PREPARATION OF NITROARALKYL CYANIDES AND DERIVATIVES THEREOF

Abstract: Nitroarylalkyl cyanides may be prepared in a con­ venient manner by reacting a nitroaromatic compound with an alpha, alpha-disubstituted alkyl cyanide e.g. an alpha, apha-disubstituted acetonitrile, in a substantially anhydrous aprotic solvent and in the presence of a hase so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic com­ pound during which an alpha-subsituent functions as a leaving group. The nitroaralkyl cyanides formed by the process can be readily converted into derivatives, such as pharmaceuticals.

Description: PREPARATION OF NITROARALKYL CYANIDES AND DERIVATIVES THEREOF This invention relates to the preparation of nitroaralkyl cyanides and derivatives thereof. There are known techniques of preparing profentype pharmaceuticals and other materials having a relatively complex aryl group attached to the alphacarbon of a substituted or unsubstituted acetic acid. For example, U. S. patents 3,755,427 (Adams et al.), 3,959,364 (Armitage et al.), and 4,278,516 (Zaiko et al.) disclose processes for converting various starting materials into flurbiprofen, i.e., 2-(2-fluoro-4biphenylyl)propionic acid, and similar compounds having anti-inflammatory, analgesic, and anti-pyretic properties; Carney et al., "A Potent Non-Steroidal Anti-Inflammatory Agent: 2-[3-Chloro-4-(3-pyrrolinyl)phenyl]propionic Acid," Experientia, Vol. 29, page 938 (1973) teach, inter alia, the preparation of their anti-inflammatory agent - also known as pirprofen - via an ethyl 2-(3-chloro-4-nitrophenyl)propionate intermediate; U. S. Patent 4,239,901 (Rainer) shows that pyrazol-l-ylphenyl and pyrazolin-l-ylphenylacetic acids having anti-inflammatory properties can be synthesized from various intermediates, including polychloronitrophenylacetic acid esters; and it is known that indoprofen, i.e., 2-[4-(1,3-dihydro-1-oxo-2H-isoindol- 2-yl)phenyl]propionic acid, and indobufen, i.e., 2-[4-(l,3-dihydro-l-oxo-2H-isoindol-2-yl)phenyl]butyric acid, can be prepared from the appropriate 2-(4-nitrophenyl)-alpha-alkylacetic acids. Nitroarylacetic acids and their esters and nitriles, as well as the amino derivatives thereof, have been found to be particularly useful intermediates for the synthesis of these pharmaceuticals. However, in the past, a disadvantage of employing them as pharmaceutical intermediates has been the difficulty of preparing them by conventional techniques. Even the preferred procedures for preparing them have proven to be difficult, tedious, and time-consuming, as evidenced by Example 23 of U. S. Patent 3,868,391 (Carney et al. II) and Example 16 of Rainer, both of which show the use of days of refluxing to accomplish only a portion of their syntheses. It would obviously be a welcome contribution to the art to provide a method of synthesizing nitrophenylalkyl cyanides and analogs and derivatives thereof in a simple and straightforward manner. This invention alias to provide processes for preparing nitroaralkyl cyanides in moderate-to-good yield with high selectivity in a simple and straightforward manner. In addition, novel processes for preparing derivatives of the cyanides are provided. The invention provides a process comprising reacting a nitroaromatic compound with alpha, an alpha-disubstituted alkyl cyanide, e.g. an alpha, alpha-disubstituted acetonitrile, in a substantially anhydrous aprotic solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution onan unsubstituted ring carbon of the nitroaromatic compound during which an alphasubstituent functions as a leaving group, thereby forming a nitroarylacetonitrileand, when appropriate, converting the nitroarylacetonitrile to a desired derivative thereof. The invention aslo provides certain novel cyanides useful as intermediates for the preparation of pharmaceuticals. Nitroaromatic compounds utilizable in the practice of the invention include a variety of such compounds - the chief requirements for their utility being that (1) they bear at least one nitro substituent on an aromatic ring, (2) they contain at least one replaceable hydrogen on an aromatic ring to which a nitro group is attached, and (3) they be devoid of substituents which would interfere with the desired nucleophilic substitution reaction, e.g., substituents bearing an acidic proton, such as -NH2, -OH, -SH, -NHR, etc. Thus, the utilizable nitroaromatic compounds include compounds having one or more simple or fused aromatic rings containing five or six members and either bearing no