CONTACT LENSES WITH POLYMER BOUND ASEPTICIZING AGENTS

Abstract: Contact lenses having asepticizing agents bound to the lens polymer and methods for preparation of the same.

Description: CONTACT LENSES WITH POLYMER BOUND ASEPTICIZING AGENTS Cross Reference to Related Applications This is a continuation-in-part of my application Serial No. 797,295, filed May 16, 1977, entitled SYMMETRIC HYDROGEL MATRIX FOR CONTACT LENSES, hich discloses aseptic contact lens polymers, and of my application Serial No. 920,670, filed June 30, 1978, entitled STYRENE COPOLYMERS FOR CONTACT LENSES which discloses lens polymers asepticized by copolymerization of hydroxy substituted benzene monomers. Background of the Invention It has long been known that the human eye harbors potentially pathogenic microorganisms. ' ' ' ' Soft contact lenses are particularly subject to — 7 attack. The need for careful handling of contact lenses generally, and regular sterilization of soft contact lenses has presented a long-standing problem 2—9 in the art. Serious and intensive efforts have been made to solve this problem. The most extensive effort has related to a lens identified as the ASEPTOPLAST (trademark) lens. 3—6 Germicidal agents, hexachlorophene and a commercial germicide, COROBEX CP-4 (trademark) consisting of 0.3% boric acid, 2.25% phenylmercuric borate, 0.11% 2-ethyl-hexanol, and 0.75% di-isobutyl phenoxyethoxy-ethyl dimethyl ammonium benzyl chloride, balance inactive, were blended into the monomer before polymerization of the lens polymer, thus effectively forming a polymer with the germicide in solid solution in the polymer matrix form the ASEPTOPLAST lenses. These lenses were studied extensively and establish the biostatic effect of germicidal agents dissolved in solid lens polymers. (.The term "biostatic" is a term of art 4 and is used here m the same sense as used by Wesley. ) The ASEPTOPLAST lens approach, although a significant 5 effort to solve a very serious and long-standing problem, is limited by the very serious risk that leaching of the asepticizing agents from the lens polymer will not only decrease the biostatic action of the lens but, more importantly, may irritate or 10 seriously damage the eye of the user. These long-standing and very difficult problems of prior art lenses generally, and of prior art soft lenses in particular, are overcome according to the present invention by providing a biostatic lens polymer -"-5 in which the asepticizing agent is permanently bound to the polymer. The lens material itself is resistant to microbiological action and tends to prevent or inhibit growth of pathogenic organisms in the user's eye. 20 The polymers which are suitable for preparation of contact lenses as modified according to this invention are known lens polymers, and the monomer and polymer systems and methods of handling these systems are prior art. Many examples of lens polymers and monomers used 25 for polymerization and copolymerization to produce lens polymers are described herein and in the references cited at the end of this specification, which are incorporated herein as fully as though set forth for disclosure of the monomers, polymers and copolymers 30 and processing methods disclosed therein. Disclosure of the Invention Asepticizing agents inherently containing or modified by. reaction to include a reactive group caoable of polymerization, e.g., groups referred 35 to here as a "polymerizable, vinyl" group, i.e., one which is polymerized with, lens monomers also including a polymerizable vinyl group to bond the aseptic agent to the backbone of the polymer. In an alternative embodiment, an asepticizing agent is bonded to the polymer by reaction of a reactive group on the asepticizing agent with a reactive group on the already polymerized polymer. in my copending application Serial No. 797,295, filed May 16, 1977, I disclosed the reaction of benzyl- trialkyl ammonium halide, e.g., benzyl trimethyl ammonium chloride, bound to a lens polymer backbone by copolymerizing p-vinyl-benzyl trimethyl ammonium chloride with both hard lens polymers and soft lens polymers, e.g., methyl methacrylate and ethylene glycol dimethacrylates and soft lenses, e.g., hydroxyethyl methacrylate and triethylene glycol dimethacrylate polymers, as well as many modifications of these basic polymer systems. Other polymer systems disclosed included methyl methacrylate-vinyl pyrrolidone-triethyleneglycol dimethacrylate polymers, alpha-methyl-styrene modified methyl methacrylate polymer lenses, methacrylic acid modified methyl methacrylate lenses and vinyl triphenyl silane lenses. The general applicability of the principal of copolymerizing a polymerizable vinyl group containing asepticizing agent with polymerizable vinyl grou ' containing lens polymers generally is, thus, disclosed in my aforesaid application Serial No. 797,295. Specific examples of asepticizing gents which can be applied within this broad inventive concept, namely hydroxyl substituted benzene compounds, e.g., phenols, resorcinols and catechols, are more specifically disclosed in my aforesaid co-pending application Serial No. 920,670, filed June 30, 1978. -OMPI Λ, WiPO -s Additional examples of the inventive concept as applied to a variety of polymers and a variety of asepticizing agents are disclosed herein. Broadly, the invention contemplates contact lens polymers generally, without respect to the particular polymer or copolymer matrix, to which asepticizing agents are chemically bonded, without respect to the nature of the particular asepticizing agent. A preferred form of the invention contemplates bonding polymerizable vinyl group containing asepticizing agents into the backbone of polymers and copolymers formed by polymerizing polymerizable vinyl group containing lens monomers. Another preferred form of the invention contemplates the bonding, through any pair of reactive groups, of an asepticizing group to an already formed polymer. Specific preferred examples and embodiments of the invention are set forth in detail in the following specification. Best Mode for Carrying Out the Invention The present invention contemplates alternative routes to forming lens polymers and lenses in which the asepticizing agent is bonded to the polymer. Depending upon the nature of the asepticizing agent and the polymer, one particular approach may, in different circumstances, be preferred. Bonding Through a Polymerizable Vinyl Group Monomers for polymerization or copolymerization of contact lens polymers by the polymerization of polymerizable vinyl groups are very well known and generally, are suitable for use in this invention. The principles of this invention are most valuably utilized in connection with hydrogel lenses. Hydrogels, and their application to lenses have been disclosed by Wichterle et al, along with many variations of this C PI ' class of materials, in a series of patents issuing over t ,h, e past. nearl-,y _t_wo d._,ecad.es.33, '38, r 42-43, '46-47, ' 50-51, '55-56, '61, '64 S„ui.t.a.bl . e .hyd-rogel, polymer systems include the polymerization products of polyethylene glycol methacrylate and polyethylene glycol dimethacrylates; triethylene glycol methacrylate, methyl methacrylate and triethylene glycol dimethacrylate; dimethyl a ino ethyl methacrylate and tπethanol amine dimethacrylate. 