BENZOPYRANO(2,3-D)-V-TRIAZOLE INTERMEDIATES

Abstract: Compounds of formula (I): wherein R₁ is hydrogen or C₁₋₆ alkyl, and each phenyl group is optionally substituted by one or two inert substituents selected from C₁₋₃ alkyl, C₁₋₃ alkoxy and halogen; are useful intermediates for the preparation of compounds for the treatment of diseases the symptoms of which are controlled by the mediators of the allergic response.

Description: NOVEL INTERMEDIATES This invention relates to novel intermediates, to a process for their preparation, and for their use in the preparation of compounds having pharmacological activity. Published European Patent Application No. 0,034,004 discloses that compounds of the formula (A), and phzrmaceutically acceptable salts thereof: EMI1.1 wherein X is phenyl, optionally substituted by one halogen, C1 4 alkyl or C14 alkoxy; or pyridyl; R1 is hydrogen or C16 alkyl; and n is 1 to 6; may be used in the prophylaxis or treatment of diseases the symptoms of which are controlled by the mediators of the allergic response, for example asthma, hay-fever, rhinitis and allergic eczema. This European Patent Application also discloses a process for the preparation of the compounds of formula (A) from compounds of formula (B): EMI2.1 wherein R1 is as defined in formula (A), and Q' is a N-protecting group, such as labile benzyl groups, for example C16 alkoxy substituted benzyl groups, particularly 4-methoxy benzyl. With Q' as 4-methoxy benzyl, as exemplified in the European Patent Application, the preparation of a compound of formula (B) yields a mixture of isomers, which mixture may be used in the form of this mixture, or may first be separated into the individual isomers. Intermediates for the compounds of formula (A) have now been discovered which may be prepared directly in the form of one isomer, with corresponding advantages in ease of purification and characterisation. Accordingly the present invention provides a compound of formula (I): EMI3.1 wherein R1 is as defined in formula (A), and each phenyl group is optionally substituted by one or two inert substituents selected from C13 alkyl, C13 alkoxy and halogen. In formula (I) any substituent present in a phenyl is most suitably para- or meta-. 1-3 alkyl substituents are suitably methyl; C13 alkoxy substituents are suitably methoxy; halogen substituents are suitably bromine or chlorine. In general, when substituents are present in phenyl groups, then not more than one substituent on each phenyl is present. Preferably the trityl group in formula (I) is not substituted. Suitable examples of R1 include hydrogen, methyl, ethyl, and n- and iso-propyl. When other than hydrogen, R1 is suitably in the 5-position. Preferably R1 is hydrogen or 5-methyl. Suitably the HO- shown in formula (I) substitutes the ring in the 6-position. Compounds of formula (I) may be prepared by reacting a compound of formula (II): EMI4.1 wherein 1 15 defined in formula (A); and A1 is hydrogen, or an oxygen protecting group, with a triphenylmethyl halide wherein the phenyls may be substituted by inert substituents as hereinbefore described. The reaction is suitably carried out in the presence of a moderate base in a polar solvent. Examples of suitable bases include alkali metal salts such as the carbonates, for instance potassium carbonate. Examples of suitable solvents include N,N-dimethylformamide. The reaction is usually carried out between 20 80 C and for times between 2 and 24 hours, the reaction being followed by tIc. If an oxygen protected derivative of the compound of formula (II) is used, then suitable examples of such protecing groups include sulphonyl groups such as mesyl and tosyl; and acyl groups, such as acetyl. These groups, when present, may be removed after the reaction in conventional manner, for example in alkaline conditions. Compounds of the formula (II) may be prepared by the de-alkylation of a compound of formula (III): EMI5.1 wherein R1 is as defined in formula (A) and A2 is C14 alkyl, and thereafter if required, O-protection. This de-alkylation may suitably be effected with a base such as sodium thioethoxide in a polar solvent such as dimethylformamide, at moderately elevated temperatures, following the procedure of Feutrill et al, Tet Letters, 1970, 1327. The optional O-protection can be carried out in any convenient manner. For example we have found that sulphonyl and acyl functions selectively react at the hydroxyl functions, and thus are very suitable for use. Compounds of formula (III), and their preparation, are disclosed in published European Patent Application No: 79301318.6, Publication No: 0 007 727. (Compounds of formula (II), and their preparation, are also disclosed in published European Patent Application No. 0,032,821. The compounds of formula (I) are useful as intermediates in the preparation of compounds of the formula (A). The synthetic sequence resulting in the compounds of formula (A) follows in outline that described in the published European Patent Application Ks. 0,032,821 referred to above, but has advantages thereover. Firstly, the compound of formula (I) is coupled to a compound of formula (IV): EMI6.1 wherein X and n are as in formula (A), to yield a compound of formula (V): EMI6.2 wherein, as before, the trityl phenyls may be substituted. These compounds of formula (V) also form an important part of this invention, as useful intermediates. This reaction is generally carried out in the presence of a compound of formula (VI): R302C-N=N-C02 R4 (VI) wherein R3 and R4 are independently C16 alkyl, aryl or aryl-C16 alkyl, generally both ethyl, and a compound of formula (VII): PR5R6R7 (VII) wherein R5, R6 and R7 are independently C16 alkyl, C1-6 alkoxy, aryl, aryloxy, aryl-Cl 6 alkyl or aryl C16 alkoxy, generally all phenyl. The reaction is generally carried out at a nonextreme temperature, such as -20 to 100 C, in an inert aprotic organic solvent