INSECTICIDAL 2-SUBSTITUTED-IMINO-3-ALKYL-5-DIALKOXYPHOSPHINOTHIOLOXY-6H-1,3,4-THIADIAZINE,INTERMEDIATES THEREFOR AND PREPARATION THEREFOR

Abstract: Thiadiazine compounds of the formula (I) (FORMULA) wherein R<s1>s is alkyl, R<s2>s is alkyl, cycloalkyl, alkenyl or aryl, R<s3>s is alkyl and R<s4>s is alkyl, are useful as insecticides. The thiadiazine compounds are prepared by the addition of a dialkylhalothiophosphate to a tetrahydro-6H-1,3,4-thiadiazin-5-one. The thiodiazin-5-one precursor is prepared by reacting a thiosemicarbizide with an alkyl alpha-halothio acetate or with a haloacetic anhydride.

Description: INSECTICIDAL 2-SUBSTITUTED-IMINO-3-ALKYL-5- DIALKOXYPHOSPHINOTHIOLOXY-6H-1,3,4-THIADIAZINE, INTERMEDIATES THEREFOR AND PREPARATION THEREFOR The present invention relates to thiadiazine com¬ pounds useful as insecticides, and preparation of the thia¬ diazine compounds. It also relates to intermediates for preparation of such compounds and preparation of the inter¬ mediates. Chem. Abstr., Vol. 80, 82906p (1974), discloses thiadiazinones and their mono- and dithiophosphates. The insecticidal compounds of the invention are 2-substituted-imino-3-alkyl-5-dialkoxy-phosphinothioloxy- 6H-l,3,4-thiadiazines represented by the formula 1 wherein R 1 is alkyl of 1 to 6 carbon atoms, R 2 is alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, cyclo¬ alkyl of 5 to 6 carbon atoms, phenyl, or phenyl substi¬ tuted with 1 to 2 substituents selected from the group con¬ sisting of alkyl of 1 to 6 carbon atoms, fluoro, chloro, bromo, iodo, nitro, trifluoromethyl, trichloromethyl, tri- bromomethyl and alkoxy of 1 to 4 carbon atoms, R3 is alkyl of 1 to 6 carbon atoms and R4 is alkyl of 1 to 6 carbon atoms. Representative alkyl R 1 , R 2 -, R3, and R^ groups include methyl, ethyl, isopropyl, n-butyl, isohexyl, n- hexyl, etc. Representative substituted phenyl R2 groups in¬ clude 4-methylphenyl, 2,4-dimethylphenyl, 2-fluorophenyl, 3,5-dichlorophenyl, 3-bromophenyl, 4-iodophenyl, 2-methyl- 4-chlorophenyl, 4-nitrophenyl 3-trichloromethylphenyl, 2- methoxyphenyl and 2-chloro-4-nitrophenyl. Representative alkenyl R 2 groups are allyl, 2-butenyl and 3-hexenyl. Preferably Rl is lower alkyl of 1 to 3 carbon atoms, especially methyl. Preferred alkyl R 2 groups are alkyl of 1 to 4 carbon atoms and preferred aryl R 2 groups are phenyl and phenyl substituted with 1 to 2 substituents selected from alkyl of 1 to 4 carbon atoms, fluoro, chloro, bromo, tri- fluoro ethyl and trichloromethyl. Preferably, R 2 is alkyl of 1 to 4 carbon atoms. Preferably R3 and R 4 are alkyl of 2 to 4 carbon atoms, especially ethyl. A preferred class of thiadiazines of formula I is that wherein R^ is lower alkyl of 1 to 3 carbon atoms, especially methyl, R 2 is alkyl of 1 to 6 carbon atoms, R 3 is alkyl of 2 to 4 carbon atoms and R 4 is alkyl of 2 to 4 carbons. The compounds of the invention can be prepared by the addition of a dialkoxyhalothiophosphate (III) to a 2-(substituted-imino)-3-alkyl-tetrahydro-6H-l,3,4-thiadia- zin-5-one (II), as depicted in the following reaction (1) R 1 N S R 2 -N=C Nil + X-P-OR 3 - ( D {1) S C=0 « OR M CH 2 (II) (III) wherein Rl, R 2 , R 3 and R 4 have the same meaning as stated before, and X is chloro or bromo, preferably chloro. Reaction (1) can generally be conducted by react ing substantially equimolar amounts of the thiadiazinone (II) and the thiophosphate (III), i.e., the molar ratios of thiadiazinone (II) to thiophosphate (III) generally vary from about 1:1.2 to 1.2:1, although molar ratios from about 1:1.1 to 1.1:1 are preferred. A substantially equivalent amount of a base can be used to scavenge the hydrogen halide by-product. Such bases are preferably inorganic bases, e.g., alkali metal carbonates such as OMPI sodium carbonate and potassium carbonate, and alkali metal bicarbonates such as sodium bicarbonate. The molar ratio of base to the thiadiazinone (II) is generally about 1.1:1 to 1:1. The reaction can be conducted in an inert liquid organic diluent. Suitable inert organic diluents include alkanones such as acetone, methyl ethyl ketone; acyclic alkyl ethers such as dimethoxyethane and dibutylether; cyclic ethers such as dioxane or tetrahydrofuran; halo- alkanes such as dichloromethane and aromatic compounds such as benzene, toluene, and chlorobenzene. Generally, the