33 Also applicable are hydrogels formed by the polymerization of esters of acrylic and methacrylic acid with alcohols having hydrophiliσ groups which after polymerization impart hydrophilic properties to the polymer. Wichterle et al disclose a number of acrylic and methacrylic acids, alcohols and cross-linking agents suitable for use in 38 preparing hydrogels of this class.. Starting materials for producing these hydrogels include the esters of acrylic and methacrylic acid with alcohols having hydrophilic groups which after polymerization impart hydrophilic properties to the polymer obtained. A major portion of a onoester of acrylic or methacrylic acid with a bifunctional alcohol which has an esterifiable hydroxyl group and at least one additional hydrophilic functional group is co-polymerized with a small amount of a diester of these acids and of an alcohol which has at least two ester¬ ifiable hydroxyl groups until a shape retaining body is obtained. The polyfunctional alcohols forming one of the constituent elements of the aforementioned monoester, and preferably also the alcohol constituent of the diester may have additional hydrophilic groups in their molecule which make the esters water soluble even after two or more of the hydroxyl groups are esterified by the acrylic or methacrylic acid. Many derivatives of acrylic or methacrylic acid other than the esters mentioned are also suitable as monomers in the copolymerization reaction leading to these hydrogels. These include, but are not limited to the following monomers: Dimethylaminoethyl methacrylate, piperidinoethyl methacrylate, morpholinoethyl methacrylate, methacryl- lygl colic acid, methacrylic acid as such, the monomethacrylates of glycol, glycerol, and of other polyhydric alcohols, the monomethacrylates of dialkylene glycols and polyalkylene glycols. The corresponding acrylates may be substituted for the methacrylates. Similarly, the diesters mentioned above may be replaced by other cross-linking agents such as triethanolamine dimethacrylate, triethanolamine trimethacrylate, tartaric acid dimethacrylate, triethylene glycol dimethacrylate, the dimethacrylate of bis-hydroxy- ethylacetamide. This general class of polymers has been used to prepare substantially anhydrous sparingly cross-linked hydrophilic polymers capable of being swollen when placed in water which consists of a high percentage, e.g., 98% or more, of a monoester of acrylic or methacrylic acid and an alcohol having an esterifiable hydroxyl group and at least one additional hydroxyl group and less than 2% of a cross-linking agent of a diester of the alcohol.56 Hydrogel lens polymers having selected properties and advantages which are suitable for use in this invention have been developed by a number of workers. 48 Seiderman discloses one such formulation. These polymers result from polymerization of hydroxyalkyl acrylate and methacrylate esters in copolymeric composition with minor amounts of a longer chain alkyl acrylate or methacrylate ester comonomer and a cross-linking comonomer such as allyl diglycol carbonate, glycol diacrylates, glycol dimethacrylates, polyglycol diacrylates and dimethacrylates, allyl methacrylates, triallyl cyanurate, divinylbenzene, and trivinylcyclohexane. Examples of suitable hydroxyalkyl methacrylates are: 2-hydrox ethyl methacrylates, 2-hydroxypropyl methacrylate, and the like. Other hydroxyalkyl methacrylates can be used with varying degrees of satisfaction. Also, alkylamino alkyl methacrylates, such as 2-dimethylaminoethyl methacrylate, 2-butylaminoethyl methacrylate, dimethylaminopropyl methacrylamide, quaternary salts of the same and the like, can be used. Examples of suitable alkyl methacrylates are: methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate and the like. Examples of suitable longer chain alkyl metha¬ crylates are: lauryl methacrylate, or other alkyl methacrylates wherein the alkyl radical thereof contains from out 5 to about 20 carbon atoms in the alkyl chain, such as capryl, palmityl, stearyl, cyclohexyl methacrylates, and alkyl cyclohexyl, and cyclo-octyl and cyclo-dodecyl methacrylates. ■ Examples of suitable cross-linking agents are: olefin glycol dimethacrylates such as : ethylene glycol dimethacrylate, diethylene glycol dimethacrylates, triethylene glycol dimethacrylate, tetrae hylene glycol dimethacrylate, polyethylene glycol dimethacrylate, 1, 4-butylene glycol dimethacrylate and 1,3-butylene glycol dimethacrylate. Examples of suitable catalysts are: benzoyl peroxide, chlorobenzoyl peroxide, lauryl peroxide, tertiary butyl peroxycarbonate, isopropyl peroctoate, etc. Modified polyvinylpyrrolidone resins in which a mixture of polyvinyl pyrrolidone, vinyl pyrrolidone, a hydroxyalkyl methacrylate and a cross-linking agent are reacted 53 may also be reacted with polymerizable vinyl group containing asepticizing agents according to the principals of this invention. Polymerizable vinyl group containing aseptic agents may, according to this invention, be polymerically bonded into hydrogels modified by the inclusion of glycidyl methacrylate, glycidyl acrylate and glycidyl crotonate , hard plaasstic hydrogels including triethylene glycol dimethacrylate 65 soft hydrophilic lenses modified by the inclusion of trimethylolpropane trimethacrylate, hydrogel copolymers of dihydroxyl alkyl acrylates and methacrylates copolymerized with alkyl acrylates and methacrylates, soft contact lenses made of a copolymer derived from a monomer mixture of hydroxyethyl or hydroxypropyl acrylates and methacrylates with 4 to 13 carbon hydroxyalkyl acrylates and methacrylates, 75 soft lenses prepared from copolymers modified by the inclusion of polyalkylene 76 glycol acrylates and methacrylates, hydrophilic polymers from polymerization of diester-free glycol monoester of acrylic or methacrylic acid and polyalkylene oxide acrylate or methacrylate. 80 It is within this invention to polymerize aseptic agents which include a polymerizable vinyl group with styrene modified acrylate and methacrylate polymers as disclosed in my co-pending application Serial No. 920,670, with vinyl pyrrolidone modified hydroxy alkyl acrylate hydrogels, with alkyl ether acrylates and methacrylates with vinyl silane and with substituted alkyl and hydroxyalkyl acrylate and Cf _ Q methacrylate monomers, all as disclosed in my copending application Serial No. 979,295, with methyl methacrylate modified hydroxy ethyl methacrylate lenses as disclosed in my copending application Serial No. 930,665 with the known acrylic and methacrylic lens polymers and modifications of acrylic and methacrylic lens polymers. It is also within the contemplation of this invention to polymerically bond a polymerizable vinyl group containing aseptic agent into the backbone of vinyl lens polymers of all classes. As used here, vinyl lens polymers include any polymer or copolymer resulting from the polymerization of reactive vinyl groups. Vinyl compounds which may -be used, as either major or minor constituents, in lens polymers of the class with which this invention may be used include the following compounds which include a polymerizable vinyl group having the general structure: H H C=C-R 1 , and homalogous allyl and crotyl compounds , wherein R, is selected from a group consisting of: (1) -Cl; (2) -F; (3) -Br; (4) lower, 1-4 carbon, alkyl, halogen, a ine and hydroxy substituted lower alkyl; (5) lower, 1-4 carbon, alkoxy, halogen, amine and hydroxy sub¬ stituted alkoxy; (6) lower, 6-9 carbon, aralkyl and phenyl substituted aralkyl, i.e.. wherein s is -H or a single or double substituent, alike or different, on the phenyl ring, said substituent being selected from the group consisting of -Cl, -F, -OH, -NH- . -N0 2 , -S0 4 , -CH and -0CH 3 ; - &&.