HERBICIDAL SULFONAMIDES

Abstract: Compounds of the formula wherein J is and Q is O, S or SO₂; R, R₁, R₂, R₃, R₄ are H or various organic groups, or R₁ can be halogen; R₅, R₆, R₇, R₈ and R₉ are various organic groups;

Description: Title BA-8466-A/8493 Cognate ',Herbicidal sulfonamides" Background of the Invention This invention relates to novel benzofuran, benzothiophene, l-benzopyran, l-benzothiopyran, l-benz- oxepin, and l-benzothiepin sulfonamides and their agriculturally suitable salts which are useful as plant growth regulants and herbicides. The invention also includes intermediates useful for the synthesis of these compounds. Netherlands Patent 121,788, published September 15, 1966, discloses the preparation of compounds of the following Formula and their use as general or selective herbicides: EMI1.1 wherein R1 and R2 may independently be alkyl of 1-4 carbon atoms; and R3 and R4 may independently be hydrogen, chlorine or alkyl of 1-4 carbon atoms. U.S. Patent 3,637,366 discloses compounds having the formula: EMI1.2 wherein R1 is hydrogen or lower saturated aliphatic acyl and R2 is hydrogen, 2-pyrimidinyl, pyridyl, amidino, acetyl or carbamoyl. The disclosed compounds are said to provide control of crabgrass, cress, endive, clover and Poa annua. French Patent No. 1,468,747 discloses the following para-substituted phenylsulfonamides as being useful as antidiabetic agents: EMI2.1 wherein R = H, halogen, CF3 or alkyl. Logemann et al., Chem. Ab., 53, 18052g (1959), disclose a number of sulfonamides, including uracil derivatives and those having the formula: wherein R is EMI2.2 R1 is hydrogen or methyl. when tested for hypoglycemic effect in rats (oral doses of 25 mg/100 g), the compounds in which R is butyl and phenyl were most potent. The others were of ;w potency or inactive. Wojciechowski, J. Acta. Polon. Pharm. 19, p. 121-5 (1962) Them. Ab., 59 1633 e] describes the synthesis of N-[(2,6-dimethoxypyrimidin-4-yl)aminocar bonyl]-4-methylbenzenesulfonamide: EMI2.3 U.S. Patent 4,127,405 teaches compounds which are useful for controlling weeds in wheat having the formula EMI3.1 wherein EMI3.2 R1 is EMI3.3 R3 and R6 are independently hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, nitro, trifluoromethyl, cyano, CH3S(0) n or CH3cH25(0)n ; R4 is hydrogen, fluorine, chlorine, bromine or methyl; R5 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy; R7 is hydrogen, fluorine, chlorine, bromine, alkyl of 1-2 carbon atoms or alkoxy of 1-2 carbon atom; ; R8 is hydrogen, methyl, chlorine or bromine; Rg and Rlo are independently hydrogen, methyl, chlorine or bromine; W and Q are independently oxygen or sulfur; n is 0, 1 or 2; X is hydrogen, chlorine, bromine, methyl, ethyl, alkoxy of 1-3 carbon atoms, trifluoro methyl, CH3S- or CH3 0 CH2-; and Z is methyl or methoxy; or their agriculturally suitable salts; provided that: (a) when R5 is other than hydrogen, at least one of R3, R4, R6 and R7 is other than hydrogen and at least two of R3, R4, R6 and R7 must be hydrogen; (b) when R5 is hydrogen and all of R3, R4, R6 and R7 are other than hydrogen, then all of R3, R4, R6 and R7 must be either chlorine or methyl; and (c) when R3 and R7 are both hydro gen, at least one of R4, R5 or R6 must be hydrogen. In addition, U.S. Serial No. 227,886 teaches o-alkylsulfonylbenzenesulfonylureas which are useful as herbicides. In U.S. Serial No. 274,233, there is a disclosure of herbicidal benzotb]thiophene- and benzofuransulfonylureas in which the sulfonylureido group is bonded to the heterocyclic ring. In U.S. Serial No. 363,379, there is a disclosure of herbicidal benzodioxole- and benzodioxansulfonylureas, while in U.S. Serial No. 312,183, herbicidal benzofuran- and benzothiophenesulfonylureas are disclosed in which thiosulfonylureido group is bonded to the benzo ring. The presence of undesired vegetation causes substantial damage to useful crops, especially agricultural products that satisfy man's basic food and fiber needs, such as cotton, rice, corn, wheat, and the like. The current population explosion and concomitant world food and fiber shortage demand improvements in the efficiency of producing these crops. Prevention or minimizing the loss of a portion of such valuable crops by killing, or inhibiting the growth of undesired vegetation is one way of improving this efficiency. A wide variety of materials useful for killing, or inhibiting (controlling) the growth of undesired vegetation is available; such materials are commonly referred to as herbicides. The need still exists however, for more effective herbicides. Summary of the Invention This invention relates to compounds of Formula I, agricultural compositions containing them and their method-of-use as general or selective pre-emergent or post-emergent herbicides or plant growth regulants. EMI6.1 wherein J is EMI6.2 and Q is O, S or S02; R is H or CH3; R1 is H, CH3, OCH3, C1, Br, C02R5, S02R6, OS02R7 or SO2NR8R9; R2 and R3 are independently H or C1-C3 alkyl; R4 is H or CH3; R5 is C1-C3 alkyl, CH2CH=CH2, CH2CH20CH3 or CH2CH2C1; R6 is C1-C3 alkyl; R7 is C1-C3 alkyl or CF3; R8 and R9 are independently C1-C2 alkyl; A is EMI7.1 G is O or CH2; X is CH3, OCH3 or C1; X1 is CH3, OCH3 or OC2H5; Y is CH3, OCH3, OC2H5, CH2OCH3, C2H5, NH2, NHCH3 or N(CH3)2; Z is CH or N; and their agriculturally suitable salts provided that 1) when X is C1, then Z is CH and Y is OCH3, NH2, NHCH3, N (CH3)2 or OC2H5; 2) the total number of carbon atoms in R2 and R3 are less than or equal to 3; 3) In Structure J2 when R2 and R3 is other than H, then R4 is H; 4) In Structure J3 when R2 is other than H, then R4 is H; 5) when Q is S, then R1 is not 502NR8Rg; 6) In Structures J3 and J6, Q may not be O; and 7) In Formula J7, R1 is not CH3. Preferred for reasons of their higher herbicidal activity, greater plant growth regulant activity, or more favorable ease of synthesis are: 1) Compounds of Formula I where J is J1 2) Compounds of Preferred 1 where R is H 3) Compounds of Preferred 2 where R1 is H 4) Compounds of Preferred 3 where A is EMI8.1 and X is OCH3 or C1 5) Compounds of Preferred 4 where Y is CH3 or OCH3 6) Compounds of Formula I where J is J2 7) Compounds of Preferred 6 where R is H 8) Compounds of Preferred 7 where R1 is H 9) Compounds of Preferred 8 where EMI9.1 and X is OCH3 or Cl 10) Compounds of Preferred 9 where Y is CH3 or OCH3 11) Compounds of Formula I where J is J3 12) Compounds of Preferred 11 where R is H 13) Compounds of Preferred 12 where R1 is H 14) Compounds of Preferred 13 where EMI9.2 and X is OCH3 or Cl 15) Compounds of Preferred 14 where Y is CH3 or OCH3 16) Compounds of Formula I where J is J4 17) Compounds of Preferred 16 where R is H 18) Compounds of Preferred 17 where R1 is H 19) Compounds of Preferred 18 where EMI9.3 and X is OCH3 or Cl 20) Compounds of Preferred 19 where V is CH3 or OCH3 21) Compounds of Formula I where J is J5 22) Compounds of Preferred 21 where R is H 23) Compounds of Preferred 22 where R1 is H 24) Compounds of Preferred 23 where EMI10.1 and X is OCH3 or C1 25) Compounds of Preferred 24 where Y is CH3 or OCH3 26) Compounds of Formula I where J is J6 27) Compounds of Preferred 26 where R is H 28) Compounds of Preferred 27 where R1 is H 29) Compounds of Preferred 28 where EMI10.2 and X is OCH3 or C1 30) Compounds of Preferred 29 where Y is CH3 or OCH3 31) Compounds of Formula I where J is J7 32) Compounds of Preferred 31 where R is H 33) Compounds of Preferred 32 where R1 is H 34) Compounds of Preferred 33 where A is EMI11.1 and X is OCH3 or C1 35) Compounds of Preferred 34 where V is CH3 or OCH3 Specifically preferred for reasons of their highest herbicidal activity, greatest plant growth regulant activity and/or ease of synthesis are: N-E(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]- 3, 4-dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1 dioxide; # N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3,4 dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1 dioxide; and # N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocar bonyl]-3,4-dihydro-2H-1-benzothiopyran-8-sulfon amide, l,l-dioxide. This invention also relates to compounds of Formula I', suitable agricultural compositions containing them, and their use as pre-emergence and/or post-emergence herbicides EMI12.1 I' wherein J' is EMI12.2 J'1 J'2 J'3 and Q is O, S or 502; 1 is O, S, SO or SO2; R is H or CH3; R'1 is H, CH3, OCH3, C1, Br, NO2, C02R5, SO2R6, OS02R7 or 502NR8Rg; 2 is H or C1 C3 alkyl; R3 is H or CH3; R4 is H or CH3; R4 is H, C1, CH3, CF3, OCH3 or Br; R5 is C1-C3 alkyl, CH2CH=CH2, CH2CH2OCH3 or CH2CH2Cl; R6 is C1-C3 alkyl; R7 is C1-C3 alkyl or CF3; R8 and R9 are independently C1-C2 alkyl; R10 is H, C1, Br or C1-C3 alkyl; R11 is H, CH3, Cl or Br; W is O or S; A' is EMI13.1 G is O or CH2; ; X' is H, CH3, OCH3 or C1; X1 is CH3, OCH3 or OC2H5; X2 is CH3, C2H5 or CH2CF3; Yê is CH3, OCH3, OC2H5, CH2OCH3, NH2, NHCH3, N(CH3)2, CH(OCH3)2, EMI13.2 C2H5, CF3, CH2=CHCH2O, SCH3, HC#CCH2O or CH3CH2O; Y2 is C2H5, CH3, OCH3, OC2H5, SCH3, or SC2H5; and Z' is CH, N, CCH3, CC2H5, CCl or CBr; and their agriculturally suitable salts provided that 1) In Structures Ji and J2', when Q1 is O and R'1 is other than H, C1, Br or N02, then at least one of R2 and R3 is alkyl, and when Q1 is S, then Rj cannot be NO2; 2) In Structure J3, when R'1 is N02 or SO2NR8R9, then R10 is C1-C3 alkyl and R11 is CH3; 3) when X' is C1, then Z' is CH and Y' is OCH3, NH2, NHCH3 or N(CH3)2; 4) when Q1 is SO, then W is 0; and 5) when R4 is other than H, then R1 is H. Preferred for reasons of their higher herbicidal activity or more favorable ease of synthesis are: 1) Compounds of the generic scope of Formula I' where J' is J'1 and R4 is H. 2) Compounds of Preferred 1 where W is O and R is H. 3) Compounds of Preferred 2 where R'1 is H, C1, CH3, OCH3, C02R5 or SO2R6. 4) Compounds of Preferred 3 where R4 and Ri are H and R2 and R3 are independently H or CH3. 5) Compounds of Preferred 4 where A' is EMI14.1 Z' is CH or N; and X' is CH31 OCH3 or Cl. 6) Compounds of Preferred 5 where Y' is CH3, OCH3, CH20CH3 or N(CH3)2. 7) Compounds of the generic scope of Formula I where J' is J2. 8) Compounds of Preferred 7 where W is O and R is H. 9) Compounds of Preferred 8 where R'1 is H, C1, CH3, OCH3, CO2R5 or SO2R6. 10) Compounds of Preferred 9 where R'1 is H and R2 and R3 are independently H or CH3. 11) Compounds of Preferred 10 where A' is EMI15.1 is CH or N; and X' is CH3, OCH3 or C1. 12) Compounds of Preferred 11 where Y' is CH3, OCH3, CH2OCH3 or N(CH3)2. 13) Compounds of the generic scope of Formula I' where J' is J3'. 14) Compounds of Preferred 13 where W is O and R is H. 15) Compounds of Preferred 14 where R11 is is H, and R'1 is H, C1, CH3, OCH3, CO2R5 or SO2R6 and where SO2NHC(W)NRA' is bonded to the 7-position. 16) Compounds of Preferred 15 where R'1 is H and R10 is H or CH3. 17) Compounds of Preferred 16 where A' is EMI15.2 is CH or N; and X' is CH3, OCH3 or C1. 18) Compounds of Preferred 17 where V' is CH3, OCH3, CH2OCH3 or N(CH3)2. This invention also relates to compounds of Formula I" which are useful intermediates for the preparation of the herbicidal compounds of Formula I' EMI16.1 I" where Q1 is 0, S or S02; R2 is H or C1-C3 alkyl; R3 is H or CH3; and R4 is H or CH3. Specifically preferred for reasons of their highest herbicidal activity, greatest plant growth regulant activity and/or ease of synthesis are: # N-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2,3 dihydro-2-methyl-7-benzothiophenesulfonamide, 1,1-dioxide; # N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl] 2,3-dihydro-2-methyl-7-benzothiophenesulphonamide, 1,1-dioxide; # N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2,3 dihydro-2-methyl-7-benzothiophenesulfonamide, 1,1-dioxide; # N-[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]- 2,3-dihydro-2-methyl-7-benzothiophenesulfonamide, 1,1-dioxide; # N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino carbonyl]-2,3-dihydro-2-methyl-7-benzothiophene sulfonamide, 1,1-dioxide; ; # N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl] 2-methylamino-2-methyl-7-benzothiophene-@@dioxide, 1,1-dioxide; # 2,3-dihydro-N-[(4-methoxy-6-methylpyrimidin-2-yl) aminocarbonyl]-2-methylbenzofuran-7-sulfonamide; # N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-2,3 dihydro-2-methylbenzofuran-7-sulfonamide; # N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2,3 dihydrobenzo[b]thiophene-7-sulfonamide, 1,1-dioxide; and # 2,3-Dihydro-N-[(4-methoxy-6-methylpyrimidin-2-yl) aminocarbonyl]benzo[b]thiophene-7-sulfonamide, 1,1 dioxide. Detailed Description of the Invention Synthesis The compounds of Formulae (I) and (I') can be prepared by methods described below in Equations 1, 2 and 3. As shown in Equation la, compounds of Formula (I) can be prepared by reacting a sulfonylcarbamate of Formula (II) with an appropriate amine of Formula (III). J, R and A are as previously defined. Equation la EMI18.1 Similarly, as shown in Equation lb, compounds of Formula (I') (where W=O) can be prepared by reacting a sulfonylcarbamate of Formula (II') with an appropriate amine of Formula (III'). J', R and A' are as previously defined. Equation ib EMI18.2 The reactions are carried out at 50-100 C in a solvent such as dioxane for 1/2 to 24 hours as taught in EP-A-0044807. The required carbamates (11) or (II') are prepared by reacting the corresponding sulfonamides (IV) or (IV'), respectively, with diphenylcarbonate in the presence of a strong base. Alternatively, as shown in Equation 2a, compounds (I), where R1 is other than C02R5, can be prepared by reacting sulfonamides of Formula (IV) with an appro priate methylcarbamate of Formula (V) in the presence of an equimolar amount of trimethylaluminum. Equation 2a EMI19.1 Similarly, as shown in Equation 2b, compounds I', where Rj is other than C02R5 and W=O, can be prepared. EMI19.2 The reactions of Equations 2a and 2b are carried out at 250 to400C in a solvent such as methylene chloride for 10 to 96 hours under an inert atmosphere The reaction of equation 3a and 2b is best run in methylene chloride at about 250 to 400 C for 10 to 96 hours under a nitrogen atmosphere. The products can be isolated by addition of an aqueous acetic acid solution followed by extraction of the products into methylene chloride, or by filtration of a product of low solubility. The products can be purified by trituration with solvents such as l-chlorobutane, ethyl acetate or ethyl ether or by column chromatography on silica gel. The compounds of Formula (I) where J is J1' J4 and J7 for all values of Q and J2, J3, J5 and J6 when Q is S02 can be prepared by reacting sulfonylisocyanates of Formula (VI) with an appropriate amine of Formula (III) as shown in Equation 3a. Equation 3a J-S02N=C=O + III VI EMI20.1 I Similarly, compounds of Formula (I') can be prepared as shown in Equation 3b. Equation 3b J'-SO2N=C=W + III' EMI20.2 I' VI' The reactions of Equations 3a and 3b are carried out at 250 to 400C in an inert aprotic solvent such as methylene chloride for 0.5 to 24 hours as taught in U.S. Patent 4,127,405. The intermediate sulfonylisocyanates (VI) or (VI') (W=O), can be prepared from the appropriate sulfonamides (IV) or (IV'), respectively, by the reaction with phosgene, in the presence n-butylisocyanate and a tertiary amine catalyst, at reflux in a solvent such as xylene by the method of U.S. Patent 4,238,621. Alternatively, the sulfonylisocyanates can be prepared from the sulfonamides by a two step procedure involving (a) reacting the sulfonamides with n-butylisocyanate in the presence of a base such as K2COD at reflux in an inert solvent such as 2-butanone forming a n-butylsulfonylurea; and (b) reacting this compound with phosgene and a tertiary amine catalyst at reflux in xylene solvent. The method is similar to a procedure taught by Ulrich and Sayigh, Newer Methods of Preparative Organic Chemistry, Vol. VI, p. 223-241, Academic Press, New York and London, W. Foerst Ed. The intermediate sulfonylisothiocyanates of Formula VI' (W=S) in Equation 3b can be prepared from sulfonamides by methods taught in H. Hartke, Arch. Pharm., 229, 174 (1966). The method requires (a) reacting an appropriate sulfonamide with an equivalent amount of carbon sulfide and two equivalents of potassium hydroxide in dimethylformamide at room temperature for 1-8 hours to form the dipotassium salt of the sulfonyliminodithiocarbonate; (b) diluting the suspension with ethyl acetate, ethyl ether or similar aprotic solvent to cause the salt to precipitate, (c) reacting the isolated, dried salt with phosgene in an inert solvent such as xylenes, benzene, carbon tetrachloride or methylene chloride at about room temperature for 1-3 hours; and (d) isolating the sulfonylisothiocyanate, which is usually soluble in the solvent, by filtering off the insoluble potassium chloride and concentrating the filtrate. In place of phosgene, a chloroformic ester (e.g., methyl chloroformate), phosphorus pentachloride, sulfuryl chloride or thionyl chloride may be used. The sulfonylisothiocyanates VI' (w-S) may tend to be unstable and dimerize readily, however, the dimers can be used in the same manner as the parent isothiocyanates for the purposes of this invention. The sulfonamides of Formula IV and IV' in Equations 1, 2 and 3 are important intermediates for the preparation of the compounds of this invention. The synthesis of the required sulfonamide intermediates are described in Equations 4, 5, 6 and 7. As shown in Equation 4a, sulfonamides of Formula IV, where J is J1, J2, J4, J5 and J7 for all Q, can be prepared from the corresponding sulfonyl chlorides of Formula VII. Equation 4a J-NH2 VIII EMI22.1 J-S02Cl VII EMI22.2 Similarly, as shown in Equation 4b, sulfonamides of Formula IV' can be prepared from the corresponding sulfonyl chlorides of Formula VII'. Equation 4b J'-NH2 EMI22.3 J'-SO2Cl VIII' VII EMI22.4 The preparation of sulfonamides from ammonium hydroxide and sulfonyl chlorides is widely reported in the literature, e.g., Crossley et al., J. Am. Chem. Soc., 60, 2223 (1938) and Pailer, Monatsh., 92, 677 (1961). Preparation utilizing the reaction of sulfonyl chlorides with an excess of anhydrous ammonia at OOC in ethyl ether or chlorobutane is also known. The sulfonyl chlorides VII or VII' can be prepared from the appropriate amine VIII or VIII', respectively, by diazotization with sodium nitrite in HC1, followed by reaction of the diazonium salt with sulfur dioxide and cupric chloride in acetic acid analogous to the teachings of Yale and Sowinski, J. Orq. Chem., 25, 1824 (1960). Alternatively, sulfonyl chlorides of Formula VII and VII' can be prepared by a modification of the above procedure whereby the diazotization reaction is carried out in dilute sulfuric acid (20-50%), at 00 to lO0C for 0.2 to 1 hour. The resulting diazonium salt is reacted with sulfur dioxide, HC1 and cuoric chloride in a cosolvent mixture consisting of acetic acid water (1:1) and an immiscible, inert solvent such as l-chlorobutane or methylene chloride at 00-400C for 1 to 24 hours. The mode of addition is not critical; it is however, often convenient to add the diazonium salt to the suspension containing the sulfur dioxide. The sulfonyl chlorides are isolated by addition of water, separation of tne organic phase, washing the organic phase with saturated aqueous NaHC03 and water and evaporation of the solvent under reduced pressure at less than about 5O0C. Sulfonamides of Formula IVa, where n is 1 or 2, are prepared from their corresponding saturated analogs Ivb as shown in Equation 5. R1, R2, and R4 are as previously defined. When n is 2, R4 is H. Equation 5 EMI24.1 The reaction is carried out by contacting the saturated sulfide with one equivalent of a suitable oxidizing agent such as hydrogen peroxide in a solvent such as acetic acid to produce the corresponding sulfoxide. The sulfoxide is then heated with acetic anhydride with or without a cosolvent at 50 to 1400C for 2 to 24 hours. This is similar to the method taught by Parham and Koncos, J. Amer. Chem. Soc., 83, 4034 (1961) for the preparation of 4H-l-benzothiopyran. Sulfonamides of Formula IVc where n is O or 1 can also be prepared from the corresponding saturated analogs Ivd by the two step sequence shown in Equation 6. R1, R2, R3, R4 and 4 are as previously described except that R1 is not CH3. When n is 1, R4 is H. Equation 6 EMI24.2 The first step involves benzyiic bromination by N-bromosuccinimide in refluxing carbon tetrachloride to give a monobromo derivative. The monobromide is dehydrobrominated in the second step by contacting with a suitable base such as DABCO or ethoxide in an inert solvent such as benzene. This method has been used to prepare 2H-l-benzopyran from dihydrobenzopyran (Clemo and Ghatge, J. Chem. Soc., 4347 (1955)). Applying the above procedure a second time to the compounds IVc where n is 1, Q is S02 and R3 is H will provide sulfonamides IV where J is J7, as taught by Traynelis and Love, J. Org. Chem., 26, 2728 (1961). Sulfonamides of Formula IV'a, where J' is Ji and Q is S and Ri and R4 are H, can also be prepared from N-t-butylbenzenesulfonamide as shown in Equation 7. Equation 7 EMI26.1 wherein R2 is C1-C3 alkyl; R3 and R4 are as previously defined; R'2 is H or CH3; and R"2 is H, CH3 or C2H5; when R"2 is C2H5, R2 is H. The reactions of Equation 7(a) are run in-situ as follows: The dilithium salt C is prepared by reacting N-t-butylbenzenesulfonamide with two equivalents of n-butyl lithium at 0 to 300C in an inert solvent such as tetrahydrofuran for one to five hours, according to the teachings of Lombardino, J. Org. Chem., 36, 1843 (1971). The N-t-butyl-2-propenylthiobenzenesulfonamide of Formula E is then prepared by (1) contacting this mixture containing C with elemental sulfur at 00 and stirring at ambient temperature for one to five hours to form lithium thiolate D; (2) contacting this mixture with an appropriate allyl halide at û and stirring at ambient temperature for 0.5 to 24 hours to form E; and (3) isolating E by addition of dilute hydrochloric acid to this mixture to decompose any salts present, followed by separation and concentration of the organic phase. The reaction of organolithium reagents with sulfur to form lithium thiolates which may be alkylated in-situ is known in the art, e.g., Gschwend et al., "Organic Reactions", 26, Chapter 1, p. 83 (1979) and references cited therein. In Reaction 7(b) above, the N-t-butyl-2,3-dihy dro-7-benzo[b]thiophenesulfonamides of Formula F are prepared by heating E either neat or in an inert solvent such as quinoline or N,N-dimethylaniline at 150-3000C for 0.25 to 2 hours to cause cyclization. Compound F is isolated by addition of an inert solvent such as ether or methylene chloride, washing well with dilute hydrochloric acid and water, followed by sepa ration and concentration of the organic phase. Compound F can be purified