Mireille's guest house is a great location for a quiet getaway. This is the second time that my wife and I have stayed there and we brought our baby along as well. The neighborhood has continued to grow since we last visited and we love it even more. Wonderful restaurants, the historic Craftsman House district, Balboa Park, etc. are all walkable. The Zoo is a 5-10 minute drive and the Airport is about 20 minutes.
The guest house was everything that we needed again as well. Would love to stay again the next time we go to San Diego.