Isabel's place is a home. We were welcomed promptly as there was very good communication leading up to our arrival. We were shown the ropes and such and then left to ourselves. She and Chris are reachable if needs be, but your room is also a private sanctuary. Everything we needed at our base for our weekend was in the room, and the bathroom is a skip away down the hallway outside of the room. You do get keys once you check in so there's no curfew lol.
As for the neighborhood and transportation, we walked around a lot during the day and took the subway 4 from either 161 or 167 or the D and we felt safe but at night we used rideshares. Tons of shops, parks, and local eateries around.
Lastly, if you have the time, Isabel is a delight and really enjoys hosting. We appreciate you Isabel, thank you!