by column chromatography and recrystallization procedures. And in Reaction 7(c), the t-butylsulfonamides F are dealkylated to form sulfonamides VI'a by reacting F with excess trifluoroacetic acid at 200 to 400C for about 10 to 30 hours. Compounds VI'a are isolated and purified by concentration of the reaction mixture, addition of methylene chloride to the residue, washing the suspension with dilute aqueous NaHC03 and concentration of the organic phase. Alternatively, t-butylsulfonamides F may be converted to sulfonamides VI'a by heating in methanol containing at least an equimolar quantity of hydrochloric acid, followed by concentration of the reaction mixture and precipitation of the product with ether. Finally, sulfonamides of Formula IV where Q is SO2 can be prepared from the appropriate sulfonamides IV where Q is S by a variety of standard literature procedures with m-chloroperbenzoic acid (Johnson et. al., Tetrahedron 25, 5649 (1969), or with aqueous hydrogen peroxide in acetic acid (Bordwell et. al., J. Amer. Chem. Soc., 77, 1141 (1955)). The amines of Formula VIII in Equation 4a, where J is J12 J2' J4, J5 and J7 for all Q, can be prepared by reduction of the corresponding nitro compounds of Formula IX, as shown in Equation 8. Equation 8 J-Nû2 IX EMI28.1 VIII The reduction of nitro compounds to amines can be carried out by any of several known methods as described in Preparative Orqanic Chemistry, 4 Ed., p. 557-563, John Wiley and Sons, New York and London, G. Hilgetag and A. Martini Ed. Alternatively, the amines of Formula Villa can be prepared by a thioClaisen rearrangement of an appropriate allyl phenylthio ether X as outlined in Equation 9. R1, R2, R3 and R4 are as previously defined. Equation 9 EMI29.1 The rearrangements are carried out at 1800 to 2500C for 0.5 to 24 hours either neat or in the presence of a high boiling amine solvent such as quinoline or diethylaniline as taught by S. J. Rhoads and N. R. Raulins, Organic Reactions, Vol. 22, p. 1-252, John Wiley and Sons, New York and London, W. G. Dauben, Editor in Chief. The 6ring fused product Villa is accompanied by a 5-ring fused isomer (see Equation 23) and the desired amine VIIIa can be separated by either fractional crystallization, fractional distillation or by a chromatographic method. The starting allylphenylthio ethers X can be prepared from the appropriate aminothiophenols by methods known to one skilled in the art. The preparation of the nitro compounds of Formula IX in Equation 8 where J is either J1 and J4 or J2 and J5 and R1 is H, CH3, OCH3, C1 or Br is outlined in Equation 10. The two routes utilize a common nitro ketone intermediate XI; R2, R3, R4 and Q are as previously defined and n is O or 1; when n is 1, R4 is H. Equation 10 EMI30.1 The saturated nitro compounds of Formula IXa are prepared by selectively reducing the tosylhydrazone derivative of nitro ketone XI with catecholborane in a solvent such as chloroform for 2 to 24 hours at ambient temperatures according to the teachings of Kabalka and Chandler, Synthetic Commun., 9, 275 (1979). Alternatively, ketone XI can be reduced directly to give the corresponding alcohol which is then dehydrated by one of a variety of known methods such as P205 by one skilled in the art. The nitro compounds of Formula IX in Equation 8 where J is J1 and J4 and R1 is C02R5, S02R6, OS02R7 or 502NR8Rg are prepared from the corresponding compounds IXc (from Equation 10, compounds IXa where R1 is C1) as shown in Equation 11. R2, R3 and R4 are as previously defined, Q is O or S and n is O or 1; when n is 1, and R4 is H. Equation 11 EMI31.1 As shown in Equation 11, the chloronitro compounds IXc are contacted with a reagent or reagents, to be discussed below, to form compounds IXa containing the desired R1 group. The nitro compounds of Formula IXa where R1 is S02R6 are prepared in one step by reacting IXc with an appropriate sulfinic acid salt in a solvent such as dimethylformamide at 250 to 800C for 1 to 24 hours. Such displacements are reviewed in Orqanic Chemistry of Sulfur, p. 536-539, Plenum Press, New York and London, 1977, 5. Oae, Ed. Alternatively, IXc can be reacted with an appropriate thiol in the presence of a suitable base such as sodium hydride or potassium hydroxide under the conditions described above to give an intermediate sulfide of Formula IXa where R1 is SR6. The sulfide is then oxidized to the desired compounds IXa where R1 is S02R8 and Q is O or 502 by methods known to one skilled in the art. The nitro compounds of Formula IXa where R1 is S02NR8Rg and Q is O or S02 are prepared in two steps starting from an intermediate sulfide (IXa where R1 is SR6) prepared as described above. The sulfide is reacted with molecular chlorine in aqueous acetic acid at 100 to 500C for 0.5 to 4 hours to give the corresponding sulfonyl chloride IXa where R1 is S02C1 as taught by Langler, Can. J. Chem., 54, 498 (1976) and Langler and Grossert, Can. J. Chem., 55, 407 (1977). The sulfonyl chloride is then contacted with an excess of an appropriate dialkyl amine in an inert solvent such as tetrahydrofuran by methods known to one skilled in the art. The nitro compounds of Formula IXa where R1 is OS02R7 can be prepared in two steps by first heating IXc with one equivalent of a strong base such as sodium or potassium hydroxide in dimethylformamide at 250 to 800C for 1 to 8 hours to form an intermediate compound IXa where R1 is OH. This intermediate is reacted with an appropriate sulfonyl chloride R8S02C1 or the appropriate anhydride in the presence of a base such as triethyl amine in an inert solvent such as methylene chloride at 0 to 400C for 1 to 24 hours. The nitro compounds of Formula IXa where R1 is C02R5 can be prepared in three steps by first reacting IXc with one equivalent of potassium cyanide in dimethylformamide at 250 to 800C for 1 to 8 hours to form an intermediate compound IXa where R1 is CN. This intermediate can be hydrolized by heating in a strong acid such as HC1 in a solvent such as acetic acid to form a carboxylic acid which can then be converted to its corresponding esters by methods known to one skilled in the art. The nitro compounds of Formula IX in Equation 8 where J is J2 and J5 (Formula IXb in Equation 10) and R1 is C02R5, S02R6, OS02R7 or S02NR8R9 are prepared from the corresponding saturated analogs IXa by the bromination/dehydrobromination sequence described earlier for sulfonamides IVc in Equation 6. This procedure can also be used to prepare compounds of Formula IXb where R1 is H, OCH3, C1 or Br. When this procedure is applied a second time to compounds IXb where n is 1, Q is S02 and R3 and R4 are H, the nitro compounds of Formula IX where J is J7 are obtained. Finally, the nitro compounds of Formula IX in Equation 8 where Q is S02 can be prepared from the corresponding nitro compound IX where Q is S by methods discussed earlier for sulfonamides IV. Several of the nitro compounds of Formula IX are known, for example 8-nitro-3,4-dihydro-2H-l-benzopyran (Bowie and Chai, Aust. J. Chem., 30, 675 (1977)), and 8-nitro-2H-l-benzopyran (Box and McCaw, Rev. Latinoam. Quim, 10, 118, (1979)). The nitro ketones of Formula XI in Equation 10 where R1 is H, CH3, OCH3, C1 or Br are prepared by cyclization of the appropriate carboxylic acid XII as shown in Equation 12. R2, R3 and R4 are as previously defined, Q is O or S and n is O or 1, when n is 1, R4 is H. Equation 12 EMI33.1 The reaction is carried out by heating the acid with a suitable condensing agent such as polyphosphoric acid, hydrofluoric acid, sulfuric acid or stannic chloride or the acid may be converted to its chloride and heated with a typical Friedel-Crafts reagent such as aluminum chloride or stannic chloride. For a comprehensive review of this and related reactions, see "Friedel-Crafts and Related Reactions" Vols. 1-4, Interscience, New York and London, G. A. Olah, Ed. In cases where R2 does not equal R3, and R4 is other than H, isomeric mixtures may result. These mixtures can be used in subsequent reactions or separated by fractional crystallization or chromatographic methods. The starting nitro carboxylic acids XII can be prepared by reacting an appropriate nitrophenol or nitrothiophenol with the appropriate B-bromopropionate or t-bromobutyrate in the presence of base by methods known to one skilled in the art. The preparation of benzopyrans, benzothiopyrans, benzoxepin and benzothiepin from substituted phenols and thiophenols are widely reported in the literature. For general reviews see "Chromans and Tocopherols", The Chemistry of Heterocyclic Compounds, Vol. 36, John Wiley and Sons, New York, 1981, G. P. Ellis, Ed.; "Chromenes, Chromanones and Chromones", The Chemistry of Heterocyclic Compounds, Vol. 31, John Wiley and Sons, New York, 1977, G. P. Ellis, Ed.; "Seven-Membered Heterocyclic Compounds Containing Oxygen and Sulfur", The Chemistry of Heterocylic Compounds, Vol. 26, John Wiley and Sons, New York, 1972, A. Rosowsky, Ed.; "Polycyclic Five- and Six-Membered Compounds Containing One O or S Atom", Heterocylic Compounds, Vol. 2, John Wiley and Sons, New York, 1951, R. C. Elderfield, Ed. For a most recent review on the Synthesis and Reactions of 4-Chromanones, see: Kabbe and Widdig, Angew Chem. Int. Ed. Engl., 21, 247 (1982). The amines of Formula (VIII') in Equation 4b above are also important starting materials for the preparation of the compounds of this invention, which can be prepared by the following general methods. Several of the starting 4- and 7-amino-2,3-dihydrobenzofurans of Formula (VIII') in Equation 4b are known. For instance, 4-amino-2,3-dihydro-2,2-dimethylbenzofuran may be prepared by the procedure of Cruickshank et al., J. Med. Chem., 13, 1110 (1970); 7-amino-2,3-dihydro-2,2-dimethylbenzofuran by the procedure of Netherlands 6,602,601; 7-amino-2,3-dihydro2-methylbenzofuran by the procedure of BE-A744,858; 4-amino-2,3-dihydrobenzofuran by the procedure of U.S. 3,963,717; and 7-amino-2,3-dihydrobenzofuran by the procedure of U.S. 3,963,717. The 7-amino-2,3-dihydrobenzofurans of Formula (VIII') in Equation 4b, where Ri is H, CH3, OCH3, C1 or Br, can be prepared by a procedure analogous to that taught in NL-A-6,602,601. This procedure is illustrated in Equation 13 below. Equation 13 EMI35.1 EMI36.1 wherein R1 is H, CH3, OCH3, C1 or Br; R2 is C1-C3 alkyl; R3, R4 and R4 are as previously defined; R2, is H or CH3; and R2 is H, CH3 or C2H5; when R2 is C2H5; R2, is H. As shown in Equation 13, the preparation requires three steps: (1) reacting a 3- or 4-(substituted)-2-nitrophenol with an appropriately substituted allyl chloride to form intermediate G; (2) heating this compound at elevated temperatures 1500 to 300 C with a catalyst to cause cyclization to form H; and (3) reducing this compound to form VIII'a. The first reaction is run in a warm protic solvent such as ethanol in the presence of a weak base such as K2C03. The cyclization step is normally run neat at elevated temperatures, in the range of 150 to 3000C for 1 to 24 hours. A Friedel-Crafts catalyst, such as magnesium chloride, is ordinarily used to promote the cyclization reaction and increase product yields. Intermediate H may be purified by recrystallization or chromatography procedures. The reduction step can be carried out by any of several known methods for reducing nitro groups to amino groups. For example, intermediate H can be catalytically reduced with 5% palladiumon-charcoal in ethanol solvent at about 250 to 450C and at 1 to 3 atmospheres of pressure. Alternatively, H can be heated with stannous chloride in concentrated hydrochloric acid at about 250 to 800C for 0.5 to 3 hours to form VIII'a. Alternatively, the Claisen rearrangement-cyclization reaction in Equation l3b above can be run stepwise as follows: (a) phenyl allyl ether G can be rearranged at about 1500 to 2000C for 0.5 to 10 hours either neat or in the presence of a suitable high boiling solvent such as diethylaniline to yield the corresponding 4- or 5-(substituted)-6-nitro-2-allylphenol, according to the teachings in S. J. Rhoads and N. R. Raulins, Organic Reactions, Vol. 22, p. 1-253, John Wiley and Sons, New York and London, W. G. Dauben, Ed.; and (b) this compound may be cyclized to dihydrobenzofuran H by methods widely reported in the literature for analogous type reactions. For instance, heating the rearranged product with pyrimidine.HCl (R4 and R5 are not OCH3), or with acidic reagents such as hydrogen bromide in acetic acid, or with a Friedel Crafts catalyst such as magnesium chloride can yield H according to teachings of Claisen and Tietze, Ann, 449, 81 (1926), and 442, 235 (1925); Arnold and Mc Cool, J. Am. Chem. Soc., 64, 1315 (1942); J. Entel et al., ibid., 73, 2365 (1951); P. Cruickshank et al., J. Med. Chem., 13, 1110 (1970); and Q. Bartz et al., J. Am. Chem. Soc., 57, 371 (1935). The 7-amino-2,3-dihydrobenzofurans of Formula (VIII') in Equation 4b, where R'1 is OS02R7, 502R6 or C02R5, can be prepared as shown in Equation 14 below. Equation 14 EMI38.1 wherein R2 is C1-C3 alkyl; R3 and R4 are as originally defined; and Ri is OS02R7, S02R6 or C02R5. According to Equation 14, a 6-chloro-7-nitro-2,3dihydrobenzofuran of Formula (XIII) is reacted with reagents as discussed below to form intermediate I containing the desired R1 group. The nitro compound I is then reduced to form VIII'b. These reactions can be run by obvious methods by one skilled in the art. Intermediate (I), where R1 is OS02CH3 for example, is prepared in two steps: (1) heating XIII with one equivalent of a strong base such as sodium or potassium hydroxide in dimethylformamide at 500 to 800C, for 1 to 8 hours, to form (I), where R1 is OH; and (2) reacting the resulting phenol with methanesulfonyl chloride, in the presence of a base such as triethylamine, in an inert solvent such as tetrahydrofuran, at 250 to 700C, for 1 to 24 hours, to form (I) where R is 0S02CH3. Intermediate (I), where R1 is SO2CH3 for example, is also prepared in two steps: (1) heating XIII with one equivalent of sodium methylmercaptide in dimethylformamide at 250 to 800, for 1 to 8 hours, to form (I), where R1 is SCH3; and (2) oxidizing the resulting compound with 30% hydrogen peroxide in acetic acid solvent, at O to 600, for 1 to 8 hours, to form (I), where R1 is S02CH3. Intermediate (I), where R1 is C 02CH3 for example, is prepared in three steps: (1) reacting XIII with one equivalent of potassium cyanide in dimethylformamide at 500 to 800C, for 1 to 24 hours, to form (I) where R1 is CN; (2) hydrolyzing the cyano group to a carboxylic acid by any of several methods known in the art; for example, (I) where R1 is CN can be refluxed with concentrated hydrochloric acid in acetic acid solvent to form (I) where R1 is C O2H; and (3) converting the carboxylic acid to a carbonyl chloride which is then reacted with methanol to form (I) where R1 is C02CH3. The latter reactions can be run by known methods by one skilled in the art. In the final step of Equation 14, (I) can be reduced to VIII'b by methods previously described in Equation 13. The starting 6-chloro-7-nitro-2,3-dihydrobenzofurans of Formula (XIII) are also prepared by methods described above in Equation 13. Similarly, the 4-amino-2,3-dihydrobenzofurans of Formula (VIII') in Equation 4b, where R1 is S02R6, 0502R7 or C02R5, R2 is C1-C3 alkyl, and R3 and R are as originally defined, can be prepared by procedures described in Equation 14. Thus, by starting with an appropriate 5-chloro-4-nitro-2 , 3-dihydrobenzo- furan, and proceeding with the reactions described above in Equation 14, one skilled in the art can prepare the subject 4-amino-2,3-dihydrobenzofurans of Formula (VIII'). The starting 5-chloro-4-nitro-2,3dihydrobenzofurans are described below in Equation 16. The 7-amino-2,3-dihydrobenzofurans of Formula (VIII') in Equation 4b, where R1 is N02 or S02NR8Rg, can be prepared as shown in Equation 15. Equation 15 EMI40.1 wherein R2, R3 and R4 are as originally defined; and Rj is N02 or 502NR8Rg. According to Equation 15, a 7-acetamido-2,3dihydrobenzofuran XIV is reacted with reagents as described below to form intermediate 3. Then J is deacetylated to form VIII'c. Intermediate J, where R, is N02, is prepared in two steps: (1) nitration of XIV with nitric acid in acetic acid solvent, at about 100 to 250C, for 0.5 to 5 hours, to form a mixture containing in part J where R1 is NO2; and (2) separation of J from the mixture by recrystallization or chromatographic procedures. Intermediate J, where R1 is SO2NR8R9, is prepared in three steps: (1) chlorosulfonating XIV with chlorosulfonic acid to form a mixture of products containing in part J, where R1 is S02C1; (2) reacting the resulting mixture with an appropriate dialkylamine in an inert solvent such as tetrahydrofuran, at about 10 to 600C, for 0.5 to 10 hours to form in part J where R1 is SO2NR8R9; and (3) separating out the desired intermediate J by recrystallization or chromatographic procedures. The chlorosulfonation step can be run by reacting XIV with excess chlorosulfonic acid, i.e., about a three equivalent excess, at 250 to 700C, in an inert solvent such as chloroform, for 0.5 to 8 hours. Deacetylation of J to form VIII'c, can be carried out by saponification or acid hydrolysis procedures. Thus, refluxing J in 90% ethanol with one equivalent of sodium hydroxide, for 0.25 to 3 hours, can provide VIII'c. Alternatively, heating J, at 50 to 800C, with hydrochloric acid in acetic acid for 0.5 to 3 hours can also provide VIII'c. The starting compound XIV can be prepared by known methods, i.e., by heating, at 50 to 100 C, an appropriate 7-amino-2,3dihydrobenzofuran in acetic anhydride, with a catalytic amount of sulfuric acid, for 1 to 10 hours. Similarly, the 4-amino-2,3-dihydrobenzufurans of Formula (VIII') in Equation 4b, where R1 is NO2 or S02NR8R9, can be prepared by procedures described in Equation 15 above. Thus, by starting with an appropriate 4-acetamido-2,3-dihydrobenzofuran, and proceeding with the appropriate reactions described above in Equation 15, the following compounds can be prepared: 4-amino-2,3-dihydro-5-nitrobenzofurans and 4-amino-5-(N,N-dialkylsulfonamido)-2,3-dihydrobenzo- furans of Formula (VIII'), where R2 to R4 are as defined above. The starting 4-acetamido-2,3-dihydrobenzofurans can be prepared from 4-amino-2,3-dihydrobenzofurans by methods also described in Equation 15. The 4-amino-2,3-dihydrobenzofurans of Formula (VIII') in Equation 4b, where R, is H, OCH3, C1, Br, C02R5 or OS02R7, can be prepared as illustrated below in Equation 16. Equation 16 EMI42.1 wherein (VIII'd) R2 is C1- C3 alkyl; R3 and R4 are as originally defined; and R1 is H, OCH3, C1, Br, C02R5 or 0502R7. According to Equation 16, a 5-amino-2,3-dihydro4-nitrobenzofuran of Formula (XV) is diazotized, then reacted with appropriate reagents to form intermediate K. Reduction of K can then provide VIII'd. The diazonium salt can be prepared with sodium nitrite in dilute sulfuric (20 to 50%) at about 0 to 10 C by methods known in the art, e.g., Arnold and McCool, J. Am. Chem. Soc., 64, 1315 (1942). Intermediate K, where R'1 is as defined above, can be prepared from the diazonium salt by methods also known in the art. Thus, intermediate K, where R; is C1 or Br, can be prepared by heating the diazonium salt with cuprous chloride and hydrochloric acid or with cuprous bromide and hydrobromic acid, according to the Sandmeyer reaction, e.g., Powers, J. Med. Chem., 19, 57 (1976). Intermediate K, where R1 is OCH3, can be prepared in two steps: (1) intermediate K, where R1 is OH, is prepared by refluxing the diazonium salt with copper sulfate solution (50%), a procedure well-known in the art for preparing phenols from diazonium salts, e.g., Arnold and McCool, J. Am. Chem. Soc., 64, 1315 (1942); and (2) the phenol can then be methylated by a variety of known methods to give K where R, is OCH3. For instance, heating the phenol with dimethylsulfate at about 250 to 600C in water in the presence of an equivalent of NaOH, gives K where R1 is OCH3. Intermediate K, where R1 is OS02R7, can be prepared by reacting the phenol described above with an appropriate alkylsulfonyl chloride and a base such as triethylamine in an inert solvent such as tetrahydrofuran at a temperature of about 0 to 600C. Intermediate K, where R1 is C02R5, is prepared in the following manner: (1) intermediate K, where R1 is CN, is prepared by the Sandmeyer reaction. Thus, the diazonium salt is heated with cuprous cyanide according to methods well known in the art, e.g, Hansch and Schmidhalter, J. Org. Chem., 20, 1056 (1955); (2) intermediate K, where R, is CO2H, is then prepared by refluxing the cyano compound, with hydrochloric acid in acetic acid solvent for 1 to 10 hours; and (3) intermediate K, where R1 is C02R5, is prepared by converting the carboxylic acid to a carbonyl chloride which is then reacted with appropriate alcohols to form K,. where R1 is C02R5. Reaction (3), takes place according to methods known in the art. Intermediate K, where R1 is H, is prepared by reacting the diazonium salt with 50% hypophosphorous acid at O to 200C for 1 to 24 hours, according to a procedure of Bordwell and Stange, J. Am. Chem. Soc., 77, 5939 (1955). The final step in Equation 16, the reduction of K to form VIII'd, is carried out by the methods described previously in Equation 14. The starting compounds of Formula (XV) in Equation 16 can be prepared according to the disclosure of Arnold and McCool, J. Am. Chem. Soc., 64, 1315 (1942), the disclosure of which is herein incorporated by reference. Arnold and McCool teach the preparation of 5-amino-2,3-dihydro-2-methyl-4-nitrobenzofuran by a multistep procedure starting with the reaction of 4-hydroxyacetophenone with allylbromide. By reacting 4-hydroxyacetophenone with other appropriately substituted allylbromides, or allyl chlorides, and using the multistep reactions and conditions taught by Arnold and McCool, one skilled in the art can prepare the compounds of Formula (XV) in Equation 16. The 4-amino-2,3-dihydrobenzofurans of Formula (VIII') in Equation 4b, where Rt is CH3, H, C1 or Br, can be prepared by a procedure analogous to that taught in Cruickshank, J. Med. Chem., 13, 1110 (1970). This procedure is illustrated in Equation 17 below. Equation 17 EMI45.1 wherein R2 is C1-C3 alkyl; R3 and R4 are as originally defined; R'1 is H, CH3, C1 or Br; and R2, is H or CH3, R2 is H, CH3 or C2H5; when R"2 is C2H5, R2 is H. According to Equation 17, the preparation requires three steps: (1) reacting a 2-(substituted)-5hydroxybenzacetamide of Formula (XVI) with an appropriately substituted allyl chloride and potassium carbonate at about 250 to 800C in an inert solvent such as acetone to form intermediate L; (2) heating this compound at elevated temperatures, about 1500 to 3000C with a suitable Friedel-Crafts catalyst such as magnesium chloride to cause cyclization to form