If you're looking for a spot in DC to stay for the weekend, 2500 Penn is absolutely the place! The location was awesome - only 5 min drive/Uber to Dupont Circle, 10 min drive to U Street, 10 min walk to Foggy Bottom metro station. The amenities in the room and building were also great. Our room had a kitchen that was clean and had almost everything we'd need to cook for ourselves while there. Trader Joes was literally right across the street which was perfect so we could grab snacks and stuff to cook.
The staff at 2500 Penn was next to none the nicest, most accommodating people I've come across. Every person I spoke to or had a question for was just so kind and sweet.
My only suggestion is if you're going to book make sure to request parking prior to your trip because the hotel was pretty busy when we went and the garage filled up so there wasn't room for me to park there. There's plenty of street parking around as well as garage parking but if you want to be closer that's your best bet. I ended up parking like an 5 min walk away in an overnight garage and it was totally fine!