I've been renting a room for the last 6 months and I just renewed for another 6 months mostly because it's cheap and in a central location.

Cleanliness:
My room has hardwood floors and it was dusty/dirty moving in but it's an old building so it's to be expected. Bathrooms are again old, occasionally you'll see shit stains and toilet-paper stuck on the seats but they are cleaned I believe daily to sanitary standards. Showers are usually clean but you'll probably see another person's hair... bring flip-flops or shower-sandals for hygienic reasons. Kitchen is old as well and the ventilation sucks but you can microwave shit, there's a stove, and a toaster oven - fridge is tight with limited space.

Occasional fruit fly will appear if you eat a banana in your room and leave the window open.

Safety:
You are downtown and relatively close to skid-row yet in sort of the Arts District area so you should always be aware but it's somewhat safe. The worst thing to happen to me was just recently in which my bicycle wheels, handlebar, and stem were stolen from my bicycle which was locked just outside the building (the frame was essentially left with my lock as I didn't lock my wheels). I park my motorcycle on the street and so far nobody has fucked with it to my knowledge.

Noise:
There's the train the runs just across the street so that can be annoying as the windows are paper thin in terms of letting noise in.

Weather:
It can get pretty warm mid-day if you are facing the sun but at night it cools down to comfortable-sleeping levels.

Price:
Cheap, in term's of Yelp it would be a "$". ($$$$$ = would be the priciest)