GERM-KILLING COMPOSITION

Abstract: A germ-killing composition, such as a soap, toothpaste or ointment includes a first material, in the form of a solution or gel, containing sodium chlorite, and a second material, also in the form of a solution or gel, containing lactic acid, the latter being present in sufficient amount to lower the pH of the aqueous media to less than about seven. Various forms of dispenser may be employed to accommodate the two materials separated from one another and to dispense them simultaneously, such as a syringe comprising housing (20) divided by partition 22 and having coupled pistons (26, 28) for ejecting the materials simultaneously.

Description: GERM-KILLING COMPOSITION SPECIFICATION This invention relates to germ-killing compositions or materials, and more particularly to materials adapted for use in cleaning, sanitizing, deodorizing, and disinfecting surfaces into or onto which the material is to be applied. Chlorine dioxide (C102) has been tried in the past for skin disinfection with limited success. One such chlorine dioxide preparation was called Cryoclave, produced by International Dioxide. Chlorine dioxide has, however, had more success as an additive to medicine to inhibit microbial growth in the medicine itself, as disclosed in Canadian Patent Specification Jo. 955 848, than for its antimicrobial activity on the body. A common method for using or incorporating chlorine dioxide gas into products has been to dissolve the gas in a liquid to form a solution. This method has a number of drawbacks. The chlorine dioxide gas tends to escape from the solution so that its shelf lMte is relatively short compared with other skin medications. When the product is applied to the skin or a lesion as a liquid, lack of adhesion of the product to the skin or lesion results in a short contact time. Since fungal diseases and other types of infected lesions usually require many hours or even days of contact for effective treatment thereof, a strict regimen of reapplication would be necessary to ensure adequate therapeutic response. These objections to the use of chlorine dioxide on the skin can be overcome or substantially alleviated if the gas is incorporated in a gel base. The high viscosity of these gels and their bioadhesion to the skin prevents escape of the gas and also holds the gas in contact with the skin for long periods, particularly in conjunction with the use of a conventional occlusive barrier, such as a plastic film bandage, for the afflicted area. The process of acidifying sodium chlorite to produce chlorine dioxide within the gel is novel. The gelling material must not only be compatible with the strong oxidizing action of chlorine dioxide, so that there is no complexing with this reactive substance, but must also be compatible with the alkaline sodium chlorite and the acid. Many substances are not compatible with chlorine dioxide. Most flavours and colouring agents, for example, will react with chlorine dioxide. Canadian Patent Specification No. 955 848 discloses adding these kinds of substances, but this addition reduces the germicidal effectiveness of the chlorine dioxide and thus shortens thu shelf life of the product. A further example of incompatibility is hydrogen peroxide, which has been successfully gelled with a glycerin base. Glycerin, however, will react with chlorine dioxide and therefore cannot be used as a thickener for a base with chlorine dioxide producing components. The gelling agent must, of course, be non-toxic, non-irritating, and easily removed from the skin. Thus, the primary object of the present invention is to provide an improved germ killing composition which may be incorporated in or constitute cleaning, deodorizing, sanitizing, and disinfecting materials including gels, soap products, toothpaste, and the like, wherein these disadvantages are obviated. With this object in view, the present invention provides a germ-killing composition comprising two solutions or gels adapted to be simultaneously applied and mixed in situ, and one of which contains sodium chlorite, characterised in that a first one of said solutions or gels is an aqueous eolu- tion or gel comprising sodium ohlorite, and that the second of said solutions or gels is an aqueous solution or gel comprising lactic acid, there being sufficient of said lactic acid to lower the pH of the compssttion to less than about 7. A product according to the invention may be packaged to comprise one material containing the sodium chlorite separate from another material containing the lactic acid in sufficient amount to lower the pH of the final product, formed upon mixing of the materials together, to less than about 7. The invention is