substituents other than nitro substituents or also bearing any of a variety of inert substituents, i.e., substituents that do not interfere with the desired nucleophilic substitution reaction, such as halo, alkyl, alkoxy, alkylmercapto, trifluoromethyl, dialkylamino, dialkanoylamino, cyano, dialkylcarbamoyl, alkylsulfonyl, dialkylsulfamoyl, alkoxyalkyl, haloalkyl, cycloalkyl, halocycloalkyl, etc, - any alkyl chains in the substituents generally being lowersalkyl chains. When the nitroaromatic compound contains more than one ring, any such inert substituent may be on the same ring as the ring bearing a nitro substituent and/or on a ring which is directly or indirectly attached to the ring bearing a nitro substituent. When the aromatic ring bearing the required nitro substituent is a six-membered ring, there will be at least one replaceable hydrogen in a position para or ortho to the carbon bearing the nitro substituent; and it is preferred that there be a replaceable hydrogen in the para position. Nitroaromatic compounds having a five-membered ring should have a replaceable hydrogen on a carbon adjacent to, or separated by two ring atoms from, the carbon bearing the nitro substituent. In accordance with one embodiment of the invention, the nitroaromatic compound is a compound which is devoid of halogen on the aromatic ring bearing the required nitro group. Illustrative of such compounds are heterocyclic compounds which preferably contain five or six-membered rings having aromatic character, such as nitropyridine-N-oxide, 5-nitroisoquinoline, 5- and 6-nitroquinolines, 2-nitrothiophene, etc.; fused-ring aromatic compounds, such as the 1- and 2-nitronapthalenes, etc.; aromatic compounds containing a plurality of simple rings, such as the 2-, 3-, and 4-nitrobiphenyls, the 2-, 3-, and 4-benzylnitrobenzenes, 2-nitrodiphenyl ether, etc.; and aromatic compounds containing a single simple ring, such as nitrobenzene, 2-methylnitrobenzene, the 2,3-, 2,5-, and 3,5-dimethylnitrobenzenes, the 2,4- and 2,6-diethylnitrobenzenes, 3,4-dibutylnitrobenzene, the 1,2- and 1,3-dinitrobenzenes, 2,6-dinitrotoluene, the 1,2,3- and 1,2,4-trinitrobenzenes, 2-nitro-N,N-diethylaniline, 4-nitro-N-ethylacetanilide, 2-nitrobenzylcyanide, 2-nitrophenyl acetate, etc. In accordance with another embodiment of the invention, the nitroaromatic compound is a compound which bears at least one halo substituent on the aromatic ring bearing the required nitro group. Exemplary of such compounds are the 2-, 3-, and 4-chloronitrobenzenes; the 2,3-, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5-dichloronitrobenzenes; the various trichloronitrobenzenes; the corresponding fluoro, bromo, and iodo compounds; the various dimethyl-, diethyl-, and dibutylnitrobenzenes, nitrobiphenyls, benzylnitrobenzenes, nitronaphthalenes, di and trinitrobenzenes, nitro-N,N-diethylanilines, nitrodiphenyl esters, nitro-N-ethylacetanilides, nitrobenzylcyanides, nitrophenyl acetates, nitropyridine-N-oxides, nitroquinolines, nitroisoquinolines, nitrothiophenes, and the like bearing one or more ar-chloro, fluoro, bromo, or iodo substituents and containing at least one replaceable hydrogen in an appropriate position. In some cases, polynitroaromatic reactants may undergo substitution reactions whereby one of the nitro groups is replaced by the nitrile reactant. Therefore, the possibility of this competitive reaction should be kept in mind when selecting a polynitroaromatic reactant for use in the process. In each of the aforementioned embodiments of the invention, the preferred nitroaromatic compounds are nitrobenzenes having a replaceable hydrogen in the position para to the nitro group, since the nucleophilic substitution reaction of the invention tends to be highly selective on the para position, and the use of such compounds therefore leads to the production of nitrophenylacetonitriles which are ideally suited for the synthesis of anti-inflammatory agents of the type described in the aforementioned references. Even more preferred in the case of the halonitrobenzenes are such nitrobenzenes having a halo substituent in a position ortho to the nitro group. Halonitrobenzenes which are especially preferred are 2-chloronitrobenzene and 2-fluoronitrobenzene which are readily converted with high selectivity into such products as 2-[3-chloro-4-(3-pyrrolinyl)phenyl]propionic acid, 2-(2-fluoro-4-biphenylyl)propionic acid, and related anti-inflammatory agents. A non-halogenated nitroaromatic compound that is particularly preferred is