I rented Isaac's place for a bachelor party of nine guys. First off, don't let the picture of the house deceive you, the place is plenty spacious with lots of rooms and very high ceilings. Isaac was a wonderful host, helpful when necessary and hands off when not. The house suited all of our needs and the location in proximity to the quarter was ideal; not too far away in terms of transit but far enough that we were away from the party hysteria at night. The house is two blocks from the streetcar which made transit to and from the Quarter convenient and cheap, and for driving purposes the house is close to the interstate which made it about a twenty minute drive to the airport.
As for the neighborhood, it's not good but it's not bad if that makes sense. I wouldn't suggest walking home at night to be sure, but we never felt that our safety might have been compromised while staying there. The house is close to a Whole Foods, lots of restaurants and stores, plus one of the more interesting laundromats I've been to. If you go there ("Laundromat"), ask the owner to play some blues for you.
The only real issue that wasn't ever a true issue for us was the parking. There is no dedicated parking for the house but we still managed to park three cars in close proximity to the house and we never had an issue of any kind.
Overall it was a wonderful stay, the house was a great refuge for recovery periods and down-time, and I would highly advise renting from Isaac if you are looking for a secure, comfortable and affordable location while staying in NOLA. Isaac, thanks for everything and for being so cool.