SUBSTITUTED 2-HYDROXYPHENYL CYCLOALKANES AND PHARMACEUTICAL COMPOSITIONS THEREOF

Abstract: Compounds are disclosed having the formula R₁ is hydrogen, benzyl or an ester moiety; Y is -CH(R₂″)CH(R₂)- or -CH(R₃)CH₂-; R₂″ is hydrogen or methyl; R₂ is OH or X-substituted (C₁₋₆)alkyl; R₃ is OH, cyano or X-substituted (C₁₋₃)alkyl; X is -OR₆, -SR₆, -S(O)R₆, -S(O)₂R₆, -NR₆R₇, -COOR₇, -CONR₇R₈ or oxo; with the proviso that when X is -NR₆R₇, -COOR₇ or -CONR₇R₈, said group is located on the terminal carbon atom of R₂ or R₃; R₆ is hydrogen, (C₁₋₆)alkyl or acetyl, with the provisos that, when R₆ in -NR₆R₇ is acetyl, R₇ is hydrogen, and R₆ in S(O)R₆ and S(O)₂R₆ cannot be acetyl; each of R₇ and R₈ is hydrogen or (C₁₋₆)alkyl; s is an integer of 1 or 2; and Z-W is alkyl or oxaalkyl having 5 to 13 carbon atoms, or phenyl- or pyridyl-alkyl or -oxaalkyl having 3 to 8 carbon atoms in the alkyl or oxaalkyl group. Pharmaceutical compositions of such compounds, other than those in which is mandeloyl or R₁ is benzyl, are useful as analgesic or CNS agents and as anti-emetic agents.

Description: SUBSTITUTED 2-HYDROXYPHENYL CYCLOALKANES AND PHARMACEUTICAL COMPOSITIONS THEREOF This invention relates to novel 3-[2-hydroxy-4 (substituted)phenyl]-4(or 5-)-Bubstituted)cycloalkanones, cycloalkanols, cycloalkylamines and cycloalkanes, useful as analgesic agents and as anti-emetic agents; to derivatives thereof, intermediates therefore and processes for their preparation. Despite the current availability of a number of analgesic agents, the search for new and imProved agents useful for the control of broad levels of pain and accompanied by a minimum of side-effects continues. The most commonly used agent, aspirin, is of no practical value for the control of severe pain and is known to exhibit various undesirable side-effects. Other analgesic agents, such as meperidine, codeine, and morphine, possess addictive liability. The need for improved and potent analgesic agents is, therefore, evident. Compounds having utility as analgesics, tranauilizers, sedatives, antianxiety agents and/or as anticonvulsants, diuretics and antidiarrheal agents are described in Belgian Patents 870,404 and 870,402, both granted March 12, 1979. Belgian Patent 870,404 describes 3-[2-hydroxy-4-(substituted)phenyl]cycloalkanones and cycloalkanols which may have at the 4-position of the cycloalkanone or cycloalkanol residue, an alkyl, alkenyl, phenyl or phenylalkyl substituent; or, at the 5-position, an alkyl substituent, and Belgian Patent 870,402 discloses certain 2- (acyclic substituted)phenols; namely, 2 (hydroxyalkyl)-4- (substituted)phenols and 2-(oxoalkyl) 4- (substituted) phenols. U.S. Patent 3,576,887, issued April 27, 1971, discloses a series of l-(l'-hydroxy)alkyl-2-(ohydroxyphenyl)cyclohexanes which exhibit central nervous system depressant properties. U.S. Patent 3,974,157 describes 2-phenylcyclohexanones which can be substituted in the phenyl ring with up to two alkyl, hydroxy or alkoxy groups as intermediates for preparation of l-(aminoalkyl)-2-phenylcyclohexanols useful as analgesics, local anesthetics and antiarrhythmics. Chemical Abstracts 85, 176952f (1976) discloses a number of 3-phenyl- and 3-phenylalkylcyclohexanones as intermediates for 2-aminomethyl-3-phenyl (or phenylalkyl)cyclohexanones which exhibit analgesic, sedative, antidepressant and anticonvulsant activities. The compounds of this invention have the formulae EMI3.1 wherein R is hydrogen, hydroxy1 mandeloyloxv, alkanoyloxy having from one to five carbon atoms, amine or acetamido; R1 is hydrogen, benzyl, alkanoyl having from one to five carbon atoms, P(O) (OH)2 and mono- and disodium and potassium salts thereof, -CO(CH2)2CCOH and the sodium and potassium salts thereof, or -CO(CE2)D5R4Rs wherein p is 0 or an integer from 1 to 4, each of R4 and R when taken individually is hydrogen or alkyl having from one to four carbon atoms; R4 and R when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring (piperidino, pyrrolo, pyrrolidino, morpholino and N alkylpiperazino having from one to four carbon atoms in the alkyl group); s is an integer of 1 or 2; y is -CH(R2")CH(R2)- or CH(R3)CH2; R" is hydrogen or methyl; R2 is hydroxy or X-substituted alkyl having from one to six carbon atoms; R3 is hydroxy, cyano or X-substituted alkyl having from one to three carbon atoms; X is -OR6, -NR6R7, -COOR7, -CONR7R8 or oxo; R6 is hydrogen, alkyl having from one to six carbon atoms, acetyl or mandeloyl; ; each of R7 and R8 is hydrogen or alkyl having from one to six carbon atoms; provided that when X is -NR6R7, -COOR7 or -CONR7R8, it is located on the terminal carbon atom of R2 or R3; and when R6 in -MR6R7 is acetyl, R7 is hydrogen; W is hydrogen, pyridyl or EMI4.1 wherein W1 is hydrogen, chloro or fluoro, provided that when W is hydrogen, Z is (a) alkylene having from five to thirteen carbon atoms; or (b) (alk1)mO(alk2)n wherein each of (alk1) and (alk2) is alkylene having from one to thirteen carbon atoms; each of m and n is 0 or 1; with the provisos that the summation of carbon atoms in (alk1) plus (alk2) is not less than five or greater than thirteen; and at least one of m and n is 1; when W is other than hydrogen, Z is (a) alkylene having from three to eight carbon atoms; or (b) -(alk1)m-o-(alk2)n wherein each of (alkl) and (alk2) is alkylene having from one to eight carbon atoms; each of m and n is 0 or 1; with the provisos that the summation of carbon atoms in (alk1) plus (alk2) is not less than three or greater than eight; and at least one of m and n is 1; In each of formulae I and II, the Y variable is positioned in the cycloalkyl moiety in such manner that R2 is always a 4-position substituent and each of R2" and R3 is always a 5-position substituent. Also included in this invention as noted above are the pharmaceutically acceptable acid addition salts of those compounds of fourmulae I and II which contain one or more basic groups. Typical of such compounds are those wherein the W variable is pyridyl and/or OR1 represents a basic ester moiety; R2 is aminoalkyl; R is amino. In compounds having more than one basic group present, polyacid addition salts are, of course, possible. Representative of such pharmaceutically acceptable acid addition salts are the mineral acid salts such as the hydrochloride, hydrobromide, sulfate, phosphate, nitrate; organic acid salts such as the citrate, acetate, sulfosalicylate, tartrate, glycolate, malate, malonate, maleate, pamoate, salicylate, stearate, phthalate, succinate, gluconate, 2-hydroxy-3-naphthoate, lactate, mandelate and methanesulfonate. Compounds of formula II wherein R1 is hydrogen exist, in solution, in equilibrium with their hemiketal forms. The keto and hemiketal forms of said compounds of formula II are included in this invention. Compounds of formulae I and II contain asymmetric centers at the 3-, the 4- and the 5-positions in the cycloalkyl moiety and may, of course, contain additional asymmetric centers in (-Z-W) of the phenyl ring. Formula I compounds, of course, contain an astretric center at the l-position when R is other than hydrogen. Cisrelationship between the substituent at the 1-position of the cycloalkyl moiety and the phenolic, or substituted phenolic, moiety at the 3-position of formula I is favored, and trans-relationship between the 3- and 4substituents and the 3- and 5-substituents on the cycloalkyl moiety are favored because of the greater (quantitatively) biological activity. For the same reason, the trans-3,4 and 3,5-relationship is also favored in compounds of formula II. For convenience; the above formulae depict the racemic compounds. However, the above formulae are considered to be generic to and embracive of the racemic modifications of the compounds of this invention, the diastereomeric mixtures, the pure enantiomers and diastereomers thereof. The utility of the racemic mixture, the diastereomeric mixture as well as of the pure enantiomers and diastereomers is determined by the biological evaluation procedures described below. Favored because of their greater biological activity relative to that of other compounds described herein are compounds of formulae I and II wherein each of R is hydroxy or acetamido; R1 is hydrogen; R2" is hydrogen or methyl; each of R2 and R3 is hydroxyalkyl, alkoxyalkyl, carboalkoxyalkyl or dialkylaminoalkyl; and Z and W have the values shown below: EMI6.1 <tb> <SEP> Z <SEP> m <SEP> n <SEP> w <tb> C7-ll <SEP> alkylene <SEP> --- <SEP> H <tb> C4-7 <SEP> alkylene <SEP> --- <SEP> - <SEP> zW1 <SEP> pyridyl <tb> <SEP> -(alsscl)m¯ ¯(alk2)n <SEP> 0,1 <SEP> 1 <SEP> w1, <SEP> pyridyl <tb> each of (alk1) and (alk2) is C17 alkylene with the proviso that the summation of carbonatoms in (alk1) plus (alk2) is not less than four or greater than seven; (alk1)m-o-(alk2)n- 0,1 1 H each of (alkl) and (alk2) is C1-11alkylene with the proviso that the summation of carbonatoms in (alk1) plus (alk2) is not less than seven or greater than eleven. preferred compounds of formulae I and II are those favored compounds wherein: each of R2" and R1 is hydrogen; Z is C(CH3)2(CH2)6 and W is hydrogen; z is C47 alkylene and W is phenyl; Z is -O-alkylene having 7 to 9 carbon atoms and W Is hydrogen; z is -O-alkylene having from 4 to 5 carbon atoms and W is phenyl; R of formula I is hydroxy (cis- and trans-forms); R2=@-hydroxy (C2-4)alkyl or #-methoxy (C2-4)alkyl; R3 = hydroxyalkyl or methoxyalkyl. Especially preferred are compounds of formulae I and II wherein R, R1, Z and W are as defined for the preferred compounds; R2 is 3-hydroxypropyl or 3-methoxypropyl; and R3 is hydroxymethyl. The l-form of a given compound is preferred over the d-form thereof. The compounds of this invention having formulae I or II wherein Y is -CH(R2")CH(R2)- are prepared from the appropriate 2-bromo-5-(Z-W substituted) phenol by a series of reactions which comprises as the first step protection of the phenolic group. Suitable protecting groups are those which do not interfere with the subsequent reactions and which can be removed under conditions which do not cause undesired reactions at other sites of said compounds or of products produced therefrom. Representative of such protective groups are those phenolic protecting groups described by Haslam in Chapter 4 of "Protective Groups in Organic Chemistry," dited by J.F.W. McOmie, Plenum Press, London and New York (1973). Favored groups are methyl, ethyl, tetrahydropyranyl, benzyl or substituted benzyl wherein the substituent is, for example, alkyl having from one to four carbon atoms, halo (C1, Br, F, I) and alkoxy having from one to four carbon atoms. The ether protecting, or blocking, groups can be removed through the use of hydrobromic acid in acetic acid or hydrobromic acid, 48% aqueous. The reaction is conducted at elevated temperatures and desirably at the reflux temperature. However, when Z is -(alkl)z-O-(alk2)n-, acids such as polyphosphoric acid or trifluoroacetic acid must be used to avoid cleavage of the ether linkage. Other reagents such as hydriodic acid, pyridine hydrochloride or hydrobromide can be used to remove protecting ether groups such as methyl or ethyl groups. When the protecting groups are benzyl or substituted benzyl groups, they can be removed by catalytic hydrogenolysis. Suitable catalysts are palladium or platinum, especially when supported on carbon. Alternatively, they can be removed by solvolysis using trifluoroacetic acid. A further procedure comprises treatment with n-butyllithium in a reaction-inert solvent at room temperature. Particularly valuable compounds of the invention are those of the formulae: EMI8.1 or EMI8.2 where R1 is hydrogen or benzyl and R6 is hydrogen or methyl, or a diastereomeric bis-d-mandelate thereof, except when R6 is methyl, EMI8.3 EMI8.4 Particularly valuable intermediates for such compounds are the diastereomeric d-mandelates of compounds of the formula EMI8.5 where R1 is benzyl and s is 1 or 2. The exact chemical structure of the protecting group is not critical to this invention since its importance resides in its ability to perform in the manner described above. The selection and identification of appropriate protecting groups can easily and readily be made by one skilled in the art. The suitability and effectiveness of a group as a hydroxy protecting group are determined by employing such a group in the herein-illustrated reaction sequences. It should, therefore, be a group which is easily removed to regenerate the hydroxy groups. Methyl, tetrahydropyranyl and benzyl are preferred protecting groups since they are readily removed. The protected 2-bromo-5-(Z-W substituted) phenol is then reacted with magnesium in a reaction-inert solvent and generally in the presence cf a promoter, e.g., cuprous salts such as the chloride, bromide and iodide (to promote 1,4-addition) with the appropriate 4-R2t-2-cycloalken-1-one (e.g., 4-R2 '-2-cyclohexen-1- one) wherein R2' is alkenyl or X'-substituted alkyl wherein X1 is X or a precursor therefor, e.g., -Obenzyl as precursor for -OH; -CH(OCH3)2 or -RCOCH2CH2O as precursor for -C HO. Suitable reaction-inert solvents are cyclic and acyclic ethers such as, for example, tetrahydrofuran, dioxane and dimethyl ether of ethylene glycol (diglyme). The Grignard reagent is formed in known manner, as, for example, by refluxing a mixture of one molar proportion of the bromo reactant and two molar proportions of magnesium in a reaction-inert solvent, e.g., tetrahydrofuran. The resulting mixture is then cooled to about 0 C. to -200 C. The amount of cuprous iodide used is not critical, but can vary widely. Molar proportions ranging from about 0.2 to about 0.02 moles per mole of bromo reactant afford satisfactory yields of the cycloalkanone wherein the phenolic hydroxy group is protected (formula II, R1 = a protecting group). Alternatively, compounds of formulae I and II are prepared by reaction of the copper derivative of an appropriate 3-(Z-W-substituted)phenol, the hydroxy group of which is suitably protected, with an appropriate 4or 5-substituted cycloalk-2-en-1-one in a reactioninert solvent at a low temperature, e.g., below -2O0C. Suitable protecting groups are those enumerated above except, of course, benzyl or substituted benzyl which would be removed during preparation of the precursor lithio derivative of the copper 3-(Z-W)phenol. An especially useful protecting group for this alternative methodology is the tetrahydropyranyl group. Said protecting group is easily introduced into the phenol reactant, is stable to the conditions of subsequent reactions in which said protected compound serves as intermediate, and is conveniently removed by hydrolysis. The copper derivative of the 3-(Z-W-substituted)- phenol is prepared -from the lithio derivative of said phenol by treatment of said lithio derivative with 1hexyne copper. It undergoes 1,4-addition to the conjugated C=C-C=O system of the cycloalk-2-en-1-one reactant, in contrast to the characteristic 1,2-addition of the corresponding lithio derivative. This alternative 1,4-addition step, of course, gives rise to the same compounds as does the abovedescribed Grignard reaction. It generally affords better yields the formulae II and I compounds It will be noted that in a preparation of a compound of formula I herein wherein each of R and R1 is hydroxy, Y is -CH2CHR2-, R2 is (CH2)3OH and Z-W is 1,1dimethylheptyl, the particular sequence exemplified (Examples 72-74 utilizes intermediates wherein the Z-W group is 1,l-dimethyl-2-heptenyl and which is hydrogenated in the last step of the sequence to 1,1dimethylheptyl. Reduction of said l,1-dimethyl-2- heptenyl group can, of course, be accomplished at any stage of the sequence if desired, i.e., it need not be delayed until the final step. The protected cycloalkanone is then treated with an appropriate reagent to remove the protecting group, if desired. The benzyl group is conveniently removed by the method described above. If the protecting group is an alkyl group (methyl or ethyl), it is removed by the above-mentioned methods or by treatment with, for example, pyridine hydrochloride. The tetra- hydropyranyl group is removed by means of an acidic reagent. When the appropriate 4-R2'-2-cycloalken-1-one is not available or is not readily obtainable by known methods, compounds of formula II wherin R2 is oxosubstituted (C16)alkyl, and especially those wherein R2 is formyl, serve as intermediates for all other formulae I and II compounds. When R2' is an alkenyl group, the cycloalkanones (formula II) thus produced serve as intermediates for preparation of the corresponding cycloalkanones wherein R2 is substituted alkyl as defined above. The cycloaikanol compounds having formula I are prepared from the protected cycloalkanones by reduction. Sodium borohydride is favored as reducing agent in this step since it not only affords satisfactory yields of the desired product, but retains the protecting group on the phenolic hydroxy group, and reacts slowly enough with hydroxylic solvents (methanol, ethanol, water) to permit their use as solvents. Temperatures of from about 400 C. to about 30 C. are generally used. Lower temperatures, even down to about -700 C., can be used to increase selectivity of the reduction. Higher temperatures cause reaction of the sodium borohydride with the hydroxylic solvent. If higher temperatures are desired, or required for a given reduction, isopropyl alcohol or the dimethyl ether of diethylene glycol are used as solvents. Sometimes favored as reducing agent is potassium tri-sec-butyl borohydride since it favors stereo selective formation of the trans-1,3-phenylcycloalkanol. The reduction is conducted in dry tetrahydrofuran at a temperature below about -500C. using equimolar quantities of the ketone compound and reducing agent. Reducing agents such as lithium borohydride, di isobutylaluminum hydride or lithium aluminum hydride which can also be used, require anhydrous conditons and non-hydroxylic solvents, such as 1,2-dimethoxy- ethane, tetrahydrofuran, diethyl ether, dimethyl ether of ethylene glycol. The cycloalkanols of formula I here OR1 is hydroxy can, of course, be obtained directly by catalytic reduction of the protected cycloalkanone over palladium-on-carbon or by catalytic reduction or chemical reduction of the unprotected cycloalkanone (formula II, OR1 = OH) using the reducing agents described above. In actual practice,it is preferred to produce the unprotected cycloalkanols of formula I (OR1 = OH) via reduction of the benzyl protected cycloalkanones (OR1 benzyloxy) as described above, since it permits stereochemical control of the reduction and formation of the cis-hydroxy epimer as the major product and thus facilitates separation and purification of the epimeric alcohols. Compounds wherein R2' is alkenyl are transformed to corresponding hydroxyalkyl derivatives via hydroboration-oxidation using borane in tetrahydrofuran or diethyleneglycol dimethyl ether (diglyme) at 00 to SO0 C. The intermediate borane product is not isolated but is directly oxidized with alkaline hydrogen peroxide to the alcohol. The alcohols thus produced correspond to anti-Markovnikov addition of the elements of water to the double bond. Further, hydroxyalkyl derivatives can also be produced by oxymercuration-demercuration using mercuric acetate in water followed by reduction (sodium borohydride) of the intermediate hydroxy mecurial derivative. The reaction is carried out at ambient temperature sing an aqueous mercuric acetate/tetrahydrofuran medium. The intermediate is not separated, but is reduced in situ to the alcohol. Addition occurs opposite to that of the hydroboration-oxidation reaction; namely, Markovnikov addition, the elements of water being added to the double bond in a manner opposite to that of the hydroboration-oxidation reaction to produce secondary alcohols. The alcohols serve as intermediates for production of corresponding aldehydes and ketones (oxoalkyl compounds) by oxidation with a suitable oxidizing agent such as pyridinium chlorochromate. The resulting oxo compounds in turn serve as intermediates for increasing the chain length of R2 or R3 alkyl groups having said oxo functionality and, of course, for introducing branching into said alkyl group. The Wittig reaction, using the appropriate ylide, serves admirably for this purpose. For example, reaction of an oxoalkyl group with triphenylphosphonium methylide converts the oxo group to a methylene (= CH2) group. Hydroborationoxidation, affords a primary or secondary alcohol, itself a useful intermediate. Formulae I and II compounds wherein R2 or R3 is oxo substituted alkyl are conveniently prepared by oxidation of corresponding compounds wherein R2' or R3 is an alkenyl group having one more carbon atom than R2 or R3. Sodium metaperiodate and a catalytic amount of osmium tetroxide in aqueous tetrahydrofuran or dioxane at ambient temperature is favored as oxidizing agent since it tends to minimize oxidation beyond the aldehyde stage. However, despite its relative mildness as an oxidant compared to, for example, sodium metaperiodate/ potassium permanganate, some oxidation to the corresponding acid and the corresponding hydroxy ketone does occur. They can also be prepared by Grignard reaction of the appropriate 4-(acetal or ketal substituted alkyl)2-cycloalken-l-one with the appropriate 2-bromo 5-(Z-W substituted) phenol according to the procedure described above. The acetal or ketal group is then transformed by treatment with acid, e.g., a mineral acid such as HCI, to the oxo group. A favored procedure for preparation of compounds of formulae I and II wherein Z-W is -O-(alk2) -w comprises selective alkylat-non of the appropriate 3-(2,4-dihydroxyphenyl)-4-{R2!