Isaac's home is great for large groups. It's about a 25-30 minute walk from the Quarter; the streetcar is just one or two blocks away, which will also take you there. If you're heading to other areas of the city, you should plan accordingly though. Since it's a residential neighborhood, there aren't many taxis that pass by and the taxi dispatch line was unreliable--taxis arrived late or didn't show up at all (note: Uber does not operate in the city). Added bonus if you rent the house: it's just a ten minute walk from two New Orleans institutions--Willie Mae's (famous for its fried chicken) and Dooky Chase's (famous for Creole cuisine).