such as tetrahydrofuran, dioxan, ethyl acetate or benzene. The preparation of a compound of formula (V) may also be effected in an alternative manner by reacting together a compound of formula (VIII): EMI7.1 wherein R1 and n are as defined in formula (A) and each phenyl group is optionally substituted as defined in formula (I) and z is a group readily replaceable by a nucleophile (such as halogen, mesyl, tosyl, and a compound of formula (IX) EMI8.1 The reaction is generally carried out in the presence of a moderate base in a polar solvent. Examples of suitable bases include basic alkali metal salts such as the carbonates, for instancepooassiiin car s ate. E=ples of suitable solvents include ketones; such as methyl ethyl ketone, or polar solvents such as DMF. The reaction is conveniently carried out under reflux at temperatures of 50 to 110 C depending on the solvent, base and particular starting materials employed. The reaction time will depend on these parameters and on the temperature employed and this may readily be determined by routine trial and error. The reaction may be monitored by conventional methods such as thin layer chromatography. By way of example a reaction time of up to 24 hours is often suitable. Compounds of formula (VIII) can readily be prepared from compounds of formula (I) by reaction with Z-(CH2)n-B wherein B is halogen. Compounds of formula (IV) and (IX) are either known compounds, or may be prepared in analogous manner to known compounds. Secondly, compounds of formula (V) are deprotected to yield the desired end products of formula (A). This de-protection may be achieved extremely readily, another important advantage of this invention, with acid, for example with trifluoroacetic acid. The de-protection can also be achieved using hydrochloric acid in acetic acid at slightly raised temperatures (eg 550C). Compounds of formulae (V) and(VIII) are useful intermediates, and as such form an important part of this invention. Suitable and preferred examples of the compounds of formula (A) (and of the variables therein) for preparation in the manner of this invention are as described in published European Patent Application No: 0,034,004. Thus for the sake of completeness, in conpounds of formula (A); When X is an optionally substituted phenyl group, then it may be represented: EMI9.1 wherein R is hydrogen, halogen, C14 alkyl or C14 alkoxy. Suitable examples of R include hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy and ethoxy. More suitably R is hydrogen or halogen, preferably chlorine. Preferably R when halogen is in the o- or .2-position and most preferably is E-chloro. Alternatively X may be pyridyl. In such cases X is suitably 2- or 4-pyridyl, preferably 2-pyridyl, Suitable examples of R1 include hydrogen, methyl, ethyl and n- and iso-propyl. When other than hydrogen, R1 is suitably in the 5-position (that is, substituting the carbon atom adjacent the oxygen atom joined bridgehead carbon atom). Preferably R1 is hydrogen or 5methyl. n is suitably 2, 3 or 4, preferably 3. The side chain oxygen atom may join the benzo pyranot2,3-d]-v-triazole nucleus at any non-bridgehead carbon in the benzo moiety. Suitably however it will be joined at the 6-position (that is, substituting the carbon atom meta- to the oxygen atom joined bridgehead carbon atom). Within formula (A) there is a group of compounds of formula (A)': EMI10.1 wherein R is hydrogen, halogen, C 1-4 alkyl or C1-4 alkoxy; R1 is hydrogen or C16 alkyl; and n is 1 to 6. Suitable and preferred examples of the variable groups therein are as described in relation to formula (A). Within formula (A) there is also a group of compounds of formula (A)": EMI11.1 wherein R1 is hydrogen or C16 alkyl; and n is 1 to 6. Suitable and preferred examples of the variable groups therein are as described in relation to formula (A). From the aforesaid it will be appreciated, that one preferred sub-group of compounds of the formula (A) is of formula (A)"': EMI12.1 wherein R' is hydrogen or halogen, R1 is hydrogen or C16 alkyl, and m is 2, 3 or 4. Suitable and preferred values for Rt, R1 and m are as hereinbefore described for R, R1 and n respectively. Thus R' when halogen is preferably in theo- or p position, nost preferably -chloro. Similarly R1 when alkyl is preferably in the 5position, preferably hydrogen or 5-methyl. The triazole moiety of the compounds of formula (A) has an acidic hydrogen, and accordingly may form salts. Examples of pharmaceutically acceptable salts falling within the scope of this invention include the aluminium, alkali metal and alkaline earth metal salts such as the sodium, potassium and magnesium salts; and salts with ammonia, organic bases and amino compounds. The compounds of the formula g) may also form salts of the amino moieties, such as salts with hydrochloric and sulphuric acid. Particularly preferred compounds of formula (A) for preparation according to this invention are: 8-{3-[4-(4-chlorobenzyl)-1-piperazinyl)propyloxy}-9-oxo- lH, 9H-benzopyrano [ 2, 3-d -v-triazole; 6-{3-[4-(4-chlorobenzyl)-1-piperazinyl)propyloxy}-9-oxo- 5-n-propyl-lH,9H-benzopyranol2,3-d]-v-triazole; 6-{3-[4-(4-chlorobenzyl)-1-piperazinylZpropyloxy}-5- methyl-9-oxo-1H,9H-benzopyrano[2,3-d]-v-triazole; and 6-{3-[4-(4-chlorobenzyl)-1-piperazinyl]propyloxy}-9- oxo-lH,9H-benzopyrano[2,3-d]-v-triazole, and pharmaceutically acceptable salts thereof. The following Examples illustrate the invention. Example 1 (a) Ethyl l-benzyl-5- (3-methoxy-2-methylphenoxy) -v- triazole-4-carboxylate To a stirred solution of 3-methoxy-2-methylphenol (13.8 g, 0.1 mol) in dry DMF (100 mL) was added a 50% dispersion of NaH in mineral oil (4.8 g, 0.1 mol) and the solution was stirred for 1 hour at room temperature to ensure formation of the sodium salt. To this solution was added ethyl l-benzyl-5-chloro-v-triazole-4-carboxylate (26.6 g, 0.1 mol) in a single portion and the mixture stirred