The 5 days at my conference (at Moscone) were an absolute breeze because of the peace that I experienced at Niels's airbnb. The comfort levels are very much at par with a 4-star hotel. Even if you've forgotten some essentials Niels has you covered (snacks, toiletries, coffee)
I would absolutely recommend this place for business travelers as it offers peace of mind, and close proximity to Moscone Center.