Located near the Asiatique this place is a hidden gem. The host was very kind to arrange us a taxi early morning and her sightseeing tips- a written note left in our room was very helpful. She was also very quick with her responses. I would recommend Ms. Oranee's if you are looking to experience Bangkok's fantastic local food scene and local businesses, its vibrant night life, the great hospitality of the people and its various modes of public transport on an intimate level.
We enjoyed our trips to town on the boat express from Pier Rajsingkorn that took us away from the traffic and is connected to the BTS at Saphan Taksin (a couple of stops away).
Regarding accessibility: There is a flight of steps to the room and the bathroom is located on the ground floor.