I really love Byron place, it is very close to the turistic area, around 5 minutes in Uber. I never used the metro because the Uber prices are awesome...between 4 and 12 dollars. I can recomended go to the Union Market closed to this place, 2 corners to get the dinner... after a busy day walking in the DC. Its a nice place full of food with good prices.
If you want to enjoy the museums i recomend be early in Capitol, Natural History and Aerospace museums....these are full and you can void the big lines.
Byron place is very safe, friendly and he is adorable. I will come back for sure.
It was one of the best experiences and cities i had visited.