HERBICIDAL TRIAZOLE UREAS

Abstract: Triazole and imidazole ureas of the formulae wherein R′ is H, CH₃ or C₂H₅; R₁ is H, Cl or various organic groups; R₁′ is CH₃, C₂H₅, SCH₃, OCH₃ or OC₂H₅; R₂ is alkyl, substituted alkyl, alkenyl or alkynyl; R₂ is CH₃, C₂H₅ or OCH₃; W is O or S, and Z and Z′ are phenyl, naphthyl, pyridyl or thienyl, any of which may be substituted, or Z may additionally be an optionally substituted benzyl, phenoxy or furyl groupe; exhibit pre-emergence and post-emergency herbicidal activity. The compounds may be formulated for agricultural use in conventional manner. The novel triazole derivatives may be made by reacting a compound of formula with an isocyanate or isothiocyanate of formula ZSO₂NCW The imidazole derivatives may be made analogously.

Description: 11+Ierbicidal triazole and imidazole ureas" Background of the Invention This invention relates to diazole and triazole ureas and in particular their use as agricultural chemicals and particularly as herbicides. U.S. Patent 4,127,405 teaches compounds which are useful for controlling weeds in wheat having the formula: EMI1.1 R3 and R6 are independently hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, nitro, trifluoromethyl, cyano, CH35(0)n- or CH3CH2S(O)n-; R4 is hydrogen, fluorine, chlorine, bromine or methyl; R5 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy; R7 is hydrogen, fluorine, chlorine, bromine, alkyl of 1-2 carbon atoms or alkoxy of 1-2 carbon atom; R8 is hydrogen, methyl, chlorine or bromine; Rg and R10 are independently hydrogen, methyl, chlorine or bromine; W and Q are independently oxygen or sulfur; n is 0, 1 or 2; ; X is hydrogen, chlorine, bromine, methyl, ethyl, alkoxy of 1-3 carbon atoms, tri fluoromethyl, CH3S- or CH30CH2-; and Y is methyl or methoxy; or their agriculturally suitable salts; provided that: (a) when R5 is other than hydrogen, at least one of R3, R4, R6 and R7 is other than hydrogen and at least two of R3, R4, R6 and R7 must be hydrogen; (b) when R5 is hydrogen and all of R3, R4, R6 and R7 are other than hydrogen, then all of R3, R4, R6 and R7 must be either chlorine or methyl; and (c) when R3 and R7 are both hydrogen, at least one of R4, R5 or R6 must be hydrogen. French Patent No. 1,468,747 discloses the following para-substituted phenylsulfonamides, useful as antidiabetic agents: EMI2.1 wherein R = H, halogen, CF3 or alkyl. Logemann et al., Chem. Ab., 53, 180529 (1959), disclose a number of sulfonamides, including uracil derivatives and those having the formula: EMI3.1 wherein R is butyl, phenyl or EMI3.2 and R1 is hydrogen or methyl. When tested for hypoglycemic effect in rats (oral doses of 25 mg/lOO g), the compounds in which R is butyl and phenyl were most potent. The others were of low potency or inactive. Wojciechowski, J. Acta. Polon. Pharm. 19, p. 121-5 (1962) (Chem. Ab., 59 1633 e) describes the synthesis of N-±(2,6-dimethoxypyrimidin-4-yl)aminocar- bonyl)-4-methylbenzenesulfonamide: EMI3.3 Based upon similarity to a known compound, the author predicted hypoglycemic activity for the foregoing compound. Netherlands Patent 121,788, published September 15, 1966, teaches the preparation of compounds of Formula (i), and their use as general or selective herbicides, EMI4.1 wherein R1 and R2 may independently be alkyl of 1-4 carbon atoms; and R3 and R4 may independently be hydrogen, chlorine or alkyl of 1-4 carbon atoms. Compounds of Formula (ii), and their use as antidiabetic agents, are reported in J. Drug. Res. 6, 123 (1974), EMI4.2 wherein R is pyridyl. The presence of undesired vegetation causes substantial damage to useful crops, especially agricultural products that satisfy man's basic food needs, such as soybeans, barley, wheat, and the like. The current population explosion and concomitant world food shortage demand improvements in the efficiency of producing these crops. Prevention or minimizing the loss of a portion of valuable crops by killing, or inhibiting the growth of undesired vegetation is one way of improving this efficiency. A wide variety of materials useful for killing, or inhibiting (controlling) the growth of undesired vegetation is available; such materials are commonly referred to as herbicides. The need exists, however, for still more effective herbicides that destroy or retard weeds without causing significant damage to useful crops. Summary of the Invention This invention relates to novel compounds of Formula I, suitable agricultural compositions containing them, and their method of use as pre-emergence and post-emergence herbicides. EMI5.1 wherein R1 is H, C1-C4 alkyl, C3-C4 alkenyl, C3 C4 alkynyl, SR4, OR5, CH20R6, CH2CH2OR6, N(CH3)2, CF3, CF2CF3, Cl, NHCH3, N(CH3)2, CH(OCH3)2 or EMI5.2 R2 is C1-C4 alkyl, C3C4 alkenyl, C3-C4 alkynyl, CH20CH3, CH2CH2OCH3, CH2SCH3, CH2CH2SCH3 or C1-C4 alkyl substituted with 1-3 F atoms; R3 is H or CH3; R4 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2C02Ró or CH(CH3)CO2R6; R5 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2CO2R6, CH(CH3)C02R6 or CH2CF3; R6 is C1-C4 alkyl; W is O or S; ; Z is EMI6.1 R7 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C(O)NR21R22, Cl, Br, NO2, CF3, C02Rg, SO2NR10R11, C(O)SR10, SO2N(OCH3)CH3, QSO2R12, S(O)nR13, CH2CO2R20, CH(CH3)CO2R20, CH2S(O)nR13, CH(CH3)S(O)nR13, C3-C4 alkenyloxy, C3-C4 alkynyloxy, C1-C2 alkyl substi tuted with either OCH3 or OC2H5, or C1-C3 alkoxy substituted with either a) 1-5 atoms of C1, Br or F or b) OCH3 or OC2H5; R8 is H, F, C1, Br, CF3, NO2, C1-C3 alkyl or C1-C3 alkoxy; R9 is C1-C6 alkyl, CH2CH2OCH3 CH2CH2OCH2CH3, CH2CH2CH2OCH2CH3, C3-C6 alkenyl, C3-C6 alkynyl or C1-C3 alkyl substituted with 1-3 atoms of C1 or F; R10 and Rll are independently C1-C3 alkyl; R12 is C1-C4 alkyl, CH2CH20CH3, CH2CH2CH2 CH3 or C1-C4 alkyl substituted with 1-3 atoms of F, Cl or Br; ; R13 is C1-C4 alkyl, allyl, C1-C3 alkyl substituted with 1-5 atoms of F, Cl or Br; n is 0, 1 or 2; Q is O or NCH3; R14 is H, CH3, OCH3, F, C1, Br, NO2, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12 or S(O)nR13; R15 is H, C1, Br, CH3, OCH3 or NO2; R16 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C1, Br, CF3, CO2R20, S02NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R17 is H, F, C1, Br, CH3 or OCH3; w' is O or S; R18 is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, NO2, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R19 is C1, NO2, CF3, C02R9, SO2N(OCH3)CH3, SO2NR10r11, QSO2R12, S(O)nR13 or C1-C2 alkoxy substituted with 1-5 atoms of Cl or F; R20 is c1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; R21 is C1-C3 alkyl or C6H5; R22 is C1-C3 alkyl; and R21 and R22 may be taken together to be EMI8.1 provided that (1) the total number of carbon atoms of R10 and R11 is less than or equal to 4; (2) the total number of carbon atoms of R and R2 is less than or equal to 6; (3) when W' is 0, then R18 is H, C1, Br, CH3 or C02R20; (4) when W' is 0 and R18 is H, C1, Br or CH3, then Z is EMI8.2 (5) when W is S, then R3 is H; (6) when R7 is H, then R8 is H; and (7) R14 and R15 may not both be N02. This invention also relates to novel compounds of Formula Ia, suitable agricultural compositions containing them, and their method of use as pre-emergence and post-emergence herbicides. EMI8.3 wherein R' is H, CH3 or C2H5; R11 is CH3, C2H5, SCH3, OCH3 or OC2Hg; R2' is CH3, C2H5 or OCH3; Z' is EMI9.1 FR7 is C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, NO2, CF3, CO2R9, SO2NR10R11, C(O)NR21R22, SO2N(OCH3)CH3, QSO2R12, S(O)nR13, C(O)SR10, CH2CO2R20, CH(CH3)CO2R20, CH2S(O)nR13, CH(CH3)S(O)nR13, C3C4 alkenyloxy, C3-C4 alkynyloxy, C1-C2 alkyl substi tuted with either OCH3 or OC2H5, or C1-C3 alkoxy substituted with either a) 1-5 atoms of C1, Br or F or b) OCH3 or C2H5; FR8 is H, F, Cl, Br, CF3, NO2, C1-C3 alkyl or C1-C3 alkoxy; R9 is C1-C6 alkyl, CH2CH20CH3, CH2CH2OCH2CH3, CH2CH2CH2CH2OCH2CH3, C3-C6 alkenyl, C3-C6 alkynyl or C1-C3 alkyl substituted with 1-3 atoms of Cl or F; R10 and R11 are independently C1-C3 alkyl; ; R12 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2CH2OCH3 or C1 C4 alkyl substituted with 1-3 atoms of F, Cl or Br; R13 is C1-C4 alkyl or allyl; R14 is H, CH3, OCH3, F, C1, Br, NO2, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12 or S(O)nR13; R16 is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, CF3, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br,No2, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R20 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2C1 or CH2CH=CH2; Q is O or NCH3; 21 is C1-C3 alkyl or C6H5; R22 is C1-C3 alkyl; and R21 and R22 may be taken together to be EMI10.1 provided that (1) the total number of carbon atoms of R10 and R11 is less than or equal to 4; and (2) R1' and R2' can not simultaneously be H; and their agriculturally suitable salts. Preferred for reasons of higher herbicidal activity or more favorable ease of synthesis are: (1) Compounds of Formula I wherein W is 0 and R3 is H. (2) Compounds of Preferred 1 where Z is EMI10.2 W' is S; R19 is CO2CH3, SO2N(CH3)2 or SO2CH3; and R15 and R17 are H. (3) Compounds of Preferred 2 where Z is EMI11.1 (4) Compounds of Preferred 3 where R1 is C1-C2 alkyl, SR4, OR3, CH2OCH3, N(CH3)2 or C1; R2 is C1-C2 alkyl, CH2CF3, CH2CH=CH2 or CH2C=CH; and R4 and R5 are independently CH3 or C2H5 (5) Compounds of Preferred 4 where Z is EMI11.2 R7 is other than H; and R8 is H, F, C1, Br, CF3, CH3 or OCH3. (6) Compounds of Preferred 5 where R7 is Cl, NO2, Co2R9, SO2NR10R11 or OSO2R12; R8 is H; Rg is C1-C3 alkyl, CH2CH=CH2, CH2CH2OCH3 or CH2CH2C1; R10 and R11 are independently c1-C2 alkyl; and R12 and R13 are independently C1-C3 alkyl. (7) Compounds of Preferred 6 where FR9, FR10, 11 R12 and R13 are CH3; (8) Compounds of Formula Ia where R' is CH3 or C2H5. (9) Compounds of Preferred 8 where Z' is EMI12.1 and R8 is H, F, C1, Br, CF3, CH3 or OCH3. (10) Compounds of Preferred 9 where R7 is Cl, NO2, CO2R9, So2NR10R11, OSO2R12 or SO2R13; R8 is H; Rg is C1-c3 alkyl, CH2CH2=CH2, CH2CH2OCH3 or CH2CH2Cl; R10 and R11 are independently C1-C2 alkyl; and R12 and R13 are independently C1-C3 alkyl. (11) Compounds of Preferred 10 where R9, R10, R11, R12 and R13 are CH3. Specifically preferred for reasons of their highest herbicidal activity and/or most favorable ease of synthesis are: 2-E[(5-methylthio-1-methyl-lH-1,2,4-triazol-3-yl)- aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester; 2-[[5-ethylthio-1-methyl-1H-1,2,4-triazol-3-yl) aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester; 2-EE(5-ethyl-l-methyl-lH-l,2,4-triazol-3-yl)amino- carbonyl)aminosulfonyl]benzoic acid, methyl ester; 2-[E(5-methoxy-1-methyl-lH-1,2,4-triazol-3-yl)aminc- carbonyl)aminosulfonyl]benzoic acid, methyl ester; N-E(5-methoxy-1-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl)-2-chlorobenzenesulfonamide; ; N-[(5-methoxy-1-methyl-1H-a,2,4-triazol-3-yl)amino carbonyl]-N',N'-dimethyl-1,2-benzenedisulfonamide; and 2-EC(4,5-dimethyl-lH-imidazol-2-yl)aminocarbonyl]amino- sulfonyl]benzoic acid, methyl ester. Synthesis Many of the compounds of Formula I can be prepared by reacting an appropriate 3-amino-l,2,4-tria- zole of Formula II with an appropriately substituted sulfonylisocyanate or isothiocyanate of Formula III, as shown in Equation 1. Equation 7 EMI14.1 wherein Z, R1, R2, R3 and W are as previously defined. The reaction of Equation 1 is best carried out in inert organic solvents such as methylene chloride, tetrahydrofuran, or acetonitrile at ambient pressure and temperature. The mode of addition is not critical; however, it is often convenient to add the sulfonylisocyanate or isothiocyanate to a stirred suspension or solution of the aminotriazole. Since such isocyanates and isothiocyanates usually are liquids, their additions can be easily controlled. The reaction is generally exothermic. In some cases, the desired product is insoluble in the warm reaction medium and crystallizes from it in pure form. Products soluble in the reaction medium are isolated by evaporation of the solvent, trituration of the solid residue with solvents such as l-chlorobutane or ethyl ether, and filtration. An alternate method for synthesizing compounds of Formula I in which W = 0 is illustrated in Equation 2. An appropriate sulfonylisocyanate of Formula III is allowed to react with an appropriate 3-amino-lH1,2,4-triazole of Formula IV to give an intermediate urea of Formula V which is then alkylated with a reagent of Formula R2X to yield compounds of Formula I: Equation 2 EMI15.1 wherein X is a good leaving group such as bromine, iodine, chlorine, alkylsulfonate, FR205d?, or e-toluenesulfonate, and Z, R1, FR2 and R3 are as previously defined. The conditions for reacting the 3-amino-lH-triazole of Formula IV and sulfonylisocyanate or sulfonylisothiocyanate in Equation 2 are similar to that described for the condensation involving triazole II in Equation 1, however it is desirable to have an equimolar amount of sulfonylisocyanate react with triazole IV. The alkylation reaction illustrated in Equation 2 between the sulfonylurea intermediate V and R2X (wherein X is a good leaving group such as bromine, iodine, chlorine, alkylsulfonate, R2OSO3, or p-toluenesulfonate) is preferably carried put is the presence of an alkaline material and preferably in the presence of a solvent. Suitable alkaline materials, include, for example, the alkali and alkaline earth metal carbonates, bicarbonates; acetates, and hydroxides such as potassium carbonate, sodium carbonate, potassium carbonate, potassium acetate, sodium and potassium hydroxide. Other organic bases such as pyridine and triethylamine may also be used. Suitable solvents include inert aprotic solvents such as acetone, methyl ethyl ketone, acetonitrile, methylene chloride, dimethylformamide, dimethylacetamide, and dimethylsulfoxide The alkylation reaction conditions of Equation 2 vary according to the nature of the reactants, the base and solvent present. Usually, the reaction is facilitated by the application of heat (between 450 and 1280) however, lower reaction temperatures may be desirable in some instances as will be readily apparent to one skilled in the art. Compounds of Formula Ia are prepared by the general procedure of Equation Ia. Z', R', R1' and R2, are as previously defined a.nd W is 0. Equation la EMI17.1 The reaction of Equation la is best carried out in an inert aprotic solvent, such as methylene chloride, tetrahydrofuran, or acetonitrile at ambient pressure and temperature. In some cases, the desired product may crystallize from the reaction medium and may be filtered. Reaction products which are soluble in the reaction medium may be isolated by evaporation of the solvent, trituration of the residue with solvents such as diethyl ether, l-chlorobutane, or hexane. Chromatography (e.g., silica gel) may also be necessary for purification. The intermediate aryl sulfonylisocyanates of Formula III (w=O) can be prepared by reacting the corresponding aryl sulfonamides with phosgene in the presence of n-butyl isocyanate at reflux in a solvent such as chlorobenzene or xylenes, according to the procedure of H. Ulrich and A. A. Y. Sayigh, Newer Methods of Preparative Organic Chemistry, Vol. VI, p. 223-241, Academic Press, New York and London, W. Forest Ed., or by the methods taught in U.S. Patent 4,127,405 (1978), U.S. 4,238,671 (1980) and EP-A-23,141. The intermediate pyridyl sulfonylisocyanates of Formula III (W=O) can be prepared by reacting an N-(alkylaminocarbonyl)pyridinesulfonamide with phosgene as described in EP-A- 13,480, to which the reader is referred for further information. The N-(alkylaminocarbonyl)pyridinesulfonamide can be prepared, as described in USSN 966,258, by the reaction of a pyridinesulfonamide, an alkyl isocyanate and an anhydrous base in an anhydrous solvent. Similarly, the preparation of the furan sulfonyl isocyanates is described in U.S. Patent 4,127,405 (1978); the thiophene and naphthalene sulfonylisocyanates can be prepared as shown in Equations 3 and 4 respectively, wherein R14, R15, R17 and R18 are as previously defined. Equation 3 EMI18.1 A mixture of the appropriate sulfonamide, e.g., an 2-alkoxycarbonyl-3-thiophene sulfonamide VI such as the methyl ester, which is known in the art, an alkyl isocyanate such as butyl isocyanate and a catalytic amount of l,4-diazat2.2.2Jbicyclooctane (DISCO) in xylene or other inert solvent of sufficiently high boiling point (e.g. - > l350C) is heated to approximately 130-1500C. Phosgene is added to the mixture until an excess of phosgene is present as indicated by a drop in the boiling point. After the mixture is cooled and filtered to remove a small amount of insoluble by-products, the solvent and alkyl isocyanate are distilled off in-vacuo leaving a residue which is the crude sulfonyl isocyanate VII. Equation 4 EMI19.1 The preparations of naphthalene sulfonylisocyanates IX can be obtained from the corresponding sulfonamides VIII. Reaction conditions for the phosgenation would be the same as that for the thiophene sulfonamides in Equation 3. The phenyloxysulfonylisocyanates of Formula XI are readily prepared from the corresponding phenols of Formula X as taught in U.S. 4,191,553 and as shown in Equation 5. Reaction of X with chlorosulfonylisocyanate in a high boiling solvent, for example, dichlorobenzene, toluene or xylene, will produce the sulfonylisocyanate of Formula XI. Equation 5 EMI19.2 Arylsulfonylisothiocyanates of Formula III (W=S) can be prepared by treatment of sulfonamides with carbon disulfide and potassium hydroxide followed by reaction of the dipotassium salt with phosgene according to the teaching of K. Hartke, Arch. Pharm. 229, 174 (1966). Pyridine sulfonylisothiocyanates can be prepared according to the procedure taught by K. Dickere and E. Kuhle-in U.S. Patent 3,346,590. A suitable pyri dinesulfonyliminodithiocarbonate is reacted with phosgene in the presence of a solvent such as toluene or xylene. The thiophene and furan sulfonylisothiocyanate intermediates of Formula XIII prepared according to Equations 6 and 7 are useful for the preparation of compounds of Formula I where W=S. Equation 6 EMI20.1 The substituted sulfonamide is dissolved in dimethylformamide (DMF) with an equivalent amount of carbon disulfide and two equivalents of potassium hydroxide are added portionwise at room temperature. The mixture is stirred for 1-8 hours and diluted with ethyl acetate, ethyl ether or similar aprotic solvent to cause the dipotassium salt of the dithiocarbamic acid to precipitate. The salt is isolated, dried and suspended in an inert solvent such as xylene, benzene, carbon tetrachloride or methylene chloride. Phosgene is added to the stirred suspension at or below room temperature and the mixture stirred for 1-3 hours. In place of phosgene, a chloroformic ester (e.g. methyl chloroformate), phosphorous pentachloride, sulfuryl chloride or thionyl chloride can be used. The sulfonylisothiocyanate which is formed is usually soluble in the solvent and is isolated by filtering off the insoluble potassium chloride and concentrating the filtrate. These isothiocyanates tend to be unstable and dimerize readily, (Equation 7), however, the dimers can be used in the same manner as the parent isothiocyanates for the purposes of this invention. Equation 7 EMI21.1 The naphthalene sulfonylisothiocyanate intermediate XIV may also be prepared from the sulfonamide VIII according to Equation 8 and following similar reaction conditions as that in Equation 6. These isothiocyanates may also be unstable and dimerize, however, these dimers can be used in the same way as the parent isothiocyanates for the purpose of the invention. Equation 8 EMI22.1 The preparation of sulfonamides from ammonium hydroxide and sulfonyl chloride is widely reported in the literature, e.g., Crossley et al., J. Am. Chem. Soc. 60, 2223 (1938). Certain sulfonyl chlorides are best prepared by chlorosulfonation of a substituted aromatic in carbon tetrachloride according to the teaching of H. T. Clarke et al., Org. Synth., coll. Vol. 1, 2nd Ed., 1941, p. 85. Other benzenesulfonyl chlorides are best made by diazotization of the appropriate aniline with sodium nitrite in HC1, followed by reaction of the diazonium salt with sulfur dioxide and cuprous chloride in acetic acid according to the teaching of H. L. Yale and F. Sowinski, J. Org. Chem. 25, 1824 (1960). The preparation of pyridyl sulfonyl chlorides is described in Chem. Abs. 88, 190603 m (1978). Preparations of the aryl sulfonamides are given in U.S. Patents 4,127,405 (1978) wherein R7 = H, C1-C4 alkoxy, F, C1, Br, N02, CF3; EP-A- 7687 wherein R7 = CO2R9, CO2NR21R22, C(O)SR10; Er-A 23,141 (R7 = SO2NR10R11, SO2N(OCH3)CH3); EP-A- 23,422 (R7 = OCF3, OCHF2, OCF2CF2H, S(O)nR13 where R13 is fluorinated alkyl) .EP-A- 44,209 (R7 = CH2C02R20, CH(CH3)CO2R20, CH2S(O)nR13, CH(CH3)S(O)nR13); EP-A 44,212 (R7 = QS02R12 where Q = O or NCH3); EP-A- 44,807 (R7 = C3-C4 alkenyloxy, C1-C3 alkoxy substituted with OCH3 or OC2H5, S(O)nR13 where R13 = allyl); and EP-A 44,808 (R7 = C1-C3 alkoxy substituted with 1-5 atoms of Cl, Br or F). The arylsulfonamides wherein R7 = C3-C4 alkynyloxy may be prepared by methods taught in EP-A- 44,807. The synthesis of pyridylsulfonamides is described in G. Machek, Monatsch 2, 84 (1939); L. Thunus and C.L. Lapiere, Ann. Farn. 33, 663 (1975), and EP-A- 13,480. Equation 9 describes the procedure for making aryl and naphthalene intermediates of Formula III when R7 and R14 are S(O)nR13. The thioether of Formula XVb may be prepared from the appropriate 2-aminothio phenol or aminothionaphthalene and an alkyl halide as described in the literature, e.g., R. N. Prasad et al., Can. J. Chem. 44, 1247 (1966). The formation of the sulfonamide XVd is accomplished in the following manner. Equation 9 9a EMI24.1 A solution of the thioether of Formula XVb in a mixture of concentrated hydrochloric acid and glacial acetic acid is treated with a solution of sodium nitrite in water at -5 to 0 . After stirring for 10-15 minutes at Ob to insure complete diazotization, this solution is added to a mixture of an excess of sulfur dioxide and a catalytic amount of cuprous chloride in glacial acetic acid at 0-50. The temperature is kept at 0-5 for 1/4 to 1 hour and is then raised to 0-25a and held at that temperature for 2-4 hours. This solution is then poured into a large excess of ice water. The sulfonyl chloride products can be isolated by filtration or by extraction into solvent such as ethyl ether or methylene chloride followed by evaporation of the solvent. The amination described in step (9b) is conveniently carried out by treating a solution of the sulfonyl chloride with an excess of anhydrous ammonia. in a solvent such as ethyl ether or methylene chloride at 0-250. If the product sulfonamide is insoluble, it may be isolated by filtration followed by washing out the salts with water. If the product sulfonamide is soluble in the reaction solution, it may be isolated by filtering off the precipitated ammonium chloride and evaporating the solvent. Sulfonamides of Formula XVc wherein A' = aryl may also be prepared from the appropriate chlorobenzenesulfonamides (synthesis taught in U.S. 4,127,405) as shown in Equation 10. Heating an equimolar mixture of the appropriate sulfonamide and mercaptan in the presence of two equivalents of base will yield XVc following acidic work-up. As in Equation 9, the sulfonamides XVd can be prepared by oxidation of XVc. Equation 10 EMI25.1 Synthesis of thiophene sulfonamides of Formula XVIe and XVIf may be accomplished by the method outlined in Equation 11. The sulfonyl chlorides of Formula XVIa are described by H. D. Hartough in "The Chemistry of Heterocyclic Compounds," v. 3, Interscience Publishers, Inc., N.Y. 1952. These may be converted to the corresponding N-t-butyl sulfonamides XVIb by admixture with at least twice the equivalent amount of t-butylamine in an inert solvent, such as ether, filtration of the amine hydro chloride, and evaporation of the solvent. The lithiation of thiophenes and of aromatic N-t-butylsulfonamides with n-butyllithium, t-butyllithium, lithium diisopropylamide and lithium 2,2,6,6-tetramethyl piperidide is reviewed by H. W. Cschwend and H. R. Rodriguez in Org. React., 26, 1 (1979), and is generally carried out by cooling to -780 a solution of twice the equimolar amount of base kept under an inert atmosphere, in an ethereal solvent such as diethyl ether or THF, and adding a solution of the compound of Formula XVIb. The compounds of Formula XVTc may be prepared as shown in Equation (ill) by adding an equimolar quantity of the appropriate disulfide (R13S)2, allowing the mixture to warm to room temperature, washing the mixture with acidic brine, and evaporation of the solvent. Equation 11 (11a) EMI27.1 Alternatively, as shown in Equation (llc), in order to prepare the compounds of Formula XVId, the lithiation mixture may be treated with an equimolar quantity of sulfur dioxide, allowing the mixture to warm to room temperature, filtration of the solid precipitate, dissolution of this salt in ethanol and adding an equimolar amount of the appropriate alkyl iodide. This alkylation step may be carried out at temperatures of 25 to 780. The cooled reaction mixture may be diluted with dilute aqueous hydrochloric acid to precipitate the product XVId. The t-butyl sulfonamides of Formula XVIc and XVId may be converted to the compounds of Formulae XVIe and XVIf, respectively, by heating in methanol containing at least an equimolar quantity of hydrochloric acid, followed by concentration of the reaction mixture and precipitation of the product with ether. An alternate preparation of the thiophene sulfonamides of Formula XVIf is described in Equation 12. Equation 12 EMI28.1 (12c) EMI29.1 wherein X = C1 or Br and For13 and R17 are as previously defined. The reaction of Equation (12a) is accomplished by mixing equimolar quantities of the appropriate halide XVIg with an equimolar quantity of benzyl mercaptan in a polar solvent, such as dimethylformamide, containing an equimolar amount of a strong base, such as sodium methoxide or sodium hydride, heating at a temperature between 50 and 1200, and isolating the product by precipitation with ice-water and washing with hexane. The sulfides of Formula XVIh are converted to the sulfonyl chlorides XVIi as shown in Equation (12b) by contacting with at least