The location is very central, within easy walking distance of all of Downtown/Pearl District etc and close to all the transport connections. Despite this we didn't have any problems with noise at all. The main train station is probably just a little too far to walk to/from.
The Doblies' description of the building is spot on; surrounding buildings are modern and/or huge, and in the middle of it all stands their Victorian house. It's an office downstairs with an apartment upstairs. The style is traditional and in keeping with the house, and everything is beautifully done. It feels like you're staying in a very smart old-fashioned hotel, but you have it all to yourself! Huge comfy bed, vintage radio playing quietly on arrival, everything perfectly clean and well thought through (for example the TV that a lot of people would want is hidden discretely in an antique cabinet).
Because of a straightforward (but very secure) key code entry, you can come and go easily without needing The Doblie's to be on hand, but if you do get a chance to meet them (as we did) they you'll find them to be very charming and helpful.
The only downside is that you might be tempted to stay in the apartment all day rather than go explore this brilliant city!