-substituted)-2-cyclo- alkan-l-one in a reaction-inert solvent according to the procedure described below. The 3-(2,4-dibenzyloxyphenyl)-4-(R2'-substituted) -cycloalkanone is first, if no transformations are to be carried out on the R2'group, debenzylated via hydrogen over palladium-oncharcoal to the corresponding 3- (2, 4-dihydroxyphenyl) -4- (R2 1-substituted) cycloalkanone and then converted to a ketal. Ketal formation is accomplished according to wellknown procedures for ketalization, such as reaction of said 3-(2,4-dihydroxyphenyl)cycloalkanone with an alcohol, especially an alcohol having from one to four carbon atoms, in the presence of an acid, such as sulfuric acid, p-toluenesulfonic acid, hydrogen chloride, under conditions which remove the by-product water. A favored procedure comprises reaction of said 3-(2,4 dihydroxyphenyl)cycloalkanone with an orthoformic ester in solution in an alcohol corresponding to the alcohol moiety of the orthoformic ester. Trimethyl orthoformate and methanol are favored reactants along with concentrated sulfuric acid, anhydrous hydrogen chloride, or ammonium chloride as catalyst. The ketal thus produced is then alkylated by reaction with an appropriate alkylating agent such as W-Z-X'' wherein W and Z are as defined above, and X is selected from the group consisting of chloro, bromo, mesyloxy (CH3-S02-O) and tosyloxy 3-C a 6H4-S02-O) in the presence of an acid acceptor, e.g., sodium or potassium carbonate. The alkylated ketal is then deketalized by treatment with aqueous acid according to known procedures. The 3-[2-hydroxy-4-(-o-(alk2)-W-substituted) phenyl] 4-(R'-substituted)cycloalkanones thus produced are converted to corresponding cycloalkanols by procedures described above. When transformations are to be conducted on group R21 as precursor to group R2, e.g., alkenyl to hydroxyalkyl; -CH(OCH3)2 to -CHO; the desired transformations are carried out prior to removal of the protective, i.e., benzyl groups. For example, when R2' is alkenyl, said group is hydrated via the hydroboration-oxidation procedure described above, either by direct conversion from the 3-(2,A-dibenzyloxyphenyl)- 4-(2-propenyl)cycloalkanone, or by first converting the ketone to a ketal, followed by hydration of the propenyl group and then deketalization. Formula I and II compounds wherein R2 is oxo substituted alkyl serve as intermediates for preparation of oxo substituted alkyl derivatives having increased chain length via the Wittig reaction. A representative procedure comprises, for example, reacting an appropriate 2-(1,3-dioxolan-2-yl)alkyl triphenylphosphonium bromide at about lO4C. to about 80 C. with sodium dimsylate in dimethyl sulfoxide to generate the corresponding ylide in situ. To the thus produced ylide is then added an appropriate reactant such as 3 (2-benzyloxy-4-(Z-W substituted)phenyl-4-(2-oxoethyl)cycloalkanone ethylene ketal in a suitable solvent such as dimethyl sulfoxide at a temperature of from about 100C. to about 800C. The product, a 3-(2benzyloxy-4- (Z-W substi.uted)phenyl)-4-(X-oxoalk- 2-enyl)cycloalkanone bis ethylene ketal, is recovered by known methods such as extraction and column chromatography on silica gel. In this Wittig redaction, the oxo group of the cycloalkanone moiety is protected by conversion to a ketal. If desired, the product is subjected to acid hydrolysis to regenerate the oxo groups. However, when the product is to be subjected to further reactions, it is advantageous to retain the bis ethylene ketal protecting groups on the product. Reduction of the protected (#-oxoalkenyl) group (R2) of the thus produced compour.ds using catalytic hydrogenation over a noble metal catalyst, e.g., Pd/C, affords the corresponding protected (X-oxoalkyl) compound. Treatment of the reduced product with aqueous acid (HC1) as described herein provides the -oxoalkyl derivative of formula II wherein R2 is o-oxoalkyl. Sodium borohydride reduction affords a formula I compound wherein R2 is w-hydroxyalkyl and R is hydroxy. The u-hydroxyalkyl group can be converted to an ether group by the Williamson Synthesis which comprises converting the alcohol to an alkali metal alkoxide followed by alkylation of said alkoxide with an alkyl halide or alkyl sulfate. Formation of a secondary alcohol group in R2 is readily achieved by Grignard reaction on an appropriate compound of formula II, the 1-oxo group of which is protected as an alkylene ketal, and in which R2 is oxoalkyl. Compounds wherein R2 is carjoalcxy substituted alkyl are prepared via the Wittig reaction using the appropriate protected compound of formula II wherein R2 is oxo substituted alkyl; i.e., an aldehyde or ketone group, and a trialkyl phosphonoacetate such as trimethyl or triethyl phosphonoacetate. The reaction is carried out in a reaction-inert solvent such as diethyl ether or tetrahydrofuran at ambient temperature using about one mole of aldehyde reactant to two moles of trialkyl phosphonoacetate. A proton acceptor such as sodium hydride, about ten mole per cent in excess of the trialkyl phosphonoacetate is used. The alpha, beta-unsaturated carboxylic ester thus produced is then reduced, for example, by catalytic hydrogenation over Pd/C to provide the desired carboalkoxyalkyl derivative. Alternatively, said compounds are produced by using a carboalkoxymethylene triphenylphosphorane in place of a trialkylphosphonoacetate. In such instances, the reaction is conducted in a reaction-inert solvent such as diethyl ether, tetrahydrofuran or methylene chloride at from about 200 C. to 800 C. A proton acceptor, e.g., n-butyllithium or phenyllithium is generally used. The alpha, beta-unsaturated carboxylic ester thus produced is reduced as before to give the formula I compound wherein R2 is carbalkoxyalkyl. Hydrolysis, more desirable, saponification, using dilute (e.g., 6N) sodium hydroxide at reflux, followed- by acidification, affords the corresponding carboxyalkyl compound. Compounds wherein R2 is carbamoylalkyl or substituted carbamoylalkyl are prepared in like manner using the appropriate carbamoylmethylenetriphenylphos- phorane in a reaction-inert solvent such as methylene chloride at reflux to provide the alpha, beta-unsatW-ated carboxylic acid amide which is then reduced (H21 Pd/C) to the corresponding carbamoylalkyl derivative. By choice of the appropriate oxoalkyl derivative of formula I, carbalkoxyalkyl and carbamoylalkyl derivatives of varying chain length are produced. Alternatively, said carbamoylalkyl derivatives are prepared by ammonolysis of the corresponding carbalkoxyalkyl derivative with the appropriate amine, HNR7R8, in a reaction-inert solvent. The temperature of the reaction depends upon the ester and amine reactants but ranges from room temserature to the reflux temperature of the solvent. In certain instances, the use of sealed tubes and elevated (e.g., reflux) temperatures are beneficial. However, satisfactory conditions for a given reaction are readily determined by simple experimentation. Representation solvents for this reaction are water, C14 alcohols and excess of the chosen amine. Still further, the carbamoylalkyl derivatives are prepared from corresponding carboxyalkyl derivatives via conversion of said derivatives to acid chlorides by reaction with thionyl chloride, phosphorous pentachloride or trichloride. Reaction with thionyl chloride is favored since the by-products are gaseous and easily removed. In general, excess thionyl chloride is used to serve as solvent as well as reactant and the reaction carried out at a temperature of 200 - 1000C. Acylation of the appropriate amine (HNR7R8) in a suitable solvent, e.g., water, by the Schotten-Baumann method; or in non-aqueous systems, e.g., tetrahydrofuran, dioxan, methylene chloride, in the presence of a tertiary amine (triethylamine, N-methylaniline). in either case, a temperature of from about 0 to about S00C. is used. Formula II compounds wherein Y is -CH(OH)CH2- or -CH2CH(OH)- are prepared from the appropriate 5-[2-(R1O substituted)-4-(Z-W substituted)phenyl]-2-cyclohexen-lone, 6[2-(R1O substituted)-4-(Z-W substituted)phenyl] -3-cyclohepten-l-one, or 3-[2-(R1O substituted)-4-(Z-W substituted)phenyl]-3-cycloalken-l-one to form the corresponding epoxy-cycloalkan-l-one, followed by reduction (hydrogenation) of the epoxide. Compounds of formulae I and II wherein Y is -CH(R3)CH2- are prepared from the appropriate 4-[2benzyloxy-4-(Z-W substituted)phenyl]-2-cycloalken-l-ones, the preparation of which, via the previouslv described Grignard reaction, is described in Belgian Patent 870,404, published March 12, 1979. Nucleophilic addition of the elements of HCN to said 2-cycloalken-l-one compounds by reaction thereof with aqueous sodium or potassium cyanide affords the corresponding trans-3- [2-benzyloxy-4- (Z-W substituted)phenyl]-5-cyano cycloalkanones which are valuable intermediates. Reduction of the oxo group of the cycloalkanone moiety by means of sodium borohydride yields the corresponding trans-cis hydroxy compound. It is converted to the corresponding trans-trans compound by refluxing in t-butanol solution in the presence of potassium t-butoxide. The stereoisomeric cis-3 [2-benzyloxy-4- (Z-W sub stituted) phenyl] -ci S- 5-cyanocycloalkanols are prepared by oxidation. of the trans-trans stereoisomers using, for example, Jones' reagent followed by sodium borohydride reduction of the thus-produced cis-3-[2benzyloxy-4-(Z-W substituted) phenyl]-5-cyanocycloalkanone. Each of the above-mentioned 5-cyanocycloalkanol derivatives is also a valuable intermediate. The cyano group is readily converted by reduction with diisobutyl aluminum hydride (DIBAL-H) to the corresponding formyl derivative. The procedure comprises reacting the cyano derivative with DIBAL-H, two equivalents, in toluene at a low temperature, e.g., 0 C. to -650 C.,. followed by treating the reaction with dilute acid, e.g., a mineral acid such as sulfuric acid. The formyl derivative is recovered by standard procedures such as extraction with ether and evaporation of the solvent. Reduction of the formyl derivative, e.g., by sodium borohydride, affords the corresponding hydroxi-methyl derivative. In the above reactions the benzyl ether derivative of the 3-(2-hydroxy 4- (Z-W substituted)phenyl) 5-cyanocycloalkanol is used as reactant in order to avoid reactions at the phenolic hydroxy group. The protecting benzyl group is removed by methods described above. The 5-hydroxymethyl and 5-formyl derivatives serve as intermediates to other values of R3 by means of the reactions described above as regards conversion of hydroxyalkyl and oxoalkyl values of R2. Formula I compounds wherein R is hydrogen are prepared from the corresponding compounds of formula II by first converting the oxo group to a hydrazone (or semicarbazone) and then decomposing said hydrazone (or semicarbazone) by alkali such as sodium or potassium hydroxide, to produce the corresponding hydrocarbon derivative. The process is readily carried out by heating a mixture of the appropriate cycloalkanone compound and hydrazine hydrate in a reaction-inert solvent such as ethylene glycol or triethylene glycol at 100 C. Solid potassium (or sodium) hydroxide is then added and the mixture heated at an elevated temperature, e.g., 1500- 2000 C. It is then cooled, acidified and the product recovered by known methods, e.g., by extraction with ether. Compounds of this invention wherein R2 or R3 is amino substituted alkyl are prepared from the correspond ing compounds wherein R2 or R3 are oxo substituted alkyl. One procedure comprises converting the appropriate oxo compound of formula I or II to the corresponding oxime or oxime derivative; e.g., an alkyl ether or an acetic derivative, followed by reduction of the oxime or derivative thereof to the desired amine. Of course, when a compound OL ormula II is used as reactant, the 1-oxo group must be protected to avoid reaction at that site unless introduction of an amino group at said site is also desired. The ketal group is a preferred protecting group because of the ease of preparation of said compounds and the relative ease of removal of said group to re generate the oxo group. The oximes of formulae I and II compounds wherein R2 or R3 is oxo substituted alkyl are prepared by reacting said compounds with hydroxylamine hydrochloride in a solution of methanol-water at room temperature. In practice, it is preferred to use an excess of hydroxyl amine, up to as much as a three fold excess. Under such conditions the preparation of the desired oxime deriva tive is complete in 1 to 2 hours. The product is isolated by addition of the reaction mixture to water followed by basification to pH 9.5 and extraction with a water immiscible solvent such as ethyl acetate. The oxime or oxime derivative is then reduced catalytically using, for example, Raney nickel, palladium-on-charcoal or platinum oxide at an initial hydrogen pressure of about 2-3 atmospheres at ambient temperature in a reaction-inert solvent such as C14 alkanol, or lithium aluminum hydride in a reactioninvert solvent such as tetrahydrofuran at reflux temperature. A still further procedure comprises the Gabriel synthesis in which potassium phthalimide is reacted with a compound of formula I or II wherein R2 or R3 is halo (Br, 1)alkyl and the resulting phthalimide derivative hydrolyzed with a base such as sodium or potassim hydroxide or hydrazine. The halo alkyl compounds of fornulae I and II are prepared by reaction of the corresponding hydroxy compound with the appropriate phosphorous halide or hydrogen halide. A favored procedure for preparing said amino corripounds comprises condensation of the appropriate formula I or 1I compound wherein R2 or R3 is oxosubstituted alkyl with the ammonium salt of a lower alkanoic acid and subsequent reduction of the in situ generated imine. In addition to lower alkanoic acid ammonium salts, ammonium salts of inorganic acids can also be used in this procedure. In practice, a solution of the appropriate oxoalkyl compound in a lower alkanol such as methanol is treated with an ammonium-saIt of an alkanoic acid such as acetic acid and the cooled reaction mixture treated with the reducing agent sodium cyanoborohydride. The reaction is allowed to proceed at room temperature for several hours, and is subsequently hydrolyzed and the product isolated. Although stoichiometric proportions of ketone and ammonium alkanoate are required, it is advantageous to use up to a ten fold excess of ammonium alkanoate in order to ensure rapid formation of the imine. It is also advantageous to conduct the reduction at ambient temperature and to use two moles of sodium cyanoborohydride per mole of ketone reactant in order to maximize the yield of the final product. Reaction is complete in 2-3 hours. Reduction of the imine can, of course, be carried out with other reducing agents such as palladium-oncharcoal. In practice, a solution of the appropriate ketone in a lower alkanol, such as methanol or isopropanol, is treated with an ammonium alkanoate, such as ammonium acetate, and 10% palladium-on-charcoal, and the resulting suspension shaken in a hydrogen atmosphere at temperatures of about 250 - 500 C. until the theoretical amount of hydrogen has been absorbed. It is preferred that a 10 fold excess of the =monium alkanoate be employed to ensure complete reaction in a reasonable time period. The amount of the catalyst can vary from 10% to 50% on a weight basis, of the starting ketone. The initial pressure of the hydrogen is not critical, and a pressure from one to fifty atmospheres is preferred to shorten the reaction time. Employing the aforementioned parameters, the reaction time will vary between 2 to 6 hours. Upon completion of the reductive amination reaction, the sent catalyst is filtered and the filtrate concentrated to dryness. The amino compounds produced by the above procedures are isolated by taking advantage of their basic nature which permits convenient separation from non-basic byproducts and reactants. In general, an aqueous solution of the product is extracted over a range of gradually increasing pH so that non-basic materials are removed at the lower pH's and the product at a pH of about 9. The extracting solvents, e.g., ethyl acetate, diethyl ether, are back-washed with brine and water, dried and evaporated to give the product. A further favored procedure comprises reaction of the appropriate compound of formula I or II wherein R2 or R3 is #-hydroxy substituted alkyl with equimolar quantities of phthalimide, triphenylphosphine and diethylazodicarboxylate. Compounds of this invention of Formula I wherein R is amino are prepared in like manner from formula I or II compounds. If either of R2 or R3 is oxo-substituted alkyl and introduction of an amino group at the 1-position of the cycloalkyl moiety is desired, said oxo group must be protected as by ketal formation. When amino groups are to be introduced simultaneously into the l-position of the cycloalkyl moiety and R2 (or R3), the above-described processes are used but, of course, doubling the molar proportions of reactants per mole of oxo-containing reactant. Mono- and dialkylamino substituted alkyl derivatives (R2, R3) of formulae I and II compounds are prepared by reductive alkylation of the corres < pding aminoalkyl derivatives with the appropriate aldehyde or ketone in the presence of a reducing agent such. as molecular hydrogen and a catalyst (Pd or Raney nickel) or nascent hydrogen from a metal-acid combination. When mono- or dimethylamino derivatives are desired, the Leuckart reaction, in which formic acid or one of its derivatives, such as ammonia formate, serve as reducing agent, is used. It has been found that the compound of formula I wherein R is OH; R2 is (CH2)30H, -ZW is -C(CH3)2(CH2)5CH3 and R1 is benzyl (C7H7) can be resolved into diastereomers A and B by reaction with d-mandelic acid and p-toluenesulfonic acid in benzene with azeotropic removal of water. Hydrolysis of the bis-dmandelate esters of diastereomers A and B (e.g., K2CO3 in methanol-water) affords enantiomers A and B. In like manner, reaction of enantiomer B with l-mandelic acid and p-toluenesulfonic acid in benzene with azeotropic removal of water affords dizsterecmer A of the bis-l-mandelate derivative. Hydrolysis as described above affords enantiomer B. Removal of the protecting benzyl groups affords the corresponding enantiomeric alcohols. Similarly, the benzyl ether of the above-mentioned compound (R2 = ...... (CH2)3-O-C7H7) is resolved into its diastereomers and enantiomers. Other compounds of formula I herein are also resolved in like manner. Compounds o formulae I and II wherein R2 and R3 are alkyl substituted with -SR6, -S(O)R6 or -S (0) 2R6 are also active as CNS agents and antiemetics and are used in the same manner as are the formulae I and II compounds described herein. Said compounds wherein the alkyl substituent is -SR6 are prepared from corresponding alcohols via halogenation (SOCl2) and reaction of the thus produced chloride with HSR6 in the presence of a base. Oxidation of the -SR6-substituted alkyl group with one or two equivalents of hydrogen peroxide or a peracid, e.g., m-chlor-perbenzoic acid, affords the corresponding sulfoxide or sulfone. Acyl derivatives of formulae I and II compounds wherein R1 is hydroxy and any of R, R2 or R3 is hydroxy, amino, or hydroxyalkyl or aminoalkyl are prepared by acylation with the appropriate alkanoic acid in the presence of a condensing agent such as dicyclohexylcarbodiimide, or by reaction with the appropriate alkanoic acid chloride or anhydride in the presence of a base such as pyridine. The order of activity of the acylatable R, R1, R2 and R3 groups which are or which contain a hydroxy group is primary alcoholic OH, phenolic OH, secondary OH. Esters of compounds of formulae I and II wherein R is hydroxy, OR1 is hydroxy and R2 or R3 contain no acylatable group, are prepared by acylation according to the above-described procedures. Compounds in which only the R group is acylated are obtained by mild hydrolysis of the corresponding diacyl derivative, advantage being taken of the greater ease of hydrolysis of the phenolic acyl group. The analgesic properties of the compounds of this invention are determined by tests using nociceptive stimuli. It is noted that compounds of formulae I and II wherein R1 is benzyl are not pharacologically active for the purposes described herein but are useful as intermediates for said compounds wherein R1 is hydrogen. Tests Using Thermal Nociceptive Stimuli a) Mouse Hot Plate Analgesic Testing -^ The method used is modified after WooEe-and MacDonald, J. Pharmacol. Exp. Ther., 80, -3 307 (1944). A controlled heat stimulus is applied to the feet of mice on a 1/8-inch thick aluminum place A 250 watt reflector infrared heat lamp is pisted under the bottom of the aluminum plate. A thermal regulator, connected to thermistors on the plate surface, programs the heat lamp to maintain a constant temperature of 570 C. Each mouse is dropped into a glass cylinder (6 1/2-inch diameter) resting on the hot plate, and timing is begun when the animal's feet touch the plate. The mouse is observed at 0.5 and 2 hours after treatment with the test compound for the first °flicking" movements of one or both hind feet, or until 10 seconds elapse without such movements. Morphine has an MPE50 = 4-5.6 rag./kg. (s.c.). b) Mouse Tail Flick Analgesic Testing Tail flick testing in mice is modified after D'Amour and Smith, J. Pharmacol. Exp. Ther., 72, 74-79 (1941) using controlled high intensity heat applied to the tail. Each mouse is placed in a snug-fitting metal cylinder, with the tail protruding through one end. This cylinder is arranged so that the tail lies flat over a concealed heat lamp. At the onset of testing, an aluminum flag over the lamp is drawn back, allowing the light beam to pass through the slit and focus onto the end of the tail. A timer is simultaneously activated. The latency of a sudden flick of the tail is ascertained. Untreated mice usually react within 3-4 seconds after exposure to the lamp. The end point for protection is 10 seconds. Each mouse is tested at 0.5 and 2 hours after treatment with morphine and the test compound. Morphine has an MPRso of 3.2-5.6 mg./kg. (s.c.). c) Tail Immersion Procedure The method is a modification of the receptacle procedure developed by Benbasset, et al., Arch. int. Pharmacodyn., 122, 434 (1959). Male albino mice (19-21 g.) of the Charles River CD-1 strain are weighed and marked for identification. Five animals are normally used in each drug treatment group with each animal serving as its own control. For general screening purposes, new test agents are first administered at a dose of 56 mg./kg. intraperitoneally or subcutaneously, delivered in a volume of 10 ml./5g. Preceding drug treatment and at 0.5 and 2 hours post drug, each animal is placed in the cylinder. Each cylinder is provided with holes to allow for adequate ventilation and is closed by a round nylon plug through which the animals tail protrudes. The cylinder is held in an upright position and the tail is completely immersed in the constant temperature waterbath (56 C.). The endpoint for each trial is an energetic jerk or twitch of the tail coupled with a motor response. In some cases, the endpoint may be less vigorous post drug. To prevent undue tissue damage, the trial is terminated and the tail removed from the waterbath within 10 seconds. The response latency is recorded in seconds to the nearest 0.5 second. A vehicle control and a standard of known potency are tested concurrently with screening candidates. If the activity of a test agent has not returned to baseline values at the 2four testing point, response latencies are determined at 4 and 6 hours. A final measurement is made at 24 hours if activity is still observed at the end of the test day. Test Using Chemical Nociceptive Stimuli Suppression of Phenylbenzoquinone Irritant-Induced Writhing. Groups of 5 Carworth Farms CF-1 mice are pretreated subcutaneously or orally with saline, morphine, codeine or the test compound. Twenty minutes (if treated subcutaneously) or fifty minutes (if treated orally) later, each group is treated with intraperitoneal injection of phenylbenzoquinone, an irritant known to produce abdominal contractions. The mice are observed for 5 minutes for the presence or absence of writhing starting 5 minutes after the injection of the irritant. MPE50 '5 of the drug pretreatments in blocking writhing are ascertained. Tests Using Pressure Nociceptive Stimuli Effect on the Baffner Tail Pinch Procedure A modification of the procedure of Haffner, Exerimentelle Prufung Schmerzstillender. Deutch Med. Wschr., 55, 731-732 (1929) is used to ascertain the effects of the test compound on aggressive attacking responses elicited by a stimulus pinching the tail. Male albino rats (50-60 g.) of the Charles River (Sprague-Dawley) CD strain are used. Prior to drug treatment, and again at 0.5, 1, 2 and 3 hours after treatment, a Johns Hopkins 2.5-inch "bulldog" clamp is clamped onto the root of the rat's tail. The endpoint at each trial is clear attacking and biting behavior directed toward the offending stimulus, with the latency for attack recorded in seconds. The clamp is removed in 30 seconds if attacking has not yet occurred, and the latency of response is recorded as 30 seconds. Morphine is active at 17.8 mg./kg. (i.p.). Tests Using Electrical Nociceptive Stimuli The "Flir.ch-Jum" Test A modification of the flinch-jump procedure of Tenen, Psychopharmacologia, 12, 278-285 (1968) is used for determining pain thresholds. Male albino rats (175-200 g.) of the Charles River (Sprague-Dawley) CD strain are used. Prior to receiving the drug, the feet of each rat are dipped into a 20% glycerol/saline solution. The animals are then placed in a chamber and presented with a series of l-second shocks to the feet which are delivered in increasing intensity at 30-second intervals. These intensities are 0.26, 0.39, 0.52, 0.78, 1.05, 1.31, 1.58, 1.86, 2.13, 2.42, 2.72 and 3.04 mA. Each animal's behavior is rated for the presence of (a) flinch, (b) squeak and (c) jump or rapid forward movement at shock onset. Single upward series of shock intensities are presented to each rat just prior to, and at 0..5, 2: 4 and 24 hours subsequent to drug treatment. Results of the above tests are recorded as percent maximum possible effect (%MPE). The %MPE of each group is statistically compared to the %MPE of the standard and the predrug control values. The %MPE is calculated as follows: 8MPE = test time - cbntrol time cutoff time - control time x 100 The compounds of this invention, when used as analgesics via oral or parenteral administration, are conveniently administered in composition form. Such cocositions include a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practices. For example, they can be administered in the form of tablets, pills, powders or granules containing such excipients as starch, milk sugar, certain types of clay, etc. They can be acninistered in capsules, in