The house itself is great, 4 big rooms and 3 of them with good sized en-suite bathrooms (plus an additional big bathroom).
The location is a blessing and curse. It was within walking distance to Little Italy and the Waterfront and a 5 minute drive to the zoo and seaport village. The downside to this great location is how NOISY the place is. You're between 2 major streets so there's all sorts of street noise, but the worst of all is the house is on a landing flight path. So every 5 minutes a plane flies very low over the house. It stops at night (11pm-6am) but otherwise it's impossible to enjoy any peace and quiet. I understand this is not the fault of the homeowners in any way, it's just a reality of the location.
The biggest problem that can be controlled is that there's a downstairs neighbor that smokes pot, so the house reeked whenever they did it. Some nights were fine, but others were so bad it was making us nauseous.
The only other major issue was the parking. We were told we can't park on the property and we had to park at the hotel across/down the street. It's only a minute away so it wasn't a huge inconvenience but something to note.
On the whole though, it was a good place. The central location was great to see everything we wanted in SD, the house size was also very good and the owner provided adequate amenities (soap, shampoo, Netflix, etc.). I would stay again, but just keeping in mind some of the issues I mentioned above.