HEXAHYDRONAPHTH(1,2-B)-1,4-OXAZINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATION CONTAINING THEM

Abstract: Hexahydronaphth[1,2-b]-1,4-oxazines have dopaminer­ gic activity and display α₂-adrenergic receptor antagonism. They are useful in the treatment of parkinsonism, depres­ sion and hypertension. An important method of preparation is by ring closure of the appropriate 2-chloroacetamido­ tetrahydronaphthalen-1-ol and reduction of the resulting cyclic amide carbonyl group.

Description: TITLE OF THE INVENTION Hexahydronaphthrl,2-b]-1,4-Oxazines, process for their preparation and pharmaceutical formulation containing them. BACKGROUND OF THE INVENTION The tetracyclic ergoline type of compound (U.S. Patent 3,968,111) has pharmaceutical activity, and the indolobenzoazines (U.S. Patent 4,238,486) in which the D-ring of the ergolines is a tetrahydrooxazines have antihypertensive and antiparkinson activity. SUMMARY OF THE INVENTION This invention is concerned with trans la,2,3,4a,5,6-hexyhydronaphth[1,2-b]-1,4-oxazine and derivatives of structural formula I EMI2.1 and pharmaceutically acceptable salts thereof. The novel compounds demonstrate the dopaminergic activity of antiparkinson and antihypertensive agents. Some of the novel compounds are also a2-adrenergic receptor antagonists and hence antidepressant. It is, therefore, an object of this invention to provide novel compounds of formula I; novel processes for their preparation; novel pharmaceutical formulations comprising one or more of the novel compounds as active ingredient; and novel methods of treating Parkinsonism, hypertension and depression by administration of a novel compound to a patient in need of such treatment. DETAILED DESCRIPTION OF THE INVENTION The novel compounds of this invention have general structural formula I which is used herein to represent the trans-isomers only. EMI2.2 or a pharmaceutically acceptable salt thereof, wherein R is a) hydrogen; b) C1-4 alkyl either branched or straight chain, especially ethyl or propyl; c) C25 alkenyl, especially allyl; or d) phenyl-C1-4 alkyl especially benzyl; and R1, R2, R3 and R4 are independently selected from a) hydrogen, b) C1-4 alkyl, especially methyl, c) halo, such as fluoro, chloro or bromo, d) -OR6 wherein R6 is 1) hydrogen 2) C1-3 alkyl, especially methyl, 3) phenyl-C1-3 alkyl, especially benzyl, EMI3.1 wherein R7 is i) C16 alkyl, either straight or branched chain, such as methyl, t-butyl, or the like, ii) C36 cycloalkyl, such as cyclopropyl, cyclohexyl or the like, iii) benzenoid aryl-C1-3 alkyl, especially phenyl-C1-3 alkyl wherein the aryl group is unsubstituted or substituted with one or more groups such as halo, C1-3 alkyl, or C1-3 alkoxy, iv) heteroaryl-Cl 3alkyl, such as pyridyl- or furyl-C1-3 alkyl, v) benzenoid aryl especially phenyl, either unsubstituted or substituted with one or more groups such as halo, C1-3 alkyl, or C13 alkoxy, vi) heteroaryl such as pyridyl or furyl, and vii) -NR8R9, wherein R8 and R9 are independently hydrogen or C13 alkyl, or R8 and R may be joined together to form a hetero cycle with the nitrogen to which they are attached such as piperidinyl, morpholinyl, piperazinyl, or N-C13alkyl-piperazinyl, and R5 is hydrogen, C1-3 alkyl or phenyl. A preferred embodiment is that wherein R is C14 alkyl especially ethyl or n-propyl, and one or more of R1, R2, R3 and R4 is hydroxy, methoxy, acetoxy or pivaloyloxy especially in the 9-position. The novel compounds of this invention have two asymmetric carbon atoms, 4a and la, where the morpholino ring is fused to the tetrahydronaphthalene ring. This invention includes stereoisomers in which these asymmetric centers are in a trans conformation. The invention further includes the individual enantiomers and mixtures thereof including the racemate. Both enantiomers and mixtures thereof have dopaminergic activity, but the (+)-trans compound is much preferred for that utility. On the other hand, the (-)-trans enantiomer is preferred for a2-adrenergic receptor blockade. The pure optical antipodes can be prepared from the appropriate optically pure intermediates or by resolution of the final racemic product. The pharmaceutically acceptable salts of the novel compound of this invention are acid addition salts formed from a novel compound and an organic or inorganic acid recognized by the art as providing a pharmaceutically acceptable acid addition salt, such as hydrochloride, hydrobromide, dihydrogen phosphate, sulfate, citrate, pamoate, pyruvate, napsylate, isethionate, maleate, fumarate, or the like. These salts are readily prepared by mixing solutions of equimolecular amounts of the free base compound and the desired acid in suitable solvents such as water, alcohols, ether or chloroform, followed by recovery of the product by collecting the precipitated salt or evaporation of the solvent. A novel process for preparing the novel compounds is another embodiment of this invention and is represented as follows: EMI6.1 The novel process comprises the reduction of the oxazinone, II, with a complex metal hydride such as lithium aluminum hydride in an inert organic solvent such as an ether, for example, tetrahydrofuran, l,2-dimethoxyethane, tetrahydropyran, or the like at a temperature between about OOC and 1000C. Operating procedures normally involve slow addition of the cyclic amide to the reducing agent at room temperature or below, followed by heating to an elevated temperature within the stated range, preferably, the reflux temperature of the solvent, for about 1/2 to about 8 hours usually about 4 hours. If, in the novel process of this invention, the nitrogen substituent, R, is hydrogen, and it is desired that it be one of the other substituents within the definition of R the product from the foregoing reaction may be treated with the appropriate alkylating agent of formula: R-X wherein R is as defined earlier and X is a suitable leaving group such as iodo, bromo, chloro, mesylate, tosylate, or the like. The alkylation is conducted in an organic solvent such as DMF, DMSO, or THI?, preferably DMF, at about 10 to about 1000C until the reaction is substantially complete; usually about 3 to 10 hours. If one or more of R1, R3 or R4 is alkoxy, it or they may be converted to hydroxy, if desired, by heating at about 150-2500C in excess pyridine hydrochloride for about 3 to 8 hours. Alternatively, the deetherification can be accomplished by treatment with boron tribromide (BBr3) or aluminum chloride (AlCl3) in an inert organic solvent such as petroleum ether, or hexane, or a chlorinated hydrocarbon such as methylene chloride, tetrachloroethane or the like, between room temperature and reflux temperature for 3 to about 8 hours. Also, if R1, R2, R3 or R4 is benzyloxy or substituted benzyloxy it or they can be converted to hydroxy by hydrogenolysis with a noble metal catalyst such as palladium, platinum, or platinum oxide, with or without a carrier such as carbon, or the like, preferably palladium on carbon, in an inert organic solvent such as C13 alkanol, an ethereal solvent such as tetrahydrofuran, 1,2-dimethoxyethane, or the like, or mixtures thereof. The reaction is conducted at or near room temperature such as 15-300C until hydrogen uptake ceases or the requisite amount of hydrogen is consumed. In those compounds wherein R1, R2, R3 or R4is EMI8.1 they are prepared by treatment of the corresponding hydroxy compound with the appropriate acid anhydride EMI8.2 acid chloride EMI8.3 or the like. in the presence of an acylation catalyst such as pyridine, 4-dimethylaminopyridine or 4-pyrolidinopyridine. Temperatures from about 150C to 1000C are used until the reaction is substantially complete. A third embodiment of this invention is a pharmaceutical formulation comprising one of the novel compounds as active ingredient. It may be in any art-recognized form suitable for oral use, such as tablets, troches, lozenges, aqueous or oil suspensions, dispersible powders, or granules, emulsions, hard or soft capsules, syrups, or elixirs. For intravenous, intramuscular and subcutaneous use the pharmaceutical compositions may be in any art recognized form of a sterile injectable preparation such as a sterile aqueous or oleaginous solution or suspension. The amount of active ingredient incorporated in a unit dosage of the above described pharmaceutical compositions may be from 1 to 400 mg, and preferably from 5 to 250 mg. Other embodiments of this invention are the treatment of hypertension and/or parkinsonism with a compound of Formula I with zero or positive optical activity. The route of administration can be oral, rectal, intravenous, intramuscular, or subcutaneous. Doses of 0.1 to 20 mg/kg/day and preferably of 0.5 to 10 mg/kg/day of active ingredient are generally adequate, and if preferred it can be administered in divided doses given two to four times daily. In the treatment of Parkinsonism, this invention also includes the coadministration of a compound of Formula I with zero or positive optical rotation with an art-recognized antiparkinsonism agent such as SINEME (Merck & Co., Inc., Rahway, N.J.), each agent being administered in a dose comparable to that recommended for use as though it were the sole therapeutic agent. The coadministration is accomplished either by administration of the two agents separately at approximately the same time or by administration of a single unit dosage form comprising the combined agents such as: 10 mg of a compound of Formula I with zero or positive optical rotation; 100 mg of l-dopa; and 10 mg of carbidopa. The coadministration is particularly