This Airbnb is centrally located in San Diego right next to Little Italy. Close to tons of restaurants, cafés, shops, etc.
The only downside that I had for this Airbnb is that it is located right next to the airport, so close that you can hear planes coming in and out all night long. So if you are a light sleeper I would highly suggest bringing a pair of earplugs.
Other than that it is safe, clean and accommodating.