2,3-DIALKOXY-1,4-QUINONE DERIVATIVES; METHOD OF PRODUCING 1,4-QUINONE DERIVATIVES

Abstract: A compound of the general formula: wherein m is an integer of 10 to 21; R₁ is lower alkyl having 1 to 4 carbon atoms; B is a -CH₂- or -CO- group, when B is -CH₂-, R₂ is hydrogen, lower alkyl having 1 to 4 carbon atoms or lower acyl having 1 to 8 carbon atoms, and when B is -CO-, R₂ is hydrogen or lower alkyl having 1 to 4 carbon atoms, has pharmaceutical activities such as hypotensive, tissue metabolism stimulating, immunoregulatory, lysosomal membrane stablizing and SRS-A production inhibitory activities and is useful as a heart failure remedy, cerebral circulation disturbance remedy, immunoregulator and antiallergic drug. A compound of the general formula: [wherein each R₃ is lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, or two R₃'s taken together represent -CH=CH-CH=CH-; n is 0 or an integer of 1 to 20 and when n is 1 to 20, A is -CH₂-, -- or -CO- and Z is CH₂OH, acyloxymethyl having 2 to 11 carbon atoms, esterified or unesterified carboxyl having 1 to 5 carbon atoms, lower alkoxymethyl having 2 to 5 carbon atoms,

Description: Quinone Derivatives and Method for Production Thereof. This invention relates to new quinone compounds of value as medicines and to a novel method for producing quinone compounds. Ubiquinones are effective against heart failure, periodontal disease, diabetes, muscular dystrophy, asthma, etc. but because they are generally low in water solubility, the route of administrntion is limited and the onset of action is not satisfactory. The research undertaken by us has resulted in the fin(iing of new quinone compounds which possess desirable pharmacological activities and a novel method for producing a quinone compound, which is advantageous from the industrial point of view. One aspect of the present invention relates to a compound of the general formula: EMI1.1 wherein m is an integer of 10 to 21; nl is lower alkyl having 1 to 4 carbon atoms; B is a -CH2- or -CO- group; when B is CH2-, R2 is hydrogen, lower alkyl having 1 to 4 carbon atones or lower acyl having 1 to 8 carbon atoms, and when B is -CO-, R2 is hydrogen or lower alkyl having 1 to.4 carbon atoms. In the above formula (I), the lower alkyl designated by R1 or R2 is one having 1 to 4 carbon atoms, such as methyl, ethyl, n-propyl, n-butyl, etc. The lower acyl designated by R2 is one having 1 to Q carbon atoms. As embodiments of the lower acyl R,, tere are mentioned aliphatic acyl (e.g. formyl, acetyl, poionyl, butyryl, etc.), aromatoaliphatic acyl (e.g. phellyla(etyl, etc.) and aromatic acyl (e.g. benzoyl, etc.). The integer m is preferably 10 to 17. The present compound of the general formula (I) has the physiological activity of ubiquinones and, when the mitochondrial electron-transport activity of (I) was assayed by the general method for assaying the physiological activity of ubiquinones, it was found to display a marked degree of activity as shown in Table 1. Table 1 Electron-transport activity of the present compound Level of Succinate oxidase activity addition addition [oxygen consumption per mg Compound (n moles) enzyme protein during 1 minute (n atoms)] Control 0 19.34 + 1.42 [In formula I) 10 96.05 m: 12 B : CH3 R2: H : CO [In formula I] 10 146.10 m: 12 R1: CH) R2: CH3 31 CO [In formula I] 10 112.05 m: 12 R1: CH3 R2: H B CO 2 1) Ubiquinone-depleted enzyme preparations were prepared in accordance with Lester and Fleischer (Biochem. Biophys. Acta.,47, 358-377, 1961). The electron-transport activity was determined based on succinate oxidase activity. Furthermore, we investigated the effect of the present compound (I) on the production and release of the slow reacting substance of anaphylaxis (hereinafter, SRS-A) which has been mentioned as a main factor in asthma. Thus, in accordance with the method of Orange and Moore (J. Immunol., 116.,392-397, 1976), the present compound (I) was added to guinea-pig lung fragments sensitized with egg albumin as the antigen, and the amount of SRS-A produced and released as a consequence was assayed by the method of Brocklehurst (J. Physiol.,151, 416-435, 1960), It was found that, as shown in ale 2, the present compound displayed a very patent inhibitory action on SRS-A production at low concentration. Table 2 The inhibitory effect of the present compound on SRS-A production Compound 1) Concentration Inhibitory effect@@ ( M) SRS-A production 2) : [In formula I] R1: CH3, B: CO 1 60.0 + 3.3 R2: H, m: 12 10 87.2 + 5.5 Ri: CH3, B: CO R2: H, m: 17 10 82.8 + R1: CH3, B: CO R2: H, m: 21 10 80.5 + 0.5 1) The compound was added as dissolved in ethanol or dimethyl sulphoxide. 2) The inhibitory effect on SRS-A production was expressed as the % inhibition of production and release of SRS-A. The present compound (I) has hotensive, tissue metabolism-stimulating, immuno-regulatory, lysosomal membrane-stabilizing and SRA-A production inhibitory activities and is used as a heart failure remedy, cerebral circulation disturbance remedy, immono-regulator, antiallergic drug (for the treatment of e.g. asthma, rhinitis, etc.), etc. for mammalian animals including human beings. Useful dosage forms include capsules, granules, powders, tablets, troches, pills, syrups, injections, suppositories, etc. As an antiallergic drugs, dosage forms such as ointment, aerosol, inhalation mist, etc. may be employed. The pharmaceutically acceptable materials which can be used in formulating pharmaceutical- preparations include, among others, excipients such as sucrose, lactose, glucose, starch, mannitol, sorbitol, cellulose, talc, cyclodextrin, etc.; binders such as cellulose, methylcellulose, polyvinyl pyrrolidone, gelatin, gum arabic, polyethylene glycol, sucrose, starch, etc.; disintegrators such as starch, carboxymethylcellulose, carboxymethylcellulose calcium salt, etc.; lubricants such as talc; flavourants; preservatives such as sodium benzoate; suspending agents such as methylcellulose, polyvinyl pyrroli done, aluminium stearate, Polysorbate 80, Emalgen 408, Emasol 310, etc., solvents such as water, and pharmaceutical bases such as cacao butter, polyethylene glycol, witepsol, white petrolatum, etc. These materials are selectively used according to te type of pharmaceutical preparation. The compound (I) of this invention is administered orally or otherwise, preferably at doses of 5 to 500 mg daily (0.1 to 10 mg/kg) for adult humans, for instance. The other aspect of the present invention relates to a method of producing a quinone derivative of the general formula: EMI4.1 wherein each B3 is lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, or two B3ft-aken together represent -CH=CH-CH=CH-; n is O or an integer of 1 to 20 and when n is 1 to 20, A is C112, EMI4.2 or -CO- and Z is hydroxymethyl, acyloxymethyl having 2 to 11 carbon atoms, esterified or unesterified carboxyl having 1 to 5 carbon atoms, lower alkoxymethyl having 2 to 5 carbon atoms, silyloxymethyl having 4 to 7 carbon atoms or acetalmethyl having 3 to B carbon atoms; when n is 0, -A-(CH2)n-Z is EMI4.3 (wherein 1 is O or an integer of 1 to 12) and Z is II, which method comprises oxidizing a compound of the general formula: EMI5.1 wherein either Xllis hydroxyl or amino, with the other being H or an esterified hydroxyl group having 