N-SULFINYL CARBAMATES, THEIR USE AS PESTICIDES, PESTICIDAL COMPOSITIONS CONTAINING THEM, METHODS OF PRODUCING THEM AND HALOSULFINYL CARBAMATES FORMED DURING THEIR PRODUCTION

Abstract: N-sulfinyl carbamates having the general formula are novel compounds. They are useful as pesticides, particu­ larly insecticides, and are applied to crops and other loci where pests are to be killed. Pesticidal compositions contain such compounds. The compounds are produced by reacting a carbamate of the formula with an equimolar amount or molar excess of thionyl chloride to produce a compound of formula R²-O-CO-NR³-SOCl, which constitutes another embodiment of the present invention, and reacting the latter with a suitable nucleophilic reactant. In the formula R² is one of certain hydrocarbon and substituted hydrocarbon and imino groups, R³ is C₁₋₄ alkyl, phenyl or one of certain substituted phenyl groups, and R¹ is the residue of certain nucleophilic reactants. The pesticidal compounds of the present invention retain the insecticidal activity of the carbamates from which they are derived but are lower in mammalian toxicity.

Description: K-SULFINYL CARBAMATES, THEIR USE AS PESTICIDES, NATURAL COM POSITIONS CONTAINING THEM, METHODS OF PRODUCING @@@ AND HALO- SULFINYL CARBAMATES FORMED DURING THEIR PRODUCTION The present invention is directed to a new class of carbamate pesticides, to intermediates therefor, to an insecticidal method and composition thereof, and to a process for manufacture. More particularly, the invention is directed to N-sulfinyl carbamates useful as insecticides or insecticide intermediates. Various types of carbamate pesticides have been previously described. For example, U.S. Patent No 3,997,549 to Fukuto and Black discloses N-arylsulfenylated derivatives of benzofuranyl methylcarbamates as effective pesticides; U.S. Patent No. 4,006,231 to Black and Fukuto discloses N-aminosulfenylated derivatives or carbofuran as effective pesticides; and U.S. Patent No. 3,843,689 to Brown discloses production of N-methyl or N-phenyldithiocarbamates produced from N-chlorothiocarbamates, as insecticides. The insecticidal compounds of this invention have a high level of insecticidal activity and improved mammalian toxicity. Activity is generally about egur to that for the carbamate insecticide from which that compound is derived, but mammalian toxicity is general substantially lower. The sulfinylcarbamates of this invention are those having the formula: EMI1.1 in which: RÚ is a halogen atom selected from bromine, chlorine and fluorine, preferably chlorine; EMI1.2 R2 and R7, the same or different, are alkyl of 1 to 8 carbon atoms; naphthyl; phenyl; a substituted aryl group of the formula EMI2.1 or EMI2.2 wherein R is alkyl, alkoxy, alkylthio, alkylthio a alkyl or 2-dioxolanyl, Ab is hydrogen, alkyl, alkoxy, alkoxyalkyl, formyl(alkyl)amino, or halogen (chlorine or bromine), R is hydrogen, alkyl, alkoxy, alkylthio or c dialkylamino, Rd is hydrogen or alkyl, and each alkyl group contains 1 to 6, preferably 1 to 4 carbon atoms; a heterocyclic group of the formula EMI2.3 in which Re and Rf are hydrogen or alkyl of 1 to 4 carbon atoms, A and B are each oxygen or one of A and B is methylene and the other is oxygen or sulfur, attached at the 4 or 7 position, for example, 2,3-dihydro-2, 2-dimethyl-7-benzofuranyl or 2,2-dimethyl-1, 3-benzodioxol-4-yl; or an imino group of the formula RgRC=N wherein Rg is hydrogen or alkyl of 1 to 4 carbon atoms and Rh is alkylthio, alkylthioalkyl or dialkylaminocarbonyl, in which the alkyl groups, the same or different, have 1 to 4 carbon atoms; R3 F R6 and R8, the same or different Sre ally1 of 1 to 4 carbon atoms or phenyl optionally substituted with alkyl or halogen; R4 and R5 are alkyl of 1 to 12 carbon atoms, preferably 3 to 10 carbon atoms; unsaturated aliphatic hydrocarbon of 2 to 4 cartoon atoms; or phenyl optionally substituted with alkyl of 1 to 6 carbon atoms, alkylthio of 1 to 4 carbon atoms or di(C1 4)alkylamino; R9 is alkyl of 1 to 4 carbon atoms; phenyl optionally substituted with alkyl or halogen; or the group -NR10R11 , in which R10 and R11 are alkyl of 1 to 6 carbons or taken together with the nitrogen form a morpholino, piperidyl, or pyridyl ring. At least one of the substituents Rê or R7 must be other than phenyl (unsubstituted) or alkyl, and the substituent on the corresponding carbamate nitrogen (R3 or R6, respectively) must be alkyl of 1 to 4 carbon atoms Thus it is further provided: (1) when RÚ is OR4, SR5, or EMI3.1 R2is other than alkyl or phenyl and R3 is alkyl of 1 to 4 carbon atoms, and (2) when R1 is EMI3.2 (a) R2 is other than alkyl or phenyl and R3 is alkyl of 1 to 4 carbon atoms; or (b) R7 is other than alkyl or phenyl and R6 is alkyl of 1 to 4 carbon atoms. Accordingly, when R2 is other than alkyl or phenyl and R3 is alkyl of 1 to 4 carbon atoms the structure of R6 and R7 may vary widely within the definition given above. Similarly, where R7 is other than alkyl or phenyl and R6 is alkyl of 1 to 4 carbon atoms the structure of R2 and R3 may be varied in like fashion. It will thus be understood by those skilled in the art that the present invention embraces and is applicable to the N-sulfiny1 derivatives of virtually all known insecticidal carbamates, including, for example, those known by the common names carbofuran, carbaryl, aminocarb, bufencarb, butacarb, dioxacarb, ethiofencarb, methiocarb, isoprocarb, promecarb, propoxur, bendiocarb, aldicarb, methomyl, thiofanox, oxamyl, mexacarbate and others well