at 70-800C for 24 hours. After cooling, the solvent was removed in vacuo and the residue partitioned between EtOAc and water. The organic phase was washed with dilute aqueous Na0H, brine, and dried (MgS04). Evaporation of the solvent gave an oil which was chromatographed on SiO2 eluting with chloroform to give 30.8 g (84%) of the title compound as an oil which was not further purified, ';max (film) 1722 cm (C=O); 1H nmr (CDC13) 6 1.03 (3H, t, J=7Hz, ester CH3), 2.18 (3H, S, aromatic CH3), 3.85 (3H, s, OCH3), 4.11 (2H, g, J=7Hz, ester CH2), 5.37 (2H, S, benzyl CH2), 5.89 (1H, d, J=8.5Hz, C-4H), 6.59 (1H, d, J=8.5Hz, C-6H), 6.88 (1H, t, J=8.5Hz, C-5H), 7.29 (5H, S, Ph). (b) Ethyl 5-(3-methoxy-2-methylphenoxy)-1H-v-triazole- 4-carboxylate A solution of the above ester (30 g, 0.082 mol) in EtOH (400 mL) was hydrogenated at 96 C and 1,000 psi over 10% palladinised charcoal (0.3 g) until the reaction was complete (2-3 hours). The catalyst was removed from the cooled solution by filtration and the filtrate evaporated to an oil which crystallised after chromatography on SiO2 eluting with chloroform. Recrystallisation from toluenepetroleum ether [b.p. 60-800C) gave 20.6 g (91%) of the title ester of m.p. 107-108 C, may (mull) 3150 (broad, N-H), 1705 cm-1 (C=O); 1H nmr (CDCl3) # 1.26 (3H, t, J=7Hz, ester CH3), 2.12 (3H, s, aromatic CH3), 3.81 (3H, s, OCH3), 4.32 (2H, q, J=7Hz, ester CH2), 6.63 (2H, distorted d, C-4 and 6H), 7.09 (1H, m, C-5H), 10.3 (1H, broad, exchangeable, N-H). (Found: C, 56.28; H, 5.13; N, 5.18; C13H15N304 requires C, 56.31; H, 5.45; N, 5.16%). (c) 5-(3-Methoxy-2-methylphenoxy)-1H-v-triazole-4- carboxylic acid Hydrolysis of the above ester (19.4 g, 0.07 mol) with l.25M aqueous NaOH (220 mL) at 70-80 C for three hours gave on cooling and acidification 12.9 g (748) of the title acid. Recrystallisation from EtOAc-petroleum ether [b.p. 60-800C] gave material of m.p. 1290C (dec) after initial loss of water of crystallisation at ca 900, vmax (mull) 1685 cm 1 (C=O); 1H nmr (Me2SO-d6) # 2.10 (3H, s, aromatic CH3), 3.82 (3H, s, OCH3), 6.52 (1H, d, J=8.5Hz), 6.76 (1H, d, J=8.5Hz), 7.12 (1H, t, J=8.5Hz, C-5H). Found: C, 50.64; H, 4.65; N, 15.59; C11H11N3O4.O.75H2O requires C, 50.28; H, 4.80; N, 15.99%. (d) 6-Methoxy-5-methyl-9-oxo-1H,9H-benzopyranol[2,3-d]-v- triazole (Method A) Phosphoric oxide (240 g) was added to vigorously stirred 98% methanesulphonic acid (600 mL) at 800C (oil bath temperature) and the mixture stirred until homogenous (1 hour). Powdered 5- (3-methoxy-2-methylphenoxy) -lH-v- triazole-4-carboxylic acid (32.30 g, 0.13 mol) was added and the mixture stirred for 90 minutes at 800C when the mixture was cooled and poured into cold water. After 16 hours the precipitated product was filtered off, washed well with water and recrystallised from EtOH to give the title triazole (19.80 g, 66%) of mp 268-2700C (dec), may (mull) 3300 (broad, N-H), 1638 cm 1 (C=O); 1H nmr (Me2SO-d6) 6 2.26 (3H, s, aromatic CH3), 3.97 (3H, s, OCH3), 7.12 (1H, d, J=9Hz, C-7H), 8.02 (1H, d, J=9Hz, C-8H), 16.5 (1H, broad1 exchangeable N-H). Found: C, 57.30; H, 3.99; N, 18.47; C11H9N302 requires C, 57.14; H, 3.92; N, 18.18%. Evaporation of the ethanolic mother liquors afforded 3.4 g of solid shown by TLC (CHCl31 10% MeOH) to be a mixture of product and a faster (Rf ca 0.8) material. Chromatography on SiO2 eluting with chloroform gave 1.32 g of a white crystalline solid of mp 2030C (from EtOH) shown to be 3-diazo-7-methoxy-8-methylcounarin-4-oxide: #max (mull) 2180 (N2+) 1720 cm-1 (C=O); 1H nmr (CDCl3)# 2.28 (3H, s, aromatic CH3), 3.98 (3H, s, OCH3), 6.83 (1H, d, J=9Hz, C-6H), 7.90 (1H, d, J=9Hz, C-5H). Found: C, 57.23; H, 3.33; N, 12.27; C11H8N204 requires: C, 56.90; H, 3.47; N, 12.07%. Further elution with 30% MeOH in chloroform resulted in an additional 1.92 g (6%) of title compound. (Method B) Powdered 5- (3-methoxy-2-methylphenoxy) -lH-v-triazole- 4-carboxylic acid (0.55 g) was added to 85% polyphosphoric acid (5.5 g) and the mixture was vigorously stirred at 1000C for 3.75 hours when hplc monitoring indicated complete reaction. The cooled mixture was diluted with ice-water and allowed to stand overnight Filtration of the precipitated solid afforded 0.36 g (73%) of material identical with that prepared above and pure by tlc and nmr. (e) 6-hydroxy-5-methyl-9-oxo-lH,9H-benzopyrano [2,3-d]-v-triazole To a solution of ethanethiol (2.55 g, 3.01 ml, 0.04 mole) in dry N,N-dimethylformamide (50 ml) was added a 50% dispersion of sodium hydride in mineral oil (1.92 g, 0.04 mole) and the mixture was stirred for 15 minutes to complete the formation of the sodium salt. Finely powdered 6-methoxy-5-methyl-9-oxo-lH, 9H-benzopyrano[2,3-d]-v-triazole (1.27 g, 5.5 mmole) was then added and the temperature brought to 115 0C (oil bath temperature) for 90 minutes. After cooling the mixture was poured into water, extracted once with ether and then acidified with dilute hydrochloric acid. Crystals slowly separated on cooling which were filtered off, washed with water and dried. Recrystallisation from ethyl acetate-ethanol (with charcoal treatment) gave 1.188 g (99%) of title compound of mp 292-293 C (dec), vmax (mull) 3170, 2600 (broad), 1645, 1610, 1560, 1545 cm , 6 (DMSO - d6) 2.29 (3H, s); 6.97 (lah, d, J 9Hz); 7.90 (1H, d, J 9Hz); 11.00 (1H, exchangeable). (Found: C, 55.31; H, 3.03; N, 18.78 C0H7N3O3 requires: C, 55.30; H, 3.25; N, 19.35%). M (C10117N303) 217.0489. (f) 6-Hydroxy-5-methyl-9-oxo-2-triphenylmethyl- 9H-benzopyranof2,3-d]-v-triazole EMI20.1 A mixture of 6-hydroxy-5-methyl-9-oxo-lH,9H benzopyrano[2,3-dJ-v-triazole (0.868 g, 4 mmole), anhydrous potassium carbonate (0.276 g, 2 mmole) and dry N,N-dimethylformamide (25 ml) was stirred at 60 C for 10 minutes and triphenylmethyl chloride (1.114 g, 4 mmole) was added. After a further 24 hours at this temperature the solvent was removed in vacuo and water was added. The insoluble buff solid was