PHARMACEUTICAL PREPARATION

Abstract: A topical composition for rendering the skin aseptic, consisting of a combined form of iodine and an agent for promoting the absorption and dispersal of the composition in the epidermis.

Description: 7tvLό Iment on arvzzeAnΛ μh-Z-Am___cjeΛitAX.al μAe.μaAatlon6 ■{Lax. toμlcal aμμλlcatlon to the. JiLl -in aideA. to Λ.endeA the.4hL ΛuAf ce. aύe.μtlc. BacJzeAla an UALUACA Ae. fAeφiently. by. one. μeAaon to anotheA by. *dkln cσntaat and <z4μe> xz_lly. by. the. tAamfeA of bacteAlxi on the. - h n of the. μalnva and flngeA . Thl l< an exreA pA a αi A A n hσ-μ aLό w eAe. doctoAa and miAalng -όtaff sh u d contAsuiaLly. clzan&e. heAΛ handό when dealing, talth μatlen ό. ftoiaej/eA th-lό fAequeJitly. do&ύ not σocuA, vahetJveA foA >%e&Λon-i of fxt geAjfuLl A * . OΛ. of. time., and t-heAnfoAe. the. A ύ Of. UiafeAA fjZXJlo Λ*ZIϊLθlnd. A pΛe.paΛaz ύin IA AeψuzlAexL which onώ-inzό a aι c_Λoblc Lai agent talth the. convenience, of long-acting ΛUAf e. aεJzlon, theAeMy. affoAding the. minimum. nwnbeA of aμμl Um a A oueA a μeΛlod o-f. t me. In oAdeA to σσeAcσme. the. human pAobtMi ό-mOc i jl wit the. Δμ &d. o-f. -i fctio -in thl manneA. Qt haΛ be.en -όhouin that meAe. ΔuAface. clexmlng of. the. .f deAtnCΛ l* eJ_fex_t_ve. only. foA a ΛhoAt μeAlad because. Hiring Ag nAmΛ which -inhabit the. e.μlxieAB_al I teAόtl eA aAe. constantly. Aid g to the. * -UAfatz.e. theA of. IhuΛ any. Δ A χz.e. aμμllcatlon of jiuAf-u-e. actlzue. agen , axΛjεA ΛAeΛ , f n lΛxLejό and ant -t/lAal dΛj±A can only. exeAt tejtψaAaAy. axzztlon b foAe. lxi ml g <x.e-mav*zΛ thes T lύ Inirentlσn 4e..b& to μAoυlde. μte.μaAatlσn foA toμlcal aμμllcjatlon uheAe i the. ie^eπ of the. actAjje. agn * lit the. e.μldeAml>m usllTL be. ntoAe. difficult to dlΔp& .. OMPI "?HAj.rιwcεuj-icA p)zερa/ 30fi" The. Inυejitlon la de÷ύcAlbeΛ. In the. foH.ovljιg itatezment: - ' O Thla Invention pAovld&a a μhaAmajceutlcal pAe.paAatlon fa/% toμlcal application to the. ak n cotiφAlalng a geAmJjcljztally. effective. <zμtantlty. of -Iodine. In a combined foAm. and an agen foΛ. pAσaiσtlng the. abaoAμtlon and dlaμeAaal of the. latteA In the. e-μldeAn Δ_ TAezfeAaJhly. the, Iodine, la eXjestental odine. In poluvlnylpyAAolldone,. SlpillaAly. μolymeAlc auaμ nalana of odine. aAe. expected to be. exμi lly. effex-t ve., Thla component of the. pAe.paAatlon mazy. be. pA ^ aa a 10-15% aqueaua aolwtlon. The. exL &n foA μAomatlng dlaμ&Aaal of the. Iodine, and Ita abaoAμttσn may. be. fiyaluAon daάe. oA an oAgajιo-he.μaAlnold, A quantity, of loweA than T% of thla ^ψn . a fflcza £0 give, aatlafactoAy. μeneJzAatlxjn of the. Iodine.. An example, of an oAgano- h&poAlnold la a -lucσμolyaaccaAlde. μolyaulμhuAlxz. a id e^te , ■ 3n addition theAe. may. be. an agent to Aexiuce. the. ataJ ilng tend ncy. of the. odine., 3n one. example, of the. Invention a ama L quantity, of a 0,5% aσlutlσn of hyaluAonldaae, la added to a 2^_*% aqueoua aolutlon of Povldone.-3odlne. {K.e-g ateAed jAo . fllaAk wh ch * a commonly. available, foAm. of Iodine, combined with μalψrJj y μψiAoi done., Thla aolutlon lά. dlaμeAΛed n a atandaAd hand cAexm. fo-funu atlon, that la of the. vanlahlng type.. The. action of the. cAexm. aoftena the. ho-tny. X LψzJL of <Λe epldeAmla while, the. hyaluAonldaae, pAamot a the. pen&tAatlon of the. Iodine., dlaaσlvlng to a amal , extent the. connective, tlaaue. which la dlAexzΛly. beneath the, hoAny. JbaueA. -BUREAU OMPI T la pAe.paAatlan theAefoAe. eAmΛΛ* the. uae. of element Iodine, aa a mlxzAobl ide. without haAmful e ^ ffecta on the. uaeA, wh the, όc c;t of Its action la mpAoved by. Ita pen&tAatlan below the, akin* a auAface., both n eAma of e * ffexzJLluen&aa oveA time, an by. vlAtue. of Ita action agalnat aub-e.plthellal aAxzAobe*, Because, of the. falluΛe. of μeAaonnel. d&allng with Infectlaua OA Infective. mateAlx . and envAonm&nta to aat afaxzto cleanae. thelA hands, the. pAable . of Initiation and tAanafeA of Infection exlata. Th s pAe.μaΛatlσn cateAa foA thla pAoble . by. pAovldlng a method of μeAhpa once, a day. application of an antlae.ρtlc known to be. eflfectlυe. agalnat bacteAla n geneAal, fungua&a, yeaata, vlAua&a and vejgetxitlzve. oAganlama. T π nimlaation of the. numbeA of t m * a pAe.μaAatlon of thla type, AexμxlAed to be. applied, will. catcA foA the. falluAe. to cleanse. hand* foA any. Λeaaσn, and hsA-foA. Aeduce. tAanafeA of Infectio In thla manneA, -BU O