known to those skilled in the art, including molecules containing any two such carbamates linked together by the sulfinyl group. The N-chlorosulfinylcarbamates (II) of the invention, compounds of formula I in which R1 is chloro, are prepared by reacting a carbamate starting material with thionyl chloride according to the general reaction scheme: EMI4.1 The reaction may be run without solvent with heating to form the corresponding N-chlorosulfinyl derivative and HCl. This reaction is generally carried out at a temperature ranging from about 60 to about 100 C. Excess thionyl chloride, is generally employed, and up to about a 508 molar excess is desirable. Hydrogen chloride is evolved during the reaction and excess thionyl chloride is removed. The reaction between the carbamate starting material and thionyl chloride may also be carried out in a solvent, suitably a polar non-hydroxylic or nonpolar organic solvent which will not react with thionyl chloride. Examples of suitable solvents are tetrahydrofuran, dichloromethane and hexane. An acid or hydrogen chloride acceptor is added to aid the reaction. A preferred acid acceptor is pyridine, but other tertiary organic amines can be employed as acid acceptors, including dimethyfaniline or diethylani line, as well as numerous other acid acceptors well known to those skilled in the art. The reaction employing an organic solvent and acid acceptor car, be carried out from room temperature up to an elevated temperature of about 60"C. When employing an organic solvent and acid acceptor, stoichiometric molar amounts of thionyl chloride and carbamate are employed. However, if desired a small molar excess of thionyl chloride, for example up to about 10% molar excess based on the carbamate, can be employed. Approximately equimolar amounts of acid acceptor and carbamate starting material generally are employed. However, a molar excess of acid acceptor, for example up to about at a 258 molar excess, may be employed if desired. Examples 1 and 2 illustrate preparation of Nchlorosulfinylcarbamate esters (II) according to the invention. EXAMPLE 1 Synthesis of 2,3-dihydro-2,2-dimethylbenzofurany 7 (chlorosulfinyl)(methyl)carbamate. Five and one-half grams of carbofuran (2,3-dihy- dro-2,2-dimethylbenzofuranyl-7 methylcarbamate) (0.025 mol) were dissolved in 25 ml dry tetrahydrofuran. To this solution was added 2.5 g pyridine (0.032 mol) followed by 3.5 g thionyl chloride (0.03 mol). The mixture was stirred at room temperature for 6 hours, then filtered under nitrogen to remove pyridine hydrochloride. The solvent was evaporated under vacuum, and the viscous solution was subjected to high vacuum (0.05 mm) for 1 hour. NMR of the residue in chloroform-d-TMS showed the following absorptions: 7.3-6.7 (m, 3H, aromatic protons), 63.25 (s, 3H, NCH3), 63.05 (s, 2H, benzylic CH2), g 1.45 (s, 6H, gem-diCH3). EXAMPLE 2 Synthesis of 3-isopropylphenyl (chlorosulfinyl) (methylfcaramate. , Four grams 3-isopropylphenyl methylcarbamate were mixed with excess thionyl chloride and heated up to 80"C until HCl evolution ceased. Excess thionyl chloride was removed by distillation and the residue was subjected to high vacuum (0.1 mm) for 1 hour. NMR of the residue in chloroform-d-TMS gave the following absorptions: 67.5-6.9 (m, 4H, aromatic protons), 63.25 (s, 3H, NCH3), 63.2-2.7 (m, 1H, CH), and 61.3-1.2 (d, 6H, C(CH3)2). The following compounds further illustrate the N-chlorosulfinylcarbamates of this invention: Example Compound 3 Isopropyl (chlorosulfinyl) (phenyl)carbamate 4 1-Naphthyl (chlorosulfinyl) (methyl)carbamate 5 2-Isopropoxyphenyl (chlorosulfinyl) (methyl)- carbamate 6 S-Methyl-N-fichlorosulfinylj(methyl)carbamoy- loxy] thioacetimidate 7 2-Methyl-2-(methylthio)propionaldehyde O- [(chlorosulfinyl) (methyl)carbamoyl]oxime These N-chlorosulfinylcarbamates are useful intermediates for preparing the pesticides of this invention. As shown in the preceding examples these compounds may be prepared and isolated, in which case they may then be reacted with nucleophilic reactants such as alcohols, phenols, thiols, amines, carbamates, amides, sulfonamides, ureas, and sulfonyl ureas, and the like, forming the pesticides of this invent ion. It is preferable, however, to form the sulfinylcarbamate in place by reaction of the carbamate and thionyl chloride, then to react it without isolation with the appropriate substrate. The resulting products are effective pesticides for agricultural crop and household pests having insecticidal, nematicidal, miticidal, larvicidal and acaricidal activity, depending upon the structure of the particular carbamate ester and the functional groups. The examples below illustrate conversion in place (wthout isolation) of the N-chlorosulfir!ylcarbamate (11) of the invention to carbamate compounds useful as pesticides in accordance with the following general reactions: EMI7.1 Without isolation, the N-chlorosulfinylcarbamate ester reacts in place with the reactants mentioned above in the presence of an equimolar amount or molar excess of an acid or hydrogen chloride acceptor, to form the pesticidal N-sulfinylcarbamate esters, III, IV, V, or VI. The temperature of the reaction medium varies according to the reactivity of the particular reactant, and reaction system employed, but in general, can be carried out at temperatures from about 0 C to 70 C, preferably 10 C to 60"C. Examples 8 and 9 illustrate preparation of N- (alkoxy- and aryloxy-)sulfinylcarbamates (III); that is, compounds of formula I in which R1 is -OR4, by