If you're going to visit Seville, Francisco's home is the place the stay. It's located in the older district of town, but the area itself is very up and coming and full life. It is also only 15 minute walk from the city center and the Cathedral.
I didn't meet Francisco, but his wife Angeles was there to greet us. She is a tour guide and actually gave us a special run through of the city. She was very helpful and gracious. I HIGHLY suggest staying with Francisco and Angeles.