyl] thioxomethyl]-N-methylglycine, N-[(5-bromo-1-naphthalenyl)thioxomethyl] glycine, N-[(5-bromo-1-naphthalenyl) thioxomethyl]-N-propylglycine, N-[(5-bromo-1-naphthalenyl) thioxomethyl] N-(2-propenyl)glycine, N-[(5-bromo-1-naphthalenyl)thioxomethyl]-N-ethyl glycine, N-[(5-bromo-l-naphthalenyl)thioxom ethyr] -N-butylglycine, N-[(5 bromo-1-naphthalenyl) thioxomethyl]-N-(phenylmethyl)glycine, N-[(4-cyano 1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(4,6-dimethoxy-1-naphthalenyl) thioxomethyl] -N-rnethylglycine,c(6-methoxy-l-naphthalenyl)thioxomethyl] N-methylglycine, or the corresponding methyl ester thereof. 8. A pharmaceutical composition for preventing or relieving diabetic complications in a diabetic mammal, which comprises a compound as claimed in any one of claims 1 to 7 and a phannaceutically acceptable carrier. 9. A compound as claimed in any one of claims 1 to 7 for use as an agent for preventing or relieving a diabetic complication in a diabetic znaamal. 10. A compound of the formula EMI55.1 wherein R1 is lower alkyl, lower alkenyl or phenylmethyl; R3 is a substituent at position 4, 5 or 8 of the naphthalene ring, the substituent being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro and trihalomethyl, and R4 and R5 each is hydrogen; or R3 and R4 each is a substituent at different positions of the naphthalene ring, the positions selected from positions 3 to 7 and the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, trihalomethyl, trihalomethyl- thio, (lower) alkoxy(lower)alkoxy, phenylmethoxy and phenylmethoxy substituted on the phenyl portion with a lower alkyl, lower alkoxy, halo or trihalomethyl and R5 is hydrogen; or R3, R4 and R5 each is a substituent at different positions selected from positions 4, 5 and 6 of the naphthalene ring, the substituent being selected from the group consisting of lower alkoxy, halo and trihalo- methyl; and R is hydrogen or lower alkyl or a therapeutically acceptable salt with an organic or inorganic base of the compound wherein R is hydrogen. 11. A process for preparing a compound claimed in claim 1 which comprises: (a) reacting an amidoester of formula II EMI56.1 wherein R1, R3, R4 and R5 are as defined in claim 1 and R is lower alkyl with phosphorus pentasulfide to obtain the corresponding compound of claim wherein R11 R3, R4 and R5 are as defined herein and R2 is lower alkyl; or (b) hydrolyzing the compound of formula m EMI56.2 wherein R1, R3, R4and R5 are as defined in claim landR is lower alkyl or ar(lower) alkyl to obtain the corresponding compound of formula I wherein RÚ, R , R4 and R5 are as defined herein and Rê is hydrogen; or (c) reacting an amidoacid of formula (IV) EMI56.3 wherein R1, R3, R4 and R5 are as defined in claim 1 with phosphorus pentasulfide to obtain the corresporlding compound of claim 1 wherein R, R3,R4 and R5 are as defined herein and R2 is hydrogen; and, (d) if required, transforming the compound of formula I wherein R2 is hydrogen into a corresponding therapeutically acceptable salt of an organic or inorganic base. 12. The process of claim 11 wherein the compound of formula II is obtained by coupling a compound of formula V EMI57.1 wherein R3 R4 andR5 are as defined therein with an aminoacid ester of the formula NH(RÚ)-CH2COOR wherein RÚ and R are as defined therein. CLAIMS FOR AUSTRIA 1. A process for preparing a compound of formula I EMI58.1 wherein R1 is hydrogen, lower alkyl, lower alkenyl or phenylmethyl; R2 is hydrogen or lower alkyl; R is hydrogen, a lower alkoxy at position 6 of the naphthalene ring, or a substituent at position 4, 5 or 8 of the naphthalene ring, the substituent being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro, trihalomethyl and trifluoromethylthio, and R4 and R5 each is hydrogen; or R and R4 each is a substituent at different positions selected from positions 3 to 7 of the naphthalene ring, the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, trihalomethyl, trihalomethylthio, (lower)alkoxy(lower)alkoxy, phenylmethoxy and phenyimethoxy substituted on the phenyl portion with a lower alkyl, lower alkoxy, halo or trihalomethyl, and R5 is hydrogen; or R , R4 and R5 each is a substituent at different positions selected from positions 4,5 and 6 of the naphthalene ring, the substituent being selected from the group consisting of lower alkoxy, halo and trihalomethyl; or a therapeutically acceptable salt with an organic or inorganic base of the compound of formula I wherein Rê is hydrogen; which comprises: (a) reacting an amidoester of formula II EMI58.2 wherein R1, R3, R4 and R5 are as defined herein and R is lower alkyl with phosphorus pentasulfide to obtain the corresponding compound of claim 1 wherein Rl, R3, R4 and R5 are as defined herein and R2 is lower alkyl; or (b) hydrolyzing the compound of formula m EMI59.1 wherein R1, R3, R4 and R5 are as defined herein and R is lower alkyl or ar(lower)- alkyl to obtain the corresponding compound of formula I wherein R1, R3, R4 and R5 are as defined herein and R2 is hydrogen; or (c) reacting an amidoacid of formula IV EMI59.2 wherein R1, R3, R4 and R5 are as defined herein with phosphorus pentasulfide to obtain the corresponding compound of claim 1 wherein R1, R3, R4 and R5 are as defined herein and R2 is hydrogen; . or (d) transforming a compound of formula I wherein R2 is hydrogen into a corresponding therapeutically acceptable salt of an organic or inorganic base. 2. The process of claim 1, paragraph (a) or (b), wherein R1 is hydrogen, lower alkyl, 2-propenyl or phenylmethyl; R2 is hydrogen or lower alkyl; R3 is hydrogen, a lower alkoxy at position 6 of the naphthalene ring, or a substituent at positions 4, 5 or 8 of the naphthalene ring, the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, cyano, nitro and trifluoromethyl, and R4 and R5 each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring, each substituent being at a different position of the ring, the pair of substituents being selected alkoxy), 5-halo-6-lower alkyl, 5-halo-6-lower alkoxy, 5,7-dihalo, 5-(trifluoro m ethyl)-6-lower alkoxy, 5-(trifluoromethylthiot6-.ower alkoxy, 5-halo-6- (lower)alkoxy(lower)alkoxy, 5-halo-6-[3-(trifluoromethyl)phenylmethoxy] and 5-halo-6-(4-chlorophenylmethoxy), and R5 is hydrogen; or R3, R4 and R5 each is a subtituent on the naphthalene ring, each of the three substituents being at different positions on the ring, the three substituents being selected from the group of 4-lower alkoxy-5-halo-S-Iower alkoxy and 4,6-di(lower alkoxy)-5-(trifluoromethyl). 3. The process of claim 1, paragraph (a) or (b), wherein R1 is hydrogen, lower alkyl or phenylmethyl; Rê is hydrogen or lower alkyl; R3 is 4-halo or 5-halo and R4and R5 each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring selected from the group of pairs consisting of 3-halo-4-lower alkoxy, 4,6 di(lower alkoxy), 5-halo-S-lower alkyl, S-halo-6-Iow er alkoxy, 5,7-dihalo, 5-(trifluoromethyf)-6-lower alkoxy and 5-(trifluoromethylthio)-6-lower alkoxy, and R5 is hydrogen; or R3 is 4lower alkoxy, R is 5-9trifluoromethyl) and R is lower alkoxy. 4. The process of claim 1, paragraph (b), wherein R1 is lower alkyl; R is hydrogen; R3 is 5-halo and R4 and R5 each is hydrogen; or R3 and R4 are a pair of substituents on the naphthalene ring selected from the group of pairs consisting of 3-halo-4-lower alkoxy, 5-halo-S-lower alkoxy, 5-(trifluoromethyl)-6-lower alkoxy and 5-(trifluoromethylthio)-6-lower alkoxy, and R5 is hydrogen; or R3 is 4-lower alkoxy, R4 is 5-(trifluoromethyl) and R5 is lower alkoxy. 5. The process of claim 1 wherein the compound of formula I which is prepared is N-[(5-bromo-1-naphthalenyl)thioxomethyl]-N-methyl- glycine, N-[[5-(trifluoromethyl)-S-m ethoxy-l-naphthalenyl] thioxom ethyl] - N-methylglycine or N-[[5-(trifluoromethylthio)-6-methoxy-1-naphthalenyl]thioxomethyl] -N-methylglycine, or the corresponding methyl ester thereof. 6. The process of claim 1 wherein the compound of formula I which is prepared is N-[(5-chloro-1-naphthalenyl)thioxomethyl]-N-methyl- glycine, N-[(5-bromo-6-methoxy-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(3-chloro-4-methoxy-1-naphthalenyl)thioxomethyl]-N-methylglycine, N [(5,7-dichloro-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[[5-(trifluoro m ethyl)-1-naphthalenyl] thioxom ethyl-N-methylglycine, N-[(3-chloro-4-m ethoxy- 1-naphthalenyl)thioxomethyl] glycine, or N-[[4,6-dimethoxy-5-(trifluoromethyl) l-naphthalenyl] thioxomethyl] -N-methylglycine, or the corresponding methyl ester thereof. 