NOVEL COSMETIC COMPOSITIONS CONTAINING PRENYLAMINE AND A PROCESS FOR THEIR PREPARATION

Abstract: Novel cosmetic compositions containing 3,3-diphenyl-propyl-1-methyl-phenetylamine (prenylamine) or an acid addition salt thereof and a process for their preparation. More closely, the invention relates to cosmetic products containing 3,3-diphenyl-propyl-1-methyl-phenetylamine or an acid addition salt thereof, especially to tooth-pastes, dentrifices, deodorants, creams, shaving-creams, soaps, foam baths or shampoos. The novel compositions of the invention can be used advantageously for the body hygiene or persons with oily and sensitive skin which tends to allergy, furthermore for the prevention of some malfunctions of the mouth.

Description: NOVEL COSMETIC COMPOSITIONS CONTAINING PRENYLAMINE AND A PROCESS FOR THEIR PREPARATION TECHNICAL FIELD The invention relates to novel cos¬ metic compositions containing 3 } 3- d -iP nen yl-P :ro Pyl- -1-πιethyl-phenetylamine (prenylamine) and a process for their preparation* More closely the invention relates to cosmetic products containing j3-ii- phenyl-propyl-1-methyl-phenetyl-aπiine or an acid addition salt thereof, especially to tooth-pastes, dentifrices, deodorants, creams, shaving-creams, soaps, foam baths or shampoos* The novel composi- tions of the invention can be used advantageously for the body hygiene of persons with oily and sen¬ sitive skin which tends to allergy, furthermore for the prevention of some malfunctions of the mouth- BACKGROUND ART The cosmetics serve according to the traditional valuation the beautifying and embel- lishment of the skin' and improve the aesthetic and pleasent properties of the same. According to a more modern opinion the cosmetics are con¬ sidered as being materials which contact differ¬ ent parts of the body (skin surface, hair, nails, lips, teeth, genitals and mycoderms) first of all in order to scent, protect or keep them in good state, to change their exterior or to deodorize the body odour. It becomes harder and harder to please the buyers of cosmetics and the expectations con¬ cerning cosmetic products become higher and higher. Today more and more cosmetic products possessing prophylactic effect are produced and marketed * Such products are e,g, the tooth-pastes contain¬ ing fluoro compounds which inhibit cariesj the deodorants containing bacteriostatica which pre¬ vent germ formationj creams containing bioactive materials and vitamins as well as cosmetics free of allergens • The preparation of such products repre¬ sents a serious problem in the cosmetic industry, The ensuring of the microbiological purity leads to serious difficulties during the preparation of modern products of great effect. The cosmetic industry carries on a persistent fight, on the one hand, in order to provide the consumer with products which have the lowest possible germ number and which are good stabilized, on the other hand, with the health authorities like drug administrations in order to increase the sphere of applicability of the few antibacterial materials which can be used against common bacterium strains becoming more and more resistant and which are bound to a per¬ mission. In the practice materials possessing antibacterial effect are used for conserving and stabilizing cosmetics, especially creams. Such material is e,g, the me hylparaben (p_-hydroxy- benzoic acidmethylester) or the propylparaben (p_-hydroxybenzoic acidpropylester), Recently the cosmetic specialists stated worried that the variety of applicable antibacterial materials is not sufficient* Their frequent use was accompanied by the formation of resistant bacterium strains. The increase of the quantity of antibacterial materials permitted up to now for cosmetic purposes cause in some cases such negative derma'tological symptoms which sur¬ passed the original effect of the cosmetics. In other cases embryotoxic properties appeared when using e,g* hexachlorophene (3, 3 ' , ^, -*' ,6,6'-hexa- chloro- ,2' -methylenediphenol), The preparation of cosmetic products with a minimal number of germs is thus a signifi¬ cant problem which could not be solved sufficient¬ ly up to now. The microbiological purity of a cosmetic product is especially important in the case of products which can contact with chroni- cally or latently sickened parts of the user 1 s body in the course of the application* The most dangerous areas are the following: the cavity of mouth, the eye and its surrounding, the genitals, the armpits, the parts between the toes and the complete body surface of a baby. According to practical experiences the presently used conserving materials cannot be con¬ sidered sufficient in the least. In many cases it can be presumed that a cosmetic product not suf¬ ficiently free of germ is responsible for the appearance of some acute in lammations or allergic coπ laints on the mouth mycodor or eye conjunc¬ tiva. - k Principally the producers of cosmetics produce the products for healthy people* In a part of the cases, however, the consumer looks for a cosmetic products healing a type of diseases belonging to the