We had a good time in Burbank, the hosts were very friendly and we felt very welcome. (Thank you!) They helped us out with all our questions and they gave crayons to our son. The garden is amazing and we could even sample from the tangerines.
The guesthouse is also conveniently close to Caltech (about 30 min with traffic), so ideal if you're a visiting researcher. Many shops and restaurants are at walking distance but most would prefer a car because the way back is a little uphill. I would definitely recommend this place for (small) families.