admixtures with the same or equivalent excipients. They can also be administered in the form of oral suspensions, solutions, emulsions, syrups and elixirs which may contain flavoring and coloring agents. For oral administration of the therapeutic agents of this invention, tablets or capsules containing from about 0.01 to about 100 mg. are suitable for most applications. By means of the above procedures, the analgesic activity of several compounds of this invention s determined. The compounds have the formula shown below: EMI32.1 Table I MPE50 (mg./kg.) R2 A B S Z-W PBO RTC HP TF FJ CH2OH H OH 1 C(CH3)2C6H13 1.71 1.26 (CH2)2OH H OH 1 C(CH3)2C6H13 2.58 7.85 (CH2)3OH H OH 1 C(CH3)2C6H13 0.29 0.46 1.11 0.55 0.63 (CH2)3OH(a) H OH 1 C(CH3)2C6H13 0.06 0.13 0.66 0.41 (CH2)3OH(b) H OH 1 C(CH3)2C6H13 14.6 (CH2)4OH H OH 1 C(CH3)2C6H13 0.23 1.15 (CH2)5OH H OH 1 C(CH3)2C6H13 0.55 2.64 (CH2)3OCH3 H OH 1 C(CH3)2C6H13 0.37 ¯1.00 CHO H OH 1 C(CH3)2C6H13 2.59 EMI33.1 Table <SEP> I <SEP> (continued) <SEP> MPE50 <SEP> (mg./kg.) <tb> R2 <SEP> A <SEP> B <SEP> S <SEP> Z-W <SEP> PBQ <SEP> RTC <SEP> HP <SEP> TF <SEP> FJ <tb> CH2CHO <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> 1.21 <tb> CH2COOH <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> > 56 <tb> (CH2)2COOH <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> #56 <tb> (CH2)2COOCH3 <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> 7.53 <SEP> 30.6 <tb> (CH2)2CONH2 <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> ¯56 <tb> CH2NH2 <SEP> H <SEP> OH <SEP> 1C(CH3)2C6H13 <SEP> #56 <tb> (CH2)2NH2 <SEP> HCl <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> > 56 <tb> CH2N(CH3)2 <SEP> HCl <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> ¯56 <tb> (CH2)3N(CH3)2 <SEP> HCl <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> 6.38 <tb> CH2CHOHCH3(c) <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> 1.00 <tb> CH2CHOHCH3(d) <SEP> H <SEP> OH <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> 0.77 <tb> CH2NH2 <SEP> OH <SEP> H <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> ¯56 <tb> CH2N(CH3)2HCl <SEP> OH <SEP> H <SEP> 1 <SEP> > 56 <tb> (CH2)3OH <SEP> H <SEP> H <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> 0.93 <tb> (CH2)3OH <SEP> H <SEP> OH <SEP> 2 <SEP> C(CH3)2C6H13 <SEP> 0.1 <SEP> 0.4 <SEP> 7.8 <SEP> 1.0 <SEP> 1.0 <tb> EMI34.1 Table <SEP> I <SEP> (continued) <SEP> MPE50 <SEP> (mg./kg.) <tb> R2 <SEP> A <SEP> B <SEP> S <SEP> Z-W <SEP> PBQ <SEP> RTC <SEP> HP <SEP> TF <SEP> FJ <tb> (CH2)3OH <SEP> OH <SEP> H <SEP> 2 <SEP> C(CH3)2C6H13 <SEP> 1.11 <SEP> ¯32 <SEP> 3.56 <tb> (CH2)3OH(e) <SEP> OH <SEP> H <SEP> 2 <SEP> C(CH3)2C6H13 <SEP> 0.06 <SEP> 0.1 <SEP> 0.2 <SEP> 0.2 <SEP> 0.3 <tb> (CH2)3OH(f) <SEP> H <SEP> OH <SEP> 2 <SEP> C(CH3)2C6H13 <SEP> ¯10 <tb> (CH2)3OH <SEP> H <SEP> NHAC <SEP> 2 <SEP> C(CH3)2C6H13 <SEP> 0.2 <SEP> 1.0 <tb> (CH2)3OH-o- <SEP> 2 <SEP> C(CH3)2C6H13 <SEP> 1.20 <SEP> ¯56 <tb> (CH2)3OH <SEP> -o- <SEP> 1 <SEP> C(CH3)2C6H13 <SEP> 0.38 <SEP> ¯1.00 <tb> (CH2)3OH <SEP> H <SEP> OH <SEP> 1 <SEP> # <SEP> 0.27 <tb> (CH2)3OH <SEP> OH <SEP> H <SEP> 1 <SEP> # <SEP> 0.54 <tb> (CH2)3OH <SEP> H <SEP> OH <SEP> 1 <SEP> # <SEP> 0.50 <tb> (CH2)3OH <SEP> OH <SEP> H <SEP> 1 <SEP> # <SEP> 2.87 <tb> (CH2)3OH <SEP> H <SEP> OH <SEP> 2 <SEP> # <SEP> 0.99 <tb> a) <SEP> (-) <SEP> enantiomer <tb> b) <SEP> (+) <SEP> enantiomer <tb> c) <SEP> diastereomer <SEP> A <tb> d) <SEP> diastereomer <SEP> B <tb> e) <SEP> (-) <SEP> enantiomer <tb> f) <SEP> (+) <SEP> enantiomer <tb> EMI35.1 Table II EMI35.2 <tb> <SEP> MPE50 <SEP> (mg./kg.) <tb> R3 <SEP> A <SEP> B <SEP> PBQ <SEP> RTC <tb> HOc- <SEP> H <SEP> OH <SEP> 5.6 <tb> HOz <SEP> Illrt <SEP> H <SEP> OH <SEP> 13.9 <SEP> 39.2 <tb> HOIIilu <SEP> OH <SEP> H <SEP> 5.8 <SEP> > 56 <tb> NC <SEP> -- <SEP> H <SEP> OH <SEP> 7.20 <tb> HOCH2 <SEP> H <SEP> OH <SEP> 1.21 <SEP> 3.34 <tb> NC <SEP> c- <SEP> ------- <SEP> 0 <SEP> ------- <SEP> 2.87 <tb> The antiemetic properties of the compounds of formulae I and II are determined in unanesthetized unrestrained cats according to the procedure described in Proc. Soc. Exptl. Biol. and Med., 160, 437-440 (1979). The compounds of the present invention are active antiemetics via oral and parenteral administration and are conveniently administered in composition form. Such compositions include a pharmaceutical carrier selected on the basis of the chosen route or administration and standard pharmaceutical practice. For example, they may be administered in the form of tablets, pills, powders or granules containing such excipients as starch, milk sugar, certain types of clay, etc. They may be administered in capsules, in admixtures with the same or equivalent excipients. They may also be administered in the form of oral suspensions, dispersions, solutions, emulsions, syrups and elixirs which may contain flavoring and coloring agents. For oral administration of the therapeutic agents- of this invention, tablets or capsules containing from about 0.01 to about 100 mg. are suitable for most applications. The physician will determine the dosage which will be most suitable for an individual patient and it will vary with the age, weight and response of the particular patient and the route of administration. Generally, however, the initial analgesic dosage in adults may range from about 0.1 to about 750 mg. per day in single or divided doses. In many instances, it is not necessary to exceed 100 mg. daily. The favored oral dosage range is from about 1.0 to about 300 mg./day; the preferred dose is from about 1.0 to about 50 mg./day. The favored parenteral dose is from about 0.1 to about 100 mg./day; the preferred range from about 0.1 to about 20 mg./day. This invention also provides pharmaceutical compositions, including -unit dosage forms, valuable for the use of the herein described compounds as analgesics and other utilities disclosed herein. The dosage form can be given in single or multiple doses, as previously noted, to achieve the daily dosage effective for a particular utility. The compounds (drugs) described herein can be formulated for administration in solid or liquid form for oral or parenteral administration. Capsules containing drugs of this invention are prepared by mixing one part by weight of drug with nine parts of excipient such as starch or milk sugar and then loading the mixture into telescoping gelatin capsules such that each capsule contains 100 parts of the mixture. Tablets containing said compounds are prepared by compounding suitable mixtures of drug and standard ingredients used in preparing tablets, such as starch, binders and lubricants, such that each tablet contains from 0.10 to 100 mg. of drug per tablet. EXAMPLE 1 Trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl) phenyl]-4-(2-propanyl)cyclohexanone A solution of 73.0 g. (0.188 mole) of l-bromo-2benzyloxy-4-(1,1-dimethylheptyl)benzene (BrZ') in 350 ml. of tetrahydrofuran was slowly added to 9.0 g. (0.375 mole) of 70-80 mesh magnesium metal. After a 5 minute initiation period the rate of addition was adjusted so as to just maintain reflux. The reaction was stirred 1.5 hours longer following completion of addition while cooling to 250 C. The reaction was cooled to -20 C. and 1.78 g. (9.33 mmoles) of cuprous iodide added. The resultant mixture was stirred 5 minutes and then a solution of 25.5 g. (0,188 mole) of 4-(2-procenyl)-2-cyclohexen-1-one (enone) in 30 ml. of tetrahydrofuran added dropwise while the reaction temperature was maintained at about -18 C. Additional 1.78 g. (9.38 mmoles) portions of cuprous iodide were added following addition of 1/3 and 2/3 of the enone reactant. The reaction was stirred 5 minutes longer at -20 C. and then added to 1000 ml. of ice cold saturated ammonium chloride. The quenched mixture was extracted with 1000 ml. of ether and the organic extract washed twice with 500 ml. of saturated ammonium chloride, once with 500 ml. of saturated sodium chloride, dried over magnesium sulfate and evaporated (aspirator) to an oil. The crude oil was purified via column chromatography on 1 kg. of silica gel eluted with 20% etherhexane to yield 58.3 g. (70%) of the title compound as an oil. IR (CHC13) 1712, 1645, 1613 and 1575 cml MS (m/e) 446 (M+), 360, 354 and 91. PMR $TMS CDCI3 0.82 (m, terminal methyl), 1.23 (s, gem dimethyl), 4.7-5.1 (m, vinyl H), 5.02 (s, benzylic methine), 5.3-6.1 (m, vinyl H), 6.79 (d, J=2Hz, ArH), 6.82 (dd, J=8 and 2Hz, ArH) and 7.0 (d, J=8Hz, ArH). - like manner the following compounds were pre@@@d from the appropriate 4-(R2-substituted-2cycloaken-l-one (enone) in place of the enone used above rnd proportionate amounts of magnesium metal, cup @@@ iodide and l-bromo-2-benzyloxy-4-(l,l-dimethyl- heprylbenzene EMI38.1 EMI39.1 Gm. <SEP> Reactants <SEP> Product <tb> Ir(CHCl3) <SEP> TMS <tb> R2 <SEP> s <SEP> Enone <SEP> BrR <SEP> Yield <SEP> Cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> # <tb> (CH2)2CH=CH <SEP> 1 <SEP> 5.98 <SEP> 15.4 <SEP> 11.0 <SEP> g. <SEP> 1715, <SEP> 460 <SEP> (M+) <SEP> 0.81 <SEP> (m, <SEP> terminal <SEP> methyl, <SEP> 1.21 <SEP> (s, <tb> (39.9 <SEP> (39.6 <SEP> (60%) <SEP> 1650, <SEP> 375, <SEP> 369 <SEP> gem <SEP> dimethyl), <SEP> 4.5-5.0 <SEP> and <SEP> 5.1-5.6 <tb> mM) <SEP> mM) <SEP> an <SEP> oil <SEP> 1618, <SEP> (m, <SEP> vinyl <SEP> H), <SEP> 5.01 <SEP> (s, <SEP> benzylic <tb> 1577, <SEP> methylene), <SEP> 6,79 <SEP> (d, <SEP> J=2Hz, <SEP> ArH), <tb> 6,79 <SEP> (dd, <SEP> J=8 <SEP> and <SEP> 2Hz, <SEP> ArH), <SEP> 7.00 <tb> (d, <SEP> J=8Hz, <SEP> ArH) <SEP> and <SEP> 7.30 <SEP> (s, <SEP> PhH) <tb> CH2CH=CH2 <SEP> 2 <SEP> 12.7 <SEP> 50.4 <SEP> 25.3 <SEP> g. <SEP> 1702, <SEP> 454 <SEP> (M+) <SEP> 0.80 <SEP> (m, <SEP> terminal <SEP> methyl), <SEP> 1.21 <tb> 84.4 <SEP> (126 <SEP> (66%) <SEP> 1650, <SEP> 91 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 4.6-5.0 <SEP> and <SEP> 5.1mM) <SEP> mM) <SEP> an <SEP> oil <SEP> 1618, <SEP> 5.9 <SEP> (m, <SEP> vinyl <SEP> H), <SEP> 5.00 <SEP> (s, <SEP> benzylic <tb> 1580 <SEP> methylene), <SEP> 6.85 <SEP> (m, <SEP> Arll), <SEP> 7.00 <SEP> (d, <tb> J=8Hz, <SEP> ArH) <SEP> and <SEP> 7.36 <SEP> (bs, <SEP> PhH) <tb> CH(OCH3)2 <SEP> 1 <SEP> 10.0 <SEP> 22,9 <SEP> 14.1 <SEP> g. <SEP> 1721, <SEP> 480 <SEP> (M+) <SEP> 0.85 <SEP> (m,terminal <SEP> methyl), <SEP> 1.30 <SEP> (s, <tb> (58,8 <SEP> (58,8 <SEP> (50%) <SEP> 1626, <SEP> 413, <SEP> 353, <SEP> gem <SEP> dimethyl), <SEP> 3,25 <SEP> and <SEP> 3,26 <SEP> (s, <tb> mM) <SEP> mM) <SEP> an <SEP> oil <SEP> 1584 <SEP> 329, <SEP> 323, <SEP> methoxys), <SEP> 3,38 <SEP> (m, <SEP> methine), <SEP> 3.96 <tb> 319, <SEP> 91 <SEP> (d, <SEP> J=2Hz, <SEP> ketal <SEP> methine), <SEP> 5.10 <SEP> (s, <tb> benzylic <SEP> methylene), <SEP> 6.9 <SEP> (m, <SEP> ArH), <tb> 7.10 <SEP> (d, <SEP> J=8Hz, <SEP> ArH) <SEP> and <SEP> 7.42 <SEP> (bs, <tb> phH) <tb> EMI40.1 Gm. <SEP> Reactants <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> TMS <tb> R2 <SEP> s <SEP> Enone <SEP> BrRo <SEP> Yield <SEP> Cm-Ú <SEP> MS(m/e) <SEP> PMR <SEP> # <tb> CDCl3 <tb> (CH2)3-O- <SEP> 1 <SEP> 11.0 <SEP> 35.0 <SEP> 12.3 <SEP> g. <SEP> 1709, <SEP> 554.3730 <SEP> 0.83 <SEP> (m, <SEP> terminal <SEP> methyl), <SEP> 1.26 <SEP> (s, <tb> CH2C6H5 <SEP> (45.5 <SEP> (90.0 <SEP> (50%) <SEP> 1600, <SEP> (M+) <SEP> gem <SEP> dimethyl), <SEP> 1.8-2.8 <SEP> and <SEP> 2.8-3.5 <tb> mM) <SEP> mM) <SEP> an <SEP> oil <SEP> 1568 <SEP> 463, <SEP> 445, <SEP> (m), <SEP> 4.40 <SEP> and <SEP> 5.08 <SEP> (s, <SEP> benzylic <tb> 373, <SEP> 355, <SEP> methylenes), <SEP> 6.9 <SEP> (m, <SEP> ArH), <SEP> 7.07 <SEP> (d, <tb> 337, <SEP> 319, <SEP> J=8Hz, <SEP> ArH), <SEP> 7.30 <SEP> and <SEP> 7.38 <SEP> (s, <SEP> PhH) <tb> 91 <tb> (a) <tb> (a) HRMS (m/e) : M+ calc'd for C38H50O3 : 554.3747 EXAMPLE 2 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] trans-4-(2-propenyl)cyclohexanol and the trans, cis isomer To a 0 C. solution of 14.3 g. (32.1 moles) of trans-3-t2-benzyloxy-4-(1,1-dimethylheptyl)phenyll-4- (2-propenyl)cyclohexanone in 50 ml. of methanol was added 1.22 g. (32.1 mmoles) of sodium borohydride. The reaction was stirred 30 minutes at 0 C. and then added to 500 ml. saturated sodium chloride and 300 ml. ether. The organic extract was washed twice with 500 ml. saturated sodium chloride, dried over magnesium sulfate and evaporated (aspirator) to an oil. The crude oil was purified via column chromatography on 200 g. of silica gel eiuted with 2:1 pentane:ether to yield in order of elution 1.9 g. (13%) of the trans, cis-isomer of the title compound as an oil, 2.7 g. (19%) of a mixture of isomers and 7.3 g. (51%) of the title compound as an oil. Cis-3, trans-4 isomer: IR (CHC13) 3571, 3401, 1639, 1610 and 1572 cm 1. MS (m/e) 448 (M), 406, 363 and 91. PMR sTMS 0.82 (m, terminal methyl), 1.22 (s, gem CDCI3 dimethyl), 2.90 (m, benzylic methine), 3.73 (m, carbinol methine), 4.6-5.1 (m, vinyl H), 5.02 (s, benzylic methylene), 5.3-6.3 (m, vinyl H), 6.75 (d, J=2Hz, ArH), 6.75 (dd, J=8 and 2Hz, ArH), 6.99 (d, J=8Hz, ArH) and 7.25 (bs, Ph). Trans-3, cis-4 isomer: IR (CHCl3) 3559, 3401, 1639, 1608 and 1567 cm 1. MS (m/e) 448 (M+), 433, 430, 363, 406 and 91. PMR #TMSCDCI3 0.82 (m, terminal methyl), 1.25 (s, gem dimethyl), 3.30 (m, benzylic methine), 4.12 (m, carbinol methine), 4.6-5.0 (m, vinyl H), 5.06 (s, benzylic methylene), 5.2-6.1 (m, vinyl H), 6.82 (d, J=2Hz, ArH), 6.82 (dd, J=8 and 2Hz, ArH), 7.07 (d, J=3Hz, ArH) and 7.38 (bs, Ph). Following the above procedure, the compounds tabulated below were prepared from appropriate 3-[2-benzyloxy-4- (1,1-dimethylheptyl)phenyl]-4-(2-R2-substituted)cycloalkanones and stoichiometric amounts of sodium borohydride, i.e., one gram atom/oxo group present: EMI42.1 In the table, R0 represents the 3-(2-benzyloxy-4 (1,1-dimethylheptyl)phenyl]moiety. EMI43.1 # <SEP> Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> R2 <SEP> R <SEP> Gms. <SEP> R <SEP> R2 <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> # <tb> CDCl3 <tb> 1 <SEP> (CH2)2CH=CH2 <SEP> trans <SEP> 5.5 <SEP> trans <SEP> cis <SEP> 0.9 <SEP> g. <SEP> 3413, <SEP> 462(M+), <SEP> 0.8 <SEP> (m, <SEP> terminal <tb> (12mM) <SEP> (16%) <SEP> 1658, <SEP> 377, <SEP> methyl), <SEP> 1.20 <SEP> (s, <tb> an <SEP> oil <SEP> 1626, <SEP> 353, <SEP> 91 <SEP> gem <SEP> dimethyl), <tb> 1585 <SEP> 3.2 <SEP> (m, <SEP> benzylic <tb> methine), <SEP> 4.09 <tb> 5,0 <SEP> and <SEP> 5.1-6.0 <tb> (m, <SEP> terminal <tb> olefin), <SEP> 5.05 <SEP> (s, <tb> benzylic <SEP> methylene), <SEP> 6.82 <tb> (dd), <SEP> J=8 <SEP> 4.65.0 <SEP> and <SEP> 5.1-6.0 <tb> (m, <SEP> terminal <tb> olefin), <SEP> 5.05 <SEP> (s, <tb> benzylic <SEP> methylene), <SEP> 6.82 <SEP> (d, <tb> J=2, <SEP> ArH), <SEP> 6.82 <tb> (dd, <SEP> J=8 <SEP> and <SEP> 2Hz, <tb> ArH), <SEP> 7.07 <SEP> (d, <tb> J=8Hz, <SEP> ArH) <SEP> and <tb> 7.38 <SEP> (m, <SEP> PhH). <tb> cis <SEP> trans <SEP> 2.9 <SEP> g. <SEP> 3367, <SEP> 462(M+), <SEP> 0.81 <SEP> (m, <SEP> terminal <tb> (52%) <SEP> 1656, <SEP> 377, <SEP> methyl), <SEP> 1.21 <SEP> (s, <tb> an <SEP> oil <SEP> 1623, <SEP> 91 <SEP> gem <SEP> dimethyl), <tb> 1582 <SEP> 2.85 <SEP> (m, <SEP> benzylic <tb> methine), <SEP> 3.60 <SEP> (m, <tb> carbinol <SEP> methine), <tb> 4,5-5.0 <SEP> and <SEP> 5.16.0 <SEP> (m, <SEP> terminal <tb> olefin), <SEP> 5.00 <SEP> (s, <tb> EMI44.1 # <SEP> Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> R2 <SEP> R <SEP> Gms. <SEP> R <SEP> R2 <SEP> Yield <SEP> cm-Ú <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> benzylic <SEP> methylene), <SEP> 6.80 <SEP> (m, <tb> ArH), <SEP> 6.99 <SEP> (d, <SEP> J= <tb> 8Hz, <SEP> ArH) <SEP> and <tb> 7.30 <SEP> (bs, <SEP> PhH). <tb> 1 <SEP> (CH2)4CHO <SEP> trans <SEP> 0.400 <SEP> cis <SEP> trans <SEP> 0.335 <SEP> g. <SEP> 0.82 <SEP> (m, <SEP> terminal <tb> (0.816 <SEP> (CH2)5OH <SEP> (84%) <SEP> methyl), <SEP> 1.22 <SEP> (s, <tb> mM) <SEP> an <SEP> oil <SEP> gem <SEP> dimethyl), <tb> 2.85 <SEP> (m, <SEP> benzylic <tb> methine), <SEP> 3.50 <tb> (t, <SEP> J=7Hz, <SEP> alcohol <tb> methylene), <SEP> 3.55 <tb> (m, <SEP> carbinol <tb> methine), <SEP> 5.05 <SEP> (s, <tb> benzylic <SEP> methine), <tb> 6.85 <SEP> (m, <SEP> ArH), <tb> 7.02 <SEP> (d, <SEP> J=8Hz, <tb> ArH) <SEP> and <SEP> 7.32 <SEP> (bs <tb> PhH). <tb> EMI45.1 # <SEP> Reactant <SEP> Product <tb> IR <SEP> (CHCl)3 <SEP> #TMS <tb> s <SEP> R2 <SEP> R <SEP> Gms. <SEP> R <SEP> R2 <SEP> Yield <SEP> cm-Ú <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> 1 <SEP> CH2CH2OH <SEP> trans <SEP> 0.900 <SEP> trans <SEP> cis <SEP> 0.130 <SEP> g. <SEP> 3571, <SEP> 452 <SEP> (M+), <tb> (2.01 <SEP> (14%) <SEP> 3425, <SEP> 432, <SEP> 367, <tb> mM) <SEP> an <SEP> oil <SEP> 1613, <SEP> 359, <SEP> 344, <tb> 1575 <SEP> 343, <SEP> 300, <tb> 259, <SEP> 91 <tb> cis <SEP> trans <SEP> 0.770 <SEP> g. <SEP> 3636, <SEP> 452(M+), <tb> (85%) <SEP> 3472, <SEP> 432, <SEP> 367, <tb> an <SEP> oil <SEP> 1623, <SEP> 359, <SEP> 349, <tb> 1580 <SEP> 343, <SEP> 259, <tb> 91 <tb> 1 <SEP> CH2-CH-CH3 <SEP> trans <SEP> 0.621 <SEP> trans <SEP> cis <SEP> 0.096 <SEP> g. <SEP> 466(M+), <tb> OH <SEP> (1.33 <SEP> (15%) <SEP> 451, <SEP> 448, <tb> mM) <SEP> an <SEP> oil <SEP> 381, <SEP> 358, <tb> Diastereomer <SEP> A <tb> cis <SEP> trans <SEP> 0.425 <SEP> g. <SEP> 3623, <SEP> 466(M+), <tb> (69%) <SEP> 1618, <SEP> 451, <SEP> 448, <tb> an <SEP> oil <SEP> 1580 <SEP> 381, <SEP> 358, <tb> 274, <SEP> 214, <tb> 91 <tb> EMI46.1 # <SEP> Reactant <SEP> Product <SEP> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> R2 <SEP> R <SEP> Gms. <SEP> R <SEP> R2 <SEP> Yield <SEP> cm-Ú <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> trans <SEP> 0.895 <SEP> trans <SEP> cis <SEP> 0.079 <SEP> g. <SEP> 466(M+), <tb> (1.92 <SEP> (9%) <SEP> 451, <SEP> 448, <tb> mM) <SEP> an <SEP> oil <SEP> 381, <SEP> 358, <tb> 273, <SEP> 213, <tb> 91 <tb> Diastereomer <SEP> B <SEP> cis <SEP> trans <SEP> 0.555 <SEP> g. <SEP> 3636, <SEP> 466(M+), <tb> (62%) <SEP> 3484, <SEP> 451, <SEP> 448, <tb> an <SEP> oil <SEP> 1626, <SEP> 381, <SEP> 91 <tb> 1582 <tb> 1 <SEP> CH(OCH3)2 <SEP> trans <SEP> 35.6 <SEP> cis <SEP> trans <SEP> 14.4 <SEP> g. <SEP> 3521, <SEP> 482(M+), <SEP> 0.86 <SEP> (m, <SEP> terminal <tb> (73.7 <SEP> (40%) <SEP> 3389, <SEP> 396, <SEP> 359, <SEP> methyl), <SEP> 1.28 <SEP> (s, <tb> mM) <SEP> an <SEP> oil <SEP> 1600, <SEP> 341, <SEP> 327, <SEP> gem <SEP> dimethyl), <tb> 1562 <SEP> 311, <SEP> 91 <SEP> 2.86 <SEP> and <SEP> 2.90 <SEP> (s, <tb> methoxys), <SEP> 3.75 <tb> (m, <SEP> carbinol <SEP> methine), <SEP> 3.65 <SEP> (d, <SEP> J= <tb> 2Hz, <SEP> ketal <SEP> methine), <SEP> 5.10. <SEP> (s, <tb> benzylic <SEP> methylene), <SEP> 6.85 <SEP> (m, <tb> ArH), <SEP> 7.09 <SEP> (d, <SEP> J= <tb> 8Hz, <SEP> ArH) <SEP> and <SEP> 7.4 <tb> (bs, <SEP> PhH). <tb> plus <SEP> mixture <SEP> of <SEP> cis-trans <SEP> and <SEP> trans-cis <SEP> isomers <SEP> 6.3 <SEP> #. <SEP> (18%)--- EMI47.1 # <SEP> Reactant <SEP> Product <SEP> IR <SEP> (CHCl3) <tb> #TMS <tb> s <SEP> R2 <SEP> R <SEP> Gms. <SEP> R <SEP> R2 <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> # <tb> CDCl3 <tb> 1 <SEP> (CH2)3-O- <SEP> trans <SEP> 12.3 <SEP> trans <SEP> cis <SEP> 1.1 <SEP> g. <SEP> 556.3955 <SEP> 0.82 <SEP> (m, <SEP> terminal <tb> CH2C6H5 <SEP> (50.4 <SEP> (9%) <SEP> (M+), <SEP> methyl), <SEP> 1.26 <SEP> (s, <tb> mM) <SEP> an <SEP> oil <SEP> 448, <SEP> 363, <SEP> gem <SEP> dimethyl), <tb> 358, <SEP> 273, <SEP> 3,50 <SEP> (bt, <SEP> J=7Hz, <tb> 91 <SEP> methylene), <SEP> 4.10 <tb> (a) <SEP> (m, <SEP> carbinol <SEP> methine), <SEP> 4.40 <SEP> and <tb> 5.05 <SEP> (s, <SEP> benzylic <tb> methylenes), <SEP> 6.84 <tb> (m, <SEP> ArH), <SEP> 7.05 <SEP> (d, <tb> J=8Hz, <SEP> ArH), <SEP> 7.28 <tb> (s, <SEP> PhH) <SEP> and <SEP> 7.38 <tb> (m, <SEP> PhH). <tb> cis <SEP> trans <SEP> 10.4 <SEP> g. <SEP> 556.3910 <SEP> 0.82 <SEP> (m, <SEP> terminal <tb> (85%) <SEP> (M+), <SEP> methyl), <SEP> 1,25 <SEP> (s, <tb> an <SEP> oil <SEP> 505, <SEP> 448, <SEP> gem <SEP> dimethyl), <SEP> 2.8 <tb> 357, <SEP> 273, <SEP> (m, <SEP> benzylic <SEP> meth91 <SEP> ine), <SEP> 3.25 <SEP> (bt, <SEP> J= <tb> (a) <SEP> 6Hz, <SEP> methylene), <tb> 3,65 <SEP> (m, <SEP> carbinol <tb> methine), <SEP> 4.38 <SEP> and <tb> 5.07 <SEP> (s, <SEP> benzylic <tb> methylenes), <SEP> 6.82 <tb> EMI48.1 # <SEP> Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> R2 <SEP> R <SEP> Gms. <SEP> R <SEP> R2 <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> (d, <SEP> J=2Hz, <SEP> ArH), <tb> 6.82 <SEP> (dd, <SEP> J=8 <SEP> and <tb> 2Hz, <SEP> ArH), <SEP> 7.02 <tb> (d, <SEP> J=8Hz, <SEP> ArH), <tb> 7.23 <SEP> (s, <SEP> PhH) <SEP> and <tb> 7.35 <SEP> (bs, <SEP> PhH). <tb> (a) HRMS (m/e): M+ calc'd. for C38H52O3:556.3903 EXAMPLE 3 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-hydroxymethylcyclohexanol Using the procedure of Example 2, 1.0 g. (2.29 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl)trans-4-oxomethylcyclohexanol is reduced to give a quantitative yield of the title compound as an oil. IR (CHC13) 3400, 1605 and 1562 cm 1. MS (m/e) 438 (M+), 420, 353, 330, 312, 299 and 91. TMS PMR # CDCI3 0.82 (m, terminal methyl), 1.23 (s. gem dimethyl), 3.25 (m, hydroxymethylene), 3.65 (m, carbinol methine), 5.08 (s, benzylic methylene), 6.90 (n, ArH), 7.12 (d, J=8Hz, ArH) and 7.39 (s, Ph). EXAMPLE 4 Trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl]- 4-(2-hydroxyethyl)cyclohexanone ethylene ketal Using the procedure of Example 2, 1.00 g. (2.03 mmole) of trans-3-(2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4 (2-oxoethyl)cyclohexanone ethylene ketal is reduced to give a quantitative yield of the title compound as an oil. PMR TMS 0.82 (m, terminal methyl), 1.11 (s, gem CDCl3 dimethyl), 3.50 (bt, J=6Hz, alcohol methylene), 3.91 (s, ethylene), 5.02 (s, benzylic methylene), 6.8-7.1 (m, ArH) and 7.33 (m, PhH). EXAMPLE 5 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol To a mechanically stirred, 0 C. solution of 2.0 g. (4.46 mmoles) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)- phenyll-trans-4-(2-propenyl)cyclohexanol in 20 ml. of tetrahydrofuran was added 9 ml. (8.92 mmoles) of boran tetrahydrofuran complex (1M in tetrahydrofuran). The reaction was allowed to warm to 250 C. and was then stirred for 30 minutes at 250 C. The reaction was cooled to 0 C. and oxidized by the addition of 1 ml. water, 2.66 ml. (5.34 mmoles) of 2N sodium hydroxide and 0.9-2 ml. (10.7 mmoles) of 30% hydrogen peroxide The reaction was allowed to warm to 250 C., stirred for 35 minutes, and added to 200 ml. saturated sodium chloride and 200 ml. ether. The ether extract was washed twice with 100 ml. of saturated sodium chloride, dried over nagnesiurn sulfate and evaporated (aspirator) to an oil. The crude oil was purified via column chromatography on 40 g. of silica gel, eluted with ether to yield 2.0 g. (96%) of the title compound as an oil. IR (CHCI3) 3623, 3425, 1623 and 1586 cml MS (m/e) 466 (M+), 448, 381, 363, 358, 357 and 91. PMR TMS 0.82 (m, terminal methyl), 1.24 (s, gem CDCl3 dimethyl), 2.90 (m, benzylic methine), 3.2-3.9 (m, carbinol methine and methylene), 5.08 (s, benzylic methylene), 6.86 (d, J=2Hz, ArH), 6.86 (dd, J=8 and 2Hz, ArH) and 7.05 (d, J=8Hz, ArH). In like manner the following compounds are prepared from appropriate reactants. EMI51.1 EMI52.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> R2 <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> 1 <SEP> # <SEP> CH2-CH-CH2 <SEP> 16.2 <SEP> CH2CH2CH2OH <SEP> Quanti- <SEP> 0.86 <SEP> (m, <SEP> termi1 <SEP> (33.1 <SEP> tative <SEP> nal <SEP> methyl), <tb> mM) <SEP> an <SEP> oil <SEP> 1.26 <SEP> (s, <SEP> gem <tb> dimethyl), <SEP> 3.08 <tb> (m, <SEP> benzylic <tb> methine), <SEP> 3.47 <tb> (t, <SEP> J=7Hz, <SEP> alcohol <SEP> methylene), <SEP> 3.93 <SEP> (s, <tb> ethylene), <SEP> 5.10 <tb> (s, <SEP> benzylic <tb> methylene), <tb> 6.90 <SEP> (m, <SEP> ArH), <tb> 7.08 <SEP> (d, <SEP> J=8Hz, <tb> ArH) <SEP> and <SEP> 7.42 <tb> 2 <SEP> # <SEP> CH2-CH=CH2 <SEP> 4.70 <SEP> CH2CH2CH2OH <SEP> Qu@nti- <SEP> 3509, <SEP> 522(M+) <SEP> 0.83 <SEP> (m, <SEP> termi- <SEP> (m. <SEP> PhH). <tb> 0.83(9.32 <SEP> tative <SEP> 1613, <SEP> nal <SEP> methyl), <tb> mM) <SEP> @@@@@ <SEP> 1577, <SEP> 1.23 <SEP> (s, <SEP> gem <tb> 15@@, <SEP> dimethyl), <SEP> 2.9 <tb> @@@@ <SEP> 3,7 <SEP> (m, <SEP> alcohol <tb> methylene <SEP> and <tb> benzylic <SEP> methine), <SEP> 3,82 <SEP> (bs, <tb> ethylene), <SEP> 5.06 <tb> (benzylic <SEP> methylene), <SEP> 6,85 <tb> (m, <SEP> ArH), <SEP> 7.02 <tb> EMI53.