three equivalents of chlorine in acetic acid according to the procedure of R. F. Langler, Can. J. Chem., 54, 498 (1976). The sulfonyl chlorides can be precipitated by the addition of ice-water to the chlorination mixture. Ammonolysis of thiophene sulfonyl chlorides gives XVIf. Compounds of Formulae XVIIb (Equation 13) wherein For13 and R17 are as previously defined may be prepared by adding twice the equimolar amount of chlorosulfonic acid, diluted in an inert solvent, such as dichloromethane, to the appropriate 3-thienyl sulfide XVIIa at temperatures between -300 and 25Q, washing the mixture with ice-water and evaporating the solvent. These may be converted to the appropriate compounds of Formula XVI Ic by treatment with ammonia. The sulfides of Formula XVIIc may be oxidized to compounds of Formula XVIId. Equation 13 (13a) EMI30.1 Also, the methods described in Equation 11 may be applied in making compounds of Formula XVIId. According to the method outlined in Equation 14, compounds of Formulae XVIIIf and XVIIIh can be prepared, wherein R'17 equals H, chlorine, or bromine, X r chlorine, bromine and R13 is as previously defined. Starting with sulfonyl chlorides of Formula XVIIIa, the dihalo-compounds may be partially dehalogenated by contacting with two equivalents of 5% sodium amalgam in an alcoholic or aqueous alcoholic solution at 25 to 780, followed by acidification of the products of Formulae XVIIIe and XVIIIg wherein Rl17 = Cl or Br. The 2-halo and 5-halo isomers may be separated by column chromatography. The totally dehalogenated compounds where R'17 = H, may be prepared by using three or more equivalents of the sodium amalgam in the reaction. These compounds may be converted to XVIIIf and XVIIIh as previously described. Equation 14 (14a) EMI32.1 (14f) EMI33.1 Precursors to the required thiophene sulfonyl chlorides and sulfonamides are prepared by a variety of synthetic routes depending on the chemical properties of the substituent and its position on the thiophene ring. Direct sulfonation or chlorosulfonation to sulfonic acid or sulfonyl chloride derivatives can be carried out according to the references cited in "Thiophene and its Derivatives," H. D. Hartough, Interscience, New York, 1952. The structure of sulfonation products of 3-alkyl thiophenes has been reported as uncertain. Nuclear magnetic resonance studies indicate the chlorosulfonation occurs predominantly at the 2- rather than the 5-position. Sulfonic acids are readily converted to sulfonyl chlorides, using methods well known in the art, by chlorinating agents such as phosphorus pentachloride, phosphorus oxychloride or thionyl chloride. A mixture of sulfuryl chloride in dimethylformamide can also be used to prepare thiophenesulfonyl chlorides of active thiophene intermediates according to the method of E. Testa et al., Helv. Chim. Acta., 47, 766 (1963). Other intermediates can be prepared via lithiation reactions. A review of this chemistry appears in Organic Reactions, Vol. 26., Gschwind, H. W. and Rod- riguez, H. R., John Wiley and Sons, Inc., New York, 1979. examples of the application of this chemistry to the preparation of intermediates used here is shown in the following equations. .Equation 15 shows the preparation of sulfamyl thiophene sulfonamides via lithiated intermediates. Equation 15 EMI34.1 As shown in Equation 15, 3-bromothiophene is converted to 3-lithiothiophene at -780 in an inert solvent such as tetrahydrofuran and the mixture is then contacted with sulfur dioxide. The resultant lithio sulfinate is stirred at room temperature in acetic acid or aqueous 2-propanol with N-chlorosuccinimide to yield the 3-thiophenesulfonyl chloride IXXb. This product is then contacted with an amine, HNRlORll wherein Rl and Rll are as previously defined. The 3-thiophenesulfonamide IXXc, thus formed is reacted with butyl lithium at -40 to 0 C followed by sulfur dioxide to form the lithio 3-sulfamyl-2thiophenesulfinate IXXd which is converted to the sulfonyl chloride as described above. Conversion of this sulfonyl chloride to the sulfonamide and sulfonylisocyanate is carried out as previously described. The synthesis of other intermediates via lithiation is shown in Equation 16, wherein R18 is optionally C1, Br, C1-C4 alkyl, C3 alkenyl or OCH3. Equation 16 EMI35.1 The reactions described in Equation 16 are carried out in the same manner as those described in Equation 15 as would be expected by one skilled in the art. Displacement of activated halogen atoms from the thiophene nucleus by benzyl mercaptan and chlorination of the resulting product is also a useful route to intermediates for compounds of this invention as illustrated by Equation 17. Equation 17 EMI36.1 The reaction of benzyl mercaptan with a halothiophene, wherein the halo atom is susceptible to replacement by a nucleophile, is best carried out in an inert polar, high boiling solvent such as dimethylformamide or N-methylpyrrolidone at reflux in the presence of a copper catalyst over six to forty-eight hours. The thioether intermediate XXIb is converted to the sulfonyl chloride XXIc by passing chlorine gas into aqueous hydrochloric acid or acetic acid solution or suspension of XXIb. Disulfides such as structure XXII, reported by Henriksen and Autruys, Acta. Chem. Scands., 24, 2629 (1970), are also useful intermediates for conversion to sulfonyl chlorides as shown in Equation 18. Equation 18 EMI37.1 The chlorination shown in Equation 18 is carried out in the same manner as described for the chlorination of structure XXIb. Alternatively, the diazotization reaction of thiophene amines to sulfonyl chlorides such as structure XXIV shown in Equation 19 are carried out according to the general procedure of H. L. Yale and F. Sowinski, J. Org. Chem., 25, 1824 (1960). Equation 19 EMI37.2 The o-alkoxymethyl nitrobenzenes XXVb are in turn prepared via "Williamson Synthesis", according to Equations 20a or 20b. Equation 20a EMI37.3 Equation 20b EMI38.1 R' = C1-C2 alkyl. WWilliamson Synthesis" has been widely used for the preparation of ethers as reviewed by W. Theilheimer, Syn. Methods of Org. Chem., Vol. VII, p. 112. Alternatively, o-alkoxymethyl methylbenzenesulfonyl chlorides, XXYf, can be obtained from an appropriately substituted 6-hydroxy-o-toluenesulfonic acid-&alpha;-sultone, XXVd, via ring-opening reaction with an alkoxide anion as depicted in Equations 20c and 20d. Equation 20c EMI38.2 Equation 20d EMI38.3 Reaction 20c is closely related to the alkylation of acyloxides and acetamide with sultones as disclosed by J. H. Helberger et al., Ann., 565 22 (1949). Conversion of the sulfonic acid salt to the sulfonyl chloride is then carried out according to the teaching of Org. Synthesis, Coll. Vol. IV, 846, 693. Benzenesulfonamides of Formula XXVIb can also be derived from compound XXVIa as illustrated in Equation 21. Equation 21 EMI39.1 The o-alkoxyethylbenzenesulfonamides of Formula XXVIIb can be prepared from the appropriate benzenesulfonyl chlorides of Formula XXVI Ia via lithiation chemistry as shown in Equation 22. Reactions of this type are well known in the literature and have been reviewed in Organic Reactions, Vol. 26, Gschwend, H. W. and Rodriguez, H. R., John Wiley and Sons, Inc., New York, 1979. Equation 22 EMI40.1 Preparation of o-sulfamylbenzoic acid esters, from saccharin or sulfobenzoic acid anhydride is well known in the art, e.g., B. Loev and M. Kormendy, J. Org. Chem. 27, 1703 (1962). The esters can be readily reduced to the ethers with diborane in a suitable organic solvent, e.g., tetrahydrofuran, in the.presence of fifteen fold excess of boron trifluoride etherate under reflux for 18 hours, as described by R. P. Graber and M. B. Meyers, J. Org. Chem., 26, 4773 (1961). Most generally, the naphthalene sulfonamides may be prepared from the sulfonyl chlorides XXVIIIb (Equation 23) as described in "Preparative Organic Chemistry", ed. G. Hilgetag and A. Martini, J. Wiley and Sons, New York (1972). The sulfonyl chlorides may be prepared by chlorination of the sulfonic acids XXVII Ia by methods described by Hilgetag and Martini, op. cit. The preparation of these acids is described in the art. These compounds may be further transferred by methods known in the art to yield other disclosed sulfonic acids. Equation 23 EMI41.1 The desired sulfamyl naphthalene sulfonamides can be prepared by methods analogous to those taught in European Patent 23,141. The benzylsulfonamides of Formula XXIXd are most easily prepared as shown in Equation 24. The appropriately substituted toluene derivatives of Formula XXIXa are brominated and then reacted with thiourea to give the thiouronium salts of Formula XXIXb. Preparation of the sulfonyl chlorides of Formula XXI Xc is readily accomplished by oxidation/chlorination of XXIXb tfor the preparation and oxidative chlorination of thiouronium salts see: T. B. Johnson and 3. M. Sprague, 3. Am. Chem. Soc., 58, 1348 (1936); ibid., 59, 1837, 2439 (1937); ibid., 61, 176 (1939)1. Amination of XXIXc will give the sulfonamides of Formula XXIXd. Equation 24 EMI42.1 Alternatively, the benzyl chlorides of formula XXI Xe can be converted to the benzylsulfonamides of Formula XXIXd as shown in Equation 25. Equation 25 EMI43.1 Phosgenation of XXIXd to the corresponding benzylsulfonylisocyanates of Formula XXIXf proceeds readily as shown in Equation 26. (See Equation 3 for complete details.) Equation 26 EMI43.2 Preparations of 3-amino-1,2,4-triazoles are known in the art and 1,2,4-triazoles are reviewed in The Chemistry of Heterocyclic Compounds "Triazoles 1,2,4" tzohn Wiley & Sons, New York, 1981). Commonly used starting materials containing nitrogen are N-aminoguanidine, hydrazine, alkylhydrazines, cyanamide, ethyl cyanoacetimidate, dimethyl cyanodithio imiducarbonate, dimethyl cyanoimidocarbonate, ethoxymethylenecyanamide, and acylhydrazines. Some literature syntheses are illustrated below. Using these techniques or suitable modifications that would be apparent to one skilled in the art, the 3-amino-1,2,4triazole intermediates can be readily prepared. Heating equimolar amounts of ethyl propionimidate hydrochloride and N-aminoguanidine nitrate in pyridine gives 3-amino-5-ethyltriazole; German Patent 1,073,499 (1960); Berichte, 96, 1064 (1963). EMI44.1 Condensation of hydrazine with ethyl N-cyanoacetimidate yields 3-amino-5-methyltriazole; Journal of Organic Chemistry, 28, 1816 (1963). EMI44.2 Trifluoromethyl 3-aminotriazole can be obtained by thermal dehydration of the hydrazide of trifluoroacetic acid. Zh. Obshch. Khim., 39, 2525 (1969); Chemical Abstracts, 72: 78954v (1970). EMI44.3 U.S. Patent 2,835,581 (1958) teaches the preparation of 3-amino-5-(hydroxymethyl)triazole from N-aminoguanidine and glycolic acid and British Patent 736,568 (1955) describes the synthesis.of 3-amino-5-mercaptotriazole. EMI45.1 Condensing hydrazine with dimethyl cyanodithioimidocarbonate in acetonitrile gives 3-amino-5-methylthio1,2,4-triazole while reaction of hydrazine with dimethyl N.cyanoimidocarbonate produces 3-amino-5-methoxy-1,2,4-triazole; Journal of Organic Chemistry, 39, 1522 (1974). EMI45.2 Reaction of substituted hydrazines with N-cyano thioimidocarbonates (prepared according to the procedure given in D. M. Wieland, Ph.D. Thesis, 1971, pp. 123-124) yields disubstituted aminotriazoles as shown below. EMI46.1 Aminoimidazoles of Formula IIa and procedures for their preparation are well known in the art [e.g., 3. Orq. Chem., 29, 3118 (1964); Liebiqs Ann. Chem., 1602 (1979)]. General Reviews are available in K. Hoffmann, "Imidazole and its Derivatives," New York, Interscience, 1953; Pozharshii, Garnooskii and Simonov, Russ. Chem. Rev., 35, 122 (1966); Elderfield, "Heterocyclic Compounds", Vol. V, Wiley 1957; M. R. Grimmet, "Advances in Heterocyclic Chemistry," Volume 12, Academic Press, 1970. For example, 4,5-dialkyl-2-aminoimidazolium chloride was prepared by the method described by B. T. Storey, W. W. Sullivan, and C. L. Moyer in J. Org. Chem., 29, 3118 (1964). Acetoin and formamide were heated at reflux and the mixture distilled to af-ford 4,5-dialkylimidazole (Equation 26). Equation 26 EMI46.2 wherein R1 and R2 are independently CH3 or C2H5. p-8romobenzenediazonium chloride was allowed to react with 4,5-dialkylimidazole to afford 2-(±-bromo- benzeneazo)-4,5-dialkylimidazole (Equation 27). Equation 27 EMI47.1 wherein R1 and R2 are independently CH3 or C2H5. Reduction of the azo compound with stannous chloride in hydrochloric acid afforded 2-amino-4,5dialkylimidazole and p-bromoaniline (Equation 28). The aminoimidazole was separated and isolated as its hydrochloride salt. Equation 28 EMI47.2 wnerein R1 and R2 are independently CH3 or C2H5. 4(5)-Alkyl-5(4)-alkoxyimidazole was prepared by the procedures described by U. Scholikopf and K. Hantke in Liebigs Ann. Chem., 1602, (1979), F. Becke and P. Passler in Liebigs Ann. Chem., 735, 27 (1970), and K. Hantke, U. Schollkopf and H.-H. Hausberg in Liebigs Ann. Chem., 1531 (1974). By these methods, a cyanohydrin was condensed with formamide at 100-1200C to afford 2-formylaminoalkylnitrile (Equation 29a). This was dehydrated with phosphorus oxychloride to give 2-isocyanoalkylnitrile (Equation 29b). This isocyanide was allowed to react with methanol in the presence of potassium carbonate as catalyst to afford 4(5)-alkyl-5(4)-alkoxyimidazole (Equation 29c). Equation 29 EMI48.1 wherein R1 is CH3 or C2H5; and R2 is CH3O, C2H50 or CH3S. 2-Amino-4(5)-alkyl-5(4)-alkoxyimidazole can be prepared by procedures analogous to those described above for the preparation of 2-amino-4,5-dialkylimidazole. For example, 4(5)-alkyl-5(4)-alkoxyimidazole may be coupled with e-bromobenzenediazonium chloride to give 2-(p-bromobenzeneazo)-4(5)-alkyl-5(4)-alkoxy- imidazole (Equation 30a). This azo compound may be reduced with stannous chloride in hydrochloric acid to afford 2-amino-4(5)-alkyl-5(4)-alkoxyimidazole (Equation 30b). Equation 30 EMI49.1 wherein R1 is CH3 or C2H5; and 2 is CH3O, C2H5 or CH3S. Aminoimidazoles of Formula IIa wherein R is alkyl can be prepared by N-alkylation of the appropriate imidazole with an equimolar amount of alkyl iodide in the presence of base (Equation 31). Equation 31 EMI49.2 The N-alkyl products can be separated by distillation, crystallization, or chromatography. The 2-amino group can be introduced by successive diazo coupling and reduction by the methods described above. Although the 4,5-disubstituted imidazoles obtained by the methods described herein are represented by Structure A in the discussion and examples, it should be understood that the tautomeric or isomeric identity-of the products is uncertain and the compounds of this invention include both tautomers or isomers A and B as they occur. EMI50.1 2-Amino-4,5-dimethoxyimidazole can be prepared by condensing guanidine with dimethyloxalyl diimidate (DMODI) and subsequent reduction by methods analogous to those taught in J. Org. Chem., 44, 818 (1979) (Equation 32). Equation 32 EMI50.2 The following examples teach the preparation of compounds of this invention in more detail. Unless otherwise indicated, all parts are by weight and temperatures in OC. Example I 2-[[(5-Methylthio-lH-1,2,4-triazol-3-yl)amino- carbonyl]aminosulfonyl]benzoic acid, methyl ester To a mixture of 5.0 grams (0.0385 mole) 3-amino 5-methylthio-lH-1,2,4-triazole (Aldrich Chemicals) and 75 ml of dry methylene chloride stirring in a 200 ml RB single neck flask, 10.5 grams of 2-(methoxycarbonyl)benzenesulfonylisocyanate was added at ambient temperature; a clear solution gradually formed. After stirring overnight at room temperature, the white solid which precipitated was filtered and washed with methylene chloride, yield 11.7 grams, m.p. 147-1530. NMR (tfa-D): 6 2.85 (s, 3H, SCH3), 4.10 (s, 3H, CO2CH3), 7.60-8.55 (m, ArH). IR (Nujol): 3.0-3.20 (NH), 5.75 (C=O), 6.20 (C=N) microns. Example II 2-[E(1-Methyl-5-methylthio-lH-1,2,4-triazol-3-yl)amino- carbonyl]aminosulfonyl]benzoic acid, methyl ester Method A: Methyl iodide (0.6 ml) was added by syringe at ambient temperature to a stirred mixture of 0.8 grams (0.0022 mole) of methyl 2.[(5.methylthio-lH- 1,2,4-triazol-3-yl)aminocarbonyl]aminosulfonylbenzoate and 0.6 grams of potassium carbonate in 30 ml of acetone in a 100 ml RB single neck flask. The mixture was stirred at room temperature overnight. The reaction mixture was then poured into 250 ml of ice water and acidified to pH 3-4 with glacial acetic acid. After extracting the aqueous mixture with 1:1 mixture of ethyl acetate and ethyl ether, the organic layer was washed with brine, dried (MgSO4), filtered, and the solvent evaporated to dryness to yield a white solid residue which was suspended in acetonitrile, filtered, and recrystallized from the acetonitrile; yield 0.3 g, m.p. 198-2000. NMR (tfa-D): s 2.95 (s, 3H, SCH3), 4.0 (s, 3H, CH3), 4.15 (s, 3H, C02CH3), 7.80-8.60 (m, ArH). IR (Nujol): 5.75-5.85 (C=O), 6.30 (C=N), 13.10, 13.55 microns. Method B: To 1.0 gram (0.0069 mole) of 3-amino l-methyl-5-methylthio-lH-1,2,4-triazole stirring in 15 ml of dry methylene chloride, 3.0 grams of 2-(methoxycarbonyl)benzenesulfonylisocyanate was added at ambient temperature and a cloudy solution immediately formed followed by precipitation of a white solid. The white suspension was stirred at room temperature overnight. Chlorobutane (4 ml) was added to the mixture and the white solid filtered, washed with methylene chloride followed by a chlorobutane wash, yield 2.0 g, m.p. 198-2000 (recrystallized from acetonitrile). The spectral characteristics and melting points were identical to the solid obtained in Method A. A mixed melting point was not depressed. Example III 3-Amino-l-methyl-5-methylthio-lH-1,2,4-triazole At 00, 6.5 grams of methyl hydrazine was added dropwise to a stirred suspension of 20.0 grams (0.137 mole) dimethyl cyanodithioimidocarbonate in 35 ml of acetonitrile. A yellow solution immediately formed after the addition followed by precipitation of a white solid. The ice bath was removed, and upon warming to room temperature a yellow solution formed which was stirred at room temperature overnight. After stirring overnight, a solid precipitated which was filtered, washed with cold acetonitrile, followed by l-chlorobutane, yield 8.5 grams, m.p. 104-1090. The literature ±Journal of Organic Chemistry, 39, 1522 (1974)) reported a similar melting point of 103-1060 for the title compound, however, a different isomeric structure was assigned to the compound (5-amino-1methyl-3-methylthio-1H-1,2,4-triazola). The assignment of 3-amino-1-methyl-5-methylthio-1H-1,2,4-triazole as the correct structure was verified by X-ray crystal structure analysis. Example IV 2-[[(1,5-Dimethyl-1H-1,2,4-triazol-3-y1)amino carbonYlzaminosulfonyl]benzoic acid, methyl ester In 20 ml of acetonitrile at room temperature, 0.63 grams of 3-amino-1,5-dimethyl-lH-1,2,4-triazole [Journal of Organic Chemistry, 39, 1522 (1974)) and 1.49 grams of 2-(methoxycarbonyl)benzenesulfonyliso- cyanate were stirred for 12 hours. The white solid which precipitated was filtered and washed with ether to yield 1.3 grams of the title product melting at 175-178 . Example V 2-[[(1-Methyl-5-methylthio-lH-1,2,4-triazol-3-yl)aminoN carbonyllaminosulfonyl]benzoic acid, 2-propyl ester A mixture of 0.7 grams (0.00486 mole) of 3-amino1-methyl-5-methylthio-1H-1,2,4-triazole and 4.0 grams of 2-(isopropoxycarbonil)benzenesulfonylisocyanate was stirred in 12 ml of dry methylene chloride at ambient temperature overnight. After addition of 4 ml of l-chlorobutane, a white solid precipitated which was filtered, washed with l-chlorobutane and dried, yield 1.3 grams, m.p. 192-1940. NMR (tfa-D): C 1.55 (d, 6H, 2CH3), 2.90 (s, 3H, SCH3), 3.95 (s, 3H, N-CH3), 4.90-5.40 (m, 1H, C02CH), 7.60-8.50 (m's, ArH). IR (Nujol): 2.95 (NH), 5.75 (C=O), 6.30 (C=N), 13.10, 13.50 microns. Example VI 2-E(1-Methyl-5-methylthio-lH-1,2,4-triazol-3-yl)amino- carbonyl ]-2-nitrobenzenesulfonamide After the addition of 3.0 grams 2-nitrobenzenesulfonylisocyanate to 0.7 grams (0.00486 mole) 3-amino l-methyl-5-methylthio-lH-1,2,4-triazole stirring in 15 ml of dry methylene chloride, a solid precipitated and the suspension was stirred at room temperature overnight. The solid was filtered and washed with l-chlorobutane to yield 1.6 grams of product, m.p. 220-2130. NMR (tfa-O): S 2.90 (s, 3H, SCH3), 4.00 (s, 3H, N-CH3), 7.85-8.60. (m, ArH). IR (Nujol): 3.0-3.20 (NH), 5.80 (C=O), 6.25 (C=N), 12.70, 13.45, 13.60 microns. Example VII 2-EE(1-Ethyl-5-methylthio-lH-1,2,4-triazol-3-yl)amino- carbonyl]aminosulfonsl]benzoic acid, methyl ester To a stirred mixture of 1.0 gram (0.0027 mole) of methyl 2-E(5-methylthio-lH-l,2,4-triazol-3-yl)amino- carbonyl]aminosulfonylbenzoate and 0.7 grams of potassium carbonate in 30 ml of acetone at room temperature, 0.8 ml of ethyl iodide was added by way of syringe and the resulting white suspension stirred 3 days. The mixture was poured into 250 ml of ice water and acidified to pH 3-4 with glacial acetic acid. The aqueous acidic mixture was extracted with 1:1 mixture of ethyl ether/ethyl acetate and the extract washed with brine, dried (MgSO4), and evaporated to yield a white solid residue which was suspended in acetonitrile and filtered, yield 0.3 grams, m.p. 188-191 . NMR(tfa-O): s 1.45 (t, 3H, CH3), 2.80 (s, 3H, SCH3), 4.05 (s, 3H, C02CH3), 4.25 (q, 2H, CH2), 7.60-8.45 (m, ArH). Example VIII 3-Amino-5-methoxy-1-methyl-1H-1,2,4-triazole Methylhydrazine (98%, 6.30 g, 0.136 mol) was added dropwise to a solution of dimethyl-N-cyanothioimidocarbonate (17.3 g, 0.133 mol, prepared according to procedure given in D. M. Wieland, Ph.D. Thesis, 1971, pp. 123-124.) in acetonitrile (35 ml) at -5-0 with stirring under nitrogen. The reaction mixture was allowed to warm to room temperature and stirred for 2 days. Isolation of the product by filtration and washing with acetonitrile gave 12.7 g of a white powder, m.p. 177-1800. NMR (DMSO/CDC13): # 3.35 (s, N-CH3), 3.95 (s, 0-CH3); and 5.0 (broad, NH2). Example IX 2-EE(5-Methoxy-l-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl]aminosulfonyl]benzoic acid, methyl ester To a solution of 2-(methoxyzarbonyl)benzenesul- fonylisocyanate (80%, 1.41 g, 4.7 mmol) in methylene chloride (10 ml) at room temperature under nitrogen was added 3-amino-5-methoxy-1-methyl-lH-1,2,4-triazole (0.50 9, 3.9 mmol). DABCO (catalytic amount) was added, and the reaction mixture was stirred for 3 days. Isolation of the product by filtration and washing with methylene chloride gave 1.05 g of a white powder, m.p. 177-1800. NMR (CDC13/DMSO): C 3.5 (s, N-CH3); 3.9 (s, CO2CH3); 4.1 (s, O-CH3); 7.5-7.8 (m, Ar-H); 8.1-8.4 (m, Ar-H); 9.7 (broad, NH); and 11.0 (broad, NH). IR(KBr) 3150 (NH), 1740 (c=o), 1700 (c=o), 1600, 1530, 1475, 1420, 1360 (SO2), 1340, 1295, 1260, 1180 (SO2), 1115 and 1050 cm-1 Example X Preparetion of 2-[[(4,5-Dimethyl-1H-imidazol-2-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester (1) A mixture of 2-(methoxycarbonyl)benzenesulfonyl isocyanate (0.96 g; 0.0040 mol), 2-amino-4,5-dimethylimidazolium chloride (0.59 g; 0.0040 mol), 1,5 diazabicyclo[4.3.0)non-5-ene (0.05 g; 0.0004 mol) and acetonitrile (25 ml) was stirred at room temperature for 91 hours. The precipitate was filtered and washed successively with n-butyl chloride, 2% HC1, and water, then dried under vacuum at 600C to afford 1 as a white solid, m.p. 172-1770C; yield 0.5 g. NMR: s 2.0 (s, ArCH3); 4.0 (s, C02CH3); 7.2 (bs, NH); and 7.4-8.4 (m, ArH). By application of one or more of the procedures of Examples I-X and/or the methods described above and using the appropriate reactants, the compounds of Tables 1 to 18 can be prepared. Table 1 EMI57.1 R1 R2 R3 w R7 R8 m.p.( C) H n-C3H7 H O C02CH3 H H C2H5 H O C 2C2H5 H H CH(CH3)2 H O S02CH3 H CH3 C2H5 H O CO2CH3 H CH3 C2H5 H S C1 H CH3 C2H5 CH3 O CO2CH3 H CH3 C2H5 CH3 O SO2CH3 H CH3 C2H5 H O CF3 H CH3 C2H5 H O Br H CH3 C2H5 H O Cl H CH3 C2H5 H S CH3 H CH3 C2H5 H O C2H5 H CH3 C2H5 H O NO2 H CH3 C2H5 H O SO2(CH2)2CH3 H CH3 C2H5 H O SO2N(CH3)2 H CH3 C2H5 CH3 O NO2 H CH3 C2H5 H O OCH3 H OCH3 C2H5 H O CO2CH(CH3)2 H CH3 C2H5 H O CO2CH2CH=CH2 H OCH3 C2H5 H O OCF2CF2H H CH3 C2H5 H O CH2OCH3 H OCH3 C2H5 H O OSO2CHCl2 H CH3 C2H5 H O CF3 H CH3 C2H5 H 0 SC2H5 H OCH3 C2H5 H O OSO2C2H5 H Table 1 (continued) R1 R2 R3 w R7 R8 OCH3 C2H5 H O OSO2CH2CF3 H CH3 C2H5 H O CO2CH2CH2Cl H OCH3 C2H5 H O OSO2CH2CH2OCH3 H OC2H5 CH3 H O SIO2N(OCH3)CH3 H C2H5 CH3 H O CO2CH3 H 165-166 C2H5 CH3 H O Br H C2H5 CH3 H O NO2 H C2H5 CH3 CH3 O CO2CH3 H C2H5 CH3 CH3 O SO2CH3 H OC2H5 CH3 CH3 O CO2CH2CH2OCH3 H OC2H5 CH3 CH3 O OSO2CH2(CH2)2OCH3 H C2H5 CH3 H S CH3 H C2H5 CH3 H S Cl H C2H5 CH3 CH3 O CH3 H C2H5 CH3 H O CO2CH(CH3)2 H C2H5 CH3 H O Cl H C2H5 CH3 H O CO2CH2CH=CH2 H OC2H5 CH3 H O OSO2CH2CF2H H OC2H5 CH3 H O OSO2CCl3 H OC2H5 CH3 H O OSO2CHCL2 H C2H5 CH3 H O OSO2CH3 H C2H5 CH3 H O CH2OC2H5 H C2H5 OH3 H O SO2C2H5 H OC2H5 CH3 H O OSO2CF3 H C2H5 CH3 H O OCF3 H OC2H5 CH3 H O OCH3 H C2H5 CH3 H O N02 5-CF3 C2H5 CH3 H O NO2 3-Cl C2H5 CH3 H O Cl 6-NO2 C2H5 OH3 H O CF3 5-NO2 CH3 C2H5 H O Cl %-Cl OCH3 C2H5 H O NO2 5-Cl Table 1 (continued) R1 R2 R3 W R7 R8 m.p( C) CH3 C2H5 H O SO2N(CH3)2 3-Cl OC2H5 CH3 H O CO2CH3 3-C2H5 C2H5 CH3 H O CI 3-Br OC2H5 CH3 H O Cl 5-Br O2H5 CH3 H O N02 6-F OC2H5 CH3 H O Cl 5-F C2H5 CH3 H O Cl 4-F OC2H5 CH3 H O Br 3-F C2H5 CH3 H O NO2 5-NO2 C2H5 CH3 H O C02CH3 3-CF3 OC2H5 CH3 H O CH3 3-NO2 C2H5 C2H5 H O CO2CH3 H C2H5 CH3 H O C02C2H5 H C2H5 C2H5 H S Cl H C2H5 C2H5 H O NO2 H C2H5 C2H5 H S CH3 H C2H5 C2H5 H O CO2CH2CH=CH2 H C2H5 C2H5 H O CO2CH(CH3)2 H C2H5 C2H5 H O SO2CH3 H C2H5 C2H5 H O SO2(CH2)2CH3 H OC2H5 C2H5 H O SO2CHF2 H C2H5 C2H5 H O SO2N(CH3)2 H C2H5 C2H5 H O SO2N(OCH3)CH3 H OC2H5 C2H5 H O OSO2CH3 H C2H5 C2H5 H O (CH2)2CH3 H C2H5 C2H5 H O OC2H5 H C2H5 C2H5 H O SCH3 H CH(CH3)2 CH3 H O NO2 H n-C3H7 CH3 H O Cl H CH2CH(CH3)2 CH3 H O CO2CH3 H CH2CH=CH2 CH3 H O CF3 H CH2C(CH3)=CH2 CH3 H O CO2CH3 H TABLE 1 (continued) R1 R2 R3 W R7 R8 m.p.( C) CH2C#CH CH3 H O CO2CH3 H CH2C#CCH3 CH3 H O CO2CH3 H OCH3 CH2CH#CH2 H O CO2C2H5 H CH3 CH2C(CH3)=CH2 H O SO2CH3 H CH3 CH2CH=CHCH3 H O CO2CH3 H CH3 CH2C#CCH3 H O CO2H3 H OCH3 CH2C#CH H O NO2 H SCH3 CH3 CH3 O CO2CH3 H SCH3 CH3 H O SO2CH3 H 208-213 SCH3 CH3 CH3 O NO2 H SCH3 CH3 CH3 O SO2N(CH3)2 H SCH3 CH3 CH3 O SO2N(CH3)C2H5 H SCH3 CH3 H S CH3 H SCH3 CH3 H S NO2 H SCH3 CH3 H O Cl H 230-237 SCH3 CH3 H O OSO2CH3 H SCH3 CH3 H O CO2CH2CH2CH3 H SCH3 CH3 H O CO2CH2CH=CH2 H 160-163 SCH3 CH3 H O CO2CH2CH2Cl H SCH3 CH3 H O CO2CH2CH2OCH3 H SCH3 CH3 H O CO2CH(CH3)C2H5 H SCH3 CH3 H O CO2(CH2)3CH3 H SCH3 CH3 H O OSO2(CH2)3CH3 H SCH3 CH3 H O OSO2(CH2)3OCH3 H SCH3 CH3 H O CH2OCH3 H SCH3 CH3 H O OSO2CH2CF2H H SCH3 CH3 H O H H SCh3 CH3 H O F H SCH3 CH3 H O H 4-F SCH3 CH3 H O H 5-F SCH3 CH3 H O OSO2CH2CCl3 H SCH3 CH3 H O OSO2CH2CHcl2 H SCH3 CH3 CH3 O SO2CH3 H Table 1 (continued) R1 R2 R3 W R7 R8 m.p.