PROCESS FOR THE SYNTHESIS OF ARYLOXY DERIVATIVES

Abstract: Process for the synthesis of compounds of formula I (FORMULA) wherein O, is a substituted or unsubstituted aryl or heteroaryl group and U and V may be chosen from a range of substituents including hydrogen, halogen, alkyl and alkoxy; the process comprising reacting a sulfate ester of formula II, wherein Q is a cation, with a compound of formula III, wherein L is a leaving group (FORMULA) and hydrolysing the sulfate ester formed. Preferably the sulfate ester of formula II is prepared by the oxidation of a phenol of formula IV with a persulfate.

Description: Process for the Synthesis of j- ryloxy Derivatives TECHNICAL FIELD This invention relates to a process for the synthesis of organic compounds and in particular to a process for the synthesis of 4-(aryloxy) henol derivatives. BACKGROUND ART 4-(Aryloxy)phenol derivatives are " useful inter¬ mediates for the synthesis of a wide range of fe-(aryloxy)phenox^;7al3ane derivatives which have been shown to have herbicidal activity. In the past the required 4-(aryloxy)phenol derivatives have been pre¬ pared either: i) by condensing the appropriate 4-alkoxyphenol with the appropriate aryl derivatives to give a /4-(alkoxy)phenox/arγl derivative and then cleaving the alkyl residue from the 4-alkoxy group; or ii) by condensing the appropriate hydroquinone with the appropriate aryl derivative. However, both of these processes suffer the dis¬ advantage of using relatively expensive hydroquinone OMPI (derivatives) and the first process suffers the additional disadvantage of requiring the use of relatively expensive reagents to cleave the alkyl residue from the 4-alkoxy group. DISCLOSURE OF I.NVENTION It has now been foun that 4-(a.ryloxy)phenol derivatives may be prepared from the appropriate phenol obviating the need to use a hydroquinone or a 4- alko-xyphenol. Accordingly the invention provides a process for the synthesis of a compound of formula I V where¬ in 0 is an aryl group, a heteroaryl group, a substi¬ tuted aryl group, or a substituted heteroaryl group; and ϋ and V aure independently chosen from the group con¬ sisting of hydrogen, halogen, nitro, cyano, thiocyano, C, to Cg alkyl, C, to C g haloalkyl, C 2 to C g alkenyl, C- to C g haloalkenyl, C, to C g alkoxy, C, to C g haloalkoxy, C, to C g alkylthio, carboxy, (C, to C g alko.xy) carbonyl, phenyl, phenoxy, phenylthio and the groups substituted phenyl, substituted phencxy and substituted phenylthio wherein in each group the phenyl ring is substituted with from 1 to 3 substituents chosen from the group consisting of halogen, n tro, cyano, C, to Cg alkyl, C, to C g haloalkyl and C, to C fi alkoxy; PI which process is characterised in that it comprises the following steps in sequence: a) reacting a sulfate ester of formula II, V wherein Q is a cation, with a compound of formula III, 0-L III wherein L is a leaving group; and b) hydrolysing the sulfate ester formed in step a) to give a compound of formula I. The sulfate ester of formula II may be readily formed by oxidation of a phenol with persulfuric acid or a salt thereof. Accordingly, in a preferred embodi¬ ment the invention provides a process for the synthesis of a compound of formula I as hereinbefore defined which process comprises: i) oxidizing a compound of formula IV with persulfuric acid or a salt thereof to form a sulfate ester of formula II, OM wherein Q is a cation; and ii) which process is characterised by the following steps in sequence: a) react.ing the sulfate ester of formula II with a compound of formula III, 0-L III wherein L is a leaving group; and b) hydrolysing the sulfate ester formed in step a) to give a compound of formula I. The nature of the cation Q in the compound of formula II is not critical. Suit-able Q include the hydrogen ion, the alkali and alkaline earth metal ions and the ammonium ion- The nature of the leaving group L in the compound of formula III is not critical. For example, suitable- leaving groups may be chosen from halogen, nitro, C^ to Cg alkylthio, C, to C g alkylsulfonyl, C, to C g haloalkylsulfonyl, a.rylo.xy such as phenoxy, arylthio such as phenylthio, arylsulfσnyl such as benzenesulfonyl, aralkylsulfonyl such as benzylsulfonyl, alkarylsulfonyl such as p_-toluenesuifonyl, C. to C g alkyls lfonylα.