Seneca's place in North Park is very comfortable, and couldn't be better situated if you want to be within walking distance of almost every restaurant cuisine, movies, and lots of walking and available bike lanes. They are close to the freeway, so easy access to beaches and the rest of the San Diego area. We really enjoyed our stay, very clean, super easy check-in and check-out, and great entertainment options if you just want to stay in and rest.
A couple places to check out: Tabu Shabu across the street - no reservations but excellent Japanese shabu-shabu; Crush - a new breakfast place on University, a little over a block away; and Subterranean is another cozy spot for breakfast and a great selection of coffee and teas. We'll be staying here again next time we're in SD.