My friend and me, we had a lovely stay (2 nights) at Lisa's place. It is very well located in the heart of Mission District, which can be explored best by just walking around. The room is cosy and nice.
Make sure you grab a burrito at taqueria el buen sabor, rent a bike at mission bicycle (anyway the best idea to explore SF by bike) and have a nice breakfast at Atlas Cafe.
Thanks a lot!