DENTAL PROSTHESIS ADHESIVE

Abstract: The invention relates to a dental prosthesis adhesive formed for one or more adhesive substances and characte­ rized in that at least a part of the adhesive substance or substances are provided with a coating which dissolves slowly in saliva and/or ingestive liquids. Preferably the coating for the adhesive substance contains one or more substances selected from the group consisting of ethyl cellulose, saccarose monostearate, gum arabis, cellulose acetate phthalate, acrylate, methacrylate, shellac or other film providing substances.

Description: Dental Prosthesis Adhesive The invention relates to a dental prosthesis adhesive containing one or more adhesive substances as well as a process for producing a dental prosthesis adhesive. It is generally known to produce dental prosthesis adhesives using chemical or natural substances imparting an adhesive action and which are used individually, mixed with one another or distributed in carrier substances. These dental prosthesis adhesives give a natural prosthesis fit, which generally lasts several hours. However, in general, a maximum duration of the adhesive action is desired which should last over a maximum day-period of up to 17 or more hours. Of all known adhesives eventually one would possibly expect such a long adhesive action over the day, but it would be very difficult for the prosthesis wearer to remove the denture during the period in question whenever he would wish to do so because the adhesive action is extremely powerful. It is also extremely difficult to clean such adhesives from the dental prosthesis. Thus, the problem of the invention is to provide a dental prosthesis adhesive permitting a reliable fit over long periods, whilst stillmasing it possible to remove the prosthesis without difficulty. According to the invention, this problem is solved in that the adhesive substance or substances are at least partly provided with a coating which slowly dissolves in the saliva and/or in ingestive liquids. The process of the invention for producing such a dental prostesis aid is characterized by coating the adhesive substance or substances with a coating which slowly dissolves in the salvia and/or in ingestive liquids and mining the coated adhesive substance or substances with coated adhesive substance or substances. Accordingly, the invention teaches to treat adhesive substances which ensure a reliable hold of up to 8 hours-and more and which do not impair the removal of the denture in a manner providing a delaying action. Unlike the disadvantageous prior art prosthesis adhesives in which all the adhesive substances are simultaneously used in the active state, in the dental prosthesis adhesive according to the invention the release of the adhesion-imparting substances takes place in time-controlled manner, in that in part the adhesion-imparting substances are provided with a coating which slowly dissolves in the saliva and/or in ingestive liquids and when dissolved releases unoonswd adhesive and cones into action after the "consumption" or release or washing away of the already consumed adhesive. The adhesive substances can be chemically defined compounds, for example sodium carboxymethyl cellulose, Karaya gum, guar gum, tragacanth, polyethylene oxide polymers; copolymers of maleic anhydride with lower alkylvinylether and mixed partial salts thereof polyacrylamide and the like, mixtures thereof, natural substances or mixtures thereof or also mixtures with chemical substances. Optionally the denture adhesive composition may contain flavours, colorants, preservatives, fillers and other common denture adhesive additives. The dental prosthesis adhesive according to the invention is produced by coating part of the adhesive substances with a varyingly thick protective film, and saliva or ingested liquids successively release the adhesive by dissolving the coating. The coating on the adhesive particles can be formed by the most varied substances such as e.g. ethyl cellulose, saccarose monostearate, gum arabic, cellulose acetate phthalate, acrylates, methycrylate, shellac- and other film-formers. The coating agent, which is e.g. used as a film, can be formed by substances which are insoluble or sparingly soluble in water, their sparing solubility only occurring within specific pH-ranges. Conventionally, between approximately 10 and 90% of the adhesive substances are coated, coating taking place e.g. by spraying adhesive substance particles with the film former dissolved in a solvent. Conventionally, between approximately 10 and 90% of the adhesive substances used are coated and initially the uncoated portion brings about the adhesion of the prosthesis. After washing out this uncoated portion, the remaining adhesive is slowly released after a time which can be predetermined by the choice of coating the thickness thereof, so that a much longer overall adhesive period can be achieved than would be possible with the uncoated adhesive. As a result of the process according to the invention, the conventional adhesion time can be extended by several additional hours. However, no difficulties are encountered if it is possibly necessary in the meantime to remove the prosthesis, because the adhesion of the adhesive is always the same as with normal adhesives being effective for shorter periods. In addition, no difficulties are encountered in cleaning the prosthesis because the conventional, easily removable prosthesis adhesives can be used. Further features and advantages of the invention can be gathered from the claims and the following description of performance examples. Example 1 Preparation of adhesive powder 150 kg sodium carboxymethyl cellulose (particle size max. 0.6 mm) are sprayed in a fluidized bed procedure (fluidized bed drier like AEROMATIC or GLATT) with 120 kg of a 6.5% methacrylate isopropanol solution, resulting in a coating with a thickness of 2 - 5 micrometer. Spraying and drying are conducted in one step according to the conventional fluidized bed procedure. The yield is about 160 kg sodium carboxymethyl cellulose coated by a film. 40 parts by weight of the coated sodium carboxymethyl cellulose are well mixed with 60 parts by weight of non coated sodium carboxymethyl cellulose. The resulting pulverulent mixture can be used as an adhesive powder for dental prosthesis with a considerabLy longer adhesion period than conventional similar adhesives. Example 2 Preparation of a semifluid dental prosthesis adhesive An adhesive powder prepared in the manner described in example 1 is incorporated into a semifluid carrier constituted by a mixture of paraffin and glycol or polyethyleneglycol and glycerol. The resulting highly viscous liquid imparts good adhesion to a dental prosthesis for a longer period than the conventional similar adhesives. Example 3 Preparation of a prosthesis adhesive powder 150 kg sodium carboxylmethyl cellulose (particle size max. 0.6 mm) are sprayed in a fluidized bed procedure (fluidized bed drier like AEROMATIC or GLATT) with 60 kg of a 6.5% ethylalcoholic ethylcellulose solution, resulting in a coating with a thickness of 2 - 5 micrometer. Spraying and drying are conducted in one step according to the conventional fluidized bed procedure. The yield is about 160 kg NaCMC, the particles thereof being coated with an ethylcellulose film. 50 parts by weight of the coated NaCMC (sodium carboxymethyl cellulose) are well mixed with 50 parts by weight of uncoated sodium carboxymethyl cellulose. The resultant powder can be used as an adhesive powder for dental prosthesis having a longer effective period than conventional similar adhesives. Example 4 Preparation of a dental prosthesis cream The adhesive powder mixture described in example 3 is incorporated into a creamy carrier formed from petrolatum and liquid petrolatum and paraffin oil. The adhesive cream provides a satisfactory adhesive action for a longer period, when applied to a dental prosthesis,' than conventional similar adhesives. Further, suitable flavorants, such as peppermint oi, or the like can be added to the denture adhesive compositions to improve the taste.

