This house is absolutely perfect for trips of multiple friends and families. I slept on the main floor (queen size bed) and couldn't hear my roommates on the second floor. They had the same experience. With sleeping space in the basement, the second floor, and the loft, i am sure you can accommodate your families needs.
The location is a short walk from two grocery stores, so if you wanted to save some money by making your own meals, you are in luck. The kitchen is more than adequate to cover your dining needs. There are also a bunch of delivery options if you would prefer to dine in.
All in all, this house is a great option if you want to be on a pretty street and walking distance to some pretty cool Portland places.