in place reaction of the corresponding N-chlorosulfinylcarbamate (II) with an appropriate alcohol or phenol in accordance with general reaction scheme (A). EXAMPLE 8 Synthesis of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 (methyl)(hexoxysulfinyl)carbamate A mixture of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 methylcarbamate (5.5 g, 0.025 mol), pyridine (2.5 g, 0.032 mol), thionyl chloride (3.0 g, 0.025 mol), and 25 ml anhydrous tetrahydrofuran, was stirred at room temperature for 6 hours. Pyridine hydrochloride separated immediately after mixing, and stirring was continued to insure complete reaction. To this mixture was added 2 g pyridine (0.025 mol) followed by 3 g hexyl alcohol (0.029 mol) added dropwise. After stirring for an additional hour, ether (150 ml) was added to the reaction mixture. The mixture was washed with water three (30 ml each) times. The ether solution was dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. Unreacted carbamate (about 0.5 g) crystallized out and was filtered. The remaining liquid, 7.4 g, was almost free from unreacted carbamate as evident from the NMR spectrum of this crude product. A sample of this product was further purified by preparative thin layer chromatography using etherhexane (3:1) mixture as the developing solvent. Analysis calculated for C18H2705NS; Carbon, 58.51%. Hydrogen, 7.37%. Found: Carbon, 59.24%, Hydrogen, 8.08t. EXAMPLE 9 Synthesis of 3-isopropylphenyl (methyl) (n-butoxy- sulfinyl)carbamate To a solution of 3-isopropylphenyl methylcarbamate (3.5 g, 0.018 mol) in 20 ml anhydrous tetrahydrofuran was added 1.9 g pyridine (0.024 mol) and 2.5 g thionyl chloride (0.021 mol). The mixture was stirred for 12 hours at room temperature in order te insure complete conversion of the carbamate to the N-chiorosuir'inyi derivative Pyridine (2 g, 0.025 mol) was added, followed by 2 g n-butanol (0.027 mol), added dropwise. The mixture was stirred for an additional hour at room temperature and worked up similarly to example 8. h sample was purified by thin layer chromatography as previously described. Analysis calculated for C15H2304NS; Carbon, 57.48%, Hydrogen, 7.40%. Found: Carbon, 57.80t, Hydrogen, 7.21%. Examples 10 through 22, 61, and 62, set forth in Table I, further illustrate the N-(alkoxy- and aryloxy-) sulfinylcarbamates of this invention, having the substituent group -oR4. Examples 23 and 24 illustrate preparation of N (alkylthio- and arylthio-)sulfinylcarbamates (IV) of this invention; that is, compounds of formula I in which RÚ is -SR5, by reacting in place the corresponding N-chlorosulfinylcarbamate (II) and an appropriate thiol, in accordance with general reactic scheme (B). EXAMPLE 23 Synthesis of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 (methyl)(n-butylthiosulfinyl)carbamate. To a solution of 4.4 g (0.02 mol) 2,3-dihydro-2, 2-dimethylbenzofuranyl-7 methylcarbamate in 20 ml dry tetrahydrofuran was added 1.9 g (0.024 mol) pyridine followed by 2.5 g (0.021 mol) thionyl chloride. The mixture was stirred at room temperature for 4 hours. Pyridine (1.9 g, 0.024 mol) was added, and the mixture was cooled in an ice-water bath. To this stirring solution was added, dropwise, 1-butanethiol (1.8 g, 0.02 mol) in 2 ml tetrahydrofuran. After the complete addition of the thiol, the mixture was allowed to warm up to room temperature, and was kept at this temperature for 1/2 hour. Ether, 150 ml, was added, and the mixture was washed four times (25 ml each) with water. The ether solution was dried over anhydrous sodium sulfate and the solvent was evaporated under vacuum. The residue was subjected to high vacuum f Oe 1 mm) for several hours. NMR spectrum of this crude product showed a complete conversion of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 methylcarbamate to its butylthiosulfinyl derivative. An analytical sample was obtained by preparative thin-layer chromatography. Analysis calculated for C16H23NO4S2; Carbon, 53.75%; Hydrogen, 6.488. Found: Carbon, 53.97%; Hydrogen, 6.48%. EXAMPLE 24 Synthesis of 3-isopropylphenyl (methyl) (2-methyl 4-t-butylphenylthiosulfinyl)carbamate, To -a solution of 4.0 g 3-isopropylphenyl methylcarbamate in 20 ml dry tetrahydrofuran was added 1.9 g pyridine (0.024 mol) and 2.5 g thionyl chloride (0.021 mol). The mixture was stirred at room temperature for 6 hours. Pyridine (1.9 g, 0.024 mol) was added and followed by 3.6 g of 2-methyl-4-t-buty1benzenethiol (0.02 mol) added dropwise at room temperature The mixture was stirred for an additional hour and 150 ml ether was added. The mixture was worked up similar to example 22 and a sample of the oily product was purified by thin-layer chromatography. Analysis calculated for C 22H29NO3S2; Carbon, 62.97%; Hydrogen, 6.97%. Found: Carbon, 63.408; Hydrogen, 6.89%. Examples 25 through 36, set forth in Table I, further illustrate the N-(alkylthio- and arylthio-)sulfinylcarbamates of this invention. Examples 37 and 38 illustrate preparation of N,N'- sulfinyldicarbamates (V) of the invention; that isr compounds of formula I wherein R3 is EMI10.1 This group of compounds can be either symmetrical or asymmetrical about the sulfinyl sulfur. In the asymmetrical compounds R7 above is the same as R2 and R6 is the same as R30 These symmetrical compounds can be readily prepared in a one step process according to the following general reaction scheme EMI11.1 The above reaction of the carbamate ester starting material and thionyl chloride is carried out using an acid acceptor such as triethylamine in an