A gem, in the middle of downtown San Diego. Walk a marathon like we did, or take a quick uber, it won't matter because you are so close to everything. My partner and I walked to the zoo, Gaslamp, Little Italy, Midway, and Seaport Village without any issue. This historic house was very beautiful, and provided everything we needed for a weeks long trip.
You are downtown so be prepared for noises at anytime in the morning and night, the house is older so it will creek and make noises itself, but overall has great charm.