( C) SCH3 CH3 H O OSO2CF3 H SCH3 CH3 H O OS02CHC12 H SCH3 CH3 H O SO2(CH2)2CH3 H SCH3 CH3 H O S02N(CH3)2 H SCH3 CH3 H O SO2N(C2H5)2 H SCH3 CH3 H O SO2N(CH3)[CH(CH3)2] H SCH3 CH3 H O SO2CH(CH3)2 H SCH3 CH3 H O CH2OC2H5 H SCH3 CH3 H O C2H5 H SCH3 CH3 H O CF3 H SCH3 CH3 H O Cl 5-Br SCH3 CH3 H O Cl 6-Cl SCH3 CH3 H O NO2 5-Cl SCH3 CH3 H O CO2CH3 3-Br SCH3 CH3 H O SO2CH3 4-OCH3 SCH3 CH3 H O CO2CH3 4-OCH3 SCH3 CH3 H O Cl 5-NO2 SCH3 CH3 H O SO2N(CH3)2 5-NO2 SCH3 CH3 H O Cl 5-CH(CH3)2 SCH3 CH3 H O NO2 5-C2H5 SCH3 CH3 H O N02 5-CF3 SCH3 CH3 H O NO2 3-CF3 SCH3 CH3 H O SCF3 H SCH3 CH3 H O OCF3 H SCH3 CH3 H O NO2 6-F SCH3 CH3 H O Cl 5-OC2H5 SCH3 CH3 H O Br 5-NO2 SCH3 CH3 H O NO2 3-F SCH3 CH3 H O Cl 5-F SCH3 CH3 H O NO2 6-F SCH3 CH3 H O Cl 4-F SCH3 CH3 H O OSO2CHF2 H Table 1 (continued) R1 R2 R3 W R7 R6 m.p.( C) SCH3 CH3 H O OSO2(CH2)3Br H SC2H5 CH3 H O CO2CH3 H 205-208 SC2H5 CH3 H O SO2CH3 H SC2H5 CH3 CH3 O SO2CH3 H SC2H5 CH3 H O NO2 H 186-190 SC2H5 CH3 H S Cl H SC2H5 CH3 H S CH3 H SC2H5 CH3 H O CF3 H SC2H5 CH3 H O CO2CH(CH3)2 H 152-156 SC2H5 CH3 H O CO2CH2CH=CH2 H 172-174 SC2H5 CH3 CH3 O NO2 H SC2H5 CH3 H O CH2OCH3 H SC2h5 CH3 H O SO2C2H5 H SC2H5 CH3 H O SO2N(CH3)C2H5 H SC2H5 CH3 H O Br H SC2H5 CH3 H O OCF3 H SCH3 C2H5 H O CO2CH3 H SCH3 C2H5 H O Cl H SCH3 C2H5 H O NO2 H SCH3 C2H5 H S Br H SCH3 C2H5 H S CH3 H SCH3 C2H5 H O CF3 H SCH3 C2H5 H O OCH3 H SCH3 C2H5 H O CO2(CH2)2CH3 H SCH3 C2H5 H O OSO2(CH2)2CH3 H SCH3 C2H5 H O SO2N(CH3)C2H5 H SCH3 C2H5 H O SO2N(OCH3)CH3 H SCH3 C2H5 H O SO2(CH2)2CH3 H SCH3 C2H5 H O OCHF2 H SCH3 C2H5 H O CH(CH3)2 H Table 1 (continued) R1 R2 R3 W R7 R8 m.p.( C) SCH3 C2H5 H O SCF3 H SCH3 C2H5 H O OSO2(CH2)2OCH3 H SCH3 C2H5 H O SC2H5 H S(CH2)2CH3 CH3 H O Cl H S(CH2)2CH3 CH3 H O CO2CH3 H SCH(CH3)2 CH3 H O CO2C2H5 H S(CH2)3CH3 CH3 H O SO2CH3 H SCH(CH3)C2H5 CH3 H O CO2C2H5 H SCH2CH=CH2 CH3 H O NO2 H SCH2C(CH3)=CH2 CH3 H O CO2CH3 H SCH2CH=CHCH3 CH3 H O SO2CH3 H SCH2CO2CH3 CH3 H O Cl H SCH2CO2(CH2)3CH CH3 H O Br H SCH(CH3)CCO2CH3 CH3 H O NO2 H SCH2C#CH CH3 H O CO2CH3 H SCH2#CCH3 CH3 H O CO2CH3 H CH3 CH2OCH3 H O CO2C2H5 H CH3 CH2OCH3 H O SO2C2H5 H CH3 CH2SCH3 H O CH2OCH3 H CH3 CH2CH2OCH3 H O Cl H CH3 CH2CH2SCH3 H O SO2CH3 H CH2OC2H5 CH3 H O CH3 H CH2OC2H5 CH3 H O CO2CH(CH3)2 H CH2OC2H5 CH3 CH3 O CO2CH3 H CH2OCH(CH3)2 CH3 H O Br H CH2O(CH2)3CH3 CH3 H O SO2C2H5 H CH2CH2OCH3 CH3 H O NO2 H CH2CH2OC2H5 CH3 H O CO2CH3 H CH2CH2O(CH2)2CH3 CH3 H O CO2CH3 H OCH3 CH3 H S C1 H OCH3 C2H5 H S NO2 H Table 1 (continued) R1 R2 R3 W R7 R8 m.p.( C) OCH3 C2H5 H S CH3 H OCH3 CH3 H S CF3 H OCH3 CH3 H S Br H OCH3 CH3 CH3 O CO2CH3 H OCH3 CH3 CH3 O SO2CH3 H OCH3 CH3 CH3 O SCH3 H OCH3 CH3 H O OSO2(CH2)3OCH3 H OCH3 C2H5 H O OSO2CHCl2 H OCH3 C2H5 H O OSO2CH2CF2H H OCH3 C2H5 H O OCF3 H OCH3 C2H5 H O SCHF2 H OCH3 C2H5 H O OSO2CH(CH3)2 H OC2H5 CH3 H O H H OC2H5 CH3 H O F H OC2H5 CH3 H O CO2CH3 3-Br OC2H5 CH3 H O SO2CH3 H 190-108 OC2H5 CH3 H O S(CH2)3CH3 H OC2H5 CH3 H O OSO2(CH2)3CH3 H OC2H5 CH3 H O OCF3 H OC2H5 CH3 H O SCF3 H OC2H5 CH3 H O OCHF2 H OC2H5 CH3 H O SCHF2 H OC2H5 CH3 H O OCF2OF2H H OC2H5 CH3 H O SCF2CF2H H OC2H5 CH3 H O CH2OC2H5 H OC2H5 CH3 H O SCH3 H OC2H5 CH3 H O CO2CH2Ch2Cl H OC2H5 CH3 H O CO2CH2CH=CH2 H OC2H5 CH3 H O CO2CH(CH3)2 H OC2H5 CH3 H O OSO2CHFCF2H H OC2H5 CH3 H O OSO2CHFCCl3 H OC2H5 CH3 H O OSO2CHFCH2F H Table 1 (continued) R1 R2 R3 W R7 R8 m.p.( C) OC2H5 CH3 H O OSO2CH2CH2Cl H OC2H5 CH3 H O SO2N(CH3)2 H 169-175 OC2H5 CH3 H O SO2N(CH3)[(CH2)2CH3] H OC2H5 CH3 H O CO2CH2CH(CH3)2 H OC2H5 CH3 H O OCH2CH(CH3)2 H OC2H5 CH3 H O CO2CH3 H 187-189 OC2H5 CH3 CH3 O SO2CH3 H OC2H5 CH3 CH3 O CO2CH3 H OC2H5 CH3 CH3 O OSO2CH(CH3)2 H OC2H5 CH3 CH3 O CF3 H OC2H5 CH3 CH3 O OCF2CF2H H OC2H5 C2H5 CH3 O Cl H OC2H5 C2H5 H O SCHF2 H OC2H5 C2H5 H O SO2(CH2)2CH3 H OC2H5 C2H5 H O CO2C2H5 H OC2H5 CH3 H O OSO2(CH2)3Cl H O(CH)2CH3 CH3 H O Cl H O(CH2)2CH3 CH3 H O C2H5 H OCH(CH3)2 CH3 H O CO2CH(CH3)2 H O(CH2)3CH3 CH3 H O CO2CH3 H OCH2CH=CH2 CH3 H O SO2CH3 H OCH2C(CH3)=CH2 CH3 H O CO2CH3 H OCH2C#CCH3 CH3 H O CO2CH3 H OCH2C#CH CH3 H O CO2C2H5 H CF3 CH3 H O CO2CH3 H CF3 CH3 H O Cl H CF3 C2H5 H O NO2 H CF3 C2H5 H O CH3 H CF2CF3 CH3 H O CO2CH(CH3)2 H CF2CF3 CH3 H O CO2CH3 H N(CH3)2 CH3 H O CO2CH3 H CF3 C2H5 H O CO2CH3 H Table 1 (continued) RÚ Rê R W R7 R8 m.p.( C) CF3 C2H5 H O CF3 H CF3 C2H5 H O CH2OCH3 H SCH3 CH2CH=CH2 H O CO2CH3 H 146-149 SC2H5 CH3 H O CH3 5-CH3 193-195 SC2H5 C2H5 H O CO2CH3 H 150-152 CH(CH3)2 CH3 H O CO2CH3 H 190-197 OCH3 CH3 H H H H OCH3 CH3 H H CH3 H 210-213 OCH3 CH3 H H C2H5 H OCH3 CH3 H H C2H2CH3 H OCH3 CH3 H H CH(CH3)2 H OCH3 CH3 H H (CH2)3CH3 H OCH3 CH3 H H OCH3 H OCH3 CH3 H H OCH2CH3 H OCH3 CH3 H H OCH2CH2CH3 H 154-157 OCH3 CH3 H H OCH(CH3)C2H5 H OCH3 CH3 H H F H OCH3 CH3 H H Cl H 200-205 OCH3 CH3 H H Br H OCH3 CH3 H H NO2 H 185-189 OCH3 CH3 H H CF3 H OCH3 CH3 H H CO2C2H5 H 144-148 OCH3 CH3 H H CO2(CH2)2CH3 H 117-120 OCH3 CH3 H H CO2CH(CH3)2 H 165-169 OCH3 CH3 H H CO2CH(CH3)C2H5 H OCH3 CH3 H H CO2(CH2)5CH3 H OCH3 CH3 H H CO2CH2CH=CH2 H 139-144 OCH3 CH3 H H CO2CH2CH=CHCH3 H OCH3 CH3 H H CO2CH2C#CHCH3 H OCH3 CH3 H O CO2CH2CH2OCH3 H OCH3 CH3 H O CO2CH2CH2Cl H OCH3 CH3 H O CO2CH2CH2OC2H5 H Table I (continued) R1 R2 R3 W R7 R8 m.p. ( C) OCH3 CH3 H O CO2(CH2)3OC2H5 H OCH3 CH3 H O CO2CH2C=CC2H5 H OCH3 CH3 H O CO2CF2CFH2 H OCH3 CH3 H O CO2CH2CH2-F H OCH3 CH3 H O CO2CH2CHFCF2H H OCH3 CH3 H O SO2N(CH3)2 H 183-186 OCH3 CH3 H O SO2N(C2H5)2 H OCH3 CH3 H O SO2N(CH3)C2H5 H OCH3 CH3 H O SO2N(CH3)CH2CH2CH3 H OCH3 CH3 H O SO2N(CHH3)CH3 H OCH3 CH3 H O OSO2CH3 H 174-176 OCH3 CH3 H O OSO2C2H5 H OCH3 CH3 H O OSO2CH2CH2CH3 H OCH3 CH3 H O OSO2CH2CH2OCH3 H OCH3 CH3 H O OSO2CF3 H OCH3 CH3 H O OSO2CH2CH2Cl H OCH3 CH3 H O SOCH3 H OCH3 CH3 H O SCH3 H OCH3 CH3 H O SO2CH3 H 183-190 OCH3 CH3 H O SC2H5 H OCH3 CH3 H O SO2C2H5 H OCH3 CH3 H O SO2CH2CH2CH3 H 174-177 OCH3 CH3 H O SO2CH(CH3)2 H OCH3 CH3 H O SO2(CH2)3CH3 H OCH3 CH3 H O SO2CH2CH=CH2 H OCH3 CH3 H O SO2CF3 H OCH3 CH3 H O SO2CH2CH2Cl H OCH3 CH3 H O SO2CF2CF3 H OCH3 CH3 H O SO2CCl2CF3 H OCH3 CH3 H O N(CH3)SO2CH3 H OCH3 CH3 H O N(CH3)SO2C2H5 H OCH3 CH3 H O N(CH3)SO2(CH2)3CH3 H Table 1 (continued) R1 R2 R3 W R7 R8 m. p. ( C) OCH3 CH3 H O N(CH3)SO2CH2CH2OCH3 H OCH3 CH3 H O N(CH3)SO2CF3 H OCH3 CH3 H O N(CH3)SO2CH2CH2Cl H OCH3 CH3 H O CH2CO2CH3 H OCH3 CH3 H O CH2CO2C2H5 H OCH3 CH3 H O CH2CO2CH(CH3)2 H OCH3 CH3 H O CH2CO2CH2CH2OCH3 H OCH3 CH3 H O CH2CO2CH2CH2Cl H OCH3 CH3 H O CH2CO2CH2CH=CH2 H OCH3 CH3 H O CH(CH3)CO2CH3 H OCH3 CH3 H O CH2SCH3 H OCH3 CH3 H O CH2SOC2H5 H OCH3 CH3 H O CH2SO2CH3 H OCH3 CH3 H O CH2SO2CH2CH=CH2 H OCH3 CH3 H O CH2SO2CF3 H OCH3 CH3 H O CH2SO2CF2CF3 H OCH3 CH3 H O CH2SO2CH2CH2CH3 H OCH3 CH3 H O CH(CH3)SO2CH3 H OCH3 CH3 H O OCH2CH=CH2 H OCH3 CH3 H O OCH2CH=CHCH3 H OCH3 CH3 H O OCH2C#CH H OCH3 CH3 H O CH2CH2OCH3 H OCH3 CH3 H O CH2CH2OC2H5 H OCH3 CH3 H O OCF3 H OCH3 CH3 H O OCF2CF3 H OCH3 CH3 H O OCH2CH2Cl H OCH3 CH3 H O OCH2CF2CF3 H OCH3 CH3 H O OCH2OCH3 H OCH3 CH3 H O OCH2CH2OCH3 H OCH3 CH3 H O OCH2OC2H5 H OCH3 CH3 H O OCH2CH2OC2H5 H OCH3 CH3 H O CH2OCH3 H Table 1 (continued) R1 R2 R3 W R7 R8 m. p. ( C) OCH3 CH3 H O CH2OC2H5 H 154-157 OCH3 CH2CF3 H O CO2CH3 H 150-157 OCH3 CH2CF3 H O SO2N(CH3)2 H 90-100 OCH3 CH3CF3 H O Cl H 195-225 OCH3 CH2CF3 H O SO2CH3 H 158-160 OCH3 CH2CF3 H O NO2 H OC2H5 CH3 H O CH3 H OC2H5 CH3 H O CH2CH3 H OC2H5 CH3 H O CH2(CH3)2 H OC2H5 CH3 H O OCH2CH2CH3 H OC2H5 CH3 H O Cl H 180-183 OC2H5 CH3 H O Br H OC2H5 CH3 H O NO2 H OC2H5 CH3 H O CF3 H OC2H5 CH3 H O CO2(CH2)5CH3 H OC2H5 CH3 H O CO2CH2CH2OCH3 H OC2H5 CH3 H O CO2CH2C#CH H OC2H5 CH3 H O N(CH3)SO2CH3 H OC2H5 CH3 H O N(CH3)SO2C2H5 H OC2H5 CH3 H O OSO2CH3 H OC2H5 CH3 H O SO2CH2CH2CH3 H OC2H5 CH3 H O SO2CH2CH#CH2 H OC2H5 CH3 H O SO2CF3 H OC2H5 CH3 H O CH2CO2CH3 H OC2H5 CH3 H O CH(CH3)CO2CH3 H OC2H5 CH3 H O CH2CO2CH2CH2Cl H OC2H5 CH3 H O CH2SO2CH3 H OC2H5 CH3 H O CH2SCH3 H OC2H5 CH3 H O CH(CH3)SO2CH3 H OC2H5 CH3 H O OCH2CH#CH2 H OC2H5 CH3 H O OCH2C#COH3 H OC2H5 CH3 H O CH2OCH3 H Table 1 (continued) R1 R2 R3 W R7 R8 m. p. ( C) OC2H5 CH3 H O CH2CH2OC2H5 H OC2H5 CH3 H O OCF2CF2CH3 H OC2H5 CH3 H O OCH2OCH3 H OC2H5 CH3 H O OCH2CH2OCH3 H OC2H5 CH3 H O OCH2CH2OCH2CH3 H OC2H5 CH3 H O O(CH2)3OCH3 H Cl CH3 H O CH3 H Cl CH3 H O CH(CH3)2 H Cl CH3 H O OCH3 H Cl CH3 H O OCH2CH2CH3 H Cl CH3 H O Cl H Cl CH3 H O NO2 H Cl CH3 H O CF3 H Cl CH3 H O CO2CH3 H Cl CH3 H O CO2C2H5 H Cl CH3 H O CO2CH2CH=CH H Cl CH3 H O SO2N(CH3)2 H Cl CH3 H O OSO2CH3 H Cl CH3 H O N(CH3)SO2CH3 H Cl CH3 H O SO2CH3 H Cl CH3 H O SO2CH2CH2CH3 H Cl CH3 H O CH2CO2CH3 H Cl CH3 H O CH2SCH3 H Cl CH3 H O CH2SO2CH3 H Cl CH3 H O OCH2CH=CH2 H Cl CH3 H O OCH2C#CCH3 H Cl CH3 H O CH2OCH3 H Cl CH3 H O CH2CH2OCH3 H Cl CH3 H O CH2CH2Cl H NHCH3 CH3 H O CH3 H NHCH3 CH3 H O CH2CH3 H NHCH3 CH3 H O OCH3 H Table 1 (continued) R1 R2 R3 W R7 R8 m. p. ( C) NHCH3 CH3 H O Br H NHCH3 CH3 H O Cl H NHCH3 CH3 H O N02 H NHCH3 CH3 H O CF3 H NHCH3 CH3 H O CO2CH3 H NHCH3 CH3 H O CO2CH(CH3)2 H NHCH3 CH3 H O CO2CH2CH2Cl H NHCH3 CH3 H O SO2N(CH3)2 H NHCH3 CH3 H O SO2N(OCH3)CH3 H NHCH3 CH3 H O OSO2CF3 H NHCH3 CH3 H O SO2CH3 H NHCH3 CH3 H O S02CH2CH2CH3 H NHCH3 CH3 H O SO2CH2CH=CH2 H NHCH3 CH3 H O CH2CO2CH3 H NHCH3 CH3 H O CH2CO2CH2CH2Cl H NHCH3 CH3 H O CH2SOCH3 H NHCH3 CH3 H O CH2SO2CH3 H NHCH3 CH3 H O OCH2CH=CH2 H NHCH3 CH3 H O OCH2C#CH H NHCH3 CH3 H O CH2CH2OC2H5 H NHCH3 CH3 H O OCH2CF2CF5 H NHCH3 CH3 H O OCH20CH3 H NHCH3 CH3 H O OCH2CH2OCH3 H NHCH3 CH3 H O OCH2CH2OC2H5 CH(OCH3)2 OH3 H O CH3 H CH(OCH3)2 CH3 H O CH(CH3)2 H CH(OCH3)2 CH3 H O OCH3 H CH(OCH3)2 CH3 H O OCH2CH2CH3 H CH(OCH3)2 CH3 H O F H CH(OCH3)2 CH3 H O Cl H CH(OCH3)2 CH3 H O Br H CH(OCH3)2 CH3 H O NO2 H Table 1 (continued) EMI72.1 <tb> R1 <SEP> 2 <SEP> 3 <SEP> W <SEP> 7 <SEP> R8 <SEP> m.p.(OC) <tb> OK(0OK3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> OF3 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> 0020K3 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> C02C2 <SEP> 5 <SEP> H <tb> OK(O0K3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH2CH=CH2 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> 5 2 <SEP> ( <SEP> 3 <SEP> 2 <SEP> H <tb> OK(OOK3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> 5 2N(CH3)c2H5 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> 0 <SEP> OS02CF3 <SEP> K <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> S02 <SEP> 3 <SEP> H <tb> OK(OCK3)2 <SEP> CH3 <SEP> H <SEP> 0 <SEP> 502CH2CH2CH3 <SEP> H <tb> OK(OOHS)2 <SEP> CH3 <SEP> H <SEP> O <SEP> SO2CH2CH=CH2 <SEP> H <tb> OK(OOK3)2 <SEP> CH3 <SEP> K <SEP> O <SEP> 0K2C020K3 <SEP> H <tb> OK(0OK3)2 <SEP> CH3 <SEP> K <SEP> O <SEP> CH2C02CH2CH20CH3 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> 0H25020K3 <SEP> H <tb> OK(OCK3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> OCH2CH=CH2 <SEP> H <tb> OK(0C)2 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH2OcH3 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> OK2OCHS <SEP> H <tb> OK(OOK3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> OCH2CH20CH3 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> OCF2CF3 <SEP> H <tb> OH(O0H)2 <SEP> CH3 <SEP> H <SEP> O <SEP> OCH2CF2CF3 <SEP> H <tb> <SEP> ,0 <tb> CHO <SEP> J <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> CK3 <SEP> K <SEP> CH3 <SEP> O <SEP> O <SEP> CH(CH3)2 <SEP> H <tb> <SEP> /01 <tb> OK3 <SEP> j <SEP> CH3 <SEP> H <SEP> O <SEP> OCH2CH3 <SEP> H <tb> CH <SEP> 3 <SEP> CH3 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> <SEP> O <tb> CXHo <SEP> K <SEP> CH3 <SEP> H <SEP> O <SEP> NO2 <SEP> H <tb> Table 1 (continued) EMI73.1 <tb> <SEP> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R7 <SEP> 28 <SEP> m.p.(OC) <tb> <SEP> /0E <tb> <SEP> 0HS <SEP> K <SEP> 0 <SEP> OF3 <SEP> K <tb> <SEP> ,0 <tb> CH0 <SEP> CH3 <SEP> H <SEP> 0 <SEP> C02CH3 <SEP> H <tb> <SEP> 0 <tb> CH <SEP> CH3 <SEP> H <SEP> 0 <SEP> C02CH2CH2C1 <SEP> H <tb> <SEP> \ <SEP> Oi <SEP> L <tb> CHOJ <SEP> CH3 <SEP> H <SEP> 0 <SEP> C02CH(CH3) <SEP> H <tb> CH0 <SEP> OK3 <SEP> K <SEP> O <SEP> S02N(CH3)2 <SEP> H <tb> <SEP> /0E <tb> CHoJ <SEP> 3 <SEP> H <SEP> 0 <SEP> 502N(OCH3)cH3 <SEP> H <tb> <SEP> OK3 <SEP> CH3 <SEP> H <SEP> 0 <SEP> N(OK3)SO2CH3 <SEP> H <tb> <SEP> ,0 <tb> CH0 <SEP> CH3 <SEP> H <SEP> 0 <SEP> OS02CH3 <SEP> H <tb> <SEP> 0 <tb> ·H0 <SEP> OH3 <SEP> H <SEP> 0 <SEP> SO2CH3 <SEP> H <tb> CH <SEP> 3 <SEP> ¯; <SEP> H <SEP> 0 <SEP> S02CH2CH2CH3 <SEP> H <tb> <SEP> C <SEP> H <SEP> 0 <SEP> OK <SEP> CO <SEP> OK <SEP> CH,CO,CH3 <SEP> H <tb> CH <SEP> 3 <SEP> CH3 <tb> CH <SEP> 2 <SEP> CH3 <SEP> H <SEP> 0 <SEP> CH(CH3)C02CH3 <SEP> H <tb> CH <SEP> 7 <tb> /0 <tb> OH <SEP> H <SEP> H <SEP> 0 <SEP> OK2SO2CK3 <SEP> H <tb> C/H03 <SEP> H <SEP> H <SEP> 0 <SEP> CH25C2H5 <SEP> H <tb> Table 1 (continued) EMI74.1 <tb> <SEP> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R7 <SEP> 8 <SEP> m.p.(OC) <tb> <SEP> 8 <tb> <SEP> /OI <tb> OK3 <SEP> - <SEP> CH3 <SEP> H <SEP> O <SEP> OCH2CH=CH2 <SEP> H <tb> " 8 <tb> CHo <SEP> K <SEP> CH3 <SEP> O <SEP> O <SEP> CH20CH3 <SEP> H <tb> <SEP> /0 > s <tb> CH <SEP> J <SEP> CH3 <SEP> H <SEP> O <SEP> CH2COCH3 <SEP> H <tb> <SEP> o <tb> C; <SEP> 2 <SEP> CH3 <SEP> H <SEP> O <SEP> OCH2CH20CH3 <SEP> 9 <tb> Ck <tb> OH3 <SEP> H <SEP> 0 <SEP> 0OF2OF3 <SEP> K <tb> OK3 <SEP> K <SEP> CH3 <SEP> O <SEP> O <SEP> OCH2CF2CF3 <SEP> H <tb> CH <SEP> 3 <SEP> CH3 <SEP> H <SEP> O <SEP> OOH20HCH20OK3 <SEP> H <tb> <SEP> 0 <tb> C\o <SEP> S <SEP> CH3 <SEP> K <SEP> O <SEP> OCC12CF3 <SEP> H <tb> <SEP> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2N(CH3)2 <SEP> H <tb> <SEP> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2N(C2H5)2 <SEP> H <tb> <SEP> OCH3 <SEP> 3 <SEP> H <SEP> 0 <SEP> CO2N(CH3)C2H5 <SEP> H <tb> <SEP> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C02N(CH3)CH2CH2 <SEP> H3 <SEP> H <tb> <SEP> 00K3 <SEP> CH3 <SEP> H <SEP> O <SEP> C02(CH3)C6H5 <SEP> H <tb> <SEP> OCH3 <SEP> OH3 <SEP> H <SEP> O <SEP> C02N(CH2)4 <SEP> H <tb> <SEP> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C(O)SCH3 <SEP> H <tb> <SEP> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C(O)SC2H5 <SEP> H <tb> <SEP> OCH3 <SEP> OK3 <SEP> H <SEP> O <SEP> C(O)SCH2CH2CH3 <SEP> H <tb> <SEP> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C(O)SCH(CH3)2 <SEP> H <tb> <SEP> OC2H5 <SEP> 3 <SEP> H <SEP> O <SEP> CO2N <SEP> (OK3)2 <SEP> H <tb> <SEP> OC2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> C02N(C2H5)2 <SEP> H <tb> <SEP> OC2H5 <SEP> OK3 <SEP> H <SEP> O <SEP> C02N(CH3)C2H5 <SEP> H <tb> Table 1 (continued) R1 R2 R3 W R7 R8 m. p. ( C) OC2H5 CH3 H O CO2N(CH3)CH2CH2CH3 H OC2H5 CH3 H O C02(CH3)C6H5 H OC2H5 CH3 H O CO2N(CH2)4 H OC2H5 CH3 H O C(O)SCH3 H OC2H5 CH3 H O C(O)SC2H5 H OC2H5 CH3 H O C(O)SCH2CH2CH3 H OC2H5 CH3 H O C(O)SCH(CH3)2 H SCH3 CH3 H O C02N(CH3)2 H SCH3 CH3 H O C02N(C2H5)2 H SCH3 CH3 H O CO2N(CH3)C2H5 H SCH3 CH3 H O CO2N(CH3)CH2CH2CH3 H SCH3 CH3 H O CO2(CH3)C6H5 H SCH3 CH3 H O CO2N(CH2)4 H SCH3 CH3 H O C(O)SCH3 H SCH3 CH3 H O C(O)SC2H5 H SCH3 CH3 H O C(O)SCH2CH2CH3 H SCH3 CH3 H O C(O)SCH(CH3)2 H Table 2 EMI76.1 R1 R2 R3 W R16 R17 m. p. ( C) H C2H5 H O CO2CH3 H H n-C3H7 H O Cl H CH3 CH2CH(CH3)2 H O CO2CH3 H CH3 C2H5 H O Cl H CH3 C2H5 H O H H CH3 C2H5 H O Cl H CH3 C2H5 H O CO2CH(CH3)C2H5 H CH3 C2H5 CH3 O CO2CH3 H C2H5 CH3 H O CO2(CH2)3CH3 H C2H5 CH3 CH3 O Cl H C2H5 CH3 H O Cl H C2H5 CH3 H O CO2CH2CH2OCH3 H C2H5 C2H5 H O CO2CH2CH(CH3)2 H n-C4H9 CH3 H O CO2CH3 H CH(CH3)2 CH3 H O NO2 H n-C3H7 CH3 H O CF3 H CH3 n-C3H7 H O CO2CH3 H CH3 CH2CH=CH2 H O Cl H CH3 CH2C(CH3)=CH2 H O OCH3 H CH2CH=CH2 CH3 H O C2H5 H CH2C(CH3)=CH2 CH3 H O SO2CH3 H CH3 CH3#CCH3 H O SO2CH3 H CH2C#C-CH3 CH3 H O SO2O2H5 H C2H5 CH3 H O SO2N(CH3)2 H C2H5 CH3 H O SO2N(CH3)OCH3 H Table 2 (continued) R1 R2 R3 W R16 R17 m. p. ( C) CH3 C2H5 H O SCH3 H C2H5 CH3 H O S(CH2)3CH3 H C2H5 CH3 H O F H C2H5 CH3 H S CH3 H C2H5 CH3 CH3 O SO2CH3 H C2H5 C2H5 H O n-C4H9 H CH3 CH2C=CH H O Cl H SCH3 CH3 H O CH3 H SCH3 CH3 H O H H SCH3 CH3 H O Cl H SCH3 CH3 H O NO2 H SCH3 CH3 H S Cl H SCH3 CH3 CH3 O Cl H SCH3 CH3 H O Cl 5-F SCH3 CH3 H O SO2CH3 4-Br SCH3 C2H5 H O SO2CH3 6-Br SCH3 CH3 H O SO2N(CH3)2 6-Cl CH3 C2H5 H O NO2 5-F C2H5 CH3 H O CH3 4-Cl SCH3 CH3 CH3 O Cl 6-Cl SCH3 C2H5 H S OCH3 H SCH3 CH3 H O CO2CH2CH=CH2 H SCH3 CH3 H O CO2CH(CH3)2 H SCH3 C2H5 H O CO2CH2CH2Cl H SCH3 CH3 H O CO2CH2CH(CH3)2 H SCH3 C2H5 H O n-C4H9 H SCH3 CH3 H O SCH3 H SCH3 CH3 H O S(CH2)2CH3 H SCH3 CH3 H O F H SC2H5 CH3 H S CH3 H SC2H5 CH3 H O SO2CH3 H Table 2 (continued) R1 R2 R3 W R16 R17 m. p. ( C) S(CH2)2CH3 CH3 H O SO2CH3 H SCH(CH3)C2H5 CH3 H O Cl H SCH(CH3)2 CH3 H O S02C2H5 H SCH2C#C-CH2 CH3 H O CO2C2H5 H SCH2C(CH3)=CH2 CH3 H O SO2CH3 H SCH2C#C-CH3 CH3 H O C02CH3 H SCH3C#CH CH3 H O Cl H SCH2CO2CH3 CH3 H O CF3 H SCH2CO2CH(CH3)2 CH3 H O NO2 H SCH(CH3)CO2CH3 CH3 H O CO2CH3 H OCH3 C2H5 H S Cl H OCH3 C2H5 CH3 O Cl H OCH3 C2H5 H O H H OCH3 O2Ks H O F H OCH3 C2H5 H O H 4-F OCH3 C2H5 H O H 5-F OCH3 C2H5 H O Cl H OCH3 C2H5 H O SO2CH3 H OCH3 C2H5 H O CF3 H OCH3 C2H5 H O NO2 H OC2H5 CH3 H S CH3 H OC2H5 CH3 H O OC2H5 H OC2H5 CH3 H O Cl H OC2H5 CH3 H O SO2CH3 H OC2H5 CH3 H O SO2CH3 H OC2H5 CH3 H O SO2N(CH3)[(CH2)2CH3] H OCH3 CH3 H O SO2N(CH3)2 H OCH3 CH3 H O SO2N(CH3)OCH3 H OCH3 CH3 H O SO2C2H5 H OC2H5 CH3 H O SO2(CH2)3CH3 H Table 2 (continued) R1 R2 R3 W R16 R17 m. p. ( C) OC2H5 CH3 H O Cl 6-CH3 OCH3 C2H5 H O NO2 5-C1 OCH3 C2H5 H O Cl 5-CH3 OCH3 C2H5 H O Br 4-Cl OCH3 C2H5 H O OCH3 5-F OCH3 C2H5 H O SO2CH3 4-Br OCH3 C2H5 H O SO2CH3 6-Cl OC2H5 CH3 H O SO2CH3 5-OCH3 OCH3 C2H5 H O SO2CH3 4-OCH3 OCH3 C2H5 H O SCH3 H OC2H5 CH3 H O S(CH2)3CH3 H OC2H5 CH3 H O SO2N(CH3)C2H5 H OC2H5 CH3 H O CF3 H OCH3 C2H5 H O Br H OCH3 C2H5 H O NO2 H OCH3 C2H5 H O n-C3H7 H OC2H5 CH3 H O OCH2(CH2)2CH3 H OC2H5 CH3 H O OCH2CH(CH3)2 H OC2H5 CH3 H O OC2H5 H OCH3 CH3 H O CO2CH2CH2OCH3 H OCH3 C2H5 H O CO2(CH2)3OCH3 H OCH3 C2H5 H O CO2(CH2)2OCH3 H OC2H5 C2H5 H O CO2CH2CH2Cl H OCH3 C2H5 CH3 O CO2C2H5 H OCH3 C2H5 CH3 O CO2CH3 H OC2H5 C2H5 CH3 O SO2N(C2H5)2 H OCH2CH=CH2 CH3 H O SO2CH3 H OCH2C(CH3)=CH2 CH3 H O Cl H OCH(CH3)C2H5 CH3 H O SO2CH3 H O(CH2)2CH3 CH3 H O SO2CH3 H OCH(CH3)2 CH3 H O CO2C2H5 H Table 2 (continued) R1 R2 R3 W R16 R17 m.p.( C) O(CH2)2CH3 CH3 H O CO2CH(CH3)2 H OCH2CH=CHCH3 CH3 H O Cl H OCH2#CCH3 CH3 H O 502CH3 H CH2OCH3 CH3 H O NO2 H CH2OCH3 CH3 H O SO2N(CH3)[CH(CH3)2] H CH2OCH3 CH3 H O SO2N(CH3)2 H CH2OCH3 CH3 H O SO2CH3 H CH20CH3 CH3 H O Cl H CH2OCH3 CH3 H O F H CH2OCH3 CH3 H O H H CH2OCH3 CH3 H S Cl H CH2OCH3 CH3 CH3 O CH3 H CH2OCH3 CH3 CH3 O Cl H CH2OCH3 CH3 H O SC2H5 H CH2OCH3 CH3 H O OCH3 H CH2OCH3 CH3 H O C02CH2CH2C1 H CH2OC2H5 CH3 CH3 O CO2CH(CH3)2 H CH20C2H5 CH3 H O CO2CH2CH=CH2 H CH2O(CH2)3CH3 CH3 H O CO2CH3 CH2CH(CH3)2 CH3 H O Cl CH2CH2OCH3 CH3 H O CO2C2H5 CH2CH2OCH(CH3)2 CH3 H O O2HC(CH3)2 CH2CH2O(CH2)2CH3 CH3 H O SO2CH3 N(CH3)2 CH3 H O Cl CF2CF3 CH3 H O SO2CH3 CF3 CH3 H O Cl CF2CF3 CH3 H O CO2CH3 CF2CF3 CH3 H O NO2 CF2CF3 CH3 H O SO2CH(CH3)2 CH3 CH2OCH3 H S Cl Table 2 (continued) R1 R2 R3 W R16 R17 m.p.( C) CH3 CH2OCH3 H O CO2CH3 H CH3 CH2CH2OCH3 H O Cl H CH3 CH2SCH3 H O CO2CH3 H CH3 CH2CH2SCH3 H O SO2C2H5 H SCH3 CH3 CH3 O SO2N(CH3)2 H SCH3 CH3 H O SO2(CH2)3CH3 H SCH3 CH3 H O S(CH2)3CH3 H SCH3 CH3 H O SO2CH2CH(CH3)2 H SCH3 CH3 H O SCH(CH3)2 H OC2H5 CH3 H O NO2 4-F SCH3 CH3 H O NO2 4-OCH3 SCH3 CH3 CH3 O O2CH2CH2OCH3 H SCH3 CH3 H O O-CH(CH3)C2H5 H SCH3 CH3 CH3 O O-H(CH3)C2H5 H OC2H5 C2H5 H O F H CF3 C2H5 CH3 O SO2CH3 H SCH3 CH3 CH3 O SO2N(OCH3)CH3 H OCH3 CH3 H O CH3 H OCH3 CH3 H O CH(CH3)2 H OCH3 CH3 H O OCH3 H OCH3 CH3 H O O(CH2)3CH3 H OCH3 CH3 H O F H OCH3 CH3 H O Cl H OCH3 CH3 H O Br H OCH3 CH3 H O CF3 H OCH3 CH3 H O CO2CH3 H OCH3 CH3 H O CO2C2H5 H OCH3 CH3 H O CO2CH(CH3)2 H OCH3 CH3 H O CO2CH2CH2CH2CH3 H OCH3 CH3 H O CO2CH2CH2Cl H OCH3 CH3 H O CO2CH2CH=CH2 H OCH3 CH3 H O SO2N(CH3)2 H Table 2 (continued) R1 R2 R3 W R16 R17 m.p. ( C) OCH3 CH3 H O SO2N(CH3)C2H5 H OCH3 CH3 H O SO2N(C2H5)2 H OCH3 CH3 H O SO2N(OCH3)CH3 H OCH3 CH3 H O SO2CH3 H OCH3 CH3 H O SOCH3 H OCH3 CH3 H O SCH3 H OCH3 CH3 H O SC2H5 H OCH3 CH3 H O SO2C2H5 H OCH3 CH3 H O SO2CH2CH2CH3 H OCH3 CH3 H O SO2CH(CH3)2 H OCH3 CH3 H O SO2H2CH=CH2 H OCH3 CH3 H O SH2CH=CH2 H OCH3 CH3 H O SO2CF3 H OCH3 CH3 H O SO2CF2CF3 H OC2H5 CH3 H O Cl H OC2H5 CH3 H O Br H OC2H5 CH3 H O SO2CH3 H OC2H5 CH3 H O CO2CH3 H OC2H5 CH3 H O CO2C2H5 H OC2H5 CH3 H O CO2CH2CH=CH2 H OC2H5 CH3 H O SO2N(CH3)2 H OC2H5 CH3 H O CH3 H OC2H5 CH3 H O CH(CH3)2 H OC2H5 CH3 H O CO2CH(CH3)2 H OCH3 CH2CF3 H O Cl H OCH3 CH2CF3 H O SO2CH3 H OCH3 CH2CF3 H O SO2N(CH3)2 H OCH3 CH2CF3 H O CO2CH3 H OCH3 CH2CF3 H O Br H Cl CH3 H O Cl H Cl CH3 H O Br H Cl CH3 H O CH3 H Table 2 (continued) EMI83.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R16 <SEP> 17 <SEP> m.P.( C) <tb> <SEP> L <SEP> +7 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> OCH3 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> CF3 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> CO2CH2CH=CH2 <SEP> H <tb> C1 <SEP> C <SEP> - <SEP> H <SEP> O <SEP> 502N(CH3)2 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> 0 <SEP> S02CH, <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CO2CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> S 2CW3 <SEP> H <tb> CH( CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> CH( CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2 <SEP> 5 <SEP> H <tb> OK(0CH)2 <SEP> CH3 <SEP> H <SEP> O <SEP> SOZN(C)2 <SEP> H <tb> <SEP> /0n <tb> CH <SEP> j <SEP> CH3 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> <SEP> 0 <tb> O\K0 <SEP> j <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <SEP> H <tb> <SEP> /0 > <tb> OK3 <SEP> K <SEP> CH3 <SEP> O <SEP> <SEP> C02CH2CH=CH2 <SEP> H <tb> <SEP> /01 <tb> CHO <SEP> j <SEP> CH3 <SEP> H <SEP> O <SEP> SO2CH2CH=CH2 <SEP> H <tb> Table 3 EMI84.1 R1 R2 R3 W R16 R17 m.p. ( C) H C2H5 H O CO2CH3 H H n-C3H7 H O Cl H CH3 2H2CH(CH3)2 H O CO2CH3 H CH3 C2H5 H O Cl H CH3 C2H5 H O H H CH3 C2H5 H S Cl H CH3 C2H5 H O CO2CH(CH3)C2H5 H CH3 C2H5 CH3 O CO2CH3 H C2H5 CH3 H O CO2(CH2)3CH3 H C2H5 CH3 CH3 O Cl H C2H5 CH3 H S Cl H C2H5 CH3 H O CO2CH2CH2OCH3 H C2H5 C2H5 H O CO2CH2CH(CH3)2 H n-C4H9 CH3 H O CO2CH3 H CH(CH3)2 CH3 H O NO2 H n-C3H7 CH3 H O CF3 H CH3 n-C3H7 H O CO2CH3 H CH3 CH2CH=CH2 H O Cl H CH3 CH2C(CH3)=CH2 H O OCH3 H CH2CH=CH2 CH3 H O C2H5 H CH2C(CH3)=CH2 CH3 H O SO2CH3 H CH3 CH2C#CCH3 H O SO2CH3 H CH2C#C-CH3 CH3 H O SO2C2H5 H C2H5 CH3 H O SO2N(CH3)2 H C2H5 CH3 H O SO2N(CH3)OCH3 H Table 3 (continued) R1 R2 R3 W R16 R17 m.p. ( C) CH3 C2H5 H O SCH3 H C2H5 CH3 H O S(CH2)3CH3 H C2H5 CH3 H O F H C2H5 CH3 H S CH3 H C2H5 CH3 CH3 O SO2CH3 H C2H5 C2H5 H O n-C4H9 H CH3 CH2C#CH H O Cl H SCH3 CH3 H O CH3 H SCH3 CH3 H O H H SCH3 CH3 H O Cl H SCH3 CH3 H O NO2 H SCH3 CH3 H S Cl H SCH3 CH3 CH3 O Cl H SCH3 CH3 H O Cl 5-F SCH3 CH3 H O SO2CH3 4-Br SCH3 C2H5 H O SO2CH3 6-Br SCH3 CH3 H O SO2N(CH3)2 6-Cl CH3 C2H5 H O NO2 5-F C2H5 CH3 H O CH3 4-Cl SCH3 CH3 CH3 O Cl 6-Cl SCH3 C2H5 H O OCH3 H SCH3 CH3 H O CO2CH2CH=CH2 H SCH3 CH3 H O CO2CH(CH3)2 H SCH3 C2H5 H O CO2CH2CH2Cl H SCH3 CH3 H O CO2CH2CH(CH3)2 H SCH3 C2H5 H O n-C4H9 H SCH3 CH3 H O SCH3 H SCH3 CH3 H O S(CH2)2CH3 H SCH3 CH3 H O F SC2H5 CH3 H S CH3 H SC2H5 CH3 H O SO2CH3 H Table 3 (continued) R1 R2 R3 W R16 R17 m.p. ( C) S(CH2)2CH3 CH3 H O SO2CH3 H SCH(CH3)C2H5 CH3 H O Cl H SH(CH3)2 CH3 H O SO2C2H5 H SCH2CH=CH2 CH3 H O C02C2H5 H SCH2C(CH3)=CH2 CH3 H O SO2CH3 H SCH2C#C-CH3 CH3 H O CO2CH3 H SCH2C#CH CH3 H O Cl H SCH2CO2CH3 CH3 H O CF3 H SCH2COCH(CH3)2 CH3 H O NO2 H SCH(CH3)CO2CH3 CH3 H O CO2CH3 H OCH3 C2H5 H S Cl H OCH3 C2H5 CH3 O Cl H OCH3 C2H5 H O K H OCH3 C2H5 H O F H OCH3 C2H5 H O H 4-F OCH3 C2H5 H O H 5-F OCH3 C2H5 H O Cl H OCH3 C2H5 H O SO2CH3 H OCH3 C2H5 H O CF3 H OCH3 C2H5 H O NO2 H OC2H5 CH3 H S CH3 H OC2H5 CH3 H O OC2H5 H OC2H5 CH3 CH3 O Cl H OC2H5 CH3 CH3 O SO2CH3 H OC2H5 CH3 H S SO2CH3 H OC2H5 CH3 H O SO2N(CH3)[(CH2)2CH3] H OCH3 C2H5 H O SO2N(CH3)2 H OCH3 C2H5 H O SO2N(CH3)OCH3 H OCH3 C2H5 H O SO2C2H5 H OC2H5 CH3 H O SO(CH2)3CH3 H Table 3 (continued) R1 R2 R3 W R16 R17 m.p. ( C) OC2H5 CH3 H O Cl 6-CH3 OCH3 C2H5 H O NO2 5-Cl OCH3 C2H5 H O Cl 5-CH3 OCH3 C2H5 H O Br 4-Cl OCH3 C2H5 H O OCH3 5-F OCH3 C2H5 H O SO2CH3 4-Br OCH3 C2H5 H O SO2CH3 6-Cl OC2H5 CH3 H O SO2CH3 5-OCH3 OCH3 C2H5 H O SO2CH3 4-OCH3 OCH3 C2H5 H O SCH3 H OC2H5 CH3 H O S(CH2)3CH3 H OC2H5 CH3 H O SO2N(CH3)C2H5 H OC2H5 CH3 H O CF3 H OCH3 C2H5 H O Br H OCH3 C2H5 H O NO2 H OCH3 C2H5 H O n-C3H7 H OC2H5 CH3 H O OCH2(CH2)2CH3 H OC2H5 CH3 H O OCH2CH(CH3)2 H OC2H5 CH3 H O OC2H5 H OCH3 C2H5 H O CO2CH2CH2OCH3 H OCH3 C2H5 H O CO2(CH2)3OCH3 H OCH3 C2H5 H O CO2(CH2)2OCH3 H OC2H5 C2H5 H O CO2CH2CH2Cl H OCH3 C2H5 CH3 O CO2C2H5 H OCH3 C2H5 CH3 O CO2CH3 H OC2H5 C2H5 CH3 O SO2N(C2H5)2 H OCH2CH=CH2 CH3 H O SO2CH3 H OCH2C(CH3)=CH2 CH3 H O Cl H OCH(CH3)C2H5 CH3 H O SO2CH3 H O(CH2)2CH3 CH3 H O SO2CH3 H OCH(CH3)2 CH3 H O CO2C2H5 H Table 3 (continued) R1 R2 R3 W R16 R17 m.p. ( C) O(CH2)2CH3 CH3 H O CO2CH(CH3)2 H OCH2CH=CHCH3 CH3 H O Cl H OCH2C=CCH3 CH3 H O SO2CH3 H CH2OCH3 CH3 H O N02 H CH2OCH3 CH3 H O SO2N(CH3)[CH(CH3)2] H CH2OCH3 CH3 H O SO2N(CH3)2 H CH2OCH3 CH3 H O SO2CH3 H CH2OCH3 CH3 H O Cl H CH2OCH3 CH3 H O F H CH2OCH3 CH3 H O H H CH2OCH3 CH3 H S Cl H CH2OCH3 CH3 CH3 O CH3 H CH2OCH3 CH3 CH3 O Cl H CH2OCH3 CH3 H O SC2H5 H CH2OCH3 CH3 H O OCH3 H CH20CH3 CH3 H O CO2H2CH2Cl H CH20C2H5 CH3 CH3 O CO2CH(CH3)2 H CH2OC2H5 CH3 H O CO2CH2CH=CH2 H CH2O(CH2)3CH3 CH3 H O CO2CH3 H CH2CH(CH3)2 CH3 H O Cl H CH2CH2OCH3 CH3 H O CO2C2H5 H CH2CH2OCH(CH3)2 CH3 H O CO2CH(CH3)2 H CH2CH2O(CH2)2CH3 CH3 H O SO2CH3 H N(CH3)2 CH3 H O Cl H CF2CF3 CH3 H O SO2CH3 H CF3 CH3 H O Cl H CF2CF3 CH3 H O CO2CH3 H CF2CF3 CH3 H 3 NO2 CF2CF3 CH3 H O SC2CH(CH3)2 CH3 CH2OCH3 H S Cl CH3 CH2OCH3 H O SO2C2H5 Table 3 (continued) R1 R2 R3 W R16 R17 m.p. ( C) CH3 CH2OCH3 H O CO2CH3 H CH3 CH2CH2OCH3 H O Cl H CH3 CH2SCH3 H O CO2CH3 H CH3 CH2CH2SCH3 H O SO2C2H5 H SCH3 CH3 CH3 O SO2N(CH3)2 H SCH3 CH3 H O SO2(CH2)3CH3 H SCH3 CH3 H O S(CH2)3CH3 H SCH3 CH3 H O SO2CH2CH(CH3)2 H SCH3 CH3 H O SCH(CH3)2 H OC2H5 CH3 H O NO2 4-F SCH3 CH3 H O NO2 4-OCH3 SCH3 CH3 CH3 O CO2CH2CH2OCH3 H SCH3 CH3 H O O-CH(CH3)C2H5 H SCH3 CH3 CH3 O SO2(CH2)CH3 H OC2H5 C2H5 H O F H CF3 C2H5 CH3 O SO2CH3 H SCH3 CH3 CH3 O SO2N(OCH3)CH3 H OCH3 CH3 H O CH3 H OCH3 CH3 H O CH(CH3)2 H OCH3 CH3 H O OCH3 H OCH3 CH3 H O O(CH2)3CH3 H OCH3 CH3 H O F H OCH3 CH3 H O Cl H 165-168 OCH3 CH3 H O Br H OCH3 CH3 H O CF3 H OCH3 CH3 H O CO2CH3 H OCH3 CH3 H O CO2C2H5 H OCH3 CH3 H O CO2CH(CH3)2 H OCH3 CH3 H O CO2CH2CH2CH2CH3 H OCH3 CH3 H O CO2CH2CH2Cl H OCH3 CH3 H O CO2CH2CH=CH2 H OCH3 CH3 H O SO2N(CH3)2 H Table 3 (continued) R1 R2 R3 W R16 R17 m.p. ( C) OCH3 CH3 H O SO2N(CH3)C2H5 H OCH3 CH3 H O SO2(C2H5)2 H OCH3 CH3 H O SO2N(OCH3)CH3 H OCH3 CH3 H O SO2CH3 H OCH3 CH3 H O SOCH3 H OCH3 CH3 H O SCH3 H OCH3 CH3 H O SC2H5 H OCH3 CH3 H O SO2C2H5 H OCH3 CH3 H O SO2CH2CH2CH3 H OCH3 CH3 H O SO2CH(CH3)2 H OCH3 CH3 H O SO2CH2CH=CH2 H OCH3 CH3 H O SCH2CH=CH2 H OCH3 CH3 H O SO2CF3 H OCH3 CH3 H O SO2CF2CF3 H OC2H5 CH3 H O Cl H OC2H5 CH3 H O Br H OC2H5 CH3 H O SO2CH3 H OC2H5 CH3 H O CO2CH3 H OC2H5 CH3 H O CO2C2H5 H OC2H5 CH3 H O CO2CH2CH=CH2 H OC2H5 CH3 H O SO2N(CH3)2 H OC2H5 CH3 H O CH3 H OC2H5 CH3 H O CH(CH3)2 H OC2H5 CH3 H O CO2CH(CH3)2 H OCH3 CH2CF3 H O Cl H OCH3 CH2CF3 H O SO2CH3 H OCH3 CH2CF3 H O SO2N(CH3)2 H OCH3 CH2CF3 H O CO2CH3 H OCH3 CH2CF3 H O Br H Cl CH3 H O Cl H Cl CH3 H O Br H Cl CH3 H O CH3 H Table 3 (continued) EMI91.