amount of diluent employed ranges from 1 to 50 mols per mol thiophosphate (II). Reaction (1) is suitably conducted at a tempera¬ ture of from about 15°C to the boiling point of the dilu¬ ent, although temperatures of from about 20°C to 100°C are preferred. The reaction is generally conducted at or above atmospheric pressure. The reaction time will, of course, vary depending on the reaction temperature and the particular reactants employed. Generally, however, the reaction time varies from several minutes to 24 hours. The thiadiazine product (I) can be isolated from the reaction mixture by conventional procedures, e.g., extraction, chromatography, crystallization, etc. Reaction (1) can also be conducted with the hydrogen halide salts of the thiadiazinone (II). In this modification of reaction (1), two equivalents of the base material are generally used, i.e. , the molar ratio of base to thiadiazinone is generally about 2.2:1 to 2:1. It is generally preferred to use the hydrogen halide salt when the imino substituent (R 2 ) of the thiadiazinone (II) is aliphatic. The thiadiazin-5-one reactants (II) used in reaction (1) are novel compounds and can be prepared by the cyclization of a semithiocarbazide (IV) with a halo¬ acetic anhydride (V) , as depicted in the following reaction (2) : OMPI A R 2 -NH-C-NII-NH 2 (X CH 2 CO) 2 0 ( ID (2) R 1 (IV) (V) wherein R 1 , R 2 and X have the same meaning as previously stated. Reaction (2) is generally conducted by reacting substantially equi olar amounts of the semithiocarbazide (IV) and the haloacetic anhydride (V) in the liquid phase. The molar ratios of semithiocarbazide to anhydride (V) generally vary from about 1:1.2 to 1.2:1, although molar ratios of from about 1:1.1 to 1.1:1 are preferred. The reaction is normally conducted in an inert liquid diluent, e.g., organic solvents such as chlorinated hydrocarbons. The reaction is conducted at a temperature of from about 0° to the boiling point of the diluent, although tempera¬ tures from about 25°C to 100°C are preferred. The reac¬ tion is generally conducted at or above atmospheric pres¬ sure. Generally, the reaction is completed within one- half to 24 hours. The product (II) can be isolated and purified by conventional procedures such as extraction, filtration, crystallization and chromatography. Gener¬ ally, when the thiadiazinone product (II) has an aliphatic i ino substituent (R 2 ) , the product is most conveniently isolated as a hydrogen halide salt. The thiadiazin-5-one reactants (II) can also be prepared by reacting the semithiocarbazide (IV) with an alkyl halothioacetate (VI) as depicted in the following reaction (3) : s o R 2 -NH-C-NH-NH 2 + XCH 2 CSR -► (II) ( 3 ) (IV) (VI) wherein R 1 , R 2 and X have the same meaning as previously stated and R is alkyl of 1 to 6 carbon atoms, preferably of 1 to 3 carbon atoms. Reaction (3) is generally conducted by reacting substantially equimolar amounts of the semithiocarbazide (IV) and the halothioacetate (VI) in the liquid phase. The molar ratios of semithiocarbazide to halothioacetate (VI) generally vary from about 1:1.2 to 1.2:1, although molar ratios of from about 1:1.1 to 1.1:1 are preferred. The reaction is normally conducted in an inert liquid ' diluent. Suitable inert organic diluents include alkan- ones such as acetone, methyl ethyl ketone; acyclic alkyl ethers such as dimethoxyethane and dibutylether; cyclic ethers such as dixoane or tetrahydrofuran; haloalkanes such as dichloromethane; and aromatic compounds such as benzene, toluene, and chlorobenzene. Generally, the amount of diluent employed ranges from 1 to 50 mols per mol of semithiocarbazide (IV). The reaction can be con¬ ducted at a temperature of from about 0°C to the boiling point of the diluent, although temperatures from about 25°C to 100°C are preferred. The reaction is conducted at or above atmospheric pressure. Generally, the reaction is completed within one-half to 24 hours. The product (II) can be isolated and purified by conventional procedures such as extraction, filtration, crystallization and chroma- tography. Generally, when the thiadiazinone product (II) has an aliphatic imino substituent (R 2 ), the product is most conveniently isolated as a hydrogen halide salt. Example 1 — Preparation of 2-(3,4-dichlorophenyl- imino)-3-methyl-tetrahydro-6H-l,3,4-thiadiazin-5-one