Luis' place was a phenomenal location for the price and I felt completely safe in the area we were in (in an alley). It was a quick walk (~3 min) to Pacific Beach and Mission Beach (~1min). Luis was a great host, instantly responding to any of our messages, and even letting us show up a little early and leave a little late. We intentionally didn't rent a car and parking seemed pretty difficult, but there were plenty of rentable bikes and scooters at a reasonable cost.
One thing to keep in mind for potential renters is that this place is pretty bare-bones in terms of amenities. The listing is accurate, and it's not necessarily a problem; just be conscientious of what you need to bring for your stay. There were no beach towels or toys like boogie boards, though there was a single beach chair. There were no extra pillows or blankets beyond what was on the bed. There were no hand towels, and only four shower towels, with no washer/dryer to clean them if we needed. The kitchen was reasonably stocked though, which was nice, and there was a nice TV with a built-in Roku for streaming.