Our stay in NOLA was fantastic, and using Bywater as our base of operations made it quick to get to the neighborhood gems while leaving the craziness of the French Quarter when we wanted to. If you wanted to walk from the location in Bywater to the French Quarter (which we did a couple of times) it was about 30 minutes, and a safe path there. You should definitely check out Bacchanal's and The Country Club in the Bywater neighborhood though for a great atmosphere and excellent food/drink (thanks to the lady at Sonder for hooking us up with those tips).
The home was perfect for my wife, parents, and I as there were two floors so we had our private spaces but the common areas were large and well decorated. The home itself was a lot larger than I expected, but the amenities were perfect and everything was new and clean. It was a great place to stay, the check-in was painless with the keypad, and leaving our luggage with the management office around the corner made it easy to see a little more of the city on our last day. Definitely would recommend and stay again personally.