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> R2 <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> (d, <SEP> J=8Hz, <SEP> Arh) <tb> and <SEP> 7,38 <SEP> (m, <tb> PhH). <tb> 1 <SEP> H <SEP> OH <SEP> (CH2)2CH=CH2 <SEP> 3,3 <SEP> (CH2)3CH2OH <SEP> 2,3 <SEP> g. <SEP> 3448, <SEP> 480(M+), <tb> (7.14 <SEP> (67%) <SEP> 1623, <SEP> 462. <SEP> 395. <tb> mM) <SEP> an <SEP> oil <SEP> 1580 <SEP> 91 <tb> 2 <SEP> H <SEP> OH <SEP> CH2CH=CH2 <SEP> 1.0 <tb> CH2CH2CH2OH <SEP> 1.0 <SEP> g. <SEP> 0.9 <SEP> (m, <SEP> termi (2.16 <SEP> (97%) <SEP> nal <SEP> methyl), <tb> an <SEP> oil <SEP> 1.28 <SEP> (s, <SEP> gem <tb> dimethyl), <SEP> 3.48 <tb> (m, <SEP> alcohol <tb> methylene), <tb> 3,70 <SEP> (m, <SEP> carbinol <SEP> methine), <tb> 5.02 <SEP> (s, <SEP> benzylic <SEP> methylene) <tb> 6,90 <SEP> (m. <SEP> ArH) <tb> and <SEP> 7.38 <SEP> (bs, <tb> PhH). <tb> 2 <SEP> H <SEP> OH <SEP> CH2-CH=CH2 <SEP> 5.0 <SEP> CH2CH2CH2OH <SEP> 4.2 <SEP> g. <SEP> 0.80 <SEP> (m, <SEP> termi (10.8 <SEP> (82%) <SEP> nal <SEP> methyl), <tb> mM) <SEP> an <SEP> oil <SEP> 1.20 <SEP> (s. <SEP> gem <tb> dimethyl), <SEP> 3,36 <tb> (m, <SEP> alcohol <tb> methylene), <tb> EMI54.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> R2 <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> 4.02 <SEP> (m, <SEP> carbinol <SEP> methine), <tb> 5.07 <SEP> (s, <SEP> benz Ylic <SEP> methylene) <tb> 6,85 <SEP> (m, <SEP> ArH), <tb> 7.06 <SEP> (d, <SEP> J=8Hz, <tb> ArH) <SEP> and <SEP> 7,38 <tb> (s <SEP> PhH). <tb> 2 <SEP> H <SEP> OH <SEP> CH2CH=CH2 <SEP> 0.874 <SEP> CH2CH2CH2OH <SEP> 0.778 <SEP> g <SEP> 480.3561 <tb> (Enantiomer <SEP> A) <SEP> (1,89 <SEP> (86%) <SEP> (M+), <tb> mM) <SEP> an <SEP> oil <SEP> 395, <SEP> 377, <tb> 372, <SEP> 371, <tb> 287, <SEP> 233, <tb> 91 <tb> (a) <tb> (b) <tb> 2 <SEP> H <SEP> OH <SEP> CH2CH=CH2 <SEP> 0.829 <SEP> CH2CH2CH2OH <SEP> 0.686 <SEP> g. <SEP> 480.3565 <tb> (Enantiomer <SEP> B) <SEP> (1,79 <SEP> (80%) <SEP> (M+), <tb> mM) <SEP> an <SEP> oil <SEP> 395, <SEP> 377, <tb> 372, <SEP> 371, <tb> 287, <SEP> 233, <tb> 91 <SEP> (a) <tb> EMI55.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> R2 <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <SEP> CDCl3 <tb> 1 <SEP> H <SEP> OC7H7 <SEP> CH2-CH=CH2 <SEP> CH2CH2CH2OH <SEP> 2.09 <SEP> g. <SEP> 3571, <SEP> 556.3865 <SEP> 1.22 <SEP> (s, <SEP> gem <tb> (97%) <SEP> 3389, <SEP> (M+), <SEP> dimethyl), <SEP> 2,78 <tb> an <SEP> oil <SEP> 1600, <SEP> 540. <SEP> 471, <SEP> (m, <SEP> benzylic <tb> 1562 <SEP> 455, <SEP> 358, <SEP> methine), <SEP> 3,2357, <SEP> 273, <SEP> 4.0 <SEP> (m). <SEP> 4,61 <tb> 272, <SEP> 257, <SEP> and <SEP> 5,12 <SEP> (s, <tb> 91 <SEP> benzylic <SEP> meth (c) <SEP> ylene), <SEP> 6,9 <SEP> (m, <tb> ArH) <SEP> and <SEP> 7.35 <tb> (m, <SEP> PhH). <tb> (a) High resolution mass spectral (HRMS); M+ calcd. for C32H48O3 = 480.3597 (b) [&alpha;]CH3OH, 25 C. = -20.57 (c) HRMS: M+ calcd. for C38H52O3 = 556.3903 EXAMPLE 6 Cis-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl) trans-4-(3-hydroxypropyl)cyclohexanol A mixture of 2.0 g. (4.29 mmole) of cis-3-[2- benzyloxy-4-(1,l-dimethylheptyl)phenyl]-trans-4-(3- hydroxypropyl)cyclohexanol and 300 mg. of 5% Pd/C/508 water in 10 ml. of ethanol was stirred under I atmosphere of hydrogen gas for 45 minutes at room temperature. The reaction was filtered through diatomaceous earth and the filtrate evaporated under reduced pressure to a solid. Recrystallization of the crude solid product from diisopropyl ether gave 1.41 g. (94%) of the title compound m.p.: 132-3 C. (diisopropyl ether). IR (KBr) 3448, 3226, 1626 and 1592 cm-1. MS (m/e) 376 (M+), 358, 304, 291 and 273. PMR (CDC13, D20, D6-DMSO) 6 0.83 (m, terminal methyl), 1.23 (s, gem dimethyl), 3.39 (t, J=6Hz, carbinol methylene), 3.64 (m, carbinol methine), 6.85 (m, ArH) and 6.91 (d, 3=8Hz, ArH) Analysis: Calc'd. for C24H4003: C, 76.55; H, 10.71. Found: C, 76.55; H, 10.44. Similarly, the following compounds are prepared from appropriate benzyl ether reactants: EMI56.1 (The value of R2 is the same in reactant and product). EMI57.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 1 <SEP> # <SEP> CH2CH2CH2OH <SEP> 16.8 <SEP> 11.0 <SEP> g. <SEP> 3509, <SEP> 418(M+), <SEP> 0.82 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (33.1 <SEP> (80%) <SEP> 3279, <SEP> 356, <SEP> 333, <SEP> 1.27 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 2.87 <tb> mM) <SEP> an <SEP> oil <SEP> 1613, <SEP> 332, <SEP> 317, <SEP> (m, <SEP> benzylic <SEP> methine), <SEP> 3,50 <tb> 1567 <SEP> 291, <SEP> 271 <SEP> (t, <SEP> J=6Hz, <SEP> alcohol <SEP> methylene), <SEP> 4.00 <SEP> (s, <SEP> ethylene), <tb> 6,8 <SEP> (m, <SEP> ArH) <SEP> and <SEP> 7.02 <SEP> (d, <tb> J=8Hz, <SEP> ArH). <tb> 1 <SEP> H <SEP> OH <SEP> CH2OH <SEP> 0.890 <SEP> 0.370 <SEP> g. <SEP> 3333, <SEP> 348(M+), <SEP> 0.80 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (2.03 <SEP> (52%) <SEP> 3195, <SEP> 330, <SEP> 312, <SEP> 1.21 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 3,35 <tb> mM) <SEP> mp: <SEP> 137- <SEP> 1612, <SEP> 263, <SEP> 245 <SEP> (m, <SEP> hydroxy <SEP> methylene), <SEP> 3.82 <tb> 138 C. <SEP> 1577 <SEP> (m, <SEP> carbinol <SEP> methine). <SEP> 6.83 <tb> (ether/ <SEP> (KBr <SEP> pellet) <SEP> (m, <SEP> ArH) <SEP> and <SEP> 7.08 <SEP> (d, <SEP> J=8Hz, <tb> pentan(ether/ <SEP> (KBr <SEP> pellet) <SEP> ArH). <SEP> (CDCl3 <SEP> + <SEP> D6-DMSO) <tb> 1 <SEP> H <SEP> OH <SEP> CH2CH2OH <SEP> 0.750 <SEP> 0.487 <SEP> g. <SEP> 3636, <SEP> 362(M+), <SEP> 0.85 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (1.66 <SEP> (81%) <SEP> 3356, <SEP> 344, <SEP> 300, <SEP> 1.28 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 2.80 <tb> mM) <SEP> mp: <SEP> 50- <SEP> 1631, <SEP> 290, <SEP> 277, <SEP> (m, <SEP> benzylic <SEP> methine), <SEP> 3,60 <tb> 55 <SEP> C. <SEP> 1587, <SEP> 259 <SEP> (t, <SEP> J=6Hz, <SEP> alcohol <SEP> methyl (semisolid <SEP> 1577 <SEP> ene), <SEP> 3,8 <SEP> (m, <SEP> carbinol <SEP> methfrom <SEP> pentane) <SEP> ine), <SEP> 6,80 <SEP> (m, <SEP> ArH) <SEP> and <SEP> 7.08 <tb> (d, <SEP> J=8Hz, <SEP> ArH). <tb> EMI58.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 1 <SEP> H <SEP> OH <SEP> (CH2)3CH2OH <SEP> 2.3 <SEP> 1.4 <SEP> g. <SEP> 3390, <SEP> 0.8 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (4,79 <SEP> (75%) <SEP> 3247, <SEP> 1.23 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 2,80 <tb> mM) <SEP> mp: <SEP> 125- <SEP> 1634, <SEP> (m, <SEP> benzylic <SEP> methine), <SEP> 3,2128 <SEP> C. <SEP> 1597 <SEP> 4.0 <SEP> (m, <SEP> alcohol <SEP> methylene <tb> (petroleum <SEP> (KBr <SEP> pellet) <SEP> and <SEP> methine), <SEP> 6,70 <SEP> (m, <SEP> ArH) <tb> ether) <SEP> and <SEP> 6,92 <SEP> (d, <SEP> J=8Hz, <SEP> ArH). <tb> 1 <SEP> H <SEP> OH <SEP> (CH2)4CH2OH <SEP> 0.335 <SEP> 0.164 <SEP> g. <tb> (0.679 <SEP> (60%) <SEP> 404(M+) <SEP> 0.83 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> mM) <SEP> mp: <SEP> 133- <SEP> 3.50 <SEP> (t, <SEP> J=6Hz, <SEP> alcohol <tb> 135 <SEP> C. <SEP> 404(M+) <SEP> methylene), <SEP> 3,65 <SEP> (m, <SEP> car (pentane) <SEP> binol <SEP> methine), <SEP> 6,85 <SEP> (m. <tb> ArH) <SEP> and <SEP> 7.08 <SEP> (d, <SEP> J=8Hz, <tb> ArH). <SEP> (CDCl3 <SEP> + <SEP> D6-DMSO) <tb> 1 <SEP> H <SEP> OH <SEP> CH2CHCH3 <SEP> 0.400 <SEP> 0.290 <SEP> g. <SEP> 3571, <SEP> 376.2946 <tb> OH <SEP> (0.858 <SEP> (88%) <SEP> 3333, <SEP> (M+) <tb> Diastereomer <SEP> A <SEP> mM) <SEP> an <SEP> oil <SEP> 1613, <SEP> (a) <tb> 1577 <tb> EMI59.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 1 <SEP> H <SEP> OH <SEP> CH2CHCH3 <SEP> 0.552 <SEP> 0.291 <SEP> g. <SEP> 3534, <SEP> 376.2987 <tb> OH <SEP> (1.12 <SEP> (69%) <SEP> 3268,(M+) <tb> Diastereomer <SEP> B <SEP> mM) <SEP> mp: <SEP> 139- <SEP> 1613, <SEP> (a) <tb> 140 <SEP> C. <SEP> 1563 <tb> (methylene <tb> chloride <SEP> petroleum <tb> ether) <tb> 1 <SEP> H <SEP> OH <SEP> CH2CHO <SEP> 0.432 <SEP> Quanti- <SEP> 3571, <SEP> 360(M+), <SEP> 0.82 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (0.960 <SEP> tative <SEP> 3333, <SEP> 342, <SEP> 332, <SEP> 1.22 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 2,72 <tb> mM) <SEP> an <SEP> oil <SEP> 1724, <SEP> 316, <SEP> 314, <SEP> (m, <SEP> benzylic <SEP> methine), <SEP> 3,70 <tb> 1623, <SEP> 298, <SEP> 275, <SEP> (m, <SEP> carbinol <SEP> methine), <SEP> 5,60 <tb> 1582 <SEP> 273, <SEP> 257, <SEP> (bs, <SEP> OH), <SEP> 6.65 <SEP> (d, <SEP> J=2Hz, <tb> 247, <SEP> 239, <SEP> ArH), <SEP> 6,80 <SEP> (dd, <SEP> J=8 <SEP> and <SEP> 2Hz <tb> 231, <SEP> 213 <SEP> ArH), <SEP> 7.02 <SEP> (d, <SEP> J=8Hz, <SEP> ArH) <tb> and <SEP> 9,50 <SEP> (t, <SEP> J=2Hz, <SEP> CHO). <tb> 1 <SEP> H <SEP> OH <SEP> CH2-C-CH2OH <SEP> 0.400 <SEP> 0.313 <SEP> g. <SEP> 3623, <SEP> 390 <SEP> (M+), <SEP> 0.87 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (0.833 <SEP> (97%) <SEP> 3378, <SEP> 372, <SEP> 359, <SEP> 1,25 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 2,75 <tb> mM) <SEP> a <SEP> foam <SEP> 1724, <SEP> 316, <SEP> 305, <SEP> (m, <SEP> benzylic <SEP> methine), <SEP> 3,70 <tb> 1626, <SEP> 298, <SEP> 287, <SEP> (m, <SEP> carbinol <SEP> methine), <SEP> 4.00 <tb> 1578, <SEP> 273, <SEP> 231, <SEP> (s, <SEP> hydroxy <SEP> methylene), <SEP> 6,80 <tb> 213 <SEP> (m, <SEP> ArH) <SEP> and <SEP> 7.08 <SEP> (d, <SEP> J=8Hz, <tb> ArH). <tb> EMI60.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 1 <SEP> H <SEP> OH <SEP> CH2COOH <SEP> 0.120 <SEP> 0.093 <SEP> g. <SEP> 376.2608 <SEP> 0.83 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (0.257 <SEP> (97%) <SEP> (M+), <SEP> 1.24 <SEP> (s, <SEP> gem <SEP> dimethyl), <tb> mM) <SEP> mp: <SEP> 85- <SEP> 358, <SEP> 291, <SEP> 2.88 <SEP> (m, <SEP> benzylic <SEP> methine), <tb> 87 <SEP> C. <SEP> 273, <SEP> 213, <SEP> 3,70 <SEP> (m, <SEP> carbinol <SEP> methine), <tb> (ether) <SEP> (b) <SEP> 6,76 <SEP> (m, <SEP> ArH) <SEP> and <SEP> 7.04 <SEP> (d, <tb> J=8Hz, <SEP> ArH). <tb> (CDCl3 <SEP> + <SEP> D6-DMSO) <tb> 2 <SEP> =O <SEP> CH2CH2CH2OH <SEP> 0.960 <SEP> 0.550 <SEP> g. <SEP> 3571, <SEP> 388.3011 <SEP> 0.82 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (2.01 <SEP> (71%) <SEP> 3333, <SEP> (M+), <SEP> 1.20 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 3.70 <tb> mM) <SEP> an <SEP> oil <SEP> 1701, <SEP> 370, <SEP> 329, <SEP> (m, <SEP> alcohol <SEP> methylene), <SEP> 6,78 <tb> 1626, <SEP> 303, <SEP> 285, <SEP> (m, <SEP> ArH) <SEP> and <SEP> 6,98 <SEP> (d, <SEP> J=8Hz. <tb> 1577 <SEP> 273, <SEP> 233, <SEP> ArH). <tb> 203, <SEP> 161, <tb> 148, <SEP> 147, <tb> 137, <SEP> 135, <tb> (c) <tb> 2 <SEP> H <SEP> OH <SEP> CH2CH2CH2OH <SEP> 4,7 <SEP> 0.50 <SEP> g. <SEP> 3534, <SEP> 390.3136 <SEP> 0.82 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (9,79 <SEP> (13%) <SEP> 3311, <SEP> (M+), <SEP> 372, <SEP> 2.65 <SEP> (m, <SEP> benzylic <SEP> methine), <tb> mM) <SEP> mp: <SEP> 114- <SEP> 1610, <SEP> 329, <SEP> 305, <SEP> 3,40 <SEP> (m, <SEP> alcohol <SEP> methylene), <tb> 116 <SEP> C. <SEP> 1575 <SEP> 287, <SEP> 257, <SEP> 3,85 <SEP> (m, <SEP> carbinol <SEP> methine), <tb> (pentane) <SEP> 246, <SEP> 233, <SEP> 6.15 <SEP> (bs, <SEP> OH), <SEP> 6.75 <SEP> (m, <SEP> ArH) <tb> 161, <SEP> 147, <SEP> and <SEP> 6.98 <SEP> (d, <SEP> J=8Hz, <SEP> ArH). <tb> (d) <tb> EMI61.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 2 <SEP> H <SEP> OH <SEP> CH2CH2CH2OH <SEP> 4.2 <SEP> 1.49 <SEP> g. <SEP> 3333, <SEP> 390.3132 <SEP> 0.80 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (8.75 <SEP> mM) <SEP> (44%) <SEP> 1626, <SEP> (M+), <SEP> 1.22 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 3.20 <tb> mp: <SEP> 57- <SEP> 1603, <SEP> 372, <SEP> 305, <SEP> (m, <SEP> benzylic <SEP> methine), <SEP> 3,50 <tb> 60 <SEP> C. <SEP> 1572 <SEP> 287, <SEP> 257, <SEP> (m, <SEP> alcohol <SEP> methylene), <SEP> 4.22 <tb> (pentane) <SEP> 233, <SEP> 161, <SEP> (m, <SEP> carbinol <SEP> methine), <SEP> 6.7147, <SEP> 135 <SEP> 7.2 <SEP> (m, <SEP> ArH). <tb> (d) <tb> 2 <SEP> H <SEP> OH <SEP> CH2CH2CH2OH <SEP> 0.778 <SEP> 0.466 <SEP> g. <SEP> 390.3130 <tb> (1.62 <SEP> (74%) <SEP> (M+), <SEP> 372, <tb> Enantiomer <SEP> A <SEP> mM) <SEP> mp: <SEP> 90- <SEP> 305, <SEP> 287, <tb> 92 <SEP> C. <SEP> 257, <SEP> 233, <tb> (pentane) <SEP> 161, <SEP> 147, <tb> (d), <SEP> (e) <tb> 2 <SEP> H <SEP> OH <SEP> CH2CH2CH2OH <SEP> 0.686 <SEP> 0.447 <SEP> g. <SEP> 390.3095 <tb> Enantiomer <SEP> B <SEP> (1.43 <SEP> (80%) <SEP> (M+), <SEP> 372, <tb> mM) <SEP> an <SEP> oil <SEP> 305, <SEP> 287, <tb> 257, <SEP> 233, <tb> 161, <SEP> 147 <tb> (d), <SEP> (f) <tb> EMI62.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 1 <SEP> H <SEP> OH <SEP> CHO <SEP> 1.00 <SEP> 0.385 <SEP> g. <SEP> 3508, <SEP> 346.2540 <SEP> 0.82 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (2.29 <SEP> (49%) <SEP> 3322, <SEP> (M+), <SEP> 1.24 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 3,8 <tb> mM) <SEP> mp: <SEP> 100- <SEP> 1612, <SEP> 328, <SEP> 261, <SEP> (m, <SEP> carbinol <SEP> methine), <SEP> 5.0102 <SEP> C. <SEP> 1562 <SEP> 243 <SEP> 5,5 <SEP> (two <SEP> m, <SEP> hemiketal <SEP> meth (ether, <SEP> (g) <SEP> (i) <SEP> ine) <SEP> and <SEP> 6,8-7.2 <SEP> (m, <SEP> ArH). <tb> entane) <tb> 1 <SEP> H <SEP> OH <SEP> CH=NOH <SEP> 0.500 <SEP> 0.362 <SEP> g. <SEP> 3533, <SEP> 361(M+), <SEP> 0.83 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (1.11 <SEP> (91%) <SEP> 3279, <SEP> 343, <SEP> 328, <SEP> 1.25 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 6,85 <tb> mM) <SEP> a <SEP> solid <SEP> 1612, <SEP> 311, <SEP> (m, <SEP> ArH) <SEP> and <SEP> 7.06 <SEP> (d, <SEP> J=8Hz, <tb> glass <SEP> 1562 <SEP> 361.2612 <SEP> ArH). <tb> (g) <SEP> (M+) <tb> (h) <tb> 1 <SEP> H <SEP> OH <SEP> CH=NOH <SEP> 1,80 <SEP> 1.28 <SEP> g. <SEP> 3508, <SEP> 361 <SEP> (M+), <SEP> 0.82 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (3,99 <SEP> (89%) <SEP> 3257, <SEP> 345, <SEP> 343, <SEP> 1.22 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 4.23 <tb> mM) <SEP> a <SEP> solid <SEP> 1613, <SEP> 328, <SEP> 311, <SEP> (m, <SEP> carbinol <SEP> methine), <SEP> 6,85 <tb> glass <SEP> 1562 <SEP> 258 <SEP> (m, <SEP> ArH) <SEP> and <SEP> 7.08 <SEP> (d, <SEP> J=8Hz, <tb> ArH). <tb> EMI63.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> A <SEP> B <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 1 <SEP> H <SEP> OH <SEP> CH2CH2CH2OH <SEP> 0.500 <SEP> 0.197 <SEP> g. <SEP> 390.3100 <SEP> 0.85 <SEP> (m), <SEP> 1.22 <SEP> (s, <SEP> gem <SEP> di (0.847 <SEP> (58%) <SEP> (M+), <SEP> methyl), <SEP> 3.20 <SEP> (OCH3), <SEP> 2.4mM) <SEP> mp: <SEP> 72- <SEP> 372, <SEP> 286, <SEP> 4.2 <SEP> (several <SEP> m), <SEP> 5.05 <SEP> (bs, <tb> 74 <SEP> C. <SEP> 272, <SEP> 147 <SEP> OH), <SEP> 6,8 <SEP> (m, <SEP> ArH), <SEP> 7.02 <SEP> (d, <tb> (pentane) <SEP> (j) <SEP> J=8Hz, <SEP> ArH). <tb> 1 <SEP> H <SEP> OH <SEP> CH2)3-O-CH2C6H5 <SEP> 3.00 <SEP> Quanti- <SEP> 3448, <SEP> 376 <SEP> (M+), <tb> (k) <SEP> (5.40 <SEP> tative <SEP> 3226, <SEP> 358, <SEP> 304, <tb> mM) <SEP> 1626, <SEP> 291, <SEP> 273 <tb> 1592 <tb> (a) HRMS, (M+) Calc'd. for C24H40O3: 376.2967 (b) HRMS, (M+) Calc'd. for C23H36O4: 376.2613 (c) HRMS, (M+) Calc'd. for C25H40O3: 388.2973 (d) HRMS, (M+) Calc'd. for C25H42O3: 390.3129 (e) [&alpha;]DCH3OH, 25 C. = -24.13 (f) [&alpha;]DCH3OH, 25 C. = +23.83 (g) Spectral data shows product exists largely in the tautomeric form but acts chemically as the product reported in the table. (h) HRMS, (M+) Calc'd. for C22H35NO3: 361.2600 (i) HRMS, (M+) Calc'd. for C22H34O3: 346.2499 (j) HRMS, (M+) Calc'd. for C25H42O3: 390.3123 (k) Reactant = cis-(3-[2-benzyloxy4-[(1,1-dimethylheptyl) phenyl]trans-4-(3-benzyloxypropyl) cyclohexanol, enantiomer A of Example 38. R2 is, of course, debenzylated to (CH2)3OH. EXAMPLE 7 Trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl) phenyl]-4-(2-propenyl)cyclohexanone ethylene ketal A mixture of 17.0 g. (38.1 mmoles) of trans-3 [2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(2-propenyl)cyclohexanone, 47.2 g. (0.762 mole) ethylene glycol and 250 mg. of c-toluenesulfonic acid monohydrate in 200 ml. of benzene was heated at reflux for 3 hours with a Dean Stark trap. The reaction was cooled and added to 200 ml. 1N sodium hydroxide, 100 ml. ether and 100 ml. pentane. The organic extract was washed twice with 200 ml. portions of water, twice with 200 ml. portions of saturate sodium chloride, dried over magnesium sulfate and evaporated (aspirator) giving a quantitative yield of the title compound. IR (CHCI3) 1656, 1626 and 1587 cm 1. MS (m/e) 490 (M+), 475, 450, 449, 448, 446, 407, 405, 399, 383 and 91. #TMS 0.82 (m, terminal methyl), 1.22 (s, gem dimethyl), 3.1 (m, benzylic methine), 3.90 (s, ethylene ketal), 4.6-5.0 and 5.2-6.0 (m, vinyl H), 5.07 (s, benzylic methylene), 6.81 (d, J=2Hz, ArH), 6.81 (dd, J=8 and 2Ez, ArH) and 7.02 (d, J=8Hz, ArH). In like manner, 4.5 g. (9.8 mmole) of trans-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(2-propenyl)cycloheptanone is converted in- quantitative yield to trans-3-[2-benzyloxy-4-(1,l dimethylheptyl)phenyl3-4- (2-propenyl)cyclcheptanone ethylene ketal, an oil. IR (CHCI1) 1650, 1613, 1550, 1504 and 1460 cm-1. + MS (m/e) 504 (M PMR 6TMS 0.80 (m, terminal methyl), 1.22 (s, gem CDCI3 d=nethyl), 3.20 (m, benzylic methine), 3.80 (bs, ethylene) 4,6-6.0 (m, olefinic), 5.07 (s, benzylic methylene), 6.85 (m, ArH), 7.02 (d, J=8Hz, ArH) and 7.38 (m, PhH). The following compounds are prepared from appropriate cycloalkanone reactants in like manner: EMI65.1 EMI65.2 <tb> S <SEP> R2 <SEP> R2,, <SEP> Z-W <SEP> <tb> 1 <SEP> -CH2-CH=CH2 <SEP> CH3 <SEP> C(CH3)2(CH2)5CH3 <SEP> <tb> 2 <SEP> -CH2-CH=CH2 <SEP> H <SEP> OCH(CH3)(CH2)3C6H5 <SEP> <tb> 2 <SEP> -CH2-CH=CH2 <SEP> H <SEP> C(CH3)2(CH2)5CH3 <tb> EXAMPLE 8 Trans-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl] 4-(3-hydroxyproyl)cyclohexanone A mixture of 4.0 g. (9.56 mmoles) of trans-3-[4- (1,l-dimethylheptyl)-2-hydroxyphenyl]-4-(3-hydroxypropyl)cyclohexanone ethylene ketal, 50 ml. of 2N hydrochloric acid and 100 ml. of tetrahydrofuran was heated at reflux for 2 hours. The reaction was cooled and added to 500 ml. saturated sodium chloride and 250 ml. ether. The ether extract was separated and washed once with 500 ml. saturated sodium chloride, once with 500 ml. saturated sodium bicarbonate, dried over magnesium sulfate and evaporated (aspirator) to an oil. The crude oil was purified via column chromatography on 200 g. of silica gel eluted with 80% ether-hexane to yield 2.93 g. (82%) of the title compound as an oil. IR (CHC13) 3521, 3333, 1709, 1616 and 1567 con 1 + MS (m/e) 374 (M ), 356, 289, 273, 247, 203 and 161. TMS FMR # CDCI3 0.82 (m, terminal methyl), 1.28 (s, gem dimethyl), 3.76 (m, alcohol methylene), 6.8 (;n, ArH) and 6.99 (d, J=8Hz, ArH. In like manner the following compounds are prepared from appropriate ketals: EMI66.1 EMI67.1 Reactant <SEP> Product <tb> IR <SEP> (CHCl3) <SEP> #TMS <tb> s <SEP> R1 <SEP> R2 <SEP> Gms. <SEP> Yield <SEP> cm-1 <SEP> MS(m/e) <SEP> PMR <tb> CDCl3 <tb> 1 <SEP> C7H7 <SEP> CH2CH2OH <SEP> 1.00 <SEP> Quanti- <SEP> 3509, <SEP> 450(M+), <tb> (2.03 <SEP> tative <SEP> 1733, <SEP> 365, <SEP> 363, <tb> mM) <SEP> an <SEP> oil <SEP> 1626, <SEP> 359, <SEP> 273, <tb> 1587 <SEP> 91 <tb> 1 <SEP> C7H7 <SEP> CH2-CH-CH3 <SEP> 0.680 <SEP> Quanti- <SEP> Rf=0.20 <SEP> (0.25 <tb> Diastereomer <SEP> A <SEP> (1.33 <SEP> tative <SEP> mm <SEP> silica <SEP> gel, <tb> mM) <SEP> an <SEP> oil <SEP> 66% <SEP> etherpentane) <tb> 0.980 <SEP> Quanti- <SEP> Rf=0.20 <SEP> (0.25 <tb> 1 <SEP> C7H7 <SEP> CH2)-CH-CH3 <SEP> (1.92 <SEP> tative <SEP> mm <SEP> silica <SEP> gel, <tb> OH <SEP> mM) <SEP> an <SEP> oil <SEP> 66% <SEP> ether Diastereomer <SEP> BO <SEP> 0.400 <SEP> Quanti- <SEP> 0.82 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (0.692 <SEP> tative <SEP> 1.23 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 5.06 <tb> (a) <SEP> mM) <SEP> an <SEP> oil <SEP> (s, <SEP> benzylic <SEP> methylene), <SEP> 6,88 <tb> (m, <SEP> ArH), <SEP> 7.03 <SEP> (d, <SEP> J=8Hz, <tb> ArH), <SEP> 7,36 <SEP> (bs, <SEP> PhH) <SEP> and <SEP> 9.58 <tb> (t, <SEP> J=2Hz, <SEP> CHO). <tb> 0.967 <SEP> g. <SEP> 3571, <SEP> 470 <SEP> (M+) <SEP> 0.80 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> 2 <SEP> C7H7 <SEP> CH2CH2CH2OH <SEP> 3,5 <SEP> 0.967 <SEP> g. <SEP> 3571, <SEP> 478 <SEP> (M+) <SEP> 0.80 <SEP> (m, <SEP> terminal <SEP> methyl), <tb> (8.1 <SEP> (31%) <SEP> 3425, <SEP> 1.27 <SEP> (s, <SEP> gem <SEP> dimethyl), <SEP> 2.7mM) <SEP> an <SEP> oil <SEP> 1695, <SEP> 3.6 <SEP> (m, <SEP> alcohol <SEP> methylene <SEP> and <tb> 1613, <SEP> benzylic <SEP> methine), <SEP> 5.02 <SEP> (s, <tb> 1577 <SEP> benzylic <SEP> methylene), <SEP> 6.9 <SEP> (m, <tb> ArH) <SEP> and <SEP> 7.4 <SEP> (m, <SEP> PhH). <tb> (a) Reactant used as bis ethylene ketal. EXAMPLE 9 Trans-3-(2-Benzyloxy-4-(1,1-dimethylheptyl) phei-4- (2-oxoethyl) cyclohexanone ethylene ketal A mixture of 17.0 g. (34.7 mmoles) of trans-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(2-propenyl)cyclohexanone ethylene ketal, 44.5 g. (0.208 mmole) of sodium metaperiodate and 176 mg. (0.69 =ole) of osmium tetroxide in 340 ml. tetrahydrofuran and 100 ml. of water was stirred at room temperature for 3.5 hours. The reaction mixture was then added to 1000 ml. 15% sodium sulfite-1000 ml. ether. The organic phase was separated, washed twice with 500 ml. of saturated sodium bicarbonate, dried over magnesium sulfate and evaporated (aspirator). The residue was purified by cold chromatography on 400 g. of silica gel eluted with 33-75% ether-petroleum ether to yield 10.0 g. (59%) of the title compound as an oil. IR ( CHCI3) 1730, 1621 and 1577 cm 1, MS (m/e) 492 (M+), 464, 448, 407, 401, 357, 339, 332, 319, 317, 271 and 91. @@, TMS 0.83 (m, terminal methyl), 1.23 (s, gem dimethyl), 3.2 (m, benzylic methine), 3.94 (s, ethylene ketal), 5.10 (s, benzylic methylene), 6.85 (dd, J-8 and 2Hz, ArH), 6.85 (d, J=2Hz, ArH), 7.07 (d, J=8Hz, ArH) and 9.57 (t, J=1.5Hz, CHO). Further elution gave 5.53 g. of-a mixture of two compounds. This mixture was dissolved in 500 ml. of ether and washed with four 250 ml. portions of IN sodium hydroxide. The ether phase was dried over magnesium sulfate and evaporated (aspirator) to yield 2.7 g. of oil. This oil was further purified via colon chromatography on 100 g. of silica gel eluted with 50% etherpentane to yield 2.16.g. (128) of trans-3-[2-benzyloxy- 4-(1,1-dimethylheptyl)phenyl]-4-(3-hydroxy-2-oxopropyl) cyclohexanone ethylene ketal as an oil. The basic extract from above was acidified with ice cold 6N hydrochloric acid and then extracted with 500 ml. of ether. The ether extract was washed twice with 200 ml. water, once with 100 ml. saturated sodium chloride, dried over magnesium sulfate and evaporated to give 2.4 g. of oil which was purified by column chromatography on 100 g. of silica gel eluted with 33% ethyl acetate-pentane to yield 1.51 g. (9%) of trans-3-[2-benzyloxy-4-(1,1 dimethylheptyl)phenyl]-4-(2-carbOxymethyl)cyclohexanone ethylene ketal. Trans-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl] 4- (3-hydroxy-2-oxopropyl) cyclohexanone ethylene ketal: IR (CHCI3) 3484, 1724, 1613 and 1575 cm 1 MS (m/e) 522 (M+), 491, 448, 432, 407, 358, 99, 91 and 86. PMR TMS 0.82 (terminal methyl), 1.22 (s, gem @@3 dimethyl), 2.17 (m, methylene a to ketone), 2.88 (t, J=5Hz, OH), 3.82 (d, overlaps 3.90), 3.90 (s, ethylene), 5.08 (s, benzylic methylene), 6.83 (m, ArH), 7.02 (d, J=8Hz, ArH) and 7.40 (m, PhH). Trans-3-[2-benzyloxy-4-(1,l-dimethylheptyl)phenyl3- 4- (2-carboxymethyl) cyclohexanone ethylene ketal: IR (CHCI3) 3636-2273 (broad), 1724, 1621 and 1582 cm-1. MS (m/e) 508 (M+), 449, 424, 418, 408, 402, 99, 91 and 86. TMS PMR # CDCI2 0.82 (m, terminal methyl), 1.22 (s, gem dimethyl), 3.2 (m, benzylic methine), 3.93 (s, ethylene), 5.10 (s, benzylic methylene), 6.85 (m, ArH), 7.10 (d, Jz8Hz, ArH) and 7.41 (m, PhH). Similarly, oxidation of 2.60 g. (5.80 mmole) of cis-3-{2-benzyloxy-4-(ltl-dimethylheptyl)phenyl]-tr2ns- 4-(2-propenyl)cyclohexanol gave 1.4 g. (54%) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4 (2-oxoethyl)cyclohexanol; 409 mg. (15%) of cis-3-t2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans- 4-(3-hvdroxy-2-oxopropyl)cyclohexanol and 120 mg. (4.9%) cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl-trans-4 (carboxymethyl) cyclohexanol. 