inactive polar solvent such as tetrahydrofuran. The carbamate ester product can be formed in high yield employing two moles of the carbamate ester starting material per mole of thionyl chloride, at from 0 C to 50 C, suitably at room temperature (20"C), using about two moles or a slightly greater proportioh of acid acceptor, such as triethylamine, per mole of the carbamate starting mae- rial. Example 37 illustrates this method of preparation. Symmetrical N,N'-sulfinyldicarbamates can also be prepared by the following reaction scheme EMI11.2 This procedure is less convenient as compared to the direct reaction of thionyl chloride with the carbamate However, it can be useful if R2 is substituted by functional groups that are susceptible to thionyl chloride such as unsubstituted or monoalkyl substituted amides or aromatic and aliphatic amines. Asymmetrical N,N'-sulfinyldicarbamates can be prepared by reacting N-chlorosulfinylcarbamates (II) with an alkyl, aryl, or oxime carbamate starting material in accordance with reaction scheme (C) above. Example 38 illustrates this method of preparation. EXAMPLE 37 Synthesis of N,N'-sulfinyldi-(2,3-dimethyl-2,- 3-dihydrobenzofuranyl-7 methylcarbamate). To a solution of 2,2-dimethyl-2,3-dihydrobenzofuranyl-7 methylcarbamate (4.4 g, 0.02 mol) in 20 ml dry tetrahydrofuran was added 1.2 g thionyl chloride (0.01 mol). The mixture was stirred and cooled in an ice-water bath (temperature < 10oC). Triethylamine (2.0 g, 0.02 mol) was added dropwise to the mixture The temperature was allowed to rise up to room temperature after the complete addition of the amino Stirring was continued for an additional one hour at room temperature, and 150 ml ether was added The mixture was washed with water four times (25 ml each) and dried over anhydrous sodium sulfate. Evaporation of the solvent resulted in a solid material which was crystallized from benzene-hexane to give 3.5 g (yield 71.7%) of product, mp 139-142"C. Analysis calculated for C24H2BN207S; Carbon, 59.00%; Hydrogen, 5.78%. Found: Carbon, 59.60%, Hydrogen, 5.548. EXAMPLE 38 Synthesis of S-methyl N-[N-(N"-ethyl-N"-(n-pro- poxycarbonylaminosulfinyl)-N'-methylcarbamoyloxy] thioacetimidate. To a solution of S-methyl N-(N'-methylcarbamoyloxy) thioacetimidate (3.3 g, 0.02 mol) in 2Q ml anhydrous dichloromethane, was added 4.3 g of propyl (ethyl) (chlorosulfinyl)carbamate (prepared from propyl ethylcarbamate and thionyl chloride, b.p. 65-69"C at 0.5 mm) and 1.6 g (0.02 mol) anhydrous pyridine. The mixture was stirred for twelve hours at room temperature. Ether (100 ml) was added and the mixture was washed with water three (30 ml each) times. The ether solution was dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. A sample of the oily residue was purified by preparative thin-layer chromatography using ether-hexane (3:1) mixture as the developing solvent. Analysis calculated for C11H21N305S2; Carbon, 38.92%; Hydrogen, 6.23%. Found: Carbon, 38.38%; Hydrogen, 5.78%. Examples 39 through 48, shown in Table I, further illustrate the N,N1-sulfinyldicarbamates of this invention. Examples 49 through 51 illustrate preparation of sulfonylaminosulfinylcarbamates (VI); that is, compounds of formula I in which R1 is EMI13.1 in accordance with reaction scheme (D) above. EXAMPLE 49 Synthesis of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 N-(N'-benzenesulfonyl-N'-methylaminosulfinyl)-N methylcarbamate. To a solution of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 methylcarbamate (4.4 g, 0.02 mol) in 15 ml tetrahydrofuran, was added pyridine (2.0 g, 0.025 mol) and thionyl chloride (2.5 g, 0.021 mol). The mixture was stirred for 4 hours at room temperature. The reaction mixture was filtered rapidly from pyridine hydrochloride. N-Methylbenzenesulfonamide (3.5 g, 0.02 mol) was added and the mixture was cooled in an ice water bath. Triethylamine (2.2 g, 0.022 mol) was added dropwise while stirring. The mixture was stirred at room temperature for an additional half hour and diluted with 100 ml ether. The ether solution was washed with water three times (30 ml each) and then dried over anhydrous sodium sulfate. Ether was evaporated under vacuum and the residue was subjected to high vacuum for 2 hours. A sample of the product was purified by thin layer chromatography using ethyl acetate-hexane mixture (1:3) as the developing solvent. NMR of the purified product in chloroform-d-TMS showed the following absorptions: 68.0-6.6 (m, 8H, aryl protons), 63.0 (s, 2H, benzylic CE2), 62.9 and 62.85 (two singlets, 3H each, CONCH3 and SO2NCH3), 61.5 (s, 6H, gem-di CE3). EXAMPLE 50 Synthesis of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 N-(N'-methanesulfonyl-N'-ethylaminosulfinyl)-N methylcarbamate. To a solution of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 methylcarbamate (4.4 g, 0.02 mol) in 15 ml tetrahydrofuran was added pyridine (2.0 g, 0.025 mol) and thionyl chloride (2.5 g, 0.021 mol). The mixture was stirred at room temperature for 4 hours. Pyridine (2.0 g, 0.025 mol) was added and followed by N-ethyl methanesulfonamide (2.7 g, 0.022 mol) and stirring was continued overnight. Workup and purification of the final product were carried out similarly to Example 49. NMR of the purified product in chloroform-d-TMS showed the following absorptions: 67.1-6.7 (m, 3H aromatic protons), 63.75- 3.55 (g, 2H, NCH2), 63.15 (s, 6H, CONCH3 and SO2CH3), 63.05 (s, 2H, benzylic CH2), 61.5 (s, 6H, gem-di CH3), 61.45-1.2 (t, 3H, CH3). EXAMPLE 51 Synthesis of 2,3-dihydro-2,2-dimethylbenzofuranyl-7 