1 to 8 carbon atoms or etherified hydroxyl group having 2 to 8 carbon atoms; the other symbols are as defined above, with oxygen or air in the presence of a transition metal complex compound. It is known that a quinone derivative of general formula (ii) can be obtained by Oxidizillg a compound of general formula (III) with an oxidizing agent such as hydrogen peroxide, peracetic acid, performic acid, potassium dichromate, potassium permanganate, chromic anhydride, potassium nitrosodisulphate, potassium persulphate and so on. However, when an oxidizing agent such as those mentioned above is employed, the desired compounds can be obtained only in low yield and the byproducts are produced in large amounts so that the desired compounds are hardly of high purity. Moreover, using the above-mentioned oxidizing agents in large amounts is not desirable from the safety point of view. Thus, the conventional processes are not suited for commercial production purposes. In contrast, the method of this invention employs a complex compound, preferably of cobalt, and yields the desired compounds in good yield and purity, thus being very advantageous for commercialscale production. Referring to the above general formulae (II) and (III), the lower alkyl group R3 may be n straigllt-chain or branched alkyl group containing 1 to 4 carbon atoms each, such as methyl, ethyl, n-propyl, 1-propyl, n-butyl, i-butyl, etc. The alkoxy group, also designated by R3, may be a group of 1 to 4 carbon atoms, such as methoxy, ethoxy, n-propoxy, n-butoxy, etc. The symbol n is O or an integer of 1 to 20, preferably, 0 or 10 to 20, and most preferably 13 to 20. The symbol 1 is O or an integer of 1 to 12 and preferably 5 to 12. The lower acyloxymethyl group Z is one having 2 to 11 carbon atoms, and may be an alkylcarbonyloxymethyl group of 3 to 6 carbon atoms, preferably of 3 to 5 carbon atoms, e.g. acetyloxymethyl, n-propionvloxBTmethylS butyryloxymethyl etc.; an arylcarbonyloxymethyl group of 8 or 9 carbon atoms, e.g. phenylcarbonyloxymethyl, p-methylphenylcarbonyloxymethyl, etc.; or an aralkyl carbonyloxyinethyl group of 9 to 11 carbon atoms, e.g. benzylcarbonyloxymethyl, phenethylcarbonyloxymethyl etc. The optionally esterified carboxyl group Z may, for example, be a free carboxyl group or an alkoxycarbonyl group of 2 to 5 carbon atoms, e.g. methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, n-butoxycarbonyl, etc. The lower alkoxymethyl group Z may be a group of 2 to 5 carbon atoms, e.g. methoxymethyl, ethoxymethyl, n-propoxymethyl, n-butoxymethyl, etc. The silyloxy methyl group Z may be a group having 4 to 7 carbon atoms, e.g. trimethylsilyloxymethyl, t-butyldimethylsilyloxymethyl, etc The acetalmethyl group Z may be a group having 3 to 8 carbon atoms e.g. tetrahydropyranyloxymethyl, tetrahydrofuranyloxymethyl, methoxymethyloxymethyl, methylthiomethyloxymethyl, etc. The esterified or etherified hydroxyl group, which is designated by X1 or X2, may for example be an acyloxy group, such as alkylcarbonyloxy groups of 2 to 6 carbon atoms, preferably of 2 to 4 carbon atoms (e.g. acetyloxy, propionyloxy, butyryloxy, etc.), arylcarbonyloxy groups having 6 to 8 carbon atoms (e.g. benzoyloxy), etc., tetrahydropyranyl oxy, tetrahydrofuranyloxy, alkoxyalkyloxy groups having 2 to 8 carbon atoms such as methoxymethyloxy, 2-methoxyethyloxy, etc., silyloxy groups having 3 to 6 carbon atoms such as trimethylsilyloxy, t-butyldimethylsilyloxy, etc. The oxidation reaction according to this invention is carried out by catalytic oxidation with oxygen, air or the like in the presence of a transition metal complex compound. The transition metal complex compound is a complex compound which-is able to yield an oxygen complex compound reversibly on interaction with oxygen, such as the complex compounds of iron, cobalt, nickel, copper, etc. although complex compounds of cobalt are particularly desirable. Of such complex compounds of cobalt, compounds respresented by the following general formula are preferred. EMI7.1 [wherein D is a vinylene group of EMI7.2 is lower alkyl or phenyl) ar an orthophenylene group of EMI7.3 (R5 is H, hydroxy or lower alkoxy); E is H or lower alkyl; G is an ethylene group of EMI7.4 (R6 is 11 or lower alkyl) or an orthophenylene group of EMI7.5 ill'he lower alkyl groups K4' K6 and E are ones having 1 or 2 carbon atoms, e.g. methyl, ethyl, etc.; the lower alkoxy group R5 is one having 1 or 2 carbon atoms and may for example be methoxy or ethoxy. As examples of compounds having the above general formula (IV), there may be mentioned divalent cobalt-Schiff's base complexes such as cobalt salen (salcomine), cobalt salpr, cobalt, salphen, cobalt acacen, cobalt bzacen and other compounds such as bis(3-alkoxysalicylidene) ethylenediiminocobalt(II), bis(4-hydroxysalicylidene) ethylenediiminocobalt(II), etc. This catalytic oxidation reaction is usually conducted in an organic solvent. The solvent includes, for example, halogenated hydrocarbons such as dichloromethane, 1,2-dichloroethane, 1,1,2,2-tetrachloroethane, chloroform, carbon tetrachloride, etc.; lower alcoholtype organic solvents such as methanol, ethanol, butanol, etc.; amide-type solvents such as dimethylformamide, dimethylacetamide, hexamethylphosphorotriamide, etc.; pyridine and substituted pyridine (e.g. s-collidine), dimethylsulphoxide, sulpholane, etc. These organic solvents can be used as a mixture of taço or more species. The amount of metal complex compound used in accordance with this invention should vary with the type of substrate compound and other conditions of reaction. Usually, the complex compound is used in a range of from 0.01 to 50 weight percent relative to compound (III) and, preferably, 1 to 30 weight percent on the same basis. The oxidation reaction with the aid of this complex compound is promoted by te addition of imidazole, pyridine or cyanide, ions (e.g. sodium cyanide). The amount of such an additive is preferably the same as that of the transition metal complex. The reaction temperature is normally in the range of from OOC to 800C an, preferably, room temp era- ture. This reaction may be conducted at atmospheric pressure and, optionally, at an elevated pressure not over 150 atm. The reaction time may range from 0.5 hours to 30 days, normally up to 75 hours. After the oxidation reaction, the product compound can be easily isolated and purified by procedures known per se (e.g. extraction, concentration, recrystallization, chromatography, etc.). The compound (I) can be prepared by oxidizing the compound (III) wherein R3 is alkoxy; A is -CIIZ-; Z is hydroxylmethyl, alkoxymethyl, acyloxymethyl, carboxyl or alkoxycarbonyl, and n is an integer of 9 to 20. The starting compound (III) used in the practice of the present invention can be produced, for example, by the method described in US Patent No, 4,139,545 or a method analogous thereto. The compound (III) can also be produced through the following steps. EMI9.1 In the above formuiae, each symbol is as defined hereinbefore. The invention is illustrated by tbo following Examples. Example 1 11.7 g of methyl l3-chloroformyltridecanoate are dissolved in 200 ml of petroleum ether and, under ice-cooling and stirring, 60 ml of ice-water are added, followed by addition of 5.2 of sodium peroxide in small portions. The mixture is stirred for an hour, at the end of which time it is extracted with ether. The extract is washed with water and dried over calcium chloride,and the solvent is distilled off under reduced pressure. The above procedure yields 7.6 g of crude crystals of bis-13-methoxyearbonyl- trideconoyl peroxide. This product is subjected to the next reaction without being purified. IRç filmcml: max 1790, 1760 EMI10.1 1730(COOCH3). 