χy, C-, to Cg haloalkyIsulfonyl xy, a.rylsulfonyloxy such as benzenesulfonylOaXy, aralkysulfonyloxy such as benzyl- sulfonyloxy, alka^lsulfonyloxy such as £-toluene- sulfonyloxy, C, to C,- alkylsulfonamido, C-i to C s halo- ffl 10 11 12 θ a.2cyl.sulfonamido and the group -NR R R X wherein R , R and R are chosen from C, to C-, alkyl, phenyl Λ. TO il 12 and benzyl or -KR" R R is a heterocyclic group such as, for example, I-methyl-1-pγrrolio, 1-methyl-l- imidazolio, 1-methyl-l-pyrrolidinio, 1-methyl-l- pyrrolinio,1-methyi-l-imidazolinio, 1-methyl-l- piperidinio, 4-me h l-4-morpholinio, 1-pyridxnio, 1- pyrazxnxo, 1-ρyrimidiniσ* and 1-pyridazinio, and X is a suitable anion including the anions of strong acids such as, for example, hydrochloric acid, hydrobro ic acid, hydriodic acid, tetrafluoroboric acid, hexafluoro- phosphoric acid, hexafluoroantimonoic acid, methane- sulfonic acid, fluorosulfonic acid, fluoromethanesulfonic acid and trifluoromethanesulfonic acid. In the compound of formula I: Preferred 0 include aryl and heteroaryl groups of the formula: OM wherein A, B, D, E .and J are independently chosen from the group consisting of hydrogen, halogen, nitro, cyano, thiocy-ano, a ino, C, to C g alkylam.ino, di(C-, to Cg alkyl) amino, C χ to C g a.lkyl, C^ to C g haloa.lkyl, C- to Cg alkenyl, C 3 to C-- cycloalkyl, C^ to C g alkoxy, C, to Cg haloalko.xy, C^ to Cg alkylthio, C χ to Cg alkylsulfinyl, C, to Cg alkylsulfonyl, C^ to Cg halo- alkylsulf.inyl,. C, to C g haloalkylsulfonyl, sulfo, C, to Cg alkoxysulfonyl, sulfamoyl, N-CC^ to Cg alkyl)- sulfamoyl, N, -di(C, to C g alkyl) sulfamoyl, carboxy, (C, to Cg alkoxy) σarbonyl, carbamoyl, N-(C, to C g ' - alkyl)carbamoyl, N,N-di(C-, to C g alkyl) carbamoyl, phenyl,. pb.eno.xy, phenylthio, and the groups substituted phenyl, -substituted phenoxy and substituted phenylthio wherein in each group the phenyl ring is substituted ' with from 1 to 3 substituents chosen from the group consisting of halogen, C, to C g aJLkyl, C, to C- haloalkyl, C, to C g alkoxy, nitro and cyano; X is chosen * from the group consisting of oxygen, sulfur and NR wherein R is chosen from hydrogen and C, to C-. alkyl; k, 1 and m are .independently chosen from 0 and 1 provided that k + l + m is 0, 1 or 2. Preferred-.A, B, D and Ξ include hydrogen, halogen, nitro, cyano, amino, C, to C- a.lkylamino, d• i(C j _ to Cg alkyl) amino, C L to C g alkyl, C, to C g haloa.lkyl, C 2 to. C g alkenyl, C^ to C g alko:xγ, C, to C g haloalkoxy, C 1 to C g alkylthio, carboxy and C, to C g alkoxycarbonyl. More preferred A, B, D and Ξ include OMP hydrogen, halogen, nitro and trifluoromethyl. Preferred J include hydrogen, halogen, nitro, cyano, C, to C g alkyl and C- j^ to C g haloalkyl. More preferred J include hydrogen and halogen. Preferred X include oxygen, sulfur and NR wherein is hydrogen or methyl. More preferred X include oxygen and sulfur. Preferred k, 1 and m are 0 or 1 wherein k + 1 + is 0 or 1. More preferred k, 1 and m are 0. Preferred ϋ and V include hydrogen, halogen, nitro, cyano, C, to C g alkyl, C, to C g haloalkyl, and m to C g alkoxy. More preferred ϋ and V include hydrogen and halogen. In the compound of formula II preferred Q include the alkali metals such as, for example, sodium and potassium, and ammonium. In the compound of formula III preferred L in¬ clude the halogen atoms chlorine, bromine and iodine, methanesulfonyl, trifluoromethanesulfonyl, p_-toluene- sulfonyl, methanesul onyloxy, trifluoromethane- sulfonylo.xγ, £-toluenesulfonyloxy, trifluoro ethane- sulfonamido and 1-pyrimidino p_-toluenesulfonate. Step a) of the process of the invention may be carried out under a wide range of operating conditions. Preferably the reaction is carried out in the presence of an alkaline material. Suitable- alkaline materials include the alkali metal and alkaline earth metal hydroxides and carbonates such as, for example, sodium, hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate. Step a) of the process of the invention is also preferably carried cut in the presence of an organic solvent. Suitable solvents include: alcohols such as, for example, methanol, ethanol, n-propanol and iso- propancl; ketones such as, for example, acetone, methyl O ethyl ketone .and methyl isobutyl ketone; and dipolar aprotic solvents such as, for example, dimethyl- fo.rmamide, dimethylacetamide, dimethylsulfoxide, N- me hylpyrrolidone, hexamethylphosphoramide and sulfolan. The specific reaction conditions required to effect the reaction in step a) of the process of the in¬ vention will vary with the specific reactants and sol¬ vent used. In general the reaction is facilitated by the application of heat and usually a reaction temperature in the range of from 40 to 150 C and a reaction time of between 0.5 and 20 hours is satis¬ factory. However, higher or lower reaction tempera¬ tures and/or shorter or longer reaction times may be employed if desired. On completion of