Claims: The clal a de-tlning the. Invention aAe. aa fσllowa: - (1) Becauae. of Ita foAmulatlon, namely the. combination of the, polyirlnylpyλAolldone foAm. of e -emental Iodine and a t sane dlspeAaant agent, hyalMAσnldaae. oA an oAgano-heμaAlnold, the. pAepoA mtlon wilt be. aba a Abed Into th cpldeAsnl , a function not peAmfoJimed by. any. otheA ajvallxible. antla&ptlc oA dlalnfectlng pA μaAatlon, (2) Becauae, It la abaσAbed Into th e,μldeAmla the antiae.ptlc and dlalnfexz nq. action of the, pAepaAaJtlan la In f ec pAolanged oveA a peΛlod of time not pAezaentϋj. poaalble by. any. otheA antlae.μtlc OA disinfecting agent, (3) Becauae, It la aJbaoAbed Into the. e-pldeAmts and poaalbly. (to a leaaeΛ. extent) Into the. deΛmls, the pAcpoAatlon will act against Aealdent mlcAσ-oAgan sma, which would otheAwlse. Alae, to -the. auAfac of the akin, theAehy. caualng Ae.-conΛxLmlnat an. Thla aub-e.plthellal antlae.ptlc and/oA dlalnfecting action la not poaalble with pAesently. available pA&paAatlons,

Inventors: HARRIGAN P
Applicants: HARRIGAN P
Application year: 1980
Main classification: A61K33
IPC codes: A61K9, A61K33, A61K38, A61K47