NOVEL SUBSTITUTED NITRODIPHENYL ETHERS, HERBICIDAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THE PREPARATION THEREOF AND THE USE THEREOF FOR COMBATING WEEDS

Abstract: Novel compounds are provided which exhibit activity as herbicides for combating weeds. The novel compounds have the formula: wherein X is hydrogen, halo, trihalomethyl, alkyl, cyano or nitro; X¹ is hydrogen, halo or trihalomethyl; X² is trihalomethyl or halo; Y is O, NH, NR¹ or S; R¹ and R² are the same or different and are selected from hydrogen, (C₁-C₄) alkyl, phenyl and phenyl (C₁-C₄) alkyl; n is an integer of from 1 to 5; and Z is carboxy, amino, monoalkylamino, or dialkylamino. Also provided are agronomically acceptable salts, esters and amides of a compound of Formula I when Z is carboxy.

Description: Novel substituted nitrodiphenyl ethers, herbi-cidal compositions containing them, processes 'for the preparation thereof ahd the flse thereof for combating Weeds. This invention concerns the provision of new nitrodiphenyl ethers, the preparation thereof, herbicidal compositions containing them and methods of combating weeds. Diphenyl ethers are known to be effective weed control agents. See for example U.S. - Patent Nos. 3,928,416; 3,454,392; 3,798,276; 3,873,303; 4,001,005 and 4,029,493 among the many patents issued. However, herbicidal effectiveness of a diphenyl ether cannot be predicted from its structure only and often quite closely related compounds will have quite different weed control abilities. See, Advances in Agronomy, Vol. 24, pages 331, 332, 355, 356, 357 and 358, Herbicides, Chemical Degradation and Mode of Action, Kearney and Kaufman, Vol. 2, Dekker, Inc. pages 552-563 and 728-737 and Mode of Action of Herbicides, Ashton and Crafts and also U.S. Patent Nos. 3,454,392 and 3,776,961. An ideal herbicide should give selective weed control, over the full growing season, with a single administration at low rates of application. It should be able to control all common weeds by killing them as the seed, the germinating seed, the seedling, and the growing plant. At the same time, the herbicide shpuld be substantially non-phytotoxic to the crops to which it is applied and should decompose or otherwise be dissipated so as not poison the soil permanently. The known diphenyl ether herbicides fall short of these ideals and thus the search has continued to discover new herbicides which are more selective or which complement the activities of known diphenyl ethers. The new nitrodiphenyl ethers concerned in the invention are, in comparison with known herbicides, of utility in one or more of the following respects, viz. acceptable lack of phytotoxicity towards plants yielding an agronomic crop, broad spectrum weed control and acceptable toxicological properties. In accordance with the present invention, there is provided a new class of diphenyl ether herbicides having the following structural formula: EMI2.1 wherein X is hydrogen, halo, trihalomethyl (preferably trifluoromethyl), alkyl (e.g. (C1-C10)-, (C1-C6)- and, preferably, (C1-C4)alkyl), cyano or nitro; xl is hydrogen, halo or trihalomethyl (preferably trifluoromethyl); X2 is trihalomethyl (preferably trifluoromethyl) or halo; Y is O, NH, NR1 or S; R1 and R2 are the same or different and are selected from hydrogen, (C1-C4)alkyl, phenyl and phenyl (C1-C4)alkyl (preferably benzyl or phenetyl); n is an integer of from 1 to 5 (the groups -CR1R2- being the same or different when n= > l); ; and Z is carboxy, amino, mono- or di-alkylamino (preferably mono- or di-(C1-C4)alkylamino) and the agronomically acceptable salts, esters and amides of compounds wherein Z is carboxy. Examples of such salts include the alkali metal and alkaline earth metal salts, such as lithium, sodium, potassium, calcium, barium, strontium and magnesium. Examples of such esters include alkyl (preferably C1-C5, C6 or C7) optionally substituted with halo, particularly fluoro to form, for example, a CF3 group or moiety; alkoxyalkyl (preferably (C1-C4) alkoxy (C1-C6) alkyl) optionally subtituted with halo in the alkoxy moiety particularly fluoro to form, for example, a CF3 group or moiety; alkenyl (preferably C3-C5) such as allyl, a-methylallyl or a-ethylallyl); and alkynyl (preferably C3-C5 such as propynyl. Examples of amides are those in which the amido nitrogen atom contains one or two alkyl substituents, preferably (Cl-C4)alkyl such as methyl. One sub-class of compounds of Formula I are those in which X is hydrogen, halo, trifluoromethyl, (Cl-C4)alkyl, cyano or nitro, X preferably being chloro; xl is hydrogen, halo or trifluoromethyl, X1 preferably being hydrogen; X2 is trifluoromethyl or halo (preferably chloro); Y is O, NH or S (preferably O); R1 and R2 are the same or different and are selected from hydrogen, (C1-C4)alkyl and phenyl(C1-C4)alkyl; n is 1 to 5 (preferably 1 to 3 and more preferably 1 or 2); Z is as defined for Formula I (but is preferably -CO2(C1-C4)alkyl); and (when Z is carboxy) the agronomically acceptable salts, esters and amides. The term "halo" used in this specification means, unless otherwise defined, bromo, chloro, fluoro or iodo. The terms alkyl, alkoxy, alkenyl and alkynyl include all straight and branched chain groups (i.e. all isomeric forms) so that, for example, (C1-C4)alkyl means CH3, C2H5, C3H7, C C4H9 and all isomers of the last two groups. Another sub-class of compounds provided by this invention is represented by the formula: EMI4.1 wherein R1 and R2 are the same or different and are selected from hydrogen and (C1-C4)alkyl, n' is 1 or 2 and R is hydrogen, (Cl-C6)alkyl (optionally substituted with halo, (C1-C4)alkoxy or halo(C1-C4)alkoxy), (C3-C5)alkenyl, (C3-C5)alkynyl, an alkali metal cation or an alkaline earth metal cation. A preferred group of compounds of Formula IA are those wherein R1 and R2 are the same or different and are selected from hydrogen or (C1-C6)alkyl (preferably C1-C4); n' is an integer of 1 or 2 and R3 is hydrogen, an alkali metal, an alkaline earth metal, (C1-C4)alkyl optionally halo-substituted so as to contain a CF3 group, (C1-C4)alkoxy(C1-C4) alkyl or (C3-C5Xalkenyl. Examples of the compounds of the invention embraced by Formula I include: EXAMPLARY LIST 2-chloro-4-trifluoromethyl-3 '- (methoxycarbonylmethoxycarbonyl)-4'-nitrodiphenyl ether, 2,4,6-trichloro-3'-(methoxyearbonylmethoxycarbonyl)-4'- nitrodiphenyl ether, 2,4-dichloro-3'-(carboxymethoxyearbonyl)-4'-nitrodiphenyl ether, 2-chloro-4-trifluoromethyl-3 '- (sodiocarboxymethoxycarbonyl) -4' -nitrodiphenyl ether, 2-fluoro-4,6-dichloro-3'-{N(methoxyzarbonylmethyl)- carbamoyl)-4'-nitrodiphenyl ether, 2-fluoro-4-trifluoromethyl-3'-{(1-methoxycarbonyl)-n- propylthiocarbonyl)-4'-nitrodiphenyl ether, 2-fluorol-4-trifluoromethyl-6-chloro-3 '-f (1-allyloxy- <RTI ID=5.11> carbonyl)-n-butoxycarbonyl}-4'-nitrodiphenyl ether, 2,4,6-trichloro-3'-{(2-methoxy)ethoxycarbonylmethOxy- carbonyl)-4'-nitrodiphenyl ether, 2-bromo-4-trifluoromethyl-3'-{(2-ethoxycarbonyl)ethoxy- carbonyl)-4'-nitrodiphenyl ether, 2-methyl-4-trifluoromethyl-3'-{(1-methoxycarbonyl)phen- ehoxycarbonyl)-4'-nitrodiphenyl ether, 2-cyano-4-trifluoromethyl-3'-{-(methoxyearbonyl)-n- pentyloxycarbonyl}-4'-nitrodiphenyl ether, 2-nitro-4-chloro-3'-{2,2,2-trifluoroethoxycarbonylmethoxy carbonyl)-4'-nitrodiphenyl ether, 2-f luoro-4-bromo-3 '-f carbamoylmethoxycarbonyl}-4 '-nitro- diphenyl ether, 2,4,6-trichloro-3'-{(1-N,N-dimethylcarbamoyl)phenethOxy- carbonyl}-4'-nitrodiphenyl ether, 4-trifluoromethyl-3 '-f (1-methoxycarbonyl) benzyloxycarbonyl} -4'-nitrodiphenyl ether, 2,4-dichloro-3'-{: :(1-methoxycarbonyl)isopropoxyzarbonyl}- 4'-nitrodiphenyl ether, 2,4,6-trichloro-3'-{(1-methoxycarbonyl)isopropOxyCarbonyl} -4'-nitrodiphneyl ether, 2,4-dichloro-3'-{(lwmethoxycarbonyl)isobutoxyCarbonyl}- 4'-nitrodiphenyl ether, 2-f luoro-4, 6-dichloro-3 '-f (1-methoxycarbonyl) isopropoxy- carbonyl)-4'-nitrodiphenyl ether, 2, 4-dichloro-3' -f (1-methoxycarbony))-2-ph9nethoxycarbonyl} - 4 '-nitrodiphenyl ether, 2t4t6-trichloro-3t-{(2-methoxycarbonyl)isopropoxyzarbonyl} 4'-nitrodiphenyl ether, 2,4-dichloro-3'-{(1-methyl-3-methoxycarbonyl)-n-propOxy- carbonyl)-4'-nitrodiphenyl ether, 2,4,6-trichloro-3'-{(3-methoxycarbonyl)-n-propOxyCarbonyl}- 4'-nitrodiphenyl ether, and 2,4-dichloro-3'-{(4-methoxycarbonyl)-n-butoxyzarbonyl}-4'- nitrodiphenyl ether. The compounds of Formula I may be prepared by methods described in the literature for compounds of analogous structure or by methods specially devised for the purpose. It is, however, preferred to (1) react an acid halide with an alkoxy-substituted compound, (2) react an alkali metal or alkaline earth metal carboxylate with a halo substituted compound, (3) ,where necessary, react an appropriate intermediate with a nitrating agent or (4) react a metal phenate with an appropriately substituted 5-halo-2-nitrobenzene. Generically, the process for preparing a compound of Formula I may be defined as comprising: (A) reacting (1) a diphenyl ether of the formula: EMI7.1 with (2) a compound of the formula G(CRlR2)nZ where in the above two formulae X, X1, X2, R1 R2, n and Z are as defined in connection with Formula I, E is hydrogen or nitro, and D is -COC1, -COF or -COBr in which case G is HY (where Y-is as defined in connection with Formula I) or D is -(CO2)mM (whereM is an alkali metal or alkaline earth metal and m is 1 or 2) in which case G is C1, Br or F, followed (in the case where E in the starting diphenyl ether is hydrogen) by nitration to form the desired compound, or (B) reacting (1) a phenate, or the corresponding free phenol in conjunction with an alkali metal or alkaline earth metal base, said phenate being of the formula: EMI7.2 with (2) a compound of the formula Z(CR1R2) nCl(F or Br) where, in the above two formulae, X X1 x2 R1 R2 n and Z are as defined in connection with Formula I, M is the cation of an alkali metal or alkaline earth metal and m is 1 or 2. A first process embodiment comprises reacting a 4-substituted phenyl-3 '-halocarbonyl-4 '-nitrophenyl ether (Ir infra) with an appropriate compound in the presence of an inert solvent (e.g. toluene) and optionally in the presence of an acid acceptor. The reaction may be conducted at a temperature in the range of from about 200 to about 1500C and the reaction period may vary from about 15 minutes to about 24 hours; however, the reaction is generally conducted at 300 to 400C for a period of time of about 2 hours. The following reaction scheme illustrates this process: EMI8.1 wherein X xl, x2 Y, R1 Rê, n and Z are as defined in connection with Formula I. A second process embodiment comprises reacting a 4-substituted phenyl-3-alkali