I loved my stay at Ame's place! You will get a very classic-feeling Brooklyn experience from walking through her neighborhood -- brownstones, boutiques, and delis abound, and you could easily spend a week exploring Ame's neighborhood and the surrounding neighborhoods without setting foot in Manhattan. Ame's place is very close to Prospect Park, as well, which is a great place to take a walk or run in the fall.
However! Convenience to other parts of the city is also a big plus for Ame's place. I loved having several subway options nearby, including the Atlantic Terminal. Public transit from the airport (In my case JFK) was very easy. And when I did go into Manhattan, it was a quick ride over the bridge; I was at Union Square within 15 minutes.
I found Ame's place to be the perfect homebase for having things to do in both Brooklyn and Manhattan. It was generally very quiet -- I slept with the windows open every night and didn't need to turn on the white noise I usually sleep with. There was a little construction noise from elsewhere on the block during the day, but that was about it. The bedroom itself is sunny, HUGE, and comfortable. Take some time to sit in the rockers by the window and just watch the neighborhood go by. This is definitely an older house so it has some quirks (e.g., the bathroom door sticks sometimes), but to me that added to the charm. I felt lucky to find this place, and I suspect you will too!