Don't hesitate - stay at The Hydrangea House. Originally when I picked the location, it was a bit further away to some of the spots I wanted to visit (across the water), but only by a 10-15 minute drive. I love this cozy residential neighborhood and how easy it is to get around. It is also very close to the Alberta district.
Erin was beyond hospitable and the communication was excellent from the initial booking, to meeting her in person, and getting an elaborate list of places to check out in Portland. The space itself is so spacious and private, much like a hotel like others have said. Make sure to bring your own toiletries, but other than that, towels and even bathrobes are provided (not to mention a lovely coffee machine setup).
You will hear footsteps above you, which signal when Erin/Havan are home or not, and it didn't bother us at all. We visited during a rainy cold month, but I'd imagine the backyard to be an oasis in the summer. Love their friendly golden retriever, George (who smiles - it's the most adorable thing!) You can tell that Erin cares deeply about providing a very special experience for her guests - choose this place for couples, solo travelers alike.