nitrobenzene, which is readily converted with high selectivity into pharmaceutically-active agents such as 2-[4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)phenyl]- propionic acid, 2-[4-(1,3-dihydro-1-oxo-2H-isoindol- 2-yl)phenyllbutyric acid, and analogs thereof. The alpha, alpha-disubstituted acetonitriles that can be used in the practice of the invention also include a variety of such compounds, which - in general may be represented by the formula: EMI8.1 wherein L is a leaving group and R is halo (preferably chloro) or, more preferably, a hydrocarbyl (e.g., alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl, etc.) or hydrocarbyloxyhydrocarbyl (e.g., alkoxyalkyl, aryloxyalkyl, alkoxyaryl, alkoxycycloalkyl, etc.) group which most preferably contains up to about 10 carbons. Exemplary leaving groups, L, include halo, aryloxy, haloaryloxy, alkylthio, cycloalkylthio, arylthio, aralkylthio, haloalkylthio, halocycloalkylthio, haloarylthio, haloaralkylthio, or, less preferably, alkoxy, cycloalkoxy, aralkoxy, haloalkoxy, halocycloalkoxy, haloaralkoxy, and the like, as well as other suitable leaving groups which have been described in the literature, e.g., in Golinski et al., "'Vicarious' Nucleophilic Substitution of Hydrogen in Aromatic Nitro Compounds,"Tetrahedron Letters," Vol.37, pp. 3495-8 (1978) and in Makosza et al., "Vicarious Substitution of Hydrogen in Aromatic Nitro Compounds with Acetonitrile Derivatives," Journal of Organic Chemistry, Vol. 45, pp. 1534-5 (1980). When the leaving group is an organic group, it is generally preferred that it contain not more than about 10 carbons, although organic leaving groups having an even higher carbon content are satisfactory in the practice of the invention. Preferably the leaving group is halo, i.e., chloro, bromo, fluoro, or iodo; and it is more preferably chloro or bromo, most preferably chloro. It is notable that acetonitriles having a single alpha-substituent do not appear to be equivalent to the aforementioned alpha, alpha-disubstituted acetonitriles in the preparation of nitroaralkyl cyanides by a nucleophilic substitution reaction. For example, attempts to prepare substitution products by reacting alpha-chloroacetonitrile with nitrobenzene have not been successful thus far, and Makosza et al. teach that they were also unsuccessful in reacting alpha-chloroacetonitrile with 4-nitrobiphenyl, although that nitrile did react with l-nitronaphthalene and 4-chloronitrobenzene to form the corresponding alpha-nitroaryl acetonitr iles. A few examples of alpha, alpha-disubstituted acetonitriles that can be used in the practice of the invention are 2-chloropropionitrile, 2-chlorobutyronitrile, 2-chlorovaleronitrile, 2-chlorocapronitrile, 2-chloro-4-pentenenitrile, 2-chloro-3,3-dimethylbutyronitrile, 2-chloro-2-phenylacetonitrile, 2-chloro-2 cyclohexylacetonitrile, 2-chloro-3-(3-chloro-o-tolyl)propionitrile, 2-chloro-3-phenylpropionitrile, the corresponding bromo and iodo compounds, and the like. The alpha-halo-alpha-hydrocarbylacetonitriles, i.e., alpha-haloalkyl cyanides containing at least three carbons - particularly 2-chloropropionitrile and 2-bromopropionitrile - are especially preferred, although similar cyanides in which the alpha-halo substituent is replaced by one of the other leaving groups mentioned above are also highly desirable. In another highly desirable embodiment of the invention, the alpha, alpha-disubstituted acetonitrile is an alpha, alpha-dihaloacetonitrile, most preferably an alpha, alpha-dichloroacetonitrile, which leads to the formation of a product having a reactive halo substituent in the alpha-position, e.g., a product corresponding to the formula: EMI10.1 wherein X is halo, preferably chloro, and n is an integer of 1 to 3. Such products enable facile synthesis of a variety of end products. Most preferably the nitro group is in the position para to the nitrile substituent, although it may be located in an ortho position. Illustrative aprotic solvents which may be employed in the process of the invention include ethers such as diethyl ether, dibutyl ether, l-ethoxybexane, tetrahydrofuran, 1,4-dioxane, 1,3-dioxolane, diglyme, 1,2-diethoxyethane, anisole, etc.; tertiary amines such as pyridine, N-ethylpiperidine, triethyl amine, tributyl amine, N,N-diphenyl-N-methyl amine, N,Ndimethylaniline, etc., and other solvents. However, the preferred aprotic solvents are dipolar aprotic solvents such as dimethyl sulfoxide, N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfone, tetramethylene