1.7 g of 2,3dimethoxy-5-methyl-l,4-benzoquinone arc dissolved in 20 ml of acetic acid and, under stirring at 9000, 7.6 g of bis-13-methoxyearbonyltridecanoyl peroxide are added in small portions. The mixture is heated for 22 hours and, after cooling, is diluted with water and extracted with ether. The extract is washed with a saturated aqueous solution of sodium chloride, aqueous sodium hydrogen carbonate and aqueous sodium chloride in that order, followed by drying. The solvent is distilled off under reduced pressure and the residue is recrystallized from hexane to obtain 1.37 g of 2,3-dimethoxy-6-(12- methoxyearbonyldodecyl)-5-methyl-1,4-benzoquinone. m.p. 54 C. Elemental analysis for C23H3606 Calcd. C, 67.62; H, 8.88 Found C,67.52; H, 8.59 Example 2 1.5 g of 2, 3-dimethoxy-6-(l2-methoxyarbonyldodecyl)- 5-methyl-1,4-benzoquinone are dissolved in 200 ml of ether, and the solution is shaken with 75 ml of a 20 aqueous solution of sodium hydrosulphite. The ether layer is separated and concentrated. To tlic residue are added, under ice-cooling and in a nitrogen gas stream, 5 ml of a 30% aqueous solution of sodium hydrosulphite an 3.5 ml of a 30% aqueous solution of potassium hydroxide. The mixture is 7armed at 50 C for 2.5 hours. After cooling, the reaction mixture is made acidic with cold hydrochloric acid and extracted with ether. The ether is distilled off under reduced pressure, the residue is dissolved in 75 ml of methanol and a solution of 15 g o ferric chloride in 60 ml of water is added. The mixture is stirred at room temperature for 1 hour, at the end of which time it is diluted with water and extracted with ethyl acetate. The extract is washed with water and dried, and the solvent is distilled off under reduced pressure. The residue is crystallized from ether-hexane to obtain 1.09 g of 6-(12-carboxydodecyl)-2,3-dimethoxy-5-methyl-1, 4-benzoquinone. m.p. 620C. Elemental analysis for C22113406 Calcd. C,66.98; H, 8.69 Found C,67.15; H, 8.77 Example 3 (a) 1 g of monomethyl 1,20-eicosanedicarboxylate is dissolved in 5 ml of thionyl chloride, and after stirring at room temperature for 12 hours, the excess thionyl chloride is distilled off to recover crude crystals of methyl 21-chl oroformylheneicosanoai; e. Tllis product is subjected to the next reaction without being purified. IR # KBr cm-1 1790(cOCl), 1730(C00CHS max 8 g of methyl 21-chloroformylheneicosanoate arc dissolved in 60 ml of 1, 2-dichloroethaiic followed by addition of 5.5 g of aluminium chloride. The mixture is stirred. Then, under ice-cooling and stirring in a nitrogen stream, a solution of 5.G7 g of 3,'i,5-trimethoxytoliiene in 1,2dichloroethanc (13 ml) is added dropwise. The mixture is stirred for 48 1ioirs, after which 1.3 g of aluminium chloride is added The mixture is stirred nt room temperature for 16 hours and further at 35 C-38 C for 40 minutes. To this reaction mixture arc added ice-water and 3N-C1, followed by extraction with chloroform. The extract is washed with water, a saturated aqueous solution-of sodium hydrogen carbonate and water in that order. After drying, the solvent is distilled off under reduced pressure and the residue is chromatographed on silica gel. The fractions containing the desired compound are pooled and recrystallized from methanol. The above procedure yields methyl 212-hydroxy-3,4-dimethoxy-6-methylbenzoyl)heneicosanoate as colourless needles. m.p. 73-74 C. NMR( #, in deuteriochloroform): 1.24(36H, b, CH2), 2.27(2H,t, CH2COO), 2.42(311,s,nuclear CH3), 2,86(2H,t,COCH2), 3.64(3H,s,COOCH3), 3,84(3H,s,OCH3), 3.87(3H,s,OCH3), 6.22(1H,s,nuclear H) Perchloric acid is added to a solution of methyl 21- (2-hydroxy-3, 4-dimethoxy-6-methylbenzoyl )heneicosanoate in acetic acid and catalytic reduction is carried out with 5 palladium-On-carbon. palladium-On-carbon. The reaction mixture is worked up as in the corresponding step of Example 5 and the resultant product is recrystallized from ethanol. The above procedure yields methyl 22-(2-hydroxy-3,4-dimethoxy-6- methylphenyl)-docosanoate as colourless needles, m.p. 71 C-72.5 C, 300 mg of methyl 22-(2-hydroxy-3,4-dimethoxy- 6-methylphenyl)docosanoate followed by addition of 20 ml of a 14% aqueous solution of sodium hydroxide. The mixture is stirred at 50 C-60 C for 1.5 hours. The reaction mixture is made acidic with 3N C1 and extracted with ethyl acetate. The extract is washed with water and, after drying, the solvent is distilled off under reduced pressure. The residue is recrystallized from methanol to obtain 22-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)- docosanoic acid. m.p. 67 C-68 C. b) In the presence of triethylamine (]/1.3 ml), 6-(9-chloroformylnonyl)-2,3-dimethoxy-5-methylphenyl acetate (36.9 g) is reacted with l-morpholino-l cyclododecene (24.3 g) as in the eorresponding step of Example 6. The reaction product is treated with 6N-EC1 (47 ml) and the resultant 2-[10-(2-aeetoxy-3,4- dimethoxy-6-methylphenyl)-decanoyl] cyclododecanone (46.3 g) is hydrolyzed with a 6N-aqueous solution of sodium hydroxide to obtain 32.4 g of 13-oxo-22 (2-hydroxy-3,4-dimethoxy-6-methylphenyl)doeosanoie acid, m.p. 63 C-64 C. l3-Oxo-22- (2-hydroxy-3, 4-dimethoxy-6-methyl- phenyl)-docosanoic acid (5.21 g) is reduced in the presence of p-toluenesulphonic acid (250 mg) and ptoluenesulphonyl hydrazide (2.33 g) in a solvent mixture of dimethylformamide (25 ml)-sulpholane(25 ml)-cyclohexane(25 ml) as in the corresponding step of Reference Example 6. The resultant crude product is recrystallized from methanol to obtain 9. 97 g of 22-(2-hydrosar-3,4-dimethoxy-6-methylphenyl)docosanoie acid, m.p. 67 C-68 C. The physico-chemical constants of this product are all in agreement with those of the crystals obtained in the above step a). To a solution of 300 mg of 22-(2-hydroxy-3,4dimethoxy-6-methylphenyl)docosanoic acid in 20 ml of N,N-dimethylformamide are added 50 mg of bis(salicylidene)ethylenediiminocobalt (II) and the mixture is stirred in an oxygen gas stream at room temperature for 24 hours. The insolubles are filtered off and the filtrate is concentrated under reduced pressure. The residue is dissolved in ethyl acetate, washed with water and dried. The solvent is distilled off and the residue is dissolved in chloroform and column-cliromatographed on silica gel, elution being carried out with chloroform. The eluate is recrystallized from ethanol to obtain 6-(21-carbosheneicosyl?