filtered off, washed with water and dried in vacuo over P205. Chromatography on silica gel eluting with chloroform then gave 1.09 g (59%) of material of mp (methanol-chloroform) 282 0C (dec), #max(mull) 3260, 1650, 1598, 1590, 1545 cm-1; # (DMso-d6) 2.25 (3H, s); 6.97 (1H, d, J 9Hz); 7.22 (15H, m); 7.90 (1H, d, J 9Hz); 11.00 (1H, sharp exchangeable s). (Found: C, 76.19; H, 4.41; N, 8.89; C29H21N303 requires: C, 75.80; H, 4.61; N, 9.158). (g) 6-{3-[4- (4-Chlorobenzyl) -l-piperazinyl)-propyloxy) -5-methyl-9-oxo-2-triphenylmethyl-9H-benzopyrano [2,3-d]-v-triazole EMI21.1 A mixture of 6-hydroxy-5-methyl-9-oxo-2-triphenyl- methyl-9H-benzopyrano[2,3-d]-v-triazole (230 mg, 0.5 mmole), 1- (4-chlorobenzyl) -4- (3-hydroxypropyl)piperazine (135 mg, 0.5 mmole) and triphenyl phosphine (200 mg) in dry tetrahydrofuran (20 ml) was stirred at room temperature and a solution of diethyl azodiicarboxylate (180 mg) in dry tetrahydrofuran (2 ml) added over two minutes. After 1 hour at room temperature a further addition of triphenyl phosphine (200 mg) and diethyl azodiicarboxylate(180 mg) was made and the solvent evaporated after an additional hour. The residual gum was chromatographed on silica e;uting with chloroform to afford 120 mg (34%) of title compound of Rf 0.2 as a foam, 6 (CDC13) 2.05 (2H, quintet, J 6.2Hz), 2.33 (3H, s), 2.50 (8H, broad singlet), 2.58 (2H, t, J 6.2Hz), 3.49 (2H, s), 4.18 (2H, t, J 6.2Hz), 6.69 (1H, d, J 9.5Hz), 7.26 (19H, complex m), 8.22 (1H, d, J 9.5Hz). (h) 6-f 3-(4- (4-chlorobenzyl) -l-piperazinyl)propyloxy} 5-methyl-9-oxo-1H,9H-benzopyrano[2,3-d]-v- tri azole EMI22.1 Concentrated hydrochloric acid (1 ml) was added to a stirred solution of 6-(3-I4-(4-chlorobenzyl)- l-piperazinyll-propyloxy}-5-methyl-9-oxo-2-triphenylmethyl-9H-benzopyrano[2,3-d]-v-triazole (100 mg) in glacial acetic acid (5 ml) and the solution stirred at 500C for 1 hour. During this time some of the title compound separated as its dihydrochloride which was filtered off after cooling. Evaporation of the solvent Xnd trituration with methanol gave a further crop of material so that the isolated yield was 57 mg (75%) of compound of mp 252-254 C (dec), vmax (KBr) 3100-2300 (broad), 1673, 1610, 1554, 1455, 1417, 1280, 1102 cm . (Found: C, 53.07; H, 5.17; N, 12.76; C24H28N5C1303 requires: C, 53.29; H, 5.22; N, 13.08%.) Further product was evident in the methanolic mother liquors (by hplc analysis) but was not isolated. The material was coincident with authentic material on hplc and could be converted to the known free compound by basification to pH6. Example 2 (a) Ethyl 1-benzyl-5-(3-methoxyphenoxy)-v-triazole-4- carboxylate A 50% dispersion of sodium hydride in mineral oil (6.40 g, 0.13 mole) was added to a stirred solution of 3-methoxyphenol (16.40 g, 0.13 mole), in dry DMF (500 ml) and to the resulting sodium salt was added ethyl l-benzyl5-chloro-v-triazole-4-carboxylate (35.0 g, 0.13 mole). The reaction mixture was heated with stirring at 70 C for 21 hours and cooled. Removal of the DMF in vacuo gave a brown oil which was taken up in ether, washed with 1M sodium hydroxide solution, water and brine and dried (MgS04). Evaporation gave a red oil which crystallised on trituration with ether/petrol ether [40-60 C](1:1). Recrystallisation from ether/petrol ether 060-80 C) gave 33.75 g (53%) of product of mp 52-530C. (Found: C, 64.51; H, 5.27; N, 12.05; ClgHlgN304 requires: C, 64.58; H, 5.42; N, 11.89%). (b) Ethyl 5-(3-methoxyphenoxy)-1H-v-triazole-4- carboxylate Hydrogenolysis of a solution of ethyl l-benzyl-5-(3 methoxyphenoxy) -v-triazole-4-carboxylate (17.27 g) in ethanol (300 ml), over 10% palladium on charcoal at 100 C and 1000 psi resulted in clean removal of the Nbenzyl group in 2.5 hours. On cooling and removal of the catalyst by filtration, evaporation of the solvent gave an orange oil which crystallised on trituration. Recrystallisation from ethanol/water gave 9.16 g (71%) of product of mp 104-50C (Found: C, 54.92; H, 4.88; N, 15.71; C12H13N304 requires C, 54.75; H, 4.98; N, 15.96%). (c) 5- (3-Methoxvphenoxy) -lH-v-triazole-4-carboxylic acid Hydrolysis of ethyl 5- (3-methoxyphenoxy) -lH-v- triazole-4-carboxylate (9.10 g) r with 5% aqueous sodium hydroxide (110 ml), at 800C for 1 hour afforded the acid .c; was isolated after acidification of the cooled (o C) solution. Recrystallisation from ethyl acetate/ petrol ether [40-60 C]gave 6.20 g (76%) of material of rnp 133-40C (dec). (Found: C, 51.31; H, 3.60; N, 17.88. C10H9N304 requires: C, 51.07; H, 3.86; N, 17.86%). (d) 6-Methoxy-9-oxo-lH,9H-benzopyranol2,3-d]-V-triazole and 8-Methoxy-9-oxo-1H,9H-benzopyrano([2,3-d]-v-triazole EMI25.1 To a solution of phosphoruspentoxide (40 g) in 98% methane sulphonic acid (100 g) at 800C was added 5-(3 methoxyphenoxy)-lH-v-triazole-4-carboxylic acid (5.50 g) with vigorous stirring and the brown solution maintained at 80 C. After 4 hours hplc monitoring showed the absence of starting material. The solution was cooled, diluted with ice water and left to stand overnight. The pink precipitate was collected by filtration to yield 4.1 g, (75%) of the 6-methoxy and 8-methoxy mixed isomers in the ratio 2:1 respectively. The pure isomers could be separated by fractional crystallisation from ethanol. Data for pure 6-methoxy isomer mp 270-1 C (dec), ';max (mull) 1585, 1615, 1640, 1655 cm 6 DMSOd6; 3.94 (3H, s), 7.09 (1H, dd, J 2 & 7Hz), 7.27 (1H, d, J 2Hz), 8.12 (1H, d, J 7Hz). (Found: C, 54.97; H, 3.54; N, 19.51; C10H7N303 requires: C, 55.30; H, 3.25; N,19.35%). M = 217.0494 (CloH7N303) Data for pure 8-methoxy isomer mp 258-60 C, may (mull) 1550, 1610, 1658, 1670, 3130 cm 1; max 6 DMSOd6; 3.92 (3H, s), 7.06 (1H, dd, J 8Hz), 7.24 (1H, dd, J 8Hz), 7.77 (1H, t, J 8Hz). (Found: C, 55.31; H, 3.29; N, 19.64; C10H7N3O3 requires C, 55.30; H, 3.25; N, 19.35%). M+=217.0487 (C10H7N303). (e) 6-Hydroxy-9-oxo-1H,9H-benzopyrano[2,3-d]-v-triazole A 50% dispersion of sodium hydride in mineral