This place is a great location for exploring downtown San Diego. Gaslamp is just down the hill, less than 10 minutes walk. Petco Park is easily accessible, and the marina is just a little bit farther. If you're someone who doesn't mind walking, then Balboa Park and the zoo are within reach too. You've got to drive or take the ferry over to Coronado, which is where we chose to go to the beach.
The airport is a quick ride away, though we ended up walking from a breakfast spot in Hillcrest (which was about 45 minutes, so even farther north is fairly easy to get to). Checking in was seamless, and the place has the necessary basics - mini fridge, coffee machine, shower with hot water, and a pretty comfortable bed. You're on the street level, so sometimes it feels like people are looking straight into your room but there are curtains to fix that.