I've stayed at 30-40 hotels/hostels/airbnb in Bangkok. This is one of the coolest I've stayed at. Meow-chan has put a lot of care into the little design + comfort details when turning this old shophouse into a cafe/bed space and providing Airbnb service (like preparing us obento on our last morning since we were catching an early train!). Really special place!
As for the location, this neighborhood has become quite hip in the last few years so there are lots of cafes and bars to explore in addition to the long-standing thai-chinese restaurants and cultural points of interest. And it's close to Ratchawongse pier for easy transit.