Little Orange is great! We stayed here for three nights while in New Orleans for a wedding in the Garden District and it was the perfect place to relax during the bustle of a wedding weekend. While the listing describes it as "cozy", it definitely doesn't feel small when you're in it - with a full sized kitchen, high ceilings, and open floor plan it didn't feel small at all to us. Perfect for 2 people.
Location in the Garden District was nice, too. A short walk to Magazine Street, St Charles, and the wedding venue we attended at Race and Religious made it easy to get just about everywhere we needed to go. Even the French Quarter was only a 30 minute or so walk away. We had been worried about safety coming to New Orleans, but at no time did we feel unsafe in the Garden District.
Overall the visit was perfect and I'd recommend a stay at Little Orange for anyone up for a visit to New Orleans.