oil (4.30 gr 0.09 mole) was added to a stirred solution of ethanethiol (5.46 g, 0.09 mole) in dry DMF (90 ml) and to the resulting sodium salt was added 6-methoxy-9-oxo lH,9H-benzopyrano[2,3-d]-v-triazole (2.25 g, 0.01 mole). The mixture was heated with stirring to 120 C for 1.5 h when TLC showed no starting material. The reaction was cooled and poured into ice-water. The product was isolated by acidification of the solution, filtration and recrystallisation from aqueous DMF to give 1.80 g (85%) of material of mp 3000C (dec); may (mull) 1550, -1 max 1580, 1650, 3215 cm ; 6 (DMSO-d6) 6.94 (2H, m), 8.08 (lH, d, J 9Hz), 11.01 (1H, s, exchanges with D20). M+=2O3.0337 (C9H5N303). (f) 6-Hydroxy-9-oxo-2-triphenylmethyl-9H-benzopyrano [2,3-d]-v-triazole Anhydrous potassium carbonate (0.89 g) was added to a solution of 6-hydroxy-9-oxo-1H,9H-benzopyrano[2,3-d]-v- triazole (0.865 g) in dry DMF (40 ml) and the mixture stirred for 15 minutes at room temperature. Triphenylmethylchloride (1.23 g) was added and stirring was continued for 2 days after which time the solvent was removed in vacuo and water added. After acidification to pH 4, the product was extracted into ethyl acetate and the dried (MgS04) extracts were evaporated to an oil. Chromatography on silica eluting with chloroform gave 0.755 g (40%) of title compound of mp 259-2600C (dec), '?max (mull) 3400-2600, 1665, 1615, 1550 cm 1; 6 (DMSO-d6) 7.07 (17H, m), 8.02 (1H, d, J 9Hz), 11.06 (1H, broad exchangeable, singlet). Found: C, 75.36; H, 4.64; N, 9.28; C28zlgN303 requires: C, 75.49; H, 4.30; N, 9.43%. Increased yields (up to 62%) can be obtained by further addition of triphenylmethylchloride (0.5 equivalent) after 24 hours. (g) 6-{3-[4-(4-Chlorobenzyl)-l-piperazinyll-propyloxy}- 9-oxo-2-triphenylmethyl-9H-benzopyrano[2,3-d)-v- triazole EMI28.1 To a stirred solution of 6-hydroxy-9-oxo-2-triphenyl methyl-9H-benzopyrano[2,3-dl-v-triazole (11.0 g, 0.025 mole), triphenylphosphine (11.80 g) and l-(4-chlorobenzyl)4-(3-hydroxypropyl)piperazine (6.68 g, 0,025 mole) in dry THF (250 ml) was added diethyl azodicarboxylate (7.84 g, 0.045 mole) dropwise. After 1 hour at ambient temperature the solvent was evaporated in vacuo and the residue chromatographed on silica (dichloromethane a chloroform) to give 6.40 g (37%) of title compound of mp (EtOH-CHC13) 182 C: #max (mull), 1550, 1620, 1670 cam ; 6 (DMSO-d6) 2.03 (2H, m), 2.48 (lOH, m), 3.47 (2H, s), 4.13 (2H, t, J 6Hz), 6.90 (1H, broad s), 7.01 (1H, dd), 7.26 (19H, m), 8.28 (1H, d, J 9Hz). Found: C, 71.87; H, 5.53; N, 9.85; C42H38C1N503.0.5H20 requires C, 71.52; H, 5.57; N, 9.93%. (h) 6-{3-[4-(4-Chlorobenzyl)-1-piperazinyl]-propyloxy}- 9-oxo-lH, 9H-benzopyrano [2 , 3-d] -v-triazole EMI29.1 Concentrated hydrochloric acid (5 ml) was added to a stirred solution of 6-{3-[4- (4-chlorobenzyl) -1-piperazin- yl) -propyloxy ) -9-oxo-2-triphenylmethyl-9H-benzopyrano [2,3-d]-v-triazole (6.20 g) in glacial acetic acid (200 ml) and the solution was stirred for 3 hours at 700C. The solution was evaporated in vacuo and the residue suspended in water and neutralised to pH 6.5 with dilute sodium hydroxide. The white solid was filtered off and boiled with ethanol to remove trityl alcohol. Filtration gave 3.81 g (94%) of material of mp (EtOH) 2100C (dec). Example 3 (a) 8-Hydroxy-9-oxo-lH, 9H-benzopyrano 2, 3-dI -v- triazole A 50% dispersion of sodium hydride in mineral oil (3.84 g, 0.08 mole) was added to a solution of ethanethiol (5.10 g, 6.02 ml, 0.08 mole) in dry N,Ndimethylformamide (100 ml) under a nitrogen atmosphere and the mixture was stirred at ambient temperature for 15 minutes to complete the formation of the sodium salt. Finely powdered 8-methoxy-9-oxo-lH,9H-benzo- pyrano[2,3-dl-v-triazole (2.36 g, 0.011 mole) was then added and the orange solution was heated with stirring to 1150C (oil bath temperature) for 90 minutes. After cooling the mixture was poured into ice-water (400 ml) and the solution washed with ether. The filtered aqueous layer was acidified to pH2 with hydrochloric acid to afford the title compound as an orange-pink precipitate. Recrystallization from methanol gave 1.18 g (53%) of pale orange solid of mp 2S6-258 C dec, vmax (mull) 3160, 1638, 1618 cm d tDMSo - d6) 6.86 (1H, d, J 8Hz); 7.14 (lH, d, J 8Hz); 7.73 (1H, t, J 8Hz); 12.30 (1H, exchangeable singlet). (Found: C, 53.12; H, 2.60; N, 20.90; C9H5N303 requires: C, 53.21; H, 2.48; N, 20.69%) (b) 8-Hydroxy-9-oxo-2-triphenylmethyl-9H-benzo- pyrano[2,3-d]-v-triazole EMI31.1 Anhydrous potassium carbonate (1.21 g, 8.8 mmole) followed by triphenylmethyl chloride (1.41 g, 4.9 mole) was added to a solution of 8-hydroxy-9-oxo1H,9H-benzopyrano[2,3-d]-v-triazole (0.96 g, 4.4 mmole) in dry N,N-dimethylformamLde (40 ml) and the mixture was stirred at room temperature for 24 hours. The solvent was then evaporated in vacuo and the yellow residue diluted with water. After bringing the pH to 3 with dilute hydrochloric acid the yellow precipitate was filtered off and dried in vacuo. Chromatography on silica eluting with chloroform and then 20% ethanol in chloroform gave 1.51 g (77%) of material of mp 166-167 C, #max (mull) 1650, 1625, 1543 cm , 6 (CDC13) 6.80 (lH, d, J 8Hz), 7.00 (1H, d, J 8Hz), 7.23 (15H, m), 7.55 (1H, t, J 8Hz), 12.36 (1H, exchangeable s). (Found: C, 75.26; H, 4.51; N, 9.24; C28H19N303 requires: C, 75.49; H, 4.30; N, 9.43%). (c) 8-{3-14-(4-chlorobenzyl)-1-piperazinyl]propyloxy} -9-oxo-2-triphenylmethyl-9H-benzopyrano[2,3-d] -v-triazole The title compound can be prepared from the product of step (b) in similar manner to the process described in Example l(g). (d) 8-{3-[4-(4-Chlorobenzyl)-1-piperazinyl]propyloxy} -9-oxo-1H,9H-benzopyrano[2,3-d]-v-triazole The title compound can be prepared from the product of step (c) in similar manner to the process described in Example 1(h). Example 4 a) 2-Allyl-3-methoxyphenol and 2-allyl-5-methoxy phenol A solution of allyl 3-methoxyphenyl ether (230 g, 1.40 mole; W N White and C D Slater, J Org Chem, 26, 3631-8 (1961)) in N,N-dimethylaniline (150 ml) was ref lured in an atmosphere of nitroqen for 4 hours. The orange solution was cooled, diluted with petroleum ether [bp 60-800C] and washed with 5M sulphuric acid. The organic phase was extracted with 2.5M sodium hydroxide, and the aqueous extracts re-acidified with 5M hydrochloric acid. The isomeric mixture of phenols was extracted with ethyl acetate, dried (MgS04) and evaporated in vacuo to yield 144g (63%) of brown oil the NMR of which showed 60% of 2-allyl-5-methoxy phenol, 40% of the other isomer. The two products could be separated by careful chromatography using silica gel, eluting with CH2C12/petroleum ether (bp 60-80 ) [1:1] to yield the faster running 2-allyl-3-methoxyphenol as a colourless oil, vmax film): 1598, 1610, 1637 (shoulder) 3475 cm 1. 