This home is centrally-located and within easy walking distance to the marina and Gaslamp District attractions and dining. West of this location on F and G Streets, large encampments of homeless people obstruct the sidewalks. If you are uncomfortable with this urban reality, take Market Street or Broadway instead ... or take Uber, especially at night.
We liked the layout (one couple upstairs in a double Murphy bed and one couple downstairs in the king-size bed, each with their own full baths). Just be aware that the front entrance opens onto the downstairs bedroom; if this is your room, folks will need to pass through it to come and go from the house.
The large central floor, with generous kitchen and lots of seating, is the showcase feature of this property. If you want a space where you can relax, unwind, or dine with several friends, this is likely your best choice in the area.
Some odd touches aside (the owner operates thermostats remotely, and must be contacted if you wish to make adjustments, for example), we can confidently recommend this location, especially for shorter stays.