2 -Oxoe thyl compound: IR (CHC13) 3610, 3425, 1623 and 1582 cm 1 MS (m/e) 450 (M+), 422, 405, 365, 359, 342 and 91. PMR#TMS 0.82 (m, terminal methyl), 1.23 (s, gem CDCl3 dimethyl), 3.00 (m, benzylic methine), 3.70 (m, carbinol methine), 5.09 (s, benzylic methylene), 6.88 (d, J=2Hz, ArH), 6.88 (dd, J=8 and 2Hz, ArH), 7.10 (d, J=8Hz, ArH), 7.40 (s, PhH) and 9.53 (t, J=1.5Hz, CHO). e-Hydroxy ketone: IR (CHCI3) 3448, 1721, 1618 and 1580 cm-1 MS (m/e) 480 (M+), 466, 450, 449, 406 and 91. TMS PMR # 0.82 (m, terminal methyl), 1.22 (s, gem CDCI2 dimethyl), 3.75 (m, carbinol methine), 3.86 (bs, hydroxymethylene), 5.08 (s, benzylic methylene), 6.95 (m, ArH), 7.05 ( (d, J=8Hz, ArH) and 7.38 (s, PhH). Acid: Rf = 0.32 (0.25 mm, silica gel ether). In like manner, 3,4-trans, 4,5-trans-3-[2-benzyl- oxy-1-(1,1-dimethylkeptyl)phenyl]-5-methyl-4-(2-pro- penyl)cyclohexanone ethylene ketal is oxidized to the corresponding 4- (2-oxoethyl) cyclohexanone derivative. Also produced are the corresponding 4-(3-hydroxy-2- oxopropyl)- and the 4-(2-carboxymethyl) cyclohexanone derivatives. EXAMPLE 10 Trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] 4- (5-oxopent-2-enyl) cyclohexanone bis ethylene ketal To a 150 C. solution of 4.05 mmole of sodium dimsylate in 6 ml. of dimethyl sulfoxide is added 1.61 g. (4.05 mmole) of 2- (1, 3-dioxolan-2-yl)ethyltriphenylphos- phonium bromide. The reaction mixture was stirred for 15 minutes and then a solution of 1.0 g. (2.03 mmole) of trans-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4 (2-oxoethyl)cyclohexanone ethylene ketal in one ml. of dimethyl sulfoxide was added. The reaction was stirred for 10 minutes and then added to a mixture of 200 ml. saturated sodium chloride and 200 ml. ether with stirring. The ether phase was separated and washed twice with 200 ml. of saturated sodium chloride, dried over magnesium sulfate and evaporated to an oil. The crude product was purified via column chromatography on 60 g. of silica gel eluted with 30% ether-pentane to yield 359 mg. (3' ) of the title compound as an oil. IR (CHC13) 1600 and 1563 cm 1. MS (m/e) 576 (M+). PMR #TMS 0.82 (m, terminal methyl), 1.24 (s, gem 3 dimethyl), 2.25 (m, methylene), 3.2 (m, benzylic methine), 3.85 (m, ethylenes), 4.80 (t, J=5Hz, dioxolane methine), 5.08 (s, benzylic methylene), 5.42 (m, olefinic H), 6.85 (m, ArH), 7.09 (d, J=8Hz, ArH) and 7.4 (m, PhH). In like -maner, 3,4-trans, 4,5-trans-3-±2-ben:yl- OXY-4-(1,1-dimethylheptyl)phenyl]-5-methyl-4-(2oxoethyl)cyclohexanone ethylene ketal and cis-3-[2 benzyloxy-4-(R)-(l-methyl-4-ohenylbutoxy)phenyl]-4- trans- (2-oxoethyl) cycloheptanone ethylene ketal are converted to the corresponding 4-(5-oxopent-2-enyl)- bis ethylene ketals. EXAMPLE 11 Trans-3-12-3enzyloxy-4-(1,l-dimethylheptyl)pnenyll¯4¯ (5-oxopentyl)cyclohexanone bis ethylene ketal A mixture of 520 mg. (0.902 mmole) of trans-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4- (5-oxopent-2enyl)cyclohexanone bis ethylene ketal and 100 ing. of 58 Pd/C/50% water in 15 ml. of ethanol was stirred under one atmosphere of hydrogen gas until one equivalent of hydrogen was absorbed. The reaction was filtered through diatomaceous earth and evaporated to give a quantitative yield of the title compound as an oil. TMS PMR # 0.80 (m, terminal methyl), 1.32 (s, gem CDCI3 dimethyl), 3.9 (m, ethylenes), 4.78 (, dioxolane methine), 5.08 (s, benzylic methylene), 6.85 (m, ArH), 7.08 (d, J=8Hz, ArH) and 7.42 (m, PhH). Deketalization according to the procedure of Example 8 affords the corresponding (5-oxopentyl)cycloalkanone as an oil. PMR #TMS 0.82 (m, terminal methyl), 1.23 (s, gem CDCl3 dimethyl), 5.06 (s, benzylic methylene), 6.88 (m, ArH), 7.03 (d, J=BHz, ArH), 7.36 (bs, PhH) and 9.58 (t, J=2Hz, CHO). The remaining products of Example 10 are reduced and deketalized in like manner to the corresponding 5oxopentyl ketones. EXAMPLE 12 Trans-3- t2-Benzyloxy-4-(lt l-dimethylheptyl) phenyl] 4-(2-hydroxypropyl)cyclohexanone ethylene ketal Diastereomers A and B To a 0 C. solution of 1.72 ml. (5.00 mmole) of methyl magnesium iodide (2.9M in 5 ml. of ether) was added a solution of 2.0 g. (4.06 mmole) of trans-3 [2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(2-oxoethyl)cyclohexanone ethylene ketal in 5 ml. of ether. The reaction was stirred 30 minutes and then added to 250 ml. saturated ammonium chloride and 250 ml. ether. The organic extract was washed with 250 ml. of saturated sodium chloride, dried over magnesium sulfate and evaporated to an oil, The crude oil was purified via high pressure liquid chromatography on four 60 cm x 9.5 mm Porasil B (a form of silica gel available from Waters Associates, Milford, Mass., U.S.A.) columns eluted with 50% ether-hexane to yield in order of elution 746 mg. (36%) of diastereomer A of the title compound and 935 mg. (45%) of diastereomer B of the title compound. Diastersomer A : IR (CHCI3) 3571, 3472, 1613 and 1575 cm-1 MS (m/e) 508 (M+). TMS PMR # CDCI3 0.85 (m, sidechain methyl), 1.06 (d, J=6Hz, methyl), 1.26 (s, gem dimethyl), 3.0 (m, benzylic methine), 3.7 (m, carbinol methine), 3.98 (s, ethylene), 5.02 (s, benzylic methylene), 6.81 (d, J=2z, ArH), 6.81 (dd, J=8 and 2Hz, ArH), 7.08 (d, J=8Hz, ArE) and .7.37 (m, PhH). Diastereomer B: IR (CHC13) 3610, 3460, 1618 and 1575 cm 1. MS (m/e) 508 (M+). PMR TMS 0.85 (m, sidechain methyl), 0.99 (d, J=6Hz, aCDCl3 methyl), 1.27 (s, gem dimethyl), 3.1 (m, benzylic methine), 3.55 (m, carbinol methine), 6.82 (m, ArH), 7.04 (d, J=8Hz, ArH) and 7.35 (m, PhH). EXAMPLE 13 Trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] cis-4-(2-propenyl)cycloheptanol To a refluxing solution of 3.0 g. (0.0789 mole) of sodium borohydride in 50 ml. of isopropanol was added a solution of 5.0 g. (0.011 mole) of trans-3-(2-benzyloxy- 4-(1,1-dimethylheptyl)phenyl]-4-(2-propenyl)cycloheptanone in 50 ml. of isopropanol over a 1.5 hour period. The reaction was heated one hour longer, cooled and then added to 500 ml. saturated sodium chloride. The quench was extracted twice with 800 ml. saturated ether, the extracts combined, dried over magnesium sulfate and evaporated (aspirator) to an oil. The crude oil was purified via column chromatography on 500 g. of silica gel eluted with 15% ether-hexane to yield in order of elution 1.78 g. (36%) of the title compound, 0.55 g. (11%) of mixture and 1.84 g. (36%) of the cis 3-trans-4 isomer of the title compound as oils. Cis, trans isomer: IR (CHC13) 3333, 1626, 1600 and 1563 cm 1, MS (m/e) 462 (M+) and 91. TMS PMR # CDCI2 0.82 (m, terminal methyl), 1.22 (s, gem dimethyl), 2.70 (m, benzylic methine), 3.70 (m, carbinol methine), 4.5-5.0 and 5.1-6.0 (m, olefinic), 5.03 (s, benzylic methylene), 6.75 (m, ArH), 7.02 (d, J=8Hz) and 7.34 (s, PhH). Title compound: IR (CHC13) 3571, 1642, 1613 and 1575 cm1. MS (m/e) 462 (M+) and 91. TMS PMR # CDCI3 0.80 (m, terminal methyl), 1.22 (s, gem dimethyl), 4.6-5.0 and 5.2-6.0 (m, olefinic H), 5.02 (s, benzylic methylene), 6.88 (m, ArH), 7.03 (d, J=8Hz, ArH) and 7.30 (bs, PhH). EXAMPLE 14 Cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl] trans-4-(2-propenyl)cycloheptyl d-mandelate Diastereomer A & B A mixture of 2.2 g. (4.76 mmole) of cis-3-[2benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(2 propenyl)cycloheptan6l, 869 mg. (5.72 mmole) of d-mandelic acid and 110 mg. (0.579 mmole) of ±-toluenesulfonic acid monohydrate in 40 ml. of benzene was heated at reflux for 7 hours. Water was removed via a soxhlet extractor filled with a synthetic crystalline aluminosilicate (molecular sieve) such as those distributed by the Linde Company or the Davison Chemical Company. The reaction was stirred at 250 C. for 9 hours and then added to 300 ml. of saturated sodium bicarbonate and 300 ml. ether. The ether phase was separated and washed once with 300 ml. of saturated sodium bicarbonate, dried over magnesium sulfate and evaporated (aspirator) to an oil. The crude oil was purified via column chromatography on silica gel eluted with 15% ether-hexane to yield in order of elution 1.08 g. (38%) of diastereomer A of the title compound, 0.233 g. (8%) of mixture and 1.12 g. of diastereomer B of the title compound as an oil. Diastereomer A: .m.p.: 86-90 C. (Methanol) HRMS (m/e) 596.3883 (M , calc'd. for C40H52O4: 596.3852), 444, 359, 354, 313, 269 and 91. PMR # TMS 0.82 (m, terminal methyl), 1.22 (s, gem 3 dim ethyl), 2.90 (m, benzylic methine), 3.45 (m, ester methine), 4.5-6.0 (m, olefinic and mandelate H), 5.06 (s, benzyl ether methylene), 6.90 (m, ArH) and 7.38 (m, PhH). [a]CH3OH, 25 C. = +4.42 Diastereomer B: HRMS (m/e) 596.3855 (M+, calc'd. for C40H52O4: 596.3852), 354, 269, 107 and 91. TMS PMR # 0.82 (m, terminal methyl), 1.21 (s, gem dimethyl), 2.80 (m, benzylic methine), 3.40 (m, ester methine), 4.5-6.0 (m, olefinic and mandelate H), 6.80 (m, ArH) and 7.25 (m, PhH). [&alpha;]CH3OH, 25 C. =+53.34 EXAMPLE 15 ciS-3- [2-Benzyloxy-4- (1, l-dimethylheptyl) phenyl3 - trans-4- (2-propenyl) cycloheptanol Enantiomer A A mixture of 1.25 g. (2.09 mmole) of cis-3-[2 ben2yloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-t2- propenyl)cycloheptyl d-mandelate, diastereomer A, and 577 mg. (4.18 mmole) of potassium carbonate in 20 ml. methanol, 5 ml. tetrahydrofuran and 2 ml. of water was stirred at 250 C. for 20 hours. The reaction was added to 300 ml. water-250 ml. ether. The ether extract was washed once with 300 ml. saturated sodium chloride, dried over magnesium sulfate and evaporated. The crude product was purified via column chromatography on 75 g. of silica gel eluted with 33% ether-hexane to yield 650 mg. (67%) of the title compound as an oil. HRMS (m/e) 462.3482 (M+, calc'd. for C32H46O2 : 462.3490), 377, 313, 269, 233, 227 and 91. 3 CH3OH, 250C. - -20.18 In like maner 1.25 g. (2.09 liunole) of cis-3-[2benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(2-propenyl)cycloheptyl d-mandelate, diastereomer B, was converted to 383 mg. (40%) of cis-3-[2-benzyloxy-4-(l,ldimethylheptyl)phenyl]-trans-4-(2-propenyl)cycloheptanol enantiomer B as an oil. @ HRMS (m/e) 462.3543 (M+, calc'd. for C32H46O2: 462.3490), 377, 313, 269, 233, 227 and 91. [a]CH3CH, 25 C. = +16.06 EXAMPLE 16 Cis-3- [2-Hydroxy-4- (1,1-dimethylheptyl) phenyl] - trans-4- (2-aminoethyl) cyclohexanol hydrochloride A mixture of 1.00 g. (2.77 mmole) of cis-3-[2 hydroxy-4- (1 ,l-dimethylheptyl) phenyl] -trans-4- (2-oXo- ethyl)cyclohexanol, 2.31 g. (30.0 mmole) of ammonium acetate and 177 mg. (2.77 mmole) of sodium cyanoborohydride in 10 ml. of methanol was stirred for 16 hours at 250 C. The pH of the reaction was made < 2 with concentrated hydrochloric acid and the methanol evaporated on a rotovapor. The residue was dissolved in 200 ml. of water and 20 ml. of methanol and the solution washed twice with 200 ml. of ether. The aqueous phase was separated and made basic (pH > l0) with concentrated sodium hydroxide, saturated with sodium chloride and extracted with 200 ml. of ether. This ether phase was removed, dried over magnesium sulfate and evaporated (aspirator) to an oil. The oil was dissolved in dichloromethane and excess ethereal hydrogen chloride added forming an oily precipitate which crystallized from ether-ethyl acetate-ethanol (1-1-1) solution upon cooling to yield 136 mg. (12%) of the title compound. m.p.: 218-2200 C. (ether, ethyl acetate, ethanol HRMS (m/e) 361.2993 (M+, calc'd. for C23R39N02: -361.2971), 276, 259 and 241. EXAMPLE 17 Cis-3- [ 2-Benzyloxy-4- (1, l-dimethylheptyt ) Dhenyl 3 trans-4-oxomethylcyclohexanol A mixture of 14.4 g. (29.9 mmole) of cis-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-dimethoxymethylcyclohexanol, 150 ml. of 1,4-dioxane and 150 ml. of 2N hydrochloric acid was refluxed for one hour. The reaction was cooled and added to 2 liters of saturated sodium chloride. The aqueous quench was extracted twice with 300 ml. of ether and the combined ether extract washed once with saturated sodium bicarbonate, dried over magnesium sulfate and evaporated on a rotovac to give a quantitative yield o the title compound as an oil. IR (CHCI3) 3546, 3401, 1715, 1607 and 1572 cm 1. MS (m/e) 436 (M+), , 352, 345, 328, 310, 299, 259 and 91. PMR TMS 0.82 (m, terminal methyl), 1.22 (5, gem 6 dimethyl), 2.75 (m, benzylic methane), 3.65 (m, carbinol methine), 5.01 (s, benzylic methylene), 6.83 (m, ArH), 7.06 (d, J=8Hz, ArH) and 7.36 (s, PhH). Similarly, 6.3 g. (13.07 mmole) of trans-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-cis-4-dimethoxymethylcyclohexanol (contains some of the cis-3, trans-4 isomer) was converted to 2.05 g. (36%) of trans-3-[2benzyloxy-4-(1,1-dimethylheptyl)phenyl]-cis-4-oxomethylcyclohexanol and 2.2 g. (39%) of the cis-3,. trans-4 isomer. Separation was achieved via column chromatography on 120 g. of silica gel eluted with 66% ether-hexane. Trans, cis isomer: IR (CHCI3) 1715, 1607 and 1557 cm-1. MS (m/e) 436 (M+), 418, 351 328 and 91. TMS PMR # CDCI3 0.86 (m, terminal methyl), 1.28 (s, gem dimethyl), 2.7 (m, benzylic methine), 4.22 (m, carbinol methine), 5.13 (s, benzylic methylene), 6.9 (m, ArH), 7.15 (d, J=8Hz, ArH), 7.42 (bs, PhH) and 9.42 (d, J=3Hz, CHO). EXAMPLE 18 cis-3-t2-Benzyloxy-4-(1,l-dimethylheptyl)phenyl]- trans-4-oxomethylcyclohexanol oxime A mixture of 1.5 g. (3.44 mmole) of cis-3-(2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-oxomethylcyclohexanol and 358 mg. (5.15 mmole) of hydroxylamine hydrochloride in 10 ml. of pyridine was stirred at 250 C. for 24 hours. The reaction was added to one liter of 10% hydrochloric acid and extracted with 250 ml. ether. The ether extract was washed with 200 ml. saturated sodium bicarbonate, 200 ml. saturated sodium chloride, dried over magnesium sulfate and evaporated to yield 1.40 g. (90%) of the title compound as an oil. IR (CHC13) 3533, 3300, 1612 and 1572 cm-1. MS (m/e) 451 (M+), 433 and 91. TMS PMR # CDCI3 0.86 (m, terminal methyl), 1.28 (s, gem dimethyl), 2.5-4.0 (m, 3H), 5.08 (s, benzylic methylene), 6.39 (m, 1H), 6.7-7.2 (m, ArH) and 7.40 (s, PhH). In like manner trans-3-[2-benzyloxy-4-(1,1-dimethyl- heptyl) phenyl] -cis-4-oxomethylcyclohexanol oxime was prepared in 89% (1.84 g.) yield as an oil from 2.00 g. (4.59 mmole) of trans-3-[2-benzyloxy-4-(1,10-dimethyl- heptyl)phenyl]-cis-4-oxomethyloyolohexanol. JR (CHC13) 3497, 3225, 1600 and 1562 cml MS (m/e) 451 (M+), 433, 416, 362, 348 and 91. PMR #TMS 0.82 (m, terminal methyl), 1.22 (s, gem CDCl3 dimethyl), 4.13 (m, carbinol methine), 5.08 (s, benzylic methylene), 6.85 (m, ArH), 7.08 (d, J=8Hz, ArH) and 7.40 (bs, PhH). EXAMPLE 19 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] trans-4-(2-carbomethoxyethenyl)cyclohexanol To a 250 C. slurry of 242 mg. (10.1 mmole) of sodium hydride in 20 ml. tetrahydrofuran and 10 ml. dimethylformamide was added dropwise a solution of 1.83 g. (10 mmole) of methyl dimethylphosphonoacetate in 5 ml. of tetrahydrofuran. The reaction was stirred S minutes and then a solution of 2.0 g. (4.58 l ole) of cis-32-benzyloxy-4- (1, l-dimethylheptyl) phenyl] -trans- 4oxomethylcyclohexanol in 5 ml. of tetrahydrofuran was added dropwise. The reaction was stirred 15 minutes longer and then added to 700 ml. of saturated sodium chloride. The quenched reaction was extracted with 250 ml. of ether,-the extract dried over magnesium sulfate and evaporated to an oil. The crude oil was purified via column chromatography on 50 g. of silica gel eluted with 50% ether-pentane to yield 1.28 g. (58%) of the title compound as an oil. IR (CHCl3) 3389, 1709, 1650, 1610 and 1557 cm 1. MS (m/e) 492 (M+), 407, 383, 323 and 91. PMR # TMS CDCI, 0.83 (m, terminal methyl), 1.25 (s, gem dimethyl), 3.10 (m, benzylic methine) 3.62 (s, methylester), 3.62 (m, carbinol methine), 5.05 (s, benzylic methylene), 5.57 (d, J=16Hz, olefinic H), 6.85 (m, ArH), 7.05 (d,. J=8Hz, ArH) and 7.40 (s, PhH). EXAMPLE 20 Cis-3- t2-Benzyloxy-4- (1, l-dimethylheptyl) phenyla - trans-4-(2-carbamoylethenyl)cyclohexanol A mixture of 3.0 g. (6.88 mmole) of cis-3-[2benzyloxy-4-(1,1-dimethylheptyl)phenyl)-trans-4-oxomethylcyclohexanol and 2.43 g. (7.58 =ole) of carb moyl- methylenetriphenylphosphorane in 40 ml. of dichloromethane was heated at reflux for 24 hours. The reaction was concentrated and ether added to cause crystallization of triphenylphosphine oxide. The residue was purified first via column chromatography on 120 g. of silica gel eluted with ether and then on 111 g. of neutral alumina eluted with 0-100% ethyl acetate-ether to yield 2.0 g. (61%) of the title compound as an oil. IR (CHC13) 3533, 1678, 1612 and 1587 cm 1. MS (m/e) 477 (M ), 460, 386, 368 and 307. PMR #TMS 0.84 (m, terminal methyl), 1.22 (s, gem @ dimethyl), 3.05 (m, benzylic methine), 3.70 (m, carbinol methine), 5.08 (s, benzylic methylene), 5.50 (d, J=16Hz, olefinic), 6.95 (m, ArH), 7.07 (d, J=8Hz, ArH) and 7.42 (bs, PhH). EXAMPLE 21 Cis-3- [2-Hydroxy-4- (1, l-dimethylheptyl) phenyl] - trans-4-(2-carbomathoxyethyl)cyclohexanol A mixture of 1.28 g. (2.60 mmole) of cis-3-(2- benzyloxy-4-(1,l-dimethylheptyl)phenyl]-trans-4-(2- carbomethoxyethenyl)cyclohexanol and 640 mg. of 5% Pd/C/50% H20 in 20 ml. of methanol was stirred under one atmosphere of hydrogen for 75 minutes. The reaction was filtered through diatomaceous earth and the filtrate evaporated. The residue was again mixed with 640 mg. of fresh 5% Pd/C/50% H20 in 20 ml. of methanol and stirred under one atmosphere of hydrogen for 30 minutes, then filtered and evaporated as before. The residual oil was crystallized in ether-pentane to yield 540 mg. (51%) of the title compound. m.p.: 81-83 C. (ether-pentane) IR (CHCI3) 3521, 3289, 1724, 1612 and 1574 cm-1. Ms (m/e) 404 (M+), 386, 355, 332 and 319. TMS PMR # CDCI2 0.82 (m, terminal methyl), 1.22 (s, gem dimethyl), 2.65 (m, benzylic methine), 3.40 (s, methyl ester), 3.6 (m, carbinol methine), 5.7 (broad, OH), 6.75 (m, ArH) and 7.03 (d, J=8Hz, ArH). Analysis : Calc'd. for C25H40O4: C, 74.22: H, 9.97. Found: C, 73.85; H, 9.64. Similarly, cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(2-carbamoylethyl)cyclohexanol was prepared in 39% (630 mg.) yield from 2.00 g. (4.19 mmole) of cis-3- [2-benzyloxy-4- (1, l-dimethylheptyl)phenyl] trans-4- (2-carbamoylethenyl) cyclohexanol. m.p.: 152-153 C. (ethyl acetate) IR (KBr) 3267, 3095, 1661, 1618 and 1575 cm 1. MS (m/e) 389 (M+), 372, 371, 354, 353, 286, 287 and 269. PMR (CDCl3 + D6-DMSO) #TMS 0.83 (m, terminal methyl) 1.25 (s, gem dimethyl), 3.0 (m, benzylic methine), 3.70 (m, carbinol methine), 6.75 (m, ArH) and 7.03 (d, J=8Hz, ArH). Analysis: Calc'd. for C24H39N03: C, 73.99; H, 10.09; N, 3.60. Found: C, 74.10; H, 10.11; N, 3.52. EXAMPLE 22 cis-3-[2-Hydroxy-4-(1,l-dimethylheptyl)phenyl]- trans-4-(2-carboxyethyl)cyclohexanol A mixture of 1.01 g. (2.50 mmole) of cis-3-[2- hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(2carbomethoxyethyl)cyclohexanol, 25 ml. 6N sodium hydroxide and 25 ml. dioxane was heated at reflux for 40 minutes and then cooled to 0 C. and acidified with 6N hydrochloric acid. The quenched reaction was diluted with saturated sodium chloride and extracted several times with ether and then dichloromethane. The combined organic extract was evaporated and the residue recrystallized from ethyl acetate to yield 314 mg. (32%) of the title compound. m.p. : 194-195 C. (ethyl acetate) IR (RBr) 3367, 3125, 1694, 1612 and 1575cm-1. HRMS (m/e) 390.2758 (M, calc'd. for C24H3804: 390.2760), 305, 287, 269. PMR (CDCI3, D6-DMSO) #TMS 0.82 (m, terminal methyl), 1.23 (s, gem dimethyl), 3.50 (m, carbinol methine), 6.78 (m, ArH) and 7.04 (d, J=8Hz, ArH). EXAMPLE 23 Cis-3-[2-Hydroxy-4-[1,1-dimethylheptyl)phenyl] trans-4-(3-aminopropyl)cyclohexanol To a 0 C. slurry of 500 mg. (13.1 mmole) of lithium aluminum hydride in 15 ml. of tetrahydrofuran was added a solution of 460 mg. (1.18 mmole) of cis-3-[2-hydroxy- 4-(1,l-dimethylheptyl)phenyl]-trans-4-(2-carbamoylethyl)cyclohexanol in 14 ml. of tetrahydrofuran. The reaction was stirred at 250 C. for one hour and at reflux for 20 hours. The reaction was cooled to 0 C. and quenched by the addition of a 30% solution of sodium potassium tartrate. The quenched reaction was extracted with ethyl acetate, the extract dried over magnesium sulfate and evaporated to an oil. Crystallization of the residue in ether-ethyl acetate gave 390 mg. (88%) of the title compound. m.p.: 137-138 C. MS (m/e) 375 (M+), 358 and 340. PMR (CDCI3 + D6DMSO)6TMS 0.80 (m, terminal methyl), 1.22 (s, gem dimethyl), 3.34 (bs, exchangeable OH), 3.75 (m, carbinol methine), 6.75 (m, ArH) and 7.00 (d, J=8Hz, ArH). The following compounds were similarly prepared: cis-3- t2-hydroxy-4- (1, l-dimethylheptyl) phenyla - trans-4-aminomethylcyclohexanol in 43% (819 mg.) yield from 1.99 g. (5.51 mmoie) of cis-3-[2-hydroxy-4-(1,1- d imethylheptyl ) pnenyll -trans- 4-oxomethylcyclohexanol oxime. m.p.: 104-106 C. (ethyl acetate-pentane) IR (KBr) 3205, 1602 and 1572 cm-1. HRMS (m/e) 347.2853 (M+, calc'd. for C22H37N02: 347.2815), 245, 227. EXAMPLE 24 Cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]trans-4-[3-dimethylaminopropyl)cyclohexanol hydrochloride A mixture of 340 mg. (0.906 mmole) of cis-3-(2- hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-aminopropyl)cyclohexanol, 268 wl. of 37% formaldehyde and 137 p1. of formic acid was heated at 100 C. for 30 minutes The reaction was cooled and added to ether and saturated sodium bicarbonate. The ether extract was dried over magnesium sulfate and evaporated to yield an oil which was purified via column chromatography on 8 g. of silica gel eluted with 50% methanol-dichloromethane to yield 78 mg. (21%) of the free base of the title compound as a glass. PMR a TMS Q,82 (m, terminal methyl), 1.22 (s, gem ## dimethyl), 2.19 (s, N-methyls), 3.7 (m, carbinol methine), 5.55 (broad, OH), 6.75 (m, ArH) and 6.98 (d, J=8Hz, ArH). HEMS (m/e) 403.3447 (M+, 100%, calc'd. for C26H45N02: 403.3439). The above free base was dissolved in ether-e-ano1 and excess ethereal hydrogen chloride added. The solution was then evaporated and the residue crystallized from ether-dichloromethane to yield 71.8 mg. (18%) of the title compound. m.p.: 170-175 C. (ether-dichloromethane) The following compounds were prepared by the above procedure: cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl] trans-4-N, N-dimethylaminomethylcyclohexanol hydrochloride in 25% (30mg.) yield from 100 mg. (0.288 mmole) of cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4aminomethylcyclohexanol. m.p. : 202-203 C. (ether-dichloromethane) MS (m/e) 375 (M+) trans-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]cis-4-aminomethylcyclohexanol in 44% (427 mg.) yield from 1.01 g. (2.80 mmole) of trans-3- [2-hydroxy-4 (1,1-dimethylheptyl)phenyl]-cis-4-oxomethylcyclohexanol oxime. m.p.: 121-124 C. (ether-hexane) MS (m/e) 347 (M+), 330, 312, 245 and 227. EXAMPLE 25 Trans-1-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-2 '(3-hydroxypropyl)cyclohexane A mixture of 1.9 g. (5.08 mmoles) of trans-3-[2- hydroxy-4 - (1, 1-dimethylheptyl) phenyl] -2- (3-hydroxypropyl) cyclohexanone and 10.2 ml. of hydrazine hydrate in 20 ml. of ethylene glycol is heated at 1000 C. for an hour. The reaction was cooled to 600 C. and 4.05 g. (72.3 mmoles) of solid potassium hydroxide added. The resultant mixture was heated for 2 hours at 2000 C., then cooled and added to 500 ml. IN hydrochloric acid and 300 ml. ether. The ether extract was washed with 300 ml. saturated sodium chloride, 300 ml. saturated sodium bicarbonate, dried -. over magnesium sulfate and evaporated under reduced pressure (aspirator) to an oil. The crude oil was purified via column chromatography on 100 g. of silica gel eluted with 70% ether-hexane to yield 406 mg. (22) of the title compound as an oil. IR (CHC13) 3509, 3279, 1605, 1595 and 1570 cm 1. MS (m/e) 360 (M+), 345, 342, 275, 257, 233, 215, 147 and 141. PMR TMS 0.82 (m, terminal methyl), 1.25 (s, gem 3 dimethyl), 2.58 (m, benzylic methine), 3.46 (bt, J=611z, hydroxy methylene), 5.0 (broad, OH), 6.67 (d, J=2Hz, ArH), 6.79 (d, J=8 and 2Hz) and 7.02 (d, J=8Hz, ArH). Free Base: PMR (CDCI3) 6 0.82 (m, terminal methyl), 1.30 (s, gem dimethyl), 2.28 (s, N,N-dimethyl), 3.75 (m, carbinol methine), 6.9 (m, ArH) and 7.12 (d, J=8Hz, ArH). HRMS (m/e) 375.3140 (M , calc'd. for C24H41NO2: 375.3127). trans-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]- cis-4-N,N-dimethylaminomethylcyclohexanol hydrochloride in 25% (198 mg.) yield from 672 mg. (1.94 mmole) of trans-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-cis-4aminomethylcyclohexanol. m.p.: 176-178 C. PMR (CDCI3) #TMS CDCI3 0.82 (m, terminal methyl), 1.25 (m, gem dimethyl and methylenes), 4.26 (m, carbinol methine) and 6.6-7.2 (m, ArH). Free Base: IR (CHCI3) 3333, 1607 and 1563 cm 1 MS (m/e) 375 (M+), 330 and 245. EXAMPLE 27 Cis-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl] trans-4-(3-methoxypropyl)cyclohexanol To a slurry of 172 mg. (7 mmole) of sodium hydride in 15 ml. dimethylformamide was added 2.0 