sphere of dermatology. In such case the product not sufficiently free of germ and even of a prophylactum does more harm to the already sick and sensitive skin than good, A pure cosmetic product itself can also cause a skin disease. In most of the cases a skin inflammation occurs at the place of use. The formation of contact dermatitis is really the main problem. The malfunction emerges on the place of use with prurigo, then with turning red, oedematic swelling, finally with blebs * Pigmentation dis¬ order of the skin can also occur which is presum¬ ably the consequence of the use of the cosmetic products. Later these malfunctions can spread all over the whole surface of the body. The formation of contact dermatitis is generally characteristic for people with sensitive skin * This state can be called actually as al- lergy. The allergen material causing exaggerated sensitivity may be contained in the odouring com¬ ponent of the cosmetic product: it can be the sur¬ face-active substancej the disinfectant itself; the colouring agentj the basic material of poor quality; lanolinj maybe the toxin of the bacter- iums impurifying the cosmetic product, too, and so on. In such cases the conjunctivitis of the eye, the inflamination of the mycodorm of the mouth and the genitals, the inflammation of the lips or on the effect of light a pigment disorder in the skin can emerge rapidly in the presence of the cosmetic product as secondary processes, Nowadays the consumer expects already to be in the position to buy a cosmetic product suitable for types of diseases which seem to be a cosmetic defect, but which actually can be considered as a chronical dermatological case, too. Such types of diseases are the following: the oily and dry seborreaj the juvenile pimples; comedosj elderly rosacea; the exaggerated dryness or oilincss of the skin of face; the exaggerated perspiring; the hypertrichosis; in certain re— spects diseases of the hair and the nails; the fungoid growth and last butnot least the psoriasis; in gynaecological respect the discharge and the prurigo. The consumer expects also from the tooth¬ pastes and oral hygiene products a caries pre- venting. effect. All these circumstances are ren¬ dered more difficult by the fact that at the present there are no specifically and safely applicable medicaments against the elucidated, types of diseases. The above problems are the main prob¬ lems of the cosmetic industry at present because there is no material which itself would satisfy these complex cosmetic demands. It is known that prenylamine lactate and prenylamine fumarate are excellently suitable for the oral treatment of gastroentorological diseases, thus for the so-called dumping syndrome, OMP zymotic dyspepsia, chronical diarrhoea, lactose- —intolerances, food-intolerances and of skin changes inherent in dispesy [Szatlόczky and Irsay: Medicus Universalis, 2_, 17-19 (1969); Szatlόczky and Barthy: Dtsch,med.Wschr. , £7., 1125 (1972); Szatlόczky, Racz, Csakvary, Zalay and Teraesvary; VTIIth Itinerary Congress of the Hungarian Allergo- logic and Clinical Imraunological Society, Budapest, April 19-21, 1978, Syllabus of Lectures, page -6 21st General Meeting of the Hungarian Gynaecolo¬ gist Society, ' Debrecen, November 8-11, 1981, Sum¬ maries, page 281* Moreover, they possess a slight β-symphatholytic effect * Clinical experiences showed that the prenylamine inhibits the absorption in the gastric and intestinal tract, furthermore that it exerts a. bacteriostatic and bactericidal effect, respec¬ tively* DISCLOSURE OF THE INVENTION It was found surprisingly that cosmetic products containing prenylamine or an acid addition salts thereof are excellently suitable for the reduction and normalization of the exaggerated sensivity, further or the disin ection of human skin and the mycodorms, for the deodorizing of the sweat glands, for the inhibition of the prurigo of the skin, for the enhancement of the hair growth and the prevention of certain cases of greying. The cosmetic compositions according to the invention contain 3 > 3-<iiphenylpropyl-l-methyl- -phenetylamine (prenylamine) or an acid addition salt thereof together with auxiliary materials usual in the production of cosmetic compositions* The compositions of the invention con¬ tain preferably lactate or fumarate as the. acid addition salt of prenylamine* The cosmetic composition of the inven¬ tion can be e,g, tooth-paste, tooth-wash, mouth deodorant spray, cream, , shaving-cream, soap, foam bath or shampoo and generally contains 0,05 to 8,0 percent by weight of prenylamine or an acid addi¬ tion salt, 20 to 99 percent by weight of solvent(s), 0 to 70 percent by weight of wash-active substance(s) and/or emulsifying agent(s), 0 to 20 percent by weight of cosmetic additive(a.) and 0 to 35 percent by weight of a filler, and optionally, if the prod¬ uct is filled into an aerosol flask, a propellant is present, too, where the weight ratio of" the product to be sprayed to the propellant is from 1:1 to 20:1, One advantageous group of the composi¬ tions of the invention are the mouth hygiene prod¬ ucts, e,g, the tooth-paste, tooth-jelly, tooth- wash or tooth-spray * Especially advantageous is tooth-paste which contains 0,05-8*0 percent by weight, mo-re preferably 0*5-2*0 percent by weight of prenylamine or an acid addition salt thereof together the usual components of tooth-paste. Another advantageous group of the cos- metic compositions of the invention are the deodor- ants which generally contain 0,05-8 * 0 percent by weight, advantageously 0,5-2 * 0 percent by weight • 5 of prenylamine or an acid addition salt thereof together with the usual components of deodorants* The deodorants of the invention can be aerosol deodorants, solutions or deodorants used in the form of a stick (roller) * 10 In the cosmetic compositions of the in¬ vention the solvent is advantageously water; a lower aliphatic alcohol, e*g* ethanol; a higher aliphatic alcohol, e,g, cetylalcohol, octyldo- 15 decanol or oleilalcohol; fatty acid, e * g, stearic acid, or an alkali metal salt of a fatty acid; a , . saturated or unsaturated fatty acid ester, e.g. propyl myristate or a fatty alcohol ester of oleic acid; a polyhydroxy alcohol, e,g, glycerine; a 0 polyglycolether; a mono-, di- or triester of glycerine formed with a fatty acid; or paraffine- oil. The compositions of the invention can con¬ tain more than one solvent at the same time, 5 . The wash-active material (or surface- -active material) can be a material generally used for this purpose in cosmetic products, e,g* sodium lauryl sulfato, sodium laurylether sulfate or fatty alcoholether sulfate. These materials 0 are " used e,g, in shampoos. As emulsifying agent e,g, polyoxyethylono sorbitano monostoarate can be used* An emulsifying agent or a mixture of emulsifying agents is used first of all in creams and lotions, The cosmetic additive is that usually used in cosmetic products, e.g, odouring agent, flavouring agent, sweetener, suitably 3-oxo-2,3- -dihydro-1, -benzisothiazole-l,1-dioxide, sorbite or xylitol; colouring agent; pigment, e,g* tita¬ nium dioxide; fluoro compound, e,g, sodium fluor¬ ide or sodium mono luorophosphate; cocoanut fatty acid diethanolamide; potassium carbonate; lanolin; silicone oil; bioactive material, e,g, cholesterol and vitamins, and so on. The filling agent can be c,g, dicalcium phosphate, dispersed silicic acid and so on, A filling agent is necessary first of all for the production of tooth-paste. If the cosmetic composition of the in¬ vention is to be used as aerosol it is filled into aerosol flasks together with a propellant generally used for preparing aerosol products. The prenylamine and the acid addition salts thereof are slightly water-soluble compounds, thus they themselves are hardly absorbed directly through the surface of the skin, Therefore it is surprising for a person skilled in tne art that solvents like e,g, glycerol , cctyl alcohol, poly- ethyleneglycol, polypropyleneglycol, isopropyl myristate or glycerol monostearate otherwise promoting the hydration of the skin ensure the absorption of prenylamine and the salts thereof into the outer layers of the skin. The trans- fullicular absorption is a bit slower, but still sufficient in the case of using emulsions formed with emulsifying agents* Especially rapid is the absorption if a prenylamine or the salts thereof are applied onto the skin surface in the form of an aerosol. Therefore the particularly advantage- ous form of the composition of the invention is the cosmetic product form being convertible into an aerosol* The prenylamine or the acid addition salts tnereof being present in the cosmetic com¬ positions of the invention in dissolved form en¬ sure the preservation of the composition itself, thus the use of chemical conserving agents, which by the way only increase the sensivity of the skin, is mostly not necessary. The compositions of the invention contain optionally bioactive materials generally used in cosmetic products, too, with which the prenylamine or a salt thereof optionally shows synergism * The novel cosmetic compositions or the invention can be in the form of e*g* tooth-pastes, dentifrices, deodorants, intimate deodorants, creams, protective creams, shampoos, foam baths, antitrajispirants, light protecting products, lo¬ tions, milks, body lotions, soaps, hair-lotions, oot-lotions, shaving-creams and cosmetic products or babies and children* Their presentation can be the one gen¬ erally used in the case of cosmetic products, thus they can be filled or packed into e,g, a tube, jar. flask, plastic box, plastic foil and so on, A specially advantageous product form is the solu¬ tion formable to an aerosol in the case of which the spraying is ensured by propellan s known per se. The cosmetic composition of the inven¬ tion is prepared by mixing the components with each other. Generally one proceeds so that 0,05 to 8,0 percent by weight of prenylamine or an acid addition salt thereof are dissolved in a solvent or a solvent mixture; if desired, the mixture is admixed to further solvent(s) up to a solvent quantity of altogether 20-99 percent by weight; the thus-obtained solution is admixed to altogether 