-3,4-dimethozy-5-methyl-1, 4-benzoquinone as orange-yellow needles melting at 86 C-87 C. Elemental analysis for 031115206 Calcd. C,71.50; H, 10.07 Found C,71.56; H, 10.06 Example 4 Aluminium chloride (7 g) is added to a solution of 18-acetozy-n-octadecanoyl chloride (11 g) in 1,2dichloroethane (50 ml), and the mixture is stirred at room temperature for 2 hours. This reaction mixture is cooled to 50C and a solution of 3,4,5-trimethoxytoluene (6.2 g) in 1,2-dichloroethane (20 ml) is added. The mixture is stirred at room temperature for 72 hours. Then, this reaction mixture is heated to 500C-600C and stirred for 30 minutes. After cooling, ice-water is added to the reaction mixture and the product is extracted with dichloromethane. The dichloromethane layer is washed with water and the solvent is distilled off to recover an oil (12.1 g). This oil is dissolved in methanol (150 ml) followed by addition of sodium hydroxide (5.2 g). The mixture is stirred at room temperature for 2 hours, at the end of which time it is neutralized with 5N-HCl and the solvent is distilled off. The resultant crude crystals are rinsed with water and recrystallized from dichloromethane-ether (1:1). The above procedure yields 6-(18-hydroxy-l-ouooctadecyl)-2,- dimethoxy-5-methylphenol (6.4 g) as colourless needles, m.p. 101 C. 5k palladium-on-carbon (5070 hydrous)(0.5 g) and 70% perchloric acid (o.o5 ml) are added to a solution of 6-(l8-hydroxy-l-oxooctadecyl)-2, 3-dimethoxy-5- methylphenol (1.4 g) in acetic acid (30 ml) and catalytic reduction is carried out at atmospheric temperature and pressure. After the absorption of hydrogen has subsided, the catalyst is filtered off and the filtrate is concentra under reduced pressure, whereupon a colourless oil is obtained. This product is dissolved in either and the ether layer is washed with 5% aqueous solution of sodium hydrogen carbonate and dried over anhydrous sodium sulphate. The solvent is then distilled off and tlle re sultant crude crystals are recrystallized from hexane. The above procedure yields 6-(18-acetoxy- octadecyl)-2,3-dimethoxy-5-methylphenol (1.4 g) as colourless needles, m.p. 530C. The above 18-acetoxy compound was deacetylated by the corresponding procedure of Example 5 and the resultant 6-(18-hydroxyoctadecyl)-2,3-dimethoxy-5-methylphenol (0.5 g) is dissolved in dimethylformamide (1 1). To this solution is added potassium nitrosodisulphonate (13 g), 700 ml of water, 100 ml of methanol and monopotassium phosphate (1 g), and the mixture is stirred at room temperature for 45 days. The product is extracted in the conventional manner and recrystallized from ether-hexane. The above procedure yields 6-(18hydroxyoctadecyl)-2, 3-dimethoxy-5-methyl-l, 4benzoquinone as yellow needles (0.31 g), m.p. 81Or Elemental analysis for C27H4605 Calcd. C, 71.96; E, 10.29 Found C, 72.06; H, 10.27 172 mgof 6-(18-hydroxyoctadecyl)-2,3-dimethoxy-- 5-methyl-1,4-benzoquinonei are dissolved in 10 ml of acetone. Separately, 2.672 g of chromic anhydride are dissolved in 2.3 ml of concentrated sulphuric acid and diluted with water to 10 ml. This diluted solution (0.5 ml) is added to the above -acetone solution and the mixture is stirred under ice-cdoling for 10 minutes. The reaction mixture is diluted with water and extracted with chloroform. The extract is washed with water and dried, and the solvent is distilled off unddr reduced pressure. The residue is column-chromatographed on silica gel, elution is carried out with chloroform and the eluate is recrystallized from ethanol. The above procedure yields 65 mg of 6-(17-carboxyheptadecyl)-2,3-dimethoxy 5-methyl-l,4-benzoquinone as orange-yellow crystals, m.p. 77-79 C. Elemental analysis for C27II4406 Clod. C,69,79; H 9.55 Found C,69.86; H 9.78 Example 5 Aluminium chloride (28 g) is added to a solution of ll-acetoxy-n-undecanoyl chloride (27.6 g) in 1,2-dichloroethane (150 ml), and the mixture is stirred at room temperature for 2 hours. The reaction mixture is cooled to 5 C and, then, a solution of 3,4,5-trimethoxytoluene (19.1 g) in 1,2-dichloroethane (50 ml) is added. The mixture is stirred at room temperature for 72 hours. The reaction mixture is heated to 50 C-60 C and further stirred for 30 minutes. After cooling, 300 ml of ice-water are added to the reaction mixture and the product is extracted with dichloromethane. The dichloromethane layer is washed with water and dried over anhydrous magnesium sulphate. The solvent is then distilled off to recover 6-(llacetoxy-1-oxoundecyl)-2,3-dimethoxy-5-methylphenol Neat (35 g). IRv max cm-1: 1730(OAc), 1680(Co), 1610, 1580(Ar). MS m/e: 394(M+), 352, 334, 195 Sodium hydroxide (7 g) is added to a solution of 6-(11- cetoxy-1-oxoundecyl)-2,3-dimethos?-5-methylphenol (34 g) in methanol (300 ml) and the mixture is stirred at room temperature for 2 hours. The reaction mixture is neutralized with 5N-HC1 and the solvent is distilled off, thereby leaving crude crystals. These crystals are rinsed with water and recrystallized from etherhexane (1:1). The above procedure yields colourless needles of 6-(11-hydroxy-1-oxoundecyl)-2,3-dimethoxy-5- methylphenol (30 g), m.p. 81 C. 5% palladium-on-carbon (50 hydrous) (3 g) and 70% perchloric acid (0.1 ml) are added to a solution of 6-(11-hydroxy-1-oxoundecyl)-2,3-dimethox-5-methyl- phenol (14 g) in acetic acid (200 ml), and catalytic reduction is carried out at atmospheric temperature and pressure. When the hydrogen has ceased to' be absorbed, the catalyst is filtered off and the filtrate is concentrated under reduced pressure. The residue is extracted with dichloromethane and the dichloromethane layer is washed with a 5% aqueous solution of sodium hydrogen carbonate and dried over anhydrous magnesium sulphate. The solvent is then distilled off to obtain a colourless oil of 6-(ll-acetoxyundecyl)-2,3-dimethoxy5-methylphenol (15 g). IR#Neat/maxcm-l: 3450(011, 1730(0Ac), 1610, 1580(Ar). NMRs ppCl54 1.1-1.9[18H,m,-(CH2)9-], ppm 2.02(3H,s,)Ac), 2.22(3H,s,C5-CH3), 2.54(2H,t,J=7Hz, C1 112), 3.79(3H,s,OCH3), 3.83(3H,s,OCH), 4.01(2H,t,J= 6Hz, the OAc), 5.78(1H,s,C1-OH), 6.23(1H,s,C4-H). MS m/e:380(M+), 338, 181. Potassium nitrosodisulphonate (24 g), water (400 ml), methanol (30 ml) and monopotassium phosphate (1.0 g) are added to a solution of 6-(ll-acetozyundecyl)- 2,3-dimethoxy-5-methylphenol (8 g) in N,N-dimethylformamide (400 ml). The mixture is stirred at room temperature for 28 days. The product is extracted Tsith dichloromethane and the dichloromethane layer is washed with water and dried over anhydrous magnesium sulphate. The solvent is then distilled off and the resultant crude crystals are recrystallized from hexane. The above procedure yields 6-(11-acetoxyundecyl)-2,3-dimethoxy-5-methrl-1,4-benzo- quinone (6.4 g) as orange-yellow needles, m.p. 4100. To a solution of 6-(ll-acetoxyundecyl)-2,-dimethoxy- 5-methyl-1,4-benzoquinone (4.2 g) in methanol(200 ml) is added concentrated hydrochloric acid (0.1 mi) and the mixture is allowed to stand at room temperature for 12 hours. Sodium hydrogen carbonate (0.2 g) is added to the reactipn mixture and the-solvent is distilled off. The product is dissolved in dichloromethane, the insolubles are filtered off and the dichloromethane is distilled off. Tile resultant crude crystals are recrystallized from hexane-etlier (3:1) to obtain 6-(11-hydroxyundecyl)- 2,3-dimethoxy-5-methyl-1,4-benzoquinone as orange-coloured needles (3.6 g), m.p. 5700. 