£ A (7) t wherein 2 and R_ are selected from the group consisting of -H, lower alkyl, 6-9 carbon aralkyl, -(/ ; (8) - (/ (9) -CN; (10) r wherein one or more of R. through R is selected from the group consisting of -OH, -Cl, -F, lower alkyl, lower alkoxy, -NO-, -SO A ' and , R 2 and R_ being as defined above; R- always being selected to permit polymerization or copolymerization of the vinyl group monomer, vinylidene monomers, H j C—C H I R 4 wherein R.. and R . are as defined with respect to R, above are also suitable candidate monomers for use in this invention. Acrylates, and methacrylates especially, are particularly interesting monomers for use in this invention. Such compounds are generally of the formula: wherein R g or R β , or both, are selected from the group consisting of -H; -CH ; and R_ is selected from the group consisting of (1) -OH; (2) 0-R o , wherein R„ is 1 to 8 8 18 carbon alkyl or aralkyl, aryl or -OH, -Cl, -F, -NH 2 , =N0 2 or -SO. substituted aralkyl or aryl; (3) , R 2 and R 3 being as defined above; (4) -NCO; or (5) -CN. Vinyl ethers, as a class, having a wide range of non-vinyl moiety components are highly suitable monomers for use in this invention. Included are such compounds as C=C-0-R g wherein R g is selected from a group consisting of aryl and 1-18 carbon alkyl and aralkyl, which may be substituted with one or more substituents selected from the group consisting of Q -OH, -Cl, -F, -NH 2 , wherein - and R, are as defined above , -NO„ and -SO . , 5 Acrylamides such as dimethylaminoethyl acrylamides, dimethylaminopropyl acrylamide and analogs of the above, are suitable for use in this invention. Suitable methacrylamides include dimethylaminopropyl methacrylamide, dimethylaminoethyl methacrylamide, and the diethylamino and methylethyla ino analogs of the above. Difunctional methacrylamides are also contemplated, e.g. , aminoethylaminoethyl dimethacrylamide, aminopropylaminoethyl di ethacrylamide, etc.. , and aminopropyIpiperazinepropyl dimethacrylamide. It is not necessary that the entire polymer be formed via polymerization of "vinyl" group, i.e., aliphatic carbon-carbon double bond; indeed, any polymer which is derived from any monomer or group of monomers or prepolymers in which some or all polymerization occurs via vinyl polymerization may be used within the content of this invention. For example, some silicone monomer systems include polymerizable vinyl group monomers, for example Such monomers may be a minor part of the total monomer system, but provide reactive sites for bonding polymerizable vinyl group containing asepticizing agents into the polymer to prevent any leaching of the asepticizing agent. Di-vinyl functional monomers of this class serve as cross-linking agents. OM Similarly, this invention is applicable to the POLYCON (Trademark) type lens in which both acrylate and silicone polymerization may occur. Asepticizing agents, generally, i.e., bactericides , fungicides, viricides, anti-rickettsiae agent, to which a polymerizable group is attached or can be attached directly or indirectly, may be used within the principle of this invention, irrespective of the particular nature of the asepticizing agent, so long as the asepticizing agent does not interfere with the polymerization process or destroy the optical properties of the lens polymer. These constraints are, of course, easily determined by simply empirical observation and experimentation. Polymeric drugs formed by polymerization 2 of vinyl groups have been the subject of investigation ' 13,14 —,15,16,18,30 and Λ pol -ymeri >ze Λ d qua * t.ernary ammonium surf . .ac 4 t.an 4 t.s and Λ chromophores13-14,'18,'21, '23-26, '32, '39, ' 73 '78—79' 81—82 are known. These materials, however, generally are water soluble liquids and, therefore, have no applicability in the context of the present invention, other than to illustrate the known principals of vinyl polymerization. 91 102 Fungicidal paints ' ,metal-silicon bond compounds 92 and biologically active polymers generally are known . While the present invention is not restricted to any particular class or classes of asepticizing agents, physiological compatability of the asepticizing agents with body tissue and fluids is, of course, a prerequisite. However, the constraint imposed by the necessity for physiological compatability is less severe in respect to the asepticizing agents in this invention than if the same asepticizing agents were contemplated for use in unpolymerized, unbound form. Generally, asepticizing agents bound as described in this invention will be less irritating and more compatible with body fluids and tissues than the unbonded asepticizing agents would be. The asepticizing agents should be effective within the general pH range of about 6.5 to about 8.5. Since differing asepticizing agents exhibit biocidal or biostatic (inhibiting growth of microorganisms) -effectiveness at differing concentration levels, only general guidelines for the amount of asepticizing agents which should be polymerized into the lens polymer can be given. For a given asepticizing agent, it is a simple matter to extrapolate from the biologically effective concentration of the asepticizing agent in its free form to the projected concentration of the bonded asepticizing agents which should be included in the polymer. Generally speaking, asepticizing agent concentration will range from about 0.001 to 10%, by weight, of the lens polymer and, most commonly, will fall within the 0.1 to 3% weight concentration range. Generally speaking, the same concentration of asepticizing agent which is effective as a biocide in solution will also be effective as a biostatic asepticizing agent in the same concentration in the lens. Since the asepticizing agents tend to be less irritating when bonded to the polymer, however, it is possible for the concentration of asepticizing agent in the polymer to be increased, e.g. , to from 3 to 10 times the optimally effective biocidal concentration of the asepticizing agent in the unbonded form in solution. Ultimately, the optimum biologically effective concentration of asepticizing agent in the polymer must be determined through established biological screening techniques, which are well established in clinical and developmental work. Exemplary of asepticizing agents having bacteriacidal and bacteriastatic effects which are suitable for use within the principals of this invention are chlorobutanol, hexachlorophene, chlorophenesin, benzylkonium compounds generally, sulfa derivatives, organo-mercurial compounds, hydroxyquinolin, substituted phenols generally, and analogs of these classes of compounds. Trichlorotertiary butyl alcohol exemplifies a class of compounds which are suitable for use in lenses according to the invention; indeed, -the present invention makes possible the use of this compound and analogs thereof as an asepticizing agent in connection with eye tissue notwithstanding that this class of compounds cannot be used alone without undue irritation to many users. Heretofore, for example, trichlorobutanol could not be used as an asepticizing agent for hydrogel soft contact lenses or as a preservative in hydrogel soft contact lens solutions because it concentrates in the hydrogel and leaches into the tear fluid irritating and damaging eye tissue. When used according to this invention, however, these compounds retain their physiological activity but are non-irritating or substantially less irritating to eye tissue than the compounds used alone. The following compounds are exemplary of this class of compounds as modified for use in accordance with this invention: CH=CH ! 