Rey's place was a cosy oasis away from the noise and bustle of city life, I stayed here and felt very at home for 2 weeks in September.
It is very quiet compared to most other locations but still is super close to walk to Taksim square Metro, local grocers, the bus to the airport is a 10-15 minutes walk, and it is also very close to the T1 tram to all the Touristy places like the Grand Bazaar/ Hagia Sofia/ Cistern Basilica and the F1 furnicular tram (if you don't like walking up hills!!)
That said if you have mobility issues or are a wheelchair user it would not be suitable (stairs and some steep paths coming down from Taksim square) but otherwise if you are fit and mobile this is a perfect place to stay in Istanbul that gives access to touristy things as well as more local neighbourhoods, restaurants, shops and cafes. Highly recommend!!!