illustrated, by way of example, in more detail, by the accompanying drawings in which:- Pig. 1 is a longitudinal sectional view of a dual syringe used in dispensing the germ-killing composition according to one aspect of the invention; Fig. 2 is a longitudinal sectiOnal view of a single syringe having dual compartments for dispensing the germ-killing composition according to a second aspect of the invention; Fig. 3 is a schematic diagram showing a dual reservoir applicator and illustrating a third aspect of the inrention; Fig. 4 is an exploded perspective view showing a squeezable vial and illustrating a fourth aspect of the invention; Fig. 5 is an exploded perspective view showing a rigid double dispenser and illustrating a fifth aspect of the invention; ; 'Fig. 6 is a sectional detail view of a triggertype dual dispenser to illustrate a sixth aspect of the invention; ?ig. 7 is a schematic view showing another form of dual dispenser to illustrate a seventh aspect of the invention; Fig. 8 is an elevational view of a dual dispensing plastic pack having a removable separator, illustrating an eight aspect of the invention; Fig. 9 is a view of the dispenser shown in rig. 8, but with ite separator removed; Fig. 10 is a sectional detail view of a squeeze bottle having a centre separator, to illust- rate a ninth aspect of the invention; ; Fig. 11 is a sectional detail view illustrating means which may be incorporated in a dispenser, such as that of Fig. 10, for preventing unequal dispensing of its separate contents; Fig. 12 is a sectional detail view illustrating a modified form of means for controlling the iluid flow of the separate contents of a dispenser such as that of Fig. 10; and detail Fig., 13 is a sectionalfiiew of yet another form of such a control means. The present invention is further illustrated by the following examples. ill parts and percentages as recited in the examples as well as in the specification and claims are by weight, unless otherwise specified. Example I. This Example illustrates the production of a germ-killing composition conforming to the invention and in the form of a gel comprising two constituents or parts which are mixed in situ. This gel is most effective in the treatment of burns and is efficacious in killing germs on all surfaces. It is parti cularly useful for the treatment of acne. GEL PART A Thickener- METHYL CELLULOSE (High Viscosity. 4,000 CPS) 8.0% w/w Preservative - BENZYL ALCOOHOL 5.0 % W/W WATER 85.7 % W/W LACTIC ACID 1.3 % W/W PART 3 METIlYL CELLULOSE (High Viscosity, 4,000 CPS) 8.0 % W/W BENZYL ALCOHOL 5.0 % W/W WAtER 86.8 SODIUM CHLORITE 0.2 % W/W The procedure for preparing Part A is as follows: Heat one-half of the 85.7% water to boiling point and add methyl cellulose, with constant agitation. Add the balance of the water as Wice water" (i.e. at a temperature of about 5 C.) containing the benzyl alcohol and the lactic acid. Stir initially to blend the ingredients; then allow them to cool to room temperature with occasional stirring until the composition gels. The procedure for preparing Part 3 is the same as for Part A, except that sodium chlorite is involved in the place of the lactic acid. The parts A and 3 are then packaged in separate tubes with directions to mix equal parts before use. Example II This Example illustrates a soap product which employs lactic acid and sodium chlorite. STRIPED SOAP hAR Detergent - IGEPON AC- 78 (83% solids) (1) 58% W/W Preservative - ViNCIDE 89 RE (2) 1% W/W Thickener - VEEGUM F (2) 1 % W/W Emolient - CETYL ALCOHOL 2 % W/W Emulsificator - GLYCERYL MONOSTEARATE A.S. 6 % W/W Emulsifier - STEARYL ALCOHOL 7% W/W Emollient - MODULAN (3) 3%W/W Humectant - POLYETHYLENE GLYCOL 6000 13%w/W WATER 9%W/W (1) Commercially available from GAF Corporation, New York, N.Y. (2) Commercially available from the R.T. Vanderbilt Co., New York, 5,Y. (3) Commercially available from the American Cholesterol Products, Inc., Edison, N.J Procedures Add the VANCIDE 89RE and the VEEGUM P to a part of the IGEPON AC - 78, then add the rest of the IGEPON AC - 78 with thorough blending. Heat a mixture of the remaining ingredients to 75 C. Add the IGEPON mixture to the remaining ingredients with agitation until uniform. Divide the mixture into two parts, A and B. To Part A, add 1% W/W sodium chlorite, and to part B add 6% /W lactic acid plus 1% w/w Tartrazine Dye (F. D. & C.). Allow Parts A and B to cool to room temperature and gently bland the two parts to produce swirls of the Part B, which is yellow, in the Part A, which is white. Press them resultant mixture into bars or cakes. EXAMPLE III This invention may also be used in producing a toothpaste as described hereinbelow. STRIPED TOOTHPASTE Thickener - VEEGUM P 1.25 w/w Thickener - METHYL CELLULOSE (Medium viscosity, 400 CPS) 0.70% W/W WATER 24.00 % W/W Humectant - SORBITOL (70% Aqueous solution) 25.00% W/W Abrasive - DICALCIUM PHOSPHATE DIHYDRATE 45.00% W/W MINT FLAVOUR 1.00% w/w Detergent - SODIUM LAURYL SULPHATE 1.50 % W/W Preservative - METHYL PARABEN 0.25 % W/W LACTIC ACID 1.30% W/w All of the Thickener may be METHYL CELLULOSE. Procedure: Dry blend the VEEGUM F and METHYL CELLULOSE. Add this blend to the water (heated to 70 C.) slowly, agitating continuously until uniform, and cool-to room temperature. Add the SORBITOL solution and DICALCIUM PHOSPHATE DIHYDRATE in alternate portions to the VEEGUM F/METHYL CELLU LOSE mixture until smooth. Then add the LACTIC ACID, MINT FLAVOUR, METHYL PARABEN and SODIUM LAURYL SULPHATE in order, blending each thoroughly (using gentle agitation) with the SODIUM LAURYL SULPHATE to avoid incorporation of air. This prodoes a white tooth paste. In a separate operation, prepare the following gel: Thickener - METHYL CELLULOSE (High Viscosity, 4000 CPS) 8.0% W/W Preservative - BENZYL ALCOHOL 5.0% w/w Colour - ERYTHROSIN J (F.S. & C.) 1.0% W/W WATER 85.8% W/W SODIUM CHLORITE 0.2 W/W Procedure: Heat one-half of the water to boil ing and add the METHYL CELLULOSE with constant agitat ion. Add the balance of the water as "ice water" (about 5 C.), containing the BENZYL ALCOHOL, ERYTHROSIN J (Cherry-red dye) and SODIUM CHLORITE. Stir initially to blend the ingredients; then allow the blend to cool to room temperature with occasional stirring until gelled. Package the white toothpaste and the red gel in plastic tubes with separate compartments for but each component, /with adjacent extrusion orifices providing for the toothpaste to emerge as a single stream and for the gel to emerge by way of several small orifices arranged around the periphery of the toothpaste orifice so that a striped effect is produced upon extrusion. Such tubes are commercially available. The following description refers to the accom- panying drawings wherein like reference numerals designate similar parts throughout the various views. Each figure illustrates a respective dispenser or like device for dispensing the two parts or components of a germ-killing preparation of the invention, comprising respectively the sodium chlorite and the lactic acid as above discussed. In rig. 1 there is shown a dual syringe espeoially adapted for use in dispensing a germ-killing composition in accordance with the invention, in the form of solutions or gels and comprises a syringe housing 20 provided with a partition or separator 22. A single actuator 24 controls dual plungers 26 and 28 which serve to expel the separate contents from the housing 20 simultaneously. and in equal amounts as indicated at 30 as a material or composition ready to be spread evenly on a surface to be treated. In Fig. 2 there is shown a syringe comprising a housing 40 having a single plunger 44 which, when actuated, causes material 46 to break through a frangible barrier 48 and mix with the material 50 so that the combination of ingredients forming the germ-killing composition is expelled as composite gel 52 which is ready for use. Fig. 3 shows an arrangement comprising two reservoirs 60 and 62 interoonneoted by tubing 64 with separate control valves 66 and 68 and provided with a shut-ofi valve 70 for controlling fluid flow in the direction oi arrow 72. there In Fig. 4/is shown a equeezable vial 80 containing frangible containers 82 and 84 which will break, upon application of pressure to the vial 80, to permit the ingredients, contained in each container 82, 84, to admix and to be delivered as a germ-killing composition through a cotton doubter 86 in a convenient manner. Fig. 5 shows z dual applicator including two containers 90 and 92 filled respectively with the two different materials and each having a sponge applicator head 94 and 96 for simultaneously applying the two materials to form the germ-killing composition. The two containers 90 and 92 are bonded or otherwise join 'ed together. In Fig. 6 there is shown a trigger-actuated dispenser in which a container 100 is provided with z divider 102 for maintaining solutions 104 and 106 separate. When trigger 108 of conventional pump actuator 110 is depressed, the materials are sucked through the respective tubes 112 and 114 and are sprayed simultaneously to form the germ-killing composition on a receiving surface, not shown0 Fig. 7 shows a dual dispenser, similar to a foam shaving cream dispenser marketed by the Gillette Company, in which an outer container 130 encloses a first material and an inner container 132 which contains a second material which is thereby separated from the first