metal (or alkaline earth metal) oxycarbonyl-4'-nitrophenyl ether with a halo-substituted compound in the presence of an inert solvent such as dimethyl formamide, dimethyl sulfoxide, sulfolane or methylethyl ketone. This reaction can, for example, be carried out at a temperature in the range of from about 200 to about 150 C and the reaction period may vary from about 1/4 to about 6 hours. The following reaction scheme illustrates this process: EMI9.1 wherein X, X1, X2, R1, R2, n and Z are as defined in connection with Formula I and M is a cation derived from an alkali or alkaline earth metal. In place of a phenate of Formula III there may be used the corresponding free phenol in conjunction with an alkali metal or alkaline earth metal base. A thid process embodiment comprises reacting an appropriately substituted phenoxide with an appropriately substituted 5-halo-2-nitrobenzene. The following reaction scheme illustrates this process EMI9.2 wherein X, XÚ, Xê, Y, RÚ, Rê, n, Z and M are as defined for Formulae I and III. The reaction is generally conducted at a temperature in the range of from about 50 to about 150 0C and the reaction period may vary from about 1 to about 96 hours. Solvents which may be employed include dimethyl sulfoxide, dimethyl formamide, sulfolane, and methylethyl ketone. A fourth process embodiment comprises reacting a 4-substituted phenyl-3-alkali metal (or alkaline earth metal) oxycarbonyl phenyl ether with a halo substituted compound as described in the above second process embodiment, followed by nitration employing, for example, as the nitrating agent, nitric acid, nitric acid/sulfuric acid, nitroniumtetrafluoroborate, nitroniumhexafluorophosphate or acetyl nitrate. Solvents, if employed include sulfolane, acetic anhydride or acetyl nitrate. The temperature used may be in the range of from about 200 to about 2000C and is preferably in the range of from about 500 to about 150 0C. The reaction period may range from 1/2 to 6 hours. The following reaction scheme illustrates this process: EMI10.1 wherein X, X1, X2, R1, R2, n and Z are as defined in connection with Formulae I and III. The following examples are given by way of illustration. Percentages are on a weight basis unless otherwise noted. Analytical data for the most of the compounds prepared in accordance with the examples are given in Table II which follows the examples. Example 1 2-Chloro-4-trifluoromethyl-3w-(tert-butoxyearbonylmeth carbonyl) -4 '-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3-carboxy-4 '-nitrodiphenyl ether (46.2 g; 0.128 mole) was dissolved in dimethyl sulfoxide (100 ml). Potassium carbonate (17.7 g; 0.128 mole) was added and the reaction mixture was heated with stirring to 600C. The reaction mixture was then cooled to 15 0C and allowed to warm to room temperature. Tertbutyl bromoacetate was then added and the reaction mixture stirred at room temperature for one hour. The above reaction procedure was repeated and the products of the two reactions were combined and diluted with ether, the ether extract being washed with water, then with aqueous 1% sodium and finally with aqueous 5% sulfuric acid. The ether solution was then dried over anhydrous magnesium sulfate. The dried ether solution was filtered through activated silica gel and the ether evaporated to afford 104.8 g of 2-chloro-4-trifluoromethyl-3'-(tert-butoxymethoxycarbonyl)-4'-nitrodiphenyl ether which after recrystallization from hexane at 0 C had a m.p. of 250C. Elemental analysis: Found, C, 50.13; H, 3.51; N, 2.87; C1, 7.38; F, 12.30. C20H17ClF3NO7 requires C, 50.49; H, 3.60; N, 2.94; C1, 7.45; F, 11.98. Example 2 2-Chloro--4-trifliioromethyl--3' - (ca-rhoxymethoxycarbonyl) - 4-'-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3'--tert-butoxycarbonyl-methOxy- carbonyl-4'-nitrodiphenyl ether (12.0 g) was heated in an oil bath to 165 0C until bubbling ceased. The product was dissolved in ether, extracted into 5% aqueous potassium carbonate, the extract acidified with 5% aqueous sulfuric acid and then extracted with ether. The ether extract was dried over anhydrous magnesium sulfate, filtered through activated silica gel and the ether removed to afford 9.9 g of 2-chloro-4-trifluoromethyl-3'-(carboxymethoxyCarbonyl)- 4'-nitrodiphenyl ether. The product was recrystallized from toluene/hexane, m.p. 103.50 - 1060C. Found: C, 45.99; H, 2.59; N, 2.88; C1, 8.00; F, 13.02; C16H7ClF3NO7 requires C, 45.79; H, 2.16; N, 3,34; C1, 8.45; F, 13.58 Example 3 2, 4-Dichloro-3 ' - (t-butoxycarbonylmethoxycarbonyl) -4'- nitrodiphenyl ether A mixture of 2,4-dichloro-3'-carboxy-4'-nitrodiphenyl ether (20.7 g), potassium carbonate (9.7 g) and dimethyl sulfoxide (30 ml) was heated to 50 C for 10 minutes and then cooled to 30 C. Tert-butyl bromoacetate was then added, followed by the addition of 5 ml of dimethyl sulfoxide. The temperature of the reaction mixture rose to 350C and the mixture turned yellow. The reaction mixture was stirred for one hour and allowed to stand overnight at room temperature after which it was poured into water and extracted with 300 ml of diethyl ether. The ether solution was washed with water and then with aqueous 5% sulfuric acid and then with aqueous 5% sodium hydroxide. The ether solution was dried over anhydrous magnesium sulfate and filtered. Removal of the ether afforded 15 g of a yellowgreen oil which was dissolved in hot hexane and allowed to crystallize. Filtration afforded 10.5 g of 2,4-dichloro 31-(tert-butoxycarbonylmethoxycarbonyl) -4 '-nitrodiphenyl ether as yellow-white crystals, melting point 690 - 720C. EX-ampl'e 4 2,4-Dichloro-3'-(carboxymethoxycarbonyl)-4'-nitrodiphenyl ether 2t4-Dichloro-3l-(tert-butoxycarbonylmethoxycarbonyl)-4l- nitrodiphenyl ether (16 g) was heated at 1600 - 170 C for 90 minutes to afford by thermal decomposition a very viscous fluid orange-brown in colour. This viscous product was extracted with diethyl ether (200 ml) and washed with aqueous potassium carbonate solution. The aqueous phase was acidified with aqueous 5% sulfuric acid and extracted with ether. The ether solution was dried, filtered and the ether removed to afford 13.4 !g of crude product as a yellow oil. This material was dissolved in 200 ml of a mixture of carbon tetrachloride and hexane and allowed to cool. Filtration afforded 11.9 g of substantially pure 2,4-dichloro-3'-(carboxymethoxycarbonyl)4'-nitrodiphenyl ether, melting point 930 - 950C. Infrared spectral analysis and NMR analysis confirmed the structure. Example 5 2-Chloro-4-trifluoromethyl-3'-f (l-methoxycarbony3)ethoxy- carbonyl)-4'-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3'-carboxy-4'-nitrodiphenyl ether (10.0 g; 0.028 mole) was dissolved in methylethyl ketone (150 ml) and potassium carbonate (3.9 g; 0.028 mole) was added. The solution was heated with stirring to reflux and a white solid precipitated. The solution was cooled to room temperature and methyl a-bromopropionate (5.7 g) was added. The reaction mixture was heated to 750C for approximately 3 hours during which period additional methyl a-bromopropionate (1.0 g) was added. The reaction mixture was diluted with ether and the aqueous layers separated and discarded. The ether extract was washed with aqueous 5% sulfuric acid and then with aqueous 1% sodium hydroxide solution. The ether was dried over anhydrous magnesium sulfate, filtered through silica gel and the ether removed to afford 8.3 g of 2-chloro-4-trifluoromethyl-3-(1-carbo- methoxyethoxycarbonyl)-4'-nitrodiphenyl ether as an oil. Example 6 2-Chloro-4-trifluoromethyl-3'-{(1-ethoxyearbonyl')ethoxy- carbonyl}-4'-nitrodiphenyl ether To a solution of 2-chloro-4-trifluoromethyl-3'-chlorocarbonyl-4'-nitrophenyl ether (9.0 g; 0.0236 mole) in 1,2dimethoxyethane (25 ml) in a 50 ml round bottom flask was added, at room temperature,ethyllactate (2.8 g; 0.0236 mole) and pyridine (1.58 g; 0.0236 mole). The reaction mixture was stirred over the week-end at room temperature, and then heated to 75 0C for about 24 hours. The reaction mixture was filtered to remove solid and the filtrate concentrated to afford 12 g of a yellow oil. The yellow oil was chromatographed over 100 g of silica gel using toluene as the solvent to give 3.5 g of 2-chloro-4-trifluoromethyl-3' (1-carboethoxy)ethoxycarbonyl-4'-nitrodiphenyl ether as a yellow oil of 74% purity contaminated with a second product. Example 7 2-Chioro-4-trifluoromethylphenyl-3 ' -2f (N,N-dimethylamino) - ethoxycarbonyl}-4'-nitrophenyl ether Step A - Potassium 2-chloro-4-trifluoromethyl phenoxide 2-Chloro-4-trifluoromethylphenol (1.96 g; 0.010 mole) was dissolved in dimethyl sulfoxide (15 ml) and potassium carbonate (2.76 g; 0.020 mole) was added. The reaction mixture was stirred at room temperature overnight to afford potassium 2-chloro-4-trifluoromethylphenoxide. Step B - 2-Chloro-4-trifluoromethylphenyl-3'- 2{N,N-dimethylamino)ethoxycarbonyl}-4'-nitro phenyl ether To the product of Step A was added 5-fluoro-2 nitro- (N,N-dimethylaminoeth6xycarbonyl) benzene (2.93 g). The reaction mixture was stirred at room temperature for 3 hours and then warmed to 450C for about 18 hours. The reaction mixture was poured into carbon tetrachloride (100 ml) and extracted with two portions of water (2 x 50 ml). The carbon tetrachloride layer was dried over anhydrous sodium sulfate, filtered and the solvent removed under vacuum to afford 2.8 g of 2-chloro-4-trifluoromethyl phenyl-3'-2'4(N,N-dimethylamino)ethoxycarbonyl}-4'-nitro- phenyl ether. Recrystallization from benzene/hexane afforded substantially pure product having a melting point of 700-71.50C. Elemental analysis: Found C,48.94; H, 3.74; N, 6.18; C1, 8.14; F, 13.58; C18H16ClF3N2O5 requires C, 49.95; H, 3.73; N, 6.47; C1, 8.19; F, 13.14. The diphenyl ethers identified in Table I below are, following substantially the procedures of Examples 1 to 5, also prepared in accordance with the reaction scheme preceding the table. EMI15.1 TABLE I Ex. l 2 1 1 R2 n No. X XÚ Xê Y A AÚ RÚ Rê n Z 8 Cl H CF3 S Cl SH H H 1 CO2CH3 9 C1 H CF3 NH Cl NH2 H H 1 C 2CH3 10 C1 H CF3 O OK C1 H H 2 CO2H 11 C1 H CF3 O OK Br H H 3 CO2C2H5 12 Cl H CF3 O OK Br -CH C H H 1 CO2CH3 13 Cl H Cl O OK Br -CH2C6H5 H 1 C 2CH3 14 Cl H Cl O OK Br H H 1 CO2-t-C4Hg Example 15 2-Chloro-4-trifluoromethyl-3'-{(1-ethoxycarbonyl)isopro poxycarbonyl)-4'-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3'-carboxy-4'-nitrodiphenylether (9.04 g) and anhydrous potassium carbonate (6.91 g) in dimethyl sulfoxide (30 ml) were heated to 75 0C and ethyl a-bromoisobutyrate (4.9 g) in dimethyl sulfoxide (10 ml) was added and heating continued for 2 hours at 80-820C, at which point additional ethyl a-bromoisobutyrate (0.5 g) was added. After two additional hours of heating, the mixture was cooled and diluted with ether. The ether solution was washed with aqueous 5% H2SO4, then with aqueous 1% NaOH, dried over anhydrous magnesium sulfate, filtered through activated silica gel and finally thorough ly stripped at 0.5 mm/60-65 C, of unreacted bromoester. -The residue solidified to a yellow powder which was re crystallized from hexane to afford the desired ester, yield 1.8 g, m.p. 920-94.50C. Found: C, 50.15; H, 3.54; N, 2.89; C1, 7.54; F, 11.85. C20H17ClF3NO7 requires C, 50.45; H, 3.60; N, 2.94; C1, 7.45; F, 11.98. Example 16 2-Chloro-4-trifluoromethylphenyl-3 -f (2-methoxy) ethoxy- carbonylmethoxycarbonyl}-4' -nitrophenyl ether A suspension of 2-chloro-4-trifluoromethyl-3 '-carboxy- methoxycarbonyl-4'-nitrodiphenylether (7'.1 g) in thionyl chloride (2.5 g) was heated for 1 hour at' 1100C and then excess thionyl chloride was stripped off under reduced pressure. 