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R16 <SEP> R17 <SEP> m.p.( C) <tb> <SEP> 3 <SEP> L <tb> Cl <SEP> CH3 <SEP> H <SEP> o <SEP> OCH3 <SEP> H <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> CF3 <SEP> H <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> CO.=H3 <SEP> H <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH2CH=CH2 <SEP> H <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> 502N(CK3)2 <SEP> H <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> SO2CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> o <SEP> Cl <SEP> H <tb> NHCH; <SEP> CH3 <SEP> H <SEP> O <SEP> 2CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> 5 2CH3 <SEP> H <tb> CH(0CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> Cl <SEP> H <tb> CH( CH3)2 <SEP> CH3 <SEP> H <SEP> o <SEP> 002OH3 <SEP> H <tb> CH(OC)2 <SEP> CH3 <SEP> H <SEP> o <SEP> 502N(C <SEP> 3)2 <SEP> H <tb> <SEP> 0 <tb> CH <SEP> l <SEP> CH3 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> <SEP> XOS <tb> <SEP> /0E <tb> CXH <SEP> J <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <SEP> H <tb> CXHo <SEP> j <SEP> C <SEP> 3 <SEP> H <SEP> 2 <SEP> O <SEP> 0020H20H=0H2 <SEP> 2 <SEP> HH <tb> <SEP> /0n <tb> Ct <SEP> g <SEP> CH3 <SEP> H <SEP> O <SEP> 502CH2cH=cH2 <SEP> H <tb> Table 4 EMI92.1 R1 R2 R3 W R17 R18 m.p.( C) H C2H5 H O H CO2CH3 H n-C3H7 H O H CO2C2H5 CH3 C2H5 H O H Br CH3 C2H5 H O H CO2CH(CH3)2 CH3 CH2CH(CH3)2 H O H CO2CH3 CH3 C2H5 H O H NO2 CH3 C2H5 H O H H CH3 C2H5 H S H Cl CH3 C2H5 H O H Cl CH3 C2H5 CH3 O H CO2CH2CH=CH2 CH3 C2H5 H O H CO2CH2CH2Cl CH3 C2H5 CH3 O H CO2CH3 CH3 C2H5 CH3 O H SO2CH3 C2H5 CH3 CH3 O H SO2CH3 C2H5 CH3 CH3 O H OCH3 CH3 C2H5 CH3 O H SO2N(CH3)2 CH3 C2H5 H S H NO2 CH3 C2H5 H O H SO2N(CH3)OCH3 C2H5 CH3 H S H SO2CH3 C2H5 CH3 H O 5-F SO2CH3 C2H5 CH3 H O 4-F Br CH3 C2H5 H O 5-Cl Br CH3 C2H5 H O 5-CH3 Cl C2H5 C2H5 H O H Br C2H5 C2H5 H O H CO2CH3 Table 4 (continued) R1 R2 R3 W R17 R18 m.p. ( C) C2H5 C2H5 H O H SO2CH3 C2H5 C2H5 H O H SO2N(CH3)C2H5 CH3 C2H5 H O H SO2(CH2)2CH3 C2H5 CH3 H O H SCH3 C2H5 C2H5 CH3 O H SO2CH3 C2H5 C2H5 CH3 O H CO2CH3 C2H5 C2H5 H O H H CH3 C2H5 H O 5-F H CH3 C2H5 H O 5-Cl H C2H5 C2H5 H O H SO2N(CH3)2 C2H5 C2H5 H O H Br CH3 C2H5 H O H F C2H5 C2H5 H O H F n-C3H7 CH3 H O H CO2CH3 CH(CH3)2 CH3 H O H SO2CH3 CH2CH(CH3)2 CH3 H O H CO2C2H5 CH3 n-C3H7 H O H Br CH3 CH2CH=CH2 H O H CO2CH(CH3)2 CH3 CH2C(CH3)=CH2 H O H CO2CH3 CH2CH=CH2 CH3 H O H C2H5 CH2C(CH3)=CH2 CH3 H O H SO2CH3 CH3 CH2C#CCH3 H O H CO2CH3 CH2C#CCH3 CH3 H O H SO2C2H5 SCH3 CH3 H S H Br SCH3 CH3 CH3 O H Br SCH3 CH3 H O 4-Cl Br SCH3 CH3 H O 5-OCH3 H SCH3 CH3 H O 5-Cl Cl SCH3 CH3 H O H NO2 SCH3 CH3 H O H SO2N(CH3)C2H5 SCH3 CH3 H O H SO2N(CH3)[CH(CH3)2] Table 4 (continued) R1 R2 R3 W R17 R18 m.p.( C) SCH3 CH3 H O H F SCH3 CH3 H O 5-F H SCH3 CH3 H O 4-Br H SCH3 CH3 H O 5-Br H SCH3 CH3 CH3 O H SO2CH3 SCH3 CH3 H O H CO2CH3 200-202 SCH3 CH3 CH3 O H SO2N(CH3)2 SCH3 CH3 H O H OC2H5 SCH3 CH3 H S H H SCH3 CH3 H O H CO2(CH2)3CH3 SCH3 CH3 H O H CO2CH2CH2OCH3 SCH3 CH3 H O 5-Cl H SCH3 CH3 H O H OCH(CH3)C2H5 SCH3 CH3 H O 5-CH3 CH3 SCH3 CH3 H O H SCH3 SCH3 CH3 H O H S(CH2)3CH3 SCH3 C2H5 H O H SO2C2H5 SCH3 CH3 H O H C02CH(CH3)2 SCH3 CH3 H O H CO2CH2CH=CH2 SCH3 C2H5 H O H CO2CH3 SCH3 C2H5 H O H Br SCH3 C2H5 H O H SO2CH3 SCH3 C2H5 H S H Cl SCH3 C2H5 H O H NO2 SC2H5 CH3 H O H CO2CH(CH3)2 SCH3 CH3 H O H CH3 SCH3 CH3 H O H CO2CH3 SCH3 CH3 H O H SO2CH3 SCH3 CH3 H O H Br SCH3 CH3 CH3 O H Cl SCH3 CH3 H O H Br Table 4 (continued) R1 R2 R3 W R17 R18 m.p.( C) SCH(CH3)2 CH3 H O H CO2CH3 S(CH2)3CH3 CH3 H O H SO2CH3 SCH2CH=CH2 CH3 H O H CO2CH3 S(CH2)2CH3 CH3 H O H CO2CH3 SCH2C(CH3)=CH2 CH3 H O H CO2C2H5 SCH2C#CCH3 CH3 H O H CO2CH3 SCH2CO2CH3 CH3 H O H NO2 SCH2CO2(CH2)3CH3 CH3 H O H CO2CH3 SCH(CH3)CO2CH3 CH3 H O H CO2CH3 OCH3 CH3 H O H CO2CH3 183-186 OCH3 CH3 H O H SO2N(CH3)C2H5 OCH3 CH3 H O H Br OCH3 CH3 H O H Cl OCH3 CH3 H O H NO2 OCH3 CH3 H S H SO2CH3 OCH3 CH3 CH3 O H SO2CH3 OCH3 CH3 H O H SO2CH3 OCH3 CH3 H O H SO2(CH2)2CH3 OCH3 CH3 H O H OCH3 OC2H5 CH3 H O H O(CH2)3CH3 OC2H5 CH3 H O H CO2CH2CH=CH2 OCH3 CH3 H O H CO2CH2CHCl OCH3 CH3 H O H CO2CH(CH3)2 OCH3 CH3 H O H CO2(CH2)2CH3 OC2H5 CH3 H O H Co2(CH2)2CH3 OCH3 CH3 CH3 O H CO2C2H5 OCH3 CH3 H S H Cl OC2H5 CH3 H S H Br OCH3 CH3 H O H SO2CH3 OCH3 CH3 H O H SO2(CH2)3CH3 Table 4 (continued) R1 R2 R3 W R17 R18 m.p.( C) OCH3 C2H5 H O H SO2CH2CH(CH3)2 OCH3 C2H5 CH3 O H SO2CH3 OCH3 C2H5 CH3 O 5-Cl SO2CH3 OCH3 C2H5 CH3 O 5-Br SO2CH3 OCH3 C2H5 H O H OC2H5 OCH3 C2H5 H O H F OCH3 C2H5 H O 5-F F OCH3 C2H5 H O H SC2H5 OC2H5 CH3 H O H SO2N(OCH3)CH3 OC2H5 CH3 H O H SO2N(CH3)[(CH2)2CH3] OC2H5 CH3 H O H H OC2H5 CH3 H O H NO2 OC2H5 CH3 H O H CO2CH(CH3)2 OC2H5 CH3 H O H CO2CH2CH2Cl OC2H5 CH3 H O H CH3 OC2H5 CH3 H O H CH(CH3)2 OC2H5 CH3 H O H CH2CH(CH3)2 OC2H5 CH3 CH3 O H CH3 OC2H5 CH3 CH3 O H SO2CH3 OC2H5 CH3 CH3 O H Cl OC2H5 CH3 H O H C2H5 OC2H5 CH3 H O H NO2 OC2H5 CH3 H O 4-Br Br OC2H5 CH3 H O 4-Cl Cl OC2H5 C2H5 H O H Cl OC2H5 C2H5 H O H CO2CH3 OC2H5 C2H5 H O H SO2CH3 OC2H5 C2H5 H O H SO2N(CH3)2 OC2H5 C2H5 H O H NO2 OC2H5 C2H5 H O H Br OC2H5 C2H5 H O H CO2CH(CH3)2 Table 4 (continued) R1 R2 R3 W R17 R18 m.p.( C) OCH3 C2H5 H O H SO2C2H5 OCH3 C2H5 H O 4-F F OC2H5 CH3 H O H OCH(CH3)2 OCH2CH=CH2 CH3 H O H SO2CH3 OCH2C(CH3)=CH2 CH3 H O H CO2CH3 OCH(CH3)C2H5 CH3 H O H CO2CH3 OCH(CH3)2 CH3 H O H CO2C2H5 O(CH2)2CH3 CH3 H O H Cl OCH2C=CCH3 CH3 H O H NO2 CH2OCH3 CH3 H O H Br CH2OCH3 CH3 H O H Cl CH2OCH3 CH3 CH3 O H SO2CH3 CH2OCH3 CH3 CH3 O H CO2CH3 CH2OCH3 CH3 H O H CO2CH3 CH20CH3 CH3 H O H NO2 CH2OCH3 CH3 H S H Cl CH2OCH3 CH3 H O H H CH2OCH3 CH3 H O H SO2N(CH3)2 CH2OCH3 CH3 CH3 O H SO2N(CH3)C2H5 CH2OCH3 CH3 H O H SO2C2H5 CH2OCH3 CH3 H O H CO2CH3 CH2OC2H5 CH3 H O H Br CH2OCH(CH3)2 CH3 H O H CO2CH3 CH2O(CH2)3CH3 CH3 H O H CO2CH3 CH2CH2OCH3 CH3 H O H Cl CH2CH2OCH(CH3)2 CH3 H O H CO2CH3 N(CH3)2 CH3 H O H CO2CH3 CF3 CH3 H O H SO2CH3 CF3 CH3 H O H CO2CH3 CF3 C2H5 H O H CO2CH(CH3)2 CF3 C2H5 H O H SO2CH3 Table 4 (continued) R1 R2 R3 W R17 R18 m.p.( C) C2H5 H O H Br CF2CF3 CH3 H O H CO2CH3 CF2CF3 CH3 H O H Cl CH3 CH2OCH3 H O H CO2CH3 CH3 CH2SCH3 H O H Cl CH3 CH2CH2OSH3 H O H CO2CH3 CH3 CH2CH2OSH3 H O H Br CH2OCH3 C2H5 H O H CO2CH3 CH2OCH3 CH3 CH3 O H CO2CH3 OC2H5 CH3 CH3 O H SO2(CH2)2CH3 OC2H5 CH3 H O H SO2CH(CH3)2 OC2H5 CH3 H O H SO2N(C2H5)2 OCH3 CH2CF3 H O H CO2CH3 152-155 OCH3 CH3 H O H CH3 OCH3 CH3 H O H C2H5 OCH3 CH3 H O H CH(CH3)2 OCH3 CH3 H O H OCH2CH2CH3 OCH3 CH3 H O H F OCH3 CH3 H O H CO2C2H5 OCH3 CH3 H O H CO2CH2CH2OCH3 OCH3 CH3 H O H CO2CH2CH=CH2 OCH3 CH3 H O H SO2N(CH3)2 OCH3 CH3 H O H SO2N(OCH3)CH3 OCH3 CH3 H O H SO2CH2CH=CH2 SOC2H5 CH3 H O H F OC2H5 CH3 H 0 H Cl OC2H5 CH3 H O H Br OC2H5 CH3 H O H CO2CH3 OC2H5 CH3 H O H SO2N(CH3)2 OC2H5 CH3 H O H SO2CH3 OC2H5 CH3 H O H SO2CH2CH=CH2 Table 4 (continued) EMI99.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> Rl7 <SEP> Rl8 <SEP> m.p.( C) <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> N02 <tb> OCH3 <SEP> 0K2OF3 <SEP> H <SEP> O <SEP> H <SEP> 0020K2OK3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> 502N(CH3)2 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> S02CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> Cl <tb> Ol <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C 2CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2N(CH3)2 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S 2CH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> N02 <tb> NKCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2N(CH3)2 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S020K3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> CH(OCH3)2 <SEP> OK3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> CK(DCK3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> 0020K3 <tb> CH(CCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S02N(0K3)2 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> 3 <SEP> H <SEP> S02C3 <tb> OH3 <SEP> g <SEP> C-83 <SEP> H <SEP> O <SEP> H <SEP> OH3 <tb> Table 4 (continued) EMI100.1 <tb> Rl <SEP> R2 <SEP> R3 <SEP> W <SEP> R17 <SEP> R18 <SEP> m.p.( C) <tb> <SEP> 0E <tb> CH <SEP> OH3 <SEP> H <SEP> O <SEP> H <SEP> OCH <tb> <SEP> ,0 <tb> <SEP> 0 <tb> CH3 <SEP> K <SEP> CH3 <SEP> O <SEP> K <SEP> H <SEP> Cl <tb> <SEP> XOJ <tb> <SEP> ,0E <tb> CH <SEP> I <SEP> CK3 <SEP> H <SEP> O <SEP> H <SEP> NO <tb> <SEP> /01 <tb> ou <SEP> I <SEP> ru <SEP> tl <SEP> n <SEP> Ll <SEP> oro <SEP> oL1 <tb> CH <SEP> OK3 <SEP> H <SEP> O <SEP> K <SEP> C020H3 <tb> <SEP> /0\I <SEP> HOH <SEP> S02N(\ <tb> OK3 <SEP> K <SEP> 0 <SEP> H <SEP> S02N(O)2 <tb> <SEP> 0E <tb> OK <tb> CHo <SEP> j <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S02CH3 <tb> Table 5 EMI101.1 R1 R2 R3 W R17 R18 m.p.( C) H C2H5 H O H CO2CH3 H n-C3H7 H O H CO2CH3 CH3 C2H5 H O H Br CH3 C2H5 H O H CO2CH(CH3)2 CH3 CH2CH(CH3)2 H O H CO2CH3 CH3 C2H5 H O H NO2 CH3 C2H5 H O H H CH3 C2H5 H S H Cl CH3 C2H5 H O H Cl CH3 C2H5 CH3 O H CO2CH2CH=CH2 CH3 C2H5 H O H CO2CH2CH2Cl CH3 C2H5 CH3 O H CO2CH3 CH3 C2H5 CH3 O H SO2CH3 C2H5 CH3 CH3 O H SO2CH3 C2H5 CH3 CH3 O H OCH3 CH3 C2H5 CH3 O H SO2N(CH3)2 CH3 C2H5 H O H NO2 CH3 C2H5 H O H SO2N(CH3)OCH3 C2H5 CH3 H O H SO2CH3 C2H5 CH3 H O 5-F SO2CH3 C2H5 CH3 H O 4-F Br CH3 C2H5 H O 5-Cl Br CH3 C2H5 H O 5-CH3 Cl C2H5 C2H5 H O H Br C2H5 C2H5 H O H CO2CH3 Table 5 (continued) R1 R2 R3 W R17 R18 m.p.( C) C2H5 C2H5 H O H SO2CH2 C2H5 C2H5 H O H SO2N(CH3)C2H5 CH3 C2H5 H O H SO2(CH2)2CH3 C2H5 CH3 H O H SCH3 C2H5 C2H5 CH3 O H SO2CH3 C2H5 C2H5 CH3 O H CO2CH3 C2H5 C2H5 H O H H CH3 C2H5 H O 5-F H CH3 C2H5 H O 5-Cl H C2H5 C2H5 H O H SO2N(CH3)2 C2H5 C2H5 H O H Br CH3 C2H5 H O H F C2H5 C2H5 H O H F n-C3H7 CH3 H O H CO2CH3 CH(CH3)2 CH3 H O H SO2CH3 CH2CH(CH3)2 CH3 H O H CO2C2H5 CH3 N-C3H7 H O H Br CH3 CH2CH=CH2 H O H CO2CH(CH3)2 CH3 CH2C(CH3)=CH2 H O H CO2CH3 CH2CH=CH2 CH3 H O H C2H5 CH2C(CH3)=CH2 CH3 H O H SO2CH3 CH3 CH3C#CCH3 H O H CO2CH3 CH2C#CCH3 CH3 H O H SO2CH3 SCH3 CH3 H S H Br SCH3 CH3 CH3 O H Br SCH3 CH3 H O 4-Cl Br SCH3 CH3 H O 5-OCH3 H SCH3 CH3 H O 5-Cl Cl SCH3 CH3 H O H NO2 SCH3 CH3 H O H SO2N(CH3)C2H5 SCH3 CH3 H O H SO2N(CH3)[CH(CH3)2] Table 5 (continued) R1 R2 R3 W R17 R18 m.p.( C) SCH3 CH3 H O H F SCH3 CH3 H O 5-F H SCH3 CH3 H O 4-Br H SCH3 CH3 H O 5-Br H SCH3 CH3 CH3 O H SO2CH3 SCH3 CH3 CH3 O H CO2CH3 SCH3 CH3 CH3 O H SO2N(CH3)2 SCH3 CH3 H O H OC2H5 SCH3 CH3 H S H H SCH3 CH3 H O H CO2(CH2)3CH3 SCH3 CH3 H O H CO2CH2CH2OCH3 SCH3 CH3 H O 5-Cl H SCH3 CH3 H O H OCH(CH3)C2H5 SCH3 CH3 H O 5-CH3 CH3 SCH3 CH3 H O H SCH3 SCH3 CH3 H O H S(CH2)3CH3 SCH3 C2H5 H O H SO2C2H5 SCH3 CH3 H O H CO2CH(CH3)2 SCH3 CH3 H O H CO2CH3CH=CH2 SCH3 C2H5 H O H CO2CH3 SCH3 C2H5 H O H Br SCH3 C2H5 H O H SO2CH3 SCH3 C2H5 H S H Cl SCH3 C2H5 H O H NO2 SCH3 CH3 H O H CO2CH(CH3)2 SCH3 CH3 H O H CH3 SCH3 CH3 H O H CO2CH3 SCH3 CH3 H O H SO2CH3 SCH3 CH3 H O H Br SCH3 CH3 CH3 O H Cl SCH3 CH3 H S H Br Table 5 (continued) R1 R2 R3 W R17 R18 m.p.( C) SCH(CH3)2 CH3 H O H CO2CH3 S(CH2)3CH3 CH3 H O H SO2CH3 SCH2CH=CH2 CH3 H O H CO2CH3 S(CH2)2CH3 CH3 H O H CO2CH3 SCH2C(CH3)=CH2 CH3 H O H CO2C2H5 SCH2C=CCH3 CH3 H O H CO2CH3 SCH2CO2CH3 CH3 H O H NO2 SCH2CO2(CH2)3CH3 CH3 H O H CO2CH3 SCH(CH3)CO2CH3 CH3 H O H CO2CH3 OCH3 CH3 H O H CO2CH3 OCH3 CH3 H O H SO2N(CH3)C2H5 OCH3 CH3 H O H Br OCH3 CH3 H O H Cl OCH3 CH3 H O H NO2 OCH3 CH3 H S H SO2CH3 OCH3 CH3 CH3 O H SO2CH3 OCH3 CH3 H O H SO2CH3 OCH3 CH3 H O H SO2(CH2)2CH3 OCH3 CH3 H O H OCH3 OC2H5 CH3 H O H O(CH2)3CH3 OC2H5 CH3 H O H CO2CH2CH=CH2 OCH3 CH3 H O H CO2CH2CH2Cl OCH3 C2H5 H O H CO2CH(CH3)2 OCH3 C2H5 H O H CO2(CH2)2CH3 OC2H5 CH3 H O H CO2C2H5 OCH3 C2H5 CH3 O H CO2CH3 OCH3 C2H5 H S H Cl OC2H5 CH3 H S H Br OCH3 C2H5 H O H SO2CH3 OCH3 C2H5 H O H SO2(CH2)3CH3 Table 5 (continued) R1 R2 R3 W R17 R18 m.p.( C) OCH3 C2H5 H O H SO2CH2CH(CH3)2 OCH3 C2H5 CH3 O H SO2CH3 OCH3 C2H5 CH3 O 5-Cl SO2CH3 OCH3 C2H5 CH3 O 5-Br SO2CH3 OCH3 C2H5 H O H OC2H5 OCH3 C2H5 H O H F OCH3 C2H5 H O 5-F F OCH3 C2H5 H O H SC2H5 OC2H5 CH3 H O H SO2N(OCH3)CH3 OC2H5 CH3 H O H SO2N(CH3)[(CH2)2CH3] OC2H5 CH3 H S H H OC2H5 CH3 H S H NO2 OC2H5 CH3 H O H CO2CH(CH3)2 OC2H5 CH3 H O H CO2CH2CH=CH2 OC2H5 CH3 H O H CO2CH2CH2Cl OC2H5 CH3 H O H CH3 OC2H5 CH3 H O H CH(CH3)2 OC2H5 CH3 H O H CH2CH(CH3)2 OC2H5 CH3 CH3 O H CH3 OC2H5 CH3 CH3 O H SO2CH3 OC2H5 CH3 CH3 O H Cl OC2H5 CH3 H O H C2H5 OC2H5 CH3 H O H NO2 OC2H5 CH3 H O 4-Br Br OC2H5 CH3 H O 4-Cl Cl OC2H5 C2H5 H O H Cl OC2H5 C2H5 H O H CO2CH3 OC2H5 C2H5 H O H SO2CH3 OC2H5 C2H5 H O H SO2N(CH3)2 Table 5 (continued) R1 R2 R3 W R17 R18 m.p.( C) OC2H5 C2H5 H O H NO2 OC2H5 C2H5 H O H Br OC2H5 C2H5 H O H CO2CH(CH3)2 O2H3 C2H5 H O H SO2C2H5 OCH3 C2H5 H O 4-F F OC2H5 CH3 H O H OCH(CH3)2 OCH2CH=CH2 CH3 H O H SO2CH3 OCH2C(CH3)=CH2 CH3 H O H CO2CH3 OCH(CH3)C2H5 CH3 H O H CO2CH3 OCH(CH3)2 CH3 H O H CO2CH3 O(CH2)2#CCH3 CH3 H O H Cl CH2OCH3 CH3 H O H NO2 CH2OCH3 CH3 H O H Br CH2OCH3 CH3 CH3 O H Cl CH2OCH3 CH3 CH3 O H SO2CH3 CH2OCH3 CH3 H O H CO2CH3 CH2OCH3 CH3 H O H CO2CH3 CH2OCH3 CH3 H S H NO2 CH2OCH3 CH3 H O H Cl CH2OCH3 CH3 H O H H CH2OCH3 CH3 H O H SO2N(CH3)2 CH2OCH3 CH3 CH3 O H SO2N(CH3)C2H5 CH2OCH3 C2H5 H O H SO2C2H5 CH2OCH3 C2H5 H O H CO2CH5 CH2OC2H5 CH3 H O H Br CH2OCH(CH3)2 CH3 H O H CO2CH5 CH2O(CH2)3CH3 CH3 H O H CO2CH3 CH2CH2OCH3 CH3 H O H Cl CH2CH2OCH(CH3)2 CH3 H O H CO2CH3 N(CH3)2 CH3 H O H CO2CH3 CF3 CH3 H O H SO2CH3 Table 5 (continued) R1 R2 R3 W R17 R18 m.p.( C) CF3 CH3 H O H CO2CH3 CF3 C2H5 H O H CO2CH(CH3)2 CF3 C2H5 H O H SO2CH3 CF3 C2H5 H O H Br CF2CF3 CH3 H O H C02CH3 CF2CF3 CH3 H O H Cl CH3 CH2OCH3 H O H CO2CH3 CH3 CH2SCH3 H O H Cl CH3 CH2CH2OCH3 H O H CO2CH3 CH3 CH2CH2SCH3 H O H Br CH2OCH3 C2H5 H O H CO2CH5 CH2OCH3 CH3 CH3 O H CO2CH3 OC2H5 CH3 CH3 O H So2(CH2)2CH3 OC2H5 CH3 H O H SO2CH(CH3)2 OC2H5 CH3 H O H SO2N(C2H5)2 OC2H5 CH3 H O H CH3 OC2H5 CH3 H O H C2H5 OCH3 CH3 H O H CH(CH3)2 OCH3 CH3 H O H OCH2CH2CH3 OCH3 CH3 H O H F OCH3 CH3 H O H CO2C2H5 OCH3 CH3 H O H CO2CH2CH2OCH3 OCH3 CH3 H O H C02CH2CH=CH2 OCH3 CH3 H O H SO2N(CH3)2 OCH3 CH3 H O H SO2N(OCH3)CH3 OCH3 CH3 H O H SO2CH2CH0CH2 OC2H5 CH3 H O H F OC2H5 CH3 H O H Cl OC2H5 CH3 H O H Br OC2H5 CH3 H O H CO2CH3 OC2H5 CH3 H O H SO2N(CH3)2 Table 5 (continued) EMI108.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R17 <SEP> R18 <SEP> m.D.( C) <tb> <SEP> 17 <SEP> ¯ <tb> OC2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2CH3 <tb> OC2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> 502CK20.H=CK2 <tb> OCH3 <SEP> C <SEP> D <SEP> CF3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> OCH3 <SEP> CCF3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> OCH3 <SEP> CH2Cf3 <SEP> H <SEP> O <SEP> H <SEP> N02 <tb> OCH3 <SEP> C <SEP> F <SEP> CF3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH2CH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> S02N(CH3)2 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> SO2CK3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2N(0K3)2 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2CH3 <tb> NKOH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> N02 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2N(CH3)2 <tb> NHCH3 <SEP> CH3. <SEP> H <SEP> O <SEP> H <SEP> 502CH3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> CH(3CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> CK(CCK3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH3 <tb> CH(3CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> 502N(CH3)2 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2CH3 <tb> <SEP> OK3 <SEP> H <SEP> O <SEP> K <SEP> 0H <tb> <SEP> XO <SEP> - <SEP> 3 <SEP> ; ; <tb> Table 5 (continued) EMI109.1 <tb> Rl <SEP> R2 <SEP> R3 <SEP> W <SEP> R17 <SEP> R18 <SEP> m.p.(0C) <tb> <SEP> L <tb> CXHog <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> <SEP> /0 > <tb> CXH <SEP> J <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> <SEP> 0 <tb> OK0 <SEP> 2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> <SEP> 0 <tb> CH <SEP> K <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C 2CH3 <tb> <SEP> /0 > <tb> OH) <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S02N(CH3) <tb> <SEP> /0E <tb> ·'KOG) <SEP> OH3 <SEP> K <SEP> 0 <SEP> K <SEP> 5020K3 <tb> Table 6 EMI110.1 R1 R2 R3 W R17 R18 m.p.( C) H C2H5 H O H CO2CH3 H n-C3H7 H O H CO2C2H5 CH3 C2H5 H O H Br CH3 C2H5 H O H CO2CH(CH3)2 CH3 CH2CH(CH3)2 H O H CO2CH3 CH3 C2H5 H O H NO2 CH3 C2H5 H O H H CH3 C2H5 H S H Cl CH3 C2H5 H O H Cl CH3 C2H5 CH3 O H CO2CH2=CH23 CH3 C2H5 H O H CO2CH2CH2Cl CH3 C2H5 CH3 O H CO2CH3 CH3 C2H5 CH3 O H SO2CH3 C2H5 CH3 CH3 O H SO2CH3 C2H5 CH3 CH3 O H OCH3 CH3 C2H5 CH3 O H SO2N(CH3)2 CH3 C2H5 H S H NO2 CH3 C2H5 H O H SO2N(CH3)OCH3 C2H5 CH3 H S H SO2CH3 C2H5 CH3 H O 5-F SO2CH3 C2H5 CH3 H O 2-F Br CH3 C2H5 H O 5-Cl Br CH3 C2H5 H O 5-CH3 Cl C2H5 CH3 H O H Br C2H5 CH3 H O H CO2CH3 Table 6 (continued) R1 R2 R3 W R17 R18 m.p.( C) C2H5 C2H5 H O H SO2CH3 C2H5 C2H5 H O H SO2N(CH3)C2H5 CH3 C2H5 H O H SO2(CH2)2CH3 C2H5 CH3 H O H SCH3 C2H5 C2H5 CH3 O H SO2CH3 C2H5 C2H5 CH3 O H CO2CH3 C2Hs C2H5 H O H H CH3 C2H5 H O 5-F H CH3 C2H5 H O 5-Cl H C2H5 C2H5 H O H SO2N(CH3)2 C2H5 C2H5 H S H Br CH3 C2H5 H O H F C2H5 C2H5 H O H F n-C3H7 CH3 H O H CO2CH3 CH(CH3)2 CH3 H O H SO2CH3 CH2CH(CH3)2 CH3 H O H CO2C2H5 CH3 n-C3H7 H O H Br CH3 CH2CH=CH2 H O H CO2CH(CH3)2 CH3 CH2C(CH3)=CH2 H O H CO2CH3 CH2CH=CH2 CH3 H O H C2H5 CH2C(CH3)=CH2 CH3 H O H SO2CH3 CH3 CH2C#CCH3 H O H CO2CH3 CH2C#CCH3 CH3 H O H SO2C2H5 SCH3 CH3 H S H Br SCH3 CH3 CH3 O H Br SCH3 CH3 H O 2-Cl Br SCH3 CH3 H O 5-0CH3 H SCH3 CH3 H O 5-Cl Cl SCH3 CH3 H O H NO2 SCH3 CH3 H O H SO2N(CH3)C2H5 SCH3 CH3 H O H SO2N(CH3)[CH(CH3) Table 6 (continued) R1 R2 R3 W Ri7 R18 m.p.( C) SCH3 CH3 H O H F SCH3 CH3 H O 5-F H SCH3 CH3 H O 2-Br H SCH3 CH3 H O 5-Br H SCH3 CH3 CH3 O H SO2CH3 SCH3 CH3 CH3 O H C02CH3 SCH3 CH3 CH3 O H SO2N(CH3)2 SCH3 CH3 H O H OC2H5 SCH3 CH3 H S H H SCH3 CH3 H O H CO2(CH2)3CH3 SCH3 CH3 H O H CO2CH2CH2OCH3 SCH3 CH3 H O 5-Cl H SCH3 CH3 H O H OCH(CH3)C2H5 SCH3 CH3 H O 5-Cl CH3 SCH3 CH3 H O H SCH3 SCH3 CH3 H O H S(CH2)3CH3 SCH3 C2H5 H O H CO2C2H5 SCH3 CH3 H O H CO2CH(CH3)2 SCH3 CH3 H O H CO2CH2CH=CH2 SCH3 C2H5 H O H CO2CH3 SCH3 C2H5 H O H Br SCH3 C2H5 H O H SO2CH3 SCH3 C2H5 H S H Cl SCH3 C2H5 H O H NO2 SC2H5 CH3 H O H CO2CH(CH3)2 SC2H5 CH3 H O H CH3 SC2H5 CH3 H O H CO2CH3 SC2H5 CH3 H O H SO2CH3 SC2H5 CH3 H O H Br SC2H5 CH3 CH3 O H Cl SC2H5 CH3 H S H Br Table 6 (continued) R1 R2 R3 W R17 R18 m.p.( C) SCH(CH3)2 CH3 H O H CO2CH3 S(CH2)3CH3 CH3 H O H SO2CH3 SCH2CH=CH2 CH3 H O H CO2CH3 S(CH2)2CH3 CH3 H O H CO2CH3 SCH2C(CH3)=CH2 CH3 H O H CO2CH3 SCH2C#CCH3 CH3 H O H CO2CH3 SCH2CO2CH3 CH3 H O H NO2 SCH2CO2(CH2)3CH3 CH3 H O H CO2CH3 SCH(CH3)CO2CH3 CH3 H O H CO2CH3 OCH3 CH3 H O H CO2CH3 OCH3 CH3 H O H SO2N(CH3)C2H5 OCH3 CH3 H O H Br OCH3 CH3 H O H Cl OCH3 CH3 H O H NO2 OCH3 CH3 H S H SO2CH3 OCH3 CH3 CH3 O H SO2CH3 OCH3 CH3 H O H 502CH3 OCH3 OH3 H O H SO2(CH2)2CH3 OCH3 CH3 H O H OCH3 OC2H5 CH3 H O H O(CH2)3CH3 OC2H5 CH3 H O H CO2CH2CH=CH2 OCH3 CH3 H O H CO2CH2CH2Cl OCH3 C2H5 H O H CO2CH(CH3)2 OCH3 C2H5 H O H CO2(CH2)2CH3 OC2H5 CH3 H O H CO2C2H5 OCH3 C2H5 CH3 O H CO2CH3 OCH3 C2H5 H S H Cl OC2H5 CH3 H S H Br OCH3 C2H5 H O H SO2CH3 OCH3 C2H5 H O H SO2(CH2)3CH3 Table 6 (continued) R1 R2 R3 W R17 R18 m.p.( ) OCH3 C2H5 H O H SO2CH2CH(CH3)2 OCH3 C2H5 CH3 O H SO2CH3 OCH3 C2H5 CH3 O 5-Cl SO2CH3 OCH3 C2H5 CH3 O 5-Br SO2CH3 OCH3 C2H5 H O H OC2H5 OCH3 C2H5 H O H F OCH3 C2H5 H O 5-F F OCH3 C2H5 H O H SC2H5 OC2H5 CH3 H O H SO2N((OCH3)CH3 OC2H5 CH3 H O H SO2N(CH3)[(CH2)2CH3] OC2H5 CH3 H S H H OC2H5 CH3 H S H NO2 OC2H5 CH3 H O H CO2CH(CH3)2 OC2H5 CH3 H O H CO2CH2CH=CH2 OC2H5 CH3 H O H CO2CH2CH2Cl OC2H5 CH3 H O H CH3 OC2H5 CH3 H O H CH(CH3)2 OC2H5 CH3 H O H CH2CH(CH3)2 OC2H5 CH3 CH3 O H CH3 OC2H5 CH3 CH3 O H SO2CH3 OC2H5 CH3 CH3 O H Cl OC2H5 CH3 H O H C2H5 OC2H5 CH3 H O H NO2 OC2H5 CH3 H O 2-Br Br OC2H5 CH3 H O 2-Cl Cl OC2H5 C2H5 H O H Cl OC2H5 C2H5 H O H CO2CH3 OC2H5 C2H5 H O H SO2CH3 OC2H5 C2H5 H O H SO2N(CH3)2 Table 6 (continued) R1 R2 R3 W R17 R18 m.p.( C) OC2H5 C2H5 H O H NO2 OC2H5 C2H5 H O H Br OC2H5 C2H5 H O H CO2CH(CH3)2 OC2H5 C2H5 H O H SO2C2H5 OCH3 C2H5 H O 2-F F OC2H5 CH3 H O H OCH(CH3)2 OCH2CH=CH2 CH3 H O H SO2CH3 OCH2C(CH3)=CH2 CH3 H O H CO2CH3 OCH(CH3)C2H5 CH3 H O H CO2CH3 OCH(CH3)2 CH3 H O H CO2C2H5 O(CH2)2CH3 CH3 H O H Cl OCH2C#CCH3 CH3 H O H NO2 CH2OCH3 CH3 H O H Br CH2OCH3 CH3 H O H Cl CH2OCH3 CH3 CH3 O H SO2CH3 CH2OCH3 CH3 CH3 O H C02CH3 CH20CH3 CH3 H O H CO2CH3 CH2OCH3 CH3 H O H NO2 CH2OCH3 CH3 H S H Cl CH2OCH3 CH3 H O H H CH2OCH3 CH3 H O H SO2N(CH3)2 CH2OCH3 CH3 CH3 O H SO2N(CH3)C2H5 CH2OCH3 C2H5 H O H SO2C2H5 CH2OCH3 C2H5 H O H CO2CH3 CH2OC2H5 CH3 H O H Br CH2OCH(CH3)2 CH3 H O H CO2CH3 CH2O(CH2)3CH3 CH3 H O H CO2CH3 CH2CH2OCH3 CH3 H O H Cl CH2CH2OCH(CH3)2 CH3 H O H CO2CH3 N(CH3)2 CH3 H O H CO2CH3 CF3 CH3 H O H SO2CH3 Table 6 (continued) R1 R2 R3 w R17 R17 m.p.( C) CF3 CH3 H O H CO2CH3 CF3 C2H5 H O H CO2CH(CH3)2 CF3 C2H5 H O H SO2CH3 CF3 C2H5 H O H Br CF2CF3 CH3 H O H CO2CH3 CF2CF3 CH3 H O H Cl CH3 CH2OCH3 H O H CO2CH3 CH3 CH2SCH3 H O H Cl CH3 CH2CH2OCH3 H O H CO2CH3 CH3 CH2CH2SCH3 H O H Br CH2OCH3 C2H5 H O H CO2CH3 CH2OCH3 CH3 CH3 O H CO2CH3 OC2H5 CH3 CH3 O H SO2(CH2)2CH3 OC2H5 CH3 H O H SO2CH(CH3)2 OC2H5 CH3 H O H SO2N(C2H5)2 OCH3 CH3 H O H CH3 OCH3 CH3 H O H C2H5 OCH3 CH3 H O H CH(CH3)2 OCH3 CH3 H O H OCH2CH2CH3 OCH3 CH3 H O H F OCH3 CH3 H O H CO2C2H5 OCH3 CH3 H O H CO2CH2CH2OCH3 OCH3 CH3 H O H CO2CH2CH2=CH2 OCH3 CH3 H O H SO2CH(CH3)2 OCH3 CH3 H O H SO2N(C2H5)2 OCH3 CH3 H O H SO2CH2CH=CH2 OC2H5 CH3 H O H F OC2H5 CH3 H O H Cl OC2H5 CH3 H O H Br OC2H5 CH3 H O H CO2CH3 OC2H5 CH3 H O H SO2N(CH3)2 Table 6 (continued) EMI117.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R17 <SEP> R18 <SEP> m.p.(oC) <tb> OC2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2CH3 <tb> OC2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2CH2CH <SEP> C <SEP> 2 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> OCH3 <SEP> OH2CF3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH2CH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> S02N(CH3)2 <tb> OCH3 <SEP> C¸OF3 <SEP> H <SEP> O <SEP> H <SEP> SO2CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH; ; <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> 002OR3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2N(CH3)2 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S02OH3 <tb> NKOH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> OCH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> Cl <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CH3 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> 502N(0K3)2 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> SO2CH3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> 3CH3 <tb> CH(5CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> CH(CCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> NO2 <tb> CH(CCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S02N(CH;)2 <tb> CH(aCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> s <tb> <SEP> /0E <tb> OH3 <SEP> H <SEP> O <SEP> H <SEP> 0 <SEP> .3 <tb> Table 6 (continued) EMI118.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R17 <SEP> R18 <SEP> m.p.(00) <tb> <SEP> 2 <SEP> F <tb> <SEP> /01 <tb> OK3 <SEP> CH, <SEP> H <SEP> o <SEP> H <SEP> OCH3 <tb> <SEP> 0 <tb> CH <SEP> 2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> Cl <tb> <SEP> /0 > <tb> OK3 <SEP> H <SEP> 0 <SEP> H <SEP> N02 <tb> <SEP> \01 <tb> CH <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C 2CH3 <tb> <SEP> Om <tb> o0) <SEP> g <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> S02N(CH3)2 <tb> CsHog <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> 502CH3 <tb> Table 7 EMI119.1 R1 R2 R3 W R17 R18 m.p.( C) H n-C3H7 H O H CO2CH3 CH3 CH(CH3)2 H O H CO2CH(CH3)2 CH3 CH3 H O H CO2CH2CH=CH2 n-C4H9 CH3 H O H Cl CH2CH=CHCH3 CH3 H O H Br CH2C#CCH3 CH3 H O H CH3 SCH3 CH3 H O H CO2CH(CH3)C2H5 SCH2CH=CH2 CH3 H O H Cl S(CH2)3CH3 CH3 H O H Br SCH(CH3)2 CH3 H O H CO2C2H5 SCH3 CH3 CH3 O H CH3 SCH2C#CCH3 CH3 H O H CO2CH3 SCH2CO2CH(CH3)2 CH3 H O H Cl SCH(CH3)CO2C2H5 CH3 H O H Br N(CH3)2 CH3 H O H CO2CH2CH2CH3 CF3 C2H5 CH3 O H H CF2CF3 CH3 H S H CO2CH2CH2Cl CC2H5 CH3 H S H CH3 OCH2CH(CH3)2 CH3 H O H CO2CH3 CH2OCH3 CH3 CH3 O H CO2CH2CH2OCH3 CH2OCH(CH3)2 CH3 H O H CO2CH(CH3)2 CH2OCH3 CH3 H S H Cl CH3 CH2CH2OCH3 H O H Cl CH3 CH2SCH3 H O H Br CH3 CH2OCH3 H O H CO2CH2CH(CH3)2 Table 7 (continued) R1 R2 R3 w R17 R18 m.p.( C) CH3 CH2CH2SCH3 H O H CO2CH3 SCH3 -C3H7 H S H CH3 CH3 CH2CH2(CH3)2 H O H Cl OC2H5 CH3 H O H CO2CH3 OCH3 CH3 CH3 O H Cl OCH3 CH3 H O H CO2CH3 C2H5 CH3 H S H Br SCH3 CH3 H O H CO2CH3 CH2OCH2CH2CH3 CH3 H O H CH3 SCH3 CH2C(CH3)=CH2 H O H Cl OC2H5 CH3 CH3 S H CH3 OC2H5 CH3 H O H CO2CH(CH3)2 CH2OCH3 CH3 H O H CO2CHCH=CH2 SC2H5 CH3 H O H CO2C2H5 CF2CF3 CH3 H O H CO2CH3 CF3 C2H5 H O H C 2CH3 CH3 CH2CH=CH2 H O H CO2CH3 CH3 CH2#CCH3 H O H CH3 SCH3 CH3 CH3 O H CO2CH(CH3)2 SCH3 CH3 H O H H SCH3 CH3 CH3 O H H SCH(CH3)CO2CH3 C2H5 H O H SO2CH3 SCH3 C2H5 H O H CO2CH3 CH2CH2OCH(CH3)2 CH3 H O H Cl SCH3 CH3 H O H H OCH2CH=CH2 CH3 H O H CO2C2H5 OCH3 C2H5 H O H Br CH2CH2OCH3 CH3 H O H CO2CH3 SCH2CO2C2H5 CH3 H O H SO2CH3 OCH2C#CH CH3 H O H CH3 OC2H5 CH3 CH3 O H CO2CH3 Table 7 (continued) R1 R4 R3 w R17 R18 m.p.( C) OC2H5 CH3 H O H CO2CH2CH=CH2 OC2H5 CH3 H O H CO2CH2CH2OCH3 OC2H5 CH3 H O H CO2CH(CH3)C2H5 OC2H5 CH3 H O H Br OC2H5 CH3 H O H Cl OC2H5 CH3 H O H H OC2H5 CH3 H O H CO2(CH2)3CH3 SCH3 CH3 H O H CO2CH2CH=CH2 SCH3 CH3 H O H CO2C2H5 SCH3 CH3 H O H CH3 SCH3 CH3 H O H CO2(CH2)2CH3 SCH3 CH3 H O H Br SCH3 CH3 H O H Cl SCH3 CH3 CH3 O H Cl SCH3 CH3 CH3 O H Br SCH3 CH3 CH3 O H CO2CH3 SCH3 CH3 H O H CH3 SCH3 C2H5 H O H CO2C2H5 SCH3 C2H5 H O H Br OCH3 C2H5 H O H CO2(CH2)3CH3 OCH3 C2H5 H O 4-Br H OCH3 C2H5 H O 4-Br CO2CH3 OCH3 C2H5 H O 5-Cl CO2CH3 OCH3 C2H5 H O 4-Cl CO2CH3 OCH3 C2H5 H O 4-CH3 CO2CH3 OCH3 C2H5 H O H CO2CH2CH=CH2 OCH3 C2H5 H O H CO2CH(CH3)2 OCH3 CH3 H O H H OCH3 CH3 H O H Cl OCH3 CH3 H O H Br OCH3 CH3 H O H CH3 Table 7 (continued) EMI122.