We stayed at Mayra's place during Comic Con week. It was wonderful to have so much more space than a hotel room would have afforded, plus a full-size refrigerator and complete kitchen. The location was perfect, as we could walk everywhere. When we stepped into the secure lobby off of busy, noisy, crowded 5th street every night, it was like escaping to our own private refuge.
I would have given the stay 5 stars except for two items.
1) The shower had absolutely no water pressure. This made it very difficult to wash my very thick hair.
2) The central air was not functioning. Mayra was gracious and forward-thinking and brought in a portable unit, but it was very loud. It was impossible to hear dialogue from the TV with it on (even with the TV turned all the way up). Opening the windows instead meant hearing every restaurant fan on the block.
This is a city loft - you will hear people walking around all night. It is not a quiet retreat. It does, however, allow you to be in the center of San Diego with plenty of room. Plus, it is clean!