2-Methoxyethanol (40 ml) was added and the mixture heated briefly to 95 C to form a solution. Excess 2-methoxyethanol was removed under reduced pressure and the residue taken up in ether and the solution washed with water and potassium carbonate solution, dried, filtered through activated silica gel, and stripped to yield the desired ester (7.5 g) as a yellow oil. Found: C, 48.40; H, 3.13; Cl, 8.01; F, 12.13; N, 3.62; C19H15ClF3NO8 requires C, 47.76; H, 3.16; Cl, 7.42; F, 11.93; N, 2.93. Example 17 2-Chloro-4-trifluoromethyl-3 '- (trifluoroethoxycarbonyl) - methoxycarbonyl-4'-nitrodiphenyl ether This compound was prepared from 2-chloro-4-trifluoromethyl3'-(carboxymethoxycarbonyl)-4'-nitrodiphenyl ether and trifluoroethanol (CF3CH2OH) following substantially the procedure of Example 16. Example 18 2-Chloro-4-trifluoromethyl-3'-methoxycarbonylmethOxY- carbonyl-4'-nitrodiphenyl ether The potassium salt of 2-chloro-4-trifluoromethyl-3carboxy-4'-nitrodiphenyl ether was prepared by dissolving the acid in methanol and adding an equivalent amount of potassium hydroxide in methanol and evaporating the methanol. The potassium salt was dissolved in dry dimethyl formamide and methyl -bromoacetate (14.3 g; 0.09375 mole) was added. The reaction mixture was heated to 1200C for 4 hours after which it was added to dilute hydrochloric acid and extracted with hexane. The hexane solution was washed until neutral and then filtered through activated silica gel. The solvent was removed to afford 16 g of 2-chloro-4-trifluoromethyl-3'-carbomethoxymethOxyearbonyl- 4'-nitrodiphenyl ether. m.p. 970-980C. Example l9 2-Ch-loro-4-trifluoromethylphenyl-3'-(allyloxyearbonyl- methoxycarbonyl)-4'-ni-trophenyl ether To a mixture of 2-chloro-4-trifluoromethylphenyl-3' carboxymethoxyearbonyl-4'-nitrophenyl ether (10.5 g) and potassium carbonate (4.1 g) in dimethylsulfoxide (30 ml) was added allyl bromide (3.0 g) at 25 C. The temperature was increased to 320C and a yellow mixture was formed. A sample tested on thin layer chromatography showed'a single spot. The yellow mixture was diluted with 300 ml of water and extracted with 2 x 200 ml portions of ether. The ether extract was washed with 100 ml of aqueous 5% potassium carbonate solution. The ether solution was dried over anhydrous magnesium sulfate, filtered through activated silica gel and the ether removed to afford 10.3 g of yellow oil which solidified. The solid was recrystallized from hexane to afford substantially pure 2-chloro-4 trifluoromethylphenyl-3'-(allyloxyearbonylmethOxyzarbonyl)- 4-nitrophenyl ether, m.p. 510-530C. Found: C, 49.94; H, 2.86; C1, 7.97; F, 12.49; N, 2.99; Cl19H13ClF3NO4 requires C, 49.63; H, 2.85; C1, 7.71; F, 12.40; N, 3.05. Example 20 2-Chloro-4-trifluoromethylphenyl-3'-f (N ,N-dimet'hyl) - carbamoylmethoxycarbonyl}-4'-nitrophenyl ether To a well stirred mixture of an aqueous solution of dimethylamine (40% aqueous; 20 ml) and diethyl ether (100 ml) there was added dropwise 2-chloro-4-trifluoromethylphenyl3'-chlorocarbonylmethoxycarbonyl-4'-nitrophenyl ether (4 g in 50 ml diethyl ether). The aqueous phase became clear yellow. The reaction mixture was stirred for 20 minutes, the aqueous phase discarded and the yellow ether solution was washed with aqueous 5% sulfuric acid and then with an aqueous 5% potassium carbonate solution. The ether solution was dried over anhydrous magnesium sulfate and filtered through activated silica gel. A precipitate formed which, after standing and cooling, was collected. The filtrate was stripped and the crystals which formed were collected and, combined with the first crop of crystals, resulted in 4.3 g of substantially pure 2-chloro-4 trifluoromethylphenyl-3-f (N,N-dimethyl) carbamoylmethoxy- carbonyl}-4-nitrophenyl ether, m.p. 108.50-1100C. Found: C, 48.43; H, 3.07; C1, 8.29; F, 13.27; N, 6.22. C18Hl4ClF3N206 requires C, 48.38; H, 3.16; C1, 7.94; F, 12.76; N, 6.27. p Example 21 2,4-Dichloro-3'-methoxyearbonylmethoxyearbonyl-4'-nitro- diphenyl ether A mixture of 2,4-dichloro-3-carboxy-4'-nitrodiphenyl ether (14.8 g), potassium carbonate (8.2 g) and dimethyl sulfoxide (30 ml) was warmed to 500C and then cooled to 33 C at which point methyl a-bromoacetate (7.7 g) was added dropwise. The reaction temperature increased to 450C and the reaction mixture was stirred for an additional hour and then ether and water were added. The ether solution was. washed with aqueous 5% sulfuric acid, then aqueous 5% sodium carbonate and finally aqueous 10% sodium hydroxide; it was then dried over anhydrous magnesium sulfate, filtered through activated silica gel and stripped to afford 14.5 g of a yellow green oil. The oil was dissolved in 300 ml of isopropanol at 35 0C. After cooling, drystals were collected and dried to afford 11.5 g of 2,4-dichloro 3 '-methoxycarbonylmethoxycarbonyl-4 '-nitrodiphenyl ether as yellow white needles m.p. 530-55.50C. Found: C,47.80; H, 2.64; C1, 18.10; N, 3.72; 0, 27.13; C16HllCl2NO7 requires C, 48.02; H, 2.77; C1, 17.72; N, 3.50; 0, 27.99. Ex'aflpie' '22 Sodium and potassium salts of 2-chloro-4-trifluoromethyl3'-(carboxymethoxycarbonyl)-4'-nitrodiphenyl ether (a) To a suspension of 2-chloro-4-trifluoromethyl-3' (carboxymethoxycarbonyl)-4'-nitrodiphenyl ether (2'. 1 g) in water (1,000 ml) there was slowly added dropwise over a 90 minute period an aqueous solution of sodium hydroxide (9.5 ml' of 0.5 N diluted to 50 ml). The reaction mixture was stirred for an additional 90 minutes and then filtered to remove undissolved starting materials. The water was removed under high vacuum at 300C-400C to afford 1.0 g of 2-chloro-4-trifluoromethyl-3'-(carboxymethoxyearbonyl)-4'nitrodiphenyl ether, sodium salt. (b) By following substantially the procedure describedin part (a) above and by substituting for the sodium hydroxide recited therein an equal molar quantity of aqueous potassium hydroxide there is obtained 1.2 g of the potassium salt of 2-chloro-4-trifluoromethyl-3' (carboxymethoxycarbonyl) -4' -nitrodiphenyl ether. Example 23 Lithium salt of 2-chloro-4-trifluoromethyl-3'-(carboxy- methoxycarbonyl)-4'-nitrodiphenyl ether To a solution of 2-chloro-4-trifluoromethyl-3'-(carboxy methoxycarbonyl)-4'-nitrodiphenyl ether (2.1 g; 0.005 mole) in diethyl ether (100 ml) under nitrogen was added n-butyl lithium solution in hexane (2.6 ml of a 1.9 M solution; 0.0049 mole). The solution turned dead red. After 30 minutes of stirring the solution darkened. The reaction mixture was stirred overnight at room temperature. The solvent was removed to afford 2.4 g of the lithium salt of 2-chloro-4-trifluoromethyl-3'-(carboxymethoxyCarbonyl)- 4'-nitrodiphenyl ether as a crystalline brown solid. Example 24 2,4-Dichloro-3'-{1-(methoxyearboty ethoxyearbonyL}-4'- nitro di-phenyl ether To a solution of 2,4-dichloro-3'-carboxy-4'-nitrodiphenyl ether (8.88 g; 0.03 mole) in dimethylsulfoxide (30 ml) was added potassium carbonate (8.29 g; 0.06 mole). The mixture was heated to 70 C for 5 minutes and then cooled to 20 C; there was then added methyl a-bromopropionate (5.01 g; 0.03 mole) in dimethyl sulfoxide (5 ml). After stirring the reaction mixture at room temperature for 90 minutes, it was diluted with ether (200 ml) and washed with water (100 ml). The ether phase was washed with aqueous 5% sulfuric acid and then 10 ml of aqueous 5% sodium hydroxide. The ether solution ogs dried over anhydrous magne- sium sulfate and then filteredeXthrough Bio-sil (silicic acid). Removal of the ether afforded 9.9 g of 2,4-di chloro-3'-{1-(methoxyzarbonyl)ethoxyzarbonyl}-4'-nitro- diphenyl ether as a yellow oil. Example 25 2-Chloro-4-trifluoromethyl-3'-{a-(methoxycarbonyl)-a- (benzyl)methoxycarbonyl)-4'-nitrodiphenyl ether To a stirred mixture of 2-chloro-4-trifluoromethyl-3'carboxy-4'-nitrodiphenyl ether (10.85 g; 0.03 mole) in methylethyl ketone (30 ml) was added potassium carbonate (8.3 g; 0.06 mole). An immediate reaction with gas evolution occurred leaving a paper-like mass. After warming for 15 minutes at 60 C the mixture was cooled and methyl a-bromo-a-benzyl acetate (7.3 g; 0.03 mole) was added. The emulsion was very thick and an additional 80 ml of methylethyl ketone was added. The reaction mixture was allowed to stand overnight and then stirring was continued. An additional 200 m of methylethyl ketone was added and the reaction mixture was heated to 60 C for 3 hours. The reaction mixture was cooled and diluted with diethyl ether (200 ml). The ether solution was washed with water (200 ml) and then with aqueous 5% sulfuric acid and, finally, with aqueous 5% potassium carbonate. The ether solution was dried over molecular sieves. The ether solution was filtered through activated silica gel and the ether removed to afford'8.3 g of a yellow oil. Thin layer of chromatography indicated a substantial amount of unreacted ester. The yellow oil was diluted with methylethyl ketone (70 ml) and an additional quantity of the nitrodiphenyl ether (7.2 g; 0.02 mole) and potassium carbonate (3.4 g- 0.02 mole) was added and the mixture heated to reflux and the refluxing was continued overnight. The product was extracted with ether and the ether solution was washed with water, then with aqueous 5% sulfuric acid and, finally, with aqueous 5% potassium carbonate solution. N The ether solution was dried over anhydrous magnesium sulfate, filtered through activiated silica gel and the ether removed to afford 1.9 g of 2-chloro-4-trifluromethyl 3'-{ -(methoxycarbonyl)-a-(benxyl)ethoxyzarbonyl}-4'- nitrodiphenyl ether. Example 26 2-Chloro-4-trifluoromethyl-3' -f a- (methoxycarbonyl) -a- (phenyl) metho-xycarbonyl'} 4 "-nitro-diphenyl ether To a mixture of 2-chloro-4-trifluoromethyl-3'-carboxy-4'nitrodiphenyl