Andy and TJ have a great place in a location which makes it really easy to get around. If you are visiting and want to take the subway, it is just a 5 minute walk to both the red trains (which go down the west side) and the green trains (which go down the east). We had driven into the city and they helped us find a parking garage which we could leave our car in for our 3 day stay. Also, don't be intimidated by the location being in "East Harlem." Harlem gets a bad rap, but it is actually a rather nice part of town.
The building is not incredibly nice, but it has a doorman at all hours, and the elevator works, so what more can you ask for? Their apartment is very clean and creatively decorated, and they made us feel right at home. Our only complaint was that the bed is not so large, but that was not a surprise, since the listing had mentioned it. So if you are used to going to a hotel to get a king sized bed, you cannot expect to get that here.
The few interactions we had with the guys were enjoyable and friendly, but they let us keep to ourselves when we wanted. I would recommend this place to anyone who wants to stay in Manhattan on a budget.