0 to 70 percent by weight of wash-active material(s) and/or emulsifying agent(s), 0 to 20 percent by weight of cosmetic additive agent(s) and 0 to 35 percent by weight of fxlling agent(s). The obtained composition is filled into package units generally used for cosmetic products. In the case of a spray the weight ratio between the products to be sprayed and the propellant is adjusted to a value of from 1:1 to 20:1. The use of the cosmetic compositions of the invention is advantageous mainly for such Indi¬ viduals whose skin is specially sensitive or oily and who are susceptible to allergic diseases ' or possibly suffer from allergic diseases. The compo¬ sitions of the invention disinfect tne skin and the mycoderms well, respectively, reduce the prurigo of the skin, i.e, they exert a good skin sedative effect. They are advantageous in cases of chronic or acute irritation of the mycoderms. They are suitable to reduce the prurigo occuring on in¬ dividuals with sensitive skin after using foam baths, sun-creams, shampoos, etc* containing sur- face-active substances. Using the hair preparation of the invention the pityriasis of the scalp can be prevented as well as a speeding up of the hair growth and the pigment can be attained. The deodor¬ ant of the invention exerts a deodorizing effect on the secretions of the glands weeping sweat and normalizes the operation of these glands. Although the exact mechanism of the action of the novel cosmetic compositions of the invention is not known it seems to be probable that among others they restrict the release of the histamine and the histamine-like substances in the skin and influence the symptoms caused by the PGF -overproduction. The prenylamine existing in the cos¬ metic compositions of the invention inhibits the growth of Gram negative and Gram positive bac¬ teria, yeasts and fungi. In comparison witiα other preservative agents extensively used in cosmetic products its effect is very advantageous, its toxicity is low and it is active in a wide pH range (between k and 9)» In. Table I the minimal inhibiting concentration value (MIC) of some known preservative agents and the optimal pH range thereof are indicated. Table I Characteristics of the known cosmetic preservative agents Preservative Minimal inhibiting concentration yug/ml Optimal agent Gram posi- Gram nega- Yeast Fungus pH- tive tive range m i c r o o r g a n i s m 10 Hexachlorophene X 1-10 - - - 4-9 H Methylparabene XX 800 1000 1000 500 -7 3 Benzylparabene 50 200 100 75 4-7 15 3 ) 3' > 4,4' , 6, 6' -hexachloro-2,2' -methylene-diphenol (possessing embryotoxic effect) xxp-hydroxybenzoic acid methylester XXXp-hydroxybenzoic acid benzylester o ' Table H contains the minimal inhibit¬ ing concentrations of prenylamine against some important microorganism strains. Table II The effect of prenylamine oh microorganism Microorganism MIC Type of the 1 •ug/ml action Staphylococcus aureus 30 bactericidal Staphylococcus epidermis 30 bactericidal Streptococcus hacmolyticus 5 bactericidal Streptococcus mitis 5 bactericidal Streptococcus pneumoniae 30 bactericidal Streptococcus mutatis 5 bactericidal Lactobacillus acidophylus 5 bactericidal Corynebacterium dihpteriae 10 bactericidal Listeria monocytogenes 10 bactericidal Haemophilus influensae 60 bactericidal Neisseria pharingis 20 bactericidal Candida albicans 100 fungicidal In cosmetic compositions of the inven¬ tion containing 0,05 to 0,25 percent by weight of prenylamine a bacteriostatic effect already ap¬ pears, A bactericidal effect can be observed in the case of compositions products containing 0.25 to 0,90 percent by weight of prenylamine, too. By using compositions containing 0.05 to 8,0 percent by weight of prenylamine special cosme¬ tic effects, e,g, deodorization, inhibition of the prurigo, ceasing of gums bleeding and gingi¬ vitis, the ' reduction of caries, etc,, can be at¬ tained, The effect of oral hygiene ' products forming a special advantageous subgroup of the composition according to the invention on gingi¬ vitis was examined in detail. The most sensitive range of the antimicrobial spectrum of prenyl- amine covers a significant part of the normal microbial flora of the mouth cavity. Accordingly it is expected that the oral hygiene products of the invention containing prenylamine (tooth¬ paste, tooth-wash, mouth spray, tooth-jelly) when constantly used lead to a decrease of the germs in the mouth. This is in itself a big result, but surprisingly it was found that with the constant use of the oral hygiene prodticts of the invention some diseases of the mouth, e.g. gums bleeding, gingivitis, caries and tooth loosening, can be avoided. The tooth-paste having a composition according to Example 10, containing 0,9 percent by weight of prenylamine lactate was examined in the case of a test a group consisting of 2.6 women and 7 men with an average age of 37 years. The mem¬ bers of the group cleaned their teeth twice a day for 5 weeks with the tooth-paste to be tested. The members of the control group con¬ sisting of 12 women and 7 men with an average age of 34 years used tooth-paste