a 5-(substituted)-4-acetamido-2,3-dihydrobenzofuran; and (3) deacetylating this compound in the usual manner to form VIII'e. These reactions can be run using methods described previously in Equations 13 and 15. Thus, by starting with an appropriate 2-(substituted)-5-hydroxybenzacetamide of Formula (XVI), and using the reactions and conditions described in steps (a) and (b) of Equation 13 and step (b) of Equation 15, one skilled in the art can prepare the compounds of Formula (VIlIte). The 4- and 7-aminobenzofurans of Formula (VIII') in Equation 4b, where R1 is H and R10 and R11 are H or CH3, can be prepared by known methods. Such methods are exemplified by Pene et al., Bull. Soc. Chim. France, 586 (1966); Rodighiero et al., Gazz. Chim. Ital., 91, 90 (1961); Royer et al., Bull. Soc. Chim. France, 1026 (1970); Kawase, Chem. Ind. (London), 687 (1970); Belgium 744,859; Kawase et al., Bull. Chem. Soc. Japan, 44, 749 (1971); Fr. Demande 2,338,041; U.S. 3,577,441; and U.S. 3,452,033. The 7-aminobenzofurans of Formula (VIII') in Equation 4b, where R1 is H, CH3, OCH3, C1, Br, C02R5, S02R6, or 0502R7 can be prepared as shown in Equation 18 below. Equation 18 EMI47.1 wherein R2, R3 and R4 are as originally defined, except at least one of R2 or R3 must be H; R1, is H, OCH3, C1, Br, C02R5, S02R6 or OS02R7; R11 is H or CH3; and R10 is H or C1-C3 alkyl. As shown in Equation 18, the 7-aminobenzofurans of Formula (VIII'f) can be prepared from corresponding 7-nitro-2,3-dihydrobenzofurans of Formula (XVII), where at least one of R2 or R3 is H. The procedure involves a dehydrogenation reaction followed by a reduction reaction. The dehydrogenation reaction may be carried out using a procedure of Geisman, 3. Am. Chem. Soc., 72, 4326 (1950) and Hurd, J. Am. Chem. Soc., 80, 4711 (1958). Thus, compound XVII is dehydrogenated by a twostep sequence: (1) 2,3-dihydrobenzofuran (XVII) is heated at 600 to 800C for 1 to 24 hours with N-bromosuccinimide (NBS) and benzoyl peroxide catalyst in an inert organic solvent such as benzene or carbon tetrachloride thereby brominating the non-aromatic portion of the molecule to form intermediate M; (2) this intermediate is heated with excess N,N-dimethylaniline, [C6H5N(CH3)23, either neat or in an inert aprotic solvent such as toluene for 1 to 24 hours, to cause dehydrobromination to form 7-nitrobenzofuran N. Reduction of N to form 7-aminobenzofuran VIII'f can be carried out by any of several methods known in the art for reducing nitrobenzofurans. For instance, catalytic reduction of N with Raney Nickel catalyst in an inert solvent such as ethanol at about 250 to 700C and 1 to 3 atmospheres of hydrogen can provide VIII'f, according to a procedure of Belgium 744,858. Many of the starting compounds XVII are described above in Equations 13 and 14. Similarly, the 4-aminobenzofurans of Formula (VIII') in Equation 4b, where R1 is H, OCH3, C1, Br, C02R5 OSO2R7 or 502R6 and R10 is H or C1-C3 alkyl and R11 is H or CH3, can be prepared by procedures described in Equation 18. Thus, by starting with an appropriate 5-(substituted)-2,3-dihydro-4-nitrobenzofuran, and proceeding with the reactions described in Equation 18, one skilled in the art can prepare the subject 4-aminobenzofurans of Formula (VIII'). The preparation of many of the starting 5-(substituted)2,3-dihydro-4-nitrobenzofurans is described above, e.g. Equations 14 and 16. The 7-aminobenzofurans of Formula (VIII') in Equation 4b, where R1 is H, CH3, C1, Br, OCH3 or S02R6, can be prepared as shown in Equation 19 below. Equation 19 EMI49.1 (VIII'g) wherein R1 is H, CH3, C1, Br, OCH3 or S02R6; R10 is H or C1-C3 alkyl; and R11 is CH3. According to Equation 19, the preparation requires three steps (1) reacting a 3-(substituted)-2nitrophenol with an a-chloroketone such as chloropropanone for 1 to 8 hours at 30 to 800C in the presence of a base such as K2C03 in an inert solvent such as acetone to form intermediate 0; (2) cyclizing 0 to form a 7-nitrobenzofuran; and (3) reducing this compound to form a 7-aminobenzofuran of Formula (VIII'g). The cyclization step is carried out in polyphosphoric acid at a temperature of about lOOoC for 0.5 to 24 hours. Other methods are known in the art for preparing benzofurans from phenoxypropanones e.g., Fene, Bull. Soc. Chim. France, 586 (1966); Kawase, Chem. Ind. (London), 687 (1970); and Kawase et al., Bull. Chem. Soc. Japan, 44, 749 (1971). The reduction step can be carried out by the methods described in Equation 18 above. Compound VIII'g, where R1 is S02R6, is prepared by (a) oxidizing the intermediate 7-nitrobenzofuran, where R is SR6, with 30% peracetic acid in acetic acid at 0 to 600C to form an intermediate 7-nitrobenzofuran, where R1 is 502R6, and (b) reducing this compound to form VIII'g where R1 is 502R6, by methods described in Equation 18 above. The 7-aminobenzofurans of Formula (VIII') in Equation 4b, where R1 is N02 or S02NR8Rg and R10 is C1-Ca alkyl and R11 is CH3, can be prepared as shown in Equation 20. Equation 20 EMI50.1 The reactions of Equation 20 can be carried out by procedures described previously in Equation 15. Thus, by nitrating or chlorosulfonating an appropriate 7-acetamidobenzofuran XIX according to procedures described in Equation 15, one skilled in the art can prepare the subject compounds VIII'h. Similarly, the 4-aminobenzofurans of Formula (VIII') in Equation 4b, where R1 is N02 or S02NR8Rg, R10 is C1-C3 alkyl and R11 is CH3, can be prepared by procedures described in Equation 20 above. Thus, by starting with an appropriate 4-acetamidobenzofuran, and carrying out the reactions described in Equation 20, one skilled in the art can prepare the subject 4-aminobenzofurans of Formula (VIII'). The 4-aminobenzofurans of Formula (VIII') in Equation 4b, where R1 is CH3, C1, Br or H, can be prepared by a procedure analogous to that taught by Kawase et al., Bull. Chem. Soc. Jap., 749, 44 (1971). This procedure is illustrated in Equation 21 below. Equation 21 EMI51.1 wherein R1 is H, C1, Br or CH3; R11 is CX3; and Rlo is H or C1 C3 alkyl. According to Equation 21, the procedure requires three steps: (1) refluxing an appropriately substituted 4-substituted-3-nitrophenol with an a-chloroketone such as chloropropanone for 1 to 8 hours in the presence of a base, e.g., K2CO3, in a solvent, e.g., acetone, to form intermediate P; (2) cyclizing P to form a 4-nitrobenzofuran; and (3) reducing this compound to form a 4-aminobenzofuran of Formula (VIII'i). The cyclization step can be carried out in polyphosphoric acid at about 80 to 12O0C for 0.5 to 24 hours. The reduction step can be carried out by methods described in Equation 18 above. The 4- and 7-amino-2,3-dihydrobenzoEb)thiophenes of Formula (VIII') in Equation 4b, where R4 and R are H can be prepared by the Bucherer reaction, as shown in Equation 22 below. Equation 22 EMI52.1 wherein R2, R3 and R4 are as originally defined. The reaction of Equation 22 can be carried out using conditions reported in the literature for Bucherer reactions, e.g., Boswell et al., 3. Heterocyclic Chem., 5, 69 (1968). An appropriate 4- or 7-hydroxy-2,3-dihydrobenzotb]thiophene of Formula (XXI) is heated with concentrated ammomium hydroxide, sulfur dioxide and water in an autoclave at about 1400 to 180 C for 10 to 30 hours to provide VIII'j. The starting compounds XXI can be prepared by known methods. Several such methods are exemplified by DE-A-2,252,335; Xilsheimer, J. Agr. Food Chem., 17, 91 (1969); U.S. 4,032,649; and DE-A2,534,857. The 7-Amino-2,3-dihydrobenzo[b]thiophenes of Formula (VIII') in Equation 4b, where R, is H, CH3, OCH3, C1 or Br, can be prepared as shown in Equation 23 below. Equation 23 EMI53.1 wherein R2 is C1-C3 alkyl; R3, R4 and R4 are as originally defined; R1 is H, CH3, OCH3, C1 or Br; and R2, is H or CH3; R2 is H, CH3 or C2H5; when R2 is C2H5, R2, is H. According to Equation 23, the preparation requires two steps: In Step 23(a) a 3- or 4-(substi- tuted)-2-aminothiophenol is reacted with an appropriately substituted allyl chloride, or allyl bromide, to form intermediate Q. The reaction is run in a warm pro tic solvent such as ethanol in the presence of an equimolar amount of a base such as sodium hydroxide for 1 to 10 hours. After dilution with water, the product Q is isolated by extraction with methylene chloride and concentration of the organic phase. Compound Q may be further purified by chromatography procedures. And in step 23(b), Q is heated neat at 2000 to 3000C for about 0.5 to 5 hours to cause cyclization to form (VIII'k). The 5-ring fused product VIII'k is accompanied by a 6-ring isomer (see Equation 9). The desired product VIII'k can be separated and purified by high resolution distillation or chromatography procedures by one skilled in the art. The 7-amino-2,3-dihydrobenzo[b]thiophenes of Formula (VIII') in Equation 4b, where R1 is H, CH3, OCH3, C1 or Br, can be prepared by a procedure analogous to that taught in Singerman, U.S. 4,032,649, the disclosure of which is herein incorporated by reference. The relevant portion of the procedure is illustrated in Equation 24 below. Equation 24 EMI55.1 wherein R2 is C1-C3 alkyl; R3 and R4 are as originally defined; R4 is H; and Ri is H, CH3, OCH3, C1 or Br. U.S. 4,032,649 teaches the preparation of 7-amino-2,3-dihydro-2,2-dimethylbenzo[b)thiophene by a six-step reaction sequence starting with 7-nitro2,3-dihydro-2,2-dimethylbenzofuran. By starting with an appropriate 5- or 6-(substituted)-7-nitro-2,3dihydrobenzofuran of Formula (XXII), and following the six reactions described in U.S. 4,032,649, one skilled in the art can prepare the 5- or 6-(substi tuted)-7-amino-2, 3-dihydrobenzo[b]thiophenes of Formula (VIII'1). The starting compound XXII can be prepared by methods described heretofore in Equation 13. The six-step reaction sequence of Equation 24 involves (a) reacting XXII with potassium tert-butoxide in dimethylsulfoxide at 0 to 60bC for 0.5 to 10 hours to form a 6-nitro-4 or 5-(substituted)-2vinylphenol, (b) reacting this compound with sodium hydride and dimethylthiocarbamoyl chloride in tetrahydrofuran solvent at 0 to 600C for 1 to 10 hours to form a O-[6-nitro-4 or 5-(substituted)-2-vinyl-N,N- dimethylthiocarbamate, (c) heating this compound under nitrogen at 1500 to 2000C for 0.5 to 5 hours to form a S-t6-nitro-4 or 3-(substituted)-2-vinyl)-N,N-dime- thylthiocarbamate, (d) reducing this compound with iron powder in acetic acid at 250 to 900C for 0.5 to 3 hours to form a S-t6-amino-4 or 5-(substituted)-2 vinyli-N,N-dimethylthiocarbamate, (e) reacting this compound with potassium hydroxide in water-methanol solvent at 400 to 800C for 1 to 24 hours to form a 6-amino-4 or 5-(substituted)-2-vinylthiophenol, and (f) cyclizing this compound by heating under nitrogen at 1500 to 2500C for 0.5 to 6 hours to form VIII'1 in Equation 24. The 7-amino-2,3-dihydrobenzo[b]thiophenes of Formula (VIII') in Equation 4b, where R1 is C02R5, 0S02R7 or 502R6, can be prepared as shown in Equation 25 below. Equation 25 EMI56.1 EMI56.2 wherein R2 is C1-C3 alkyl; R3 is as originally defined; R4 is H; and R1 is C02R5, 0502R7 or S02R6. According to Equation 25, a 6-chloro(or bromo-) 7-nitro-2,3-dihydrobenzoEb)thiophene R is reacted with reagents described below to form intermediate S containing the desired R1 group. The nitro- compound S is then reduced to form VIII'm. These reactions can be run by obvious methods. Thus, compound S, where R1 is OS02R7 or C02R5, can be prepared by one skilled in the art using procedures similar to those described above in Equation 14 for preparing I, where R1 is 0S02R7 or C02R5. Compound S, where R1 is SO 2R6, is prepared by reacting R with an appropriate sulfinate salt, i.e., KS02R6, in an inert solvent such as dimethylformamide at about 400 to 100C for 1 to 8 hours. Nitro compound S is reduced to amine VIII'm with iron powder and acetic acid in ethanol solvent at about 50 to 800C for 1 to 5 hours. The starting compound R may be prepared by analogous procedures described above in Equation 24 and in U.S. 4,032,649 by one skilled in the art. Thus, an appropriate S-[6-nitro-5-chloro(or bromo) 2-vinyl]-N,N-dimethylthiocarbamate may be reacted with potassium hydroxide to form the corresponding 6-nitro5-chloro(or bromo)-2-vinylthiophenol. This compound may then be heated at elevated temperatures, i.e., 1500 to 2500C, to cause cyclization to form a mixture containing R and the corresponding 7-chloro(or oromo)8-nitrothiochroman. Compound R may be isolated and purified by high resolution distillation or chromatography. The 7-amino-2,3-dihydrobenzo[b]thiophenes of Formula (VIII) in Equation 4b, where R'1 is CH3, H, C1, Br, OCH3, C02R5, or OSO2R7, can be prepared as shown in Equation 26 below. EMI58.1 wherein R2 and R'4 are H; R3 and R4 are as originally defined; R'1 is H, CH3, C1, Br, OCH3, C02R5 or OS02R7; R10 is H or C1-C3 alkyl; and R11 is H or CH3. The stepwise reduction of benzo[b]thiophenes to form 2,3-dihydrobenzo[b]thiophenes is known in the art, e.g., Bordwell and Stange, J. Am. Chem. Soc., 77, 5939 (1955) and Bordwell and McKellin, ibid., 73, 2251 (1951). The reactions of Equation 26 can be carried out using procedures disclosed in the cited references. In the first step, a 7-nitrobenzo[b]thiophene of Formula (XXIII), is oxidized with 30% hydrogen peroxide in acetic acid at about 500 to 1150C for 0.5 to 2 hours to form benzo[b]thiophene-l,l-dioxjde T. Intermediate T is catalytically hydrogenated with 5% palladium-on-charcoal at 1 to 3 atmospheres of pressure, at 250 to 450C, in ethanol solvent to form 2,3dihydrobenzo[b]thiophene-l,l-dioxide U. In the last step, U is refluxed with zinc and concentrated hydrochloric acid in acetic acid solvent for 1 to 3 hours to produce VIII'n. Many of the starting 7-nitrobenzo [b)thiophenes of Formula (XXIII) are described hereinafter. The 4-amino-2,3-dihydrobenzo[b]thiophenes of Formula (VIII') in Equation 4b, where R1 is H, CH3, C1, Br, OCH3, C02R5, OS02R7 or S02R6, can also be prepared using procedures described in Equations 25 and 26 above. Thus, by starting with an appropriate 5-chloro-4-nitro-2,3-dihydrobenzo[b)thiophene, and carrying out the appropriate reactions described in Equation 25 above, one skilled in the art can prepare the subject compounds, where R1 is S02R6. Similarly, by starting with an appropriate 5-(substituted)-4nitrobenzo[b]thiophene, and carrying out the appropriate reactions described in Equation 26, the subject compounds can be prepared, where R1 is H, CH3, OCH3, C1, Br, C02R5 or OSO2R7. The required starting 5-(sub stituted)-4-nitrobenzo[b]thiophenes are described hereinafter. The 4- and 7-amino-2,3-dihydrobenzo[b]thiophenes of Formula (VIII') in Equation 4b, where R, is SOvNR8Rg, can be prepared by using methods described previously in Equation 15. By starting with an appropriate 4- or 7-acetamido-2,3-dihydrobenzoEb)thiophene, and carrying out the chlorosulfonation reactions described in Equation 15, one skilled in the art can prepare the subject 4- and 7-amino-2,3-dihydrobenzo Lb)thiophenes of Formula (VIII'). The starting acetamides can be prepared by known methods, i.e., refluxing a 4- or 7-amino-2,3-dihydrobenzo[b)thiophene in acetic anhydride in the presence of sulfuric acia as catalyst. The latter amino compounds can be prepared by the Bucherer reaction, as described above in Equation 22. The 4- and 7-aminobenzotb]thiophenes of Formula (VIII') in Equation 4b, where R1, is H, R10 is H or C1-C3 alkyl and R11 is H or CH3, can also be prepared by the Bucherer reaction. By starting with an appropriate 4- or 7-hydroxybenzo(b]thiophene, and carrying out the reaction described in Equation 22, one skilled in the art can prepare the subject 4- and 7-aminobenzo [b]thiophenes of Formula (VIII'). Many of the starting 4- and 7-hydroxybenzo[b)thiophenes are known in the literature. The 4-aminobenzoEb]thiophenes of Formula (VIII) in Equation 4b, where R1, is H, OCH3, C1, Br, C02R5, or OS02R7, can be prepared as shown in Equation 27 below. Equation 27 EMI61.1 wherein R1 is H, OCH3, C1, Br, C02R5 or OS02R7; R10 is H or C1-C3 alkyl; and R11 is H or CH3. According to Equation 27, a 5-amino-4-nitrobenzo[b]thiophene of Formula (XXIV) is diazotized, then the diazonium salt is reacted with appropriate reagents to form intermediate V. Reduction of V then provides VIII'o. The diazonium salt can be prepared with sodium nitrite in dilute sulfuric acid (20 to 50%) at 0 to lO0C, a method well-known in the art for diazotizing aminobenzo[b]thiophenes, e.g, Bordwell and Stange, J. Am. Chem. Soc., 77, 5939 (1955). Intermediate V, where R1 is as defined above, can be prepared from the diazonium salt using methods described heretofore in Equation 16 by one skilled in the art. The reduction step to form VIII'o from V can be car ried out by any of several methods known in the art for reducing nitrobenzo(b)thiophenes to aminobenzo (b)thiophenes, e.g., Bordwell and Albisetti, J. Am. Chem. Soc., 70, 1955 (1948); and Martin-Smith and Reid, J. Chem. Soc., 938 (1960). Thus, refluxing V with stannous chloride and hydrochloric acid in acetic acid solvent for 0.5 to 3 hours can provide VIII'o. The starting 5-amino-4-nitrobenzo[b]thiophenes of Formula (XXIV) can be prepared by one skilled in the art according to the teachings of Bordwell and Stange, J. Am. Chem. Soc., 77, 5939 (1955); Fries et al., Ann, 527, 83 (1936); and G. Karimov et al., Dokl. Akad. Nauk. Tadzh. SSR, 13, 41 (1970), Chem. Abstr. 75:5605j. The 7-aminobenzotb)thiophenes of Formula (VIII') in Equation 4b, where R1 is H, CH3, OCH3, C1 or Br can be prepared as shown in Equation 28. Equation 28 EMI63.1 wherein R1 is H, CH3, OCH3, Cl or Br; R10 is H or C1-C3 alkyl; and R11 is CH3. The procedure of Equation 28 involves three reaction steps: (1) refluxing an appropriate 3-(substituted)-2-nitrothiophenol with an a-chloroketone such as chloropropanone in the presence of a base such as K2CO3 in acetone solvent for 1 to 10 hours to form intermediate W; cyclizing W in polyphosphoric acid at about 1000 for 1 to 24 hours to form a 6 (substituted)-7-nitrobenzobthiophene X; and reducing X to form VIII'p. The reduction can be carried out by procedures described above in Equation 27. The cyclization of thiophenoxypropanones to form benzo Eb]thiophenes is known in the art, e.g., Karimov et alc, Dokl. Akad. Nauk. Tadzh, USSR, 13, 41 (1970), Chem. Abstr. 75:5605j; and Yasuo, Nippon Kagaku Zasshi 88, 758 (1967), Chem. Abstr. 69:590189. Also, by substituting chloroacetaldehyde dimethyl acetal or 2-chloropropionaldehyde diethyl acetal for the a-chloroketone in Equation 28 above, and carrying out the procedure described therein, one skilled in the art can prepare 7-aminobenzo[b)thiophenes VIII'p, where R'1 is as defined above, R10 is H or CH3 and R11 is H. The 4- and 7-aminobenzo[b)thiophenes of Formula (VIII') in Equation 4b, where R1 is S02R6, C02Rf or 0502R7, R10 is H or C1-C3 alkyl and R11 is H or CH3, can be prepared by methods analogous to those described previously in Equation 14. Thus, by starting with an appropriate 6-chloro-7-nitrobenzo[b]thiophene or 5 chloro-4-nitrobenzotb]thiophene, and carrying out the appropriate reactions described in Equation 14, one skilled in the art can prepare the subject compounds of Formula (VIII'). The starting 5-chloro-4-nitrobenzo[b]thiophenes and 6-chloro-7-nitrobenzo[b]thio phenes are described above in Equations 27 and 28, respectively. The 4- and 7-aminobenzo[b)thiophenes of Formula (VIII') in Equation 4b, where R, is N02 or SO2NR8R9, R10 is C1-C3 alkyl and R11 is CH3, can be prepared by methods described heretofore in Equation 15. Thus, by starting with an appropriate 4- or 7-acetamidobenzo[b)- thiophene, and carrying out the nitration procedures described in Equation 15, one skilled in the art can prepare the subject 4- or 7-aminobenzo[b]thiophene of Formula (VIII'), where R1 is NO2. Similarly, by carrying out the chlorosulfonation reactions on an appropriate 4- or 7-acetamidobenzo[b]thiophene, one can prepare the subject 4- or 7-aminobenzo[b)thiophene of Formula (VIII'), where R1 is S02NR8Rg. The nitration of acetamidobenzo[b]thiophenes is known in the art, e.g., Bordwell and Stange, J. Am. Chem. Soc., 77, 5939 (1955). The chlorosulfonation of benzoEb]thio- phenes is also known, e.g., Pailer, Monatsh 92, 677 (1961). The 4- and 7-aminobenzo[b)thiophene-l,l-dioxides of Formula (VIII') in Equation 4b (Q=S02), where R1 is other then C02R5 or OS02R7, can be prepared from corresponding 4- and 7-aminobenzob]thiophenes. The preparation involves three steps: (1) acetylating the amine with acetic anhydride to form a 4- or 7-acetami dobenzo[b)thiophene; (2) oxidizing this compound with 30X hydrogen peroxide to form a 4- or 7-acetamidobenzo[b]thiophene-l,l-dioxide; and (3) deacetylating this compound to form a 4- or 7-aminobenzo[b]thiophene-l,l dioxide of Formula (VIII'). The acetylation step can be carried out in refluxing acetic anhydride with sulfuric acid catalyst by obvious methods. The oxidation step can be carried out in acetic acid solvent at 500 to 1150C for 0.5 to about 3 hours, according to the teachings of Bordwell and Stange, J. Am. Chem. Soc., 77, 5939 (1955). The deacetylation step can be car ried out by hydrolysis with hydrochloric acid or saponification with sodium hydroxide by methods described heretofore in Equation 15. Alternatively, certain 4- and 7-aminobenzotb]- thiophene-l,l-dioxides of Formula (VIII') described below can be prepared from corresponding 4- and 7-nitrobenzotb]thiophenes. This involves two steps: (1) oxidizing the nitro compound with 30% hydrogen peroxide by methods described above to form a 4- or 7-nitrobenzo[b3thiophene-1,1-dioxide; and (2) reducing this nitro compound to form a 4- or 7-aminobenzo±b)- thiophene-l,l-dioxide of Formula (VIII'). The reduction step can be carried out with warm stannous chloride and hydrochloric acid in ethanol solvent according to the teachings of Bordwell and Albisetti, J. Am. Chem. Soc., 70, 1955 (1948) and Fries et al., Ann 527 83 (1936). The starting 4- and 7-nitrobenzo[b]thiophenes have been described heretofore. By this method the 4- and 7-aminobenzo[blthiophene-l,l-dioxides of Formula (VIII') can be prepared, where R'1 is H, C1, Br, OCH3, S02R6, C02R5 or 0S02R7. The 4- and 7-amino-2,3-dihydrobenzo[b]thiophene- l,l-dioxides of Formula (VIII) in Equation 4b (Q1=s02), where R1 is other than C02R5, OS02R7 or NO2, can be prepared from corresponding 4- and 7-aminobenzo[b]thiophenes. The preparation involves four steps: (1) acetylating the amine with acetic anhydride to form a 4- or 7-acetamidobenzo[b]thiophene; (2) oxidizing this compound with 30% hydrogen peroxide to form a 4- or 7-acetamidobenzo±b]thiophene-l,l-dioxide; (3) reducing this compound catalytically with 5% palladium-on-charcoal to form a 4- or 7-acetamido-2,3-dihydro-benzo[b]thiophene-l,l-dioxide; and (4) deacetylating this compound to form a 4- or 