ether (7.23 g; 0.02 mole) in methylethyl ketone (25 ml) was added potassium carbonate (5.52 g; 0.04 mole). An immediate reaction occurred with gas evolution. An additional 100 ml of methylethyl ketone was added, followed by the addition of methyl a-bromophenyl acetate (4.58 g; 0.02 mole). The reaction mixture was stirred for 90 minutes and allowed to stand overnight at room temperature. Stirring was continued for an additional 4 hours at room temperature and then the reaction mixture was heated to 650C for 3 hours. The reaction mixture was cooled and diethyl ether (300 ml) was added. The ether solution was washed with water, then with aqueous 5% sulfuric acid and, finally, with aqueous 5% potassium carbonate solution. The ether phase was dried over molecular sieves, filtered through activated silica, gel and the ether removed to afford 8.5 g of 2-chloro-4-tri fluoromethyl-3'-{a-(methoxycarbonyl)-a-(phenyl)-methOxy- carbonyl}-4'-nitrodiphenyl ether as a yellow solid. Recrystallization from isopropanol afforded 5.0 g of fluffy white crystals, m.p. 11401170C. Example '27 2-Chloro-4-trifluromethyl-3'-{(ethoxycarbotyl)methylthio- carbonyl}-4' -nitrodiphenyl Cther 2-Chloro-4-trifluoromethyl-3 t -carboxy-4'-nitrodiphenyl ether (12.6 g; 0.03 mole) and thionyl chloride (4.2'g;- 2.25 moles) was stirred and heated in a bath at 1000C. The mixture melted and heating was continued at 1000C for an additional hour. An additional 2 g of thionyl chloride was added and the mixture heated for 30 additional minutes. The reaction mixture was allowed to stand overnight at room temperature and reheated for 2 hours. The excess thionyl chloride was removed under vacuum and chlorine using an oil bath at 100 C. The dark brown oil obtained was cooled and diluted with diethyl ether (50 ml). To this dark solution was added ethyl 2-mercaptoacetate (3.7 g). The reaction mixture was stirred for 2 hours at room temperature and then allowed to stand for 9 days (albeit fortuitously). The mixture was then diluted with diethyl ether and washed in water. The ether solution was washed with aqueous 5% sulfuric acid and then with aqueous 5% potassium carbonate. The ether solution was dried over anhydrous magnesium sulfate and then filtered through activated silica gel. Removal of the ether afforded 13.lg of product. This material was dissolved in diethyl ether (43 ml) and enough hexane (85 ml) was added until the solution became hazy. The hazy solution was passed through activated silica gel and the solvent removed to afford 9.1 g of 2-chloro-4-trifluoromethyl-3'-{ (ethoxycarbonyl) methylthiocarbonyl}-4'-nitrodiphenyl ether as a red oil. Example 28 2-Chloro-4-trifluoromethyl-3-[&alpha;(ethoxycarbonyl)propoxy- carbonyl]4'-nitrodiphenyl ether A mixture of 2-chloro-4-trifluoromethyl-3-carboxy-4 '- nitrodipehyl ether (10;9 g; 0.03 mole) and granular anhydrous potassium carbonate (8.3 g) in methylethyl ketone (50 ml) was heated for 1 hour at 600-700C and then cooled. Ethyl 2-bromobutyrate (5.9 g; 0.03 mole) was then added and the emulsion warmed to 50 C for 2 hours. The mixture was allowed to stand at room temperature overnight. Heating was resumed at 60070 0C for an additional 4 hours. Ether (100 ml) was added and the ether solution washed with water, followed by washing with aqueous 5% sulfuric acid and, finally, with aqueous 5% potassium carbonate. The ether solution was dried over magnesium sulfate and then filtered through activiated silica gel. The ether was removed to afford 6.2 g of 2-chloro-4-trifluoromethyl-3-f a (ethoxycarbonyl) propoxy- carbonyl}-4'-nitro-diphenyl ether. The material was dissolved in hexane (except for about 0.3 g of orange oil) and the hexane decanted and removed to afford 5.6 g of product. This material was redissolved in hexane and passed through 40 g of activated silica gel in hexane. Three cuts were taken and the last two combined and the hexane removed to afford 2.5 g of product as a yellow oil. Example 29 2-Chloro-4-trifluoromethyl-3-fN- (1-ethoxyca'rbonylethyl) - carbamoyl)-4'-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3'-carboxy-4'-nitrodiphenyl ether (0.04 mole) and thionyl chloride (5.4 g; 0.045 mole) were mixed together and refluxed for two hours. 100 ml of diethyl ether were added to the reaction mixture which was then addeddropwise to a mixture of ethyl L-analine hydrochloride (6.1 g; 0.04 mole) and 2,6-lutidine (8.51 g; 0.08 mole) dissolved in 25 ml of diethyl ether. The resultant red and black solution was then stirred at room temperature overnight. The black solution was diluted with diethyl ether and then washed with water. The ether solution was then washed in aqueous 5% sulfuric acid followed by washing with aqueous 5% potassium carbonate. The ether solution was dried over anhydrous magnesium sulfate and filtered through activated silica gel. Removal of the ether afforded a black oil which soon solidified. The solid was dissolved in hot hexane. The hexane was decanted and allowed to cool. The residual oil was extracted with hexane and the hexane extracts placed in a refrigerator. The first hexane extract afforded 0.06 g of product having a melting point of 450-470C. The second extract afforded a red black solid glass-like material, 3.9 g having a melting point of 4O0-490C. Example 30 2-Chloro-4-trifluoromethyl-3'-{±-(ethoxycarbonyl)isobutoxy- carbonyl)-4 '-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3'-carboxy-4'-nitrodiphenyl ether (14.5 g; 0.04 moles) was dissolved in dimethyl sulfoxide (40 ml). Potassium carbonate (11.0 g; 0.08 moles) was added to this mixture. The reaction mixture was then heated to 60 C. The reaction mixture was cooled to room temperature and ethyl 2-bromo-3-methylbutyrate (8.4 g; 0.04 moles) in dimethyl sulfoxide (10 ml) was then added. The reaction mixture was stirred at room temperature and allowed to stand and then extracted with diethyl ether, the ether solution being washed successively with water, aqueous 5% sulfuric acid solution and aqueous 5% potassium carbonate solution. The ether solution was dried over anhydrous magnesium sulfate and filtered through activated silica gel. Removal of the ether afforded 4.6 g of 2-chloro-4-trifluoro methyl-3'-{z-(ethoxycarbonyl)-isobutoxycarbonyl}-4'-nitro- diphenyl ether. Example 31 2-chloro-4-trifuloromethyl-3'-{1-(aminocarbonyl)ethOxy- carbonyl)-4'-nitrodiphenyl ether 2-chloro-4-trifluoromethyl-3'-carboxy-4'-nitrodiphenyl ether (30.0 g) was dissolved in dimethyl sulfoxide (30 ml) and heated to 800C. Potassium carbonate (12.6 g) was then added. Foaming occurred and, when the foaming ceased, the mixture was cooled in an ice bath to 38 0C. ot-Bromoprop- ionamide (13.9 g) was added and the reaction mixture was heated for 11/2 hours at 95 C. The reaction mixture was diluted with ether and the ether extract was washed successively with water, aqueous 1% sodium hydroxide and aqueous 5% sulfuric acid. The ether was removed and the residue crystallized from toluene. The toluene solution was filtered and crystals'formed which were not the desired amine. The filtrate was stripped to afford 4.0 g of desired 2-chloro-4-trifluoromethyl-3'-{1-(aminocarbonyl)- ethoxycarbonyl)-4'-nitrodiphenyl ether. Example 32 2-Chloro-4-trifluoromethyl-3'{1-(carboxy)ethoxycarbonYl}- 4'-nitrodiphenyl¯ ether The 2-chloro-4-trifluoromethyl-3'-{1-(methoxyzarbonyl)- ethoxycarbonyl)-4'-nitrodiphenyl ether of Example 5 (47.7 g; 0.107 moles) was mixed together with -toluene-sulfonic acid (1.0 g), dioxane (180 ml) and water (5 ml). The reaction mixture was heated, with stirring, to reflux for 6 hours. The reaction mixture was diluted with aqueous 5% sulfuric acid and then extracted with ether. The ether extract was itself extracted with aqueous 1% sodium hydroxide. This base extract was acidified with aqueous 5% sulfuric acid and extracted with ether. The first ether extract was dried over anhydrous magnesium sulfate, filtered through activated silica gel and the ether removed to afford 12.3 g of 2-chloro-4-trifluoromethyl-3'{1-(carboxy)- ethoxycarbonyl)-4'-nitrodiphenyl ether. Example 33 Sodium salt of 2-Chloro-4-trifluoromethyl-3'{1-(carboxy)- ethoxycarbonyl)-4'-nitrodiphenyl ether The acid of Example 32 (2.2 g) was dissolved in methanol (20 ml). To this solution was added sodium methoxide (0.27 g; 0.005 mole) dissolved in methanol (20 ml). The reaction mixture was stirred for 10 minutes and the methanol removed. The product was extracted with ether and the ether removed to afford 2.1 g of the sodium salt of 2chloro-4-trifluoromethyl-3'{1-(carboxy)ethoxyearbonyl}-4'nitrodiphenyl ether. Example 34 Potassium salt of 2-Chloro-4-trifluoromethyl-3' fl- (carboxy) ethoxycarbonyl}-4'-nitrodiphenyl ether The product of Example 32 (2.2 g) was dissolved in methanol. To this solution was added a solution of potassium hydroxide (0.28 g) in methanol (20 ml). The reaction mixture was stirred for 10 minutes and the methanol removed under vacuum. The product was extracted with ether and the ether removed to afford 2.1 g of 2-chloro-4-trifluoromethyl-3'(1- (carboxy) ethoxycarbonyl} -4 '-nitrodiphenyl ether, potassium salt, m.p. 100 -lQ5 C. Example 35 2-Chloro-4-trifluoromethyl-3'-{ss-(ethoxycarbonyl)-&alpha;-methyl- ethoxycarbonyl-4' -nitrodiphenyl ether A mixture of 2-chloro-4-trifluoromethyl-3' -chlorocarbonyl- 4'-nitrodiphenyl ether (10 g); ethyl 3-hydroxybutyrate (3.5 g) and lutidine (2.8 g) in toluene (15 ml) was heated with stirring to 55 C. Heating was continued (in the event fortuitously) for two days. The reaction mixture is diluted with water and extracted with ether. The ether solution was washed with a 5% sodium carbonate solution and then water. The ether solution was then dried over magnesium sulfate filtered through charcoal and activated silica gel and the solvent removed to yield 8.2 g of 2-chloro-4-tri fluoromethyl-3'-{ss-(ethoxycarbonyl) 4-methylethoxyzarbonyl}- 4'-nitrodiphenyl ether as an oil. Example 36 2-Chloro-4-trifluoromethyl-3'-(X-ethoxycarbonyl)-n-butoxy- carbonyl-4'-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3' -carboxy-4 '-nitrodiphenyl ether (10.85 g; 0.03 moles) was dissolved in methylethyl ketone (30 ml) and potassium carbonate (8.3 g; 0.06 moles) added; a solid formed. Additional methyl ethyl ketone (40 ml) was added and the emulsion heated in an oil bath at 100 C and then cooled in an ice bath. Ethyl 5-bromovalerate (6.27 g; 0.03 ml) was added and also additional methyl ethyl ketone(lO ml). The reaction mixture was heated to 600C for 5 minutes, cooled and stirred at room temperature for 2 hours at room temperature. The mixture was colored pink-purple. The emulsion was diluted with ether