with the same compo¬ sition but without prenylamine lactate twice a day for 5 weeks. In the test group, the gums bleeding representing the first state of gingivitis was observed at 8 persons, in the control group at 6 persons. On the effect of the treatment in the test group in the case of 3 persons the gums bleeding ceased after 8 days, after further 6 days at 4 persons. In the case of the last one person the bleeding ceased only after a 4 week treatment. In the control group there was no change, at the end of the 5 week period the same 6 persons suffered from gums bleeding, Thus the treatment with the tooth-paste of the invention ceased the gums bleeding, pre¬ sumably due to the fact that the tooth-paste neu¬ tralizes the effect of tne dentogingival plaque causing gums bleeding and caries although the quantity of the plaque itself is reduced only to a small degree. In the course of the above examinations it was observed futhermore that the test product did not harm the mouth mycoderm, the ratio of the hypercornificated and superfisial cells ensuring the normal dcfoήsion ability of the epidermis even increased* Accordingly the consequence can be drawn that when using constantly the oral hygiene products of the invention the gingivitis can be avoided, its first initial state, the gums bleed¬ ing, can be cured, and the formation of caries considered as widespread disease in numerous coun¬ tries of the world can be avoided or at least re¬ tarded significantly. At the same time the tooth¬ paste of the invention does not discolour the dental prothesises, MODES FOR CARRYING OUT THE INVENTION The invention is illustrated by the aid of the following non-limiting examples* Example 1 . Aerosol deodorant Composition: Isopropyl myristate 1, , 8 s Ethanol 96- , 0 s Prenylamine lactate 1. , 0 s Odour 1. , 2 s 100. 0 s , Propellant: Freon F 12, The weight ratio or the charge and the propellant is 2:1 * In the above quantity of ethanol the components are dissolved, the solution is filtered, then it is filled into an aerosol flask, Besides the general cosmetic effect the product ensures deodorizing and disin ection, and decreases the prurigo * It inhibits the formation of allergic diseases of the skin and ceases the seborrhea diseases of oily skin. Example 2 Aerosol intimate deodorant Composition: Cetiol A (fatty alcohol ester formed with oleic acid) 86*0 g Prenylamine lactate 2*0 g Odour 12*0 g 100.0 g Propellant: Freon F 12 The weight ratio of the charge and the propellant is 20:1 * In the above quantity of Cetiol the micronized prenylamine lactate is suspended, then the odour is added and the composition illed into an aerosol flask * Besides the general cosmetic effect the product ensures deodorization and disinfection and decreases the prurigo* It inhibits the for¬ mation of allergic diseases of the skin and can be used for the inhibition of fungoid growth as well as for the prevention of fluxion * Example 3 Aerosol sun— oam Composition: Cetyl alcohol 0.6 g Glycerol 5-0 g Isopropyl myristate 1.4 g Stearic acid 5.1 s Myristic acid 1.2 g Triethanolamine 3.0 g ■ p Parasol Ultra (light pro¬ 2.8 g tecting produc , pro¬ duced by the firm Givaudan) Odour 0.4 g ¥ater 80.0 g Prenylamine lactate 0.5 s lOO.O g Propellant; Freon P 12/ll4, The weight ratio of the charge and the propellant is 9:1. At a temperature of about 70 C under stirring the following substances are melt hom¬ ogenized; cetylalcohol, myristic acid, stearic acid and isopropyl myristate. At a temperature of 70 C in the above quantity of water the prenyl- aminc lactate, the glycerol and the trlothanol- εuπine are dissolved, then the thus-obtained sol¬ ution added gradually under constant stirring to the above homogenized mixture. The thus-obtained mixture is cooled to 20 C, the light protecting substance and the odour are added and finally the composition is filled into the aerosol flask* Besides the general cosmetic effects * the product reduces the prurigo of the skin, inhibits the formation of allergic diseases of the skin and exerts a disinfective effect. Example 4 Feet care aerosol Compositio : Polypropyleneglycol (molecular 5.5 s weight = 200) Camphor 1.2 s Menthol 0.4 s Odour 0.5 s Ethanol 91.4 ε Prenylamine lactate 1.0 s 100.0 s Propellant: Freon F 12 The weight ratio of the charge and the propellant is 2:1* In the above quantity of ethanol the prenylamine lactate, the camphor and the menthol are dissolved, then the polypropyleneglycol and the odour are added* The product is filtered and then filled into an aerosol flask* Besides the general cosmetic effect the product inhibits the development of fungoid growth of the skin. It ensures dcodorization and disin— fection and reduces the prurigo of the skin. Example 5 Mouth spray Composition: Ethanol 96,0 g Glycerol 1 * 0 g Prenylamine lactate 1,0 g Odour and flavouring agent 2 #0 g Saccharine (benzosulfimide) in traces 100.0 g Propellant: Fre.on F 12 The weight ratio, of the charge and the propellant is 1:1. In the above quantity of ethanol the basic materials are dissolved at room temperature, then the obtained solution is