the reaction in step a) of the process of the invention the compound of formula I may be formed by hydrolysis of the sulfate ester according to step b) of the process of the invention. The sulfate ester formed in step' a) of the process of the invention may be hydrolysed without isolation from the reaction mixture, or alternatively the sulfate ester may be isolated from the reaction mixture' and then hydrolysed. If step b) of the process of the invention is carried out without the isolation of the sulfate ester, conveniently, the compound of formula I may be formed in situ by acid hydrolysis. For example, the reaction mixture formed, in step a) of the process of the inven¬ tion may be acidified,, for example with a mineral acid, for example, cetic acid, to hydrolyse the sulfate ester. In general the hydrolysis reaction is facilitated, by the application of heat. Alternatively, the sulfate ester formed in step a) of the process of the invention may be isolated from the reaction mixture before hydrolysis . Convenient¬ ly, the sulfate ester may be isolated by removing the O PI solvent from the reaction mixture formed in step a ) of the process of the invention. For example, if step a ) of the process of the invention was carried out in aqueous solution the reaction mixture may be extracted with a water-immiscible organic solvent, optionally after acidification of the reaction mixture, to remove any unreacted compound of formula III from the reaction mixture. The solvent may then be removed from the aqueous solution, for example by distillation, distillation under reduced pressure, evaporation or freeze-dr ing, and the sulfate ester may be purified as required. The sulfate ester may then be hydrolysed to form a compound of formula I, for example, by hydrolysis with an aqueous mineral acid such as hydro- chloric acid or an organic acid such as acetic acid. Preferably, the sulfate ester of fo.rmula II. which is used in step a) of the process of the present invention is formed by the oxidation of a phenol of formula IV with persulfuric acid or a salt thereof. The oxidation may be carrie out under a wide range of operating conditions. However, preferably the oxidation is carried out in aqueous alkaline solution using a salt of persulfuric acid. Suitable bases include the alkali metal and alkaline earth metal oxides, hydroxides and * carbonates.. Suitable salts of persulfuric acid include the ammonium salt and the alkali metal salts- such as sodium persulfatε-and potassium persulfate. Convenient¬ ly, the compound of formula IV is dissolved in an aqueous alkaline solution and the oxidizing agent is added slowly * to the solution which is maintained at or below ambient temperature during the addition. On completion of the oxidation process the sulfate ester of formula II may be reacted directly, without isolation, with the compound of formula III or alternatively the sulfate ester may be isolated from the OMPI Yλ * _m IPO reaction mixture and then reacted with the compound of formula III. If the step a) of the process of the invention is carried out without isolation of the sulfate ester, conveniently, the compound of fo:παula III may be simply added to the oxidation reaction mixture and step a) of the process may be carried out in the reaction mixture formed in the oxidation process. If desired, any unreacted compound of formula IV may be removed from the oxidation reaction mixture before carr .ing out step a) of the process of the invention by, for example, acidifying the aqueous reaction mixture formed (eg by the addition of an acid or carbon dioxide) and extract¬ ing the aqueous acid solution with a relatively polar, water-aimmiscible organic solvent. .Any unreacted com¬ pound of formula IV extracted into the organic solvent may be recovered and recycled.. Alternatively, the sulfate ester of formula II formed in the oxidation process may be isolated before reaction with the compound of formula III. Convenient¬ ly, the sulfate ester may be isolated by removing the solvent from the reaction mixture formed in the oxida¬ tion process and extracting the sulfate ester from the residue. For example, the aqueous reaction mixture formed may be acidified (eg by the addition of an acid or carbon dioxide) and extracted with a relatively polar, water-immiscible organic solvent to remove any unreacted compound of foα nula IV from the reaction mixture. The aqueous phase may then be made basic, for example made alkaline to litmus with sodium hydrogen carbonate. The solvent may then be removed from the alkaline solution, for example by distillation, distillation under reduced