and the ether solution washed with water, then with aqueous 5% sulfuric acid and finally with aqueous 5% potassium carbonate. The ether solution was dried over anhydrous magnesium sulfate and filtered through activated silica gel. The ether was removed to afford 8.0 g of yellow oil. NMR showed impurity of ethyl 5-bromovalerate which was removed by distillation. The reside was 2.5 g of 2-chloro-4-trifluoro methyl-3'-(#-ethoxycarbonyl)-n-butoxycarbonyl)-4'-nitrodiphenyl ether. NMR and IR confirmed the identity of the product. Example 37 2-Chloro-4-trifluoromethyl-3' e±hoxycarbonvlmethoxycarbonyl- 4'-nitrodiphenyl ether 2-Chloro-4-trifluoromethyl-3'-carboxy-4'-nitrodiphenylether (193 g) was dissolved in methyl ethyl ketone (600 ml) and the mixture heated to reflux. Anhydrous potassium carbonate (81 g) was added portionwise with stirring over one hour. The temperature was then reduced to 72 0C and ethyl bromoacetate (100 g) was added and the reaction mixture heated at 60 - 70 C for about 20 hours. The reaction mixture was diluted with water and extracted with ether. The ether phase was washed with 5% aqueous potassium carbonate solution, and brine, dried over anhydrous sodium sulphate, filtered through activated silica gel and the solvent .removed to give 2-chloro-4-trifluoromethyl-3'ethoxycarbonylmethoxycarbonyl-4'-nitrodiphenylether m.p. 44 - - 520C. TABLE II DIPHENYL ETHERS- PHYSICAL DATA Example Molecular C found H found N found Cl found No. m.p. Formula (reqd) (reqd) (reqd) (reqd) 1 25 C C20H17Cl1F3N1O7 50.13 (50.49) 3.51(3.60) 2.87(2.94) 7.38(7.45) 2 103.5-106 C C20H17Cl1F3N1O7 45.99(45.79) 2.59(2.16) 2.88(3.34) 8.00(8.45) 3 69-79 C C19H17Cl2N1O7 51.87(51.60) 3.87(3.88) 3.65(3.17) 16.50(16.03) 4 93-95 C C15H9Cl2N1O7 46.52(46.65) 2.29(2.35) 3.78(3.63) 18.40(18.36) 5 - * C18H13Cl1F3N1O7 46.94(48.29) 2.90(2.93) 2.93(3.13) 8.20(7.68) 6 - * C19H15Cl1F3N1O7 49.16(49.39) 3.19(3.27) 3.31(3.03) 8.20(7.68) 7 70-71.5 C C18H16Cl1F3N2O5 48.94(49.95) 3.74(3.73) 6.18(6.47) 8.14(8.19) 11 - * C20H17Cl1F3N1O7 50.66(50.49) 3.80(3.60) 3.02(2.94) 8.27(7.45) 15 92-94.5 C C20H17Cl1F3N1O7 50.15(50.45) 3.54(3.60) 2.89(2.94) 7.54(7.45) 16 - * C19H15Cl1F3N1O8 48.40(47.76) 3.13(3.16) 3.62(2.93) 8.01(7.42) 17 - * C18H10Cl1F6N1O7 43.78(43.09) 2.02(2.01) 2.79(2.79) 7.04(7.07) 18 97-98 C C17H11Cl1F3N1O7 45.36(47.07) 2.76(2.56) 3.26(3.23) 9.26(8.17) 19 51-53 C C19H13Cl1F3N1O4 49.94(49.63) 2.86(2.85) 2.99(3.05) 7.97(7.71) * =oil TABLE II (continued) DIPHENYL ETHERS- PHYSICAL DATA Example Molecular C found H found N found Cl found No. m.p. Formula (reqd) (reqd) (reqd) (reqd) 20 108.5-110 C C18H14Cl1F3N2O6 48.43(48.38) 3.07(3.16) 6.22(6.27) 8.29(7.94) 21 53-55 C C16H11Cl2N1O7 47.80(48.02) 2.64(2.77) 3.72(3.50) 18.10(17.72) 22(a) - C16H8Cl1F3N1O7Na 41.72(43.51) 1.91(1.83) 2.82(3.17) 5.32(8.03) 22(b) - C16H8Cl1F3N1O2K1 45.15(41.98) 2.04(1.76) 3.19(3.06) 8.66(7.74) 23 - C16H8Cl1F3N1O7Li 45.65(45.15) 2.88(1.89) 2.80(3.29) 7.99(8.33) 24 - * C17H13Cl2N1O7 49.17(49.29) 3.09(3.16) 3.58(3.38) 17.74(17.12) 25 - * C24H17Cl1F3N1O7 55.29(55.02) 3.41(3.27) 2.83(2.75) 7.27(6.77) 26 114-117 C C23H15Cl1F3N1O7 54.28(54.18) 2.83(2.96) 2.94(2.75) 7.02(6.96) 27 - * C18H13Cl1F3N1O6S1 46.33(46.60) 2.72(2.82) 2.98(3.02) 8.43(7.44) 28 - * C20H17Cl1F3N1O7 52.28(50.48) 3.85(3.60) 3.01(2.94) 7.65(7.45) 29 45-47 C C19H16Cl1F3N2O6 49.08(49.52) 3.06(3.50) 5.24(6.08) 11.89(7.70) 30 - * C21H19Cl1F3N1O7 50.40(51.45) 3.82(3.91) 3.14(2.86) 9.16(7.24) 31 - * C17H12Cl1F3N2O6 51.67(47.18) 3.46(2.80) 5.58(6.47) 8.07(8.19) * = oil TABLE II (continued) DIPHENYL ETHERS- PHYSICAL DATA Example Molecular C found H found N found Cl found No. m.p. Formula (reqd) (reqd) (reqd) (reqd) 32 - * C17H11Cl1F3N1O7 47.23(47.08) 2.87(2.56) 2.88(3.23) 7.59(8.17) 33 105-110 C C17H11Cl1F3N1O2Na 44.27(44.81) 2.14 (2.21) 3.29(3.07) 7.42(7.78) 34 100-105 C C17H11Cl1F3N1O7K 43.88(43.28) 2.59(2.14) 2.88(3.23) 7.43(7.51) 35 - * C20H17Cl1F3N1O7 53.96(50.49) 3.99(3.60) 3.05(2.86) 7.23(7.45) 36 - * C21H19Cl1F3N1O7 53.46(51.49) 4.16(3.91) 2.71(2.86) 7.38(7.24) 37 44-52 C C18H13Cl1F3N1O7 48.28(48.08) 2.94(2.90) 3.01(3.10) 8.07(7.90) * = oil Table IIA which follws geves NMR data for oils in Table II. TABLE IIA N.M.R. Data-OILS Example No. 5 ÚH n.m.r. #(CDCl3) 8.1-6.9(m, 6H), 5.4(quart, 1H), 3.8(s,3H), 1.6(d, 3H). 6 ÚH n.m.r. #(CDCl3) 8.2-6.7(m, 6H), 5.4(quart, 1H), 4.2(s,2H), 1.6 (d, 3H), 1.3(t, 3H). 11 ÚH n.m.r. #(CDCl3) 8.1-7.1(m, 6H), 4.3(t, 2H), 4.0(quart, 2H), 2.6-1.8 (m, 4H), 1.1(t, 3H). 16 ÚH n.m.r. #(CDCl3) 8.2-7.0(m, 6H), 4.9(s, 2H), 4.5-4.3(m, 2H), 3.7-3.5 (m, 2H), 3.4(s, 3H). 17 ÚH n.m.r. #(CDCl3) 8.1-6.9(m, 6H), 4.9(s, 2H), 4.5(quart., 2H). 24 ÚH n.m.r. #(CDCl3) 8.0-6.8(m, 6H), 5.3(quart, 1H), 3.7(s,3H), 1.5(d, 3H). 25 ÚH n.m.r. #(CDCl3) 8.1-6.9(m, 11H), 5.5(t, 1H), 3.7(d, 2H), 3.6(s, 3H). 27 ÚH n.m.r. #(CDCl3) 8.3-7.0(m, 6H), 4.2(quart, 2H), 3.9(s,2H), 1.2(t, 3H). 28 ÚH n.m.r. #(CDCl3) 8.2-7.0(m, 6H), 5.2(t, 1H), 4.2(quart, 2H), 2.3-1.7 (m, 2H), 1.4-.8 (m, 6H). 30 ÚH n.m.r. #(CDCl3) 8.0-6.9(m, 6H), 5.0(d, 1H), 4.2(quart, 2H), 2.6-1.9 (m, 1H), 1.4-.9(m, 9H). TABLE IIA (continued) N.M.R. Data-OILS Example No. 31 ÚH n.m.r. #(CDCl3) 8.2-7.0(m, 6H), 6.4(s, 2H), 5.5(quart, 1H), 1.6(d, 3H). 32 ÚH n.m.r. #(CDCl3) 10.3(s, 1H), 8.1-6.9(m, 6H), 5.4(quart., 1H), 1.6(d, 3H). 35 ÚH n.m.r. #(CDCl3) 8.0-6.8(m, 6H), 5.5(quart, 1H), 4.1(quart., 2H), 2.6 (2d, 2H), 1.3(t, 3H), 1.2(t, 3H). 36 ÚH n.m.r. #(CDCl3) 8.1-6.9(m, 6H), 4.5-4.2(m, 2H), 4.2(quart., 2H), 2.6 2.2(m, 2H), 2.0-1.6(m, 2H), 1.2(t, 3H). It will be evident that compounds of Formula I may be used in the preparation of other compounds of Formula I. For example, it will be seen from some of the foregoing examples that there may be used for this purpose compounds of Formula I wherein Y is oxygen and Z is carboxy, a carboxy ester, a carboxy salt or a carboxy amide (hereinafter for brevity referred to as "precursor compounds"). An example (vide Example 16) of the use of such a precursor compound is the conversion of a free carboxylic acid (i.e. Z = COOH) to an acid chloride, fluoride or bromide, eg by reaction with a halogenating agent such as thionyl halide N in a suitable liquid medium. The acid halide can then be reacted with ammonia or an amine (eg mono- or di-(C1-C4)- alkyl amines) to give an amide. Alternatively (vide Examples 16 and 17), the acid halides may be reacted with an appropriate hydroxy compound, if necessary in the presence of a hydrogen halide acceptor, to give an ester. Examples of hydroxy compounds are alkanols optionally substituted with halo, alkoxy and/or haloalkoxy. The precursor compounds of Formula I wherein Z is carboxy may be converted to salts, eg by reaction in solution or suspension with a strong base such as an alkali metal hydroxide (cf. Examples 22 and 23) or an alkaline earth metal hydroxide. The salts can then be reacted with an appropriate chloro, bromo or fluoro compound to give an ester, an example of this reaction being given in Example 19. When the precursor compounds are esters of compounds of Formula I wherein Z is COOH, the esters may be'converted by hydrolysis to the free acids as in Example 32. In some cases the esters may converted to the free acids simply by thermal decomposition as in Examples 2 and 4 where the tbutyl esters are thermally decomposed by the loss of isobutylene. The following is a listing of some of the preferred compounds of Formula I. TABLE III EMI36.1 Example X X1 X2 Y R1 R2 n Z 1 Cl H CF3 O H H 1 CO2-t-C4H9 2 Cl H CF3 O H H 1 CO2H 3 #Cl H Cl O H H 1 CO2-t-C4H9 4 Cl H Cl O H H 1 CO2H 5 Cl H CF3 O CH3 H 1 C 2CH3 6 Cl H CF3 O CH3 H 1 CO2C2H5 11 Cl H CF3 O H H 3 CO2C2H5 15 Cl H CF3 O CH3 CH3 1 CO2C2H5 16 Cl H CF3 O H H 1 CO2CH2CH2OCH3 17 Cl H CF3 O H H 1 CO2CH2CF3 18 Cl H CF3 O H H 1 CO2CH3 19 Cl H CF3 O H H 1 C 2CH2CH=CH2 20 Cl H CF3 O H H 3 CON(CH3)2 21 Cl H Cl O H H 1 CO2CH35 22 Cl H CF3 O H H 1 CO2Na TABLE III (continued) Example X XÚ Xê Y RÚ Rê n Z 22a Cl H CF3 O H H 1 CO2K 23 Cl H CF3 O H H 1 CO2Li 24 Cl H Cl O CH3 H 1 CO2CH3 25 Cl H CF3 O CH2C6H5 H 1 CO2CH3 26 Cl H CF3 O C6H5 H 1 CO2CH3 27 Cl H CF3 S H H 1 CO2C2H 28 Cl H CF3 O C H H 1 CO2C2H5 29 Cl H CF3 NH CH3 H 1 CO2C2H 30 Cl H CF3 O i-C3H7 H 1 CO2C2H 31 Cl H CF3 O CH3 H 1 CONH2 32 Cl H CF O CH3 H 1 CO2H 33 Cl H CF3 O CH3 H 1 CO2Na 34 Cl H CF3 O CH3 H 1 CO2K 35 Cl H CF3 O CH3(H)* H 2 CO2C2H5 36 Cl H CF3 O H H 4 CO2C2H5 * ie-(CRÚRê)n - = -CH(CH3)CH2 Additional compounds of interest- and which form part of Table III above - are those in which (a) the -(CRÚRê)ngroup shown for each of the compounds of Examples 1 - 34 and 36 is replaced by each and every group selected from the following: -CH2CH2-, -CH2CH(CH3)-, -CH2C(CH3)2-, -CH(CH3)CH2-, -CH(CH3)CH(CH3)-, -CH(CH3)C(CH3)2-, -C(CH3)2CH2-, -C(CH3)2CH(CH3) and -C(CH3)2C(CH3)2- and (b) the ÚRê)n-group shown for the compound of Example 35 is replaced by each and every one of the following groups, viz -CH2CH2-, -CH2CH(CH3)-, -CH2C(CH3)2-, -CH(CH3)CH(CH3)-, -CH(CH3)C(CH3)2-, -C(CH3)2CH2-, -C(CH3)2CH(CH3)- and -C(CH3)2C(CH3)2-. Yet further additional compounds of interest - and which also form part of Table III - - are those in which (a) X = C1 in.each of the compounds of Examples 1 - 36 is replaced by each and every one of the following substituents viz fluorine, bromine, trifluoromethyl, trichloromethyl, methyl, n-butyl, nitro and cyano, (b) X1 = H in each of the compounds of Examples 1 - 36 is replaced by each and every one of chlorine, fluorine, bromine, trifluoromethyl and trichloromethyl and (c) X2 = CF3 or C1 in each of the compounds of Examples 1 - 36 is replaced by N each and every one of bromine, chlorine, trichloromethyl and tribromomethyl. Herbicidal Activity Many of the diphenyl ethers of Formula I were evaluated on the following representative species: Approximate No. Seeds Monocots: Barnyardgrass (Echinochloa 25 crusgalli) Downybrome (Bromus tectorum) 20 Foxtail (Setaria spp) 25 Johnsongrass (Sorghum halepense) 25 Nutsedge (Cyperus esculentus) 5 Wild Oat '(Avena fatuaj 20 Dicots: Cocklebur (Xanthium pensylvanicum) 3 Marigold (Tagetes spp) 15 Morning-glory (Ipomoea spp) 10 Tomato (Lycopersicon esculentum) 15 Velvetleaf (Abutilon theophrasti) 15 The following test procedure was employed. Seeds of the above species were planted in soil in trays (approximately 18 cm x 27 cm x 8 cm). For preemergence tests, the trays were sprayed with the test compound immediately after planting. For postemergence tests, the seeds were allowed to germinate and after growing in the greenhouse for two weeks, the growing plants were treated with the test compound. The compound to be evaluated was dissolved or dispersed in acetone or water and sprayed over the trays using a