Charo's place was terrific. Centrally located for what we wanted to do, while still being in a residential neighborhood. Close to restaurants and sights (Mission Beach, Ocean Beach, Sea World, Old Town). If you need suggestions of what to do or where to go, Charo is more than willing to offer up ideas.
The room itself is good for a couple, and the private entrance is nice so as not to disturb the host if you're returning late in the evening. And, to top it off, the price is definitely great.
I definitely recommend having a car for this location, as you will need it to get to the local sights.