If you're looking to go on a short weekend trip, I definitely recommend this place. My boyfriend and I wanted a relaxing weekend in San Diego, and that is the experience we got. There is plenty of parking, and the place is pet-friendly.
In terms of proximity to everything, it is about a 10-15 minute drive to all of the main areas (i.e., Gaslamp, Coronado Island, etc.) There is a small downtown area that is a short walk from the house. It is also easy to catch an Uber & Lyft. It was about a $7 ride to Gaslamp.