The house is beautiful and very clean. The area feels safe during the daytime, and having the streetcar two blocks away makes it super easy to get to the French Quarter. If you are going to JazzFest you can take the streetcar or even go walking (~25 mins to the Fairgrounds). At nighttime I would recommend to take a cab back, although we never felt unsafe.
Catherine is a great host and will give you amazing tips about NOLA. She stocks the kitchen with yoghourts, fruit, and bread... so at the end we felt like staying in a Bed&Breakfast. Would definitely come back!!