Carlos & Antonio's home is beautifully decorated, very comfortable and centrally located. Carlos and Antonio also provide a wealth of reference information (e.g. maps and opening hours) in the room so that you can plan out what you might like to do including visiting the historic monuments, seeing flamenco and visiting the local spa (all three of which I did). Carlos & Antonio also provide recommendations of places to eat and drink. I tested out quite a few of them across the city and they were good recommendations (personal favourite for vegos include Taberna Antigua and Red House cafe).
Whilst Carlos & Antonio are located in the central part of the city it is still quite close to the more unique barrios across the river like Triana (ceramic museum & cheap tapas) and Los remedios (cafetin bar is good) and the Andalucian Centre for Contemporary art. It took me 30-40 minutes to walk to these locations (15-20 by bicycle).
Carlos & Antonio are also stellar hosts. I hope they will accept a second visit from a quiet nerdy Australian if I ever pass through Seville again.