We had a great time using this as our "home base." The place was incredibly clean, and I'm picky! William included some "extras," like coffee, tea, and bottled water, which we appreciated. (There was also laundry, which we didn't use but was a nice amenity.) For us, the location was great -- we walked to Symphony Hall, Balboa Park, and Little Italy.
William was great with communication and made the process very easy (including information about parking in the area, which turned out to not be too difficult).
Just a small note about location -- we didn't see any restaurants within a 1-block radius, and there are a good number of homeless people wandering around (which might concern you if you're planning on walking home at night). For us, these weren't a problem, and we enjoyed the central location.