The house was spacious, clean and very convenient for all our Mission Beach, Sea World and Balboa Park activities. It was comfortable at night but with no A/C it would have been very warm in the house if we had been there during the day (August can be hot in SD too!). We did not feel comfortable leaving the windows fully open at night (they could be partially left open given they all had security latches) so it was still pretty warm (see more on security below). Also the weather and foliage around the front and back of the house led to numerous green Japanese beetles buzzing around the house. It's two long blocks to the bay park and bay beach so don't think this is right near the beach.
They only had network channels on the TV (no ESPN, Disney Channel etc.) But there was Netflix so that helped when the kids wanted to watch a kid show.
The crown point neighborhood certainly has degraded a lot since since I lived in SD in the 90s. We didn't feel secure walking around at night when we ventured out to dinner walking toward Grand and Garnet. I hear it's an urban mystery as to the significance, but we still saw three sets of baby shoes hanging from three different power lines in the area. There is no garage parking so do not leave any valuables in your car.
Also our excitement for hanging out in the very nice back yard was tempered by the notice that the house has a very noise sensitive neighbor that likes to shout directives over the wall to be quiet down as early as 9pm in the summer. As we have young kids we weren't planning to throw an all night party but we found ourselves very spooked by the notice the owners left us in their rules binder regarding this neighbor who did give us a stern look as we were unloading our car.
If you are someone who is sensitive to fragrance you might want to ask in advance if the sheets and towels can be cleaned without scented detergent and fabric softeners. They were clean but had a very strong scent. There is no washer or dryer on site.
If the above issues aren't issues to you then the location is fantastic for your San Diego proper activities.