AMIDES OF 4-OXO-5-AMIDOHEXANOIC ACID DERIVATIVES

Abstract: The invention concerns novel amide derivatives of the for­ mula: R¹-Y-NR²-CHR³-X-CHR¹¹-CHR⁴-CO-NR⁵-CR⁶R¹⁶-Q-R¹⁰ wherein R¹, R², R³, R⁴, R⁵, R⁶, R¹⁰, R¹¹ and R¹⁶ are various substituents defined hereinafter, Y is carbonyl, thiocarbonyl, sulphonyl or amido, X is carbonyl, hydroxymethylene, thiocar­ bonyl or oximinomethylene and a is carbonyl or methylene, or a salt thereof, which are inhibitors of angiotensin converting en­ zyme and may be used for example, in the treatment of hyper­ tension. The invention also provides pharmaceutical composi­ tions of and processes for the manufacture of the novel amide derivatives.

Description: AMIDES OF 4-OXO'- -AM DOHEXANOIG ACID DERIVATIVES This invention relates to new amide derivatives and more particularly it relates to amide derivatives which are inhibitors of angiotensin converting enzyme (hereinafter ACE). Various inhibitors of ACE are known. One is commercially available under the name captopril and has the chemical structure: EMI1.1 Another, known as MK 421, is at an advanced stage of clinical trial and this has the chemical structure: EMI1.2 Various analogues of these compounds are described in the literature, especially in patent specifications. No ACE inhibitor is known, however, which bears a ketonic group in the chemical structure, and there are now herein for the first time provided such compounds. According to the invention there is provided an amide derivative of the formula: R1-Y-NR2-CHR3-X-CHR11-CHR4-CO-NR5-CR6R16-Q-R10 wherein either R1 is hydrogen, or alkyl of up to 15 carbon atoms which is unsubstituted, or which bears one substituent selected from amino, benzyloxycarbonylamino, hydroxy, alkoxy, alkylthio and alkoxycarbonyl each of up to 5 carbon atoms, and aryl, aryloxy and arylthio substituents; or which bears two or three substituents one of which is aryl,another of which is aryl, hydroxy, amino, benzyloxycarbonylamino, trifluoromethyl, aryloxy or alkoxy of up to 5 carbon atoms and the third of which, if present, is aryl or trifluoromethyl; or R1 is aryl or, when Y is carbonyl or thiocarbonyl, is aryloxy, alkoxy or arylalkoxy wherein the alkoxy part has up to 5 carbon atoms; or R1 is halogenoalkyl of up to 6 carbon atoms or is alkenyl, halogenoalkenyl or cycloalkyl each of up to 6 carbon atoms which is unsubstituted or which bears an aryl substituent; ; or R1 is a substituent of the formula R8CONHCHR9- or R8COCH2CHR9- wherein R8 is alkyl or cycloalkyl each of up to 10 carbon atoms, or aryl and R9 is hydrogen, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R9 is a group other than those stated above such that the compound H2NCHR9COOH would be a common amino acid; wherein R2 is hydrogen, alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or aryl; wherein R3 is alkyl or alkenyl each of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R3 is aryl or indolylmethyl; wherein R4 is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent; wherein either R5 is hydrogen or aryl, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R5 is joined together with R6 as defined below; wherein either R6 is hydrogen, aryl or heterocyclic, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears a hydroxy, aryl or heterocyclic substituent; or R6 and R5 are joined together to form alkylene or alkenylene of 2 to 5 carbon atoms; or an oxa, thia or aza-derivative of said alkylene or alkenylene; or a hydroxy-or oxo-substituted derivative of said alkylene or alkenylene; or R6 and R16, or R6, R16 and R5, or R6 and R10 are joined together as defined below; wherein R16 is hydrogen or alkyl of up to 5 carbon atoms; or R6 and R16 are joined together to form alkylene of 2 to 5 carbon atoms (that is, to form a spirocycloalkyl group); or R16 together with the first carbon atom of R6 form a double bond wherein R6 is otherwise alkyl, or wherein R6 is otherwise substituted alkyl as defined above, or wherein R6 and R5 are otherwise S joined together as defined above (that is, so that R and R16 together form alkylidene); wherein Q is carbonyl (-CO-) or methylene (-CH2-); ; and wherein either R10 is hydroxy, amino, aryloxy, arylthio, alkoxy, cycloalkoxy, alkylamino, dialkylamino, cyclic amino, hydroxyalkoxy, acyloxyalkoxy, aminoalkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, cyclic aminoalkoxy, aminoalkylamino, alkylaminoalkylamino, dialkylaminoalkylamino, cyclic aminoalkylamino or arylalkoxy wherein each alkyl or alkoxy has upto 5 carbon atoms and wherein cyclic amino has up to 6 carbon atoms; or wherein R1O and R6 are joined together such that R1O is oxygen (-0-) joined to the terminal carbon atom of R6 when it is alkyl; wherein R11 is hydrogen or alkyl of up to 3 carbon atoms; ; wherein X is carbonyl (-CO-), hydroxymethylene (-CHOH-), thiocarbonyl (-CS-) or oximinomethylene C-C=N-OR20.-wherein R20 is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent); and wherein Y is carbonyl, thiocarbonyl, sulphonyl C-SO2-) or amido (-NHCO-); cr a salt thereof where appropriate. It will be observed that there are various potentially asymmetrical carbon atoms in the amide of the invention, in particular the carbon atoms which bear the substituents R3, R4 and R11 when these substituents are other than hydrogen, and the carbon atom which bears the substituents R6 and R16 when these are different one from the other , and that the amide may therefore exist in racemic and optically active forms. It is to be understood that this invention encompasses the racemic form and any optically-active form which possesses ACEinhibiting properties, it being a matter of common general knowledge how an optically active compound may be prepared and how the ACE- inhibiting properties of a compound may be measured. A suitable value for R1 or R8 when it is alkyl is, for example, methyl, isobutyl or n-tridecyl. A suitable value for R2, R3, 4 5 R6, R9, R16 or R20 when it is alkyl is, for example, methyl, ethyl,n-propyQ or isobutyl. A suitable value for R11 when it is alkyl is, for example, methyl or ethyl. A suitable value for R1 or R when it is alkoxy, or for the alkoxy substituent in R1 when said group is alkyl substituted b alkoxy is, for example, methoxy, ethoxy or t-butoxy0 A suitable value for R1 or R3 when it is alkenyl, is, for example, allyl or 2-methylprop-2-enyl. A suitable value for R1 or R8 when it is cycloalkyl is, for example, cyclopropyl, cyclopentyl or cyclohexyl. A suitable value for R1, R2, R3, R5,R6 or R8 when it is aryl, or for the aryl substituent in the group R1 R2 R3 R4 R5 R6, R9 or R20 when said group is alkyl substituted by aryl, or for the aryl substituent in R1 when said group is alkenyl, halogenoalkenyl or cycloalkyl substituted by aryl, or for the aryl substituent in R3 when said group is alkenyl substituted by aryl, or for the aryl substituent in R1 or R10 when it is arylalkoxy, that is, alkoxy substituted by aryl, is, for example, unsubstituted phenyl or naphthyl, or phenyl or naphthyl substituted by one or more substituents selected from halogen, for example fluorine, chlorine,bromine and iodine , alkyl, alkenyl, alkynyl, alkylthio and alkoxy each of up to 5 carbon atoms, for example methyl, ethyl, t-butyl, allyl, propargyl, methylthio, methoxy and ethoxy, and hydroxy, methylenedioxy, amino, nitro, cyano, carboxy, carbamoyl, trifluoromethoxy and trifluoromethyl, aryl, for example phenyl and ±-chlorophenyl, and substituents of the formula -COR" -NHR -NR30R31 -C00R30 -CONHR CoNR3OR3 -NHC0R30 -NHS02R30 -SC 2NR 30R31 -SR30 -SOR30 'S02R30 - (alk) -COR30 - (alk) -COOR30 wherein either R30 and R31, which may be the same or different, each is phenyl, or trifluoromethyl,or alkyl of up to 5 carbon atoms, for example methyl, methyl or n-propyl, which is unsubstituted or which is substituted by phenyl, or R30 and R31 are joined such that together with the adjacent nitrogen atom they form pyrrolidino, carboxypyrrolidino, alkoxycarbonylpyrrolidino, piperidino, 4-methylpiperazino or morpholino, and wherein -alk- is alkylene of 1 to 4 carbon atoms. A suitable value for R1 or R10 when it is aryloxy, or for the aryloxy substituent in Ri when Rl is alkyl snbstituted by aryloxy, is, for example, unsubstituted phenoxy or phenoxy substituted by one or more substituents selected from those stated above as suitable substituents in aryl. A suitable value for 210 when it is arylthio, or for the arylthio substituent in R1 when R1 is alkyl substituted by arylthio is, for example, unsubstituted phenylthio or phenylthio substituted by one or more substituents selected from those stated in the penultimate paragraph as possible substituents in aryl. A suitable value for the alkylthio or alkoxy carbonyl substituent in R1.when it is alkyl substituted by alkylthio or alkoxycarbonyl is, for example, methylthio or ethoxycarbonyl. A suitable value for R1 when it is halogenoalkyl or halogenoalkenyl is, for example, trifluoromethyl or l-chlorovinyl. A suitable value for R6 when it is heterocyclic, or for the heterocyclic substituent in R6 when it is alkyl substituted by heterocyclic, is, for example indolyl. A suitable value for lkylene or alkenylene rO= d by R5 and R6 joined together is, for example, ethylene, trimethylene, tetramethylene, pentamethylene, propenylene (-CH2-CH-CH-), but-l-enylene (-CH2CH2-CH=CH-), 2-oxatrimethylene (-CH2-O-CH2-), 2-thiatrimethylene (-CH2-S-CH2-), 3-oxatetramethylene (-CH2CH2-O-CH2-), 3-thiatetramethylene (-CH2CH2-S-CH2-), 3-azatetramethylene (-CH2CH2-NH-CH2-), 3-methyl-3 -azatetramethylene EMI7.1 2 -hydroxy- trimethylene (-CH2CHOHCH2-), l-oxotrimethylene (-COCH2CH2-) or l-oxotetramethylene (-COCH2CH2CH2-). A suitable value for alkylene formed by R6 and R16 joined together, is, for example ethylene, trimethylene or tetramethylene. A suitable value for alkylidene formed by R5, R6 and R16 joined together is, for example, propan-l-yl3-ylidene (-CH2CH2CH=). 9 A suitable value for R when it is a group derived from a common amino acid is, for example, 3aminopropyl (from L-ornithine), 4-aminobutyl (from L-lysine), hydroxymethyl (from L-serine), a-hydroxyethyl (from L-threonine), S-hydroxyethyl (from L-homoserine), mercaptomethyl (from L-crysteine), -methylthioethyl (from L-methionine), 3-guanidinopropyl (from L-arginine), imidazol-4-ylmethyl (from L-histidine), carboxymethyl (from L-aspartic acid) or 2-carboxyethyl (from glutamic acid). A suitable value for R10 when it is cycloalkoxy, hydroxyalkoxy or acyloxyalkoxy is, for example, cyclopentyloxy, cyclohexyloxy, 2-hydroxyethoxy, 3-hydroxypropoxy or pivaloyloxymethoxy. A suitable value for R10 when it is alkylamino, dialkylamino or cyclic amino is, for example, methylamino, ethylamino, dimethylamino, pyrrolidino, piperidino, 4-methylpiperazino or morpholino. A suitable value for R when it is aminoalkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, cyclic aminoalkoxy, aminoalkylamino, alkylaminoalkylamino, dialkylaminoalkylamino or cyclic aminoalkylamino is, for example, ethoxy, propoxy ,ethylamino or propylamino substituted in the 2- or 3- position respectively by amino, methylamino, ethylamino, dimethylamino, pyrrolidino, piperidino, 4-methylpiperazino or morpholino. Alternatively, R10 when cyclic aminoalkoxy or aminoalkylamino may be a cyclic amine bearing an oxy- or amino-substitllent on one of the carbon atoms of the cyclic amine, for example l-methyl piperidir -4-yloxy or l-methylpiperidin-4-ylamino. When Q is carbonyl and R6 and R10 are joined together the group -CR6R16-Q3-R10- may be, for example, the lactone group 2-oxotetrahydrofuran-3-yl or 2-oxotetrahydropyran-3-yl. Preferably X,Yand Q are all carbonyl and R2 and R11 are both hydrogen. One preferred amide derivative of the invention has the formula given above wherein R1 is alkyl of up to 15 carbon atoms which is unsubstituted or which bears an aryl, aryloxy or arylthio substituent, or R1 is aryl or aryloxy, or R1 is a substituent of the formula R8CONHCHR9- or R8COCH 2CHR 9- wherein R8 is alkyl or cycloalkyl each of up to 10 carbon atoms, or aryl, and R9 is hydrogen, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R9 is a group other than those stated above such that the CI compound H2NCEP-COCE would be a common amino acid; wherein Y and R2 have the meanings stated above; wherein R is alkyl or alkenyl each of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R3 is aryl or indolylmethyl; wherein X is carbonyl, hydroxymethylene, thiocarbonyl or oximinomethylene ('C=N-OH); wherein R11 is hydrogen; wherein R4 is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent; wherein either R5 is hydrogen, aryl or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, R6 is hydrogen, alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl or heterocyclic substituent, or R6 is heterocyclic or aryl, and R16 is hydrogen; or R5 and R6 are joined together to form alkylene or alkenylene of 2 to 4 carbon atoms; or an oxa, thia or aza-derivative of said alkylene or alkenylene; or R6, R16 and R5 are joined together such that R16 together with the first carbon atom of R6 form a double bond wherein R6 and R5 are otherwise joined together as defined above wherein Q is carbonyl; and wherein R10 has the formula -OR7, wherein R7 is hydrogen or alkyl of up to 5 carbon atoms. Thus, a preferred amide derivative has the formula: EMI9.1 wherein R1, R2, R3, R4, R5, R6 R7 R16, X and Y have the meanings stated in this paragraph. A particularly preferred amide derivative of the invention has the formula R1CONH-CHR3-COCH3-CHI -CHR6-C0R10 wherein R1 is methyl, benzyl, B-phenylethyl, benzyloxy, phenoxymethyl, phenylthiomethyl, phenyl, tolyl, methoxyphenyl, methylthiophenyl, monochlorophenyl, dichlorophenyl, fluorophenyl, iodophenyl, nitrophenyl, cyanophenyl, trifluoromethylphenyl, acetamidophenyl, acetylphenyl, methanesulphonylphenyl, biphenylyl, naphthyl, benzamidomethyl, cyclopentanecarbonamidomethyl or a-benzoylethyl; R3 is benzyl which is unsubstituted or bears a methyl, t-butyl, methoxy, fluoro, chloro, bromo, nitro, cyano, trifluoromethyl, amino, acetamido, me thanesulphonami do, trifluoromethanesulphonamido or phenyl substituent, or R3 is 3-phenylpropyl or 3-phenylprop-2-enyl; ; R4 is hydrogen or methyl; R5 is hydrogen or methyl and R6 is hydrogen, benzyl or indol-3-ylmethyl, or R5 and R6 together form trimethylene, tetramethylene, pentamethylene, 2-hydroxytrimethylene, 2-thiatrimethylene, 3-thiatetramethylene, 3-oxatetramethylene, 3-methyl-3-azatetramethylene; and R10 is hydroxy, amino, alkoxy of up to 5 carbon atoms, especially methoxy, ethoxy, isopropoxyor t-butoxy, or 6-dimethylaminoethoxy or 6-morDholinoethoxy. An especially preferred amide derivative of the invention has the formula EMI10.1 wherein R1 is phenyl, p-acetamidophenyl or E-cyano- phenyl, R3 is benzyl, E-methylbenzyl or p-methoxybenzyl, R4 is hydrogen or methyl and R10 is hydroxy, amino, methoxy, ethoxy, isopropcxyor t-butoxy. Specific compounds of the invention are hereinafter described in the Examples, and of thesepreferred compounds are N-(5-acetamido-2-methyl-4-oxo6-phenylhexanoyl-L-proline, N-(5-benzamido-2-methyl-4oxo-6-phenylhexanoyl)-L-proline and N-(5-phenylacetamido 2-methyl-4-oxo-6-phenylhexanoyl) -L-proline, and salts thereof, and esters thereof with an alcohol of up to 5 carbon atoms, for example methyl and t-butyl esters thereof, and amides thereof. Of these preferred compounds are N- (5-benzamido-2-methyl-4-oxo-6-phenylhexanoyl) -Lproline, and its methyl ester, and its amide. A suitable salt of an amide derivative of the 10 invention wherein R is hydroxy is, for example, an alkali metal or alkaline earth metal salt, for example a sodium, potassium, calcium or magnesium salt, or an ammonium or dicyclohexylamine salt. An amide derivative of the invention may be manufactured by any chemical process known to be suitable for preparing compounds of related chemical types. A preferred process for the manufacture of an amide derivative of the invention comprises the reaction of an acid of the formula: -CHR -COOH wherein R1, R2 R3 R4 Rll X and Y have the meanings stated above, or of a reactive derivative thereof, with an amine of the formula: HNR5-CR6 R16 -Q-R12 wherein R5 R6 R16 and Q have the meanings stated above and wherein R12 has any of the meanings stated above for R10 except those containing a free hydroxy or amino group. The abovementioned reaction may be carried out by reacting the acid and amine together in the presence of a carbodiimide, for example dicyclohexylcarbodiimide, and N-hydroxybenzotriazole, in a diluent or solvent, for example tetrahydrofuran, methylene chloride or dimethylformamide, at ambient temperature or below. The acid starting material for the above reaction wherein R2 is hydrogen and X and Y are both carbonyl, that is, having the formula: R1CONH-CHR3-C0-CNR11 -CHR4-COOH may be obtained by the reaction of a compound of the formula : - EMI12.1 wherein R1 and R3 have the meanings stated above, with an acid chloride of the formula: ClCO-CHR11-CHR4-C00R13 wherein R4 and R11 have the meanings stated above and wherein R13 is alkyl of up to 5 carbon atoms, followed by the hydrolysis of the oxazolone ring and also R13 hydrolysis to replace R Ú by hydrogen. The starting material wherein R2 is alkyl, arylalkyl or aryl may be obtained by the reaction of the intermediate thus obtained, wherein R13 is alkyl or has been replaced by hydrogen, with a compound of the formula R2Z, wherein R2 has the meaning stated above and wherein Z is a displaceable group such as a halogen atom or an alkanesulphonyl or arenesulphonyl group, for example a chlorine, bromine or iodine atom or a methanesulphonyl or toluene-p-sulphonyl group. Alternatively, the starting material wherein Rê is hydrogen and X is carbonyl or thiocarbonyl may be obtained by the reaction of a compound of the formula: H2NCHR3X1CHR11CHR4COOR13 wherein R3 R4 Rill and R13 have the meanings stated above and X1 is carbonyl or thiocarbonyl,with a compound of the formula R Ú-Y-ZÚ, wherein R1 and Y have the meanings stated above and wherein Z1 is a displaceable group such as is defined above for Z, or ZÚ is hydroxy (in which case the reaction is carried out in the presence of a carbodiimide or an alkyl chloroformate), or, when Y is amido, with a compound of the formula RlNCO, or, when Y is thiocarbonyl, with a compound of the formula R1CS-SCH2COOH. An alternative process for the manufacture of an amide derivative of the invention wherein R2 is hydrogen and X is carbonyl or thiocarbonyl comprises the reaction of an amine of the formula: H2NCHR3-X1-CHR11CHR4CONR5-CR6R16-Q-R12 wherein R3, R4, R5, R6, R11, R12 R16 Q and X1 have the meanings stated above, with a compound of the formula R1-Y-Z1, wherein R1, Y and Z1 have the meanings stated above. Yet an alternative process for the manufacture of an amide derivative of the invention wherein Rê is hydrogen and X is a carbonyl comprises the reaction of a compound of the formula: Z2-COCHR11CHR4CONR5CR6R16QR12 wherein R4 R5 R6 R11 R12 R16 , and Q have the meanings stated above and Z is a displaceable halogen atom, for examPle the chlorine or bromine atom, with a compound of the formula EMI14.1 wherein R1 and R3 have the meanings stated above, followed by hydrolysis of the oxazolone ring. The last-mentioned reaction may be carried out in the presence of a base, for example triethylamine and/ or 4-dimethylaminopyridine,and it may be carried out in a diluent or solvent, for example tetrahydrofuran. An amide derivative of the invention wherein R2 is alkyl, arylalkyl or aryl (and R10 is R12) may be obtained by reacting the corresponding amide derivative of the invention wherein R2 is hydrogen (and R10 is R12) with a compound of the formula R2 Z, wherein R2 and Z have the meanings stated above. An amide derivative of the invention wherein R3 is unsubstituted or substituted alkyl may be obtained by the hydrogenation of the corresponding compound wherein R3 is unsubstituted or substituted alkenyl. Anamide derivative of the invention wherein R10 is other than hydroxy (that is, wherein Q-R1 forms forms an ester or amide group) may be obtained from the corresponding acid wherein Q-R is COOH by conventional means of ester or amide formation. An amide derivative of the invention wherein Q is carbonyl and R10 is hydroxy may be obtained by the hydrolysis of the corresponding amide derivative of the invention wherein R10 is alkoxy, or, when R10 is t-butoxy, by the acid-catalysed cleavage of said compound. An amide derivative of the invention wherein X is hydroxymethylene may be obtained by the reduction, for example with an alkali metal borohydride, of the corresponding amide derivative of the invention wherein X is carbonyl, and an amide derivative of the invention wherein X is oximinomethylene may be obtained by the reaction of the corresponding amide derivative of the invention wherein X is carbonyl with hydroxylamine or an O-substituted hydroxylamine derivative. AS stated above, an amide derivative of the invention possesses ACE-inhibiting properties. ACE is the enzyme which converts angiotensin I to angiotensin II. The ACE-inhibiting properties of an amide derivative of the invention may be demonstrated by its ability to prevent the cleavage of angiotensin I or of a synthetic peptide related to angiotensin I by ACE. Angiotensin II is a potent constrictor of vascular smooth muscle, and is therefore involved in the control of blood pressure. A compound which prevents conversion of angiotensin I to angiotensin II will therefore lower circulating levels of angiotensin II and cause a fall in blood pressure. An amide derivative of the invention may therefore be used to lower blood pressure in a warm-blooded animal (including a human). At a dose of amide derivative of the invention which lowers blood pressure in an experimental animal, for example a rat, no symptoms of toxicity are apparent. An amide derivative of the invention may be administered to a warm-blooded animal, including man, in the form of a pharmaceutical composition comprising as active ingredient at least one amide derivative of the invention, or a salt thereof, in association with a pharmaceutically-acceptable diluent or carrier therefor. A suitable composition is, for example, a tablet, capsule, aqueous or oily solution or suspension, emulsion, injectable aqueous or oily solution or suspension, dispersible powder, spray or aerosol formulation. The pharmaceutical composition may contain, in addition to the amide derivative of the invention, one or more drugs selected from diuretics, for example bendrofluazide, chlorothiazide and chlorthalidone; and other hypotensive agents, for example ss-adrenergic blocking agents, for example atenolol and propranolol. When used for the treatment of hypertension in man, it is expected that the amide derivatIve of the invention would be given to man at a total oral dose of between 1 mg. and 500 mg. dally, at doses spaced at 6-8 hourly intervals, or at an intravenous dose of between O.1 mg. and 50 nig. Preferred moral dosage forms are tablets or capsules containing between 1 mg. and 100 mg. of active ingredient. Preferred intravenous dosage forms are sterile aqueous solutions of active ingredient containing between 0.1 % and 1 % w/v of active ingredient. The invention is illustrated but not limited by the following Examples : Example 1 Dicyclohexylcarbodi-imide (3.0 g.) was added to a stirred, ice-cooled solution of (R,S)-5-acetamido-(R,S) 2-methyl-4-oxo.-6-phenylhexanoic acid (2.77 g.), N-hydroxybenzotriazole (1.4 g.) and L-proline t-butyl ester (1.88 g.) in dry tetrahydrofuran (35 ml.),and the mixture was allowed to warm up to laboratory temperature and was then stirred at that temperature for 24 hours. Acetic acid (5 ml.) was added and 15 minutes after that addition the mixture was partitioned between ethyl acetate (200 ml.) and aqueous 10% w/v sodium carbonate solution (75 ml.). The ethyl acetate layer was separated, washed successively twice with aqueous 10% w/v sodium carbonate solution, three times with aqueous N-hydrochloric acid and once with saturated aqueous sodium chloride solution, filtered through anhydrous sodium sulphate and evaporated to dryness under reduced pressure. The residue was dissolved in diethyl ether, the solid dicyclohexylurea was filtered off and the ethereal solution was evaporated to dryness. The residue was dissolved in methylene chloride and chromatographed on a silica gel column (344 mm.x 42 mm, Merck K60.;by elution with methylene chloride and then with a 1:1 v/v mixture of methylene chloride and ethyl acetate. There was thus obtained, as an oil, N-[(R,S)-5-acetamido-(R,S) 2-methyl-4-oxo-6-phenylhexanoyl]-L-proline t-butyl ester (Compound No. 1), the structure of which was confirmed by elemental analysis (C,H and N), by proton magnetic resonance spectroscopy and by mass spectroscopy. Elemental Analysis Found: C, 64.9%; H, 8.0; N, 5.8%. C24H34N205.H20 requires C, 64.4%; H, 8.05%; N, 6.2%. Proton Magnetic Resonance Spectrum (in CDC13) EMI18.1 EMI18.2 <tb> Shift <SEP> (#) <SEP> <SEP> Type <SEP> of <SEP> Peak <SEP> No. <SEP> of <SEP> H <SEP> Atoms <SEP> Specific <SEP> H <SEP> atoms <tb> <SEP> 1.15 <SEP> t <SEP> <SEP> 3 <SEP> <tb> <SEP> 1.45 <SEP> 5 <SEP> 9 <tb> <SEP> 1.95 <SEP> d <SEP> 3 <SEP> 0 <tb> 1.70-2.3 <SEP> m <SEP> 6 <SEP> 4 <SEP> ,10,11 <SEP> <tb> <SEP> 3.0 <SEP> m <SEP> 3 <SEP> 6, <SEP> 7 <SEP> <tb> <SEP> 3.60 <SEP> m <SEP> 2 <SEP> <SEP> 0 <SEP> <tb> <SEP> 4.31 <SEP> m <SEP> 1 <SEP> 3 <SEP> <tb> <SEP> 4.70 <SEP> m <SEP> 1 <SEP> 12 <SEP> <tb> 6.25/6.55/6.68 <SEP> m <SEP> 1 <tb> <SEP> 7.20 <SEP> s <SEP> 5 <SEP> 0 <tb> Masa Spectrum (.70 evl Mass No. Ion 431 M+ + 1 430 C24H34N205(M+) 374 M - C4H8 357 M - C4HgO 329 N - COOC(CH3)3 268 M- CH3CONHCH(CH2C6E5) 260 M - Proline t-butyl ester 260 M - CH3CONH The (R,S)-5-acetamido-(R,S)-2-methyl-4-oxo6-phenylhexanoic acid used as starting material was prepared as follows: A solution of 3-methoxycarbonylbutyric acid (29.2 g.; J.Org.Chem., 1972, 37, 555) and oxalyl chloride (31.5 g.) in benzene (100 ml.) was stirred at laboratory temperature for 4 hours, evaporated to dryness under reduced pressure and then twice re-evaporated to dryness from an excess of methylene chloride. A solution of the 3-methoxycarbonylbutyryl chloride thus obtained (20 g.) in dry tetrahydrofuran (40 ml.) was added dropwise during 15 minutes to a stirred solution of freshly distilled 4-benzyl-2-methyloxazol-5(4H)-one (17.7g.; prepared from phenylalanine and acetic anhydride as described in Annalen, 1926, 449, 277), 4-dimethylaminopyridine (0.7 g.) and triethylamine (27 ml.) in dry tetrahydrofuran (100 ml.) which had been cooled to -500C., at such a rate that the temperature of the mixture did not exceed -30 C. The stirred mixture was allowed to warm up to laboratory temperature during 4 hours and was then stirred at laboratory temperature for 70 hours, Acetic acid (30 ml.) was added and the mixture was allowed to stand at laboratory temperature for 1 hour and then evaporated to dryness. The residue was partitioned between ethyl acetate (500 ml.) and aqueous 2N-hydrochloric acid (200 ml.), and the ethyl acetate layer was washed successively twice with aqueous 2Nhydrochloric acid, three times wth 10% w/v aqueous sodium carbonate solution and once with saturated aqueous sodium chloride solution, filtered through anhydrous sodium sulphate and evaporated to dryness under reduced pressure. The residue was purified by chromatography on a 30 cm. x 5 cm. silica gel column using a 1:1 v/v mixture of ethyl acetate and methylene chloride as eluant, and there was thus obtained methyl (R,S)-5acetamido-(R,S)-2- methyl-4-oxo-6-phenylhexanoate (24.75 g.). A mixture of the above ester (12.6 g.) and aqueous 2N-sodium hydroxide solution (100 ml.) was kept at laboratory temperature for 4 hours, washed twice with diethyl ether and then acidified with aqueous 2Nhydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated aqueous sodium chloride solution, filtered through anhydrous sodium sulphate and evaporated to dryness under reduced pressure. The residue was crystallised from a mixture of ethyl acetate and ether and there was thus obtained (R,S)-5-acetamido-(R,S)-2-methyl-4-oxo-ó-phenylhexanoic acid, m.p. 115-1270C. Example 2 The process described in Example 1 was repeated except that the appropriate 4-oxo-5-phenylhexanoic acid and the appropriate L-proline ester were used as starting materials. There were thus obtained the compounds described in the following table: EMI21.1 EMI21.2 <tb> <SEP> R1 <SEP> H <SEP> -R7 <SEP> 0 <SEP> Compound <SEP> No <tb> methyl <SEP> methyl <SEP> methyl <SEP> 2 <tb> methyl <SEP> H <SEP> methyl <SEP> 3 <tb> methyl <SEP> benzyl <SEP> methyl <SEP> (more <SEP> polar <SEP> 4 <tb> <SEP> isomer) <tb> methyl <SEP> benzyl <SEP> methyl <SEP> (less <SEP> polar <SEP> 5 <tb> <SEP> isomer) <tb> phenyl <SEP> methyl <SEP> t-butyl <SEP> 6 <tb> phenyl <SEP> H <SEP> t-butyl <SEP> 7 <tb> benzyl <SEP> methyl <SEP> t-butyl <SEP> (more <SEP> polar <SEP> 8 <tb> <SEP> isomer) <tb> benzyl <SEP> methyl <SEP> t-butyl <SEP> (less <SEP> polar <SEP> 9 <tb> <SEP> isomer) <tb> benzyl <SEP> H <SEP> t-butyl <SEP> 10 <tb> benzamidomethyl <SEP> H <SEP> t-butyl <SEP> 11 <tb> cyclopentanecarbon- <SEP> methyl <SEP> t-butyl <SEP> 12 <tb> amidomethyl <tb> cyclopentanecarbon- <SEP> H <SEP> t-butyl <SEP> 13 <tb> amidomethyl <tb> n-tridecyl <SEP> methyl <SEP> t-butyl <SEP> 14 <tb> The isomeric Compounds Nos 4 and 5, and Compounds Nos. 8 and 9, were separated from each other by the final chromatography step. The structures of all the compounds were confirmed by elemental analysis, proton magnetic resonance spectroscopy and also (in the case of Compounds Nos 2,3,4,5,6,10,11 and 13) by mass spectroscopy, Example 3 The process described in Example 1 was repeated except that L-phenylalanine ethyl ester was used in place of L-proline t-butyl ester. There was thus obtained, as an oil, N- [(R,S)-5-acetamido-(R,S)-2-methyl-4-oxo 6-phenylhexanoyl]-L-phenylalanine ethyl ester (Compound No. 15), the structure of which was confirmed by elemental analysis, proton magnetic resonance spectroscopy and mass spectroscopy. Example 4 The process described in Example 1 was repeated except that (R,S)-5-acetamido-4-oxo-6-phenylhexanoic acid and N-benzylglycine ethyl ester were used as starting materials. There was thus obtained N-[(R,S)-5-acetamido- 4-oxo-6-phenylhexanoyl] -N-benzylgycine ethyl ester (Compound No. 16), the structure of which was confirmed by elemental analysis, proton magnetic resonance spectroscopy and mass spectroscopy. The starting materials (hexanoic acids) used to prepare Compounds Nos. 2 to 14 and 16 described in Examples 2 and 4 were prepared by similar methods to those used to prepare the hexanoic acid described in the second part of Example 1. Particular intermediates used were as follows: (a) 3-ethoxycarbonyl-4-phenylbutyric acid (for Compounds Nos. 4 and 5);monomethyl succinate (for Compounds Nos. 3, 7, 10, 11, 13 and 16). (b) 2,4-dibenzyl -oxazol-5 (4H)-one (for Compounds Nos. 8, 9 and 10);4-benzyl- 2 phenyloxazol-(4H)-one (for Compounds Nos. 6 and 7) (the preparation of the two last-mentioned compounds is described below)° (c) methyl (R,S)-5-benzamido-(R,S)-2-methyl-4-oxo- 6-phenylhexanoate (for Compound No 6);ethyl (R,S)-5phenylacetamido- (R,S)-2-methyl-4-oxo-6-phenylhexanoate (for Compounds Nos 8 and 9),ethyl (R,S)-5-acetamido (R,S)-2-benzyl-4-oxo-6-phenylhexanoate (for Compounds Nos 4 and 5); methyl (R,S)-5-benzamido-4-oxo-6-phenyl- hexanoate (for Compound No. 7);methyl (R,S)-5-acetamido4-oxo-6-phenylhexanoate (for Compounds Nos 3 and 16). The 2,4-dibenzyl-oxazol-5(4E)-one used as an intermediate in the preparation of Compounds Nos. 8 and 9 was prepared by the reaction of (N-phenylacetyl)phenylalanine with dicyclohexylcarbodi-imide, and the 4-benzyl-2-phenyloxazol-5(4H)-one was similarly prepared from (N-benzoyl)phenylalanine. The hexanoic acid starting materials used for the preparation of Compounds Nos. 10 to 14 (and also alternatively for Compounds Nos. 8 and 9) were prepared from the appropriate methyl (R,S)-5-acetamido-4-oxo-6phenylhexanoate, by replacing the 5-acetamido group by the appropriate amido group, as exemp.lified by the following procedure: A mixture of methyl (R,S)-5-acetamido (R,S)-2-methyl-4-oxo-6-phenylhexanoate (10.11 g.) and aqueous 