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R17 <SEP> R18 <SEP> m.P.( C) <tb> <SEP> 1 <SEP> 2 <SEP> 3 <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH3 <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2O2K5 <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH(CH3)2 <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CK2CKH3 <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2(CH2)3CH3 <tb> OCH3 <SEP> CH3 <SEP> K <SEP> O <SEP> H <SEP> CO2CH2CH20CH3 <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH2CH2C1 <tb> OCH3 <SEP> CH3 <SEP> HOH <SEP> CO2CH2CH <SEP> CH2 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> H <tb> OCH3 <SEP> C <SEP> s <SEP> CF3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH3 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> OG2OH2OK=0H2 <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH2CH2C1 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C1 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CH2CH=CH2 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> Sr <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2C2H5 <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C 2C <SEP> 2C <SEP> 2C1 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> CO2CH3 <tb> <SEP> 0 <tb> CHO <SEP> X <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> C02CH3 <tb> Table <RTI ID=123.1> 8 EMI123.1 R1 R2 R3 w R9 R17 m.p.( C) H n-C3H7 H O CH3 H H C2H5 H O C2H5 H CH3 CH(CH3)2 H O CH3 H CH3 CH3 H S CH(CH3)2 H n-C4Hg CH3 H O CH3 H CH2CH=CH2 CH3 H O CH3 H CH2C(CH3)=CH2 CH3 H O CH3 H CH2C#CCH3 CH3 H O CH3 H SCH2CH=CH2 CH3 H O C2H5 H SCH2CH(CH3)2 CH3 H O CH3 H SCH2C#CH CH3 H O CH3 H SC2H5 CH3 H O CH(CH3)C2H5 H SCH3 CH3 CH3 O CH2CH2Cl H SCH2CO2C2H5 CH3 H O C2H5 H N(CH3)2 CH3 H O CH3 H CF C2H5 H O CH2CH2OCH3 H CF2CF2 CH3 H O n-C3H7 H OC2H5 CH3 CH3 O CH(CH3)C2H5 H OCH2CH(CH3)2 CH3 H O CH3 H OCH(CH3)2 CH3 H O C2H5 H CH2OCH3 CH3 H S CH3 H CH3 CH2CH2OCH3 H O CH3 H CH3 CH2SCH3 H O CH3 H CH3 CH2OCH3 H O CH(CH3)2 H Table 8 (continued) R1 R2 R3 w R9 R17 m.p.( C) CH3 CH2CH2SCH3 H H O CH3 H SCH3 n-C3H7 H O CH3 H CH3 CH2CH(CH3)2 H O CH3 H OC2H5 CK3 H O CH3 H OCH3 CH3 CH3 O CH3 H OCH3 C2H5 H O CH3 5-Cl OCH3 C2H5 H O CH3 5-Br CH3 CH2CH=CH2 H O CH3 H CH3 CH2CH=CHCH3 H O CH3 H CH3 CH2C#CCH3 H O CH3 H OC2H5 CH3 H O CH3 4-Cl OCH3 C2H5 H O CH2CH2Cl H C2H5 CH3 H S CH2CH2OCH3 H SCH3 CH3 H O CH(CH3)C2H5 H CF3 C2H5 H O CH2CH=CH2 H CH2CH2OC2H5 CH3 H O CH(CH3)2 H CH2O-CH2CH(CH3)2 CH3 H O C2H5 4-CH3 OCH3 C2H5 CH3 O n-C4H9 H SCH3 CH3 H O n-C3H7 H CH2OCH3 CH3 CH3 O CH3 H CH2OCH3 CH3 H O C2H5 H CF2CF3 C2H5 H O CH3 H OCH3 C2H5 H S CH(CH3)C2H5 H OCH3 C2H5 H S CH3 5-OCH3 SCH3 CH3 H S CH3 H S-n-C3H7 CH3 H O CH3 H OC2H5 C2H5 H O CH3 H OCH2C#CH C2H5 H O CH3 H CH3 C2H5 H O CH(CH3)2 H SCH3 CH3 H O n-C3H7 H OCH2CH=CH2 CH3 H O CH3 H Table 8 (continued) R1 R2 R3 w R9 R17 m.p.( C) SCH3 CH3 H O CH3 H SCH3 CH3 H O C2H5 H SCH3 C2H5 H O CH3 H SCH3 C2H5 H O C2H5 H SCH3 CH3 H O CH2CH=CH2 H SCH3 CH3 H O CH2(CH3)2 H SCH3 CH3 CH3 S CH3 H SCH3 CH3 H S C2H5 H OC2H5 CH3 H O CH3 5-F OC2H5 CH3 H O C2H5 5-Cl OC2H5 CH3 H O CH3 5-Br OC2H5 CH3 H O CH(CH3)2 H OC2H5 CH3 H O CH3 4-Br OC2H5 CH3 H O CH3 5-CH3 OC2H5 CH3 H S CH3 H OC2H5 CH3 CH3 O CH3 H OC2H5 CH3 CH3 O CH(CH3)2 H OC2H5 CH3 CH3 O CH2CH=CH2 H OC2H5 CH3 H O n-C4H9 H OC2H5 CH3 H O CH2CH(CH3)2 H OC2H5 CH3 H O n-C3H7 H OCH3 C2H5 H O CH3 H OCH3 C2H5 H S CH3 H OCH3 C2H5 H O CH3 4-F OCH3 C2H5 H O CH3 5-F OCH3 C2H5 CH3 O CH3 H OCH3 C2H5 CH3 O CH2CH=CH2 H OCH3 CH3 H O CH3 H OCH3 CH3 H O CH(CH3)2 H OCH3 CH3 H O C2H5 H OCH3 CH3 H O CH2CH2CH3 H Table 8 (continued) EMI126.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R9 <SEP> R17 <SEP> m.O.(OC) <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH=CH2 <SEP> -K <tb> OCHA <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH20CH3 <SEP> H <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> OC2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> YOCK3 <SEP> CF3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> YOCK3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> C2K5 <SEP> H <tb> OCH3 <SEP> CF3 <SEP> H <SEP> O <SEP> CK(0H3)2 <SEP> H <tb> OCH3 <SEP> 2CF3 <SEP> H <SEP> O <SEP> CH2CH <SEP> CH2 <SEP> H <tb> OCH3 <SEP> C <SEP> 2CF3 <SEP> H <SEP> O <SEP> CH2CH20CH3 <SEP> H <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> C1 <SEP> CH3 <SEP> K <SEP> 0 <SEP> O2K3 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH=CH2 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CK3 <SEP> K <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH20CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C2H3 <SEP> H <tb> CH(OCCH <SEP> OK3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> C2K5 <SEP> H <tb> CH(OCH3)2 <SEP> CH <SEP> H <SEP> O <SEP> CH(CH3)2 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH-GH2 <SEP> K <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> <SEP> 0 <tb> CH <SEP> ) <SEP> CHg <SEP> H <SEP> O <SEP> OK3 <SEP> H <tb> <SEP> ,0 <tb> <SEP> ,0E <tb> 0K0 <SEP> g <SEP> OK3 <SEP> H <SEP> O <SEP> CH2CH2CH) <SEP> H <tb> r,H <tb> C, <SEP> CH3 <SEP> H <SEP> O <SEP> CH2OK2GOK3 <SEP> H <tb> <SEP> ,0E <tb> CH <SEP> I <SEP> CH <SEP> H <SEP> O <SEP> CH2CH21 <SEP> H <tb> <SEP> \0¯; <SEP> v <SEP> 2 <SEP> 2 <tb> Table 9 EMI127.1 R1 R2 R3 W R9 R17 m.p.( C) H n-C3H7 H O CH3 H CH3 C2H5 H O C2H5 H CH3 CH(CH3)2 H O CH3 H CH3 CH3 H O CH3 H n-C4H9 CH3 H O CH3 H CH2CH=CH2 CH3 H O CH3 H CH2CH(CH3)=CH CH3 H O CH3 H CH3C#CCH3 CH3 H O CH3 H SCH2CH=CH2 CH3 H O CH3 H CH(CH3)C2H5 CH3 H O CH3 H SCH2(CH3)2 CH3 H O CH3 H SCH2C#CH CH3 H O CH3 H SC2H5 CH3 H O CH3 H SCH3 CH3 CH3 O CH3 H SCH2CO2CH(CH3)2 CH3 H O CH3 H N(CH3)2 CH3 H O CH3 H SCH3 CH3 CH3 O CH3 H SCH3 CH3 H S C2H5 H SCH3 CH3 H O CH(CH3)C2H5 H SCH3 CH3 H O CH2CH2OCH3 H SCH3 C2H5 H O CH(CH3)2 H CF3 C2H5 H O CH2CH=CH2 H CF2CF2 CH3 H S CH3 H OC2H5 CH3 H O n-C3H7 H OCH2CH(CH3)2 CH3 H O CH3 H Table 9 (continued) R1 R2 R3 w R9 R17 m.p( C) OCH(CH3)2 CH3 H S CH3 H CH2OCH3 CH3 H O CH2CH2Cl H SCH2CO2CH3 CH3 H O CH3 H SCH(CH3)CO2C2H5 CH3 H O CH3 H CH3 CH2CH2OCH3 H O CH3 H CH3 CH25CH3 H O CH(CH3)2 H CF3 CH2OCH3 H S C2H5 H CH2OCH(CH3)2 CH3 H O CH3 H CH2CH2OC2H5 CH3 H O CH3 H SCH3 n-C3H7 CH3 O CH3 H OC2H5 CH3 CH3 S CH3 H OCH3 CH3 CH3 O CH3 H OCH3 CH3 H O CH3 5-C1 OCH3 C2H5 H O CH3 2-Br OCH3 C2H5 H S CH3 H C2H5 CH3 H O CH3 5-CH3 CH3 CH2CH=CH2 H O n-C3H7 H CH3 CH2CH(CH3)2 H O CH(CH3)2 H CH3 CH2C#C-CH3 H O CH3 H OC2H5 CH3 CH3 O C2H5 H CF3 C2H5 H S CH3 H OCH2CH=CH2 CH3 H O CH3 H OCH2C#CH CH3 H O CH3 H SCH3 CH3 H O CH2CH2OCH3 H SCH3 CH3 H O CH2CH2Cl H CG2CF3 CH3 CH3 O CH3 H OCH3 C2H5 CH3 O CH3 H OCH3 C2H5 H O CH2CH=CH2 H CH2OCH3 CH3 H O CH3 H SCH3 CH3 H O CH3 H Table 9 (continued) R1 R2 R3 W R9 R17 m.p.( C) SCH3 CH3 H O CH3 H SCH3 CH3 H O C2H5 H SCH3 C2H5 H O CH3 H SCH3 C2H5 H O C2H5 H SCH3 CH3 H O CH2CH=CH2 H SCH3 CH3 H O CH2(CH3)2 H SCH3 CH3 CH3 O CH3 H SCH3 CH3 H O C2H5 H OC2H5 CH3 H O CH3 5-F OC2H5 CH3 H O C2H5 5-Cl OC2H5 CH3 H O CH3 5-Br OC2H5 CH3 H O CH(CH3)2 H OC2H5 CH3 H O CH3 2-Br OC2H5 CH3 H O CH3 5-CH3 OC2H5 CH3 H O CH3 H OC2H5 CH3 CH3 O CH3 H OC2H5 CH3 CH3 O CH(CH3)2 H OC2H5 CH3 CH3 O CH2CH=CH2 H OC2H5 CH3 H O n-C4H9 H OC2H5 CH3 H O CH2CH(CH3)2 H OC2H5 CH3 H O n-C3H7 H OCH3 C2H5 H O CH3 H OCH3 C2H5 H O CH3 H OCH3 C2H5 H O CH3 2-F OCH3 C2H5 H O CH3 5-F OCH3 C2H5 CH3 O CH3 H OCH3 C2H5 CH3 O CH2OH=CH2 H OCH3 CH3 H O CH3 H OCH3 CH3 H O CH(CH3)2 H OCH3 CH3 H O C2H5 H OCH3 CH3 H O CH2CH2CH3 H Table 9 (continued) EMI130.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R9 <SEP> R17 <SEP> m.p,(oC) <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CK2CK=OK2 <SEP> H <tb> OOK3 <SEP> OK3 <SEP> H <SEP> O <SEP> CH2CH20CH3 <SEP> H <tb> OCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> OCH3 <SEP> CH3 <SEP> K <SEP> O <SEP> OKOK2OK2OK3 <SEP> 2C <SEP> 3K <tb> OC2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> OK3 <SEP> H <tb> GCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> O2K5 <SEP> H <tb> YOCK3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> CH(CH3)2 <SEP> H <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> CH2CH=CH2 <SEP> H <tb> OCH3 <SEP> CCF3 <SEP> K <SEP> O <SEP> O <SEP> CH2CH20CH3 <SEP> H <tb> OCH, <SEP> CH2CF3 <SEP> H <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> 02K5 <SEP> K <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH <SEP> CH2 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> NHCH; <SEP> K <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH20CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> 02K5 <SEP> K <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> . <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> 02H5 <SEP> H <tb> CH(OCH3)2 <SEP> CH <SEP> H <SEP> O <SEP> CH(CH3)2 <SEP> H <tb> CH(CCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH=CH2 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> CH2CH2C1 <SEP> H <tb> CH <SEP> I <SEP> OK3 <SEP> H <SEP> O <SEP> OK3 <SEP> H <tb> <SEP> \ol <tb> C <SEP> C, <SEP> H <SEP> O <SEP> C,CH,C, <SEP> H <tb> <SEP> OH3 <SEP> H <SEP> 0 <SEP> 0H20H20K3 <SEP> H <tb> c;r <SEP> 1 <SEP> CH3 <SEP> H <SEP> O <SEP> 3e: :i, <SEP> H <tb> <SEP> \0) <SEP> c <SEP> L <SEP> I <tb> <SEP> 0 > <tb> \5¯J <SEP> OH3 <SEP> H <SEP> 2 <SEP> CH2CH2Cl <tb> Table 10 EMI131.1 EMI131.2 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R14 <SEP> R15 <SEP> m.p.(OC) <tb> H <SEP> n-C3H7 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> K <SEP> 02K5 <SEP> H <SEP> O <SEP> Br <SEP> H <tb> CH3 <SEP> C2K5 <SEP> H <SEP> O <SEP> F <SEP> H <tb> C2H5 <SEP> OK3 <SEP> H <SEP> O <SEP> H <SEP> H <tb> CH3 <SEP> CH(CH3)2 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> CH3 <SEP> CK(CK3)02K5 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> CH3 <SEP> n¯C3H7 <SEP> H <SEP> S <SEP> C1 <SEP> H <tb> n¯C3H7 <SEP> CH3 <SEP> H <SEP> O <SEP> OCH3 <SEP> H <tb> CH(CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> CH(CH3)C2H5 <SEP> CH3 <SEP> H <SEP> O <SEP> Br <SEP> H <tb> n¯C4H9 <SEP> CH3 <SEP> H <SEP> O <SEP> C1 <SEP> H <tb> 025 <tb> K <SEP> CH3 <SEP> H <SEP> O <SEP> NO2 <SEP> 4-C1 <tb> O2K5 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> 8-N02 <tb> CH3 <SEP> 02H5 <SEP> H <SEP> O <SEP> C1 <SEP> 3-C1 <tb> CH3 <SEP> C2K5 <SEP> H <SEP> O <SEP> N02 <SEP> 5-Br <tb> CH3 <SEP> 02K5 <SEP> CH3 <SEP> O <SEP> NO2 <SEP> H <tb> C2K5 <SEP> CH3 <SEP> H <SEP> S <SEP> C1 <SEP> H <tb> 02K5 <SEP> CH3 <SEP> CH3 <SEP> O <SEP> NO2 <SEP> H <tb> C2H3 <SEP> CH3 <SEP> CH3 <SEP> O <SEP> Cl <SEP> H <tb> CH3 <SEP> CH3 <SEP> H <SEP> or- <SEP> H <tb> O2K5 <SEP> 02K5 <SEP> H <SEP> O <SEP> H <tb> 02H5 <SEP> CH3 <SEP> H <SEP> O <SEP> SO2N(CH3)2 <SEP> H <tb> CH3 <SEP> 02K5 <SEP> H <SEP> <SEP> SO2CH3 <tb> CH3 <SEP> C2H5 <SEP> CH3 <SEP> O <SEP> 522(CH2)C <SEP> 3 <tb> CH3 <SEP> 0 <SEP> 2H3 <SEP> H <SEP> = <SEP> N(-CH <SEP> ) <SEP> H <tb> Table 10 (continued) R1 R2 R3 w R14 R15 m.p.( C) C2H5 C2H5 CH3 O CO2C2H5 H C2H5 C2H5 H O OSO2CH3 H C2H5 C2H5 H O NO2 H C2H5 C2H5 H O Cl H CH3 C2H5 H O SO2N(CH3)C2H5 H CH3 C2H5 H O H 7-F CH3 C2H5 H O H 5-OCH3 CH3 C2H5 H O NO2 8-Cl CH3 CH3 H S CH3 H CH2CH=CH2 CH3 H O Cl H CH2C(CH3)=CH2 CH3 H O Cl H CH2C#CH CH3 H O NO2 H CH2C#CCH3 CH3 H O Br H CH3 CH2CH=CH2 H O OCH3 H CH3 CH2C(CH3)=CH2 H O NO2 H CH3 CH2C#CCH3 H O SO2CH3 H SCH3 CH3 CH3 O H H SCH3 CH3 CH3 O NO2 H SCH3 CH3 CH3 O Cl H SCH3 CH3 H O H H CH3 CH3 H O NO2 H CH3 CH3 H O Cl H SCH CH3 H O OCH3 H SCH3 CH3 H O CH3 H SCH3 CH3 H G F H SCH3 CH3 H S H H CH3 CH3 H O Cl H CH3 CH3 H O Na2 H CH3 C2H5 H O CH3 H CH3 C2H5 CH3 O NO2 H CH3 C2H5 CH3 O H H Table 10 (continued) R1 R2 R3 W R14 R15 m.p.( C) SCH3 C2H5 H O OSO2CHCl H SCH3 CH3 H O OSO2CH2CHFCl H SCH3 CH3 H O OSO2CH(CH3)CH2F H SCH3 CH3 H O OSO2(CH2)3Br H SCH3 CH3 H O OSO2(CH2)2CHCl H CH3 C2H5 H O OSO2CF3 H CH3 C2H5 H O OSO2CF2CH2F H C2H5 C2H5 H O OSO2CH2CF3 H SCH3 C2H5 H O OSO2CHF2 H CH3 C2H5 H O OSO2CCl3 H SC2H5 CH3 H O OSO2CH3 H SCH3 C2H5 H O NO2 4-Br SC2H5 CH3 H S H 5-OCH3 SCH3 CH3 CH3 O F 7-F S(CH2)2CH3 CH3 H O CH3 H SCH(CH3)2 CH3 H O SO2N(CH3)2 H SCH(CH3)C2H5 CH3 H O Br H SCHCH=CH2 CH3 H O Cl H SCHC(CH3)=CH2 CH3 H O Cl H SCHC#CCH3 CH3 H O NO2 H SCH2C02CH3 H O SO2C2H5 H SCH2CO2CH2CH3 CH3 H O Cl H SCH(CH3)C02CH3 CH3 H O Br H SCH(CH3)CO2C2H5 CH3 H O H H CH2OCH3 CH3 CH3 O H H CH2OCH3 CH3 H S H H CH2OCH3 CH3 H O NO2 H CH2OCH3 CH3 H O Cl H CH2OCH3 CH3 H O Br H CH2OCH3 CH3 H O OCH3 H CH2OCH3 CH3 H S H 6 CH2OCH3 CH3 H S H 3 Table 10 (continued) R1 R2 R3 w R14 R15 m.p.( C) CH2OCH3 C2H5 H O F H CH2OCH3 CH3 H O SO2C2H5 H CH2OCH3 CH3 H O SO2N(CH3)2 H CH2OCH3 CH3 H O OSO2C2H5 H CH2OC2H5 CH3 H O CH3 H CH2OC2H5 CH3 H O H H CH2O(CH2)3CH3 CH3 H O NO2 H CH2OCH(CH3)2 CH3 H O Cl H CH2CH2OCH3 CH3 H O H H CH2CH2OCH(CH3)2 CH3 H O OCH3 H OCH3 C2H5 H O H H OCH3 C2H5 H O H H OCH3 CH3 CH3 O H H OCH3 CH3 CH3 O Cl H OCH3 C2H5 H O SO2N(CH3)]CH(CH3)2] H OCH3 C2H5 H O SO2N(CH3)[(CH2)2CH3] H OCH3 C2H5 H O SO2N(CH3)2 H OCH3 CH3 H O OSO2(CH2)2CHCl2 H OCH3 CH3 H O OSO2CH(CH3)CHF2 H OCH3 CH3 H O OSO2CHFCF3 H OC2H5 CH3 H O Br H OC2H5 CH3 H O Cl 4-Cl OC2H5 CH3 H O H 8-NO2 OC2H5 CH3 H S H H OC2H5 CH3 H S NO2 H OC2H5 CH3 H O SCH3 H OC2H5 CH3 H O SCH2CH(CH3)2 H OC2H5 CH3 H O S(CH2)3CH3 H OCH3 C2H5 H O S(CH2)2CH3 H OCH3 C2H5 H O SC2H5 H OCH3 C2H5 H O SO2CH2CH(CH3)2 H Table 10 (continued) R1 R2 R3 w R14 R15 m.p. ( C) OCH3 C2H5 H O SO2CH(CH3)2 H OCH3 C2H5 H O SO2CH3 H OCH3 C2H5 H O SO2(CH2)2CH3 H O(CH2)2CH3 CH3 H O SO2N(CH3)2 H OCH(CH3)2 CH3 H O CH3 H OCH(CH3)C2H5 CH3 H O OCH3 H OCH2CH=CH2 CH3 H O H H OCH2C(CH3)=CH2 CH3 H O Cl H OCH2C#CCH3 CH3 H O NO2 H N(CH3)2 CH3 H O H H N(CH3)2 CH3 H O Cl H CF3 CH3 H O Cl H CF3 CH3 H O NO2 H CF3 CH3 H S Cl H CF3 C2H5 H O H H CF3 C2H5 H O F H CF3 C2H5 H O SO2CH(CH3)2 H CF3 C2H5 H O OSO2C2H5 H CF3 C2H5 H O OSO2CH(CH3)2 H CF2CF3 CH3 H O OSO2CH3 H CF2CF3 CH3 H O OSO2CH2CH2Cl H CF2CF3 CH3 H O NO2 H CF2CF3 C2H5 H O Cl H CF3 CH2OCH3 H O Br H CF3 CH2OCH3 H O NO2 H CF3 CH2OCH(CH3)2 H O Br H CF3 CH2CH2OCH3 H O NO2 H CF3 CH2cH2S(CH2)2CH3 H O Cl H CF3 CH2CH2SCH3 H O H H CF3 CH2SCH3 H O CH3 H CF3 CH2CH2SCH3 H O OCH3 H CF3 CH2OC2H5 H O F H Table 10 (continued) R1 R2 R3 W R14 R15 m.p.( C) OCH3 C2H5 H O OSO2CH2CH2OCH3 H OC2H3 CH3 H O OSO2(CH2)3OCH3 H SCH3 CH3 H O OSO2(CH2)3CH3 H SCH3 CH3 H S Br H SCH3 CH3 H O Br 8-Cl SCH3 CH3 H O H 3-OCH3 SCH3 CH3 H O H 6-Br SCH3 CH3 CH3 O SO2CH3 H SCH3 CH3 CH3 O SO2C2H5 H OC2H5 CH3 CH3 O Cl H OC2H5 CH3 CH3 O NO2 H SC2H5 CH3 H O F H C2H5 C2H5 CH3 O H H SCH3 CH3 H S Cl H OC2H5 CH3 H O OSO2CH2Cl H OC2H5 CH3 H O SO2CH3 H OC2H5 CH3 H O SO2(CH2)2CH3 H OC2H5 CH3 H O SCH2CH3 H OC2H5 CH3 H O OSO2CF3 H OC2H5 CH3 H O SO2N(CH3)[(CH2)2CH3] H OC2H5 CH3 H O CH3 H OC2H5 CH3 H O OCH3 H OC2H5 CH3 H O F H OC2H5 CH3 H O Cl H OC2H5 CH3 H O NO2 H OC2H5 CH3 H O SO2N(CH3)2 H OC2H5 CH3 H O SO2N(C2H5)2 H OC2H5 CH3 H O SO2N(OCH3)CH3 H OC2H5 CH3 H O OSO2CH3 H OC2H5 CH3 H O OSO2(CH2)3CH3 H OC2H5 CH3 H O SO2CH2CH=CH2 H Table 10 (continued) R1 R2 R3 W R14 R15 m.p.( C) OC2H5 CH3 H O SO2CF3 H OC2H5 CH3 H O SO2CF2CF3 H OCH3 CH3 H O H H OCH3 CH3 H O CH3 H OCH3 CH3 H O OCH3 H OCH3 CH3 H O F H OCH3 CH3 H O Cl H OCH3 CH3 H O Br H OCH3 CH3 H O NO2 H OCH3 CH3 H O SO2N(CH3)2 H OCH3 CH3 H O SO2N(C2H5)2 H OCH3 CH3 H O SO2N(CH3)C2H5 H OCH3 CH3 H O SO2N(OCH3)CH3 H OCH3 CH3 H O OSO2CH3 H OCH3 CH3 H O OSO2C2H5 H OCH3 CH3 H O OSO2CF3 H OCH3 CH3 H O SCH3 H OCH3 CH3 H O SOCH3 H OCH3 CH3 H O SO2CH3 H OCH3 CH3 H O SC2H5 H OCH3 CH3 H O SO2C2H5 H OCH3 CH3 H O SO2CH2CH2CH3 H OCH3 CH3 H O SO2CH2CH=CH2 H OCH3 CH3 H O SO2CF3 H OCH3 CH3 H O SO2CH2CF3 H OCH3 CH3 H O SO2CH2CHClCF3 H OCH3 CH2CF3 H O CH3 H OCH3 CH2CF3 H O OCH3 H OCH3 CH2CF3 H O Cl H OCH3 CH2CF3 H O NO2 H OCH3 CH2CF3 H O SO2N(CH3)2 H Table 10 (continued) EMI138.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R14 <SEP> R15 <SEP> m.P.( O) <tb> OCH3 <SEP> 2 <SEP> K <SEP> O <SEP> SO2N(OCH3)CH3 <SEP> H <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> OS02CH3 <SEP> H <tb> 0CK3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> OS02CF3 <SEP> H <tb> OCH3 <SEP> CH2CF3 <SEP> H <SEP> O <SEP> S02CH3 <SEP> K <tb> OCH3 <SEP> C <SEP> CF3 <SEP> H <SEP> O <SEP> SO2CH2CH2CH3 <SEP> H <tb> OCH3 <SEP> 2CF3 <SEP> H <SEP> O <SEP> S020K20H=OK2 <SEP> K <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> Cl <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> NO2 <SEP> H <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> S02N(CK3)2 <SEP> H <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> OS02CH3 <SEP> H <tb> C1 <SEP> CH3 <SEP> K <SEP> 0 <SEP> S02CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> - <SEP> CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> Br <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> S02N(GOK3)0K3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> OS02CF3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> 502CH2CH3 <SEP> H <tb> NHCH3 <SEP> CH3 <SEP> K <SEP> O <SEP> S02OH2OK=0H2 <SEP> K <tb> CH(OSH3)Z <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <SEP> H <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> F <SEP> H <tb> OH(oO)2 <SEP> OK3 <SEP> H <SEP> O <SEP> NO2 <SEP> H <tb> ( <SEP> 3)2 <SEP> C <SEP> 3 <SEP> H <SEP> O <SEP> SO2N(C2H5)2 <SEP> H <tb> C <SEP> (OCH3)2 <SEP> CH3 <SEP> H <SEP> 0 <SEP> S02CH3 <SEP> H <tb> <SEP> /08 <tb> CYO <SEP> j <SEP> CH3 <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> /om <tb> C\HO <SEP> g <SEP> CH3 <SEP> H <SEP> O <SEP> CH3 <tb> <SEP> Oo <tb> OK3 <SEP> H <SEP> CH, <SEP> H <SEP> O <SEP> OCH3 <SEP> H <tb> <SEP> /0 > <tb> rf <SEP> u <SEP> ¯ <SEP> ; ;1 <tb> Table 10 (continued) EMI139.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R14 <SEP> R15 <SEP> m.p.(00) <tb> <SEP> 0 <tb> o <SEP> OK3 <SEP> K <SEP> 0 <SEP> Cl <SEP> K <tb> c/nol <tb> CH <SEP> CH3 <SEP> H <SEP> O <SEP> Br <SEP> H <tb> <SEP> /0E <tb> C\HO <SEP> j <SEP> CH3 <SEP> H <SEP> <SEP> NO2 <SEP> H <tb> / <SEP> 3 <SEP> K <SEP> O <SEP> SO2N(CH3)2 <SEP> H <tb> CK3 <SEP> K <SEP> CH3 <SEP> O <SEP> <SEP> SO2N(OCH3)CH3 <SEP> H <tb> CH <SEP> 3 <SEP> CH3 <SEP> H <SEP> O <SEP> OSO2CH3 <SEP> H <tb> <SEP> /0E <tb> C\HO <SEP> g <SEP> CH3 <SEP> H <SEP> O <SEP> OSO2CF3 <SEP> H <tb> <SEP> \0I <tb> CH3 <SEP> H <SEP> O <SEP> SCH <SEP> ti <tb> <SEP> OK3 <SEP> K <SEP> 0 <SEP> SOK3 <SEP> K <tb> OK0 <SEP> 2 <SEP> CH3 <SEP> H <SEP> O <SEP> S02C2H5 <SEP> - <SEP> H <tb> c'HO <SEP> CH3 <SEP> H <SEP> O <SEP> SO2CH2CH=CHÇ <SEP> H <tb> CH <SEP> 2 <SEP> CH3 <SEP> K <SEP> <SEP> SO2CH2C <SEP> 2CA3 <SEP> H <tb> <SEP> /0 > <tb> o$00J <SEP> CH3 <SEP> K <SEP> 0 <SEP> S020K3 <SEP> H <tb> Table 11 EMI140.1 R1 R2 R3 W R19 m.p.( C) OCH3 CH3 H O Cl OCH3 CH3 H O NO2 OCH3 CH3 H O CF3 OCH3 CH3 H O CO2CH3 164-166 OCH3 CH3 H O CO2C2H5 OCH3 CH3 H O CO2(CH2)2CH3 OCH3 CH3 H O CO2(CH2)3CH3 OCH3 CH3 H O CO2(CH2)4CH3 OCH3 CH3 H O CO2(CH2)5CH3 OCH3 CH3 H O CO2CH(CH3)2 OCH3 CH3 H O CO2CH2CH2OCH3 OCH3 CH3 H O CO2CH2CH2OC2H5 OCH3 CH3 H O CO2(CH2)3OC2H5 OCH3 CH3 H O CO2CH2CH=CH2 OCH3 CH3 H O CO2CH2CH=CHCH3 OCH3 CH3 H O CO2(CH2)4CH=CH2 OCH3 CH3 H O CO2CH2C#CH OCH3 CH3 H O CO2CH2C#CCH3 OCH3 CH3 H O CO2(CH2)4C#CH OCH3 CH3 H O CO2CH(CH3)C2H5 OCH3 CH3 H O CO2CH2CH(CH3)2 OCH3 CH3 H O CO2CF3 OCH3 CH3 H O CO2CH2CH2Cl OCH3 CH3 H O CO2CH2CF3 Table 11 (continued) R1 R2 R3 W R19 OCH3 CH3 H O CO2CH2CCl3 OCH3 CH3 H O CO2CH2CH2CF3 OCH3 CH3 H O CO2CH2CH2CH2Cl OCH3 CH3 H O CO2CClF2 OCH3 CH3 H O CO2CF2H OCH3 CH3 H O CO2CHFCF2H OCH3 CH3 H O CO2CHClCF2H OCH3 CH3 H O CO2CH2CHFCF2H OCH3 CH3 H O SO2N(OCH3)CH3 OCH3 CH3 H O SO2N(CH3)2 OCH3 CH3 H O SO2N(C2H5)2 OCH3 CH3 H O SO2N(CH3)C2H5 OCH3 CH3 H O SO2N(CH3)CH2CH2CH3 OCH3 CH3 H O OSO2CH3 OCH3 CH3 H O OSO2C2H5 OCH3 CH3 H O OSO2(CH2)2CH3 OCH3 CH3 H O OSO2(CH2)3CH3 OCH3 CH3 H O OSO2CH(CH3)2 OCH3 CH3 H O OSO2CH(CH3)C2H5 OCH3 CH3 H O OSO2CH2CH2OCH3 OCH3 CH3 H O OSO2(CH2)3OCH3 OCH3 CH3 H O OSO2OF3 OCH3 CH3 H O OSO2CH2CF3 OCH3 CH3 H O OS02CHFCF2H OCH3 OH3 H O OSO2CF2CH2CH2CH3 OCH3 CH3 H O OS02CC1F2 OCH3 CH3 H O OSO2CBr2CH3 OCH3 CH3 H O N(CH3)SO2CH3 OCH3 CH3 H O N(CH3)SO2C2H5 OCH3 CH3 H O N(CH3)SO2C3H5 OCH3 CH3 H O N(CH3)SO2CH(CH3)C2H3 Table II (continued) R1 R2 R3 W R19 m.p.( C) OCH3 CH3 H O N(CH3)SO2 CH2CH2OCH3 OCH3 CH3 H O N(CH3)SO2CF3 OCH3 CH3 H O SCH3 OCH3 CH3 H O SOCH3 OCH3 CH3 H O SO2CH3 OCH3 CH3 H O SO2C2H5 OCH3 CH3 H O SO2CH2CH2CH3 OCH3 CH3 H O SO2CH(CH3)2 OCH3 CH3 H O SO2CH2CH=CH2 OCH3 CH3 H O SO2CH(CH3)C2H5 OCH3 CH3 H O SCH2CH2CH3 OCH3 CH3 H O SCF3 OCH3 CH3 H O SOCF3 OCH3 CH3 H O SO2CF3 OCH3 CH3 H O OCCl3 OCH3 CH3 H O OCF3 OCH3 CH3 H O OCF2CF3 OCH3 CH3 H O OCF2CF2CH3 OCH3 CH3 H O OCClF2 OCH3 CH3 H O OCCl2CF3 OC2H5 CH3 H O Cl OC2H5 CH3 H O NO2 OC2H5 CH3 H O CF3 OC2H5 CH3 H O CO2CH3 OC2H5 CH3 H O CO2C2H5 OC2H5 CH3 H O CO2CH2CH2CH3 OC2H5 CH3 H O CO2CH(CH3)2 OC2H5 CH3 H O CO2CH2CH=CH2 OC2H5 CH3 H O CO2CH2C#CH OC2H5 CH3 H O CO2CH2CH2OCH3 OC2H5 CH3 H O CO2CH2CH2OC2H5 Table 11 (continued) R1 R2 R3 W R19 m.p.( C) OC2H5 CH3 H O CO2CF3 OC2H5 CH3 H O SO2N(OCH3)CH3 OC2H5 CH3 H O SO2N(CH3)2 OC2H5 CH3 H O SO2N(CH3)C2H5 OC2H5 CH3 H O SO2N(C2H5)2 OC2H5 CH3 H O OSO2CH3 OC2H5 CH3 H O OSO2C2H5 OC2H5 CH3 H O N(CH3)SO2CH3 OC2H5 CH3 H O SO2CH3 OC2H5 CH3 H O SO2C2H5 OC2H5 CH3 H O SO2CH2CH2CH3 OC2H5 CH3 H O SO2CHCH=CH2 OC2H5 CH3 H O SO2CF3 OC2H5 CH3 H O OCF3 OC2H5 CH3 H O OCF2CF3 OC2H5 C2H5 H O Cl OC2H5 C2H5 H O NO2 OC2H5 C2H5 H O CF3 OC2H5 C2H5 H O CO2CH3 OC2H5 C2H5 H O CO2C2H5 OC2H5 C2H5 H O CO2CH2CH2CH3 OC2H5 C2H5 H O CO2CH(CH3)2 OC2H5 C2H5 H O CO2CHCH=CH2 OC2H5 C2H5 H O CO2CH2=C#CH OC2H5 C2H5 H O CO2CH2CH2OCH3 OC2H5 C2H5 H O SO2N(OCH3)CH3 OC2H5 C2H5 H O SO2N(CH3)2 OC2H5 C2H5 H O OSO2CH3 OC2H5 C2H5 H O N(CH3)SO2CH3 OC2H5 C2H5 H O SO2CH3 OC2H5 C2H5 H O SO2CH2CH3 Table II (continued) R1 R2 R3 W R19 m.p.( C) OC2H5 C2H5 H O SO2CH2CH2CH3 OC2H5 C2H5 H O OCF3 OCH2CH2CH3 CH3 H O Cl OCH2CH2CH3 CH3 H O NO2 OCH2CH2CH3 CH3 H O CF3 OCH2CH2CH3 CH3 H O CO2CH3 OCH2CH2CH3 CH3 H O CO2CH2CH=CH2 OCH2CH2CH3 CH3 H O SO2N(OCH3)CH3 OCH2CH2CH3 CH3 H O SO2N(CH3)2 OCH2CH2CH3 CH3 H O OSO2CH3 OCH2CH2CH3 CH3 H O N(CH3)SO2CH3 OCH2CH2CH3 CH3 H O SO2CH3 OCH2CH2CH3 CH3 H O SO2CH2CH2CH3 OCH2CH2CH3 CH3 H O OCF3 O(CH2)3CH3 CH3 H O Cl O(CH2)3CH3 CH3 H O NO2 O(CH2)3CH3 CH3 H O CF3 O(CH2)3CH3 CH3 H O CO2CH3 O(CH2)3CH3 CH3 H O CO2C2H5 O(CH2)3CH3 CH3 H O CO2CH(CH3)2 O(CH2)3CH3 CH3 H O SO2N(CH3)2 O(CH2)3CH3 CH3 H O SO2CH3 O(CH2)3CH3 CH3 H O SO2CH2CH2CH3 O(CH2)3CH3 CH3 H O OCF3 OCH3 C2H5 H O Cl OCH3 C2H5 H O NO2 OCH3 C2H5 H O CF3 OCH3 C2H5 H O CO2CH3 OCH3 C2H5 H O CO2C2H5 OCH3 C2H5 H O CO2CH(CH3)2 OCH3 C2H5 H O CO2CH2CH=CH2 Table II (continued) R1 R2 R3 W R19 m.p.( C) OCH3 C2H5 H O CO2CH2CH2OCH3 OCH3 C2H5 H O CO2CH2CH2Cl OCH3 C2H5 H O SO2N(OCH3)CH3 OCH3 C2H5 H O SO2N(CH3)2 OCH3 C2H5 H O OSO2CH3 OCH3 C2H5 H O N(CH3)SO2CH3 OCH3 C2H5 H O SO2CH3 OCH3 C2H5 H O SO2CH2CH2CH3 OCH3 C2H5 H O OCF3 OCH3 CH2CH=CH2 H O Cl OCH3 CH2CH=CH2 H O NO2 OCH3 CH2CH=CH2 H O CF3 OCH3 CH2CH=CH2 H O CO2CH3 OCH3 CH2CH=CH2 H O CO2C2H5 OCH3 CH2CH=CH2 H O CO2CH(CH3)2 OCH3 CH2CH=CH2 H O CO2CH2CH=CH2 OCH3 CH2CH=CH2 H O CO2CH2CH2OCH3 OCH3 CH2CH=CH2 H O SO2N(Me)2 OCH3 CH2CH=CH2 H O OSO2CH3 OCH3 CH2CH=CH2 H O SO2CH3 OCH3 CH2CH=CH2 H O SO2CH2CH2CH3 OCH3 CH2CH=CH2 H O OCF3 OCH3 CH2OCH3 H O Cl OCH3 CH2OCH3 H O NO2 OCH3 CH2OCH3 H O CO2CH3 OCH3 CH2OCH3 H O CO2CH2CH2CH3 OCH3 CH2OCH3 H O CO2CH2CH=CH2 OCH3 CH2OCH3 H O SO2N(Me)2 OCH3 CH2OCH3 H O SO2CH3 OCH3 CH2OCH3 H O SO2CH2CH2CH3 OCH3 CH2OCH3 H O OSO2CH3 Table II (continued) R1 R2 R3 W R19 m.p.( C) OCH3 CH2OCH3 H O OCF3 OCH3 CH2SCH3 H O Cl OCH3 CH2SCH3 H O NO2 OCH3 CH2SCH3 H O CO2CH3 OCH3 CH2SCH3 H O CO2CH2CH3 OCH3 CH2SCH3 H O CO2CH(CH3)2 OCH3 CH2SCH3 H O CO2CH2CH=CH2 OCH3 CH2SCH3 H O SO2N(CH3)2 OCH3 CH2SCH3 H O OSO2CH3 OCH3 CH2SCH3 H O SO2CH3 OCH3 CH2SCH3 H O SO2CH2CH2CH3 OCH3 CH2SCH3 H O OCF3 OCH3 CH2CF3 H O Cl OCH3 CH2CF3 H O NO2 OCH3 CH2CF3 H O CF3 OCH3 CH2CF3 H O CO2CH3 OCH3 CH2CF3 H O CO2CH2CH=CH2 OCH3 CH2CF3 H O OSO2CH3 OCH3 CH2CF3 H O SO2CH3 OCH3 CH2CF3 H O SO2CH2CH2CH3 OCH3 CH2CF3 H O SO2N(CH3)2 OCH3 CH2C#CH H O CO2CH3 OCH3 CH2CH2OCH3 H O CO2CH3 OCH3 CH2CH2SCH3 H O CO2CH3 OCH3 CH2CH2CH3 H O CO2CH3 CH3 CH3 H O Cl CH3 CH3 H O NO2 CH3 CH3 H O CF3 CH3 CH3 H O CO2CH3 CH3 CH3 H O CO2CH2CH=CH2 CH3 CH3 H O SO2N(CH23)2 Table 11 (continued) EMI147.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> R19 <SEP> m.P.( C) <tb> CH3 <SEP> CH3 <SEP> K <SEP> O <SEP> S02CH3 <tb> C2K5 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> (CH2)3CH3 <SEP> K <SEP> O <SEP> 002OK3 <tb> CH2CH=CH2 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> CK2C=OK <SEP> CH3 <SEP> H <SEP> O <SEP> 002OK3 <tb> SCH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> SCH2C <SEP> 3 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> SCH2CH=CH2 <SEP> H <SEP> O <SEP> 2 <SEP> 3 <tb> SCH2C02CH3 <SEP> CH3 <SEP> H <SEP> 0 <SEP> C02C <SEP> 3 <tb> CH20CH3 <SEP> OK3 <SEP> K <SEP> O <SEP> C 2CH3 <tb> CH20CH2CH3 <SEP> O <SEP> C 2C <SEP> 3 <tb> CH2CH20CH3 <SEP> OK3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> N(CH3)2 <SEP> CH3 <SEP> K <SEP> O <SEP> C 2CH3 <tb> CF3 <SEP> CH3 <SEP> H <SEP> O <SEP> CS2CH3 <tb> CF2CF3 <SEP> OK3 <SEP> K <SEP> O <SEP> 002OK3 <tb> Cl <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <tb> NH(CH3) <SEP> OK3 <SEP> K <SEP> O <SEP> C 2 <SEP> 3 <tb> CH(OCH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> 0K0 <SEP> S <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <tb> OCH3 <SEP> CH3 <SEP> CH3 <SEP> 0 <SEP> C 2CH3 <tb> OCH3 <SEP> CH3 <SEP> H <SEP> S <SEP> C 2CH3 <tb> OCH3 <SEP> C <SEP> H <SEP> S <SEP> S02N(CH3)2 <tb> OCH3 <SEP> 3 <SEP> CH3 <SEP> 0 <SEP> 502N(CH3)2 <tb> Table 12 EMI148.1 R1 R2 R3 W R19 m.p.( C) OCH3 CH3 H O Cl OCH3 CH3 H O NO2 OCH3 CH3 H O CF3 OCH3 CH3 H O CO2CH3 OCH3 CH3 H O CO2C2H5 OCH3 CH3 H O CO2(CH2)2CH3 OCH3 CH3 H 0 CO2(CH2)3CH3 OCH3 CH3 H O CO2(CH2)4CH3 OCH3 CH3 H O CO2(CH2)5CH3 OCH3 CH3 H O CO2CH(CH3)2 OCH3 CH3 H O CO2CH2CH2OCH3 OCH3 CH3 H O CO2CH2CH2OC2H5 OCH3 CH3 H O CO2(CH2)3OC2H5 OCH3 CH3 H O CO2CH2CH=CH2 OCH3 CH3 H O CO2CH2CH=CHCH3 OCH3 CH3 H O CO2(CH2)4CH=CH2 OCH3 CH3 H O CO2CH2C#CH OCH3 CH3 H O CO2CH2#CCH3 OCH3 CH3 H O CO2(CH2)4C#CH OCH3 CH3 H O CO2CH(CH3)C2H5 OCH3 CH3 H O CO2CH2CH(CH3)2 OCH3 CH3 H O CO2CF3 OCH3 CH3 H O CO2CH2CH2Cl OCH3 CH3 H O CO2CH2CF3 Table 12 (continued) R1 R2 R3 W R19 m.p.( C) OCH3 CH3 H O CO2CH2CCl3 OCH3 CH3 H O CO2CH2CH2CF3 OCH3 CH3 H O CO2CH2CH2CH2Cl OCH3 CH3 H O C02CC1F2 OCH3 CH3 H O CO2CF2H OCH3 CH3 H O CO2CHFCF2H OCH3 CH3 H O CO2CH1CF2H OCH3 CH3 H O CO2CH2CHFCF2H OCH3 CH3 H O SO2N(OCH3)CH3 OCH3 CH3 H O SO2N(CH3)2 OCH3 CH3 H O SO2N(C2H5)2 OCH3 CH3 H O SO2N(CH3)C2H5 OCH3 CH3 H O SO2N(CH3)CH2CH2CH3 OCH3 CH3 H O OSO2CH3 OCH3 CH3 H O OSO2C2H5 OCH3 CH3 H O OS02(CH2)2CH3 OCH3 CH3 H O OSO2(CH2)3CH3 OCH3 CH3 H O OSO2CH(CH3)2 OCH3 CH3 H O OS02CH(CH3)C2H5 OCH3 CH3 H O OSO2CH2CH2OCH3 OCH3 CH3 H O OSO2(CH2)3OCH3 OCH3 CH3 H O OSO2CF3 OCH3 CH3 H O OSO2CH2CF3 OCH3 CH3 H O OSO2CHFCF2H OCH3 CH3 H O OSO2CF2CH2CH2CH3 OCH3 CH3 H O OSO2CClF2 OCH3 CH3 H O OSO2CBr2CH3 OCH3 CH3 H O N(CH3)SO2CH3 OCH3 CH3 H O N(CH3)SO2C2H5 OCH3 CH3 H O N(CH3)SO2C3H5 OCH3 CH3 H O N(CH3)SO2CH(CH3)C2H5 Table 12 (continued) R1 R2 R3 W R19 m.p.