Nola in itself is a beautiful destination. We came with a family group and many stayed in hotels in the CBD and French quarter. We chose privacy and a home feel as Airbnb offers well. Bourbon street is no longer my favorite, surpassed now by Frenchmen St. Food is great most anywhere, but to each there own.
Personal thoughts: experience Mothers restaurant for sure, and the Gumbo Shop. If you're traveling for more than two days, add Deanies but skip Mullats unless you stay longer than four days. Breakfast if you eat it, cause drinking is 24-7 here, is great @ Ruby Slipper and cafe Fluer De Lis.
If you're reading this you likely are Airbnb'ing or considering and I'm going to say go for it! Don't hesitate, and when you fly into Nola (assuming) skip the cabs and go straight to Uber. You'll save money time and even rental car fees vs. parking and all else.
Be ready to walk walk walk and walk some more because there really is that much to see. If you book 1839 Esplanade, feel confident you'll get a gorgeous place whether you choose the private cottage or one the main home units. All very enjoyable and quaint for guests.
Enjoy enjoy enjoy.......