Ryan's house is a truly unique and interesting place as it clearly is a host to a long and fascinating history of both itself and the neighborhood. Its proximity to the green line that takes you straight into the downtown Chicago is perhaps its biggest convenience.
A few things to note: you probably won't find food after 8pm in the house's vicinity so if you have an empty stomach eat while you're still out. Also, although the house is far from the train, it is possible to occasionally hear it so if you're noise sensitive then ear plugs can help but I doubt it is something that would bother most people.