Jame's place is a great little spot nearby the main Ishtiklal shopping/eating street, but also very convenient to the cool spots in Galata and Karakoy. This part of town is best explored by foot, but you're close to both the tram and the train across the Horn down the hill.
The flat itself is very cool, great architectural details and very stylishly designed, it's one of the more unique and custom apartments I've stayed at on this site! The view from this 2F unit is quite amazing, you can see it anytime you're in the living room but also from the cute balcony, as you're high enough on the hills to capture a great look over the hills and to the Asia side, with just a peek of the Bosphorus. The apartment is also quite large with plenty of space for two people and for different activities, just keep in mind as others have noted that the bathroom is not too private from the bedroom so works best for a couple or close friends. Keep in mind Istanbul is very hilly, and in this area of town you're going to be up and down a lot of steep small streets, but lots to explore and see! Definitely check out the nearby Kilic Ali Paşa Hamam if you're looking for that experience.