If you are questioning a stay at Juana's place, book it! She and her husband, Rafael, are very welcoming and knowledgeable about the area.
Their home is in a quiet, safe and beautiful neighborhood with several bars and restaurants only about 3-5 blocks away. While the location is not central, Juana's home is one bus and a few stops from the major attractions, making it an easy and short bus ride from all the attractions. The bus stops are next to the bars and restaurants (5-ish blocks away). If you walk to Juana's place from the plaza de armas, take the Main Street near the restaurants (Google took us along the shipping port, La Raza avenue, part of which was industrial and I wouldn't recommend walking at night. However, the walk along the main avenues passed by beautiful parks and buildings.)
Juana provides information about what to see and where to go. She also provided a lovely breakfast each morning and seemed eager to help us explore Seville and to hear how our prior day's adventure went.
Also the bed was incredibly comfortable. We would absolutely book here again.