The location was perfect for us, in Casco Viejo but an easy walk along the river to the Guggenheim & El Centro. Two logistical things that would be helpful to plan for in advance-key pickup is located a good way from the apartment and if you will need to park a car, there is a public underground facility that we had some difficulty locating being in Bilbao for the first time. The confusion caused by both of these was offset by a host that was very helpful & responded quickly!