7-amino-2,3-dihydrobenzo[b]thio- phene-l,l-dioxide of Formula (VIII'). The acetyla tion, oxidation and deacetylation steps can be carried out by methods described above for preparing 4- and 7 aminobenzo[b]thiophene-l,l-dioxides. The reduction step is best carried out at 250 to 400C at 1 to 3 atmospheres of pressure in an inert solvent such as ethanol. The catalytic reduction of benzotb]thiophene- l,l-dioxides to form 2,3-dihydrobenzo[b]thiophene-1,1dioxides is known in the art, e.g., Bordwell and Stange, J. Am. Chem. Soc., 77, 5939 (1955) and Bordwell and McKellin, ibid, 73, 2251 (1951). Also, certain 4- and 7-amino-2,3-dihydrobenzo(b)- thiophene-l,l-dioxides of Formula (VIII') described below can be prepared from corresponding 4- and 7 nitrobenzo(b)thiophenes. By starting with an appropriate 5-(substituted)-4-nitrobenzo(b]thiophene or 6-(substituted)-7-nitrobenzo[b]thiophene, and carrying out the reactions heretofore described in Equations 26a and 26b, one skilled in the art can prepare 4- and 7-amino-2,3-dihydrobenzo[b)thiophene-1,l-dioxides of Formula (VIII'), where R1 is H, C1, Br, Ch3, OCH3, S02R6, Cû2R5 or 0502R7. The starting 5-(substituted) 4-nitrobenzo[b]thiophenes and 6-(substituted)-7-nitro benzo[b)thiophenes have been described heretofore. In addition, the 4- and 7-amino-2,3-dihydrobenzo[b]thiophene-l,l-dioxides of Formula (VIII'), where R1 is other than C02R5 or 0502R7, can be prepared from corresponding 4- and 7-amino-2,3-dihydrobenzo[b]- thiophenes. The preparation involves three steps: (1) acetylating the amine with acetic anhydride to form a 4- or 7-acetamido-2,3-dihydrobenzo[b]thiophene; (2) oxidizing this compound with 30% hydrogen peroxide in acetic acid at 150 to 800C for 0.5 to about 5 hours to form a 4- or 7-acetamido-2,3-dihydrobenzo[b]thiophene-l,l-dioxide; and (3) deacetylating this compound to form the subject compounds of Formula (VIII'). The acetylation and deacetylation reactions can be run by methods described above for preparing 4- and 7-aminobenzo[b]thiophene-1,1-dioxides from corresponding amines. Similarly, the 4- and 7-amino-2,3-dihydrobenzo Eb)thiophene-1-oxides of Formula (VIII') in Equation 4b (Q1=SO), where R1 is other than CO2R5 or OSO2R7, can be prepared from corresponding 4- and 7-amino-2,3dihydrobenzo[b]thiophenes. The preparation involves three steps: (1) acetylating the amine with acetic anhydride to form a 4- or 7-acetamido-2,3-dihydrobenzo- Eb)thiophene; (2) oxidizing this compound with one mole equivalent of m-chloroperbenzoic acid to form a 4- or 7-acetamido-2,3-dihydrobenzo[b]thiophene-1oxide; and (3) deacetylating this compound to form the subject compound of Formula (VIII'). The oxidation step can be run in an inert solvent such as methylene chloride at about 0 to 100C for 1 to 16 hours, according to the teachings of Johnson and McCants, Jr., J. Am. Chem. Soc., 87, 1109 (1965). The acetylation and deacetylation steps can be run by methods aescribed above. The 4- and 7-amino-benzofurans, -benzotb]thio- phenes and -benzo±b]thiophene-1,l-dioxides of Formula (VIII') in Equation 4b, where R10 or R11 is C1 or Br, can be prepared by halogenation reactions by obvious methods. Thus, the compounds are prepared by (a) heating an appropriate 4- or 7-acetamido-benzofuran, -benzotb]thiophene or -benzo[b]thiophene-1,1- dioxide with chlorine or bromine at about 100 to 600C for 0.5 to 5 hours in an inert solvent such as chloroform or acetic acid, followed by (b) deacetylating the resulting halogenated product by one of the methods described previously in Equation 15. It will also be apparent that the amines of Formulae III and III' in Equations 1 and 3 are important intermediates for preparing the compounds of this invention. The following discussion refers to the amines III', however, it should be noted that all amines III are encompassed in the discussion of amines III'. The pyrimidines and triazines of Formula (III'a) to (III'd) below are either known or can be prepared by obvious methods by one skilled in the art. For instance, the synthesis of pyrimidines and triazines of the general formula III'a has been reviewed in "The Chemistry of Heterocyclic Compounds", a series published by Interscience Publishers, Inc., New York and London. 2-Aminopyrimidines are described by D. J. Brown in "The Pyrimidines", Vol. 16 of this series. 2-Amino-1,3,5-triazines are reviewed by E. M. Smolin and L. Rapaport in "s-Triazines and Derivatives", Vol. 13 of the same series. The synthesis of triazines is also described by F. C. Schaefer, U.S. 3,154,547 and by K. R. Huffman and F. C. Schaefer, J. Org. Chem., 28, 1812 (1963). The synthesis of the bicyclic amines III'c and III'd are described in our EP-A-0015683 and that of III'b in our ES-A-0046677. EMI69.1 EMI70.1 wherein G, X', X1, Y' and Z' are as originally defined except Y' is not CH(OCH3)2 or EMI70.2 Pyrimidines below of Formula (III'e), where Y' is CH(OC2H5)2, are described by W. Braker et al., J. Am. Chem. Soc., 69, 3072 (1947), the disclosure of which is herein incorporated by reference. Using techniques taught by Braker, or suitable modifications that would be obvious to one skilled in the art, the pyrimidines III'e can be prepared. EMI70.3 (III'e) wherein X' is CH3, OCH3 or C1; and Y' is CH(OCH3)2 or EMI70.4 Triazines of Formula (III'f) may be prepared according to the methods outlined in Equations 29 and 30. Equation 29 EMI71.1 wherein X' is CH3 or OCH3; and Yl is CH(OCH3)2 or EMI71.2 Equation 30 EMI72.1 wherein X' and Y'are as defined in Equation 29. The reaction of Equation 29a is carried out ac- cording to the teachings of J. M. McElvain and R. L. Clarke, J. Amer. Chem. Soc., 69, 2657 (1947), in which the preparation of ethyl diethoxyiminoacetate is described. The intermediate N-cyanoimidate of Formula (XXVIII) may be prepared according to the teaching of D. Lwowski in Synthesis, 1971, 263, by reacting XXVII with cyanamide at pH 5.5, and this may be condensed according to reaction 29c with either acetamidine or O-methyl isourea in an alcohdlic solvent at 25 to 80 C to provide the appropriate triazines. Alternatively, the reaction of Equation 30a, described for substituted acetonitriles by F. C. Schaefer and G. A. Peters in J. Org. Chem., 26, 412 (1961), may be used to convert nitrile of Formula XXVI to the corresponding iminoester. The free base may be carried on through reactions 30b and 30c, or, alternatively, converted to the amidinium hydrochloride salt (XXIX) as described in the aforementioned reference, and condensed with either methyl N-cyanoacetimidate or with dimethyl N-cyano imidocarbonate in the presence of one equivalent of sodium methoxide to provide the triazines of Formula (III'f). Cyclic acetals of Formula (III'h) may also be prepared from compounds of Formula (III'g) according to Equation 31 by acetal exchange. Equation 31 EMI73.1 wherein x is CH3 or OCH3; and Z' is CH or N. The reaction of Equation 31 is carried out by heating the acyclic acetal in an inert solvent in the presence of one equivalent ethylene glycol and slightly more than one equivalent of a strong acrid, such as p-toluenesulfonic acid with removal of the methanol or ethanol formed in the reaction by distillation. The product is isolated by treatment with aqueous base, and extraction with an organic solvent, and purified by crystallization or column chromatography. Preparations of 3-amino-1,2,4-triazoles of Formula (III') in Equations lb and 3b are known in trie art and 1,2,4-triazoles are reviewed in The Chemistry of Heterocyclic Compounds "Triaro:es 1,2,4" (John Wiley and Sons, New York, 1981). Commonly used starting materials containing nitrogen are N-aminoguanidine, hydrazine, alkylhydrazines, cyanamide, ethyl cyano acetimidate, dimethyl cyanodithioimidocarbonate, dimethyl cyanoimidocarbonate, ethoxymethylenecyanamide, and acylhydrazines. Some literature synthesis are illustrated below. Using these techniques or suitable modifications that would be apparent to one skilled in the art, the 3-amino-1,2,4-triazole intermediates can be readily prepared. Heating equimolar amounts of ethyl propionimidate hydrochloride and N-aminoguanidine nitrate in pyridine gives 3-amino-5-ethyltriazole; German Patent 1,073,499 (1960); Berichte, 96, 1064 (1963). EMI74.1 Condensation of hydrazine with ethyl N-cyanoacetimidate yields 3-amino-5-methyltriazole; Journal of Organic Chemistry, 28, 1816 (1963). EMI74.2 U.S. Patent 2,835,581 (1958) teaches the preparation of 3-amino-5-(hydroxymethyl)triazole from N-aminoguanidine and glycolic acid and British Patent 736,568 (1955) describes the synthesis of 3-amino-5-mercaptotriazole. EMI75.1 Condensing hydrazine with dimethyl cyanodithioim.so- carbonate in acetonitrile gives 3-amino-5-methyitio- 1,2,4-triazole while reaction of hydrazine with dimethyl N-cyanoimidocarbonate produces 3-amino-5-me- thoxy-1,2,4-triazole; Journal of Organic Chemistry 39, 1522 (1974). EMI75.2 Reaction of substituted hydrazines with N-cyanothioimidocarbonates (prepared according to the procedure given in D. M. Wieland, Ph.D. Thesis, 1971 pp. 123-124) yields disubstituted aminotriazoles as shown below. EMI76.1 Many of the aminoheterocyclic intermediates of Formula (III') where R is methyl may be prepared by a two-step procedure as described for III'i in Equation 32. Equation 32 EMI76.2 wherein X', Y' and Z' are as originally defined and R is CH3. A solution of the amine (XXX) in concentrated hydrochloric acid is treated with sodium nitrite solution and the chloro compound (XXXI) is isolated in the usual manner by filtration of the acidic solution. A representative procedure is described by Bee and Rose in J. Chem. Soc. C, 2031 (1966), for the case in which Z' = CH, and X' = Y' = OCH3. Displacement of the chlorine of (XXXI) may be accomplished by heating with an excess of methylamine in water to obtain the methylamino heterocycle (III'i). Equation 33 below illustrates the preparation of the required methyl pyrimidinyl carbamates and methyl triazinyl carbamates of Formula (V') in Equations 2b. By obvious modifications, other methyl carbamates of Formulae (V) and (V') may be prepared by this method. Equation 33 EMI77.1 wherein X', Yt, and R are as originally defined. According to Equation 33, a heterocyclic amine is reacted with two equivalents of sodium hydride and excess dimethyl carbonate to form V'a. The reaction is run in an inert solvent such as tetrahydrofuran at 250C to reflux for 1 to 24 hours. The product is isolated by (a) adding about two equivalents of concentrated hydrochloric acid under nitrogen at 0 to 300C; (b) filtering; and (c) separating out the organic phase, then drying (sodium sulfate and/or magnesium sulfate) and concentrating to dryness in vacuo. The product V'a may be purified further by recrystallization or chromatography procedures. Agriculturally suitable salts of compounds of Formulae I and I' are also useful herbicides and can be prepared by a number of ways known to the art. For example, metal salts can be made by treating compounds of Formulae I or I' with a solution of alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide, carbonate or hydride). Quaternary amine salts can be made by similar techniques. Salts of compounds of Formulae I and I' can also be prepared by exchange of one cation to another. Cationic exchange can be effected by direct treatment of an aqueous solution of a salt of a compound of Formulae I or I' (e.g., alkali metal or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water, e.g, a copper salt, and can be separated by filtration. Exchange may also be effected by passing an aqueous solution of a salt of a compound of Formulae I or I' (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged. In this method, the cation of the resin is exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water soluble, e.g., a potassium, sodium or calcium salt. Acid addition salts, useful in this invention, can be obtained by reacting a compound of Formulae I or I' with a suitable acid, e.g, p-toluenesulfonic acid, trichloroacetic acid or the like. In the following examples all parts are by weight and temperature in OC unless otherwise indicated. Example 1 2,3-Dihydro-2,2-dirnethyl-7-benzofuransulfonyl chloride A diazonium salt was prepared by adding 13.8 g of sodium nitrite to a suspension of 32.6 g of 7-amino2,3-dihydro-2,2-dimethylbenzofuran and 40 ml of concentrated sulfuric acid in 200 ml water cooled Do to 50C. After stirring for about 0.4 hour at Do to 50C, the diazonium salt suspension was poured in one portion into a mixture consisting of 170 ml of acetic acid, 40 ml of concentrated hydrochloric acid, 17 g of cupric chloride dihydrate and 30 ml of sulfur dioxide and cooled at 100C by an ice-water bath. The mixture was stirred about 1 hour at 150 to 250C. Then 400 ml of l-chlorobutane and 200 ml of water was added and the mixture was stirred and heated at 350C for 5 hours. After cooling to room temperature, the organic layer was separated, washed with saturated aqueous NaHCO3 and water, and dried over sodium sulfate for 0.5 hour. The solvent was evaporated under reduced pressure at less than 450C to give 26 g of crude 2,3dihydro-2,2-dimethyl-7-benzofuransulfonyl chloride as an oil. Example 2 2,3-Dihydro-2, 2-dimethyl-7-benzofuransulfonamide A solution of 26 g of 2,3-dihydro-2,2-dimethyl7-benzofuransulfonyl chloride prepared in Example 1, in 130 ml of tetrahydrofuran, was cooled in an icewater bath while about 30 ml of concentrated aqueous ammonium hydroxide was added portionwise at 100 to 30 C. The resulting suspension was stirred at room temperature for 3 hours, then the solvent was evaporated under reduced pressure. The residue was stirred in 150 ml of water for 0.5 hour, then filtered. The crude, wet solid was dissolved in chloroform and dried over sodium sulfate. The solvent was evaporated under reduced pressure to give a dry solid. The solid was washed once with about 100 ml of hot toluene to give 20 g of 2,3-dihydro-2,2-dimethyl-7-benzofuransulfonamide, m.p. 163-1650C. Anal. Calcd. for CloHl3NO35: C, 52.8; H, 5.8; N, 6.2; Found: C, 52.5; H, 5.7; N, 6.1. Example 3 N-(Butylaminocarbonyl)-2, 3-dihydro-2, 2-dimethyl-7- benzofuransulfonamide A solution of 19 g of 2,3-dihydro-2,2-dimethyl-7 benzofuransulfonamide prepared in Example 2 and 9.9 g of n-butyl isocyanate in 200 ml of 2-butanone was refluxed with 11.5 g of anhydrous potassium carbonate for 7 hours. The resulting mixture was concentrated to dryness in vacuo. The residue was taken up in 400 ml of water and extracted once with 100 ml of ethyl ether. The aqueous layer was acidified with 2N HC1 and the resulting mixture was filtered and suction dried. The still slightly wet solid was washed once with 100 ml of hot acetonitrile, then suction dried an additional 8 hours to give 23 g of N-(butylaminocarbonyl)-2,3-dihydro-2,2-dimethyl-7-benzofuransulfon amide, m.p. 200-2030C. Anal. Calcd. for C15H22N OS: C, 55.2; H, 6.8; N, 8.6; Found: C, 54.8; H, 6.6; N, 8.5. Example 4 2,3-Dihydro-2,2-dimethyl-7-benzofuransulfonyl isocyanate A suspension of 22 g of the N-(n-butylaminocarbonyl)-2,3-dihydro-2,2-dimethyl-7-benzofuransulfonamide prepared in Example 3, in 125 ml of xylene containing 0.3 g of DABCO was heated at 130-135 C while 5.3 ml. of phosgene was added portionwise at a rate to maintain a reflux temperature of 130-1350C. The mixture was refluxed for an additional 1.5 hours, cooled under nitrogen, and concentrated to dryness in vacuo. A sample of the crude oily product displayed a characteristic sulfonyl isocyanate band in the IR at 2200 cm -1 Example 5 N-[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]-2,3- dihydro-2,2-dimethyl-7-benzofuransulfonamide To a solution of 1.2 g of 2-amino-4,6-dimethylpyrimidine in 25 ml of tetrahydrofuran was added 2.5 g of 2,3-dihydro-2,2-dimethyl-7-benzofuransulfonyl isocyanate prepared above. After a slight exotherm the solution was stirred at room temperature for 4 hours. The solution was concentrated in vacuo to give a viscous oil that precipitated a solid from 10 ml of acetonitrile. The solid was recrystallized from acetonitrile to give 2 g of N-1(4,6-dimethylpyrimidin-2- yl)aminocarbonyl]-2,3-dihydro-2,2-dimethyl-7-benzo- furansulfonamide, m.p. 203-2060C. The IR spectrum showed a carbonyl absorption at 1680 cm 1 indicative of a sulfonylurea. Anal. Calcd. for C17H20N404S: C, 54.2; H, 5.4; N, 14.9; Found: C, 54.3; H, 5.4; N, 15.2. Example 6 Methyl (4-methyl-6-methylpyrimidin-2-yl)carbamate To a suspension of 50 g of 2-amino-4-methoxy-6methylpyrimidine in 1000 ml cf tetrahydrofuran was added portionwise, under a nitrogen atmosphere, 42.8 g of 50% sodium hydride while cooling the reaction flask in an ice-water bath. After stirring one hour at 250C, 58.5 g of dimethylcarbonate was added dropwise at 50 to 250 C. The suspension was stirred about 16 hours at ambient temperature, then 80 ml of concentrated hydrochloric acid was added dropwise while maintaining a reaction temperature of 200 to 25 C with external ice-bath cooling. The suspension was stirred 0.5 hour, filtered, and the filtrate was dried over sodium sulfate and then concentrated in vacuo. The residue was recrystallized trom hexane to yield 54 g of the title compound, m.p. 89-92.50C. Example 7 7-Amino-2,3-dihydro-2-methylbenzo[b]thiophene (2-Aminophenyl)allylsulfide (80 g) was heated at 250 -280 C for 3 hours, cooled, then subjected to spinning band distillation through a 20 cm column using a 5:1 reflux ratio. The fraction distilling at 800.820 at 0.25 mm of mercury was collected (18.0 g) and shown by NMR spectrum analysis to be the title compound in approximately 90% purity. (See also Example 21.) NMR (CDC13)6: 7.0-6.3 (m, 3H, ArH); 3.9 (m, 1H, CH); 3.5 (broad, 2H, NH2); 3.5-2.6 (m, 2H, CH2); and 1.35 (d, 3H, CH3). Example 8 7-Acetamido-2,3-dihydro-2-methylbenzo[b]thiophene To a solution of 18.0 g of 7-amino-2,3-dihydro 2-methylbenzotbzthiophene (Example 7) in 100 ml of l-cnlorobutane was added a solution of 13.0 ml of acetic anhydride in 20 ml of l-chlorobutane. After the exothermic reaction subsided, the mixture was refluxed for 0.3 hour, cooled in an ice-bath and filtered. The isolated solid was washed with 1chlorobutane to yield 15.2 9 of the title compound; m.p. 125-1270C. NMR (CDC13)6: 7.8-6.7 (m, 4H, ArH + NH); 4O (m, 1H, CH); 3.6-2.8 (m, 2H, CH2); 2.2 (s, 3H, CH3); and 1.4 (d, 3H, CH3). example 9 7-Acetamido-2,3-dihydro-2-methylbenzo[bzthiophene- 1,1-dioxide To a solution of 24.7 g of 7-acetamido-2,3-dihydro-2-methylbenzo[bjthiophene (Example 8) in 100 ml of glacial acetic acid was added dropwise 60 ml of a 30% aqueous solution of hydrogen peroxide. The reaction temperature rcse to 650C during the addition. The mixture was heatea at 65-750C for one hour, cooled to 250C, diluted with water and extracted with methylene chloride. The extract was washed with water saturated with sodium bisulfite, dried over magnesium sulfate and concentrated in vacuo. The oily reside was crystallized from l-chlorobutane to yield 14.3 3 g of the title compound as light yellow crystals; m.p. 115-1170C. NMR (CDC13)6: 8.4-7.0 (m, 4H, ArH + NH); 3.8-2.7 (m, 3H, CH2 + CH); 2 Z (s, 3H, CH3): and 1.5 (d, 3H, CH3). Example 10 2,3-Dihydro-2-methyl-7-benzo[b]thioarenesulfonamide1,l-dioxide A. ss solution of 18.6 g of 7-acetamijo-2,3dihydro-2-methylbenzo[b]thiophene-1,1-dioxide (Example 9) in iQO ml of asncentrated Hydrochloride ac i.; was refluxed for one hour to yield a suspension containing the hydrochloride salt of 7-amino-2,3-dihydro-2-methyl- benzo[b]thiophene-1,1-dioxide. B. This suspension was diluted with 25 ml of glacial acetic acia, cycled to -50C and treated with a solution of 6.4 g of sodium nitrite in 10 ml of water such that the temperature did not rise above 50C. The mixture was stirred for 0.5 hour at 8 C, then added one portion to a suspension cooled at -70C and containing 50 ml of concentrated hydrochloric acid, 50 ml of glacial acetic acid, 2.0 g cupric chloride dihydrate and 10 ml of liquified sulfur dioxide. The mixture was stirred at 200C for two hours then diluted with excess water to yield a precipitate. The mixture was filtered and the solid residue was washed with water to yield 2-methyl-2,3-dihydro-7-benzotb]thio- phenesulfonyl chloride l,l-dioxide as a crude solid. C. This solid was dissolved in -methylene chloride and contacted with 7 ml of liquified ammonia at -100C. The mixture was stirred at 200C for 16 hours, then filtered and the solids were washed with water and ether. The wet, solid residue was suspended in benzene and refluxed under a Dean-Stark trap until no more water distilled from the suspension. The suspension was cooled and filtered to yield 11.4 g of the title compound; m.p. 167-1690C. NMR (CDC13 c DMSO)6: 8.1-7.5 (m, 3H, Ar); 7.1 (broad, 2H, NH2); 3.8-2.5 (m, 3H, CH2 + CH); and 1.5 (d, 3H, CH3). IR (nujol): 3300, 3200 cm-' (NH2). Example 11 N-t(4-Methoxy-6-dethylpyrimidin-2-yl)aminocarbonyl)- 2,3-dihydro-2-methyl-7-benzo[b]thiophenesulfonamide l,l-dioxide A suspension of 1.15 g 2,3-dihydro-2-methyl-7benzo[b]thiophenesulfonamide-1,1-dioxide (Example 10) in 20 ml of dry methylene chloride was purged with nitrogen. To the slurry was added carefully 3.0 ml of a 20% toluege solution of trimethyl > aluminum (Aldrich Chemicals) while cooling the flask at 10 to 300C. After stirring for 0.2 hour, 0.9 g of methyl (4-me- thoxy-6-methylpyrimidin-2-yl)carbamate (Example 6) was added in one portion, and the suspension was refluxed under nitrogen atmosphere for 24 hours. The suspension was cooled in an ice-water bath while 20 ml of 1N hydrochloric acid was slowly added. After several minutes of stirring, the organic layer was separated, washed with water followed by water saturated with sodium chloride (brine), then dried over magnesium sulfate and concentrated in vacuo. The residue was triturated with chloroform and methylene chloride to yield 0.3 g of the title compound; m.p. 224-2260C. NMR (CDC13 + DMSO)6: 10.3 (broad, 1H, NH); 8.2-7.6 (m, 3H, Ar); 6.3 (s, 1H, CH); 4.0 (s, 3H, OCH3); 3.7-2.8 (m, 3H, CH2 + CH); 2.5 (s, 3H, CH3); and 1.5 (d, 3H, CH3). IR (nujol): 1700 cm 1 (c=o) Example 12 N-t-Butyl-2-(2-methyl-2-propenylthio)benzenesulfonamide To an ice-cooled solution of 42.6 g of N-t-butylbenzenesulfonamide in 800 ml of dry tetrahydrofuran under a nitrogen atmosphere was added dropwise 262 ml of a 1.6M solution of n-butyl lithium in hexane. The mixture was stirred for 2 hours at 200C during which time a precipitate formed. The suspension was cooled to OOC and 6.4 g of elemental sulfur was added in one portion. The mixture was warmed to 200C and stirred for one hour, then cooled at OOC while 20.5 ml of methallyl chloride was added slowly. The mixture was stirred at 200C for 16 hours, then 100 ml of 10% hydrochloric acid was added. After stirring several minutes, the organic layer was separated, washed with water and brine, dried over magnesium sulfate and concentrated