I stayed seven wonderful nigths at Alex&Daniel's place with my five years old daugter.
We loved the neghiberhoods which is charming and friendly. There are many fancy shops and restaurnats near by with walking distances.
The downtown and many of the tour points are easilly accessible by muni metro and F-line streetcar.
Pros) You can feel the real living life of San Francisco in a beautiful vitorian style house
Cons) The bed was a bit too soft for me. This may vary from the different tastes of the guests I guess :)