We stayed with another couple and their two 20 year old kids. There was enough room for all of us to be together, and have our own space.
If you have young children, there are baskets of toys, a trampoline, bikes, and a secret hideaway they will love.
This Airbnb is in a safe, quiet neighborhood that has coffee shops and restaurants close enough to enjoy a nice walk. Downtown, the zoo, Balboa Park, and Little Italy are a very short drive.
I would strongly recommend this house for your San Diego visit.