I was in South San Francisco with my family for two weeks for work and decided to go with an AirBnB for the conveniences that come with having a kitchen, washer/dryer, etc. We really enjoyed our stay and absolutely loved being in the San Bruno neighborhood for our 2 week stay. It was close enough to SF with more of a neighborhood feel. We met all the neighbors and the boys even made friends at the park that's just a short walk away.
With respect to the home itself, there were some real high points. The patio area in the back was really great. It got great sun in the afternoon and early evening so we would often enjoy dinner outside. The bedding was also noteworthy.
A couple of things to consider when planning your trip. First, parking can be a bit tricky because there isn't a dedicated spot for the home. The home can also be a bit drafty in the early part of the day.