I stayed at Ann's beautiful townhouse for five nights and I mostly enjoyed it. There are a lot of pros, but also two cons.

Ann is very friendly and helpful. She was always there when I had questions.
The location is simply great. It's only a two minutes walk to the next subway station (W 4 St). The neighborhood is charming and safe, there are tons of cafés, restaurants and shops nearby. I especially liked Amy's Bread (Leroy/Bleecker) for Breakfast and Coffee, the Risotteria (Bleecker) and the fantastic Falafel at Taim (222 Waverly Place) for dinner.
My room on the first floor was big enough and clean. The bed was comfy and there was also a small couch to sit and relax. With regard to the location it is really tough to find a Hotel room for this rate with similar amenities.

But there were also two little downsides. As a guest had mentioned before there was a light smell on the ground floor. It might be from the two cats, although there are exceptionally clean and very cute by the way. But since I slightly noticed the smell in my room and had to work there for a while, I bought a small air refresher. After that it was fine.
Second, the noise level. For New York, the room is mostly quite, since Leroy Street has almost no through travel and there is no Bus station nearby. But there is a bar vis-à-vis and another one nearly beside the house. On Friday and Saturday both seem to be opened until 4 am. Although I used ear plugs, I woke up a few times during these nights until 4. On the other nights it was absolutely no problem and the noise level from the bars was low.

On the whole I would return – but maybe not on a Friday and Saturday.