2 HO-C-CH, ! 3 ccι 3 wherein n is a positive integer of from 1 to 10. It is desirable to space the biologically acrive moiety from the polymerizable vinyl group to minimize steric hindrance and interference with the polymerization process and also to enhance the activity of the biologically active portion of the molecule. Generally, spacer methyl, or other, groups of from 1 to 3 or 4 such groups are quite satisfactory, although spacer m.ethyl groups up to 10 carbon * atoms may conveniently be used. There is no reason why high molecular weight spacer moieties could not be used, within the limits of steric hindrance, but there is no apparent advantage in greater spacing. Chlorobutanol may also be reacted with glycidyl methacrylate to produce the following polymerizable vinyl group containing compounds which is suitable for use in this invention: Other reactive hydroxy containing aseptic agents with the same or other epoxy reactive group containing compounds which also include a polymerizable vinyl group to produce polymerizable aseptic agents according to this invention. Benzylkonium compounds, which may be both bacteriastatic and fungastatic asepticizing agents, may also be modified to include a polymerizable vinyl group for use in accordance with this invention. Hereto¬ fore, benzylkonium compounds could not be used in hydrogel soft lens because they concentrate in the hydrogel and leach into the eye and may cause severe tissue damage. This difficulty may be overcome by polymerizing the benzylkonium to the lens polymer to thereby bond the benzylkonium group to the polymer and prevent leaching with consequent irritation or damage to the eye. Exemplary of such benzylkonium compounds include: wherein R. and R- are alkyl groups having from 1 to 18 carbon atoms, and most commonly is methyl, and n is a positive integer of from 1 to 18. wherein R. and R 2 are alkyl groups having from 1 to 18 carbon atoms, and most commonly is methyl, and n is a positive integer of from 1 to 18. yy wherein R.. and R 2 are alkyl groups having from 1 to 18 carbon atoms, and most commonly is methyl, and n is a positive integer from 1 to 18. ' _ O wherein R, , R- and R^ are 1 to 18 carbon alkyl and, preferably, where two of R, , R 2 and R, are methyl and one of R, , R- and R, is a 8 to 18 carbon alkyl. wherein R-, , R~ and R- are 1 to 18 carbon alkyl and, preferably, where two of R, , R 2 and R, are methyl and one of R 1' R- and R, is a 8 to 18 carbon alkyl. O PI CH=CH. CCH- 1)n wherein n is a positive integer from 1 to 10 and R. , R 2 and R- are 1 to 18 carbon alkyl and, preferably, where two of R, , R- and R, are methyl and one of R. , R, _ and R- is a 8 to 18 carbon alkyl. ( wherein n is a positive integer from 1 to 10 and R. , R- and R, are 1 to 18 carbon alkyl and, preferably, where two of R, , R- and R, are methyl and one of R, , R 2 and R 3 is a 8 to 18 carbon alkyl. wherein n is a positive integer of from 1 to 2000 and R, , -R 2 and R_ are 1 to 18 carbon alkyl and, preferably, where two of R, , R 2 and R- are methyl and one of R, , R 2 and R- is a 8 to 18 carbon alkyl. CH=CH. where n is a positive integer of from 1 to 2000 and R- , 2 and R- are 1 to 18 carbon alkyl and, preferably, where two of R, , R 2 and 3 are methyl and one of R, , R 2 and R 3 is a 8 to 18 carbon alkyl. wherein n is a positive integer from 1 to 10 " and R.. , R 2 and R, are 1 to 18 carbon alkyl and, preferably, where two of R, , R 2 and R 3 are methyl and one of R, , R 2 and R 3 is a 8 to 18 carbon alkyl. Substituted phenols are suitable antibacterial asepticizing agents, exemplary of which are: wherein R. , R 2 , R_, R. and R- are halide, hydrogen, or 1 to 9 alkyl or alkoxy, at least one of R.. through R_ being halide, and R β is hydrogen or methyl. __0 wherein R.. , R 2 , R-, R. and R ς are halide, hydrogen, or 1 to 9 alkyl or alkoxy, at ' least one of R. through R g being halide, and R g is hydrogen or methyl. R 4 R 5 wherein R, , R 2 , R,, and R. and R 5 are halide, hydrogen, or 1 ^ to 9 alkyl or alkoxy, at least one of R, through R 5 being halide, and R is hydrogen or methyl. wherein R 1 , 2 , R,, R. and R-. are halide, hydrogen, or 1 to 9 alkyl or alkoxy, at least one of R. through R- being halide, and R g is hydrogen or methyl and n is zero or a positive integer of from 1 to 10. wherein R, , 2 , R,, R, and R-. are halide, hydrogen, or 1 : to 9 alkyl or alkoxy, at least one of R, through R 5 being halide, and R, is hydrogen or methyl and n is zero or a positive integer of from 1 to 10. wherein R.^, 2 , R 3 , R. and R_ are halide, hydrogen, or 1 to 9 alkyl or alkoxy, at least one of R, through R 5 being halide, and R β is hydrogen or methyl and n is zero or a positive integer of from 1 to 10. Chlorphenesin, OH CL / /r\ \> - -o0--iCH 2 CHCH 2 OH \ prepared by condensing equamolar amounts of p-chloro- phenol and glycidol, and its plural chloro-substituted analogs have antifungal properties which, by the methods of this invention, e.g. , the addition of the foregoing vinyl group containing derivatives, antigungal activity can be imparted to solid polymeric contact lenses. The microbiological activity of two classes of biocidal asepticizing agents can be imparted to contact lenses by polymerizing with the lens polymer asepticizing agents having different or plural biocidal characteristics. For example, the lens forming monomer can be copolymerized with polymerizable vinyl group containing quaternary ammonium compounds and vinyl group containing chlorphenesin compounds. These two classes of compounds are selected merely to exemplify the concept of including two asepticizi agents in a single lens forming polymer. Two biologically active agents can also be combined into one monomer containing a polymerizable vinyl group. As an example of this approach, a chlorphenesin-quaternary ammonium Aλ-- WI polymerizable vinyl group monomer can be prepared and copolymerized with the lens polymer. Merely exemplary of this approach to building non-leachable asepticizing agents into lens polymers are the following compounds which contain polymerizable vinyl group and the two classes of asepticizing agents referred to: wherein at least one of R, , R-, R, , R. and R ^ is a halogen and remainder is hydrogen, hydroxy, halogen, or lower 1 to 10 carbon alkyl. Hexachlorophene, a recognized bactericide, may be modified by the addition of the polymerizable vinyl group and included in polymers according to this invention. Examples of polymerizable analogs of hexachlorophene include: ; . wherein n is a positive integer from 1 to about 18, m is zero or a positive integer from 1 to