This house is fantastic for families if you want to stay in Harlem. The great things are that for New York, there's tons of space and they have everything that you need. The beds are comfy, the place is clean (save for some spiders). Our stay was for 5 weeks, and it felt like a second home after that long.
Some things to consider before booking. They added on almost $1000 in cleaning fees (two cleanings) that were not part of the original price. That seemed excessive for us, but hey, everything is more expensive in NY!
Be careful going out in the backyard, there were tons of mosquitos that we didn't realize were there until the entire family had bites the next day.
The place is located really close to Whole Foods and the 2/3 express subway, which made it very easy to get groceries and get downtown. We found a lot of great places to eat in Harlem. While we never felt unsafe in Harlem, there were lots of homeless and drugs on the streets.
Overall, a great stay, and the host was extremely responsive and took care of every minor issue we had. I would recommend this house if Harlem is where you want to call home base in NYC!