Mississippi Ave was a great choice for me (first time in Portland), and Mariah and Marilyn have a very nice spot. It is definitely big enough for two, with amenities (laundry, private entrance, full-size fridge) that I appreciated. And the neighborhood is a lot of fun - restaurants, shopping, and live music nearby. Portland was not quite as walkable as I expected; I wished I had rented a car. But calling Ubers was easy enough, and the drivers were all full of recommendations :)