pressure, evaporation or freeze-drying, and the sulfate ester may then be ex- tracted from the residue. The solvent used to extract OMPI - li ¬ the sulfate ester from the residue will depend to a large extent on the solubility properties of the sulfate ester. However, in general the solvent used will be a polar organic solvent, such as, for example, ethanol or acetone, in order to effect maximum recovery of the sulfate ester combined with as small an amount of in¬ organic salts as possible. After extraction of the sulfate ester, the sulfate ester containing solution may be used directly in step a) of the process of the invention or the sulfate ester may be separated for example by removal of the solvent, and further purified as required. The process of the invention may be used for the preparation of a wide range of 4-(aryloxy)phenols of formula I. For example: 4-/T5-chloropyrimid-2-yl)oxy_/phenol may be prepared by reacting a 4-hydroxyphenylsulfate salt with a 2— substituted-5-chloropyri.midine, such as 5-chloro-2- ethanesulfonylpyrimidine, and hydrolysing the sulfate ester formed; 4-(2-nitro-4-trifluoχ-omethylphenoxy)phenol may be pre¬ pared by reacting a 4-hydro.χyphenylsulfate salt with a 4-substituted-3-nitrobenzotrifluoride, such as 4-chloro- 3-nitrobenzotrifluoride, and hydrolysing the sulfate ester formed; 4-/7β-chloroquino.xalin-2-yl)oxγ/phenol may be prepared by reacting a 4-hydroxyphenylsulfate salt with a 2- substituted-6-chloroquinoxaline, such as 2,6- dichloroquinoxaline, andhydrolysingthe sulfate ester formed; 4-^15-trifluoromethylpyridin-2-yl) oxyJ7phenol may be prepared by reacting a 4-hydroxyρhenylsulfate salt with a 2-substituted-5-trifluoromethylpyridine, such as 2- chloro-5-trifluoromethylpyridine, and hydrolysing the sulfate ester formed; 4-(2,4-dichlorophenσ.xy) henol may be prepared by re¬ acting a 4-hydroxyphenylsulfate salt with a 2- substituted-2,4-dichlorobenzene such as l-bromo-2,4- dichlorobenzene, -and hydrolysing the sulfate ester formed; and 4-(4-trifluoromethyIphenoxy)phenol may be prepared by reacting a 4-hydroxyphenylsulfate salt with a 4- substituted-benzotrifluoride, such as 4-chlorobenzo- trifluoride, and hydrolysing the sulfate ester formed. In the preferred process of the invention the 4-hydroxyphenylsulfate salt used in the foregoing reactions is prepared by the oxidation of phenol using a salt of persulfuric acid. MODES OF CARRYING OUT THE INVENTION The invention is now illustrated by, but in no way limited to, the following Examples. Exam .p—le 1 Preparation of 4-/T5-chloropyrimid-2-yl)oxy7phenol A solution of ammonium persulfate (8.0 g; 35 mmole) in water (30 ml) was added dropwise to a stirred solution of phenol (3.2 g; 35 mmole) in aqueous 10% sodium hydroxide (70 ml) which was maintained at or below a temperature of 20°C throughout the addition. On completion of the addition the solution was allowed to stand overnight at a temperature of 15 to 20 C- 5-Chloro-2-methanesulfonylpyrimidine (6.0 g; 30 mmole) was added and the reaction mixture was heated under reflux for a period of 1.5 hours. After cooling the reaction mixture was extracted with diethyl ether (2 x 100 ml) . The aqueous phase was then made acidic to litmus by the addition of concentrated hydro¬ chloric * acid (10 ml) . The reaction mixture was heated under reflux for a period of 1 hour. After cooling the reaction mixture was extracted with ethyl acetate (4 x 100 ml) , the combined organic extracts were dried (over anhydrous magnesium sulfate) , and the solvent was removed by distillation under reduced pressure. The residue was purified by chromatography over silica gel (eluen-t ethyl acetate) to give 4-/~5-chloropyrimid- 2-yl)oxy/phenol ( ) g) . The product was characterised by comparison with an authentic,sample of 4-_T5-chloropyrimid-2-yl) - oxy_7phenol. The pmr spectrum of the product was identical with the pmr spectrum of the authentic sample and the chromatographic behaviour of the product on thin-layer chromatography was identical with that of the authentic- sample. - • gϋRE O PI Example 2 Preparation of 4-(2-nitro-4-trifluorometh lphenoxy)- phenol A solution of ammonium persulfate (8.0 g; 35 mmole) in water (30 ml) was added dropwise to a stirred solution of phenol (3.2 g; 35 mmole) in aqueous 10% soadium hydroxide (70 ml) which was maintained at or below a temperature of 20 C throughout the addition. On completion of the addition the solution was allowed to stand overnight at a temperature of 15 to 20°C. The solution was made acidic (to Congo red) by the addition of concentrated hydrochloric acid and the acidic solution was extracted with