Although the location is not in the center, I found it was easy and quick to get into the center via the tram/metro system. 1/2 block from the front door you have a "J" tram stop (which does directly into the "J" metro line - so no need to change) - so very convenient. Or you can walk a couple of blocks and get straight onto the Metro - plus buying an x day visitor pass made it easy to get from the front door to anywhere in SF.