The location is peaceful and is walking distance to a lot of good restaurants, a bookstore, coffee shops, and a Whole Foods for groceries. It's also a short walk to the Mission and the Castro neighborhoods (be prepared to stretch your calves as you climb the hills out of Noe Valley)--and there is public transportation nearby, as well. The apartment is a beautiful old Victorian, with very high ceilings, but with contemporary bathrooms and kitchen. The shower has good water pressure and the kitchen has very good appliances.
We encountered a couple of maintenance issues (as will happen with old buildings sometimes) and the hosts were immediately responsive.
It's a lovely place to take a vacation. The one caveat is that if you plan to do work online while in San Francisco, the WiFi in the apartment is rather weak.