My girlfriend and I loved our stay at Margaux & Zack's place. We both consider it the best AirBNB we've ever stayed at. We felt safe in the neighborhood, and parking was easy - usually right out front on the street. At night, the place was very quiet.
We used uber/lyft to get around without worrying about parking, but it's also feasible to walk to the street cars and take those. We enjoyed ubering/lyfting to French Quarter and walking back towards the house, hitting up Cafe du Monde, several squares, the Cochon Butcher and the WWII museum on the way.
While Margaux & Zack "like to make themselves scarce", it's clear they put a lot of effort into making the place as welcoming as possible.