about 18, R. through R- are halogen or lower, 1 to 10 carbon, alkyl or alkoxy, at least one of R. to R,, and at least one of Re to R- being halogen, the vinyl containing substituent in the next preceding two structures being attached to either phenyl ring at the ortho, meta or para positions with respect to the hydroxy groups, R- being hydrogen, halogen or 1 to 4 carbon alkyl. Biocidally effective halogen substituted phenyl compounds generally are satisfactory condidates for utilization in this invention. These classes of compounds would include the following: wherein at least one of R, through R g is halogen and each of R. through R 5 are halogen, hydroxy, hydrogen or lower 1 to 10 carbon, alkyl or alkoxy, and R β is hydrogen, haloge or 1 to 4 carbon alkyl, e.g. , pentachlorophenyl methacrylate, and analogous acrylates , crotonates and maleates ; * BΪ O wherein at least one of R, to R-. and of R,. to R. - is halogen and each of R, to R,_ is hydrogen, hydroxy, 5 halogen or lower, 1 to 10 carbon, alkyl or alkoxy; and vinyl / ~allyl, and crotonyl and glycidyl ethers, e.g., R 4 R 5 5 OMPI wherein at least one of R, to R^ is halogen, and each of R 1 to R 5 is hydrogen, hydroxy, halogen or lower 1 to 10 carbon alkyl or alkoxy. Other classes of biocidal asepticizing agents which can be used in accordance with this ' invention include: Quinolinol derivatives, to which a polymerizable group has been attached: wherein at least one of R, to R. is hydroxyl, and each of R- to R 4 is hydrogen, hydroxy, halogen or lower, 1 to 10 carbon, alkyl or alkoxy, and wherein one of 1 to R. is vinyl group containing substituent, at least one of R. to R, is hydroxyl and the remaining R, to . positions are hydrogen, hydroxy, halogen or 1 to 4 carbon alkyl. Organo-mercury compounds which have been modified clude a polymerizable vinyl group: R.-C=CH„ 1 l 2 CH 2 ) n R,-C=CH- 1 ! Δ C==0 I I 0 wherein R, is halogen, hydrogen or 1 to 4 carbon alkyl, and n is zero or a positive integer of 1 to 10, and polymerizable vinyl group containing thio-mercury compounds, e.g.. where X is a protonic acid group, or salt thereof, selected from the group consisting of: and Y is a polymerizable vinyl group containing substituent selected from the group consisting of n being zero or a positive integer of 1 to 10, and R, being hydrogen, halogen, or 1 to 4 carbon alkyl. Sulfa drugs generally, see THE MERCK INDEX, 9th Ed., pp. 1150-1159, to which a polymerizable vinyl group has been attached, for example: and nitrogen heterocyclic analogs thereof, wherein one ' of R, and R- is a polymerizable vinyl* group containing substituent selected from the group consisting of: R 3 being hydrogen, halogen or 1 to 4 carbon alkyl, and n being zero or a positive integer of 1 to 10. Polyvinyl amine-vinyl sulfonate sodium salt copolymers, as described by Dawson et al 13 may be converted to substituted sulfanila ides, and then graft polymerized with acrylic monomers as 90 described by Smets et al . By this means, a water- ~ soluble sulfanilamide containing polymer may be polymer bound into a hydrogel lens polymer to provide antibacterial properties. By the proper choice of substituents, an i-fungal, anti-viral, anti-rickettsial cind enzyme inhibitory properties may also be incorporated. The problem of fungus infusion into contact lenses may be eliminated by including a polymer bound anti-fungus type agent in the polymer network. CAPTAN© and its analogs may be used to produce a polymer network with a fungistatic agent bound to the polymer backbone. Examples of these asepticizing monomers include: / OMPI wherein R. is a polymerizable vinyl group containing substituent selected from the group consisting of: R- being hydrogen, halogen or 1 to 4 carbon alkyl, and n being zero or a positive integer of 1 to 10. Quaternary ammonium - polymerizable vinyl derivatives of CAPTAN® , e.g. : wherein n is zero or a positive integer of 1 to 10. ✓^$UR ' O Salicylanilide derivatives which include a polymerizable vinyl group, e.g.,: wherein R. or R 3 is a polymerizable vinyl group containing substituent selected from the group consisting of: R, R, - (CH- ) -C=CH, , -O- (CH- ) -C=s=CH„ Δ n Δ Δ n __ , Rr being hydrogen, halogen or 1 to 4 carbon alkyl, n being zero or a positive integer of 1 to 10, one of R- to R. is hydroxyl, the remainder of R-. to 4 being hydrogen, hydroxyl, halogen or 1 to 7 carbon alkyl or alkoxy. Adamantine derivatives such as adamantaryl methacrylate, adamantaneamine-glycidyl methacrylate adduct, adamantane carboxylic acid chloride, allyl adamantaneamine hydrochloride and methacryloxyethyl adamantane carboxylate add viricidal activity to lenses, Suitable enzyme inhibibors are the bioflavonoids quercetin and rutin modified with polymerizable vinyl groups in the form of alkenyl ethers or esters, and then copolyπerized with acrylic monomers to give a polymer bound enzyme inhibitor to prevent enzyme attack of hydrogel contact lenses; for example: "BJ KE ACT _ OMPI Antirickettisial effectiveness is built into lens polymers by copolymerization of analogous derivatives of chloroamphenicol. Lens blanks are prepared by mixing monomers and asepticizing agent conventionally and placing the mixture in an oven to begin the polymerization. Polymerization is carried out conventionally between 40°C and 100°C. Blanks are then annealed for several hours at 85°C, and lenses are cut and polished. In the case of soft lenses, the polished lenses are hydrated in saline solution to form hydrated hydrogel soft contact lenses. The following examples are for illustration only and are not to be construed as limiting the scope of the invention: Example 1 2-hydroxyethyl methacrylate 50.00 g CAPTAN ® (Chevron Chemical Co., recrystallized from 1,1,1-trichloroethane) 0.03 g The above were preheated together for 2 2/3 hours at a temperature of 116°C to dissolve the Captan in the 2-hydroxyethyl methacrylate. Methyl methacrylate 1.50 g Triethylene glycol dimethacrylate 0.50 g Methyl methacrylate and triethyleneglycol dimethacrylate were added and heating was continued for one hour at 89-93°C. Five drops of 2,5-dimethylhexane-2,5-diper- 2-ethyl hexoate CU.S.P. 245 U.S. Peroxygen Div. , Whitco Chem. Co.) was added and the mixture was blended and cured 4 1/2 hours at 90-106°C. The lens blanks were clear and of good optical quality. ' The hydration level was 34.5%. Example 2 2-hydroxyethyl methacrylate 100 . . 0 g Methyl methacrylate 3. . 0 g Trieth lenegl col dimethacrylate 1. . 0 g Benzalkonium chloride salt of dimethyl¬ aminopropyl methacryl mide 0 . .20 g 2,5-dimeth lhexane-2,5-diper-2-eth 1 hexoate 10 drops The above were blended thoroughly and cured at 85-95°C for two hours and 95-100°C for two hours. The lens blanks were clear and of good optical quality. Example 3 2-hydroxyethyl methacrylate 100.00 g Methyl methacrylate 3.0 g Trieth leneglycol dimethacrylate 1.0 g Benzalkonium chloride salt of dimethylaminoethyl methacrylate 0.20 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate 10 drops The above were blended thoroughly and cured at 85-95°C for two hours and at 95-100°C for two hours. The lens blanks were clear and of good optical quality. Example 4 2-hydroxyethyl methacrylate 100.0 g Methyl methacrylate 3.0 g Triethyleneglycol dimethacrylate 1.0 g Benzalkonium chloride salt of dimethylaminoethyl vinyl ether 0. 