filtered and filled into an aerosol flask. Besides the general cosmetic effect the product is suitable for the deodorizing and dis- infecting of the mouth. By its use the mouth mycoderm inflammations, the gingivitis, the gums bleeding and the loosening of the teeth can be prevented. The product inhibits the development of carles. Example 6 . Aerosol Composition: Isopropyl myristate 4*0 s Polypropyleneglycol (molecular weight = 200) 1.0 s Glycerol 1.0 s Prenylamine fumarate 4,0 s Ethanol 90.0 s 100.0 s Propellant: Freon P ll4. The weight ratio of the charge and the propellant is 1:1, In the above quantity of ethanol the basic materials are dissolved at room temperature, then the obtained solution is filtered and filled into an aerosol flask. The product inhibits the development of allergic diseases of the skin; it is suitable for the care of a scaly and oily scalp, for de- odorization, disinfection, the inhibition of the development of fungoid growth, the reducing of prurigo and the making symptom—free of urticaria. Example 7 Hair lotion (for oily hair) Composition: Ethanol 45.6 g Glycerol 3*0 g Borax 0.2 g Prenylamine lactate 0,5 S Odour 1,0 g Colour in traces ater ' . 49.7 g 100,0 g In the above quantity of ethanol the above components are dissolved, then the solution is filtered and packed. The product is - besides the general cosmetic effect - suitable for the treatment of a scaly scalp, the regeneration of the hair and the reduction of the prurigo; for disinfection; for the inhibition of the development of fungoid growth and skin allergy; for the inhibition of the static charging up of the hair; for the improvement of the combability of the hair; for the normalization of the pigmentation and for the improvement of inflammatory states of the scalp. Example 8 Toilet soap Composition: Basic soap, 78 percent 94.1 s Lanoline 1.5 T5 s Trilon B (sodium ethylen- 0,8 s diamine tetra- acetate sodium salt) Prenylamine lactate (micronized) 1.5 s Odour 1.8 s Tiranium dioxide 0,3 s 100 * 0 g After the homogenization, milling and the forming into rods the toilet soap is pressed into forms. The product can also be used by indi¬ viduals with a skin oversensitive for soap * It prevents the development of the allergy of the skin* It ensures deodorization and disin ection, reduces the prurigo. It inhibits the development of fungoid growth on the skin and tne infection of the skin* -^Ε Example 9 Tooth-paste Composition: Dicalcium phosphate 33.0 g Aerosil 200 (disperse reactive 2.8 g silicic acid, pro¬ duced by the firm Degussa) Sodium monofluorophosphate 0,1 g Texapon^ ' Z (sodium laurylsulfate 3.1 S Titanium dioxide 0 * 4 g Paraffin oil 1*0 g Carboxymethyl cellulose (12 MP) 1*0 g Saccharine (benzosulfimide) 0.1 g Glycerol , 86 percent 17.0 g Sorbitol, 70 percent 10,0 g Odour and flavouring agent 2 * 0 g Prenylamine lactate 0,9 S Water 28.6 g 100.0 g In a quarter of the necessary quantity of water the saccharine and the prenylamine lac- tate are dissolved, then the solution is heated to 80 C, the carboxymethyl cellulose is added and within about 1.5 hour it is cooled to 25 C under constant stirring. The sodium raonofluorophos- phate is dissolved in the rest of water, then it is admixed to the previous phase. The glycerol, the paraffin oil, the sorbitol, then the dical¬ cium phosphate, the Aerosil, the Tcxapon, the titanium dioxide and finally the odour are added to the thick gel. The mixture is homogenized to a lump-free state, de-aerated in vacuo and filled into tubes * Besides the general cosmetic effect the product is suitable for the inhibition of mouth mycoderm inflammations, gingivitis, dis¬ in ection, deodorization, the prevention of gums bleeding, caries and the loosening of teeth, Example 10 Shampoo Composition: ■ p C Ciikklloonnaatt R MMA (27 percent sodium 6l*0 lauryl ethersul ate) Cocoanut fatty acid diethanol- 1 * 0 g amide Polyglycolether (molecular 5.0 g weight = 200) I Perglanc (concentrated fatty 4.0 g alcohol ethersulfate) Odour 1.2 g Colourant in traces Water 26.8 g Prenylamine lactate 1.0 g 100.0 g At a temperature of 4θ C in two thirds of the given quantity of water the prenylamine, the Ciklonat, the polyglycolether, the cocoanut fatty acid diethanolamide, then under constant stirring the Perglanc. concentrate suspended in the residual water are dissolved. The temperature is reduced to 20 C under stirring and the odour ■ Ts_ and the colourant are added* Besides the general cosmetic effect the product can be used for the inhibition of the allergy of the skin, against seborrhea, for the prevention of prurigo, disinfection, the elim- • inat,ion of the development of fungoid growth, the regeneration of the hair and the inhibition of the static chargin -up of the hair, fur- thermore for the speeding-up of the growth and the pigmentation of the hair* It inhibits the development of inflammatory diseases of a sen¬ sitive or oily scalp. Example H Foam bath Composition: τ> Genapol CRO (27 percent sodium 68„ 5 S lauryl ether- sulfate) Cocoanut fatty acid diethanol- 2,0 g amide Odour 1 * 5 S Colourant in traces Water 26,0 g Prenylamine