We had a great experience renting from Stephanie in Pacific Beach.
Stephanie was very responsive, friendly and professional. The house was very nice and recently renovated. It was well-cleaned for our arrival, which went very smoothly. All the bedrooms are good-sized. Wifi is very fast. The neighborhood is quiet and residential, within easy walks of Mission Bay or Pacific Beach, and lots of places to eat.
If you have a big SUV, parking can be a bit tight in the garage - but it's still manageable, and there's a decent amount of street parking too.
We had everything we needed for the beach, and everything imaginable for our kids - this was key. Traveling with kids can be challenging, but when the house has a baby gate, a stroller, a high chair, a crib, cups/bowls/utensils, a pack and play, lots of kids toys and books, it makes things a lot easier. Also, the house itself isn't rife with child hazards, as vacation rentals usually are - so we could kick back and relax and not worry about our two small kids getting into trouble.