We had a nice time at Skyler and Madi's place. You have great access to all the Little Italy joints and even though you're really close to the 5, I didn't notice the noise at all. The only issue I'd note, which others have commented about as well, is that the place could use a lot of TLC.
Just be aware that it's more run down than the pictures reflect. But that in no way kept us from having a nice stay.