useful when, as frequently happens, parkinsonism symptoms break through despite a history of successful treatment with SINEME z or other art-recognized antiparkinsonism agent. A further method of treatment, comprising another embodiment of this invention, is the treatment of depression with a compound of Formula I with zero or negative optical activity. Doses and modes of administration comparable to those described above are satisfactory for this novel method of treatment. It is to be noted that the precise unit dosage form and dosage level depend upon the requirements of the individual being treated, and consequently are left to the discretion of the therapist. EXAMPLE 1 Trans-1a,2,3,4a,5,6-hexahydro-4H-naphth[1,2-b]-1,4 oxy ine hydrochloride Step A: Preparation of 2-chloroacetamido-3,4-dihydro- naphthalen-1(2H)-one To a stirred solution of sodium bicarbonate (4.0 g) in water (50 ml) layered with ethyl acetate (200 ml) was added solid 2-amino-3,4-dihydronaphthalen-1(2H)-one hydrochloride (4.0 g, 2 mmol). After the solid had dissolved chloroacetylchloride (1.6 ml, 2 mmol) was added dropwise over 10 minutes. After stirring for I hr, the ethyl acetate layer was separated, washed with brine and dried over Na2SO4. Evaporation afforded 2.7 g (57%) of a dark solid; m.p. 118-122 C. The product was purified by chromatography on silica using ethyl acetate: hexane (1:1 v/v) to elute, m.p. 121-1230C. Step B: Preparation of trans-2-chloroacetamido 1,2,3, 4-tetrahydronaphthalen-l-ol To a solution of 2-chloroacetamido-3,4 dihydronaphthalen-l(2H)-one (2.3 g, 1 mmole) in ethanol (50 ml) and chloroform (20 ml) was added sodium borohydride (500 mg) in portions. After 1 hr, several drops of acetic acid were added to destroy excess sodium borohydride. The mixture was poured into water (150 ml) and the product was extracted into chloroform. The chloroform was separated, dried (Na2SO4) and evaporated to yield 1.7 g (71%) of a white solid m.p. 126-1300C, After recrystallization from butylchloride it had m.p. 136-1380C. Step C: Preparation of trans-la,2,4,4a,5,6-hexahydro naphth[1,2-b]-1,4-oxazin-3-one To a suspension of NaH (2.4 g, 53% mineral oil) in DMF (24 ml) was added a solution of trans-2 chloroacetamido-l, 2,3, 4-tetrahydronaphthalen-l-ol (5.5 g, 2.3 mmole). The reaction mixture was stirred at room temperature for 3 hr, some ethanol was added to destroy excess NaH and the reaction mixture was poured into water (150 ml). The resulting solid was filtered and dried to yield 3.1 g (71%) of product, m.p. 2250C (dec). After recrystallization from butyl chloride it had m.p. 232-2350C (dec). Step D: Preparation of trans-la,2,3,4a,5,6-hexahydro 4H-naphthl1,2-b]-1,4-oxazine hydrochloride To a stirred suspension of LiAlH4 (2.0 g) in THF (100 ml) was addded a solution of trans la,2,4,4a,5,6-hexahydronaphth[1,2-b]-1,4-oxazin-3- one (2.4 g, 1.2 mmole) in THF (250 ml). The reaction mixture was heated at reflux for 4 hrs, cooled in an ice bath, and ethanol was added to destroy excess LiAlH4. Rochell salt (100 ml of a 20% (w/v aqueous) solution) was added and the mixture was extracted with ethyl acetate (3 x 300 ml). The ethyl acetate layer was dried (Na2SO4) treated with decolorizing carbon, filtered, and evaporated to a red oil. The oil was dissolved in 20 ml of 1:1 (v/v) acetone-ether and several ml of methanolic hydrochloric acid was added. The resulting solid was filtered and dried to yield 2.5 g of product, m.p. 2900C (dec). EXAMPLE 2 Trans-1a,2,3,4a,5,6-hexahydro-7-methoxy-4H-naphth [1,2-b]-1,4-oxazine hydrochloride Employing the procedures substantially as described in Example 1, Steps A through D, but substituting for the starting material used therein an equimolecular amount of 2-amino-5-methoxy-3,4 dihydronaphthalen-l(2H) -one hydrochloride, there were produced in sequence: Step A: 2-chloroacetamido-5-methoxy-3,4-dihydro naphthalen-l(2H) -one, m.p. 147-1490C. Step B: trans-2-chloroacetamido-5-methoxy-l,2, 3,4- tetrahydronaphthalen-l-ol, m.p. 125-1280C. Step C: trans-la,2,4,4a,5,6-hexahydro-7-methoxy naphth[l,2-bl-1,4-oxazin-3-one, m.p. 294-2950C. Step D: trans-la,2,3,4a,5,6-hexahydro-7-methoxy-411- naphth[l,2-b] -1,4-oxazine hydrochloride, m.p. 2600C. Employing the procedure substantially as described in Example 1, Steps A through D but substituting for the starting materials used in Step A thereof an equimolecular amount of each of the substituted 2-amino-3,4-dihydronaphtalen-1(2H)-ones described in Table I and the &alpha;-R5-chloroacetyl chlorides also described in Table I there are produced the respective substituted trans-la,2,3, 4a,5,6-hexahydronaphth[l,2-b] -1,4-oxazines also described in Table I in accordance with the following reaction sequence: : EMI13.1 TABLE I R1 R2 R3 R4 R5 Cl H H H H H H Cl H H Cl Cl H H H H -C1 H H H -CH3 H H H H -CH3 -CH3 H H H H -CH3 H H H H H -CH3 H H -F H H H H -F -F H H H H -F H H H H H -F H H H -OCH3 H H H H H -OCH3 H -CH3 H H H -OCH3 H -OCH3 -OCH3 H H H H -OCH3 -OCH3 H H H -OC2H5 H H H H H -OC3H7 H -C6H5 -OC2H5 H H H -C3H7-n H H -OCH3 H -C6H5 EXAMPLE 3 Trans-la,2,3,4a,5,6-hexahydro-4-benzyl-4H-naphth- [1,2-b3-1,4-oxazine hydrochloride hemihydrate Step A: Preparation of 2-benzamido-3,4-dihydro naphthalen-1(2H)-one A solution of N-benzoyl homophenylalanine (4.4 g, 1.66 mmole) in acetic anhydride (60 ml) was heated on the steam bath for 1/2 hr. The solvent was removed in vacuo, the resulting oil was dissolved in CS2 and then added to a suspension of AlCl3 (6.2 g, 4.6 mmoles) in CS2 (60 ml). This mixture was heated at reflux for 1 hr, the solvent was removed in vacuo and ice was added to the residue. The reaction mixture was extracted with ethyl acetate, the ethyl acetate layer was washed with brine, dried over Na2SO4 and evaporated to dryness to afford 3.6 g (88%) of product, m.p. 1750C. After recrystallization from toluene it had m.p. 175-1780C. Step B: Preparation of trans-2-benzylamino-l,2,3,4- tetrahydronaphthalen-l-ol A solution of 2-benzamido-3,4-dihydro naphthalen-1(2H)-one (3.0 g, 1.1 mmole) in THF (150 ml) was added dropwise to a suspension of LiAlH4 (2.0 g) in THF (50 ml). The reaction was heated at reflux for 2 hr and then cooled to room temperature. Enough ethanol was added to destroy excess LiAlH4 followed by 150 ml of Rochell's salt solution (20%). The resulting mixture was extracted with ethyl acetate, the ethyl acetate layer was washed with brine and dried over Na2SO4. Evaporation of the solvent afforded 2.5 g (88%) of the product, m.p. 110-l140C. After recrystallization from cyclohexane it had m.p. 112-1150C. Step C: Preparation of trans-la,2,4,4a,5,6-hexahydro 4-benzylnaphth[1,2-b]-1,4-oxazin-3-one A bicarbonate solution (2.0 g in 75 ml of H20) was layered with an ethyl acetate solution (100 ml) containing trans-2-benzylamino-l,2,3,4- tetrahydronaphthalen-l-ol (2.0 g, 0.8 mmole), and the whole was stirred rapidly while chloroacetyl chloride (0.89 g, 0.8 mmole) was added dropwise. After 0.5 hr the ethyl acetate layer was separated, dried over Na2SO4 and evaporated. The resulting light purple solid was dissolved in DMF (10 ml) and added to a suspension of NaH (0.5 g of 53% mineral oil) in DMF (15 ml). After 1 hr the reaction mixture was poured into water (150 ml). The solid that separated was filtered and dried to yield 1.8 g (78%) of product, m.p. 1850C. After recrystallization from butyl chloride it had m.p. 185-187 C. Step D: Preparation of trans-1a,2,3,4a,5,6-hexahydro 4-benzyl-4H-naphth [1,2-b] -1,4-oxazine hydrochloride hemihydrate This reaction was carried out substantially as described in Example 1, Step D using trans1a,2,4a,5,6-hexahydro-4-benzylnaphth[1,2-b]-1,4 oxazin-3-one as the starting material. There was obtained a 64% yield of product, m.p. 262-2650C (dec.). EXAMPLE 4 trans-la,2,3,4a,5,6-hexahydro-4-allyl-4H-naphth[1,2-b]- 1,4 -oxaz ine hydrochloride To a solution of trans-la,2,3,4a,5,6 hexahydro-4H-naphth[l,2-b]-l,4-oxazine (1.0 g, 0.52 mmole) (Example 1, Step D) in DMF (15 ml) was added K2CO3 (1.1 g) and allyl bromide (0.95 g, 0.79 mmoles). The reaction mixture was stirred at room temperature for 6 hrs, and then concentrated in vacuo to a small volume. The reaction was diluted with water (40 ml) and extracted with ether (3 x 100 ml). The ether layer was washed with brine, dried over Na2SO4 and filtered. Ethanolic hydrochloric acid was added and the salt separated to give 0.77 g (55%) of product, m.p. 187-1920C. Employing the procedure substantially as described in Example 4 but substituting for the naphthoxazine and allyl bromide used therein, equimolecular amounts of the naphthoxazines and alkyl halides (R-X) described in Table II, there were produced the N-alkyl-naphthoxazines, also described in Table II in accordance with the following reaction: EMI17.1 TABLE II HC1 salt X R R1- R2 R3 R4¯ m.p. ( C) Br n-C3H7- H H H H 259-261 Br C2H5- -OCH3 H H H 279-284 Br CH2=CHCH2- -OCH3 H H H 245-246 Similarly prepared are the compounds described in Table III. TABLE III R R1 R2 R3 R4 R5 CH3 - H H H H H CH3- -OCH3 H H H H C6H5CH2- H H H H H C6H5CH2- -OCH3 H H H H C2H5- -C1 H H H H C2H5- Cl -Cl H H H H C2H5- H -CH3 H H H C2H5- H H -CH3 H -CH3 C2H5- -F -F H H H C3H7 -OCH3 H H H H C3H7 H H OCH3 H H C2H5- H -OCH3 H H H C2H5- H H H -OCH3 H 03117 -OCH3 -OCH3 H H H C3H7 H OCH3 -OCH3 H H i-C3H7- H H H -OCH3 H C2H5- H H -OCH3 H -C H EXAMPLE 5 trans-la,2,3, 4a, 5, 6-Hexahydro-4-ethyl-9-methoxy- 4H-naphth[1,2-bl-1,4-oxazine hydrochloride Step A: Preparation of 7-methoxy-2-oximino-3,4 dihydronaphthalen-1(2H)-one A mixture of potassium tert-butoxide (11.5 gm, 0.1 m), ether (400 ml), tert-butanol (15 ml) and absolute