20 g _ U / 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate 10 drops The above were blended thoroughly and cured at 85-95°C for two hours and 90-100°C for two hours. The lens blanks were clear and of good optical quality. Example 5 2-hydroxyethyl methacrylate 100.0 g Methyl methacrylate 3.0 g Triethyleneglycol dimethacrylate 1.0 g Benzalkonium chloride salt of 1-dimethylamino dodecane and vinyl benzyl chloride 0.20 g 2-5-dimethylhexane-2,5-diper-2- ethyl hexoate 10 drops The above were blended thoroughly and cured at 85-95°C for two hours. The lens blanks were clear and of good optical quality. Example 6 2-hydroxyethyl methacrylate 00. , 0 g Methyl methacrylate 3 . , 0 g Triethyleneglycol dimethacrylate 1. , 0 g 5-hydroxy-5-trichloromethyl hexene-1 0 . . 20 g 2 ,5-dimethylhexane-2,5-diper-2-ethyl hexoate 10 drops The above were thoroughly blended and cured for two hours at 85-95°C and two hours at 95-100°C. The lens blanks were clear and of good optical quality, giving lenses of optical quality equal to the forumulation without the asepticizing agent. Example 7 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g 5 Triethyleneglycol dimethacrylate 0.54 g Pentachlorophenyl methacrylate 0.25 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate 5 drops The above mixture was blended until all of the 10. pentachlorophenyl methacrylate dissolved. The mixture was placed in polyethylene molds and cured at 96°C for 1 hour and 40 minutes, and annealed for 3 1/2 hours at 85°C. The lens blanks had a hardness of 85-86D on 1 top and 86-88D on the bottom. Two lenses were made, one had an equilibrium hydration level of 33.8% and the other 35.6%, the optics of both lenses were very good. Example 8 20 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g Pentachlorophenyl methacrylate 0.50 g N-Adamantanyl methacrylamide 0.50 g 25 2 ,5-dimeth lhexane-2,5-diper-2- ethyl hexoate 5 drops The above were thoroughly mixed, with care to dissolve all of the solid components. The mixture was placed in molds in the oven at 94°C, and cured 30 for 1 hour and 45 inues at 94°C and annealed for 4 hours at 88°C. 35 Example 9 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g Pentachlorophenyl methacrylate 0.10 g N-Adamantanyl methacrylamide 0.10 g 2,5-dimethylhexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div. , Whitco Chem. Co.) 5 drops The above were thoroughly mixed, with care to dissolve all of the solid components. The mixture was placed in molds in the oven at 95°C and cured for 1 hour and 45 minutes at 95°C and annealed for four hours and 15 minutes at 88°C. The lens blanks had a hardness of 83-88, and gave lenses with a hydration level of 32.4%. Example 10 2--hydroxyethyl methacrylate 100 . 00 g Methyl methacrylate 3 . 00 g Triethyleneglycol dimethacrylate 1 , 00 g Quercetin methacrylate 0 . 05 g 2,5-dimethylhexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 10 drops The above were thoroughly mixed with care to dissolve all of the solid component. The mixture was placed in molds in the oven at 95°C and cured for one hour and 30 minutes at 95°C and annealed for two hours at 85°C. The blanks had a hardness of 84-86D and gave lenses with a hydration level od 34.5% with a yellow cast. Example 11 2-hydroxyethyl methacrylate 100.00 g Methyl methacrylate 3.00 g Triethyleneglycol dimethacrylate 1.00 g Chloramphenicol methacrylate 0.10 g 2,5-dimethylhexane-2,5,-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 10 drops The above were thoroughly mixed with care to dissolve all of the solid component. The mixture . was placed in molds in the oven at 95°C and cured for one hour and 30 minutes at 95°C and annealed for two hours at 85°C. The blanks had a hardness of 84-86D and gave lenses with a hydration level of 34.0%. Example 12 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g 1-adamantaneamine-glycidyl methacrylate adduct 0.25 g 2-,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were mixed thoroughly with care to dissolve all of the adamantane derivative. The mixture was placed in molds in the oven at 95°C and cured for one hour and 53 minutes at 95-96°C and annealed for three hours and 30 minutes at 86°C. The blanks had a hardness of 76-87D and gave lenses with a hydration level of 35.9%. Example 13 2-hydroxyehtyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g 1-Adamantane carboxylic acid chloride 0.25 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 6 drops The above were mixed thoroughly, with care to dissolve all of the adamantane derivative. The mixture was placed in molds in the oven at 96°C and cured for one hour and 52 minutes at 96°C, and annealed for three hours and 30 minutes at 86°C. The blanks had a hardness from 80-87D and gave lenses with a hydration level of 31.4%. Example 14-- 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g N-1-Adamantanyl methacrylamide 0.25 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S. . 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were thoroughly mixed, with care, to dissolve all of the adamantane derivative. The mixture was placed in molds in the oven- at 95°C and was cured for one hour and 45 minutes at 94-95°C and annealed f or three hours and 30 minutes at 87°C. The blanks had a hardness- of 83-88D and gave lenses with a hydration level of 30.6%. Example 15 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g N-Allyl-1-Adamantaneamine Hydrochloride 0.25 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were thoroughly mixed with care to dissolve the solid component. The mixture was placed in molds in the oven at 95°C and cured for one hour at 95°C. The temperature was raised to 110°C over a period of 8 minutes and the cured continued at 110°C for one hour. The blanks were annealed at 85°C for eight hours. The blanks had a hardness from 77-85D and gave lenses with a hydration level of 33.5%. Example 16 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g Methacryloxyethyl adamantane- carboxylate 0.10 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S Peroxygen Div., Whitco Chem. Co.) 6 drops The above were thoroughly mixed, with care, to dissolve all of the adamantane derivative. The mixture was placed in molds in the oven at 95°C, and cured for one hour and 45 minutes at 95°C, and annealed for four hours and 15 minutes at 88°C. The lens blanks had a hardness of 84-88D and gave lenses with a hydration level of 35.5%. Example 17 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g Methacrylamidopropyl-dimethylbenzyl ammonium chloride 0.25 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were mixed thoroughly with care to dissolve all of the benzalkonium derivative. The mixture w-s placed in molds in the oven at 93°C and cured for one hour and 46 minutes at 93°C, and annealed for four hours at 86°C. The blanks had a hardness of 81-87D and gave lenses with a hydration level of 34.7%. Example 18 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g Methacrylamidopropyl-dimethylbenzyl ammonium chloride 0.25 g 2,5-dimethylhexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245., U.S Peroxygen Div., Whitco Chem. Co.) 5 drops The above were mixed thoroughly with care to dissolve all of the benzalkonium derivative. The mixture was placed in molds in the oven at 93°C and cured for one hour and 46 minutes at 93°C, and annealed