6N-hydrochloric acid (100 ml.) was heated at 1000C. for 6 hours, kept at laboratory temperature for 17 hours and then evaporated to dryness under reduced pressure. Thionyl chloride (5 ml.) was added. during 15 minutes to a stirred, ice-cooled solution of the residue in methanol (100 ml.) and the mixture was stirred at laboratory temperature for 3 hours and then evaporated to dryness under reduced pressure. A mixture of the methyl (R,S)-5-amino-(R,S)-2-methyl-4-oxo-6-phenyl- hexanoate hydrochloride thus obtained (5.7 g.), (.N-cyclopentanecarbonyl)glycine C2.87 g.) and tetrahydrofuran t50 ml.) was stirred and ice-cooled, and N-hydroxybenzotriazole (2.6 g.),triethylamine (10 ml. ) and dicyclohexylcarbodi-imide (4.12 g.) were sequentially added. The mixture was kept at laboratory temperature for 17 hours and filtered, and the filtrate was evaporated to dryness under reduced pressure. The residue was partitioned between ethyl acetate and aqueous 2N-hydrochloric acid, and the ethyl acetate layer was separated, washed successively twice with aqueous 2Nhydrochloric acid, three times with aqueous 10% w/v sodium carbonate solution and once with saturated aqueous sodium chloride solution, filtered through anhydrous sodium sulphate and evaporated to dryness. The residue was stirred with diethyl ether, the solid dicyclohexylurea was filtered off and the ethereal solution was evaporated to dryness. The residue was dissolved in methylene chloride and chromatographed on a silica gel column using a 1:1 v/v mixture of methylene chloride and ethyl acetate as eluant. There was thus obtainedQas an oil, methyl(R,S)-5-(N-cyclopentane- carbonyl)glycinamido- (R,S)-2-methyl-4-oxo-6-phenyl- hexanoate. This ester was then hydrolysed to the hexanoic acid by a similar procedure to that described in the last paragraph of Example 1. There was thus obtained (R,S) 5-(N-cyclopentanecarbonyl)glycinamido-(R,S)-2-methyl- h-oxo-6-phenylhexanoic acid, the structure of which was confirmed by proton magnetic resonance spectroscopy and mass spectroscopy. This compound was used to prepare Compound No. 12. There were similarly obtained the compounds shown in the following table, all of which structures were similarly confirmed: R1-CONH-CH(,CH2C6H5) CoCHR4COOH EMI25.1 <tb> <SEP> R1 <SEP> R4 <SEP> <SEP> Intermediate <SEP> for <tb> <SEP> Compound <SEP> No. <tb> cyclopentanecarbon <SEP> H <SEP> 13 <tb> amidomethyl <tb> benzamidomethyl- <SEP> H <SEP> 11 <tb> benzyl <SEP> methyl <SEP> 8,9 <tb> benzyl <SEP> H <SEP> 10 <tb> tridecyl <SEP> methyl <SEP> 14 <tb> Example 5 A mixture of N-[(R,S)-5-acetamido-(R,S)-2 methyl-4-oxo-6-phenylhexanoyl] -Th-proline t-butyl ester (Example 1, Compound No. 1, 3.04 g.) and a 9:1 v/v mixture of trifluoroacetic acid and water (20 ml.) was stirred at laboratory temperature for 2 hours, evaporated to dryness under reduced pressure and then re-evaporated to dryness from toluene and then from cyclohexane. The residue was dissolved in methylene chloride and chromatographed on silica gel using a 3% v/v solution of methanol in methylene chloride as eluant. There was thus obtained N-[(R,S)-5-acetamido (R,S)-2-methyl-4-oxo-6-phenylhexanoyl]-L-proline. (Compound No. 21), the structure of which was confirmed by proton magnetic resonance spectroscopy and by mass spectroscopy. Proton Magnetic Resonance Spectrum (in CDCl3) EMI26.1 EMI26.2 <tb> Shift <SEP> (6) <SEP> Type <SEP> of <SEP> Peak <SEP> No. <SEP> of <SEP> H <SEP> Atoms <SEP> Specific <tb> <SEP> H <SEP> atoms <tb> 1.08 <SEP> t <SEP> 3 <tb> 1.91 <SEP> m <SEP> <SEP> 3 <SEP> 0 <SEP> <tb> 2.10 <SEP> m <SEP> 5 <SEP> 7 <SEP> ,10 <SEP> ,11 <SEP> <tb> 3.00 <SEP> m <SEP> 4 <SEP> Q <SEP> <tb> 3.62 <SEP> m <SEP> 2 <SEP> 0 <tb> 4.45 <SEP> m <SEP> 1 <SEP> 0 <tb> 4.71 <SEP> t <SEP> 1 <SEP> 12 <SEP> <tb> 6.50 <SEP> t <SEP> 1 <SEP> 2 <tb> 7.20 <SEP> s <SEP> 5 <SEP> 5 <tb> 8.24 <SEP> s <SEP> 1 <SEP> 13 <tb> Mass Spectrum (70 ev) Mass No. Ion 374 C20H26N2O5 (N +) 356 M - H20 330 N - CO2 283 M CH2C6H5 260 M - Proline 212 M - CH3CONHCH(CH2C6H5) 168 (212 - C02) 162 CH3CCNlP+=CHCH2C6H5 A sample of Compound 21 was dissolved in ethyl acetate and a solution of dicyclohexylamine in a mixture of ethyl acetate and ether was added. The mixture was filtered and the solid residue was crystallised from ethyl acetate. There was thus obtained the hemihydrate of the dicyclohexylamine salt of Compound 21, m.p. 191-194 C., the structure of which was confirmed by elemental analysis (Found: C, 68.5%; H, 9.1%; N, 7.2. C32H49N305.21H20 requires: C, 68.1%; H, 8.9; N, 7.4%). Example 6 The process described in Example 5 was repeated using the appropriate ester as starting material. There were thus obtained the compounds described in the follows ing table: EMI27.1 EMI28.1 <tb> Starting <SEP> Material <SEP> R1 <SEP> R4 <SEP> Acid <tb> Compound <SEP> No. <SEP> Compound <SEP> No. <tb> <SEP> 6 <SEP> phenyl <SEP> methyl <SEP> 26 <tb> <SEP> 7 <SEP> phenyl <SEP> H <SEP> 27 <tb> <SEP> 8 <SEP> i <SEP> benzyl <SEP> methyl <SEP> 28 <tb> <SEP> 9 <SEP> benzyl <SEP> methyl <SEP> 29 <tb> <SEP> 10 <SEP> benzyl <SEP> H <SEP> 30 <tb> <SEP> 11 <SEP> benzamidomethyl <SEP> H <SEP> 31 <tb> <SEP> 12 <SEP> cyclopentanecarbon- <SEP> methyl <SEP> 32 <tb> <SEP> amidomethyl <tb> <SEP> 13 <SEP> cyclopentanecarbon- <SEP> H <SEP> 33 <tb> <SEP> amidomethyl <SEP> <tb> The structures of all these compounds were confirmed by proton magnetic resonance spectroscopy. Example 7 A A solution of potassium hydroxide (0.7 g.) in water (10 ml.) was added to a solution of N-[(R,S)- 5-acetamido-4-oxo-6-phenylhexanoyl]-L-proline methyl ester (Example 2, Compound No. 3, 2.15 g.) in ethanol (40 ml.) and the mixture was stirred at laboratory temperature for 1 hour, acidified to pH 4 with aqueous 2N-hydrochloric acid, diluted with saturated aqueous sodium chloride solution and extracted three times with chloroform (15 ml. each time). The combined extracts were washed with saturated aqueous sodium chloride solution and then evaporated to dryness. There was thus obtained N-[(R,S)-5-acetamido-4-oxo-6-phenyl- hexanoyl3-X-proline (Compound No. 23), m.p. 50-600C., the structure of which was confirmed by elemental analysis and proton magnetic resonance spectroscopy. The process described above was repeated using the appropriate methyl or ethyl ester as starting material and there were thus obtained the compounds shown in the following table: R1CONHCH(CH2C6H5)COCH2CHR4CONR5CHR6COOH EMI29.1 <tb> Starting <SEP> arterial <SEP> l <SEP> <SEP> Acid <tb> Compound <SEP> No. <SEP> R1 <SEP> R4 <SEP> R5 <SEP> H6 <SEP> <SEP> Compound <SEP> No. <tb> <SEP> 4 <SEP> methyl <SEP> benzyl <SEP> - <SEP> (CH2)3 <SEP> 24 <tb> <SEP> 5 <SEP> methyl <SEP> benzyl <SEP> -(CH2)3- <SEP> 25 <tb> <SEP> 15 <SEP> methyl <SEP> methyl <SEP> H <SEP> benryl <SEP> 35 <tb> <SEP> 16 <SEP> methyl <SEP> H <SEP> benzyl <SEP> E <SEP> <SEP> 36 <tb> The structures of all these compounds were confirmed by proton magnetic resonance spectroscopy. Example 8 The process described in Example 1 was repeated except that the appropriate (R,S)-5-acylamino-4-oxo-6-phenylhexanoic acid (prepared by a similar process to that described in Example 4 for the preparation of intermediates for Compounds Nos. 10 to 14) and L-proline t-butyl ester were used as starting materials. There were thus obtained, as oils, the compounds described in the following table, the structures of which were all confirmed by elemental analysis, proton magnetic resonance spectrocopy and mass spectroscopy:- EMI30.1 EMI30.2 <tb> <SEP> RÚ <SEP> Compound <SEP> No. <tb> 4-acetamidophenyl <SEP> 17 <tb> 4-methoxyphenyl <SEP> 18 <SEP> <tb> 2-naphthyl <SEP> 19 <SEP> <tb> 8-phenylethyl <SEP> 20 <tb> ss-benzoylethyl <SEP> 41 <tb> y-phenoxypropyl <SEP> 42 <tb> benzyloxy <SEP> 43 <tb> 4-nitrophenyl- <SEP> 278 <tb> 4-chlorophenyl <SEP> 279 <tb> Example 9 N,N'-Dicyclohexylcarbodi-imide (38.3 g.) was added to a stirred solution of (R,S)-5-benzyloxycarbonylamino- 4-oxo-6-phenylhexanoic acid (60 g.), L-proline t-butyl ester (30.5 g.) and N-hydroxybenzotriazole (24 g.) in dry tetrahydrofuran (750 ml.) which was cooled to 0 C., and the mixture was allowed to warm up to laboratory temperature and was then stirred for 18 hours. The mixture was cooled to 0 C and filtered, and the filtrate was evaporated to dryness under reduced pressure. The residue was dissolved in ethyl acetate and the solution was washed successively with aqueous 3% w/v citric acid solution, aqueous 5% w/v sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over sodium sulphate and evaporated to dryness under reduced pressure. The residual oil was purified by chromatography on a silica gel column using a 1:1 v/v mixture of ethyl acetate and methylene chloride as eluant, ant iLere w- > s thas Gbtainds an oil N-[(R,S)-5-benzyloxy- carbonylamino-4-oxo-6-phenylhexanoylj-L-proline t-butyl ester (Compound No. 43). A solution of the above oil, which consists of two isomers (59 g.), in diethyl ether (300 ml.) was kept at laboratory temperatue for 18 hours and then filtered. The solid product was crystallised from a mixture of ethyl acetate and petroleum ether (b.p. 40-600C.) and there was thus obtained one isomer (hereinafter Isomer A) of N-(5-benzyloxycarbonylamino 4-oxo-6-phenylhexanoyl) -L-proline t-butyl ester, m.p. 126-1280C. (Compound No. 43A) The diethyl ether mother liquors from the initial crystallisation were evaporated to dryness under reduced pressure. There was thus obtained as an oil a second isomer (hereinafter Isomer B) of N-(5 benzyloxycarbonylamino-4-oxo-6-phenylhexanoyl) -Th-proline t-butyl ester (Compound No. 43B). The structures of both isomers A and B were confirmed by elemental analysis, proton magnetic resonance spectroscopy and mass spectroscopy. The (R,S) -5-benzyloxycarbonylamino-4-oxo-6- phenylhexanoic acid used as starting material was obtained as follows: A mixture of methyl (R,S)-5-acetamido-4-oxo6-phenylhexanoate (9.5 g; the same intermediate as is described in Example 4 as an intermediate for Compounds Nos. 3 and 16) and aqueous 6N-hydrochloric acid (100 ml.) was heated at 1000C. for 6 hours, cooled and evaporated to dryness under reduced pressure. Toluene (100 ml.) was added and the mixture again evaporated to dryness under reduced pressure. There was thus obtained as oily residue (R,S)-b-amino-4-oxo-6-phenylhexanoic acid hydrochloride. A suspension of sodium bicarbonate (10 g.) in water (50 ml.) was cautiously added to a stirred solution of the above hydrochloride (9.25 g.) in water (100 ml.), and after evolution of carbon dioxide had ceased a solution of benzyl chloroformate (6.1 ml.) in acetone (20 ml.) was added and the mixture was stirred at 50C. for 18 hours. The mixture was washed with diethyl ether (200 ml.) and then acidified to pH 2 with concentrated aqueous hydrochloric acid, and filtered. The solid residue was washed with water (200 ml.) and there was thus obtained (R,S)-5-benzyloxycarbonylamino 4-oxo-6-phenylhexanoic acid, 107-109. Example 10 Potassiumt-butoxide (0.2 g.) was added to a solution of Isomer B of N-(5-benzyloxycarbonylamino-4 oxo-6-phenylhexanoyl)-L-proline t-butyl ester (25 g.) in diethyl ether (200 ml.) and the mixture was kept at laboratory temperature for 5 days and then filtered. The solid residue was crystallised from a mixture of ethyl acetate and petroleum ether (b.p. 40-600C, and there was thus obtained Isomer A of N-(5-benzyloxy carbonylamino-4-oxo-6-phenylhexanoyl) -L-proline t-butyl ester, m.p. 126-128 C. Example 11 A mixture of Isomer A of N-(5-benzyloxycarbonylamino-4-oxo-6-phenylhexanoyl) -L-proline-t-butyl ester (1.0 g.), trifluoroacetic acid (18 ml.) and water (2 ml.) was kept at laboratory temperature for 40 minutes and then evaporated to dryness under reduced pressure. Toluene (30 ml.) was added and the mixture was again evaporated to dryness under reduced pressure, finally at 0.1 mm.Hg. There was thus obtained as oily residue Isomer A of N- (5-benzyloxycarbonylamino-4-oxo-6-phenyl- nexanoyl)-L-proline (Compound No. 143A), the structure of which was confirmed by elemental analysis, proton magnetic resonance spectroscopy and mass spectroscopy. The process described above was repeated using the t-butyl ester Isomer B in place of Isomer A, and there was thus obtained Isomer B of N-(5-benzyloxycarbonyl amino-4-oxo-6-phenylhexanoyl) -Th-proline (Compound No. 143B) Example 12 A 30% palladium-on-charcoal catalyst (o.1 g.) was suspended in a solution of Isomer A of N-(5-benzyloxycarbonylamino-4-oxo-6-phenylhexanoyl)-L-proline (0.9 y.) in a mixture of ethanol (30 ml.) and aqueous N-hydrochloric acid (2.0 ml.), and hydrogen was bubbled through the mixture for 75 minutes. The mixture was filtered and the filtrate was evaporated to dryness under reduced pressure. Toluene (30 ml.) was added and the mixture was again evaporated to dryness under reduced pressure, finally at 0.1 mm/Hg. There was thus obtained, as a foam, Isomer A of N- (5-amino-4-oxo-6-phenylhexanoyl) -L- proline hydrochloride (Compound No. 144A), the structure of which was confirmed by elemental analysis, proton magnetic resonance spectroscopy and mass spectroscopy. The process described above was repeated using the corresponding Isomer B as starting material in place of Isomer A, and there was thus obtained Isomer B of N (5-amino-4-oxo-6-phenylhexanoyl) -L-proline hydrochloride (Compound No 144B), also as a foam. Example 13 Sodium bicarbonate (0.8 g.) was added to a stirred solution of Isomer A of N-(5-amino-4-oxo-6phenylhexanoyl)-L-proline hydrochloride (0.71 g.) in water (30 ml.), and after evolution of carbon dioxide had ceased a solution of p-cyanobenzoyl chloride (0.4g) in acetone (5 ml.) was added and the mixture was stirred at laboratory temperature fcr4 hours and then washed with diethyl ether (30 ml.). The aqueous solution was acidified to pH 3 with aqueous 2N-hydrochloric acid, and then extracted with ethyl acetate (60 ml.). The extract was dried over magnesium sulphate and evaporated to dryness. The solid residue was crystallised from a mixture of ethyl acetate and petroleum ether (b.p. 60-800C.) and there was thus obtained Isomer A of N < 5-E-cyanobenzamido-4-oxo-6-phenylhexanoyl)-L-proline (Compound No. 145A),m.p. 163-1650C. The process described above was repeated using the appropriate acid chloride and either Isomer A or Isomer B of N- (5-amino-4-oxo-6-phenylhexanoyl) -L-proline hydrochloride as starting materials, and where necessary purifying the product obtained by chromatography on a silica gel column using a 2.5% v/v solution of acetic acid in ethyl acetate as eluant. There were thus obtained the compounds described in the following table, all of which were non-crystalline and the structures of which were confirmed by elemental analysis, proton megnetic resonance spectroscopy and mass spectroscopy: EMI34.1 EMI34.2 <tb> <SEP> RÚ <SEP> Isomer <SEP> Compound <SEP> No. <tb> phenyl <SEP> A <SEP> 27A <tb> phenyl <SEP> B <SEP> 27B <tb> 3, <SEP> 4-dichlorophenyl <SEP> A <SEP> 147A <tb> 4-amino-3,5-dichlorophenyl <SEP> A <SEP> 148A <tb> 2-trifluoromethylphenyl <SEP> A <SEP> 149A <tb> 3,4,5-trimethoxyphenyl <SEP> A <SEP> 150A <tb> 4-methylthiophenyl <SEP> B <SEP> 1513 <SEP> <tb> 3,5-dinitrophenyl <SEP> B <SEP> | <SEP> 1523 <SEP> <tb> 2 <SEP> -carboxyphenyl <SEP> B <SEP> 153B <tb> 4-biphenylyl <SEP> B <SEP> i <SEP> 154B <tb> cyclohexyl <SEP> A <SEP> 155A <tb> cyc <SEP> lopropyl <SEP> B <SEP> B <SEP> I <SEP> 156B <SEP> <tb> /continued..... EMI35.1 <tb> <SEP> R1 <SEP> ¯ <SEP> Isomer <SEP> Compound <SEP> No <tb> phenyl-CH=CH- <SEP> B <SEP> 157B <tb> phenyl-CH=CC1- <SEP> A <SEP> 15 <SEP> 8A <tb> <SEP> phenyl-CH=CCl- <SEP> B <SEP> 158B <tb> (phenyl <SEP> ) <SEP> 2CE- <SEP> B <SEP> 159B <tb> <SEP> fF3 <SEP> f <SEP> A <SEP> 160A <tb> phenyl-C1- <SEP> 1 <SEP> B <SEP> Note <SEP> 1 <tb> <SEP> OCH3 <SEP> B <SEP> 60B <tb> Note 1. These two compounds were prepared from (+)2-methoxy-2-phenyl-3,3,3-trifluoropropionic acid (Dale et al., J.Organic Chemistry, 1969, 34, 2543), were purified by chromatography on a silica gel column using a 2% v/v solution of acetic acid in ethyl acetate as eluant, and served to distinguish Isomers A and B. The elemental analysis, 13C and 19F nuclear magnetic resonance spectra