Right in the heart of Manhattan away from the touristy and noisy areas but within a reachable distance by a short walk. 5 minutes walk to Grand Central Station which will then get you everywhere. Totally safe and lots of restaurants and convenience shops everywhere.
Free use of the business center to do some printing was especially important for me, and a gym that's mostly empty in the day! Staff and administrators were very quick to respond to anything that you needed or if something didn't work.
The only negatives are the front rooms facing the road is extremely noisy, especially with the garbage trucks, but they let me change to a quieter one. Also the wifi is not very fast or reliable which impacted some of my conference calls. But overall I enjoyed my stay and will stay again if my company sends me here again!