7. The process of claim 1 wherein the compound of formula 1 which is prepared is N-[(4-bromo-1-naphthalenyl)thioxomethyl]-N-methyl- glycine, N-[(8-bromo-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-t(5- methoxy-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-methyl-1naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-bromo-6-pentyloxy-1naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-cyano-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-nitro-1-naphthalenyl)thioxomethyl] N-methylglycine, N-t(5-bromo-6-methyl-1-naphthalenyl)thsoxomethyl]-N- methylglycine, N-[(1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(4 chloro-1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-iodo-6-methoxy 1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(5-cyano-6-methoxy-1 naphthalenyl)thioxomethyl]-N-methylglycine, N-[[-5-bromo-6-(3-methoxypro poxy)-1-naphthalenyl] thioxomethyl]-N-methylglycine, N-[[5-(1-methylethenyl) 1-naphthalenyl] thioxomethyl]-N-methylglycine, N-[[5-(1-methylethyl)-1-naphthal enyl] thioxomethyl]-N-methylglycine, N-[[5-bromo-6-[3(3-(trifluoromethyl) phenylmethoxy]-1-naphthalenyl] thioxomethyl]-N-methylglycine, N-[[5-bromo 6-(4-chlorophenylmethoxy)-1-naphthalenyl] thioxomethyl]-N-methylglycine, N-[(5-bromo-1-naphthalenyl)thioxomethyl] glycine, N-[(5-bromo-1-naphthalenyl) thioxomethyl]-N-propylglycine, N-[(5-bromo-1-naphthalenyl)thioxomethyl] N-(2-propenyl)glycine, N-[(5-bromo-1-naphthalenyl)thioxom ethyl] -N-ethyl glycine, N-[(5-bromo-1-naphthalenyl)thioxomethyl]-N-butylglycine, N-[(5 bromo-1-naphthalenyl)thioxomethyl]-N-(phenylmethyl)glycine, N-[(4-cyano 1-naphthalenyl)thioxomethyl]-N-methylglycine, N-[(4,6-dimethoxy-1-naphthal enyl)thioxomethyl]-N-methylglycine, N-[(6-methoxy-1-naphthalenyl)thioxo methyl] -N-methylglycine, or the corresponding methyl ester thereof. 8. A process for preparing a pharmaceutical composition character rized in that a compound of formula I as defined in claim 1, or when R2 is hydrogen a therapeutically acceptable acid addition salt thereof with an organic or inorganic base, is mixed with a pharmaceutically acceptable carrier. 9. A process for preparing a compound of formula II EMI62.1 wherein RÚ ,R3,R4 and R5 are as defined in claim 1 and R is lower alkyl or ar(lower)-alkyl, which comprises coupling a compound of formula V EMI62.2 wherein 23,R4 and R5 are as defined therein with an amino ester of the formula NH(RÚ)-CH2COOR wherein RÚ and R are as defined therein. 10. A process for preparing a compound of the formula EMI63.1 wherein 9 is lower alkyl, lower alkenyl or phenylmethyl; ; R3 is a substituent at position 4,5 or 8 of the naphthalene ring, the substituent being selected from the group consisting of lower alkyl, lower alkoxy, halo, gyano, nitro and trihalomethyl, and @4 and R5 each is hydrogen; or R3 and R4 each is a substituent at different positions of the naphthalene ring, the positions selected from positions 3 to 7 and the substituents being selected from the group consisting of lower alkyl, lower alkoxy, halo, trihalometbyl, trihalomsthylthio, (lower)alkoxy(lower)alkoxy, phenylmethoxy and phenylmethoxy substituted on the phenyl portion with a lower alkyl, lower alkoxy, halo or trihalomethyl and R5 is hydrogen; or R3,R4 and R5 each is a substituent at different positions selected from positions 4,5 and 6 of the naphthalene ring, the substituent being selected from the group consisting of lower alkoxy, halo and trihalomethyl; and R is hydrogen or lower alkyl; or a therapeutically acceptable salt with an organic or inorganic base of the compound wherein R is hydrogen which process comprises (a) coupling a compound of formula EMI63.2 where R , R4 and R4 are as defined above with an amino ester of formula NH(RÚ)-CH2COOR wherein R1 is as defined above and R is lower alkyl to give a compound of formula (A) in which R8,R3,R4 and R5 are as defined above and R is lower alkyl; or (b) hydrolysing an amidoester of formula EMI64.1 where RÚ, R3, R4 and are as defined above and R is lower alkyl or ar(lower)alkyl to give a compound of formula A in which R ,R3, R4 and R5 are as defined above and R is hydrogen; or (c) reacting a naphthalenecarboxylic acid chloride of formula EMI64.2 where R3, R4 and R5 are as defined above with an aminoacid of formula NH(RÚ)-CH2COOH where RÚ is as defined above, in presence of a base to give a compound of formula A wherein R1, R3, R4 and R5 are as defined above and R is hydrogen; or (d) transforming a compound of formula A where R is hydrogen into a corresponding thereapeutically acceptable salt of an organic or inorganic base.

Inventors: ABRAHAM NEDUMPARAMBIL ABRAHAM, BELLINI FRANCESCO, HUMBER LESLIE GEORGE, SESTANJ KAZIMIR, TREASURYWALA ADI, ABRAHAM, NEDUMPARAMBIL ABRAHAM, BELLINI, FRANCESCO, HUMBER, LESLIE GEORGE, SESTANJ, KAZIMIR, TREASURYWALA, ADI
Applicants: AYERST MCKENNA & HARRISON, AYERST, MCKENNA AND HARRISON INC.
Application year: 1982
Main classification: C07C153
IPC codes: C07C63, C07C65, C07C69, C07C233, C07C327