Karen is the best host you could wish for. She has numerous local tips. Listen to her!! The location is a bit further away from the French Quarter but the tram is only a couple of minutes away (day pass $3) or just take an Uber for $8. We had some doubts about the neighborhood when driving to her house but no worries at all. The house iiself is more than perfect. Will fit 4 easily. Everything you could possibly need is available including dishwasher and washing machine. You can even park your car behind a secured gate.
When in Nola don't go to Bourbon but go to Frenchmen street (bar Maison) eat some beignets at Cafe du monde and listen to some true jazz at Fritzel's (this one is on Bourbon though..) Go on a Swamp tour (Honey island, Slidell) to see some Gators and absolutely visit the WWII museum.