325 Sutter is a wonderful, old-fashioned hotel repurposed for modern travel needs. I loved staying here, from the extraordinarily comfortable bed (seriously, how is it so comfy? I didn’t want to get up) to the immaculate bathroom (super clean, warm shower with great water pressure). The faux hard wood floors felt great as I padded around and worked on my computer, the desk set up for my work was ergonomically perfect.
I stayed on the fourth floor away from the street (and as far as one can get from the elevator, stayed next to an elevator at a Marriott once and it was a mess). I never heard any other guests, I never had any issue and I felt enormously safe (which for some people might be a concern with the homeless population in the neighborhood).
This is closer to the gentrified sections of the Tenderloin District and, as such, less sketchy than if you were west of 5th. The facility itself is an oasis of modern conveniences and pristine surfaces with a hint of the early twentieth century for ambiance. I would stay at this facility again without reservation.