in vacuo. The residue was slurried in 20% ether in hexane for several minutes and filtered to yield 47 g of the title compound; m.p. 104-1070C. NMR (CDC13)6: 8.2-7.2 (m, 4H, Ar); 5.6 (broad, 1H, NH); 4.9 (broad, 2H, vinyl); 3.7 (s, 2H, CH2); 1.9 (m, 3H, CH3); and 1.2 (s, 9H, t-butyl). Example 13 N-t-Butyl-2,3-dihydro-2,2-dimethyl-7-benzotb]thio- phenesulfonamide A solution of 37 g of N-t-butyl-2-(2-methyl-2propenylthio)benzenesulfonamide (Example 12) in 40 ml of quinoline was heated at 2200C for one hour, then cooled to 250C and diluted with ether. The ether suspension was washed well with 10% hydrochloric acid followed by water and brine, then dried over magnesium sulfate and concentrated in vacuo. The oily residue was chromatographed on 300 g of silica gel, packed and eluted with 20% ether in hexane, to give a major band which was concentrated in vacuo to yield a solid. The solid was slurried in 20% ether in hexane and filtered to yield 14.2 g of the title compound; m.p. 103-1050C. NMR (CDC13)6: 7.9-7.0 (m, 3H, Ar); 5.0 (broad, 1H, NH); 3.15 (s, 2H, CH2); 1.6 (m, 6H, CH3); and 1.2 (s, 9H, t-butyl). IR (nujol): 3200 cm 1 (NH). Example 14 2,3-Dihydro-242-dimethyl-7-benzo(b)thiophenesulfonamide A solution of 17.2 g of N-t-butyl-2,3-dihydro2,2-dimethyl-7-benzo[b]thiophenesulfonamide (Example 13) in 100 ml of trifluoroacetic acid was stirred at 200C for 16 hours. The solution was concentrated in vacuo, 100 ml of fresh trifluoroacetic acid was added and the mixture stirred at 200C for four more hours. After concentrating the solution in vacuo, the residue was dissolved in methylene chloride and the solution was washed with saturated aqueous sodium bicarbonate followed by brine, then dried over magnesium sulfate and concentrated in vacuo. The solid residue was slurried in 50% ether in hexane for several minutes then filtered to yield 8.4 g of the title compound; m.p. 102-1040C. NMR (CDC13)6: 8.9-7.0 (m, 3H, Ar); 5.1 (broad, 2H, NH2); 3.2 (s, 2H, CH2); and 1.6 (s, 6H, CH3). IR (nujol): 3300 cm 1 (NH). Example 15 2,3-Dihydro-2,2-dimethyl-7-benzo[b]thiophenesulfonyl- isocyanate To a refluxing solution of 8.6 g of 2,3-dihydro 2, 2-dimethyl-7-benzo[b)thiophenesulfonamide (Example 14), 4.0 ml of n-butylisocyanate and 0.1 g of DABCO in 100 ml of xylenes was added 3.0 ml of phosgene at such a rate that the reaction temperature did not drop below 1350C. The mixture was refluxed for 1.5 hours, then the excess phosgene was purged with a stream of dry nitrogen. The mixture was cooled, filtered and concentrated in vacuo to yield the title compound as an oil. The crude yield was assumed to be near quantitative. IR (neat) 2220 cm 1 (NCO). The oil was diluted to a volume of 88 ml with dry acetonitrile for use as a stock solution in subsequent reactions. Example 16 N-E(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2,3- dihydro-2,2-dimethyl-7-benzob]thiophenesulfonamide To 22 ml of the sulfonylisocyanate stock solution prepared in the previous Example (15) was added 0.78 g of 2-amino-4,6-dimethoxypyrimidine in one portion. The mixture was heated to reflux and stirred for 16 hours at 200C during which time a precipitate formed. The suspension was filtered and the solid washed with ether to yield 1.4 g of the title compound; m.p. 190-1920C. NMR (CDC13)6: 12.7 (broad, 1H, NH); 8.0-7.0 (m, 4H, Ar + NH); 5.8 (s, 1H, CH); 4.0 (s, 6H, OCH3); 3.15 (s, 2H, CH2); and 1.5 (s, 6H, CH3). IR (nujol): 1700 cm (c=o). Example 17 7-Nitrobenzo[b)thiophene l,l-dioxide To a solution of 24.8 g of 7-nitrobenzoEbzthio- phene in 200 ml of glacial acetic acid pre-heated to 1000C was added 90 ml of a 30% aqueous solution of hydrogen peroxide at such a rate that the temperature remained between 100 to 1050C. The solution was refluxed for one hour, then 200 ml of water was added and the mixture was cooled in an ice-bath and filtered. The solid residue was washed sequentially with water, ethanol and ether to yield 20 g of the title compound; m.p. 195-1970C. NMR (CDC13 + DMSO): 8.5 (m, 1H, Ar); 8.0 (m, 2H, Ar); 7.6 (m, 1H, Ar); and 7.2 (m, 1H, Ar). IR (nujol): 1540 and 1300 cm-1. Example 18 7-Amino-2,3-dihydrobenzo[b]thiophene 1,1-dioxide 7-Nitrobenzo[b]thiophene-1,1-dioxide (19 g, Example 17) was hydrogenated in 200 ml of ethyl acetate over 1.0 g of 10 palladium-on-charcoal.catalyst at 500 pounds-per-square-inch of pressure and 1000C until no more hydrogen gas was absorbed. The mixture was filtered through celite, and the filtrate was concentrated in vacuo. The solid residue was recrystallized from l-chlorobutane to yield 13.2 g of the title compound; m.p. 117-1190C. NMR (CDC13 + DMSO)6: 7.3-6.7 (m, 3H, Ar); 5.1 (broad, 2H, NH2); and 3.4 (m, 4H, CH2). IR (nujol): 3400, 3300, 1630 and 1590 cm 1 Example 19 2,3-Dihydro-7-benzo[b)thiophenesulfonamide l,l-dioxide A. A diazonium salt was prepared by adding a solution of 5.3 g of sodium nitrite in 10 ml of water to a suspension containing 12.8 g of 7-amino-2,3-di hydrobenzo(b)thiophene-l,l-dioxide (Example 18), 25 ml of glacial acetic acid and 75 ml of concentrated hydrochloric acid, cooled at -5 to 50C during the addition. After stirring for 0.5 hour at OOC, the diazonium salt suspension was added dropwise to a mixture consisting of 75 ml of concentrated hydrochloric acid, 50 ml of glacial acetic acid, 1.0 g of cupric chloride dihydrate and 8.0 ml of liquified sulfur dioxide, cooled at -50C during the addition. The mixture was stirred at OOC for one hour and at 200C for two hours, then diluted with excess water and stirred to yield a precipitate. The mixture was filtered and the solid residue was washed with water to yield crude 2,3-dihydro-7-benzo[b]thiophenesulfonyl chloride-l,ldioxide. B. The above sulfonyl chloride was dissolved in methylene chloride and dried over magnesium sulfate. The dried solution was contacted with 5.0 ml of liquified ammonia at -70C, then stirred at 200C for 18 hours. The suspension was concentrated in vacuo, and the residue was slurried in 100 ml of 10% hydrochloric acid, then filtered. The solid residue was washed with water and ether to yield 11.5 g of the title compound; m.p. 215-2170C. NMR (CDC13 t DMSO)6: 8.1-7.6 (m, 3H, Ar); 7.0 (broad, 2H, NH2); and 3.8-3.3 (m, 4H, CH2). IR (nujol): 3300, 3200 and 1350 cm 1. Example 20 N-C(4-Methoxy-6-methylpyrimidin-2-yl)aminocarbonyl-2,3- dihydro-7-benzo(b)thiophene l,l--dioxide A slurry of 1.0 g of 2,3-dihydro-7-benzoEb)thio- phenesulfonamide l,l-dioxide (Example 19) in 20 ml of dry methylene chloride was treated with 2.5 ml of a 20% solution of trimethylaluminum in toluene (Aldrich Chemicals) under a blanket of dry nitrogen. After stirring at 200C for 0.25 hour, 1.0 9 of methyl (4-methoxy-6-methylpyrimidin-2-yl)carbamate (Example 6) was added in one portion and the resulting solution was stirred at 200C for 60 hours followed by refluxing for 24 hours. The mixture was cooled in an ice-bath, then treated with 10 ml of 10% hydrochloric acid and filtered. The solid residue was heated in tetrahydrofuran and filtered hot to yield 0.45 g of the title compound; m.p. 227-2290C. NMR (CDC13 + DMSO)6: 13.7 (broad, lH, NH); 10.1 (broad, lH, NH); 8.2-7.7 (m, 3H, Ar); 6.3 (s, 1H, CH); 4.0 (s, 3H, OCH3); 3.5 (m, 4H, CH2); and 2.4 (s, 3H, CH3). IR (nujol): 3200 (NH), 1710 (c=o) cm 1. Example 21 8-Amino-2H-l-benzothiopyran (2-Aminophenyl)allylsulfide (55 g) was heated at 2500C for 1 hour, cooled, and then the product was distilled through a 20 cm jacketed spinning band column using a 5:1 reflux ratio. The fraction distilling at 88-9O0C at 0.25 mmHg was collected (13.3 g) and shown to be approximately 90% pure 8-aminobenzothiopyran by NMR analysis. (See also Example 7.) NMR tCDC13)6: 7.0-6.3 (m, 3H, arom); 3.7 (br, 2H, NH2); 3.0 (m, 2H, CH2); 2.7 (m, 2H, CH2); and 2.0 (m, 2H, CH2). IR (neat) 3350, 3300 and 1600 cm 1. Example 22 8-Acetamido-2H-l-benzothiopyran To a solution of 21.1 g of 8-amino-2H-l-benzothiopyran in 200 ml of l-chlorobutane was added a solution of 13.3 ml of acetic anhydride in 50 ml of l-chlorobutane. The temperature of the mixture rose during the addition and the mixture was refluxed for an additional 30 minutes. The solution was cooled in ice and filtered to give 18.0 g of the desired acetamide as colorless needles, m.p. 1330-1350C. The mother liquor was concentrated to -1/5 volume to give a second crop of 4.1 g, m.p. 1330-1350C. NMR (CDC13)6: 8.0-6.8 (m, 4H, arom + NH); 3.0 (m, 2H, CH2); 2.8 (m, 2H, CH2); and 2.1 (s and m, 5H, CH3 and CH2). IR (nujol) 3100 and 1630 cm 1. Example 23 8-Acetamino-2H-l-benzothiopyran, ,dioxide To a solution of 21.0 g of 8-acetamino-2H-l-benzothiopyran in 100 ml of glacial acetic acid was added 60 ml of 30% H202 in water. The addition was accompanied by an exotherm to 700C and the temperature was held at 700C for an additional hour. The solution was cooled, diluted with water and extracted with methylene chloride. The extract was washed with water, saturated sodium bisulfite and brine, dried over MISS04 and concentrated to give 23 g of an orange oil. The oil was dissolved in 50 ml of hot l-chlorobutane and allowed to cool to give 18.0 g of the desired dioxide as orangish-white crystals, m.p. 98-1000C. NMR (CDC13)6: 9.2 (br, 1H, NH); 8.3 (d, J=8Hz, 1H, arom); 7.4 (t, J=8Hz, 1H, arom); 7.0 (d, J=8Hz, 1H, arom); 3.4 (m, 2H, CH2); 3.0 (m, 2H, CH2); 2.5 (m, 2H, CH2); and 2.2 (s, 3H, CH3). IR (nujol) 3300 and 1690 cm 1. Example 24 8-Amino-2H-l-benzothiopyran, 1, 1-dioxide Hydrochloride A solution of 17.5 g of 8-acetamino-2H-l-benzothiopyran, l,l-dioxide in 100 ml of concentrated HC1 was heated at 80-950C for 1 hour, cooled in ice and filtered to give a white solid which was washed with ether and air dried to give 14.7 g of the free amine as its hydrochloride salt, m.p. 205-2090C. NMR (TFA): 7.9-7.5 (m, 3H, arom); 3.7 (m, 2H, CH2); 3.2 (m, 2H, CH2); and 2.7 (m, 2H, CH2). IR (nujol) 3200-2300 cm 1. Example 25 2H-l-Benzothiopyran-8-sulfonamide, l,l-dioxide To a suspension of 14.0 g of 8-amino-2H-l-benzothiopyran, l,l-dioxide hydrochloride cooled to -50C in 25 ml of concentrated HC1 and 25 ml of glacial acetic acid was added a solution of 4.55 g of sodium nitrite in 10 ml of water at such a rate that the reaction temperature did not rise above 50C. The mixture was stirred at OOC for 30 minutes then added dropwise to a solution of 50 ml of concentrated HC1, 50 ml of glacial acetic acid, 2.0 g of CuCl2e2H2O and 8 ml of liquified 502 cooled to -50C. The mixture was stirred at 0 C for 1 hour and at 200C for 2 hours during which time gas evolution was noted. The mixture was diluted with 400 ml of water and the resulting solid was filtered, washed with water and air dried. The solid was suspended in 250 ml of methylene chloride and contacted with 4 ml of liquified ammonia at -5 C. The suspension was stirred at room temperature for 65 hours, concentrated to a white powder, suspended in 100 ml of 1N HC1 and filtered to give the sulfonamide as a white solid, 14.5 g, m.p. 214-2160C (wet). 13.5 g of the wet sulfonamide was suspended in xylene and refluxed under a dean-stark trap to remove water. Cooling and filtration gave 11.5 g of the sulfonamide as a white solid, m.p. 239-2410C. NMR (CDC13 + DMSO)6: 8.2 (m, 1H, arom); 7.7-7.5 (m, 2H, arom); 7.1 (br, 2H, S02NH2); 3.7-3.1 (m, 4H, CH2's); and 2.5 (m, CH2 + DMSO solvent peak). IR (nujol) 3300, 3200, 1330 and 1170 cm 1. Example 26 2H-l-Benzothiopyran-8-sulfonylisocyanate, 1, l-dioxide A solution of 8.0 g of 2H-l-benzothiopyran-8sulfonamide, l,l-dioxide and 6.0 ml of n-butylisocya nate in 100 ml of 2-butanone was refluxed in the presence of 6.0 g of K2C03 for 16 hours. The mixture was cooled, poured into 500 g of ice-water, acidified with 10% HC1 and extracted with methylene chloride. The extract was dried over MgS04 and concentrated to give 10.2 g of the crude n-butylurea as an amber oil which solidified on standing. The crude urea was dissolved in 200 ml of dry xylenes containing 0.2 g of DABCO and 4.0 ml of n-butylisocyanate and heated to 1380C. The mixture was contacted with 4.0 ml of phosgene at such a rate that the temperature remained between 132 to l380C. The solution was refluxed for an additional hour, cooled to 250C, filtered under nitrogen and concentrated to give the crude sulfonylisocyanate as an oil. IR (neat) 2230 cm 1. The'crude sulfonylisocyanate was diluted to 120 ml with dry methylene chloride to give a stock solution for use in subsequent reactions. Example 27 N-[(4-Methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]- 2H-1-benzopyran-8-sulfonamide, l,l-dioxide 0.35 9 of 2-amino-4-methoxy-6-methylpyrimidine was added to 20 ml of the sulfonylisocyanate stock solution (ca. 1.3 g of the sulfonylisocyanate) prepared in Example 26 and the mixture stirred for 16 hours at 250C. The solution was triturated with l-chlorobutane and the crystals which formed were filtered to give 0.13 g of the desired urea, m.p. 217-2200C. NMR (CDC13 + DMSO)6: 13.4 (br, 1H, NH); 9.8 (br, 1H, NH); 8.4 (m, 1H, arom); 7.8-7.5 (m, 2H, arom); 6.3 (s, 1H, CH); 4.0 (s, 3H, OCH3); 3.5-3.0 (m, CH2's); 2.6-2.3 (m, CH2 DMSO solvent peak); and 2.4 (s, CH3). IR (nujol) 1700 cm 1 Using the techniques described in Equations 1-33 and Examples 4, 15 and 26, or simple modifications thereof, the following compounds in Table I can be made by one skilled in the art. Table I EMI100.1 R2 R3 R4 Q1 IR(cm-1) H H H O CH3 H H O CH3 CH3 H 0 2200 C2H5 H H O CH3 H CH3 O C2H5 H CH3 O H H H S CH3 H H S CH3 CH3 H S 2220 C2H5 H H S CH3 H CH3 S H H H SO2 CH3 H H SO2 CH3 CH3 H SO2 C2H5 H H SO2 CH3 H CH3 SO2 n-C3H7 H H O Using the techniques described in Equations 1-33 and Examples 5, 11, 16, 20 and 27 or simple modifications thereof, the following compounds in Tables II-IXd can be made by one skilled in the art. Table II EMI101.1 R2 R3 R4 R'4 R'1 R W Q1 X' Y' Z' m.p.( C) CH3 H H H H H O O OCH3 OCH3 CH 182-186 CH3 H H H H H O O OCH3 CH3 CH 195-198 CH3 H H H H H O O CH3 CH3 CH 178-182 CH3 H H H H H O O OCH3 OCH3 N CH3 H H H H H O O OCH3 CH3 N CH3 H H H H H O O CH3 CH3 N CH3 H H H H H O O Cl OCH3 CH CH3 CH3 H H H H O O OCH3 OCH3 CH 198-200 CH3 CH3 H H H H O O OCH3 CH3 CH 170-172 CH3 CH3 H H H H O O CH3 CH3 CH 203-206 CH3 CH3 H H H H O O OCH3 OCH3 N 164-168 CH3 CH3 H H H H O O OCH3 CH3 N 162-165 CH3 CH3 H H H H O O CH3 CH3 N 172-176 CH3 CH3 H H H H O O Cl OCH3 CH C2H5 H H H H H O O OCH3 OCH3 CH C2H5 H H H H H O O OCH3 CH3 CH C2H5 H H H H H O O CH3 CH3 CH C2H5 H H H H H O O OCH3 OCH3 N C2H5 H H H H H O O OCH3 CH3 N C2H5 H H H H H O O CH3 CH3 N H H H H H O O Cl OCH3 CH H H H H H H O O OCH3 OCH3 CH H H H H H H O O CH3 OCH3 CH Table II (continued) R2 R3 R4 R'4 R'1 R W Q1 X' Y' Z' m.p.( C) H H H H H H O O CH3 CH3 CH H H H H H H O O OCH3 OCH3 N H H H H H H O O OCH3 CH3 N H H H H H H O O CH3 CH3 N H H H H H H O O Cl OCH3 CH CH3 H CH3 H H H O O OCH3 OCH3 CH CH3 H CH3 H H H O O OCH3 CH3 CH CH3 H CH3 H H H O O CH3 CH3 CH CH3 H CH3 H H H O O OCH3 OCH3 N CH3 H CH3 H H H O O OCH3 CH3 N CH3 H CH3 H H H O O CH3 CH3 N CH3 H CH3 H H H O O Cl OCH3 CH n-C3H7 H H H H H O O OCH3 OCH3 CH n-C3H7 H H H H H O O OCH3 CH3 CH n-C3H7 H H H H H O O CH3 CH3 CH n-C3H7 H H H H H O O OCH3 OCH3 N n-C3H7 H H K H H O O OCH3 OH3 N n-C3H7 H H H H H O O Cl OCH3 CH CH3 H H H H CH3 O O OCH3 OCH3 N CH3 H H H H CH3 O O OCH3 OCH3 CH CH3 CH3 H H H CH3 O O OCH3 OCH3 N 151-152 CH3 H H H H H O S OCH3 OCH3 CH 177-179 CH3 H H H H H O S OCH3 CH3 CH 220-223 CH3 H H H H H O S CH3 CH3 CH CH3 H H H H H O S OCH3 OCH3 N 167-169 CH3 H H H H H O S OCH3 CH3 N 145-147 CH3 H H H H H O S CH3 CH3 N CH3 H H H H H O S Cl OCH3 CH CH3 CH3 H H H H O S OCH3 OCH3 CH 190-192 CH3 CH3 H H H H O S OCH3 CH3 CH 210-212 CH3 CH3 H H H H O S CH3 CH3 CH Table II (continued) R2 R3 R4 R'4 R'1 R W O1 X' Y' Z' m.p. ( C) CH3 CH3 H H H H O S OCH3 OCH3 N 146-149 CH3 CH3 H H H H O S OCH3 CH3 N 183-185 CH3 CH3 H H H H O S Cl OCH3 CH C2H5 H H H H H O S OCH3 OCH3 CH C2H5 H H H H H O S OCH3 CH3 CH C2H5 H H H H H O S CH3 CH3 CH C2H5 H H H H H O S OCH3 OCH3 N C2H5 H H H H H O S OCH3 CH3 N C2H5 H H H H H O S Cl OCH3 CH n-C3H7 H H H H H O S OCH3 OCH3 CH n-C3H7 H H H H H O S OCH3 CH3 N CH3 H CH3 H H H O S OCH3 OCH3 CH CH3 H CH3 H H H O S OCH3 CH3 CH H H H H H H O S OCH3 OCH3 CH H H H H H H O S OCH3 CH3 CH H H H H H H O S CH3 CH3 CH H H H H H H O S OCH3 OCH3 N H H H H H H O S OCH3 CH3 N H H H H H H O S Cl OCH3 CH CH3 H H H H CH3 O S OCH3 OCH3 N CH3 H H H H CH3 O S OCH3 OCH3 CH CH3 CH3 H H H CH3 O S OCH3 OCH3 N CH3 H H H H H O SO2 OCH3 OCH3 CH 234-236 CH3 H H H H H O SO2 CH3 OCH3 CH 238-240 CH3 H H H H H O SO2 CH3 CH3 CH 214-226 CH3 H H H H H O SO2 OCH3 OCH3 N 160-170 CH3 H H H H H <RTI ID=103.1> O SO2 OCH3 CH3 N 214-216 CH3 H H H H H O SO2 CH3 CH3 N CH3 H H H H H O SO2 Cl OCH3 CH 223-226 CH3 CH3 H H H H O SO2 OCH3 OCH3 CH 236-238 CH3 CH3 H H H H O SO2 OCH3 CH3 CH 228-229 Table II (continued) R2 R3 R4 R'4 R'1 R W O1 X' Y' Z' m.p.( C) CH3 CH3 H H H H O SO2 CH3 CH3 CH 228-230 CH3 CH3 H H H H O SO2 OCH3 OCH3 N 214-216 CH3 CH3 H H H H O SO2 CH3 OCH3 N 205-207 CH3 CH3 H H H H O SO2 CH3 CH3 N 208-211 CH3 CH3 H H H H O SO2 Cl OCH3 CH C2H5 H H H H H O SO2 OCH3 OCH3 CH C2H5 H H H H H O SO2 OCH3 CH3 CH C2H5 H H H H H O SO2 CH3 CH3 CH C2H5 H H H H H O SO2 OCH3 OCH3 N C2H5 H H H H H O SO2 OCH3 CH3 N C2H5 H H H H H O SO2 Cl OCH3 CH C2H5 H H H H H O SO2 OCH3 OCH3 CH n-C3H7 H H H H H O SO2 OCH3 CH3 N H H H H H H O SO2 OCH3 OCH3 CH > 300 H H H H H H O SO2 CH3 OCH3 CH 227-229 H H H H H H O SO2 CH3 CH3 CH 230-232 H H H H H H O SO2 OCH3 OCH3 N 208-210 H H H H H H O SO2 OCH3 CH3 N 210-213 H H H H H H O SO2 Cl OCH3 CH H H CH3 H H H O SO2 OCH3 OCH3 CH 232-235 H H CH3 H H H O SO2 OCH3 CH3 CH 221-223 H H CH3 H H H O SO2 CH3 CH3 CH 199-203 H H CH3 H H H O SO2 OCH3 OCH3 N 200-204 H H CH3 H H H O SO2 OCH3 CH3 N 211-213 CH3 H CH3 H H H O SO2 OCH3 OCH3 CH CH3 H CH3 H H H O SO2 OCH3 CH3 CH CH3 H CH3 H H H O SO2 CH3 CH3 CH CH3 H CH3 H H H O SO2 OCH3 CH3 N CH3 H H H H CH3 O SO2 OCH3 OCH3 CH 208-211 CH3 H H H H CH3 O SO2 OCH3 OCH3 N 160-163 CH3 CH3 H H H CH3 O SO2 OCH3 OCH3 N Table II (continued) m.p. R2 R3 R4 R'4 R'1 R W Q1 X' Y' Z' ( C) CH3 H H H H H O SO OCH3 OCH3 CH CH3 H H H H H O SO OCH3 CH3 N CH3 CH3 H Br H H O O CH3 OCH3 N CH3 H H Cl H H O O OCH3 OCH3 CH CH3 H H CH3 H H O O OCH3 OCH3 CH CH3 H H CF3 H H O O OCH3 OCH3 CH CH3 H H OCH3 H H O 0 OCH3 CH3 CH CH3 H H CH3 H H O S OCH3 OCH3 CH CH3 H H CH3 H H O SO2 OCH3 OCH3 CH CH3 H H H H H S O OCH3 OCH3 CH CH3 CH3 H H H H S O OCH3 CH3 N CH3 H H H H H S S OCH3 OCH3 CH CH3 H H H H H S S CH3 OCH3 N CH3 H H H H H S SO2 CH3 OCH3 N CH3 H H H H H S SO2 OCH3 OCH3 CH CH3 H H H CH3 H O SO2 OCH3 OCH3 CH CH3 H H H OCH3 H O O OCH3 OCH3 CH CH3 CH3 H H Cl H O S OCH3 CH3 CH CH3 H H H Br H O O OCH3 CH3 N CH3 H H H NO2 H O O OCH3 OCH3 CH CH3 H H H CO2CH3 H O O CH3 OCH3 N CH3 H H H C02C2H5 H O SO2 OCH3 OCH3 CH CH3 H H H CO2CH2CH2CH3 H O O OCH3 OCH3 CH CH3 CH3 H H CO2CH(CH3)2 H O S OCH3 OCH3 CH CH3 H H H C02CH2CH=CH2 H O O OCH3 OCH3 CH CH3 H H H CO2CH2CH2OCH3 H O O OCH3 OCH3 CH CH3 H H H CO2CH2CH2Cl H O O OCH3 OCH3 CH CH3 CH3 H H SO2CH3 H O O CH3 OCH3 CH CH3 CH3 H H SO2C2H5 H O O OCH3 CH3 CH CH3 H H H SO2CH2CH2CH3 H O O OCH3 OCH3 CH CH3 H H H SO2CH(CH3)2 H O O OCH3 OCH3 CH Table II (continued) R2 R3 R4 R'4 R'1 R Q O1 X' Y' Z' m.p.( C) CH3 H H H OSO2CH3 H O SO2 OCH3 CH3 CH CH3 H H H OSO2C2H5 H O O OCH3 OCH3 CH CH3 H H H OSO2CH2CH2CH3 H O O OCH3 OCH3 CH CH3 H H H OSO2CH(CH3)2 H O S CH3 OCH3 CH CH3 CH3 H H OSO2CF3 H O O CH3 OCH3 N CH3 H H H SO2N(CH3)2 H O O CH3 CH3 CH CH3 H H H SO2N(CH3)C2H5 H O O OCH3 OCH3 CH CH3 H H H H K O O CH3 CH3 CCI CH3 H H H H H O S H CH3 CCl CH3 H H H H H O O H CH3 CBr CH3 CH3 H H H H O S H OCH3 CCl CH3 CH3 H H H H O O H OCH3 CBr CH3 CH3 H H H H O SO2 CH3 CH3 CBr CH3 H H H H H O O H CH3 CCH3 CH3 H H H H K O O OCH3 CH3 CC2H5 CH3 CH3 H H H H O S OCH3 OC2H5 N CH3 H H H H H O O OCH3 OC2H5 CH CH3 H H H H H O SO2 OCH3 CH2OCH3 N CH3 H H H H H O O CH3 CH2OCH3 CH CH3 CH3 H H H H O O OCH3 OCH2CF3 N CH3 CH3 H H H H O S CH3 OCH2CF3 CH CH3 H H H H H O O OCH3 N(CH3)2 N CH3 H H H H H O O OCH3 N(CH3)2 CH CH3 H H H H H O O OCH3 NHCH3 N CH3 H H H H H O O CH3 C2H5 CH CH3 H H H H H O O CH3 OC2H5 N CH3 H H H H H O SO2 CH3 OC2H5 CH CH3 CH3 H H H H O O CH3 OC2CF3 N CH3 CH3 H H H H O O CH3 OCH2CH=CH2 N CH3 H H H H H O O CH3 OCH2C#CH N CH3 H H H H H O O Cl NH2 CH CH3 H H H H H O O Cl NHCH3 CH Table II (continued) EMI107.1 <tb> R2 <SEP> R3 <SEP> 4 <SEP> 4 <SEP> i <SEP> 01 <SEP> X' <SEP> Y <SEP> Z' <SEP> m.p.(OC) <tb> <SEP> 4 <SEP> 1R <SEP> W <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> C1 <SEP> N(CH3)2 <SEP> CH <tb> CH3 <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> S <SEP> OCH3 <SEP> CH(OCH3)2 <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> CH3 <SEP> CH(OCH3)2 <SEP> N <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> K <SEP> O <SEP> O <SEP> CH3 <SEP> CH(OCH3)2 <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> o <SEP> o <SEP> OCH3 <SEP> NH2 <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> 5 2 <SEP> CH3 <SEP> CF3 <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> OCH3 <SEP> NHCH3 <SEP> CH <tb> <SEP> /om <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> CH3 <SEP> CH <SEP> j <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> OCH3 <SEP> CH(OCH3)2 <SEP> CH <SEP> 111-1130 <tb> CH(CH3)2 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> o <SEP> o <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> H <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> CH3 <SEP> CH3 <SEP> N <SEP> 203-2060 <tb> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> CH3 <SEP> CH3 <SEP> N <tb> CH3 <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> o <SEP> S <SEP> CH3 <SEP> CH3 <SEP> N <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> OCH. <SEP> CH(OCH3)2 <SEP> CH <tb> <SEP> CK\00 <tb> CH3 <SEP> H <SEP> K <SEP> H <SEP> H <SEP> K <SEP> o <SEP> o <SEP> OCH3 <SEP> OK <tb> <SEP> JOm <tb> CH3 <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> o <SEP> o <SEP> OCH3 <SEP> CH <SEP> J <SEP> CH <tb> CH3 <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> CH3 <SEP> CH <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> 0 <SEP> o <SEP> OCH3 <SEP> SCH3 <SEP> N <tb> CH3 <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> OCH3 <SEP> SCH3 <SEP> N <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> OCH3 <SEP> SCH3 <SEP> OH <tb> CH3 <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> OCH3 <SEP> SCH3 <SEP> N <tb> CH3 <SEP> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> o <SEP> o <SEP> OCH3 <SEP> SCH <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> 0 <SEP> CH3 <SEP> SCH <SEP> CH <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> CH3 <SEP> 0 <SEP> SO2 <SEP> CH3 <SEP> OCH3 <SEP> CH <SEP> 220-222 <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> CH3 <SEP> 0 <SEP> S02 <SEP> CH3 <SEP> OCH3 <SEP> N <SEP> 175-180 <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> 0 <SEP> SO2 <SEP> CH3 <SEP> CH2OCH3 <SEP> CH <SEP> 203-206 <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> CH3 <SEP> C2H5 <SEP> N <SEP> 178-180 <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> CH3 <SEP> OCH2CF3 <SEP> N <SEP> 168-173 <tb> CH3 <SEP> H <SEP> H <SEP> H <SEP> H <SEP> H <SEP> 0 <SEP> SO2 <SEP> OCH3 <SEP> N(CH3)1 <SEP> N <SEP> 180-183 <tb> Table IIa EMI108.1 R2 R3 R4 R'4 R'1 R W O1 G X1 m.p.