In East Harlem near the 6 train. Great location to be away from the city but close enough to be up all hours of the night for travel. I felt safe even coming back 11pm or midnight. Walking in the other direction more towards Harlem you could catch the 2 or 3 train and lots of good options for food that way. We enjoyed having a home away from home that was less busy than a hotel would be in the city. Close to Central Park and La Guardia. We took the M60 to the airport with plenty of time. I say explore past the typical Manhattan experience and visit Ted & Jenny- very nice and helpful for our first NY trip.