Claims: Claims 1. Dental prosthesis adhesive formed from one or more adhesive substances, characterized in that at least a part of the adhesive substance or substances are provided with a coating which dissolves slowly in saliva. 2. Dental prothesis adhesive according to claim 1, characterized in that the coating for the adhesive substance contains one or more substances selected from the group consisting of ethyl cellulose, saccarose monostearate, gum arabis, cellulose acetate phthalate, acrylate, methacylate, shellac or other film providing substances. 3. Dental prothesis adhesive according to either of the claims 1 and 2, characterized in that the adhesive substance at least partly contains sodium carboxymethyl celllulose. 4. Dental prothesis adhesive according to one of the preceding claims, characterized in that the coating is sparingly soluble in water. 5. Dental prosthesis adhesive according to one of the claims 1 to 3, characterized in that the coating is insoluble in water. 6. Dental prosthesis adhesive according to one of the claims 1 to 3, characterized in that the coating is soluble at a pH-value from 3,5 to 9,0. 7. Dental prosthesis adhesive according to one of the preceding claims, characterized in that 10 to 90% of the adhesive substance used is coated. 8. Dental prosthesis adhesive according to claim 1, characterized in that sodium carboxymethyl cellulose coated with ethyl cellulose is used as the coated adhesive substance. 9. Dental prosthesis adhesive according to claim 8, characterized in that 50% coated sodium carboxymethyl cellulose is used as the adhesive substance. 10. Dental prosthesis adhesive according to one of the preceding claims, characterized in that the at least partly coated adhesive substance or substances are embedded in a creamy carrier substance. 11. Dental prosthesis adhesive according to claim 10, characterized in that the creamy carrier substance contains petrolatum and liquid petrolatum and paraffin oil 12. Dental prosthesis adhesive according to one of the claims 1 to 9, characterized in that the at least partly coated adhesive substance or substances are embedded in a semifluid carrier substance. 13. Dental prosthesis adhesive according to claim 12, characterized in that the semifuid carrier substance is a micture of paraffin and glycerol or polyethylene glycol and glycerol. 14. Process for the preparation of a dental prosthesis adhesive, characterized by coating adhesive substance or substances with a coating which is slowly soluble in the saliva and mixing the coated adhesive substance or substances with uncoated adhesive substance or substances. 15. Process according to claim 14, characterized in that the mixture is prepared from 90% to 10% of coated adhesive substance and 90 to 10% of noncoated adhesive substance. 16. Process according to claim 15, characterized in that the mixture is embedded in a carrier. 17. Process according to claim 16, characterized in that the carrier is semifluid. 18. Process according to claim 17, characterized in that the semifluid carrier is a mixture of paraffin and glycerol and polyethylen glycol and glycerol. 19. Process according to claim 17, characterized in that the carrier is creamy. 20. Process according to claim 19, characterized in that the creamy carrier is a mixture of vaseline and paraffin oil. 21. Process according to one of the claims 14 to 20, characterized by coating sodium carboxymethyl-cellulose particles with a methacrylate alcohol solution and mixing the coated sodium carboxymethyl cellulose particles with uncoated sodium carboxymethyl cellu lose particles. 22. Process according to one of the claims 14 to 20, characterized by coating sodium carboxymethyl cellulose particles with an ethyl cellulose solution and mixing the coated sodium carboxymethyl cellulose particles with uncoated sodium carboxymethyl cellulose particles.

Inventors: WIENECKE, HORST, DR.
Applicants: RICHARDSON GMBH
Application year: 1981
Main classification: A61K6
IPC codes: A61K6, A61C13