What an amazing place. I hate to tell you about it because I want it to be available every time I visit San Diego. Seriously, if you have the chance to stay here you should.
First and foremost this is not a party house, so if that's what you're looking for, you should look elsewhere. It's way too nice for that and is better suited for a family or people who are looking for a nice quiet getaway. It is well-furnished (quality like you would have in your home, not just a rental) and had everything we needed with thoughtful touches throughout. There was plenty of bottled water, nice plush towels, and wow this place was so clean!
This home is minutes to the airport and is accessible to everywhere you would want to be in San Diego from Old Town, to Downtown, to the beaches. (BTW, you'll want to shop at the Vons or Trader Joe's. The Ralph's down the street wasn't so great).
The owners are super kind and helpful, so if there is anything that you need during your stay, all you have to do is ask. They are very responsive and available, but are careful not to bother you otherwise. It's up to you how much interaction you have.
Honestly, this felt more like a friend invited us to stay over at their place while they were away than a rental.