carrier volume equivalent to 468 (/ha (50 U.S. gallons per acre (A)) at the rate of application (in kg/ha) speci fied in the table. About two weeks after application of the test compound, the state of growth of the plants was observed and the phytotoxic effect of each compound'de termined as follows: each species was evaluated on a scale of 0-100 in which 0 = no activity and 100 = total kill and the results for the monocots and dicots separately averaged. The following table shows the results obtained for the compounds of the invention at 0.56 kg/ha (0.5 lb/A) and 2.24 kg/ha (2.0 lb/A) except as noted*: Diphenylethers - Herbicidal Activity Example Rate 0.56 kg/ha Rate 2.24 kg/ha No. ¯ Afl+ AM AD AM AD AM AD 1 42 52 10 44 77 98 23 55 2 62 58 38 93 93 98 57 96 4 2 42 33 94 0 20 20 96 5 48 39 60 92 76 99 68 98 6 45 58 43 92 83 100 50 98 7 - - - - 0 0 32 86 11 31 85 37 98 56 100 75 100 15 42 76 18 80 75 97 25 96 16 15 38 3 79 70 94 37 100 *17 73 77 43 99 72 92 46 98 18 55 55 52 100 94 99 75 100 19 27 44 10 84 90 98 25 95 20 25 44 2 54 58 82 17 72 Example Rate 0.56 kg/ha Rate 2.24 kg/ha No. AM AM AM AD AM AD AM AD 21 0 19 3 63 0 56 7 91 22a 38 46 25 89 88 89 70 100 *22b 74 88 53 96 87 99 40 100 *23 76 91 27 96 74 97 31 91 24 10 4 7 56 7 67 13 80 25 18 59 5 38 68 72 10 51 26 34 76 0 24 23 57 0 18 27 42 36 7 78 78 93 30 94 28 60 99 42 99 75 100 67 100 29 13 40 0 78 50 54 0 79 30 22 92 3 59 40 100 12 79 31 23 75 15 66 66 96 15 94 *32 79 84 28 99 *33 64 48 20 98 *34 62 58 22 100 35 45 74 35 96 91 99 64 99 36 58 72 32 98 40 82 58 95 37 48 66 34 95 86 100 58 99 * 1.12 kg/ha (1.O lb/A) GAM = Average Monocot; AD = Average Dicot The diphenyl ethers of Formula I are useful as preemergence and postemergence herbicides. Preemergence herbicides are ordinarily used to treat the soil by application either before seeding, during seeding, or after seeding with the crop and before the crop emerges. Postemergence herbicides are those which are applied after the crop plants have emerged and during their growth period. The compounds of Formula I are especially active as postemergence herbicides. Thus the invention provides a method of combating weeds, usually in an agronomic crop area, which comprises applying to the growing weeds, eg weed seedlings, or to the surface of a growth medium prior to emergence of the weeds, one or more of the diphenyl ethers in an amount sufficient to combat the growth of the weeds. Among the crops on which the diphenyl ethers of the invention can be advantageously employed are, cotton, soybeans, peanuts, beans, peas, carrots, maize, wheat and other cereal crops. The diphenyl ethers of Formula I are useful for controlling weeds in rice crops. When used in transplanted rice crops, the ethers can be applied either preemergence or postemergence to the weeds - that is, they can be applied to the transplanted rice plants and their growth medium either before the weed plants have emerged or while they are in their early stages of growth. The ethers can be applied to the growth medium either before or after the rice has been transplanted to that medium. The diphenyl ethers of Formula I can be applied in any amount which will give the required control of weeds. A standard rate of application of the herbicides of the invention is in the range from about 0.022 to about 13.5 kg/ha (0.02 to 12 lb/A). A preferred range is from about 0.1 to about 2.24 kg/ha (0.1 to 2 lb/A). Under some conditions, the diphenyl ethers may be advantageously incorporated into the soil or other growth medium prior to planting a crop. This incorporation can be by any convenient means, including simple mixing with the soil, applying the diphenyl ether to the surface of the soil and then discing or dragging into the soil to the desired depth or by employing a liquid carrier. In their application as herbicides one or more of the compounds of Formula I will usually be used in conjunction with an agronomically acceptable carrier or diluent (and optionally a surfactant) so as to provide a herbicidal composition which, in general, will contain from 0.1 to 99.9% more usually 1 to 99% and even more usually 5 to 95% by weight of active herbicidal component comprising or consisting of one or more of the diphenyl ethers of Formula I. These herbicidal compositions may be in the form of ready-for-use dusts, solutions, emulsions, suspensions, granules or pellets; alternatively they may be in the form of concentrated solutions, wettable powders, water-dispersible granules, emulsifiable concentrates, flowable liquid suspensions, flowable emulsion concen- N trates, pastes or dust concentrates each for dilution with, as the case may be, additional liquid (usually water) or finely divided solids to give diluted solutions, suspensions, emulsions, or dusts which are then directly usable as herbicidal compositions. By the term "agronomically acceptable carrier or diluent" as used above is meant a substance which can be utilized to dissolve, disperse, diffuse or otherwise dilute the active ingredient without impairing the effectiveness of the active ingredient and which does no permanent damage to such loci as soil, equipment and agronomic crops. It is usually desirable, particularly in post-emergence applications, to include adjuvants, such as wetting agents, spreading agents, dispersing agents, stickers, adhesives, and the like, in accordance with agricultural practices. Examples of adjuvants which are commonly used in the art can be found in the John W. McCutcheon, Inc. publication "Detergents and Emulsifiers 1969 Annual". Examples of solvents which are useful in the practice of this invention include alcohols, ketones, aromatic hydrocarbons, dimethyl formamide, dioxane, dimethyl sulfoxide, and the like. Mixtures of these solvents can also be used. Typical solutions contain about 2% to about 98% by weight of active ingredient and more usually about 25% to about 75% by weight. For the preparation of emulsifiable concentrates, the diphenyl ether can be dissolved in organic solvents, such as benzene, toluene, xylene, methylated naphthalene, corn oil, pine oil, o-dichlorobenzene, isophorone, cyclohexanone, or methyl oleate, or in mixtures of these solvents, together with an emulsifying agent which permits dispersion in water. Suitable emulsifiers include, ethylene oxide derivatives of alkylphenols or long-chain alcohols, mercaptans, carboxylic acids, and reactive amines and partially esterified polyhydric alcohols. Solvent-soluble sulfates or sulfonates, such as the alkaline earth salts or amine salts of alkylbenzene-sulfonates and the fatty alcohol sodium sulfates, having surface-active properties can be used as emulsifiers either alone or in conjunction with an ethylene oxide reaction product. 'Flowable emulsion concentrates are formulated similarly to the emulsifiable concentrates and include, in addition to the above components, water and a stabilizing agent such as a watersoluble cellulose derivative or a water-soluble salt of a polyacrylic acid. Emulsifiable concentrates typically contain about 10% to 60% by weight of active ingredient and flowable emulsion concentrates can contain up to 75% by weight of active ingredient. Wettable powders suitable for spraying, can be prepared by admixing the compound with a finely divided solid, such as clays, inorganic silicates and carbonates, and silicas and then incorporating wetting agents, sticking agents, and/or dispersing agents. The concentration of active ingredients in such formulations is typically in the range of from about 20% to about 98% by weight, and, preferably, from about 408 to about 75% by weight. A dispersing agent can constitute about 0.5% to about 3% by weight of the composition, and a wetting agent can constitute from about 0.1% to about 5% by weight of the composition. Dusts can be prepared by mixing the diphenyl ethers with finely divided inert solids which may be organic or inorganic in nature. Materials useful for this purpose include, for example, botanical flours, silicas, silicates, carbonates and clays. One convenient method of preparing a dust is to dilute a wettable powder with a finely divided carrier. Dust concentrates containing from about 20% to about 80% by weight of the active ingredient are commonly made and are subsequently diluted to about 1% to about 10% by weight use concentration. Granular formulations can be prepared by impregnating a solid, such as granular fuller' s earth, vermiculite, ground corn cobs, seed hulls, including bran or other grain-hulls, or similar material. A solution Of one or more of the diphenyl ethers in a volatile organic solvent can be sprayed or mixed with the granular solid and the solvent then removed by evaporation. The granular material can have any suitable size, with a preferably size range of from 16 to 60 mesh (U.S. Standard Sieve Series) and typically contain from about 2 to about 15% by weight of active ingredient. The diphenyl ethers of Formula I can also be mixed with fertilizers or fertilizing materials before their application. In one type of solid fertilizing composition in which the diphenyl ethers can be used, particles of a fertilizer or fertilizing ingredients, such as ammonium sulfate, ammonium nitrate, or ammonium phosphate, can be coated with one or more of the ethers. The solid diphenyl ethers and solid fertilizing material can also be admixed in mixing or blending equipment, or they can be incorporated with fertilizers in granular formulations. Any relative proportion of diphenyl ether and fertilizer can be used which is suitable for the crops and weeds to be treated. The diphenyl ether will commonly be present in an amount from about 5% to about 25% by weight of the fertilizing composition. These compositions provide fertilizing materials which promote the rapid growth of desired plants, and at the same time control the growth of undesired plants. The diphenyl ethers can be applied as herbicidal sprays by methods commonly employed, such as conventional highgallonage hydraulic sprays, low-gallonage sprays, airblast spray, aerial sprays and dusts. For low volume applications a solution of the compound is usually used. The dilution and rate of application will usually depend upon such factors as the type of equipment employed, the method of application, the area to be treated and the type and stage of development of the weeds.. For some applications, it may be desirable to add one or more other herbicides along with diphenyl ethers of the invention. Examples of other herbicides which can be incorporated to provide additional advantages and effectiveness include: Carboxylic Acids and Salts and