I recently spent 10 days at Alex and Daniel's house in the Castro. The location couldn't be better. Muni is a block away so you can be downtown in 20 minutes and there are plenty of restaurants and coffee shops practically outside the door!
The room is quiet since it's in the back of the house. Alex and Daniel are very attentive to your needs and also very respectful of your privacy. The room was very clean and beautifully decorated and comfortable as well.