AMINOTHIADIAZOLES AS GASTRIC SECRETION INHIBITORS

Abstract: There are disclosed novel compounds described as 3,4-diamino 1,2,5-thiadiazoles wherein one of the amine functions is connected to a substituted or unsubstituted phenyl or heterocyclic group through a linear connecting group or through a phenylene connecting group. Proces­ ses are provided for the preparation of such compounds from amino precursors. The compounds are useful for the suppression of gastric acid secretions in mammals and compositions for such uses are also disclosed.

Description: TITLE OF THE INVENTION Aminothiadiazoles as Gastric Secretion Inhibitors BACKGROUND OF THE INVENTION Inhibitors of gastric acid secretion functioning by antagonism of the histamine H2-receptor are effective antiulcer agents. Structurally, such compounds are typically viewed as molecules having three substituents or fragments; i.e., A-B-C, each of which can independently affect the antisecretory activity. The "A" portion may be a substituted or unsubstituted aromatic or heteroaromatic group such as are disclosed in, for example, U.S. Patent 3,950,333 to Durant et al, U.S. Patent 4,128,658 to Price et al and Belgian Patent 867,106 (Derwent Abstract 84065A/47). The central, or "B" portion, may be a connecting chain joined to A such as A-CH2SCH2CH2-, AOCH2CH2CH2, or A-(mphenylene)- as disclosed in the aforementioned patents as well as in European Patent 3,640-to Jones et al (Derwent Abstract 61827 B/34). The remaining terminal substituent "C" is structurally distinct from either the A and B portions and may be, for example, a substituted guanidine, a substituted l,l-diamino ethylene, or a 3,5-diamino-l-alkyl triazole as disclosed in the aforementioned U.S. Patents to Durant et al and Price et al as well as in Belgian Patent 875,846 (Derwent Abstract 79110 B/44). The present invention is directed to unique "C" moieties which confer antisecretory activity when combined with the A-B molecular fragments comprising these antiulcer agents. These novel, structural "C" elements are the 3,4-diamino-l,2,5-thiadiazole- l-oxide and the 3,4-diamino-l,2,5-thiadiazole-l,l- dioxide groups. Incorporation of these groups into the A-B molecular fragments affords compounds that exhibit significantly greater activity than known prior art compounds, including those disclosed in the U.S., Belgian and European Patents identified above. SUMMARY OF THE INVENTION This invention is concerned with 3,4-diamino1,2,5-thiadiazole compounds which have one of the amino groups connected to a substituted or unsubstituted phenyl or heterocyclic moiety through a linear or cyclic connecting group. Thus, it is an object of this invention to describe such compounds. It is a further object of this invention to describe processes for the preparation of such compounds from the appropriately substituted amine and thiadiazole precursors. A still further object is to describe the use of such compounds as gastric secretion inhibitors in mammals. Further objects will become apparent from a reading of the following description. DESCRIPTION OF THE INVENTION The compounds of this invention are best realized in the following structural formulae: EMI3.1 wherein in both of the above structural formulae: R is hydrogen, loweralkyl, EMI4.1 wherein R3 and R4 are independently hydrogen, loweralkyl, cycloloweralkyl or phenlloweralkyl or R3 and R4 may be joined to form, along with the nitrogen to which they are attached, a 5- or 6-membered heterocycle, which may also contain an oxygen, sulfur or an N-R7 heteroatom, selected from pyrrolidino, piperidino, thiomorpholino, morpholino, or N-loweralkylpiperazino wherein R7 is hydrogen or loweralkyl of from 1 to 3 carbon atoms; R5 and R6 are independently hydrogen or loweralkyl; n is O or 1; m is 2 to 4; k is 1 to 4; X is oxygen, sulfur or methylene; p is 1 or 2; ; R1 and R2 are independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, cycloloweralkyl, phenyl, pyridyl, or substituted loweralkyl wherein the substituent is phenyl, cycloloweralkyl, pyridyl, imidazolyl, morpholino, hydroxy, loweralkoxy, loweralkylthio or di(loweralkyl)amino, and R1 and R2 may be joined to form along with the nitrogen to which they are attached a 5- or 6-membered heterocycle which may also contain an oxygen, sulfur or an N-R7 heteroatom selected from pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, or N-loweralkyl piperazino, wherein R7 is a as defined above. is is phenylene or a 5- or 6-membered heterocycle containing one to three heteroatoms selected from oxygen, sulfur or nitrogen, which may optionally have a benzo ring fused thereon; provided that when # in Formula I above is a 5-membered heterocycle or a benzo fused 5-membered heterocycle, n is 1; and, provided further that when # in either Formula I or II is a furan having the structure EMI5.1 then R8 is the same as R defined above and R9 is loweralkyl, alkoxyalkyl, alkoxycarbonyl, halo, preferably chlorine or bromine, or aryl, preferably phenyl. in in the foregoing formulae may be furan, thiophene, pyrrole, oxazole, oxadiazole, thiadiazole, thiazole, triazole, pyrazole, imidazole, pyridine, pyrimidine, pyrazine, and the like and the fused benzo derivatives thereof such as benzofuran, benzoxazole, benzimidazole, and the like. The compounds of this invention also include derivatives of Formula I having the structural formulae: EMI6.1 (IIIB) wherein R, R1, X, m, n and p are as defined above, and R10 is - (CH2)yCOR11 wherein y is 1 or 2 and R11 is lower alkyl, hydroxy, alkoxy, amino, loweralkylamino, or diloweralkylamino. Compounds IIIA and IIIB are prepared by reacting compounds of Formula I or tautomers thereof with alkylating agents such as, for example, a-haloketones, aldehydes, acids, esters, or amides; or, a,ss-unsaturated aldehydes, acids, esters, or amides by alkylation processes known to those skilled in the art. Further derivatives in which R10 in compounds of Formulae IIIA and IIIB can be lower alkanoyl, aroyl, substituted aroyl, hetaroyl, lower alkylsulfonyl, arylsulfonyl, hetarylsulfonyl, cyano, amidino; i.e., EMI7.1 dialkyl carbamoyl; i.e., EMI7.2 dialkylsulfamoyl; i.e., EMI7.3 or alkoxycarbonyl can be obtained by reacting compounds of Formula I with acyl halides, acyl anhydrides, sulfonyl halides, cyanogen halides, S-alkylisothioureas, carbamoyl halides, sulfamoyl halides, or haloformates, and the like. In these reactions, mixtures of compounds IIIA and IIIB are obtained which can be separated by conventional means such as, for example, chromatography and fractional crystallization. Also included within the scope of the present invention are compounds having the structural formulae: EMI7.4 wherein R, R5, (A, , X, m, n and p are as defined above and R12 is aralkylidene or diarylmethlidene. Compounds IVA are prepared by reacing intermediate compound VI (defined hereinafter) with EMI8.1 or (aryl)2C=NH. Compounds IVB are prepared by reacting intermediate compound VI (defined hereinafter) with EMI8.2 In the instant invention, unless specified otherwise, the term "loweralkyl" is intended to include those alkyl groups containing from 1 to 5 carbon atoms in either a straight or branched configuration. Examples of such alkyl groups are methyl, ethyl, propyl, iso-propyl, butyl, sec-butyl, pentyl and the like. The term "cycloloweralkyl" is intended to include those cycloalkyl groups of from 3 to 7 carbon atoms. Examples of such cycloalkyl groups are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and cycloheptyl. The term "loweralkenyl" is intended to include those alkenyl groups of from 3 to 5 carbon atoms of either a straight or branched configuration and one unsaturation. Examples of such alkyl groups are propenyl, butenyl, pentenyl, and the like. The terms "hetaroyl" and "hetarylsulfonyl" are intended to include those compounds derived from six membered N-containing rings having one or two heteroatoms. The term "substituted aroyl" is intended to include phenyl substituted with one to three substituents selected from halo, alkyl, and alkoxy. The term "loweralkynyl" is intended to include those alkynyl groups of from 3 to 5 carbon atoms of either a straight or branched configuration, and one triple bond. Examples of such alkynyl groups are propargyl, butynyl, pentynyl, and the like. The terms "alkoxyalkyl", ',hydroxyalkyl" and "alkoxycarbonyl" are intended to include those normal and branched alkyl groups containing from 1 to 5 carbon atoms. Thus, the term "alkoxyalkyl" is exemplified by such compounds as methoxymethyl, ethoxy methyl, methoxy propyl, methoxy butyl, and the like; the term "hydroxyalkyl" is exemplified by such compounds as hydroxy methyl, hydroxy ethyl, hydroxypropyl, hydroxybutyl, and the like; and, the term "alkoxycarbonyl" is exemplified by such compounds as methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl, and the like. The preferred compounds of the instant invention will have definitions which vary with the nature of the compounds of Formula I and II. In Formula I preferred compounds are realized when R1 and R2 are independently hydrogen, loweralkyl, loweralkynyl or substituted loweralkyl wherein the substituent is phenyl, pyridyl or imidazolyl; and R3 and R4 are independently hydrogen, loweralkyl or R3 and R4 are joined to form a piperidine, morpholine or N-loweralkyl piperazine heterocyclic ring. Further preferred compounds are realized when R1 and R2 are independently hydrogen or loweralkyl and P is 1 or 2. Further such preferred compounds are those wherein Hz is m-phenylene.or a 6-membered heterocycle as defined above, n is O, X is oxygen, m is 3 and R is: EMI11.1 In such cases it is further preferred that k be 1 and R3 and R4 be loweralkyl, preferably methyl, or joined to form a morpholine, piperidine or N-methyl piperazine ring. Additional preferred variation of # are those wherein # is furan, imidazole, thiazole, oxazole, thiophene, triazole, thiadiazole, oxadiazole or benzofuran. When # is heterocyclic it is preferred that n=l, X=sulfur and m=2. The preferred values of R will depend upon and vary with the definition of. When is furan or benzofuran, R is preferred to be: EMI11.2 wherein it is further preferred that k=l and R3 and Rbe hydrogen or loweralkyl, preferably hydrogen or methyl, or joined to form a morpholine, piperidine or N-methyl piperazine ring. When # is imidazole R is preferably loweralkyl, most preferably methyl. When Hz is thiazole, R is preferably: EMI12.1 where R5 and R6 are most preferably hydrogen. In Formula II it is preferred that R1 and R2 are independently hydrogen or loweralkyl and p is 1 or 2. It is further preferred that the phenyl ring in Formula II be connected to the adjacent groups at its meta positions. As in Formula I compounds the preferred values of R in Formula II compounds will vary with the nature of # , The preferred values of # are imidazole, and thiazole. When # is imidazole, it is preferred that R be loweralkyl, most preferably methyl. When # is thiazole, it is preferred that R be: EMI12.2 and wherein it is most preferred that R5 and R6 be hydrogen. Specific examples of the preferred compounds of this invention are: 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio]- ethyl]amino-4-methylamino-1,2,5-thiadiazole-1-oxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio]- ethyl]amino-4-methylamino-1,2,5-thiadiazole-1,1- dioxide 3-N-[2-[(2-furanyl)methylthio]ethyl]amino-4-amino- 1,2,5-thiadiazole-l-oxide 3-N-[2-[(2-guanidino-4-thiazolyl)methylt amino-4-methylamino-l,2,5-thiadiazole-l-oxide 3-N-[ 2-[(5-dimethylaminomethyl-2-furanyl)methylthiol- ethylamino] -4-dimethylamino-l,2,5-thiadiazole-l- oxide 3-N-[3-(2-guanidino-4-thiazolyl)phenyl]amino-4-methyl- amino-1,2,5-thiadiazole-l-oxide 3-N-[3-(2-guanidino-4-thiazolyl)phenyl]amino-4-methyl- amino-1,2,5-thiadiazole-l,l-dioxide 3-N- [2- [5-dimethylaminomethyl-2-furanyl) methylthio] ethyl]amino-4-(2-propynyl)amino-1,2,5-thiadiazole- l-oxide 3-N- [2-[(5-dimethylaminomethyl-2-furanyl)methylthio3 ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N- [2-[(2-guanidino-4-thiazolyl)-methylthio]ethyl]- amino-4-methylamino-l,2,5-thiadiazole-l,l-dioxide 3-N-[3- [3-(dimethylaminomethyl)phenoxy]propyl3amino-4- amino-1,2,5-thiadiazole-l-oxide 3 -N-[ 2-[[3-(dimethylaminomethyl)phenyl]methylthio]- ethyl] amino-4-amino-1,2,5-thiadiazole-l-oxide 3-N- E 3-[3- (dimethylaminomethyl)phenoxy]propyl]amino-4- methylamino-1,2,5-thiadiazole-l-oxide 3-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino-4- methylamino-1,2,5-thiadiazole-l-oxide 3-N-[3-[3-[( 4-methyl-1-piperazinyl)methyl]phenoxy]- propyl]amino-4-methylamino-1,2,5-thiadiazole-1- oxide 3-N-[3-[3- (4-morpholinomethyl)phenoxy]propyl]amino- 4-methylamino-1,2,5-thiadiazole-l-oxide 