ethanol (15 ml) was refluxed for 1/2 hour to insure complete solution of the potassium tertbutoxide. To the hot solution was added 7-methoxy-ltetralone (17.6 gms, 0.1 m) and the reaction mixture turned from yellow to dark brown. To this refluxing solution was added isopentyl nitrite (19 ml). During this addition external heating was not necessary because of the exothermic nature of the reaction. The reacton mixture was refluxed for 1/2 hour during which time the walls of the flask became coated with a brown solid. After cooling in an ice-bath, the solvent was removed by decantation. To the solid was added aqueous hydrogen chloride (1N, 200 ml). After stirring 1/2 hour, the brown solid was filtered to yield 10 gms (50%) of product. Step B: Preparation of 2-Acetamido-7-methoxy-3,4 dihydronaphthalen-l(2H)-one A mixture of 2-oximino-7-methoxy-3,4-dihydro naphthalen-1(2H)-one (8.7 gm, 0.04 m), palladium on carbon (10%, 1 gm) tetrahydrofuran (150 ml) and acetic anhydride (25 ml) was hydrogenated on a Parr apparatus for 3 hours. The catalyst was filtered, and the solvents were removed under reduced pressure to yield the product as an oil, which was used in the next step without further purification. Step C: Preparation of trans-2-Acetamido-7-methoxy 1,2,3,4-, -tetrahydronaphthalen-l-ol To a stirred solution of 2-acetamido-7methoxy-3,4-dihydronaphthalen-1(2H)-one in absolute ethanol (100 ml) was added sodium borohydride (1.6 gms, 0.04 m) in portions. After stirring for 1/2 hour, acetic acid was added to decompose any excess sodium borohydride. The reaction mixture was poured onto water (150 ml) and this was extracted with ethyl acetate (3 x 150). The ethyl acetate was washed with aqueous saturated sodium chloride, and was dried over anhydrous sodium sulfate. After filtration, the ethyl acetate was removed under reduced pressure (20 mm) to give a semisolid. The solid was slurried with ether and filtered to yield 3.3 gms (35*) of product as a white solid, m.p. 1350-1400C. Step: Preparaton of trans-la,2,4,4a,5,6 hexahydro-4-ethyl-9-methoxynaphth[1,2-b]- 1,4-oxazin-3-one To a suspension of lithium aluminum hydride (2.8 gms, 0.07 m) in tetrahydrofuran (30 ml) at 0-50C was added a slurry of trans-2-acetamido-7-methoxy l,2,3,4-tetrahydronaphthalen-1-ol (2.16 gms, 0.009 m) in tetrahydrofuran (12 ml) and ethylene glycol dimethyl ether (8 ml). During the addition the internal temperature was kept below IOOC. After the addition was completed, the reaction mixture was refluxed for 1/2 hour. The reaction was cooled to 5-100C, and the excess lithium aluminum hydride was hydrolyzed with isopropanol (4.8 ml) and saturated aqueous sodium sulfate (2.4 ml). After the addition of methylene chloride (50 ml), the inorganic salts were removed by filtration through filter cell. The solvent was removed under reduced pressure (20 mm) and the tan solid was disssolved in ethyl acetate (60 ml). To the stirred ethyl acetate solution was added water (90 ml) with sodium carbonate (9 gms) dissolved in it. To the biphasic mixture was added chloroacetyl chloride (1.5 ml) dropwise. The organic layer was separated and was washed with saturated aqueous sodium chloride. After drying over anhydrous sodium sulfate and filtration, the solvent was removed under reduced pressure (20 mm). The oil was dissolved in acetonitrile (7.5 m) and tetrahydrofuran (7.5 ml) and it was added to an ice cold (0-50C) suspension of sodium hydride (0.75 gm, 50%) in tetrahydrofuran (20 ml). The excess sodium hyride was destroyed by addition of absolute ethanol, and the reaction mixture was poured onto water (100 ml). This was extracted with ethyl acetate, and the extract was washed with saturated aqueous sodium chloride. After drying over anhydrous sodium sulfate and filtration, the solvent was removed under reduced pressure (20 mm) to give 1.8 g (77%) of product. Step E: Preparation of trans-la,2,3,4a,5,6 hexahydro-4-ethyl-9-methoxy-4H-naphth [1,2-b] - 1,4-oxazine hydrochloride To a slurry of lithium aluminum hydride (1.0 gms, 0.02 m) in tetrahydrofuran (20 ml) at 0-50C was added trans-la,2,4,4a,5,6-hexahydro-4-ethyl-9methoxynaphth[l,2-b]-1,4-oxazin-3-one (1.8 gms, 0.007 m) in tetrahydrofuran (36 ml) and ethylene glycol dimethyl ether (24 ml). Upon completion of the addition, the reaction mixture was refluxed for 1/2 hour. After cooling to 0-50C, the excess lithium aluminum hydride was hydrolyzed with isopropanol (4.8 ml) and saturated aqueous sodium sulfate (3 ml). After addition of methylene chloride (50 ml), the inorganic salts were collected by filtration through filter cell. The solvents were dried over anhydrous sodium sulfate. After filtration, the organic solvents were removed under reduced pressure (20 mm) to give an oil. The oil was dissolved in ether (50 ml) and ethanolic hydrogen chloride (2.0 ml, 7.2 N) was added. After decantation of the solvent, the solid was recrystallized from methanol to yield 500 mg of product, m.p. 273-275"C. Employing the procedure substantially as described in Example 5, Steps A through E, but substituting for the starting material used therein, an equimolecular amount of a-tetralone, 6-methoxy-l-tetralone, 5,6-dimethoxy-l-tetralone, 8-benzyloxy-l-tetralone, 6-benzyloxy-l-tetralone, and 6,7-dimethoxy-l-tetralone, there were produced, respectively: trans-la,2,3,4a,5,6-hexahydro-4-ethyl-4H-naphth[1,2-b]- 1,4-oxazine hydrochloride, m.p. 218-2210C (dec.); and trans-la,2,3,4a,5,6-hexahydro-4-ethyl-8-methoxy- 4H-naphth[1,2-b]-1,4-oxazine hydrochloride, m.p. 210-213 0C. trans-la,2,3,4a,5,6-hexahydro-4-ethyl-7,8-di- methoxy-4H-naphth[l,2-b]-1,4-oxazine hydrochloride, m.p. 184-1850C. trans-1a,2,3,4a,5,6-hexahydro-10-benzyloxy-4-ethyl 4H-naphth[1,2-b]-1,4-oxazine, (oil); trans-1a,2,3,4a,5,6-hexahydro-8-benzyloxy-4-ethyl-4H naphth[1,2-b]-1,4-oxazine, (oil); and trans-la,2,3,4a,5,6-hexahydro-8,9-dimethoxy-4-ethyl-4H- naphth[l,2-b]-1,4-oxazine hydrochloride, m.p. 287-2890C. (dec.). Employing the procedure substantially as described in Example 5, Steps A through E but substituting for the acetic anhydride used in Step B thereof an approximately equimolar amount of propionic anhydride, there was produced in sequence: 2-propionamido-7-methoxy-3,4-dihydro-l (211) -naphtha- lenone; trans-2-propionamido-7-methoxy-1,2,3,4-tetrahydro-1- naphthalenol; trans-1a,2,3,4a,5,6-hexahydro-9-methoxy-4-propylnaphth [1,2-b]-1,4-oxazine-3-one; and trans-1a,2,3,4a,5,6-hexahydro-9-methoxy-4-propyl-4H naphth[l,2-b]-1,4-oxazine hydrochloride, m.p. 237-2410C. Similarly, from: 6-benzyloxy-7-methoxy-l-tetralone; 6-methoxy-7-benzyloxy-l-tetralone; and 6,7-dibenzyloxy-l-tetralone there are produced, respectively, trans-1a,2,3,4a,5,6-hexahydro-8-benzyloxy-9-methoxy-4 propyl-4H-naphth[1,2-b]-1,4-oxazine hydrochloride, trans-1a,2,3,4a,5,6-hexahydro-8-methoxy-9-benzyloxy-4 propyl-4H-naphth[1,2-b] -1,4-oxazine hydrochloride; and trans-la,2,3,4a,5,6-hexahydro-8,9-dibenzyloxy-4-propyl- 4H-naphth[1,2-b]-1,4-oxazine hydrochloride. Similarly, using benzoic anhydride there are prepared in sequence: trans-2-benzamido-7-methoxy-1,2,3,4-tetrahydro-1- naphthalenol; trans-la,2, 3, 4a, 5, 6-hexahydro-9-methoxy-4-benzylnaphth- [1,2-b] -l,4-oxazine-3-one; and trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4-benzyl-4H- naphth[l,2-b]-1,4-oxazine hydrochloride. EXAMPLE 6 (+)- and (-)- trans-la,2,3,4a,5,6-Hexahydro4-ethyl-4H-naphth[1,2-b]-1,4-oxazine hydrochloride Step A: Preparation of 2-Acetamido-3,4-dihydro naphthalen-1(2H)-one A slurry of 2-oximino-3,4dihydro- naphthalen-1(2H)-one (8.75 gm, 0.05 m) acetic anhydride (25 ml), tetrahydrofuran (150 ml) and Pd/C (10%, 500 mg) was hydrogenated on a Parr apparatus for 3 hours. The catalyst was removed by filtration through diatomaceous earth. The organic solvents were evaporated under reduced pressure (20 mm) to yield the product as an oil, which was used in the next step without further purification. Alternatively: To a stirred biphasic mixture of aqueous sodium bicarbonate (10 gm in 100 ml) and methylene chloride (250 ml) was added 3,4-dihydro-2-aminonaphthalen-1(2H)-one hydrochloride (8.3 gms, 0.04 m). When solution was achieved, acetylchloride (3.9 gms, 0.05 m) was added dropwise. The reacton was stirred for 1 hour. The organic layer was separated, washed with saturated aqueous sodium chloride solution, and dried over anhydrous sodium sulfate. After filtration of the inorganics, the solvent was removed under reduced pressure (20 mm) to give the product as a dark semisolid which was used in the next step without purification. Step B: Preparation of trans-2-Acetamido-l,2,3,4 tetrahydronaphthalen-1-ol To a solution of the 2-acetamido-3,4-dihydronaphthalen-1(2H)-one from Step A in absolute ethanol (150 ml) was added sodium borohydride (2.0 gms, 0.05 m) in portions. The reaction mixture was stirred at room temperature for 1/2 hour. Acetic acid was added dropwise to destroy the excess sodium borohydride. The reaction mixture was poured into water and extracted with ethyl acetate (3 x 150 ml). The ethyl acetate was washed with saturated aqueous sodium chloride (150 ml) and dried over anhydrous sodium sulfate. After filtration the solvent was removed under reduced pressure to yield 5.5 gms (54%, over Steps A and B), of product as a solid. Step C: Resolution of trans-2-Acetamido-l,2,3,4 tetrahydronaphthalen-l-ol via l-a-methoxy mandelic acid esters Step 1: Ester Formation and Separation To a stirred mixture of trans-2-acetamido 1,2,3,4-tetrahydronaphthalen-l-ol (1.0 gm, 0.0049 m), N,N'-dicyclohexylcarbodiimide (1.7 gms, 0.0083 m) and l-a-methoxymandelic acid (1.5 gm, 0.009 m) in methylene