diethyl ether (2 x 500 ml) . The aqueous phase was separated, made alkaline to litmus with aqueous sodium hydroxide solution and the water was removed by evaporation under reduced pressure. The residue was acidified and extracted with aqueous 90% ethanol (200 ml) . The aqueous ethanolic solution was made alkaline and was heated under reflux while 4-chloro-3-nitobenzotrifluoride (8.0 g; 35 mmole) was added dropwise. After heating under reflux for a period of 2 hours the hot solution was made acidic by the addition of concentrated hydrochloric acid and stirred overnight-at room temperature. - The solvent was removed by distillation under reduced pressure and the residue was partitioned between water and dichloro- methane. The organic—phase was separated, dried over anhydrous magnesium sulfate, and the solvent was re¬ moved by distillation under reduced pressure. The residue was chromatographed over silica gel (eluent dichloromethane) to give 4-(2-nitro-4-trifluoromethyl- phenoxy)phenol (0.6 g) as a pale yellow oil. The product was characterised by comparison with -an authentic sample of 4-(2-nitro-4-trifluoro- methylphenoxy)phenol. The pmr spectrum of the product was identical with the pmr spectrum of the authentic sample and the chromatographic behaviour of the product on thin-layer chromatography was identical with that of the authentic sample. Example 3 Preparation of 4-/(6-chIoroquinoxalin-2-yl) oxy7phenol a) Potassium 4-hydro.xyphenylsulfate A solution of potassium persulfate (27.0 g) in water (500 ml) was added dropwise over a period of 2 hours to a stirred solution of phenol (9.4 g) and sodium hydroxide (20.0 g) in water (200 ml) the reaction mixture being maintained at a temperature of 20+2°C throughout the addition. On completion of the addi¬ tion the reaction mixture was stirred for a further period of 24 hours at a temperature of 20 C C. .An ex¬ cess of carbon dioxide was passed through the re¬ action mixture to neutralize the base. The mixture was then extracted with diethyl ether (2 x -200 ml) and the unreacted phenol (2.7 g) was recovered from the ethereal extracts . The aqueous solution was evaporated to dryness under reduced pressure and the solid residue was extracted with an ethanol (20 parts)/ water (1 part) mixture (3 x 500 ml) . The combined aqueous ethanolic extracts were evaporated to dryness to give potassium 4-hydroxyphenylsulfate as a pale brown powder * (10.5 g) , mp 210-220°C. (Found: C, 31.7; H, 2.65; S, 13.9. CgH^SK requires: C, 31.6; H, 2.2; S, 14.0%.) b) 4-^76 -Chloroquinoxalin-2-yl) oxγ/phenol A mixture of potassium 4-hydroxyphenylsulfate (1.14 g; prepared as described in part a) above) 2,6-dichloro- quinoxaline (0.90 g) , anhydrous potassium carbonate (0.70 g) , dimethylformamide (5 ml) and xylene (5 ml) was heated and stirred at a temperature of H0°C for a period of 5 hours. The solvents were removed by O P WIP distillation under reduced pressure, acetic acid (20 ml) was added to the solid residue -and the mixture was heated under reflux for a period of 2 hours . The acetic acid was removed by distillation under reduced pressure and the solid residue was partitioned be¬ tween water ( 1Q0 ml) .and ethyl acetate ( 2 x 200 ml) . The combined organic extracts were dried over anhydrous magnesium sulf te and the solvent was removed by distillation under reduced pressure to give the crude product ( 1.8 g) . The product was chromatographed over silica gel with chloroform elution to give recovered 2 , 6-dichloroquinoxaline (0.1 g) , 2-/ 6-chloroquinoχ.alin-2-yl) oxyJ7phenol (0 .75 g; 64% based on 2 , 6-dichloroquinoxaline used) as a colourless crystalline solid, mp 204-205°C . The product was characterised by comparison with an authentic sample of 4-/Tδ-chloroquinoxalin- 2-yD ox^/phenol. The pmr spectrum of the product was identical with the pmr spectrum of the authentic sample and the melting points and mixed melting point of the product and l:he authentic sample were the same . Exaanple 4 Preparation of 4-/T5-trifluoromethylpyridin-2-yl)ox - phenol A- mixture of potassium 4~hydra.xyph.eny I sulfate (1.14 g; prepared as described in Example 3 part a) ) , 2-chloro-5-tri_£luorσmethylpyridiue (0 .93 g) , anhydrous potassium carbonate (0. 75 g) , dime thy lfo.rmamide (5 ml) and .xylene (5 ml) v;as heated and s irred at a temperature of 85-90 C for a period of 4 hours . The solvents were re¬ moved by distillation under reduced pressure , acetic acid ( 15 ml) was added to the solid residue and the mixture was heated under reflux for a period of 2 hours . The acetic acid was removed by distillation under reduced - ORE OMP pressure and the residue was partitioned between aqueous . 