To a stirred solution of 37.5 g (0.15 mol) 2- methyl-4-(3,4-dichlorophenyl)semithiocarbazide in 200 ml dichloromethane was added 25.5 g (0.015 mol) chloroacetic anhydride. The resulting reaction mixture was heated under reflux for 16 hours, cooled, neutralized with sodium bicarbonate, washed with water, dried over magnesium sul- fate and evaporated under reduced pressure to give an oily solid. The solid was slurried with ether, filtered and dried to give 12 g of the product, as a grey solid, m.p. 118°-120°C. This product is tabulated in Table A as compound No. A-6. Example 2 — Preparation of 2-(3,4-dichloro- phenylimino)-3-methyl-5-diethoxyphosphino- thioyloxy)-2,3-dihydro-6H-l,3,4-thiadiazine A slurry of 14 g (0.048 mol) 2-(3,4-dichloro- phenylimino)-3-methyl-tetrahydro-6H-l,3,4-thiadiazin-5- one, 7 g (0.048 mol) potassium bicarbonate, and 9.1 g (0.048 mol) diethylchlorothiophosphate in 200 ml acetone was heated under reflux for 8 hours, cooled and stirred at about 25°C for overnight. The reaction mixture was fil¬ tered and evaporated under reduced pressure to give an oil. The oil was chromato raphed on silica gel using 50/50 petroleum ethyl/diethyl ether as the eluant to give 11 g of the product, as a yellow oil. This product is tabulated in Table B, as compound B-7. Example 3 — Preparation of 2-(t-butylimino)-3-methyl-tetrahydro- 6H-1,3,4-thiadiazin-5-one hydrochloride To a stirred solution of 16.1 g (0.1 mol) 2- methyl-4-t-butylsemithiocarbazide in 200 ml dichloro¬ methane was added slowly 17.1 g (0.1 mol) chloroacetic anhydride. The resulting solution was stirred at about 25°C for about 8 hours. The reaction mixture was filtered to give 14 g of the product, as a white solid, m.p. , 224°- 225°C. The infrared spectrum of the product showed car- bonyl absorption at 5.95 micron. Elemental analysis for c 8 H 16 clN 3 0S showed: Calc. Found %S 13.5 13.3 %C1 14.9 * 15.5 Example 4 — Preparation of 2-(t-butyl- imino)-3-methyl-5-diethoxyphosphino- thioyloxy-2,3-dihydro-6H-l,3,4-thiadiazine A slurry of 10.0 g (0.0421 mol) 2-(t-butylimino) 3-methyl-6H-l,3,4-thiadiazin-5-one, 11.6 g (0.0842 mol) *. : potassium carbonate and 8. 2 g ( 0.0421 mol) diethylchloro- thiophosphate in 200 ml acetone was heated under reflux for 8 hours. The reaction mixture cooled, stirred over¬ night, filtered and evaporated under reduced pressure to give an oil residue. The residue was dissolved in di¬ chloromethane, washed with water, dried over magnesium sulfate and evaporated under reduced pressure. The crude product was then chromatographed on silica gel using diethyl ether as the eluant. The purified product (6 g) was an amber oil. The product is tabulated in Table B as Compound No. B-l. Example 5 — Preparation of 2-(t-butylimino)-3- methyl-6H-l,3,4-thiadiazin-5-one hydrobromide To a stirred solution of 5.75 g (0.05 mol) 2- methyl-4-t-butylsemithiocarbazide in 50 ml dichloromethane was added dropwise 9.15 g (0.05 mol) ethyl alpha-bromothio- acetate at 25°C. The reaction mixture was stirred at 25°C for 20 minutes (slightly exothermic reaction) and then heated under reflux for 4 hours. After cooling, the pre¬ cipitated solid was filtered, washed with hexane and dried to give 7.3 g of product, m.p. 215-216°C. The compounds tabulated in Tables A and B were prepared by procedures similar to those of Examples 1-5. The structure of each compound tabulated in Tables A and B was confirmed by nuclear magnetic resonance and/or infra¬ red spectroscopy. TABLE A Compounds of the formula CH3 Elemental Analysis C H N No. R 2 m.p. ,°C Calc. Found Calc. Found Calc. Found A-l 4-Cl-jz. 143-145 12.5l 13.21 A-2 i-C 3 H 7 122-124 14.ll 13.81 A-3 n-C 3 H7 126-130 37.6 35.6 6.3 5.9 18.2 17.2 A-4 t-C H9 127-129 40.4 39.3 6.8 6.6 17.7 17.1 A-5 3-CF3-J-- 83-84 45.7 44.4 3.5 4.1 14.5 15.0 A-6 3,4-Cl 2 -jrf 118-120 41.4 40.7 3.1 3.1 14.5 14.1 A-7 ≠ 140-144 46.6 43.4 4.7 4.8 16.3 15.5 A-8 cyclohexyl 133-135 45.6 47.1 6.9 7.8 15.9 16.8 A-9 CH2=CHCH2 68-70 37.9 35.1 5.5 5.6 19.0 17.9 TABLE B Compounds of the formula I CH3 Elemental Analysis C H N No. R 2 R3 R 4 m.p. ,°C Calc. Found Calc. Found Calc. Found B-l t-C4H9 C2H5 C2H5 Oil 18.ll 17.9l B-2 n-C3H7 C2H5 C2H5 Oil 18.9l 19.4l B-3 CH3 C2H5 C2H5 Oil 20.61 20.61 B-4 cyclohexyl C2H5 C 2 H5 Oil 44.3 43.6 6.9 6.9 11.1 10.8 B-5 2-F-jz, C2H5 C 2 H 