N-(N'-dibutylaminosulfonyl-N'-methylaminosulfinyl)- N-methylcarbamate. Methylisocyanate (24.0 g, 0.42 mol) was added dropwise to a cooled mixture of 40 gm 20% fuming sulfuric acid in 100 ml nitromethane. After the complete addition of the isocyanate, the resulting suspension was refluxed for 10 minutes. The mixture was filtered and the collected crystalline methylsulfamic acid was washed with ether and air dried to give 34.5 g of the dry acid (74% yield). Methylsulfamic acid (33 g, 0.3 mol) was mixed with 62.5 g PCl5 in 100 ml benzene. The mixture was heated gently until gas evolution occurred. The heat source was removed and the reaction continued spontaneously at room temperature. After most of the solids were dissolved the mixture was refluxed with stirring for a half hour. Evaporation of the solvent and distillation of the residue under vacuum gave 32 g of methylsulfamyl chloride b.p. 90-92"C./6.5 mm (82% yield). Methylsulfamyl chloride (7.2 g, 0.056 mol) wa dissolved in 75 ml dry benzene. Dibutylamine (15 gt 0.116 mol) was added dropwise at 10 C to the solution and the mixture was stirred at room temperature for 2 hours. The mixture was washed with water twice and dried over anhydrous calcium chloride. The solvent was evaporated and the residue was distilled under vacuum, to give 7.0 g of product b.p. 145-1460C/0.1 mm, which was identified as N-methyl-N',N'-dibutylsulfon- diamide by NMR spectroscopy. 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 methylcarbamate (4.4 g, 0.02 mol) was dissolved in 20 ml dry tetrahydrofuran. To this solution was added pyridine (2.0 g, 0.025 mol) followed by thionyl chloride (2.5 g, 0.021 mol). The mixture was stirred at room temperature for 6 hours. Then pyridine (2.0 g, 0.025 mol) was added and followed by N-methyl-N',N'-dibutylsulfondi amide (5.0 g, 0.023 mol). The mixture was stirred at room temperature overnight and ether (150 ml) was added. The mixture was washed with water three times (50 ml each) and the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under vacuum and the residue was crystallized from hexane, m.p. 75-76eC. NMR of the product in chloroform-d-TMS showed the following absorptions: 67.15-6.7 (m, 3H, aromatic pro tons),63.35-3.1 (t, 4H, 2NCH2), 63.1 (s, 3H, CONCH3), 63.05 (s, 2H, benzylic CH2),62.9 (s, 3H, SO2NCH3), 61.8-1.1 (m, 8H, alkyl 4CH2),61.5 (s, 6H, gem-diCH3), 61.1-0.85 (t, 6H, alkyl 2CH3). Examples 52 through 60, set forth in Table I, further illustrate the sulfonylaminosulfinyl carbamates of this invention. The insecticidal compounds of the invention may be formulated with the usual carriers, including additives and extenders used in the preparation of the insecticidal compositions. Thus, the toxicants of this invention, like most insecticidal agents, are generally not applied full strength, but are incorporated with the adjuvants and carriers normally employed for facilitating the dispersion of active ingredients, recognizing the accepted fact that the formulation and mode of application of a toxicant may affect the activity of the material. The present compounds may be made into liquid concentrates by solution or emulsification in suitable liquids such as organic solvents, and into solid concentrates by admixing with talc, clays and other known solid carriers used in the insecticide art. These concentrates are compositions containing about 5 to about 95% toxicant and the rest inert material which includes dispersing agents, emulsifying agents, and wetting agents. The concentrates are diluted for practical application, with water or other liquid for liquid sprays or with additional solid carrier for application as a dust or granular formulation. The concentration of the toxicant jn the dilution generally used for application is normally in the range of about 10% down to about 0.001% depending on the means available for application. Many variations of spraying and dusting compositions in the art may be used, by substituting a compound of this invention into the compositions known or apparent to the art. The present compounds may also be made into compositions which may be applied without further dilution, for example dusts, powders and granules. These ready to use formulations generally contain from about 0.1% to 50% of the toxicant, preferably about 1.0 to about 458. The insecticidal compositions may be formulated and applied with other active ingredients, including other insecticides, nematicides, acaricides, fungicides, plant regulators, fertilizers, etc. In applying the chemicals, it is obvious that an effective amount and concentration of the carbamate ester compounds of the invention should be employed. Representative compounds of the invention were tested for insecticidal activity against two insect species, house flies, Musca domestica, and mosquito larvae, Culex pipiens. Stock 1% concentrated solutions of each of the test compounds were made in acetone, and such solutions diluted with acetone to a concentration of 0.001-0.1%. House flies were treated topically on the notum by 1 pQ of each of the diluted acetone solutions. Following application, the insects were held at a constant temperature of 60 F. Percent mortality was counted 24 hours after application. Larvicidal activity was determined by applying 1 ml of the acetone solutions in 100 ml of water containing 20 3rd instar mosquito larvae. Results are presented as LD50 in pg/g for house flies and LC50 in ppm for mosquito larvae. Mammalian toxicity was determined against Swiss white mice. The test