If you're looking for a simple place to lay your head at night after a day of doing stuff in Portland, this might fit your bill, with a couple of caveats. It's hard to beat the price! The location is decent—10-15 minute drive into town—but street parking is free and easy in front of the house. My room was private with a lock and key, had a TV (which I didn't end up using), a mini-fridge (which is handy and I did use) and even a little sitting area, as well as requisite clean sheets, pillow, etc.
The deciding factor for whether or not it might be a good fit for you is the overall vibe & split purpose of the house. I was unclear on how many of the other people in the house were AirBnB guests and how many were patients in Anne's practice, Manuel Care. If you find yourself at ease in new places and know about it going in, could suit your needs. Some of the more negative reviews sound like they may have been in a less private room or were people who have to take more care when traveling, and the vibe may be not your style. Also worth knowing going in, there are a few house rules: no shoes inside, a loose 11pm curfew(?), vigilance about lights (totally reasonable, let's all save energy and the planet), etc. Your mileage may vary depending on how you deal with rules in a new, shared space.
Also since some people appear to be residents instead of AirBnB guests, expectations as to noise levels differed. It was only one evening of the handful I stayed there, but one night a resident or guest was playing Mortal Kombat until 1am or so. I was up reading and am a heavy sleeper anyway, but light sleepers might be more annoyed than I was.
Overall, the environment is serviceable and will fulfill your basic needs if what you require is a place to crash while in Portland, but if staying somewhere quaint matters while on vacation, maybe elsewhere would work better.