The house is in a really nice neighbourhood, gated community feel without the gates, I felt perfectly safe there as a solo female traveller, even walking home at night.
The location, while not in downtown, is very convenient. I suggest you download the Muni app before you leave the house and purchase a $5 day pass. You activate it through the app before getting on transport for the first time then it is active all day and you can hop on and off any muni transportation.
There are two ways to get around. Either walk 10 min to the shopping centre and catch a bus 28 that will take you directly to the Golden Gate Bridge (roughly 30min) or walk 5min to get a light rail that takes you towards town. I got off at Van Ness and walked to the painted ladies.
Google maps is your best friend to work out connections.
(Note muni day passes don’t include cable cars or bart but you can easily get around without them).
Also one thing to note, Sally’s two children live at the property, Sally was not staying there during my stay so the vibe was more of an early 20s houseshare. This didn’t bother me but may not be what you had in mind. Bring earplugs as noise travels in older houses.
The room is very comfortable and a nice size, the toilet and bathroom are just across the hall. BYO toiletries.
I would recommend the place as a convenient, safe, comfortable and affordable stay from which to explore San Francisco.