sulfone, N-methylpyrrolidone, and the like. Bases useful in the practice of the invention include all bases strong enough to activate the nitrile reactant, e.g., alkaline earth metal compounds such as calcium oxide, calcium hydride, calcium hydroxide, barium oxide, barium hydroxide, magnesium hydroxide, zinc hydroxide, etc. However, the base is preferably an alkali metal compound, e.g., an organoalkali metal compound, alkali metal hydride, alkali metal hydroxide, alkali metal oxide, alkali metal amide, or alkali metal alcoholate, such as butyllithium, phenyllithium, ethylsodium, amylsodium, butylpotassium, benzylpotassium, sodium dimsylate (i.e., the sodium salt of diethylsulfoxide), sodium hydride, potassium hydride, sodium hydroxide, potassium hydroxide, sodium oxide, potassium oxide, sodium amide, potassium amide, lithium diisopropylamide, sodium methoxide, potassium t-butoxide, the sodium salt of the monomethylether of ethylene glycol, sodium phenoxide, and the like. Ordinarily the use of sodium hydride or potassium hydride will be found most convenient and economical. Use of an alkali metal compound as the base permits the alternatives of using the alkali metal compound alone or in conjunction with a phase transfer catalyst, such as a quaternary ammonium salt, ethylene glycol, or a suitable crown ether. When a phase transfer catalyst is employed (1) the alkali metal compound may be any of the alkali metal compounds generically or specifically indicated above, although the type of alkali metal compound being used determines the type of crown ether that is preferably utilized lithium bases generally calling for the use of a 12-crown-4 ether, sodium bases usually calling for the use of a 15-crown-5-ether, and potassium bases generally calling for the use of an 18-crown-6-ether, and (2) the reaction medium may be any of the aprotic solvents mentioned above, or it may be an inert liquid hydrocarbon such as benzene, toluene, xylene, hexane, heptane, isooctane, or the like. When an alkali metal hydride, especially a highly pure alkali metal hydride, is employed as the base, it is desirable to include a small amount of a transfer agent such as water, alcohol, or the like in the system. It is believed that the transfer agent activates the hydride by reacting therewith to form a small amount of the alkali metal hydroxide or alcoholate. The nitroaralkyl cyanide synthesis of the invention is conducted in a substantially anhydrous reaction system, and accordingly, except when a small amount of water (which is itself consumed by reaction with the alkali metal hydride) is employed as a transfer agent, the components of the reaction system should be brought together and maintained under a dry inert atmosphere. Thus, while it is possible to conduct the process in the presence of air, it is desirable to maintain the reaction system under an atmosphere of dry nitrogen or the like. Since the reaction itself is normally an exothermic reaction, with its initiation readily ascertainable by noting the exotherm produced, the reactants are ordinarily brought together at ambient temperatures, although the temperature may be raised or lowered to suit the needs of the occasion if desired. The nitroaromatic compound and alpha,alphadisubstituted acetonitrile may be used in amounts such as to provide a stoichiometric excess of either of the reactants or the stoichiometric amount of each. However, when a stoichiometric excess of the nitroaromatic compound is employed, the quantity of product obtainable will be limited by the quantity of nitrile used, so it is desirable to utilize a stoichiometric excess of the nitrile. The amount of base employed is preferably such as to provide at least two molar equivalents of base per mol of nitroaromatic compound, since the use of smaller amounts - although permitting the reaction to occur - makes the base the limiting reagent. The mode of addition of the ingredients of the reaction system is not particularly critical. Accordingly, it is convenient to add the nitroaromatic compound to a mixture of the other materials, add the base to a mixture of the other materials, add the reactants to a mixture of the base and aprotic solvent, introduce all four ingredients simultaneously into the reaction zone, or the like. Since the reaction ordinarily proceeds very rapidly, long reaction times are not required. The reaction will usually be completed within a matter of minutes or a few hours at ambient temperatures. When derivatives of the nitroaralkyl cyanides