3-N-[3-[3- (4-morpholinomethyl)phenoxy]propyl]amino- 4-amino-1,2,5-thiadiazole-l-oxide 3-N-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]amino- 4-methylamino-1;2,5-thiadiazole-l-oxide 3-N- [2-[(4-methyl-5-imidazolyl)methylthio]ethylIamino- 4-amino-1;2,5-thiadiazole-l-oxide 3-N- [2-[[5-(1-piperidinylmethyl)-2-furanyl]methylthio3- ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N- [2- [[5- (4-morpholinylmethyl) -2-furanyl]methylthio] - ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N-[3-[3- (dimethylaminomethyl)phenoxy3propyl]amino- 4-amino-1; ;2,5-thiazole-l-oxide 3-N-[3-[3- (1-piperidinylmethyl)phenoxy]propyl3amino- 4-amino-1,2,5-thiadiazole-l-oxide 3-N-[3-[3- (4-morpholinylmethyl)phenoxy]propyl]amino- 4-amino-1,2,5-thiadiazole-1-oxide 3-N-[2-[[6-(4-morpholinylmethyl)-2-benzofuranyl]methyl- thio]ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N-[ 2-[(2-guanidino-4-thiazolyl)methylthio]ethyl]- amino-4-amino-l , 2, 5-thiadiazole-l-oxide 3-N-[3-( 2-guanidino-4-thiazolyl)phenyl]amino-4-amino- 1,2,5-thiadiazole-1-oxide 3-N- [2-[(5-dimethylaminomethyl-2-furanyl)methylthio] ethyl] amino-4-amino-l,2,5-thiadiazole-l,l- dioxide 3-N- [3-f3-(dimethylaminomethyl)phenoxy]propyl]amino- 4-amino-1,2,5-thiadiazole-1,1-dioxide 3-N-[2-[[6-(4-morpholinyl-2-benzofuranyl]methylthio]- ethyl]amino-4-amino-1,2,5-thiadiazole-1,1-dioxide 3-N-[3- (2-guanidino-4-thiazolyl)phenyl]amino-4-amino 1,2,5-thiadiazole-1,1-dioxide 3-N-[2-[[6-(4-morpholinyl)-2-benzofuranyl]methylthio]- ethyl3amino-4-methylamino-1,2,5-thiadiazole-1- oxide 3-N-[3-[3-(dimethylaminomethyl)phenoxy]propyl]-amino- 4-methylamino-1-,2,5-thiadiazole-1,1-dioxide <RTI ID=15.2> 3-N-[2-[(2-guanidino-4-thiazolyl)methylthio]ethyl]- amino-4-cyclohexylamino-1,2,5-thiadiazole-1-oxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio]- ethyl]amino-4-phenylamino-1,2,5-thiadiazole-1,1- dioxide 3-N-[2-rt6-(4-morpholinyl)-2-benzofuranyl]methylthio]- ethyl]amino-4-(2-pyridylamino) -1,2,5-thiadiazole- l-oxide 3-N-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]amino- 4-phenethylamino-l, 2, 5-thiadiazole-l-oxide 3-N-[3-[3-(4-morpholinylmethyl)phenoxy]propyl]amino-4- cyclohexylmethylamino-1,2,5-thiadiazole-1,1-dioxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio]- ethyl]amino-4-[(2-pyridylmethyl)amino]-1,2,5- thiadiazole-l,l-dioxide 3-N-[3-[3-(dimethylaminomethyl)phenoxy]propyl]amino-4- [2-(3-pyridyl)ethyl]amino-1,2,5-thiadiazole-1- oxide 3-N-[3-(2-guanidino-4-thiazolyl)phenyl]amino-4-[2(1- imidazolyl)ethyl]amino-1,2,5-thiadiazole-1,1- dioxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio]- ethylamino-4- (2-methoxyethyl) amino-l, 2,5- thiadiazole-l-oxide 3-N-[2[(2-guanidino-4-thiazolyl)methylthio]ethyl]amino -4-dimethylaminoethyl-1,2,5-thiadiazole-1,1-dioxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl]methyl]amino ethyl]amino-4-(1-piperidino)-1,2,5-thiadiazole l-oxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthiol- ethyl]amino-4-ethoxy-1,2,5-thiadiazole-1-oxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio]- ethyl]amino-4-ethoxy-1,2,5-thiadiazole-1,1- dioxide 3-N-[3-[(5-dimethylaminoethyl-2-furanyl)methylthio3- propyl]amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N-[4-[(5-dimethylaminoethyl-2-furanyl)-methylthio- butyl3amino-4-methylamino-1,2,5-thiadiazole-1,1- dioxide 3-N-[3-[3-(dimethylaminomethyl)phenylthio]propyl]- amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N-[2-[3-(4-morpholinylmethylphenyl)methylthio]- ethyl]amino-4-methylamino-1,2,5-thiadiazole-1- oxide 3-N-[4-(3-dimethylaminophenyl)butyl]amino-4-methylamino -1,2,5-thiadiazole-l-oxide 3-N-[2-[[5-(2-N-methylaminoethyl)-2-thienyl]methyl- thio]ethyl]amino-4-amino-1,2,5-thiadiazole-1- oxide 3-N-[3-(6-morpholinylmethyl-2-pyridinyloxy)propyl]- amino-4-amino-1,2,5-thiadiazole-l-oxide 3-N-[2-[[5-(2-methylguanidino)-1,2,4-thiadiazol-3-yl]- methylthio]ethyl]amino-4-amino-1,2,5-thiadiazole-1, dioxide 3-N-[2-[(5-guanidino-1,2,4-oxadiazol-3-yl)methylthio]- ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N-[2-[[6-(dimethylaminomethyl)-2-pyrazinyl]methyl- thio]ethyl]amino-4-amino-1,2,5-thiadiazole-1,1- dioxide 3-N-t2-[(5-methyl-4-oxazolyl)methylthio]ethyl]amino- 4-amino-1,2,5-thiadiazole-l-oxide 3-N-[2-[6-(dimethylaminomethyl)-2-benzo[b]thienyl- methylthio]ethyl]amino-4-amino-1,2,5-thiadiazole- l,l-dioxide 3-N-[3-[5-(N-ethylamino)methyl-3-pyridyloxy]propyl]- amino-4-amino-l, 2, 5-thiadiazole-1-oxide The compounds according to the invention readily form physiologically acceptable salts. Such salts include salts with inorganic acids such as hydrochlorides, hydrobromides, sulfates, nitrates and phosphates. Particularly useful salts of organic acids are formed with aliphatic mono- or dicarboxylic or sulfonic acids. Examples of such salts are acetates, maleates fumarates, tartrates, citrates, benzoates, succinates, methane sulfonates, and isethionates. The compounds and their salts may also form hydrates and solvates. In addition, the nitrogen atoms in groups R, Hz R1 and R2 may also form quaternary salts and N-oxides. It will also be appreciated by those skilled in the art that the compounds of this invention will have a tautomeric isomerism about the nitrogen atoms adjacent to the thiadiazole ring. Where one or both of the adjacent nitrogen atoms has a hydrogen atom thereon, the exo-imino structure may be formed on one or both of such nitrogen atoms as shown in the following structure: EMI17.1 All of the various tautomeric structures of the instant compounds are intended to be included in this invention. In addition, when R is guanldino, three tautomeric structure variations are possible, and all such tautomers are included in this invention. In addition, when p is 1, there exists¯ the possibility of stereoisomerism in the instant compounds, corresponding to an R or S absolute configuration at the sulfur atom of the thiadiazole ring. It is intended that all such stereoisomers are included within the instant invention. As stated above, the compounds represented by Formulae I, II, III, and IV-have been found to have pharmacological activity in the animal-body as antagonists to certain actions of histamine which are not blocked by "antihistamines" such as mepyramine. For example, they have been found to inhibit selectively the histamine-stimulated secretion of gastric acid in the stomach of chronic fistula dogs at doses of from 0.001 to 5 mg per kilogram intravenously or orally from 0.01 to 10 mg per kilogram. Similarly, the action of these compounds is demonstrated by their antagonism to the effects of histamine on other tissues which are not affected by histamine H1 antagonists. An example of such tissue is the isolated guinea-pig right atrium. These compounds have been found to be up to 200 times more active in animal models than currently marketed gastric antisecretory H2 antihistamines. The pharmaceutical carrier employed may be for example, either a solid or liquid. Exemplary of solid carriers are lactose, terra alba, sucrose, talc, gelatin, agar, pectin, acacia, magnesium stearate, stearic acid and the like. Exemplary of liquid carriers are syrup, peanut oil, olive oil, water and the like. A wide variety of pharmaceutical forms can be employed. Thus, if a solid carrier is used, the preparation can be tableted, placed in a hard gelatin capsule in powder or pellet form, or in the form of a troche or lozenge. The amount of solid carrier will vary widely but preferably will be from about 15 mg to about 0.4 gm. If a liquid carrier is used, the preparation may be in the form of a syrup, emulsion, soft gelatin capsule, sterile injectable liquid such as an ampoule, or an aqueous of nonaqueous liquid suspension. The pharmaceutical compositions are prepared by conventional techniques involving procedures such as mixing, granulating and compressing or dissolving the ingredients as appropriate to the desired preparation. The active ingredient will be present in the composition in an effective amount to inhibit histamine gastric acid secretory activity. The route of administration may be orally or parenterally. Preferably, each daily dosage will contain the active ingredient in an amount of from about 1 mg to about 500 mg, most preferably from about 20 mg to about 200 mg given in a single dose or multiple divided doses. For therapeutic use, the pharmacologically active compounds of the present invention will normally be administered as a pharmaceutical composition comprising as the or an essential active ingredient at least one such compound in the basic. form or in the form of an addition salt with a pharmaceutically acceptable acid and in association with a pharmaceutical carrier therefor. Such addition salts include those mentioned above. Other pharmacologically active compounds may in certain cases be included in the composition. It may be appropriate to combine the instant compound or compounds with anticholinergic agents such as propantheline; H1 antihistamines such as mepyramine; pyribenzamine chlorpheniramine and the like; or prostanoids. Advantageously the composition will be made up in a dosage unit form appropriate to the desired mode of administration, for example as a tablet, capsule or injectable solution. The compounds of this invention are prepared by reacting a 1,2,5-thiadiazole-l-oxide or -l,l-dioxide substituted with the appropriate amino group and a leaving group, with an appropriately substituted amine. The reaction is outlined in the following reaction schemes wherein R, R1, R2-, 3, R4 R5 R6, R7 R8, Rg XI k, m, n, and p are as defined above, unless indicated otherwise, and L1 and L2 denote leaving groups: : REACTION SCHEME I EMI21.1 REACTION SCHEME II EMI22.1 REACTION SCHEME III EMI23.1 REACTION SCHEME IV EMI24.1 REACTION SCHEME V EMI25.1 REACTION SCHEME VI EMI26.1 REACTION SCHEME VII EMI27.1 The appropriate leaving groups for these reactions are exemplified by loweralkoxy, loweralkylthio, phenoxy, phenylthio and halogen.- Such loweralkoxy and loweralkylthio leaving groups are those such groups containing from 1 to 5 carbon atoms in either a straight or branched configuration. Examples of such groups are'methoxy, ethoxy, propoxy, iso-propoxy, butoxy, sec-butoxy, pentoxy, methylthio, ethylthio, propylthio, isopropylthio, phenoxy, phenylthio and the like. The term "halogen includes the halogen atoms chlorine, fluorine, and bromine. The preferred leaving groups are methoxy, ethoxy, methylthio, fluorine, chlorine and bromine. As is noticed in Reaction Schemes I and II, the diaminothiadiazole compounds are prepared by first displacing one of the leaving groups of Compound III with an amine, either the simple or the complex amine, followed by displacement of the other leaving group by the other amine to produce the desired compounds. This reaction is carried out on the thiadiazole sulfoxide or sulfone. In the first step of both Reaction Schemes I and II the reagents are combined in preferably an aprotic solvent, such as tetrahydrofuran, acetonitrile, ethylacetate, ether, and the like at from -78 to +500C, preferably from -78 to OOC; The process is a fast reaction and is completed quickly. Generally a gaseous amine is bubbled into the reaction mixture for sufficient time to complete the reaction, preferably 1 equivalent of the amine is added over a period of from 5 minutes to 2 hours. A solid or liquid amine is added in portions over the same period of time. The progress of the reaction may be followed by taking aliquots of the reaction mixture and analyzing them on thin layer chromatography plates. When the reaction is complete, the reaction mixture is allowed to warm and the product is recovered using techniques known to those skilled in the art. The reaction with the second amine is generally slower than with the first. The reactivity in each case is determined, however, by the particular thiadiazole substrate and the nature of the amine being reacted therewith. The reaction with the second amine is carried out in protic or non-protic solvent such as methanol, ethanol, ether, ethylacetate tetrahydrofuran and the like. The reaction is generally carried out at from OOC to 1000C and is complete in from 5 minutes to 6 days. If the desired reaction temperature is higher than the boiling point of the reaction mixture, the reaction may be carried out in a pressure vessel. Reactions with the thiadiazole sulfones are generally faster than those with the corresponding sulfoxide and as a result the reaction with sulfones are generally complete inshorter times and at lower temperatures than with the sulfoxides. The products are isolated using techniques known to those skilled in the art. An alternate procedure for the reaction of the first amine with the starting material (V) consists of reacting the