The location is excellent. Just off the Green Line, it was fast and easy to get downtown (The Loop). Other neighborhoods were also very accessible, including Lakeview, Wicker Park, and even Hyde Park. The neighborhood and house are just as they're described.
Drawbacks consisted mainly of a lingering odor in the basement and the bathroom being icy cold. While the bedrooms are heated very effectively, the bathroom was not, which made showering somewhat uncomfortable. Given how well the bedrooms are heated, it seems the bathroom could be as well.
The other guests we met were friendly but we didn't talk too much to anybody which was easy to do due to the large size of the house and how much privacy everybody has. Only on the last night did a neighbor, who must have been staying for his first night, disturb us by talking very loudly. He was in the Garden while we were in the Egyptian Room.
One more note is that guests can't lock their doors. We had no problem with this, but if security is a concern of yours, this may be something to bear in mind.