( C) CH3 CH3 H H H H O O O CH3 207-208 CH3 CH3 H H H H O O O OCH3 CH3 CH3 H H H H O O O OC2H5 CH3 H H H H H O O O CH3 CH3 H H H H H O O O OCH3 C2H5 H H H H H O O O CH3 C2H5 H H H H H O O O OCH3 n-C3H7 H H H H H O O O CH3 n-C3H7 H H H H H O O O OCH3 H H H H H H O 0 O CH3 H H H H H H O O O OCH3 CH3 H CH3 H H H O O O CH3 CH3 H CH3 H H H O O O OCH3 CH3 H H H H H O O CH2 OCH3 CH3 H H H H H O O CH2 CH3 CH3 CH3 H H H H O O CH2 OC2H5 CH3 CH3 H H H H O O CH2 OCH3 CH3 CH3 H H H H O O CH2 CH3 CH3 H H H H CH3 O O O OCH3 CH3 H H H H H O S O CH3 CH3 CH3 H H H H O S O CH3 CH3 H H H H H O S CH2 CH3 CH3 CH3 H H H H O S CH2 OCH3 Table IIa (continued) R2 R3 R4 R'4 R'1 R W Q1 G X1 m.p.( C) CH3 H H H H H O SO2 O CH3 208-210 CH3 CH3 H H H H O SO2 O CH3 CH3 H H H H H O SO2 O OCH3 CH3 CH3 H H H H O SO2 O OCH3 CH3 H H H H H O O O OCH3 CH3 CH3 H H H H O S O OCH3 CH3 H H H H H O SO2 CH2 CH3 CH3 CH3 H H H H O SO2 CH2 OCH3 C2H5 H H H H H O SO2 O CH3 CH3 CH3 H H H H S O O CH3 CH3 H H H H H S O O CH3 CH3 CH3 H H H H S SO2 O CH3 CH3 H H H H H S S O CH3 H H H H H H O SO2 O CH3 H H H H H H O SO2 O OCH3 H H H H H H O SO2 CH2 OCH3 Table IIb EMI110.1 R2 R3 R4 R'4 R'1 R W Q1 X1 m.p.( C) CH3 CH3 H H H H O O CH3 CH3 H H H H H O O CH3 CH3 CH3 H H H H O O OCH3 CH3 H H H H H O O OCH3 CH3 H H H H H O S OCH3 CH3 H H H H H O SO2 OCH3 CH3 CH3 H H H H O O OC2H5 CH3 H H H H H O O OC2H5 CH3 CH3 H H H H O S OCH3 CH3 CH3 H H H H O SO2 OCH3 CH3 H H H H H O S CH3 CH3 CH3 H H H H O S CH3 CH3 H H H H H O SO2 CH3 CH3 CH3 H H H H O SO2 CH3 H H H H H H O SO2 OCH3 H H H H H H O SO2 CH3 H H H H H H O O CH3 H H H H H H O O OCH3 CH3 H CH3 H H H O O CH3 Table IIc EMI111.1 R2 R3 R4 R' I R W Q1 X1 m.p.( C) CH3 CH3 H H H H O O CH3 CH3 H H H H H O O CH3 CH3 H CH3 H H H O O CH3 CH3 H H H H H O SO2 CH3 219-221 H H H H H H O SO2 CH3 CH3 CH3 H H Cl H O O CH3 CH3 CH3 H H H H O O OCH3 CH3 H H H H H O O OCH3 CH3 H H H H H O SO2 OCH3 CH3 CH3 H H H H O SO2 OCH3 CH3 CH3 H H H H O O OC2H5 CH3 H H H K H H 0 0 CH3 CH3 H H H H O SO2 CH3 H H H H H H O SO2 OCH3 CH3 H H H H H O S CH3 CH3 CH3 H H H H 0 5 OCH3 CH3 H CH3 H H H O O OCH3 CH3 H H H H H S O CH3 Table IId EMI112.1 R2 R3 R4 R'4 R'1 R W O1 X2 Y2 m.p.( C) CH3 CH3 H H H H O O CH3 OCH3 CH3 H H H H H O O CH3 OCH3 CH3 H CH3 H H H 0 O CH3 OCH3 H H H H H H O O CH3 OCH3 C2H5 H H H H H O O CH3 OCH3 n-C3H7 H H H H H O O CH3 OCH3 CH3 CH3 H H H H O O CH3 SCH3 CH3 H H H H H O O CH3 SCH3 CH3 H CH3 H H H O O CH3 SCH3 H H H H H H O O CH3 SCH3 C2H5 H H H H H O O CH3 SCH3 n-C3H7 H H H H H O O CH3 SCH3 CH3 H H H H H 0 O CH3 OC2H5 CH3 CH3 H H H H O O CH3 OC2H5 CH3 H H H H H O O CH3 SC2H5 CH3 CH3 H H H H O O CH3 SC2H5 CH3 H H H H H O O CH3 C2H5 CH3 CH3 H H H H O O CH3 C2H5 CH3 H H H H H O O CH3 CH3 CH3 CH3 H H H H O O CH3 CH3 CH3 H H H H H O O C2H5 OCH3 CH3 CH3 H H H H O O C2H5 SCH3 Table lId (continued) R2 R3 R4 R'4 R'1 R W O1 X2 Y2 m.p.( C) CH3 H H H H H O O CH2CF3 OCH3 CH3 H H H H H O O CH2CF3 SCH3 CH3 H H H H H S O CH3 OCH3 CH3 CH3 H H H H S O CH3 OCH3 CH3 CH3 H H H H O SO2 CH3 OCH3 CH3 H H H H H O SO2 CH3 OCH3 204-206 CH3 H CH3 H H H O SO2 CH3 OCH3 H H H H H H O SO2 CH3 OCH3 C2H5 H H H H H O SO2 CH3 OCH3 n-C3H7 H H H H H O SO2 CH3 OCH3 CH3 CH3 H H H H O SO2 CH3 SCH3 CH3 H H H H H O SO2 CH3 SCH3 CH3 H CH3 H H H O SO2 CH3 SCH3 H H H H H H O SO2 CH3 SCH3 C2H5 H H H H H O SO2 CH3 SCH3 n-C3H7 H H H H H O SO2 CH3 SCH3 CH3 CH3 H H K H C S CH3 OCH3 CH3 H H H H H O S CH3 OCH3 H H H H H H O S CH3 OCH3 C2H5 H H H H H 0 S CH3 OCH3 CH3 CH3 H H H H 0 S CH3 SCH3 CH3 H H H H H O S CH3 SCH3 H H H H H H O S CH3 SCH3 C2H5 H H H H H O S CH3 SCH3 CH3 H CH3 H H H O S CH3 OCH3 CH3 H H H H H O SO2 C2H5 OCH3 CH3 CH3 H H H H O S C2H5 SCH3 CH3 CH3 H H H H O SO2 CH2CF3 OCH3 CH3 H H H H H O S CH2CF3 SCH3 CH3 CH3 H H H H O SO2 CH3 OCH3 CH3 CH3 H H H H 0 S CH3 Table IId (continued) R2 R3 R4 R'4 R'1 R W O1 X2 Y2 m.p.( C) CH3 H H H H H O SO2 CH3 C2H5 CH3 H H H H H O S CH3 CH3 CH3 CH3 H H H H S S CH3 OCH3 CH3 CH3 H H H CH3 O O CH3 OCH3 CH3 H H H H H O SO CH3 OCH3 CH3 H H CH3 H H O O CH3 OCH3 CH3 H H H Cl H O O CH3 OCH3 Table III EMI115.1 R2 R3 R4 R1 R W Q1 X' Y' Z m.p.( C) H H H H H O O OCH3 OCH3 CH 177-180 H H H H H O O OCH3 CH3 N H H H H H O S OCH3 OCH3 CH H H H H H O S OCH3 CH3 N H H H H H O SO2 OCH3 OCH3 CH H H H H H O SO2 OCH3 CH3 N CH3 H CH3 H H O SO2 OCH3 OCH3 CH CH3 H CH3 H H O SO2 OCH3 CH3 CH H H H H H S O OCH3 OCH3 CH H H H H CH3 O O OCH3 OCH3 CH H H H H H O SO OCH3 OCH3 CH H H H H H O O Cl OCH3 CH H H H H H O SO OCH3 CH2OCH3 CH H H H H H O SO OCH3 N(CH3)2 CH Table IIIa EMI116.1 R2 R3 R4 R'1 R W Q1 G X1 m.p.( C) H H H H H O 0 0 CH3 H H H H H O 0 O OCH3 H H H H H O 0 0 OC2H5 H H H H H O O CH2 CH3 H H H H H O O CH2 OCH3 H H H H H O O CH2 OC2H H H H H H O S O CH3 H H H H H O SO2 O CH3 H H H H H O S O OCH3 H H H H H O SO2 O OCH3 H H H H H O S CH2 OCH3 H H H H H O SO2 CH2 OCH3 CH3 H CH3 H H O SO2 O OCH3 CH3 H CH3 H H O SO2 O CH3 Table IIIb EMI117.1 R2 R3 R4 R'1 R Q1 X1 W m.p.( C) H H H H H O CH3 O H H H H H SO2 CH3 O H H H H H O OCH3 O CH3 H CH3 H H S OCH3 O H H CH3 H H SO2 OCH3 O OH3 K CH3 Cl H O OCH3 O H H H H H O OC2H5 O H H H H H S CH3 O H H H H H SO CH3 O CH3 H CH3 H H O CH3 O H H H H H O CH3 S Table IIIc EMI118.1 R2 R3 R4 R'1 R Q1 X1 W m.p.( C) CH3 H CH3 H H O CH3 H H H CH3 H H SO2 CH3 H H H CH3 CH3 H SO2 CH3 H H H CH3 Cl H SO2 CH3 H H H H H H O OCH3 H H H H H H O OC2H5 H H H H H H O CH3 O H H H H H S CH3 O H H H H H SO2 CH3 O H H H H H SO CH3 O H H H H H O CH3 S CH3 H CH3 H H O OCH3 O Table III: EMI119.1 R2 R3 R4 R'I R W O1 X2 Y2 m.p.( C) H H H H H O O CH3 OCH3 H H H H H O O CH3 SCH3 H H H H H O S CH3 OCH3 H H H H H O SO2 CH3 OCH3 H H H H H O SO CH3 OCH3 H H H H H S O CH3 OCH3 CH3 K CH3 H H O O CH3 OCH3 CH3 H CH3 H H O O CH3 SCH3 H H CH3 Cl H O SO2 CH3 OCH3 Table IV EMI120.1 R'1 R10 R11 R W Q X' Y' Z' m.p.( C) H H H H O O OCH3 OCH3 CH H H H H O O OCH3 CH3 N H CH3 H H O O OCH3 OCH3 CH 188-191 H CH3 H H O O OCH3 CH3 CH 208-211 H CH3 H H O O CH3 CH3 CH 198-202 H CH3 H H O O OCH3 OCH3 N 172-176 H CH3 H H O O OCH3 CH3 N 178-181 H CH3 CH3 H O O OCH3 OCH3 CH H CH3 CH3 H O O OCH3 CH3 CH H CH3 CH3 H O O CH3 CH3 CH H CH3 CH3 H O O OCH3 OCH3 N H CH3 CH3 H O O OCH3 CH3 N H H CH3 H O O OCH3 OCH3 CH H H CH3 H O O OCH3 CH3 CH H H CH3 H O O OCH3 CH3 N H CH3 CH3 H O S OCH3 OCH3 CH H CH3 CH3 H O S OCH3 CH3 CH H CH3 CH3 H O S CH3 CH3 CH H CH3 CH3 H O S OCH3 OCH3 N H CH3 CH3 H O S OCH3 CH3 N H H CH3 H O S OCH3 OCH3 CH 216-218 H H CH3 H O S OCH3 CH3 CH 218-220 H H CH3 H O S CH3 CH3 CH H CH3 H H O O CH3 CH3 N 201-204 Table IV (continued) R1 R10 R11 R W Q X Y Z m.p.(0 C) H H CH3 H O S OCH3 OCH3 N H H CH3 H O S OCH3 CH3 N H H H H O S OCH3 OCH3 CH 204-206 H H H H O S OCH3 CH3 CH 195-197 H H H H O S CH3 CH3 CH H H H H O S OCH3 OCH3 N H H H H O S OCH3 CH3 N H H H H O S CH3 CH3 N H CH3 CH3 H O SO2 OCH3 OCH3 CH 236-239 H CH3 CH3 H O SO2 OCH3 CH3 CH 237-239 H CH3 CH3 H O SO2 CH3 CH3 CH 249-252 H CH3 CH3 H O SO2 OCH3 OCH3 N 226-230 H H CH3 H O SO2 OCH3 CH3 N H H H H O SO2 OCH3 CH3 CH H H H H O SO2 OCH3 CH3 CH H H H H O SO2 OCH3 OCH3 N H H H H O SO2 OCH3 CH3 N H H CH3 H O SO2 OCH3 OCH3 CH H H CH3 H O SO2 OCH3 CH3 CH H H CH3 H O SO2 OCH3 OCH3 N H H CH3 H O SO2 CH3 CH3 CH H CH3 H CH3 O O OCH3 OCH3 CH H CH3 H CH3 O O OCH3 OCH3 N H CH3 CH3 H O O H CH3 CCH3 H CH3 CH3 H O O OCH3 CH3 CC2H5 H H H H O S CH3 CH3 CCl H CH3 CH3 H O O H CH3 CCl H H H H O S H CH3 CBr H CH3 CH3 H O O H DCH3 CCl H H CH3 H O S CH3 CH3 CBr H CH3 H H O O CH3 NH2 CH H H CH3 H O SO2 CH3 CH3 CH Table IV (continued) R1 R10 R11 R W Q X Y Z' m.p.(0 C) H CH3 CH3 H O SO2 CH3 CH3 N 233-236 H CH3 H H O O CH3 NHCH3 CH H CH3 CH3 H O O CH3 N(CH3)2 CH H CH3 H H O O H OCH3 CBr H H H H O S OH3 OC2H5 5 CH H H CH3 H O S CH3 OC2H5 N H CH3 H H O O CH3 CH2OCH3 CH H CH3 CH3 H O O Cl OCH3 CH CH3 CH3 CH3 H O SO2 OCH3 OCH3 CH OCH3 CH3 CH3 H O S OCH3 CH3 CH Cl CH3 H H O O OCH3 CH3 N Br CH3 CH3 H O S OCH3 OCH3 CH NO2 CH3 CH3 H O O OCH3 OCH3 CH CO2CH3 CH3 CH3 H O O OCH3 CH3 CH CO2CH2(CH3)2 CH3 CH3 H O S OCH3 CH3 N CO2CH2CH2CH3 CH3 CH3 H O SO2 OCH3 CH3 N CO2CH2CH=CH2 CH3 CH3 H O O CH3 CH3 CH CO2CH2CH2OCH3 CH3 CH3 H O O CH3 CH3 CH CO2CH2CH2Cl CH3 CH3 CH3 O O CH3 CH3 CH SO2CH3 CH3 CH3 H O O OCH3 OCH3 CH SO2CH(CH3)2 CH3 CH3 H O O OCH3 CH3 N SO2CH2CH2CH3 CH3 CH3 H O O OCH3 OCH3 CH OSO2CH3 CH3 CH3 H O O OCH3 CH3 CH OSO2CH(CH3)2 CH3 CH3 H O O OCH3 CH3 N OSO2CH2CH2CH3 CH3 CH3 H O O OCH3 OCH3 CH OSO2CF3 CH3 CH3 H O SO2 OCH3 CH3 CH SO2N(CH3)2 CH3 CH3 H O S CH3 OCH3 CH SO2N(CH3)CH2CH3 CH3 CH3 H O O CH3 OCH3 N CO2C2H5 CH3 CH3 H O O CH3 OCH3 CH SO2C2H5 CH3 CH3 H O O OCH3 OCH3 CH OSO2C2H5 CH3 CH3 H O O CH3 OCH3 CH Table IV (continued) EMI123.1 <tb> Rj <SEP> R10 <SEP> Rll <SEP> R <SEP> W <SEP> Q <SEP> X' <SEP> Y' <SEP> Z' <SEP> m.p.(OC) <tb> <SEP> 11 <tb> H <SEP> H <SEP> H <SEP> H <SEP> o <SEP> o <SEP> OCH3 <SEP> CH3 <SEP> CH <tb> K <SEP> K <SEP> H <SEP> H <SEP> 00 <SEP> CH3 <SEP> CH3 <SEP> CH <tb> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> O <SEP> OCH, <SEP> OCH3 <SEP> N <tb> K <SEP> 02K5 <SEP> H <SEP> H <SEP> O <SEP> 0 <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> n-C3H7 <SEP> H <SEP> H <SEP> O <SEP> 0 <SEP> OCH <SEP> OCH3 <SEP> OK <tb> H <SEP> CH(CH3)2 <SEP> H <SEP> K <SEP> 0 <SEP> O <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> C1 <SEP> CH3 <SEP> H <SEP> o <SEP> 0 <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> Br <SEP> CH3 <SEP> H <SEP> O <SEP> O <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> CH3 <SEP> C1 <SEP> H <SEP> O <SEP> O <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> CH3 <SEP> Br <SEP> H <SEP> 0 <SEP> O <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> o <SEP> 5 <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> S <SEP> CH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> 0 <SEP> 5 <SEP> CH3 <SEP> CH3 <SEP> CH <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> S <SEP> OCH3 <SEP> CH3 <SEP> N <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> S <SEP> OCH <SEP> OCH <SEP> N <tb> H <SEP> H <SEP> H <SEP> H <SEP> 0 <SEP> S02 <SEP> CH3 <SEP> CH3 <SEP> OK <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> 502 <SEP> OCH3 <SEP> OCH3 <SEP> CH <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> 502 <SEP> OCH3 <SEP> CH3 <SEP> CH <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> CH3 <SEP> CH3 <SEP> CH <tb> K <SEP> OK3 <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> OCH3 <SEP> OCH3 <SEP> N <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> S02 <SEP> CH3 <SEP> OCH3 <SEP> N <tb> H <SEP> CH3 <SEP> CH3 <SEP> H <SEP> O <SEP> S02 <SEP> OCH3 <SEP> CH3 <SEP> N <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> O <SEP> C1 <SEP> OCH3 <SEP> CH <tb> H <SEP> H <SEP> H <SEP> H <SEP> O <SEP> 5 2 <SEP> C1 <SEP> OCH3 <SEP> CH <tb> H <SEP> CH3 <SEP> CH3- <SEP> H <SEP> 0 <SEP> 5 2 <SEP> OCH3 <SEP> CH(OCH3)2 <SEP> N <tb> H <SEP> CH3 <SEP> H <SEP> K <SEP> O <SEP> O <SEP> CH3 <SEP> 02K5 <SEP> OH <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> O <SEP> CH3 <SEP> OF <SEP> CH <tb> K <SEP> K <SEP> H <SEP> H <SEP> OS <SEP> CH3 <SEP> CH2cH=cH2 <SEP> N <tb> H <SEP> CH3 <SEP> H <SEP> H <SEP> O <SEP> 0 <SEP> 3 <SEP> OCH,CCH <SEP> N <tb> H <SEP> CH3 <SEP> K <SEP> K <SEP> 0 <SEP> 0 <SEP> OCH3 <SEP> OCH2CF3 <SEP> N <tb> H <SEP> CH <SEP> H <SEP> H <SEP> O <SEP> O <SEP> CH3 <SEP> CH <SEP> 2 <SEP> CH <tb> <SEP> 3 <SEP> sO <tb> Table IV (continued) R1 R10 R11 R W Q X' Y' Z' m.p.( C) H H H H O S Cl NH2 CH H CH3 H H O O Cl NHCH3 CH H CH3 CH3 H O SO2 Cl N(CH3)2 CH H CH3 H H S O OCH3 OCH3 CH H H H H S S OCH3 OCH3 CH H H H H S SO2 OCH3 OCH3 CH EMI124.1 <tb> 4- <SEP> # <tb> 5- <SEP> #Cl <SEP> <SEP> H <SEP> CH3 <SEP> H <SEP> O <SEP> S <SEP> CH3 <SEP> CH3 <SEP> CH <SEP> 218-220 <tb> or <SEP> 6- <SEP> # <tb> 4- <SEP> # <tb> 5- <SEP> #Cl <SEP> <SEP> H <SEP> CH3 <SEP> H <SEP> O <SEP> S <SEP> CH3 <SEP> OCH3 <SEP> CH <SEP> 231-233 <tb> or <SEP> 6- <SEP> # <tb> 4- <SEP> # <tb> 5- <SEP> #Cl <SEP> <SEP> H <SEP> CH3 <SEP> H <SEP> O <SEP> S <SEP> OCH3 <SEP> OCH3 <SEP> CH <SEP> 218-221 <tb> or <SEP> 6- <SEP> # <tb> H CH3 H H O O OCH3 SCH3 N H CH3 H H O O OCH3 SCH3 CH H H H H O S OCH3 SCH3 N H CH3 H H O O CH3 SCH3 CH Table IVa EMI125.1 R1 R10 R11 R W Q G X1 m.p. ( C) H CH3 H H O 0 O CH3 H CH3 H H O O O OCH3 H CH3 H H O O O OC2H5 H H H H O O O CH3 H CH3 CH3 H O O O CH3 H CH3 H H O O CH2 OCH3 H CH3 H H O O CH2 CH3 H CH3 H H O O CH2 OC2H5 H H H H O S O CH3 H H H H O SO2 O CH3 H CH3 CH3 H O SO2 O CH3 H CH3 CH3 H O S O CH3 H CH3 H H S O O CH3 Cl CH3 H H O O O CH3 H CH3 H CH3 O O O CH3 Table IVb EMI126.1 R1 R10 R11 R W Q X1 m.p.( C) H CH3 H H O O CH3 H CH3 H H O O OCH3 H CH3 H H O O OC2H5 H CH3 CH3 H O O CH3 H H H H O O CH3 H CH3 H H S O CH3 H CH3 H CH3 O O CH3 H CH3 CH3 H O 502 CH3 H H H H O S CH3 H H H H O S OCH3 H H H H O SO2 OCH3 Cl CH3 H H O O CH3 Table IVc EMI127.1 R1 R10 R11 R W Q X1 m.p.( C) H CH3 CH3 H O O CH3 H CH3 H H O O CH3 H H H H O O CH3 H CH3 CH3 H O SO2 CH3 H H H H O S CH3 H CH3 H H O SO2 CH3 H CH3 H H O S CH3 H CH3 CH3 H O O OCH3 H CH3 H H O O OCH3 H CH3 CH3 H O S OCH3 H CH3 CH3 H O SO2 OCH3 H H H H O S OCH3 H CH3 H H O S OCH3 H CH3 H H O O OC2H5 H CH3 H CH3 O O CH3 Cl CH3 H H O O CH3 H CH3 H H S O CH3 Table IVd EMI128.1 R1 R10 R11 R W Q X2 Y2 m.p.( C) H CH3 H H O O CH3 OCH3 H CH3 CH3 H O O CH3 OCH3 H H H H O O CH3 OCH3 H CH3 H H O O CH3 SCH3 H CH3 CH3 H O O CH3 SCH3 H H H H O O CH3 SCH3 H H H H O S CH3 OCH3 H H H H O S CH3 SCH3 H CH3 CH3 H O SO2 CH3 OCH3 H CH3 CH3 H O SO2 CH3 SCH3 H CH3 H CH3 O O CH3 OCH3 Cl CH3 H H O O CH3 OCH3 H CH3 H H 5 O CH3 OCH3 H H H H S S CH3 OCH3 H CH3 CH3 H S SO2 CH3 OCH3 H H H H O S C2H5 OCH3 H CH3 H H O O CH2CF3 OCH3 H CH3 CH3 H O SO2 CH3 OC2H5 H CH3 H H O O CH3 SC2H5 H CH3 H H O O CH3 C2H5 H CH3 H H O O CH3 CH3 Table V EMI129.1 R1 R10 R11 R W Q X' Y' Z' m.p.( C) H H H H O O OCH3 OCH3 CH H H H H O O OCH3 CH3 N H H CH3 H O O OCH3 OCH3 CH H H CH3 H O O OCH3 CH3 N H H H H S O OCH3 OCH3 CH H H CH3 H O S OCH3 OCH3 CH H H CH3 H O SO2 OCH3 OCH3 CH H H CH3 H O SO2 OCH3 CH3 N H CH3 CH3 H O O OCH3 OCH3 CH Table Va EMI130.1 R1 R10 R11 R W Q G X1 m.p.( C) H H CH3 H O O O CH3 H CH3 CH3 H O 0 O OCH3 H H CH3 H O 0 O OC2H5 H H H H O S O CH3 H H CH3 H O SO2 O CH3 H H CH3 H 0 O CH2 CH3 H H H H O S CH2 OCH3 H H H H O SO2 CH2 OC2H5 H H CH3 H S 0 O CH3 Cl H CH3 H O O O CH3 Table Vb EMI131.1 R1 R10 R11 R W Q X1 m.p.( C) H H CH3 H O O CH3 H H CH3 H O S CH3 Cl H CH3 H O O CH3 H H CH3 H O SO2 CH3 H CH3 CH3 H O O OCH3 H H CH3 H O S OCH3 H H CH3 CH3 O S OCH3 H H CH3 H O S OCH3 H H H H O O OCH3 H H CH3 H O O OC2H5 H H H H S O CH3 Table Vc EMI132.1 R1 R10 R11 R W Q X1 m.p.( C) H CH3 CH3 H O O CH3 H H CH3 H O S CH3 H H CH3 H O SO2 CH3 H H CH3 H O O OCH3 H H CH3 H O S OCH3 H CH3 CH3 H O SO2 OCH3 H H CH3 H O SO2 OCH3 H H H H O O OC2H5 H H H H S O CH3 H H CH3 H S SO2 CH3 Cl H CH3 H S O CH3 Table Vd EMI133.1 R1' R10 R11 R W Q X2 Y2 m.p.( C) H H CH3 H O O CH3 OCH3 H H CH3 H O O CH3 SCH3 H CH3 CH3 H O O CH3 OCH3 H H CH3 H S O CH3 OCH3 H CH3 CH3 H O S CH3 OCH3 H H H H O SO2 CH3 OCH3 Cl H CH3 H O O CH3 OCH3 Table VIa EMI134.1 n Q R R1 R2 R3 R4 X Y Z m.p. ( ) O O H H H H H CH3 CH3 CH O O H H H H H CH3 OCH3 CH O O H H H H H OCH3 OCH3 CH O O H H H H H CH3 CH3 N O O H H H H H CH3 OCH3 N O O H H H H H OCH3 OCH3 N O S H H H H H CH3 CH3 CH O S H H H H H CH3 OCH3 CH O S H H H H H OCH3 OCH3 CH O S H H H H H CH3 CH3 N O S H H H H H CH3 OCH3 N O S H H H H H OCH3 OCH3 N O SO2 H H H H H CH3 CH3 CH 214-216 O SO2 H H H H H CH3 OCH3 CH 217-220 O SO2 H H H H H OCH3 OCH3 CH 208-216 O SO2 H H H H H CH3 CH3 N O SO2 H H H H H CH3 OCH3 N 214-218 O SO2 H H H H H OCH3 OCH3 N O O H H CH3 H H CH3 CH3 CH O O H H CH3 H H CH3 OCH3 CH O O H H CH3 H H OCH3 OCH3 CH O O H H CH3 H H CH3 CH3 N O O H H CH3 H H CH3 OCH3 N Table VIa (continued) n Q R R1 R2 R3 R4 X Y T m.p.( ) O O H H CH3 H H OCH3 OCH3 N O S H H CH3 H H CH3 CH3 CH O S H H CH3 H H CH3 OCH3 CH O S H H CH3 H H OCH3 OCH3 CH O S H H CH3 H H CH3 CH3 N O S H H CH3 H H CH3 OCH3 N O S H H CH3 H H OCH3 OCH3 N O SO2 H H CH3 H H CH3 CH3 CH O SO2 H H CH3 H H CH3 OCH3 CH O SO2 H H CH3 H H OCH3 OCH3 CH O SO2 H H CH3 H H CH3 CH3 N O SO2 H H CH3 H H CH3 OCH3 N O SO2 H H CH3 H H OCH3 OCH3 N O O H H CH3 CH3 H CH3 CH3 CH O O H H CH3 CH3 H CH3 OCH3 CH O O H H CH3 CH3 H OCH3 OCH3 CH O O H H CH3 CH3 H CH3 CH3 N O O H H CH3 CH3 H CH3 OCH3 N O O H H CH3 CH3 H OCH3 OCH3 N O S H H CH3 CH3 H CH3 CH3 CH O S H H CH3 CH3 H CH3 OCH3 CH O S H H CH3 CH3 H OCH3 OCH3 CH O S H H CH3 CH3 H CH3 CH3 N O S H H CH3 CH3 H CH3 OCH3 N O S H H CH3 CH3 H OCH3 OCH3 N O SO2 H H CH3 CH3 H CH3 CH3 CH O SO2 H H CH3 CH3 H CH3 OCH3 CH O SO2 H H CH3 CH3 H OCH3 OCH3 CH O SO2 H H CH3 CH3 H CH3 CH3 N O SO2 H H CH3 CH3 H CH3 OCH3 N O SO2 H H CH3 CH3 H OCH3 OCH3 N 1 O H H H H H CH3 CH3 CH Table VIa (continued) n Q R R1 R2 R3 R4 X Y T m.p.( ) 1 O H H H H H CH3 OCH3 CH 1 O H H H H H OCH3 OCH3 CH 1 O H H H H H CH3 CH3 N 1 O H H H H H CH3 OCH3 N 1 O H H H H H OCH3 OCH3 N 1 S H H H H H CH3 CH3 CH 1 S H H H H H CH3 OCH3 CH 1 S H H H H H OCH3 OCH3 CH 1 S H H H H H CH3 CH3 N 1 S H H H H H CH3 OCH3 N 1 S H H H H H OCH3 OCH3 N 1 SO2 H H H H H CH3 CH3 CH 1 SO2 H H H H H CH3 OCH3 CH 1 SO2 H H H H H OCH3 OCH3 CH 1 SO2 H H H H H CH3 CH3 N 1 SO2 H H H H H CH3 OCH3 N 1 SO2 H H H H H OCH3 OCH3 N 1 O H H CH3 H H CH3 CH3 CH 1 O H H CH3 H H CH3 OCH3 CH 1 O H H CH3 H H CH3 OCH3 CH 1 O H H CH3 H H CH3 CH3 N 1 O H H CH3 H H CH3 OCH3 N 1 O H H CH3 H H OCH3 OCH3 N 1 S H H CH3 H H CH3 CH3 CH 1 S H H CH3 H H CH3 OCH3 CH 1 S H H CH3 H H OCH3 OCH3 CH 1 S H H CH3 H H CH3 CH3 N 1 S H H CH3 H H CH3 OCH3 N 1 S H H CH3 H H OCH3 OCH3 N 1 SO2 H H CH3 H H CH3 CH3 CH 1 SO2 H H CH3 H H CH3 OCH3 CH 1 SO2 H H CH3 H H CH3 OCH3 CH Table VIa (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) 1 SO2 H H CH3 H H CH3 CH3 N 1 SO2 H H CH3 H H CH3 OCH3 N 1 SO2 H H CH3 H H OCH3 OCH3 N 1 O H H CH3 CH3 H CH3 CH3 CH 1 O H H CH3 CH3 H CH3 OCH3 CH 1 O H H CH3 CH3 H CH3 OCH3 CH 1 O H H CH3 CH3 H CH3 CH3 N 1 O H H CH3 CH3 H CH3 OCH3 N 1 O H H CH3 CH3 H OCH3 OCH3 N 1 S H H CH3 CH3 H CH3 CH3 CH 1 S H H CH3 CH3 H CH3 OCH3 CH 1 S H H CH3 CH3 H OCH3 OCH3 CH 1 S H H CH3 CH3 H CH3 CH3 N 1 S H H CH3 CH3 H CH3 OCH3 N 1 S H H CH3 CH3 H CH3 OCH3 N 1 SO2 H H CH3 CH3 H CH3 CH3 CH 1 SO2 H H CH3 CH3 H CH3 OCH3 CH 1 SO2 H H CH3 CH3 H OCH3 OCH3 CH 1 SO2 H H CH3 CH3 H CH3 CH3 N 1 SO2 H H CH3 OH3 K CH3 OCH3 N 1 SO2 H H CH3 CH3 H OCH3 OCH3 N O SO2 CH3 H CH3 CH3 H OCH3 OCH3 N O SO2 H H CH3 CH3 CH3 CH3 CH3 CH O SO2 H H CH3 CH3 CH3 CH3 OCH3 CH 243-245 O SO2 H H CH3 CH3 CH3 OCH3 OCH3 CH 244-245 O SO2 H H CH3 CH3 CH3 CH3 CH3 N O SO2 H H CH3 CH3 CH3 CH3 OCH3 N 206-209 O SO2 H H CH3 CH3 CH3 OCH3 OCH3 N 228-230 O O H OCH3 CH3 CH3 H CH3 CH3 CH O O H OCH3 CH3 CH3 H CH3 OCH3 CH O O H OCH3 CH3 CH3 H CH3 OCH3 CH O O H OCH3 CH3 CH3 H CH3 CH3 N Table VIa (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) O O H OCH3 CH3 CH3 H CH3 OCH3 N O O H OCH3 CH3 CH3 H OCH3 OCH3 N O O H OCH3 CH3 CH3 H OCH3 OCH3 CH O S H Cl CH3 K H OCH3 OCH3 CH O SO2 H Br H CH3 H OCH3 OCH3 CH O O H CO2CH3 CH3 CH3 H CH3 OCH3 CH O S H CO2CH2CH3 H CH3 H OCH3 OCH3 CH O SO2 H CO2CH2CH2CH3 CH3 H H CH3 OCH3 N O O H CO2CH(CH3)2 H CH3 H OCH3 OCH3 N O S H CO2CH2CH=CH2 CH3 H H CH3 OCH3 CH O SO2 H CO2CH2CHOCH3 H CH3 H OCH3 OCH3 CH 0 O H C02CH2CH2C1 CH3 H H CH3 OCH3 N O S H SO2CH3 H CH3 H OCH3 OCH3 N O SO2 H SO2CH2CH2CH3 CH3 H H CH3 OCH3 CH O O H SO2CH(CH3)2 H CH3 H OCH3 OCH3 CH O S H OSO2CH3 CH3 H H CH3 OCH3 N O SO2 H OSO2CF3 H CH3 H OCH3 OCH3 N O O H OSO2CH(CH3)2 H CH3 H CH3 OCH3 CH O SO2 H SO2N(CH3)2 CH3 H H OCH3 OCH3 CH O SO2 H SO2N(CH2CH3)2 H CH3 H CH3 OCH3 N O O H SO2N(CH3)CH2CH3 H CH3 H OCH3 OCH3 N O S H H CH3 CH2CH3 H CH3 OCH3 CH O SO2 H H H CH2CH2CH3 H OCH3 OCH3 CH O O H H H CH(CH3)2 H CH3 OCH3 N O S H H CH2CH3 H H OCH3 OCH3 N O SO2 H H CH2CH2CH3 H H CH3 OCH3 CH O O H H CH(CH3)2 H H OCH3 OCH3 CH O S H H H CH3 H Cl OCH3 CH O SO2 H H CH3 H H CH3 NH2 CH O O H H H CH3 H CH3 NHCH3 CH O S H H CH3 H H CH3 N(CH3)2 CH O SO2 H H H CH3 H CH3 OC2H5 CH Table VIa (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) O O H H CH3 H H CH3 OCH2CH3 N O S H H H CH3 H OCH3 CH2OCH3 CH Table VIb EMI140.1 n Q R R1 R2 R3 R4 X1 G m.p.( ) 0 SO2 H H H H H CH3 CH2 0 SO2 H H H H H OCH3 CH2 0 SO2 H H H H H OCH2CH3 CH2 0 SO2 H H H H H CH3 O 0 SO2 H H H H H OCH3 O 0 SO2 H H H H H OCH2CH3 O 0 SO2 H H H H CH3 OCH3 O 0 O H H H CH3 H OCH3 O 0 S H H CH3 H H OCH3 O 0 SO2 H H H CH3 H OCH3 O 0 S H CH3 CH3 H H OCH3 O 0 SO2 H OCH3 CH3 H H OCH3 O 0 S H Cl CH3 H H OCH3 O 0 SO2 H Br CH3 H H OCH3 O 0 S H CO2CH3 CH3 H H OCH3 O 0 SO2 H SO2CH3 CH3 H H OCH3 O 0 S H OSO2CH3 CH3 H H OCH3 O 0 SO2 H SO2N(CH3)2 CH3 H H OCH3 O 1 SO2 H H H H H OCH3 O Table VIc EMI141.1 n Q R R1 R2 R3 R4 X1 m.p.( ) 0 SO2 H H H H H CH3 0 SO2 H H H H H OCH3 0 SO2 H H H H H OCH2CH3 0 SO2 H H H H CH3 OCH3 0 O H H H CH3 H OCH3 0 S H H CH3 H H OCH3 0 SO2 H H H CH3 H OCH3 0 S H CH3 CH3 H H OCH3 0 SO2 H OCH3 CH3 H H OCH3 0 S H Cl CH3 H H OCH3 0 SO2 H Br CH3 H H OCH3 0 S H CO2CH3 CH3 H H OCH3 0 SO2 H SO2CH3 CH3 H H OCH3 0 S H OSO2CH3 CH3 H H OCH3 0 SO2 H SO2N(CH3)2 CH3 H H OCH3 1 SO2 H H H H H OCH3 Table VId EMI142.1 n Q R R1 R2 R3 R4 X1 m.p.( ) 0 SO2 H H H H H CH3 0 SO2 H H H H H OCH3 0 SO2 H H H H H OCH2CH3 0 SO2 H H H H CH3 OCH3 0 O H H H CH3 H OCH3 0 S H H CH3 H H OCH3 0 SO2 H H H CH3 H OCH3 0 S H CH3 CH3 H H OCH3 0 SO2 H OCH3 CH3 H H OCH3 0 S H Cl CH3 H H OCH3 0 SO2 H Br CH3 H H OCH3 0 S H CO2CH3 CH3 H H OCH3 0 SO2 H SO2CH3 CH3 H H OCH3 0 S H OSO2CH3 CH3 H H OCH3 0 SO2 H SO2N(CH3)2 CH3 H H OCH3 1 SO2 H H H H H OCH3 Table VIIa EMI143.1 n Q R R1 R2 R3 R4 X Y Z m.p.