trialkylsilyl derivative or the bis (trialkylsilyl) derivative of the amine with Compound V. The reaction may be used with either the complex or the more simple amine, however, it is preferably employed with the simpler, and thus more reactive amines, and ammonia. In the case of ammonia as a reactant to produce the compounds wherein R1 and R2 are hydrogen, the preferred reactant is hexamethylsilazane, a commercially available reagent. This reagent is reacted with Compound V in an aprotic solvent at about room temperature for from 1 to 24 hours. The silyl groups present on the intermediate product are removed by treating such intermediate with water or an alcohol, at about room temperature. When Compound V is to be reacted with an amine other than ammonia, the appropriate reagent is prepared by treating the amine hydrohalide, preferably hydrochloride with an excess of the reagent such as hexamethylsilazane. The reaction is carried out without any solvent from room temperature to 1000C for from 1/2 to 24 hours. The thus produced trialkyl silyl or bis (trialkyl silyl) amine is then reacted with Compound V as described above. Thesilyl group is also removed as described above and the product (VI, VI-A, or VII) is isolated using techniques known to those skilled in the art. As shown in Reaction Scheme III, the preferred compounds of this invention whereinis furan and k is 1 in I are alternatively prepared by a Mannich type reaction on the appropriate furan intermediate VIII (I, R=H). Compound VIII is allowed to react in an aqueous solution wth an amine salt such as the hydrohalide and formaldehyde under conventional conditions utilized for the Mannich reaction. Alternatively, VIII can be reacted with the equivalent methylene ammonium reagent, EMI31.1 (wherein "Hal" is chlorine, bromine or iodine), in anhydrous media such as THF or acetonitrile with heating to reflux for 5-60 minutes to give product I. An alternate process for preparing compounds of Formula I wherein X=S, m=2, is shown in Reaction Scheme IV. Key intermediate alcohols IX are synthesized by displacement of a leaving group from intermediate VII with ethanolamine. The alcohol function of Compound IX can be converted to a leaving group (such as L1) which can then be displaced by mercaptans X in the presence of a base to afford Compounds I. Another process for preparing compounds of Formula I is shown in Reaction Scheme V wherein X=S, m=2. Key intermediate alcohols XII are synthesized from alcohol XI and mercapto ethanol in the presence of an acid. Alcohols XII are then activated toward nucleophiles with phosphonium or similar reagents in the presence of diaminothiadiazole intermediates XIII forming Compounds I. A further process for preparing compounds of Formula I is shown in Reaction Scheme VI wherein X=S, m=2. Key intermediate mercaptans XIV are synthesized from cysteamine and thiadiazole intermediates VII. The mercaptans XIV are then condensed with alcohols XV in the presence of an acid to provide Compounds I. In Reaction Scheme VII there is shown still another process for obtaining compounds of Formula I wherein X=0, k=l, m 2 and n=0. Alkali metal (M) salts of 3-hydroxy benzaldehyde XVIII can be reacted with active esters XVII of alcohols XVI to give key intermediates XIX. Intermediates XIX can then be reduced in the presence of amine R3NHR4 to afford Compounds I. Various intermediate compounds such as, for example, VI and VI-A, prepared from the thiadiazole starting material in which one of the leaving groups has been replaced by the complex amine such as,--for example, 3-N-[2-[(5-dimethylaminomethyl- 2-furanyl)methylthio]ethyl]amino-4-ethoxy-1,2,5-thiadia zole- l-oxide and 3-N-[(5-dimethylaminomethyl2-furanyl) methylthio]ethyl]amino-4-ethoxy 1,2,5-thiadiazde- l,l-dioxide have substantialgastric secretion inhibitory activity. Thus, such intermediate compounds are deemed to constitute part of this invention. The thiadiazole starting materials wherein p=2 with two leaving groups thereon are compounds generally known in the art. For example see Ca-rmack et al J. Org. Chem. 30 2743 (1975). The complex amines which are reacted with the thiadiazole starting material are also compounds known in the art. See for example the Durant et al, Price et al and Jones et al references discussed in the Background of the Invention. It will be of course realized that other amine starting materials, similar to those discussed in the foregoing references, may be prepared using the procedures described in such references. The thiadiazole starting materials wherein p is 1, with two leaving groups thereon are unknown compounds in the art. Such compounds are prepared by reacting an appropriately disubstituted oxalimidate or oxalthioimidate with thionyl chloride to prepare the thiadiazole compounds with two leaving groups. EMI33.1 wherein L1 and L2 are as defined above. The appropriately disubstituted oxalimidate or oxalthioimidate is reacted with thionyl chloride in the presence of a base to neutralize the hydrogen chloride liberated during the course of the reaction. The base may be any organic or inorganic base which does not react with any of the starting materials or products. Generally tertiary amines such as triethylamine and pyridine or inorganic bases such as alkali metal carbonates or bicarbonates are employed. The reactants are generally dissolved in a suitable solvent such as methylene chloride, chloroform, toluene, ether, tetrahydrofuran, acetonitrile and the like, or any other solvent which is non-reactive to the starting materials and products. The reaction is carried out at from -780C (dry-ice bath) to 100C or the reflux temperature of the reaction mixture. The reaction is preferably carried out at from 0 to room temperature and is then generally complete in from 1/2 to 10 hours The thionyl chloride is generally used in slight excess although greater amounts of the reagent are not detrimental. Thus, the intermediate compounds obtained from these novel thiadiazole starting materials are also novel when p is 1 and can be represented by the following formulae: EMI34.1 wherein a) R1 and R2 are the same and are loweralkoxy, loweralkylthio, phenoxy or phenylthio; or b) R1 and R2 are different and one of R1 or R2 is amino, or loweralkylamino and the: other is halo or loweralkylthio; or, c) R1 and R2 are different and one of R1 and R2 is as defined in a) above and the other is: EMI35.1 wherein R3 and R4 are independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, cycloloweralkyl, phenyl, pyridyl, or substituted loweralkyl wherein the substituent is phenyl cycloloweralkyl, pyridyl, imidazolyl, morpholino, hydroxy, loweralkoxy, lower alkylthio, di (loweralkyl)amino or R3 and R4 may be connected to form , along with the nitrogen to which they are attached, a 5- or 6-membered heterocyclic ring which may also contain an oxygen, sulfur or an N-R5 heteroatom selected from morpholine, thiomorpholine, piperidine, piperazine, N-loweralkyl piperazine, and pyrrolidine wherein R5 is hydrogen or loweralkyl of from 1 to 3 carbon atoms; and, EMI35.2 wherein R1, R2, R3 and R4 can each independently be hydrogen, alkyl, loweralkenyl, loweralkynyl, cycloloweralkyl, aryl, phenyl, pyridyl, or substituted loweralkyl wherein the substituent is amino, phenyl, substituted phenyl, cycloloweralkyl, pyridyl, loweralkoxy, imidazolyl, morpholino, hydroxy, di(loweralkyl)amino or R3 and R4 may be connected to form, along with the nitrogen to which they. are attached, a 5- or 6-membered heterocyclic ring which may also contain an oxygen, sulfur or an N-R5 heteroatom, said heterocyclic ring being a member selected from morpholine, thiomorpholine, pipefridWinew piperazine, N-loweralkyl piperazine, and pyrraLidine and wherein R5 is hydrogen or loweralkyl of from 1 to 3 carbon atoms. The following examples are provided in order that the invention might be more fully understood, but they are not to be construed as limitative of invention. Unless otherwise indicated, all temperatures are in degrees Celsius. EXAMPLE 1 3-N- [2- [ (5-Dimethylaminomethyl-2-furanyl) methylthiol- ethyl] amino-4-methylamino-l,2,5-thiadiazole-l-oxide - hydrochloride A. 3-Ethoxy-4-methylamino-1-,2,5-thiadiazole-1-oxide Anhydrous methylamine (7.7 g, 0.25 mol) is - dissolved in 100 ml of tetrahydrofuran with dry ice-acetone cooling. This cold solution is added dropwise with stirring to 3,4-diethoxy 1,2,5-thiadiazole-l-oxide in 250 ml of tetrahydrofuran at -150C over 1 1/2 hours. Stirring is continued for an additional hour at -i50C and the solvent is removed in vacuo. The beige solid residue is purified by chromatography on silica gel (100 g) using chloroform. The nearly white solid (39.6 g) melts at 91-920C. IR Stretching vibration=1095 cm 1 for S=O 13C NMR for thiadiazole-l-oxide carbons: {= 163.34, 157.36 B. 3-N-12-[(5-Dimethylaminomethyl-2-furanyl) methylthio] -ethyl] amino-4-methylamino-1,2,5-thia- diazole-l-oxide hydrochloride To a stirred solution of 1.75 g (10.0 mmol) of 3-ethoxy-4-methylamino-1,2,5-thiadiazole-1-oxide in 25 ml CH2C12 is added 2.14 g (10.0 mmol) of 2-[(5-dimethylaminomethyl-2-furanyl)methylthio]ethyl- amine. The mixture is stirred three days at room temperature under nitrogen and concentrated under vacuum. The residue is redissolved in the minimum amount of methylene chloride and the solution is chromatographed on a dry column of activity III alumina. Elution with 1-2% methanol-CH2C12 gives the free base of the title compound which is dissolved in 1 equivalent 1N aqueous hydrochloric acid and the solution is filtered through filter aid and the filtrate lyophilized. The residue is dissolved in a mixture of 4 parts tetrahydrofuran and 1 part absolute ethanol and cooled to give a hygroscopic white solid which is filtered and dried in vacuo at 600C to give 3-N-[2-[(5-dimethyl aminomethyl-2-furanyl) methylthio] ethyl] amino-4-methyl- amino-1,2,5-thiadiazole-l-oxide hydrochloride as the tetrahydrofuran solvate (amorphous). The sample exhibits the correct nuclear magnetic resonance spectrum (D2O) and has an infrared stretching vibration of (KBr) of 1050 cm 1 for S=0. EXAMPLE 2 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methylthio]- ethyl3amino-4-methylamino-1,2,5-thiadiazole'l,l- dioxide hydrochloride A. 3-Ethoxy-4-methylamino-1,2,5-thiadiazole-1,1- dioxide To a solution of 2;06 g (10.0 mmol) of 3,4 diethoxy-l,2,5-thiadiazole-l,1-dioxide in 25 ml of acacetonitrile is added 0.8 g of a 40% solution of methylamine in water. The resulting clear colorless solution is aged at room temperature for 16 hours and concentrated under vacuum. The residue is stirred with 25 ml of methylene chloride and the mixture is filtered to give 0.35 g of a mixture of the title compound and 3,4-bis-methylamino-1,2,5-thiadiazole- l,l-dioxide. The filtrate is chromatographed. on activity III alumina and the title compound eluted with 29% methanol methylene chloride to give 0.65 g (34%) of pure 3-ethoxy-4-methylamino-1;2,5- thiadiazole-l,l-dioxide, m.p. 160-161 . B. 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methyl- thio]ethyl]amino-4-methylamino-l-2f5-thiadiazole-1 dioxide hydrochloride hydrate To a stirred suspension of 3-ethoxy 4-methylamino-l,2,5-thiadiazole-1,l-dioxide at.65 g, 3.4 mmol) in 10 ml of methylene chloride is added 0.73 g (3.4 mmol) of 2-[(5-dimethylaminomethy-l-2- furanyl) methylthiolethylamine. The suspension is stirred under nitrogen at room temperature and; becomes clear after 2.5 hours. After 1.5 days the mixture is concentrated under vacuum and the residue chromatographed on activity III alumina as in Example 2A. The free base of the title compound is dissolvedin 1 equivalent of 1N hydrochloric acid and the solution is filtered through filter aid and lyophilized to give 3-N-[2-[(5-dimethylaminomethyl 2-furanyl)methylthio]ethyl]amino-4-methylamino-1,2,5- thiadiazole 1, dioxide hydrochloride as the hydrate which is dried in vacuo at 600C (amorphous). The hygroscopic solid exhibits the correct nuclear magnetic resonance spectrum (D2O) and has an infrared stretching vibration (KBr) of 1155 and 1305 cm 1 for SO2. EXAMPLE 3 3-N-[2-[(2-Guanidino-4-thiazolyl)methylthio]ethyl]- amino-4-methylamino-l, 2, 5-thiadiazole-l-oxide To a stirred solution of 3.3 g (14 mmol) of 2-[(2-guanidino-4-thiazolyl)methylthio]ethyl amine in 25 ml of ethylacetate and 5 ml of absolute ethanol is added 2.5 g (14 mmol) 3-ethoxy-4-methylamino-1,2,5thiadiazole-l-oxide. The resulting suspension is stirred for 16 hours at room temperature under nitrogen during which the gum gradually solidifies to a white solid which is collected by filtration to give 5.1 g (100%) of crude title compound. Recrystallization from water containing a little methanol gives a white solid, m.p. 169-1710C (dec) identified as 3-N-[2-[(2-guanidino-4-thiazolyl) methylthio]ethyl]amino-4-methylamino-1,2,5-thiadiazole- l-oxide which exhibits the correct nuclear magnetic resonance spectrum (D2O,DC1) and an infrared stretching vibration (KBr) of 1030 cm 1 for SiO. EXAMPLE 4 3-N-[2-[(-Dimethylaminomethyl-2-furanyl)methylthio]- ethyl]amino-4-dimethylamino-1,2,5-thiadiazole-1-oxide A. 