are desired, they may be prepared by employing conventional techniques to convert to the desired derivatives the nitroaralkyl cyanides made in accordance with the present invention. Thus, for example: (A) 2-(4-nitrophenyl)propionitrile synthesized by the process of the invention may be hydrolyzed to 2-(4-nitrophenyl)propionic acid, which in turn may be hydrogenated to 2-(4-aminophenyl)propionic acid, reacted with phthalic anhydride to form 2-(4-phthalimidophenyl)propionic acid, and reduced to indoprofen, (B) 2-(4-nitrophenyl)propionitrile synthesized by the process of the invention may be hydrogenated to 2-(4-amino-phenyl)propionitrile, hydrolyzed to 2-(4-aminophenyl)propionic acid, reacted with phthalic anhydride to form 2-(4-phthalimidophenyl)propionic acid, and reduced to indoprofen, (C) 2-(4-nitrophenyl)propionitrile synthesized by the process of the invention may be hydrogenated to 2-(4-aminophenyl)propionitrile, reacted with phthalic anhydride to form 2-(4-phthalimidophenyl)propionitrile, and hydrolyzed and reduced (in either order) to indoprofen, (D) 9-24-nit-ophenyl)butyrcr.itrile synthesized by the process of the invention may be subjected to the same reactions to prepare indobufen or indobufen intermediates, (E) 2-(3-chloro-4-nitrophenyl)propionitrile synthesized by the process of the invention may be reduced to 2-(4-amino-3-chlorophenyl)propionitrile, reacted with a 1,4-dihalo-2-butene to form 2-[ 3-chloro-4- (3-pyrrolinyl)phenyl]propionitrile, and then converted into 2-[ 3-chloro-4- (3-pyrrolinylphenyl] - propionic acid, and (F) 2-(3-fluoro-4-nitrophenyl)propionitrile synthesized by the process of the invention may be reduced to 2-(4-amino-3-fluorophenyl)propionitrile, converted into (2-fluoro-4-biphenylyl)propionitrile by means of a Gomberg-Bachmann reaction with benzene, and then converted into 2-(2-fluoro-4-biphenylyl)propionic acid. The particular conventional techniques used to convert the nitroaralkyl cyanides into their various derivatives are not critical. It may sometimes be desirable to use certain particular techniques for the preparation of the derivatives, e.g., (a) the reduction and/or hydrolysis techniques taught in March, Advanced Organic Chemistry, McGraw-Hill, New York, 1977, pages 809-10, 1125-6, and the references cited therein, (b) the Gomberg-Bachmann techniques taught in March, pages 653-4, and in Orqanic Reactions, Vol. 2, page 224 (1944); Journal of the American Chemical Society, Vol. 46, page 2339 (1924); Chemical Rev. Vol. 57, page 77 (1957); and Journal of the Chemical Society, Vol. D 1971, page 411, and (c) the techniques taught in Adria Laboratories, Inc.'s NDA on Indoprofen Capsules, Section No. 8(c), pages 2-11, which is on file with the Federal Drug Administration. However, the overall processes for preparing the derivatives are simplified and made more efficient and economical by the present simplification of the synthesis of the nitroaralkyl cyanides regardless of the particular techniques used to convert them into their various derivatives. The invention includes pharmaceutical or veterinary formulations comprising those of said derivatives which have therapeutic activity, in each case said derivative being formulated for pharmaceutical or veterinary use, respectively. As indicated, the present invention is particularly advantageous in providing a readier and more economical route to the synthesis of pharmaceuticals and other chemical products that can be prepared from nitroaralkyl cyanides. Such products include, not only those mentioned above, but a variety of products, such as products disclosed in U.S. Patents 3,641,040, 3,657,230, 3,767,805, 3,868,391, 3,936,467, 3,993,763, 3,997,669, 4,010,274, 4,118,504, 4,126,691, 4,163,788, and 4,239,901. The following Examples are gIven to illustrate the invention and are not intended as a limitation thereof. Example I Into a flame dried flask under nitrogen was placed 1.3 grams (0.026 mol) of NaH (50% dispersion in mineral oil). This was washed twice with 10 ml portions of petroleum ether (b.p. 35-600C) and dried in a nitrogen stream. Then 25 ml of N,N-dimethyl- formamide (DMF; dried over 3 Angstrom molecular sieves) was added followed by dropwise addition (over 20 minutes) of a solution of 2.2 ml (0 021 mol) of 2-fluoronitrobenzene and 1.9 ml (0.023 mol) of 2-chloropropionitrile in 10 ml of DMF. The mixture became red and hot during the dropwise addition. A small portion of the reaction mixture was worked up by partitioning between 1N HC1 and diethyl ether, and