5 oil 43.0 40.9 4.9 4.8 10.7 10.6 B-6 i-CβHy C2H5 C 2 H 5 oil 39.9 38.4 6.5 6.4 12.4 11.4 B-7 3,4-Cl 2 -^ C 2 H5 C 2 H5 oil 38.0 37.4 4.1 4.3 9.5 9.7 B-8 CH3 CH 3 CH3 oil 29.7 30.2 5.0 5.0 14.8 14.6 B-9 CH 2 =CHCH2 C H 5 C 2 H 5 oil 39.2 37.1 6.0 5.7 12.5 11.5 B-10 φ C H 5 C 2 H 5 oil 45.0 41.4 5.4 5.4 11.3 10.0 UTILITY The thiadiazine compounds of this invention we tested as follows to illustrate their insecticidal activ ty. Test results are reported in Table C. Test Procedures Aphid (Aphis gossypii Glover): An acetone sol tion of the candidate toxicant containing a small amount of nonionic emulsifier was diluted with water to 40 ppm. Cucumber leaves infested with the cotton aphids were dipped in the toxicant solution. Mortality readings wer then taken after 24 hours. Two-spotted Mite (Tetramuchus urticae) : An ac tone solution of the candidate toxicant containing a sma amount of nonionic emulsifier was diluted with water to ppm. Lima bean leaves which were infested with mites we dipped in the toxicant solution. Mortality readings wer taken after 24 hours. Housefly (Musca domestica I . ) : A 500 ppm ace¬ tone solution of the candidate toxicant was placed in a microsprayer (atomizer). A random mixture of anesthetiz male and female flies was placed in a container and 55 m of the above-described acetone solution was sprayed on them. A lid was placed on the container. A mortality reading was made after 24 hours. American Cockroach (Periplaneta americana ^ . ): A 500 ppm acetone solution of the candidate toxicant was placed in a microsprayer (atomizer). A random mixture o anesthetized male and femal roaches was placed in a con¬ tainer and 55 mg of the above-described acetone solution was sprayed on them. A lid was placed on the container. A mortality reading was made after 24 hours. Alfalfa Weevil (H. brunneipennis Boheman): A 500 ppm acetone solution of the candidate toxicant was placed in a microsprayer (atomizer). A random mixture o anesthetized male and female flies was placed in a con¬ tainer and 55 mg of the above-described acetone solution was sprayed on them. A lid was placed on the container. A mortality reading was made after 24 hours. BUR _ O Rootworm (Diabrotica u . undecimpunctate Mannerheim) : A batch of 20-30 two-day-old Diabrotica eggs was placed on the bottom edge of a 236-ml plastic cup. The cup then received the following materials: (1) 66 g soil treated with 15 ppm of the test compound; (2) 15 ml water; (3) 10 presoaked (in water for 2 hours) corn seeds evenly distributed on the soil sur¬ face; (4) 66 g soil treated with 15 ppm of test compounds; and (5) 15 ml water. The cup was placed in an incubation chamber and lightly watered as needed to keep the soil damp. After 14-16 days the test cup was examined under a dissecting microscope by observing the corn roots and soil through the clear plastic walls of the cup. Control of newly hatched larvae was rated by visually evaluating the degree of corn root damage by feeding larvae in conjunc¬ tion with visible presence of live and/or dead larvae. TABLE C — Insect Control, % No. Aphid Mite Housefly Roach Weevil Rootworm Looper B-l 70 0 60 100 100 75 100 B-2 100 99 90 0 100 80 20 B-3 100 99 100 100 100 0 100 B-4 85 0 0 0 0 0 0 B-5 94 0 0 . 0 0 0 0 B-6 99 94 100 - 100 78 50 B-7 0 70 22 - 0 98 100 B-8 99 98 99 . - 100 0 80 B-9 100 50 22 0 100 100 80 B-10 98 0 0 0 0 100 80 The thiadiazine compounds of the invention are toxic to a variety of crop and household pests, in addi¬ tion to the typical pests exemplified above. Like most agricultural chemicals, they are not usually applied full strength, but are generally incorporated with conventional biologically inert extenders or carriers normally employed for facilitating dispersion of active ingredients for agri¬ cultural chemical applications, recognizing the accepted fact that the formulation and mode of application may affect the activity of a material. The toxicants of this invention may be applied as sprays, dusts, or granules to the insects, their environment or hosts susceptible to insect attack. They may be formulated as granules of large particle size, as powdery dusts, as wettable powders, as emulsifiable concentrates, as solutions, or a any of several other known types of formulations, depending on the desired mode of application. Wettable powders