1M sodium bicarbonate solution ( 100 ml) and chloroform ( 2 x 100 ml) . The combined chloroform extracts were dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure to give the product as a pale brown oil . Chromatography over silica gel with chloroform elution gave 4-/T5- trifluoromethylpyridin-2-yl) as an oil ( 0 . 35 g; 28%) . Mass spectrum (m/e , % ) : 255 (M + , 100 ) ; 254 ( 76 ) ; 227 ( 94 ) . Example 5 Preparation of 4-(2,4-dichlorophenoxy)phenol . A mixture of potassium 4-hydroxyphenylsulphate (2.0 g; prepared as described in Example 3 part a)) , bromo-2,4-dichlorobenz ' ene (2.0 g) , anhydrous potassium carbonate (1.4 g) , cuprous oxide (0.1 g) and pyridine (10..ml) was stirred and refluxed under an atmosphere of nitrogen for 16 hours. The pyridine was removed under reduced pressure, acetic acid (20 ml) was added to the residue and the mixture was heated under reflux for a period of 2 hours. The acetic acid was removed by dis¬ tillation under reduced pressure and the residue was partitioned between 2 M aqueous sodium hydroxide (100 ml) and chloroform (50 ml) . The aqueous layer was separated and acidified with hydrochloric acid and then extracted with chloroform (2 x 50 ml) . The chloroform extracts were dried over anhyhdrous magnesium sulphate and the solvent was removed by distillation under reduced pressure to give the product as a brown oil (0..1 g) . The 4-(2,4-dichlorophenoxy)phenol was identified by its pmr and mass spectra. Proton magnetic resonance spectrum: (CDC1,; δ in pp ) 6.7, d, -1H ' ; 6.8, s, 4H; 7.1, d of d,. lH; 7.4, d, 1H. Mass spectrum (m/e, %) : 256 (70) ; 254 (M + , 100) ; 220 (25), 184 (60) . Example 6 4-(4-Trifluoromethylphenoxy) henol was prepared from 4- trifluoromethylchlorobenzene and potassium 4-hydroxy- phenylsulphate following essentially the same procedure as that described in Example 5. The product a pale brown oil was characterized by its mass spectrum (m/e, %) : 254 (M + ) . INDUSTRIAL APPLICABILITY The 4-(arylcxy)phenols which may be prepared according to the. process of the invention are useful intermediates for the synthesis of a wide range of herbicidal, (arylox henoxy) alkane derivatives. In particular, the 4-(arylcxy)phenol derivatives which may be prepared according to the process of the invention are useful intermediates in the preparation of a number of herbicidal 2-(4~aryloxyphenoxy)propionic acid derivatives. The process of the present invention offers a number of advantages over the prior art processes which have been used for the synthesis of such 4-(a.ryIσx ) - phenol derivatives. In the past the required 4- (a.rylo.xy)ρhenol derivatives have been prepared either: i) by condensing the appropriate 4-alkoxyphenol with the appropriate aryl derivatives to give a /4—(alko.xy)phenoxy/a-ryl derivative and then cleav¬ ing the alkyl residue from the 4-alkoxy group; or ii) by condensing the appropriate hydroquinone with the appropriate aryl derivative. However, both of these processes suffer the disadvantage of using relatively expensive hydroquinone (derivatives) . Moreover, the first process suffers the additional disadvantage of requiring the use of _ . OMPI relatively expensive reagents to cleave the alkyl resi¬ due from the 4-alkoxy group while the second process suffers the additional disadvantage of possible reaction at both hydroxyl groups to give bis(aryloxy) derivatives of hydroquinones. It will be evident to those skilled in the art that the process of the present invention offers the advantage of the utilization of relatively in¬ expensive phenol (derivatives) and does not suffer the disadvantages of either the use of relatively expensive reagents or the possible formation of bis(arylo.χy) derivatives of hydroquinones. OMPI

Claims: CLAIMS 1. A process for the synthesis of a compound oj formula I V wherein 0 is an aryl group, a heteroaryl group, a substituted a.ryl group, or a substituted heteroaryl group; and ϋ and V are independently chosen from the group con¬ sisting of hydrogen, halogen, nitro, cyano, thiocyano, C-, to C g alkyl, C, to C g haloalkyl, C to C g alkenyl, C to C g haloalkenyl, C, to C g a.lkoxy, C, to C g haloalko.