My wife and I brought six teenagers with us, and we all had a great time. Although I wouldn't recommend kids walking around the neighborhood, it was centrally located for all of the things we wanted to do like going to the zoo, Padres game, beaches, sea world, and old town. There's a really nice area with hip restaurants and brewery about a mile away that was perfect to give the kids a break from us after feeding them. :-)
It was also good to have Costco, target, and grocery stores close by to pick up anything we needed during our stay.