for four hours at 86°C. The blanks had a hardness of 81-87D and gave lenses with a hydration level of 34.7%. Examnle 19 2-hydroxyethyl methacrylate 20.00 g Methyl methacrylate 0.60 g Triethyleneglycol dimethacrylate 0.20 g Allyl dimethyl benzalkonium chloride 0.20 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 2 drops The above were thoroughly mixed, with care to dissolve all of the benzalkonium derivative. The mixture was placed in molds in the oven at 94°C and cured for one hour and 45 minutes at 94°C and annealed for three hours and 30 minutes at 87°C. The blanks had a hardness of 87D and gave lenses with a hydration level of 27.0%. Example 20 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g Vinyl benzyl dimethyl dodeσyl ammonium chloride 0.25 g 2,5 dimethyl hexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were mixed thoroughly with care to dissolve all of the benzalkonium compound. The mixture was placed in molds in the oven at 95°C and cured one hour and 46 minutes at 95°C. The blanks wer annealed for eight hours at 85°C. The blanks had a hardness of 76-87D and gave lenses with a hydration level of 30.8%. Example 21 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g 5-hydroxy-5-trichloromethyl hexene-1 0.25 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were thoroughly mixed, with care to dissolve all of the hexene derivative. The mixture was placed in molds in the oven at 93°C and cured for one hour and 45 minutes at 93°C and annealed for four hours at 86°C. The blanks had a hardness of 82-87D and gave lenses with a hydration level of 34.7%. Example 22. 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g 2-methacryloxyethyl-2 ,22-trichloro- 5-butyl carbonate 0.25 g 2 ,5-dimethylhexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245, U.S Peroxygen Div., Whitco Chem. Co.) 5 drops The above were thoroughly mixed, with care to dissolve all of the carbonate derivative of chloro¬ butanol. The mixture was placed in molds in the oven at 96°C and cured for one hour and 45 minutes at 95-96°C, and annealed for three hours and 30 minutes at 85°C. The blanks had a hardness of 80-88D and gave lenses with a hydration level of 30.5%. Example 23 2-hydroxyethyl methacrylate 0 . 00 g Methyl methacrylate 3 . 00 g Triethyleneglycol dimethacrylate 1. 00 g N-vinylphenylsulfanilamide 0 . 05 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 10 drops The above were thoroughly mixed, with care, to dissolve all of the solid component. The mixture was placed in molds in the oven at 95°C and cured for one hour and 45 minutes at 95°C and annealed for four hours at 85°C. The blanks had a hardness of 85-86D and gave lenses with a hydration level of 33.8%. Example 24 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g N-4-vinylphenylsalicylamide 0.10 g 2,5-dimethylhexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were thoroughly mixed with care to dissolve all of the solid comoonent. The \Ni* * mixture was placed in molds in the oven at 95°C and cured for one hour and 45 minutes at 95°C and four hours at 85°C. The blanks had a hardness of 85-87D and gave lenses with a hydration level of 34.0%. Example 25 2-hydroxyethyl methacrylate 100.00 g Methyl methacrylate 3.00 g Triethyleneglycol dimethacrylate 1.00 g Vinylphenylmercury borate 0.10 g N-methacryloxyethyl ethylene-diamine triacetic acid di sodium salt 0.10 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 10 drops The above were mixed thoroughly with care to dissolve all of the solid components. The mixture was placed in molds in the oven at 95°C and cured for one hour and 30 minutes and annealed for two hours at 85°C. The blanks had a hardness of 85-87D and gave lenses with a hydration level of 34.6%. Example 26 2-hydroxyethyl methacrylate 100.00 g Methyl methacrylate 3.00 g Triethyleneglycol dimethacrylate 1.00 g Vinylphenylmercury borate 0.10 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 10 drops The above were thoroughly blended and then placed in molds in the oven at 95°C and cured for one hour and 30 minutes and annealed two hours at 85°C. The blanks had a hardness of 85-87D and gave lenses with a hydration level of 34.5%. Example 27 2-hydroxyethyl methacrylate 50.00 g Methyl methacrylate 1.50 g Triethyleneglycol dimethacrylate 0.50 g Pentachlorophenyl methacrylate 0.25 g 2,5-dimethylhexane-2 ,5-diper-2- ehtyl hexoate (U.S.P. 245, U.S Peroxygen Div., Whitco Chem. Co.) 5 drops The above were thoroughly mixed, with care to dissolve all of the pentachlorophenyl methacrylate. The mixture was placed in molds in the oven at 96°C and cured for one hour and 40 minutes at 96°C and annealed for three hours and 30 minutes at 85°C. The blanks had a hardness of 85-88D and gave lenses with a hydration level of 35.6%. Example 28 2-hydroxyethyl methacrylate 28.00 g Me-thoxyethyl methacrylate 20.10 g Methacrylic acid 4.09 g Triethyleneglycol dimethacrylate 0.50 g Pentachlorophenyl methacrylate 0.10 g N-adamantanyl methacrylamide 0.10 g 2,5-dimethylhexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245, U.S Peroxygen Div. Whitco Chem. Co.) 5 drops The above were thoroughly mixed, with care, to dissolve all of the solid components. The mix¬ ture was placed in molds in the oven at 94°C and cured for one hour and 49 minutes at 94°C, and annealed for four hours at 88°C. Example 29 2-hydroxye hyl methacrylate 50.00 g Triethyleneglycol dimethacrylate 0.64 g Pentachlorophenyl methacrylate 0.10 g N-adamantanyl methacrylamide 0.10 g 2,5-dimethylhexane-2 ,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div. Whitco Chem. Co.) 5 drops The above were thoroughly mixed, with care, to dissolve all of the solid components. The mix¬ ture was placed in molds in the oven at 94°C and cured for one hour and 48 minutes at 94°C, and annealed for four hours at 88°C. Example 30 2-hydroxyehtyl methacrylate 50.00 g Polyvinyl pyrrolidinone 2.50 g (Plasdone K-29-32) Pentachlorophenyl methacrylate 0.10 g N-adamantanyl methacrylamide 0.10 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops " The above were thoroughly mixed, with care, to dissolve all of the solid components. The mixture was placed in molds in the oven at 94°C and " cured for 1 hour and 48 minutes at 94°C, and annealed for four hours at 88°C. Example 31 2-hydrox ehtyl methacrylate 30.00 g Methoxyethyl methacrylate 10.00 g Glycidyl Methacrylate 10.00 g Pentachlorophenyl methacrylate 0.10 g N-adamantanyl methacrylamide 0.10 g 2,5-dimethyl hexane-2,5-diper-2- ethyl hexoate (U.S.P. 245, U.S. Peroxygen Div., Whitco Chem. Co.) 5 drops The above were thoroughly mixed and care was taken to dissolve the solid components. The mixture was placed in the oven at 88°C and cured at 88°C for 30 minutes and at 94°C for five hours. Example 32 2-hydroxyethyl methacrylate 50.00 g Styrene 2.40 g Vinyl pyrrolidinone 10.00 g Glycidyl methacrylate 1.80 g Diallyl Di-butyl tin 0.12 g 2,5-dimethylhexane-2,5-diper-2- ethyl hexoate 6 drops The above mixture was thoroughly mixed and then placed in molds in the oven. The mixture was cured at 83-86°C for one hour and 33 minutes and then annealed at 100°C for 1 hour, 100-125°C for 15 minutes, 125°C for 1 hour, 125-162°C for 30 minutes. The lens blanks were clear, had a dry hardness 84-86, lenses had a hydration level of 31.8%, and good optical quality. Example 33 2-hydroxyethyl