6-(11-Hydroxyundecyl)-2,3-dimethoxy-5- methyl-l,4-benzoquinone is reacted in tlic same manner as in Example 4 and the product is purified by silica gel column chromatography to recover orange-yellow needles of 6-(10-carboxydecyl)-2,3-dimethoxy-5 methyl-1,4-benzoquinone. m.p. 50 C-52 C. NMR (s, in deuteriochlorofnrm): 1.32(16H,b,CH2), 2.03(3H,s,CE3), 2.18-2.65(4H,m,CH2COO,CH2 on the ring), 4.02(6H,s,oCH3), 5.35(1H,b,COOH). Example 6 10-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)- decanoic acid (33.8 g) is suspended in acetic anhydride (100 ml) followed by addition of concentrated sulphuric acid (5 ml). The mixture is reacted at room temperature for 1.5 hours, at the end of which time the solvent is distilled off. To the residue are added dioxane (250 ml) and a 5% aqueous solution of sodium hydrogen carbonate (250 ml), and the mixture is stirred at room temperature for 24 hours. The reaction mixture is adjusted to pil 3 with 7N-HC1 and extracted by the addition of ethyl acetate (300 ml) and water (500 ml). The ethyl acetate layer is washed with water and dried over anhydrous sodium sulphate. The solvent is distilled off to recover 36.2 g of 10-(2-acetoxy-3,4-dimethoxy-methylphenyl)deca- noic acid as an oil. This oil is dissolved in anhydrous benzene (50 ml) and, under ice-cooling, oxalyl chloride (25 ml) is added dropwise. Following the dropwise addition and after bubbles have subsided, the reaction is allowed to proceed at 50 C for an hour. The solvent is then distilled off, toluene is added and the solvent is distilled off under reduced pressure. The residue is dried over sodium hydroxide in a desiccator to obtain 36.9 g of 6-(9-chloroformylnonyl)-2,3-dimethoxy- 5-methylphenyl acetate. NMR (, in deuteriochloroform): 1.33 (14H,b,CH2), 2.33, 2.37(6H,s,COCH3,nuclear CH3), 2.95(4H,t,CH2CO, nuclear CH2), 3.87, 3.90(6H,s,OCE3) 6.73(1H,s,nuclear H). IR# film cm-1: 1800(0001), 3 max 1770(OCOCH3). 6-(9-chloroformylnonyl)-2,3-dimethoxy-5-meth t phenyl acetate (5.0 g) is dissolved in chloroform (4 ml), and under ice-cooling, the solution is added dropwise to a mixture of l-morpholino-l-cyclohexene (2.51 g) and triethylamine (1.93 ml). After the dropwise addition has been completed, the reaction is allowed to proceed at room temperature for 90 hours. To this reaction mixture is added 6N-hydrochloric acid (7.5 ml), ad with vigorous stirring, the mixture is refluxed for 5 hours. The mixture is subjected to extraction by the addition of chloroform (20 ml) and water (20 ml). The water layer is further extracted with chloroform (20 ml) and the chloroform layers are combined, washed with water and dried over anhydrous sodium sulphate. The solvent is distilled off and the residue is dissolved again in chloroform and subjected to chromatography on silica gel (60 g), elution being carried out with chloroform. The fractions containing the desired compound are pooled and the solvent is distilled off to obtain 3.2 g of 2-[10-(2-acetoxy- 3,4-dimethoxy-6-methylphenyl)decanoyl]cyclohexanone as an oil. This oil is dissolved in ethanol (3.5 ml) followed by addition of a hot 6N-aqueous solution of sodium hydroxide (3.5 ml). The mixture is heated under reflux for 10 minutes. Then, at room temperature, the reaction mixture is adjusted to pH 2 with 6N-RCl, follow ed by extraction by the addition of ethyl acetate (30 ml) and water (3o ml). The water layer is further extracted wtth ethyl acetate (10 ml) and the ethyl acetate layers are combined, washed with water and dried over anhydrous sodium sulphate. The solvent is distilled off and the residue is recrystallized from ether-petroleum ether. The above procedure yields, 1.96 g of 7-oxo-l6-(2-hydroxy 3,4-dimethoxy-6-methylphenyl)hexadecanoic acid, m.p. 55-57 C. To a solvent mixture of dimethylfonnamide (10 ml) and sulpholane (10 ml) containing p-toluenesuiphonic acid (100 mg) is added 7-oxo-16-(2-hydroxy-3,4 dimethoxy-6-methylphenyl) hexadecanoic s (1.75 g) and p-toluenesulphonyl hydrazide (930 mg) at 100 C. After 5 minutes, cyclohexane (10 ml) and Odium cyanoborohydride (1.0 g) are added. The reaction is conducted at 100 C for 20 minutes. The, at room temperature, a saturated aqueous solution of sodium chloride (100 ml) is added, followed b extraction with ether (50 ml x 2). The ether layers are combined, washed ith water, 1N- BC1 and water in that order, and dried over anhydrous sodium sulphate. The solvent is distilled off, and the residue is dissolved in chloroform and subjected to column chromatography on silica gel, elution being carried out with chloroform. The fractions containing the desired compound are pooled and the solvent is distilled off. To the crystalline residue is added petroleum ether and, after cooling, the crystals are collected by filtration. The above procedure yields 970 mg of 16-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)- hexadecanoic acid, m.p. 450C-460C. 16-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)- hexadecanoic acid (844 mg) is dissolved in dimethylformamide (20 ml), followed by addition of bis(salicylidene)ethylenediiminocobalt (II) (163 mg). The mixture is stirred in-a stream of oxygen gas at room temperature for 24 hours. The solvent is distilled off, the residue is dissolved in ethyl acetate (100 ml) and the insolubles are-filtered off. The filtrate is washed with lN-Hl and water and dried over anhydrous sodium sulphate. The solvent is distilled off and the residue is dissolved in a small amount of chloroform and purified by column chromatography on silica gel (20 g) with chloroform as the eluent. The fractions containing the product compound are pooled, the solvent is distilled off and the residue is recrystallized from çther-petroleum ether to obtain 514 mg of 6-(15-carboxypentadecyl)-2, 3-dmethoxy-5-methyl-l , 4-b enzoquinone. m.p. 70 C-71 C. Elemental analysis for C25ll4006 Called. G, 68.77; , 9.23 Found C, 68.89; H, 9.30 Example 7 2,3-dimethoxy-5-methyl-l,4-benzoquinone (1.7 g) is dissolved in acetic acid (20 ml), and while the solution is stirred at 90 C, bis-19-metoxycarbonyltridecan- oyl peroxide (7.6 g) is added in small instalments. The temperature of the mixture is kept for 22 hours. After cooling te mixture is diluted with water and subjected to extraction with ether. The extract is washed with a saturated aqueous solution ol sodium chloride, an aqueous solution of sodium hydrogen carbonate and an aqueous solution of sodium chloride in the order mentioned, and dried. The solvent is distilled off and the residue is recrystallized from hexane. The above procedure gives 2,3-dimethoxy-6-(12-methoxycarbonyl - dodecyl)-5-methyl-l, 4-benzoquinone as orange-coloured needles. Melting point: 540C. Lithium aluminium hydride (740 mg) is suspended in dry ether (80 ml) and to tile suspension is added dropwise a solution of 2,3-dimethoxy-5-methyl-6-(12- methoxycarbonyl-dodecyl)-l,4-benzoquinonc (1.06 g) in dry ether (100 ml) under ice-cooling and stirring. After 1.5 ours, ice-water is added to te mixture to decompose excess lithium aluminium hydride. The mixture is acidified with hydrochloric acid and subjected to extraction with ether. The extract is washed with water and concentrated under a reduced pressure. The residue is dissolved in methanol (30 ml) and to the solution is added a solution of ferric chloride (12 g) in water (60 ml) and the mixture is stirred at roonl temperature for 1.5 hours. The reaction mixture is diluted with water and subjected to extraction with ethyl acetate. The extract is washed with water, and dried The solvent is distilled off under a reduced pressure. The residue is dissolved in