Lance and Shelly's place is about a 10 minute or so Uber ride from the airport. It may be helpful to tell the Uber driver that you are going to an AirBnB place, as ours was confused when we arrived (when we said "it's an AirBnB", he understood and enthusiastically approved).
Shelly gave an excellent introduction to the space, as well as the history of the house and the neighborhood. Her place is a great spot to begin your Boston experience.
You don't need a car, as the nearest T stop is about a 6 minute walk away.