methacrylate 40.00 g Methyl methacrylate 1.20 g Triethyleneglycol dimethacrylate 0.40 g 1-trichloromethyl-l-methyl- 0.10 g ethyl methacrylate (Chlorobutanol methacrylate) 2,5-dimethylhexane-2,5-diper-2- 1 drop ethyl hexoate Tertiary butyl perneodecanoate (Esperox 4 drops 33m, U.S. Peroxygen Div., Witco Chem. Co.) The above were blended thoroughly and cured at 65-66°C for 2 hours and 10 minutes and then at 100°C for 15 hours. The lens blanks were clear and of good optical quality with a hardness of 88-89D. Representation samples of the lens blank polymers which include polymerically bound asepticizing agents made in accordance with this invention, as described hereinbefore, were tested and found to exhibit biostatic activity. Thus, this facet of the invention contemplates virtually any lens polymer which is comprised of the . polymerization product of one or more monomers or prepolymers with one or more asepticizing agents wherein polymerization occurs by addition polymerization of ethylenically unsaturated carbon-carbon linkage, i.e., vinyl type polymerization of polymerizable vinyl groups on the lens monomer or prepolymer and on the asepticizing agent. Alternatives The principles of this invention are applicable to other lens polymer systems-generally. The two non-"vinyl" lens polymers (i.e., not formed by Silicone lenses are siloxane polymers, ( -si-o-) n R 2 wherein n is a large positive integer of from under 100 up to several thousand and R. or R-, or both, is typically methyl or phenyl but may often be lower alkyl and halogen substituted lower alkyIs. Known silicone monomers may be prepared in modified form to include a reactive group, e.g., -Cl, -OH, -NH 2 , on one of R or R 92.93,94,95,96,98,99,100, 101,102,103,106,108,109,UO^lll Aseptici2ing agents , of «.. classes described in detail hereinbefore for example, may be reacted, directly, or through an intermediate reactive group, to attach to the siloxane monomer and which become an integrally bound part of the final polymeric lens. The general reaction scheme is typified by the following, in which particular monomers and asepticizing agents are merely exemplary: X = Halogen ' -sulf amoylsulf onil-anilide which may be polymerized to, e.g. wherein m and n are positive integers of about 10 to several thousand. Virtually innumerable variations of this general reaction scheme using silicone monomers and asepticizing agents which include or which may be modified to include reactive groups may be adopted within the scope of this invention. Another specific example is an alcoholic functional group which can be attached to the agent and then used to bond to the monomer through a transesterification reaction. The alcoholic functional group may also, by an epoxy addition reaction, be bonded to a monomer possessing an epoxy group. These reactions are shown below: Transesterification - Agent Monomer CH- 0 I -3 II en., = c - c - OR Epoxy addition - RO - CH _-_-CIH-CH2-O-C CH, OH CH- RO - CH-CH 2 - O - C C I = 3 CH, CH„ OH Another example of a functional group would be an isocyanate group which could be reacted with a hydroxy substituted monomer to produce a polymerically bound urethane asepticizing agent. An example would be to react the agent, phenyl isocyanate with a HEMA monomer. With polymerization, the parachlorophenol isocyanate reacts with the HEMA to form a polymerically bound urethane bacteriacide within the polymer matrix of the contact lens. Another example of a functional group would be an aldehyde which could be reacted with a HEMA monomer to produce an acetal linkage. Another variation of the principle of this invention i s the reaction of an active group on an asepticizing agent directly or indirectly with an active group on cellulose acetate-butyrate. For example, paraσhloro- phenyl isocyanate can be reacted with a hydroxyl group on cellulose acetate-butyrate to bond an asepticizing agent to this lens material. This is, of course, but one example of a reactive couple and any other couple may be used. It is also possible to polymerize the agents possessing the polymerizable group first and then graft polymerize the monomer mixture onto the polymerized agent. Conversely, the monomer mixture may be polymerized to a low molecular weight prepolymer and then the agent possession a functional group may be polymerized to the prepolymer. From the foregoing principles and from the examples, which illustrate the invention and are not intended to be all-encompassing (indeed, many thousands of examples would be required to illustrate even all the major applica tions of the principles of this invention) , it will be seen that this invention contemplates contact lenses and contact lens polymers produced from any monomer wherein there is chemically bonded to the polymer, either through polymerization bonding as exemplified by vinyl group polymerization, or chemically bonded to a monomer, prepolymer or polymer (as opposed to solid solutions, etc. , for example) regardless of the specific polymers or asepticizing agents involved. Within this broad inventive concept there are many specific discoveries and inventions which are set forth in the preceding specification and which are recognized as inventions within the broad invention just described. References 1. 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Claims: I CLAIM AS MY INVENTION; 1. A contact lens comprising: (a) a lens polymer; (b) an asepticizing agent chemically bonded to said lens polymer such that the agent will not leach out of the lens polymer. 2. The contact lens of Claim 1 wherein the polymer is a hydrogel. 3. The contact lens of Claim 1 wherein the asepticizing agent is chemically bonded through carbon-carb double bond polymerization reaction with lens monomer or lens prepolymer. 4. A method of fabricating an aseptic contact lens polymer comprising: (a) mixing an asepticizing agent having a~"polymerizable group with a lens monomer or prepolyme system which is polymerizable with the polymerizable group on the asepticizing agent, and (b) co-polymerizing said asepticizing agent with said lens monomer to form a chemically bonded asepticized lens polymer. 5. A method of fabricating an aseptic contact lens polymer comprising: - (a) polymerizing asepticizing agent having a polymerizable functional group; and (b) polymerizing lens monomer onto said polymerizable asepticizing agent. 6. A method of fabricating an aseptic contact lens polymer comprising: (a) polymerizing a lens polymer or prepolymer - having polymerizable active groups on the lens polymer or prepolymer; and (b) condensation polymerizing a condensation polymerizable asepticizing agent onto the polymer or prepolymer to form a lens polymer or prepolymer 0 having chemically bonded thereto biologically active asepticizing groups. 7. A method of fabricating an aseptic contact lens polymer comprising: (a) polymerizing a lens polymer or prepolymer having addition polymerizable active groups on the lens polymer or prepolymer; and -< (b) addition polymerizing a polymerizable group containing asepticizing agent onto the polymer or prepolymer to form a lens polymer or 0 prepolymer having chemically bonded thereto biologically active asepticizing groups. 5 0 5

Inventors: FOLEY W
Applicants: FOLEY W
Application year: 1980
Main classification: C08F20
IPC codes: G02B1