are in the form of finely divided particles which disperse readily in water or othe dispersant. These compositions normally contain from 5-80% toxicant and the rest inert material which includes dispersing agents, emulsifying agents, and wetting agents. The powder may be applied to the soil as a dry dust or preferably as a suspension in water. Typical carriers include fuller's earth, kaolin clays, silicas, and other highly absorbent, readily wet, inorganic diluents. Typi¬ cal wetting, dispersing, or emulsifying agents used in agricultural formulations include, for example, the alkyl and alkylaryl sulfonates and sulfonates and their sodium salts; alkylamide sulfonates, including fatty methyl taur- ides; alkylaryl polyether alcohols, sulfated higher alco¬ hols, and polyvinyl alcohols; polyethylene oxides; sul- fonated animal and vegetable oils; sulfonated petroleum oils; fatty acid esters of polyhydric alcohols and the ethylene oxide addition products of such esters; and the addition products of long chain mercaptans and ethylene oxide. Many other types of useful surface-active agents are available in commerce. The surface-active agent, when used, normally comprises from 1% to 15% by weight of the pesticidal composition. Dusts are freely flowing admixtures of the active ingredient with finely divided solids such as talc, natural clays, kieselguhr, pyrophyllite, chalk, diatom- aceous earths, calcium phosphates, calcium and magnesium carbonates, sulfur, lime, flours, and other organic and OM . A inorganic solids which act as dispersants and carriers for the toxicant. These finely divided solids have an average particle size of less than about fifty microns. A typical dust formulation useful herein contains 75% silica and 25% of the toxicant. <- Useful liquid concentrates include the emulsifi¬ able concentrates, which are homogeneous liquid or paste compositions which are readily dispersed in water or other dispersant, and may consist entirely of the toxicant with a liquid or solid emulsifying agent, or may also contain a liquid carrier, such as xylene, heavy aromatic naphthas, isophorone, and other non-volatile organic solvents. For application, these concentrates are dispersed in water or other liquid carrier, and normally applied as a spray to the area to be treated. Other useful formulations for insecticidal appli¬ cations include simple solutions of the active ingredient in a dispersant in which it is completely soluble at the desired concentration, such as acetone, alkylated naphtha¬ lenes, xylene, or other organic solvents. Granular for¬ mulations, wherein the toxicant is carried on relatively coarse particles, are of particular utility for aerial distribution or for penetr * ation of cover crop canopy. Baits, prepared by mixing solid or liquid concentrates of the toxicant with a suitable food, such as a mixture of cornmeal and sugar, are useful formulations for control of insect pests. Pressurized sprays, typically aerosols wherein the active ingredient is dispersed in finely divided form as a result of vaporization of a low-boiling dispersant solvent carrier, such as the Freons, may also be used. All of these techniques for formulating and applying the active ingredient are well known in the art. The percentages by weight of the toxicant may vary according to the manner in which the composition is to be applied and the particular type of formulation, but in general comprises 0.1 to 95% of the toxicant by weight of the pesticidal composition. The pesticidal compositions may be formulated and applied with other active ingredients, including othe nematocides, insecticides, fungicides, bactericides, plan growth regulators, fertilizers, etc. In applying the chemical an effective amount -and concentration of the tox cants of this invention is, of course, employed. The terms "insecticide" and "insect" as used herein refer to their broad and commonly understood usage rather than to those creatures which in the strict bio¬ logical sense are classified as insects. Thus, the term "insect" is used not only to include small invertebrate animals belonging to the class "Insecta", but also to other related classes of arthropods, whose members are seg mented invertebrates having more or fewer than six legs, such as spiders, mites, ticks, centipedes, worms and the like.

