Betsy's place is a nicely centrally located. It is in a nice quiet neighbourhood, but still only 10-15 minutes away from the centre by car. The only downside I can mention is that since it is close to the airport and the train station you can hear planes fly by and trains honk, however it did not distract me from my sleep (although I normally am a bad sleeper). All in all, a great place to stay at when visiting San Diego!