My husband and I were in Chicago for a conference at McCormick Place, and we stayed with Beatrice and Stefan for 3 nights. We chose their place because of its proximity to the Green Line, which goes right to McCormick. We were very pleased to find that the walk is easy--about 5 minutes from the station to their house. What we liked even more is that within walking distance there's the Conservatory (absolutely gorgeous), a really cute restaurant with a great mission (Inspiration Kitchen), a convenience store, and there's even a neighborhood ice cream truck that comes by on the street.
Beatrice and Stefan are wonderful hosts, they were very helpful when we needed a slightly early check in and even offered to let us keep our luggage with them until our evening flight. They left farm fresh eggs for us to eat and had plenty of fresh towels and sheets for us to use. Their animals are so wonderful, I didn't want to leave the baby goats! We spent a little bit of time each day with the chickens, goats, cats, and pony. Truly a unique experience in the city!
One thing I will mention is that the neighborhood does feel a bit rough around the edges at night. We were approached by panhandlers at one point and when I was walking alone I did get a bit of street harassment/cat calling. We ended up using public transportation when we were together, and if I was alone at night I would take an Uber directly to the house. However, the vast majority of people we met were friendly and kind. Just something to keep in mind if you're a woman traveling alone and nervous in a big city.