This is one of the most beautiful homes I've seen/stayed at. The art everywhere tells the story of the owner's life and it very aesthetically pleasing without being kitsch. This would be my first choice for a weekend getaway if I were to go to San Diego in the future.
As for being good for business trips/extended stays, I can't recommend it. There is very little room to work, the Internet connection is slow (10Mbps down, 500kbps up), and you can't really unpack or hang anything. The closets and dresser are full, which is a problem when you're supposed to hang a suit up that will be required for client meetings. I can't/won't mark the overall rating down for this for the simple reason that I don't think this is meant for those types of stays. I would not choose this for a business trip again.
The apartment was clean and well maintained. The owner left me alone (I'm antisocial and this is a necessity for me) but was available if I needed assistance. For a short personal weekend trip, I would definitely recommend this place.