Manny's home was excellent for our small group. We came into town a few days early for a wedding. We were able to walk passed the park down to Bourbon St within a matter of minutes. There's a café literally across the street that's open 7 days a week with coffee, pastries and bagels. The driveway is long enough to fit 2 cars comfortably. The house has clearly been updated and is comfortable. There is only one shower (great water pressure!), but also a bathtub in the master bedroom.
Do keep in mind that the Treme neighborhood has been transitioning over the years. As with most areas post-Katrina and other hurricanes, there are abandoned buildings. If you are not comfortable with city life, you can certainly Uber to other parts of town instead of walking. Ubers averaged about $8 to key parts of the French Quarter even during the weekend evenings.
The Treme Community Center is right around the corner. While we were in town, there was a funeral/celebrates there for a local woman who was obviously adored. The ENTIRE community was out for hours spending time with each other, playing music, etc. I don't say this to deter you (it was the afternoon), but to show you that staying outside of the main hub of downtown gets you an inside look of what locals are like and it was a great experience.