chloroform and subjected to column chromatography on silica gel. The cim-stais obtained from the first-emerging fraction eluted with chloroformethanol (99:1) are recrystallized from ether-hexane The above procedure yields 6-(13-hydroxytridecyl)-2,3- dimethoxy-5-methyl-l,4-benzoquinone as yellow needles. (727 mg) Melting point 650C-660C. Example 8 Lithium aluminium hydride is added to a solution of methyl 22-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)- docosanoate (3 g) in tetrahydrofuran (30 Inl) and the mixture is stirred at room temperature for 1 hour. Under ice-cooling, a 10% aqueous solution of sulphuric acid is added to the reaction mixture. The mixture-is subjected to extraction with ether. The extract is washed with water and dried. The solvent is distilled off under reduced pressure, whereby 6-(22-hydrosar-(locosyl)-2?3- dimethoxy-5-methylphenol is obtained as colourless needles. m.p. 78 C-81 C. 22-(2-hydroxy-3,4-dimethoxy-6-methylphenyl)doco- san-1-ol(300 mg) and bis(4-hydroxysalicylidene)ethyl- enediiminocobalt (II) (50 mg) are suspended in dimethylformamide (200 ml). The mixture is stirred in an oxygen gas stream at atmospheric temperature and pressure for 7 days. The insolubles are filtered off and the filtrate is concentrated under reduced pressure. The residue is diluted with water and subjected to extraction with ethyl acetate. The extract is treated in a conventional manner and subjected to column chromatography on silica gel. Fractions eluted with cllloroform are collected and the solvent is distilled off under reduced pressure. Tile residue is subjected to recrystallization, whereby 6-(22-hydroxydocosyl)-2,3-dimethoxy-5-methyl-1,4- benzoquinone is obtained as orange-yellow needles. Melting point 89-90.5 0C. Example 9. Aluminium chloride (8.2 ) is added tl) a solution of 12-acetoxy-n-(dodecanoyl chloride (.5 ) in 1,2- dichioroeth.lllc (30 ml), and the mixture is stirred at room temperature for 2 hours. The mixture is cooled to 5 C and a solution of 3,4,5-trimethoxytoluene (5.6 g) in 1,2-dichloroethane (20 ml) is added to the above mixture. The whole mixture is stirred at room temperature for 72 hours, and at 50 C-60 C for 30 minutes. Methanol (200 ml) is added to the reaction mixture and the mixture is stirred at 50 C for 3 hours The solvent is distilled off, and the residue is subjected to extraction with dichloromethane. The dichloromethane layer is washed with water and dried over magnesium sulphate. The solvent is distilled off, thereby leaving crude crystals. The product is recrystallized from ether-hexane (1:1) to give 6-(12-hydroxy-1-oxododecyl)-2,3-dimethoxy-5-methyl- phenol (8.5 g) as colourless needles. Melting point 82 C. 5% palladium-carbon (50% hydrous) (1.1 g) and 70% perchloric acid (0.1 ml) are added to a solution of 6-(12-hydroxy-1-oxododecyl)-2,3-dimethoxy-5-methyl- phenol (6.4 g) in acetic acid (150 ml), and the mixture is subjected to catalytic reduction at atmospheric temperature and pressure. After the absorption of hydrogen has been completed, the catalyst is filtered off and the filtrate is concentrated under reduced pressure. The residue is extracted with dichloromethane and the dichloromethane layer is washed with a 5% aqueous solution of sodium hydrogen carbonate and dried over anhydrous magnesium sulphate. The solvent is distilled off to give 6-(12-acetoxydodecyl)-2,3-dimethoxy- 5-methylphenol, (6.8 g) as a colourless oil. IRv Neatcm1: max 3450(OH), 1730(OAc), 1610,1580(Ar) NMR 0D013: ppni 1.1-1.8[20H,m,-(CH2)10-], 2.02(3H,s,OAc), 2.23(3H,s,C5-CH3), 2.55(2H,t,J=7Hz, C1-H2), 3.79(3H,s,OCH3), 3.83(3H,s,OCH3), 4.02(2H,t,J=6Hz, CH2OAc), 5.78(1H,s,C1-OH), 6.23(1H,s,C4-H) MS m/e: 394(M+),352, 334, 181. Potassium nitrosodisulphonate (18 g), water (300 ml), methanol (50 ml) and monopotassium phosphate (0.5 g) are added to a solution of 6-(l2-acetoxydodcyi)-2,3- dimethoxy-5-methylphenoi (6.1 g) in dimethylformamide (300 ml), and the mixture is stirred at room temperature for 30 days. The reaction mixture is subjected to extraction with dichloromethane and the organic layer is washed with water and dried over magnesium sulphate. The solvent is distilled off, thereby leaving crude crystals. The product is recrystallized from hexane to give 6-(12-acetoxydodecyl)-2,3-dimethoxy-5- methyl-1,4-benzoquinone (4.8 g) as orange-yellow needles. Melting point: 47 C. Concentrated hydrochloric acid (0.1 ml) is added to a solution of 6-(12-acetoxydodeeyl)-2,3dimethoxy-5-methyl-1,4-benzoquinone (4.4 g) in methanol (200 ml), and the mixture is kept standing at room temperature for 12 hours. To the reaction mixture is added sodium hydrogen carbonate (0.2 g), and the solvent is distilled off. The residue is dissolved in dichloromethane and the insoluble materials are filtered off Dichloromethane is distilled off, thereby leaving crude crystals. Recrystallization from hexane-ether (3:1) gives 6-(12-hydroxydodecyl)-2,3-dimethoxy-5-methyl-1,4- benzoquinone (3.8g) as orange-yellow needles. Melting point: 630C. IR#KBr cm 1 3550(OH), 1650, 1640, max CDCl3 1610(l-benzoquinone) NMR# ppm :1.1-1.8[20H,m-(CH2)- 10-], 2.00(3H,s,C5-CH3), 2.43(2H,t,J=7Hz, C1-H2), 3.62(2H,t,J=6Hz, 0112011), 397(611,s,OC1I3 X 2). MS m/e: 366(M+), 368(M++2), 336, 338, 197, 196,195. Example 10. Potassium nitrosodisulphonate (30 g), water (1.5 1), methanol (300 ml) and monopotassium phosphate (1.3 g) are added to a solution of 6-(20-hydroxyeicosyl)2,3-dimethoxy-5-methylphenol (2.3 g) in mimethylformamide (1.5 1), and the mixture is stirred at room temperature for 45 days. The reaction mixture is extracted with dichloromethane and recrystallized from ether. The above procedure gives 6-(20-hydroxyeicosyl)-2,3-dimethoxy-5methyl-1,4-benzoquinone (1.3 g) as yellow needles. KBr Melting point: 85 C. IR# max cm1 . 3500011, 1,0, CDCl3 1640, 1610(1,4-benzoquinone) NMR# 1.1-1.8[36H,m,- ppm (CE2)18-] 2.00(3S,s,C5-CH3), 2.43(211, t J=711z, C1-H2), 3.62(2H,t,J=6Hz, -CH20H), 3.96(6H,s,OCH3 X 2). MS m/e: 3 478(M+), 480(M++2),448, 450, 197, 196, 195. Example 11 A solution of potassium persulphate (2.7 g) in water (20 ml) is added to a solution of 6-(20-hydro xyeicosyl)-2,3-dimethoxy-5-methylphenol (0.6 g) in tetrahydrofuran, and the mixture is stirred in a nitrogen stream at room teperature for 72 hours The reaction product is extracted with ether and ether is distilled off. To the residual 6-(20-hydroxyeicosyl)2,3-dimethoxy-5-methylhydroquinone is added acetic anhydride (1 ml) and the mixture is kept standing at room temperature for 3 hours. The reaction mixture is extracted and treated in a conventional manner. The crude product thus obtained is recrystallized from hexane, The above procedure yields 6-(20-acetoxyeicosyl)-2,3 dimethoxy-5-methylhydroquinone-l,4-diacetate (0.31 g) as colourless needles. Melting point: 670C. By a similar manner to the corresponding procedure of Example 9, the product obtained above is treated with methanolic concentrated hydrochloric acid and then treated with methanolic ferric chloride, whereby 6-(20hydroxyeicosyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone is obtained. m.p. 8500. Example 12 Potassium nitrosodisulphonate (24 g), water (400 ml), methanol (30 ml) and monopotassium phosphate (1.0 g) are added to a solution of 6(1l-acetoxyundecyl)-2,3-dimethoxy 