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl) methylthio]-ethyl]amino-4-ethoxy-1,2,5-thiadiazole-1- oxide 3,4-Diethoxy-1,2,5-thiadiazole-l-oxide (1.9 g, 10 mmol) is dissolved in 10 ml of tetrahydrofuran and a solution of 2-[(5-dimethylaminomethyl-2-furanyl) methylthio]ethylamine (2.14 g, 10 mmol) in 10 ml of tetrahydrofuran is added dropwise with stirring at ice bath temperature. The solution is stirred at room temperature overnight. Removal of the solvent in vacuo gives a viscous amber oil. Chromatography on silica gel (50 g) using 5% ethanol in chloroform gives 3.6 g of 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio ethyl]amino-4-ethoxy-1-,2,5-thiadiazole-1-oxide as a, viscous oil. Analysis and 1H nuclear magnetic resonance confirm the presence of 1/2 mole of chloroform. B. 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methyl- thio]-ethyllamino-4-dimethylamino-1,2,5-thiadiazole-1- oxide 3-N-[2-[(5-dimethylaminomethyl-2-furanyl methylthio]ethyl]amino-4-e-thoxy-1,2,5-thiadiazole-1- oxide (3.05 g, 8.5 mmol) is dissolved in l0 ml of; tetrahydrofuran and dimethylamine (0.38 g, 8.5 mmo,l) is bubbled into the solution at ice bath temperature. The reaction is stirred in a sealed flask at room temperature overnight. An excess of dimethylamine is then added to force the reaction to completion. Removal of the solvent in vacuo gives 2.7 g of viscous amber oil which is purified by chromatography on silica gel. The chromatographed oil solidifies to a pale beige solid upon extended standing and trituration in petroleum ether, m.p. 55-580C. It recrystallizes from n-butyl chloride affording 3-N-[2[(5-dimethylaminomethyl-2-furanyl)methylthiol ethyl]amino-4-dimethylamino-1,2-5-thiadiazole-1-oxide. EXAMPLE 5 3-N- [3- (2-Guanidino-4-thiazolyl) phenyl] amino-4-methyl- amino-1,2,5-thiadiazole-l-oxide A. 3-N-[3-(2-Guanidino-4-thiazolyl)phenyl]amino-4- methoxy-1, 2, 5-thiadiazole-l-oxide A solution of 2.33 g (0.010 mol) of 3-(2guanidino-4-thiazolyl)benzeneamine in 50 ml of methanol is added to a suspension of 1.94 g (0.010 mol) of 3, 4-bis (methylthio) -1,2, 5-thiadiazole-l-oxide in 20 ml of methanol with stirring. All solids dissolve and the solution is stirred for 120 hours. No change in the reaction mixture is noted by thin layer chromatography during the last 24 hours. The reaction mixture is filtered to give 0.71 g of orange solids which gives only an origin spot on thin layer chromatography. The filtrate is evaporated to dryness under vacuum to give 3.30 g of yellow solid. Nuclear magnetic resonance of the material shows the presence of the product. The material is purified on a column of activity III neutral alumina. Elution with chloroform, followed by 1% methanol/chloroform and 5% methanol/chloroform gives thiadiazole starting material. Elution with 10%, 208 and 50% methanol/chloroform gives 2.32 g (14%) of yellow solid containing product. Recrystallization from acetonitrile gives 1.20 g; m.p. 217-2210(d) of 3-N- [3- (2-guanidino-4-thiazolylphenyl] amino-4-methoxy- 1,2,5-thiadiazole-l-oxide; proton nuclear magnetic resonance is consistent with this structure. It is noted that during the course of this reaction the solvent (methanol) exchanged with the residual methylthio group forming the 4-methoxy compound. This does not affect the reaction, since the second amine can react with either the 4-methoxy compound or the 4-methylthio compound. B. 3-N-13-{2-Guanidino-4-thiazolyl)phenylZamino-4- methylamino-1,2,5-thiadiazole-l-oxide 0.37 G of a 33% methylamine/methanol solution (0.12, 0.0040 mol) is added to a suspension of 1.27 g (0.0035 mol) 3-N-[3-(2-guanidino-4thiazolyl)phenyl]-amino-4-methoxy-1,2,5-thiadiazolel-oxide in 30 ml of methanol with stirring. The solids dissolve and after 30 minutes a precipitate begins to form. The reaction is complete within 2 hours by thin layer chromatography and the precipitate is filtered and dried to give 0.76 g (70*) of crude product. The product is dissolved in 5 ml of dimethyl sulfoxide and filtered. Methanol is added to the solution to give a precipitate which is filtered and dried to give 0.97 g; m.p. 160-1610C(-d) of product; proton nuclear magnetic resonance is consistent with structure of 3-N-[3-(2-guanidino-4 thiazolyl)phenyl]amino-4-methylamino-1,2,5-thiadiazole- l-oxide. EXAMPLE 6 3-N-[3-(2-Guanidino-4-thiazolyl)phenyllamino-4-methyl amino-1,2,5-thiadiazole-1,1-dioxide A. 3-N-[3-(2-guanidino-4-thiazolyl)phenyl]amino-4- ethoxy-1,2,5-thiadiazole-l,lldioxide A solution of 1.17 g (0.005 mol) of 3-(2 guanidino-4-thiazolyl)benzeneamine in 30 ml of ethanol is added to a slurry of 1.03 g (0.005 mol) of 3,4 diethoxy-1,2,5-thiadiazole-1,l-dioxide in 30 ml of ethanol with stirring. All solids dissolve within one minute and a precipitate begins to form within two minutes. The reaction mixture is stirred for 5 ours, at which time the reaction is complete by thin layer chromatography. The precipitate is filtered, dried and recrystallized from ethanol to give 1.35 g of 3-N- [3- (2-guanidino-4-thiazolyl) phenyl] amino-4- ethoxy-l,2,5-thiadiazole-l,l-dioxide m.p. 237-2390C. B. 3-N-[3-(2-Guanidino-4-thiazolyl)phenyl3amino-4- methylamino-l, 2, 5-thiadiazole-l, 1-dioxide 0.70 G of a 33% methylamine/methanol solution (0.23 g, 0.0075 mol) is added to a suspension of 2.91 g (0.0075 mol) of 3-N-[3-(2guanidino-5-thiazolyl)phenyl]amino-4-ethoxy-1,2,5-thia- diazole-l,l-dioxide from Part A of this example in 75 ml of methanol. The mixture is stirred at room temperature for 3 hours, at which time the reaction is complete by thin layer chromatography. The reaction mixture is filtered to give 1.30 g of yellow solid which gives only an origin spot on thin layer chromatography. The filtrate is evaporated to dryness under vacuum to give 2.00 g (70%) of a yellow solid. Recrystallization from water gives 0,72.gm-,p. 263-2650C; proton nuclear magnetic resonance isconsistent with the structure of 3-N-[3-(2 guanidino-4-thiazolyl)phenylZamino-4-methylamino-1,2,5- thiazdiazole-l,l-dioxide. EXAMPLE 7 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methylthio]- ethyl]amino-4-(2-propynyl)amino-l,2,5-thiadiazole- l-oxide 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)- methylthio3ethyl]amino-4-ethoxy-1,2,5-thiadiazole-1- oxide (5.37 g, 0.015 mol) is dissolved in 30 ml of tetrahydrofuran and a solution of 2-propynylamine (0.91 g, 0.0165 mol) in 5 ml of tetrahydrofuran is added dropwise over several minutes. The reaction mixture is stirred at room temperature for 72 hours. Removal of the solvent in vacuo gives a dark amber oil. Chromatography on silica gel using 5% methanol/ chloroform gives 3.2 g of a light amber oil. Proton nuclear magnetic resonance is consistent with the proposed structure. EXAMPLE 8 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methylthio]- ethyl] amino-4-amino-I,2,5-thiadiazole-l-oxide 3-N- [2- [(5-Dimethylaminomethyl-2-furanyl) - methylthio] ethyl] amino-4-ethoxy-l,2,5-thiadiazple-l- oxide (5.37 g, 0.015 mol) is dissolved in 10 ml of tetrahydrofuran and a solution of anhydrous ammonia (1.7 g, 0.10 mol) dissolved in 10 ml of cold tetra hydrofuran is added at ice bath temperature. The reaction is stirred at ice bath temperature forseveral hours and then at room temperature overnight. Removal of the solvent in vacuo gives a viscous oil which solidifies upon trituration in petroleum ether affording 4.8 g of a pale beige solid. Recrystallization from nitromethane gives 2.7 g of a pale tan solid m.p. dec. 132-136 C. EXAMPLE 9 3-N-[2-[ (2-Guanidino-4-thiazolyl)methylthio]ethyl] amino-4-methylamino-1,2,5-thiadiazole-1,1-dioxide In a procedure similar to Example 3 using 1.16 g (5.0 mmol) of the amine and 0.96 g (5.0 mmol) of 3-ethoxy-4-methylamino-1,2,5-thiadiazole-1,1- dioxide, there is obtained 0.65 g of 3-N-[2-[ (2-guanidino-4-thiazolyl)methylthio]ethyl] amino-4-methylamino-1,2,5-thiadiazole-1,1-dioxide, m.p. 182-1840, dec. after recrystallization from water; IR-SO2 stretching vibrations 1350, 1150 cm1 (KBr); proton magnetic resonance is consistent with structure. EXAMPLE 10 3-N-f3-[3-(Dimethylaminomethyl)phenoxy]propyl]amino- 4-amino-l-;2,5-thiadiazole-l-oxide To a solution of 3-[3-ldimethYlaminomethyl) phenoxy]propylamine (2.9 gm, 0.0139 mol) in acetonitrile (9 ml) is added 3-ethoxy-4-amino-1,2,5thiadiazole-l-oxide (2.25 gm, 0.014 mol). Complete dissolution occurs almost immediately and product begins to precipitate after 1/4 hour. The reaction is stirred at ambient temperature for about 16 hours and pure product is collected by filtration. The white solid is washed with acetonitrile, ether and air dried to give 4.35 gm of 3-N-[3-[3-dimethylamino methyl)phenoxy]propyl]amino-4-amino-1,2,5-thiadiazole-1 -oxide m.p. 159-1620C. EXAMPLE 11 3-Nt2-[[3--(Dimethylaminomethyl)phenyl]methylthio3- ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide To a solution of 2-[[3-(dimethylaminomethyl)phenyl]methylthio]ethylamine (3.36 gm, 0.015 mol) in acetonitrile (10 ml) at room temperature is added 3 ethoxy-4-amino-1,2,5-thiadiazole-l-oxide (2.42 gm, 0.015 mol). Complete dissolution occurs within 5 minutes and product begins to precipitate after 1/2 hour. The reaction is stirred at ambient temperature for about 16 hours and the product collected by filtration, washed with acetonitrile, ether and air dried to give 3.7 gm of crude product. Crystallization from acetonitrile gives pure 3-N-[2-[[ 3-(dimethylamino-methyl)phenyl]methylthio]ethyl]amino-4 -amino-l,2,5-thiadiazole-l-oxide as tan rosettes, m.p. 120-1230C. EXAMPLE 12 3-N-[3-r3-(Dimethylaminomethyl)phenoxy]propyl]amino- 4-methylamino-1,2,5-thiadiazole-1-oxide hydrochloride 3-[3-(Dimethylaminomethyl)phenoxy]propyl- amine (1.716 g, 0.00823M) dissolved in THF (7 ml) is added to 3-ethoxy-4-methylamino-1,2,5-thiadiazole-1oxide (1.443 g, 0.00823M) suspended in THF (7 ml). The resultant solution is stirred at ambient temperature for 18 hours and concentrated under vacuum. The residue is chromatographed on silica andeluted with 10% methanol-chloroform to obtain the product gum (2.5 g). The product is dissolved in ethanol (10 ml), acidified with 6N ethanolic HC1, precipitated with diethyl ether, filtered and dried under vacuum at 550C to obtain the 3-N-[3-[3- (Dimethylaminomethyl)phenoxy]propyl]amino-4-methyl- amino-1,2,5-thiadiazole-l-oxide hydrochloride m.p. 90(d) solvated with diethyl ether. EXAMPLE 13 3-N-[3-[3-(l-piperdinylmethyl)phenoxy]propyl]amino-4- methylamino-1,2,5-thiadiazole-l-oxide hydrochloride 3-[3-(l-Piperidinylmethyl)phenqxy] propaneamine (2.48 g, 0.01M) in THF (4 ml) is reacted with 3-ethoxy-4-methylamino-l,2,5-thiadiazole-l- oxide (1.87 g, 0.0107M) in THF (35 ml) by the method of Example 12 affording 3-N-[3-[3-(-piperidinyl methyl)-phenoxy]propyl]amino-4-methylamino-1,2,5- thiadiazole-l-oxide hydrochloride as a non-crystalline solid solvated with ethyl alcohol. EXAMPLE 14 3-N-[3-[3-t(4-Methyl-l-piperazinyl)methyl3phenoxyl- propyl]amino-4-methylamino-1,2,5-thiadiazole-1-oxide Hydrochloride A 3-[3-[(4-Methyl-l-piperazinyl)methyl]phenoxy]- pr opaneamine To 2- [3- [3-formylphenoxy]propyl] -lH-iso- indole-1,3-dione (20 g, 0.0647MJ) suspended in ethylacetate (50 ml) 1-methylpiperazine (19.53 g, 0.195M) is added and the mixture stirred at ambient temperature 45 minutes longer than the time required to effect solution. Acetic acid (23.1 g, 0.385M) in amixture of ethylacetate (40 ml) and ethanol (80 ml) is added along with 10% palladium on carbon (3 g). The mixture is hydrogenated (50 lbs/sq. in.), filtered and the filtrate concentrated under vacuum. The residue is dissolved in dilute hydrochloric acid and extracted with methylene chloride. The aqueous phase is basified with solid sodium carbonate and extracted with methylene chloride. The organic extracts are dried over sodium sulfate and concentrated under vacuum. The residual oil (21 g) is stirred in a mixture of ethanol (250 ml) and 64% hydrazine (100 ml) for 90 hours at ambient temperature. The mixture is diluted with diethylether, filtered and the filtrate concentrated under vacuum and the residue distilled. The product is obtained by collecting the fraction distilling at 215-230/1.5 mm. weight 9.7 g. B. 3-N- [3- [3- [ (4-Methyl-l-piperazinyl)methyl] phenoxy]-propylAamino-4-methylamino-1,2,5-thiadiazole-1 -oxide Hydrochloride By reacting 3-[3-[(4-methyl-1-piperazinyl3- methyl]phenoxy]propaneamine (3.1 