Our family of four made this North Park house our 'home base' for our week-long San Diego vacation and loved it. Each of the three bedrooms has a it's own bathroom which was nice for our family, and had everything we needed to cook some meals in addition to lots of relatively close take-out options.
The North Park neighborhood is super cute and has lots of trendy shops and restaurants (and a street fair every Thursday?). Lots of other options a short drive away also. The zoo and Balboa park are a 5-minute drive, and hardly any San Diego destination is more than 15 minutes away even in CA traffic :)
Others have mentioned the parking situation - it's very do-able, but I would not recommend trying to park a large truck or SUV on premises. The (very charming) street is basically a wide alley which allows street parking on one side.
Stephanie was very responsive - we had an issue with the smoke detectors during our stay and it was resolved immediately and without any hassle at all.
Highly recommended for families! If you're with a large group that has several cars, parking an RV, or planning to host a party I would look to other listings.