g. (3.60 mmole) of cis-3- [2-benzyloxy-4- (1, l-dimethylheptyl) phenyl] trans-4- (3-hydroxypropyl) -l-benzyloxycyclohexane in 15 ml. dimethylformamide. The reaction mixture was then heated at 40-50 C. for 3 hours, then cooled to 250 C. and 0.663 ml. (7.0 mmole) of dimethylsulfate was added. The resultant mixture was stirred 18 hours at 0 C. and then added to 250 ml. saturated sodium chloride and 250 ml. ether. The organic extract was dried over magnesium sulfate and evaporated to an oil. The crude oil was purified via column chromatography on 75 g. of silica gel eluted with 20% ether-hexane to yield 500 g. (24%) of cis-3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-trans4-(3-methoxypropyl)cyclohexanol as an oil. TMS PMR # CDCI3 0.83 (m, terminal methyl), 1.23 (s, gem dimethyl), 3.20 (s, OCH3), 2.6-4.0 (m), 4.54 and 5.06 (s, benzylic methylenes), 6.85 (m, ArH) and 7.28 (m, PhH). Debenzylation of 500 mg. (0.874 mmole) of the product according to the procedure of Example 6 gives the title compound. m.p.: 72 -74 C. (pentane) MS (m/e) 390.3100 (M+, calc'd. for C25H42O3; 390.3123) 372, 286, 272 and 147. PMR (CDCl3) 6 0.85 (m), 1.22 (s, gem dimethyl), 3.20 (OCH3), 2.4-4.2 (several m), 5.05 (bs, OH), 6.8 (m, ArH) and 7.02 (d, J=8Hz, ArH). EXAMPLE 26 ciS-3- [2-Benzyloxy-4- (1, l-dimethylheptyl) phenyl) - trans-4-(2-propenyl)-1-benzyloxycyclohexane To a slurry of 214 mg. (8.92 mmole) of sodium hydride in 10 ml. dimethylformamide was added a solution of 2.0 g. (4.46 mmole) of cis-3-[2-benzyloxy-4-(l,l-di- methylheptyl)phenyl]-trans-4-(2-propenyl)cyclohexanol in 10 ml. of dimethylformamide. The reaction was stirred 5 hours and then 0.6 ml. (4.9 mmole) of benzyi bromide was added. The reaction mixture was stirred 18 hours longer and added to 500 ml. saturated sodium chloride and 500 ml. ether. The organic extract was dried over magnesium sulfate and evaporated to yield an oil which was purified via column chromatography on 100 g. of silica gel eluted with 5% ether-hexane to yield 2.0 g. (839) of the title compound as an oil. IR (CHCI3) 1639, 1600 and 1567 cm 1. + HRMS (m/e) 538.3823 (M , calc'd. for C38H5002: 538.3798), 453, 299, 255 and 91. TMS PMR # CDCI3 0.83 (M, terminal methyl), 1.24 (s, gem dimethyl), 2.85 and 3.40 (m, ether methines), 4.50 and 5.05 (s, benzylic methylenes), 4.6-5.0 and 5.2-6.1 (n, vinyl H), 6.9 (m, ArH), 7.28 and 7.34 (bs, PhH). EXAMPLE 28 Trans-3-[2-Benzyloxy-4-(R)-(1-methyl-4-phenylbutoxy) phenyl]-4-(2-propenyl)cycloheptanone Using the procedure of Example 1, 23 g. (54.1 mmole) of (R) -l-bromo-2-benzyloxy-4- (1-methyl-4-phenylbutoxy) - benzene and 7.5 g. (50.0 mmole) of 4-(2-propenyl)-2cyclohepten-l-one gave 8.14 g. (30%) of the title compound as an oil. [a]25 = -10.61 (C=1.077, CHCI3) HRMS (m/e) 496.2964 (M+, calc'd. for C34H40O3 496.2967), 405, 259, 241 and 91. PMR #TMS CDCI3 1.22 (d, J=6Hz, methyl), 4.33 (m, sidechain methine), 4.6-5.0 and 5.2-6.0 (m, vinyl H), 5.00 (s, benzylic methylene), 6.45 (m, ArH), 7.00 (d, J=8Hz, ArH), 7.24 (s, PhH)and 7.42 (s, PhH). EXAMPLE 29 Cis-3-[2-Benzyloxy-4-(R)-(1-methyl-4-phenylbutoxy)phenyl]4-trans-(2-propenyl)cycloheptanol and Isomeric Alcohol Using the procedure of Example 2, 8.14 g. (16.5 mmole) of trans-3- (2-benzyloxy-4- (R)- (l-methyl-4-phenylbutoxy) phenyl]-4-(2-propenyl)cycloheptanone gives in order of elution 3.14 g. (39%) of the trans-3, cis-4 isomer and 3.23 g. (40%) of the title compound. Trans-3, Cis-4 Isomer : [&alpha;]D25 = - 10.40 (C = 1.058, CHCl3) IR (CHCl3) 3508, 3448, 1626 and 1600 cm-1. HRMS (m/e) 498.3120 (M , calc'd. for C34H4203: 498.3123) and 91. PMR #TMS CDCI3 1.22 (d, J=6Hz, methyl), 2.6 (m, benzylic methylene), 3.2 (m, benzylic methine), 4.0 (m, carbinol methine), 4.25 (m, sidechain methine), 4.6-5.0 and 5.26.0 (m, vinyl H), 5.02 (s, benzylic methylene), 6.4 (m, ArH), 7.20 and 7.38 (s, PhH). Cis-3, Trans-4 Isomer: [a]D25 = -9.97 (C=1.471, CHCI3) IR (CHCI3) 3508, 3448, 162-6 and 1600 cm-1. HRMS (m/e) 498.3104 (M+, calc'd. for C34H4203: 498.3123), 261, 243 and 91. TMS PMR # 1.22 (d, J=6Hz, methyl), 2.55 (m, benzylio CDCI3 methylene and methine), 3.65 (m, carbinol methine), 4.20 (m, sidechain methine), 4.6-5.0 and 5.2-6.0 (m, vinyl H), 5.02 (s, benzylic methylene), 6.4 (m, ArH), 7.00 (d, J=8Hz, ArH), 7.2 and 7.38 (5, PhH). EXAMPLE 30 Cis-3-[2-Benzyloxy-4-(R)-(l-methyl-4-phenylbutoxy) phenyl]-4-trans-(3-hydroxypropyl)cycloheptanol Using the procedure of Example 5, 1.03 g. (2.07 mmole) of cis-3-[2-benzyloxy-4-(R)-(l-methyl-4-phenylbutoxy)phenyl]-4-trans-(2-propenyl)cycloheptanol gave 1.08 g. (100%) of the title compound as an oil. 250 = 9.830 (C = 1.051, CHCl3) IR (CHCl3) 3571, 3389, 1600 and 1574 cm 1. HRMS (m/e) 516.3216 (M+, calc'd. for C34H44O4: 516.3228). TMS PMR # CDCl, 1.22 (d, J=6Hz, methyl), 2.7 (m, benzylic methylene), 3.42 (bt, CH2OH), 3.85 (m, carbinol methine), 4.35 (m, sidechain methine), 5.00 (s, benzylic methylene) 6.45 (m, ArH), 7.02 (d, J=8Hz, ArH), 7.25 and 7.42 (s, PhH). EXAMPLE 31 Cis-3-[2-Hydroxy-4-(R)-(1-methyl-4-phenylbutoxy) phenyl]-4-trans-(3-hydroxypropyl)cycloheptanol Using the procedure of Example 6, 1.0 g. (1.93 mmole) of cis-3- [2-benzyloxy-4- (R) - (l-methyl-4-?henylbutoxy) - phenyl]-4-trans-(3-hydroxypropyl)cycloheptanol gave 500 mg. (61%) of the title compound as an oil. [a]D25 = -7.53 (C=0.68, CHCI3) IR (CHCI3) 3508, 3333, 1600 and 1587 cm-1. HRMS (m/e) 426.2758 (M+, calc'd. for C27H38O4: 426.2760), 280, 262, 123 and 91. PMR #TMS 1.22 (d, J=6Hz, methyl), 2.58 (m, benzylic methylene), 3.40 (t, J=7Hz, CH20E), 3.8 (m, carbinol methine), 4.15 (m, sidechain methine), 6.35 (m, ArH), 6.95 (d, J=8Hz, ArH) and 7.19 (s, PhH). EXAMPLE 32 ciS-3- [2-Benzyloxy-4- (1, l-dimethylheptyl) phenyll ¯ trans-4-(Z-propenyl)-1-phthalimidocycloheptane To a 25 C. mixture of 1.00 g. (2.16 mmole) of trans-3-[2-benzyloxy-4-(1,l-dimethylheptyl)phenyl]-cis 4-(2-propenyl)cycloheptanol, 476 mg. (3.24 mmole) of phthalimide and 846 mg. (3.24 mmole) of triphenylphosphine in 1.0 ml. acetonitrile was slowly added 0.51 ml. (3.24 mmole) of diethyl azodicarboxylate. The reaction mixture was stirred 5 hours and then dissolved in 250 ml. ether. The ether phase was washed once with 250 ml. water, once with 250 ml. saturated sodium chloride, dried over magnesium sulfate and evaporated to an oil. The crude oil was purified via column chromatography on 200 g. of silica gel eluted with 10% ether-hexane to yield 820 mg. (64%) of the title compound as an oil. IR (CHCI2) 1761, 1695, 1625, 1603 and 1563. HRMS (m/e) 591.3799 (M+, calc'd. for C40H49NO3: 591.3700), 506, 353 and 91. PMR #TMS 0.8 (m, terminal methyl), 1.20 (s, gem 3 dimethyl), 2.98 (m, benzylic methine), 4,4 (bm, methine), 4.5-5.0 (m, vinyl H), 5.03 (s, benzylic methylene), 5.26.0 (m, vinyl H), 6.78 (m, ArH), 7.02 (d, J=8Hz, ArH), 7.33 and 7.65 (m, ArH and PhH). EXAMPLE 33 ciS-3- t 2-Benzyloxy-4 - (1, l-dimethylheptyl ) phenyll trans-4-(2-propenyl)-1-aminocycloheptane A solution of 1.0 g. (1.68 mmole) of cis-3-[2benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(2 propenyl) -l-phthalimidocycloheptane and 0.834 ml. (1.68 mmole of hydrazine hydrate in 2 ml. ethanol was heated at reflux for 20 minutes forming a precipitate. The -reaction was cooled, filtered and the solid washed with 200 ml. ether. The filtrate was washed once with. 100 ml. saturated sodium chloride, once with 100 ml. 50% 2N sodium hydroxide, dried over magnesium sulfate and evaporated to yield 770 mg. (99%) of the title compound as an oil. IR (CHCI2) 3125, 1695, 1632, 1600 and 1562 cm-1. HRMS (m/e) 461.3607 (M+, calc'd. for C32H47NO: 461.3646), 420, 370, 354 and 91. PMR #TMS 0.8 (m, terminal methyl), 1.24 (s, gem CDCI3 dimethyl), 2.9 (m, 2H), 4.6-5.0 (in, vinyl H), 5.04 (s, benzylic methylene), 5.2-6.1 (m, vinyl H), 6.85 (m, ArH), 7.07 (d, J=8Hz, ArH) and 7.4 (m, PhH). Following the procedures of Example 32 and of this example, cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(2-propenyl)-1-aminocyclohexane is prepared from trans-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-cis-4-(2-propenyl)cyclohexanol. EXAMPLE 34 Cis-3- [2-Benzyloxy-4- (1,l-dimethylheptylO phenyll - trans-4-(2-propenyl)-1-acetamidocycloheptane A mixture of 500 mg. (1.08 mmole) of cis-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(2- propenyl)-1-aminocycloheptane, 131 mg. (1.08 mmole) 4-N,-dimethylaminopyridine and 0.101 ml. (1.08 mmole) of acetic anhydride in 5 ml. dichloromethane was stirred for one hour. The reaction was added to 100 ml. ether and washed twice with 100 ml. 1N hydrochloric acid and twice with 100 ml. saturated sodium bicarbonate. The organic phase was dried over magnesium sulfate and evaporated to give 485 mg. (89%) of the title compound as an oil. IR (CHCI3) 3389, 1652, 1602 and 1562 cm 1. HRMS (m/e) 503.3793 (M , calc'd. for C34H49NO2: 503.3751), 418, 412, 353 and 91. PMR @ 0.82 (m, terminal methyl), 1.22 (s, gem # dimethyl), 1.86 (s, COCH3), 2.95 (m, benzylic methine), 4.02 (bm, CHN), 4.6-5.0 (m, vinyl H), 5.08 (s, benzylic methylene), 5.3-6.0 (m, vinyl H), 6.85 (m, ArH), 7.03 (d, J=8Hz, ArH) and 7.38 (m, ArH). EXAMPLE 35 cis-3-[2-33enzyloxy-4-(1,l-dimethylheptyl)phenyl]- trans-4-(3-hydroxypropyl)-1-acetamidocycloheptane Using the procedure of Example 5, 1.7 g. (3.37 mmble) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]trans-4-(2-propenyl)-1-acetamidocycloheptane gave 962 mg. (55%) of the title compound as an oil. IR (CHCI3) 3448, 1652, 1600 and 1562 cm-1. HRMS (m/e) 521.3813 (M+, calc'd. for C34H51NO3: 521.3856), 430, 371 and 91. TMS PMR # CDCI3 0.8 (m, terminal methyl), 1.20 (s, gem dimethyl), 2.85 (m, benzylic methine), 3.35 (m, CH2OH), 4.0 (m, CHN), 5.05 (s, benzylic methylene), 5.38 (bd, NH), 6.8 (m, ArH), 7.00 (d, J=8Hz, ArH) and 7.39 (bs, PhH). EXAMPLE 36 Cis-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl] trans-4-(3-hydroxypropyl)-1-acetamidocyclheptane Using the procedure of Example 6, 960 mg. (1.84 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl)trans-4-(3-hydroxypropyl)-1-acetamidocycloheptane gave 630 mg. (79%) of the title compound as an oil. IR (CHCI3) 3649, 3389, 3279, 1652,.160d and 1562 cm 1. HRMS (m/e) 431.3420 (M+, calc'd. for C27H45NO3: 431.3388), 346, 287, 257, 161, 147 and 133. #TMS 0.8 (m, terminal methyl), 1.20 (s, gem 3 dimethyl), 1.85 (s, COCH3), 2.82 (m, benzylic methine), 3-.42 (m, CH20H), 4.0 (m, CHN), 5.6 (bd, NH), 6.75 (m, ArH) and 6.98 (d, J=8Hz, ArH). By means of the procedures of Examples 34, 35 and this example, cis-3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-trans-(3-hydroxypropyl)-1-acetamidocyclohexane is prepared from cis-3-[2-benzyloxy-4-(1,1-dimethyl- heptyl)phenyl-trans-(2-propenyl)-1-aminocyclohexane. EXAMPLE 37 cis-3-[2-Benzyloxy-4-(1,l-dimethylneDtyl)phenyl]- trans-4-(3-hydroxypropyl)cyclohexanol bis-d-mandelate A mixture of 31.3 g. (67.2 mmole) of cis-3-[2benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4 (3-hydroxypropyl)cyclohexanol, 25.5 g. (168 mmole) of d-mandelic acid and 1.0 g. (5.26 mmole of p-toluenesulfonic acid monohydrate in 500 ml. of benzene was heated at reflux for 11 hours. Water was removed by use of a soxhlet extractor filled with 200 g. of 3A molecular sieves. The reaction is cooled, added to one liter saturated sodium bicarbonate and extracted with four 500 ml. portions of ether. The combined organic extract was dried over magnesium sulfate and evaporated to an oil. The crude oil was purified via column chror'..a- tography on 2 kg. of silica gel eluted with 40-50% etherhexane to yield in order or elution 18 g. (37%) of diastereomer A and 21 g. (43%) of diastereomer B of the title compound. Diastereomer A m.p.: 111-112.5 C. (methanol) 25 = + 20.19 (C=1.107, 5% chloroform-methanol) PMR (CDC13) 6 0.84. (m, terminal methyl), 1.25 (s, gem dimethyl), 2.8 (m, benzylic methine), 3.45 (m), 4.0 (m), 4.6-5.2 (m), 5.05 (s, benzylic methylene), 6.88 (m, ArH), 7.27 and 7.34 (s, PhH). Analysis: Calc'd. for C47H5807: C, 76.81; H, 7.95. Found: C, 76.49; H, 7.76. In like manner, but using the same relative stoichiometric proportion of d-mandelic acid and p-toluenesulfonic acid monohydrate, 9.0 g. (16 mmole) of CiS-3-t2-Benzyloxy-4-(1,l-dimethylheptyl)phenyl]- trans-4-(3-benzyloxypropyl)cyclohexanol gave, in order of elution, 4.1 g. (37%) of diastereomer A and 4.2 g. (38%) of diastereomer B of cis-3-[2-benzyloxy-4-(1,1- dLmethylheptyl)phenyll-trans-4-(3-benzyloxy?ropyl)-1- d-mandeloyloxycyclohexane as solids. Diastereomer A: m.p.: 56-58 C. 250 ta] = 0.2920 (C = 1.25, CH3OH) PMR #TMS 0.80 (m, terminal methyl), 1.20 (s, gem CDCI3 dimethyl), 2.9 (m), 3.0-3.6 (m), 4.30 (s, benzylic methylene), 4.5-5.1 (m), 5.00 (s, benzylic methylene), 6.78 (m, ArH), 6.98 (d, J=8Hz, ArH), 7.17 (s, PhH) and 7.30 (s, PhH). Diastereomer 3: m.p.: 65-69 C. [a]D25 = +40.95 (C = 1.21, CH3OH) PMR #TMS 0.80 (m, terminal methyl), 1.20 (s, gem CDCI3 dimethyl), 2.8 (m), 3.0-3.5 (m), 4.26 (s, benzylic methylene), 4.4-5.1 (m), 4.95 (s, benzylic methylene), 6.70 (m, ArH), 6.87 (d, J=8Hz), 7.12 (s, PhH) and 7.20 (s, PhH). EXAMPLE 38 Enantiomer A of Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(3-hydroxypropyl)cyolohexanol A mixture of 18 g. (24.5 mmole) of diastereomer A of cis-3- [2-benzyloxy-4- (l,l-dimethylheptyl) phenyl] - trans-4- (3-hydroxypropyl) cyclohexanol bis-d-mandelate and 13.5 g. (98.1 mmole) of potassium carbonate in 250 ml. methanol, 175 ml. tetrahydrofuran and 35 ml. water was stirred for 24 hours. The reaction was added to one liter saturated sodium chloride and extract twice with 500 ml. portions of ether. The combined organic extract was dried over magnesium sulfate and evaporated to a quantitative yield of the title compound as an oil. [a]D25 = -34.51 (C=1.083, methanol) TMS PMR # CDCI, 0.82 (m, terminal methanol), 1.25 (s, gem dimethyl), 2.90 (m, benzylic methine), 3.40 (bt, CH2OH), 3.7 (m, carbinol methine), 5.06 (s, benzylic methylene), 6.82 (d, J=2Hz, ArH), 6.82 (dd, J=8 and 2Hz, ArH), 7.00 (d, J=8Hz, ArH) and 7.32 (s, PhH). Using the above procedure, 4.00 g. (5.79 rn-mole) of cis-3-[2-benzyloxy-4-(1-1-dimethylheptyl)phenyl]trans-4-(3-benzyloxypropyl)-1-d-mandeloyloxycyclohexane, diastereomer A, gave a quantitative yield of cis-3- [2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3benzyloxypropyl)cyclohexanol, enantiomer A, as an oil. [a]D25 = -24.92 (C=1.23, CH3OH) PMR #TMS 0.82 (m, terminal methyl), 1.22 (s, gem dimethyl), 2.9 (m, benzylic methine), 3.23 (bt, J=6Hz, methylene), 3.7 (m, carbinol methine), 4.35 and 5.00 (s, benzylic methylenes), 6.82 (m, ArH), 7.02 (d, J=8Hz, ArH), 7.19 and 7.35 (s, PhH). EXAMPLE 39 Enantiomer B of Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)- phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol a. Using the procedure of Example 38, 21 g. (28.6 mmole) of diastereomer B of cis-3-[2-benzyloxy4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol bis-d-mandelate gave 13 g. (98%) of the title compound as on oil. [a]D25 = +26.30 (C =1.051, CH3OH) b. Using the procedure of Example 37, 13 g. (27.8 mmole) of the title compound and 10.6 g. (69.7 mmole) of l-mandelic acid gave 8 g. (39%) of diastereomer A of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans4-(3-hydroxypropyl)cyclohexenol bis-1-mandelate. m.p. . 106-107.5 C. (methanol) PMR #TMS 0.83 (terminal methyl), 1.25 (5, gem dimethyl), 2.85 (m, benzylic methine), 3.40 (m), 4.0 (m), 4.7-5.1 (m), 5.07 (s, benzylic methylene). Analysis: Calc'd. for C47H5807: C,. 76.81; H, 7.95. Found: C, 76.69; H, 7.86. c. Using the procedure of Example 38, 8.0 g. (10.9 mmole) of diastereomer A of cis-3-[2-benzyloxy- 4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol bis-l-mandelate gives 4.7 g. (93%) of the title compound. 250 = z D - +34.170 (C = 1.15, CH30H) TMS PMR # CDCI3 0.86 (m, terminal methyl), 1.28 (s, gem dimethyl)1 2.82 (m, benzylic methine), 3.42 (bt, CH2OH), 3.7 (m, carbinol methine), 5.10 (s, benzylic methylene), 6.9 (m, ArH), 7.10 (d, J=8Hz, ArH) and 7.40 (s, PhH). EXAMPLE 40 cis-3-[4-(1,l-Dimethylheptyl)-2-hydroxyphenyl]-trans- 4- (3-hydroxypropyl) cyclohexanol, Enantiomer A Using the procedure of Example 6, 11.4 g. (24.5 =ole) of enantiomer A of cis-3-[2-benzyloxy-4-(1,1- dLmethylheptyl)phenyl3-trans-4-(3-hydroxypropyl)cyclo- hexanol gave 8.5 g. (93%) of the title compound. m.p. 65-72 C. (hexane-dichloromethane) 250 @D HRMS (m/e) 376.2938 (M+, calc'd. for C24H4003: 376.2967), 304, 273, 255, 199, 147 and 121. PMR #TMS 0.83 (m, terminal methyl), 1.23 (s, gem 3 dimethyl), 2.83 (m, benzylic methine), 3.58 (bt, CH2OH), 3.7 (m, carbinol methine), 6.9 (m, ArH) and 7.00 (d, J=8Hz, ArH). EXAMPLE 41 Cis-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-trans 4-(3-hydroxypropyl) cyclohexanol, Enantiomer B Using the procedure of Example 6, 4.7 g. (10.1 mmole) of enantiomer B of cis-3-[2-benzyloxy-4-(1,1-dimethyl- heptyl) phenyl] -trans-4- (3-hydroxypropyl) cyclohexanol gave 3.5 g. (92%) of the title compound as an oil. [a]D25 = +36.47 (C=0.947, CH3OH) HRMS (m/e) 376.2942 (X+, calc'd. for C24H4003: 376.2967), 358, 291, 273 and 147. PMR (CDCl3) 6 0.82 (s, terminal methyl), 1.2 (s, gem dimethyl) 2.7 (m, benzylic methine), 3.41 (bt, J=7Hz, carbinol methylene), 3.78 (m, carbinol rnethine), 6.77 (m, ArH) and ?.00 (d, J=8Hz, ArH). EXAMPLE 42 Trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] 5-cyanocyclohexanone To a refluxing solution of 3.99 g. (9.87 mmole) of 5-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-2-cyclohexen-l-one in 6.65 ml. of ethyl acetate was added a hot solution of 800 mg. (11.9 mmole) of potassium cyanide in 2 ml. water and 2.3 ml. ethanol. The reaction was refluxed 2 hours and then another 2.74 mmole of potassium cyanide added. The reaction was refluxed one hour longer and then cooled and added to 400 ml. saturated sodium chloride-400 ml. ether. The ether extract was dried over magnesium sulfate and evaporated to yield an oil. The crude oil was purified via column chromatography on 160 g. of silica gel eluted with 10% acetone-hexane to yield 3.02 g. (71%) of the title compound. m.p. 790 C. (petroleum ether) IR (CHC13) 2202, 1706, 1600 and 1552 cm-1. MR (m/e) 431 (M+), 14, 403, 346, 340 and 91. EXAMPLE 43 Trans-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] c is-5-cyanocyclohexanol Using the procedure of Example 2, 3.02 g. (7.00 mmole) of trans-3- [2-benzyloxy-4-(l, 1-dimethylheptyl)- phenyl)-5-cyanocyclohexanone was reduced to 2.66.g. (88%) of the title compound. m.p. 94-102 C. (pentane) IR (CHCl3) 3413, 2222, 1612 and 1575 cm-1. MS (m/e) 433 (M+). EXAMPLE 44 Trans-3- [2-Benzyloxy-4- (1, l-dimethylheptyl) phenyll trans-5-cyanocyclohexanol A mixture of 3.12 g. (7.20 mmole) of trans-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-cis-5-cyanocyclohexanol and 808 mg. (7.20 mmole) of potassium t-butoxide in 70 ml. of t-butanol was refluxed for 2.5 hours. The t-butanol was evaporated on a rotovapor and the residue diluted with saturated sodium chloride. The quenched residue was extracted with ether, the extract dried over magnesium sulfate and evaporated to yield an oil. The crude oil was purified via column chromatography on 124 g. of silica gel eluted with 10% acetonehexane to yield 1.53 g. (44%) of the title compound. m.p. 62-64 C. (petroleum ether) IR (CHC13) 2247, 1597 and 1579 cm 1. MS (m/e)- 433 (M+), 348, 342, 305 and 91. TMS PMR # CDCI3 0.83 (m, terminal methyl), 2.8-3.9 (two methines), 4.25 (m, carbinol methine), 5.12 (s, benzylic methylene), 6.9 (m, ArH), 7.06 (d, J=8Hz, ArH) and 7.4 (s, PhH). EXAMPLE 45 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] 5-cyanocyclohexanone To a 0 C. solution of 1.43 g. (3.30 mmole) of trans-3- [2-benzyloxy-4- (1, 1-dimethylheptyl) phenyll trans-S-cyanocyclohexanol in 25 ml. of acetone was added 2.37 ml. (6.6' mmole) of Jones's Reagent. The reaction was stirred 20 minutes at 04 C. and then quenched by the addition of 1 ml. of isopropanol. The quenched reaction was added to 700 ml. saturated sodium chloride and extracted with 300 ml. of ether. The ether extract was dried over magnesium sulfate and evaporated to yield 1.31 g. (92%) of the title compound as an oil. IR (CHCI3) 2247, 1733, 1623 and 1584cm-1. MS (m/e) 431 (MT), 416, 404, 362, 347, 340 and 91. TMS PMR # CDCI3 0.83 (m, terminal methyl), 1.24 (s. gem dimethyl), 2.0-3.7 (m), 5.10 (s, benzylic methylene), 6.95 (m, ArH), 7.02 (d, J=8Hz) and 7.38 (s, ArH). EXAMPLE 46 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] cis-5 -cyanocyclohexanol Using the procedure of Example 2, 1.11 g. (2.58 mmole) of cis-3- (2-benzyloxy-4-(1,1-dimethylheptyl) phenyl]-5-cyanocyclohexanone gave 949 mg. (84%) of the title compound as an oil. IR (CHCI3) 3571, 3389, 2232, 1612 and 1574 cm-1. TMS PMR # CDCI3 0.83 (m, terminal methyl), 1.25 (s, gem dimethyl), 3.70 (m, carbinol methine), 5.10 (s, benzylic methylene),. 6.9 (m, ArH), 7.09 (d, J=8Hz, ArH) and 7.41 (s, PhH). EXAMPLE 47 Cis-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl] 5-cyanocyclohexanone Using the procedure of Example 6, 200 mg. (0.462 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethyl)phenyl]-5-cyanocyclohexanone was converted to 133 mg. (84%) of the title compound. m.p. 111-112 C. (ether-petroleum ether) IR (CHCl3) 3571, 3300, 2237, 1724, 1626 and 1577 cm MS (mje) 341 (M+), 256, 239 and 229. Analysis: Calc'd. for C22H31N02: C, 77.38; H, 9.15; N, 4.10. Found: C, 76.89; H, 9.05; N, 4.14. EXAMPLE 48 ciS-3- t4- (1, l-Dimethylheptyl) -2-hydroxyphenyll cis-5-cyanocyclohexanol Using the procedure of Example 6, 235 mg. (0.542 mmole) of cis-3-[2-benzyloxy-4-[1,1-dimethyl]phenyl]-cis-5-cyanocyclohexanol gave 74.5 mg. (40%) of the title compound. m.p. 165 C. (dichloromethane-petroleum ether) IR (KBr) 3225, 2232, 1618 and 1582 cm 1. MS (m/e) 343 (M+), 299, 258, 241 and 213 cm-1. PMR (CDCI3, D6-DMSO) 0.83 (m, terminal methyl), 1.22 (s, gem dimethyl), 3.65 (m, carbinol methine), 6.77 (m, ArH) and 7.00 (d, J=8Hz, ArH). Analysis : Calc'd for C22H33NO2: C, 76,92; H, 9,68; N, 4,08. Found: C, 76.51; n, 9.23; X, 3.95. EXAMPLE 49 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] 5-c is-hydroxycyclohexane carboxaldehyde To a -65 C. solution of 704 mg. (1.62 imnole) of cis-3- 2-benzyloxy-4- (1, l-dimethylhectyl) phenyl] -cis5-cyanocyclohexanol in 30 ml. toluene was added 3.40 ml. (3.4 mmole) of diisobutylaluminum hydride (IM in toluene). The reaction was allowed to warm to -5 C. and was then poured onto dilute sulfuric acid and ice. The quenched reaction was extracted with ether, the extract dried over magnesium sulfate and evaporated to give a quantitative yield of the title compound as an oil. IR (CHCI3) 3165, 1730, 1612 and 1574 cm 1. MS (m/e) 436 (M+), 408 and 350. TMS PMR # CDCI3 0.83 (m, terminal methyl), 1.23 (s, gem dimethyl), 3.7 (m, carbinol methine), 5.11 (s, benzylic methylene), 6.85 (m, ArH), 7.35 (m, PhH) and 9.60 (bs, CHO) EXAMPLE 50 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] cis-5-hydroxymethyloyclohexanol Using the procedure of Example 2, 700 mg. (1.60 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-5 cis-hydroxycyclohexane carboxaldehyde was converted to 208 mg. (30%) of the title compound as an oil. MS (m/e) 438 (M+) PMR # TMS 0.83 (m, terminal methyl), 1.23 (s, gem CDCI3 dimethyl), 2.7-4.0 (m, 4H), 5.09 (s, benzylic methylene), 6.90 (m, ArH), 7.10 (d, J=8Hz, ArH) and 7.38 (s, PhH). EXAMPLE 51 ciS-3- [4- (1, l-Dimethylheptyl) -2-hvcroxyphenyll - cis-5-hydroxymethylcycloexanol Using the procedure of Example 6, 208 mg. (0.475 mmole) of cis-3- (2-benzyloxy-4- (1,l-dimethylheptyl) phenyl] -cis5-hydroxymethylcyclohexanol was hydrogenolyzed to 127 mg. (77%) of the title compound. m.p. 126-127 C. (ether-petroleum ether) IR (CHCI3) 3597, 3333, 1623 and 1587 cm 1. HRMS (m/e) 348.2662 (M+, calc'd. for C22H3603: 348. 