g, 0.0118M) in THF (3 ml) with 3-ethoxy-4-methylamino-l,2,5-thiadiazole- l-oxide as described in Example 12, 3-N-[3-[3 [(4-methyl-1-piperazinyl3methylXphenoxyZpropyl3amino- 4-methylamino-1,2,5-thiadiazole-1-oxide hydrochloride is obtained; m.p. 780 with decomposition. EXAMPLE 15 3-N-[3-[3-(4-Morpholinomethyl)phenoxy]propyl]amino- 4-methylamino-1,2,5-thiadiazole-1-oxide Hydrochloride A. 3-[3-(4-Morpholinomethyl)phenoxy]propaneamine By reacting 2-[3-[3-formylphenoxy3propyll- lH-isoindole-1,3-dione (20 g, 0.0647M) with morpholine(16.9 g, 0.194M) under the conditions described in Example l4A, and isolating the product in a similar manner there is obtained 11.6 g of 3-[3-(4morpholinomethyl)phenoxy]propaneamine b.p. 188-98 at 1.5 mm. B. 3-N-[3-(4-Morpholinomethyl)phenoxyApropyl3amino-4- methylamino-;2,5-thiadiazole-l-oxide hydrochloride By reacting 3-[3-(4-morpholinomethylOphenoxy] propaneamine (3.0 g, 0.012M) in THF (4 ml) with 3 ethoxy-4-methylamino-l,2,5-thiadiazole-l-oxide (2.27 g, 0.0129M) in THF (4 ml) as described in Example 12, 3-N-[3-(4-morpholinomethyl)phenoxy]propyl]amino-4- methylamino-1,2,5-thiadiazole-l-oxide hydrochloride is obtained; m.p. 90-950C with decomposition. EXAMPLE 16 3-N-[3-[3-(4-Morpholinomethyl)phenoxy]propyl]amino-4- amino-1,2,5-thiadiazole-l-oxide 3-[3-(4-Morpholinomethyl)phenoxy]propaneamine (2.858 g, 0.01142M) in acetonitrile (4 ml) is reacted with 3-ethoxy-4-amino-l,2,5-thiadiazole-l-oxide (1.933 g, 0.012M) suspended in acetonitrile (5 ml). After stirring 20 hours at ambient temperature the crystalline product is filtered, washed with acetonitrile, and dried under vacuum at 650 affording 3-N-(3-[3-(4-morpholinomethyl)phenoxy] propyl]amino-4-amino-1,2,5-thiadiazole-1-oxide; m.p. 185-186.50 with decomposition. EXAMPLE 17 3-N-[2-[(4-Mehyl-5-imidazolyl)methylthi 4-methylamino-1,2,5-thiadiazole-1-oxide hydrochloride 2-[(4-Methyl-5-imidazolyl)methylthio] ethylamine (1.838 g, 0.01073M) dissolved in a mixtureof tetrahydrofuran and methylene chloride (3 ml) is added to 3-ethoxy-4-methylamino-1,2,5-thiadiazole-1- oxide (1.8804 g, 0.01073M) and stirred at ambient temperature for 20 hours. The reaction mixture is concentrated under vacuum, the residue is dissolved in isopropanol (10 ml) acidified with ethanolic hydrochloride and diluted with diethyl ether. The crude product is filtered, redissolved in isopropanol (15 ml) and this solution diluted to 500 ml with acetonitrile. The mixture is filtered, the solid discarded, the filtrate concentrated in vacuum. The residue (2.6 g) is dissolved in isopropanol (12 ml) and the product precipitated with diethyl ether affording 3-N-[2-[ (4-methyl-5-imidazolyl)methylthio] ethyleamino-4-methylamino-1,2,5-thiadiazole-1-oxide hydrochloride m.p. 1l80(d). EXAMPLE 18 3-N- [2- [ (5-Dimethylaminomethyl-2-furanyl)methylthio] ethyl3amino-4-amino-1,2,5-thiadiazole-1,1-dioxide To a filtered solution of 2-[(5-dimethyl aminomethyl-2-furanylmethylthio3ethyl amine (8.35 g, 39.0 mmol) in 70 ml methanol is added 6.9 g (38.9 mmol) of 3-ethoxy-4-amino-1,2,5-thiadiazole-1,1- dioxide. The clear solution is stirred 2 hours at room temperature during which a white precipitate separates. The precipitate is collected, boiled with 125 ml ethyl acetate, and refiltered to give 10.4 g of the pure title compound; m.p. 159-1600C with decomposition. EXAMPLE 19 3-N[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]amino-4- amino-1;2,5-thiadiazole-l-oxide A solution of 13.66 g (0.055 mol) of 3-[3-(1- piperidinylmethyl)phenoxy]propane amine in 5 ml of CH3CN is added to 8.87 g (0.055 mol) of 3-ethoxy-4 amino-1,-2,5-thiadiazole-1-oxide in 200 ml of CH3CN. The solution is stirred at room temperature under nitrogen and colorless product begins to precipitate in about 15 minutes. After 24 hours the reaction mixture is filtered and the product is washed with CH3CN. The product is suspended in 75 ml of CH,-3CN and stirred for 24 hours in a closed vessel. The solid is collected and again stirred with CH3CN for 48 hours. The solid is then collected and dried for 4 hours at 780 under vacuum to obtain 16.0 g (80%) of the pure product, m.p. 152.5-154.5 . EXAMPLE 20 3-N-[2-1[6-(4-tAorpholinylmethyl)-2-benzofuranyllmethyl- thio] ethyl] amino-4-amino-l,2,5-thiadiazole-l-oxide A. Ethyl 6-Methylhenzofuran-2-carboxylate A solution of 6-methylbenzofuran-2-carboxylic acid (111.0 g., 0.636 mole) and concentrated sulfuric acid (4 ml.) in ethanol (1 1.) is boiled under reflux for 16 hours. About 2/3 of the solvent is removed by distillation at reduced pressure. The residue is poured into 1 1. of ice water. The oily ester is taken up in ether, washed with saturated sodium bicarbonate solution and water and dried over sodium sulfate. Distillation at reduced pressure affords 90.5 g. (70%) of ethyl 6-methylbenzofuran-2-carboxylate, b.p. 174-1760C (17 mm.). The product crystallizes in the receiver, m.p. 35-420C. B. Ethyl 6- (bromomethyl) benzofuran-2-carboxylate N-Bromosuccinimide (37.4 g., 0.21 mole) is added to a solution of ethyl-6-methylbenzofuran-2carboxylate (40.8 g., 0.2 mole) and a,a'-azobisisobutyronitrile (500 mg.) in carbon tetrachloride (300 ml.). The suspension is boiled under reflux for 3 hours. It is then cooled and the succinimide removed by filtration. The carbon tetrachloride solution is washed with water and dried over sodium sulfate. The solution is then evaporated at reduced pressure. The solid residue is recrystallized from hexane to yield 47.4 g. (69%) of crystalline ethyl 6-(bromomethyl)benzofuran-2-carboxylate, m.p. 95-1020C. NMR (CDC13): g 1.40 (3H,t,CH3), 4.40(2E,q,CH20),4.58 (2H,s,CH2Br) C. Ethyl 6-(4-Morpholinylmethyl)benzofuran-2- carboxylate To a solution of 10.0 g (0.035 mol) of ethyl 6-(bromomethyl) benzofuran-2-carboxylate in 100 ml of ether at 0-4 is added dropwise a solution of 7.7 g (0.088 mol) of morpholine in 100 ml of ether. The - mixture is stirred 18 hours, water is added and the layers separated. The organic layer is extracted with 3N hydrochloric acid. The acid extract is made basic with 10N sodium hydroxide and extracted with ethyl acetate. The extract is dried and concentrated to yield 8.4 g (86%) of ethyl 6-(4-morpholinylmethyl) benzofuran-2-carboxylate. D. 2-Hydroxymethyl-6- (4-morpholinylmethyl) benzofuran To a suspension of 2.1 g (0.03 mol) of lithium aluminum hydride in 50 ml of ether is added, dropwise at room temperature, a solution of 8.4 g (0.03 mol) of ethyl 6- (4-morpholinylmethyl) benzofuran-2-carboxylate in25 ml of ether. The mixture is stirred 18 hours, saturated Na2 SO4 is added until a white suspension occurs and the solid is filtered. The solid is washed with chloroform and the filtrate is extracted with water. The chloroform-ether solution is concentrated to yield 4.7 g (63%) of 2-hydroxy methyl-6- (4-morpholinylmethyl)benzofuran, m.p. 105-1070C. E. 2-[t6-(4-Morpholinylmethyl)-2-benzofuranyl]methyl- thio]ethane amine 2-Hydroxymethyl-6-(4-morpholinylmethyl) benzofuran 4.7 g (0.02 mol) is added in portions to an ice-cooled solution of 2.4 g (0.02 mol) of cysteamine hydrochloride in 10 ml of 12N HC1 under nitrogen. The ice bath is removed and the solution is stirred for 17 hours at room temperature. It is cooled, adjusted to pH 10 with 40% NaOH and extracted with methylene chloride. The extract was concentrated to yield 6 g of 2-[[6-(4-morpholinyl- methyl)-2-benzofuranyl]methylthio]ethane amine. F. 3-N-f2-[t6-(4-Morpholinylmethyl)-2-benzofuranyl] methylthio]ethyl]amino-4-amino-1,2,5-thiadiazole-1- oxide By the method of Example 11, using 2-tf6-(4- morpholinylmethyl)-2-benzofuranyl]methylthio]ethane amine, the title compound is obtained as a white solid, m.p. 143-1460C. EXAMPLE 21 3-N-[2-[r6-(4-Morpholinylmethyl)-2-benzofuranylXmethyl- thiolethyllamino-4-amino-1,2,5-thiadiazole-l,l-dioxide Using the method of Example 18.with 2-[[6-(4 morpholinylmethyl) -2-benzofuranyl] methylthio] ethane amine as the amine reagent and acetonitrile as the solvent, the title product is obtained as a light yellow solid, m.p. 164-1670C. EXAMPLE 22 3-N-12-[[6-(4-Morpholinylmethyl)-2-benzofuranyl]methyl- thio3ethyl]amino-4-methylamino-1,2,5-thiadiazole-1- oxide By the method of Example 1B using as the amine reagent 2-[16-(4-morpholinylmethyl) -2-benzofuranyl] methylthio] ethane amine and acetonitrile as the solvent, with a six day reaction time, a crude product is obtained. Chromatography on silica gel yields the pure title compound; m.p. 139-1430C. EXAMPLE 23 3-N-12-[[5-(4-Morpholinylmethyl)-2-furanyl]methylthio] ethylEamino-4-amìno-1,2,5-thiadiazole-1-oxide By the method of Example 11, using 2-[[5-(4 morpholinylmethyl) -2-furanyl]methylthio]ethane amine as the amine reagent, the title compound is obtained as a crystalline solid, m.p. 142-1440C. EXAMPLE 24 3-N-[2-[[5-(1-Piperdinylmethyl)-2-furanyl]methylthio] ethyl] amino-4-amino-l, 2 ,5-thiadiazole-1-oxide By the method of Example 11, using 2-[[5-(1-piperidinylmethyl)-2-furanyl]methylthiol ethane amine as the amine reagent, the title compound is obtained as a solid, m;p. 1500. EXAMPLE 25 3-N-r2-[(4-Methyl-5-imidazolyl)methylthio]ethyl3amino- 4-amino-1,2,5-thiadiazole-l-oxide By the method of Example 11, using 2-[(4-methyl-5-imidazolyl)methylthio]ethane amine asthe amine reactant, the title product is obtained in an impure condition. Chromatograhy on silica gel followed by precipitation from an isopropyl alcohol-ether mixture yields the pure title compound containing 0.31 molar equivalent of isopropyl alcohol; m.p. 98-126 . EXAMPLE 26 3-N-[2-[(4-Methyl-5-imidazolyl)methylthio]ethyl]amino- 4-amino-l,2,5-thiadiazole-l,l-dioxide By essentially the method of Example 18 using 2- [ (4-methyl-5-imidazolyl)methylthio] ethane amine as the amine reactant and acetonitrile as the solvent, the title product is obtained. It is purified by chromatography on silica gel and precipitation from an ethanol-ether mixture to yield the pure title compound containing 0.5 molar equivalent of ethanol; m.p. 78-92 . EXAMPLE 27 3-N-[2-[(2-Guanidino-4-thiazolyl)methylthio]ethyl] amino-4-amino-1,2,5-thiadiazole-1-oxide Replacing the 3-ethoxy-4-methylamino-1,2,5thiadiazole-l-oxide in Example 3 with 3-ethoxy 4-amino-1,2,5-thiadiazole-1-oxide and purifying the product by chromatography on silica gel and crystallization yields the title compound; m.p. S86-188 . EXAMPLE 28 3-N- [3- (2-Guanidino-4-thiazolyl) phenyl] amino-4-amino- 1, 2, 5-thiadiazole-l-oxide Using the procedure of Example 5 and replacing the methylamine solution in part 5B with a solution of ammonia in alcohol there is obtained a crystalline product which is recrystallized from dimethyl sulfoxide-acetonitrile mixture to give the pure title compound containing a molecule of crystallization of dimethyl sulfoxide; m.p. 219-220 . EXAMPLE 29 3-N-[2-t(6-Dimethylaminomethyl-2-pyridyl)methylthio] ethyl]amino-4-amino-l,2,5-thiadiazole-l-oxide Hydrochloride Hemihydrate By replacing the 2[[3-(dimethylaminomethyl) phenyl]methylthio]ethyl amine of Example 11 with 2-[(6-dimethylaminoethyl-2-pyridyl)methylthio3ethane amine [disclosed in British Pat. 2,038,804] and carrying out the reaction and workup, in a similar manner there is obtained 3-N-[2-[(6-dimethylamino methyl-2-pyridyl) methylethio] ethyl] amino -4-amino-1,2,5-thiadiazole-l-oxide. This base is dissolved in an equivalent amount of aqueous hydrochloric acid and the solution is lyophilized to yield the pure title compound hydrochloride salt as a hemihydrate in a glassy solid form. EXAMPLE 30 3-N-[3-[3-(Dimethylaminomethyl)phenoxy]propyllamino-4amino-1,2,5-thiadiazole-1,1-dioxide By replacing the 3-ethoxy-4-amino-1,2,5thiadiazole-l-oxide of Example 10 with 3-ethoxy-4-amino-1,2,5-thiadiazole-1,1-dioxide and carrying out the reaction in a similar manner in acetonitrile, a crystalline product is obtained. Recrystallization from nitromethane yields the title compound; m.p. 173-175 . EXAMPLE 31 3-N-[2-[(5-Dimethylaminomethyl-2-thienyl)methylthio] ethyl] amino-4-amino-1, 2, 5-thiadiazole-l-oxide 2- [ (5-Dimethylaminomethyl-2-thienyl) methyl- thio]ethane amine and 3-ethoxy-4-amino1,2,5-thiadiazole-1-oxide are allowed to react in acetonitrile solution according to the procedure of Example 11. The reaction product is purified by chromatography and then crystallization from an acetonitrile-methanol mixture to give the pure title compound; m.p. 143-1470, EXAMPLE 32 3-N- [2- (5-Methylaminomethyl-2-furanyl)methylthioi ethyli amino-4-amino-l,2,5-thiadiazole-l-oxide The reaction of 2-[(5-methylaminomethyl-2furanyl)methylthio]ethane amine with 3-ethoxy-4-amino-l,2,5-thiadiazole-l-oxide in acetonitrile is carried out by the procedure described in Example 11. The crude product is chromatographed on silica gel and then crystallized from ethyl alcohol to yield the pure title compound; m.p. 153-1560, EXAMPLE 