lactate 2.0 g 100,0 g The product is prepared from the com¬ ponents as described in Example 11* Besides the general cosmetic effect it can be used for the reduction of the prurigo, for the elimination of the allergy of the skin, for disinfection and against the development of fungoid growth. Example 12 Shaving cream (rapid) Composition: Stearic acid 25.0 s Cetyl alcohol 1.0 s Isopropanolamine 2.0 s Glycerόl 5.0 c Odour 6.5 s Water 65.8 s Prenylamine lactate 0.7 s 100.0 s The product is prepared in two phases. In the first the above quantity of stearic acid, then heated to 70 C, forms the first phase* The cetyl alcohol, the isopropanolamine, the glycerol and the prenylamine lactate are dissolved in the necessary quantity of water while the temperature is raised to 70 C under constant stirring* So the second phase is obtained* Then at identical temperature under constant stirring the second phase is added to the first phase. T Thhee pprroodduucctt iiss cooled gradually to 30 C and the odour is added. Besides the general cosmetic effect the product can be used for disinfection, the inhibition of the development of fungoid growth, the reduction of prurigo and the elimination of the allergic reaction of the skin. Example 13 Milk cream Composition: Hidrocet (hydrogenated sperm 29 * 0 g oil) Potassium carbonate 5.9 S Stearic acid 156*0 g Vaseline oil 45.0 g Sorbitol, 70 percent * 67.5 g Odour 4,0 g Prenylamine lactate 0*8 g Water 692.1 g 1000.0 g The product is prepared in two phases, When preparing the first phase the Hidrocet, the vaseline oil and the stearic acid are homogenized at a temperature of 80 C* When forming the sec- ond phase the water, the potassium carbonate and the sorbitol solution are homogenized at 80 C, At the same temperature under stirring the sec¬ ond phase is added to the first phase, then at 6θ C under constant stirring the prenylamine lactate and at a temperature of about 0 C the odour are added. The product is suitable for the treat¬ ment of oversensitive skin. It inhibits the do- velopment of the allergy of the skin and reduces the prurigo, O PI Example lZj. Hand care cream Composition: Cetyl alcohol 1. , 6 s Stearic acid 8 , , 2 e Cholesterol 0, .9 s Vaseline 5 * , 3 s Vaseline oil 7. , 0 s Glycerol 8, .7 s Triethanolamine 1. , 1 € Silicone oil NM 1-300 0, 3 s Odour 0. .5 G Water 65. , 6 S Prenylamine lactate 0. , 8 S 100, , 0 s The product is prepared in two phases. When preparing the first phase the above quan- tity of vaseline oil, vaseline, cetyl alcohol, stearic acid and cholesterol are mixed together at a temperature of 80 C, When preparing the second phase water, triethanolamine, glycerine and prenylamine lactate are homogenized at 80 C. At the same temperature the second phase is ad¬ mixed to the first phase, then the product is cooled to 30 C and the odour is added. The ob¬ tained cream is homogenized and de-aerated in vacuo. The product is suitable for tranquil¬ lizing sensitive skin, preventing the allergy of the skin, reducing the prurigo and for dis¬ in ection. Example 1 Hydrating cream Composition: Diethanolamine cetyl phosphate 1, . 6 s Stearic acid 9. .7 s Stearoyl monoglyceride 5. , 0 s Cetyl alcohol 1, , 0 s Oleil alcohol 4. , 0 s Sorbitol, 70 percent solution 6. , 0 s Sorbic acid 0, , 1 s Isopropyl myristate 8. , 0 s Odour 0. 5 s Water 63*. 3 s Prenylamine lactate 0. 8 s 100. 0 s The pro uct is prepared in two phases. When preparing the first phase the following components are homogenized at a temperature of 80 C: isopropyl myristate, oleil alcohol, diethanolamine cetyl phosphate, cetyl alcohol, stearic acid and stearoyl monoglyceride. When preparing the second phase the water, the sorbitol solution and the prenylamine lactate are homogenized at 80 C, too. The sec¬ ond phase is admixed still warm to the first phase, the mixture is cooled to 0 C, the odour is added, homogenized, then the obtained cream is deaerated in vacuo. Besides the general cosmetic effect the product inhibits the development of the allergy of the skin, tne development of fungoid growth on the skin and reduces the prurigo. Example 16 Baby cream Composition: Water 35. , 7 s Cetyl alcohol 5- ,5 ε Ceresine (distillation product 3. , 1 ε of mineral oil) White vaseline 25, ,0 ε Vaseline oil 5 t , 0 ε Tween 6θ (polyoxyethylene 5 * .5 s sorbitanmonostearate 0) Lanoline p 5. ,0 ε Hydroricine (hydrogenated 5 * ,0 ε castor oil) Isopropyl myristate 9 * < 5 ε Aluminium monostearate 0, ,2 ε Odour 0. , 1 s Prenylamine lactate 0, 5 ε 100, ,0 ε The product is prepared in two phases. When preparing the first phase the following components are homogenized at a temperature of 80 C: aluminium monostearate, ceresine, Hydro¬ ricine, cetyl alcohol, lanoline, isopropyl myristate, white vaseline, Tween 60, and vaseline oil. Then the components of the aqueous phase are homogenized at 80 C: the prenylamine lactate is dissolved in water. The aqueous solution is added under stirring still warm to the first, fat-like phase, after the homo eniza ion the mixture is cooled to 0 C, the odour is added, homogenized, finally the cream is deaerated in