( ) 0 O H H H H H CH3 CH3 CH 0 O H H H H H CH3 OCH3 CH 0 O H H H H H OCH3 OCH3 CH 0 O H H H H H CH3 CH3 N 0 O H H H H H CH3 OCH3 N 0 O H H H H H OCH3 OCH3 N 0 S H H H H H CH3 CH3 CH 0 S H H H H H CH3 OCH3 CH 0 S H H H H H OCH3 OCH3 CH O S K H H H H CH3 CH3 N 0 S H H H H H CH3 OCH3 N 0 S H H H H H OCH3 OCH3 N 0 SO2 H H H H H CH3 CH3 CH 0 SO2 H H H H H CH3 OCH3 CH 0 SO2 H H H H H OCH3 OCH3 CH 0 SO2 H H H H H CH3 CH3 N 0 SO2 H H H H H CH3 OCH3 N 0 SO2 H H H H H OCH3 OCH3 N 0 O H H CH3 H H CH3 CH3 CH 0 O H H CH3 H H CH3 OCH3 CH 0 O H H CH3 H H CH3 OCH3 CH 0 O H H CH3 H H CH3 CH3 N 0 O H H CH3 H H CH3 OCH3 N Table VIla (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) 0 O H H CH3 H H CH3 OCH3 N 0 S H H CH3 H H CH3 CH3 CH 0 S H H CH3 H H CH3 OCH3 CH 0 S H H CH3 H H OCH3 OCH3 CH O S H H CH3 H H CH3 CH3 N 0 S H H CH3 H H CH3 OCH3 N 0 S H H CH3 H H CH3 OCH3 N 0 SO2 H H CH3 H H CH3 CH3 CH 0 SO2 H H CH3 H H CH3 OCH3 CH 0 SO2 H H CH3 H H OCH3 OCH3 CH 0 SO2 H H CH3 H H CH3 CH3 N 0 SO2 H H CH3 H H CH3 OCH3 N 0 SO2 H H CH3 H H OCH3 OCH3 N 0 O H H CH3 CH3 H CH3 CH3 CH 0 O H H CH3 CH3 H CH3 OCH3 CH 0 O H H CH3 CH3 H OCH3 OCH3 CH 0 O H H CH3 CH3 H CH3 CH3 N 0 O H H CH3 CH3 H CH3 OCH3 N 0 O H H CH3 CH3 H OCH3 OCH3 N 0 S H H CH3 CH3 H CH3 CH3 CH 0 S H H CH3 CH3 H CH3 OCH3 CH 0 S H H CH3 CH3 H OCH3 OCH3 CH 0 S H H CH3 CH3 H CH3 CH3 N 0 S H H CH3 CH3 H CH3 OCH3 N 0 S H H CH3 CH3 H OCH3 OCH3 N 0 SO2 H H CH3 CH3 H CH3 CH3 CH 0 SO2 H H CH3 CH3 H CH3 OCH3 CH 0 SO2 H H CH3 CH3 H OCH3 OCH3 CH 0 SO2 H H CH3 CH3 H CH3 CH3 N 0 SO2 H H CH3 CH3 H CH3 OCH3 N 0 SO2 H H CH3 CH3 H OCH3 OCH3 N 0 SO2 H H H H H CH3 CH3 CH Table VIIa (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) 1 O H H H H H CH3 OCH3 CH 1 O H H H H H OCH3 OCH3 CH 1 O H H H H H CH3 CH3 N 1 O H H H H H CH3 OCH3 N 1 O H H H H H OCH3 OCH3 N 1 S H H H H H CH3 CH3 CH 1 S H H H H H CH3 OCH3 CH 1 S H H H H H OCH3 OCH3 CH 1 S H H H H H CH3 CH3 N 1 S H H H H H CH3 OCH3 N 1 S H H H H H OCH3 OCH3 N 1 SO2 H H H H H CH3 OCH3 CH 1 SO2 H H H H H CH3 OCH3 CH 1 SO2 H H H H H OCH3 OCH3 CH 1 SO2 H H H H H CH3 CH3 N 1 SO2 H H H H H CH3 OCH3 N 1 SO2 H H H H H OCH3 OCH3 N 1 O H H CH3 H H CH3 CH3 CH 1 O H H CH3 H H CH3 OCH3 CH 1 O H H CH3 H H OCH3 OCH3 CH 1 O H H CH3 H H CH3 CH3 N 1 O H H CH3 H H CH3 OCH3 N 1 O H H CH3 H H OCH3 OCH3 N 1 S H H CH3 H H CH3 CH3 CH 1 S H H CH3 H H CH3 OCH3 CH 1 S H H CH3 H H OCH3 OCH3 CH 1 S H H CH3 H H CH3 CH3 N 1 S H H CH3 H H CH3 OCH3 N 1 S H H CH3 H H OCH3 OCH3 N 1 SO2 H H CH3 H H CH3 CH3 CH 1 SO2 H H CH3 H H CH3 OCH3 CH 1 SO2 H H CH3 H H CH3 OCH3 CH Table VIIa (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) 1 SO2 H H CH3 H H CH3 CH3 N 1 SO2 H H CH3 H H CH3 OCH3 N 1 SO2 H H CH3 H H OCH3 OCH3 N 1 O H H CH3 CH3 H CH3 CH3 CH 1 O H H CH3 CH3 H CH3 OCH3 CH 1 O H H CH3 CH3 H OCH3 OCH3 CH 1 O H H CH3 CH3 H CH3 CH3 N 1 O H H CH3 CH3 H CH3 OCH3 N 1 O H H CH3 CH3 H OCH3 OCH3 N 1 S H H CH3 CH3 H CH3 CH3 CH 1 S H H CH3 CH3 H CH3 OCH3 CH 1 S H H CH3 CH3 H OCH3 OCH3 CH 1 S H H CH3 CH3 H CH3 CH3 N 1 S H H CH3 CH3 H CH3 OCH3 N 1 S H H CH3 CH3 H OCH3 OCH3 N 1 SO2 H H CH3 CH3 H CH3 CH3 CH 1 SO2 H H CH3 CH3 H CH3 OCH3 CH 1 SO2 H H CH3 CH3 H OCH3 OCH3 CH 1 SO2 H H CH3 CH3 H CH3 CH3 N 1 SO2 H H CH3 CH3 H CH3 OCH3 N 1 SO2 H H CH3 CH3 H CH3 OCH3 N 0 SO2 CH3 H CH3 H H OCH3 OCH3 N 0 SO2 H H H H CH3 CH3 CH3 CH 0 SO2 H H H H CH3 CH3 OCH3 CH 0 SO2 H H H H CH3 OCH3 OCH3 CH 0 SO2 H H H H CH3 CH3 OCH3 N 0 SO2 H H H H CH3 CH3 OCH3 N 0 SO2 H H H H CH3 OCH3 OCH3 N 0 O H OCH3 CH3 CH3 H CH3 CH3 CH 0 O H OCH3 CH3 CH3 H CH3 OCH3 CH 0 O H OCH3 CH3 CH3 H OCH3 OCH3 CH 0 O H OCH3 CH3 CH3 H CH3 CH3 N Table VIIa (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) 0 O H OCH3 CH3 CH3 H CH3 OCH3 N 0 O H OCH3 CH3 CH3 H OCH3 OCH3 N 0 O H CH3 H H H OCH3 OCH3 CH 0 O H Cl CH3 H H OCH3 OCH3 CH 0 SO2 H Br H CH3 H OCH3 OCH3 CH 0 O H CO2CH3 CH3 H H CH3 OCH3 CH 0 S H CO2CH2CH3 H CH3 H OCH3 OCH3 CH 0 SO2 H CO2CH2CH2CH3 CH3 H H CH3 OCH3 N 0 S H CO2CH(CH3)2 H CH3 H OCH3 OCH3 N 0 S H CO2CH2CH=CH2 CH3 H H CH3 OCH3 CH 0 SO2 H CO2CH2CH2OCH3 H CH3 H OCH3 OCH3 CH 0 O H CO2CH2CH2Cl CH3 H H CH3 OCH3 N 0 S H SO2CH3 H CH3 H OCH3 OCH3 N 0 SO2 H SO2CH2CH2CH3 CH3 H H CH3 OCH3 CH 0 O H SO2CH(CH3)2 H CH3 H OCH3 OCH3 CH 0 O H OSO2CH3 CH3 H H CH3 OCH3 N 0 SO2 H OSO2CF3 H CH3 H OCH3 OCH3 N 0 O H OSO2CH(CH3)2 H CH3 H CH3 OCH3 CH 0 SO2 H SO2N(CH3)2 CH3 H H OCH3 OCH3 CH 0 SO2 H SO2N(CH2CH3)2 H CH3 H CH3 OCH3 N 0 O H SO2N(CH3)CH2CH3 CH3 H H OCH3 OCH3 N 0 S H H CH3 CH2CH3 H CH3 OCH3 CH 0 SO2 H H H CH2CH2CH3 H OCH3 OCH3 CH 0 O H H H CH(CH3)2 H CH3 OCH3 N 0 S H H CH2CH3 H H OCH3 OCH3 N 0 SO2 H H CH2CH2CH3 H H CH3 OCH3 CH 0 O H H CH(CH3)2 H H OCH3 OCH3 CH 0 S H H H CH3 H Cl OCH3 CH 0 SO2 H H CH3 H H CH3 NH2 CH 0 O H H H CH3 H CH3 NHCH3 CH 0 S H H CH3 H H CH3 N(CH3)2 CH 0 SO2 H H H CH3 H CH3 OC2H5 CH Table VIIa (continued) n Q R R1 R2 R3 R4 X Y Z m.p.( ) 0 O H H CH3 H H CH3 OCH2CH3 N 0 S H H H CH3 H OCH3 CH2OCH3 CH TaDle VIIb EMI149.1 n Q R R1 R2 R3 R4 X1 G m.p.( ) 0 SO2 H H H H H CH3 CH2 0 SO2 H H H H H OCH3 CH2 0 SO2 H H H H H OCH2CH3 CH2 0 SO2 H H H H H CH3 O 0 SO2 H H H H H OCH3 O 0 SO2 H H H H H OCH2CH3 O 0 SO2 H H H H CH3 OCH3 O 0 O H H H CH3 H OCH3 O 0 S H H CH3 H H OCH3 O 0 SO2 H H H CH3 H OCH3 O 0 S H CH3 CH3 H H OCH3 O 0 SO2 H OCH3 CH3 H H OCH3 O 0 S H Cl CH3 H H OCH3 O 0 SO2 H Br CH3 H H OCH3 O 0 S H CO2CH3 CH3 H H OCH3 O 0 SO2 H SO2CH3 CH3 H H OCH3 O 0 S H OSO2CH3 CH3 H H OCH3 O 0 SO2 H SO2N(CH3)2 CH3 H H OCH3 O 1 SO2 H H CH3 H H OCH3 O Table VIIe EMI150.1 n Q R R1 R2 R3 R4 X1 m.p.( ) 0 SO2 H H H H H CH3 0 SO2 H H H H H OCH3 0 SO2 H H H H H OCH2CH3 0 SO2 H H H H CH3 OCH3 0 O H H H CH3 H OCH3 0 S H H CH3 H H OCH3 0 SO2 H H H CH3 H OCH3 0 S H CH3 CH3 H H OCH3 0 SO2 H OCH3 CH3 H H OCH3 0 S H Cl CH3 H H OCH3 0 SO2 H Br CH3 H H OCH3 0 S H CO2CH3 CH3 H H OCH3 0 SO2 H SO2CH3 CH3 H H OCH3 0 S H OSO2CH3 CH3 H H OCH3 0 SO2 H SO2N(CH3)2 CH3 H H OCH3 1 SO2 H H H H H OCH3 Table VIId EMI151.1 N Q R R1 R2 R3 R4 X1 m.p.( ) 0 SO2 H H H H H CH3 0 SO2 H H H H H OCH3 0 SO2 H H H H H OCH2CH3 0 SO2 H H H H CH3 OCH3 0 O H H H CH3 H OCH3 0 S H H CH3 H H OCH3 0 SO2 H H H CH3 H OCH3 0 S H CH3 CH3 H H OCH3 0 SO2 H OCH3 CH3 H H OCH3 0 S H Cl CH3 H H OCH3 0 SO2 H Br CH3 H H OCH3 0 S H CO2CH3 CH3 H H OCH3 0 SO2 H SO2CH3 CH3 H H OCH3 0 S H OSO2CH3 CH3 H H OCH3 0 SO2 H SO2N(CH3)2 CH3 H H OCH3 1 SO2 H H H H H OCH3 Table VIIIa EMI152.1 n Q R R1 R2 R4 X Y Z m.p.( ) 0 S H H H H CH3 CH3 CH 0 S H H H H CH3 OCH3 CH 0 S H H H H OCH3 OCH3 CH 0 S H H H H CH3 CH3 N 0 S H H H H CH3 OCH3 N 0 S H H H H OCH3 OCH3 N 0 SO2 H H H H CH3 CH3 CH 0 SO2 H H H H CH3 OCH3 CH 0 SO2 H H H H OCH3 OCH3 CH 0 SO2 H H H H CH3 CH3 N 0 SO2 H H H H CH3 OCH3 N 0 SO2 H H H H OCH3 OCH3 N 0 S H H CH3 H CH3 CH3 CH 0 S H H CH3 H OCH3 OCH3 CH 0 S H H CH3 H OCH3 OCH3 CH 0 S H H CH3 H CH3 CH3 N 0 S H H CH3 H CH3 OCH3 N 0 S H H CH3 H OCH3 OCH3 N 0 SO2 H H CH3 H CH3 CH3 CH 0 SO2 H H CH3 H CH3 OCH3 CH 0 SO2 H H CH3 H OCH3 OCH3 CH 0 SO2 H H CH3 H CH3 CH3 N 0 SO2 H H CH3 H CH3 OCH3 N 0 SO2 H H CH3 H OCH3 OCH3 N Table VIIIa (continued) n Q R R1 R2 R4 X Y Z m.p.( ) 1 S H H H H CH3 CH3 CH 1 S H H H H CH3 OCH3 CH 1 S H H H H OCH3 OCH3 CH 1 S H H H H CH3 CH3 N 1 S H H H H CH3 OCH3 N 1 S H H H H OCH3 OCH3 N 1 SO2 H H H H CH3 CH3 CH 1 SO2 H H H H CH3 OCH3 CH 1 SO2 H H H H OCH3 OCH3 CH 1 SO2 H H H H CH3 CH3 N 1 SO2 H H H H CH3 OCH3 N 1 SO2 H H H H OCH3 OCH3 N 1 S H H CH3 H CH3 CH3 CH 1 S H H CH3 H OCH3 OCH3 CH 1 S H H CH3 H OCH3 OCH3 CH 1 S H H CH3 H CH3 CH3 N 1 S H H CH3 H CH3 OCH3 N 1 S H H CH3 H OCH3 OCH3 N 1 SO2 H H CH3 H CH3 CH3 CH 1 SO2 H H CH3 H CH3 OCH3 CH 1 SO2 H H CH3 H OCH3 OCH3 CH 1 SO2 H H CH3 H CH3 CH3 N 1 SO2 H H CH3 H CH3 OCH3 N 1 SO2 H H CH3 H OCH3 OCH3 N 0 SO2 CH3 H CH3 H OCH3 OCH3 N 0 S H CH3 H H OCH3 OCH3 CH 0 S H Cl CH3 H OCH3 OCH3 CH 0 SO2 H Br H H OCH3 OCH3 CH 0 S H CO2CH3 CH3 H CH3 OCH3 CH 0 S H CO2CH2CH3 H H OCH3 OCH3 CH 0 SO2 H CO2CH2CH2CH3 CH3 H CH3 OCH3 N 0 S H CO2CH(CH3)2 CH3 H CH3 OCH3 N Table VIIIa (continued) n Q R R1 R2 R4 X Y Z m.p.( ) 0 S H CO2CH2CH=CH2 CH3 H CH3 OCH3 CH 0 SO2 H CO2CH2CH2OCH3 H H OCH3 OCH3 CH 0 S H CO2CH2CH2Cl CH3 H CH3 OCH3 N 0 S H SO2CH3 H H OCH3 OCH3 N 0 SO2 H SO2CH2CH2CH3 CH3 H CH3 OCH3 CH 0 S H SO2CH(CH3)2 H H OCH3 OCH3 CH 0 S H OSO2CH3 CH3 H CH3 OCH3 N 0 SO2 H OSO2CF3 H H OCH3 OCH3 N 0 S H OSO2CH(CH3)2 H H CH3 OCH3 CH 0 SO2 H SO2N(CH3)2 CH3 H CH3 OCH3 CH 0 SO2 H SO2N(CH2CH3)2 H H CH3 OCH3 N 0 SO2 H SO2N(CH3)CH2CH3 CH3 H OCH3 OCH3 N 0 S H H CH2CH3 H OCH3 OCH3 N 0 SO2 H H CH2CH2CH3 H CH3 OCH3 CH 0 S H H CH(CH3)2 H OCH3 OCH3 CH 0 S H H H H Cl OCH3 CH 0 SO2 H H CH3 H CH3 NH2 CH 0 S H H H H CH3 NHCH3 CH 0 S H H CH3 H CH3 N(CH3)2 CH 0 SO2 H H H H CH3 OC2H5 CH 0 S H H CH3 H CH3 OCH2CH3 N 0 S H H H H CH3 CH2OCH3 CH Table VIlIb EMI155.1 n Q R R1 R2 R4 X1 G m.p.( ) 0 SO2 H H H H CH3 CH2 0 SO2 H H H H OCH3 CH2 0 SO2 H H H H OCH2CH3 CH2 0 SO2 H H H H CH3 O 0 SO2 H H H H OCH3 O 0 SO2 H H H H OCH2CH3 O 0 SO2 H H H CH3 OCH3 O 0 S H H CH3 H OCH3 O 0 SO2 H H H H OCH3 O 0 S H CH3 CH3 H OCH3 O 0 SO2 H OCH3 CH3 H OCH3 O 0 S H Cl CH3 H OCH3 O 0 SO2 H Br CH3 H OCH3 O 0 S H CO2CH3 CH3 H OCH3 O 0 SO2 H SO2CH3 CH3 H OCH3 O 0 S H OSO2CH3 CH3 H OCH3 O 0 SO2 H SO2N(CH3)2 CH3 H OCH3 O 1 SO2 H H H H OCH3 O Table VIIIc EMI156.1 n Q R R1 R2 R4 X1 m.p. ( ) O SO2 H H H H CH3 O SO2 H H H H OCH3 O SO2 H H H H OCH2CH3 O SO2 H H H CH3 OCH3 O S H H CH3 H OCH3 O SO2 H H H H OCH3 O S H CH3 CH3 H OCH3 O SO2 H OCH3 CH3 H OCH3 0 S H Cl CH3 H OCH3 0 SO2 H Br CH3 H OCH3 0 S H CO2CH3 CH3 H OCH3 0 SO2 H SO2CH3 CH3 H OCH3 0 S H OSO2CH3 CH3 H OCH3 0 SO2 H SO2N(CH3)2 CH3 H OCH3 1 SO2 H H H H OCH3 table VIIId EMI157.1 n Q R R1 R2 R4 X1 m.p.( C) 0 SO2 H H H H CH3 0 SO2 H H H H OCH3 0 SO2 H H H H OCH2CH3 0 SO2 H H H CH3 OCH3 0 S H H CH3 H OCH3 0 SO2 H H H H OCH3 0 S H CH3 CH3 H OCH3 0 SO2 H OCH3 CH3 H OCH3 0 S H Cl CH3 H OCH3 0 SO2 H Br CH3 H OCH3 0 S H CO2CH3 CH3 H OCH3 0 SO2 H SO2CH3 CH3 H OCH3 0 S H OSO2CH3 CH3 H OCH3 0 SO2 H SO2N(CH3)2 CH3 H OCH3 1 SO2 H H H H OCH3 Table IXa EMI158.1 R R1 R2 X Y Z m.p.( ) H H H CH3 CH3 CH H H H CH3 OCH3 CH H H H OCH3 OCH3 CH H H H CH3 CH3 N H H H CH3 OCH3 N H H H OCH3 OCH3 N CH3 H H OCH3 OCH3 N H H CH3 CH3 CH3 CH H H CH3 CH3 OCH3 CH H H CH3 OCH3 OCH3 CH H H CH3 CH3 CH3 N H H CH3 CH3 OCH3 N H H CH3 OCH3 OCH3 N H H CH2CH3 CH3 OCH3 CH H H CH2CH2CH3 OCH3 OCH3 CH H H CH(CH3)2 CH3 OCH3 CH H OCH3 H CH3 OCH3 N H Cl H OCH3 OCH3 N H Br H CH3 OCH3 CH H C 2CH3 H OCH3 OCH3 CH H SO2CH3 H CH3 OCH3 N H OSO2CH3 H OCH3 OCH3 N H SO2N(CH3)2 H CH3 OCH3 CH Table IXa (continued) R R1 R2 X Y Z m.p.( ) H H H Cl OCH3 CH H H H OCH3 OCH2CH3 CH H H H OCH3 CH2OCH3 CH H H H OCH3 NH2 CH H H H OCH3 NHCH3 CH H H H OCH3 N(CH3)2 CH Table IXb EMI160.1 R R1 R2 X1 G m.p.( ) H H H CH3 0 H H H OCH3 0 H H H OCH2CH3 0 H H CH3 OCH3 0 CH3 H H OCH3 0 H OCH3 H OCH3 0 H Cl H OCH3 0 H Br H OCH3 0 H CO2CH3 H OCH3 0 H SO2CH3 H OCH3 0 H OSO2CH3 H OCH3 0 H SO2N(CH3)2 H OCH3 0 H H H OCH3 CH2 Table IXc EMI161.1 R R1 R2 X1 m.p.( ) H H H CH3 H H H OCH3 H H H OCH2CH3 H H CH3 OCH3 CH3 H H OCH3 H OCH3 H OCH3 H Cl H OCH3 H Br H OCH3 H CO2CH3 H OCH3 H SO2CH3 H OCH3 H OSO2CH3 H OCH3 H SO2N(CH3)2 H OCH3 Table IXd EMI162.1 R R1 R2 X1 m.p.( ) H H H CH3 H H H OCH3 H H H OCH2CH3 H H CH3 OCH3 CH3 H H OCH3 H OCH3 H OCH3 H Cl H OCH3 H Br H OCH3 H CO2CH3 H OCH3 H 5 2CH3 H OCH3 H OSO2CH3 H OCH3 H SO2N(CH3)2 H OCH3 Formulations Useful formulations of the compounds of Formulae I and I' can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1S to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions: Tabl-e X Weight Percent Active Ingredient Diluent(s) Surfactant(s) Wettable Powders 20-90 0-74 1-10 Oil Suspensions, 3-50 40-95 0-15 Emulsions, Solutions, (including Emulsifiable Concentrates) Aqueous Suspension 10-50 40-84 1-20 Dusts 1-25 70-99 0-5 Granules and Pellets 0.1-95 5-99.9 0-15 High Strength 90-99 0-10 0-2 Compositions * Active ingredient plus at least one of a Surfactant or a Diluent equals 100 weight percent. Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing. Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, New Jersey, but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, solvents Guide," 2nd Ed., Interscience, New York, 1950. Solubility under 0.1S is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at OOC. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, New Jersey, as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc. The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Patent 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, December 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff. For further information regarding the art of formulation, see for example: H. M. Loux, U.S. Patent 3,235,361, February 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41; R. W. Luckenbaugh, U.S. Patent 3,309,192, March 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; H. Gysin and E. Knusli, U.S. Patent 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; G. C. Klingman, "Weed Control as a Science", John Wiley 6 Sons, Inc., New York, 1961, pp. 81-96; and 3. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103. In the following examples, all parts are by weight unless otherwise indicated. Example 28 Wettable Powder N-[ (4 ,6-dimethylpyrimidin-2-yl)aminocarbonyl]-2,3- dihydro-2-methyl-7-benzothiophenesulfonamide, l,l-dioxide 80% sodium alkylnaphthalenesulfonate 2% sodium ligninsulfonate 2% synthetic amorphous silica 3% kaolinite 13t The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged. Example 29 Oil Suspension N-E( 4-methoxy-6-methylpyrimidin-2yl )aminocarbonyl )- 2, 3-dihydro-2-methyl-7-benzothiophenesulfonamide, l,l-dioxide 25% polyoxyethylene sorbitol hexaoleate 5% highly aliphatic hydrocarbon oil 70% The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water. Example 30 Wettable Powder N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2,3 dihydro-2-methyl-7-benzothiophenesulfonamide, l,l-dioxide 20% sodium alkylnaphthalenesulfonate 4% sodium ligninsulfonate 4% low viscosity methyl cellulose 3% attapulgite 69% The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) and packaged. Example 31 Low Strength Granule N-[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl] 2, 3-dihydro-2-methyl-7-benzothiophenesulfonamide, l,l-dioxide 0.1X attapulgite granules 99.9% (U.S.S. 20-40 mesh) The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solutior has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged. Example 32 Granule N-C(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocar- bonyl]-2, 3-dihydro-2-methyl-7-benzofuransulfonamide l,l-dioxide 80% wetting agent 1% crude ligninsulfonate salt (containing 10% 5-20% of the natural sugars) attapulgite clay 9% The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use. Example 33 High Strength Concentrate N-[(4,6-dimethoxy-l,3 ,5-triazin-2-yl)aminocarbonyl]- 2, 3-dihydro-2-methyl-7-benzothiophenesulfonamide l,l-dioxide 99% silica aerogel 0.5% synthetic amorphous silica 0.5% The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary. Example 34 Wettable Powder N-t(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3,4- dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1 dioxide 50% sodium alkylnaphthalenesulfonate 2% low viscosity methyl cellulose 2% diatomaceous earth 46% The ingredients are blended, coarsely hammermilled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging. Example 35 Granule Wettable Powder of Example 34 5% attapulgite granules 95% (U.S.S. 20-40 mesh; 0.84-0.42 mm) A slurry of wettable powder containing # 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged. Example 36 Extruded Pellet N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocar- bonyl]-3 , 4-dihydro-2H-l-benzothiopyran-8-sulfon amide, l,l-dioxide 25% anhydrous sodium sulfate 10% crude calcium ligninsulfonate 5% sodium alkylnaphthalenesulfonate 1% calcium/magnesium bentonite 59% The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled. Example 37 Aqueous Suspension N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocar bonyl]-3,4-dihydro-2H-l-benzothiopyran-8-sulfon- amide, l,l-dioxide 40% polyacrylic acid thickener 0.3% dodecylphenol polyethylene glycol ether 0.5% disodium phosphate 1% monosodium phosphate 0.5 polyvinyl alcohol 1.0% water 56.7% The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size. Example 38 Solution N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3,4- dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1 dioxide, sodium salt 5% water 95% The salt is added directly to the water with stirring to produce the solution, which may then be packaged for use. Example 39 Wettable Powder N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3,4 dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1 dioxide 90% dioctyl sodium sulfosuccinate 0.1% synthetic fine silica 9.9% The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged. Example 40 Wettable Powder N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocar- bonyl]-3,4-dihydro-2H-l-benzothiopyran-8-sulfon- amide, l,l-dioxide 40% sodium ligninsulfonate 20% montmorillonite clay 40% The ingredients are thoroughly blended1 coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged. Example 41 Oil Suspension N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3,4 dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1 dioxide 35% blend of polyalcohol carboxylic 6% esters and oil soluble petroleum sulfonates xylene 59% The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water. Example 42 Dust N-E C4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]- 3,4-dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1 dioxide 10% attapulgite 10% Pyrophyllite 80% The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous. Utility The compounds of the present invention are active herbicides. They have utility for broadspectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drivein theaters, around billboards, highway and railroad structures. Alternatively, the compounds may be used to modify plant growth. The rates of application for the compounds of the invention are determined by a number of factors, including their use as growth modifiers, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.05 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for growth modification or for situations where only short-term persistence is required. The compounds of the invention may be used in combination with any other commercial herbicide examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium types. The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow. Test A Seeds of crabgrass (Diqitaria sp.), barnyardgrass (Echinochloa crusqalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia), morningglory (Ipomoea sp.), cocklebur (Xanthium pensylvanicum), sorghum, corn, soybean, sugar beet, rice, wheat and purple nutsedge (Cyperus rotundus) tubers were planted and treated pre-emergence with the chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species, along with cotton and bush bean, were treated with a soil/foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from 0 = no injury, to 10 = complete kill. The accompanying descriptive symbols have the following meanings: A = growth acceleration; C = chlorosis/necrosis; D = defoliation; E = emergence inhibition; G = growth retardation; H = formative effects; U = unusual pigmentation; X = axillary stimulation; and 6Y = abscised buds or flowers. It will be seen that the compounds have high preand post-emergence activity at the low rates of application selected for this evaluation. A few compounds, e.g., Compounds 26, 29, 46, 47 and 52, have low activity at the very low rates of application selected for this test. It is reasonable to assume that these compounds would exhibit higher activity at higher use rates. Table A Structures Compound 1 EMI173.1 Compound 2 EMI173.2 Compound 3 EMI173.3 Compound 4 EMI173.4 Table A Structures (Continued) Compound 5 EMI174.1 Compound 6 EMI174.2 Compound 7 EMI174.3 Compound 8 EMI174.4 Table A Structures (Continued) EMI175.1 Compound 10 EMI175.2 Compound 11 EMI175.3 Compound 12 EMI175.4 Table A Structures (Continued) Compound 13 EMI176.1 Compound 14 EMI176.2 Compound 15 EMI176.3 Compound 16 EMI176.4 Table A Structures (Continued) Compound 17 EMI177.1 Compound 18 EMI177.2 Compound 19 EMI177.3 Compound 20 EMI177.4 Table A Structures (Continued) Compound 21 EMI178.1 Compound 22 EMI178.2 Compound 25 EMI178.3 Table A Structures (Continued) Compound 26 EMI179.1 Compound 27 EMI179.2 Compound 28 EMI179.3 Compound 2a EMI179.4 Table A Structures (Continued) Compound 30 EMI180.1 Compound 31 EMI180.2 Compound 32 EMI180.3 Compound 33 EMI180.4 Table A Structures (Continued) Compound 34 EMI181.1 Compound 35 EMI181.2 Compound 36 EMI181.3 Compound 37 EMI181.4 Table A Structures (Continued) Compound 38 EMI182.1 Compound 39 EMI182.2 Compound 40 EMI182.3 Compound 41 EMI182.4 Table A Structures (Continued) Compound 42 EMI183.1 Compound 43 EMI183.2 Compound 44 EMI183.3 Compound 45 EMI183.4 Table A Structures (Continued) Compound 46 EMI184.1 Compound 47 EMI184.2 Compound 48 EMI184.3 Compound 49 EMI184.4 Table A Structures (Continued) Compound 50 EMI185.1 Compound 51 EMI185.2 Compound 52 EMI185.3 Compound 53 EMI185.4 Table A Structures (Continued) Compound 64 EMI186.1 Compound 55 EMI186.2 Compound 56 EMI186.3 Compound 57 EMI186.4 Table A Structures (Continued) Compound 58 EMI187.1 Compound 59 EMI187.2 Compound 60 EMI187.3 Table A Structures (Continued) Compound 61 EMI188.1 Compound 62 EMI188.2 Compound 63 EMI188.3 Table A Structures (Continued) Compound 64 EMI189.1 Compound 65 EMI189.2 Compound 66 EMI189.3 Table A Structure No. 1 2 3 Rate kg/ha 0.05 0.05 0.05 POST-EMERGENCE Bush bean 3C,8G,6Y 6C,9G 6C,9G,6Y Cotton 3C,3H,9G 6C,9G 6C,9H Morningglory 2C,9G 3C,9H 6C,9G Cocklebur 5G 100 90 Sicklepod 1C,5G 6C,9G 4C,8H Nutsedge 4G 6C,9G 2C,8G Crabgrass 4G 6C,9G 2C,7G Barnyardgrass 2C,9H 100 100 Wild Oats 2C,6G 7C,9G 5C,9G Wheat 2C,6G 2C,9G 6C,9G Corn 2C,8H 100 3U,9G Soybean 3C,9G,5X 5C,9G 4C,9G Rice 2C,9H 5C,9G 5C,9G Sorghum 3C,9H 5C,9G 9G Sugar beet PRE-EMERGENCE Morningglory 2C,6H 8G 9G Cocklebur 8H 9H 9H Sicklepod 6G 7G 2C,7G Nutsedge 3G 10E 2C,9G Crabgrass 1C 2C,6G 2C,8G Barnyardgrass 4C,9H 3C,9H 6C,9H Wild Oats 2C,9H 4C,9H 3C,9H Wheat 1C,9G 9H 9G Corn 2C,7G 10H 5C,9H Soybean 20 9H 9H Rice 2C 10E 5C,9H Sorghum 2C,8H 5C,9G 4C,9H Sugar beet Table A (continued) Structure No. 4 5 6 Rate kg/ha 0.05 0.05 0.05 POST-EMERGENCE Bush bean 90 9C 3C,9G,6Y Cotton 6C,9G 9C 2C,5G Morningglory 10C 9C 2C Cocklebur 90 100 20 Sicklepod 4C,7H 2C,8H 2A Nutsedge 7X 3C,6G 0 Crabgrass 3C,8G 2C,8G 0 Barnyardgrass 90 9C 2C,7H Wild Oats 6H,9G 90 1C Wheat 90 100 0 Corn 100 100 2C,8H Soybean 9C 9C 2C,5H Rice 6C,9G 6C,9G 6G Sorghum 9C 100 2C,8H Sugar beet PRE-EMERGENCE Morningglory 9G 9G 2C,5H Cocklebur 9H 9H 2C,9H Sicklepod 5C,9G 5C,9G 1C Nutsedge 5G 2C,7G 0 crabgrass 3C,6G 3C,7H 0 Barnyardgrass 5C,9H 5C,9H 2C,7H Wild Oats 4C,9H 4C,9H 2C,8G Wheat 2C,9G 2C,9G 1C Corn 5C,9G 10H 4C,7H Soybean 9H 9H 1H,1A Rice 10E 10E 4C,7H Sorghum 7C,9H 6C,9H 4C,8H Sugar beet Table A (continued) Cmpd. 7 Compound 8 Rate kg/ha 0.05 0.4 0.05 POST-EMERGENCE Bush bean 5C,9G,6Y 90 90 Cotton 5C,9G 90 90 Morningglory 4C,9G 100 90 Cocklebur 3C,9G 90 100 Sicklepod 3C,8G 10C 9C Nutsedge 9G 5C,9G 9G Crabgrass 4C,9G 6C,9G 5C Barnyardgrass 90 90 50 Wild Oats 90 60,9G 60 Wheat 90 90 60 Corn 4U,9G 3U,9C 5U Soybean 4C,9G 90 90 Rice 9C 5C,9G 5C Sorghum 5C,9G 5C,9G 4C Sugar beet 9C - - PRE-EMERGENCE Morningglory 9G 90 9G Cocklebur 3C,8H 9H 9H Sicklepod 3C,7G 9G 9G Nutsedge 3C,8G 10E 10E Crabgrass 3C,7G 10E 5C,9G Barnyardgrass 3C,8H 9H,7C 6C,9H Wild Oats 5C,9G 6C,9H 6C,9H Wheat 3C,9G 10E 10E Corn 2C,9G 10H 10E Soybean 3C,6H 9H 9H Rice 10E 10E 10E Sorghum 3C,9G 10E 6C,9H Sugar beat 4C,9G 10E 10E Table A (continued) Compound 9 Compound 10 Rate kg/ha 0.4 0.05 0.4 0.05 POST-EMERGENCE Bush bean 90 6C,9G,6Y 90 6C,9G,6Y Cotton 9C 10C 4C,9G 5C,9G Morningglory 10C 10C 4C,9G 3C,7H Coclebur 9C 9C 5C,9G 4C,8G Sicklepod 9C 9C 5C,9G 3C,7G Nutsedge 90 9G 2C,8G 0 crabgrass 7C,9G 7C,9G 4C,9G 2C,8G Barnyardgrass 9C 7C,9G 9C 4C,9H Wild Oats 6C,9G 6C,9G 9C 6C,9G Wheat 7C,9G 6C,9G 6C,9G 9C Corn 90 90 7C,9G 4U,9G Soybean 90 90 90 3C,7G Rice 6C,9G 5C,9G 5C,9G 4C,9G Sorghum 9C 5C,9G 2C,9G 2C,9G Sugar beet PRE-EMERGENCE Morninglory 9H 5 C,9G 9G 2C,5G Cocklebur 