chloride (125 ml) was added 4-dimethylaminopyridine (0.2 gm). After filtration of the solid formed, the methylene chloride solution was flash chromatographed to give 450 mg of "top ester" and 400 mg of "bottom ester"; 52% and 45% yield respectively. Step 2: Saponification to yield (+)-trans-2 acetamido-1,2,3,4-tetrahydronaphthal- en-l-ol and (-)trans-2-acetamido- 1,2,3,4-tetrahydronaphthalen-l-ol To a solution of potassium hydroxide (0.52 gm, 0.009 m) in absolute ethanol (20 ml) was added the "top ester" (2.1 gm, 0.005 m) and water (10 drops). The mixture was heated in a hot water bath at 500C until solution was achieved (10 mins). The reaction mixture was poured into water, and the solid (160 mg) was filtered. The aqueous layer was extracted with chloroform (3 x 150 ml). The chloroform was dried over anhydrous sodium sulfate. After filtration, the chloroform was removed under reduced pressure (20 mm) to give a purple solid. The solid was suspended in ether and filtered to yield 0.95 gms (78%) of product as a white solid with a rotation of ta]D25 = +49.80 (C, 0.996 in ethanol) To a solution of potassium hydroxide (0.39 gm, 0.007 m) in absolute ethanol (20 ml) was added the "bottom ester" (1.6 gm, 0.0045 m) and water (10 drops). The mixture was heated in a hot water bath at 500C until solution was achieved (10 mins). The reaction mixture was poured into water and it was extracted with chloroform. The chloroform was dried over anhydrous sodium sulfate. After filtration, the chloroform was removed under reduced pressure (20 mm) to yield 0.7845 gms (85%) of product as a white solid; (a] 25 = -41.60 (C, 0.0994 in ethanol). D Step D: Preparation of (+)- and (-)-trans-la,2, 4,4a,5,6-Hexahydro-4-ethylnaphth[1,2-b] - I,4-oxazin-3-one To a suspension of lithium aluminum hydride (0.72 gm, 0.0189 m) in tetrahydrofuran (10 ml) at OOC was added a suspension of (+) -trans-2-acetamido- 1,2,3,4-tetrahydronaphthalen-l-ol (0.7 gms, 0.0034 m) in tetrahydrofuran (12 ml) and ethylene glycol dimethyl ether (8 ml). During the addition the internal temperature was kept below 100C. After the addition was completed, the reaction mixture was heated to reflux for 1/2 hour. After cooling the reaction to 5-l00C, the excess lithium aluminum hydride was hydrolyzed with isopropanol (1.6 ml) and saturated aqueous sodium sulfate (0.8 ml). After addition of methylene chloride (50 ml), the inorganic salts were removed under reduced pressure, and the oil was dissolved in ethyl acetate (20 ml). To the stirred ethyl acetate solution was added water (20 ml) with sodium carbonate (3.04 g) dissolved in it. To the biphasic mixture was added chloroacetyl chloride (0.48 ml). The organic layer was separated and washed with saturated aqueous sodium chloride. The ethyl acetate was dried over anhydrous sodium sulfate. After filtration, the ethyl acetate was removed under reduced pressure (20 mm) to give an oil. The oil was dissolved in acetonitrile (2.5 ml) and tetrahydrofuran (2.5 ml). This solution was added to a suspension of sodium hydride (0.24 gm, 50%) in tetrahydrofuran (10 ml) at 0-50C. After the addition was completed, the excess sodium hydride was destroyed by adding absolute ethanol. The reaction mixture was poured into water and was extracted with ethyl acetate. After the ethyl acetate was washed with saturated aqueous sodium chloride, it was dried over anhydrous sodium sulfate. After filtration, the ethyl acetate was removed under reduced pressure (20 mm) to yield an oil which crystallized to give 550 mg (70%) of (+)-product, m.p. 1040-1060C. The (-)isomer was produced in the same manner using the same reaction conditions to give 450 mg (56%) of (-)-product, m.p. 970-l000C. Step E: Preparation of (+)- and (-)-trans la, 2,3,4a,5, 6-hexahydro-4-ethyl-4H-naphth- [1,2-b] -1,4-oxazine hydrochloride To a suspension of lithium aluminum hydride (0.5 gm, 0.01 m) in tetrahydrofuran (10 ml) at 0-50C was added (+) -trans-la,2,4,4a,5,6-hexahydro- 4-ethyl-naphth[l,2-b]-1,4-oxazin-3-one (0.55 gm, 0.0024 m) in tetrahydrofuran (12 ml) and ethylene glycol dimethylether (8 ml). Upon completion of the addition, the reaction mixture was refluxed for 1/2 hour. The reaction mixture was cooled to 0-50C and the excess lithium aluminum hydride was hydrolyzed with isopropanol (1.6 ml) and saturated aqueous sodium sulfate (0.8 ml). After addition of methylene chloride (50 ml), the inorganic salts were removed by filtration through filter cell. The solution was dried by anhydrous sodium sulfate. After filtration, the organic solvents were removed under reduced pressure (20 min) to give an oil. The oil was dissolved in ether (100 ml) and ethanolic hydrogen chloride (1.5 ml, 7.2 N) was added. The precipitated solid was recrystallized from methanol to give 149 mg (25%) of (+)-product. m.p. 233-237 C, [&alpha;]D25 = +56.560 (C, 0.944 in ethanol). (-) -trans-la,2,3,4a,5,6-Hexahydro-4-ethyl- 4H-naphth-[1,2-b]-1,4-oxazine hydrochloride was produced in a similar manner using lithium aluminum hydride (0.35 gm, 0.009 m) and (-)-trans-la,2, 3,4a,5,6-hexahydro-4-ethylnaphthE1,2-bl-1,4-oxazin-3- one (0.45 gm, 0.002 m) to give 130 mg (26%) of 25 (-)-product; m.p. 230-2340C, [a] D = 57.100 (C, 0.904 in ethanol). EXAMPLE 7 (+) -trans-la,2,3,4a,5,6-Hexahydro-9-Methoxy-4-Propyl- 4H-Naphth[1,2-bl-1,4-oxazine hydrochloride Step A. Esterification of trans-2-propionamido 7-methoxy-l,2,3, 4-tetrahydro-l-naphthalenol with l-a-methoxymandelic acid and separation of the diastereomeric esters. A mixture of equal molar quantities of trans-2-propionamido-7-methoxy-I,2,3,4-tetrahydro-1- naphthalenol, N,N'-dicyclohexylcarbodiimide, and -a-methoxymandelic acid in methylene chloride, containing a catalytic amount of 4-dimethylaminopyridine was stirred at room temperature for 1 hour. The reaction mixture was filtered and subjected to medium pressure chromatography over silica gel. By collecting the proper fractions there were obtained the pure (+) and (-) enantiomeric esters. Step B. Preparation of (+)-trans-2-propionamido-7 methoxy-1 , 2,3, 4-tetrahydro-1-naphthalenol. Material obtained from one of the pure fractions obtained in Step A was dissolved in a solution of potassium hydroxide (slight molar excess) in ethanol and heated at reflux for 10 minutes. The cooled reaction mixture was poured into water, neutralized with dilute hydrochloric acid and the resulting solid was recovered by filtration. Recrystallization from ethyl acetate afforded the subject compound, m.p. 162-1630C [a]D + 71.02 (C 0.105 EtOH). Anal. Calc. for C14HlgNO3: C, 67.44; 11, 7.68; N, 5.61. Found: C, 67.73; H, 7.93; N, 5.55. Step C. Preparation of (-)-trans-la,2,4,4a,5,6-hexa hydro-9-methoxy-4-propylnaphth[1,2-b]-1,4- oxazin-3-one Using essentially the procedure described in Example 6, Step D but employing the product from Step B above as starting material the subject compound was obtained as a solid, 94-960C, [a]D -36.94 (C, 0.0896, EtOH). Anal. calcd. for C16H2lNO3: C, 69.79; H, 7.69; N, 5.09. Found: C, 69.88; H, 8.02, N, 4.96. Step D: Preparation of (+)-trans-1a,2,3,4a,5,6 hexahydro-9-methoxy-4-propyl-4H-naphth- [1,2-b] -1,4-oxazine hydrochloride Using essentially the same procedure as described in Example 6, Step E but employing the product from Step C above as starting material, the subject compound was obtained as a solid m.p. 231-2330C, [a]D +47.28 (C 0.105, EtOH). Anal. Calcd. for C16H23NO2.HCl: C, 64.52; H, 8.12; N, 4.70. Found: C, 64.24; H, 8.23; N, 4.64. Employing the procedure substantially as described in Example 7, Steps B, C and D but employing as starting material the other diastereomeric ester obtained in Step A of Example 7, there was obtained in sequence: (-) -trans-2-propionamido-7-methoxy-1,2,3,4-tetrahydro- l-naphthalenol; (+) -trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4-propyl- naphth[l,2-b]-1,4-oxazin-3-one; and (-)-trans-1a,2,3,4a,5,6-hexahydro-9-methoxy-4-propyl4H-naphth[1,2-b]-1,4-oxazine hydrochloride, m.p. 231-2330C, [a]D -47.44 (0.0978, EtOH). Anal. Calcd. for C16H23NO2.HCl: C, 64.52; H, 8.12; N, 4.70. Found: C, 64.68; H, 8.37; N, 4.66. EXAMPLE 8 (+) -trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4-ethyl-4H- Naphth[1,2-b]-1,4-oxazine hydrochloride Employing the procedures substantially as described in Example 7, Step A, but substituting for the propionamido compound used therein, an equimolar amount of the acetamido homolog, there were obtained the separated, pure diastereomeric esters. Taking one of the foregoing esters through the procedures as described in Example 7, Steps B, C and D there were produced in sequence: (+) -trans-2-acetamido-7-methoxy-l,2,3,4-tetrahydro-1- naphthalenol; trans-1a,2,3,4a,5,6-hexahydro-9-methoxy-4-ethylnaphth [1,2-b]-1,4-oxazin-3-one; and (+)-trans-1a,2,3,4a,5,6-hexahydro-9-methoxy-4-ethyl-4Hnaphth[l,2-b]-1,4-oxazine hydrochloride, m.p. 286-2880C (dec.). Anal. Calcd. for C15H2lNO2HCl: C, 63.48; H, 7.82; N, 4.94. Found: C, 63.08; H, 8.05; N, 5.01. From the other diastereomeric ester of Example 8, using the procedures described in Example 7, Steps B, C and D, there were obtained in sequence: (-)-trans-2-acetamido-7-methoxy-1,2,3,4-tetrahydro-1napthalenol; (-) -trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4-ethyl- naphth[l,2-b]-1,4-oxazin-3-one; and (-) -trans-la,2, 3,4a,5,6-hexahydro-9-methoxy-4-ethyl-411- naphthE1,2-bJ-1,4-oxazine hydrochloride, 282-2830C (dec.) Anal. Calcd. for C15H2lNO2.HCl: C, 63.48; 11, 7.82; N, 4.94. Found: C, 63.22; H, 8.06; N, 4.91. Employing the procedures used in Example 6, 7 and 8, the other novel trans compounds of this invention are produced as optically