( C) OCH3 CH3 H O N(CH3)SO2CH2CH2OCH3 OCH3 CH3 H O N(CH3)SO2CF3 OCH3 CH3 H O SCH3 OCH3 CH3 H O SOCH3 OCH3 CH3 H O SO2CH3 OCH3 CH3 H O SO2C2H5 OCH3 CH3 H O SO2CH2CH2CH3 OCH3 CH3 H O SO2CH(CH3)2 OCH3 CH3 H O SO2CH2CH=CH2 OCH3 CH3 H O SO2CH(CH3)C2H5 OCH3 CH3 H O SCH2CH2CH3 OCH3 CH3 H O SCF3 OCH3 CH3 H O SOCF3 OCH3 CH3 H O SO2CF3 OCH3 CH3 H O OCCl3 OCH3 CH3 H O OCF3 OCH3 CH3 H O OCF2CF3 OCH3 CH3 H O OCF2CF2CH3 OCH3 CH3 H O OCClF2 OCH3 CH3 H O OCCl2CF3 OC2H5 CH3 H O Cl OC2H5 CH3 H O NO2 OC2H5 CH3 H O CF3 OC2H5 CH3 H O CO2CH3 OC2H5 CH3 H O CO2C2H5 OC2H5 CH3 H O CO2CH2CH2CH3 OC2H5 CH3 H O CO2CH(CH3)2 OC2H5 CH3 H O CO2CH2CH=CH2 OC2H5 CH3 H O CO2CH2C#CH OC2H5 CH3 H O CO2CH2CH2OCH3 OC2H5 CH3 H O CO2CH2CH2OC2H5 Table 12 (continued) R1 R2 R3 W R19 m.p.( C) OC2H5 CH3 H O CO2CF3 OC2H5 CH3 H O SO2N(OCH3)CH3 OC2H5 CH3 H O SO2N(CH3)2 OC2H5 CH3 H O SO2N(CH3)C2H5 OC2H5 CH3 H O SO2N(C2H5)2 OC2H5 CH3 H O OSO2CH3 OC2H5 CH3 H O OSO2C2H5 OC2H5 CH3 H O N(CH3)SO2CH3 OC2H5 CH3 H O SO2CH3 OC2H5 CH3 H O SOI2C2H5 OC2H5 CH3 H O SO2CH2CH2CH3 OC2H5 CH3 H O SO2CHCH=CH2 OC2H5 CH3 H O SO2CF3 OC2H5 CH3 H O OCF3 OC2H5 CH3 H O OCF2CF3 OC2H5 C2H5 H O Cl OC2H5 C2H5 H O NO2 OC2H5 C2H5 H O CF3 OC2H5 C2H5 H O CO2CH3 OC2H5 C2H5 H O CO2C2H5 OC2H5 C2H5 H O CO2CH2CH2CH3 OC2H5 C2H5 H O CO2CH(CH3)2 OC2H5 C2H5 H O CO2CHCH=CH2 OC2H5 C2H5 H O CO2CH2C#CH OC2H5 C2H5 H O CO2CH2CH2OCH3 OC2H5 C2H5 H O SO2N(OCH3)CH3 OC2H5 C2H5 H O SO2N(CH3)2 OC2H5 C2H5 H O OSO2CH3 OC2H5 C2H5 H O N(CH3)SO2CH3 OC2H5 C2H5 H O SO2CH3 OC2H5 C2H5 H O SO2CHCH3 Table 12 (continued) R1 R2 R3 W R19 m.p.( C) OC2H5 C2H5 H O SO2CH2CH2CH3 OC2H5 C2H5 H O OCF3 OCH2CH2CH3 CH3 H O Cl OCH2CH2CH3 CH3 H O NO2 OCH2CH2CH3 CH3 H O CF3 OCH2CH2CH3 CH3 H O CO2CH3 OCH2CH2CH3 CH3 H O CO2CH2CH=CH2 OCH2CH2CH3 CH3 H O SO2N(OCH3)CH3 OCH2CH2CH3 CH3 H O SO2N(CH3)2 OCH2CH2CH3 CH3 H O OSO2CH3 OCH2CH2CH3 CH3 H O N(CH3)SO2CH3 OCH2CH2CH3 CH3 H O SO2CH3 OCH2CH2CH3 CH3 H O SO2CH2CH2CH3 OCH2CH2CH3 CH3 H O OCF3 O(CH2)3CH3 CH3 H O Cl O(CH2)3CH3 CH3 H O NO2 O(CH2)3CH3 CH3 H O CF3 O(CH2)3CH3 CH3 H O CO2CH3 O(CH2)3CH3 CH3 H O CO2C2H5 O(CH2)3CH3 CH3 H O CO2CH(CH3)2 O(CH2)3CH3 CH3 H O SO2N(CH3)2 O(CH2)3CH3 CH3 H O SO2CH3 O(CH2)3CH3 CH3 H O SO2CH2CH2CH3 O(CH2)3CH3 CH3 H O OCF3 OCH3 C2H5 H O Cl OCH3 C2H5 H O NO2 OCH3 C2H5 H O CF3 OCH3 C2H5 H O CO2CH3 OCH3 C2H5 H O CO2C2H3 OCH3 C2H5 H O CO2CH(CH3)2 OCH3 C2H5 H O CO2CH2CH=CH2 Table 12 (continued) R1 R2 R3 w R19 m.p.( C) OCH3 C2H5 H O CO2CH2CH2OCH3 OCH3 C2H5 H O CO2CH2CH2Cl OCH3 C2H5 H O SO2N(OCH3)CH3 OCH3 C2H5 H O SO2N(CH3)2 OCH3 C2H5 H O OSO2CH3 OCH3 C2H5 H O N(CH3)SO2CH3 OCH3 C2H5 H O SO2CH3 OCH3 C2H5 H O SO2CH2CH2CH3 OCH3 C2H5 H O OCF3 OCH3 CH2CH=CH2 H O CL OCH3 CH2CH=CH2 H O NO2 OCH3 CH2CH=CH2 H O CF3 OCH3 CH2CH=CH2 H O CO2CH3 OCH3 CH2CH=CH2 H O CO2C2H5 OCH3 CH2CH=CH2 H O CO2CH(CH3)2 OCH3 CH2CH=CH2 H O CO2CH2CH=CH2 OCH3 CH2CH=CH2 H O CO2CH2CH2OCH3 OCH3 CH2CH=CH2 H O SO2N(Me)2 OCH3 CH2CH=CH2 H O OSO2CH3 OCH3 CH2CH=CH2 H O SO2CH3 OCH3 CH2CH=CH2 H O SO2CH2CH2CH3 OCH3 CH2CH=CH2 H O OCF3 OCH3 CH2OCH3 H O Cl OCH3 CH2OCH3 H O NO2 OCH3 CH2OCH3 H O CO2CH3 OCH3 CH2OCH3 H O CO2CH2CH2CH3 OCH3 CH2OCH3 H O CO2CH2CH=CH2 OCH3 CH2OCH3 H O SO2N(Me)2 OCH3 CH2OCH3 H O SO2CH3 OCH3 CH2OCH3 H O SO2CH2CH2CH3 OCH3 CH2OCH3 H O OSO2CH3 Table 12 (continued) R1 R2 R3 w R19 m.p.( C) OCH3 CH2OCH3 H O OCF3 OCH3 CH2OCH3 H O CL OCH3 CH2OCH3 H O NO2 OCH3 CH2OCH3 H O CO2CH3 OCH3 CH2OCH3 H O CO2CH2CH3 OCH3 CH2OCH3 H O CO2CH(CH3)2 OCH3 CH2OCH3 H O CO2CH2CH=CH2 OCH3 CH2OCH3 H O SO2N(CH3)2 OCH3 CH2OCH3 H O OSO2CH3 OCH3 CH2OCH3 H O SO2CH3 OCH3 CH2OCH3 H O SO2CH2CH2CH3 OCH3 CH2OCH3 H O OCF3 OCH3 CH2OCH3 H O CL OCH3 CH2OCH3 H O NO2 OCH3 CH2OCH3 H O CF3 OCH3 CH2OCH3 H O CO2CH3 OCH3 CH2OCH3 H O CO2CH2CH=CH2 OCH3 CH2OCH3 H O OSO2CH3 OCH3 CH2OCH3 H O SO2CH3 OCH3 CH2OCH3 H O SO2CH2CH2CH3 OCH3 CH2OCH3 H O SO2N(CH3)2 OCH3 CH2OCH3 H O CO2CH3 OCH3 CH2OCH3 H O CO2CH3 OCH3 CH2OCH3 H O CO2CH3 OCH3 CH2OCH3 H O CO2CH3 CH3 CH3 H O CL CH3 CH3 H O NO2 CH3 CH3 H O CF3 CH3 CH3 H O CO2CH3 CH3 CH3 H O CO2CH2CH=CH2 CH3 CH3 H O SO2V(CH3)2 Table 12 (continued) EMI155.1 <tb> R1 <SEP> R2 <SEP> R3 <SEP> W <SEP> Rl9 <SEP> m.p.(oC) <tb> CH3 <SEP> CH3 <SEP> H <SEP> 0 <SEP> 502CM3 <tb> 02H5 <SEP> OK3 <SEP> K <SEP> O <SEP> C02CH3 <tb> (CH2)3CH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> CH2CH=CH2 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> CH2OlcK <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <tb> SCH3 <SEP> C <SEP> K <SEP> O <SEP> C02CH3 <tb> SOK2OK3 <SEP> OK3 <SEP> K <SEP> O <SEP> C 2CH3 <tb> SCH2CH=CH2 <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <tb> SCH2C02CH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> CH20CH3 <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <tb> CH20CH2CH3 <SEP> CH3 <SEP> H <SEP> O <SEP> cO2OK3 <tb> CH3 <SEP> CH3 <SEP> O <SEP> 002cm3 <tb> N(CH3)2 <SEP> CH3 <SEP> H <SEP> O <SEP> C02CH3 <tb> CF3 <SEP> OK3 <SEP> K <SEP> O <SEP> C 2CH3 <tb> CF2CF3 <SEP> CH3 <SEP> H <SEP> O <SEP> Q)2CH3 <tb> C1 <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> NH(CH3) <SEP> CH3 <SEP> K <SEP> 0 <SEP> a32CH3 <tb> CH(OCH3)2 <SEP> C <SEP> 3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> <SEP> JL <tb> CXHo <SEP> j <SEP> CH3 <SEP> H <SEP> O <SEP> C 2CH3 <tb> OCH3 <SEP> CH3 <SEP> CH3 <SEP> 0 <SEP> C 2CH3 <tb> OCH3 <SEP> OK3 <SEP> K <SEP> S <SEP> C 2CH3 <tb> OCH3 <SEP> OK3 <SEP> K <SEP> S <SEP> 502N(CH3)2 <tb> OCH3 <SEP> CH3 <SEP> CH3 <SEP> 0 <SEP> 502N(CH3)2 <tb> Table 13 EMI156.1 R' R1' R2' R7' R8 m.p.( C) CH3CH2 H C2H5 CO2C2H5 H H CH3 C2H5 SO2CH3 H CH3 CH3 C2H5 CF3 H H CH3 C2H5 Br H CH3 CH3 C2H5 Cl H H CH3 C2H5 CH3 H CH3 CH3 C2H5 C2H5 H H CH3 C2H5 NO2 H CH3 CH3 C2H5 SO2(CH2)2CH3 H H CH3 C2H5 SO2N(CH3)2 H CH3 CH3 C2H5 NO2 H H CH3 C2H5 OCH3 H CH3 OCH3 C2H5 CO2CH(CH3)2 H H OCH3 C2H5 CO2CH2CH=CH2 H CH3 OCH3 C2H5 OCF2CF2H H H OCH3 C2H5 CH2OCH3 H CH3 OCH3 C2H5 OSO2CHCl H H OH3 C2H5 CF3 H CH3 OH3 C2H5 SC2H5 H H OCH3 C2H5 OSO2C2H5 H H CH3 C2H5 CO2CH2CH2Cl H CH3 OCH3 C2H5 OSO2CH2CH2OCH3 H H OC2H5 CH3 SO2N(OCH3)CH3 H H C2H5 CH3 CO2CH3 H H C2H5 CH3 Br H Table 13 (continued) R R1' R2' R7' R8 m.p.( C) H C2H5 CH3 NO2 H H C2H5 CH3 C 2CH3 H H C2H5 CH3 SO2CH3 H H OC2H5 CH3 CO2CH2CH2OCH3 H H OC2H5 CH3 SO2CH2(CH2)2OCH3 H H C2H5 CH3 CH3 H H C2H5 CH3 Cl H H C2H5 CH3 CH3 H H 02H5 CH3 C02CH(CH3)2 H H C2H5 CH3 Cl H H C2H5 CH3 CO2CH2CH=CH2 H H OC2H5 CH3 OSO2CH2CF2H H H OC2H5 CH3 OSO2CCL3 H H OC2H5 CH3 OSO2CHCl2 H H C2H5 CH3 OSO2CH3 H H C2H5 CH3 CH2OC2H5 H H C2H5 CH3 SO2C2H5 H H OC2H5 CH3 OSO2CF3 H H C2H5 CH3 OCF3 H H OC2H5 CH3 OCH3 H H C2H5 CH3 NO2 5-CF3 H C2H5 CH3 NO2 3-Cl H C2H5 CH3 Cl 6-NO2 H C2H5 CH3 CF3 5-NO2 H CH3 C2H5 Cl 5-Cl H OCH3 C2H5 NO2 5-Cl CH3 CH3 C2H5 SO2N(CH3)2 3-Cl CH3 OC2H5 CH3 CO2CH3 5-C2H CH3 C2H5 CH3 Cl 3-Br CH3 OC2H5 CH3 Cl 5-Br CH3 C2H5 CH3 NO2 6-F CH3 OC2H5 CH3 Cl 5-F Table 13 (continued) R' R1' R2' R7 R8 m.p. ( C) CH3 OC2H5 CH3 Br 3-F CH3 C2H5 CH3 NO2 5-NO2 CH3 C2H5 CH3 CO2CH3 3-CF3 CH3 OC2H5 CH3 CH3 3-NO2 CH3 C2H5 C2H5 CO2CH3 H CH3 C2H5 CH3 CO2C2H5 H CH3 C2H5 C2H5 Cl H CH3 C2H5 C2H5 NO2 H CH3 C2H5 C2H5 CH3 H CH3 C2H5 C2H5 CO2CH2CH=CH2 H CH3 C2H5 C2H5 CO2CH(CH3)2 H CH3 C2H5 C2H5 SO2CH3 H CH3 C2H5 C2H5 SO2(CH2)CH3 H CH3 OC2H5 C2H5 SO2CHF2 H CH3 C2H5 C2H5 SO2N(CH3)2 H CH3 C2H5 C2H5 SO2N(OCH3)CH3 H CH3 OC2H5 C2H5 OSO2CH3 H CH3 C2H5 C2H5 (CH2)2CH3 H CH3 C2H5 C2H5 OC2H5 H CH3 C2H5 C2H5 SCH3 H H SCH3 CH3 CO2CH3 H H SCH3 CH3 SO2CH3 H H SCH3 CH3 NO2 H H SCH3 CH3 SO2N(CH3)2 H H SCH3 CH3 SO2N(CH3)C2H5 H H SCH3 CH3 CH3 H H SCH3 CH3 NO2 H H SCH3 CH3 Cl H H SCH3 CH3 OSO2CH3 H H SCH3 CH3 CO2CH(CH3)2 H H SCH3 CH3 CO2CH2CH=CH2 H H SCH3 CH3 CO2CH2CH2Cl H Table 13 (continued) R R1' R2' R7' R8 m.p.( C) H SCH3 CH3 CO2CHCH2OCH3 H H SCH3 CH3 CO2CH(CH3)C2H5 H H SCH3 CH3 CO2(CH2)3 3 H H SCH3 CH3 OSO2(CH2)3CH3 H H SCH3 CH3 OSO2(CH2)3OCH3 H H SCH3 CH3 CH2OCH3 H H SCH3 CH3 OSO2CH2CF2H H H SCH3 CH3 F H H SCH3 CH3 OSO2CH2CCl H H SCH3 CH3 OSO2CH2CHCl H CH3 SCH3 CH3 OSO2CF3 H CH3 SCH3 CH3 OS02CHCl2 H CH3 SCH3 CH3 SO2(CH2)2CH3 H CH3 SCH3 CH3 SO2N(CH3)2 H CH3 SCH3 CH3 SO2N(C2H5)2 H CH3 SCH3 CH3 SO2N(CH3)[CH(CH3)2] H CH3 SCH3 CH3 SO2O(CH3)2 H CH3 SCH3 CH3 SO2O(CH2)3CH3 H CH3 SCH3 CH3 S02CH(CH3)2 H CH3 SCH3 CH3 CH2OC2H5 H CH3 SCH3 CH3 C2H5 H CH3 SCH3 CH3 CF3 H CH3 SCH3 CH3 Cl 5-Br CH3 SCH3 CH3 Cl 6-Cl CH3 SCH3 CH3 N02 5-Cl CH3 SCH3 CH3 CO2CH3 3-BR CH3 SCH3 CH3 Cl 5-NO2 CH3 SCH3 CH3 SO2N(CH3)2 5-NO2 CH3 SCH3 CH3 Cl 5-CH(CH3)2 CH3 SCH3 CH3 NO2 5-C2H5 CH3 SCH3 CH3 NO2 5-CF3 CH3 SCH3 CH3 NO2 3-CF3 Table 13 (continued) R R1' R2' R7' R8 m.p.( C) CH3 SCH3 CH3 SCF3 H CH3 SCH3 CH3 OCF3 H CH3 SCH3 CH3 NO2 6-F CH3 SCH3 CH3 Cl 5-OC2H5 CH3 SCH3 CH3 Br 5-NO2 CH3 SCH3 CH3 NO2 3-F CH3 SCH3 CH3 Cl 5-F CH3 SCH3 CH3 NO2 6-F H SCH3 CH3 OSO2CHF2 H H SCH3 CH3 OS02(CH2)3Br H H SCH3 C2H5 CO2CH3 H H SCH3 C2H5 Cl H H SCH3 C2H5 NO2 H H SCH3 C2H5 Br H H SCH3 C2H5 CH3 H H SCH3 C2H5 CF3 H H SCH3 C2H5 OCH3 H H SCH3 C2H5 CO2(CH2)2CH3 H H SCH3 C2H5 OSO2(CH2)2CH3 H H SCH3 C2H5 SO2N(CH3)C2H5 H H SCH3 C2H5 SO2N(OCH3)CH3 H H SCH3 C2H5 SO2(CH2)2CH3 H H SCH3 C2H5 OCHF2 H H SCH3 C2H5 CH(CH3)2 H CH3 SCH3 C2H5 SCF3 H CH3 SCH3 C2H5 OSO2(CH2)2OCH3 H CH3 SCH3 C2H5 SC2H5 H CH3 OCH3 CH3 Cl H CH3 OCH3 C2H5 NO2 H H OCH3 C2H5 CH3 H H OCH3 CH3 CF3 H H OCH3 CH3 Br H Table 13 (continued) R' R1' R2' R7' R8 m.p.( C) H OCH3 CH3 CO2CH3 H H OCH3 CH3 SO2CH3 H H OCH3 CH3 SCH3 H H OCH3 CH3 OSO2(CH2)3OCH3 H H OCH3 C2H5 OSO2CH2CHCl2 H H OCH3 C2H5 OSO2CH2CF2H H H OCH3 C2H5 OCF3 H H OCH3 C2H5 SCHF2 H H OCH3 C2H5 OSO2CH(CH3)2 H H OC2H5 CH3 F H H OC2H5 CH3 CO2CH3 3-Br H OC2H5 CH3 SO2CH3 H H OC2H5 CH3 S(CH2)3CH3 H H OC2H5 CH3 OSO2(CH2)3CH3 H H OC2H5 CH3 OCF3 H H OC2H5 CH3 SCF3 H H OC2H5 CH3 OCHF2 H H OC2H5 CH3 SCHF2 H H OC2H5 CH3 OCF2CF2H H H OC2H5 CH3 SCF2CF2H H H OC2H5 CH3 CH2OCH2CH(CH3)2 H H OC2H5 CH3 CH2O(CH2)3CH3 H H OC2H5 CH3 CH2OC2H5 H H OC2H5 CH3 SCH3 H H OC2H5 CH3 CO2CH2CH2Cl H H OC2H5 CH3 CO2CH2CH=CH2 H H OC2H5 CH3 CO2CH(CH3)2 H H OC2H5 CH3 OSO2CHFCF2H H CH3 OC2H5 CH3 OSO2HCFCFCl3 H CH3 OC2H5 CH3 OSO2CHFC2F H CH3 OC2H5 CH3 OSO2CH2CH2Cl H CH3 OC2H5 CH3 SO2N(CH3)2 H Table 13 (continued) R' R1' R2' R7' R8 m.p.( C) CH3 OC2H5 CH3 SO2N(CH3)[(CH2)2CH3] H CH3 OC2H5 CH3 SO2N(OCH3)CH3 H CH3 OC2H5 CH3 CO2CH2CH(CH3)2 H CH3 OC2H5 CH3 OCH2CH(CH3)2 H CH3 OC2H5 CH3 SO2CH3 H CH3 OC2H5 CH3 CO2CH3 H CH3 OC2H5 CH3 OSO2CH(CH3)2 H CH3 OC2H5 CH3 CF3 H CH3 OC2H5 CH3 OCF2CF2H H CH3 OC2H5 C2H5 Cl H CH3 OC2H5 C2H5 SCHF2 H CH3 OC2H5 C2H5 SO2(CH2)2CH3 H CH3 OC2H5 C2H5 CO2C2H5 H CH3 OC2H5 CH3 OSO2(CH2)3Cl H H CH3 CH3 CO2CH2CH2CH2CH2CH3 H H CH3 CH3 CO2CH2CH2CH2CH2CH2CH3 H H CH3 CH3 CO2CH2CH2OCH2CH3 H H CH3 CH3 CO2CH2CH2CH2OCH2CH3 H H CH3 CH3 CO2CH2CH=CH2 H H CH3 CH3 CO2CH2CH=CH-CH3 H H CH3 CH3 CO2CH2CH=CH-CH2CH3 H H CH3 CH3 CO2CH2CH=CH-CH2CH2CH3 H H CH3 CH3 CO2CH2C#CH H H CH3 CH3 CO2CH2C#C-CH3 H H CH3 CH3 CO2CH2C#C-CH2CH3 H H CH3 CH3 CO2CH2C#C-CH2CH2CH3 H H CH3 CH3 CO2CH2CF3 H H CH3 CH3 CO2CH2CCl3 H H CH3 CH3 CO2CH2CH2Cl H H CH3 CH3 CO2CH2CH2F H H CH3 CH3 CH2CO2CH3 H Table 13 (continued) R' R1' R2' R7 R8 m.p.( C) H CH3 CH3 CH2CO2CH2CH2CH2CH3 H H CH3 CH3 CH2CO2CH2CH2OCH3 H H CH3 CH3 CH2CO2CH2CH2Cl H H CH3 CH3 CH2CO2CH2CH=CH2 H H CH3 CH3 CH(CH3)CO2CH3 H H CH3 CH3 CH(CH3)CO2CH2CH2CH2CH3 H H CH3 CH3 CH(CH3)CO2CH2CH2OCH3 H H CH3 CH3 CH(CH3)CO2CH2CH2Cl H H CH3 CH3 CH(CH3)CO2CH2CH=CH2 H H CH3 CH3 SCH2CH=CH2 H H CH3 CH3 SOCH2CH=CH2 H H CH3 CH3 SO2CH2CH=CH2 H H CH3 CH3 SCH2CH=CH-CH3 H H CH3 CH3 SOCH2CH=CH-CH3 H H CH3 CH3 SO2CH2CH=CH-CH3 H H CH3 CH3 CH2SCH2CH=CH2 H H CH3 CH3 CH2SOCH2CH=CH2 H H CH3 CH3 CH2SO2CH2CH=CH2 H H CH3 CH3 CH2SCH2CH=CH-CH3 H H CH3 CH3 CH2SOCH2CH=CH-CH3 H H CH3 CH3 CH2SO2CH2CH=CH-CH3 H H CH3 CH3 CH(CH3)SCH2CH=CH2 H H CH3 CH3 CH(CH3)SOCH2CH=CH2 H H CH3 CH3 CH(CH3)SO2CH2CH=CH3 H H CH3 CH3 CH(CH3)SCH2CH=CH-CH3 H H CH3 CH3 CH(CH3)SOCH2CH=CH-CH3 H H CH3 CH3 CH(CH3)SO2CH2CH=CH-CH3 H H CH3 CH3 CH(CH3)SO2CH3 H H CH3 CH3 CH(CH3)SO2CH2CH2CH3 H H CH3 CH3 CH(CH3)SO2CH2CH2OCH3 H H CH3 CH3 CH(CH3)SO2CH2CH2CH2OCH3 H Table 13 (continued) R' R1' R2' R7 R8 m.p.( C) H CH3 CH3 N(CH3)SO2CH2CH2C H H CH3 CH3 N(CH3)SO2CH2CH2F H H CH3 CH3 CH2OCH3 H H CH3 CH3 CH2CH2OCH3 H H CH3 CH3 CH2OCH2CH3 H H CH3 CH3 CH2CH2OCH2CH3 H H CH3 CH3 OCH2CH=CH2 H H CH3 CH3 OCH2CH=CH-CH3 H H CH3 CH3 OCH2CH#CH H H CH3 CH3 OCH2C#C-CH3 H H CH3 CH3 OCH2Cl H H CH3 CH3 OCH2F H H CH3 CH3 OCH2OCH3 H H CH3 CH3 OCH2OCH2CH3 H H CH3 CH3 OCH2CH2Cl H H CH3 CH3 OCH2CH2F H H CH3 CH3 OCH2CH2OCH3 H H CH3 CH3 OCH2CH2OCH2CH3 H H OCH3 CH3 CO2CH2CH2CH2CH2CH3 H H OCH3 CH3 CO2CH2CH2CH2CH2CH2CH3 H H OCH3 CH3 CO2CH2CH2OCH2CH3 H H OCH3 CH3 CO2CH2CH2CH2OCH2CH3 H H OCH3 CH3 CO2CH2CH2CH2OCH2CH3 H H OCH3 CH3 CO2CH2CH2CH=CH2 H H OCH3 CH3 CO2CH2CH2CH=CH-CH3 H H OCH3 CH3 CO2CH2CH2CH=CH-CH2CH3 H H OCH3 CH3 CO2CH2CH2CH=CH-CH2CH2CH3 H H OCH3 CH3 CO2CH2CH2C#CH H H OCH3 CH3 CO2CH2CH2C#C-CH3 H H OCH3 CH3 CO2CH2CH2C#C-CH2CH2CH3 H H OCH3 CH3 CO2CH2CH2CF3 H Table 13 (continued) R' R1' R2' R7 R8 m.p.( C) H OCH3 CH3 CO2CH2CCl3 H H OCH3 CH3 CO2CH2CH2Cl H H OCH3 CH3 C02CH2CH2F H H OCH3 CH3 CH2CO2CH3 H H OCH3 CH3 CH2CO2CH2CH2CH2CH3 H H OCH3 CH3 CH2CO2CH2CH2OCH3 H H OCH3 CH3 CH2CO2CH2CH2Cl H H OCH3 CH3 CH2CO2CH2CH=CH2 H H OCH3 CH3 CH(CH3)C02CH3 H H OCH3 CH3 CH(CH3)CO2CH2CH2CH2CH3 H H OCH3 CH3 CH(CH3)CO2CH2CH2OCH3 H H OCH3 CH3 CH(CH3)CO2CH2CH2Cl H H OCH3 CH3 CH(CH3)CO2CH2CH=CH2 H H OCH3 CH3 SCH2CH=CH2 H H OCH3 CH3 SOCH2CH=CH2 H H OCH3 CH3 SO2CH2CH=CH2 H H OCH3 CH3 SCH2CH=CH-CH3 H H OCH3 CH3 SOCH2CH=CH-CH3 H H OCH3 CH3 SO2CH2CH=CH-CH3 H H OCH3 CH3 CH2SCH2CH=CH2 H H OCH3 CH3 CH2SOCH2CH=CH2 H H OCH3 CH3 CH2SO2CH2CH=CH2 H H OCH3 CH3 CH2SCH2CH=CH-CH3 H H OCH3 CH3 CH2SOCH2CH=CH-CH3 H H OCH3 CH3 CH2SO2CH2CH=CH-CH3 H H OCH3 CH3 CH(CH3)SCH2CH=CH2 H H OCH3 CH3 CH(CH3)SOCH2CH=CH2 H H OCH3 CH3 CH(CH3)SO2CH2CH=CH3 H H OCH3 CH3 CH(CH3)SCH2CH=CH-CH3 H H OCH3 CH3 CH(CH3)SOCH2CH=CH-CH3 H H OCH3 CH3 CH(CH3)SO2CH2CH=CH-CH3 H Table 13 (continued) R' R1' R2' R7 R8 m.p.( C) H OCH3 CH3 N(CH3)SO2CH3 H H OCH3 CH3 N(CH3)SO2CH2CH2CH2CH3 H H OCH3 CH3 N(CH3)SO2CH2CH2OCH3 H H OCH3 CH3 N(CH3)SO2CH2CH2CH2OCH3 H H OCH3 CH3 N(CH3)SO2CH2CH2Cl H H OCH3 CH3 N(CH3)SO2CH2CH2F H H OCH3 CH3 CH2OCH3 H H OCH3 CH3 CH2CH2OCH3 H H OCH3 CH3 CH2OCH2CH3 H H OCH3 CH3 CH2CH2OCH2CH3 H H OCH3 CH3 OCH2CH=CH2 H H OCH3 CH3 OCH2CH=CH-CH3 H H OCH3 CH3 OCH2C#CH H H OCH3 CH3 OCH2C#C-CH3 H H OCH3 CH3 OCH2Cl H H OCH3 CH3 OCH2F H H OCH3 CH3 OCH2OCH3 H H OCH3 CH3 OCH2OCH2CH3 H H OCH3 CH3 OCH2CH2Cl H H OCH3 CH3 OCH2CH2F H H OCH3 CH3 OCH2CH2OCH3 H H OCH3 CH3 OCH2CH2OCH2CH3 H H SCH3 CH3 CO2CH2CH2CH2CH2CH3 H H SCH3 CH3 CO2CH2CH2CH2CH2CH2CH3 H H SCH3 CH3 CO2CH2CH2OCH2CH3 H H SCH3 CH3 CO2CH2CH2CH2OCH2CH3 H H SCH3 CH3 CO2CH2CH=CH2 H H SCH3 CH3 CO2CH2CH=CH-CH3 H H SCH3 CH3 CO2CH2CH=CH-CH2CH3 H H SCH3 CH3 CO2CH2CH=CH-CH2CH2CH3 H H SCH3 CH3 CO2CH2C#CH H Table 13 (continued) R1' R2' R7 R8 m.p.( C) H SCH3 CH3 CO2CH2C#C-CH3 H H SCH3 CH3 CO2CH2C#C-CH2CH3 H H SCH3 CH3 CO2CH2C#C-CH2CH2CH3 H H SCH3 CH3 CO2CH2CF3 H H SCH3 CH3 CO2CH2CCl H H SCH3 CH3 C02CH2CH2C1 H H SCH3 CH3 C02CH2CH2F H H SCH3 CH3 CH2CO2CH3 H H SCH3 CH3 CH2CO2CH2CH2CH2CH3 H H SCH3 CH3 CH2CO2CH2CH2OCH3 H H SCH3 CH3 CH2CO2CH2CH2Cl H H SCH3 CH3 CH2CO2CH2CH=CH2 H H SCH3 CH3 CH2(CH3)CO2CH2 H H SCH3 CH3 CH2(CH3)CO2CH2CH2CH2CH3 H H SCH3 CH3 CH2(CH3)CO2CH2CH2OCH3 H H SCH3 CH3 CH2(CH3)CO2CH2CH2Cl H H SCH3 CH3 CH(CH3)C02CH2CH=CH2 H H SCH3 CH3 SCH2CH=CH2 H H SCH3 CH3 SOCH2CH=CH2 H H SCH3 CH3 SO2CH2CH=CH2 H H SCH3 CH3 SCH2CH=CH-CH3 H H SCH3 CH3 SOCH2CH=CH-CH3 H H SCH3 CH3 SO2CH2CH=CH-CH3 H H SCH3 CH3 CH2SCH2CH=CH2 H H SCH3 CH3 CH2SOCH2CH=CH2 H H SCH3 CH3 CH2SO2CH2CH=CH2 H H SCH3 CH3 CH2SCH2CH=CH-CH3 H H SCH3 CH3 CH2SOCH2CH=CH-CH3 H H SCH3 CH3 CH2SO2CH2CH=CH-CH3 H H SCH3 CH3 CH(CH3)SCH2CH=CH2 H H SCH3 CH3 CH(CH3)SOCH2CH=CH2 H Table 13 (continued) R' R1' R2' R7 R8 m.p. ( C) H SCH3 CH3 CH(CH3)SO2CH2CH=CH3 H H SCH3 CH3 CH(CH3)SOCH2CH=CH-CH3 H H SCH3 CH3 CH(CH3)SOCH2CH=CH-CH3 H H SCH3 CH3 N(CH3)SO2CH3 H H SCH3 CH3 N(CH3)SO2CH2CH2CH2CH3 H H SCH3 CH3 N(CH3)SO2CH2CH2OCH3 H H SCH3 CH3 N(CH3)SO2CH2CH2CH2OCH3 H H SCH3 CH3 N(CH3)SO2CH2CH2Cl H H SCH3 CH3 N(CH3)SO2CH2CH2F H H SCH3 CH3 CH2OCH3 H H SCH3 CH3 CH2CH2OCH3 H H SCH3 CH3 CH2OCH2CH3 H H SCH3 CH3 CH2CH2OCH2CH3 H H SCH3 CH3 OCH2CH=CH2 H H SCH3 CH3 OCH2CH2=CH-CH3 H H SCH3 CH3 OCH2C#CH H H SCH3 CH3 OCH2C#C-CH3 H H SCH3 CH3 OCH2Cl H H SCH3 CH3 OCH2F H H SCH3 CH3 OCH2OCH3 H H SCH3 CH3 OCH2OCH2CH3 H H SCH3 CH3 OCH2CH2Cl H H SCH3 CH3 OCH2CH2F H H SCH3 CH3 OCH2CH2F H H SCH3 CH3 OCH2CH2OCH3 H H SCH3 CH3 OCH2CH2OCH2CH3 H CH3 CH3 CH3 CO2CH2CH2CH2CH2CH3 H CH3 CH3 CH3 CO2CH2CH2CH2CH2CH2CH3 H CH3 CH3 CH3 CO2CH2CH2OCH2CH3 H CH3 CH3 CH3 CO2CH2CH2CH2OCH2CH3 H CH3 CH3 CH3 CO2CH2CH=CH2 H Table 13 (continued) R' R1' R2' R7' R8 m.p.( C) CH3 CH3 CH3 CO2CH2CH=CH-CH3 H CH3 CH3 CH3 CO2CH2CH=CH-CH2CH3 H CH3 CH3 CH3 CO2CH2CH=CH-CH2CH2CH3 H CH3 CH3 CH3 CO2CH2C#CH H CH3 CH3 CH3 CO2CH2C#C-CH3 H CH3 CH3 CH3 CO2CH2C#C-CH2CH3 H CH3 CH3 CH3 CO2CH2C#C-CH2CH2CH3 H CH3 CH3 CH3 CO2CH2CF3 H CH3 CH3 CH3 CO2CH2CCl3 H CH3 CH3 CH3 CO2CH2CH2Cl H CH3 CH3 CH3 CO2CH2CH2F H CH3 CH3 CH3 CH2CO2CH3 H CH3 CH3 CH3 CH2CO2CH2CH2CH2CH3 H CH3 CH3 CH3 CH2CO2CH2CH2OCH3 H CH3 CH3 CH3 CH2CO2CH2CH2Cl H CH3 CH3 CH3 CH2CO2CH2CH=CH2 H CH3 CH3 CH3 CH(CH3)CO2CH3 H CH3 CH3 CH3 CH(CH3)CO2CH2CH2CH2CH3 H CH3 CH3 CH3 CH(CH3)CO2CH2CH2OCH3 H CH3 CH3 CH3 CH(CH3)CO2CH2CH2Cl H CH3 CH3 CH3 CH(CH3)CO2CH2CH=CH2 H CH3 CH3 CH3 SCH2CH=CH2 H CH3 CH3 CH3 SOCH2CH=CH2 H CH3 CH3 CH3 SO2CH2CH=CH2 H CH3 CH3 CH3 SCH2CH=CH-CH3 H CH3 CH3 CH3 SOCH2CH=CH-CH3 H CH3 CH3 CH3 SO2CH2CH=CH-CH3 H CH3 CH3 CH3 CH2SCH2CH=CH2 H CH3 CH3 CH3 CH2SOCH2CH=CH2 H CH3 CH3 CH3 CH2SO2CH2CH=CH2 H CH3 CH3 CH3 CH2SCH2CH=CH-CH3 H Table 13 (continued) R' R1' R2' R7 R8 m.p. ( C) CH3 CH3 CH3 CH2SOCH2CH=CH-CH3 H CH3 CH3 CH3 CH2SO2CH2CH=CH-CH3 H CH3 CH3 CH3 CH(CH3)SCH2CH=CH2 H CH3 CH3 CH3 CH(CH3)SOCH2CH=CH2 H CH3 CH3 CH3 CH(CH3)SO2CH2CH=CH3 H CH3 CH3 CH3 CH(CH3)SCH2CH=CH-CH3 H CH3 CH3 CH3 CH(CH3)SOCH2CH=CH-CH3 H CH3 CH3 CH3 CH(CH3)SO2CH2CH=CH-CH3 H CH3 CH3 CH3 N(CH3)502CH3 H CH3 CH3 CH3 N(CH3)SO2CH2CH2CH2CH3 H CH3 CH3 CH3 N(CH3)SO2CH2CH2OCH3 H CH3 CH3 CH3 N(CH3)SO2CH2CH2CH2OCH3 H CH3 CH3 CH3 N(CH3)SO2CH2CH2Cl H CH3 CH3 CH3 N(CH3)SO2CH2CH2F H CH3 CH3 CH3 CH2 CH3 H CH3 CH3 CH3 CH2CH2OCH3 H CH3 CH3 CH3 CH2OCH2CH3 H CH3 CH3 CH3 CH2CH2 CH2CH3 H CH3 CH3 CH3 OCH2CH=CH2 H CH3 CH3 CH3 OCH2CH=CH-CH3 H CH3 CH3 CH3 OCH2C#CH H CH3 CH3 CH3 OCH2C#C-CH3 H CH3 CH3 CH3 OCH2Cl H CH3 Ch3 CH3 OCH2F H CH3 CH3 CH3 OCH2OCH3 H CH3 CH3 CH3 OCH2OCH2CH3 H CH3 CH3 CH3 OCH2CH2Cl H CH3 CH3 CH3 OCH2CH2F H CH3 CH3 CH3 OCH2CH2OCH3 H CH3 CH3 CH3 OCH2CH2OCH2CH3 H CH3 OCH3 CH3 CO2CH2CH2CH2CH2CH3 H Table 13 (continued) R' R1' R2' R7 R8 m.p.( C) CH3 OCH3 CH3 CO2CH2CH2CH2CH2CH2CH3 H CH3 OCH3 CH3 CO2CH2CH2OCH2CH3 H CH3 OCH3 CH3 CO2CH2CH2CH2OCH2CH3 H CH3 OCH3 CH3 CO2CH2CH=CH2 H CH3 OCH3 CH3 CO2CH2CH=CH-CH3 H CH3 OCH3 CH3 CO2CH2CH=CH-CH2CH3 H CH3 OCH3 CH3 CO2CH2CH=CH-CH2CH2CH3 H CH3 OCH3 CH3 CO2CH2C#CH H CH3 OCH3 CH3 CO2CH2C#C-CH3 H CH3 OCH3 CH3 CO2CH2C#C-CH2CH3 H CH3 OCH3 CH3 CO2CH2C#C-CH2CH2CH3 H CH3 OCH3 CH3 CO2CH2CF3 H CH3 OCH3 CH3 CO2CH2CCl3 H CH3 OCH3 CH3 CO2Ch2CH2Cl H CH3 OCH3 CH3 CO2CH2CH2F H CH3 OCH3 CH3 CH2CO2CH3 H CH3 OCH3 CH3 CH2CO2CH2CH2CH2CH3 H CH3 OCH3 CH3 CH2CO2CH2CH2OCH3 H CH3 OCH3 CH3 CH2CO2CH2CH2Cl H CH3 OCH3 CH3 CH2CO2CH2CH=CH2 H CH3 OCH3 CH3 CH(CH3)CO2CH3 H CH3 OCH3 CH3 CH(CH3)CO2CH2CH2CH2CH3 H CH3 OCH3 CH3 CH(CH3)CO2CH2CH2OCH3 H CH3 OCH3 CH3 CH(CH3)CO2CH2CH2Cl H CH3 OCH3 CH3 CH(CH3)CO2CH2CH=CH2 H CH3 OCH3 CH3 SCH2CH=CH2 H CH3 OCH3 CH3 SOCH2CH=CH2 H CH3 OCH3 CH3 SO2CH2CH=CH2 H CH3 OCH3 CH3 SCH2CH=CH-CH3 H CH3 OCH3 CH3 SOCH2CH=CH-CH3 H CH3 OCH3 CH3 SO2CH2CH=CH-CH3 H Table 13 (continued) R' R1' R2' R7 R8 m.p.( C) CH3 OCH3 CH3 CH2SCH2CH=CH2 H CH3 OCH3 CH3 CH2SOCH2CH=CH2 H CH3 OCH3 CH3 CH2SO2CH2CH=CH2 H CH3 OCH3 CH3 CH2SCH2CH=CH-CH3 H CH3 OCH3 CH3 CH2SOCH2CH=CH-CH3 H CH3 OCH3 CH3 CH2SO2CH2CH=CH-CH3 H CH3 OCH3 CH3 CH(CH3)SCH2CH=CH2 H CH3 OCH3 CH3 CH(CH3)SOCH2CH=CH2 H CH3 OCH3 CH3 CH(CH3)SO2CH2CH=CH3 H CH3 OCH3 CH3 CH(CH3)SCH2CH=CH-CH3 H CH3 OCH3 CH3 CH(CH3)SOCH2CH=CH-CH3 H CH3 OCH3 CH3 CH(CH3)SO2CH2CH=CH-CH3 H CH3 OCH3 CH3 N(CH3)SO2CH3 H CH3 OCH3 CH3 N(CH3)SO2CH2CH2CH2CH3 H CH3 OCH3 CH3 N(CH3)SO2CH2CH2OCH3 H CH3 OCH3 CH3 N(CH3)SO2CH2CH2CH2OCH3 H CH3 OCH3 CH3 N(CH3)SO2CH2CH2Cl H CH3 OCH3 CH3 N(CH3)SO2CH2CH2F H CH3 OCH3 CH3 CH2OCH3 H CH3 OCH3 CH3 CH2CH2OCH3 H CH3 OCH3 CH3 CH2OCH2CH3 H CH3 OCH3 CH3 CH2CH2OCH2CH3 H CH3 OCH3 CH3 OCH2CH=CH2 H CH3 OCH3 CH3 OCH2CH=CH-CH3 H CH3 OCH3 CH3 OCH2C#CH H CH3 OCH3 CH3 OCH2C#C-CH3 H CH3 OCH3 CH3 OCH2Cl H CH3 OCH3 CH3 OCH2F H CH3 OCH3 CH3 OCH2OCH3 H CH3 OCH2 CH3 OCH2OCH2CH3 H CH3 OCH2 CH3 OCH2CH2Cl H Table 13 (continued) R' R1' R2' R7 CH3 OCH3 CH3 OCH2CH2F H CH3 OCH3 CH3 OCH2CH2OCH3 H CH3 OCH3 CH3 OCH2CH2OCH2CH3 H CH3 SCH3 CH3 CO2CH2CH2CH2CH2CH3 H CH3 SCH3 CH3 CO2CH2CH2CH2CH2CH2CH3 H CH3 SCH3 CH3 CO2CH2CH2OCH2CH3 H CH3 SCH3 CH3 CO2CH2CH2CH2OCH2CH3 H CH3 SCH3 CH3 CO2CH2CH=CH2 H CH3 SCH3 CH3 CO2CH2CH=CH-CH3 H CH3 SCH3 CH3 CO2CH2CH=CH-CH2CH3 H CH3 SCH3 CH3 CO2CH2CH=CH-CH2CH2CH3 H CH3 SCH3 CH3 CO2CH2C#CH H CH3 SCH3 CH3 CO2CH2C#C-CH3 H CH3 SCH3 CH3 CO2CH2C#C-CH2CH3 H CH3 SCH3 CH3 CO2CH2C#C-CH2CH2CH3 H CH3 SCH3 CH3 CO2CH2CF3 H CH3 SCH3 CH3 CO2CH2CCl3 H CH3 SCH3 CH3 CO2CH2CH2Cl H CH3 SCH3 CH3 CO2CH2CH2F H CH3 SCH3 CH3 CH2CO2CH3 H CH3 SCH3 CH3 CH2CO2CH2CH2CH2CH3 H CH3 SCH3 CH3 CH2CO2CH2CH2OCH3 H CH3 SCH3 CH3 CH2CO2CH2CH2Cl H CH3 SCH3 CH3 CH2CO2CH2CH=CH2 H CH3 SCH3 CH3 CH(CH3)CO2CH3 H CH3 SCH3 CH3 CH(CH3)COCH2CH2CH2CH3 H CH3 SCH3 CH3 CH(CH3)CO2CH2CH2OCH3 H CH3 SCH3 CH3 CH(CH3)CO2CH2CH2Cl H CH3 SCH3 CH3 CH(CH3)CO2CH2CH=CH2 H CH3 SCH3 CH3 SCH2CH=CH2 H CH3 SCH3 CH3 SOCH2CH=CH2 H Table 13 (continued) R' R1' R2' R7 R8 m.p.( C) CH3 SCH3 CH3 SO2CH2CH=CH2 H CH3 SCH3 CH3 SCH2CH=CH-CH3 H CH3 SCH3 CH3 SOCH2CH=CH-CH3 H CH3 SCH3 CH3 SO2CH2CH=CH-CH3 H CH3 SCH3 CH3 CH2SCH2CH=CH2 H CH3 SCH3 CH3 CH2SOCH2CH=CH2 H CH3 SCH3 CH3 CH2SO2CH2CH=CH2 H CH3 SCH3 CH3 CH2SCH2CH=CH-CH3 H CH3 SCH3 CH3 CH2SOCH2CH=CH-CH3 H CH3 SCH3 CH3 CH2SO2CH2CH=CH-CH3 H CH3 SCH3 CH3 CH(CH3)SCH2CH=CH2 H CH3 SCH3 CH3 CH(CH3)SOCH2CH=CH2 H CH3 SCH3 CH3 CH(CH3)SO2CH2CH=CH3 H CH3 SCH3 CH3 CH(CH3)SCH2CH=CH-CH3 H CH3 SCH3 CH3 CH(CH3)SOCH2CH=CH-CH3 H CH3 SCH3 CH3 CH(CH3)SO2CH2CH=CH-CH3 H CH3 SCH3 CH3 N(CH3)SO2CH3 H CH3 SCH3 CH3 N(CH3)SO2CH2CH2CH2CH3 H CH3 SCH3 CH3 N(CH3)SO2CH2CH2OCH3 H CH3 SCH3 CH3 N(CH3)SO2CH2CH2CH2OCH3 H CH3 SCH3 CH3 N(CH3)SO2CH2CH2Cl H CH3 SCH3 CH3 N(CH3)SO2CH2CH2F H CH3 SCH3 CH3 CH2OCH3 H CH3 SCH3 CH3 CH2CH2OCH3 H CH3 SCH3 CH3 CH2OCH2CH3 H CH3 SCH3 CH3 CH2CH2OCH2CH3 H CH3 SCH3 CH3 OCH2CH=CH2 H CH3 SCH3 CH3 OCH2CH=CH-CH3 H CH3 SCH3 CH3 OCH2C#CH H CH3 SCH3 CH3 OCH2C#C-CH3 H CH3 SCH3 CH3 OCH2Cl H Table 13 (continued) R' R'1 R'2 R7 R8 m.p.(O C) CH3 SCH3 CH3 OCH2F H CH3 SCH3 CH3 OCH2OCH3 H CH3 SCH3 CH3 OCH2OCH2CH3 H CH3 SCH3 CH3 OCH2CH2Cl H CH3 SCH3 CH3 OCH2OCH2F H CH3 SCH3 CH3 OCH2CH2OCH3 H CH3 SCH3 CH3 OCH2CH2OCH2CH3 H Table 14 EMI176.1 R' R1' R2' R16 m.p.( C) CH3 H C2H5 CO2CH3 CH3 CH3 C2H5 Cl CH3 CH3 C2H5 H CH3 CH3 C2H5 Cl CH3 CH3 C2H5 CO2CH(CH3)C2H5 CH3 CH3 C2H5 CO2CH3 CH3 C2H5 CH3 CO2(CH2)3CH3 CH3 C2H5 CH3 Cl CH3 C2H5 CH3 Cl CH3 C2H5 CH3 CO2CH2CH2OCH3 CH3 C2H5 C2H5 CO2CH2CH(CH3)2 CH3 C2H5 CH3 SO2N(CH3)2 CH3 C2H5 CH3 SO2N(CH3)OCH3 H CH3 C2H5 SCH3 H C2H5 CH3 S(CH3)OCH3 H C2H5 CH3 F H C2H5 CH3 CH3 H C2H5 CH3 SO2CH3 H C2H5 C2H5 n-C4H9 H SCH3 CH3 CH3 H SCH3 CH3 H H SCH3 CH3 Cl H SCH3 CH3 NO2 H SCH3 CH3 Cl H SCH3 CH3 Cl H SCH3 CH3 Cl Table 14 (continued) R' R1' R2' R16 m.p.( C) H SCH3 CH3 SO2CH3 H SCH3 C2H5 SO2CH3 H SCH3 CH3 SO2N(CH3)2 H CH3 C2H5 NO2 H C2H5 CH3 CH3 H SCH3 CH3 Cl H SCH3 C2H5 OCH3 H SCH3 CH3 CO2CH2CH=CH2 H SCH3 CH3 CO2CH(CH3)2 H SCH3 C2H5 CO2CH2CH2Cl H SCH3 CH3 CO2CH2CH2(CH3)2 H SCH3 C2H5 n-C4H9 H SCH3 CH3 SCH3 H SCH3 CH3 S(CH2)2CH3 H SCH3 CH3 F H SC2H5 CH3 CH3 H SC2H5 CH3 SO2CH3 H OCH3 C2H5 Cl H OCH3 C2H5 Cl H OCH3 C2H5 H H OCH3 C2H5 F H OCH3 C2H5 H H OCH3 C2H5 H H OCH3 C2H5 Cl H OCH3 C2H5 SO2Ch3 H OCH3 C2H5 CF3 H OCH3 C2H5 NO2 H OC2H5 CH3 CH3 H OC2H5 CH3 OC2H5 H OC2H5 CH3 Cl H OC2H5 CH3 SO2CH3 H OC2H5 CH3 SO2CH3 Table 14 (continued) R' R1' R2' R16 m.p.( C) H OC2H5 CH3 SO2N(CH3)[(CH2)2CH3] H OCH3 C2H5 SO2N(CH3)2 H OCH3 C2H5 SO2N(CH3)OCH3 H OCH3 C2H5 SO2C2H5 H OC2H5 CH3 SO2(CH2)3CH3 CH3 OC2H5 CH3 Cl CH3 OCH3 C2H5 NO2 CH3 OCH3 C2H5 Cl CH3 OCH3 C2H5 Br CH3 OCH3 C2H5 OCH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OC2H5 CH3 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SCH3 CH3 OC2H5 CH3 S(CH2)3CH3 CH3 OC2H5 CH3 SO2N(CH3)C2H5 CH3 OC2H5 CH3 CF3 CH3 OCH3 C2H5 Br CH3 OCH3 C2H5 NO2 CH3 OCH3 C2H5 n-C3H7 CH3 OC2H5 CH3 OCH2(CH2)2Ch3 CH3 OC2H5 CH3 OCH2CH(CH3)2 CH3 OC2H5 CH3 OC2H5 CH3 OCH3 CH3 CO2CH2CH2OCH3 CH3 OCH3 C2H5 CO2(CH2)3OCH3 CH3 OCH3 C2H5 CO2(CH2)2OCH3 CH3 OC2H5 C2H5 CO2CH2CH2Cl CH3 OCH3 C2H5 CO2C2H5 CH3 OCH3 C2H5 CO2CH3 CH3 OC2H5 C2H5 SO2N(C2H5)2 CH3 SCH3 CH3 SO2N(CH3)2 Table 14 (continued) R' R1' R2' R16 m.p.( C) CH3 SCH3 CH3 SO2(CH2)3CH3 CH3 SCH3 CH3 S(CH2)3CH3 CH3 SCH3 CH3 SO2CH2CH(CH3)2 CH3 SCH3 CH3 SCH(CH3)2 CH3 OC2H5 CH3 NO2 CH3 SCH3 CH3 NO2 CH3 SCH3 CH3 CO2CH2CH2OCH3 CH3 SCH3 CH3 O-CH(CH3)C2H5 CH3 SCH3 CH3 SO2(CH2)CH3 CH3 OC2H5 C2H5 F CH3 SCH3 CH3 SO2N(OCH3)CH3 Table 15 EMI180.1 RÚ R1' R2' R18 m.p.( C) CH3 H C2H5 CO2CH3 CH3 CH3 C2H5 Br CH3 CH3 C2H5 CO2CH(CH3)2 CH3 CH3 C2H5 NO2 CH3 CH3 C2H5 H CH3 CH3 C2H5 Cl CH3 CH3 C2H5 Cl CH3 CH3 C2H5 CO2CH2CH=CH2 CH3 CH3 C2H5 CO2CH2CH2Cl CH3 CH3 C2H5 CO2CH3 CH3 CH3 C2H5 SO2CH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 OCH3 CH3 CH3 C2H5 SO2N(CH3)2 CH3 CH3 C2H5 NO2 CH3 CH3 C2H5 SO2N(CH3)OCH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 Br CH3 CH3 C2H5 Br CH3 CH3 C2H5 Cl CH3 C2H5 C2H5 Br CH3 C2H5 C2H5 CO2CH3 H C2H5 C2H5 SO2CH3 H C2H5 C2H5 SO2N(CH3)C2H5 H CH3 C2H5 SO2(CH2)2CH3 Table 15 (continued) RÚ R1' R2' R18 m.p.( C) H C2H5 CH3 SCH3 H C2H5 C2H5 SO2CH3 H C2H5 C2H5 CO2CH3 H C2H5 C2H5 H H CH3 C2H5 H H CH3 C2H5 H H C2H5 C2H5 SO2N(CH3)2 H C2H5 C2H5 Br H CH3 C2H5 F H C2H5 C2H5 F H SCH3 CH3 Br H SCH3 CH3 Br H SCH3 CH3 Br H SCH3 CH3 H H SCH3 CH3 Cl H SCH3 CH3 NO2 H SCH3 CH3 SO2N(CH3)C2H5 H SCH3 CH3 SO2N(CH3)[CH(CH3)2] CH3 SCH3 CH3 F CH3 SCH3 CH3 H CH3 SCH3 CH3 H CH3 SCH3 CH3 H CH3 SCH3 CH3 502CH3 CH3 SCH3 CH3 CO2CH3 CH3 SCH3 CH3 SO2N(CH3)2 CH3 SCH3 CH3 OC2H5 CH3 SCH3 CH3 H CH3 SCH3 CH3 CO2(CH2)3CH3 CH3 SCH3 CH3 CO2CH2CH2OCH3 CH3 SCH3 CH3 H CH3 SCH3 CH3 OCH(CH3)C2H5 Table 15 (continued) R1' R2' R18 m.p.