χy, C, to C g a.lkylthio, carboxy, (C, to C g a.lko.xy) carbσnyl, phenyl, pheno.xy, phenylthio and the groups substituted phenyl, substituted phenoxy and substituted phenylthio wherein in each group the phenyl ring is substituted with from 1 to 3 substi¬ tuents chosen from the group consisting of halogen, nitro, cyano, C, to C alkyl, C, to C g haloalkyl and C, to C g alkoxy; which process is characterised in that it comprises the following steps in sequence: a) reacting a sulfate ester of formula II, wherein Q is a cation, with a compound of formula III, 0-L III wherein L is a leaving group; and b) hydrolysing the sulfate ester formed in step a) to give a compound of formula I. 2. A process for the synthesis of a compound of formula I as defined according to claim I which process comprises: i) oxidizing a compound of fcrmula IV with persulfuric acid or a salt thereof to form a sulfate ester of formula II , f OM O X r * / WIF wherein Q is a cation; and ii) which process is characterised by the following steps in sequence: a) reacting the sulfate ester of formula II with a compound of formula III, 0-L III wherein L is a leaving group; and b) hydrolysing the sulfate. ester formed in step a) to give a compound of fo.rmula I, 3. A process according to claim 1 wherein: step a) is carried outin the presence of a solvent and an alkaline material; and step b) is carriedout using a mineral acid or an organic acid to hydrolyse the sulfate ester. 4. A process according to claim 2 wherein: i) the oxidation of the compound of formula IV is carried out in aqueous aLkaline solution using a salt of persulfuric acid as oxidant; and ii) step a) is carried out in the presence of a solvent and an alkaline material; and step b) is carried out using a mineral acid or an organic acid to hydrolyse the sulfate ester- 5. A process according to claim 1 wherein: OMPI step a) is carried out in the presence of an organic solvent and an alkaline material chosen from the alkali metal and alkaline earth metal hydroxides and carbonates; and step b) is carried out using a mineral acid or an organic acid to hydrolyse the sulfate ester. 6'. A process according to claim 2 wherein: i) the oxidation of the compound of fo.rmula IV is carried out by the slow addition of a salt of persulfuric acid to an aqueous alkaline solution of the compound of formula IV; and ii) step a) is carried out in the presence of an organic solvent and an alkaline material chosen from the alkali metal and alkaline earth metal hydroxides and carbonates; and step b) is carried out using a mineral acid or an organic acid to hydrolyse the sulfate ester. 7. A process according to claim 1 wherein: in the compound of formula I 0 is chosen from aryl and heteraryl groups of the formulae ' OMP wherein A, B, D, E and J are independently chosen from the group consisting of hydrogen, halogen, nitro, cyano, thiocyano, amino, C, to C g alk lamino, dx(C, to C g alkyl)amino, C-. to C g alkyl, C^ to C g haloalkyl, C 2 to C g alkenyl, C, to C_ cycloalkyl, C 1 to C g alkoxy, C, to C g haloalkoxy, C χ to C g alkylthio, C 1 to C g alk lsulfinyl, C, to C g alkyIsulfonyl, ^ to C g halo- alkylsulfinyl, C, to C g haloalk Isulfonyl, sulfo, C 1 to C g alkoxysulfonyl, sulfamoyl, N-(C 1 to C g alkyl)- sulfamoyl, N,N- i(C, to C g alkyl)sulfamoyl, carboxy, (C, to C g alkoxy) carbonyl, carbamoyl, N-(C, * to C g alkyl)carbamoyl, to C g alkyl) carbamoyl, phenyl, phenoxy, phenylthio, and the groups substituted phenyl, substituted phenoxy and substituted phenylthio wherein in each group the phenyl ring is substituted with from 1 to 3 substituents chosen from the group consisting of halogen, C 1 to C g alkyl, C, to C g haloalkyl, C 1 to C g alkoxy, nitro and cyano; X is chosen from the group consisting of cxygen, sulfur and NR wherein R is chosen from hydrogen and C 1 to Cg alkyl; k, 1 and m are independently chosen from 0 and 1 provided that k + 1 + m is 0, 1 or 2; and ϋ and V are independently chosen from the group con¬ sisting of hydrogen, halogen, nitro, cyano, thiocyano, C-, to C g alkyl, C, to C g haloalkyl, C~ to C g alkenyl, C 2 to Cg haloalkenyl, C, to C g alkoxy, C-, to C g haloalkoxy, C, to C g alkylthio, carboxy, (C, to C g alkoxy) carbonyl, phenyl, phenoxy, phenylthio and the groups substituted phenyl, substituted pheno.χγ and substituted phenylthio wherein in each group the phenyl ring is substituted with from 1 to 3 substi¬ tuents chosen from the group consisting of halogen ' O nitro, cyano, C-, to C g alkyl, C-, to C g haloalkyl and C, to C g alkoxy; in the compound of foaπnula II - Q is a cation; and in the compound of foicmula III - L is a leaving group. 