pure products, such as (+) and (-) -trans-la,2,3,4a,5,6-hexahydro-9- methoxy-4-benzyl-4H-naphth[1,2-b]-1,4-oxazine hydrochloride. EXAMPLE 9 trans-1a,2,3,4a,5,6-hexahydro-7-hydroxy-4-ethyl4H-naphth[1,2-b]-1,4-oxazine hydrochloride An intimate mixture of pyridine hydrochloride (312 mg, 0.27 mmole) and trans-la,2,3,4a,5,6- hexahydro-4-ethyl-7-methoxy-4H-naphth[1,2-b]-1,4- oxazine hydrochloride (250 mg, 0.09 mmole) was heated at 2000C for 5 hours. The cooled reaction mixture was made slightly basic with NH4OH and then extracted with chloroform (3 x 50 ml). The organic phase was washed with brine, dried over MgSO4, and then concentrated to dryness in vacuo. The resulting solid was dissolved in ethyl acetate and some 4N ethanolic hydrochloric acid was added which caused the precipitation of the product. The yield was 60 mg (25%), m.p. 294-2970C (dec.) (isopropanol) Similarly, but omitting the treatment with ethanolic hydrogen chloride, there were prepared from the corresponding methoxy compounds: trans-la,2,3, 4a, 5, 6-hexahydro-4-ethyl-9-hydroxy-4H- naphth[l,2-b]-1,4-oxazine, m.p. 223-2250C; trans-la,2,3,4a,5,6-hexahydro-4-propyl-9-hydroxy-4H- naphth[l,2-b]-1,4-oxazine, m.p. 164-1660C; (+) -trans-la,2,3,4a,5,6-hexahydro-4-ethyl-9-hydroxy-4H- naphth[l,2-b]-1,4-oxazine, m.p. 165-1680C, [a]D + 51.77, (C, 0.101, EtOH); (-) -trans-la,2,3,4a,5,6-hexahydro-4-ethyl-9-hydroxy-4H- naphth[1,2-b]-1,4-oxazine, m.p. 164-166 C, [&alpha;]D-45.45, (C, 0.101, EtOH) ; ; (+) -trans-la,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl- 4H-naphth[1,2-b]-1,4-oxazine, m.p. 158-1600C, [a]D+59.54, (C, 0.0964, EtOH) ; and (-) -trans-la,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl- 4H-naphth[1,2-b] -1,4-oxazine, m.p. 158-1610C, [a]D-62.63, (C, 0.0942, EtOH) Employing the procedure substantially as described in Example 9, but substituting for the trans-1a,2,3,4a,5,6-hexahydro-4-ethyl-7-methoxy4H-naphth[1,2-b]-1,4-oxazine hydrochloride used as starting material therein, an equimolar amount of the alkoxynaphthoxazines described in Table IV, there are produced the corresponding hydroxynaphthoxazines, also described in Table IV in accordance with the following reaction: : EMI34.1 Table IV STARTING MATERIALS PRODUCTS N 7 8 9 10 7 8 9 10 R5 CH2=CHCH2- -OCH3 H H H -OH H H H H CH3- -OCH3 H H H -OH H H H H C6H5CH2- -OCH3 H H H -OH H H H H C3H7- -OCH3 H H H -OH H H H H C3H7- H H -OCH3 H H H -OH H -CH3 C2H5- H H -OCH3 H H H -OH H -C6H5 i-C3H7- H H H -OCH3 H H H -OH H H H H -OCH3 H H H -OH H H H H H H -OCH3 H H H -OH H H -OCH3 H H H -OH H H H H H H H -OC3H7 H H H -OH H H H -OC2H5 H H H -OH H H H H EXAMPLE 10 trans-1a,2,3,4a,5,6-hexahydro-10-hydroxy-4-ethyl-4Hnaphth[1,2-b]-oxazine hydrochloride The lG-benzyloxy material from Example 5 was dissolved in C2H5OH:THF (1:1 v/v), 10% palladium on carbon catalyst was added and the reaction mixture was hydrogenated on a Parr apparatus at 25 psi until hydrogen uptake ceased. The reaction mixture was removed from the Parr, filtered, and the solvent was removed in vacuo. The residue was purified by medium pressure chromatography using CHC13.CH30H (9:1 v/v) to elute. The subject compound was obtained as a white solid (hydrogen chloride gas added to an ethanol solution), m.p. 262-2650C (dec.). Employing the procedure substantially as described in Example 10, but starting with the 8-benzyloxy compound, also from Example 5, there was produced trans-la,2,3,4a,5,6-hexahydro-8-hydroxy- 4-ethyl-4H-naphthtl,2-b]-1,4-oxazine, m.p. 187-1910C. Employing the procedure substantially as described in Example 10 but starting with trans-1a,2,3,4a,5,6-hexahydro-8-benzyloxy-9-methoxy-4 propyl-4H-naphth[1,2-b]-1,4-oxazine hydrochloride; trans-1a,2,3,4a,5,6-hexahydro-8-methoxy-9-benzyloxy-4propyl-4H-naphth[1,2-bl-1,4-oxazine hydrochloride; and trans-la,2,3, 4a,5, 6-hexahydro-8, 9-dibenzyloxy-4-propyl- 4H-naphth[1,2-b]-1,4-oxazine hydrochloride; there are produced respectively: trans-1a,2,3,4a,5,6-hexahydro-8-hydroxy-9-methoxy-4 propyl-4H-naphth [1,2-b] -1,4-oxazine hydrochloride; trans-1a,2,3,4a,5,6-hexahydro-8-methoxy-9-hydroxy-4 propyl-4H-naphth[l,2-bl-1,4-oxazine hydrochloride; and trans-1a,2,3,4a,5,6-hexahydro-8,9-dihydroxy-4-propyl 4H-naphth [1,2-b] -1, 4-oxazine hydrochloride. Employing the procedure substantially as described in Example 10 but starting with the (+) or (-) -trans-1a,2,3,4a,5,6-hexahydro-9-methoxy-4-benzyl- 4H-naphth[1,2-b]-1,4-oxazine from Example 8 there are produced: (+) -trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4H-naphth- [1,2-b3-1,4-oxazine hydrochloride; and (-) -trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4H-naphth- [1,2-b]-1,4-oxazine hydrochloride, respectively. EXAMPLE 11 trans-1a,2,3,4a,5,6-hexahydro-9-acetoxy-4-propyl-4H naphth[l,2-b] -1,4-oxazine hydrochloride. A mixture of trans-la,2,3,4a,5,6-hexahydro9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine (0 7 g., 2.8 mmole), acetic anhydride (6 ml) and 4-dimethylaminopyridine (10 mg) was stirred and heated at 85-900C for 1 hour. Most of the solvent was removed in vacuo and the residue was taken up in ethyl acetate (25 ml). Addition of ethanolic hydrogen chloride afforded the subject compound in 54% yield, m.p. 218-2200 (CH3CN). Anal. calcd. for C17H23NO3. HCl: C, 62.66; H, 7.42; N, 4.30. Found: C, 62.25; H, 7.56; N, 4.40. EXAMPLE 12 trans-1a,2,3,4a,5,6-hexahydro-9-pivaloyloxy-4-propyl-4-propyl4H-naphth[1,2-b]-1,4-oxazine hydrochloride. This compound was prepared by essentially the same procedure described in Example 11 by substituting trimethylacetic anhydride for the acetic anhydride used in that example. The yield was 80%; m.p. 248-2500. Anal. Calcd. for C20H29NO3.11C1: C, 65.29; H, 8.22; N, 3.81. Found: C, 65.18; H, 8.57; N, 3.66. EXAMPLE 13 Preparation of trans-la,2,3,4a,5,6-hexahydro-9 dimethylcarbamyloxy-4-propyl-4H-naphth[1,2-b3-1,4- oxazine maleate To a cooled (100), stirred, suspension of NaH (0.2 g., 0.004 m) in THF (10 ml) was added a solution of trans-la,2,3,4a,5,6-hexahydro-9-hydroxy- 4-propyl-4H-naphth E1, 2-b]-1,4-oxazine (1.0 g. r 0.004 m) in THF (25 ml) over a period of 15 minutes. The reaction mixture was stirred one hour at 10-150 and then dimethylcarbamyl chloride (0.43 g., 0.004 m) was added. The reaction was stirred at room temperature for 18 hours, 250 ml of water were added and the solution was extracted with ethyl acetate (2 x 75 ml) The ethyl acetate extracts were dried over Na2SO4 and then concentrated in vacuo. The resulting oil was dissolved in ether and treated with an equivalent quantity of maleic acid in isopropanol. The resulting solid was recrystallized from ethyl acetate to afford the subject compound, melting point 140-1420C. Employing the procedures substantially as described in Examples 11, 12 and 13 but substituting for the acid anhydrides, carbamyl chloride and the hydroxy-naphthoxazines used therein, comparable amounts of the anhydride of formula (R7CO)2O or carbamyl chloride of formula R7COC1 and the hydroxynaphthoxazines identified in Table V, there are produced the acyloxynaphthoxazines also described in Table V, in accordance with the following reaction scheme: : EMI39.1 Table V EMI40.1 <SEP> STARTING <SEP> COMPOUND <SEP> FINAL <SEP> PRODUCT <tb> Isomer <SEP> R <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> R5 <tb> (#)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH3 <tb> (+)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH3 <tb> (-)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH3 <tb> (+)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OC-CH3 <tb> (-)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OC-CH3 <tb> (#)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCC(CH3)3 <tb> (-)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCC(CH3)3 <tb> (+)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCC(CH3)3 <tb> (-)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCC(CH3)3 <tb> (#)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH2C6H5 <tb> (+)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH2C6H5 <tb> (-)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH2C6H5 <tb> (#)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH2C6H5 <tb> EMI41.1 <SEP> STARTING <SEP> COMPOUND <SEP> FINAL <SEP> PRODUCT <tb> Isomer <SEP> R <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> R5 <tb> (+)-trans <SEP> -C3H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH2C6H5 <tb> (-)-trans <SEP> -C3H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH2C6H5 <tb> (#)-trans <SEP> -C2H5 <SEP> OH <SEP> H <SEP> H <SEP> H <SEP> O <SEP> H <SEP> H <SEP> H <SEP> H <tb> <SEP> # <tb> <SEP> -OCCH3 <SEP> O <tb> <SEP> # <tb> <SEP> -OCH2C6H5 <tb> <SEP> O <tb> (+)-trans <SEP> -C2H5 <SEP> H <SEP> -OH <SEP> H <SEP> OH <SEP> H <SEP> # <SEP> H <SEP> H <SEP> H <tb> <SEP> -OCC6H5 <tb> <SEP> O <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H5 <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCC6H5 <SEP> H <SEP> H <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -CH2CH-CH2 <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCC6H11 <SEP> H <SEP> H <SEP> H <SEP> H <tb> <SEP> O <SEP> Cl <tb> <SEP> # <SEP> # <tb> (#)-trans <SEP> -CH3 <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OC-#-Cl <SEP> H <SEP> H <SEP> H <SEP> H <tb> <SEP> O <SEP> OCH3 <tb> <SEP> # <SEP> # <tb> (#)-trans <SEP> -CH2C6H5 <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OC-#-OCH3 <SEP> H <SEP> H <SEP> H <SEP> H <tb> <SEP> O <SEP> CH3 <tb> <SEP> # <SEP> # <tb> (#)-trans <SEP> -C3H7 <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OC-#-CH3 <SEP> H <SEP> H <SEP> H <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C3H7-i <SEP> H <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCCH2 <SEP> H <tb> EMI42.1 STARTING <SEP> COMPOUND <SEP> FINAL <SEP> PRODUCT <tb> Isomer <SEP> R <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> 7 <SEP> 8 <SEP> 9 <SEP> 10 <SEP> R5 <tb> <SEP> O <SEP> CH3 <tb> <SEP> # <SEP> # <tb> (#)-trans <SEP> H <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCCH2- <SEP> #-OCH3 <SEP> H <tb> <SEP> O <SEP> CH3 <tb> <SEP> # <SEP> # <tb> (#)-trans <SEP> H <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> H <SEP> -OCCH2-#-CH3 <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C3H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCCH3 <SEP> H <SEP> -CH3 <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCCH3 <SEP> H <SEP> -C6H5 <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H5 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCN(CH3)2 <SEP> H <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -OCN# <SEP> H <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -C-N#O <SEP> H <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -C-N#NH <SEP> H <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -C-N#N-CH3 <SEP> H <SEP> H <tb> <SEP> O <tb> <SEP> # <tb> (#)-trans <SEP> -C2H7 <SEP> H <SEP> H <SEP> -OH <SEP> H <SEP> H <SEP> H <SEP> -C-NHCH3 <SEP> H <SEP> H <tb> EXAMPLE 14 Pharmaceutical Composition A typical tablet containing 100 mg of active ingredient per tablet is prepared by mixing together with the active ingredient, calcium phosphate, lactose and starch in the amounts shown in the table below. After these ingredients are thoroughly mixed, the appropriate amount of magnesium stearate is added and the dry mixture blended for an additional three minutes. This mixture is then compressed into tablets. Tablet Formula Ingredient Mg. per Tablet Trans-la,2,3,4a,5,6-hexahydro-9- hydroxy-4-propyl-4H-naphth [1,2-b]-1,4-oxazine hydrochloride 100 mg Calcium phosphate 52 mg Lactose 60 mg Starch 10 mg Magnesium Stearate 1 mg Similarly prepared are tablets comprising as active ingredient any of the other novel compounds described herein. Important compounds of the present invention are trans-la,2,3,4a,5,6,-hexahydro-9-methoxy-4-propyl- 4H-naphthtl,2-b]-1,4-oxazine, and the corresponding hydroxy compound, as racemates, or as the (+)-enantiomers with structural formula: EMI44.1 or a pharmaceutically acceptable salt thereof, wherein R3 is -OH or -OCH3. These compounds are prepared by the following additional processes: a.) Reduction of a 4-propionyl group EMI44.2 The reduction is accomplished with a complex metal hydride such as lithium aluminum hydride in an ethereal solvent such as THF, diethyl ether, or dimethoxyethane, preferably THF at about 250C to reflux temperature for about 1/2 to 4 hours. b) Reductive Alkylation of a 4-hydrogen compound EMI45.1 The reductive alkylation is accomplished by treating the compound, unsubstituted at nitrogen, with propionaldehyde, a noble metal hydrogenation catalyst such as palladium on carbon, palladium on barium sulfate, platinum oxide or the like and hydrogen in an inert solvent such as a C13 alkanol, preferably ethanol, for about 2 to 10 hours at about 150C to reflux temperature, preferably at room temperature. Alternatively, the reductive alkylation is performed with propionaldehyde, and sodium cyanoborohydride in an inert solvent such as a C13 alkanol, preferably methanol for about 0.5 to 3 hours at about 150C to reflux temperature, preferably about room temperature. c) Double Condensation Tetrahydro-oxazine Ring EMI45.2 where X1 and X2 are the same or different and represent halo, such as bromo or iodo, benzenoid aromatic sulfonyloxy, such as toluenesulfonyloxy, or benzenesulfonyloxy, C13 alkanesulfonyloxy, such as methanesulfonyloxy, ethanesulfonyloxy, or propanesulfonyloxy. The double condensation is performed by treating the propylamino-alcohol with a 1,2-disubstituted ethane wherein the substituents are good leaving groups such as described, with an alkali metal hydroxide such as sodium or potassium hydroxide in an inert organic solvent such as acetonitrile, methylene chloride, chloroform or the like, preferably in the presence of a phase transfer agent such as methyl tricaprylyl ammonium chloride at about 150C to reflux temperature for about 18 to 36 hours. d) Closure of the Tetrahvdro-oxazine ring. EMI46.1 wherein X is a facile leaving group such as bromo, iodo, benzenoid arylsulfonyloxy such as toluenesulfonyloxy, benzenesulfonyloxy, or C13 alkanesulfonyloxy such as methanesulfonyloxy, ethanesulfonyloxy or propanesulfonyloxy. The ring closure is performed by treatment of the starting material with a strong base, such as sodium hydride, potassium t-butoxide or the like in an inert organic solvent such as THF, or acetonitrile or mixtures thereof with a trace of a C13 alkanol such as ethanol. The reaction proceeds at room temperature but any temperature from about 150C to reflux may be employed for periods of about 0.5 hr to 6 hours. An alternate procedure comprises the ring closure of compound 7 wherein X is -OH and is accomplished by treatment of 7 (X=OH) with diethylazodicarboxylate and triphenylphosphine in an anhydrous aprotic solvent such as ether, or THF at room temperature or below, to about -100C, for about 0.5 to 12 hours. (e) Reduction of a 4-allyl group EMI47.1 This reduction comprises treating the alkyl compound with hydrogen in the presence of a noble metal catalyst such as platinum oxide, palladium on carbon, palladium on barium sulfate or the like in a C13 alkanol, preferably ethanol at about 150C to reflux temperature until one mole of hydrogen/mole of starting material is absorbed. F) Methylation of the Phenolic Hydroxy EMI48.1 The methylation is performed with methyliodide in the presence of a strong base such as sodium hydride or potassium t-butoxide in an ethereal solvent such as THF, ether, dimethoxyethane or the like at about 150C to reflux for about 0.5-6 hours. Alternatively, dimethylsulfate may be used in concentrated aqueous alkali such as sodium or potassuim hydroxide at about 150C to about 500C. If the methoxy compound is a racemate or is otherwise optically impure it can be resolved to obtain the (+)- and (-)-enantiomers through preferential crystallization of the diastereomeric salts produced by treatment with one enantiomer of an optically active organic acid such as di-p-tolyltartaric acid or tartaric acid followed by isolation of the optically enriched free base components The 9-methoxy compound of this invention is converted to the corresponding hydroxy analog by a variety of reagents and conditions. These include pyridine hydrochloride at about 150 to 2500C for about 3 to 8 hours; boron tribromide or aluminum chloride in an inert solvent such as petroleum ether, toluene, hexane, methylene chloride or tetrachloroethane between room temperature and reflux for 3 to about 8 hours; trimethylsilyl iodide at about 0 to 500C for about 2 to 8 hours followed by simple acid hydrolysis; sodium cyanide in dimethylsulfoxide at about 150 to 2000C for 3 to about 8 hours; sodium benzylselenolate in refluxing dimethylformamide for 1/2 to about 3 hours; an alkali metal alkoxide such as lithium thiomethoxide, sodium thioethoxide or lithium thiopropoxide at about 100 to 1500C for 18 to 48 hours; lithium iodide in a basic solvent such as 2,4,6-collidine at about 150 to 2000C for about 6 to 12 hours; sodium p-thiocresolate hexamethylphosphoric triamide in refluxing toluene until the reaction is complete; thioethoxide in dimethylformamide at room temperature to about 1000 for 3 to about 12 hours; boron tribromide/sodium iodide/15-crown-5 in dry methylene chloride at about -50 to -100C for 2 to 5 hours; boron trichloride or tribromide and dimethylsulfide in refluxing 1,2-dichloroethane; and refluxing 48% HBr. The following Examples 15-22 are examples of alternate processes for the preparation of (+) -trans- la,2,3,4a,5,6-hexahydro-9-methoxy-4-propyl-4H-naphth- [1,2-b]-1,4-oxazine hydrochloride. Employing the same reactions described in these examples but using (+)or (-)- optically active starting materials there are obtained the (+)- or (-)- products. Alternatively, the racemic products are resolved into the (+)- or (-)- products. The corresponding 9-hydroxy compounds are readily available by de-etherification. EXAMPLE 15 Step A: Preparation of trans-la,2,3,4a,5,6,-hexa hydro-9-methoxy-4-propionyl-4H-naphth [1,2-b] - 1,4-oxazine hydrochloride An ethyl acetate (100 ml) solution of trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4H naphth (l,2-b]-l,4-oxazine (2.0 g, 0.01 mole) is treated with 25 ml, of saturated Na2CO3 solution followed by 1 ml of propionyl chloride and the resulting mixture is stirred at room temperature for 1 hr. The ethyl acetate layer is separated, washed with brine, dried over Na2SO4 and then concentrated in vacuo and the residue is used directly in the next step. Step B: Preparation of trans-la,2,3,4a,5,6-hexa hydro-9-methoxy-4-propyl-4H-naphth [1,2-b]- 1,4-oxazine hydrochloride The residue from Step A is taken up in THF (40 ml) and added dropwise to a suspension of LAH (300 mg) in THF (40 ml). The reaction mixture is heated at reflux for 1 hr, cooled in ice and excess LAH destroyed with isopropanol. The mixture is treated with methylene chloride (75 ml), saturated Na2SO4 solution (2 ml), and then filtered (supercell ). The filtrate is concentrated in vacuo and the residue taken up in ether followed by addition of several ml of ethanolic hydrochloric acid affords the subject compound as a white solid. EXAMPLE 