This airbnb is very well placed. There's a bagel shop next door and plenty of restaurants nearby. Central Park is within walking distance (if you're fit). And the conference I was attending at the Marriott Marquis was very easy to get to (ten minute walk). If you're driving in, there's a relatively cheap ($50/day after tax) parking garage on 45th that's maybe a seven minute walk away. The neighborhood also felt quite safe, despite quite a few homeless people.
Things to be aware of --- the two bedrooms run one into another with no hallway, so the person in the far bedroom has to pass through to go out or to visit the bathroom. There is also only one set of keys.
Minor inconveniences aside, this is a great place to stay while in New York.