and mass spectra of the two isomers were identical, but Isomer A had a larger retention time than Isomer B on high pressure liquid chromatography, and the proton magnetic resonance spectra were different as shown below: EMI35.2 EMI36.1 <tb> -values <SEP> (p.p.m.) <SEP> (No. <SEP> of <SEP> H <SEP> atoms <SEP> and <SEP> type <SEP> of <SEP> peak) <SEP> Specific <SEP> H <SEP> Atoms <SEP> <tb> <SEP> Isomer <SEP> A <SEP> Isomer <SEP> B <tb> 7.40 <SEP> (5H, <SEP> singlet) <SEP> 7.35-7.20 <SEP> (5H, <SEP> multiplet3 <tb> <SEP> # <SEP> 1 <SEP> + <SEP> 2 <SEP> <tb> 7.20 <SEP> (5H, <SEP> singlet) <SEP> 7.15 <SEP> (5H, <SEP> singlet) <tb> 3.19 <SEP> (3H, <SEP> multiplet) <SEP> 3.28 <SEP> (3H, <SEP> multiplet) <SEP> 0 <tb> 2.63 <SEP> (2H, <SEP> multiplet) <SEP> 2.74 <SEP> (2H, <SEP> multiplet) <SEP> <SEP> 0 <SEP> <tb> The proton magnetic resonance spectra showed that Isomer A was uncontaminated by Isomer B, but that Isomer B was sometimes contaminated by a small amount of Isomer A. th8 Frocess described above was repeated using the appropriate acid chloride (or phenyl isocyanate*), and Isomer A of N-(5-amino-4-oxo-6-phenylhexanoyl)-L- proline t-butyl ester (prepared from Compound 43A of Example 9 by hydrogenolysis of the benzyloxycarbonvl group by a similar process to that described in Example 12) as starting materials. There were thus obtained the compounds described in the following table, all of which were non-crystalline and the structures of which were confirmed by elemental analysis, proton magnetic resonance spectroscopy and mass spectroscopy: EMI36.2 EMI37.1 <tb> RÚ <SEP> Compound <SEP> No. <tb> <SEP> phenyl-CH2-CH <SEP> (NHCOOcH2C6H5)-i <SEP> 61A <tb> <SEP> CH3CH(NHCOOCH2C6H5)- <SEP> 62A <tb> <SEP> phenyl-NE- <SEP> * <SEP> 63A <tb> Example Z The process described in the first part of Example 9 was repeated except that (R,S)-5-benzyloxycarbonylamino- (R,S)-2-methyl-4-oxo-6-phenylhexanoic acid was used as starting material in place of the 2-unsubstituted compound. There was thus obtained N-[ (R,S)-5-benzyloxycarbonylamino- (R, S) -2-methyl-4-oxo-6-phenylhexanoyl ]-L-proline t-butyl ester monohydrate (Compound No. 65), the structure of which was confirmed by elemental analysis and infra-red spectroscopy. The hexanoic acid used as starting material was obtained as an oil from methyl (R,S)-5-acetamldo- (R,S)- 2-methyl-4-oxo-6-phenylhexanoate (Example 1) and benzyl chloroformate by a similar procedure to that described in the last part of Example 9. Example 15 The process described in Example 5 was repeated except that N-[(R,S)-5-benzyloxycarbonylamino-(R,S)- 2-methyl-4-oxo-6-phenylhexanoyl]-L-proline t-butyl ester (Compound No 65, Example 14) was used as starting material, and that the product was purified by chromatography on silica gel using a 9:9:1:1 v/v/v/v mixture of ethyl acetate: toluene: formic acid: methanol as eluant. There was thus obtained -I(R,S)-5-benzyloxy- carbonylamino-(R,S)-2-methyl-4-oxo-6-phenylhexanoyla-L- proline (Compound No 165) as an oil, the structure of which was confirmed by elemental analysis and infrared spectroscopy. Example 16 The process described in Example 12 was repeated except that N-[(R,S)-5-benzyloxycarbonylamino-(R,S)- 2-methyl-4-oxo-6-phenylhexanoyl 3 -L-proline (Compound No. 165, Example 15) was used as starting material. There was thus obtained N- [ (R,S) -5-amino- (R,S) -2-methyl- 4-oxo-6-phenylhexanoyl]-l-proline hydrochloride sesquihydrate (Compound No. 166) as a pale yellow solid, the structure of which was confirmed by elemental analysis. Example 17 Thionyl chloride (l5ml.) was added to a stirred solution of N-[ (R,S) -5-amino- (R,S) -2-methyl-4-oxo-6- phenylhexanoyl3-L-proline hydrochloride (5g.) in methanol (50 ml.) which was maintained at -20 C., and the mixture was then stirred for 24 hours, evaporated to dryness and toluene was added and reevaporated until all thionyl chloride had been removed. There was thus obtained as oily residue N-[ (R,S) -5-amino- (R,S)-2- methyl-4-oxo 6-phenylhexanoyl]-L-proline methyl ester (Compound No. 67), the structure of which was confirmed by elemental analysis. Example 18 The process described in Example 13 was repeated except that N-[(R,S)-5-amino-(R,S)-2-methyl-4-oxo-6- phenylhexanoyl]-L-proline hydrochloride (Example 16) or the methyl ester thereof (Example 17) and the appropriate acyl chloride were used as starting materials. There were thus obtained, as oils, the compounds described in the following table, the structures of which were all confirmed by elemental analysis and spectroscopic procedures:- EMI39.1 EMI39.2 <tb> <SEP> R1 <SEP> R7 <SEP> Compound <SEP> No. <tb> 2-tolyl <SEP> H <SEP> 168 <tb> 3-tolyl <SEP> H <SEP> 169 <tb> 4-tolyl <SEP> H <SEP> 170 <tb> 3,5-dimethylphenyl <SEP> H <SEP> 171 <tb> 2-methoxyphenyl <SEP> H <SEP> | <SEP> 172 <tb> 2-methoxyphenyl <SEP> methyl <SEP> 72 <tb> 3-methoxyphenyl <SEP> H <SEP> | <SEP> 173 <tb> 3-methoxyphenyl <SEP> methyl <SEP> 73 <tb> 4-fluorophenyl <SEP> H <SEP> 174 <tb> 2,6-difluorophenyl <SEP> H <SEP> 8 <SEP> 175 <tb> 3-iodophenyl <SEP> H <SEP> 176 <tb> 3-iodophenyl <SEP> methyl <SEP> 76 <SEP> (Note <SEP> 1) <tb> 4-acetylphenyl <SEP> H <SEP> 177 <tb> 4-methanesulphonylphenyl <SEP> H <SEP> 178 <tb> phenoxymethyl <SEP> H <SEP> 179 <tb> phenylthiomethyl <SEP> H <SEP> 180 <tb> Continued.... Continuation.... EMI40.1 <tb> <SEP> R1 <SEP> R7 <SEP> Compound <SEP> No. <tb> <SEP> &beta;-phenylethyl <SEP> H <SEP> 181 <tb> phenoxy <SEP> H <SEP> 182 <tb> p-hydroxyphenyl <SEP> H <SEP> 183 <SEP> (Note <SEP> 2) <tb> Note 1 The methyl ester was prepared by the reaction of the corresponding acid with thionyl chloride and methanol by a similar procedure to that described in Example 17. Note 2 -Acetoxybenzoyld de 's used as starg material, the acetyl group being removed by shaking the final ethyl acetate solution with dilute aqueous sodium hydroxide solution and then acidifying the aqueous layer and extracting with ethyl acetate. Example 19 N-Methylmorpholine (1.1 g.) and isobutyl chloroformate (0.67 g.) were added to a stirred solution of o-ethoxycarbonylmethylbenzoic acid (1 g.) in tetrahydrofuran (40 ml.) which was cooled to -200C., and the mixture was stirred at that temperature for 30 minutes. A solution of N-[ (R1S) -5-amino- (R,S)-2-methyl-4-oxo-6- phenylhexanoyl]-L-proline methyl ester (0.9 g.) in tetrahydrofuran (6 ml.) was added and the mixture was stirred for 5 hours and then evaporated to dryness. The residue was dissolved in ethyl acetate and the solution was washed successively with aqueous 2Nhydrochloric acid, saturated aqueous sodium bicarbonate solution and water, dried over magnesium sulphate and evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 49.5 : 49.5 : 1 v/v/v mixture of ethyl acetate, petroleum ether (b.p. 60-800C) and formic acid as eluant. There was thus obtained N-[(R,S)-5 o-ethOxycarbonylmethylbenzamido-(R,S)-2-methyl-4-oXo- 6-phenylhexanoyl]-L-proline methyl ester (Compound No. 84), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The process described above was repeated using the appropriate acid in place of o-ethoxycarbonylmethylbenzoic acid, and there were thus obtained the compounds described in the following table: EMI41.1 EMI41.2 <tb> <SEP> R1 <SEP> |compound <SEP> No. <tb> -acetamidophenyl <SEP> 85 <tb> 2- <SEP> (benzyloxycarbonylamino)ethyl* <SEP> 86 <tb> 2-aminoethyl* <SEP> 87 <tb> ethoxy <SEP> 88 <tb> * Derived from L-alanine. The process described above was repeated except that -acetamidobenzoic acid and N-[(R,S)-5amino- (R,S)-2-methyl-4-oxo-6-phenylhexanoyl]-L-proline isopropyl ester (prepared by a similar process to that described in Example 17 except that isopropanol was used in place of methanol) were used as starting materials. There was thus obtained N-[(R,S)-5-p-acetamidobenzamido- (R,S) -2-methyl-4-oxo-6-phenylhexanoyl] -L-proline isopropyl ester (Compound No. 280). The process described above was repeated except that p-acetamidobenzoic acid and N-[(R,S)-5 amino- (R, S) 2methyl-4-oxo-6-phenylhexanoyl -L-proline (Compound No. 166;Example 16) were used as starting materials. There was thus obtained N-[R,S)-5-amino- (R,S)-2-methyl-4-oxo-6-phenylhexanoyl]-L-proline. (Compound No. 185). Example 20 A solution of N,N-dicyclohexylcarbodi-imide in methylene chloride (2 ml.) was added to a stirred solution of (R,S)-5-benzamido-6-E-cyanophenyl-(R,S)- 2-methyl-4-.oxohexanoic acid (0.75 g; and l-hydroxybenzotriazole (0.3 g.) in methylene chloride (7.5 ml.) which was cooled to OOC. under an atmosphere of argon, and the mixture was stirred at laboratory temperature for 1 hour and then recooled to O0C. A solution of L-proline isopropyl ester (0.35 g.) in methylene chloride (2 ml.) was added and the mixture was stirred at laboratory temperature for 16 hours and filtered, and the filtrate was evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 1:1 v/v mixture of ethyl acetate and toluene as eluant, and there was thus obtained as an oil N-[(R,S)-5-benzamido 6-p-cyanophenyl- (R,S)-2-methl!l-4-oxohexanoyl]-l- proline isopropyl ester (Compound No. 89), the structure of which was confirmed by elemental analysis and spectro scopic procedures. The (R,S)-5-benzamido-6-2-cyanophenyl-(R,S)-2- methyl-4-oxohexanoic acid used as starting material was obtained as follows: A solution of 3-methoxycarbonylbutyryl chloride (prepared as described in Example 1 from 32.1 g. of 3methoxycarbonylbutyric acid) in tetrahydrofuran (50 ml.) was added during 5 minutes to a stirred solution of 2phenyloxazol-5 (4H)-one (32 g.) and 4-dimethylaminopyridine (0.5 g.) in tetrahydrofuran (1000 ml.) which was cooled to -30 0C. under an atmosphere of argon, and the mixture was stirred at -300C. for 30 minutes and then poured into vigorously stirred ice-water (200 ml.). The mixture was acidified to pH 3 with aqueous Nhydrochloric acid and filtered, and the solid product was washed with water, dried over phosphorus pentoxide and crystallised from acetone. There was thus obtained 4-(3-methoxycarbonylbutyryl)-2-phenyoxa 151-154 0C. Triethylamine (1 ml.) and P-cyanobenzyl bromide (1.35 g.) were added to a stirred solution of the above oxazolone (2 g.) in dimethylformamide (10 ml.) and the mixture was stirred at laboratory temperature for 16 hours and then poured into aqueous 5 hydrochloric acid (100 ml.). The mixture was extracted 5 times with diethyl ether (25 ml. each time) and the combined extracts were washed twice with saturated aqueous sodium bicarbonate solution (25 ml. each time) and twice with saturated aqueous sodium chloride solution (25 ml. each time), dried over magnesium sulphate and evaporated to dryness. The residue was dissolved in acetic acid (15 ml.) containing 4-dimethylaminopiperidine (0.05 g.) and the mixture was heated under reflux for 4 hours and then evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 4:1 v/v mixture of toluene and ethyl acetate as eluant. There was thus obtained methyl (R,S)-5-benzamido 6-E-cyanophenyl-(R,S)-2-methyl-4-oxohexanoate as an oil. A mixture of the above ester (1.85 g.), methanol (10 ml.) and aqueous 2N-sodium hydroxide solution (8 ml.) was stirred at laboratory temperature for 2 hours, acidified with aqueous 2N-hydrochloric acid and extracted 3 times with ethyl acetate (25 ml. each time). The combined extracts were washed with saturated aqueous sodium chloride solution, dried over magnesium sulphate and evaporated to dryness. There was thus obtained as residue (R,S) -5-benzamido-6-±-cyanophenyl- (R,S)-2- methyl-4-oxohexanoic acid. The IA-proline isopropyl ester used as starting material was obtained as follows: Thionyl chloride (30 ml.) was added to isopropanol (130 ml.) which was cooled to -50 C., the mixture was allowed to warm up to -lO0C and IA-proline (23 g.) was added. The mixture was stirred at laboratory temperature for 16 hours, heated under reflux for 30 minutes and the excess of isopropanol and thionyl chloride were removed by evaporation under reduced pressure followed by azeotropic distillation of toluene. The hydrochloride salt thus obtained (1.3 g.) was added to aqueous 75% w/v sodium carbonate solution (10 ml.) at OOC. and the mixture was extracted 3 times with diethyl ether. The combined extracts were dried over magnesium sulphate and evaporated to dryness and there was thus obtained as residue IA-proline isopropyl ester. Example 21 The process described in Example 20 was repeated using the appropriate (R,S)-5-benzamido- 6-substitutedphenyl-(R,S)-2-methyl-4-oxohexanoic acid (prepared by similar means to those described in Example 20) and the appropriate L-proline ester as starting materials, and there were thus obtained the compounds described in the following table, all of which were oils, the structures of which were confirmed by elemental analysis and spectroscope procedures EMI46.1 EMI46.2 <tb> <SEP> R3 <SEP> R7 <SEP> Compound <SEP> No <tb> 4-methylbenzyl <SEP> isopropyl <SEP> 94 <tb> 4-methoxybenzyl <SEP> isopropyl <SEP> 90 <tb> 4-cyanobenzyl <SEP> t-butyl <SEP> 91 <tb> 4-methylbenzyl <SEP> t-butyl <SEP> 92 <tb> 4-methoxybenzyl <SEP> t-butyl <SEP> 93 <tb> 2-chlorobenzyl <SEP> isopropyl <SEP> ! <SEP> 275 <tb> 2-chlorobenzyl <SEP> t-butyl <SEP> 276 <tb> 3-chlorobenzyl <SEP> - <SEP> isopropyl <SEP> 277 <tb> Example 22 The process described in Example 20 was repeated except that (R,S)-5-benzamido-6-E-cyanophenyl4-oxohexanoic acid and IA-proline t-butyl ester were used as starting materials. There was thus obtained, as an oil, N-[(R,S) 5-benzamdo-6-E-cyanophenyl-4-oxo- hexanoyl)-IA-proline t-butyl ester (Compound No. 95). the structure of which was confirmed by elemental analysis and spectroscopic procedures. The (R,S)-5-benzamido-6-p-cyanophenyl-4-oxo- hexanoic acid (m.p. 182-184 C.) used as starting material was obtained by a similar process to that described in the second part of Example 20 except that 3-methoxy carbonylpropionyl chloride was used as initial starting material. Example 23 The process described in Example 20 was repeated using the appropriate (R,S) -5-benzamido-6- substituted-phenyl-4-oxohexanoic acid (prepared by a similar process to that described in the second part of Example 22) and the appropriate IA-proline ester, as starting materials, and there were thus obtained the compounds described in the following table: EMI47.1 EMI47.2 <tb> <SEP> R3 <SEP> R7 <SEP> Compound <SEP> No <tb> <SEP> omp <SEP> . <tb> grmethylbenyzl <SEP> t-butyl <SEP> 207 <tb> E-methylbenzyl <SEP> methyl <SEP> 96 <tb> m-methylbenzyl- <SEP> t-butyl <SEP> 97 <tb> m-methylbenzyl <SEP> methyl <SEP> 98 <tb> o-methylbenzyl <SEP> t-butyl <SEP> 99 <tb> E-chlorobenzyl <SEP> t-butyl <SEP> 100 <tb> ±-fluorobenzyl <SEP> t-butyl <SEP> 201 <tb> p-fluorobenzyl <SEP> methyl <SEP> 202 <tb> o-bromobenzyi <SEP> t-butyl <SEP> 1 <SEP> 203 <tb> 3,4-dichlorobenzyl <SEP> t-butyl <SEP> 204 <tb> p-methoxybenzyl <SEP> t-butyl <SEP> 205 <tb> -nitrobenzyl <SEP> t-butyl <SEP> 206 <tb> benzyl <SEP> benzyl <SEP> - <SEP> 281 <tb> m-cyanobenzyl <SEP> t-butyl <SEP> 208 <tb> ±-trifluoromethylbenzyi <SEP> t-butyl <SEP> 209 <tb> 2-phenylethyl <SEP> t-butyl <SEP> 210 <SEP> Note <SEP> 1 <tb> 3-phenylpropyl <SEP> t-butyl <SEP> 211 <SEP> Note <SEP> 2 <tb> 3-phenylprop-2-enyl <SEP> t-butyl <SEP> 212 <tb> naphth-l-ylmethyl <SEP> t-butyl <SEP> 213 <tb> naphth-2-ylmethyl <SEP> t-butyl <SEP> 214 <tb> --C"Q <SEP> CH, <tb> 7)3 <SEP> I <SEP> t-butyl <SEP> 215 <SEP> Note <SEP> 3 <tb> <SEP> COOC(CH3)3 <SEP> ; <SEP> l <tb> Note 1 The starting material was prepared from 3-methoxycarbonylpropionyl chloride and 4-(2-phenylethyl)2-phenyloxazol-5(4H)-one by a similar method to that described in the second part of Example 1, but including the step of heating with 4-dimethylaminopyridine in acetic acid as described in the third part of Example 20. The 4-(ss-phenylethyl)-2-phenyloxazol-5(4H)-one (m.p. 119 12C.) ) was itself obtained by the reaction of (3-phenyl- ethyl bromide with diethyl acetamidomalonate in the presence of sodium ethoxide, then hydrolysis of the acetamido group with concentrated aqueous hydrochloric acid to give 2-amino-4-phenylbutyric acid hydrochloride; acylation of the amino group with benzoyl chloride in aqueous acetone to give 2-benzamido-4-phenylbutyric acid (m.pL39-141 