We had a fantastic stay at Karen's. Her home is cozy—with a very friendly cat and dog, too—and located in a neighborhood of beautiful houses. Daily homemade breakfast was delicious, and I enjoyed chatting with Karen each morning. Her openness, friendliness and attention to detail made for a memorable stay.
Her home is about a 10-minute walk to the $2 ferry, which takes you right near the French Quarter. I recommend that for getting around.