5-methylphenol (8 g) in dimethylformamide (400 ml). The mixture is stirred at room temperature for 28 days. The reaction product is extracted with dicliloromathane and the dichloromethane layer is washed with water and dried over magnesium sulphate. The solvent is distilled off, thereby leaving crude crystals. The crude crystals are rocrystallized from hexane to yield 6.4 g of 6(ll,acetozyundecyl)-2,3- dimethoxy-5-methyl-l , 4-benzoquinone as orange-yellow needles m.p. 4100. Concentrated sulphuric acid (0.1 ml) is added to a solution of 6-(ll-acetoxyundecyl)-2,3-dimethoxy 5-methyl-l,4-benzoquinone (4.2 g) in methanol (200 ml), and the mixture is kept standing at room temperature for 12 hours. To the reaction mixture is added potassium hydrogen carbonate (0.2 g) and the solvent is distilled off. The resulting mixture is dissolved in dichloromethane and the insolubles are filtered off. Dichloromethane is distilled off to leave crude crystals. Recrystallization from hexane-ether (3:1) gives 6-(l1-hydroxyundecyl )-2, 3- dimethxy-5-methyl-l,4-benzoquinone (3.6 g) as orangeyellow needles. m.p.: 57 C. Example 13 Bis(salicylidene)ethylenediiminocobalt (II) (salcomine) (0.1 g) is added to a dimethylformamide solution (50 ml) of 6-(1O-hydroxydecyl)-2,3-dimethoxy-5-methylphenol (2.53 g), and the mixture is stirred in an oxygen stream at atmospheric temperature and pressure for 72 hours. The solvent is then distilled off and the product is extracted with ether. The ethereal layer is washed with water and dried over anhydrous sodium sulphate, and the solvent is distilled off. The above procedure yields 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl- l,4-benzoquinone (2.32 g) as orange-yellow needles melting at 5200. Example 14 Bis(3-methoxysalicylidene)ethylenediiminocobalt (II) (0.2 g) is added to EMI26.1 EMI26.2 formamide solution (100 m) of 6-(10-hdrosa-decyl)- ,3- dimethos-5-metllylphenol (4.1 g), and the mixture is stirred in an oxygen stream at atmospheric temperature and pressure fo-r 72 hours. After the reaction has been completed, the solvent is distilled off a the residue is extracted with ether. The ethereal layer is washed with water and dried, and the solvent is distilled oft in a conventional manner. The crude crystals thus obtained are recrystallized from ethyl acetate-hexane (1:3). The above procedure yields 6-(l0-hydroxydecyl)-2,3- dimethoxy-5-methyl-l, 4-benzoquinone (3.77 g) as orangeyellow needles melting at 52OC53 0C. Example 15 Bis-salicylidene)ethylenediiminocobalt(II) (0.05 g) is added to a dimethylformamide solution (30 ml) of 6-(10-acetoXydecyl)-2,3-dimethoxy-5-methylphenol (1.6 g), and the mixture is stirred in an oxygen stream at atmospheric temperature and pressure for 72 hours. After the reaction has been completed, the solvent is distilled off and the product is isolated in the same manner as described in Example 13. The crude crystals thus obtained are recrystallized from hexane. The above procedure yields 6-(10-acetogydecyl-2,3-dimethoxy-5-methyl-1,4-benzoquinone (1.32 g) as orange-yellow needles melting at 3300. Example 16 Bis-(salicylidene)ethylenediimino.obalt(iI) (0.06 g) is added to a dichloromethane solution (30 ml) of 6- (10-hydroxy-decyl )-2, 3-dimethoxy-5-methylphenol (1.4 g), and the mixture is stirred in an oxygen stream at 200C and atmospheric pressure for 72 hours. After the reaction has been completed, the reaction mixture is passed through a bed of a small quanity of silica gel (about 15 g) to remove the catalyst. The solvent is then distilled off and the residue is recrystallized from ether-hexane (1:4). The above procedure yields 6- (10-hydroxydecyl)-2,5-dimethoxy-5-methyl-l,4-benzoquinone (1.01 g)as orange-yellow needles melting at 51-52 C. Example 17 Bis-(3-methoxysalicylidene)ethylenediiminocobalt(II) (o.o6 g) and pyridine (10 mg) are added to a. dimethylformamide solution (30 mg) of 6-(10-hydro-xydecyl)-2,3-dimethoxy5-methylphenol (1.6 g), and the mixture is stirred in an air stream at atmospheric temperature and pressure for 72 hours. After the reaction has been completed, the reaction product is isolated in the same manner as described in Example 13. The crude crystals thus obtained are recrystallized from ether-hexane (1:3). The above procedure yields 6-(10-hydroxydecyl)-2,3- dimethoxy-5-methyl-l,4-benzoquinone (1.1 g) as orangeyellow needles melting at 51 C-53 C. Example 18. Pyridine (0.5 ml) and bis(salicylidene)ethyl enediiminocobalt(II) (32 mg) are added to a dichloromethane solution (30 ml) of 6-(9-hydroxynonyl)-2,3 dimethoxy-5-methylphenol (1.8 g). The mixture is stirred in an oxygen stream at atmospheric temperature and pressure. The reaction product is isolated as in Example 13 and recrystallized from hexane. The above procedure yields 6-(9-hydroxynonyl)-2,3-dimethoxy-5 methyl-l,4-benzoquinone (1.2 g) as orange-yellow needles melting at 45 0C. Example 19 Bis-(salicylidene)ethylenediiminocobalt (II) (15 mg) is added to a dimethylformamide solution (20 mg) of 6- (6-hydroxyhexyl )-2, 3-dimethoxy-5-methylphenol (i.s g), and the mixture is stirred in an oxygen stream at atmospheric temperature and pressure for 72 hours. The reaction product is isolated as in Example 13 and purified by silica gel column chromatography. The etherhexane (1:1) eluate yields 6-(6-hydroxyhexyi)-2,3- dimethoxy-5-methyl-1,4-benzoquinone (1.1 g) as an orange yellow oil. Infrared absorption spectrum pNaxtem 1 max 3400(0E), 1660, 1640, 1610(1,4-benzoquinolle) Mass spectrum, m/e: 282(M+), 284(M++2), 252, 197, 196, 195. Example 20 Pyridine (50 mg) "and bis(4-hydroxysalicylidene)- ethylenediiminocobalt(II) (36 mg) are added to a dimethylformamide solution (30 ml) of 6-(12-hydroxydodecyl)-2,3- dimethoxy-5-methylphenol (1.7 g), and the mixture is stirred in an oxygen stream at atmospheric temperature and pressure for 72 hours. The reaction product is isolated as in Example 13 and recrystallized fror. ether. The above procedure yields 6-(12-hydroxydocyl)- 2,3-dimethoxy-5-methyl-1,4-benzoquinone (1.37 g), m.p. 63 C. Example 21 To a dimethylformamide solution (20 ml) of 6 (12-acetoxydodecyl)-2,3-dimethoxy-5-methylphenol (1.1 g) is added bis(salicylidene)ethylenediiminocobalt (II) (40 mg) and the mixture is stirred in an oxygen stream at atmospheric pressure and temperature for 72 hours. The product is isolated as in Example 13 and recrystallized from ether-hexane (1:1). The above procedure yields 6-(12-acetoxydodecyl)-2,3-dimethoxy5-methyl-1,4-benzoquinone (0.84 g) as orange-yellow needles melting at 470C. Example 22 Bis(salicylidene)eehylenediiminocobalt(( (40 mg) is added to a dimethylformamide solution (50 ml) of 6-(20-hydroxyeicosyl-2, 3-dimethoxy-5- methylphenol (4.0 g), and the mixture is stirred in an oxygen stream at atmospheric temperature and pressure for 72 hours. The product is isolated as in Example 13 and recrystallized from ether. The above procedure yields 6-(20-hydroxyeicosyl)-2, 3-dimethoxy-5-niethyl-i, 4-benzo- quinone (3.28 g) as yellow needles melting at 850C. Example 23. Pyridine (0.3 ml) and bis-(salicylidene)ethylenediiminocobalt(II) (14 mg) are added to a methanol solution (30 ml) of 6-9-acetoxynonyl-2,3-dimethoxy-5methylphenol (1.1 g), followed by stirring in an oxygen stream at atmospheric temperature and pressure for 72 hours. The reaction