Ester Derivatives Thereof 2,3,6-trichlorobenzoic acid, 2,3,5 ,6-tetrachlorobenzoic acid, 2-methoxy-3,5,6-trichlorobenzoic acid, 2-methoxy-3, 6-dichlorobenzoic acid, 2-methyl-3,6-dichlorobenzoic acid, 2, 3-dichloro-6-methylbenzoic acid, 2,4-di-chlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, 2-methyl4-chlorophenoxyacetic acid, 2-(2,4,5-trichlorophenoxy)propionic acid, 4- (2, 4-dichlorophenoxylbutyric acid, 4-(2methyl-4-chlorophenoxy)butyric acid, 2,3, 6-trichlorophenyl- acetic acid, 3,6-endoxohexahydrophthalic acid, dimethyl 2,3,5,6-tetrachloroterephthalate, trichloroacetic acid, 2,3-dichloropropionic acid, 3-amino-2,5-dichlorobenzoic acid, 2,3-dichloroisobutyric acid. Carbamic Acid Derivatives Ethyl N,N-di(n-propyl)thiocarbamate, propyl N,N-di(npropyl)thiocarbamate, ethyl N-ethyl-N-(n-butyl)thiocarbamate, ethyl N-ethyl-N-(n-butyl)thiocarbamate, propyl N-ethyl-N-(n-butyl)thiocarbamate, 2-chloroallyl N,N-diethyldithiocarbamate, N-methyldithiocarbamic acid salts, ethyl l-hexamethyleneiminecarbothiolate, isopropyl Nphenylcarbamate, isopropyl N- (m-chlorophenyl) carbamate, 4-chloro-2-butynyl N-(m-chlorophenyl)carbamate, methyl N-(3,4-dichlorophenyl)carbamate, methyl-m-hydrocarbanilate-m-methylcarbanilate, S-(4-chlorobenzyl)-N,N-diethylthiolcarbamate. Phenols Dinitro-o-(sec-butyl)phenol and its salts, pentachlorophenol and its salts Substituted Ureas 3-(3,4-dichlorophenyl)-1,1-dimethylurea, 3-phenyl-1,1-diethylurea, 3-(3,4-dichlorophenyl)-3-methoxy-1,1-dimethylurea, 3-(4-chlorophenyl)-3-methoxy-1,1-dimthylurea, 3-(3, 4-dichlorophenyl)-1-n-butyl-1-methylurea, 3-(3,4-dichloro phenyl)-l-methoxy-l-methylurea, 3- (4-chlorophenyl) -1- methoxy-1-methylurea, 3-(3,4-dichlodrophenyl)-1,1,3-trimethlyurea, 3-(3,4-dichlorophenyl)-1,1-diethylurea, dichloral urea, N'E4-E2-E-methylphenyl)ethoxy)phenyl)-N- methoxy-N-methylurea, 1,1,3-trimethyl-3-(5-ss-chlorobenzyl thio-1,3,4-thiadiazol-2-yl)urea, 3-f2-chlorophenoxy)phenyl)- l,l-dimethylurea. Substituted Triazines 2-chloro-4,6-bis(ethylamino)-s-triazine, 2-chloro-4-ethyl amino-6-isopropylamino-s-triazine, 2-chloro-4 , 6-bis (methoxypropylamino)-s-triazine, 2-methoxy-4,6-bis(isopropylamino)-s-triazine, 2-chloro-4-ethylamino-6-(3-methoxypropylamino)-s-triazine, 2-methylmercapto-4,6-bis(ethylamino)-s-triazine, 2-methylmercapto-4-ethylamino-6-iso- propylamino-s-triazine, 2-chloro-4,6-bis(isopropylamino)s-triazine, 2-methoxy-4,6-bis (ethylamino)-s-triazine, 2 methoxy-4-ethylamino-6-isopropylamino-s-triazine, 2-methylmercapto-4-(2-methoxyethylamino)-6-isopropylamino-s-triazine. Diphenyl Ether Derivatives N 2, 4-dichloro-4 '-nitrodiphenyl ether, 2,4, 6-trichlorophenyl ether, 2,4-dichloro-6-fluoro-4'-nitrodiphenyl ether 2, chloro-4-trifluoromethyl-3 '-carboxy-4 '-nitrodiphenyl ether and its salt and ester derivatives, 3-methyl-4'-nitrodiphenyl ether, 3,5-dimethyl-4'-nitrodiphenyl ether, 2,4'dinitro-4-trifluoromethyldiphenyll ether, 2,4-dichloro-3' methoxy-4 '-nitrodiphenyl ether, sodium 5-(2-chloro-4-trifluoromethyl-phenoxy)-2-nitrobenzoate. Anilides N-(3,4-dichlorophenyl)propionamide, N-(3,4-dichlorophenyl)methacrylamide, N-(3-chloro-4-methylphenyl)-2-methylpentanamide, N- (3, 4-dichlorophenyl) trimethylacetamide, N- (3,4- dichlor6phenyl)-B,B-dimethylvaleramide, N-isopropyl-Nphenylchloroacetamide, N-n-butoxymethyl-N-(2,6-diethylphenyl)chloroacetamide and N-n-methoxymethyl-N-(2,6-diethylphenyl)chloroacetamide, 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide. Uracils 5-bromo-3-s-butyl-6-methyluracil, 5-bromo-3-cyclohexyl-1, 6-dimethyluracil, 3-cyclohexyl-5,6-trimethyleneuracil, 5 bromo-3-isopropyl-6-methyluracil and 3-tert-butyl-5-chloro6-methyluracil. Nitriles 2,6-dichlorobenzonitrile, diphenylacetonitrile, 3, 5-di- bromo-4-hydroxybenzonitrile, and 3,5-diiodo-4-hydroxybenzonitrile. Other Organic Herbicides 2-chloro-N,N-diallylacetamide, N-(l,l-dimethyl-2-propynyl)-3,5-dichlorobenzamide, maleic hydrazide, 3-amino 1,2 ,4-triazole, monosodium methanearsonate, N,N-diallyl-2chloroacetamide, disodium methanearsonate, N,N-dimethyl diphenylacetamide, N,N-di (n-propyl) -2, 6-dinitro-4-trifluoro- methylanilie, N,N-di(n-propyl)-2,6-dinitro-4-methylaniline, N,N-di(n-propyl)-2,6-dinitro-4-methylsulfonylanilie, N , N -du-n-propyl-2,4-dinitro-6-trifluoromethyl-m-phenylenediamine, 3,5-dinitro-N4N4-dipropylsulfanilamide, 4-iso propyl-2,6-dinitro-N,N-dipropylaniline, N-(2-chloroethyl) 2, 6-dinitro-N-propyl-4-trifluoromethylaniline, 0-(2,4-di chlorophenyl) -O-methylisopropylphosphoramidothioate, 4amino-3,5,6-trichloropicolinic acid, 2,3-dichloro-1,4naphthoquinone, di-(methoxythiocarbonyl)disulfide, 3-isopropyl-1H-2,1,3-benzothiadiazine (4)3H-one-2,2, dioxide, 6,7dihydrodipyridol-(1,2-a: :2', 1'-c)pyrazidinium salts, 1,1'dimethyl-4,4'-bi'pyridinium salts and 3,4,5,6-tetrahydro 3,5-dimethyl2-thio-2H-1,3,5-thiadiazine, 2-(a-naphthoxy) N-diethylacetamide, 2-N-(l-napthylaminocarbonyl)benzoic acid, 3-isopropyl-lH-2,1,3-benotjiadiazin-4(3H)-one 2,2dioxide, methyl-2-f 4- (4-chlorophenoxy) phenoxy}propionate, methyl-2-{4-(3,5-dichloropyrid-2-yl)phenoxy}propionate, 2 {l-(allylOxyamino)propylidene}4-carbomethoxy-5,5-dimethyl- cylohexane-1,3-dione. When mixtures of herbicides are employed, the relative proportions which are used will depend upon the crop to be treated and the degree of selectivity in weed control desired. Typical diphenyl ether formulations follow and the abbre viation "A.I" indicates "active ingredient" which is either the compound of Example 5 or 18 or, depending on solubility etc properties, a compound which is any one of Examples 1 4, 6 - 17 and 19 - 37 particularly the preferred compounds listed in Table III. Formulations A. Solid Ready-For-Use Preparations A.1 Dusts % by weight (a) A.I. 0.01 Talc 99.99 (b) A.I. 15.0 Talc 85.0 A.2. Granules (0.5-1.5 mm average diameter) % by weight (a) A.I. 0.01 Attapulgite clay (20-40 mesh U.S. Standard Screen Series) 99.97 Octylphenoxypoly(ethyleneoxy) ethanol containing an average of 30 ethyleneoxy groups (surfactant) 0.02 (b) A.I. 25.0 Attapulgite clay (as in A.2(a) above) 65.0 Surfactant (as in A.2(a) above 10.0 B. Liquid Ready-For-Use Preparations B.l Solutions % by weight (a) A.I. 0.01 Xylene 99.99 B.l Solutions % by weight (b) A.I. 10.0 Xylene 90.0 B.2 Emulsions % by weight (a) Emulsifiable concentrate 0.05 of D.2(a) below Water 99.95 b) Emulsifiable concentrate 10.0 of D.2(a) below Water 90.0 B.3 Suspensions % by weight (a) Wettable powder of C.l(b) below 0.02 Xanthan gum (long chain poly- 0.05 saccharide obtained by the fermentation of molasses) Propylene glycol 5.0 Water 94.93 (b) Wettable powder of C.l(b) below 20.0 Xanthan gum 0.05 Propylene glycol 5.0 Water 74.75 C. Solid Concentrates C.1 Wettable Powders % by weight (a) A.IG 1.0 Kaolin 93.7 Silica (precipitated) 2.0 Sodium nonylnaphthalenesulfonate 3.0 Sodium lauryl sulfate 0.3 C.1 Wettable Powders % by weight (b) A.I. 50.0 Kaolin 21.5 Silica (precipitated) 25.0 Sodium nonylnaphthalenesulfonate 3.0 Sodium lauryl sulfate 0.5 C.2 Dust Concentrates % by weight (a) A.I. 10.0 Talc 90.0 N (b) A.I 50.0 Silica (precipitated) 40.0 Talc 10.0 D. Liquid Water-Soluble or Dispersible Concentrates D.1 Solutions % by weight (a) A.I 10.0 Octylphenoxypoly(ethyleneoxy) 15.0 ethanol containing an average of 9 ethyleneoxy groups (surfactant) Dimethylformamide 40.0 (b) A.I. 25.0 Surfactant as in D.l(a) above 35.0 Dimethylformamide 40.0 D.2 Emulsifiable Concentrates % by weight (a) A.I, 1.0 Calcium dodecylbenzene sulfonate 2.5 Surfactant as in D.l(a) above 2.5 Xylene 94.0 D.2 Emulsifiable Concentrates % by weight (b) A.I. 50.0 Calcium dodecylbenzene sulfonate 5.0 Surfactant as in D.l(a) above 5.0 Xylene 40.0 D.3 Flowable Emulsion Concentrate % by weight (a) Emulsifiable concentrate as in 2.0 D.2(b) above Water 98; ;0 (b) Emulsifiable concentrate as in 30.0 D.2(b) above Water 70.0 D.4 Flowable Liquid Suspensions % by weight (a) A.I. 10.0 Surfactant as in D.l(a) above 1.0 Sodium polyacrylate 0.5 Xanthan gum 0.05 Propylene glycol 5.0 Water 83.45 (b) A.I, 50.0 Surfactant as in D.l(a) above 2.0 Sodium polyacrylate 0.5 Xanthan gum 0.05 Propylene glycol 5.0 Water 42.45 D.5 Pastes % by weight (a) A.I) 3.0 Palm oil 30.0 D.5 Pastes % by weight (a) continued Propylene glycol 5.0 Xylene 21.0 Surfactant as in D.l(a) above 10.0 Calcium stearate 4.0 (b) A.I. 75.0 Propylene glycol 5.0 Xylene 3.0 Surfactant as in D.l(a) above 15.0 N Calcium stearate 2.0 In addition to the numerous individual compounds already identified in the foregoing description there may, by way of completeness of disclosure, also be listed the following additional compounds provided by the invention. SUPPLEMENTARY EXEMPLARY LIST EMI54.1 Compound No. X XÚ Xê Y RÚ Rê n Z 1 Br Cl CF3 O H H 1 CO2C2H5 2 I H CCl3 O H H 1 CO2CH3 3 CCl3 H Cl O H H 1 CO2Na 4 n-C4H9 Cl CF3 O H H 1 CON(CH3)2 5 n-C6H13 Cl CF3 O H H 1 CO2CH3 6 n-C12H25 H CF3 O H H 1 CO2C2H5 7 Cl Br CF3 O H H 1 CO2C2H5 8 Cl I Cl O H H 1 CO2CH2CH2OCH3 9 CF3 H Cl O H H 1 CO2C2H5 SUPPLEMENTARY EXEMPLARY LIST (continued) Compound No. X XÚ Xê Y RÚ Rê n Z 10 Cl CF3 Cl O H H 1 CO2C2H5 11 Cl CCl3 Cl O H H 1 CO2CH3 12 Cl F CF3 O H H 1 CO2C2H5 13 Cl H F O H H 1 CO2Na 14 Cl H CF3 NC6H5 H H 1 CO2C2H5 15 Cl H CF3 NCH2C6H5 H H 1 CO2CH3 16 Cl H CF3 O H H 1 CO2CH3 17 Cl H CF3 O CH3 CH3 1 CO2C2H5 18 Cl H CF3 O H H 1 Mg salt of CO2H 19 Cl H CF3 O H H 1 Ca salt of CO2H 20 Cl H CF3 O H H 1 CO2-n-C6H17 21 Cl H CF3 O H H 1 CO2(CH2)5CCl3 22 Cl H CF3 O H H 1 CO2(CH2)5CF3 23 Cl H CF3 O H H 1 CO2CH2OCH3 24 Cl H CF3 O H H 1 CO2(CH2)6O(CH2)3CH3 24 Cl H CF3 O H H 1 CO2CH2OCF3 26 Cl H CF3 O H H 1 CO2(CH2)6O(CH2)CCl3 27 Cl H CF3 O H H 1 CON(n-C4H9)2 28 Cl H CF3 O H H 1 CO2CH2CH=CH(CH2)2CH3 29 Cl H CF3 O H H 1 CO2CH2C#CCH3 SUPPLEMENTARY EXAMPLARY LIST (continued) Compound No. X XÚ Xê Y RÚ Rê n Z 30 Cl H CF3 O H H 1 CO2CH2C#C(CH2)2CH3 31 Cl H CF3 O H H 1 NHCH3 32 Cl H CF3 O H H 1 NH-n-C4H9 33 Cl H CF3 O H H 1 N(CH3)2 34 Cl H CF3 O H H 1 N(n-C4H9)2 35 Cl H CF3 O H H 1 NH2 There should also be mentioned as specific compounds within the scope of Formula I all the individual diphenyl ethers of Formula I hereinbefore disclosed but in which the -(CRÚRê)ngroup of the individual diphenyl ether in question is replaced by a different group selected from each and one of the following groups, viz-CH2CH2-, -CH2CH(CH3)-, -CH2C(CH3)2-, -CH(CH3)CH2-, -CH(CH3)CH(CH3)-, -CH(CH3)C(CH3)2-, -C(CH3)2CH2-, C(CH3)2CH (CH3)-, C(CH3)2C(CH3)2-, -CH2CH2CH2-, -CH2CH2CH2CH2-, -CH2CH2CH2CH2CH2- and each of the last three groups in which one or more of the hydrogen atoms is raplaced by a group or groups (which may be the same or different) selected from CH3, C2H5, C3H7 (all isomers), C4H9 (all isomers) and C5H11 (all isomers).