analysis of the ether layer by gas chromatography (GC) indicated some starting material had not reacted. A second (0.40 g, 0.008 mol) and third (0.80 g, 0.017 mol) portion of 50% NaH were added so that workup of a reaction mixture sample followed by GC analysis indicated that no starting material remained. The reaction mixture was poured into 250 ml of 1N HC1 and extracted with six 200 ml portions of ether. The ether layers were combined, dried (MgS04), and concentrated to give a black oil which was adsorbed on 15 g of Silica Gel 60 (230-400 mesh) and loaded on a column of 150 g Silica Gel 60 packed in 40% CH2C12/60% petroleum ether (bp 35-600C). Elution with the same solvent mixture afforded four fractions which, by GC area %, contain 1.8 g (44%) of 2-(3-fluoro-4-nitrobenzene)propionitrile. This compound was characterized by NMR, IR, and mass spectrometry. Example II A slurry of 240 mg (5.0 mmols) of NaH (50% in mineral oil) in 2 ml of pyridine was treated dropwise, under nitrogen, with 0.26 ml (0.35 g, 2.5 mmols) of 2-fluoronitrobenzene followed by 0.22 ml (0.23 g, 2.6 mmols) of 2-chloropropionitrile. The purple reaction mixture was stirred at room temperature under nitrogen for 15 minutes, then was poured into an equal volume of 5% HC1 and extracted with an equal volume of CH2C12. The organic phase was shown by gas chromatography-mass spectral analysis (GC-MS) to contain 2-(3-fluoro-4-nitrobenzene)propionitrile. Example III A solution of 0.61 g (3.1 mmol) of 2-(3-fluoro-4-nitrobenzene)propionitrile in 10 ml of absolute ethanol was treated with 0.03 g of 7% palladium on carbon and hydrogenated at 45 psi of hydrogen (Parr apparatus) for 1 hour. The reaction mixture was filtered and concentrated to give 0.54 g or an oil which darkened on standing. A portion of this oil was purified on 1 mm silica gel plates (developed with CH2C12) to give 2-(4-amino-3-fluorobenzene)propionitrile, which was characterized by NMR, IR, and mass spectrometry. Example IV A solution of 1.2 g (6.2 mmol) of 2-(3-fluoro-4nitrobenzene)propionitrile in 24 ml of absolute ethanol was treated with 0.06 g of 7% palladium on carbon and hydrogenated at 40-45 psi hydrogen pressure (Parr apparatus) for 1 hour. The reaction mixture was filtered and the filtrate was shown to contain, by GC analysis (area percent) 99% 2-(4-amino-3-fluorobenzene)propionitrile. Removal of the solvent in a rotary evaporator gave 1.1 gram of a yellow oil which quickly darkened on standing. Example V A solution of 25 mg (0.15 mmol) of 2-(4-amino-3fluorobenzene)propionitrile, 0.2 ml of benzene, and 0.03 ml (0.25 mmol) of isoamyl nitrite was heated at reflux for 1.5 hours. GC analysis (area percent) of the reaction mixture indicated the presence of 23% unreacted starting material and 60% of a product which was identified by GC-MS to be 2-(2-fluoro-4-biphenylyl) propionitrile. Example VI To a slurry of 0.50 g (10 mmols) of NaH (50% dispersion in mineral oil) in 2 ml of N,N-dimethylformamide (DMF, dried over 3 Angstrom molecular sieves) under nitrogen was added dropwise, over a period of 10 minutes, a solution of 0.60 ml (5.1 mmols) of 2-chloronitrobenzene and 0.42 ml (5.1 mmols) of 2-chloropropionitrile in 1 ml of DMF. During the addition, the mixture became purple and an exotherm was observed. The reaction mixture was stirred under nitrogen for 15 minutes, poured into 30 ml of 1N HC1 and extracted with four 30 ml portions of dimethyl ether. The organic layers were combined, dried using MgS04, and concentrated to give 1.2 g of a black oil. Preparative thin layer chromatography of 0.20 g of this oil (one 2mm silica gel plate developed with 50% CH2C12/50% petroleum ether) afforded 0.088 gram of 2-(3-chloro-4-nitrobenzene)propionitrile which was characterized by means of NMR and mass spectrometry. EXAMPLE VII Into a flask under nitrogen was placed 4.0 g of 60% sodium hydride in mineral oil (0.10 mole). The sodium hydride was washed with three 10 ml portions of petroleum ether (b.p. 35-600C) and was slurried in 50 ml of N,N-dimethylformamide (DMF). A solution of 12.3 g of nitrobenzene (0.10 mole) and 9.0 g of 2-chioropropionitrile (0l0 SO1e) in 10 ini of DMF wes added dropwise to the slurry. An ice water bath was applied to the mixture periodically so that the temperature did not exceed 45 0C. After the addition was complete (30 minutes) the purple mixture was allowed to react for 30 minutes and was poured into 200 ml of cold 10% HC1. The aqueous mixture was extracted with three 100 ml portions of diethyl ether and the ether layers