8. A process according to claim 2 wherein: in the compound of formula I - Q . is chosen from a^l .and heteroaryl groups of the formulae wherein A, B, D, E and J are .independently chosen from the group consisting of hydrogen, halogen, nitro, cyano, thiocyano, amino, C^ to C g alkyla ino, dKC^ 1 to Cg alkyl)amino, C 1 to C g alkyl, C~_ to C g haloalkyl, C, to C g alkenyl, C 3 to C η cycloalkyl, C^ to Cg alkoxy, C, to Cg haloalkoxy, C 1 to C g alkylthio, C^ to C g alkyIsulfinyl, λ to C g alkyIsulfonyl, C 1 to C g halo- alkylsulfinyl, C, to Cg haloalkylsulfonyl, s ' ulfo, C 1 to Cg alko.xysulfonyl, sulfamoyl, N-(C 1 to C g alkyl)- sulfamoyl, N,N-di(C, to C g alkyl) sulfamoyl, carboxy, (C- j^ to Cg alkoxy)carbonyl, carbamoyl, -ζC^ to C g alkyl)carbamoyl, N,N-di(C 1 to C g alkyl)carbamoyl, phenyl, phenoxy, phenylthio, and the groups substituted phenyl, substituted phenoxy and substituted phenylthio wherein in each group the phenyl ring is substituted with from 1 to 3 substituents chosen from the group consisting of halogen, C, to C. alkyl, C 1 to C 6 haloalkyl, C, to C g alkoxy, nitro and cyano; X is chosen from the group consisting of oxygen, sulfur and NR wherein R is chosen from hydrogen and C, to C g "-g rRE OMP aJJ yl; k, 1 and m are independently chosen from 0 and 1 provided that k + 1 + m is 0, 1 or 2; and U and V are independently chosen from the group con¬ sisting of hydrogen, halogen, nitro, cyano, thiocyano, C, to C g alkyl, C-^ to C g haloalkyl, C 2 to C g alkenyl, C 2 to C haloalkenyl, C^ to Cg alkoxy, C 1 to C g haloalko:xy, C χ to C g a^ylthio, carbojςy, (C χ to C g alkoxy)carbonyl, phenyl, phenoxy, phenylthio and the groups substituted phenyl, substituted phenoxy and substituted phenylthio wherein in each group the phenyl ring is substituted with from 1 to 3 substi¬ tuents chosen from the group consisting of halogen, nitro, cyano, C, to C g aUcyl, C, to C g haloalkyl and C-, to C g alko^ in the compound of fo.rmula II - . Q is a cation; and in the compound of formula III - L is a leaving group. 9. A process according to claim 7 or claim 8 wherein: in the compound of formula I - A, B, D and E are .independently chosen from the group consisting of hydrogen, halogen, nitro, cyano, amino, C l to C 6 al *^ la3ain ° ± l c 2. to c s alkyl) amino , C, to C g alkyl , C χ to Cg haloalkyl , C 2 to C g alkenyl , C, to Cg alkoxy , C^ to C g haloalkoxy , C^- to Cg alkylthio , carbcxy and C, to C g alkoxycarbonyl ; J is chos-en from the group consisting of hydrogen, halogen, nitro , cyano , C 1 to C g alkyl. and C, to C g haloalkyl ; OMPI X is chosen from the group consisting of oxygen, sulfur, and NR wherein R is hydrogen or methyl; k, 1 and m are chosen from 0 and 1 wherein k + 1 + m is 0 or 1; and ϋ and V are independently chosen from the group con¬ sisting of hydrogen, halogen, nitro, cyano, C, to Cg alkyl, C-^ to C g haloalkyl and C, to C g alko.χy; in the compound of formula II - Q is chosen from hydrogen, the alkali and alkaline earth metals and ammonium; and in the compound of fo.rmula III - L is chosen from the group consisting of chlorine, bromine, iodine, methanesulfonyl, trifluoromethane- sulfonyl, £-toluenesulfonyl, methanesulfonyloxy, tri- fluoro ethanesulfonylo-xy, £-toluenesulfonyloxy, tri- fluoromethane sulfonamido and 1-ρyrimidino p_-toluene- sulfonate. 10. A process according to claim 7 or claim 8 wherein: in the compound of fo-rmula I - A, B, D and E are independently chosen from the group consisting of hydrogen, halogen, nitro and trifluoro- methyl; J is chosen from hydrogen and halogen; X is chosen from Oxygen and sulfur; k, 1 and m are 0; and U and V are independently chosen from hydrogen and halogen; in the compound of formula II - Q is an alkali metal or ammonium; and in the compound of fo.rmula III - L is chosen from the group consisting of chlorine bromine or iodine. 11. A process according to claJLm 7 or claim 8 wherein: in the compound of fo*cmula I - 0 is chosen from wherein A, B. D and E are independently chosen from the group consisting of hydrogen, halogen, nitro and tri luoromethy1; J is hydrogen; k, 1 and are 0; and ϋ and V are hydrogen; in the compound of formula II - Q is chosen from sodium, potassium and ammonium; and in the compound of formula III - L is chosen from the group consisting of chlorine, bromine and iodine. 12. A process according to claim 1 or claim 2 for the synthesis of a compound of formula I selected from the group consisting of 4-/T5-chloropyrimid-2-yl)o.x * y_7- phenol, 4-(2-nitro-4-trifluorome hylphenoxy)phenol, 4-/7δ-chloroquinoxalin-2-yl) trifluoromethylpyridin-2-yl)oxγ7phenol, 4-(2,4- dichlorophenoxy)phenol and 4-(4-trifluoromethylpheno.χy)- phenol. 13. A compound of fo.rmula I synthesised according to the process of claim 1 or claim 2. DATED this day of 1981 ICI AUSTRALIA LIMITED

Inventors: WATSON K
Applicants: ICI AUSTRALIA LTD, WATSON K
Application year: 1981
Main classification: C07D241
IPC codes: C07C41, C07C43, C07C65, C07C67, C07C69, C07C201, C07C205, C07C323, C07D213, C07D239, C07D241