9H 9H 9H 5H Sicklepod 9G,4C 5C,9G 9G 7G Nutsedge 10E 10E 2G 1C,3G Crabgrass 6C,9G 5C,9G 2C,6G 2G Barnyardgrass 6C,9H 5C,8H 3C,9H 4G Wild Oats 6C,9H 5C,9H 3C,8H 2C,6G Wheat 6C,9H 5C,9H 5C,9H 9G Corn 10E 5C,9G 5C,9H 2C,8G Soybean 9H 9H 2C,8H 1C,1H Rice 10E 10E 10E 10E Sorghum 10E 6C,9H 10H 9H Sugar beet 10E 10E 1CE 6G Table A (continued) Cmpd. 11 Cmpd. 12 Cmpd. 13 Cmpd.14 Rate kg/ha 0.4 0.05 0.05 0.05 POST-EMERGENCE Bush bean 90 90 90 90 Cotton 4C,8G 5C,9G 6C,9G 5C,9G Morningglory 90 5C,9G 90 90 Cocklebur 4C,9G 90 90 100 Sicklepod 5C,9G 4C,9G 9C 9C Nutsadge 7G 4C,8G 10C 6C,9G Crabgrass 4C,9G 5C,9G 9C 7C,9G Barnyardgrass 4C,9H 5C,9H 6C,9H 9C Wild Oats 6C,9G 90 90 90 Wheat 4C,9G 90 90 90 Corn 3C,9G 5U,9C 100 9C Soybean 90 90 9C 90 Rice 5C,9G 5C,9G 6C,9G 6C,9G Sorghum 2C,9G 5U,9C 90 90 Sugar beet - 90 90 90 PRE-EMERGENCE Morningglory 9G 9G 9C 9C Cocklebur 9H 9H 9H 9H Sicklepod 9G 5C,9G 2C,9G 9G Nutsedge 5G 10E 10E 10E Crabgrass 2C,6G 5C,9G 6C,9H 6C,9G Barnyardgrass 3C,9H 4C,9H 6C,9H 6C,9H Wild Oats 2C,8H 4C,8G 6C,9H 6C,9H Wheat 9G <RTI ID=194.8> 9H 9H 9H Sorn 2O,9G 5C,9H 9H 9H Soybean 2C,8H 8H 9H 9H Rice 10E 10E 10E 10E Sorghum 4C,9H 5C,9H 10H 6C,9H Sugar beat 10E 10E 10E 10E Table A (continued) Compound 15 Compound 16 Rate kg/ha 0.4 0.05 0.4 0.05 POST-EMERGENCE Bush bean 90 90 90 6C,9G,6Y Cotton 4C,9G 5C,9G 4C,9G 4C,9G Morningglory 9C 4C,8H 5C,9G 4C,9G Cocklebur 9C 4C,9H 9C 5C,9G Sicklepod 9C 5C,9G 9C 5C,9G Nuatsedge 3C,9G 3C,9G 9G 2C,8G Crabgrass 9C 4C,8G 7C,9G 2C,8G Barnyardgrass 90 90 90 90 Wild Oats 90 90 90 90 Wheat 90 8U,9G 90 90 Corn 100 90 90 7U,9C Soybean 6C,9G 5C,9G 6C,9G 5C,9G Rice 90 90 90 90 Sorghum 9C 6C,9G 9C 6C,9G Sugar beet 90 90 90 90 PRE-EMERGENCE Morningglory 90 9G 9C <RTI ID=195.6> 9G Cocklebur 9H 9H 9H 2C,8H Sicklepod 9G 9G 90 9G Nutsedge 10E 2G 10E 5C,9G Crabgrass 5C,9G 7G 7C,9G 2C,6G Barnyardgrass 6C,9H 3C,8G 6C,9H 5C,8G Wild Oats 6C,9H 4C,9H 6C,9H 5C,9H Wheat 10E 5C,9H 6C,9H 9H Corn 10E 3C,9H 10H 5C,9H Soybean 8H 8H 9H 8H Rice 10E 10E 10E 10E Sorghum 7C,9H 5C,9H 7C,9H 5C,9H Sugar beet 10E 10E 10E 10E Table A (continued) Cmpd. 17 Cmpd. 18 Cmpd. 19 Rate kg/ha 0.05 0.05 0.05 POST-EMERGENCE Bush bean 1C 10D,9G,6Y 9D,9G,6Y Cotton 1C,2H 4C,9G 4C,9G Morningglory 2C,3G 2C,8H 3C,9G Cocklebur 2G 2C,9H 5C,9G Sicklepod O 2C,8H 6C,9G Nutsedge 0 2C,8G 90 Crabgrass O 3C,9G 9C Barnyardgrass 3G 90 90 Wild Dats O 2C,9G 6C,9G Wheat O 100 90 Corn O 5C,9G 10C Soybean O 3C,9G 5C,9G Rice 5G 5C,9G 9C Sorghum 1C 5C,9G 100 Sugar beet 2G 90 90 PRE-EMERGENCE Morningglory O 9H 5C,9H Cocklebur O 9H 9K Sicklepod O 8G 9G Nutsedge O 2C 10E Crabgrass O 2C,3H 2C,6G Barnyardgrass O 5C,9H 5C,9H Wild Oats O 5C,9G 5C,9G Wheat O 100 6C,9H Corn O 2C,9H 9C Soybean O 3C,8H 9H Rice O 5C,9H 10E Sorghum O 5C,9H 5C,9H Sugar beet 20 5C,9G 90 Table A (continued) Cmpd. 20 Cmpd. 21 Compound 22 Rate kg/ha 0.05 0.05 2.0 POST-EMERGENCE Bush bean 4C,9G,6Y 6C,8G,6Y 3C,5G,6Y Cotton 3C,4G 4C,8G 4C,8G Morningglory 5C,8H 4C,9H 4C,8G Cocklebur 5C,9H 4C,8H 4C,9G Sicklepod 2C,4H 3C,3H 3G Nuts edge 20 0 2G Crabgrass 20,7G 2C,8G 2G Barnyardgrass 90 90 0 Wild Oats 80 90 0 Wheat 90 100 5G,5X Corn 7U,9C 90 3H Soybean 4C,8G,5X 2C,9G 1C,5G Rice 6C,9G 5C,9G 2C,5G Sorghum 5U,9C 90 2C,7H Sugar beet 5C,9G 90 PRE-EMERGENCE Morningglory 3C,8H 9G 2H Cocklebur 9H 5C,9G 8H Sicklepod 2C,7G 2C,3H 1C Nutsedge O O O Crabgrass 1H o 0 Barnyardgrass 2C,5G 6H 4G Wild Oats 2C,9G 2C,9G 5G Wheat 2C,9G 2C,9G 4G Corn 3C,9H 5C,9H 5C,8H Soybean 2C,3H 1C,1H 2G Rice 10E 10E O Sorghum 5C,9G 5C,9H 2C,7G Sugar beet 1C 4C,8G Table A (continued Cmpd. 23 Cmpd. 24 Rate kg/ha 0.05 0.05 POST-EMERGENCE Bush bean 3C,9G,6Y 7C,9G,6Y Cotton 3C,4H,9G 4C,4H,9G Morningglory 3C,9G 3C,8G Cocklebur 3C,9G 3C,9G Sicklepod 2C,5G 3C,8H Nutsedge 3G 3E Crabgrass 0 2H Barnyardgrass 2C,5H 6H Wild Oats 2G 0 Wheat 8G 4G Corn 3C,9G 2C,9G Soybean 3C,9G 3H,9G Rice 3C,9G 6C,9G Sorghum 3C,9G 9G Sugar beet - PRE-EMERGENCE Morningglory 2C,8H 2C,8G Cocklebur 8H 9H Sicklepod O 3C,8H Nutsedge O 2C,6G Crabgrass 2C,4G 1C Barnyardgrass 6H 2C,7H Wild Oats <RTI ID=198.6> 2G 2C,8H Wheat 7G 2C,9G Corn 2C,9H 2C,8G Soybean 2C,6G 2C,6H Rice 3C,7H 9H Sorghum 4C,8H 3C,9G Sugar beet - Table A (continued) Compound 25 Compound 26 Rate kg/ha 0.4 0.05 2.0 0.05 POST-EMERGENCE Bush bean 5C,9G,6Y 2C,2H 6C,9G,6Y 1C,3G Cotton 4C,8G 1C 2C,3H,8G 1C Morningglory 30 1C 5C,9H 1C Cocklebur 2C,5H 1C 2C,5H O Sicklepod 3C 1C 3C,4H 1C Nutsedge 2G 0 0 0 Crabgrass 2G O 1C,3G O Barnyardgrass 2C,7H O 3C,9H O Wild Oats 9G,7X 4G,5X 5C,9G O Wheat 10C 1C,5G 9C O Corn 90 2C,7H 6U,9C 0 Soybean 2H,5G 1C,1H 3C,5G O Rice 9C 2U,9G 90 0 Sorghum 9C 2C,9H 2U,9G O Sugar beat - - - PRE-EMERGENCE Morningglory 2C,4G O 8G O Cocklebur 1H O 8H 7G Sicklepod O O 8G 2G Nutsedge O 0 8G 2G Crabgrass O 0 2G 2G Barnyardgrass 2G 0 2C,8G 2G Wild Oats 5H 0 2C,8G 0 Wheat 8G O 2C,9G O Corn 3C,9G 2C,5G 2C,9G O Soybean O 1H 1C,2H 2G Rice 9G,9E 2G 5C,7G O Sorghum 2C,9G 1C,4G 3C,9G O Sugar beet - - - Table A (continued) Cmpd. 27 Cmpd.28 Cmpd.29 Rate kg/ha 0.4 0.4 0.4 POST-EMERGENCE Busn bean 1C 4C,9G,6Y 9D,9G,6Y Cotton 1C 5C,9G 3C,9G Morningglory O 4C,8H 4C,6H Cocklebur 1C 5C,9G 3C,9G Sicklepod O 2C,3H 3C,8G Nutsedge O 2G 2G Crabgrass 2G 4G 1C,3G Barnyardgrass 1C 2C,8H 100 Wild Oats O 0 3G Wheat O 3G 5G Corn O 3C,7G 2C,9H Soybean O 4C,8G 5C,9G Rice O 4C,9G 6C,9G Sorghum 20 5C,9G 9G Sugar beet - - RE-FMERGENCE Morningglory O 9G 9G Cocklebur - 9H BH Sicklepod O 2C,8G 9G Nutsedge 10E 10E 10E Crabgrass 1C 2C 4G Barnyardgrass 1C 2C,9H 5C,9H Wild Oats 2G 2C,6G 2C,6G Wheat C 9G 5H Corn 2C,5G 2C,9G 2C,9G Soybean O 2C,6H 9H Rice 1C 10E 10E Sorghum 2C,3G 5C,9H 10H Sugar beet - - Table A (continued) Cmpd. 30 Cmpd. 31 Cmpd. 32 Cmpd. 33 Rate kg/ha 0.4 0.05 0.05 0.05 POST-EMERGENCE Bush bean 4C,9G,6Y 9C 9C 5C,9G,6Y Cotton 5C,9G 4C,9G 4C,9G 4C,8G Morningglory 2C 5C,9G 9C 4C,7G Cocklebur 20 90 lOC 10C Sicklepod 20 5C,9G 9C Nutsedge 0 5C,9G 90 2G Crabgrass 2G 9C 6C,9G 1C,3G Barnyardgrass 2H 90 90 4C,9H Wild Oats 3G 90 90 2C,8G Wheat 2G 90 90 8G Corn 4C,8H 9C 9C 5C,9G Soybean 5C,6G 5C,9G 9C 5C,9G Rice 3C,9G 9C 9C 6C,9G Sorghum 2C,9G 90 90 Sugar beet - 9C 5C,9G 5C,9G PRE-EMERGENCE Morningglory 2G 9G 100 9C Cocklebur 9H 8H 9H 9H Sicklepod 2C,6G 9C 3C,9G 8G Nutsedge O 9G 10E 2G Crabgrass 2G 4C,8G 5C,9G 2C,4G Barnyardgrass 2C,7G 9C 9H 3C,6H Wild Oats 3C 4C,9G 5C,9G 2C,9G Wheat 2C,9H 9C 10C 2C,8G Corn 2C,9H 9C 5C,9G 3C,9H Soybean 2C,3H 4C,8H 3C,8H 2C,7H Rice 10E 10E 10E 10E Sorghum 5C,9G 9H 6C,9H 3C,9H Sugar beet - 3C,9G 5C,9G 10C Table A (continued) Cmpd. 34 Cmpd. 35 Cmpd. 36 Cmpd.37 Rate kg/ha 0.05 0.05 0.05 0.05 POST-EMERGENCE Bush bean 5C,9G,6Y 4C,6G,6Y 5C,9G,6Y 4C,8G,6Y Cotton 4C,8H 4C,7H 4C,9G 4C,7H Morningglory 3C,7G 4C 3C,8G 4C,9G Cocklebur 9C 3C,8H 9C 3C,9H Sicklepod 3C,8G 2C 4C,6H 2C Nutsedge 3G 2G 4C,9G 0 Crabgrass 3G 1C 2C,8G 1C Barnyardgrass 3C,9H 4C,9H 9C 3C,9H Wild Oats 3C,9G 2C,6G 9C 1C,3G Wheat 2C,9G,5X 2C,8G 9C 1C,5G Corn 3U,9G 2C,8H 4U,8C 2C,9G Soybean 3C,9G 2C,8G 4C,9G 4C,9G Rice 5C,9G 5C,9G 6C,9G 6C,9G Sorghum 2C,9G 4C,9H 9C 2C,9G Sugar beet 9C 4C,7G 9C 4C,8G PRE-EMERGENCE Morningglory 9G 2C,8H 9G 3C,8G Cocklebur 9H - 3H 9H Sicklepod 9G 4G 2C,4G 2C,5G Nutsedge 2C 4G 10E O Crabgrass 1C,2G 2G 2G 1C Barnyardgrass 3C,8H 3C,9H 4C,9H 5C,8H Wild Oats 2C,6G 2C,8G 2C,9G 3C,7G Wheat 1C,5G 2C,9G 2C,9H 7G Corn 2C,9H 2C,9H 2C,9H 2C,9G Soybean 2C,6G 2C,3H 2C,3H 3C,6H Rice 10E 5C,9H 10E 10E Sorghum 4C,9G 3C,9H 2C,9H 2C,9H Sugar beet 10E 9G 4C,9G 4C,9G Table A (continued) Cmpd. 38 Cmpd. 39 Cmpd. 40 Cmpd. 41 Rate kg/ha 0.05 0.4 0.4 0.4 POST-EMERGENCE Bush bean 4C,9G,6Y 5C,9G,6Y 90 20 Cotton 2C,2H 5C,9G 5C,9G 2C,2H Morningglory 4C,8H 10C 4C,8G 1C Cocklebur 4C,9H 10C 9C 3C,7H Sicklepod 2C,3H 90 90 2C Nutsedge 0 9G 4C,9G 2G Crabgrass 2C 5C,9G 5C,9G O Barnyardgrass 4C,8H 5C,9H 9C O Wild Oats 3C,9G 5C,9H 4C,9G O Wheat 2C,5G 4C,9G 1C,7G O Corn 1U,9G 3U,9G 4U,9G O Soybean 3C,9G 90 90 2G Rice 5C,9G 5C,9G 5C,9G O Sorghum 2C,9G 2U,9G 3C,9G O Sugar beet 3C,5H 9C 5C,9G PRE-EMERGENCE Morningglory BG 9G 9G Cocklebur 8H 9H 9H 8H Sicklepod 7G 9G 9G 5G Nutsedge 2G 10E 10E 5G Crabgrass 1C 10E 5C,9G O Barnyardgrass 4C,8H 5C,9H 5C,9H 3C Wild Oats 2C,8G 5C,9H 4C,8G O Wheat 2C,7G 9H 8G O Corn 2C,9G 9H 3C,9G 3C Soybean 2C,4H 9H 9H 20 Rice 10E 10E 10E 2C,5G Sorghum 2C,9H 10E 3C,9G 1C Sugar beet 3C,9G lOE lOE Table A (continued) Cmpd. 42 Rate kg/ha 0.4 POST-EMERGENCE Bush bean 4C,4G,6Y Cotton 2C Morningglory O Cocklebur 3C,8G Sicklepod 2C Nut sedge O Crabgrass O Barnyardgrass O Wild Oats O Wheat O Corn O Soybean 2C,4G Rice O Sorghum O Sugar beet PRE-EMERGENCE Morningglory 2G Cocklebur 8H Sicklepod 5G Nutsedge 0 Crasgrass O Barnyardgrass 2C Wild Oats O Wheat 1C Corn 2C Soybean O Rice 3C,8H Sorghum 3C,5H Sugar beet Table A (continued) Cmpd. 43 Cmpd. 44 Cmpd. 45 Cmpd. 46 Rate kg/ha 0.05 0.05 0.05 0.05 POST-EMERGENCE Bush bean 5C,8G,6Y 90 90 4C,7G,6Y Cotton 2C,5G 90 90 1C Morningglory 1C,4G 1C,4G 4C,8H 1C Cocklebur 1C 2C,8H 90 1C Sicklepod O 4C,9G 9C O Nutsedge 1C,4G 3C,7G 10C 2G Crabgrass 2G 3C,7G 2C,6G O Barnyardgrass 2C,6H 3C,9H 10C O Wild Oats O 2C,9H 5G O Wheat O 1C,9G 5G O Corn 1C,4H 2C,8G 2C,9G O Soybean 2C,4H 9C 9C 3C,3H Rice 2C,4G 3C,9G 9G 1C,4G Sorghum 3C,8H 3C,9G 2C,9G 1C,3G Sugar beet 1C,5G 4C,7G - 4C,9G PRE-EMERGENCE Morningglory O 9G 9G 1C Cocklebur - - - 0 Sicklepod 3H 9G 9G 1C Nutsedge 9G 10E 10E O Crabgrass 2G 3G 8G 2G Barnyardgrass 1C 5C,9H 9H 1C Wild Oats 1C 3C,8H 3C,8G O Wheat 1C,5G 2C,9H 8G O Corn 1C,5G 9H 2C,9G O Soybean O 8H 7H O Rice 2G 10E 9H O Sorghum 3C,5G 10H 5C,9H 2G Sugar beet 2G 10E - 1C Table A (continued) Cmpd. 17 Cmpd. 48 Cmpd. 49 Cmpd.50 Rate kg/ha 0.05 0.05 0.05 0.05 POST-EMERGENCE Bush bean 90 90 90 90 Cotton 2C,8G 9C 4C,8G 3C,9G Morningglory 3C,6G 3C,9G 2C,8H 3C,9G Cocklebur 3C,6G 90 90 100 Sicklepod 5C,9G 5C,9G 5C,9G 9C Nutsedge O 1C,3G 4C,8G 90 Crabgrass 2C,5G 1C,4G 4C,9G 9C Barnyardgrass 2C,9H 3C,9H 9C 9C Wild Oats O 1C,3G 2C,9G 9C Wheat 2G 4G 2C,9G 90 Corn lU,9H 1C,9G 100 100 Soybean 90 90 5C,9G 90 Rice 3C,9G 5C,9G 5C,9G 9C Sorghum 1C,9G 1C,9G 90 100 Sugar beet 2C,9G 3C,9G 2C,8H 9C PRE-EMERGENCE Morningglory 9G 9G 100 9H Cocklebur 9H 9H 9H 9H Sicklepod 8G 9G 2C,9G 9G Nutsedge 9G 8G lOE 10E Crabgrass 2G O 1C 8G Barnyardgrass 3C 2C,7H 2C,9H 9H Wild Oats 2C,4G 2C,6G 2C,9H 6C,9G Wheat 6G 6G 5C,9H 100 Corn IC,9G 2U,9G 5C,9H 1OH Soybean 7H 9H 2C,8H 9H Rice 10E 10E 10E 10E Sorghum 2C,8H 2C,9H 3C,9H 6C,9H Sugar beet 10E 10E 9G 10E Table A (continued) Cmpd. 51 Cmpd. 52 Rate kg/ha 0.05 0.4 POST-EMERGENCE Bush bean 90 5C,8G,6Y Cotton 3C,9G 4C,3H,9G Morningglory 4C,3G 1C,2H Cocklebur 10C 5G Sicklepod 4C,8H 2C,8H Nutsedge 90 9G Crabgrass 5C,9G O Barnyardgrass 9C 2C,8H Wild Oats 9C 0 Wheat 90 0 Corn 10C 2C,6G Soybean 9C 2C,9G Rice 90 6G Sorghum 10C 2C,9H Sugar beet 90 PRE-EMERGENCE Morningglory 8H 6G Cocklebur 9H 8H Sicklepod 9G 5G Nutsedge 10E 2C,8G Crabgrass 8G 1C Barnyardgrass 9H 3C,6H Wild Oats 5C,9G 2C,6C Wheat 10H O Corn 5C,9H 2C,7G Soybean 2C,8H 2H Rice 10E 5G Sorghum 9H 2C,5G Sugar beat 10E Table A (continued) Cmpd. 53 Cmpd. 54 Cmpd. 55 Rate, kg/ha 0.05 0.05 0.05 POST-EMERGENCE Bush bean 3C,6Y 5C,9G,6Y 5C,9G,6Y Cotton 1C 2C,5G 2C,4G Morninnglory 2C 5C,9G 5C,9G Cocklebur 1C 5C,9G 5C,9G Sicklepod 1C 4C,8G 5C,9G Nutsedge O 1C 1C,5G Cracgrass O 4C,6G 5C,9H Barnyardgrass 1C,3H 5C,9H 5C,9H Wild Oats O 5C,9H 5C,9G Wheat 1C 2C,9G 4C,9G Corn O 3C,9G 4C,9G Soybean 1C 4C,9G,5X 3C,8G Rice 2G 5C,9G 6C,9G Sorghum 1C,4G 4C,9G 1C,9G Sugar beet 2C,4G 4C,8G 9C PRE-EMERGENCE Morningglory O 4C,6H 9G Cocklebur O 9H 9H Sicklepod O 3H 2C,8G Nutsedge O 1C 2C,3G Crabgrass O 2C,4G 2C,3G Barnyardgrass O 2C,5G 3C,9H Wild Oats O 4C,6G 5C,9G Wheat O 3C,9G 2C,8H Corn O 4C,8G 3C,9G Soybean O 3C,2H 3C,3H Rice O 2C,3G 10E Sorghum O 5C,9H 5C,9G Sugar beet O 2C,4G 10E Table A (continued) Cmpd.56 Cmpd.56 Cmpd. 57 Rate, kg/ha 0.05 0.4 2 POST-EMERGENCE Bush bean 5C,8G,6Y 4C,8G,6Y 1C Cotton 2C,6G 4C,8G 2C Morningglory 2C,5G 4C,5H 3C Cocklebur 1H 4C,8H 20 Sicklepod O 1C O Nutsedge O 0 0 Crabgrass 2G 3C,8G 2C,3G Barnyardgrass 8H 5C,8H 2C Wild Oats 2C,8G 4C,8G O Wheat 2C,8G 4U,9G 0 Corn 3C,9G 3U,9G 3C,4G Soybean 2C,3H 2C,7G 2C Rice 5C,9G 5C,9G 3C Sorghum 3C,9G 2C,9G 3C,5G Sugar beet 2C,3H 3C,3H 3C PRE-EMERGENCE Morningglory 2C 4C,6H 2C,7H Cocklebur - 9H 8H Sicklepod 0 3C,6H 30 Nutsedge O 0 2C,7G Crabgrass O 1C,5G 2C,4G Barnyardgrass 1C 2C,8H 3C,8H Wild Oats 1C,4G 4C,9G 4C,8G Wheat 1C,5G 3C,9G 2C,8G Corn 2C,4G 2C,9G 3C,9H Soybean 2G 2C,3H 2C,2H Rice 2C,4G 10E 4C,9H Sorghum 2C,8G 9H 4C,9G Sugar beet 3C,8G 7G 3C,9G Table A (continued) Cmpd. 58 Cmpd. 59 Rate, kg/ha 2 2 POST-EMERGENCE Bush bean 0 1C Cotton 1C 4C,4H Morningglory 1C 2C,2H Cocklebur 1C 1C,5G Sicklepod O 1C Nutsedge O O Crabgrass 2C,4G 3C,6G Barnyardgrass 1C 3C,9H Wild Oats O 2C,8G Wheat O 2C,7G Corn O 2C,8H Soybean 1C O Rice 2C,5G 2C,8G Sorghum 2C,5H 2C,9G Sugar beet 1C 1C PRE-EMERGENCE Morningglory 8G 8H Cocklebur 8H 9H Sicklepod 2C,6G O Nutsedge 8G 3G Crabgrass 2G O Barnyardgrass 2C,8H 3C,9H Wild Oats 2C,9G 2C,5G Wheat 2C,9G 2C,9G Corn 2C,8G 2C,8G Soybean 2C,2H 1C Rice 5C,9H 9H Sorghum 2C,9G 3C,9G Sugar beet 4C,8G 5G Table A (continued) Cmpd. 60 Rate, kg/ha 2 POST-EMERGENCE Bush bean 0 Cotton 1C Morningglory O Cocklebur 2G Sicklepod O Nutsedge O Crabgrass O Barnyardgrass O Wild Oats O Wheat O Corn 2G Soybean O Rice O Sorghum 1C Sugar beet 0 PRE-EMERGENCE Morningglory 2C.7H Cocklebur 9H Sicklepod 1C Nutsedge lOE Crabgrass 1C Barnyardgrass 2C,3H Wild Oats O Wheat 3G Corn 3C,6H Soybean O Rice 8H Sorghum 2C,9G Sugar beet 4G Table A (continued) Compound 61 Compound 62 Rate (kg/ha) 0.05 0.05 POSTEMERGENCE Bush bean 5C, 9G, 6Y 9C Cotton SC, 9G 5C, 9G Sorghum 6C, 9G 9C Corn 3U, 9G 100 Soybean 5C,9G 5C,9G Wheat 2C, 9G 9C Wild Oats 2C, 9G 3C, 9G Rice 4C, 9G 9C Barnyardgrass 3C,8H 9C Crabgrass 2C, 9G 9C Morningglory SC, 9G SC, 9G Cocklebur 9C 100 Sicklepod 3C,8G 5C,9G Nutsedge 9C - 9C Sugar beet 9C 9C PREEMERGENCE Sorghum 2C,9H 5C,9H Corn 2C,6H 5C,9G Soybean 1C, 2C,8H Wheat O 5C,9G Wild Oats, O 2C,8G Rice 8H 10E Barnyardgrass 1C 5C, 9G Crabgrass O 2C,9G Morningglory 2C, 8H 8G Cocklebur 8H 8H Sicklepod 4G 5C, 9G Nutsedge O lOE Sugar beet 9G 100 Table A (continued) Compound 63 Compound 4 Rate (kg/ha) 0.05 0.05 POSTEMERGENCE Bush bean 9D, 9G, 6Y 5C, 9G, 6Y Cotton 4C, 7G 2G Sorghum 3C, 9G SC, 9G Corn 9C 9C Soybean 4C, 9G 5C, 9G Wheat 9C 9C Wild Oats 9C 9C Rice 4C, 9G SC, 9G Barnyardgrass 9C 9C Crabgrass 2C, 9G 5C, 9G Morningglory 1C, 3G 2C, 7G Cocklebur 2C,7H 5C,9G Sicklepod 2C,5H 3C,8G Nutsedge 2G 2C,9G Sugar beet 1C 5G PREEMERGENCE Sorghum 5H 1C,9G Corn 2C,9H 2C,9G Soybean 2G 2C, 6H Wheat 2C, 8G 9H Wild Oats 2G 2C,9G Rice 9H 10E Barnyardgrass O 50, 9H Crabrass O 5G Morningglory 0 7G Cocklebur 8G 9H Sicklepod 1C,5G 8G Nutsedge 0 10E Sugar beet 7G 9G Table A (continued) Compound 65 Compound G6 Rate (kg/ha) 0.05 0.05 POSTEMERGENCE Bush bean 5C, 9G, 6Y 90 Cotton -- 4C, 9G Sorghum 6C,9G 5C,9G Corn 6C,9H 9C Soybean 5C,9H 4C,9G Wheat 9C 9C Wild Oats 6C,9H 5C,9G Rice 6C,9G 6C,9G Barnyardgrass 5C,9H 9C Crabgrass 2C 9C Morningglory 4C,9H 4C,9G Cocklebur 4C,9H 10C Sicklepod 1C 3C,9G Nutsedge 2C,9G 6C,9G Sugar beet 4C,9H 5C,9G PREEMERGENCE Sorghum 3C,9G 5C,9H Corn 3C, 7H 3C, 9G Soybean 3C,3H 3C,7G Wheat 3C,9H 3C,9H Wild Oats 2C,9G 3C,9H Rice 5C, 9H lOE Barnyardgrass 1C 2C,9H Crabgrass 2G 5C,9G Morningglory 9G 9G Cocklebur 3C,7H 9H Sicklepod 2C 1C,9G Nutsedge O 10E Sugar beet 3C,7H 5C,9G

Claims: Claims: 1. A compound of the formula: EMI215.1 wherein O is EMI215.2 and Q is 0, S or S02; R is H or CH3; R1 is H, CH3, OCH3, C1, Br, C02R5, 502R6, OS02R7 or SO2NR8R9; R2 and R3 are independently H or C1-C3 alkyl; R4 is H or CH3; R5 is C1-C3 alkyl, CH2CH=CH2, CH2CH2OCH3 or CH2CH2Cl; R6 is C1-C3 alkyl; R7 is C1-C3 alkyl or CF3; R8 and R9 are independently C1-C2 alkyl; A is EMI216.1 G is O or CH2; X is CH3, OCH3 or Cl; X1 is OK3, OCH3 or OC2H5; Y is CH3, OCH3, OC2H5, CH2OCH3, C2H5, NH2, NHCH3 or N(CH3)2; Z is CH or N; and their agriculturally suitable salts provided that 1) when X is C1, then Z is CH and Y is OCH3, NH2' NHCH3, N(CH3)2 or OC2H5; 2) the total number of carbon atoms in R2 and R3 are less than or equal to 3; 3) In Structure J2 when R2 and R3 is other than H, -then R4 is H; 4) In Structure J3 when R2 is other than H, then R4 is H; 5) when Q is 5, then R1 is not SO2NR8R9; 6) In Structures J3 and a6, Q may not be O; and 7) In Formula J7, R1 is not OK3. 2. Compounds of Claim 1 where J is J1. 3. Compounds of Claim 1 where J is J2. 4. Compounds of Claim 1 where J is J3. 5. Compounds of Claim 1 where J is J4. 6. Compounds of Claim 1 where J is J5. 7. Compounds of Claim 1 where J is J6. 8. Compounds of Claim 1 where J is J7. 9. Compounds of any of Claims 2 to 8 where R is H. 10. Compounds of Claim 9 where R1 is H. 11. Compounds of claim 10 where A is EMI217.1 and X is OCH3 or C1. 12 Compounds of Claim 11 where Y is CH3 or OCH3. 13. The compound of Claim 1 which is N-E(4- methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-3,4- dihydro-2H-l-benzothiopyran-8-sulfonamide, 1,1dioxide. 14. The compound of Claim 1 which is N-[(4,6dimethoxypyrimidin-2-yl)aminocarbonyl]-3,4-dihydro-2H1-benzothiopyran-8-sulfonamide, 1,1-dioxide. 15. The compound of Claim 1 which is N-t(4- methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]3,4-dihydro-2H-1-benzothiopyran-8-sulfonamide, 1,1dioxide. 16. A compound of the formula: EMI218.1 wherein J' is EMI218.2 J'1 J'2 J'3 and Q is O, S or SO2: is O, S, SO or SO2; R is H or CH3 R1' is H, CH3, OCH3, C1, Br, NO2, CO2R7 or SO2NR8R9; SO2R6, OSO2R7 or SO2NR8R9, R2 is H or C1-C3 alkyl; R3 is H or CH3 R4 is H or CH3 R4 is H, C1, OK3, CF3, OCH3 or Br; R5 is C1-C3 alkyl, CH2CH=CH2, CH2CH2OCH3 or CH2CH2Cl; R6 is C1-C3 alkyl; R7 is C1-C3 alkyl or CF3; R'8 and R9 are independently C1-C2 alkyl; R10 is H, C1, Br or C1-C3 alkyl; R11 is H, CH3, Cl or Br; W is O or S; A' is EMI219.1 G is O or CH2; X' is H, CH3, OCH3 or C1; X1 is CH3, OCH3 or OC2H5; X2 is CH3, C2H5 or CH2CF3; ; Y is CH3, OCH3, OC2H5, CH2OCH3, NH2, NHCH3, N(CH3)2, CH(OCH3)2, EMI219.2 C2H3, CF3, CH2=CHCH2O, SCH3, HC#CCH2O or CF3CH2O; Y2 is C2H3, CH3, OCH3, OC2H5, SCH3 or SC2H5; and Z' is CH, N, CCH3, CC2H5, CCl or CBr; and their agriculturally suitable salts provided that 1) In Structures J1' and J2', when Q1 is 0 and R1' is other than H, C1, Br or N02, then at least one of R2 and R3 is alkyl, and when Q is S, then R1' cannot be NO2; 2) In Structure J3', when R1 is N02 or SO2NR8R9, then R10 is C1-C3 alkyl and R11 is OH3; 3) when X' is C1, then Z' is CH and Y' is OCH3, NH2, NHCH3 or N(CH3)2; 4) when Q1 is SO, then W is 0; and 5) when R4 is other than H, then 1' is H. 17. Compounds of Claim 16 where 3' is J1' and R4 is H. 18. Compounds of Claim 16 where J' is J2. 19. Compounds of Claim 17 or 18 where W is O and R is H. 20. Compounds of Claim 19 where R1' is H, C1, CH31 OCH3, C02R5 or S02R6. 21. Compounds of Claim 43 where R4 (if present) and R1 are H and R2 and R3 are independently H or CH3. 22. Compounds of Claim 16 where J' is J3, W is O and R is H. 23. Compounds of Claim 22 where R11 is H and R1 is H, C1, CH3 OCH3, CO2R5 or SO2R6 and SO2NHC(W)NRA' is bonded to the 7-position. 24. Compounds of Claim 23 where R1' is H and R10 is H or CH3. 25. Compounds of Claims 21 or 24 where A' is EMI220.1 Z' is CH or N; and X' is CH3, OCH3 or C1. 2G Compounds of Claim 57 where Y' is CH3, OCH3, CH2OCH3 or N(CH3)2. 27. The compound of Claim 16 which is N-L(4,6- dimethylpyrimidin-2-yl)aminocarbonyl]-2,3-dihydro-2methyl-7-benzothiophenesulfonamide, l,l-dioxide. 28. The compound of Claim 16 which is N-[(4 methaxy-6-methylpyrimidin-2-yl)aminocarb 3dihydro-2-methyl-7-benzothiophenesulfonamide, 1,1dioxide. 29. The compound of Claim 16 which is N-[(4,6 dimethoxypyrimidin-2-yl)aminocarbonyl]-2,3-dihydro-2 methyl-7-benzothiophenesulfonamide, l,l-dioxide. 30. The compound of Claim 15 which is N-[(4,6dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]-2,3-dihydro2-methyl-7-benzothiophenesulfonamide, l,l-dioxide. 31. The compound of Claim 16 which is N-[(4 methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]- 2, 3-dihydro-2-methyl-7-benzothiophenesulfonamide, l,l-dioxide. 32. The compound of Claim 16 which is N-[(4,6dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-2,3-dihydro-2-methyl-7-benzothiophenesulfonamide, 1,1dioxide. 33. The compound of Claim 16 which is 2,3-dihydro-N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-methylbenzofuran-7-sulfonamide. 34. The compound of Claim 16 which is N-[(4,6dimethoxypyrimidin-2-yl)aminocarbonyl]-2,3-dihydro-2methylbenzofuran-7-sulfonamide. 35. The compound of Claim 16 which is N-[(4,6dimethoxypyrimidin-2-yl)aminocarbonyl]-2,3-dihydroben zoLb]thiophene-7-sulfonamide, l,l-dioxide. 36. The compound of Claim 16 which is 2,3-dihydro-N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]benzo[b]thiophene-7-sulfonamide, 1,1-dioxide. 37. A compound of Claim 16 wherein J' is J1' or J3; R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined id Claim 16; R4 is H, R10 is H, CH3, C1 or Br, W is 0, Q is O,S or SOR, A' is as defined in Claim 16 excepting Xa, X1, G and Z' are as defined in EMI222.1 Claim 16, Y' is CH3, OCH3, OC2H5, CH2OCH3, NH2, NHCH3 or N(CH3)2. 38. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of any of Claims 1 to 37 and at least one of the following: surfactant, solid or liquid diluent. 39. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a com pound of any of Claims 1 to 37. 40. A method for regulating the growth of plants which comprises applying to the locus of such plants an effective but substantially non-phytotoxic amount of a compound according to any of claims 1 to 39. 41. A method for synthesizing compounds of the EMI222.2 EMI222.3 wherein J, J', A, A', R and W are as defined in Claims 1 or 16, which comprises the steps of: (I) (a) contacting and reacting an appropriate sulfonamide compound of general formula HSO2NH2 or J'SO2NH2 (IV) (IV') with diphenylcarbonate in the presence of a strong base; (b) isolating the resulting sulfonylcarbamate of formula EMI222.4 or EMI222.5 and contacting and reacting said sulfonyl carbamate with an appropriate amine EMI223.1 to produce compounds of the desired formula or (II) (a) contacting and reacting said sulfonamide (IV) or (IV') with an appropriate methyl carbamate compound of formula EMI223.2 (IV) (IV') in the presence of trimethylaluminum; and (b) isolating the resulting product of the desired formula; or (III) (a) contacting and reacting an appropriate sulfonyl isocyanate compound of formula JSO > NCO or J'S02NCW (VI) (VI') with an appropriate amine of said formula (III) or (III') in an inert aprotic solvent; and (b) isolating the resulting product of the desired formula. 42. A compound of the formula: EMI223.3 where Q1 is is 0, 5 or S02; R2 is H or C1-C3 alkyl; R3 is H or CH3; and R4 is H or CH3.

Inventors: PASTERIS, ROBERT JAMES, RORER, MORRIS PADGETT
Applicants: E.I. DU PONT DE NEMOURS AND COMPANY
Application year: 1982
Main classification: C07D405
IPC codes: A01N47, C07D307, C07D239, C07D333, C07D335, C07D491, C07D409, C07D405, C07D521