2655) , 330, 299, 287, 263 and 245. PMR (CDCI3, D5-DMSO) 6 0.85 (m, terminal methyl), 1.25 (s, gem dimethyl), 3.5 (m, carbinol methylene), 3.8 (m, carbinol methine), 6.8 (m, ArH) and-7.07 (d, J=8Hz, ArH). EXAMPLE 52 7-Oxabicyclo[4.1.0]-4-[2-benzyloxy-4-(1,1 dimethylheptyl)phenyl]-2-heptanone To a 0 C. solution of 3.24 g. (8.01 mole) of 5-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl)-2-cyclohexen-l-one and 2.3 ml. (24 mmole) of 305 hydrogen peroxide in 80 ml. methanol was added dropwise 0.66 ml. (3.96 mole) of 6N sodium hydroxide. The reaction was stirred one hour longer at O C. and then added to 1000 ml. saturated sodium chloride. The quenched reaction was extracted with 500 ml. of ether, the extract dried over magnesium sulfate and evaporated to yield 3.02 g. of crude product. The crude product was purified via column chromatography on 200. g. of silica gel euted wit 20% ether-petroleum ether to yield in order or elution 237 mg. (7%) of the cis isomer, 1.72 g. (51%) o= a mixture and 1.01 g. (308) of the trans isomer of title e compound. Column chromatography of the mixed fraction on 300 g. of silica gel eluted with 10% ether-petroleum ether yielded 34 mg. (1%) of cis isomer and 1.56 g. (46%) of the trans isomer of title compound, both as oils. Cis Isomer: IR (CHCI3) 1718, 1626 and 1582 cm-1. MS (m/e) 420 (M+), 404, 335, 312, 206 and 91. PMR #TMS CDCI3 0.83 (m, terminal methyl), 1.27 (s, gem dimethyl), 2.0-2.5 (m), 2.9-3.7 (m), 5.15 (s, benzylic methylene), 6.9 (m, ArH), 7.10 (d, J=9Hz, ArH) and 7.41 (s, PhH). Trans Isomer: IR (CHCI3) 1718, 1623 and 1577 cm1. MS (m/e) 420 (M+), 404, 335, 329, 316, 257 and 91. PMR #TMS 0.83 (m, terminal methyl), 1.26 (s, gem CDCI3 dimethyl), 2.0-2.8 (m), 3.3 (m), 3.4-4.0 (m), 5.13 (s, benzylic methylene), 6.9 (m, ArH), 7.07 (d, J=8Hz, ArH) and 7.41 (s, PhH). In like manner, the cis- and trans-isomers of 8-oxabicyclo [5.1.0]-4-(2-benzyloxy-4-(1,1-dimethylheptyl) phenyl]-2-octanone are prepared from 6-(2-benzyloxy-4- (l,l-dimethylheptyl)phenyl]cyclohept-3-en-1-one. EXAMPLE 53 3- t 2-Benzyloxy-4- ( 1, l-dimethylheptyl ) phenyl3 - cis-5-hydroxycyclohexanone To a solution of 267 mg. (0.635 mmole) of the cisisomer of 7-oxabicyclo[4.1.0]-4-[2-benzyloxy-4-(1,1dimethylheptyl)phenyl]-2-heptanone in 20 ml. of 10% aqueous tetrahydrofuran was added 220 mg. of aluminum amalgam (prepared by washing I cm. strips of aluminum foil 15 seconds each in 2N sodium hydroxide, water, 0.5% mercuric chloride, water, 2N sodium hydroxide, water, 0.5% mercuric chloride, water, ethanol and ether). The reaction was stirred 3 hours at 250 C. and then filtered through diatomaceous earth. The filtrate was evaporated. on a rotovapor and the residue dissolVed 1=1 ether, dried over magnesium sulfate and evaporated. The residue was purified vie preparative layer chromatcgraphy on two 20 cm. x 20 cm. x 2mm. silica gel plates eluted with ether to yield 156 mg. (58%) of the title compound as an oil. IR (CHCI3) 3597, 3546, 1718, 1612 and 1577 cm 1. MS (m/e) 422, 404, 337, 331, 319, 313 and 310. PMR #TMS 0.81 (m, terminal methyl), 1.22 (s, gem CDCI3 dimethyl), 3.2 (m, benzylic methine), 3.95 (m, carbinol methine), 5.02 (s, benzylic methylene), 6.9 (m, ArH), 7.03 (d, J-8Hz, ArH) and i,38 (s, PhH). EXAMPLE 54 3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] trans-5-hydroxycyclohexanone Using the procedure of Example 53, 1.47 g. (3.5 mmole) of the trans isomer of 7-oxabicyclo[4.1.0]- 4-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-2-heptanone gave 1.25 g. (84%) of the title compound. m.p. 950 C. (pentane) IR (CHCI3) 3636, 3448, 1724, 1626 and 1587 cm-1. MS (m/e) 422 (M+), 404, 337, 331, 319, 313 and 91. TMS PMR # CDCI3 0.85 (m, terminal methyl), 1.25 (s, gem dimethyl), 2.15 (m), 2.3-2.8 (m), 3.9 (m, benzylic methine), 4.5 (m, carbinol methine), 5.12 (s, benzylic methylene), 6.9 (m, ArH), 7.08 (d, J=BHz, ArH) and 7.40 (bs, PhH). In like manner, reduction of the cis- and transisomers of a-oxabicyclo(5.1.o]-4-4-[2-benzyloxy-4-(1,1dimethylheptyl) phenyl] -2- octanone affords-the corresponding cis- and -trans 5-hydroxy derivatives. EXAMPLE 55 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl]trans-5-cyclohexan-1,5-diol, and the trans-3-cis-5 isomer Using the procedure of Example 2, 629 mg. (1.49 mmole) of 3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]trans-5-hydroxycyclohexanone (Example 54) gave 237 mg. (38%) of the trans-3 cis-5 isomer and 385 mg. (61%) of the trans isomer of title compound. Cis-5 Isomer : HRMS (m/e) 424.3002 (M+, calc'd. for C28H40O3: 424.2927) TMS PMR # CDCI3 0.83 (m, terminal methyl), 1.25 (s, gem dimethyl), 4.25 (m, carbinol methine), 5.13 (5, benzylic methylene), 6.9 (m, ArH), 7.12 (d, J=8Hz) and 7.41 (m, PhH). Trans-5 isomer : HRMS (m/e) 424.2992 (M+, calo'd for C28H4003: 424.2927), 339, 231, 213 and 91. TMS PMR # CDCI3 0.83 (m, terminal methyl), 1.25 (s. gem dimethyl), 3.0-4.4 (m, 3H), 5.10 (s, benzylic methylene), 6.88 (d, J=2Hz, ArH), 6.88 dd, J=8 and 2Hz, ArH), 7.10 (d, J=8Hz, ArH) and 7.40 (m, PhH). EXAMPLE 56 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl]cis-5-cyclohexan-1,5-diol, and the cis-3-trans-5 Isomer Using the procedure of Example 2, 203 mg. (0.481 mmole) of 3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]cis-5-hydroxycyclohexanone (Example 54) was reduced to 25 mg. (12%) of the cis-3 trans-5 isomer of title compound and 132 mg. (65%) of the title compound. Cis-3-cis-5 Isomer: HEMS 424.2974 (M , calc'd. for C28z4003: 424.2927), 339, 298, 231, 213 and 91. The remaining compounds of Example 54 are reduced to corresponding cycloheptandiols in like manner. EXAMPLE 57 Cis-3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl] cis-5-cyclohexan-1,5-diol Using the procedure of Example c, 132 Dg. (0.311 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-cis-5-cyclohexan-1,5-diol was converted to 72 mg. (69%) of the title compound. m.p. 1280 C. (ether-pentane) HRMS (m/e) 334.2517 (M+, calc'd. for C21H3403: 334.2483), 298, 249, 231 and 213. TMS PMR # CDCI3 0.83 (t, terminal methyl), 1.24 (s, gem dimethyl), 2.94 (m, benzylic methine), 3.35, 3.11 (bs, OH), 3.47-3.97 (m, carbinol methines), 6.72 (m, ArH) and 7.00 (d, J=8Hz, ArH). EXAMPLE 58 Cis-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl) trans-5-cyclohexan-l, 5-diol Using the procedure of Example 6, 385 mg. (0.908 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl] trans-5-cyclohexan-l,5-diol gave 162 mg. (53%) of the title compound. m.p. 1700 C. (dichloromethane) HRMS (m/e) 334.2513 (M+, calc'd. for C21H3403: 334.2483), 298,. 249, 231 and 213. PMR (100 MHz, CDCI3, D6-DMSO) 4 0.81 (m, terminal methyl), 1.23 (s, gem dimethyl), 3.38 (m, benzylic methine), 3.9-403 (m, carbinol methines), 6.74 (m, ArH). and 7.00 (d, J=8Hz, ArH). EXAMPLE 59 Trans-3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl] cis-5-cyclohexan-l, 5-diol Using the procedure of example 6, 237 mg. (0.558 mmole) of trans-3- (2-benzyloxy-4- (1, 1-dimethylheptyl)- phenyl;]-cis-5-cyclohexan-1,5-diol gave 107 mg. (57%) of the title compound. m.p. 126-127 C. (ether-pentane) HRMS (m/e) 334.2503 (M+, calc'd. for C21H34O3 334.2483), 316, 298, 249 and 231. PMR (100 MHz, CDCI3, D6-DMSO) 6 0.83 (m, terminal dimethyl), 1.24 (5, gem dimethyl), 3.82 (m, benzylic methine), 4.29 (m,.carbinol methines), 6.88 (m, ArH) and 7.06 (d, J=8Hz, ArH). In like manner, the cycloheptandiols of Example 56 are debenzylated. EXAMPLE 60 Trans-3- (2, 4-Dibenzyloxyphenyl) 4-(2-propenyl)cyclohexanone Using the procedure of Example 1, 23 g. (62.3 mmole) of 2,4-dibenzyloxybromobenzene and 7.2 g. (53 mmole) of 4-(2-propenyl)-2-cyclohexanone gave 8.56 g. (38%) of the title compound. m.p. 104-106 C. (diisopropyl ether) HRMS (m/e) 426.2203 (M , calc'd. for C29H3003: 426.2187),- 335, 181 and 91. Analysis: Calc'd. for C29H30O3: C, 81.66; H, 7.09. Found: C, 81.53; H, 6.85. EXAMPLE 61 Trans-3-(2,4-Dibenzyloxyphenyl)-4 (2-propenyl) cyclohexane ethylene Ketal A mixture of 5.0 g. (11.73 mmole) of trans-3-(2,4- dibenzyloxyphenyl)-4-(2-propenyl)cyclohexanone, 6.5 ml. (117 mmole) of ethylene glycol and 223 mg. (1.17 mmole) of p-toluenesulfonio acid in 50 ml. of benzene was heated at reflux for 1.5 hours. Water was removed via a soxhlet extractor filled with molecular sieves. The reaction was cooled and added to 500 ml. saturated sodium bicarbonate and 300 ml. ether. The ether phase was separated, dried over magnesium sulfate and evaporated. Trituration with diisopropyl ether-hexane gave 5.31 g. (96%) of the title compound. m.p. 112-113 C. HRMS (m/e) 470.2520 (M , calc'd. for C31H3404: 470.2448), 387, 379, 303, 181 and 91. Analysis : Calc'd. for C31H34O4: C, 79.12; H, 7.28. Found : C, 79.13; H, 7.02. EXAMPLE 62 Trans-3-(2,4-Dibenzyloxyphenyl)-4 (3-hydroxypropyl)cyclohexanone ethylene Ketal Using the procedure of Example 5, 5.00 g. (10.6 mmole) of trans-3-(2,4-dibenzyloxyphenyl)-4-(2-propanyl)cyclohexanone ethylene ketal afforded a quantitative yield of the title compound as an oil. The product was used in the procedure of Example 80 without purification. EXAMPLE 63 Trans-3-(2,4-Dibenzyloxyphenyl)-4 (3-hydroxypropyl)cyclohexanone A mixture of 5.17 g. (10.6 mmole) of trans-3-(2,4dibenzyloxyphenyl)-4-(3-hydroxypropyl)cyclohexanone ethylene ketal, 50 ml. 1N hydrochloric acid and 100 ml. tetrahydrofuran was heated at reflux or one hour. The reaction was cooled, partially evaporated on a rotovapor and the residue diluted with 300 ml. saturated sodium chloride-300 ml. ether. The ether extract was washed with 300 ml. saturated sodium bicarbonate, dried over magnesium sulfate and evaporated. The residue was crystallized from diisopropyl ether to yield 4.32 g. (92%) of the title compound. m.p. 110-117 C. Analysis : Calc'd. for C29H32O4: C, 78.35; H, 7.26. Found: C, 78.17; H, 7.15 EXAMPLE 66 Trans-3-(2,4-Dihydroxyphenyl)-4 (3-hydroxypropyl)cyclohexanone Following the procedure of Example 5, 3.9 g. (8.78 mmole) of trans-3-(2,4-dibenzyloxyphenyl)-4- (3-hydroxyphenyl)cyclohexanone provided 2.12 g. (91%) of the title compound as an oil. HRMS (m/e) 264.1345 (M+, calc'd. for C15H2004: 264.1356), 178, 163, 161, 155, 136 and 123. EXAMPLE 65 3,4-Dihydro-2-methoxy-7-hydroxy-2,4 propano-2H-1-benzopyran-9-propanol A solution of 1.5 g. (5.68 mmole) of trans-3 (2, 4-dihydroxyphenyl) -4- (3-hydroxypropyl) cyclohexanone in 40 ml. methanol, 6 ml. trimethylorthoformate and 7 drops of concentrated sulfuric acid was stirred at 00 C. for 45 minutes. The reaction was quenched by the addition of excess solid sodium bicarbonate and then evaporated on a rotovapor. The residue was diluted with 300 ml. saturated sodium bicarbonare-300 ml. ether. The ether extract was dried over magnesium sulfate and evaporated. The crude product was purified via column chromatography on 150 g. of silica gel eluted in 15 ml. fractions with ether to yield 1.29 g. (82%) of the title compound as an oil. PMR (CDCI3 + + D6-DMSO) 6 1.88 (m), 2.85 (m), 3.35 (s, methoxy), 3.45 (m, methylene), 6.22 (d, J=2Hz, ArH), 6.22 (dd, J=8 # 2Hz, ArH) and 6.75 (d, J=8Hz, ArH). HRMS (m/e) 278.1514 (M+, calc'd. for C16H22O4: 278.1512), 246, 192, 177 and 161. EXAMPLE 66 d-3,4-Dihydro-2-methoxy-7- [ (2-octyl)oxy] - 2,4-propano-2H-1-benzopyran-9-propanol A mixture of 700 mg. (2.52 mmole) of 3,4-dihydro 2-methoxy-7-hydroxy-2, 4-propano-2H-1-benzopyran-9-propanol 786 mg. (3.78 mmole) of 1-2-octylmethanesulfonate and 1.38 g. (10 mmole) of anhydrous potassium carbonate in S ml. of dimethylformamide was heated at 800 C. for 8 hours and then stirred at room temperature for 10 hours. The reaction mixture was added to 300 ml. saturated sodium chloride-300 ml. etcher. The ether extract was dried over magnesium sulfate and evaporated. The crude product was purified via column chromatography on 100 g. of silica gel eluted ifl 10 ml. fractions with ether to yield 711 mg. (72%) of the title compound as an oil. PMR (CDC13) 6 5 0.88 (n, terminal methyl), 1.28 (d, J=6Hz, methyl), 2.95 (m), 3.40 (s, methoxy), 3.70 (m, methylene), 4.22 (m, methine), 6.35 (m, ArH) and 6.82 (d, J=8Hz, ArH). HRMS (m/e) 390.2769 (M+, calc1d. for C24H3804: 390.2760), 304, 289, 273, 192, 191, 177 and 161. [a]D20 C. = +3.17 (c=1.29 methanol) EXP MSLp 67 d-Trans-3-[2-hydroxy-4-(2-octyloxy)phenyl)-4 (3-hydroxypropyl)cyclohexanone A mixture of 711 mg. (1.82 mmole) of d-3,4-dihydro2-methoxy-7-[(2-octyl)oxyl-2,4-propano-2H-1-benzo pyran-9-propanol, 25 ml. tetrahydrofuran and 15 ml. 1N hydrochloric acid was heated 1.5 hours at reflux. The reaction was cooled and diluted with 200 ml. saturated sodium chloride-200 ml. ether. The ether extract was washed with 200 ml. saturated sodium bicarbonate, dried over magnesium sulfate and evaporated to give a quantitative yield of the title compound as an oil. HRMS (m/e) 376.2592 (M , calc'd. for C23H3604: 376.2604), 290, 275, 264, 179, 178, 177, 164, 163 and 161. EXAMPLE 68 d-Cis-3-[2-hydroxy-4-(2-octyloxy)phenyl]-trans-4 (3-Hydroxypropyl)cyclohexanol and the trans-3, cis-4 isomer Using the procedure of Example 2, 684 mg. (1.82 mmole) of d-trans-3-[2-hydroxy-4-(2-octyloxy)phenyl]-4-(3hydroxypropyl)cyclohexanone yielded in order of elution with 50% ether-dichloromethane, 420 mg. (61%) of the title compound and 75 mg. (11%) of the trans-3, cis-4 isomer as oils. Cis-3, trans-4 [a]D20 C. =+4.26 (a=1.01, methanol) HRMS (m/e) 378.2762 (M+, calc'd. for C23H3804: 378.2760), 266, 248, 147 and 123. Trans-3, cis-4 HRMS (m/e) 378.2789 (M+, caic'd. for C23;43804: 378.2760), 266, 248 and 123. EXAMPLE 69 1-3,4-Dihydro-2-methoxy-7-[(2-octyl)oxy] 2,4-propano-2H-1-benzopyran-9-propanol Using the procedure of Example 66, 700 mg. (2.52 mmole) of 3, 4-dihydro-2-methoxy-7-hydroxy-2, 4-ptopano- 2H-1-benzopyran-9-propanol and 786 mg. (3.78 mmole) of d-2-octylmethanesulfonate gave 742 mg. (75%) of the title compound as an oil. PMR (CDCI3) 6 0.88 (m, methyl), 1.29 (d, J=6Hz, methyl), 2.92 (m, methine), 3,38 (s, methoxy), 3.7 (m, methylene), 4.25 (m, methine), 6.3 (m, ArH) and 6.80 (d, J=8Hz, ArH). [a]D20 = -1.76 (c=1.33, methanol) HRMS (m,/e) 390.2763 (M+, calc'd. for C24H3804: 390.2769), 304, 289, 278, 273, 246, 192, 191, 177 and 175. EXAMPLE 70 1-Trans-3-[2-hydroxy-4-(2-octyloxy)phenyl]-4 (3-hydroxyoropyl)cyclohexanone Using the procedure of Example 67 , 742 mg. (1.90 mmole) of 1-3,4-dihydro-2-methoxy-7-[(2-octyl)oxy]2,4-propano-2H-1-benzopyran-9-propanol gave a quantitative yield of title compound as an oil. HRMS (m/e) 376.2624 (M+, calc'd. for C23H3604: 376i2592), 264, 179, 178 and 177. EXAMPLE 71 1-Cis-3-[2-hydroxy-4-(2-octyloxy)phenyl]-trans-4 (3-hydroxypropyl)cyclohexanol and the trans-3,cis-4 isomer Using the procedure of Example 5 714 mg. (1.90 mmole) of 1-trans-3-[2-hydroxy-4-(2-octyloxy)phenyl]-4 (3-hydroxypropyl) cyclohexanone afforded 483 mg. (67%) of the title compound and 101 mg (14%) of five trans-3, cis-4 isomer as oils. Cis-3, trans-4 200 C. @@ @@ @@@@@@ @@@@@@@ HRMS (m/e) 378.2775 (M+, calc'd. for C23H3804: 378.2760), 266, 249, 248, 147 and 123. Trans-3, cis-4 HRMS (m/e) 378.2767 (M+, calc'd. for C23H3804: 378.2760), 266, 248, 189, 149, 147 and 123. EXAMPLE 72 Trans-4-(2-Propenyl)-3-[2-(tetrahydropyranyl-2-oxy)¯ 4-(1,1-dimethyl)-cis-2-heptenyl)phenyl)cyclohexanone To a 00C solution of 2.0 g. (6.62 inmole) of 1,1dimethyl-1-[3-(tetrahydropyranyl-z-oxy)phenyl]-cis-2heptene and 844 mg. (7.28 mmole) of tetramethylethylene diamine in 10 ml. of ether was slowly added 3.17 ml. (7.28 mmole) of m-butyllithium (in hexane). The resultant solution was stirred 5 minutes at OOC. and then refluxed for 70 minutes. The resultant was then cooled to -780C. To a 0 C. solution of 597 m. (7.28 mmole) of 1- hexyne in 10 ml. of tetrahydrofuran is slowly added 3.17 ml. (7.28 mmole) of m-butyllithium (in hexane). The resultant solution was stirred 10 minutes at OOC. and ten slowly added to a OOC. slurry of 1.38 g. (7.28 mmole) of cuprous iodide in 10 ml. of tetra- hydroeuran. The resultant yellow slurry was stirred 30 minutes at OOC. and then slowly added to the above prepared -78 C. solution of aryl lithium reagent. The resultant yellow mixture was stirred 10 minutes at -78 C. and then 900 mg. (6.62 mmole) of 4-(2-propenyl)- cyclohex-2-en-l-one is added dropwise. Stirring was continued for 10 minutes and then the reaction was placed in a -40 C. cooling bath and allowed to warm to -200C. over 20 minutes. The reaction was quenched by addition to 200 ml. of cold saturated ammonium chloride brought to pH 10 with saturated ammonium hydroxide. The quenched reaction mixture was extracted with 300 ml. of ether. The ether extract was dried over magnesium sulfate and evaporated to an oil which was purified via column chromatography on 200 g. of silica gel eluted in 15 ml. fractions wit 20% etherhexane to yield from fractions 40-63, 2.36 g. (82%) of the title compound as an oil. EXAMPLE 72 (Cont.) IR (CHCl3) 1709, 1641, 1610 and 1571 cm-1. HRMS (m/e) 354.2569 (P+. -C5H8O: Calcd, for C24H32O2: 354.2550), 272, 271, 161, 137 and 85 (100%). PMR (CDCl3) 0.69 (m, terminal CH3), 1.41 (s, gem dimethyl), 0.8-4.2 (series of m), 4.7-5.6 (m, olefinic H and THP methine), 5.62 (d, J=12Hz, vinyl H) and 6.7-7.3 (m, ArH). EXAMPLE 73 Trans-4-(2-Propenyl)-cis-3-[2-(tetrahydropyranyl-2 oxy)-4-(1,1-dimethyl-cis-2-heptenyl)phenyl] cyclohexanol and the cis-4,trans-3 isomer To a -78 C. solution of 20.0 g. (45.7 mmole) of trans-4-(2-propenyl)-3-[2-(tetrahydropyranyl-2-oxy)-4 (1,1-dimethyl-cis-2-heptenyl)phenyl]cyclohexanone in 200 ml. of methanol was added in one portion 5.20 g. (137 mmole) of sodium borohydride. The reaction was stirred overnight at -78 C. and then allowed to warm to 0 C. The reaction was quenched with 10 ml. saturated sodium chloride and then concentrated on a rotovapor. The resicue was diluted with 500 ml. saturated sodium chlorine and 500 ml. ether. The ether extract was washed once with 250 ml. saturated sodium bicarbonate, dried over magnesium sulfate and evaporated to an oil. The crude oil was purified via column chromatography on 1 kg. of silica gel eluted with 30% ether-hexane to yield in order of elution 2.20 g. (11%) of the cis-4,trans-3 isomer, 0.74 g. (4%) of mixture and 17.0 g. (85%) of the title compound as oils. Title Compound: IR (CHC13) 3593, 3464, 1640, 1610 and 1571 cm 1. HRMS (m/e) 356.2709 (P. -C5H80, Calcd. for C24H3602: 356.2706), 297, 273, 255, 124 and 85 (100%). PMR (CDC13) 6 O. 70 (m, terminal CH3), 1.42 (s, gem dimethyl), 2.8 (bm, benzylic methine), 3.4 4.1 (m, carbinol methine and OCH2), 4.6- 5.5 (m, vinyl H and THP methine), 5.60 (d, J-11 Hz, vinyl H) and 6.8-7.2 (m, ArH). EXAMPLE 74 Trans-4- (3-Hydroxypropyl) -cis-3- [2- (tetrahydro pyranyl-2-oxy)-4-(1,1-dimethyl-cis-2-heptenyl) phenyl] cyclohexanol To a -50C. solution of 13.3 g. (0.0302 mole) of trans-4-(2-prope4nyl)-cis-3-[2-(tetrahydropyranyl-2 oxy) -4- (l,l-dimethyl-cis-2-heptenyl) phenyi' cyciohexanoi in 100 ml. of tetrahydrofuran was slowly added 35.1 ml. (0.0351 mole) of boran-tetrahydrofuran (1M in tetra- hydrofuran), with stirring. After 30 minutes another 50 ml. of tetrahydrofuran was added and the reaction stirred 30 minutes longer, then quenched by addition of 40 ml. (0.12 mole) of 3N sodium hydroxide and oxidized by addition of 10 ml. (0.112 mole) of 30% hydrogen peroxide. After stirring 20 minutes the reaction was added to 500 ml. saturated sodium chloride - 500 ml. ether. The aqueous phase was extracted with another 250 ml. portion of ether and the combined ether extract dried over magnesium sulfate and evaporated to an oil. The crude oil was purified via column chromatography on 1 kg. of silica gel eluted with 80% etherhexane to 3% methanol-ether to yield in order of elution 600 mg. (5%) of unreacted starting material, 7.45 g. (548) of the title compound as an oil, 1.32 g. (12%) of trans-4- (3-hydroxypropyl) -cis-3- [2-hydroxy-4- (1, l-di methyl-c is- 2-heptenyl) phenyl] cyclohexanol (phenolic product) and 1.78 g. (13%) of trans-4-(3-hydroxy propyl)-cis-3- (2- (tetrahydropyranyl-2-oxy) -4- (1,1- dimethyl-3-hydroxyheptyl)phenyl)cyclohexanol $(Tricl THP). Example 74 (Cont.) Title Compound: HRMS (m/e) 374.2831 (P. -C5H80, Calod. for C24H38O3: 374.2811), 356, 242, 151 and 85. PMR (CDCl)3 # 0.72 (m, terminal CH3), 1.40 (s, gem dimethyl), 2.8 (m, benzylic methine), 3,47 (m, CH2OH), 3.2-4.2 (m, carbinol methine and -CH20-), 4.9-5.5 (vinyl H and THP methine), 5.62 (d, J=llHz, vinyl H) and 6.9-7.2 (m, ArH). Phenotic Product: HRMS (m/e) 374.2839 (M+., Calcd. for C24H38O3: 374.2811), 356, 341, 299, 273 and 270. Triol-THP: HRMS (m/e) 392.2949 (P. -C5H80, Calcd. for C24H40O4: 392.2916), 374, 292, 274, 165 and 85 (100%). EXAMPLE .75 Trans-4-(3-d-andeloyloxy)-cis-3-[2-hydroxy-4 (l,l-dimethyl-cis-2-heptenyl) phenyl] -l-d-mandeloyloxy- cyclohexane A mixture of 6.00 g. (13.1 mmole) of trans-4-(3 hydroxypropyl)-cis-3-12-(tetrahydropyranyl-2-oxy)-4- (1,1-dimethyl-cis-2-heptenyl)phenyl]cyclohexanol, 9.96 g. (65.5 mmole) d-mandelic acid and 498 mg. 2.62 mmole) p-toluenesulfonic acid monohydrate in 250 ml. of benzene was heated at reflux. Water was removed via a 3A molecular sieve filled soxhlet extractor. The reaction was heated at reflux for 160 minutes with additional portions of p-toluenesulfonic acid monohydrate added at d0, 80 and 120 minutes. The reaction -was cooled and added to 500 ml. saturated sodium bicarbonate - 500 ml. ether. The aqueous phase was ex-, tracted with a second 250 ml. portion of ether and the combined ether extract dried over magnesium sulfate and evaporated to an oil. The crude product was purified via column chromatography on 800 g. of silica gel eluted with 55% ether-hexane to yield order of elution 2.25 g. (27%) of diastereomer A of the title compound, 2.0 g. (24%) of a mixture and 4.0 g. (48%) of slightly impure diastereomer B of the title compound as oils. Diastereomer A: 200ta1 CH3OH = + 31.620 (C=1.85) D PMR (CDC13) 6 0.68 (m, terminal CH3), 1.37 (s, gem dimethyl), 3.4 (bd, J=6Hz, OH), 3.93 (bt, J= 6Hz, -CH2O-), 4.75 (m, OH), 5.02 (m, CHOH), 5.0-5.7 (m, vinyl H), 6.6-6.9 (m, ArH), 7.23 and 7.26 (s, PhH). EXAMPLE 76 (-)-Trans-4-(3-hydroxypropyl)-cis-3-[2-hydroxy-4 (1,1-dimethyl-cis-2-heptenyl)phenyl]cyclohexanol A mixture of 3.10 g. (4.82 mmole) of diastereomer A of trans-4-(3-d-andeloyloxy)-cis-3-[2-hydroxy-4 (1,1-dimethyl-cis-2-heptanyl)phenyl)-1-d-mandeloyloxycyclohexane, 5.32 g. (38.6 mmole) potassium carbonate, 40 ml. methanol, 40 ml. tetrahydrofuran and 10 ml. water was stirred at 250C. for 24 hours. The reaction was evaporated on a rotovapor and the residue dissolved in 250 ml. ether - 250 ml. saturated sodium chloride. The aqueous phase was extracted with two additional 150 ml. - portions of ether, the combined ether extract dried over magnesium sulfate and evaporated to an oil. The crude product was purified via column chromatography cn 150 g. of silica gel eluted with ether to yield 1.3 g. (72î) of the title compound. MP: 95-97 C. (Diisopropyl ether-hexane) 20 [a]DCH3OH = -56.32 HRMS (m/e) 374.2819 (M+. , Calcd. for C24H3803: 374.2811), 356, 213, 187, 161, 147, 124, 121, and 93. PMR (250 mHz, CDCI3) 6 0.73 (m, terminal methyl), 1.39 (s, gem dimethyl), 2.03 (m, CH2-vinylic), 2.72 (m, benzylic methine), 3.47 cm: CH2OH), 3.74 (m, CHOH), 5.07 (bs, OH), 5.22 and 5.27 (dt, J=lI.51 and 7.31 Hz, vinyl S), 5.61 (dt, J=11.51 and 1.6 Hz, vinyl H), 6.73 (d, J=1.64 Hz, ArH), 6.91 (dd, J=8.22 and 1.82 Hz, ArH) and 7.02 (d, J=8.04 Hz, ArH). EXAMPLE 77 (-)-Trans-4-(3-hydroxypropyl)-cis-3-[2-hydroxy-4 (1,1-dimethylheptyl)phenyl)cyclohexanol A mixture of 50.0 mg. (0.134 mmole) of (-)-trar.s- 4- (3-hydroxypropyl) -cis-3- (2-hydroxy-4- (1, 1-dimethyl- cis-2-heptenyl)phenyl]cyclohexanol and 50 mg. of 10% palladium on carbon in 5 ml. of dry tetrahydrofuran was stirred under one atmosphere of hydrogen for 30 minutes. The reaction was filtered through diatomaceous earth with tetrahydrofuran and the filtrate evaporated to yield 47.9 mg. (95%) of the title compound as an oil. 20 [&alpha;]DCH3OH = -36.12 . EXAMPLE 78 Trans-3,4,trans-4,5-3-[2-benzyloxy-4-(1,1-dimethyl heptyl) phenyl] -S-methyl-4- (2-propenyl) cyclohexanone Using the procedure of Example 1, 7.5 g. (50 mmole) of trans-5-methyl-4-(2-propenyl)cyclobex-2-en-1-one and 24.3 g. (62.5 mmole) of l-benzyloxy-2-bromo-5-(1,l-di- methylheptyl)benzene gave 13.0 g. (57%) of the title compound as an oil. IR (CHCI3) 1709, 1639, 1609 and 1568 cm 1 HRMS (m/e) 460.3353 (M+. , Calcd. for C32H4402: 460.3330), 375, 370, 369 and 91 (100%). PMR (CDCl3) 6 0.82 (m, terminal CH3), 1.26 (s, gem, dimethyl), 4.5-5.1 (m,-vinyl H), 5.00 (s, benzylmethylene), 5.3-5.8 (vinyl H), 6.6-7.1 (m, ArH) and 7.25 (bs, PhH). In like manner, trans-3,4-trans-4,5-3-[2-benzyloxy- 4-(1,l- imethylheptyl)phenyl]-5-methyl-4-(2-propenyl)- cycloheptanone is prepared from trans-5-methyl-4-(2propenyl)cyclohept-2-en-1-one. EXAMPLE 79 c -3-t2-benzyloxy-4-(1,l-dimethylheptyl)phenylJ-cis-S- methyl-trans-4-(2-propenyl)cyclohexanol Using the procedure of Example 2, 6.0 g. (13.0 mmole) of trans-3,4-trans, 4,5-3-[2-benzyloxy-4-(1,1dimethylheptyl)phenyl]-5-methyl-4-(2-propenyl)cyclohexanone gave 1.1 g. (18%) of the cis-4,trans-3,trans-5 isomer of the title compound, 1.077 g. (17%) of a mix ture and 2.79 (46%) of the title compound as an oil. Cis-4,Trans-3,Trans-5 