6 CDC13: 3.40 (2H, m); 3.80 (3H, s); 5.10 (3H, m); 5.95 (1H, m); 6.47 (2H, d, J 9Hz); 7.30 (1H, t, J 9Hz), followed by the slower running 2-allyl-5-methoxyphenol as a pale bown oil, #max ( film): 1598, 1620, 1635 (weak) 3410 cm 6 CDC13: 3.31 (2H, m); 3.78 (3H, s); 5.23 (3H, m); 6.03 (1H, m); 6.40 (1H, bs); 6.47 (lH, dd, J 2Hz and 9Hz); 6.98 (1H, d, J 9 Hz). b) Ethyl 5-(2-allyl-3-methoxyphenoxy)-1-(4-methoxybenzyl) -v-triazole-4-carboxylate A 50% dispersion of sodium hydride in mineral oil (3.90 g, 0.08M ) was added to a stirred solution of 2-allyl-3-methoxyphenol (13.32 g, 0.08Mole) in dry 1 (300 ml) and to the resulting sodium salt was added ethyl -5-chloro-l- (4-methoxybenzyl) -v-triazole-4-carboxylate (24.0 g, 0.08 le), (D.R. Buckle and C.J.M.. Rockell, J. Chem. Soc. Perkin Trans. I, 1982, 627). The reaction fnixture was heated with stirring at C for 18 hours and thicooled. Removal of the DMF in vacuo gave a red oil which was taken up in ethyl acetate, washed with water, and dried (YgS04). Evaporation gave an oil which crystallised on trituration. Recrystallisation from ethanol/ petroleum ether [bp 60-80 C] gave 21.58 g (64%) of product, mp 109-100C. #max(mull): 1570, 1595, 1605, 1715 # CDCl3: 1.02 (3H, t, J 6Hz); 3. 3.48 (2H, m); 3.73 (3H, s); 3.83 (3H, s); 4.09 (2H, q, J 6Hz); 4.97 (2H, m); 5.28 (2H, s)t 5.87 (1H, d, J 9Hz); 5.90 (lH, m); 6.61 (1H, d, J 9Hz); 6.92 (1H, t, J 9Hz); 6.93 (4H, AB quartet Av=39 Hz, J 9Hz). Found: C, 64.87; H, 5.57; N, 9.86. C23H25N305 requires: C, 65.25; H, 5.95; N, 9.92%. M += 423.1822 (C23H25N305). c) Ethyl 5-(3-methoxy-2-n-propylphenoxy)-1H-v-triazole - 4 -carboxylate Hydrogenolysis of a solution of the above compound (1.0 g) in ethanol (300 ml) over 10% palladium on charcoal at 100 C and 1 000 psi resulted in reduction of the allyl double bond and clean removal of the N-(4methoxybenzyl)group within 10 hours. On cooling and removal of the catalyst by filtration, evaporation in vacuo gave an oil which was purified by column chromatography to yield 0.53 g (63%) of product, a white solid, mp 97-9 C. #max (mull): 1585, 1603, 1690, 3180 cm-1. # (CDl3): 0.87 (3H, t, J 7 Hz); 1.26 (3H, t, J 7Hz); 1.50 (2H, m); 2.63 (2H, t, J 7Hz); 3.82 (3H, s); 4.33 (2H, q, J 7Hz); 6.63 (2H, m); 7.06 (1H, t, J 8Hz). Found: C, 58.62; H, 6.42; N, 13.54; C15HlgN304 requires C, 59.00; H, 6.27; N, 13.76%. M = 305.1388 (C15HlgN304). d) 5-(3-Methoxy-2-n-propylphenoxy)-lH-v-triazole-4 -carboxylic acid Hydrolysis of ethyl 5-(3-methoxy-2-n-propylphenoxy)-lH-v-triazole-4-carboxylate (1.06 g) with 1.0 M sodium hydroxide solution (15 ml) at 70 C over 2 hours, afforded the acid which was isolated by acidification of the cooled solution. Recrystallisation from aqueous ethanol gave 0.84 g (88%) of product, mp 146-7 C (dec). #max(mull): 1595, 1608, 1695, 3200 cm-1, 6 DMSO-d6: 0.80 (3H, t, J 6Hz); 1.43 (2H, m); 2.52 (2H, m); 3.79 (lH, s); 6.48 (1H, d, J 8Hz); 6.73 (1H, d, J 8Hz); 7.08 (1H, t, J 8Hz). Found: C, 56.63; H, 5.47 ; N,14.81. C13H15N3O4 requires: C, 56.31; H, 5.45; N, 15.16%. M = 277.1052 (C13 H15N30 4). e) 6-Methoxy-9-oxo-5-n-propyl-1H,9H-benzopyrano[2,3-d] -v-triazole To a solution of phosphoric oxide (8.0 g) in 98Qo methanesulphonic acid (20 ml), at 800C was added 5-(3-methoxy-2-n-propylphenoxy)-1H-v-triazole-4- carboxylic acid (0.94 g, 3.4 mmole) with stirring and the pale red solution maintained at 800C for 3 hours, after which time HPLC showed a trace of starting material remaining. The reaction was cooled, diluted with water (100 ml), and the resultant brick red precipitate filtered off, washed with water and dried in vacuo. Recrystallisation from aqueous ethanol afforded 0.40 g (46%) of product as a cream solid, mp220-20C. (dec). vmaX (mull): 1610, 1660 cm 1. # DMSO-d6: 0.94 (3H, t, J 7 Hz); 1.60 (2H, m); 2.81 (2H, t, J 7Hz); 3.98 (3H, s); 7.21 (1H, d, J 9Hz); 8.08 (1H, d, J 9Hz). Found: C, 60.10; H, 5.03; N, 16.10. C13H13N303 requires: C, 60.22; H, 5.05; N, 16.21%. M = 259.0956 (C13H13N303). f) 6-Hydroxy-9-oxo-5-n-propyl-1H,9H-benzopyrano E2,3-dl-v-triazole EMI37.1 A 50% dispersion of sodium hydride in mineral oil (12.20 g, 0.25 M) was added to a stirred solution of ethanethiol (15.76g, 0,25 M) in dry DMF (250 ml) and to the resulting sodium salt was added 6-methoxy-9-oxo5-n-propyl-1H,9H-benzopyrano[2,3-d]v-triazole (9.40 g, 0.036 M). The mixture was heated with stirring to 120 C for 0.75 hours when HPLC showed no starting material. The reaction was cooled, evaporated in vacuo to dryness and the residue poured into water. The product was isolated by acidification of the solution. Recrystallisation from ethanol gave 5.84 g (66%) of pale yellow crystals, mp 283-4 C (dec). #max(mull): 1550, 1560, 1605, 1640, 3130 cm-1, 6 DMS0-d6: 1.00 (3H, t, J 7Hz); 1.64 (2H, m); 2.84 (2H, t, J 7Hz); 7.05 (lH, d, J 9Hz); 7.98 (lH, d, J 9Hz); 11,00 (lH, bs, exchanged D20); 16.45 (lH, bs, exchanged D20). Found: C, 58.55; H, 4.74; N, 17.03. (C12Hl;N303 requires: C, 58.77; H, 4.52; N, 17.1496) M = 245.0799 (C12H11N3O3). (g) 6-Hydroxy-9-oxo-5-n-propyl-2-triphenylmethyl-9H