South Boston is a great base for Boston exploration. Quiet when you're staying in, but a pleasure too. When you want to do the city the transport system is good and even taxi rides are reasonable (We are a family of 4)
We like walking to explore but you might need good legs to do it all.
We like doing a hop-on-hop-off early so you can revisit sites you like. When we got home tired in the evening, Meri's place was perfect. Open plan family living in the quiet suberb.