Claims: CLAIMS : 1 . A compound of the formul a wherein Rl is alkyl of 1 to 6 carbon atoms, R 2 is alkyl of 1 to 6 carbon atoms, alkenyl of 3 to 6 carbon atoms, cyclo¬ alkyl of 5 to 6 carbon atoms, phenyl or phenyl substituted with 1 to 2 substituents selected from the group consist¬ ing of alkyl of 1 to 4 carbon atoms, fluoro, chloro, bromo, iodo, nitro, t ifluoromethyl, trichloromethyl, tri- bromomethyl, and alkoxy of 1 to 4 carbon atoms, R is alkyl of 1 to 6 carbon atoms and R 4 is alkyl of 1 to 6 carbon atoms. 2. A compound according to Claim 1, in which R is alkyl of 1 to 3 carbon atoms. 3. A compound according to Claim 1 or 2, in which R3 and R 4 are alkyls of 2 to 4 carbon atoms. 4. A compound according to Claim 1, in which l is alkyl of 1 to 3 carbon atoms, R 2 is alkyl of 1 to 6 carbon atoms and R and R 4 are alkyls of 2 to 4 carbon atoms. 5. A compound according to any preceding claim, in which R and R 4 are ethyl. 6. A compound according to Claim 5, in which R is methyl and R 2 is t-butyl. 7. An insecticidal composition which comprises a biologically inert carrier and an insecticidally effecti amount of a compound according to any preceding claim. 8. A method of killing insects which comprises c tacting said insects or their habitats with an insectici dally effective amount of a compound according to any on of Claims 1 to 6 or a composition according to Claim 7. 9. A compound of the formula R 1 R 2 2 N=C^ NH i i S C=0 N CH 2 wherein l and R 2 are as defined in Claim 1. 10. A method of preparing a compound according t Claim 9 which comprises reacting a thiosemicarbazide of the formula S n R 2 -NHC-NH-NH 2 Rl wherein Rl and R 2 are as defined in Claim 1, with chloro acetic or bromoacetic anhydride in the liquid phase. 11. A method of preparing a compound according to Claim 9, which comprises reacting a thiose icarbizide of the formula S II R 2 -NHCNHNH I Rl O wherein R! and R 2 are as defined in Claim 1, with an alkyl alphahalothioacetate wherein said alkyl has 1 to 6 carbon atoms and the halo is chloro or bromo in the liquid phase. 12. A method according ,to Claim 11, wherein said alkyl has 1 to 3 carbon atoms. 13. A method according to Claim 11 or 12, wherein R 2 is alkyl and said compound is isolated as a hydrogen halide salt. 14. A method according to any one of Claims 11 to 13, wherein the reaction temperature is from about 25°C to 100°C. 15. A method according to any one of Claims 11 to 14, wherein the molar ratio of thiosemicarbazide to thio- acetate is about 1:1.2 to 1.2:1. 16. A method of preparing a compound according to Claim 1, in which a compound according to Claim 9 or a hydrogen halide salt thereof is reacted with a dialkyloxy- halothiophosphate of the formula I S X-P-OR 3 I • OR 4 wherein R and R 4 are alkyls of 1 to 6 carbon atoms and X is chloro or bromo.

Inventors: CLEVELAND J, EDWARDS L
Applicants: CHEVRON RES, CHEVRON RES CO
Application year: 1979
Main classification: C07D285
IPC codes: A01N43, A01N57, C07D285, C07F9