16 Prepartion of trans-la,2,3,4a,5,6,-hexahydro-9methoxy-4-propyl-4H-naphth [1,2-b]-1,4-oxazine hydrochloride A mixture of trans-la,2,3,4a,5,6-hexahydro-9methoxy-4H-naphth [1,2-b-]-1,4-oxazine (2.0 g, 0.01 mole), propionaldehyde (0.6 g, 0.01 mole), 10% Pd/C catalyst (0.5 g) in ethanol (75 ml) is placed on a Parr apparatus and hydrogenated for 5 hrs. The reaction is removed, filtered, and the solvent removed in vacuo. The residue is dissolved in ether and treated with ethanolic HC1 to afford the subject compound as a white solid. EXAMPLE 17 Preparation of trans-la,2,3,4a,5,6-hexahydro-9methoxy-4-propyl-4H-naphth [1,2-bl-1,4 oxazine hydrochloride A methanol solution of trans-la, 2, 3, 4a, 5, 6-hexahydro-9-methoxy-4H-naphth[l,2-b] -1,4- oxazine (2.0 g, 0.01 mole) and propionaldehyde (0.6 g, 0.01 mole) is stirred mechanically as a solution of sodium cycanoborohydride (0.6 g, 0.01 mole) in methanol is added dropwise. After 1 hr the reaction mixture is poured into water (200 ml) and then extracted with ether (2 x 50 ml). The ether layer is washed with brine, dried over Na2SO4, and filtered. Addition of ethanolic HC1 affords the subject product. EXAMPLE 18 Step A: Preparation of trans-2-propylamino-7 methoxy-1,2,3,4-tetrahydronaphthalen-1-ol A solution of trans-2-propionamido-7-methoxy 1, 2,3,4-tetrahydronaphthalen-1-ol (2.49 g, 0.01 mole) in THF (75 ml) is added dropwise to a stirred suspension of LAH (1.2 g) in THF (40 ml) and then the mixture is heated at reflux for 1 hr. After cooling excess LAH is destroyed by the addition of isopropanol, 75 ml of methylene chloride is added, followed by 25 ml of saturated Na2SO4 solution. This mixture is filtered (supercell), and dried over Na2SO4. Evaporation of the solvent affords the subject compound. Step B: Preparation of trans-la,2,3,4a,5,6-hexahydro 9-methoxy-4-propyl-4H naphth[l,2-b]-4H- oxy ine hydrochloride A mixture of trans-2-propylamino-7-methoxy1,2,3,4-tetrahydronaphthalen-1-ol (2.3g., 0.01 mole), powdered sodium hydroxide (1.6 g, 0.04 mole), 1,2-dibromoethane (7.52 g, 0.04 mole), methyl tricaprylyl ammonium chloride (0.41 g, 0.01 mole), acetonitrile (32 ml) and dichloromethane (48 ml) is stirred at 25-30 for 24 hr, and then powdered sodium hydroxide (0.4 g, 0.01 mole) is added and stirring is continued for an additional 2 hrs. The mixture is filtered and the residue washed with ether. The filtrate is concentrated in vacuo, the resulting residue is dissolved in ether and treated with ethanolic HC1 to afford the subject compound. EXAMPLE 19 Step A: Preparation of trans-2-(N-propyl)ethanol amino-7-methoxy-1,2,3,4-tetrahydro- naphthalen-l-ol A solution of ethylene oxide (0.66 g, 0.015 mole) in THF (20 ml) is added to a stirred solution of trans-2-propylamino-7-methoxy-1,2,3,4- tetrahydronaphthalen-l-ol (2.49 g, 0.01 mole) in THF (75 ml) and stirring is continued for 24 hrs at room temperature. The solvent is removed in vacuo and the residue purified by chromatography to afford the subject compound. Step B: Preparation of trans-2-(N-propyl-N-p-toluene sulfonyloxyethylamino) -7-methoxy-1, 2,3,4- tetrahydronaphthalen-l-ol A mixture containing trans-2-(N-propyl) ethanolamino-7-methoxy-1,2, 3,4-tetrahydronaphthalen-l-o 1 (2.8 g, 0.01 mole) (Step A), p-toluenesulfonylchloride (1.9 g, 0.01 mole), 4-dimethylaminopyridine (100 mg) in methylene chloride is stirred at room temperature for 4 hrs. The reaction mixture is washed with brine, dried over Na2SO4, and then concentrated in vacuo. Step C: Preparation of trans-la,2,3,4a,5,6-tetra hydro-9-methoxy-4-propyl-4H-naphth [1,2-b] 1,4-oxazine hydrochloride The residue from Step B is dissolved in a mixture of THF (25 ml), CH3CN (20 ml), and ethanol (1 ml) and added dropwise to a suspension of NaH (0.48 g, 0.01 mole -50% mineral oil suspension) in THF (25 ml). After stirring for 2 hrs at room temperature the reaction mixture is poured carefully into water and then extracted with ethyl acetate. The ethyl acetate layer is washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue is dissolved in ether and treated with ethanolic HC1 to afford the subject compound. EXAMPLE 20 Preparation of trans-la,2,3,4a,5,6-hexahydro-9methoxy-4-propyl-4H-naphth (1, 2-b] -1, 4-oxazine hydrochloride To a solution of trans-2-(N-propyl)ethanal amino-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol (2.9 g, 0.011 mole) (Step A, Example 19) and triphenylphosphine (4.98 g, 0.019 mole) in T11F (60 ml) is added diethyl azodicarboxylate (2.61 g, 0.015 mole) at 100C. The mixture is stirred at 100 for 4 hrs. and then placed in the refrigerator for 18 hrs. The solvent is removed and the residue stirred with dichloromethane (60 ml) and K2CO3 for 2 hrs. The mixture is filtered and the filtrate chromatographed over silica gel. The proper fractions are collected, concentrated, the residue taken up in ether and ethanolic HC1 added to afford the title compound. EXAMPLE 21 Preparation of trans-la,2,3,4a,5,6-hexahydro-9 methoxy-4-propyl-4H-naphth[1,2-b] -1,4-oxazine hydrochloride An ethanolic solution of trans-la,2,3,4a,5,6 hexahydro-9-methoxy-4-allyl-4H-naphth[1,2-b3-1,4- oxazine (2.59 g, 0.01 mole) containing 0.75 g of 10% Pd/C catalyst is placed on a Parr apparatus and hydrogenated until the proper amount of hydrogen is absorbed. The reaction mixture is removed from the Parr, filtered, and the solvent removed in vacuo. The residue is dissolved in ether and treated with ethanolic HC1 to afford the subject compound. EXAMPLE 22 Preparation of trans-la,2,3,4a,5,6-hexahydro 9-methoxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine hydrochloride To a suspension of NaH (0.48 g, 0.01 mole, 50% mineral oil suspension) in THF (25 ml) is added a solution of trans-la,2,3,4a,5,6-hexahydro-9-hydroxy4-propyl-4H-naphth[1,2-b]-1,4-oxazine (2.4 g, 0.01 mole) in THF (100 ml) over a period of 0.5 hr. When evolution of hydrogen stops the reaction mixture is cooled in ice and 1.4 g of methyl iodide is added. The reaction is stirred at room temperature for 4 hrs and then 1.0 g of additional methyl iodide added. After an additional 2 hrs a few drops of ethanol are added and then the solvent is removed in vacuo. The residue is purified by chromatography (SiO2-solvent CH2Cl2-acetone 9:1). The proper fractions are collected and concentrated. The residue is dissolved in ether and ethanolic HC1 added to afford the subject compound. EXAMPLE 23 Resolution of trans-1a,2,3,4a,5,6-hexahydro-9-methoxy4-propyl-4H-naphth[1,2-b]-1,4-oxazine hydrochloride To 27.0 g (0.10 mole) of trans-la,2,3,4,5,6 hexahydro-9-methoxy-4-propyl-4H-naphth [1,2-b3 -1,4- oxazine was added 41.6 g (0.10 mole) of di-p-toluoyld-tartaric acid (from natural tartaric acid) in 650 ml of 95% ethanol, and the mixture was heated to produce a solution. After cooling and seeding, the mixture was allowed to stand overnight at room temperature after which the salt was collected by suction filtration to give 29.2 g of partially resolved material. Recrystallization from 300 ml of 95% ethanol gave 23.6 g of (-)-salt; [a]D25-109.3 (pyridine). The mother liquor from the first crystallization of the di-p-toluoyl-d-tartaric acid salt from above was concentrated, and the residue was partitioned between saturated aqueous NaHCO3 and CH2C12. After drying (Na2SO4) and concentration, the residue was combined with 23.2 g (0.058 mole) of di-p-toluoyl-l-tartaric acid (from unnatural tartaric acid) and the mixture was crystallized from 350 ml of 95% ethanol. After cooling and seeding, the mixture was allowed to stand overnight at room temperature after which filtering 25 gave 11.0 g of (+)-salt; E 1D5 + 97.220 (pyridine). The (+)- and (-)-salts from above were each partitioned between saturated aqueous NaHCO3 and CH2C12. After drying (Na2SO4) and concentrating, each of the residual free bases was recrystallized from 30-600C b.p. petroleum ether by cooling to -20 C. Filtration of each gave materials having the following properties: (-)-"compound"; mp 45-470C; [a]D5 -62.70 (c, 0.69, CH30H); (+)-"compound"; mp 44-460C; [cr]D +56.60 (c, 0.70, CH30H); EXAMPLE 24 (+) -trans-la,2,3,4a,5,6-hexahydro-9-methoxy-4-propyl- 4H-naphth[1,2-b]-1,4-oxazine via resolution To 13.0 g (0.05 mole) of racemic trans1a,2,3,4a,5,6-hexahydro-9-methoxy-4-propyl-4H-naphth [1,2-b]-1,4-oxazine in 500 ml of 95% ethanol was added 20.2 g (0.05 mole) of di-p-touoyl-l-tartaric acid (from unnatural tartaric acid), and the mixture was heated to produce a solution. After cooling and seeding, the mixture was allowed to stand overnight at room temperature and the salt was collected by suction filtration to give 9.1 g of partially resolved material; m.p. 170-172 C' [&alpha;]D25 + 103.9 (C, 0.59, pyridine). This salt was recrystallized from 95 ml of 95% ethanol to give 6.8 g of salt which was partitioned between saturated aqueous NaHCO3 and CH2C12. After drying (Na2SO4) and concentrating the CH2C12 solution, 2.7 g (0.01 mole) of free base was isolated. This material was mixed with 1.5 g (0.01 m) of d-tartaric acid in ethanol, and the solution was heated and concentrated to about 30 ml. After standing for several days, 2.8 g of salt were collected by filtration. This material was resuspended in 75 ml of ethanol with heating and allowed to cool slowly. The salt was filtered and the mother liquor concentrated to a residue which was partitioned between saturated aqueous NaHCO3 and CH2C12. After drying (Na2SO4) and concentrating, the residue was recrystallized from 30-600C b.p. petroleum ether by cooling to about -200C. Filtration and drying gave 25 650 mg of (+)="title compound"; m.p. 46-470C; [a]D5 + 61.30 (c, 0.65, CH3OH).