benzopyrano[2,3-d]-v-triazole EMI39.1 Triphenylmethylchloride (2.35 g, 8.2 mmole) was added to a stirred mixture of anhydrous potassium carbonate (1.67 g, 12 mmole) and 6-hydroxy-9-oxo-n-propyl-lH,9H- benzopyranot2,3-d]-v-triazole (2.0 g, 8.2 mmole) in dry DMF (50 ml) and the mixture stirred at room temperature for 24 hours. The solvent was evaporated to dryness in vacuo and the residue suspended in water. After acidification the product was extracted with chloroform. The evaporated, dried extracts were chromatographed on silica eluting with dichloromethane to give 1.36 g (34%) of title compound of mp(ethanol) 221-2220C (dec), vmax (mull) 1555, 1600, 1605, 1660, 3330 cm 1; 6 (DMSO-d6) 0.93 (3H, t, J 7Hz), 1.56 (2H, m), 2.78 (2H, t, J 7Hz), 7.01 (1H, d, J 9Hz), 7.28 (15H, m), 7.94 (1H, d, J 9Hz), 10.93 (1H, broad s, exchangeable). M+ 487.1889 (C31H25N303). (h) 6-{3-[4-(4-Chlorobenzyl)-1-piperazinyl]propyloxy}- 9-oxo-5-n-propyl-2-triphenylmethyl-9H-benzopyrano [2,3-d]-v-triazole The title compound can be prepared from the product of step (g) in a similar manner to the process described in Example 1(g). (i) 6-{3-14-(4-Chlorobenzyl)-1-piperazinyl}propyloxy}- 9-oXo-5-n-propyl-lH,9H-benzopyranol2,3-d]-v-triazole The title compound can be prepared from the product of step (h) in a similar manner to the process described in Example l(h). Example 5 a) Ethyl 5- (2-allyl-5-methoxyphenoxy) -l-benzyl-v- triazole-4-carboxylate To a solution of 2-allyl-5-methoxyphenol (15.41 g, 0.094 mmole) in dry DMF (150 ml) was added a 50% dispersion of sodium hydride in mineral oil (4.51 g, 0.094 mole) and the mixture stirred at ambient temperature for 15 minutes to complete formation of the sodium salt. Ethyl 1-benzyl-5-chloro-v-triazole-4-carboxylate (27.8 g, 0.094 mole) was added andthe reaction mixture stirred at 70-80 C for 16 hours. After cooling, the solvent was removed in vacuo and the product was partitioned between water and ethyl acetate. The organic phase was washed with dilute sodium hydroxide, water and brine and dried (MgS04). Evaporation and chromatography of the residual oil on silica with chloroform elution gave 32.54g(888) of the pure product. Recrystallisation from toluene-petroleum ether [bp 40-60 ] gave a white solid of mp 55-560C. #max(mull) 1738, 1620, 1555, 1505 cm-1. # (CDCl3): 1.08(3H, t, J 7.3 Hz); 3.41 (2H, d, J 5.4 Hz); 3.52 (3H, s); 4.18 (2H, q, J 7.3 Hz); 4.98 (1H, d); 5.15 (1H, d); 5.40 (1H, s); 5.78 (1H, d, J 2.7 Hz); 6.00 (1H, complex m); 6.60 (1H, d.d, J 8.4 Hz, 2.7 Hz); 7.14 (1H, d, J 8.4 Hz); 7.25 (5H, s). Found: C, 67.12; H, 6.00; N, 10.73. C22H23N304 requires: C, 67.16; H, 5.89; N, 10.68%. b) Ethyl 5- (5-methoxy-2-n-propylphenoxy) -lH-v- triazole-4-carboxylate Hydrogenolysis of a solution of ethyl 5-(2-allyl 5-methoxyphenoxy) -l-benzyl-v-triazole-4-carboxylate (30 g) in ethanol (300 ml) over 10% palladinized charcoal (1 g) at 1000C and 1 000 psi gave the title compound after 5 hours. Filtration and evaporation of the solution gave an oil which was purified on silica chromatography eluting with chloroform to give 22.73 g (98%) of product as a pale yellow oil. (film): 3200, 1720, 1620 cm 1. max 6 (CDCl3): 0.92 (3H, t, J 7Hz); 1.32 (3H, t, J 7,3 Hz); 1.60 (2H, sextet, J 8Hz); 2.60 (2H, t, J 8Hz); z.77 (3e, s); 4.41 (2H, q, J 7.3 Hz); 6.65 (1H, d, J 2.7 Hz); 6.70 (1H, d.d, J 8.4 Hz, 2.7 Hz); 7.15 (1H, d, J 8.4 Hz); 9.5 (1H, broad exchangeable). c) 5-(5-Methoxy-2-n-propylphenoxy)-1H-v-triazole- 4-carboxylic acid A solution of ethyl 5-(5-methoxy-2-n-propylphenoxy) -lH-v-triazole-4-carboxylate (22 g, 0.072 mole) in 1M aqueous sodium hydroxide (330 ml) was stirred at 700C for 2 hours, cooled and washed once with ethyl acetate. The aqueous phase was brought to pH 1 at O C and the precipitated oil extracted into ethyl acetate. The dried extracts were evaporated to give 19.79 g (98%) of crude material. Trituration with toluene-ether followed by petroleum ether fbp 40-6003 gave 12.56 g of compound of mp 112-30C (dec). Chromatography of the concentrated mother liquors on silica eluting with chloroform then 10% methanol in chloroform gave a further 2.76 g of material. Recrystallisation from ethyl acetate/petroleum ether gave mp 113-4 C. 9 ax (mull): 3170, 2650 (broad), 1720, 1620, 1530, 1505 cm 6 (DMSO-d6): 0.88 (3H, t, J 6Hz); 1.55 (2H, sextet, J 6Hz); 2.56 (2H, t, J 6Hz); 3.70 (3H, s); 6.57 (1H, d, J 2Hz); 6.73 (1H, d.d, J 2Hz, 8Hz); 7.22 (1H, d, J 8Hz); 14.3 (2H, broad exchangeable signal). Found: C, 55.97; H, 5.52; N, 14.92. C13H15N304 requires: C, 56.31; H, 5.45; N, 15.16%. d) 8-Methoxy-9-oxo-5-n-propyl-lH,9H-benzopyrano[2,3-d]- v-triazole To a solution of phosphoric oxide (8.0 g) in 98% methanesulphonic acid (20 ml) was added finely powdered 5- (5-methoxy-2-n-propylphenoxy) -lH-v-triazole-4- carboxylic acid (0.94 g, 3.4 mmole) and the mixture was stirred at 80 C for 1.5 hours when no acid remained. The red solution was cooled and diluted to 200 ml with water. The bulk of the acidic solution was neutralized and the precipitated solid filtered off and recrystallised from ethanol to give 0.62 g (70%) of title compound of mp 229-2310C (dec). may (mull): 3050 (broad), 1670, 1597, 1530 cm 6 (DMSO-d6): 0.96 (3H, t, J 7Hz); 1.66 (2H, sextet, J 7Hz); 2.77 (2H, t, J 7.5Hz); 3.92 (3H, s); 6.99 {1H, d, J 9Hz); 7.62 (1H, d, J 9Hz). Found: C, 60.18; H, 5.02; N, 16.13. C13H13N303 -requires: C, 60.22; H, 5.05; N, 16.218. e) 8-Hydroxy-9-oxo-5-n-propyl-lH,iH-benzopyrano [2, 3-d] -v-triazole To a solution of ethane thiol (10.2 g, 12.05 ml, 0.16 mole) in dry DMF (200 ml) was added a 50% dispersion of sodium hydride in mineral oil (7.65 g, 0.16 mole) and the mixture was stirred for 15 minutes at ambient temperature to complete formation of the sodium salt. Finely powdered 8-methoxy-9-oxo-5-n propyl-lH,9H-benzopyrano[2,3-d]-v-triazole (5.66 g, 0.022 mole) was added in one portion and the total was stirred at 1200C (oil bath temperature) for 1 hour. The DMF was removed in vacuo and water (250 ml) was added to the residue. After washing the resulting solution with ether the solution was cooled to 0 C and acidified. The precipitated oil crystallized on trituration to give a yellow solid of tlc purity which was filtered off, washed with water and dried to give 5.09 g (95%) of the title compound of mp 208-9 C (dec) (from ethyl acetate). vmax (mull): 313O (broad), 1650, 1638, 1618, 1560, 1525 cm-1. 