material. Both such materials are under gas pressure and when actuator 134 is depressed, both materials are simultaneously dispensed as a germ-killing composition as a result of the gaseous pressure. Referring now to Figs. 8 and 9, a plastic container 200 is firstly partially filled with one solution after which a removable separator 202 is applied around the container 200 to confine this one solution to one end of the container. Thereafter, the other unfilled section of the container is filled through its neck 204 and cap 206 secured in place. When it is desired to use the contents, the separator is removed and, as shown in Fig. 9, the entire oontents are mixed to form the germ-killing composition which ia then ready for application. Sn Fig. 10 there is shown a tube or container 220 including a separator 22 whereby the two components forming the germ-killing composition of the invention are kept apart. Provided on the bottom of the tube on or container 220 is a tab 224/which a wind-up key 226 can be used to expel the contents of the container 220 simultaneously in equal proportions. Referring now to Fig. 11, this shows a container 240 having a divider 242 therein. The container 240 is thereby adapted to contain two different gels 244 and 246 and flow of the gel 244 through its passage through neck 260 of the container 240 without corre- ponding flow of the gel 246 through its passage has the effect of actuating a pivotal valve member 250 to prevent passage of the gel 244 and vice versa. For example, if gel 244 flows and gel 246 does not, vanes 254 moves into valve-closed engagement with valve seat 256 while valve head 258 contacts the neck 260 to prevent flow of the gel 244. Even flow of both gels allows the vanes to stay in the illustrated position and permit equal delivery. Fig. 12 shows another form of container 280 incorporating a separator2282 as well as a guide 286 at neck 288 of the container 280 and is so arranged that the guide 286 will lock upon movement or flow of one only of the gels within the container so as to cause an appropriate one of the valve vanes 290 and 292 to prevent further flow until the delivery of both gels is equalized. In Pig. 13 there is shown another modified form of dispenser comprising container 300 haTing a divider 302 therein for separating compartments 304 and 306, containing different gels, from each other. Pivoted to the divider 302 is a valve assembly 310 which includes means for preventing unequal flow of the separate gels. As has already been mentioned, each of the illustrated dispensers is intended to be loaded separately with the respective sodium chlorite-containing and lactic acid-containing components of the germ-killing preparations of the invention; for these components to be stmultaneously dispensed and mixed to form the inventive composition, e.g. in situ or preparatory to use. The principles, preferred aspects and examples, of the present invention have been described in the foregoing specification. The invention which is intended to be protected herein, however, is not to be construed as limited to the particular forms or examples disclosed, since these are to be regarded as illustrative rather than restrictive. Variations and changes may be made by those skilled in this art without departing from the scope oi the invention, as defined by the following claims.

Claims: CLAIMS 1. A germ-killing composition comprising two solutions or gels adapted to be Bultaneously applied and mixed in situ, and one of which contains sodium chlorite, characterised in that a first one of said solutions or gels is an aqueous and solution or gel comprising sodium chlorite,/that the second of said solutions or gels is an aqueous solution gel comprising lactic acid, there being sufficient of said lastic acid to lower the pH of the composition to less than about 7. 2. A composition as claimed in claim 1 characterised in that said first solution or gel includes 0.2% by weight sodium chlorite and said second solution or gel includes 1.3 by weight lactic acid. 3. A composition as claimed in claim 1 or 2, characterised in that said first solution or gel and said second solution or gel each include approx imately 8% by weight of methyl cellulose and approximately 5% by weight of benzyl alcohol. 4. A composition as claimed in claim 1, 2 or 3 characterised in that said first and second solutions or gels each contain a thiokener and a preservative. 5. s composition as claimed in claim 4, characterised in that said thickener is methyl cellulose and said preservative is benzyl alcohol.

Inventors: ALLIGER, HOWARD
Applicants: ALCIDE COMPANY LIMITED PARTNERSHIP
Application year: 1981
Main classification: A01N59
IPC codes: A01N59