33 3-N-[3-[3-[(4-Methyl-1-piperazinyl)methyl]phenoxy] propyl]amino-4-amino-1,2,5-thiadiazole-1-oxide By the method of Example 10, using 3-[3 [(4-methyl-l-piperazinyl)methyl]phenoxyipropane amine [prepared as in Example 14] as the propane amine reagent, a product is obtained which is crystallized from a chloroform-ether mixture to give the pure title compound; m.p. 1330 with decomposition. EXAMPLE 34 3-N-[2-[(4-Methyl-5-oxazolyl)methylthio]ethyl]amino-4- amino-1;2,5-thiadiazole-l-oxide The reaction of 2-[(4-methyl-5-oxazolyl) methylthio]ethane amine with 3-ethoxy-4-amino-1,2,5thiadiazole-l-oxide in acetonitrile solvent by the procedure of Example 11 yields the title compound; m.p. 148-150 . EXAMPLE 35 3-N-[3-(6-Dimethylaminomethyl-2-pyridylthio)propyl] amino-4-amino-1,2,5-thiadiazole-l-oxide A. 3-(6-Dimethylaminomethyl-2-pyridylthio)propane amine A mixture of 3-mercaptopropylamine (4.8 g, 0.053 mol) and 60% sodium hydride in mineral oil(2.18 g, 0.054 mol) in dry dimethylformamide (50 ml) is heated to 800C and a solution of 6-dimethylaminomethyl-2-chloropyridine (8.7 g, 0.051 mol) in 50 ml of dry DMF is added dropwise. The mixture is heated at 1250 for 3 hours, then cooled, diluted with ethanol (70 ml) and, after filtration to remove precipitated salts, evaporated to dryness. This residue is dissolved in water and the product is extracted into chloroform, then into dilute HC1 and the acidic extract is neutralized with Na2CO3 and the product is extracted into chloroform, dried and evaporated to give 9.5 g. This residual oil is distilled to give 5.64 g of the pure title product; bp: 129-1330C/0.5 mm. B. 3-N- [3- (6-Dimethylaminomethyl-2-pyridylthio) propyl] amino-4-amino-l, 2, 5-thiadiazole-l-oxide Hydrochloride The amine product from part A is reacted with 3-ethoxy-4-amino-l,2,5-thiadiazole-l-oxide essentially by the process of Example 10. The reaction product is chromatographed, dissolved in methanol, and an equivalent amount of alcoholic HC1 is added. Acetonitrile is added and the pure title compound, m.p. 174-176 , is obtained. EXAMPLE 36 3-N- [2- (6-Dimethylaminomethyl-2-pyridylthio) ethyl] amino -4-amino-1,2,5-thiadiazole-l-oxide A. 2-(6-Dimethylaminomethyl-2-pyridylthio)ethane amine Cysteamine hydrochloride (3.43 g, 0.030 mol) is'added to a suspension of 60% sodium hydride in mineral oil (2.5g., 0.0625 mol) in dry dimethylformamide(30 ml) and is warmed to 800C. A solution of 6-dimethylaminomethyl-2-chloropyridine (5.0 g, .0284 mol) in 30 ml of dry DMF is added dropwise and then the reaction temperature is increased to l250C for 2 hours. Then, the reaction is cooled, diluted with ethanol (60 ml) and the salts are removed by filtration before evaporating to dryness. This residue is dissolved in chloroform, washed with water and extracted into diluted SC1. This acidic extract is neutralized with Na2CO3 and the product extracted into chloroform dried and evaporated to give 4.4 g. This residual oil is distilled to give 2.74 g of the pure title product; bp: 109-1140C/0.25 mm. B. 3-N- [2- (6-Dimethylaminomethyl-2-pyridylthio) ethylaamino-4-amino-1,2,5-thiadiazole-1-oxide The amine product from part A is reacted with 3-ethoxy-4-amino-l,2,'5-thiadiazole-l-oxide essentially by the process of Example 10. The pure title compound, m.p. 172-1750, crystallizes from the reaction mixture. EXAMPLE 37 3-N- [3- (6-Dimethylaminomethyl-2-pyridyloxy) propyl] amino-4-amino-l, 2, 5-thiadiazole-l-oxide A. N-t3-(6-Dimethylaminomethyl-2-pyridyloxy)propyl] formamide 3-Aminopropanol (2.55 g, 0.034 mol) is added to a suspension of 60% sodium hydride in mineral oil (1.29 g, 0.033 mol) in dry dimethylformamide (30 ml) and the mixture is warmed to 800C before adding dropwise a solution of 6dimethylaminomethyl-2-chloropyridine (5.45 g, 0.032mol) in 30 ml of dry DMF. The reaction temperature is increased to 1250C for 3 hours, then the reaction is cooled, diluted with ethanol and the precipitated salts filtered. The solvents are removed under vacuum. The residue is dissolved in chloroform, washed with water, extracted into dilute HC1 and the acidic extract neutralized with Na2CO3. The crude product is extracted into chloroform, dried and evaporated (7.6 g). This residue is chromatographed on silica gel (200 g) eluting with 3-8% methanol/chloroform to give 3.2 g of the pure title product as an oil. B. 3- (6-Dimethylaminomethyl-2-pyridyloxy) propylamine N-[3-(6-Dimethylaminomethyl-2-pyridyloxy) propyl]formamide (2.7 g 0.013 mol) is added to a solution of 85% potassium hydroxide pellets (3.0 g) dissolved in methanol (30 ml) and heated at gentle reflux for 21 hours. The reaction is cooled, diluted with diethyl ether (30 ml), the precipitated salts filtered, and the solvent removed under vacuum. The residue is dissolved in water and the product exhaustively extracted into ethanol/chloroform, dried and evaporated to give 2.1 g of the pure title product. C. 3-N- [3- (6-Dimethylaminomethyl-2-pyr idy1oxy) propyl]amino-4-amino-1,2,5-thiadiazole-1-oxide The amine product from part B is reacted with 3-ethoxy-4-amino-l,2,5-thiadiazole-l-oxide essentially by the process of Example 10. Reaction product is purified by chromatography and crystallization from methyl alcohol-acetonitrile mixture to give the title compound; m.p. 139.1420. EXAMPLE 38 3-N-[3-(2-Pyridylthio)propyl]amino-4-aminó-1-,2,5- thiadiazole-l-oxide 3-(2-Pyridylthio)propyl amine is reacted with 3-ethoxy-4-amino-l,2,5-thiadiazole-l-oxide by the process of Example 10. The reaction product is recrystallized from a mixture of chloroform and methyl alcohol to yield the pure title compound; m.p. 177-1790C. EXAMPLE 39 3-N-[2-[(2-Pyridyl)methylthiolethyl]amino-4-amino- 1,2,5-thiadiazole-1-oxide The reaction of 2-[(2-pyridyl)methylthio] ethane amine with 3-ethoxy-4-amino-1,2,5-thiadiazole -l-oxide is performed essentially as described in Example 11. The reaction product is purified by chromatography and crystallization from a methyl alcohol-acetonitrile mixture to give the title compound; m.p. 102.104*. EXAMPLE 40 3-N- [2- [(2-Pyrazinyl)methylthio] ethyl] amino-4-amino- 1,2,5-thiadiazole-l-oxide By reacting 2-[(2-pyrazinyl)methylthio] ethane amine with 3-ethoxy-4-amino-l,2,5-thiadizaole -l-oxide under conditions described in Example 11 and purifying the product by chromatography and crystallization from an acetonitrile-methyl alcohol mixture, the pure title compound; m.p. 148-1500, is obtained. EXAMPLE 41 3-N-[2-[(4-Methyl-5-thiazolyl)methylthio]ethyl]amino-4- amino-12,5-thiadiazole-l-oxide A. 2- [ (4-Methyl-5-thiazolyl)methylthio] ethaneamine To 95 ml 48% HBr cooled in an ice bath, cysteamine hydrochloride (7.96 g, 0.07M) is added and the mixture stirred until a solution forms. To this solution 4-methyl-5-thiazolylmethanol (9.05 g, 0.07M) is slowly added. After stirring at 250 for 1/2 hour, the mixture is refluxed for 5 hours then, while cooled in an ice bath, made alkaline with sodium hydroxide (ION). The solution is extracted several times with methylene chloride. The methylene chloride extracts are diluted with an equal volume of ether, washed once with brine and dried over sodium sulfate. The solution is filtered and concentrated under vacuum and the residue distilled to obtain the colorless title product oil (10.05 g, 76%); b.p. 121.5-125 / 0.7 mm. B. 3-N- [2- [ (4-Methyl-5-thiazolyl)methylthio]ethyl] amino-4-amino-1,2,5-thiadiazole-1-oxide The amine from part A is reacted with 3-ethoxy-4-amino-l,2,5-thiadiazole-l-oxide by the procedure of Example 11 using tetrahydrofuran as the reaction solvent. Recrystallization of the product from methyl alcohol yields the pure title compound; m.p. 157-159 . EXAMPLE 42 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methylthio] ethyl3amino-4-N-(2-phenylethyl)amino-1-,2,5-thiadiazole- 1-oxide A. 3-Ethoxy-4-N- (2-phenylethyl) amino-l,2,5- thiadiazole-l-oxide To a solution of 9.51 g (0.05 ml) of 3,4 diethoxy-1,2,5-thiadiazole-l-oxide in 20 ml of tetrahydrofuran (THF) at - 100 is added a solution of 6.6 g (0.05 mol) of 2 phenylethane amine in 50 ml of THF over a 2 hour period. The mixture is stirred for 18 hours in an ice bath and then is concentrated under vacuum. The residue is washed with ether and then recrystallized from acetonitrile to give 10.8 g of 3-ethoxy-4-N- (2-phenylethyl) amino-l,2,5- thiadiazole-l-oxide; m.p. 116-118 . B. 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl) methylthio]ethyllamino-4-N-(2-phenylethyl)amino-1,2,5- thiadiazole-l-oxide The product from part A and an equimolar amount of 2-[(5-dimethylaminomethyl-2-furanyl) methylthio]ethyl amine are stirred in THF essentiaily by the procedure of Example 12. The crystalline reaction product is recrystallized from acetonitrile-ether mixture to give the title compound; m.p. 92.5-94,50. EXAMPLE 43 3-N-[2-1(5-Dimethylaminomethyl-2-furanyl)methylthio] ethyllamino-4-N-[2-(4-pyridyl)ethylAamino-1,2,5- thiadiazole-l-oxide A. 3-Ethoxy-4-N-[2-(4-pyridyl)ethyl]amino 1,2,5- thiadiazole-l-oxide By replacing the 2-phenylethan amine obtained in part A of Example 42 with an equimolar amount of 2-(4-pyridyl)ethane amine and proceeding in a similar manner, 3-ethoxy-4-N-[2-(4-pyridyl)ethyl] amino-1,2,5-thiadiazole-l-oxide crystallized from acetonitrile-ether mixture with m.p. 101-1030 is obtained. B 3-N- [2- [ (5-Dimethylaminomethyl-2-furanyl)methyl- thio]ethyl]amino-4-N-[2-(4-pyridyl) ethyl] amino-l-,2,5- thiadiazole-l-oxide The product from part A of this Example 43 and an equimolar amount of 2-[(5-dimethylaminomethyl2-furanyl)methylthio]ethylamine are stirred in acetonitrile for 48 hours at room temperature. The reaction product is crystallized from ethyl acetate to give the above title compound; m.p. 88-910, EXAMPLE 44 3-N-12-[(2-Furanyl)methylthio3ethyl3amino-4-amino-1¯,2,- 5-thiadazole-1-oxide By reacting 2-[(2-furanyl)methylthio]ethane amine with 3-ethoxy-4-amino-1,2,5-thiadiazole-l-oxide in acetonitrile under conditions described in Example 11 and recrystallizing the solid product from acetonitrile, the pure title compound, m.p. 1640 with decomposition, is obtained. EXAMPLE 45 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methylthio] ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide 3-N-[2-[(2-Furanyl)methylthio]ethyl]amino 4-amino-1,2,5-thiadiazole-l-oxide (from Example 44) and dimethyl(methylene)ammonium iodide are reacted in acetonitrile solvent and heated under reflux for 10 minutes. The solvent is removed by vacuum concentration and aqueous potassium carbonate is added to the residue. After thorough mixing the insoluble, title product is collected and dried. EXAMPLE 46 3-N-t2-[(5-Dimethylaminomethyl-2-furanyl)methylthio] ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide A. 3-N-(2-Hydroxyethyl)amino-4-amino-1,2,5-thia- diazole-l-oxide To a solution of 0.31 g. (0.005 mol) of 2-aminoethanol in 8 ml of acetonitrile and 2 ml of ethanol, one can add 0.8 g. (0.005 mol) of 3-ethoxy 4-amino-1,2,5-thiadiazole-l-oxide. The mixture can then be stirred at ambient temperature for 2 hours and the title product collected by filtration. B. 5-(Dimethylaminomethyl)furfuryl Mercaptan Thiourea (1.52 g., 0.02 mol) is added to a mixture of 1.8 ml. of concentrated HC1 and 1.0 ml of water and cooled to 00. 