The Inn at Noe Valley is probably the most immaculate house I've ever stayed in.
Vincent is very clear on a couple of simple rules, and it's easy to respect those because in return you receive an immaculate and well-cared for home.
I stayed on a business trip, and it felt like I was in a private suite. The floor plan is open and spacious - rare for a Victorian. Vincent takes special care to make sure each possible need is met - and is on call to check in without making it seem like he's just over your shoulder.
Noe Valley + The Castro is an excellent area. I wish I had more time to explore the coffee shops and restaurants, but Vincent provides an excellent overview of the neighborhood.
If you're a first timer in San Francisco, you know to pack comfortable shoes. This is especially true in Noe Valley, which is very hilly and beautiful.