Claims: WHAT IS CLAIMED IS: 1. A process for the preparation of a compound of structural formula I: EMI59.1 with positive, negative or zero optical activity, and salts thereof, wherein: R is a) hydrpgen, b) C1-4 alkyl, c) C2-5 alkenyl, d) phenyl-C1-4 alkyl; and R1, R2, R3 and R4 are independently: : a) hydrogen, b) C1-4 alykl, c) halo, d) OR6 wherein R6 is 1) hydrogen 2) C1-3 alykl, 3) phenyl-C1-3-alkyl, 4) -C-R( wherein R7 is i) C1-6 alkyl ii) C3-6 cycloalkyl iii) benzenoid aryl-C1-3 alkyl, wherein the aryl group is unsubstituted or substituted with one ormore halo, C13 alkyl, or C1-3 alkoxy iv) heteroaryl-C1-3 alkyl v) benzenoid aryl, either unsub stituted or substituted with one or more halo, C13 alkyl, or C1-3 alkoxy, vi) heteroaryl and vii) -NR8R9, wherein R8 and R9 are independently hydrogen or C1-3 alkyl, or R8 and R9 may be joined together to form a hetero cycle with the nitrogen to which they are attached, or e) twoadjacent groups selected from R1, R2, R3 and R4 form together an alkylene-di oxy group and R5 is hydrogen, C1 5 alkyl or phenyl, which comprises the reduction of a compound of structural formula II: EMI60.1 with positive, negative or zero optical activity followed, if desired wherein R is hydrogen, by alkylation or alkenylation to provide the compound wherein R is C14 alkyl, C15 alkenyl, or phenyl-C1-4 alykl and/or followed, if desired, when one or more of R1, R2, R3 and R4 is C1-3 alkoxy, phenyl-C1-3 alkoxy, or two are adjacent groups selected from R1, R2, R3, R4, taken together are an alkylene-dioxy group, by deetherification to provide the compound wherein one or more of R1, R2, R3 and R4 is hydroxy; and/or followed, if desired by acylation or carbamylation with an anhydride of formula (R7CO)2O or acid chloride of structure R7COC1 to produce the compound wherein one or more of R1, R2, R3 and R4 is EMI61.1 and, thereafter, isolating the compound of formula I or a salt thereof. 2. Process according to patent claim 1 characterized in that compounds of formula I or salts thereof are prepared wherein R and R5 have the same meaning as in claim 1 and R1, R2, R3 and R4 are independently: a) hydrogen, b) C14 alkyl, c) halo, d) oR6 wherein R6 is 1) hydrogen 2) C1-3 alkyl, 3) phenyl -C1-3 alkyl, EMI62.1 wherein R7 is i) C1-6 alkyl ii) C36 cycloalkyl iii) phenyl-C1-3 alykl, wherein the phenyl group is unsubstituted or substituted with one or more halo, C13 alkyl, or C1-3 alkoxy iv) pyridyl-C1-3 alkyl or furyl C1-3 alykl v) phenyl, either unsubstituted or substituted with one or more halo, C1-3 alkyl, or C1-3 alkoxy, vi) pyridyl or furyl and vii) -NR8R9, wherein R8 and R9 are independently hydrogen or C1-3 alkyl, or R and R9 may be joined together to form with the nitrogen to which they are attached a heterocycle selected from piperidinyl, morpholinyl, piperazinyl and N-C13 alkylpiperazinyl or e) two adjacent groups selected from R1, R2, R3 and R4 form together a methylene-di oxy group. 3. Process according to patent claim 1 or 2, characterized in that compounds of structural formula Ia: EMI63.1 with positive, negative or zero optical activity, or salts thereof are prepared wherein R has the same meaning as in formula I and R1, R2, R3 and R4 are independently: : a) hydrogen, b) C14 alkyl, c) halo, d) OR6 wherein R6 is 1) hydrogen 2) C1-3 alkyl or 3) phenyl-C1-3 alkyl, or e) two adjacent, selected from R1, R2, R3 and R4 form together a methylene dioxy group and preferably compounds of formula Ia are prepared, wherein R is n-propyl, R3 is hydroxy or methoxy and R1, R2 and R4 are hydrogen, in which process a compound of structural formula IIa EMI64.1 with positive, negative or zero optical activity, is reduced, followed, if desired wherein R is hydrogen, by alkylation to provide the compound wherein R is C14 alkyl, C1,5 alkenyl, or phenyl-Cl 4alkyl, and/or followed, if desired, when one or more of R1, R2, R3 and R4 is C1-3 alkoxy, phenyl-C1-3 alkoxy, or R groups taken together are methylenedioxy, by deetherification to provide the compound wherein one or more of R1,- R2, R3 and R4 is hydroxy and wherein thereafter the compounds of formula Ia or a salt there are isolated. 4. A process for the preparation of a compound of structural formula Ib EMI64.2 with zero or positive optical activity wherein R3 is -OH or -OCH3 or a salt of the compounds of formula Ib which comprises: (a) reduction of the 4-propionyl group a compound of structural formula: EMI65.1 with zero or positive optical activity followed, if desired, by optical resolution to the positive enantiomer followed, if desired, by demethylation to produce the compound wherein R3 is -OH; (b) reductive alkylation of a 4-hydrogen compound of structural formula: : EMI65.2 with zero or positive optical activity by treatment with propionaldehyde and a reducing agent followed, if desired by optical resolution to the positive enantiomer followed, if desired, by demethylation to produce the compound wherein R3 is OH; (c) double condensation tetrahydro-oxazine ring formation by treatment of a compound of structural formula: EMI66.1 with zero or positive optical activity with a compound of structural formula : : X' - CH2CH2 - X2 wherein X' and X2 are the same or different and represent bromo,, iodo, benzenoid aromatic sulfonyloxy, or C13 alkanesulfonyloxy, followed if desired b optical resolution to the positive enantiomer, followed if desired by demethylation to produce the compound wherein R3 is OH; (d) closure of the tetrahydro-oxazine ring by treatment of a compound of structural of structural formula: EMI66.2 with zero or positive optical activity wherein X is bromo, iodo, benzenoid arylsulfonyloxy, C¯3 alkanesulfonyloxy or hydroxy, with a condensing agent, followed if desired by optical resolution to the positive enantiomer, followed if desired by demethylation to produce the compound wherein R3 is OH; (e) reduction of a 4-allyl group by treatment of a compound of structural formula: : EMI67.1 with zero or positive optical activity with a reducing agent followed if desired by optical resolution to the positive enantiomer, followed if desired by demethylation to produce the compound wherein R3 is OH; (f) methylation of a compound of structural formula: EMI67.2 with zero or positive optical activity by treatment with a methylating agent, to produce the compound 3 wherein R3 is -OCH3 followed if desired by resolution to the positive enantiomer; (g) reduction of a compound of structural formula: EMI68.1 with zero or positive optical rotation by treatment with a reducing agent, followed if desired by optical resolution to the positive enantiomer, followed if desired by demethylation to produce the compound wherein R3 is OH; and furthermore isolation of the compound of formula Ib or the salt thereof. 5. A compound of structural formula I: EMI68.2 with positive, negative or zero optical activity, or salts thereof, wherein: R is a) hydrogen, b) C1-4 alykl, c) C2-5 alkenyl, d) phenyl-C1-4 alkyl; and R3 and R4 one independente. R R2, R3 and n are independentlys a) hydrogen, b) C1-4 alkyl, c) halo, d) OR6 wherein R is 1) hydrogen 2) C1-3 alykl, 3) phenyl-C1-3 alkyl, 4) -C-R7 wherein R7 is O i) C1-6 alykl ii) C3-6 cycloalkyl iii) benzenoid aryl-C1-3 alkyl, where in the aryl group is unsubstituted or substituted with one or more halo, C1-3 alkyl, or C1-3 alkoxy iv) heteroaryl-C1-3 alkyl t) benzenoid aryl, either unsub- stituted or substituted with one or more halo, C1-3 alkyl, or C1-3 alkoxy, vi) heteroaryl and vii) -NR8R9, wherein R8 and R9 are independently hydrogen or C13 alkyl, or and R9 may be Joined together to form a hetero cycle with the nitrogen to which they are attached, or e) two adjacent groups selected from R1, R20 R3 and R4 form together an alkylene-di oxy group and R5 is hydrogen, C1-3 alkyl or phenyl. 6. Compound of formula I according to claim 4, wherein R1 and R5 have same meaning as in claim 5 and R1, R2, R3 and R4 are independently: a) hydrogen, b) C1-4 alkyl, c) halo, d) OR6 wherein R6 is 1) hydrogen 2) C1-3 alkyl, 3) phenyl-C1-3 alkyl, 4) -C-R7 wherein R7 is # O i) C1-6 alykl ii) C3-6 cycloalkyl iii) phenyl-C1-3 alkyl, wherein the phenyl group is unsubstituted or substituted with one or more halo, C13 alkyl, or C1-3 alkoxy iv) pyridyl-C1-3 alkyl or furyl C13 alkyl v) phenyl, either unsubstituted or substituted with one or more halo, C1-3 alkyl, or C13 alkoxy, vi) pyridyl or furyl and vii) -NR8R9, wherein R8 and R9 are independently hydrogen or C1-3 alkyl, or R8 and R may be joined together to form with the nitrogen to which they are attached a heterocycle selected from piperidinyl, morpholinyl, piperazinyl and N-C1-3 alkylpiperazinyl or e) two adjacent groups selected from R1, R2* R3 and R4 form together a methylene-di oxy group. 7. Compound of claim 5 or 6 having the structural formula Ia EMI71.1 with positive, negative or zero optical activity, or a pharmaceutically acceptable salt thereof, wherein: R has the same meaning as in formula I of claim 5 and R1, R2, R3 and R4 are independently: a) hydrogen, b) C14 alkyl, c) halo, d) oR6 wherein R6 is 1) hydrogen 2) C1-3 alkyl or 3) phenyl-C1-3 alkyl, or e) two adjacent groups selected from R1, R2, R3 and R4 form together a methylene dioxy group and preferably a compound of formula Ia wherein: R- is n-propyl, R3 is hydroxy or methoxy and R , R2 and R are hydrogen. 8. A pharmaceutical formulation for the treatment of Parkinsonism or hypertension which com- prises as active ingredient a compound of structural formula I: EMI72.1 with positive or zero optical activity, or a pharmaceutically acceptable salt thereof, wherein: R, R1, R2, R3, R4 and R5 have the same meaning as in claim 5. 9. A pharmaceutical formulation according to claim 8, characterized in that it comprises as active ingredient a compound of formula I according to claim 6 or a pharmaceutically acceptable salt of said compound of formula I and, furthermore, a pharmaceutical carrier material. lO. A pharmaceutical formulation according to claim 8 or 9, characterized in that it comprises as pharmaceutically effective compound a compound of formula Ia according to claim 7 or a pharmaceutically acceptable salt thereof and, furthermore, a pharmaceutical carrier material.

Inventors: GRENDA, VICTOR J., JONES, JAMES H., MCCLURE DAVID E.
Applicants: MERCK & CO. INC.
Application year: 1982
Main classification: C07D265
IPC codes: C07D265, C07D498, A61K31, C07D413, A61P9, A61P25