compound was administered orally using corn oil as the carrier. Results are given as LD50 in mg of compound per kg body weight. The test data for N-sulfinylcarbamates of the invention are summarized in Table II. In that table the term "LD501, represents the dose needed to kill 508 of the test animals, and the term 'µLC50" is the concentration needed to kill 50% of the mosquito larvae. In interpreting the values in the table, the lower the value for LD50 for house flies and for LC50 for mosquito larvae, the greater is the insecticidal potency or toxicity of that particular compound. On the other hand, the higher the value of LD50 for mice, the lower the mammalian toxicity or the greater is the mammalian safety of such compound. Referring now to Table II, the parent carbamate ester material of the compounds of Examples 8, 10-13, 23, 25-28, 37, 43-46, 49-51, 58 and 59, carbofuran, (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate) has an LD50 for house flies of about 6.5 and an LD5Q for mice in the range of about 2 to about 8 mg/kg. In Table II it is shown that while the corresponding compounds of this invention have a relatively comparable LD50 for house flies (insecticidal activity), ranging from 2.2 to 20 ijg/g, all have much higher LD50 values for mice, ranging from 40 to 280, evidencing substantially lower mammalian toxicity and thus a higher margin of safety. Similarly the other compounds of this invention retain insecticidal activity relatively comparable to that of the carbamate ester on which they are based but have substantially reduced mammalian toxicity and thus substantially greater mammalian safety. TABLE I Example Number Compound Name 10 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl)(t-butoxysulfinyl)carbamate 11 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl)(n-butoxysulfinyl)carbamate 12 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl)(phenoxysulfinyl)carbamate 13 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl)(2,6-dimethylphenoxysulfinyl) carbamate 14 3-Isopropylphenyl (methyl) (n-hexoxysulfinyl)- carbamate 15 2-Isopropoxyphenyl (methyl) (n-hexoxysul finyl ) carbamate 16 2-Isopropoxyphenyl (methyl)(t-butoxysul finyl ) carbamate 17 S-Methyl N-[N'-methyl-N'-hexoxysulfinylcar bamoyloxythioacetimidate 18 S-Methyl N-[N'-methyl-N'-butoxysulfinylcar bamoyloxy]thioacetate 19 2-Methyl-2-(methylthio)propionaldehyde O [(methyl)(decoxysulfinyl)carbamoyl]oxime 20 1-Naphthyl <RTI ID=19.4> (methyl) (hexoxysulfinyl)carbamate 21 2,2-dimethyl-1,3-benzodioxolyl-4 (methyl) (n-butoxysulfinyl ) carbamate 22 S-methyl N',N'-dimethyl-N-(n-butoxysulfinyl) (methyl)carbamoyloxy-1-thio-oximidate 25 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl) (t-butylthiosulfinyl)carbamate 26 2, 3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl) - (phenylthiosulfinyl)carbamate 27 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl)- (4-t-butylphenylthiosulfinyl)carbamate 28 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 (methyl) (2-methyl-4-t-butylphenylthiosulfinyl)carbamate TABLE ,- (Cont'd) Example Number Compound Name 29 2-Isopropoxyphenyl (methyl) (n-butylthiosul- finyl)carbamate 30 2-Isopropoxyphenyl (methyl)(2-methyl-4-t-butyl- phenylthiosulfinyl)carbamate 31 S-Methyl N-[N'-methyl-N'-t-butylthiosulfinyl carbamoyloxy]thioacetimidate 32 S-Methyl N-[N'-methyl-N'-phenylthiosulfinyl carbamoyloxy]thioacetimidate 33 3-Isopropylphenyl (methyl)(t-butylthiosulfinyl) 34 2-Methyl-2-(methylthio)propionaldehyde O- [(methyl) (dodecylthiosulfinyl)carbamoyl]oxime 35 1-Naphthyl (methyl)(t-butylthiosulfinyl)car bamate 36 1-Naphthyl (methyl)(phenylthiosulfinyl)carbam ate 39 N,N-Sulfinyldi-(2-isopropoxyphenyl methyl carbamate) 40 N,N'-Sulfinyldi-[S-methyl N11-(methylcarbamoy- loxy)thioacetimidate 41 N,N'-Sulfinyldi-[2-methyl-2-(methylthio)pro- pionaldehyde O-(methylcarbamoyl)oxime] 42 S-Methyl N-[N'-(N"-methyl-N"-(n-propoxycar bonylaminosulfinyl)-N'-methylcarbamoyloxy) thioacet imidate 43 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 N-[N'- (methoxycarbonyl)-N'-(methylaminosulfinyl)] N-methylcarbamate 44 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 N-[N'- (ethoxycarbonyl)-N'-(methylaminosulfinyl)] N-methylcarbamate 45 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 N-[N'- (n-propoxycarbonyl)-N'-(methylaminosulfinyl)] N-methylcarbamate TABLE I (Cont'd) Example Number Compound Nae 46 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 N-[Ntr (heptoxycarbonyl)-N'-(methylaminosulfinyl)) N-methylcarbamate 47 2-Isopropoxyphenyl N-[N'-(n-propoxycarbonyl) N'-(methylaminosulfin)-N-methylcarbamate 48 3-Isopropylphenyl N-[N'-(methoxycarbonyl)-N' (methylaminosulfinyl)]-N-methylcarbamate 52 2-Isopropoxyphenyl N-(N'-benzenesulfonyl-N' methylaminosulfinyl)-N-methylcarbamate 53 3-Isopropylphenyl N-(N'-benzenesulfonyl-N' methylaminosulfinyl)-N-methylcarbamate 54 1-Naphthyl N-(N'-benzenesulfonyl-N!