product is isolated as in Example 13 and recrystallized from hexane. The above procedure yields 6-(9-acetoxynonyl)-2,3-dimethoxy-5-methyl-1,4-benzo- quinone as orange-yellow needles melting at 30 C. Example 24 Bis(salicylidene)ethylenediiminocobalt(II) (10 mg) and sodium cyanide (2 mg) are added to n dimethylformamide solutidn (10 ml) of 1-acetoxy-6-(10-acetoxdecyl)-2,3- dimethoxy-5-methylbenzene (179 mg), followed by stirring in an oxygen stream at atmospheric temperature and pressure for 96 hours. After the reaction has been completed, 10 to 30 mg of ferric chloride are added to make the sodium cyanide-iron complex and, thereafter, the desired compound is isolated in the same manner as in Example 13. Recrystallization of the product from hexane yields 6-(10-acetox=decyl)-2,3-dimethoxy- 5-methyl-l,4-benzoquinone (103 mgY as orange-yellow needles melting at 370C380C. Example 25 Bis(salicylidene)ethylenediiminocobalt (II) (14 mg) is added to a dimethylformamide solution (20 ml) of 6-(10 acetoxydecyl)-2,3-dimethoxy-5-methyl-1-tetrahydropyranyloxy- benzene (240 mg),followed by stirring in an oxygen stream at atmospheric temperature and pressure for 72 hours. The reaction product is isolated in the same manner as in Example 13 and recrystallized from hexane. The above procedure yields 6 (10-acetoxydeeyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (110 mg) as orange-yellow needles melting at 370C-380C. Example 26 Bis(salicylidene)ethylenediiminocobalt (II) (10 mg) is added to a dimethylformamide solution of ?0-(3,4-dimethoxy-2- hydroxy-6-methylphenyl)decanoic acid (100 mg), followed by stirring in an oxygen stream at atmospheric temperature and pressure for 72 hours. The desired compound is isolated in the same manner as in Example 13 and recrystallized from ether. The above procedure yields 6- (9-carboxynonyl ) -2, 3-dimethoxy-5- methyl-l,4-benzoquinone (78 mg) as orange-yellow needles melting at 59 C-60 C. Example 27 A dimethylfomamide solution of methyl 10-(3,4 dimethoxy-2-hydroxy-6-methylphenyl ) decanoat e (129 mg) is oxidized in the same manner as in Example 26. This procedure yields 2,3-dimethoxy-5-methyl-6-(9-methoxyearbonylnonyl)-1,4- -benzoquinone (91 mg) as orange-yellow needles melting at 370C- 380C. Example 28 10-(2-Hydroxy-3,4,6-trimethylphenyl)decanoic acid (270 mg) is oxidized in the samo manner as in Example 13. This procedure yields, 2,3,5-trimethyl 6-(9-carboxynonyl)-l,4-benzoquinone (200 mg) as an orange-yellow oil. IR spectrum Neat 1 max 1705(C004 1640, 16l0(quinone) Example 29 1-(2-Hydroxy-3,4,6-trimethylphenyl)-g-hexanediol (331 mg) is oxidized in the same manner as in Example 13 to obtain 2,3,5-trimethyl-6-(1,6-dihydroxyhexyl)- 1,4-benzoquinone (229 mg) as an orange-yellow oil. Neat IR spectrum V max cm-1 3400(0H), 1640, 1610(quinone) Example 30 To a dimethylformamide solution (30 ml) of 2,3-dimethoxy-5-methylphenol (3 g) is added bis (salicylidene)ethylenediiminocobalt (II) (35 mg) and the mixture is reacted and worked up in the same manner as in Example 13. The resultant crude crystals are recrystallized from hexane. The above procedure yields 2,3-dimethoxy-5-methyl-l,4-benzoquinone (2.13 g) as orange-yellow needles melting at 59 C-60 C, Example 31 Bis(salicylidene)ethylenediiminocobalt(II) (120 mg) is added to a dimethylformamide solution (35 ml) of 2,3,4-trimethoxy-6-methyl aniline (3.4 g), followed by stirring in an oxygen stream at atmospheric temperature and pressure for 72 hours. The reaction product is isolated in the same manner as in Example 13 and recrystallized from hexane. The above procedure yields 2,3-dimethoxy-5-methyl-1,4-benzoquinone (2.9 g) as orange-yellow needles welling at 59 C-60 C. Example 32 4-Methoxy-3-methyl-1-naphtllol (1.88 g) and potassium hydride (401mg) are added to dry toluene (40 ml), followed by refluxing in a nitrogen stream for an hour. After spontaneous cooling, geranyl bromide (1.95 g) is added and the mixture is stirred at room temperature for 24 hours. To the reaction mixture is added petroleum ether (100 ml) and the precipitated potassium bromide is filtered off and the solvent is distilled off at room temperature and under reduced pressure. The residue is dissolved in dimethylformamide (50 ml) followed by addition of bis(salicylidene)ethylenediiminocobalt(II) (100 mg). The mixture is stirred in an oxygen gas stream at atmospheric temperature and pressure for one hour, after which the product is extracted with ether. The ethereal layer is washed with water and dried over anhydrous soldium sulphate, followed by distillative removal of the solvent. The residue is fractionally purified by silica gel column chromatography (developing solvent: ether-petroleum ether=l:l9). The crude crystals thus obtained are recrystallized from acetonealcohol. The above procedure yields menaquinone-2 (1.45 g) as yellow needles melting at 5l-530C.

Claims: CLAIMS: 1. A compound of the formula: EMI33.1 wherein m is an integer of 10 to 21;R1 is lower alkyl having 1 to 4 carbon atoms; B is a -C112-or -CO-group; when B is -CIl2-, R2 is hydrogen, lower alkyl having 1 to 4 carbon atoms or lower acyl having 1 to 8 carbon atoms, and when B is -CO-, R2 is hydrogen or lower alkyl having 1 to 4 carbon atoms. 2. A compound as claimed in Claim 1, wherein B is a -Cl'2- group. 3. A compound as claimed in Claim 1, lfhezein B is a -CO- group. 4. A compound as claimed in Claim 1, wherein R2 is hydrogen. 5. A compound as claimed in Claim 1, wherein R2 is lower acyl having 1 to 8 carbon atoms. 6. A compound as claimed in Claim 1, wherein R1 is methyl. 7. A compound as claimed in Claim 1, wherein m is an integer of 10 to 17. 8. A method for producing a compound of tlle formula: EMI33.2 [wherein each R is lower alkyl having 1 to 4 carboii 3 atoms or lower alkoxy having 1 to 4 carbon atoms, or two R3's taken together represent -CII=CH-tII=CII-; is is O or aii integer of 1 to 20 and when n is 1 to 20, A is a -Cu2-, EMI33.3 or -CO- group and Z is CH2OH, acyloxymethyl having 2 to 11 carbon atoms, esterif- o unesterified carboxyl having 1 to 5 carbon atoms, lower alkoxymethyl having 2 to 5 carbon atoms, silyloxnethyl having 4 to 7 carbon atoms or acetalmethyl having 5 to 8 carbon atoms; ; when n is 0, -A4CH2)n-Z is Z (wherein Q is O or an integer of 1 to EMI34.1 Z is hydrogell], which comprises oxidizing a compound of the formula: EMI34.2 (wherein X1 or X2 is hydroxyl or amino, with the other being hydrogen or an esterified hydroxyl group having 1 to 8 carbon atoms or etherified hydroxyl group having 2 to 8 carbon atoms; the other symbols are as defined above) with oxygen or air in the presence of a transition metal complex compound. 9. A method as claimed in Claim 8, wherein the transition metal complex compound is a cobalt-complex compound of the formula: EMI34.3 [wherein D is a vinylene group of EMI34.4 (R, is lower alkyl or phenyl) or an orthophenylene group of EMI34.5 (R5 is H, hydroxy or lower alkoxy); E is H or lower alkyl; G is an ethylene group of EMI34.6 (R6 is 11 or lower alkyl) or an orthophenylene group of EMI34.7

Inventors: GIICHI, GOTO, ISUKE, IMADA, MASAZUMI, WATANABE, TETSUYA, OKUTANI
Applicants: TAKEDA CHEMICAL INDUSTRIES, LTD.
Application year: 1980
Main classification: C07C50
IPC codes: C07C50, C07C66, C07C46, C07C41, C07C59, C07C43, C07C45