were combined, dried (MgSO4), and concentrated to give a dark oil. Excess nitrobenzene and DMF were removed from this oil at 500C (at 1 mm pressure) and the residue was chromatographed on a column of 400 g of silica gel which was eluted with dichloromethane. A fraction was collected containing 2.9 g of 2-(4-nitrobenzene)propionitrile (16.5% yield). EXAMPLE VIII Into a flame dried flask under nitrogen was placed 500 mg of 60% sodium hydride in mineral oil (12.5 mmole). The sodium hydride was washed with three 5 ml portions of petroleum ether (b.p. 35-600C) and was slurried in 4 ml of N,N-dimethylformamide (DMF). One drop of a solution of 770 mg of nitrobenzene (6.25 mmole) and 600 mg of 2-chloropropionitrile (6.70 mmole) in 1 ml of DMF was added to the sodium hydride slurry to give a deep purple solution. After one minute the mixture was placed in an ice water bath and the rest of the reactant solution was added dropwise. The resulting mixture was stirred at 0 0C for 15 minutes and was poured into 50 ml of lN HC1. The aqueous mixture was extracted with three 40 ml portions of diethyl ether and the ether layers were combined, dried (MgS04), and concentrated to give 880 mg of black oil. Purification of 208 mg of this oil on one 2 mm silica gel plate eluted with 50% dichloromethane/5070 petroleum ether afforded 51.2 mg (20% yield) of 2-(4-nitrobenzene)propionitrile. EXAMPLE IX Into a flame dried flask under nitrogen was placed 176 mg of potassium tert-butoxide (1.57 mmoles), 23 mg of dibenzo 18-crown-6 ether (0.064 mmole), and 1.0 ml of toluene. While this mixture was vigorously stirred in a room temperature water bath a solution of 106 mg of 1,3-dinitrobenzene (0.631 mmole) and 71 mg of 2-chloropropionitrile (0.79 mmole) in 0.5 ml of toluene was added dropwise. The resulting purple mixture was stirred for 15 minutes and poured into 20 ml of IN HCl. The aqueous mixture was extracted with three 20 ml portions of diethyl ether and the ether layers were combined, dried (MgSO4), concentrated, and placed on one 2 mm silica gel TLC plate. One development with 50% petroleum ether (bp35-600C)/50% dichloromethane afforded 10 mg of 1,3-dinitrobenzene (9% recovery) and 25 mg of 2-(2,4-di-nitrobanzene)propionitrile (lveyo yield). The preceding Examples demonstrate the utility of alpha, alpha-disubstituted acetonitriles in the preparation of nitroaralkyl cyanides. The following example shows that similar results are not achieved when an acetonitrile having only one alpha-substituent is substituted for the alpha,alpha-disubstituted acetonitriles. COMPARATIVE EXAMPLE Into a flame dried flask under nitrogen was placed 500 mg of 60% sodium hydride in mineral oil (12.5 mmole). The sodium hydride was washed with three 5 ml portions of petroleum ether (b.p. 35-600C), slurried in 4 ml of N,N-dimethylformamide (DMF), and cooled in an ice water bath. A solution of 770 mg of nitrobenzene (6.25 mmole) and 500 mg of chloroacetonitrile (6.62 mmole) in 1 ml of DMF was added dropwise. The resulting brown mixture was stirred at 0 0C for 15 minutes and was poured into 50 ml of 1N HCl. The aqueous mixture was extracted with three 40 ml portions of diethyl ether and the ether layers were combined, dried (MgSO4), and concentrated to give 1.02 g of black oil. Thin layer chromatographic analysis of this oil revealed no substitution product; only nitrobenzene and an immobile brown spot were observed.

Claims: CLAIMS: 1. A process for preparing a nitroaralkyl cyanide which comprises reacting a nitroaromatic compound with an alpha, alpha-disubstituted alkyl cyanide in a substantially anhydrous aprotic solvent and in the presence of a base so that the cyanide undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. 2. A process as claimed in claim 1, wherein the nitroaromatic compound is devoid of halogen on the aromatic ring carrying the nitro group. 3. A process as claimed in claim 1, wherein the nitroaromatic compound is a halonitroaromatic compound having a halo substituent on the aromatic ring carrying the nitro group. 4. A process as claimed in claim 2 or claim 3, ;. wherein the nitroaromatic compound is a mononitrobenzene having an unsubstituted position para to the nitro group. 5. A process as claimed in claim 4, wherein the mon on itrobenzene is nitrobenzene or an o-halonitrobenzene. 6. A process as claimed in claim 1, wherein the nitroaromatic compound is a chloronitrobenzene, preferably o-chloronitrobenzene. 7. A process as claimed in claim 1, wherein the nitroaromatic compound is a fluoronitrobenzene, preferably o-fluoronitrobenzene. 