C); and finally treatment of this acid with N- (3 -dimethylaminopropyl) -N' -ethylcarbodi-imide hydrochloride in methylene chloride solution at 50C. Note 2 The starting material was prepared as described under Note 1 from 4-(3-phenylpropyl)-2-phenyloxazol5(4H)-one, which itself was obtained by hydrogenation of 4- (3-phenyl prop-1-ylidene) -2-phenyloxazol-5 (4H) -one (prepared by a similar process to that described in Chemistry and Industry, 1954, 191) with a 10% palladiumon charcoal catalyst in dioxane solution. The intermediate methyl (R,S)-5-benzamido-4-oxo-8-phenyloctanoat had m.p. 110-112 C. Note 3 The starting material was (R,S)-5-benzamido 6-p-carboxyphenyl-4-oxohexanoic acid, and a second molecule of IA-proline t-butyl ester formed an amide with the E-carboxy group. The process described above was repeated except that (R,S)-5-benzamido-6-E-methoxyphenyl-4- oxchexanoic acid and IA-proline amide were used as starting materials. There were thus obtained two isomers of 1-(5-benzamido-6-Ermethoxyphenyl-4-oxo- hexanoyl)pyrrolidine-(S)-2-carboxamide, a less polar isomer (Compound No. 282A) and a more polar isomer (Compound No. 282B), the isomers being separated by the chromatographic purification step. Example 24 The process described in Example 20 was repeated except that (R, S) -5-N-methylbenzamido-4-oxo- 6-phenylhexanoic acid and L-proline t-butyl ester were used as starting materials. There was thus obtained N-[ (R,S)-5-A-methylbenzamido-4-oxo-6-phenylhexanoyl) - L-proline t-butyl ester (Compound No 216), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The hexanoic acid used as starting material was obtained as follows: Methyl trifluoromethanesulphonate (0.8 ml.) was added to a solution of 4-benzyl-2-phenyl-t-(3- methoxycarbonylpropionyl) -oxazol-5 (4H) -one (1.46 g., m.p.93-94 C.; prepared from 3-methoxycarbonylpropionyl chloride, 2-phenyloxazol-5(4H)-one and benzyl bromide by the general procedure described in the second and third parts of Example 20) in methylene chloride (10 ml.) and the mixture was heated under reflux under an atmosphere of argon for 10 hours and then evaporated to dryness under reduced pressure. The residue was dissolved in a mixture of methylene chloride (21 ml.) and acetic acid (7 ml.), 4-dimethylaminopyridine (0.2 g.) was added and the mixture was heated under reflux for 30 minutes and then evaporated to dryness. The residue was dissolved in methylene chloride and the solution was washed successively with saturated aqueous sodium bicarbonate solution, 10% w/v aqueous hydrochloric acid, water and saturated aqueous sodium chloride solution, dried over sodium sulphate and evaporated to dryness. There was thus obtained (R,S)-5-N-methylbenzamido-4oxo-6-phenylhexanoic acid as an oil which was used without further purification. Example 25 A solution of N-[ (R,S) -5-benzamido-6--nitro- phenyl-4-oxohexanoyl 3 -IA-proline t-butyl ester (Compound No. 206; Example 23; 9.1 g.) in ethanol (350 ml.) was shaken with hydrogen at laboratory temperature and atmospheric pressure for 5 hours in the presence of a 10% palladium-on-charcoal catalyst (0.5 g.). The mixture was filtered, the filtrate was evaporated to dryness and the residue was stirred with diethyl ether. The mixture was filtered and there was thus obtained as solid residue Isomer B of N-6-2-aminophenyl-5- benzamido-4-oxohexanoyl)-L-proline t-butyl ester (Compound No. 217B), m.p. C., (]25 - 3 9 (C=l in D methanol). The ethereal filtrate was evaporated to dryness under high vacuum, and there was thus obtained as an oil Isomer A of N-[6-p-aminophenyl-5-benzamido- 4-oxohexanoyl)-L-proline t-butyl ester (Compound No. 217A) [a)25 -82.60 (C=l in methanol). D Example 26 Acetyl chloride (0.0785 ml.) was added dropwise to a stirred solution of Isomer A of N-(6-E-amino phenyl-5-benzamido-t-oxohexanoyl)-L-proline t-butyl ester (Compound No. 217A; Example 25; 0.493 g.) and triethylamine (0.1384 ml.) in tetrahydrofuran (7 ml.) which was cooled to 0 C under an atmosphere of argon, and the mixture was stirred for 1 hour and then poured onto a silica gel column (10 g.). The column was eluted with a 19:lv/v mixture of methylene chloride and methanol and the appropriate fractions collected and evaporated to dryness. There was thus obtained Isomer A of N-(6-p-acetamidophenyl-5-benzamido-4-oxo- hexanoyl)-IA-proline t-butyl ester (Compound No. 218A), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The process described above was repeated using methanesulphonyl chloride in place of acetyl chloride. There was thus obtained N-(5-benzamido-6 p-methanesulphonamido-4-oxohexanoyl)-L-proline t-butyl ester (Compound No. 219A), the structure of which was confirmed by elemental analysis and spectroscopic procedures. By using trifluoromethanesulphonylchloride there was similarly obtained N-(5-benzamido-6-2-tri- fluoromethanesulphonamido-4-oxohexanoyl)-L-proline t-butyl ester (Compound No. 220A). Example 27 The process described in Example 1 was repeated except that (R,S)-5-p-cyanobenzamido-(R,S)- 2-methyl-4-oxo-6-E-tolylhexanoic acid and IA-proline t-butyl ester were used as starting materials. There was thus obtained as an oil N-[(R,S)-5-E-cyanobenzamido- (R,S3-2-methyl-4-oxo-6-2-tolylhaxanoyl]-L-proline t-butyl ester (Compound No. 221), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The (R,S)-5-E-cyanobenzamido-(R,S)-2-methyl 4-oxo-6-p-tolylhexanoic acid used as starting material was obtained as follows: Diethyl acetamidomalonate (108.sag) was slowly added to a stirred solution of sodium (12 g.) in ethanol (400 ml.) and the mixture was stirred at laboratory temperature for 30 minutes. Sodium iodide (5 g.) and E-methylbenzyl bromide (96 g.) were added and the mixture was stirred and heated under reflux for 16 hours, cooled and evaporated to dryness under reduced pressure. The residue was partitioned between water (250 ml.) and ethyl acetate (500 ml.) and the organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulphate and evaporated to dryness. The residue was stirred with a 4:1 v/v mixture of petroleum ether (b.p. 40-600C) and diethyl ether and the mixture was filtered. There was thus obtained ethyl 2-acetamido-2-ethoxycarbonyl 3-p-tolylpropionate, m.p. 111-113 0C. A stirred suspension of the above diester (127 g.) in 10% aqueous sodium hydroxide solution (600 ml.) was heated under reflux for 4 hours, cooled, acidified with aqueous 3N-hydrochloric acid, reheated under reflux for 1 hour, cooled to 0 0C., kept at that temperature for 72 hours and then filtered. There was thus obtained as solid residue (+)-2-acetamido 3-p-tolylpropionic acid. A mixture of the above acid (35 g.) and acetic anhydride (300 ml.) was stirred at 100C for 40 minutes, cooled and the excess of acetic anhydride was removed by evaporation under reduced pressure. The residue was distilled and there was thus obtained 2-methyl-4 E-tolyloxazol-5 (4H)-one, b.p. 116-120OC/0.2 mm.Hg. This oxazolone was reacted with 3-methoxypentanoylbutyryl chloride by a similar process to that described in the second part of Example 1 to give methyl (R,S) -5-acetamido- (R,S) -2-methyl-4-oxo-E--tolyl- hexanoate, and this was hydrolysed with aqueous 6N hydrochloric acid and acylated with p-cyanobenzoyl chloride by a similar procedure to that described in the last part of Example 9. There was thus obtained (R,S)-5-2-cyano- benzamido-(R,S3-2-methyl-4-oxo-6-p-tolyihexanoic acid which was used without further purification. Example 28 The process described in Example 27 was repeated except the corresponding 5-E-acetamidobenzamido-hexanoìc acid was used as starting material in place of the 5 -cyanobenzamido-hexanoic acid. There was thus obtained as an oil N-[(R,S)-5-2-acetamidobenzamido-(R,S)-methyl- 4-oxo-E-±-tolylhexanoyl]-IA-proline t-butyl ester (Compound No. 222), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The starting material was obtained by a similar procedure to that described in Example 27 except that the final acylation stage was carried out as follows: N-Methylmorpholine (0.77 ml.) and isobutyl chloroformate (0.91 ml.) were added to a stirred solution of -acetamidobenzoic acid (1.25 g.) in tetrahydrofuran (40 ml.) which was cooled to -200C. under an atmosphere of argon, and the stirred mixture was allowed to warm up to laboratory temperature during 1 hour and was then cooled to OOC. (R,S) -5-Amino- (R,S) -2-methyl-4-oxo- 6-2-tolylhexanoic acid (2 g.) and then triethylamine (1.95 ml.) were added and the mixture was stirred at laboratory temperature for 16 hours, and then filtered, and the filtrate was evaporated to dryness under reduced pressure. The residue was partitioned between ethyl acetate (50 ml.) and aqueous 0.1 N-hydrochloric acid (25 ml.) and the organic phase was dried over magnesium sulphate and evaporated to dryness. The residue was purified by chromatography on a silica gel column using a 10:10:1 v/v/v mixture of toluene, ethyl acetate and acetic acid as eluant, and there was thus obtained (R,S)-5-±-acetamidobenzamido- (R,S)-2-methyl-4-oxo-6-E-tolylhexanoic acid. Example 29 Oxalyl chloride (1.0 ml.) and dimethylformamide (0.25 ml.) were added to a stirred solution of N [ > carboxy-(R,S)-2-methylpropionyl]-L-proline t-butyl ester (2.86 g.) in dry methylene chloride (50 ml.) which was cooled to -7O0C. under an atmosphere of argon, and the mixture was stirred at -700C for 2 hours, then at 0-50C for 2 hours and finally at laboratory temperature for 1 hour, and then evaporated to dryness under reduced pressure. Toluene was added and the mixture was evaporated to dryness under reduced pressure. A solution of the acid chloride thus obtained in dry tetrahydrofuran (2 ml.) was added to a stirred solution of 2-phenyloxazol-5(4E)-one (1.47 g.)14-dimethylaminopyridine (0.08 g.) and triethylamine (2.54 ml.) in dry tetrahydrofuran (20 ml.) which was cooled to -400C under an atmosphere of argon, at such a rate that the temperature of the mixture did not exceed -350C. The mixture was stirred at -350C. for 1 hour, then at laboratory temperature for 16 hours, benzyl bromide (1.19 ml.) was added and the mixture was stirred at laboratory temperature for 48 hours. Saturated aqueous sodium carbonate solution (4 ml.) was added and the mixture was stirred at laboratory temperature for 2 hours and then neutralised to pH 7 with aqueous 2N-hydrochloric acid. The organic solvents were removed by evaporation under reduced pressure and the aqueous residue was extracted 4 times with ethyl acetate (50 ml. each time). The combined extracts were washed successively twice with saturated aqueous oxalic acid solution (50 ml. each time), twice with saturated aqueous sodium bicarbonate solution (50 ml.each time) and once with saturated aqueous sodium chloride solution, dried over magnesium sulphate and evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 3:1 v/v mixture of methylene chloride and ethyl acetate as eluant. There was thus obtained, as a foam, N-[(R,S) 5-benzamido-(R,S)-2-methyl-4-oxo-6-phenylhexanoyl3- IA-proline t-butylester (Compound No. 6), identical with that hereinbefore described in Example 2. The N-[3-carboxy- (R,S) -2-methylpropionyl]-IA- proline t-butyl ester used as starting material was obtained as follows: A solution of dicyclohexylcarbodi-imide (4.8 g.) in methylene chloride (100 ml.) was added during 30 minutes to a stirred suspension of N-hydroxybenzotriazole (40.5 g.) and 3-methoxycarbonyl- (R,S) -2-methylpropionic acid (43.8 g.) in methylene chloride (1000 ml,) which was cooled to OOC. under an atmosphere of argon, and the mixture was then stirred at laboratory temperature for 1 hour and recooled to OOC. A solution of L-proline t-butyl ester (51.3 g.) in methylene chloride (100 ml.) was added and the mixture was stirred at laboratory temperature for 16 hours and then filtered. The filtrate was evaporated to dryness, the residue was dissolved in diethyl ether (500 ml.) and the mixture was filtered. The filtrate was washed successively five times with aqueous 2N-hydrochloric acid (50 ml. each time) four times with saturated aqueous sodium carbonate solution (100 ml. each time) and twice with saturated aqueous sodium chloride solution, dried over magnesium sulphate and evaporated to dryness under reduced pressure. Aqueous 2N-sodium hydroxide solution (113 ml.) was added to a solution of the methyl ester thus obtained (61.8 g.) in methanol (325 ml.) and the mixture was stirred at laboratory temperature for 3.5 hours, neutralised with aqueous N-hydrochloric acid and the methanol was removed by evaporation under reduced pressure. Saturated aqueous sodium carbonate solution was added to the aqueous residue and the mixture was washed 3 times with diethyl ether (50 ml. each time). The aqueous solution was then acidified to pH 2 with aqueous N-hydrochloric acid and extracted 6 times with ethyl acetate (50 ml. each time). The combined extracts were washed twice with saturated aqueous sodium chloride solution (50 ml. each time), dried over magnesium sulphate and evaporated to dryness under reduced pressure. There was thus obtained N-[3 carboxy-(R,S)-2-methylpropionyl]-L-proline t-butyl ester as an oil which was used without further purification. Example 30 The process described in Example 29 was repeated except that the ¯ appropriate bromide was used in place of benzyl bromide. There were thus obtained as foams, the compounds described in the following table, the structures of which were all confirmed by elemental analysis and proton magnetic resonance spectroscopy: EMI57.1 EMI57.2 <tb> <SEP> R <SEP> Compound <SEP> No. <tb> p-methylbenzyl <SEP> 92 <tb> m-methylbenzyl <SEP> 223 <tb> -chlorobenzyl <SEP> 224 <SEP> <tb> m-chlorobenzyl <SEP> 225 <tb> -methoxybenzyl <SEP> 93 <tb> -nitrobenzyl <SEP> 226 <tb> ±-trifluoromethylbenzyl <SEP> 227 <tb> ±-cyanobenzyl <SEP> 91 <tb> 4-biphenylmethyl <SEP> 228 <tb> p-t-butylbenzyl <SEP> 229 <tb> 3-phenylprop-2-enyl <SEP> 230 <tb> prop-2-enyl <SEP> 231 <tb> 2-methylprop-2-enyl <SEP> 232 <tb> Example 31 A suspension of a 10% palladium-on-charcoal catalyst (0.03 g.) in a solution of N-[(R,S)-5benzamido-(R,S)-2-methyl-4-oxo-8-phenylocta-7-enoyl]- IA-proline t-butyl ester (Compound No. 230; 0.94 g.) in ethyl acetate (10 ml.) was stirred in an atmosphere of hydrogen for 1 hour and then filtered. The filtrate was evaporated to dryness under reduced pressure and there was thus obtained N-[(R,S)-5-benzamido-(R,S)- 2-methyl-4-oxo-8-phenyloctanoyl] -IA-proline t-butyl ester (Compound No. 2333. The process described above was repeated using N-[(R,S)-5-benzamido-(R,S)-2-methyl-4-oxo-octa- 7-enoyl3-L-proline t-butyl ester (Compound No. 231) or N-t(R,S)-5-benzamidoiR,S)-2,7-dimethyl-4-oxo-octa- 7-enoyl]-L-proline t-butyl ester (Compound No. 232) as starting material, and there was thus obtained, respectively, N-[(R,S)-5-benzamido-(R,S)-2-methyl- 4-oxo-octanoyl]-L-proline t-butyl ester (Compound No. 234) or N-[(R,S)-5-benzamido-(R,S)-2,7-dimethyl-4-oxo octanoyl]-L-proline t-butyl ester (Compound No. 235). All three compounds described above are noncrystalline foams the structures of which were confirmed by elemental analysis and spectroscopic procedures. Example 32 The process described in Example 5 was repeated using the t-butyl esters described in Examples 8, 21, 22, 23, 24, 25, 26, 27, 28, 30 and 31 as starting materials,and there were thus obtained the acids described in the following table, all of which were oils the structures of which were confirmed by elemental analysis and spectroscopic procedures: EMI58.1 EMI58.2 <tb> Starting <SEP> R1 <SEP> <SEP> R3 <SEP> R4 <SEP> <SEP> Acid <tb> Material <SEP> Compound <SEP> <tb> Catound <SEP> No. <tb> No. <SEP> <tb> <SEP> 17 <SEP> 4-acetamidophenyl <SEP> benzyl <SEP> H <SEP> 37 <tb> <SEP> 18 <SEP> 4-methoxyphenyl <SEP> benzyl <SEP> H <SEP> 38 <tb> <SEP> 19 <SEP> 2-naphthyl <SEP> benzyl <SEP> H <SEP> 39 <tb> <SEP> 20 <SEP> ss-phenylethyl <SEP> benzyl <SEP> H <SEP> 40 <tb> <SEP> 41 <SEP> : <SEP> ss-benzoylethyl <SEP> benzyl <SEP> H <SEP> 141 <tb> <SEP> 43 <SEP> benzyloxy <SEP> henzyl <SEP> H <SEP> 143 <tb> <SEP> 91 <SEP> phenyl <SEP> p-cyanobenzyl <SEP> methyl <SEP> 191 <tb> <SEP> 92 <SEP> phenyl <SEP> p-methylbenzyl <SEP> methyl <SEP> 