5-(Dimethylaminomethyl) furfuryl alcohol hydrochloride (3.8-3 g., 0.02 mol) is added and the temperature is slowly increased to 600C and this temperature is maintained one hour. The reaction is then cooled and 1.6 g. (0.04 mol) of: solid sodium hydroxide is added. This mixture is heated under reflux for one hour in a nitrogen atmosphere. The reaction is cooled, extracted with methylene chloride and the extracts evaporated. The residue is extracted with ether and the ether is evaporated to yield an oil which is distilled at 9 mm to give the title product boiling at 109-1130C. C. 3N-[2-[(5-Dimethylaminomethyl-2-furanyl)methyl- thio] ethyl] amino-4-amino-l,2,5-thiadiazole-l-oxide To a solution of carbon tetrachloride (0.483 ml., 0.005 mol) and 1.31 g., (0.005 mol) of triphenylphosphine in 10 ml. of dry dimethylformamide, cooled in an ice bath, one can add 0.005 mol of'3-N-(2-hydroxyethyl)amino-4-amino-l,2,5- thiadiazole-l-oxide. The mixture can then be stirred at room temperature for one hour and 0.81 g., (0.005 mol) of 5- (dimethylaminomethyl) furfuryl mercaptan (from part B above) added. After stirring for 16 hours, the solvent can be evaporated and the residue digested in acetonitrile. The title product can then be collected by filtration. EXAMPLE 47 3-N- [2- (5Dimethylaminomethyl-2-furanyl)methylthio] - ethyl] amino-4-amino-1,2, 5-thiadiazole-l-oxide A. 2-[(5-Dimethylaminomethyl-2-furanyl)methylthio]- ethanol. A solution of 32.4 g. (0.17 mol) of 5- (dimethylaminomethyl) -2-furanemethanol hydrochloride and 17.6 ml of 2-mercaptoethanol in 160 ml 2 N hydrochloric acid is heated with stirring under nitrogen for 1.5 hr then cooled to room temperature overnight. The mixture is then reheated to 700 for 2 hrs., cooled, basified with 50 ml concentrated aqueous ammonia, and extracted with three 100 ml portions of CH2C12. The combined extracts are dried (Na2s04), filtered and concentrated in vacuo to give a thick oil which is distilled to give 24.6 g of 2- [ (5-dimethylaminomethyl-2-furanyl) methylthio]ethanol, bp 1350 (0.5 mm). B. 3-N-[2-[(5-Dimethylaminomethyl-2-furanylXmethyl- thio]ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide A solution of triphenylphosphine (2.62 g. 10 mmol) in 25 ml dry CH3CN can be treated with diethylazodicarboxylate (1.8 g., 10 mmol) with cooling under dry nitrogen. The alcohol from step A (2.15 g. 10.0 mmol) can be added, followed immediately by 3,4-diamino-i,2,5-thiadiazole-l-oxide (1.32 g. 10 mmol). The mixture can then be stirred 36 hr at room temperature, filtered, and the filtrate concentrated in vacuo. The residue can be partitioned between 0.1N HC1 and CH2C12 and the aqeuous acid extracts saturated with Na2C03 and extracted with 5% ethanol in ethyl acetate. The ethyl acetate extracts can then be combined, dried over Na2SO4 filtered and concentrated in vacuo. The title product can then be separated from the starting alcohol by preparative high pressure liquid chromatography. EXAMPLE 48 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methyl- thio]ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide A. 3-N-(2-Mercaptoethyl)amino-4-amino-1,2,5-thia- diazole-l-oxide 3-Ethoxy-4-amino-l , 2, 5-thiadiazole-l-oxide (0.80 g., 0.005 mol) can be added to a solution of 0.385 g (0.005 mol) 2-mercaptoethane amine in 10 ml of ethanol (from 2-mercaptoethane amine hydrochloride and sodium ethoxide) and the mixture stirred for 16 hours. The precipitated title product can then be collected by filtration. B. 3-N-[2-[(5-Dimethylaminoethyl-2-furanyl)methyl thio]ethylaamino-4-amino-1,2,5-thiadiazole-1-oxide 5-Dimethylaminomethylfurfuryl alcohol (0.775 g., 0.005 mol) can be added to a mixture of carbon teterachloride (0.483 ml., 0.005 mole) and triphenylphosphine (1.31 g., 0.005 mole) in 10 ml of dry DMF at 50C. The reaction mixture can then be stirred for one hour at room temperature and 0.005 mol of 3-N-(2-mercaptoethyl)amino-4-amino-l,2,5- thiadiazole-l-oxide added. Stirring can then be continued for 16 hours and the solvent evaporated under reduced pressure. The residue can be digested in acetonitrile and the title product collected by filtration. EXAMPLE 49 Comparison of Compounds Exhibiting Gastric Antisecretory Activity Studies are performed in female beagle dogs with a chronic gastric fistula. The test compounds are administered i.v. at 0 min. Gastric secretion is stimulated by administration of a maximal secretory dose of histamine dihydrochloride (64 pg/kg, base, s.c.) at 0 min. Gastric output is collected by gravity drainage for three 30 min periods (0-30, 30-60 and 60-90 min). Output volume (ml) is measured and an aliquot is titrated to pH 7 to determine acid concentration (titratable acid mEq/L); total acid output (mEq) is calculated as the product of volume and acid concentration. Percent inhibition of volume, acid concentration and total acid output is calculated relative to a placebo trial in the same animals; ED50 values are determined by linear regression analysis. The results obtained with the test compounds are presented in Table I below wherein A and B are representative thiadiazole-l-oxide and thiadiazole-l,l-dioxide compounds of the present invention, and C and D are representative compounds disclosed in the prior art. TABLE I INHIBITION OF HISTAMINE EVOKED GASTRIC SECRETION IN DOGS WITH A CHRONIC GASTRIC FISTULA (1) IV ED50(mg/kg) (2) TEST NO. OF NO. OF ANIMALS/ TOTAL ACID COMPOUNDS DOSES DOSE(3) OUTPUT A 5 4 0.007 B 5 3 0.005 C 2 3 1.1 D 4 4 1.8 (1) Histamine dihydrochloride (64g/kg base s.c.), a maximally effective secretory stimulus. (2) ED50 calculated at period of maximum output in placebo trials (0-30 min. after histamine). (3) (N) minimum number of dogs per dose level. A. 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methyl- thio] ethyl] amino-4-amino-l, 2,5-thiadiazole-1- oxide. (Example 8). B. 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methyl- thio]ethyl]amino-4-amino-1,2,5-thiadiazole-1,1- dioxide. (Example 18). C. 3-N-[2-[(5-Dimethylaminomethyl-2-furanyl)methyl- thio]ethyl]amino-5-amino-l,2,4-triazole, disclosed in Belgian Patent 875,846 (Example. 5) (Derwent Abstract 79110 B/44). D. N-Cyano-N' -methyl-N"- [2- ( (4-methyl-5-imidazolyl) methylthio)ethyl]guanidine, disclosed in U.S. patent 3,950,333 (Examples 24 and 36; Claim 8); in clinical use under the generic name "Cimetidine". As can be seen from the results shown in the foregoing table, compounds A and B of the present invention have potencies that range from about 150 to about 350 times greater than those of prior art compounds C and D. The following preparations are provided to illustrate the processes which can be employed to obtain the novel intermediate compounds of the invention. Unless otherwise indicated, all temperatures are in degrees Celsiuis. PREPARATION 1 3,4Diethoxy-1,2,5-thiadiazole-l-oxide To a solution of 441 g (3.06 moles) of diethyl oximidate in 300 ml of methylene chloride and 780 ml (9.63 mol) of pyridine is added dropwise with cooling 195 ml (3.2 mol) of thionyl chloride at 100+50C. The reaction mixture is stirred for 2 hours at room temperature. The mixture is partitioned between dilute hydrochloric acid and methylene chloride. The methylene chloride is washedonce with dilute hydrochloric and, twice with saturated sodium bicarbonate solution and once with saturated sodium chloride solution. The organic layer is dried with magnesium sulfate, concentrated to a low volume and diluted with hexane. The crystals are removed by filtration, washed in water and dried in vacuo to yield 410 g of 3,4-diethoxy-1,2,5-thiadiazole-1-oxide m.p. = 74-780C. A sample is recrystallized from cyclohexane to yield white crystals m.p. = 75-780C. Mass spectrum 190 (M+ C6HloN2OS), 161 (M+ -C2H5) IR (CHCl3) 1625 (C=N), 1060 CMll (SO) Proton N.M.R. (CDC13),S4.5 (q, J=7Hz, 4H),61.5 (t,J=7Hz, 6H) PREPARATION 2 3,4-Bis-methylthio-1,2,5-thiadiazole-1-oxide To a solution of 353 g [2.39 moles] of bismethylthio oximidate in 1500 ml of methylene chloride and 580 ml of pyridine [7.2 moles] is added dropwise 188 ml [2.59 moles] of thionyl chloride at 0 + 50C. The temperature of the mixture is raised to room temperature and stirred for 2 hours. The mixture is partitioned between methylene chloride and dilute hydrochloric acid. The organic layer is washed once with dilute hydrochloric acid, twice with saturated sodium bicarbonate and once with saturated sodium chloride solution. The organic layer is dried with magnesium sulfate and concentrated to a low volume and diluted with ether. The crystals are filtered, washed with ether and dried to yield 401 g of 3,4-bis-methylthio-l,2,5-thiadiazole-l-o m.p.= 109-1120C. Mass spectrum 194 (M+ C4H6OS3) IR (CHCl3) 1625 (C=N), 1050 CM-Ú (SO) Proton N.M. R. (CDC13) 2.7 ppm s PREPARATION 3 3-Ethoxy-4-methylamino-1,2,5-thiadiazole-1-oxide Anhydrous methylamine (7.7 g, 0.25 mole) is dissolved in 100 ml of tetrahydrofuran with dry iceacetone cooling. This cold solution is added dropwise with stirring to 3,4-diethoxy-l,2,5-thiadiazole-l- oxide (47.5 g, 0.25 mole) in 250 ml of tetrahydrofuran at -l50C over 1-1/2 hours. Stirring is continued for an additional hour at -150C and the solvent is removed in vacuo. The beige solid residue is purified by chromatography on silica gel (100 g) using chloroform. The nearly white solid (39.6 g) melts at 91-920C. IR S=O Stretching vibration 1095 cm 1 13C NMR for thiadiazole-l-oxide carbons: 163.34, 157.36 PREPARATION 4 3-Ethoxy-4-(1-pyrrolidinyl)-1,2,5-thiadiazole-1-oxide To 50.0 g (263 mmoles) of 3,4-diethoxy-1,2,5- thiadiazole-l-oxide in 250 ml of ethanol is added 18.7 g (263 mmoles) of pyrrolidine. The mixture is stirred for 30 minutes at room temperature then concentrated to 1/4 volume and diluted with an equal volume of ether. The reaction mixture is filtered and the filtrate concentrated in vacuo, dissolved in methylene chloride and washed 3 times with dilute hydrochloric acid and twice with a saturated salt solution. The organic layer is dried over anhydrousmaqnesium sulfate and concentrated in vacuo. The oil crytallizes with scratching in ethyl acetate. The solid material is filtered affording 23.5 g of white crystals m.p.=59-620C identified as 3-ethoxy-4-(1-pyrrolidinyl)-1,2,5-thiadiazole-1-oxide. Mass spectrum 215 (M+), 186 (M+ - C2H5), 170 (M -CfH8N), 119 (M - C5H8N2), (C4H8N) -l IR (CHC13) 1625 (C=N), 1125 CM 1 (SO) Proton N.M.R. (CDCl3) 4.5 (t,J=7Hz, 2H) 3.7 (m,4H)2.0 (M,4H) 1.5 (t,J=7HZ 3H). PREPARATION 5 3-Methylthio-4-(4-morpholino)-1,2,5-thiadiazole-1-oxide 1.9 G (10 mmoles) of 3,4-dithiomethyl-l,2,5- thiadiazole-l-oxide and 0.9 ml (10 mmoles) of morpholine are dissolved in 25 ml of acetonitrile and stirred for 30 minutes at room temperature. The reaction mixture is filtered and 500 mg of crystals are obtained which proton nuclear magnetic resonance shows to be the 3-morpholino adduct. 200 Mg of this material is redissolved in 5 ml of acetonitrile and heated at reflux for 1 hour. The reaction mixture is evaporated to dryness and the residue is treated with ether and filtered. The solid material has a melting point of 142-1480C and nuclear magnetic resonance confirms the structure as that of 3-thiomethyl-4 (4-morpholino)-1,2,5-thiadiazole-l-oxide PREPARATION 6 3-Ethoxy-4-amino-l, 2, 5-thiadiazole-l ,1-dioxide To a suspension of 3,4-diethoxy-1,2,5thiadiazole-l,l-dioxide (5.15 g, 25 mmol) in 25 ml of dry CH2C12 is added 4.05 g (25 mmol) of hexamethyldisilazane. The mixture is stirred 18 hours at room temperature under nitrogen and the resulting clear solution is filtered through a short column of silica gel. Elution of the column with 1-4% ethanol-CH2C12 gives fractions containing 3.8 g of pure 3-ethoxy-4-amino-1;2,5-thiadiazole-l,l- dioxide, m.p. 176-1770C. PREPARATION 7 3-Ethoxy-4-amino-1,2,5-thiadiazole-1-oxide To a partial suspension of 28.5 g (0.15 mol) of 3,4-diethoxy-1,2,5-thiadiazole-1-oxide in 75 ml of ethanol at room temperature is added dropwise a solution of 114 ml of ca 1.4 M ammonia in ethanol over a one hour period. Reaction progress is monitored by T.L.C. When about half complete, product begins to crystallize out. The precipitated product is filtered and washed with ethanol to give a white crystalline product, 12.4 g, m.p. 130-134 . Ethanol mother liquor is concentrated to give a second crop. PREPARATION 8 3,4-Diamino-1,2,5-Thiadiazole-l-oxide Into a reaction vessel containing ethanol (300 mls) immersed in a cooling ice bath, there is- added with stirring until a slurry is fdrmed 40.0.g (210 mmols) of 3,4-diethoxy-l,2,5-thiadiazole-l- oxide from preparation 1 above. Excess ammonia gas is slowly bubbled through the slurry for ca. 5 minutes until a clear solution is obtained. The ice bath is then removed and excess ammonia gas is continued to be bubbled through the clear solution for an additional 20 minutes, the rate of bubbling being at a moderate rate for the first 5 minutes and then increased to a rapid rate for the remaining 15 minutes until heavy crystals form. More ethanol (200 mls) is added and rapid bubbling of ammonia gas through the solvent is continued for an additional 5 minutes. The heavy crystals are then filtered, washed with ethanol, and dried (ca. 1 mm) overnight to afford 98.0% of 3,4-amino-1,2,5-thiadiazole- l-oxide; m.p., 3000C. NMR is found to be consistent with the structure. The processes set forth in the foregoing Preparations are employed to obtain the following intermediate compounds of Formula XX: EMI78.1 EMI79.1 <tb> R1 <SEP> R2 <SEP> Melting <SEP> Point <tb> C2H5 - <SEP> -N <SEP> l23-1250C <tb> <SEP> -N <SEP> < <tb> C2H50 <tb> <SEP> -N-CH3 <SEP> l300C <tb> C2H5 - <SEP> -NH2 <SEP> 130-1330C <tb> CH3S <tb> <SEP> -N <SEP> C <SEP> 119-1200C <tb> C2H5 <tb> <SEP> -N <SEP> N-H <SEP> 2180C <tb> CH3S- <SEP> -NH-CH(CH3)2 <SEP> 135-1360C <tb> Similarly, the foregoing Preparations are employed to obtain the following intermediate compounds of Formula XXI: 3-amino-4-methylamino-1,2,5-thiadiazole-1-oxide; 3-amino-4-(2-dimethylaminoethyl)amino-l,2,5-thiadiazole-l-oxide; 3-amino-4-dodecylamino-1,2,5-thiadiazole--1-oxide; 3-amino-4-(4-fluoroanilino)-l,2,5-thiadiazole-l-oxide; 3-amino-4-morpholino-1,2,5-thiadiazole-1-oxide; 3-morpholino-4-(2-pyridinomethyl)amino-l,2,5-thiadiazole-l-oxide; 3,4-diamino-1,2,5-thiadiazole-l-oxide.

