I've had a great stay here, planning to be a regular guests.
To explain, there are 3 modern city centers in Bangkok: Silom/Sala Daeng (Si Lom MRT), Siam Square and Asok (Sukhumvit MRT) – this house is close to all of them. If you locate each of the three centers on the map and visually connect them – you will easily notice that Bangkok’s gem - Lumpini Park is the center of all Bangkok – and this house is 900 meters from it.
The closest subway station is MRT Lumphini (dark blue line), next to the park , so 800 meters from the house (8-12 min walk or 1 min motorcycle ride for a few coins). The MRT is useful for trips to and from the airports, Hua Lamphong train stations, Chinatown, Terminal 21, Chatuchak Weekend market, etc. The building is in an old town-house/shop-house in a residential area and it is the most traditional Bangkok neighborhood that is close to the city center.
Don't worry that it's far from Khao-San road: unless you'd like to experience the feeling of being ripped off by scammers, no authenticity but lots of drunk backpacker tourists, you don't want to go there.