( C) CH3 SCH3 CH3 CH3 CH3 SCH3 CH3 SCH3 CH3 SCH3 CH3 S(CH2)3CH3 CH3 SCH3 C2H5 SO2C2H5 CH3 SCH3 CH3 C02CH(CH3)2 CH3 SCH3 CH3 CO2CH2CH=CH2 CH3 SCH3 C2H5 CO2CH3 CH3 SCH3 C2H5 Br CH3 SCH3 C2H5 SO2CH3 CH3 SCH3 C2H5 Cl CH3 SCH3 C2H5 NO2 H SCH3 CH3 CO2CH3 H SCH3 CH3 SO2N(CH3)C2H5 H OCH3 CH3 Br H OCh3 CH3 Cl H OCH3 CH3 N02 H OCH3 CH3 SO2CH3 H OCH3 CH3 SO2CH3 H OCH3 CH3 SO2CH3 H OCH3 CH3 S02(CH2)2CH3 H OCH3 CH3 OCH3 H OC2H5 CH3 O(CH2)3CH3 H OC2H5 CH3 CO2CH2CH=CH2 H OCH3 CH3 CO 2 2 H OCH3 C2H5 CO2CH(CH3)2 H OCH3 C2H5 CO2(CH2)2CH3 H OC2H5 CH3 C02C2H5 H OCH3 C2H5 CO2CH3 H OCH3 C2H5 Cl H OC2H5 CH3 Br H OCH3 C2H5 SO2CH3 H OCH3 C2H5 SO2(CH2)3CH3 Table 15 (continued) R' R1' R2' R18 m.p.( C) CH3 OCH3 C2H5 SO2CH2CH(CH3)2 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 OC2H5 CH3 OCH3 C2H5 F CH3 OCH3 C2H5 F CH3 OC2H5 C2H5 SC2H5 CH3 OC2H5 CH3 SO2N(OCH3)CH3 CH3 OC2H5 CH3 SO2N(CH3)[(CH2)2CH3] CH3 OC2H5 CH3 H CH3 OC2H5 CH3 NO2 CH3 OC2H5 CH3 CO2CH(CH3)2 CH3 OC2H5 CH3 CO2CH2CH=CH2 CH3 OC2H5 CH3 CO2CH2CH2Cl CH3 OC2H5 CH3 CH3 CH3 OC2H5 CH3 CH(CH3)2 CH3 OC2H5 CH3 CH2CH(CH3)2 CH3 OC2H5 CH3 CH3 CH3 OC2H5 CH3 SO2CH3 CH3 OC2H5 CH3 Cl CH3 OC2H5 CH3 C2H5 CH3 OC2H5 CH3 NO2 CH3 OC2H5 CH3 Br CH3 OC2H5 CH3 Cl CH3 OC2H5 C2H5 Cl CH3 OC2H5 C2H5 CO2CH3 CH3 OC2H5 C2H5 SO2CH3 CH3 OC2H5 C2H5 SO2N(CH3)2 H OC2H5 C2H5 NO2 H OC2H5 C2H5 Br Table 15 (continued) R' R1' R2' R18 m.p.( C) H OC2H5 C2H5 CO2CH(CH3)2 H OCH3 C2H5 SO2C2H5 H OCH3 C2H5 F H OC2H5 CH3 OCH(CH3)2 CH3 OC2H5 CH3 SO2(CH2)2CH3 CH3 OC2H5 CH3 SO2CH(CH3)2 CH3 OC2H5 CH3 SO2N(C2H5)2 Table 16 EMI185.1 R' R1' R2' R18 m.p.( C) CH3 H C2H5 CO2CH3 CH3 CH3 C2H5 Br CH3 CH3 C2H5 CO2CH(CH3)2 CH3 CH3 C2H5 NO2 CH3 CH3 C2H5 H CH3 CH3 C2H5 Cl CH3 CH3 C2H5 Cl CH3 CH3 C2H5 CO2CH2CH=CH2 CH3 CH3 C2H5 CO2CH2CH2Cl CH3 CH3 C2H5 CO2CH3 CH3 CH3 C2H5 SO2CH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 OCH3 CH3 CH3 C2H5 SO2N(CH3)2 CH3 CH3 C2H5 NO2 CH3 CH3 C2H5 S02N(CH3)0CH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 SO2CH3 CH3 02H5 CH3 Br CH3 CH3 C2H5 Br CH3 CH3 C2H5 Cl CH3 C2H5 C2H5 Br CH3 C2H5 C2H5 CO2CH3 H C2H5 C2H5 SO2CH3 H C2H5 C2H5 SO2N(CH3)C2H5 Table 16 (continued) R' R1' R2' R18 m.p.( C) H CH3 C2H5 SO2(CH2)2CH3 H C2H5 CH3 SCH3 H C2H5 C2H5 SO2CH3 H C2H5 C2H5 CO2CH3 H C2H5 C2H5 H H CH3 C2H5 H H CH3 C2H5 H H C2H5 C2H5 SO2N(CH3)2 H C2H5 C2H5 Br H CH3 C2H5 F H C2H5 C2H5 F H SCH3 CH3 Br H SCH3 CH3 Br H SCH3 CH3 Br H SCH3 CH3 H H SCH3 CH3 Cl H SCH3 CH3 NO2 H SCH3 CH3 SO2N(CH3)C2H5 H SCH3 CH3 SO2N(CH3)[CH(CH3)2] CH3 SCH3 CH3 F CH3 SCH3 CH3 H CH3 SCH3 CH3 H CH3 SCH3 CH3 H CH3 SCH3 CH3 SO2CH3 CH3 SCH3 CH3 CO2CH3 CH3 SCH3 CH3 SO2N(CH3)2 CH3 SCH3 CH3 OC2H5 CH3 SCH3 CH3 H CH3 SCH3 CH3 CO2(CH2)3CH3 CH3 SCH3 CH3 CO2CH2CH2OCH3 CH3 SCH3 CH3 H Table 16 (continued) R1' R2' R18 m.p.( C) CH3 SCH3 CH3 OCH(CH3)C2H5 CH3 SCH3 CH3 CH3 CH3 SCH3 CH3 SCH3 CH3 SCH3 CH3 S(CH2)3CH3 CH3 SCH3 C2H5 SO2C2H5 CH3 SCH3 CH3 CO2CH(CH3)2 CH3 SCH3 CH3 CO2CH2CH=CH2 CH3 SCH3 C2H5 CO2CH3 CH3 SCH3 C2H5 Br CH3 SCH3 C2H5 SO2CH3 CH3 SCH3 C2H5 Cl CH3 SCH3 C2H5 NO2 H OCH3 CH3 CO2CH3 H OCH3 CH3 SO2N(CH3)C2H5 H OCH3 CH3 Br H OCH3 CH3 Cl H OCH3 CH3 NO2 H OCH3 CH3 SO2CH3 H OCH3 CH3 SO2CH3 H OCH3 CH3 SO2CH3 H OCH3 CH3 SO2(CH2)2CH3 H OCH3 CH3 OCH3 H OC2H5 CH3 O(CH2)3CH3 H OC2H5 CH3 CO2CH2CH=CH2 H OCH3 CH3 CO2CH2CH2Cl H OCH3 C2H5 CO2CH(CH3)2 H OCH3 C2H5 CO2(CH2)2CH3 H OC2H5 CH3 CO2C2H5 H OCH3 C2H5 CO2CH3 H OCH3 C2H5 Cl H OC2H5 CH3 Br Table 16 (continued) R' R1' R2' R18 m.p.( C) H OCH3 C2H5 SO2CH3 H OCH3 C2H5 SO2(CH2)3CH3 CH3 OCH3 C2H5 SO2CH2CH(CH3)2 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 OC2H5 CH3 OCH3 C2H5 F CH3 OCH3 C2H5 F CH3 OCH3 C2H5 SC2H5 CH3 OC2H5 CH3 SO2N(OCH3)CH3 CH3 OC2H5 CH3 SO2N(CH3)[(CH2)2CH3] CH3 OC2H5 CH3 H CH3 OC2H5 CH3 NO2 CH3 OC2H5 CH3 CO2CH(CH3)2 CH3 OC2H5 CH3 CO2CH2CH=CH2 CH3 OC2H5 CH3 CO2CH2CH2Cl CH3 OC2H5 CH3 CH3 CH3 OC2H5 CH3 CH(CH3)2 CH3 OC2H5 CH3 CH2CH(CH3)2 CH3 OC2H5 CH3 CH3 CH3 OC2H5 CH3 SO2CH3 CH3 OC2H5 CH3 Cl CH3 OC2H5 CH3 C2H5 CH3 OC2H5 CH3 NO2 CH3 OC2H5 CH3 Br CH3 OC2H5 CH3 Cl CH3 OC2H5 C2H5 Cl CH3 OC2H5 C2H5 CO2CH3 CH3 OC2H5 C2H5 SO2CH3 CH3 OC2H5 C2H5 SO2N(CH3)2 Table 16 (continued) R' R1' R2' R18 m.p.( C) H OC2H5 C2H5 NO2 H OC2H5 C2H5 Br H OC2H5 C2H5 CO2CH(CH3)2 H OCH3 C2H5 SO2C2H5 H OCH3 C2H5 F H OC2H5 CH3 OCH(CH3)2 H OC2H5 CH3 SO2(CH2)2CH3 H OC2H5 CH3 SO2CH(CH3)2 H OC2H5 CH3 SO2N(C2H5)2 Table 17 EMI190.1 R' R1' R2' R18 m.p.( C) CH3 H C2H5 CO2CH3 CH3 CH3 C2H5 Br CH3 CH3 C2H5 CO2CH(CH3)2 CH3 CH3 C2H5 NO2 CH3 CH3 C2H5 H CH3 CH3 C2H5 Cl CH3 CH3 C2H5 Cl CH3 CH3 C2H5 CO2CH2CH=CH2 CH3 CH3 C2H5 CO2CH2CH2Cl CH3 CH3 C2H5 CO2CH3 CH3 CH3 C2H5 SO2CH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 OCH3 CH3 CH3 C2H5 SO2N(CH3)2 CH3 CH3 C2H5 NO2 CH3 CH3 C2H5 SO2N(CH3)OCH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 SO2CH3 CH3 C2H5 CH3 Br CH3 CH3 C2H5 Br CH3 CH3 C2H5 Cl CH3 C2H5 C2H5 Br CH3 C2H5 C2H5 CO2CH3 H C2H5 C2H5 SO2CH3 H C2H5 C2H5 SO2N(CH3)C2H5 Table 17 (continued) R' R1' R2' R18 m.p.( C) H CH3 C2H5 SO2(CH2)2CH3 H C2H5 CH3 SCH3 H C2H5 C2H5 SO2CH3 H C2H5 C2H5 CO2CH3 H C2H5 C2H5 H H CH3 C2H5 H H CH3 C2H5 H H C2H5 C2H5 SO2N(CH3)2 H C2H5 C2H5 Br H CH3 C2H5 F H C2H5 C2H5 F H SCH3 CH3 Br H SCH3 CH3 Br H SCH3 CH3 Br H SCH3 CH3 H H SCH3 CH3 Cl H SCH3 CH3 NO2 H SCH3 CH3 SO2N(CH3)C2H5 H SCH3 CH3 SO2N(CH3)[CH(CH3)2] CH3 SCH3 CH3 F CH3 SCH3 CH3 H CH3 SCH3 CH3 H CH3 SCH3 CH3 H CH3 SCH3 CH3 SO2CH3 CH3 SCH3 CH3 CO2CH3 CH3 SCH3 CH3 SO2N(CH3)2 CH3 SCH3 CH3 OC2H5 CH3 SCH3 CH3 H CH3 SCH3 CH3 CO2(CH2)3CH3 CH3 SCH3 CH3 CO2CH2CH2OCH3 CH3 SCH3 CH3 H Table 17 (continued) R1' R2' R18 m.p.( C) CH3 SCH3 CH3 OCH(CH3)C2H5 CH3 SCH3 CH3 CH3 CH3 SCH3 CH3 SCH3 CH3 SCH3 CH3 S(CH2)3CH3 CH3 SCH3 C2H5 SO2C2H5 CH3 SCH3 CH3 CO2CH(CH3)2 CH3 SCH3 CH3 CO2CH2CH=CH2 CH3 SCH3 C2H5 CO2CH3 CH3 SCH3 C2H5 Br CH3 SCH3 C2H5 SO2CH3 CH3 SCH3 C2H5 Cl CH3 SCH3 C2H5 NO2 H OCH3 CH3 CO2CH3 H OCH3 CH3 502N(CH3)C2H5 H OCH3 CH3 Br H OCH3 CH3 Cl H OCH3 CH3 NO2 H OCH3 CH3 SO2CH3 H OCH3 CH3 502CH3 H OCH3 CH3 502CH3 H OCH3 CH3 SO2(CH2)2CH3 H OCH3 CH3 OCH3 H OC2H5 CH3 O(CH2)3CH3 H OC2H5 CH3 CO2CH2CH=CH2 H OCH3 CH3 CO2CH2CH2Cl H OCH3 C2H5 CO2CH(CH3)2 H OCH3 C2H5 CO2(CH2)2CH3 H OC2H5 CH3 C02C2H5 H OCH3 C2H5 CO2CH3 H OCH3 C2H5 Cl H OCH3 CH3 Br Table 17 (continued) R' R1' R2' R18 m.p.( C) H OCH3 C2H5 SO2CH3 H OCH3 C2H5 SO2(CH2)3CH3 CH3 OCH3 C2H5 SO2CH2CH(CH3)2 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 OC2H5 CH3 OCH3 C2H5 F CH3 OCH3 C2H5 F CH3 OCH3 C2H5 SC2H5 CH3 OC2H5 CH3 SO2N(OCH3)CH3 CH3 OC2H5 CH3 SO2N(CH3)[(CH2)2CH3] CH3 OC2H5 CH3 H CH3 OC2H5 CH3 NO2 CH3 OC2H5 CH3 CO2CH(CH3)2 CH3 OC2H5 CH3 CO2CH2CH=CH2 CH3 OC2H5 CH3 CO2CH2CH2Cl CH3 OC2H5 CH3 CH3 CH3 OC2H5 CH3 CH(CH3)2 CH3 OC2H5 CH3 CH2CH(CH3)2 CH3 OC2H5 CH3 CH3 CH3 OC2H5 CH3 SO2CH3 CH3 OC2H5 CH3 Cl CH3 OC2H5 CH3 C2H5 CH3 OC2H5 CH3 NO2 CH3 OC2H5 CH3 Br CH3 OC2H5 CH3 Cl CH3 OC2H5 C2H5 Cl CH3 OC2H5 C2H5 CO2CH3 CH3 OC2H5 C2H5 SO2CH3 CH3 OC2H5 C2H5 SO2N(CH3)2 Table 17 (continued) R1' R2' R18 m.p.( C) H OC2H5 C2H5 N02 H OC2H5 ' C2H5 Br H OC2H5 C2H5 CO2CH(CH3)2 H OCH3 02H5 SO2C2H5 H OCH3 C2H5 F H OC2H5 CH3 OCH(CH3)2 CH3 OC2H5 CH3 SO2(CH2)2CH3 CH3 OC2H5 CH3 SO2CH(CH3)2 CH3 OC2H5 CH3 SO2N(C2H5)2 Table 18 EMI195.1 R' R1' R2' R14 m.p.( C) CH3 H C2H5 Br CH3 CH3 C2H5 F CH3 C2H5 CH3 H CH3 C2H5 CH3 NO2 CH3 C2H5 CH3 CH3 CH3 CH3 C2H5 Cl CH3 CH3 C2H5 NO2 CH3 CH3 C2H5 NO2 CH3 C2H5 CH3 Cl CH3 C2H5 CH3 NO2 CH3 C2H5 CH3 Cl CH3 CH3 CH3 F CH3 C2H5 C2H5 H CH3 C2H5 CH3 SO2N(CH3)2 CH3 CH3 C2H5 SO2CH3 CH3 CH3 C2H5 SO2(CH2)CH3 H C2H5 C2H5 SO2C2H5 H C2H5 C2H5 OSO2CH3 H C2H5 C2H5 N02 H C2H5 C2H5 Cl H CH3 C2H5 SO2N(Ch3)C2H5 H CH3 C2H5 H H CH3 C2H5 H H CH3 C2H5 NO2 Table 18 (continued) R' R1' R2' R14 m.p.( C) H CH3 CH3 CH3 H SCH3 CH3 H H SCH3 CH3 N02 H SCH3 CH3 Cl H SCH3 CH3 H H SCH3 CH3 NO2 H SCH3 CH3 Cl H SCH3 CH3 OCH3 H SCH3 CH3 CH3 H SCH3 CH3 F H SCH3 CH3 H H SCH3 CH3 Cl H SCH3 CH3 N02 H SCH3 C2H5 CH3 H SCH3 C2H5 N02 H SCH3 C2H5 H CH3 SCH3 C2H5 OSO2CHCl2 CH3 SCH3 CH3 OSO2CH2CHFCl CH3 SCH3 CH3 OSO2CH(CH3)CH2F CH3 SCH3 CH3 OSO2(CH2)3Br CH3 SCH3 CH3 OSO2(CH2)2CHCl2 CH3 CH3 C2H5 OSO2CF3 CH3 CH3 C2H5 OSO2CF2CH2F CH3 C2H5 C2H5 OSO2CH2CF3 CH3 SCH3 C2H5 OSO2CHF2 CH3 CH3 C2H5 OSO2CCl3 CH3 SCH3 CH3 F H OCH3 C2H5 H H OCH3 C2H5 H H OCH3 CH3 H H OCH3 CH3 Cl Table 18 (continued) R' R1' R2' R14 m.p.( C) H OCH3 C2H5 SO2N(CH3)]CH(CH3)2] H OCH3 C2H5 SO2N(CH3)[(CH2)2CH3] H OCH3 C2H5 SO2N(CH3)2 H OCH3 CH3 OSO2(CH2)2CHCl2 H OCH3 CH3 OSO2CH(CH3)CHF2 H OCH3 CH3 OSO2CHFCF3 H OC2H5 CH3 Br H OC2H5 CH3 Cl H OC2H5 CH3 H H OC2H5 CH3 H H OC2H5 CH3 N02 H OC2H5 CH3 SCH3 H OC2H5 CH3 SCH2CH(CH3)2 H OC2H5 CH3 S(CH2)3CH3 H OCH3 C 2H5 S(CH2)2CH3 H OCH3 C2H5 SC2H5 H OCH3 C2H5 SO2CH2CH(CH3)2 CH3 OCH3 C2H5 SO2CH(CH3)2 CH3 OCH3 C2H5 SO2CH3 CH3 OCH3 C2H5 SO2(CH2)2CH3 H OCH3 C2H5 OSO2CH2CH2OCH3 H OC2H5 CH3 OSO2(CH2)3OCH3 H SCH3 CH3 OSO2(CH2)3CH3 H SCH3 CH3 Br H SCH3 CH3 Br H SCH3 CH3 H H SCH3 CH3 H H SCH3 CH3 502CH3 H SCH3 CH3 SO2C2H5 H OC2H5 CH3 Cl H OC2H5 CH3 NO2 Table 18 (continued) R' R1' R2' R14 m.p.( C) H C2H5 C2H5 H H SCH3 CH3 Cl H OC2H5 CH3 OS02CH2C1 H OC2H5 CH3 SO2CH3 H OC2H5 CH3 SO2(CH2)2CH3 H OC2H5 CH3 SCH3 H OC2H5 CH3 OSO2CF3 H OC2H5 CH3 SO2N(CH3)[(CH2)2CH3] H CH3 CH3 SG2N(OCH3)CH3 H OCH3 CH3 SO2N(OCH3)CH3 H SCH3 CH3 SO2N(OCH3)CH3 CH3 CH3 CH3 SO2N(OCH3)CH3 CH3 OCH3 CH3 SO2N(OCH3)CH3 CH3 SCH3 CH3 SO2N(OCH3)CH3 Formulations Useful formulations of the compounds of Formula I can be prepared in conventional ways They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1S to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions: Table 19 Weight Percent* Active Ingredient Diluent(s) Surfactant(s) Wettable Powders 20-90 0-74 1-10 Oil Suspensions, 3-50 40-95 0-15 Emulsions, Solutions, (including Emulsifiable Concentrates) Aqueous Suspension 10-50 40-84 1-20 Dusts 1-25 ' 70-99 0-5 Granules and Pellets 0.1-95 5-99.9 0-15 High Strength 90-99 0-10 0-2 Compositions * Active ingredient plus at least one of a Surfactant or a Diluent equals 100 weight percent. Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing. Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, New Jersey, but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York, 1950. Solubility under û.l% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at OOC. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, New Jersey, as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc. The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Patent 3,060,084). Granules and pellets may be made b spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, December 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff. For further information regarding the art of formulation, see for example: H. M. Loux, U.S. Patent 3,235,361, February 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41; R. W. Luckenbaugh, U.S. Patent 3,309,192, March 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; H. Gysin and E. Knusli, U.S. Patent 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; G. C. Klingman, "Weed Control as a Science", John Wiley & Sons, Inc., New York, 1961, pp. 81-96; and 3. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103. In the following examples, all parts are by weight unless otherwise indicated. Example XI Wettable Powder 2-Er(1-methyl-5-methylthio-lH-1,2,4-triazol-3-yl)- aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester 80S sodium alkylnaphthalenesulfonate 2% sodium ligninsulfonate 2% synthetic amorphous silica 3% kaolinite 13% The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged. Example XII Wettable Powder 2-Ec(5-ethylthio-1-methyl-lH-1,2,4-triazol-3-yl)- aminocarbonyl]aminosulfonyl]benzoic acid , methyl ester 50% sodium alkylnaphthalenesulfonate 2% low viscosity methyl cellulose 2% diatomaceous earth 46% The ingredients are blended, coarsely hammermilled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging. Example XIII Granule Wettable Powder of Example XII 5% attapulgite granules 95% (U.S.S. 20-40 mesh; 0.84-0.42 mm) A slurry of wettable powder containing X25% salids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged. Example XIV Extruded Pellet 2-E[(5-ethyl-1-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl3aminosulfonyl)benzoic acid, methyl ester 25E anhydrous sodium sulfate 10% crude calcium ligninsulfonate 5% sodium alkylnashthalenesulfonate 1% calcium/magnesium bentonite 59% The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which a cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled. Example XV Oil Suspension 2-[[(5-methoxy-1-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl)aminosulfonyl)benzoic acid, methyl ester 25% polyoxyethylene sorbitol hexaoleate 5% highly aliphatic hydrocarbon oil 70% The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water. Example XVI Wettable Powder N-[(5-methoxy-1-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl)-2-chlorobenzenesulfonamide 20% sodium alkylnaphthalenesulfonate 4% sodium ligninsulfonate 4% low viscosity methoxy cellulose 3% attapulgite 69% The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.5. No. 50 sieve (0.3 mm opening) and packaged. Example XV1I Low Strength Granule N;t(5-methoxy-1-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl)-N' ,N'-dimethyl-1,2-benzenedisulfon- amide 1% N,N-dimethylformamide 9% attapulgite granules 90% (U.S.S. 20-40 sieve) The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged. Example XVIII Aqueous Suspension 2-[t(5-methylthio-1-methyl-lH-1,2,4-triazol-3-yl)- aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester 40% polyacrylic acid thickener 0.3% dodecylphenol polyethylene glycol ether 0.5S disodium phosphate 1% monosodium phosphate 0.5two polyvinyl alcohol 1.0S water 56.7% The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size. Example XIX Solution 2-t[(5-ethyl-l-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl]aminosulfonyl]benzoic acid, methyl ester, sodium salt 5% water 95S The salt is added directly to the water with stirring to produce the solution, which may then be packaged for use. Example XX Low Strength Granule 2-[C(5-ethylthio-1-methyl-lH-1,2,4-triazol-3-yl)- aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester 0.1% attapulgite granules 99.9% (U.S.S. 20-40 mesh) The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged. Example XXI Granule 2-[ [(5-methoxy-l-methyl-1K-l,2,4-triazol3y1)amino carbonyl]aminosulfonyl]benzoic acid, methyl ester 80% wetting agent 1% crude ligninsulfonate salt (containing 10% 5-20% of the natural sugars) attapulgite clay 9% The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use. Example XXII High Strength Concentrate N-[(5-methoxy-1-methyl-lH-1,2,4-triazol-3 yl)amino- carbonyl)-2-chlorobenzenesulfonamide 99% silica aerogel 0.5X synthetic amorphous silica 0.5% The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary. Example XXIII Wettable Powder N-E(5-methoxy-1-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl]-N',N'-dimethyl-1,2-benzenedisulfon- amide 90% dioctyl sodium sulfosuccinate 0.1% synthetic fine silica 9.9% The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged. Example XXIV Wettable Powder 2-[E(5-methylthio-1-methyl-lH-1}2,4-triazol-3-yl)amino- carbonylaaminosulfonylzbenzzic acid, methyl ester 40 > sodium ligninsulfonate 20S montmorillonite clay 40% The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged. Example XXV Oil Suspension 2-EC(5-ethylthio-1-methyl-lH-1,2,4-triazol-3-yl)amino- carbonyl]aminosulfonyl]benzoic acid, methyl ester 35S blend of polyalcohol carboxylic 6% esters and oil soluble petroleum sul fonates xylene 59% The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water. Example XXVI Dust 2-EE(5-ethyl-1-methyl-lH-1,24-triazol-3-yl)amino- carbonyl]aminosulfonyl]benzoic acid, methyl ester 10% attapulgite 10% Pyrophyllite 80% The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous. Utility The compounds of the present invention have herbicidal activity. They have utility for broad-spectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. In addition, some of the compounds are useful for the selective control of weeds in certain crops, including wheat and soybeans. The rates of application for the compounds of the invention are determined by a number of factors, including their use as selective or general herbicides, the crop species involved, the types of weeds to be controlled, weather conditions, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.125 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, or for situations where only short-term persistence is required. The compounds of the invention may be used in combination with any other commercial herbicide, examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium types. The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow. Test A Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloa crusgalli), wild oats (Avena fatua), cassia (Oassia tora), morningglory (Ipomoea sp.), cocklebur (Xanthium sp.), sorghum, corn, soy- bean, rice, wheat and nutsedge tubers (Cyperus rotundus) were planted in a growth medium and treated pre-emergence with the chemicals dissolved in a nonphytotoxic solvent. At the same time, cotton having five leaves (including cotyledonary ones), bush beans with the third trifoliate leaf expanding, crabgrass, barnyardgrass and wild oats with two leaves, cassia with three leaves (including cotyledonary ones), morningglory and cocklebur with four leaves (including the cotyledonary ones), sorghum and corn with four leaves, soybean with two cotyledonary leaves, rice with three leaves, wheat with one leaf, and nutsedge with three to five leaves were sprayed. Treated plants and controls were maintained in a greenhouse for sixteen days, whereupon all species were compared to controls and visually rated for response to treatment. The ratings are based on a numerical scale extending from 0 = no injury, to 10 = complete kill. The accompanying descriptive symbols have the following meanings: A = growth acceleration; C = chlorosis or necrosis; E = emergence inhibition; G = growth retardation; H = formative effects; P = terminal bud injury; U = unusual pigmentation; X = axillary stimulation; and 6Y = abscised buds or flowers. The ratings for the compounds tested by this procedure are presented in Table A. The compounds tested demonstrate good control of nutsedge, espe- cially in pre-emergence application. The results show one compound to be relatively tolerant to soybeans, and a few to be tolerant to wheat. Table A Structures Compound 1 EMI211.1 Compound 2 EMI211.2 Compound 3 EMI211.3 Compound 4 EMI211.4 Table A Structures (continued) Compound 5 EMI212.1 Compound 6 EMI212.2 Compound 7 EMI212.3 Compound 8 EMI212.4 Table A Structures (continued) Compound 9 EMI213.1 Compound 10 EMI213.2 Compound 11 EMI213.3 Compound 12 EMI213.4 Table A Structures (continued) Compound 13 EMI214.1 Compound. 14 EMI214.2 Compound 15 EMI214.3 Compound 16 EMI214.4 Table A Structures (continued) Compound 17 EMI215.1 Compound 18 EMI215.2 Compound 19 EMI215.3 Compound 20 EMI215.4 Table A Structures (continued) Compound 21 EMI216.1 Compound 22 EMI216.2 Compound 23 EMI216.3 Compound 24 EMI216.4 Table A Structures (continued) Compound 25 EMI217.1 Compound 26 EMI217.2 Compound 27 EMI217.3 Compound 28 EMI217.4 Table A Structures (continued) Compound 29 EMI218.1 Compound 30 EMI218.2 Compound 31 EMI218.3 Compound 32 EMI218.4 Compound 33 EMI218.5 Table A Structures (continued) Compound 34 EMI219.1 Table A Compound 1 Compound 2 Rate kg/ha 0.4 .05 0.4 .05 POST-EMERGENCE Bush bean 90 5C,9G,6Y 5C,9G,6Y 5C,9G,6Y Cotton 5C,9G 2C,9G 4C,9G 4C,8G Morningglory 5C,9G 9C 5C,9G 4C,8H Cocklebur 10C 9C 9C 3G Cassia 9C 9C 5C,9G 3C,8G Nutsedge 9C 10C 4C,9G 2C,8G Crabgrass 9C 9C 5C,9G 2C,8G Barnyardgrass 9C 9C 9C 9C Wild Oats 9C 9C 2C,9G 2C,8G Wheat 9C 9C 2C,9G 5G Corn 100 90 5U,9C 90 Soybean 9C 9C 5C,9G 4C,9G Rice 9C 9C 5C,9G 5C,9G Sorghum 90 90 4C,9G 4C,9G Sugar beet 90 90 90 5C,9G PRE-EMERGENCE Morningglory 9C 9G 9G 2C,8H Cocklebur 9H 9H 9H 8H Cassia 9C 3C,9G 2C,9G 2C,7G Nutsedge 10E 10E 5C,9G 2C,7G Crabgrass 6C,9G 5C,9G 3C,7G 2C,3G Barnyardgrass 10E 6C,9H 5C,9H 3C,8H Wild Oats 6C,9H 6C,9H 4C,9G 2C,7G Wheat 6C,9H 6C,9H 9H 2C,8G Corn 10E 10H 10H 3C,9H Soybean 9H 3C,8H 9H 3C,4H Rice 10E 10E 10E 10E Sorghum 6C,9H 5C,9H 6C,9H 5C,9H Sugar beet 10E 10E 6C,9G 5C,9G Table A (continued) Compound 3 Compound 4 Rate kg/ha 0.4 .05 0.4 .05 POST-EMERGENCE Bush bean 5C,9G,6Y 4C,9G,6Y 9C 5C,9G,6Y Cotton 5C,5H 3C,3G 6C,9G 4C,8G Morningglory 4C,9G 4C,8H 9C 5C,9G Cocklebur 2C,8G 1C,4G 9C 9C Cassia 4C,8H 2C,5G 5C,9G 4C,8H Nutsedge 2C,9G 2C,5G 9C 2C,9G Crabgrass 3C,9G 2C,3G 9C 9C Barnyardgrass 9C 5C,8H 9C 9C Wild Oats 4C,9G 2C,3G 9C 9C Wheat 5C,9G 2C,8G 9C 9C Corn 5U,9C 2C,9H 10C 9C Soybean 5C,9G 3C,8G 9C 9C Rice 6C,9G 5C,9G 9C 9C Sorghum 3C,9G 4C,8H 9C 5C,9G Sugar beet 5C,9G 2C,5G 9C 5C,9G PRE-EMERGENCE Morningglory 4C,8H 1C 9C 2C,9G Cocklebur 4G 0 9H 9H Cassia 1C 1C 2C,8G 3C,8G Nutsedge 2C,6G 0 10E 5C,9G Crabgrass 2G 0 6C,9G 1C,3G Barnyardgrass 3C,6G 1C 10H 5C,9H Wild Oats 3C,6G 1C 6C,9H 6C,9H Wheat 2C,9G 2G 7C,9H 10H Corn 3C,9H 2C,3G 10H 5C,9H Soybean 2C,3G 1C 9H 4C,6H Rice 5C,8H 3C 10E 10E Sorghum 4C,9H 3G 6C,9H 6C,9H Sugar beet 1C 0 6C,9G 5C,9G Table A (continued) Cmpd. 5 Cmpd. 6 Cmpd. 7 Cmpd. 8 Rate kg/ha 0.1 0.1 0.1 0.1 POST-EMERGENCE Bush bean 90 2H 2C,9G,6Y 4C,9G,6Y Cotton 5C,9G 0 1C 1C,1H Morningglory 2C,8G 0 1C,4H 4H Cocklebur 8G 0 2G 3C,9G Cassia 3C,5G 0 20 0 Nutsedge 9C,9G 0 1C,4G 0 Crabgrass 3C,8G 0 1C,3G 2C Barnyardgrass 5c,9H 2H 5C,9H 2C,8H Wild Oats 1C,9G 0 0 0 Wheat 9G 0 0 0 Corn 3U,9H 4G 1C,5G 2C,8H Soybean 6C,9G 2H 2C,9G,5X 1C,3G Rice 6C,9G 5G 2C,9G 6G Sorghum 7U,9G 5G 2C,8H 2C,8H Sugar beet - - - PRE-EMERGENCE Morningglory 9G 0 20 0 Cocklebur 9H O 1C 4G Cassia 2C,8G 0 20 3H Nutsedge 10E O 3G O Crabgrass 2C,4G 0 1C 0 Barnyardgrass 3C,9G O 1C 0 Wild Oats 2C,9G 0 0 0 Wheat 2C,9G 0 0 0 Corn 1C,9G 0 2C,6G 1C,7H Soybean 3C,8G 0 2C,3H 2A Rice lOE 0 6G 2C,7H Sorghum 3C,9H 0 2C,6G 2C,6G Sugar beet - - - Table A (continued) Cmpd. 9 Cmpd. 10 Cmpd. 11 Cmpd. 12 Rate kg/ha 0.1 0.1 .05 .05 POST-EMERGENCE Bush bean 90 90 6C,9G,6Y 0 Cotton 5C,8H 5C,9G 4C,8G 0 Morningglory 5C,9H 3C,9G 2C 0 Cocklebur 2C,8G 8H 1C 0 Cassia 5C,8G 5C,8H 1C 0 Nutsedge 2C,7G 7C,9G 3C,6G 0 Crabgrass 9C 9C 2C 0 Barnyardgrass 9C 10C 3C,7H 0 Wild Oats 1C,9G 9C 1C 0 Wheat 90 90 0 0 Corn 9C 10C 2C,4H 0 Soybean 5C,9G 6C,9G 4C,9G 4H Rice 5C,9G 10C 4C,9G 0 Sorghum 50,90 100 20,90 0 Sugar beet - - PRE-EMERGENCE Morningglory 90 8H 30 0 Cocklebur 9H 9H 9H Cassia 8G 3C,7G 2C 2C Nutsedge 9G 10E 1C,4G 0 Crabgrass 2C,3G 3C,5G 1C,2H 0 Barnyardgrass 5C,9H 3C,9H 2C 0 Wild Oats 2C,8G 30,90 20 0 Wheat 9H 20,90 2G 0 Corn 2C,9G 3C,9G 3C,7H 0 Soybean 9H 3C,7H 2C,5H 0 Rice 10E 10E 5C,7G 5G Sorghum 2C,9H 4C,9H 3C,9H 0 Sugar beet - - - Table A (continued) Cmpd. 13 Cmpd. 14 Cmpd. 15 Cmpd. 16 Rate kg/ha .05 .05 .05 .05 POST-EMERGENCE Bush bean 4C,9G,6Y 3C,8G,6Y 0 4C,8G,6Y Cotton 2C,6G 2C 0 4C,7H Morningglory 2C,5G 1C 0 2C,6G Cocklebur 2C,8H 5G 5H 2G Cassia 1C 3G 0 1C Nutsedge 0 0 0 0 Crabgrass 0 0 0 0 Barnyardgrass 0 0 0 5H Wild Oats O 0 0 0 Wheat O 0 0 0 Corn O 0 0 20 Soybean 2C,6H 2C,6G 2G 2C,9G,5X Rice 6G 2G 0 4C,8G Sorghum 20 0 0 3C,8H Sugar beet PRE-EMERGENCE Morningglory 3C,5G 1C O O Cocklebur 70 - 0 Cassia O 0 0 0 Nutsedge 80 0 0 0 Crabgrass 0 0 0 0 Barnyardgrass 1C 1C 0 3C Wild Oats O 0 0 0 Wheat O 0 0 0 Corn 20,50 20 0 20 Soybean 1C 0 2H 1C Rice 2C 0 2G 1C Sorghum 1C O O 1C Sugar beet - - - Table A (continued) Cmpd. 17 Cmpd. 18 Cmpd. 19 Cmpd 20 Rate kg/ha .05 1/20 1/20 1/20 POST-EMERGENCE Bush bean 1C 9C 5C,9G,6Y 4C,9G,6Y Cotton 1C 4C,8H 5C,8G 4C,5H Morningglory 1C 4C,8H 4C,7G 5C,8H Cocklebur 0 5C,9G 9C 9C Cassia 1C 4C,7H 3C,6H 3C,3G Nutsedge 0 2C,8G 3C,9G 2C,7G Crabgrass 0 2C,5G 3C,7G 3C,8G Barnyardgrass 1C 9C 9C 9C Wild Oats 0 3C,9G 0 1C Wheat 0 3C,9G 0 7G Corn 1C 3C,9H 5C,9G 2C,9G Soybean 1C 5C,9G 6C,9G 1C,2H Rice 0 5C,9G 5C,9G 5C,9G Sorghum 2C 3U,9G 2C,9G 4C,9G Sugar beet - 9C 50,90 90 PRE-EMERGENCE Morningglory 0 2C,8H 2C,8H 4C,8H Cocklebur 0 8H 10E 9H Cassia 0 3C,6G 9G 2C,3G Nutsedge 0 10E 4C,9G 2C,9G Crabgrass 0 2C,3G 2C 3C,6G Barnyardgrass 0 3C,8H 3C,8H 5C,9H Wild Oats 0 2C,6G 5G 2C,4G Wheat 0 2C,8H 6G 3C,7G Corn 1C 5C,9H 5C,9G 5C,9H Soybean 0 3C,5H 3C,7G 0 Rice 0 10E 10E 10E Sorghum 0 5C,8H 2C,9G 5C,9H Sugar beet - 5C,9G 9C 5C,9G Table A (continued) Cmpd. 21 Cmpd. 22 Cmpd. 23 Cmpd. 23 Rate kg/ha 1/20 1/20 1/20 2/5 POST-EMERGENCE Bush bean 0 3C,8G,6Y 90 90 Cotton 2C 3C,4H 4C,9G 5C,9G Morningglory 2C,5G 3C,8G 4C,9G 5C,9G Cocklebur 1C 2C,6G 6G 5C,9G Cassia 1C 3C 3C,8G 3C,9G Nutsedge 0 3G 3C,8G 90 Crabgrass 0 3G 5C,9G 90 Barnyardgrass 2H 90 90 90 Wild Oats 0 3C,9G 90 90 Wheat 0 2C,6G 6U,9G 9C Corn 1C,3G 2C,5H 6U,9G 10C Soybean 1C 1C,3H 4C,9G 5C,9G Rice 0 5C,9G 3C,9G 5C,9G Sorghum 2C,5G 4C,9G 3U,9G 9C Sugar beet 2C,5G 4C,9H 90 9C PRE-EMERGENCE Morningglory 3C,3H 2C,6H 9C 9C Cocklebur - 1C - 9H Cassia 2C 0 5C,8G 5C,9G Nutsedge 0 0 9G 10E Crabgrass 3G lC,4G 5G 5C,9G Barnyardgrass 0 2C,6H 2C,4G 5C,9H Wild Oats 0 4G 4C,9G 5C,9H Wheat 0 0 4C,9H 10H Corn 0 3C,8H 5C,9H 10H Soybean 1H O 8H 9H Rice 20 4C,9H lOE lOE Sorghum 3C 4C,9H 5C,9H 6C,9H Sugar beet 9G 2C,4H 5C,9G 10E Table A (continued) Cmpd. 24 Cmpd. 24 Cmpd. 25 Cmpd. 25 Rate kg/ha 1/20 2/5 2/5 1/20 POST-EMERGENCE Bush bean 2C,7G,6Y 5C,9G 9C 4C,9G,6Y Cotton 3C,7G 5C,8G 4C,8G 4C,4H Morningglory 3C,7G 4C,9G 5C,9G 3C,8G Cocklebur 8G 2C,9G 7G 0 Cassia 3C,5H 3C,5H 5C,9G 3C,8G Nutsedge 4G 2C,7G 9C 3C,8G Crabgrass 3C,7G 5C,9G 9C 4C,9G Barnyardgrass 90 9C 9C 9C wild Oats 3C,9G 9C 2C,8G 4G Wheat 5C,9G 5U,9G 5U,9G 3U,9G Corn 2C,8H 3U,9G 9C 3U,9G Soybean 5C,9G 5C,9G 5C,9G 3C,9G Rice 5C,9G 5C,9G 5C,9G 5C,9G Sorghum 3C,9H 5C,9G 3U,9G 5C,9G Sugar beet 5C,8H 5C,9H 9C 9C PRE-EMERGENCE Morningglory 2C,3H 5C,9G 5C,9H 4C,9G Cocklebur 5H 9H 0 9H 9H Cassia 2C 5C,8G 5C,9G 4C,9G Nutsedge 0 2C,8G 10E 10E Crabgrass 0 3C,5G 6C,9G 4G Barnyardgrass 1C 3C,8H 5C,9H 5C,9H Wild Oats 0 4C,9H 3C,9G 4G Wheat 0 4C,9H 10H 3C,9H Corn 3C,8H 5C,9G 9H 4C,9H Soybean 1C,1H 3C,5H 8H 3C,3H Rice 2C,8G 10E 10E 10E Sorghum 3C,8H 5C,9H 5C9H 5C,9H Sugar beet 2C,5G 5C,9H 10E 10E Table A (continued) Cmpd. 26 Cmpd. 27 Cmpd. 27 Rate kg/ha 2/5 2/5 1/20 POST-EMERGENCE Bush bean 2C 5C,9G,6Y 4C,9G,6Y Cotton 1C 4C,8G 2C,3H Morningglory 2C,5G 4C,8G 2C,9G Cocklebur 1H 6G 5H Cassia 3G 4C,8G 3C,6H Nutsedge O 4C,9G 6G Crabgrass O 9C 2C,8G Barnyardgrass O 9C 9C Wild Dats O 9C 2C,5G Wheat O 3U,9G 2G Corn 2C,3H 9C 4C,9G Soybean 2C,2H 5C,9G 4C,9H Rice O 4C,9G 3C,9G Sorghum 2G 4U,9G 2C,9G Sugar beet O 4C,9H 4C,8H PRE-EMERGENCE Morninglory 2C 5C,9G 2C,9H Cocklebur O 9H 5H Cassia O 5C,9G 3H Nutsedge O 10E 2C,9G Crabgrass O 5C,9G 1C Barnyardgrass O 2C,8H O Wild Oats O 4C,9G O Wheat O 2C,9G O Corn O 10E 3C,8G Soybean O 2C,8H 1H,1A Rice O 10E 10E Sorghum O 5C,9H 2C,9G Sugar beet O 5C,9G 2C,7G Table A (continued) Cmpd. 28 Cmpd. 28 Cmpd. 29 Cmpd 30 Rate