Central location: we could reach almost everything on foot from there - even with two kids (5 and 10 years). Well equipped apartment: occident meets orient. Very accommodating host: with many practical tips about food and excursions, Istanbul guidebook in different languages (English, German and French) and very quick response to all questions via Whatsapp or Airbnb.
Conclusion: it was a good time in Istanbul, only the location was a little too busy for us. But that was self-chosen.