192 <tb> COntinUed... Continuation... EMI59.1 <tb> <SEP> Starting <SEP> R1 <SEP> R3 <SEP> d <tb> <SEP> R' <SEP> Acid <tb> iterial <SEP> Canpound <tb> <SEP> 93 <SEP> phenyl <SEP> Epmethoxybenzyl <SEP> methyl <SEP> 193 <tb> <SEP> 95 <SEP> phenyl <SEP> Ercyanobenzyl <SEP> H <SEP> 195 <tb> <SEP> 97 <SEP> phenyl <SEP> m-methylbenzyl <SEP> H <SEP> 197 <tb> <SEP> 99 <SEP> phenyl <SEP> oathylbenzyl <SEP> H <SEP> 199 <tb> <SEP> 100 <SEP> phenyl <SEP> E <SEP> chlorobenzyl <SEP> H <SEP> 200 <tb> <SEP> 201 <SEP> phenyl <SEP> E <SEP> fluorokenzyl <SEP> H <SEP> 301 <tb> <SEP> 203 <SEP> phenyl <SEP> o-bratbenzyl <SEP> H <SEP> 303 <tb> <SEP> 204 <SEP> phenyl <SEP> 3, <SEP> 4-dichlorobenzyl <SEP> H <SEP> 304 <tb> <SEP> 205 <SEP> phenyl <SEP> methoxybenzyl <SEP> H <SEP> 305 <tb> <SEP> 206 <SEP> phenyl <SEP> p-nitrobenzyl <SEP> H <SEP> 306 <tb> <SEP> 207 <SEP> phenyl <SEP> emethylhenzyl <SEP> H <SEP> 307 <tb> <SEP> 208 <SEP> phenyl <SEP> m-cyanobenzyl <SEP> H <SEP> 308 <tb> <SEP> 209 <SEP> phenyl <SEP> trif1uoranethy1- <SEP> H <SEP> 309 <tb> <SEP> beneyl <tb> <SEP> 210 <SEP> phenyl <SEP> S-phenylethyl <SEP> H <SEP> 310 <tb> <SEP> 211 <SEP> phenyl <SEP> 3-phenylpropyl <SEP> H <SEP> 311 <tb> <SEP> 212 <SEP> phenyl <SEP> 3-phenylprop-2-enyl <SEP> H <SEP> 312 <tb> <SEP> 213 <SEP> phenyl <SEP> naphth-l-ylmethyi <SEP> H <SEP> 313 <tb> <SEP> 214 <SEP> 1 <SEP> phenyl <SEP> naphth-2-yXmethyl <SEP> H <SEP> 314 <tb> <SEP> 215 <SEP> phenyl <SEP> CH2 <SEP> e <SEP> CON <SEP> ss <SEP> H <SEP> 315 <tb> <SEP> COOH <tb> <SEP> 216 <SEP> phenyl <SEP> beneyl <SEP> H <SEP> 316 <tb> <SEP> aN <SEP> methyl) <SEP> l <tb> <SEP> 217 <SEP> phenyl <SEP> E <SEP> E-aminobenzyl <SEP> H <SEP> 317 <tb> <SEP> 217A <SEP> phenyl <SEP> p-aminokenzyl <SEP> H <SEP> 317A <tb> (Isomer <SEP> A) <tb> <SEP> 218A <tb> (Isomer <SEP> A) <SEP> phenyl <SEP> p-acetarnidobenzyl <SEP> / <SEP> H <SEP> 318A <tb> Continued... EMI60.1 <tb> Starting <SEP> R1 <SEP> R3 <SEP> R4 <SEP> Acid <tb> Material <SEP> Compound <SEP> <tb> Canpound <SEP> No. <tb> No. <SEP> <tb> 219A <SEP> phenyl <SEP> p-methanesulphonamido- <SEP> H <SEP> 319A <tb> (Isomer <SEP> A <SEP> benzyl <SEP> <tb> 220A <SEP> phenyl <SEP> p-trifluoromethane- <SEP> H <SEP> 320A <tb> <SEP> sulphonamidobenzyl <SEP> <tb> 221 <SEP> p- <SEP> cyanophenyl <SEP> p-methylbenzyl <SEP> methyl <SEP> 321 <tb> 222 <SEP> p-acetamidophenyl <SEP> p-methylbenzyl <SEP> methyl <SEP> 322 <SEP> <tb> 223 <SEP> phenyl <SEP> m-methylbenzyl <SEP> methyl <SEP> 323 <tb> 224 <SEP> phenyl <SEP> p-chlorobenzyl <SEP> methyl <SEP> 324 <tb> 225 <SEP> phenyl <SEP> m-chlorobenzyl <SEP> methyl <SEP> 325 <tb> 226 <SEP> phenyl <SEP> p-nitrobenzyl <SEP> methyl <SEP> 326 <tb> 227 <SEP> phenyl <SEP> p-trifluoromethyl- <SEP> methyl <SEP> 327 <tb> <SEP> benzyl <tb> 228 <SEP> phenyl <SEP> 4-biphenylmethyl <SEP> methyl <SEP> 328 <tb> 229 <SEP> phenyl <SEP> p-t-butylbenzyl <SEP> methyl <SEP> 329 <tb> 230 <SEP> phenyl <SEP> 3-phenylprop-2-enyl <SEP> methyl <SEP> 330 <tb> 231 <SEP> phenyl <SEP> prop-2-enyl <SEP> methyl <SEP> 331 <tb> 232 <SEP> phenyl <SEP> 2-methylprop-2-enyl <SEP> methyl <SEP> 332 <tb> 233 <SEP> phenyl <SEP> 3-phenylpropyl <SEP> methyl <SEP> 333 <tb> 234 <SEP> phenyl <SEP> n-propyl <SEP> methyl <SEP> 334 <tb> 235 <SEP> phenyl <SEP> isobutyl <SEP> methyl <SEP> 335 <tb> 276 <SEP> phenyl <SEP> o-chlorobenzyl <SEP> methyl <SEP> 376 <tb> 61A <SEP> phenyl-CH2- <SEP> beneyl <SEP> H <SEP> ; <SEP> 161A <tb> <SEP> CH(NHCOOOCH2C6H5)- <SEP> <tb> 62A <SEP> CH3CE(NHCO- <SEP> benzyl <SEP> H <SEP> 162A <SEP> <tb> <SEP> 0CH2C6H5 <SEP> )- <SEP> <tb> 63A <SEP> phenyl-NH- <SEP> benzyl <SEP> H <SEP> 163A <tb> (161A) <SEP> phenyl-CH2CH(NH2)- <SEP> beneyl <SEP> H <SEP> 164A* <tb> 278 <SEP> p-nitrophenyl <SEP> benzyl <SEP> H <SEP> 378 <tb> 279 <SEP> p-chlorophenyl <SEP> benzyl <SEP> H <SEP> 379 <tb> * Prepared from Canpound No. 161A by hydrogenolysis of the benzyloxy carbonyl group by a similar process to that described in Example 12. Example 33 N,N'-Dicyclohexylcarbodiimide (0.93 g.) was added to a stirred solution of N-[(R,S)-5-benzamido (R, S) -2-methyl-4-oxo-6-phenylhexanoyl) -IA-proline (Compound No. 26; 2.09 g.), 4-dimethylaminopyridine (0.06 g.) and methanol (2.0 ml.) in tetrahydrofuran (25 ml.) which was cooled to 0 C., and the mixture was stirred at laboratory temperature for i8 hours, recooled to 0 C. and filtered. The filtrate was evaporated to dryness under reduced pressure, the residue was dissolved in methylene chloride and the solution was washed successively with 1% w/v aqueous citric acid solution, water, 1% w/v aqueous sodium bicarbonate solution and water, dried over magnesium sulphate and evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 1:1 v/v miture of methylene chloride and ethyl acetate as eluant. There was thus obtained, as a foam,N-[ (R,S)-5-benzamido-(R,S)-2-methyl- 4-oxo-6-phenylhexanoyl -IA-proline methyl ester (Compound No. 236), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The process described above was repeated except that the appropriate N-acyl-L-proline (Compound No. 26, 27 or 27A), and the appropriate alcohol were used as starting materials. There were thus obtained the compounds described in the following table, the structures of which were all confirmed by elemental analysis and spectroscopic procedures: EMI61.1 EMI62.1 <SEP> R4 <SEP> R7 <SEP> Compound <SEP> No <tb> methyl <SEP> isopropyl <SEP> 237 <tb> methyl <SEP> n-pentyl <SEP> 238 <tb> methyl <SEP> ss-morpholinoethyl <SEP> 239 <tb> methyl <SEP> X-dimethylaminoethyl <SEP> 240 <tb> H(Isomer <SEP> A) <SEP> isopropyl <SEP> 241A <tb> H(Mixed <SEP> Isomers) <SEP> p-chlorophenyl <SEP> 242 <tb> H(Isomer <SEP> A) <SEP> methyl <SEP> 283A <tb> There was also similarly prepared, from N- (R,S) -5-benzamido-4-oxo-6-phenylhexanoyl) -IA-proline (Compound No. 27) and thiophenol, N-[(R,S)-5-benzamido 4-oxo-6-phenylhexanoyl]-L-proline thiophenyl ester (Compound No. 243). Example 34 Chloromethyl pivaloate (0.66 ml.) was added to a solution of N-[(R,S)-5-benzamido-4-oxo-6-phenyl hexanoyl)-IA-proline (Compound No. 27; 0.71 g.) and triethylamine (0.45 ml.) in ethyl acetate (20 ml.) which had been stirred at laboratory temperature for 30 minutes, and the mixture was then heated under reflux for 18 hours and evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 3:1 v/v mixture of methylene chloride and ethyl acetate as eluant. There was thus obtained N-t(R,S)-5-benzamido-4-oxo-6- phenylhexanoyl] -IA-proline pivaloyloxymethyl ester, (Compound No. 244) the structure of which was confirmed by elemental analysis and spectroscopic procedures. Example 35 The process described in Example 1 was repeated using (R,S)-5-benzamido-(R,S)-2-methyl-4-oxo6-phenylhexanoic acid and the appropriate IA-proline derivative as starting materials, and there were thus obtained as foams the compounds described in the following table, the structures of which were all confirmed by elemental analysis and spectroscopic procedures: EMI63.1 EMI63.2 <tb> <SEP> -Q3R10 <SEP> Compound <SEP> No. <tb> -COOCH2C6H5 <SEP> 245 <tb> -CONH2 <SEP> 246 <tb> -CH2OH <SEP> 247 <tb> Example 36 N-[ (R,S) -5-Benzamido- (R,S) -2-methyl-4-oxo- 6-phenylhexanoyl]-L-proline methyl ester (Compound No. 236, Example 33, 0.5 g.3 was dissolved in saturated methanolic ammonia solution (20 ml.) and the mixture was kept at laboratory temperature for 10 days and then evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 19:1 v/v mixture of methylene chloride and methanol as eluant. There was thus obtained as a foam l-[(R,S)-5-benzamido-(R,S)-2-methyl- 4-oxo-6-phenylhexanoyl)-pyrrolidine- (S) -2-carboxamide (Compound No. 246), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The compound was identical to that obtained in Example 35. Example 37 N,N'-Dicyclohexylcarbodi-imide (0.47 g.) was added to a stirred solution of N-[(R,S)-benzamido (R,S)-2-methyl-4-oxo-6-phenylhexanoyl]-L-proline (Compound No. 26; 1.0 g.) l-hydroxybenzotriazole (0.3 g.) and (3-dimethylaminoethylamine (1.0 ml.) which was cooled to OOC, and the mixture was stirred at laboratory temperature for 16 hours, recooled to 0 0C. and filtered. The filtrate was evaporated to dryness under reduced pressure, the residue was dissolved in methylene chloride (100 ml.) and the solution was washed with 1% aqueous sodium bicarbonate solution and then with water, dried over magnesium sulphate and evaporated to dryness under reduced pressure. The residue was purified by chromatography on a silica gel column using a 9:1 v/v mixture of methylene chloride and methanol as eluant, and there was thus obtained, as a foam, 1- (R,S)-benzamido- (R,S)-2-methyl-4-oxo-6-phenylhexanoyl]pyrrolidine-(S)2-(N-&beta;-dimethylaminoethyl)carboxamide (Compound No. 248), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The process described above was repeated except that a 33% w/v solution of ethylamine in ethanol was used in place of 6-dimethylaminoethylamine. There was thus obtained l-[(R,S)-5-benzamido-(R,S)-2-methyl- 4-oxo-E-phenylhexanoyl ] pyrrolidine- (S) -2-N-ethylcarboxamide (Compound No. 249). Example 38 A solution of diazomethane in diethyl ether was added to a solution of N-[(R,S)-5-benzamido-(R,S) 2-methyl-4-oxo-6-phenylhexanoyl) -IA-proline (Compound No. 26; 0.11 g.) in diethyl ether (2 ml.)until the yellow colour persisted. The mixture was then evaporated to dryness by blowing a stream of argon through it, and there was thus obtained as an oil N-[(R,S)-5-benzamido- (R,S) -2-methyl-4-oxo-6-phenylhexanoyl]-IA-proline methyl ester (Compound No. 236), identical to that prepared according to Example 33. The process described above was repeated using the appropriate acid prepared according to Example 32, and there were thus obtained the esters described in the following table: EMI65.1 EMI65.2 <tb> <SEP> R1 <SEP> R3 <SEP> Compound <SEP> No. <tb> phenyl <SEP> 13-phenylprop-2-enyl <SEP> 250 <tb> phenyl <SEP> 3-phenylpropyl <SEP> 251 <tb> -cyanophenyl <SEP> E-methylbenzyl <SEP> 252 <tb> p-acetamido- <SEP> p-metylbenzyl <SEP> 253 <SEP> <tb> phenyl <tb> phenyl <SEP> E-methylbenzyl <SEP> 254 <tb> phenyl <SEP> m-methylbenzyl <SEP> 255 <tb> phenyl <SEP> ±-chlorobenzyl <SEP> 256 <tb> phenyl <SEP> m-chlorobezyl <SEP> 257 <tb> phenyl <SEP> o-chlorobenzyl <SEP> 258 <tb> phenyl <SEP> -cyanobenzyl <SEP> 259 <tb> phenyl <SEP> p-methoxybenzyl <SEP> 260 <tb> phenyl <SEP> -nitrobenzyl <SEP> 261 <tb> phenyl <SEP> p-trifluoromethylphenyl <SEP> 262 <tb> Example 39 Silica gel (Merck Kieselgel 60, 70-230 mesh ASTM: 450 g.) was deactivated with water (50 ml.) ethyl acetate (25 ml.) and toluene (25 ml.) and the mixture was allowed to stand for 16 hours and then packed into a tube of 5 mm. diameter. N-[(R,S)-5-Benzamido-(R,S)-2 methyl-4-oxo-6-phenylhexanoyl]-L-proline t-butyl ester (Compound No. 6; 3 g.) was absorbed onto silica gel (6 g.) and the mixture was placed on top of the column which was then developed with a 1:1 v/v mixture of ethyl acetate and toluene. The column was dried and cut up into bands from which were separately isolated two isomers of the ester (isomeric at the 2-carbon atom of the hexanoyl chain). The less polar isomer (Compound No. 6A) was 10 times more active as an inhibitor of angiotens in converting enzyme than the more polar isomer (Compound No. 6B). The less polar isomer (1.5 g.) was reapplied to a similar column to that described above which consisted of 1500 g. of silica gel and again separate bands of the dried and cut up column yielded two isomers (isomeric at the 5-carbon atom of the hexanoyl chain) The more polar isomer (Compound No, 6C) was 100 times more active as an inhibitor or angiotensin converting enzyme than the less polar isomer (Compound No. 6D). A mixture of a single isomer at the 5-carbon atom (0.2 g.) dissolved in dimethoxyethane (15 ml.) and aqueous 2N-sodium hydroxide solution was kept at laboratory temperature for 36 hours and neutralised with aqueous N-hydrochloric acid. The organic material was isolated by conventional procedures and found to be a mixture of isomers at the 5-carbon atom. These could be separated as described above and thus it is possible to donvert a less active isomer (for example Compound No. 6D) into more active isomer (for example Compound No. 6C). The t-butyl ester Compound No. 6C was converted into the free acid by the process described in Example 5, and there was thus obtained one isomer of N-(5-benzamido-2-methyl-4-oxo-6-phenylhexanoyl)-L-proline (Compound No. 26C.) Example 40 The process described in Example 1 was repeated except that (R,S)-5-benzamido-(R,S)-2-methyl- 4-oxo-6-phenylhexanoic acid and the appropriate amino acid methyl ester were used as starting materials. There were thus obtained the compounds described in the following table, most of which were oils or low-melting solids, all of which were purified by chromatography on silica gel, and the structures of all of which were confirmed by elemental analysis and spectroscopic pro EMI67.1 EMI67.2 <tb> <SEP> R5 <SEP> R6 <SEP> R16 <SEP> Compound <SEP> No. <tb> -(CH2)2- <SEP> H <SEP> 263 <SEP> (Note <SEP> 1) <tb> (CH234 <SEP> H <SEP> 264 <tb> -(CH2)5- <SEP> H <SEP> 265 <tb> <SEP> # <SEP> 266 <SEP> (more <SEP> polar <SEP> isomer) <SEP> # <SEP> (Note <SEP> 2) <tb> -CH2CHOHCH2- <SEP> H <SEP> 6267 <SEP> <SEP> (less <SEP> polar <SEP> isomer) <tb> <SEP> H <SEP> CH3 <SEP> CH3 <SEP> 268 <tb> <SEP> H <SEP> -(CH2)4- <SEP> 269 <SEP> (m.p. <SEP> 121-124 C.) <SEP> <tb> <SEP> H <SEP> Indol- <SEP> H <SEP> 294 <SEP> (Note <SEP> 3) <SEP> <tb> <SEP> 3-yl-methyl <SEP> <tb> Note 1 The amino acid ester used was methyl azetidine (S) -2-carboxylate. Note 2. The amino acid ester used was (R)-4-hydroxy-L- proline methyl ester. Note 3 The amino acid ester used was IA-tryptophan methyl ester. Sample 41 The process described in Example 7 was repeated using the appropriate methyl ester described in Example 40. There were thus obtained the acids shown in the following table: EMI68.1 EMI68.2 <tb> <SEP> R5 <SEP> R6 <SEP> R16 <SEP> Compound <SEP> No. <tb> <SEP> -(CH2)5- <SEP> H <SEP> 365 <tb> H <SEP> CH3 <SEP> CH3 <SEP> 368 <tb> H <SEP> -(CH2)4- <SEP> 369 <SEP> (m.p. <SEP> 157-1580C. <tb> H <SEP> Thdol- <SEP> H <SEP> <SEP> 394 <SEP> <tb> 3-yl-methyl <tb> The structures of all these compounds were confirmed by elemental analysis and spectroscopic procedures. Example 42 A solution of methyl thiazolidine-(S)-4-carboxylate (0.294 g.) and succinic anhydride (0.2 g.) in methylene chloride (2 ml.) was stirred at laboratory temperature for 2 hours, cooled to -3O0C. and oxalyl chloride (0.27 g.) and dimethylformamide (1 drop) were added. The mixture was stirred at -150C for 2 hours. and then evaporated to dryness, the residue was dissolved in tetrahydrofuran (1.5 ml.) and the mixture was added during 5 minutes to a stirred solution of 4-benzyl-2-phenyloxazol-5(4H)one (0.5 g.), 4-dimethylaminopyridine (0.03 g.) and triethylamine (0.56 ml.) in tetrahydrofuran (4 ml.) which was cooled to -5O0C. The mixture was stirred for 2 hours at -4O0C, then 40 hours at laboratory temperature, acetic acid (3 ml.) was added and the mixture was heated under reflux for 3 hours and then evaporated to dryness under reduced pressure. The residue was dissolved in ethyl acetate and the solution was washed successively with water, aqueous 2N-hydrochloric acid, saturated aqueous sodium chloride solution, saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over magnesium sulphate and evaporated to dryness. The residue was purified by chromatography on a silica gel column using a 1:1 v/v mixture of ethyl acetate and toluene as eluant, and there was thus obtained as a foam methyl N-[ (R,S) - 5-benzamido-4-oxo-6-phenylhexanoyl3- thiazolidine-(S)-4-carboxylate, (Compound No. 270) the structure of which was confirmed by elemental analysis and spectroscopic procedures. Example 43 The process described in Example 7 was repeated using Compound No. 270 (Example 42) as starting material. There was thus obtained N-[(R,S)-5-benzamido-4-oxo-6 phenylhexanoyl]thiazolidine < S)-4-carboxylic acid (Compound No. 370). Example 44 N-Methylmorpholine (0.31 g.) was added to a stirred solution of (R,S) -5-benzamido- (R,S) -2-methyl 4-oxo-6-phenylhexanoic acid (1.02 g.)L-homoserine lactone hydrochloride (0.42 g.), N-hydroxybenzotriazole (0.45 g.) and dicyclohexylcarbodi-imide (0.65 g.) in dimethylformamide (8 ml.) which was cooled to OOC., and the mixture was stirred at 100C. for 3 hours and then at laboratory temperature for 16 hours, and then filtered. The filtrate was evaporated to dryness under reduced pressure, the residue was partitioned between ethyl acetate and aqueous 2N-hydrochloric acid and the organic layer was separated, washed successively with aqueous 2N-hydrochloric acid, saturated aqueous sodium carbonate solution (twice) and saturated aqueous sodium chloride solution, dried and evaporated to dryness. The residue was purified by chromatography on a silica gel column using a 19:1 v/v mixture of chloroform and methanol as eluant, and there was thus obtained N-((R,S)-5-benz- amido- (R, S) -2-methyl-4-oxo-6-phenylhexanoyl) -IA-homoserine lactone (Compound No. 271), m.p. 104-1090C. Example 45 Hydroxylamine hydrochloride (1.0 g.) and pyridine (1 ml.) were added to a solution of N-((R,S)-5-benzamido- 4-oxo-6-phenylhexanoyl)-L-proline t-butyl ester (Compound No. 7; 1.0 g.) in ethanol (20 ml.) and the mixture was heated under reflux for 40 minutes and then evaporated to dryness under reduced pressure. The residue was dissolved in ethyl acetate (75 ml.) and the solution was washed successively with 30 ml. each of aqueous 5% hydrochloric acid, water, saturated aqueous sodium bicarbonate solution and saturated sodium chloride solution, dried over sodium sulphate and evaporated to dryness. There was thus obtained as oily residue N [(R,S)-5-benzamido-4-hydroxyimino-6-phenylhexanoyl] proline t-butyl ester (Compound No. 272), the structure of which was confirmed by elemental analysis and spectroscopic procedures. Example 46 The process described in Example 5 was repeated using Compound No. 272 (Example 45) as starting material. There was thus obtained N-((R,S)-5-benzamido-4-hydroxy- imino-6-phenylhexanoyl]-L-proline (Compound No. 372). Example 47 The process described in Example 14 was repeated except that IA-pro line methyl ester was used in place of IA-proline t-butyl ester. There was thus obtained as an oil N-[ (R,S) -5-benzyloxycarbonylamino- (R,S)-2- methyl-4-oxo-6-phenylhexanoyl]-L-proline methyl ester (Compound No. 273), the structure of which was confirmed by elemental analysis and spectroscopic procedures. Example 48 S-Thiobenzoylthioglycollic acid (0.33 g.) was added to a stirred solution of N-[(R,S)-5-amino (R,S)-2-methyl-4-oxo-6-phenylhexanoyl]-L-proline methyl ester (Compound No. 67; Example 17; 0.54 g.) and triethylamine (0.2 ml.) in pyridine (9 ml.) and the mixture was stirred at laboratory temperature for 40 hours and then poured into aqueous 2N-sulphuric acid. The mixture was extracted with ethyl acetate and the extract was washed with dilute aqueous sodium bicarbonate solution, dried over magnesium sulphate and evaporated to dryness. The residue was purified by chromatography on a silica gel column (18 g.) using an 11:8:1 v/v/v mixture of toluene,ethyl acetate and methanol as eluant. There was thus obtained as an oil N-[(R,S3-2-methyl-4-oxo- 6-phenyl- (R, S) -5-thiobenzamidohexanoyl -IA-pro line methyl ester (Compound No. 274), the structure of which was confirmed by elemental analysis and spectroscopic procedures. Example 49 The process described in Example 33 was repeated using Isomer A of N-(5-±-cyanobenzamido-4-oxo E-phenylhexanoyl)-IA-proline (Compound No. 145A, Example 13) and methanol as starting materials, and there was thus obtained as an oil Isomer A of N-(5-2-cyanobenzamido-4- oxo-6-phenylhexanoyl)-L-proline methyl ester (Compound No. 284A), the structure of which was confirmed by elemental analysis and spectroscopic procedures. Example 50 The process described in Example 1 was repeated except that (R,S)-5-benzamido-(R,S)-2-methyl 4-oxo-6-phenylhexanoic acid and the appropriate amino acid ethyl ester were used as starting materials. There were thus obtained the compounds described in the following table, all of which were oils, all of which were purified by chromatography on silica gel, and the structures of all of which were confirmed by elemental analysis and spectroscopic procedures: EMI72.1 EMI72.2 <tb> <SEP> R5 <SEP> R6 <SEP> Compound <SEP> No. <tb> -CH2CH2SCH2- <SEP> 285 <tb> -CH2CH2OCH2- <SEP> 286 <tb> -CH2CH2NCH2- <SEP> 287 <tb> <SEP> CH3 <tb> -CH2CH=CH- <SEP> 288 <SEP> (Note <SEP> 1) <tb> -CH2SCH2- <SEP> 289 <SEP> (Notes <SEP> 1, <SEP> 2) <tb> <SEP> CH3 <SEP> H <SEP> 290 <SEP> (Note <SEP> 2) <tb> Note 1 The L-amino acid ethyl ester was used as starting material. Note 2 A mixed anhydride procedure using isobutyl chloroformate (similar to that described in Example 19) was used instead of dicyclohexylcarbodiimide to couple the acid and the aminoacid ester. Example 51 The process described in Example 45 was repeated except that methoxyamine or benzyloxyamine were used in place of hydroxylamine. There were thus obtained N-[(R,S) 5-benzamido-4-methoxyimino-6-phenylhexanoyl3 -IA-pro line t-butyl ester (Compound No.291) and N-[(R,S)-5-benzamido 4-benzyloxyimino-6-phenylhexanoyl]-L-proline t-butyl ester (Compound No. 292), the structures of which were confirmed by elemental analysis and spectroscopic procedures. Example 52 The process described in Example 46 was repeated using Compounds Nos.291 and 292 (Example 51) as starting materials. There were thus obtained N-[ (R,S)-5-benz- amido-4 -methoxyimino-E-phenylhexanoyl 3-IA-pro line (Compound No. 391) and N-[ (R,S) -5-benzamido-4-benzyloxyimino-6- phenylhexanoyl 3 -IA-proline (Compound No. 392). Example 53 The process described in Example 1 was repeated except that (R,S)-5-benzamido- (R,S) -3-methyl-4-oxo-6- phenylhexanoic acid and IA-pro line t-butyl ester were used as starting materials. There was thus obtained N-[(R,S)-5-benzamido-(R,S)-3-methyl-4-oxo-6-phenylhexanoyl]- L-proline t-butyl ester (Compound No. 293). This compound was converted to the free acid by the process described in Example 5, and there was thus obtained N-[(R,S3-5-benzamido-(R,S)-3-methyl-4-oxo 6-phenylhexanoyl3-L-proline (Compound No. 393). The structures of both ester and acid were confirmed by elemental analysis and spectroscopic procedures. The (R,S) -5-benzamido- (R,S)-3-methyl-4-oxo-E- phenylhexanoic acid used as starting material was obtained by a similar process to that described in the second part of Example 1, using 3-methoxycarbonyl2-methylpropionyl chloride and 4-benzyl-2-phenyloxazol5(4H)-one as starting materials. Example 54 The process described in Example 1 was repeated using 4-oxo-6-phenyl-(R,S)-5-p-toluenesulphonamìdohexanoic acid and IA-proline t-butyl ester as starting materials. There was thus obtained N-[4-oxo-6-phenyl-(R,S)-5-p- toluenesulphonamidohexanoyl -IA-proline t-butyl ester (Compound No. 295). This compound was converted to the free acid by the process described in Example 5, and there was thus obtained N-t4-oxo-6-phenyl-(R,S)-5-E-toluene- sulphonamidohexanoyl1-l-proline (Compound No. 395). The structures of both ester and acid were confirmed by elemental analysis and spectroscopic procedures. The 4-oxo-6-phenyl-(R,S)-5-E-toluenesulphonamidohexanoic acid used as starting material was obtained by a similar process to that described in the last two parts of Example 4, from p-toluene- sulphonyl chloride and methyl (R,S)-5-amino-4-oxo6 -phenylhexanoate. Example 55 Sodium borbhydride (0.14 g.) was added to a solution of N-t(R,S)-5-benzamido-(R,S)-2-methyl-4-oxo- 6-phenylhexanoyl]-L-proline (Compound No. 26; 0.412 g.) in methanol (10 ml.), and after 15 minutes the mixture was poured into water (50 ml.) The methanol was removed by evaporation under reduced pressure, the aqueous residue was acidified to pH 3 with aqueous 2N-hydrochloric acid and the mixture was extracted with ethyl acetate. The extract was washed with water, dried and evaporated to dryness and the residue was purified by chromatography on a silica gel column using an 11.7:1:1 v/v/v/v mixture of toluene: ethyl acetate: formic acid: methanol as eluant. There was thus obtained, as an oil, N-[R,s)-5-benzamido-(R,S)-4-hydroxy-(R,S)-2- methyl-6-phenylhexanoylj-l-proline (Compound No. 396), the structure of which was confirmed by elemental analysis and spectroscopic procedures. The process described above was repeated using N-[(R,S)-5-benzamido-4-oxo-6-phenylhexanoyl3-L-proline (Compound No. 27) as starting material. There was thus obtained N-[(R,S)-5-benzamido-(R,S)-4-hydroxy-6-phenyl- hexanoyl]-L-proline (Compound No. 397.).

Claims: What we claim is: 1. An amide deri-vative of the formula:- R1-Y-NR2-CHR3-X-CHR11-CHR4-CO-NR5-CR6R16-Q-R10 wherein either R1is hydrogen, or alkyl of up to 15 carbon atoms which is unsubstituted, or which bears one substituent selected from amino, benzyloxycarbonylamino, hydroxy, alkoxy, alkylthio and alkoxycarbonyl each of up to 5 carbon, atoms, and alkyl; aryloxy and ,arylthio substituents; or which bears two or three substituents one of which is aryl,another of which is aryl, hydroxy, amino, benzyloxycarbonylamino, trifluoromethyl, aryloxy or alkoxy ,of up to 5 carbon atoms and the third of which, if present, is aryl or trifluoromethyl; or R1 is aryl or, when Y is carbonyl or thiocarbonyl, is aryloxy, alkoxy or arylalkoxy wherein the alkoxy part has up to 5 carbon atoms; or R1 is halogenoalkyi of up to 6 carbon atoms or is alkenyl, halogenoalkenyl or cycloalkyl each of up to 6 carbon atoms which is unsuhstituted or which bears an aryl substituent; ; or R1 is a substituent of the formula R8CONHCHR9- or R8COCH2CHR9- wherein R8 is alkyl or cycloalkyl each of up to 10 carbon atoms, or aryl and R9 is hydrogen, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl, substituent, or R9 is a group other than those stated above such that the compound H2NCHR9COOH would be a common amino acid; wherein R2 ishydrogen,.alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or aryl;. wherein R3 is alkyl or 'alkenyl each of up t6 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R3 is aryl or indolylmethyl; wherein R4 is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent; wherein either R5 is hydrogen or aryl, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R5 is joined together with R6 as defined below; wherein either R6 is hydrogen, aryl or heterocyclic, or, alkyl of up to 5 carbon atoms which is unsubstituted or which bears a hydroxy, aryl or heterocyclic substituent; or R6 and R5 are joined together to form alkylene or alkenylene of 2 to 5 carbon atoms; or an oxa, thia or aza-derivative of said alkylene or alkenylene; or a hydroxy-or oxo-substituted derivative of said alkylene or alkenylene; or R6 and R16, or R6, R16 and R5, or R6 and R are joined together as defined below; wherein R16 is hydrogen or alkyl of up to 5 carbon atoms; or R6 and R16 are joined together to form alkylene of 2 to 5 carbon atoms (that is, to form a spirocycloalkyl group); or R16 together with the first carbon atom of R6 form a double bdnd wherein R6 is otherwise alkyl, or wherein R6 is otherwise substituted alkyl as defined above, or wherein R6 and R5 are otherwise joined together as defined above (that is, so that 16 R6 and R together form alkylidene); ; wherein Q is carbonyl (-CO-) or methylene (-CH2-); and wherein either.R10 is .hydroxy, amino, aryloxy, arylthio, alkoxy, cycloalkoxy, alkylamino, dialkylamino, cyclic amino, hydroxyalkoxy, acyloxyalkoxy, aminoalkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, cyclic aminoalkoxy, aminoalkylamino, alkylaminoalkylamino, dialkylaminoalkylamino, cyclic aminoalkylamino or aryl alkoxy wherein each alkyl or alkoxy has up to 5 carbon atoms and wherein cyclic amino has up to 6 carbon atoms; 10 and 6 or wherein R and R are joined together such that R1O is oxygen t-0-l joined to the terminal carbon atom of R6 when it is alkyl; ; wherein R11 is hydrogen or alkyl of up to 3 carbon atoms; wherein X is carbonyl (-CO-), hydroxymethylene (-CHOH-), thiocarbonyl (-CS-) or oximinomethylene (-C=N-OR wherein R20 is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent); and wherein Y is carbonyl, thiocarbonyl, sulphonyl (-S02-) or amido (-NHCO-); or a salt thereof where appropriate 2. An amide derivative as claimed in claim 1 wherein X, Y and Q are all carbonyl and Rê and RÚÚ are both hydrogen, or a salt thereof. 3. An amide derivative having the formula: EMI78.1 wherein R1 is alkyl of up to 15 carbon atoms which is unsubstituted or which bears an aryl, aryloxy or arylthio substituent, or RÚ is aryl or aryloxy, or RÚ is a substituent of the formula R8CONHCHR9 or R8 9 8 R8COCH2CHR9- wherein R8 is alkyl or cycloalkyl each of up to 10 carbon atoms, or aryl, and R9 is hydrogen, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R9 is a group other than those stated above such that the compound H2NCHR9COOH would be a common amino acid; wherein Y and R2 have the meanings stated in claim 1; wherein R3 is alkyl or alkenyl each of up to 5 carbon atoms which is unsubstituted or which bears an aryl sbstituent, or R3 is aryl or indolylmethyl; wherein X is carbonyl, hydroxymethylene, thiocarbonyl or oximinomethylene EMI79.1 4 wherein R is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent; 5 wherein either R is hydrogen, aryl or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, R6 is hydrogen, alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl or heterocyclic substituent, or R6 is heterocyclic or aryl, and R16 is hydrogen; or R5 and R6 are joined together to form alkylene or alkenylene of 2 to 4 carbon atoms; or an oxa, thia or aza-derivative of said alkylene or alkenylene; or R6, R16 and R5 are joined together such that R16 together with the first carbon atom of R6 form a double bond wherein R6 and R5 are otherwise joined together as defined above; and wherein R7 is hydrogen or alkyl of up to 5 carbon atoms; or a salt thereof. 4. An amide derivative having the formula R1CONH-CHR3 -COR1O " -COR-¯ -C0NR -CHR -COR wherein RÚ is methyl, benzyl, S-phenylethyl, benzyloxy, phenoxymethyl, phenylthiomethyl, phenyl, tolyl, methoxyphenyl, methylthiophenyl, monochlorophenyl, dichlorophenyl, fluorophenyl, iodophenyl, nitrophenyl, cyanophenyl trifluoromethylphenyl, acetamidophenyl, acetylphenyl, methanesulphonylphenyl, biphenylyl, naphthyl, benzamidomethyl, cyclopentanecarbonamidomethyl or &beta;-benzoylethyl; ; R3 is benzyl which is unsubstituted or bears a methyl, t-butyl, methoxy, fluoro, chloro, bromo, nitro, cyano, trifluoromethyl, amino, acetamido, methanesulphonamido, trifluoromethanesulphonamido or phenyl substituent, or R is 3-phenylpropyl or 3-phenylprop-2-enyl; R4 is hydrogen or methyl; R5 is hydrogen or methyl and R6 is hydrogen, benzyl or indol-3-ylmethyl, or R5 and R6 together form trimethylene, tetramethylene, pentamethylene, 2-hydroxytrimethylene, 2-thiatrimethylene, 3-thiatetramethylene, 3-oxatetramethylene, 3-methyl-3-azatetramethylene; and R10 is hydroxy, amino, alkoxy of up to 5 carbon atoms, or ss-dimethylaminoethoxy or ss-morpholinoethoxy; or a salt thereof. 5. An amide derivative having the formula: EMI80.1 wherein R1 is phenyl, ±-acetamidophenyl or p-cyanophenyl, R3 is benzyl, p-methylbenzyl or p-methoxybenzyl, R4 is 10 hydrogen or methyl and R is hydroxy, amino, methoxy, ethoxy, isopropoxy or t-butoxy, or a salt thereof. 6. The compound N-(5-acetamido-2-methyl-4-oxo 6-phenylhexanoyl-L-proline, N-(5-benzamido-2-methyl-4- oxo-6-phenylhexanoyl)-L-proline or N-(5-phenylacetamido2-methyl-4-oxo-6-phenylhexanoyl)-L-proline, or a salt thereof, and or an ester thereof with an alcohol of up to 5 carbon atoms, or an amide thereof. 7. The compound N- ±5-benzamido-2-methyl-4-oxo-6- phenylhexanoyl)-IA-proline, or its methyl ester, or its amide, or a salt thereof. 