kg/ha 2/5 1/20 0.4 2 POST-EMERGENCE Bush bean 3C,8G,6C 4C,8G,6Y 9C 2S,9G,6Y Cotton 4C,7G 2C,2H 6C,9G 3C,8G Morningglory 4C,8G 4C,8H 2C,9G 3C,8G Cocklebur 3G 2G 9C 2C Cassia 2C,4H 1C,3G 4C,9G 2C Nutsedge 2C,9G 3G 9C 1C,7G Crabgrass 4C,9G 2C,7G 9C 1C,6G Barnyardgrass 9C 3C,8H 9C 2C,6H Wild Oats 1C,2G O 9C 2C,5G Wheat 3U,9G 3C,9G 5C,9G 2C,5G Corn 5C,9G 2C,9G 10C 3C Soybean 1C,2H 1C 4C,9G 3C,7G Rice 5C,9G 1C,4G 4C,9G 2C,9G Sorghum 5C,9G 3C,9G 10C 2C,6G Sugar beet 9C 3C,9H - PRE-EMERGENCE Morninglory 9G 2C,2H 9H 8G Cocklebour 9H 7H - 6G Cassia 2C,7G 1C 2C,9G 10E Nutsedge 5G O 10E 10E Crabgrass 3G 1C 4C,8G 5G Barnyardgrass 2C,6G 1C 5C,9H 2C,8H Wild Oets 1C O 5C,9G 2C WHeat 5C,9H O 9H 5G Corn 5C,9H 2C,8G 10H 2C,5G Soybean O O 9H 1C Rice 5C,9H 2C,5G 10E 9H Sorghum 5C,9H 3C,9H 10E 3C,8G Sugar beet 5C,9G 2C,7G - Table A (continued) Cmpd. 31 Cmpd. 32 Cmpd. 33 Cmpd. 34 Rate kg/ha 2/5 2/5 2/5 2 POST-EMERGENCE Bush bean 6C,9G,6Y 9C 90 3C,6Y Cotton 5C,9G 4C,4H,8G 6C,9G 1C Morningglory 10C 4C,9H 1C,3G 2C Cocklebur 9C 5G 9C 1C Cassia 4C,9G 2C,G 3C 1C Nutsedge 3C,9G 2C,9G 1C,9G 2G Crabgrass 2C,5G 4C,8G 1H 5 Barnyardgrass 9C 4C,7H 2C,9H 1C,4H Wild Oats 3C,9G 30 20 0 Wheat lC,9G 1C O 0 Corn 5C,9G 8H 2C,6H 20 Soybean 4C,9G 4C,9G 5C,9G 2C,5G Rice 5C,9G 6C,9G 6C,9G 2C,7G Sorghum 4U,9G 2C,9H 2C,9G 2C,8G Sugar beet - - - PRE-EMERGENCE Morningglory 9H 9G 8H 0 Cocklebur 9H 9H 9H 0 Cassia 3C,9G 2C,8G 8G O Nutsedge lOE lOE lOE 0 Carbgrass 3G 2C,6G 1C 5G Barnyardgrass 9H 3C,9H 2C,9H O Wild Oats 2C,9H 2C,8G 1C,9G 0 Wheat 2C,9H 0 lC,8G 0 Corn 2C,9G 9H 2C,9H 2C Soybean 9H 9H 8H O Rice 10E 9H 9H O Sorghum 9H 1,C5G 2C,8H O Sugar beet - - - 0 Test B Two plastic bulb pans were filled with fertilized and limed Fallsington silt loam soil. One pan was planted with corn, sorghum, Kentucky bluegrass and several grassy weeds. The other pan was planted with cotton, soybeans, purple nutsedge (Cyperus rotundus), and several broadleaf weeds. The following grassy and broadleaf weeds were planted: crabgrass (Digitaria sanguinalis), barnyardgrass (Echinochloa crusgalli), wild oats (Avena fatua), johnsongrass (Sorghum halepense), dallisgrass (Paspalum dilatatum), giant foxtail (Setaria faberii), cheatgrass (Bromus secalinus), mustard (Brassica arvensis), cocklebur (Xanthium pensylvanicum), pigweed (Amaranthus tetroflexus), morningglory (Ipomoea hederacea), cassia (Cassia tora), teaweed (Sida spinosa), velvetleaf (Abutilon theophrasti), and jimsonweed (Datura stramonium). A 12.5 cm diameter plastic pot was also filled with prepared soil and planted with rice and wheat. Another 12.5 cm pot was planted with sugarbeets. The above four containers were treated pre-emergence with several test compounds within the scope of the invention. Twenty-eight days after treatment, the plants were evaluated and visually rated for response to the chemical treatments utilizing the rating system described previously for Test A. The data are summarized in Table 8. Table B PRE-EMERGENCE ON WOODSTOWN SANDY LOAM Compound 1 Compound 2 Rate kg/ha 0.03 0.12 0.03 0.12 Crabgrass 9G,9C 9G,9C 7G 8G Barnyardgrass 9G,9C 9G,9C 6G 9G Sorghum 100 100 9G 100 Wild Oats 9G 9G 3G 7G Johnsongrass 9G 9G 7G 8G Dallisgrass 9G,9C 9G,9C 0 7G Giant foxtail 9G,9C 9G,9C 4G 9G Ky. bluegrass 9G,9C 9G,9C 7G 8G Cheatgrass 10C 10C 8G 10C Sugar beets 100 100 9G 10C Corn 9G 100 3G 9G Mustard 100 100 9G 100 Cocklebur 8G 9G 0 7G Pigweed w Nutsedge 100 100 9G 100 Cotton 8G 9G 3G 7G Morningglory 8G 9G 5G 7G Cassia 8G 9G 4G 8G Teaweed 8G 9G 3G 7G Velvetleaf 9G 9G 8G 8G Jimsonweed 9G,9C 9G,9C 6G 8G Soybean 9G 9G 5G,3C 7G,5C Rice 10C 10C 10C 10C Wheat 9G,9C 9G,9C 2G 5G Table B (continued) PRE-EMERGENCE ON WOODSTOWN SANDY LOAM Compound 3 Compound 4 Rate kg/ha 0.03 0.12 0.03 0.12 Crabgrass O 0 6G 9G Barnyardgrass O 0 6G 9G Sorghum 0 3G 100 100 Wild Oats 0 2G 6G 8G Johnsongrass 2G 5G 7G 8G Dallisgrass O O 7G 8G Giantfoxtail O O 9G 9G,9C Ky. bluegrass O O 8G 9G Cheatgrass 0 5G 9G 100 Sugar beets 5G 5G 8G 9G Corn 0 2G 2G 9G,9C Mustard 8G 8G 100 100 Cocklebur O O 8G 9G Pigweed - - - Nutsedge O 0 9G 9G Cotton O 0 2G 7G Morningglory O 2G 6G 8G Cassia O 0 0 3G Teaweed O 0 0 4G Velvetleaf O 0 5G 8G Jimsonweed 0 0 7G 8G Soybean O 0 2G,2C 7G,5C Rice 7G 9G 100 100 Wheat O 0 8G 9G Table B (continued) PRE-EMERGENCE ON WOODSTOWN SANDY LOAM Compound 5 Compound 9 Rate kg/ha 0.060 0.250 0.030 0.120 Crabgrass . 0 7G 4G 5G Barnyardgrass 4G 100 3G 7G,3C Sorghum 100 lOE - Wild Oats 0 6G,3H 3G 6G Jahnsongrass 8G,5H 10C 6G,3H 7G,3H Dallisgrass 7G 9G,9C 7G 8G Giant foxtail 2G 8G,8C O 4G Ky. bluegrass 8G 10E 7G,5C 10C Cheatgrass 70 100 7G,3C 70,70 Sugar beets 80,90 100 8G,7C 9G,9C Corn 4G 100 40 8G,5H Mustard 8G,8C 100 7G 8G Cocklebur 30 7G 5G 6G Pigweed 90,90 100 100 100 Nutsedge 80 lOE 6G 8G Cotton 3G,2C 8G,5H 3G,3H 9G,5H Morningglory 6G 9G,3H SG 9G Cassia 3G 7G,3H 6G 7G,3C Teaweed 40,30 8G,SH 3G 7G,3H Velvetleaf 6G,5H 90,90 4G 7G,5H Jimsonweed 60 9G,9C 20 50 Soybean 5G,5H 90,90 5G,3H 9G,5H Rice 100 100 lOE lOE Wheat 3G 60 2G 6G Table B (continued) PRE-EMERGENCE ON WOODSTOWN SANDY LOAM Compound 10 Compound 33 Rate kg/ha 0.030 0.120 0.50 Crabgrass O 5G O Barnyardgrass O 6G O Sorghum - - O Wild Oats O 6G O Johnsongrass 5G,3H 8G,3H 0 Dallisgrass 6G,3H 90,90 0 Giant foxtail 0 0 0 Ky. bluegrass 6G,3H 7G,5H 0 Cheatgrass 7G,5C 8G,5C O Sugar beats 3G 8G,8C O Corn 2G 90,90 0 Mustard 90,70 90,90 60 Cocklebur 5G - 6G Piqweed - - O Nutsedge 80 10E 4G Cotton 0 40 0 Morningglory 5G 7G,3H 0 Cassia 4G 6G O Teaweed O 6G,3H 9G,9C Velvetleaf O 5G,5H 0 Jimsonweed O 6G,3H O Soybean O 7G,5H 0 Rice 8G,5H lOE 0 Wheat O 7G,5H 0 Test C The test chemicals, dissolved in a non-phytotoxic solvent, were applied in an overall spray to the foliage and surrounding soil of selected plant species. One day after treatment, plants were observed for rapid burn injury. Approximately fourteen days after treatment, all species were visually compared to untreated controls and rated for response to treatment. The rating system was as described previously for Test A. The data are presented in Table C. All plant species were seeded in Woodstown sandy loam soil sand grown in a greenhouse. The following species were grown in soil contained in plastic pots (25 cm diameter by 13 cm deep): soybeans, cotton, alfalfa, corn, rice, wheat, sorghum, velvetleaf (Abutilon theophrasti), sesbania (Sesbania exaltata), Cassia (Cassia tora), morningglory (Ipomoea hederacea), jimsonweed (Datura stramonium), cocklebur (Xanthium pensylvanicum), crabgrass (Digitaria sp.), nutsedge (Cyperus rotundus), barnyardgrass (Echinochloa crusgalli), giant foxtail (Setaria faberii) and wild oats (Avena fatua). The following species were grown in soil in a paper cup (12 cm diameter by 13 cm deep): sunflower, sugarbeets, and mustard. All plants were sprayed approximately 14 days after planting. The compounds tested by this procedure are highly active post-emergence herbicides. Table C Over-the-Top Soil/Foliage Treatment Compound 1 Rate kg/ha 0.004 0.016 0.064 0.25 Soybeans 100 100 100 100 Velvetleaf 80 90,50 90 100 Sesbaniua 6G 9G 10G 10C Cassia 5G 9G 10G 10C Cotton 6G 9G 9G 10C Morningglory 80 90 100 100 Alfalfa 70 80 90 100 Jimsonweed 80 90 90 90 Cocklebur 80 80 80 10P Corn 90 90 100 100 Crabgrass 30 90 90 90 Rice 80 90 100 100 Nutsedge 90 90 100 100 Barnyardgrass 90 100 100 100 Wheat 40 80 90 90 Giant foxtail 9G 10C 10C 10C Wild Oats 8G 9G 9G 9G Sorghum 9U 9U 9G 10C Sunflower 9G,3H 10C 10C 10C Rape 8G 9G 9G 9G Johnsongrass 10U 10U 10C 10C Sugar beets 8G 10C 10C 10C Bindweed 8G 9G 9G 9G Table C (continued) Over-the-Top Soil/Foliage Treatment Compound 2 Rate kg/ha 0.016 0.064 0.25 Soybeans 80 90,40 100 Velvetleaf 80 90 90 Sesbania 60 9G 100 Cassia 40 70 80 Cotton 60 80 80 Morningglory . 6G 70 90 Alfalfa 30 60 8G Jimsonweed 30 60 80 Cocklebur 40 5G 80 Corn 90 90 90 Crabgrass 0 60 80 Rice 90 90 90 Nutsedge 40 80 100 Barnyardgrass 90 100 100 Wheat 0 40 90 Giant foxtail 70 90 90 Wild Oats 0 70 90 Sorghum 70 90 9U Sunflower 5G,2H 10P 10P Rape 7G 8G 9G Johnsongrass 80 9U IOU Sugar beets 90 10G 100 Bindweed 30 70 80 Table C (continued) Over-the-Top Soil/Foliage Treatment Compound 3 Rate kg/ha 0.016 0.064 0.25 Soybeans O 1G 70 Velvetleaf O -2G 40 Sesbania O 0 50 Cassia O 0 0 Cotton O 0 20 Morningglory O 0 30 Alfalfa O 0 30 Jimsonweed 0 20 70 Cocklebur O 3G 40 Corn 20 20 90 Crabgrass O 0 40 Rice 50 80 90 Nutsedge O 0 20 Barnyardgrass 20 30 60 Wheat O 3G 6G Giant foxtail O 5G Wild Oats 2G 4G 9G Sorghum 60 90 90 Sunflower 0 20 40 Rape O 10 50 Johnsongrass 0 60 9U Sugar beets O 2G 3G Bindweed O O 2G Table C (continued) Over-the-Top Soil/Foliage Treatment Compound 4 Rate kg/ha 0.004 0.016 0.064 0.25 Soybeans 80 90 90 100 Velvetleaf 40 40 80 90 Sesbania 3G 5G 9G 9G Cassia O O 4G 9G Cotton 40 40 60 90 Morningglory . 70 90 90 90 Alfalfa 60 60 70 90 Jimsonweed 60 60 90 90 Cocklebur 50 50 90 10P Corn 0 4G,3H 90 90 Crabgrass 0 80 90 100 Rice 60 80 90 90 Nutsedge 30 50 70 100 Barnyardgrass 80 100 100 100 Wheat 70 80 90 100 Giant foxtail 80 90 90 90 Wild Oats 80 90 90 90 Sorghum 80 8U 9U 9U Sunflower 20 4G,3H 90 100 Rape 60 80 90 90 Johnsongrass 80 9U lOU lOU Sugar beets 60 90 90 90 Bindweed 40 6G 80 80

Claims: Claims: BA-8454-A/59-A Cognate 1. A compound of the formula: EMI241.1 wherein R1 is H, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, SR4, OR5, CH20R6, CH2CH2OR6, N(CH3)2, CF3, CF2CF3, C1, NHCH3, N(CF3)2, CH(OCH3)2 or EMI241.2 R2 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2OCH3, CH2CH2OCH3, CH2SCH3, CH2CH2SCH3 or C1-C4 alkyl substituted with 1-3 F atoms; R3 is H or OH3; R4 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2C02R6 or CH(CH3)CO2R6; R5 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkenyl, CH2CO2R6, Ch(CH3)CO2R6 or CH2CF3; R6 is C1-C4 alkyl; W is O or S; ; Z is EMI241.3 EMI242.1 R7 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C(IO)NR21R22, Cl, Br, NO2, CF3, CO2R9, SO2NR10R11, C(O)SR10, SO2N(OCH3)CH3, QSO2R12, S(O)nR13, CH2CO2R20, CH(CH3)COR20, Ch2S(O)nR13, CH(CH3)S(O)nR13, C3-C4 alkenyloxy, C3-C4 alkenyloxy, C1-C2 alkyl substi tuted with either OCH3 or OC2H5, or C1-C3 alkoxy substituted with either a) 1-5 atoms of C1, Br or F or b) OCH3 or OC2H5; R8 is H, F, Cl, Br, CF3, NO2, C1-C3 alkyl or C1-C3 alkoxy; R9 is C1-C6 alkyl, CH2CH2OCH3, CH2CH2OCH2CH3, CH2CH2CH2OCH2CH3, C3-C6 alkenyl, C3-C6 alkynyl or C1-C alkyl substituted with 1-3 atoms of Cl or F; R10 and R11 are independently C1-C3 alkyl; R12 is C1-C4 alkyl, CH2CH20CH3, CH2CH2CH2OCH3 or C1-C4 alkyl substituted with 1-3 atoms of F, Cl or Br; ; R13 is C1-4 alkyl, allyl, C1-3 alkyl substituted with 1-5 atoms of F, Cl or Br; n is 0, 1 or 2; Q is O or NCH3; R14 is H, CH3, OCH3, F,Cl, Br, NO2, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12 or S(O)nR13; R15 is H, C1, Br, OH3, OCH3 or NO2; R16 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C1, Br, CF3, CO2R20, 502NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R17 is H, F, C1, Br, CH3 or OCH3; W' is O or S; R18 is H, C-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, NO2, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R19 is Cl, NO2, CF3, CO2R9, SO2N(OCH3)CH3, SO2NR10R11, QSO2R12, S(O)nR13 or C1-C3 alkoxy substituted with 1-5 atoms of Cl or F; R20 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; R21 is C1-C4 alkyl or C6H5; R22 is C1-C3 alkyl; and R21 and R22 may be taken together to be EMI243.1 provided that (1) the total number of carbbn atoms of R10 and R11 is less than or equal to 4; (2) the total number of carbon atoms of 9 and R2 is less than or equal to 6; (3) when W' is 0, then R18 is H, Cl, Br, CH3 or C02R20; (4) when W' is 0 and R18 is H, Cl, Br or CH3, then Z is EMI244.1 (5) when W is S, then R3 is H; (6) when R7 is H, then R8 is H; and (7) R14 and R15 may not both be NO2. 2. A compound of the formula: EMI244.2 wherein R' is H, CH3 or C2H5; R1' is CH3, C2H5, SCH3, OCH3, or OC2H5; R2' is CH3, C2H5 or OCH3; Z' is EMI244.3 R7 is C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, NO2, CF3, CO2R9, SO2NR10R11, C(O)NR21R22, SO2N(OCH3)CH3, QSO2R12, S(O)nR13, C(O)SR10, CH2CO2R20, CH(CH3)CO2R20, CH2S(O)nR13, CH(CH3)S(O)nR13, C3-C4 alkenyloxy, C3-C4 alkynyloxy, C1-C2 alkyl substi tuted with either OCH3 or OC2H5, or C1-C3 alkoxy substituted with either a) 1-5 atoms of Cl, Br or F or b) OCH3 or C2H5; R8 is H, F, C1, Br, CF3, NO2, C1-C3 alkyl or C1-C3 alkoxy; R9 is C1-C6 alkyl, CH2CH2OCH3, CH2CH2OCH2CH3, CH2CH2CH2OCH2CH3, C3-C6 alkenyl, C3-C6 alkynyl or C1-C3 alkyl substituted with 1-3 atoms of Cl or F; R10 and R11 are independently C1-C3 alkyl; ; Rl2 is C1-C4 alkyl, CH2CH20CH3, CH2CH2CH2OCH3 or C1-C4 alkyl substituted with 1-3 atoms of F, Cl or Br; R13 is C1-C4 alkyl or allyl; R14 is H, CH3, OCH3, F, C1, Br, NO2, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12 or S(O)nR13; Rl6 is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, CF3, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R18 is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, NO2, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R20 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; Q is O or NCH3; n is o, 1 or 2; R21 is C1-C3 alkyl or C6H5; R22 is C1-C3 alkyl; and R21 and R22 may be taken together to be EMI245.1 provided that (1) the total number of carbon atoms of R10 and R11 is less than or equal to 4; and (2) R1, and R2, can not simultaneously be H; and their agriculturally suitable salts. 3. Compounds of Claim 1 wherein W is 0 and R3 is H. 4. Compounds of Claim 3 where Z is EMI246.1 W' is S; 19 is C02CH3, SO2N(CH3)2 or S 2CH3; and R15 and R17 are H. 5. Compounds of Claim 4 where Z is EMI246.2 6. Compounds of Claim 5 where R1 is C1-C2 alkyl, SR4, OR5, CH20CH3, N(CH3)2 or Cl; R2 is C1-C2 alkyl, CH2CF3, CH2CH=CH2 or CH2C=CH; and R4 and R5 are independently CH3 or C2H5. 7. Compounds of Claim 6 where Z is EMI247.1 R7 is other than H; and R8 is H, F, C1, Br, CF3, CH3 or OCH3. 8. Compounds of Claim 7 where R7 is Cl, NO2, CO2R9, SO2NR10R11 or OSO2R12; R8 is H; R9 is C1-C3 alkyl, CH2CH=CH2, CH2CH2OCH3 or CH2CH2Cl; R10 and R11 are independently C1-C2 alkyl; and Rl2 and R13 are independently C1-C3 alkyl. -9. Compounds of Claim 8 where R9, R10, R11, R12 and Rl3 are CH3. 10. Compounds of Claim 2 where R' is CH3 or C2H5. 11. Compounds of Claim 13 where Z' is EMI247.2 and R8 is H, F, Cl, Br, CF3, CH3 or OCH3. 12. Compounds of Claim 11 where R7 is Cl, NO2, CO2R9, SO2NR10R11, O502R12 or S02R13; R8 is H; Rg is C1-C3 alkyl, CH2CH2=CH2, CH2CH20CH3 or CH2CH2C1; R10 and R11 are independently C1-C2 alkyl; and R12 and R13 are independently C1-C3 alkyl. 13. Compounds of Claim 12 where Rg, R10, R11,R12 and R13 are CH3. 14. The compound of Claim 1 which is 2-[[(5 methylthio-l-methyl-lH-1,2,4-triazol-5-yl)aminocar- bonyl]aminosulfonyl]benzoic acid, methyl ester. 15. The compound of Claim 1 which is 2-tt(5- ethylthio-1-methyl-1H-1,2,4-triazol-3-yl)aminocarbonyllaminosulfonyl]benzoic acid, methyl ester. 16. The compound of Claim 1 which is 2-tt(5- ethyl-1-methyl-1H-1,2,4-triazol-3-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester. 17. The compound of Claim 1 which is 2-t[(5- methoxy-l-methyl-lH-1,2,4-triazol-3-yl)aminocarbonyl] aminosulfonyl]benzoic acid, methyl ester. 18. The compound of Claim 1 which is N-[(5 methOxy-l-methyl-lH-1,2,4-triazol-3-yl)aminocarbonyl]- 2-chlorobenzenesulfonamide. 19. The compound of Claim 1 which is N-[(5methoxy-l-methyl-lH-1,2,4-triazol-3-yl)amlnocarbonyl] N',N'-dimethyl-1,2-benzenedisulfonamide. 20. The compound of Claim 2 which is 2-[[(4,5- dimethyl-lH-imidazol-2-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester. 21. A compound of claim 1 wherein R1 is H, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, SR4, OR5, CH2OR6, CH2CH2OR6, N(CH3)2, CF3 or CF2CF3; R2 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2OCH3, CH2CH2OCH3, CH2SCH3 or CH2CH 2SCH3; R5 is C1-C4 alkyl, C3-C4 alkenyl or C3-C4 alkynyl; W is O or S; EMI249.1 R7 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C1, Br, NO2, CF3,C02Rg, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12, S(O)nR13, OCF3, OCHF2 OCF2CF2H or CH20R13; R9 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; R13 is C 1-C4 alkyl; n is O or 2; and R3, R4, R6, R8, R10, R11, R12, R14, R15, R16, R17, R18, W and W' are as defined in claim 1. 22. A compound of claim 2 wherein R' is CH3 or C2H5; R7 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C1, Br, NO2, CF3, CO2R9, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12, S(O)nR13, OCF3, OCHF2, OCF2CF2H or CH20R13; Rg is C1-C4 alkyl, CH2CH2OCH3, CH2CH2C1 or CH2CH=CH2; R13 is C1-C4 alkyl; n is O or 2; R14 is H, CH3, OCH3, F, C1, Br, NO2, S02NR10R11, S 2R12 or S(O) nR13; and RL, R1 , ZV, R8 Rlo, h! R12, R16 and R18 are as defined in claim 2. 23. A composition suitable for controlling the growth of undesired vegetation comprising an effective amount of a herbicidal compound and at least one of the following: surfactant, solid or liquid diluent, characterised in that said herbicidal compound comprises a compound of any of claims 1 to 22. 24. A method for controlling the growth of undesired vegetation by applying to the locus to be protected an effective amount of a herbicidal compound, characterised in that said herbicidal compound comprises a compound of any of claims 1 to 22. 25. A process for making a compound of claim 1 which comprises (a) reacting together compounds of formulae EMI250.1 and ZSO2NCW wherein R1, R2, R3, W and Z are as defined in claim 1; or (b) alkylating a compound of formula EMI251.1 wherein R1, R3 and Z are as defined in claim 1, with a reagent of formula R2X wherein R2 is as defined in claim 1 and X is a leaving group. 26. A process for making a compound of claim 2 which comprises reacting together compounds of formulae Z'SO2NCO and EMI251.2 wherein R' R', R'2, and Z' are as defined in claim 2. Claims: 1. A process for the production of a compound of the formula: EMI252.1 wherein R1 is H, C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, SR4, OR5, CH20R6, CH2CH2OR6, N(CH3)2, CF3, CF2CF3, Cl, NHCH3, N(CH3)2, CH(OCH3)2 or EMI252.2 R2 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2OCH3, CH2CH2OCH3, CH2SCH3, CH2CH2SCH3 or C1-C4 alkyl substituted with 1-3 F atoms; R3 is H or CH3; R4 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2C02R6 or CH(CH3)C02R6i R5 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2CO2R6, CH(CH3)CO2R6 or CH2CF3; R6 is C1-C4 alkyl; W is O or S; ; Z is EMI252.3 EMI253.1 R7 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C(O)NR21R22, Cl, Br, NO2, CF3, CO2R9, SO2NR10R11, C(O)SR10, SO2N(OCH3)CH3, QSO2R12, S(O)nR13, CH2CO2R20, CH(CH3)CO2R20, CH2S(O)nR13, CH(CH3)S(O)nR13, C3-C4 alkenyloxy, C3-C4 alkynyloxy, C1-C2 alkyl substi tuted with either OCH3 or OC2H5, or C1-C3 alkoxy substituted with either a) 1-5 atoms of C1, Br or F or b) OCH3 or OC2H5; R8 is H, F, C1, Br, CF3, NO2, C1-C3 alkyl or C1-C3 alkoxy; R9 is C1-C6 alkyl, CH2CH2OCH3, CH2CH2OCH2CH3, CH2CH2CH2OCH2CH3, C3-C6 alkenyl, C3-C6 alkynyl or C1-C3 alkyl substituted with 1-3 atoms of Cl or F; R10 and R11 are independently C1-C3 alkyl; R12 is C1-C4 alkyl, CH2CH20CH3, CH2CH2CH2OCH3 or C1-C4 alkyl substituted with 1-3 atoms of F, Cl or Br; ; R13 is C1-C4 alkyl, allyl, C1-C3 alkyl substituted with 1-5 atoms of F, Cl or Br; n is 0, 1 or 2; Q is O or NCH3; R14 is H, OK3, OCH3, F, C1, Br, N02, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12 or S(O)nR13; R15 is H, C1, Br, OH3, OCH3 or NO2; R16 is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, CF3, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R17 is H, F, C1, Br, CH3 or OCH3; W' is O or S; R18 is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, NO2, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R19 is C1, NO2, CF3, C02RgS 502N(OCH3)CH3, SO2NR10R11, QSO2 R12, S(O)nR13 or C1-C3 alkoxy substituted with 1-5 atoms of Cl or F; ; R20 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; R21 is C1-C3 alkyl or R22 is C1-C3 alkyl; and R21 and R22 may be taken together to be EMI254.1 provided that (1) the total number of carbon atoms of R10 and R11 is less than or equal to 4; (2) the total number of carbon atoms of R and R2 is less than or equal to 6; (3) when W' is 0; then R18 is H, C1, Br, CH3 or C02R20; (4) when W' is 0 and R18 is H, Cl, Br or CH3, then Z is EMI255.1 (5) when W is S, then R3 is H; (6) when R7 is H, then R8 is H; and (7) Rl4 and R15 may. not both be NO2, which comprises (a) reacting together compounds of formulae EMI255.2 and ZS02NCW wherein R1, R2, R3, W and Z are as defined above; or (b) aikylating a compound of formula EMI255.3 wherein R1, R3 and Z are as defined above with a reagent of formula R2X wherein R2 is as defined above and X is a leaving group. 2. A process for the production of a compound of the formula: EMI255.4 wherein R is H, CH3 or C2H5; R1' is CH3, C2H5, SCH3, OCH3 or OC2Hg; R2' is CH3, C2H5 or OCH3; Z' is EMI256.1 R7 is C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, NO2, CF3, CO2R9, SO2NR10R11, C(O)NR21R22, SO2N(OCH3)CH3, QSO2R12, S(O)nR13, C(O)SR10, CH2CO2R20, CH(CH3)CO2R20, CH2S(O)nR13, CH(CH3)S(O)nR13, C3-C4 alkenyloxy, C3-C4 alkynyloxy, C1-C2 alkyl substi tuted with either OCH3 or OC2H5, or C1-C3 alkoxy substituted with either a) 1-5 atoms of C1, Br or F or b) OCH3 or OC2H5; R8 is H, F, C1, Br, CF3, NO2, C1-C3 alkyl or C1-C3 alkoxy; ; R9 is C1-C6 alkyl, CH2CH2OCH3, CH2CH2OCH2CH3, CH2CH2CH2OCH2CH3, C3-C6alkenyl, C3-C6 alkynyl or C1-C3 alkyl substituted with 1-3 atoms of Cl or F; R10 and R11 are independently C1-C3 alkyl; R12 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2CH2OCH3 or C1-C4 alkyl substituted with 1-3 atoms of F, Cl or Br; R13 is C1-C4 alkyl or allyl; R14 is H, CH3, OCH3, F, C1, Br, NO2, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12 or S(O)nR13; R16 is H, C1-C4 alkyl, C1-C4 alkoxy, F, Cl, Br, CF3, CO2R20, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R18 is H, C1-C4 alkyl, C1-C4 alkoxy, F, C1, Br, NO2, C02R2o, SO2NR10R11, SO2N(OCH3)CH3 or S(O)nR13; R20 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; Q is O or NCH3; n is 0, 1 or 2; R21 is C1-C3 alkyl or C6H5; R22 is C1-C3 alkyl; and and and R22 may be taken together to be EMI257.1 provided that (1) the total number of carbon atoms of R10 and R11 is less than or equal to 4; and (2) R1' and R2' can not simultaneously be H; and their agriculturally suitable salts; which comprises reacting together compounds of formulae Z'SO2NCO and EMI257.2 wherein R', R', R'2, and Z' are as defined above. 3. A. process of claim 1 wherein R1 is H, C1-C4 alkyl, C3-C4 alkenyl, C 3-C4 alkynyl, SR4, OR5, CH20R6, CH2CH2OR6, N(CH3)2, CF3 or CF2CF3; R2 is C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, CH2OCH3, CH2CH2OCH3, CH2SCH3 or CH2CH2SCH3; R5 is C1-C4 alkyl, C3-C4 alkenyl or C3-C4 alkynyl; W is O or S; EMI258.1 R7 is H, C1-C4 alkyl, C1-C4 alkoxy, F, 4 C1, Br, NO2, CF3, CO2R9, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12, S(O)nR13, OCF3, OCHF2 OCF2CF2H or CH2OR13; R9 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; R13 is C -C4 alkyl; n is O or 2; ; and R3, R4, R6, R8, R10, R11, R12, R14, R15, R16, R17, R18, W and W' are as defined in claim 1. 4. A process of claim 1 or 3 wherein W is 0 and R3 is H. 5. A process of claim 4 where Z is EMI259.1 W' is S; Rl9 is CO2CH3, S02N(CH3)2 or SO2CH3; and R15 and R17 are H. 6. A process of Claim 5 where Z is EMI259.2 7. A process of Claim 6 where R1 is C1-C2 alkyl1 SR4, OR5, CH20CH3, N(CH3)2 or C1; R2 is C1-C2 alkyl, CH2CF3, CH2CH=CH2 or CH2C=CH; and R4 and R5 are independently CH3 or c2H5. 8. A process of Claim 7 where Z is EMI260.1 R7 is other than H; and R8 is H, F, C1, Br, CF3, CH3 or OCH3. 9. A process of Claim 8 where R7 is Cl, NO2, CO2R9, SO2NR10R11 or OSO2R12; R8 is H; Rg is C1-C3 alkyl, CH2CH=CH2, CH2CH2OCH3 or CH2CH2Cl; R10 and R11 are independently C1-C2 alkyl; and R12 and R13 are independently C1-C3 alkyl. 10. A process of Claim 9 where R9, R101 R11, R12 and R13 are CH3. 11. A process of claim 1 or 3 wherein the product is a compound selected from 2-[[(s- methylthio-l-methyl-lH-1,2,4-triazol-3-yl)aminocar- bonyl]aminosulfonyl)benzoic acid, methyl ester; 2-t[(5- ethylthio-1-methyl-1H-1,2,4-triazol-3-yl)aminocarbonyl]aminosulfonyl]bezoic acid, methyl ester; 2-[[(5 ethyl-l-methyl-lH-1,2,4-triazol-3-yl)aminocarbonylJ- aminosulfonyl]benzoic acid, methyl ester; 2-[[(5- methoxy-1-methyl-1H-1,2,4-triazol-3-yl)aminocarbonyl]aminosulfonyl]benzoic acid, methyl ester; N-[(5methoxy-1-methyl-1H-1,2,4-triazol-3-yl)aminocarbonyl]2-chlorobenzenesulfonamide; and N-[(5 methoxy-l-methyl-lH-1,2,-triazol-3-yllamimocarbonyl]- N',N'-dimethyl-1,2-benzenedisulfonamide. 12. A process of claim 2 wherein R2' is CH3 or C2H5; R7 is H, C1-C4 alkyl, C 1-C4 alkoxy, F, Cl, Br, NO2, CF3, CO2R9, SO2NR10R11, SO2N(OCH3)CH3, OSO2R12, S(O)nR13, OCF3, OCHF2, OCF2CF2H or CH20R13; R9 is C1-C4 alkyl, CH2CH2OCH3, CH2CH2Cl or CH2CH=CH2; R13 is C1-C4 alkyl; n is O or 2; R14 is H, CH3, OCH3, F, C1, Br, N02, SO2NR10R11, OSO2R12 or S(O)nR13; and R', R1', Z', R8, R10, R11, R12, R16 and R18are as defined in claim 2. .13. A process of Claim 2 or 12 where R' is CH3 or C 2H5. 14. A process of Claim 13 where Z' is EMI261.1 and R8 is H, F, Cl, Br, CF3, CH3 or OCH3. 15. A process of Claim 14 where R7 is Cl, NO2, CO2R9, SO2NR10R11, oS02R12 or 502R13; R8 is H; R9 is C1-C3 alkyl, CH2CH2=CH2, CH2CH20CH3 or CH2CH2C1; R10 and R11 are independently C1-C2 alkyl; and R12 and R13 are independently C1-C3 alkyl. 16. A process of. Claim 12 where Rg, R10, R11, R12 and R13 are CH3. 17. A process of claim 2 or 12 wherein the product is 2-[[(4,5-dimethyl-1H-imidazol-2-yl)aminocarbonyl] aminosulfonyl]-benzoic acid, methyl ester. 18. A method for controlling the growth of undesired vegetation by applying to the locus to be protected an effective amount of a herbicidal compound, characterised in that said herbicidal compound comprises a compound of formula (I) as defined in any of claims I or 3Oil. 19. A method for controlling the growth of undesired vegetation by applying to the locus to be protected an effective amount of a herbicidal compound, characterised in that said herbicidal compound comprises a compound of formula (Ia) as defined in any of claims 2 or 12-17.

Inventors: FITZGERALD, DAVID JOSEPH, SELBY, THOMAS PAUL, WOLF, ANTHONY DAVID
Applicants: E.I. DU PONT DE NEMOURS AND COMPANY
Application year: 1982
Main classification: C07D249
IPC codes: C07D521, A01N47, C07D249, C07D233