Probably the best location you could ask for if you want to be in the thick of Little Italy. It is right next to all the restaurants, bars, and a mere 3 blocks away from the Harbor (great to walk along!).
My partner and I stayed for a long stay (4 weeks) and found that the kitchen was serviceable but could use some more utensils, dishware, and cooking equipment (pots/pans). Rachel was very responsive and got us a few of those items as needed. We also needed a second desk and chair and they quickly got us those things to help us with our work from home setup. The space is quite open and the upstairs lofted bed setup is great for keeping your sleeping area separate from your living area.
The noise level is a little high for anyone who is a light sleeper. The airplane noise is infrequent and a low rumble, but the train tracks 2 blocks away were the most disruptive in the early mornings and nights. We unfortunately stayed while the housing complex across from the unit was under construction but when that wasn't going on it was easier to sleep in. During the day there was very little disruptive noise but at night if you are a light sleeper this might not be the spot for you.
Overall, amazing location, bit too noisy (street + train + construction noise) to sleep in, open spaces in the unit and great for exploring San Diego during COVID times