Convenient and budget priced, Manuela's place is located just about 10 minutes from the Santa Justa bus stop. It's maybe a 15 minute walk to the central sightseeing area, and maybe 30 minutes to Plaza de Espana.
Manuela's English is like my Spanish - un poco. But through google translate and a little patience it was easy to communicate.
Tip-if you're taking the EA bus BACK to the airport from Santa Justa, the bus stop is the island just in front of the bus terminal... it's not by the road like I thought originally. It's closer to the building proper.