-m2thyl- aminosufinyl)-N-methylcarbamate 55 S-Methyl N-[N'-(N"-benzenesulfonyl-N"-methyl aminosulfinyl)-N'-methylcarbamoyloxy]thio acetimidate 56 3-Isopropylphenyl N-(N'-methanesulfonyl-N' ethylaminosulfinyl )-N-methylcarbamate 57 S-Methyl N-[N'-(N"-methanesulfonyl-N'-ethyi aminosulfinyl)-N'-methylcarbamoyl]thioace timidate 58 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 N-[N'- (N"-morpholinosulfonyl)-N'-methylaminosulfinyl) N-methylcarbamate 59 2,3-Dihydro-2,2-dimethylbenzofuranyl-7 N morpholinosulfonyl-N'-ethylaminosulfinyl)-N methylcarbamate 60 S-Methyl N-[N'-(N"-dibutylaminosulfonyl-N" methylaminosulfinyl)-N'-methylcarbamoyloxy) thioacetimidate 61 2,3-dihydro-2,2-dimethylbenzofuranyl-7 (methyl) (ethynylmethoxysulfinyl ) carbamate 62 3-i-propylphenyl (methyl) (ethynylmethoxy:u finyi)carbamate Physical data of Compounds in TABLE I Physical Properties Ex. Elemental Analysis Melting Pt. ( C) or NMR Spectrum* No. Calcd (%) Found% Boiling Pt. (4 ymm Hg) ppm 10 C 56.28 C 56.74 purified by TLC 7.0-6.8 (m,3H) H 6.79 H 6.32 1.48 (s,6H) 3.0 (2s,5H) 1.50 (s, 9H) 11 C 56.28 C 56.21 purified by TLC 7.0-6.8 (m,3H) H 6.79 H 6.94 3.05 (2s,5H) 4.1-3.9 (m,2H) 1.6-1.0 (m,3H) 12 C 59.82 C 61.19 purified by TLC 7.1-6.8 (m,8H) H 5.3 H 5.38 2.92 (s,3H) 3.02 (s,2H) 1.5 (s,6H) 13 C 61.68 C 62.02 purified by TLC 7.1-6.8 (m,6H) H 5.95 H 6.29 2.37 (s,2H) 3.24 (s,3H) 1.45 (s,6H) 3.05 (s,2H) 14 C 59.8 C 60.43 purified by TLC 7.2-6.8 (m,4H) H 7.97 H 8.52 3.1 (2s,4H) 4.1-3.9 (m,2H) 1.4-0.8 (m,17H) 15 C 57.13 C 57.43 purified by TLC 7.2-6.9 (m,4H) H 7.62 H 7.99 4.2-3.9 (m,2H) 4.7-4.4 (g, 1H) 3.0 (s,3H) 1.5-0.9 (m,17H) 16 C 54.69 C 55.16 purified by TLC 7.2-6.8 (m,4H) H 7.04 H 7.00 2.5-2.2 (m,15H) 4.7-4.4 (q,lH) 3.0 (s,3H) 17 C 42.58 C 43.62 purified by TLC 4.0-3.8 (m,2H) H 7.15 H 7.67 2.3 (s,3H) 3.0 (s,3H) 1.5-0.9 (m,llH) 2.40 (s,3H) TABLE (Cont 'd Physical Properties Ex. Elemental Analysis Melting Pt. ( C) or NMR Spectrum* No. Calcd. (%) Found % Boiling Pt. ( C/mm Hg) (ppm CDCl3) 18 C 38.28 C 38.71 mp 52-54 C 4.2-3.9 (m, 2H) H 6.42 H 6.57 2.4 (s,3H) 3.0 (s,3H) 2.3 (s,3H) 1.7-0.9 (m, 7H) 19 C 51.74 C 51.99 purified by TLC 7.5 (s,lH) H 8.69 H 8.55 2.0 (s,3H) 4.0-3.8 (m,2H) 1.5-0.9 (m, 25H) 2.95 (s,3H) 20 C 61.87 C 61.94 purified by TLC 8.0-7.3 (m,7H) H 6.63 H 6.65 3.15 (s,3H) 4.15-3.9 (m, 2H) 1.9-0.8 (m, 11H) 21 purified by TLC 6.8-6.5 (m,3H) 3.0 (s,3N) 4.1-3.85 (m ,2H) 1.7-0.8 (m, 13H) 22 purified by TLC 4.1-3.7 (m, 2H) 2.33 (s, 3H) 3.1 -2.9 (m, 9H) 1.7-0.8 (m, 7H) 25 C 53.75 C 54.12 purified by TLC 7.15-6.8 (m,3H) H 6.48 H 6.51 1.6 (s,9H) 3.25 (s,3H) 1.45 (s,6H) 3.05 (s, 2H) 26 C 57.27 C 57.70 purified by TLC 7.7-6.7 (m,8H) H 5.07 H 4.76 1.4 (s, 5H) 3.2 (s, 3H) 3.0 (s, 2H) TABLE (Cont'd) Physical Properties EX. Elemental Analysis Melting Pt. ( C) or NMR spectrum* No. Called (%) Found% Boiling Pt. ( C/mm Hg) (ppm CDCl3) 27 C 60.94 C 61.31 purified by TLC 7.1-6.8 (m, 3H) H 6.28 H 6.08 1.6 (s,9H) 3.27 (s,3H) 1.46 (s,6H) 3.02 (s,2H) 28 C 61.72 C 61.97 purified by TLC 7.8-6.8 (m,7H) H 6.53 H 6.74 1.5 (s,6H) 3.2 (s,3H) 1.32 (s,9H) 3.08 (s,2H) 29 C 52.14 C 52.80 purified by TLC not taken H 6.71 H 6.79 30 C 60.66 C 61.15 purified by TLC not taken H 6.71 H 6.71 31 C 36.22 C 36.80 mp 51-53 C not taken H 6.08 H 6.29 32 7.8-7.25 (m,5H) 3.25 (s,3H) 2.4 (s, 3H) 2.25 (s, 3H) 33 C 54.68 C 54.55 purified by TLC not taken H 7.04 H 6.83 34 C 52.01 C 52.59 purified by TLC not taken H 8.73 H 9.01 35 C 56.95 C 57.51 purified by TLC not taken H 5.68 H 6.82 36 8. 1-6.9 (m, 12H) 3.2 (s,3H) 39 C 56.88 C 57.31 7.4-6.8 (m,8H) H 6.08 H 6.00 mp 71-74 C 1.3-1.2 (d,12H) 4.8-4.3 (m,2H) 3.1 (s,6H) 40 C 32.45 C 32.86 3.0 (s,6H) H 4.90 H 5.02 mp 142-143 C 2.23 (s,6H) 2.35 (s,6H) TABLE (Cont'd) Physical Properties Ex. Elemental Analysis Melting Pt. ( C) or NMR Spectrum* No. Calcd (8) Found% Boiling Pt. ( C/mm Hg) ( 41 C 39.42 C 39.84 mp 61-63 C 7.65 (s, 2H) H 6.14 H 5.96 1.5 (s, 12H) 3.0 (s,6H) 2.0 (s,6H) 42 C 36.91 C 37.65 purified by column 4.34-4.1 (t, 2H) H 5.89 H 6.47 chranatography 3.35 (s,3H) 3.0-2.95 (2s, 6H) 1.9-1.6 (m, 2H) 3.47 (s,3H) 1.16-0.85 (t, 2H) 43 C 50.55 C 51.16 purified by TLC 7.1-6.7 (m,3H) H 5.66 H 5.84 1.23 (s,6H) 3.56 (s, 3H) 2.9-2.7 (m, 6H) 44 C 51.88 C 52.33 not taken H 5.98 H 6.98 45 C 53.10 C 53.15 not taken H 6.29 H 6.29 46 C 57.25 C 57.56 not taken H 7.32 H 7.32 47 C 51.55 C 51.11 not taken H 6.44 H 6.98 48 C 51.20 C 52.06 not taken H 6.14 H 6.14 52 8.1-6.8 (m, 9H) 4.7-4.35 (m,1H) 3, 2.85 (2s, 3H ea.) 1.35-1.25 (d,6H) 53 8.1-6.9 (m, 9H) 3, 2.9 (2s, 3H, ea.) 3.2-2.7 (m, 1H) 1.3-1.2 (d, 6H) 54 8.2-7.3 (m, 12H) 3.1, 2.9 (2s, 3H ea.) TABLE (Cont'd) Physical Properties EX. Elemental Analysis Melting Pt. ( C) or NMR Spectrum No. Calcd (%) Found % Boiling Pt. ( C/mm Hg) (ppm CDCl3) 55 np 79-82iC 8.2-7.5 (m,5H) 2.95, 2.9 (2s,3H ea.) 2.45 (s,3H) 2.3 (s,3H) 56 7.4-6.9 (m,4H) 3.7-3.45 (q,2H) 3.1 (s,6H) 3.2-2.7 (m, 1H) 1.5-1.1 (m,9H) 57 mp 125-127 C 3.7-3.45 (q, 2H) 3.2 (s,3H) 3.05 (s,3H) 2.45 (s,3H) 2.3 (s,3H) 1.4-1.2 (t, 3H) 58 7.2-6.7 (m, 3H) 3.9-3.7 (m, 4H) 3.6-3.0 (m,4H) 3.1 (s,3H) 3.05 (s,2H) 3.0 (s,3H) 1.45 (s,6H) 59 7.2-6.7 (m,3H) 3.9-3.6 (m,4H) 3.6-3.0 (m,6H) 3.1 (s,3H) 3.0 (s,2H) 1.5 (s,6H) 1.5-1.3 (m,3H) 60 up 61-63 C 3-35-3.15 (t,4H) 3.0 (s,3H) 2.9 (s,3H) 2.4 (s,3H) 2.3 (s,3H) TABLE (Cont'd) Physical Properties EX. Elemental Analysis Melting Pt. ( C) or NMR Spectrum No. Calcd (%) Found % Boiling Pt. ( C/mm Hg) (ppm CDCl3) 1.8-1.1 (m, 8H) 1.05-0.75 (t, 6H) 61 6.-6.5 (m,3H) 2.85 (s, 2H) 4.5 (m, 2H) 1.33 (s,6E) 2.9 (s, 3E) 62 7.4-6.8 (m, 4H) 3.95-3.7 (m, 1H) 4.66-4.5 (m, 2H) 2.55-2.45 (m, 1H) 3.1 (s,3H) 1.3-1.2 (d, 6H) =singlet d = doublet t = triplet m = multiplet q = quartet TABLE II Compound House Flies Culex Mice of Example LD50 ( g/g) LC50 (ppm) LD50 (mg/kg) 8 13 0.0025 280 9 50 -- - 10 2.2 0.0058 40 11 16 -- 160 12 6.4 0.0055 42 13 13.5 -- 100 14 80 -- > 1000 15 42 0.01 > 1000 16 65 -- 400 17 6.5 -- 260 18 5.5 -- - 19 11.5 0.006 60 20 360 -- > 1000 23 16.5 -- 45 24 62.5 -- 450 25 9 0.01 70 26 7 0.05 32 27 11.8 -- 92 28 8.8 -- 70 29 31 -- 1050 30 27 -- > 1000 31 5.5 -- 135 32 6.5 -- 150 33 75 -- 250 34 12 -- - 35 235 -- > 1000 36 350 -- > 1000 37 20 -- 165 38 7.0 -- 115 39 85 -- 940 40 40 -- 210 41 6.5 -- 1.8 42 6.6 -- 160 TABLE II (Cont'd) Compound House Flies Culex Mice of Example LD50 ( g/g) LC50 (ppm) LD50(mg/kg) 43 9.0 -- 62 44 13.0 0.04 56 45 9.0 -- 100 46 13.5 0.015 150 47 20 0.18 500-1000 48 80 -- 70 49 9.5 35 50 12.5 -- 75 51 12 -- 25 52 55 -- 250 53 95 -- 150 54 450 -- > 500 55 17.5 -- 86 56 90 -- 200 57 25 -- 250 58 13 -- - 59 10 -- - 60 9 -- 100