6 (DMSO-d6): 0.95 (3H, t, J 7.2 Hz); 1.68 (2H, sextet, J 7Hz); 2.78 (3H, t, J 7Hz); 6.82 (1 H, d, J 8Hz); 7.62 (1H, d, J 8Hz); 12.24 (1H, sharp exchangeable s); 15. 2 (1H, broad exchangeable). (Found: C, 59.08; H, 4.41; N, 16.83. C12H11N303 requires: C, 58.77; H, 4.52; N, 17.14%) f) 8-Hydroxy- 9-oxo- 5-n-propyl-2- (triphenylmethyl) -9H- benzopyrano[2,3-d]-v-triazole EMI46.1 Anhydrous potassium carbonate (1.04 g) and triphenylmethyl chloride (1.39 g, 5 mmole) were added to a solution of 8-hydroxy-9-oxo-5-n-propyl-lH,9H benzopyrano(2,3-d]-v-triazole (1.23 g, 5 mmole) in dry DMF (50 ml) and the mixture was stirred at 60 C for 18 hours. After cooling the solvent was removed in vacuo and water added After bringing the pH to 6 with hydrochloric acid the yellow solid was filtered off and dried to give 2.26 g of crude title compound. Chromatography on silica eluting with dichloromethane gave 1.60 g (69%) of title compound as a yellow solid, mp (ethanol-chloroform) 194-5 0C. #max(mull): 1662, 1625, 1550 cm-1. 6 (CDC13): 0.98 (3H, t, J 7.2 Hz); 1.66 (2H, sextet, J 7.2 Hz); 2.77 (2H, t, J 7.2 Hz); 6.82 (1H, d, J 8Hz); 7.3 (15H, m); 7.48 (1H, d, J 8Hz); 12.33 (1H, sharp exchangeable s). (Found: C, 74.85; H, 5.46; N, 8.27. C31H25N3O3.O.5H2O requires: C, 74.98; H, 5.78; N, 8.46%) From the aqueous phase was obtained 0.36 g of starting phenol by acidification to pH 1. g) 8-63-14-(4-Chlorobenzyl)-l-piPerazinyl]propyloxy}-9- oxo-5-n-propyl-2-triphenylmethyl-9H-benzopyrano [2,3-d]- v-triazole The title compound can be prepared from the product of step (f) in a similar manner to the process described in Example l(g). h) 8-{3-[4-(4-Chlorobenzyl)-1-piperazinyl]propyloxy}-9- oxo-5-n-propyl-1H,9H-benzopyrano[2,3-d]-v-triazole The title compound can be prepared from the product of step (g) in a similar manner to the process described in Example l(h). Example 6 a) 6-(3-Chloropropyloxy) -2-triphenylmethyl-9-oxo-9H benzopyrano[2,3-d]-v-triazole A mixture of 6-hydroxy-2-triphenylmethyl-9-oxo-9H- benzopyrano[2,3-d]-v-triazole (1 g, 0.00224 mole), l-bromo- 3-chloropropane (0.355 g, 0.00224 mole) and anhydrous potassium carbonate (0.47 g, 0.00337 mole) in butanone (100 ml) was stirred under reflux for eighteen hours. The cooled mixture was filtered and the filtrate evaporated under vacuum to give a white oil. Trituration with 60-80 petroleum ether gave 1.1 g (94%) of product of m.p. 188193 C. u (KBr): 1680, 1620, 1548, 1490, 1445, 1265 cm ; max 6 (CDC13): 2.22 (2H, quintet, J=6 Hz, CH2CH2CH2); 3.70 (2H, t, J=6 Hz, CH2-C1)- 4.20 (2H, t, J=6 Hz, CH20), 6.90 (lH, d, J=2 Hz, C-5H), 6.92 (lH1 d.d, J=2 Hz, 8 Hz, C-7H), 7.21 (15H, m, trityl aromatics) 8.28 (1H, d, J 8 Hz, C-8H). b) 6-{3-[4-(4-Chlorobenzyl)-l-piperazinyl]propyloxy}-2- triphenylmethyl-9-oxo-9H-benzopyrano[2,3-d]-v- triazole A mixture of 6-(3-chloropropyloxy)-2-triphenylmethyl- 9-oxo-9H-benzopyranol[2,3-d]-v-triazole (1.04 g, 0.0019 mole) l-(4-chlorobenzyl)piperazine (0.42 g, 0.0019 mole) sodium iodide (0.30 g, 0.002 mole) and anhydrous potassium carbonate (0.55 g, 0.004 mole) in butanone (100 ml) was stirred under reflux for twenty-four hours. When cool the mixture was filtered and the filtrate evaporated under vacuum to give a fawn solid. Chromatography on silica gel eluting with chloroform to chloroform-methanol (9:1) gave 0.9 g (65%) of pure material identical with that prepared in Example 2(g).

Claims: CLAIMS 1. A compound of formula (I): EMI50.1 wherein R1 is hydrogen or C16 alkyl, and each phenyl group is optionally substituted by one or two groups selected from C13 alkyl, C13 alkoxy and halogen. 2. A compound according to claim 1, wherein any substituent on a phenyl group is in the meta- or para- position. 3. A compound according to claim 1, wherein each phenyl group is unsubstituted. 4. A compound according to any one of claims 1 to 3, wherein R1 is in the 5-position. 5. A compound according to any one of claims 1 to 4, wherein the OH group is in the 6-position. 6. A compound selected from 6-hydroxy-5-methyl-9-oxo-2 triphenylmethyl-9H-benzopyranot2,3-d]-v-triazole; 6-hydroxy- 9-oxo-2 -triphenylmethyl- 9H-benzopyrano f2,3-dS-v-triazole; 8-hydroxy-9-oxo-2-triphenylmethyl 9H-benzopyranoE2,3-d)-v-triazole; and 6-hydroxy-9 oxo-5-n-propyl-2-triphenylmethyl-9H-benzopyrano[2,3-d]- v-triazole. 7. A process for preparing a compound of formula (I) according to claim 1, in which a compound of formula (Il): EMI51.1 wherein A1 is hydrogen or an oxygen protecting group, is reacted with a triphenylmethyl halide wherein each phenyl group is optionally substituted as defined in claim 1. 8. A process for preparing a compound of formula (A): EMI51.2 wherein X is phenyl, optionally substituted by one halogen, C14 alkyl or C14 alkoxy; or pyridyl; R is halogen or C16 alkyl; and n is 1 to 6 which comprises deprotecting a compound of formula (V): EMI51.3 wherein each phenyl group is optionally substituted as defined in claim 1. 9. A compound of the formula (V): EMI52.1 wherein X, R1 and n are as defined in formula (A) and each phenyl group is optionally substituted as defined in formula (I). 10. A compound of the formula (VIII): EMI52.2 wherein R1 and n are as defined in formula (A), Z is a group readily replaceable by a nucleophile, and each phenyl group is optionally substituted as defined in formula (I).

Inventors: BUCKLE, DEREK RICHARD
Applicants: BEECHAM GROUP PLC
Application year: 1982
Main classification: C07D491
IPC codes: C07D491, C07C43, C07D249