vacuo. Besides the general cosmetic effect the product is suitable for disinfection, for the reduction of the oversensitivity of the skin, the inhibition of the prurigo. It reduces the reddening of the skin and exerts a deodorizing effect, too. It reduces, the tendency to stoma- tomycosis* Example 17 Fatty cream Composition; Stearoyl monoglyceride 7.0 £ • Stearic acid 4,0 & Isopropyl myristate 20,0 ε Eutanol G (octyl dodecanol) 6.0 ε Lanoline 8.0 e Water 49.0 s Hydroviton (a moisture-re¬ 2,5 e taining material con¬ taining amino acid, produced by the firm Dragoco) Triethano1amine 2.0 s Polyvinyl pyrrolidone 0.2 e Odour 0.3 e Prenylamine lactate 1.0 ε 100 * 0 ε At irst at a temperature of 80 C the components of the fatty phase are admixed: the stearoyl monoglyceride, the stearic acid, the Eutanol G, the lanoline and the isopropyl myri- state* The components of the aqueous phase are homogenized at 80 C, too: the water, the Hydro- viton, the triethanolamine, the polyvinyl pyrroli- done and the prenylamine lactate. The aqueous phase is admixed still warm under stirring to the fatty phase, the mixture is cooled to 30 C, the odour is added, the mixture is homogenized, finally the cream is deaerated in vacuo, Besides the general cosmetic effect the product inhibits the allergy of the skin and the development of fungoid growth. It is suitable for deodorizing, the reduction of the sensitivity of the skin, the inhibition of the -prurigo and dis¬ infection. Example l β Mouth wash * _ Composition: Ethanol, 6 percent 745,0 g Myrrh tincture (a 10 ^ e hanolie 5,0 g solution) Phenyl salicilate 2,5 g Sodium saccharate 1 * 5 g Prenylamine lactate 30*0 g Odour and flavouring agent 26,0 g Distilled water 190.0 g 1000,0 g At room temperature in the above quan¬ tity of ethanol the prenylamine lactate is dis¬ solved, then the myrrh, the phenyl salicilate and the odour are added. The sodium saccharate is dissolved in water, under stirring the aqueous solution is added to the alcoholic solution, finally the mixture is filtered* Besides the general cosmetic effect the product is suitable for the inhibition of the mouth mycoderm inflammations and gingivitis, for disinfection, for deodorizing the mouth cavity and the prevention of the gums bleeding * -3UUE O PI

Claims: What is claimed is : 1* A cosmetic composition c h a r a c - t e r i z e d in that it contains 3 j 3-<ϋphenyl— propyl-l-methyl-phenetylamine or an acid addition salt thereof * 2. A cosmetic composition as claimed in claim 1, c h a r a c t e r i z e d in that it contains 3 . 3-d.iphenylpropyl-l-methyl-phenetyl- amine lactate. 3. A cosmetic composition as claimed in claim 1, c h a r a c e r i z e d in that it contains 3»3-ϋphenylpropyl-l-methyl-phenetyl- amine fumarate. 4. A cosmetic composition as claimed in claim 1, c h a r a c t e r i z e d in that it contains 0.05 to 8.0 percent by weight of 3 . 3- -diphenylpropyl-1-methyl-phenetylamine or an acid addition salt thereof, 20 to 99 percent by weight of a solvent or solvents, 0 to 70 percent by weight of wash-active material or materials and/or an emulsifying agent or agents, 0 to 20 percent by weight of a cosmetic additive or additives and 0 to 35 percent by weight of a filling agent and optionally a propellant, the weight ratio of the product to be sprayed to the propellant is from 1:1 to 20:1. 5 * A tooth-paste, c h a r a c t e r ¬ i z e d in that it contains 0.05 to 8 ^ 0 percent by weight of - 3-ϋphenyl-l-methylphenetylamine or an acid addition salt thereof together with the usual components of tooth-pastes* 6. A mouth-wash, c h a r a c t e r - i z e d in that it contains 0,05 to 8*0 percent by weight of 3 j 3-<ϋphenylpropyl-l-methyl-phenetyl- amine or an acid addition salt thereof together with the usual components of mouth-washes * 7. A deodorant, c h a r a c t e r ¬ i z e d in that it contains 0*05 to 8 * 0 percent by weight of 3 . 3-diρhenylpropyl-l-methyl-phenetyl- amine or an acid addition salt thereof together with the usual components of deodorants. 8 * A process for the preparation of the cosmetic composition according to claim 4, c h a r a c t e r i z e d in that 0.05 to 8.0 percent by weight of 3 . 3-<iiphenylpropyl-l-methyl- -phenetylamine or an acid addition salt thereof are dissolved in a solvent or a solvent mixture, optionally it is admixed with further solvent or solvents to a total quantity of 20 to 99 percent by weight of solvent, it is admixed with altogether 0 to 70 percent of wash-active agent or agents and/or emulsifying agent or agents, 0 to 20 percent by weight of cosmetic additive or additives and 0 to 35 percent by weight of filling agent or , agents and filled into package units generally used for the package of cosmetic products.

Inventors: BOROS KALMAN, CSAKVARI GABOR, GYARMATI ISTVAN, SZATLOCZKY ERNOE, ZALAY LASZLO, BOROS, KALMAN, CSAKVARI, GABOR, GYARMATI, ISTVAN, SZATLOCZKY, ERNOE, ZALAY, LASZLO
Applicants: CAOLA KOZMETIKAI, CAOLA KOZMETIKAI ES HAZTARTAESVEGYIPARI VALLALAT
Application year: 1982
Main classification: A61K7
IPC codes: A61K8, A61K31, A61Q5, A61Q7, A61Q9, A61Q11, A61Q15, A61Q17, A61Q19, C11D3