Isomer: UP,MS (m/e) 462.3501 (M+. , Calcd. for C32H46O2: 362.3486), 377, 269, 227 and 91 (1004). PMR (CDCl3) 6 0.82 (m, terminal methyl), 0.95 (d, J=6Hz, methyl) 1.23 (s, gem dimethyl), 3.5 (m, benzylic methine), 4.13 (m, carbinol methine), 4.6-5.0 (m, vinyl H), 5.05 (s, benzylic methylene), 5.2-6.1 (m, vinyl H), 6,85 (m, ArH), 7.05 (d, J=8Bz, ArH) and 7.38 (bs, PhH). Title Compound: IR (CHCI3) 3596, 3463, 1639, -1609 and 1570 cm-1 HRMS (m/e) 462.3499 (M+. , Calcd. for C32H4602: 462.3501), 377, 353, 269, 227 and 91 (100%). PMR (CDC13) 6 0.83, (m, terminal CH3), 1.25 (s, gem dimethyl), 3.2 (m, benzylic methine), 3.62 (bm, carbinol methine), 4.5-5.0 (m, vinyl H), 5.02 (s, benzylic methylene), 5.3 6.1 (m, vinyl H), 6.82 (m, ArH), 7.00 (d, J= 8Hz, ArH) and 7.35 (bs, PhH). Following the above procedure trans-3,4-trans-4,53-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-5-methyltrans-4-(2-propenyl)cycloheptanone is prepared from the correspondingly substituted cyclohept-2-en-1-one. EXAMPLE 80 Trans-3,4-Trans,4,5-3-[2-benzyloxy-4-(1,1-dimethyl heptyl)phenyl)-5-methyl-4-(2-propenyl)cyclo hexanone ethylene ketal A mixture of 7.0 g. (15.2 mmole) of trans-3,4- trans,4,5-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]5-methyl-4-(2-propenyl)cyclohexanone, 8.47 ml. (152 mmole) of ethylene glycol and 289 mg. (1.52 mnole) of ±-toluenesulfonic acid monohydrate was heated at reflux for 2.5 hours. Water was removed via a soxhlet extractor filled with 3A sieves. The reaction was cooled and added to 250 ml. saturated sodium bicarbonate - 250 ml. ether. The ether extract was dried over masnes- sulfate and evaporated to an oil. The crude product was purified via column chromatography on 300 g. of silica gel eluted with 20% ether-hexane to yield 5.2 5. (68%) of the title compound as an oil. IR (CHC13) 1638, 1608 and 1569 cm-1. TMS (m/e) 504.3579 (M+. , Calcd. for C34H4803: 504.3591), 419, 413, 407 and 91 (100%). PMR (CDC13) 6 0.82 (m, terminal methyl), 0.99 (d, J=6Hz, CH3), 1.25 (s, gem dimethyl), 3.4 (m, benzylic methine), 3.90 (s, ethylene ketal), 4.4-5.0 (m, vinyl H), 5.03 (s, benzylic methylene), 5.3-6.2 (m, vinyl H), 6.80 (m, ArH), 7.00 (d, J=8Hz, ArH) and 7.35 (bs, PhH). The ethylene ketal of trans-3,4-trans-4,5-3-[2- benzyloxy040(1,1-dimethylheptyl)phenyl]-5-methyl-4-(2propenyl)cycloheptanone is prepared in like manner from the corresponding cycloheptanone. EXAMPLE 81 Cis-3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl) cis-5-methyloyclohexanol To a OOC. solution of 900 mg. (1.95 mmole) of cis3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-cis-5methyl-trans-4-(2-propenyl)cyclohexanol in 2 ml. of ether was added 5.1 ml. (11.7 mmole) of n-butyllithium (in hexane). The reaction was stirred 10 hours at 250C. and then added to 200 ml. ether - 200 ml. saturated ammonium chloride. The ether extract was dried over magnesium sulfate and evaporated to an oil. This oil was crystallized in hexane to yield 495 mg. (68%) of the title compound. MP 149-1500C. (hexane) IR (CHC13) 3455, 3253, 1643, 1617 and 1583 cm-1. HRMS (m/e) 372.3050 (M. , Calcd. for C25H4002: - 372.3018), 312, 288, 287 (100%), 272, 269, 227, 187s 161, 147 and 135. Analysis: Analysis Calcd. For C25H002: C, 80.59; H, 10.82 Found : C, 80.35; H, 10.81 Debenzylation of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl) phenyl] -cis-S-methyl-trans-4- (2-propenyl) cycloheptanol is carried out in like manner. EXAMPLE 82 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] trans-4-(3-hydroxypropyl)-cis-5-methylcyclohexanol Using the procedure of Example 5, 900 mg. (1.95 mmole) of cis-3- [2-benzyloxy-4-(1, l-dimethylheptyl) phenyl] -cis-5-methyl-trans-4- (2-propenyl) cyclohexanol was converted in quantitative yield to the title compound, an oil. HRMS (m/e) 480.3574 (M+. , Calcd. for C32H4803: 480.3591), 462, 395, 377, 287 and 91 (100%). By means of this procedure, cis-3-[2-enzyloxy-4- (1,1-dimethylbeptyl)phenyl]-cis-5-methyl-trans-4-(2 propenyl)cycloheptanol is converted to the corresponding 3-hydroxypropyl derivative. EXAMPLE 83 Cis-3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl] trans-4-(3-hydroxypropyl)-cis-5-methylcyclohexanol Using the procedure of Example 6, 936 mg. (1.95 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)-cis-5-methylcyclohexanol afforded 602 mg. (79%) of the title compound. MP 159-1600C. (diisopropyl ether - ethyl acetate) IR (KBr) 3533, 3367, 3211, 1617 and 1585 cur 1. HRMS (m/e) 390.3100 (M. , Calcd. for C25H4203, 390.3123), 372, 304, 288, 287, 272, 257, 227, 219 and 187. Analysis: Anal. Calcd. For C25H4203: C, 76;87; H, 10.84. Found : C, 76.60; H, 10.66. Similarly, cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl) phenyl] -trans-4- (3-hydroxypropyl) -cis-5-methylcycloheptanol is debenzylated to the corresponding phenol. EXAMPLE 8A Trans-3,4,Trans-4,5-3-[2-benzyloxy-4-(1,1-dimethylheptyl) phenyl]-4-(2-hydroxypropyl)-5-methylcylohexanone ethylene ketal To a 250C. mixture of 3.28 g. (10.3 znmole) of mercuric acetate in 50 ml. of 50% aqueous tetrahydrofuran was added 5.2 g. (10.3 mmole) of trans-3,4,trans 4, 5-3- [-2-benzyloxy-4- (1, l-dimethylheptyl) phenyll -5- methyl-4- (2-propenyl) cyclohexanone ethylene ketal in 25 ml. tetrahydrofuran. Another 25 ml. of water was added to aid solution and stirring. Additional 1.5 g. (4.7 mmole) portions of mercuric acetate were added after 2 hours and 24 hours. The reaction was stirred a total of 64 hours at 250C. and then reduced by addition of 20 ml. 3N sodium hydroxide and 20 ml. o 0.5A sodium borohydride in 3N sodium hydroxide. The reaction was stirred 30 minutes longer and then added to 250 ml. ether - 300 ml. saturated sodium chloride. The ether extract was dried over magnesium sulfate and evaporated to an oil. The crude product was purified via column chromatography on 300 g. of silica gel eluted with 50% ether-hexane to give 1.5 g. (30%) of the title compound as an oil. HRMS (m/e) 522.3712 (M+, Calod. for C34H50O4: 522.3696), 431, 407, 372, 113 and 91 (100%). PMR (CDC13) 6 0.75 (m, terminal methyl), 0.92 (d, J=6Hz, C-S methyl), 1.24 (5, gem dimethyl), 3.35 (bm, carbinol and benzylic methines), 3.90 (bs, ethylene ketal), 5.03 (s, benzylic methylene) and 6.6-7.5 (m, ArH). Trans-3,4-trans-4,-3[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl-4-(2-hydroxypropyl)-5-methylcycloheptanone ethylene ketal is also prepared via this procedure from the corresponding 4-(2-propenyl)cycloheptanone ethylene ketal. EXAMPLE 85. Trans-3,4,Trans-4,5-3-[2-Benzyloxy-4-(1,1-dimethyl heptyl)phenykl]-5-methyl-4-(2-oxopropyl)cyclo hexanone ethylene ketal To a 250C. mixture of 1.5 g. (2.87 mmole) of trans3,4,trans-4,5-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(2-hydroxypropyl)-5-methylcyclohexanone ethylene ketal, and 2.35 g. (28.7 minole) of sodium acetate in 20 ml. of dichloromethane was added 1.93 g. (9 mmole) of pyridinium chlorochromate. The reaction mixture was stirred 3 hours at 250C. and then added to 250 ml. 1N NaOH-250 ml. ether. The organic extract was dried over magnesium sulfate and evaporated to give a quantitative yield of the title compound as an oil. PMR (CDCI3) 6 0.85 (m, methyls), 1.23 (s, gem dimethyl), 1.80 (bs, CH3CO-), 2.23 (bs, -CH2CO-), 3.3 (m, benzylic methine), 3.93 (s, ethylene ketal), 5.05 (s, benzylic methylene) and 6.7-7.6 (m, ArH). In like manner, oxidation of trans-3,4-trans-4,5- 3-(2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(2hydroxypropyl)cycloheptanone ethylene ketal affords the corresponding 4-(2-oxopropyl)cycloheptanone ethylene ketal. EXAMPLE 86 Trans-3,4-Trans-4,5-3-[2-Benzyloxy-4-(1,1-dimethyl heptyl)phenyl]-5-methyl-4-(2-methyl-2-propenyl) cyclohexanone ethylene ketal To a 150C. mixture of 5.74 mmole of triphenyl phosphoniumethylide in 6 ml. of dimethyl sulfoxide was added a solution of 1.5 g (2.87 mmole) of trans-3,4-trans-4,3 3- [2-benzyloxy-4- (1, l-dimetnyl heptyl) phenyl] -5-methyl-4- (2-oxopropyl)cyclohexanone ethylene ketal in a 6 ml. of tetrahydrofuran and the reaction stirred 1.5 hours at 15-250C. It was then added to 200 ml. saturated sodium chloride - 200 ml. ether. The ether extract was washed once with 200 ml. saturated sodium chloride, dried over magnesium sulfate and evaporated to ive an oil. Purification via column chromatography on 50 C. of silica gel eluted with 20% ether-hexane gave 1.17 g. (79%) of the title compound as an oil. HR25S (m/e) 518.3706 (M+. , Calcd. for C35H5003: 518.3747), 462, 427, 407, 372, 371, 285 and 91 (100 PMR (CDCI3) 6 1.25 (s, gem dimethyl), 1.48 (bs, vinyl methyl), 3.3 (m, benzylic methine), - 3.89 (s, ethylene ketal), 4.40 (m, vinyl H), 5.02 (5, benzylic methylene), 6.85 (m, ArH), 7.10 (d, J=8Hz, ArH) and 7.4 (m, PhH). Trans-3,4-trans-4,5-3-[2-benzyloxy-4-(1,1-dimethyl heptyl) phenyl) -5-methyl-4- (2-oxopropyl) cycloheptanone ethylene ketal is converted in like manner to the corresponding 4- (2-methyl-2-propenyl) cycloheptanone ethylene ketal. EXAMPLE 87 Trans-3,4-trans-4,5-3-[2-Benzyloxy-4-(1,1-dimethyl heptyl)phenyl]-S-methyl-4-(2-methyl-2-propenyl)- cyclohexanone A mixture of 1.1 g. (2.12 mmole) of the ethylene petal of the title compound, 20 ml. tetrahydrofuran and 20 ml. 1N hydrochloric acid was heated at reflux for 5 hours and stirred at 25 C. for 16 hours. The reaction was added to 250 ml. saturated sodium chloride - 250 ml. ether. The ether extract was washed with 250 ml. saturated sodium bicarbonate, dried over magnesium sulfate and evaporated to give a quantitative yield of the title compound as an oil. FIRMS (m/e) 474.3524 (M.. , Calod. or C33H4602): 474.3486), 418, 383, 327, 273 and 91 (100%). Deketalization of trans-3,4-trans-4, 5-3-(2-benzyloxy- 4-(1,1-dimethylheptyl)phenyl]-5-methyl0-4-(2-methyl-2propenyl)cycloheptanone ethylene ketal is accomplished in like manner. EXAMPLE 88 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] cis-5-methyl-trans-4- (2-methyl-2-propenyl) cyclohexanol and its axial Isomer Using the procedure of Example 13, 1.00 g. (2.12 mmole) of trans-3, 4-trans-4, 5-3- t2-benzyloxy-4- (1,1- dimethylheptyl)phenyl)-cis-5-methyl-trans-4-(2-methyl2-propenyl)cyclohexanone gave 248 mg. (25%) of the trans-3,cis-4,trans-5 isomer of the title compound and 720 g. (71%) of the title compound as oils. Trans-3,cis-4, trans-S Isomer: HRMS (m/e) 476.3664 (M+. , Calcd. for C33H4802: 476.3642), 420, 335, 330, 329 (100%), 312, 311, and 283. Title Compound: HRMS (m/e) 476.3646 (M. , Calcd. for C33H4802: 476.3642), 420, 330, 329 and 91 (100%). Similarly trans-3, 4-trans-4, 5-3- t2-benzyloxy-4- (1,1- dimethylheptyl)phenyl]-cis-5-methyl-trans-4-(2-methyl2-propenyl)cycloheptanone is transformed to cis-3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]-cis-5-methyltrans-4-(2-methyl-2-propenyl)cycloheptanol and the corresponding axial derivative. EXAMPLE 89 Cis-3-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl] trans-4-(3-hydroxy-2-methylpropyl)-cis-5 methylcyclohexanol Using the procedure of Example 5, 710 mg. (1.49 mmole) of cis-3-[2-benzyloxy-4-(1,1-dimethylheptyl) phenyl]-cis-5-methyl-trans-4-[2-methyl-2-propenyl)cyclohexanol (compound of Example 107) gave 322 mg. (44%) of diastereomer A and 356 mg. (48%) of diastereomer B of title compound as oils. Diastereomer A: HRMS (m/e) 494.3769 (M. , Calcd. for C33H5003: 494.3747), 386, 301 and 91 (1009). Diastereomer B: HRMS (m/e) 494.3790 (M+. , Calod. for C33H50O3: 494.3747) and 91 (100%). In like manner, the remaining alkenyl derivatives of Example 88 ire hydrated to the corresponding alcohols. EXAMPLE 90 Cis-3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-trans 4- (3-hydroxy-2-methylpropyl) -cis-S-methylcyclohexanol Diastereomer A Using the procedure of Example 6, 320 mg. (0.648 mmole) of diastereomer A of cis-3-(2-benzyloxy-4-(1,1dimethylheptyl)phenyl]-trans-4-(3-hydroxy-2-methylpropyl)-cis-5-methylcyclohexanol (product of Example 108) provided 221 mg. (84%) of the title compound. MP 139-1410C. (diisopropyl ether-hexane) IR (CHC13) 3588, 3407, 1616 and 1579 cm-1. HRMS (m/e) 404.3247 (M. , Calcd. for C26H4403: 404.3279), 386, 301, 233, 187, 161 and 147 (100%). Analysis: Anal. Calcd. for C26H4403: C, 77.17; H, 10.96. Found : C, 77.41; H, 10.77. Diastereomer B Using the procedure of Example 6, 350 mg. (0.709 mmole) of diastereomer B of cis-3-[2-benzyloxy-4-(1,1- dimethylheptyl)phenyl]-trans-4-(3-hydroxy-2-methyl propyl) -cis-5-methylcyclohexanol (product of Example 108) gave 255 mg. (89%) of the title compound. MP 118-120 C. (diisopropyl ether-hexane). HRMS (m/e) 404.3237 (M+., Calod. for C26H44O3: 404.3279), 386, 318, 301 (100%), 233, 187, 167 and 147. EXAMPLE 90 vCont.) Analysis: Anal. Calcd. for C26H4403: C, 77.17; H, 10.96. Found : C, 77.40; H, 10.76. By means of this procedure, the remaining benzyl ethers of Example 89 are converted to the corresponding phenols. EXAMPLE 91 7-Oxabicyclo[4.1.0]-1-[2-benzyloxy-4-(1,1-dimethyl heptyl) phenyl]'-3-heptanone ethylene ketal To a 0 C. solution of 5.0 g. (11.2 mmole) of 3-(2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]cyclohex-3-en-1one ethylene ketal in 15 ml. of dichloromethane is added 1.26 g. (15 mmole) of sodium bicarbonate and 2.58 g. (15 mole) of m-chloroperbenzoic acid. The reaction is stirred overnight at OOC. and then filtered. The filtrate is dilated with 200 ml. of ether and washed with two 100 ml. portions of saturated sodium bicarbonate. The organic extract is dried over magnesium sulfate and evaporated to yield the title compound. EXAMPLE 92 3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-4 hydroxycyclohexanone ethylene ketal Following the procedure of Example 6, 7-oxabicyclo[4.1.0]-1-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-3-heptanone ethylene ketai is nyerogenated to give the title compound. Deketalization according to the procedure of Example 8 affords the corresponding ketone. Following the procedures of Examples 91 and 92, 3-[2- benzyloxy-4-(1,1-dimethylheptyl)phenyl]cyclohept-3-en-1 one is converted to 3-[2-hydroxy-4-(1,1-dimethylheptyl)- phenyl]-4-hydroxycycloheptanone. EXAMPLE 93 Cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-hydroxycyoclohexanol Sodium borohydride reduction of 3-[2-hydroxy-4- (1,1)-dimethylheptyl)phenyl]-4-hydroxycyclohexanone according to the procedure of Example 2 affords the title compound. Similarly, reduction of 3-[2-hydroxy-4-(1,1- dimethylheptyl)phenyl]-4-hydroxycycloheptanone affords the corresponding alcohol.

Claims: CLAIMS 1. A compound having the formula EMI151.1 wherein A when taken individually is hydrogen; B when taken individually is hydrogen, hydroxy, mandeloyloxy, alkanoyloxy having from one to five carbon atoms, amino or acetamido; A and B when taken together are oxo: R1 is hydrogen, alkanoyl having from one to five carbon atoms, P(O) (OH)2 and mono- and disodium and potassium salts thereof, -CO(CH2)2COOH and the sodium and potassium salts thereof, or -CO(CH2)pNR4R5: p is O or an integer from 1 to 4; each of R4 and R5, when taken individually, is hydrogen or alkyl having from one to four carbon atoms; or R4 and R5, when taken together with the nitrogen to which they are attached, are piperidino, pyrrolo, pyrrolidino, morpholino or N-alkylpiperazino having from one to four carbon atoms in the alkyl group; s is an integer of 1 or 2; Y is -CH(R2")CH(R2)- or -CH(R3)CH2-; R2" is hydrogen or methyl; R2 is hydroxy or X-substituted alkyl having from one to six carbon atoms; R3 is hydroxy, cyano or X-substituted alkyl having from one to three carbon atoms; X is -OR6, -NR6R7, -COOR7, -CONR7R8 or oxo; R6 is hydrogen, alkyl having from one to six carbon atoms, acetyl or mandeloyl; each of R7 and R8 is hydrogen or alkyl having from one to six carbon atoms; provided that when X is -NR6R7, -COOR7 or -CONR7R8, it is located on the terminal carbon atom of R2 or R3; and when R in -NR6R7 is acetyl, R7 is hydrogen; W is hydrogen, pyridyl or EMI152.1 wherein W1 is hydrogen, chloro or fluoro, provided that when W is hydrogen, Z is alkylene or oxaalkylene having from five to thirteen carbon atoms; and when W is other than hydrogen, Z is alkylene or oxaalkylene having from three to eight carbon atoms; or a pharmaceutically acceptable acid addition salt of those compounds which contain a basic group. 2. A compound as claimed in claim 1, in which, when A is hydrogen and B is other than hydrogen, B is in cis-relationship to the phenolic or substituted phenolic moiety at the 3-position, and in which R2 or R3 in Y is in trans-relationship to the said moiety. 3. A compound as.claimed in claim 1 or claim 2, in which A is hydrogen, B is hydroxy or acetamido, and R1 is hydrogen or benzyl. 4. A compound as claimed in any preceding claim in which either of R2 and R3 is hydroxyalkyl, alkoxyalkyl, carboalkoxyalkyl or dialkylaminoalkyl. 5. A compound as claimed in claim 4 in which R2 is 3-hydroxypropyl or 3-methoxypropyl. 6. A compound as claimed in claim 4 in which R3 is hydroxymethyl.. 7. A compound as claimed in any preceding claim in which Z-W is an alkyl group having 7 to 11 carbon atoms. 8. A compound as claimed in claim 7, in which Z-W is a l,l-dimethylheptyl group. 9. A compound having the formula EMI153.1 or EMI154.1 where R1 is hydrogen or benzyl and R6 is hydrogen or methyl, or a diastereomeric bis-d-mandelate thereof except when R6 is methyl. 10. A compound having the formula EMI154.2 11. A compound as claimed in any of claims 1 to 6, in which Z is oxaalkylene having 4 to 7 carbon atoms and W is a phenyl group. 12. A compound as claimed in claim 11, in which Z-W is a l-methyl-4-phenylbutoxy group. 13. A compound having the formula EMI155.1 14. A compound as claimed in claim 1 or claim 2, in which A and B taken together are oxo, R1 is hydrogen or benzyl, and R3 in Y is cyano. 15. A pharmaceutical composition comprising a compound as claimed in claim 1, other than a compound in which either B is mandeloyloxy or R6 is mandeloyl, or in which R is benzyl, together with a pharmaceutically acceptable carrier material. 16. A diastereomeric bis-mandelate of a compound of the formula EMI155.2 where R1 is benzyl and s is 1 or 2. CLAIMS FOR AUSTRIA 1. A process for preparing a compound of the formula EMI156.1 wherein A when taken individually is hydrogen; B when taken individually is hydrogen, hydroxy, mandeloyloxy, alkanoyloxy having from one to five carbon atoms, amino or acetamido; A and B when taken together are oxo; R1 is hydrogen, alkanoyl having from one to five carbon atoms, P(O)(OH)2 and mono- and disodium and potassium salts thereof, -CO(CH2)2COOH and the sodium and potassium salts thereof, or -CO(CH2)NR4R5; p is 0 or an integer from 1 to 4; each of R4 and R5, when taken individually, is hydrogen or alkyl having from one to four carbon atoms; or R4 and R5, when taken together with the nitrogen to which they are attached, are piperidino, pyrrolo, pyrrolidino, morpholino or N-alkylpiperazino having from one to four carbon atoms in the alkyl group; s is an integer of 1 or 2; Y is -CH(R2")CH(R2)- or -CH(R3)CH2-; R2" is hydrogen or methyl; R2 is hydroxy or X-substituted alkyl having from one to six carbon atoms; R3 is hydroxy, cyano or X-substituted alkyl having from one to three carbon atoms; X is -OR6, -NR6R7, -COOR7, -CONR7R8 or oxo; R6 ' is hydrogen, alkyl having from one to six carbon atoms1 acetyl or. mandeloyl; each of R7 and R8 is hydrogen or alkyl having from one to six carbon atoms; provided that when X is -NR6R7, -COOR7 or -CONR7R8, it is located on the terminal carbon atom of R2 or R3; and when R6 in -NR6R7 is acetyl, R7 is hydrogen; W is hydrogen, pyridyl or EMI157.1 wherein W1 is hydrogen, chloro or fluoro, provided that when W is hydrogen, Z is alkylene or oxaalkylene having from five to thirteen carbon atoms; and when W is other than hydrogen, Z is alkylene or oxaalkylene having from three to eight carbon atoms; or a pharmaceutically acceptable acid addition salt of those compounds which contain a basic group, which comprises (a) reacting an appropriately substituted and protected 2-bromophenol of the formula EMI157.2 with magnesium in a reaction-inert solvent and an appropriately substituted 2-cycloalken-l-one of the formula EMI158.1 (or a precursor thereof) to form a compound of the formula (IA) (or precursor thereof) in which A and B together are oxo; or (b) reacting the copper derivative of an appropriately substituted and protected phenol of the formula EMI158.2 (or precursor thereof)with the said 2-cycloalken-l-one (or precursor thereof) to form a compound of formula (IA) (or precursor thereof) in which A and B together are oxo; or (c) selectively alkylating a ketal of an appropriately substituted 3-(2,4-dihydroxyphenyl)-cycloalkanone of the formula EMI158.3 (or a precursor thereof) to form a compound of formula (IA) (or precursor thereof) in which A and B together are oxo, R1 is H, and Z-W is O-alk-W; or (d) reacting an appropriately substituted 5-(2benzyloxyphenyl)-2-cycloalken-l-one of the formula EMI159.1 with sodium or potassium cyanide to form a compound of formula (IA) (or precursor thereof) in which A and B together are oxo and Y is -CH(CN)CH2-; or (e) oxidizing an appropriately substituted phenylcycloalkenone of the formula d EMI159.2 to form the corresponding epoxide ana then reducing the epoxide to form a compound of formula (IA) (or precursor thereof) in which A and B together are oxo and Y is -CH2CH(OH)- or -CH(OH)CH2-; if necessary (f) converting any precursor so formed to a compound of formula (IA); and, if desired (g) reducing any compound formed in (a) to (f) to a compound in which A is hydrogen and B is hydroxy, and, if desired, acylating the compound in which B is hydroxy to form a compound in which B is alkanoyloxy or mandeloyloxy, or reacting the compound in which B is hydroxy with phthalimide, triphenylphosphine and diethylazodicarboxylate.to form a compound in which B is amino; ; (h) converting any compound formed in (a) to (f) to a hydrazone or semicarbazone thereof and decomposing the hydra zone or semicarbazone to form a compound in which A and B are each hydrogen; (i) converting any compound formed in (a) to (f) to an oxime thereof and reducing the oxime to form a compound in which A is hydrogen and B is amino and, if desired, acetylating the compound in which B is amino to form a compound in which B is acetamido; or (j) converting any basic compound so formed to a pharmaceutically acceptable acid addition'salt, 2. A process according to claim 1, wherein the precursor used in any of reactions (a) to (e) is a compound in which R2 or R3 in Y is replaced by an alkenyl group, which is then hydrated to form a compound in which R2 or R3 is a hydroxyalkyl group and, if desired, oxidized to a compound in which R2 or R3 is an oxoalkyl group. 3. A process according to claim 1, wherein the precursor used in any of reactions (a) to (e) is a compound in which R2 or R3 in Y is replaced by a ketal derivative of an oxoalkyl group, which is then deketalised to a compound in which R2 or R3 is an oxoalkyl group. 4. A process according to claim 3 or claim 4, wherein the compound in which R2 or R3 is an oxoalkyl group (or is replaced by a ketal derivative thereof) is then subjected to the Witting reaction to form compounds in which R2 or R3 has an increased carbon chain length. 5. A process according to claim 1, wherein the precursor used in any of reactions (a) to (e) is a compound in which R2 or R3 in X is replaced by a benzyloxyalkyl group, which is 'then debenzylated to a compound in which R2 or R3 is a hydroxyalkyl group. 6. A process according to claim 2 or claim 5, wherein the compound in which R2 or R3 is a hydroxyalkyl group is alkylated to a compound in which R2 or R3 is an alkoxyalkyl group. 7. A process according to claim 1, wherein a compound so formed in which Y is -CH(CN)CH2 - is converted to a compound in which Y is -CH(CHO)CH2- by reaction with diisobutyl aluminium hydride and then reduced to a compound in which Y is -CH(CH2OH)CH2-. 8. A process according to claim 1, wherein the precursor used in reaction (b) is a compound in which Z-W is replaced by an alkenyl group, which is then hydrogenated.

Inventors: JOHNSON, MICHAEL ROSS, MELVIN, JR., LAWRENCE SHERMAN
Applicants: PFIZER INC.
Application year: 1981
Main classification: C07C43
IPC codes: C07C233, C07C47, C07C255, C07C231, C07C67, C07C45, A61K31, C07C39, A61P25, C07C33, C07D303, C07C219, C07C217, C07C253, A61P29, C07D209, C07C213, C07C43, A61P1, C07C49, C07C59, C07C235, C07C223, C07C35, C07C69, C07C215, C07C27, C07D213