We had a great time in Portland during our stay at Heart of Southeast. The home was super clean and welcoming, plus it's walking distance to some great restaurants (Por Que No is a must-visit for Mexican food) and a short drive to anything else you want to get to in downtown. I was attending a Conference at the Convention Center which was an easy 15 minute drive each day.
As mentioned in the description, the owners do have dogs which cause some noise for the downstairs unit. If you're really sensitive to noise this may bother you. The ceilings are very low, so tall people might take issue with that.
Overall, a great value compared to the hotel prices and a quaint, comfortable place to stay.