Claims: Claims: 1. A compound of the formula: EMI57.1 wherein X is hydrogen, halo, trihalomethyl, alkyl, cyano or nitro; xl is hydrogen, halo or trihalomethyl; x2 is trihalomethyl or halo; Y is O, NH, NR1 or S; R1 and R2 are the same or different and are selec ted from hydrogen, (C1-C4)alkyl, phenyl and phenyl (C1-C4) alkyl; n is an integer of from 1 to 5; and Z is carboxy, amino, monoalkylamino, or dialkyl amino; and (when Z is carboxy) agronomically adceptable salts, esters and amides of a compound of Formula I. 2. A compound as claimed in Claim 1, wherein X is hydrogen, halo, trifluoromethyl, (C1-C4)alkyl, cyano or nitro; X1 is hydrogen, halo or trifluoromethyl; This trifluoromethyl or halo; Y is O, NH or S; R1 and R2 are the same or different and are selected from hydrogen, (Cl-C4)alkyl and phenyl(C1-C4)alkyl; n is an integer of from 1 to 5; and (when Z is carboxy) an agronomically acceptable salt, ester or amide of a compound of Formula I. 3. A compound as claimed in Claim 1, and which is of the formula: EMI58.1 wherein R1 and R2 are the same or different and are selected from hydrogen and (C1-C4)alkyl, n' is 1 or 2 and R3 is hydrogen, (C1-C6)alkyl (optionally substi tuted with halo, (C1-C4)alkoxy or halo(Cl-C4) alkoxy), (C3-C5)alkenyl, (C3-C5)alkylnyl, an alkali metal cation 6r'an alkaline earth metal cation. 4. A compound as claimed in Claim 3, wherein R3 is hydrogen, (C1-C6)alkyl optionally substituted with (C1-C4) alkoxy, -CH2CF3, (C3-C5)alkenyl, Na, K or Li. 5. A compound as claimed in Claim 3, wherein RÚ and R2 are the same or different and are selected from hydrogen and (C1-C4)alkyl, n' is 1 or 2 and R3 is (Cl-C5)alkyl. 6. A compound as claimed in Claim 1, being a compound wherein (a) X is chlorine, X1 is hydrogen, x2 is 1 2 trifluoromethyl, Y is oxygen, RÚ and Rê arehydrogen, n is 1 and Z is CO2-t-C4H9, CO2H, CO2H, CO2CH2CH2OCH3, CO2CH2CF3, CO2CH2CH=CH2 or CON(CH.3)2 , (b) X is chlorine, XÚ is hydrogen, Xê is chlorine, Y is oxygen, RÚ and R2 are hydrogen, n is 1 and Z is CO2-t-C4H9, CO2H or CO2CH3, (c) X is chlorine, X is hydrogen, X is trifluoromethyl, Y is oxygen, R1 is methyl, R2 is hydrogen, n is 1 and Z is CO2CH3 or C02C2H5 or (d) X is chlorine, X1 is hydrogen, x2 is trifluoromethyl, Y is oxygen, R1 and R2 are hydrogen, n is 3 and Z is CO2C2H5. N 7. A compound as claimed in Claim 1, wherein (a) X is chlorine, X1 is hydrogen, x2 is trifluoromethyl, Y is oxygen, R1 and R2 are H, h is 1 and Z is CO2CH3 or (b) X is chlorine, XÚ is hydrogen, Xê is trifluoromethyl, R1 is CH3, R2 is H, n is 1 and Z is CO2CH3. 8. A compound as claimed in Claim 1, wherein (a) X is chlorine, XÚ is hydrogen, Xê is trifluoromethyl, Y is oxygen, RÚ and Rê are hydrogen, n is 1 and Z is CO2Na, CO2K or CO2Li, (b) X is chlorine, XÚ is hydrogen, X2 is chlorine, Y is oxygen, RÚ is methyl, Rê is hydrogen, n is 1 and Z is CO2CH3, (c) X is chlorine, X1 is hydrogen, Xê is trifluoromethyl, Y is oxygen, R1 is phenyl or benzyl, R2 is hydrogen, n is 1 and Z is CO2CH3, (d) X XÚ is hydrogen, Xê is trifluoromethyl, Y is O, S or NH, R1 is hydrogen (when Y is S), C2H5 (when Y is O) or CH3 or i-C3H7 (when Y is NH), R is hydrogen, n is 1 and Z is CO2C2H5, (e) X is chlorine, XÚ is hydrogen, Xê is trifluoromethyl, Y is oxygen, R is methyl, R2 is hydrogen, n is 1 and Z is CONH2, CO2H, CO2Na or CO2K, or (f) X is chlorine, X is hydrogen, X is trifluoromethyl, Y is oxygen, -(CR1R n is -CH(CH3)CH2- or -(CH2)4- and Z is CO2C2H5. 9. A herbicidal composition containing, as active ingredient, at least one compound as claimed in any one of Claims 1 to 8 and an agronomically acceptable carrier or diluent for the active ingredient, the composition also optionally containing a surfactant. 10. A method of combating weeds which comprises applying to growing weeds or to the surface of a growth medium prior to emergence of weeds therefrom a compound as claimed in any one of Claims 1 to 8 in an amount sufficient to combat the growth of the weeds. 11. A process for preparing a compound as claimed in Claim 1 which comprises: (A) reacting (1.) a diphenyl ether of the formula: EMI60.1 with (2) a compound of the formula G(CR1R2Z where in the above two formulae X, X1, x R1, R2, n and Z are as defined in Claim 1, E is hydrogen or nitro and D is -COC1, -COF or -COBr in which case G is HY- (where Y is as defined in Claim 1) or D is -(CO2)mM (where M is an alkali metal or alkaline earth metal and m is 1 or 2) in which case G is C1, Br or F, followed (in the case where E in the starting diphenyl ether is hydrogen) by nitration to form the desired compound, or (B) reacting (1) a phenate, or the corresponding free phenol in conjunction with an alkali metal or alkaline earth metal base, said phenate being of the formula: EMI61.1 with (2) a compound of the formula Z(CR1R2 ) nCl(F or Br) where, in the above two formulae, X, XÚ, Xêm RÚ, Rê, n and Z are as defined in Claim 1, M is the cation of an alkali metal or alkaline earth metal and m is 1 or 2. Claims: 1. A herbicidal composition containing an active herbicidal component and an agronomically acceptable diluent or carrier therefor, wherein the active component comprises one or more diphenyl ethers of the formula: EMI62.1 wherein X .is hydrogen, halo, trihalomethyl, alkyl, cyano or nitro; xl is hydrogen, halo or trihalomethyl; x2 is trihalomethyl or halo; Y is O, NH, NR1 or S; R1 and R2 are the same or different and are selected from hydrogen, (Cl-C4)alkyl, phenyl and phenyl (C1-C4) alkyl; n is an integer of from 1 to 5; and Z is carboxy, amino, monoalkylamino, dialkylamino, carboxy ester in which the ester group is agro nomically acceptable, carboxy salt in which the cation is agronomically acceptable or carboxamide in which the amido nitrogen is optionally sub stituted with one or two agronomically acceptable substituents. 2. A composition as claimed in Claim 1, wherein X is hy drogen, halo, trifluoromethyl, (C1-C4)alkyl, cyano or nitro; RÚ is hydrogen, halo or trifluoromethyl; x2 is trifluoro 1 2 methyl or halo; Y is O, NH or S; R and R are the same or different and are selected from hydrogen, (C1-C4)alkyl and phenyl(Cl-C4)alkyl and n is an integer of from 1 to 5. 3. A composition as claimed in Claim 1, wherein the diphenyl ether of the formula: EMI63.1 wherein R" and R are the same or different and are sel ected from hydrogen and (Cl-C4)alkyl; n' is 1 or 2 and R3 is hydrogen, (C1-C6)alkyl (optionally substitu ted with halo, (Cl-C4)alkoxy or halo(Cl-C4) alkoxy), (C3-C5)alkenyl, (C3-C5)alkynyl, an alkali metal cation or an alkaline earth metal cation. 4. A composition as claimed in Claim 3, wherein R is hydrogen, (Cl-C6)alkyl optionally substituted with (C1-C4) alkoxy, -CH2CF3, (C3-C5)alkenyl, Na, K or Li. 5. A composition as claimed in Claim 3, wherein RÚ, and R2' are the same or different and are selected from hydrogen and (C1-C4)alkyl, n' is 1 or 2 and R3 is (C1-C5)alkyl. 6. A composition as claimed in Claim 1, containing a diphenyl ether wherein (a) X is chlorine, X1 is hydrogen, x2 is trifluoromethyl, Y is oxygen, R1 and R2 are hydrogen, n is 1 and Z is CO2-t-C4H9, CO2H, CO2CH2CH2OCH3, CO2CH2CF3, CO2CH2CH=CH2 or CON(CH3)2, (b) X is chlorine, XÚ is hydrogen, Xê is chlorine,k Y is oxygen, RÚ and Rê are hydrogen, n is 1 and Z is CO2-t-C4H9, CO2H or CO2CH3, (c) X is chlorine, X1 is hydrogen, x2 is trifluoromethyl, Y is oxygen, R1 is methyl, R2 is hydrogen, n is 1 and Z is CO CH or CO2C2H5 or (d) X is chlorine, XÚ is hydrogen, Xê is trifluoromethyl, Y is oxygen, R1 and R2 are hydrogen, n is 3 and Z is CO2C2H5. 7. A composition as claimed in Claim 1, wherein (a) X is, chlorine, X1 is hydrogen, x2 is trifluoromethyl, Y is oxygen, R1 and R2 are H, n is 1 and Z is CO2CH3 or (b) X is chlorine, XÚ is hydrogen, Xê is trifluoromethyl, R1 is CH3, R2 is H, n is 1 and Z is CO2CH3. 8. A composition as claimed in Claim 1, wherein (a) X is chlorine, X1 is hydrogen, x2 is trifluoromethyl, Y is oxygen, R1 and R2 are hydrogen, n is 1 and Z is CO2Na, CO2K or CO2Li, (b) X is chlorine, X1 is hydrogen, x2 is chlorine, CO2Li, (b) X is chlorine, XÚ is hydrogen, Xê is chlorine, Y is oxygen, RÚ is methyl, Rê is hydrogen, n is 1 and Z is CO2CH3, (c) X is chlorine, XÚ is hydrogen, Xê is trifluoromethyl, Y is oxygen, RÚ is phenyl or benzyl, Rê is hydrogen, -n is 1 and Z is CO2CH3, (d) X is chlorine, X1 is hydrogen, Xê is trifluoromethyl, Y is O, S or NH, R1 is hydrogen (when Y is S), C2H5 (when Y is O) or CH3 or i-C3H7 (when Y is NH), R2 is hydrogen, n is 1 and Z is C02C2H5, (e) X is chlorine, XÚ hydrogen, Xê is trifluoromethyl, Y is oxygen, R1 is methyl, R2 is hydrogen, n is 1 and Z is CONH2, CO2H, CO2Na or CO2K, or (f) X is chlorine, X1 is hydrogen, x2 is trifluoromethyl, Y is oxygen, -(CRÚRê)n- is -CH(CH3)CH2- or -(CH2)4- and Z is C02C2H5. 9. A method of combating weeds which comprises applying to growing weeds or to the surface of a growth medium prior to emergence of weeds one or more diphenyl ether as defined in any one of Claims 1 to 8 in an amount sufficient to combat the growth of the weeds. 10. A process for preparing a diphenyl ether as defined in Claim 1 which comprises: (A) reacting (1) a diphenyl ether of the formula: EMI65.1 with (2) a compound of the formula G(CR1R2) nZ where in the above two formulae X, X1, X2, R1, R2, n and Z are as defined in Claim 1, E is hydrogen or nitro and D is -COC1, -COF or - COBr in which case G is HY- (where Y is as defined in Claim 1) or D'is -(CO2)mM (where M is an alkali metal or alkaline earth metal and m is 1 or 2) in which case G is C1, Br or F, followed (in the case where E in the starting diphenyl ether is hydrogen) by nitration to form the desired compound, or (B) reacting (1) a phenate, or the corresponding free phenol in conjunction with an alkali metal or alkaline earth metal base, said phenate being of the formula: EMI66.1 with (2) a compound of the formula Z(CR1R2) Cl(F or Br) where, in the above two formulae, X, XÚ, Xê, RÚ, Rê , n, and Z are as defined in Claim 1, M is the cation of an alkali metal or alkaline earth metal and m is 1 or 2.

Inventors: JOHNSON WAYNE ORRIN, JOHNSON, WAYNE ORRIN
Applicants: ROHM AND HAAS COMPANY
Application year: 1980
Main classification: C07C79
IPC codes: C07C233, C07C327, C07C205, A01N37, C07C255