Claims: CLAIMS: 1. A compound of the formula EMI30.1 characterized in that R1 is a halogen atom selected from bromine, chlorine and fluorine; -oR4,-SR5, EMI30.2 R2 and R7, the same or different, are alkyl of 1 to 8 carbon atoms; naphthyl; phenyl; an aryl group of the formula EMI30.3 or EMI30.4 wherein Ra is alkyl, alkoxy, alkylthio, alkylthio alkyl or 2-dioxolanyl, Rb is hydrogen, alkyl, alkoxy, alkoxyalkyl, formyl(alkyl)amino, or halogen, Rc is hydrogen, alkyl, alkoxy, alkylthio or dialkylamino, Rd is hydrogen or alkyl, and each alkyl of Ra, Rb, Rc or Rd group contains 1 to 6 carbon atoms; a heterocyclic group of the formula EMI30.5 in which R and Rf are hydrogen or alkyl of e 1 to 4 carbon atoms, A and B are each oxygen, or one of A and B is methylene and the other is oxygen or sulfur, attached at the 4 or 7 posi tion; or an imino group of the formula FgRhC=N- wherein Rg is hydrogen or alkyl of 1 to 4 carbon atoms and Rh is alkylthio, alkylthioalkyl or dialkyl aminocarbonyl in which the alkyl groups, the same or different, have 1 to 4 carbon atoms; R3, R6 and R8, the same or different, are alkyl of 1 to 4 carbon atoms or phenyl optionally substituted with alkyl of 1 to 4 carbon atoms or halogen; R4 and R5 are alkyl of 1 to 12 carbon atoms; an unsat urated aliphatic hydrocarbon of 2 to 4 carbon atoms, or phenyl optionally substituted with alkyl of 1 to 6 carbon atoms, alkylthio of 1 to 4 iS 4 carbons or di(C1-4)alkylamino; B" is alkyl of 1 to 4 carbon atoms; phenyl optionally substituted with alkyl or halogen; or the group 11 in which R10 and R11 @@ R F in @@@ R and R are alkyl of I to 6 carbons or taken together with the nitrogen form a morpholino, piperidyl, or pyridyl ring; with the provisos: (1) when R1 is -OR4, -SR5, or EMI31.1 , Rê is other than alkyl or phenyl and R is alkyl of to 4 carbon atoms; and (2) when RÚ is EMI31.2 (a) R2 is other than alkyl or phenyl and R3 is alkyl of 1-4 carbon atoms; or (b) R7 is other than alkyl or phenyl and R6 is alkyl of 1 to 4 carbon atoms. 2 The compound of claim 1 characterized in that R1 is -OR4. 3. The compound of claim 1 characterized in that RÚ is -SR5 4. The compound of claim 1 characterized in that R1 is EMI32.1 5. The compound of claim 4 characterized in that R7 is the same as R2 and R6 is the same as R3. 6. The compound of claim 4 characterized in that R7 and R2 are different. 7. The compound of claim 1 characterized in that RÚ is EMI32.2 8. The compound of claim 1 characterized in that at least one of R2 and R7 is a heterocyclic group of the formula EMI32.3 in which Re and Rf are- hydrogen or alkyl of 1 to 4 carbon atoms, A and B are oxygen or one of A and B is methylene and the other is oxygen or sulfur. 9. The compound of claim 8 characterized in that at least one of Rê and R7 is a 2,3-dihydro-2,2-dimethyl7-benzofuranyl group and at least one R3 and R6 is methyl. 10. The compound of claim 1 characterized in that at least one of Rê and R7 is naphthyl or a substituted aryl group of the formula EMI32.4 or EMI32.5 11. The compound of claim 1 characterized in that at least one of R2 and R7 is an imino group of the formula RgRhC=N¯. 12. The compound of claim 1 characterizea in tnat is chloro. 13. An insecticidal composition characterized ifl containing an insecticidally effective amount of the compound of claims 1,2,3,4,5,6,7,8,9,10, or 11, in admixture with an agriculturally acceptable adjuvant or carrier. 14. A method for control of insects in an agricultural crop characterized in applying to the crop or to the soil in which the crop is planted or is to be planted an insecticidally effective amount of the compound of claims 1,2,3,4,5,6,7,8,9,10, or 11. 15. A process for preparing the compound of claim 12 characterized in reacting a carbamate of the formula EMI33.1 with an equimolar amount or molar excess cf thionyl chloride 6. The process of claim 15 characterized in that said reaction is conducted without solvent with hexing. 17. The process of claim 15 characterized in that said reaction is conducted in the presence of a polar non-hydroxylic or non-polar organic solvent and an acid acceptor. 18. A process for preparing the compound of claims 2,3,4,6,7,8,9,10, or 11 characterized in reacting the compound of claim 13 with a compound of the formula R4OH, R5SH, EMI33.2 or EMI33.3 19. The process of claim 18 characterized in that the reaction is conducted in the presence of a non hydroxylic polar solvent or of a non-polar organit solvent in the presence of an acceptor. 20. The process of claim 19 characterized in that the compound of claim 12 is formed in place and reacted, without isolation, with a compound of the formula R40H, RSSH, EMI34.1 or EMI34.2 21. A process for preparing a compound of claim 5 characterized in reacting of a carbamate of the formula EMI34.3 with thionyl chloride in the presence of an acid acceptor and an inactive polar solvent, about 2 mols of said carbamate being employed per mol of thionyl chloride.

Inventors: FAHMY, MOHAMED ABDEL HAMID, FUKUTO, TETSUO ROY
Applicants: THE REGENTS OF THE  UNIVERSITY OF CALIFORNIA
Application year: 1980
Main classification: C07C145
IPC codes: C07D307, C07D317, A01N47