I have been for about 3 weeks in Esin’s home. It was a pleasure, Esin was always very nice and if I needed of something she was available to help me. The area is quiet and safe, I was often coming back home in the night (sometimes also very late) by subway/walking, and I never have problems. Instead when I was very tired i took an Uber (in night) and with about 10-15$ (depends of course where you are) you get home.
With pubblic trasport: To get Manhattan from house you need about 30 minutes (nice time for NYC!): you have to walk for about 10 minutes to arrive to subway station, then you can take line 7 and in about 20 minutes you get “time square”.