We had a great family vacation in the San Fransisco area when we stayed at Brett's place for a few days. The location is very central, and the neighborhood is quaint - small homes with unique characters.
The biggest issue we had was with parking. It was hard to find streetside parking. Caltrain is easy to access from this house, so if you can use public transit that would be ideal.
The house is close to San Bruno downtown which has some good places to eat. The house was well equipped so we were able to have breakfast before heading out each day.
I would highly recommend this place for a trip to San Francisco.