This is the 2nd time that I have stayed on the south slope in Asheville and I would recommend it. We had 4 adults and 2 kids (7yo, 4yo) and there was adequate space for us all. The owners were very responsive and flexible. The house was maintained well.
It is a short hike uphill to the downtown area, but less than half a mile. There wasn't a lot of noise from the bars/restaurants/bus stop at night. It is a short drive to the Biltmore and depending on the hike, only a 45 minute drive or so into the mountains.
We would definitely stay here again.