Manolo's place was in an incredible location. We visited just about everywhere in Seville on foot. The immediate neighborhood is lively and fun but you are also walkable to the city center (20-25 min). We visited Malaga and Madrid and never stepped foot in a car the entire week. The public transit, trains, and our feet got us everywhere we wanted to go. Manolo's place has all of the essentials and he's a great host. Checking in just often enough to make sure you have everything you need for your stay. The bed was comfortable and the roof area was incredible. We got some great weather to enjoy both the sunshine and the spa on the roof. There are definitely stairs to navigate the apartment, but as long as you are able to navigate those, you'll have everything you need to enjoy an amazing city.
My best advice is to read the books Manolo has in the living room and really try to enjoy the local way of life. Eat on their schedule, enjoy the afternoon cervesa before the siesta, and take advantage of the night life.
We hope to visit again!