Had a great stay at Kaylen's. It's a good location with easy street parking, and just a 20 or so min walk to Frenchmen Street.
We walked from the French Quarter back a couple of the nights we were there, and felt fairly safe. As Kaylen and Mike mentioned, just keep you wits about you, but otherwise we felt comfortable with the nice walk.
House was spacious for the two of us, and it was great to have the AC to combat the heat and humidity. Only potential downside was the proximity to train tracks, you can hear the train passing by occasionally through the day and night. Not enough to wake us up though!
All in all, a great place to stay.