8. A salt of an amide derivative, claimed in any of claims 1 to 7 wherein R1O is hydroxy which is an alkali metal or alkaline earth metal salt, or an ammonium or dicyclohexylamine salt. 9. A process for the manufacture of an amide derivative or a salt thereof, claimed in any of claims 1 to 8, which comprises (a) the reaction of an acid of the formula:- R1-Y-NR2 -CHR3-X-CHR11 -CHR4-COOH wherein R1, R2, R3, R4, R11, X and Y have the meanings stated in any of claims 1 to 5, or of a reactive derivative thereof, with an amine of the formula: HNR5-CR6R16 -Q-R12 wherein R5, R6, R16 and Q have the meanings stated in 12 any of claims 1 to 5 and wherein R12 has any of the meanings stated in claims 1 to 5 for R10 except those containing a free hydroxy or amino group; or (b) for the manufacture of an amide derivative wherein R2 is hydrogen and X is carbonyl or thiocarbonyl, the reaction of an amine of the formula: H2NCHR3-X1-CHR11CHR4CONR5-CR6R16-Q-R12 wherein R3, R4, R5, R6, R11, R12 R16, Q and X1 have the meanings stated above, with a compound of the formula R1-Y-Z1, wherein R1 and Y have the meanings stated above and wherein ZÚ is a displaceable halogen, alkanesulphonyl or arensulphonyl group, or Z is hydroxy (in which case the reaction is carried out in the presence of a carbodiimide or an alkyl chloroformate), or, when Y is amido, with a compound of the formula R NCO, or, when Y is thiocarbonyl, with a compound of the formula RÚCS-SCH2COOH; or (c) for the manufacture of an amide derivative wherein R2 is hydrogen and X is a carbonyl, the reaction of a compound of the formula: Z2COCHR11CHR4CONR5CR6R16QR12 wherein R4, R5, R6, R11, R12, R16, and Q have the meanings stated above and Zê is a displaceable halogen atom, with a compound of the formula EMI82.1 wherein R1 and R3 have the meanings stated above, followed by hydrolysis of the oxazolone ring; whereafter an amide derivative wherein R2 is alkyl, arylalkyl or aryl (and R10 is R12) may be obtained by reacting the corresponding amide derivative wherein R2 is hydrogen (and R1O is R12) with a compound of the formula R2Z, wherein R2 has the meaning stated above and Z is a displaceable halogen, alkanesulphonyl or arenesulphonyl group; or whereafter an amide derivative wherein R3 is unsubstituted or substituted alkyl may be obtained by the hydrogenation of the corresponding compound wherein R is unsubstituted or substituted alkenyl; or whereafter an amide derivative wherein R10 is other than hydroxy (that is, wherein-Q-R1O forms an ester or amide group) may be obtained from the corresponding acid wherein-O-R10 is -COOH by conventional means of ester or amide formation; or whereafter an amide derivative wherein Q is carbonyl and R10 is hydroxy may be obtained by the hydrolysis of the corresponding amide derivative wherein R10 is alkoxy, or, when R10 is t-butoxy, by the acid-catalysed cleavage of said compound; or whereafter an amide derivative wherein X is hydroxy methylene may be obtained by the reduction of the corresponding amide derivative wherein X is carbonyl; or whereafter an amide derivative wherein X is oximinomethylene may be obtained by the reaction of the corresponding amide derivative wherein X is carbonyl with hydroxylamine or an 0-substituted'hydroxylamine derivative. 10. A pharmaceutical composition comprising as active ingredient at least one amide derivative, or a salt thereof, claimed in any of claims 1 to 8, in association with a pharmaceutically-acceptable diluent or carrier therefor. EMI84.1 EUROPEAN APPLICATION NO. Amides of 4-oxo-5-amidohexanoic acid derivatives Claims for Austria What we cl,aim is: 1. A process for the manufacture of an amide derivative of the formula: R1-Y-NR2-CHR3-X-CHR11-CHR4-CO-NR5-CR6R16-Q-R10 wherein either R1 is hydrogen, or alkyl of up to 15 carbon atoms which is unsubstituted, or which bears one substituent selected from amino, benzyloxycarbonyl- amino, hydroxy, alkoxy, alkylthio and alkoxycarbonyl each of up to 5 carbon atoms, and aryl, aryloxy and arylthio substituents; or which bears two or three substituents one of which is aryl, another of which is aryl, hydroxy, amino, benzyloxycarbonylamino, trifluoromethyl, aryloxy or alkoxy of up to carbon atoms and the third of which, if present, is aryl or trifluoromethyl; or RÚ is aryl or, when Y is carbonyl or thiocarbonyl, is aryloxy, alkoxy or arylalkoxy wherein the alkoxy aprt has up to 5 carbon atoms; or. on R1 is halogenoalkyl of up to 6 carbon atoms or is alkenyl, halogenoalkenyl or cycloalkyl each of up to 6 carbon atoms -which is unsubstituted or which bears an aryl substituent; ; or RÚ is a substituent of the formula R8CONHCHR9- or R8COCH2CHR9) wherein R8 is alkyl or cycloalkyl each 9 of up to 10 carbon atoms, or aryl and R9 is hydrogen, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R9 is a group other than those stated above such that the compound H2NCHR9COOH would be a common amino acid; wherein R2 is hydrogen, alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or aryl; wherein R is alkyl or alkenyl each of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, or R3 is aryl or indolylmethyl; wherein R4 is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent; wherein either Ri is hydrogen or aryl, or alkyl of up to 5 carbon atoms which is'unsubstituted or which bears an aryl substituent, or R5 is -joined together with R6 as defined below; wherein either R6 is hydrogen, aryl or heterocyclic, or alkyl of up to 5 carbon atoms which is unsubstituted or which bears a hydroxy, aryl or heterocyclic substituent; or R6 and R5 are joined together to form alkylene or alkenylene of 2 to 5 carbon atoms; or an oxa, thia or aza-derivative of said alkylene or alkenylene; or a hydroxy- or oxo-substituted derivative of said alkylene or alkenylene; or R6 and R16, or R6, R16 and R5, or R6 and R16 are joined together as defined below; wherein R16 is hydrogen or alkyl of up to 5 carbon atomS; or R6 and R16 are joined together to form alkylene of 2 to 5 carbon atoms (that is, to form a spirocycloalkyl group); R16 òr together with the first carbon atom of R6 form a double bond wherein R6 is otherwise alkyl, or wherein R6 is otherwise substituted alkyl as defined above, or wherein R6 and R5 are. otherwise joined together as defined above (that is, so that R5, R6 and R16 together form alkylidene); wherein Q is carbonyl (-CO-) or methylene (-CH2-); ; and wherein either R10 is hydroxy, amino, aryloxy, arylthi9, alkoxy, cycloalkoxy, alkylamino, dialkylamino, cyclic amino, hydroxyalkoxy, acyloxyalkoxy, aminoalkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, cyclic aminoalkoxy, aminoalkyiamino, alkylaminoalkylamino, dialkylaminoalkylamino, cyclic aminoalkylamino or arylalkoxy wherein each alkyl or alkoxy has up to 5 carbon atoms and wherein cyclic amino'has up to 6 carbpn atoms; or wherein R10 and R6 are joined together such that R10 Is oxygen (-0-) joined to the terminal carbon atom of R6 when it is alkyl,; wherein R11 is hydrogen or alkyl of up to 3 carbon atoms; ; wherein X is carbonyl (-CO-), hydroxymethylene (-CHOH-), thiocarbonyl (-CS-) or oximinomet-hylene (-C=N-OR20 wherein R20 is hydrogen or alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent); and wherein Y is carbonyl, thiocarbonyl, sulphonyl (-SO2-) or amido (-NHCO-); or a salt thereof where appropriate, characterised by either: (a) the reaction of afl acid of the formula: R1-Y-NR2-CHR3-X-CHR11-CHR4-COOH wherein R1, R2, R3, R4, Rll, X and Y have the meanings stated above,.or of a reactive derivative thereof, with an amine of the'formula:- HNR5-CR6R16-Q-R12 wherein R5, R6, R16 and Q have the meanings stated above and wherein R12 has any of the meanings stated above for R10 except those containing a free hydroxy or amino group; or (b) for the manufacture of an. amide derivative wherein R2 is hydrogen and X is carbonyl or thiocarbonyl, the reaction of an amine of the formula: H2,NCHR3-X1-CHR11-CHR4CONR5-CR6R16-Q-R12 wherein R3, R4, R5, R6, R11, R12 R16 and have the meanings statedabove and X1 is carbonyl or thiocarbonyl, with a compound of the formula RÚ-Y-ZÚ, wherein RÚ and Y have the meanings stated above and wherein Z1 is a displaceable halogen, alkanesulphonyl or arensulphonyl group, or Z1 is hydroxy ( in which case the reaction is carried out in the presence of a carbodiimide or an alkyl chloroformate), or, when Y is amido, with a Compound of the formula RNCO,- or, when Y is thiocarbonyl, with-a compound of the formula R1CS-SCH2COOH; or (c) - for the manufacture of an amide derivative wherein R2 is hydrogen and X is a carbonyl, the reaction of a compound of the formula: Z2C0CHR11 CHR490NR5CR6R16 QR12 ,wherein R4, R5, R6, R11,, R12, R16, and Q have the meanings stated above and Z2 is a displaceable halogen atom, with a compound of the formula EMI87.1 wherein R1 and R3 have the meanings stated above, followed by hydrolysis of the oxazolone ring; whereafter an amide derivative wherein R2 is alkyl, arylalkyl or aryl (and R10 is R12) may be obtained by reacting the corresponding amide derivative wherein R2 is hydrogen (and R10 is R12) with a compound of the formula R2 Z, wherein R2 has the meaning stated above and Z is a displaceable halogen, alkanesulphonyl or arenesulphonyl group; or whereafter an amide derivative wherein R3 is unsubstituted or substituted alkyl may be obtained by the hydrogenation of he corresponding compound wherein R3 is unsubstituted or substituted alkenyl; or whereafter an amide derivative wherein R10 is other than hydroxy (that is, wherein -Q-R1O forms an ester or amide group) may be obtained from the corresponding acid wherein -Q-R10 is -COOH by conventional means of ester or amide formation; or whereafter an amide derivative wherein Q is carbonyl and R10 is hydroxy may be obtained by the hydrolysis of the corresponding amide derivative wherein R10 is alkoxy, or, when R10 is t-butoxy, by the acid-catalysed cleavage of said compound; or whereafter an amide derivative wherein X is hydroxymethylene may be obtained by the reduction of the corresponding amide derivative wherein X is carbonyl; or whereafter an amide derivative wherein X i,s' oximino- methylene may be obtained by the reaction of the corresponding amide derivative wherein X is carbonyl with hydroxylamine or an O-substituted hydroxylamine derivative. 2. A process for the manufacture of an amide derivative having the formula: EMI89.1 wherein R1 is alkyl of up t6 15 carbon atoms which is, unsubstituted or which bears an aryl, aryloxy or arylthio substituent, or RÚ is aryl or aryloxy, or R1 is a substituent of the formula R8CONHCHR9- or R8COCH2CHR9- wherein R is alkyl or cycloalkyl each of up to, 10 carbon atoms, or aryl, and R9 is hydrogen, or alkyl of up to 5 carbon atoms which is unsubstituted 9 or which bears an aryl substituent, or R is a group other than those stated above such'that the compound H2NCHR9COOH would be a common amino acid; wherein Y and R2 have the meanings stated in claim 1; wherein R3 is alkyl or alkenyl each of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent; or R3 is aryl or indolylmethyl; wherein X is carbonyl, hydroxymethylene, thiocarbonyl or oximinomethylene ( C=N-OH); wherein R4 is hydrogen or alkyl of up to 5 carbon atoms, which is unsubstituted or which bears an aryl substituent; wherein either R5 is hydrogen, aryl or 'alkyl of up to 5 carbon atoms which is unsubstituted or which bears an aryl substituent, R6 is hydrogen-, alkyl of up to 5 carbon atoms which is unsubstituted or which bears an 6 ary or heterocyclic substituent, or R is heterocyclic or aryl, and R16 is hydrogen; or R5 and R6 are joined together to, form alkylene or alkenylene of 2 to 4 carbon atoms; or an oxa, thia or aza-derivative of said alkylene or alkenylene; or R6, R16 and R5 are joined-togehter such that R16 together with the first carbon atom of R6 form a double bond wherein R6 and R5 are otherwise joined together as defined above; and wherein R7 is hydrogen or alkyl of up to 5 carbon atoms; or a salt thereof, characterised by the reaction of an acid of the formula: R1-Y-NR2-CHR3-X-CH,-CHR4-COOK 2 wherein R1, R2 R3 R4 X and Y have the meanings stated above, or of a reactive derivative thereof with an amine of the formula: EMI90.1 wherein R5 R6 and R16 have the meanings stated above and wherein R12 is alkyl of up to 5 carbon atoms; wl-le-eafter an amide derivative wherein R2 is alkyl, arylalkyl or aryl (and R7 is alkyl) may be obtained by rcacting the corresponding amide derivative wherein R2 xs-hydrogen (and R7 is alkyl) with a compound of the formula R2Z, wherein R2 has the meaning stated above and Z is a displaceable halogen, alkanesulphonyl or arenesulphonyl group; or whereafter an amide derivative wherein R7 is hydrogen may be obtained by the hydrolysis of the corresponding amide derivative wherein R7 is alkyl, or, when R7 is t-butyl, by the acid-catalysed cleavage of said compound; or whereafter an amide derivative wherein X. is hydroxymethylene may be obtained by the reduction of the corresponding amide derivative wherein X is carbonyl; or whereafter an amide deriative wherein X is-oximinomethylene may be obtained by the reaction of the corresponding amide derivative wherein X is carbonyl with hydroxylamine. 3. A process for the manufacture of an amide derivative having the formula: R1CONH-CHR3-COCH2-CHR4-CONR5-CHR6-COR10 wherein R1 is methyl, benzyl, ss-phenylethyl, benzyloxy, phenoxymethyl, phenylthiomethyl, phenyl, tolyl, methoxyphenyl , methylthiophenyi, monochlorophenyl, dichlorophenyl, trifluoromethylphenyl, acetamidophenyl, acetylphenyl, methanesulphonylphenyl, biphenylyl, naphthyl, benzamidomethyl, cyclopentanecarbonamidomethyl or ss-benzoylethyl; R3 is benzyl which is unsubstituted or bears a methyl, t-butyl, methoxy, fluoro, chloro, bromo, nitro, cyano, trifluoromethyl, amino, acetamido, methanesulphonamido, trifluoromethanesulphonamido or phenyl substituent, or R3 is 3-phenylpropyl or 3-phenylprop-2-enyl; R4 is hydrogen or methyl; ; R5 is -hydrogen or methyl and R6 is hydrogen, benzyl or indol-3-ylmethyl, or R5 and R6 together form trimethylene, tetramethylene, pentamethylene, 2-hydroxytrimethylene, 2-thiatrimethylene, 3-thiatetramethylene, 3-oxatetramethylene, 3-methyl-3-"azatetramethylene; and R10 is hydroxy, amino, alkoxy of up to 5 carbon atoms, or -ss-dnmethylaminoethòxy or ss-morpholinoethoxy; or a, salt thereof, characterised by (a) the reaction of an acid of the formula: 4 R1CONH-CHR -COCH2-CHR -COOH wherein R1, R3 and R4 have the meanings stated above, or of a reactive derivative thereof, with an amine'of the formula: :- HNR5-CHR6-COR1 wherein R5 and R6 have the meanings stated above and wherein R12 has any of the meanings stated above for R10 except hydroxy and amino; or (b) the reaction of an amine of the formula: H2NCHR3-COCH2-CHR4-CONR5-CHR6-COR12 wherein R3 R4 R5, R6 and R12 have the meanings stated above, with a compound of the formula RÚ-COZÚ, wherein RÚ has the meaning stated above and wherein Z1 is a displaceable halogen, alkanesulphonyl or are sulphonyl group, or Z1 is hydroxy (in which case the reaction is carried out in the presence of a carbodiimide or an alkyl chloroformate); or (c) the reaction of a compound of the formula: Z2CoCH2CHR4CONR CHR6COR12 wherein R4, R5, R6 and R12 have the meanings stated above and z2 is a displaceable halogen atom, with a compound of the formula: EMI92.1 wherein R1 and R3 have the meanings' stated above, followed by hydrolysis of the oxazolone ring; whereafter an amide derivative wherein R3 is 3-phenyl- propyl may be obtained by the hydrogenation of the corresponding compound wherein R3 is 3-phenylprop-2-enyl; whereafter an amide derivative wherein R1O is hydroxy may be obtained by the hydrolysis of the corresponding amide derivative wherein R10 is alkoxy, or, when R10, is t-butoxy, by the acid-catalysed cleavage of said compound; and whereafter an amide derivative wherein R10 is other than hydroxy (that is, wherein COR10 forms an ester or amide group) may be obtained from the corresponding acid wherein -CO-R10 is -COOH by conventional means of ester or amide formation. 4. A process as claimed in claim 3 wherein in the starting materials R1 is phenyl, p-acetamidophenyl or p-cyanophenyl, R3 is benzyl, p-methylbenzyl or methoxybenzyl, R4 is hydrogen or methyl, R5 and R6 are joined together to form trimethylene and R10 is hydroxy, amino, methoxy,. ethoxy, isopropyl or t-butoxy.

Inventors: GRAVESTOCK, MICHAEL BARRY
Applicants: IMPERIAL CHEMICAL INDUSTRIES PLC
Application year: 1981
Main classification: C07C103
IPC codes: C07K5, C07D223, C07C237, C07D207, C07D263, C07D205, C07D265, C07D211, C07D277, C07D239, C07D209, C07D279