I had an amazing stay at Santina's on the Upper East Side. She was very helpful and friendly and really made you feel at home.
The room, especially the bed, was a relief to come home to each day - cool and very comfortable. The apartment itself was clean and modern yet still had that great, old-fashioned NY feel.
The neighbourhood is very safe, and people are walking around at almost all hours. Bars and restaurants are everywhere and it's very close to the subway and Central Park. Perfect location.
I'd definitely stay with Santina again on my next trip to NYC; that is, if I don't just move there.