8. A process as claimed in claim 2 or, in the alternative, as claimed in any one of claims 1 or 3 to 7, wherein the starting cyanide is an alpha-haloalkyl cyanide containing at least three carbons. 9. A process as claimed in claim 3, wherein the halonitroaromatic compound has an aromatic ring substituted by at least one halogen atom having an atomic number above nine and by at least one nitro group and the starting cyanide has at least three carbon atoms in the molecule (exclusive of the alpha-substituent), the resulting nitroaralkyl cyanide being a halonitroaralkyl cyanide. 10. A process as claimed in any one of claims 1 to 9, wherein the starting cyanide is an alpha, alpha disubstituted acetonitrile. 11. A process as claimed in claim 10, wherein the alpha, alphaidisubstituted acetonitrile is an alkyl alpha chloro or- alpha-bromopropionitrile. 12. A process as claimed in any one of claims 1 to 11, wherein the solvent is a dipolar aprotic solvent. 13. A process as claimed in any one of claims I to 12, wherein the base is an alkali metal compound, preferably sodium hydride or potassium hydride. 14. A process as claimed in any one of claims 1 to 13, wherein the nitroaralkyl cyanide is a 2-(4-nitrophenyl)acetonitrile, a 2- (4-nitrophenyl) propionitrile, or a 2-(3-halo-4-nitrophenyl)propionitrile. 15. 2-(3-fluoro-4-nitrophenyl)propionitrile. 16. A process for preparing 2-J-(1,3-dihydro-1-oxo 2H-isoindol-2-yl) pheny)lpropionic acid comprising either: (a) converting 2-(4-nitrophenyl)propionitrile which has been prepared by a process as claimed in claim 14 to 2 (4-aminophenyl)propionic acid either by hydrolyzing the 2- (4-nitrophenyl) propionitrile to 2-(4-nitrophenyl) propionic acid and reducing said acid, or by reducing the 2- (4-nitrophenyl) propionitrile to 2-(4-aminophenyl)- propionitrile and hydrolyzing the 2-(4-aminophenyl)propionitrile, in either case thereafter reacting the 2 (4-aminophenyl)propionic acid with phthalic anhydride to form 2-(4-phthalimidophenyl)propionic acid and reducing the 2- (4-phthalimidophenyl) propionic acid; or (b) reducing 2-(4-nitrophenyl)propionitrile which has been prepared by a process as claimed in claim 14 to 2 (4-aminophenyl) propionitrile, reacting the 2-(4-amunophenyl)- propionitrile with phthalic anhydride to form 2-(4-phthalimidophenyl)-propionitrile, and converting the 2-(4phthalimidophenyl)propionitrile into 2-S- (1, 3-dihydro- l-oxo-2H-isoindol-2-yl) phenyjlpropionic acid either by hydrolyzing the 2- (4-phthalimidophenyl) propionitrile to 2-(4-phthalimidophenyl)propionic acid and reducing said acid, or by reducing the 2- (4-phthalimidophenyl) propionitrile to 2-j- (1, 3-dihydro-l-oxo-2H-isoindol-2-yl) -pheny- propionitrile followed by hydrolysis. 17. A process for preparing 2-t-chloro-4-(3- pyrrilinyl) phenyl] -propionic acid comprising reducing 2- (3-chloro- 4-nitrophenyl)propionitrile which has been prepared by a process as claimed in claim 14 to 2-(4-amino-3-chlorophenyl) propionitrile, reacting the 2- (4-amino-3-chloro- phenyl)propionitrile with a l,4-dihalo-2-butene to form 2-[3-chloro-4-(3-pyrrolinyl)phenyl]propionitrile, and hydrolyzing the 2-E-chloro-4- (3-pyrrolinyl) pheny)l- propionitrile. 18. 2-(4-amino-3-fluorophenyl)propionitrile. 19 A process for preparing 2-(2-fluoro-4biphenylyl)propionic acid comprising reducing 2-(3 fluoro-4-nitrophenyl)propionitrile which has been prepared by a process as claimed in claim 14 to 2-(4-amino-3 fluorophenyl)propionitrile, converting the 2-(4-amino-3- fluorophenyl)propionitrile into 2- (2-fluoro-4-biphenylyl) - propionitrile by means of a Gomberg-Bachmann reaction with benzene, and hydrolyzing the 2-(2-fluoro-4-biphenylyl)propionitrile 20. A pharmaceutical or veterinary formulation comprising 2- (2-fluoro-4-biphenylyl) propionic acid, 2-[3-chloro-4-(3-pyrrolinyl)phenyl]propionic acid or 2- g-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)phenyS propionic acid, formulated for pharmaceutical or veterinary use and prepared by a process as claimed in claim 19, claim 17, or claim 16 respectively. 21. 2-(2-fluoro-4-biphenylyl)propionic acid, 2/25-- chloro-4-(3-pyrrolinyl)phenyl]propionic acid or 2-ff4- (1,3- dihydro-1-oxo-2H-isoindol-2-yl)phenyl]propionic acid, prepared by a process as claimed in claim 19, claim 17, or claim 16 respectively, and for use as a pharmaceutical.

Inventors: STAHLY, BARBARA CLACK, STAHLY, G. PATRICK
Applicants: ETHYL CORPORATION
Application year: 1982
Main classification: C07C121
IPC codes: C07C255