Sandra and her wonderful family were really amazing, very welcoming and king with me. The house is really clean, in a quiet neighbourhood, calm, and very close to the bus station. I spent some great moments to chat with Sandra, her husband, her very clever daughter and her so cute baby... I felt really comfortable in their place and they were always available if I needed any information.
as soon as you understand the bus/subway system in New York, it's easy to go downtown from Sandra's house, and there are buses quite often. But you must count one hour (in bus + subway) to be in Manhattan).
In sum, even if the room is at a cheap price, it's a really wonderful place to stay !