Claims: WHAT IS CLAIMED IS: 1. Compounds having the formulae: EMI80.1 EMI81.1 wherein R is hydrogen, loweralkyl: EMI81.2 wherein R3 and R4 are independently hydrogen, loweralkyl, cycloloweralkyl, or phenylloweralkyl, or R3 and R4 may be joined to form, along with the nitrogen to which they are attached, a 5- or 6-membered heterocycle, which may also contain an oxygen, sulfur or N-R7 heteroatom, wherein R7 is hydrogen, loweralkyl of from 1 to 3 carbon atoms or benzyl; R5 and R6 are independently hydrogen or loweralkyl; n is O or 1; m is 2 to 4; k is 1 to 4; X is oxygen, sulfur or methylene; p is 1 or 2; ; R1 and R2 are independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, cycloalkyl, phenyl, pyridyl and substituted loweralkyl wherein the substituent is phenyl, cycloloweralkyl, pyridyl, imidazolyl, morpholino, hydroxy, loweralkoxy, loweralkylthio or di (loweralkyl) amino, or R1 and R2 may be joined to form, along with the nitrogen to which they are attached, a 5- or 6-membered heterocycle which may also contain an oxygen, sulfur or N-R7 heteroatom wherein R7 is as defined above; is is phenylene or a 5- or 6-membered heterocycle containing one to three heteroatoms selected from oxygen, sulfur or nitrogen, which may optionally have a benzo ring fused thereon; provided that when Hz is a 5-membered heterocycle or benzo fused 5-membered heterocycle, n is 1; Ar is aryl; ; R10 is lower alkanoyl, aroyl, substituted aroyl, hetaroyl, lower alkylsulfonyl, arylsulfonyl, hetarylsulfonyl, cyano, amidino, dialkylcarbamoyl, dialkylsulfamoyl, alkoxycarbonyl, - (CH2) yCOR11 wherein y is 1 o 2; R11 is loweralkyl, hydroxy, alkoxy, amino, loweralkylamino, diloweralkylamino; Rl2 is aralkylidene, diarylmethylidene; and, the physiologically acceptable salts thereof. 2. The compounds of Claim 1 which are members selected from the group consisting of: 3-N-t3-[3-(dimethylaminomethylphenoxy3propyleamino-4- amino-1,2,5-thiadiazole-l-oxide; 3-N-[3-(1-piperidinylmethylaphenoxylpropyl3amino-4- amino-1,2,5-thiadiazole-l-oxide; 3-N-[3-[3-(dimethylaminomethyl)phenoxy]propyl]amino-4- methylamino-1,2,5-thiadiazole-1-oxide; 3-N-[3-[3-(dimethylaminomethyl)phenoxypropyl]amino-4- amino-1,2,5-thiadiazole-l,l-dioxide; 3-N-[2-[(2-furanyl)methylthio]ethyl]amìno-4-amino- 1,2, 5-thiadiazole-l-oxide; 3-N-[2-[ (5-dimethylaminomethyl-2-thienyl)methylthio] ethyl] amino-4-amino-l, 2,5-thiadiazole-l-oxide; 3-N-[2-[(4-methyl-5-oxazolyl)methylthio]ethyl]amino-4- amino-1,2,5-thiadiazole-l-oxide; 3-N-[2-[ (2-furanyl)methylthio]ethyl]amino-4-amino- 1,2,5-thiadiazole-1,1-dioxide; 3-N-[2-[[5-(1-piperidinylmethyl)-2-furanyllmethyl- thio]ethyl]amino-4-amino-1,2,5-thiadiazole-1- oxide; 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio] ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide; 3-N-[ 2-t(5-dimethylaminomethyl-2-furanyl)methytthio} ethyl]amino-4-methylamino-1,2,5-thiadiazole-1-oxide; 3-N- [2-[(5-dimethylaminomethyl-2-furanyl)methylthio] ethyl]amino-4-methylamino-1,2,5-thiadiazole-1,1- dioxide; 3-N-[ 2-[(5-dimethylaminomethyl-2-furanyl)methylthio] ethyl]-amino-4-amino-1,2,5-thiadiazole-1,1-dioxide; 3-N- [2- [ (5-methylaminomethyl-2-furanyl)methylthio] ethyl]amino-4-amino-1,2,5-thiadiazole-1-oxide; 3-N-[ 2- E (5-methylaminomethyl-2-furanyl)methylthio] ethyl]amino-4-amino-1,2,5-thiadiazole-1,1-dioxide; 3-N- E2- [ (2-guanidino-4-thiazolyl)methylthio]ethyl] amino-4-methylamino-l,2,5-thiadiazole-l,1-dioxide; 3-N- E 2- E (2-guanidino-4-thiazolyl)methylthio]ethyl] amino-4-amino-1,2,5-thiadiazole-l-oxide; 3-N- [2- E (2-guanidino-4-thiazolyl)methylthio]ethyl] amino-4-methylamino-l,2,5-thiadiazole-l-oxide; and, 3-N- [2-[ E (6-(4-morpholinylmethyl-2-benzofuranyl) methylthio]ethyl]amino-4-amino-1,2,5-thiadiazoLe-l- oxide. 3. Compounds having the formulae: EMI85.1 wherein R, n, X, and m are as defined in Claim 1; p is I or 2; L2 is loweralkoxy, loweralkylthio, phenoxy, phenylthio or halogen; and, the physiologically acceptable salts thereof. 4. The compounds of Claim 3 which are members selected from the group consisting of : 3-N-[2-[(5-dimethylaminomethyl-2-furanyl)methylthio3 ethyl]amino-4-ethoxy-1,2,5-thiadiazole-1-oxíde; 3-N-[2-[ (5-dimethylaminomethyl-2-furanyl)methylthio] ethyl]amino-4-ethoxy-1,2,5-thiadiazole-1,1-dioxide; 3-N-[3-(2-guanidino-4-thiazolyl)phenyl]amino-4-methyl amino-1,2,5-thiadiazole-l-oxide; 3-N-[3-(2-guanidino-4-thiazolyl)phenyl]amino-4-amino- 1,2, 5-thiadiazole-1-oxide; 5. Compounds having the formulae: EMI86.1 wherein R1 and R2 are members selected from the following groups: a) wherein R1 an R2 are the same and are loweralkoxy, loweralkylthio, phenoxy or phenylthio; or, b) wherein R1 and R2 are different and one of R1 or R2 is amino or loweralkylamino and the other is halo or loweralkylthio; or, c) wherein R1 and R2 are different and one of R1 and R2 is as defined in a) above and the other is: EMI86.2 wherein R3 and R4 are independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, cycloloweralkyl, phenyl, pyridyl, or substituted loweralkyl wherein the substituent is phenyl cycloloweralkyl, pyridyl, imidazolyl, morpholino, hydroxy, loweralkoxy, lower alkylthio, di (loweralkyl) amino; or, R3 and R4 may be connected to form , along with the nitrogen to which they are attached, a 5- or 6-membered heterocyclic ring which may also contain an oxygen, sulfur or an N-R5 heteroatom selected from morpholine, thiomorpholine, piperidine, piperazine, N-loweralkyl piperazine, and pyrrolidine wherein R5 is hydrogen or loweralkyl of from 1 to 3 carbon atoms; and, EMI87.1 wherein Rl, R2, R3 and R4 can each independently be hydrogen, alkyl, loweralkenyl, loweralkynyl, cycloloweralkyl, aryl, phenyl, pyridyl or substituted loweralkyl wherein the substituent is amino, phenyl, substituted phenyl, cycloloweralkyl, pyridyl, loweralkoxy, imidazolyl, morpholino, hydroxy, di(loweralkyl)amino; or, R3 and R4 may be connected to form, along with the nitrogen to which they are attached a 5- or 6-membered heterocyclic ring, which may also contain an oxygen, sulfur or N-R5 heteroatom, said heterocyclic ring being a member selected from morpholine, thiomorpholine, piperazine, piperidine, N-loweralkyl-piperazine, and pyrrolidine, and wherein R5 is hydrogen or loweralkyl of from 1 to 3 carbon atoms. 5. Compounds of Claim 5 which are members of the group consisting of: 3,4-diethoxy-1,2,5-thiadiazole-l-oxide; 3, 4-bis-methylthio-l, 2, 5-thiadiazole-l-oxide; 3-methylamino-4-methylthio-1,2,5-thiadiazole-1-oxide; 3-amino-4-methylthio-1,2,5-thiadiazole-1-oxide; 3-isopropylamino-4-methylthio-1,2,5-thiadiazole--L- oxide; 3-ethoxy-4-amino-1 , 2, 5-thiadiazole-l-oxide; 3-ethoxy-4-methylamino-1,2,5-thiadiazole-l-oxide; 3-ethoxy-4-(1-pyrrolidinyl)-1,2,5-thiadiazole-1-oxide; 3-ethoxy-4-(4-morpholino)-1,2,5-thiadiazole-1-oxide; 5 (dimethylaminomethyl) furfuryl mercaptan. 3,4-diamino-1,2,5-thiadiazole-loxide; 3-amino-4-(2-dimethylaminoethyl) amino-l,2,5- thiadiazole-l-oxide; 3-amino-4-methylamino-1,2,5-thiadiazole-1-oxide; 3-amino-4-dodecylamino-1,2,5-thiadiazole-1-oxide;- 3-amino-4-(4-fluoroanilino) -l,2,5-thiadiazole-1-oxide; 3-amino-4-morpholino-l,2,5-thiadiazole-l-oxide; and, 3-morpholino-4-(2-pyridinomethyl)amino-1,2,5- thiadiazole-l-oxide. 7. A process for the preparation of a compound of Claim 1 which comprises treating a compound having the formula: EMI89.1 wherein p is 1 or 2 and L1 and L2 are leaving groups, sequentially with either of the amines: EMI89.2 or R- A -(CH2)n-X-(CH2)m-NH2 wherein R, # n, X, m, R1 and R2 are as defined in Claim 1, followed by treatment of the resulting compound with the other of said amines; or where is is furan, treating the resulting compound with the other of said amines to obtain a furan intermediate compound; reacting said furan intermediate compound with either EMI90.1 wherein Hal is halo and R3 and R4 are as defined in Claim 1 to produce the compounds of Claim 1; or, reacting an intermediate compound having the formula: EMI90.2 wherein R, , X, m, n and p are as defined in Claim 1 and L2 is a leaving group with an imine such as EMI90.3 or (aryl)2C=NH wherein R5 is as defined in Claim 1 to produce derivatives having the formula: EMI90.4 wherein R, Hz , X, m, n and p are as defined in Claim 1; R12 is aralkylidene, diarylmethylidene; or, reacting said intermediate with EMI91.1 wherein R5 is as defined in Claim 1 to produce derivatives having the formula: EMI91.2 wherein R, R5, , X, m, n and p are as defined in Claim 1; and, the physiologically acceptable salts of said compounds and said derivatives. 8. A process for the preparation of compounds of Claim 1 which comprises reacting an alcohol having the formula: EMI91.3 wherein R1, R2 and p are as defined in Claim 1 and m > 2, with an-acylating agent to obtain an activated ester intermediate; reacting said ester intermediate with an alkali metal salt of 3-hydroxy benzaldehyde to obtain an intermediate having the formula: EMI92.1 wherein X is 0; and, reducing said intermediate in the presence of amine R3NHR4, wherein R3 and R4 are as defined in Claim 1; or, reacting said ester intermediate when m=2 with a mercaptan having the formula R- -(CH2)n-SH wherein R, and n are as defined in Claim 1; or reacting an alcohol having the formula R- Hz -(CH2)n-X-CH2CH2OH wherein R, , X and n are as defined in Claim 1 with, after activation of said alcohol toward nucleophiles, an amino compound having the formula: EMI92.2 wherein R1, R2 and p are as defined in Claim 1; or, reacting a mercaptan having the formula: EMI92.3 wherein R1, R2 and p are as defined in Claim 1, with an alcohol having the formula R- -(CH2)n-OH wherein R, G and n are as defined in Claim 1, in the presence of a mineral acid to afford the compounds of Claim 1; and the physiologically acceptable salts thereof; or, reacting the compounds defined in Claim 1 and tautomers thereof with an alkylating reagent, an acylating agent or a sulfonating agent to produce derivatives having the formulae: EMI93.1 (LIB) wherein R, R1, ii) , X, m, n and p are as defined in Claim 1; R10 is lower alkanoyl, aroyl, substituted aroyl, hetaroyl, lower alkylsulfonyl, arylsulfonyl, hetarylsulfonyl, cyano, amidino, dialkylcarbamoyl, dialkylsulfamoyl, alkoxycarbonyl, -(CH2)yCORll wherein y is 1 or 2 and R11 is loweralkyl, hydroxy, alkoxy, amino, loweralkylamino, diloweralkylamino; and, the physiologically acceptable salts thereof. 9. A process for the preparation of compounds of Claim 5 which comprises treating a compound having the formula: EMI94.1 wherein R1 and R2 are as defined in a) or b) in Claim 5, with thionyl chloride in the presence of a base to form a compound having the formula: EMI94.2 which is treated with an amine having the formula: EMI94.3 wherein R3 and R4 is as defined in Claim 5 to form the compounds wherein R1 and R2 are as defined in c) in Claim 5; or, treating a compound having the formula: EMI94.4 wherein L1 and L2 are leaving groups selected from the group consisting of loweralkoxy, loweralkylthio, phenoxy, or phenylthio, with thionyl chloride in the presence of a base to form an intermediate compound having the formula: EMI95.1 which is reacted with amines having the formulae: EMI95.2 wherein R1, R2, R3 and R4 are as defined-in Claim 5 to form the compounds having the formula: EMI95.3 wherein R1, R2, R3 and R4 are-as defined in Claim 5. 10. A method for suppressing gastric acid secretions in an animal with excess gastric acid secretions which comprises administering to said animal an effective amount of a compound of Claimsfl, 3 or 5. 11. A composition useful for suppressing gastric acid secretions in an animal with excess gastric acid secretions which comprises an inert carrier and an effective amount of a compound of Claims 1, 3 or 5.

Inventors: AMATO, JOSEPH S., BALDWIN, JOHN J., BOLHOFER, WILLIAM A., KARADY, SANDOR, LUMMA, WILLIAM C., WEINSTOCK, LEONARD M.
Applicants: MERCK & CO. INC.
Application year: 1981
Main classification: C07D417
IPC codes: C07D295, C07D277, C07D213, C07D307, C07D285