We chose Plaza Santa Ana because it is a great central location (Plaza Mayor and Prado both within a walk) with a nightlife itself. The property has amazing character, is beautifully presented and you are able to watch life in the square from the balconette. If you want a really quiet place then this may not be for you as the square is bustling until late, but if you want to experience Madrid life this is perfect. We stayed with our two young boys who loved the apartment, their bedroom and the experience of walking around the city in the evening. Great city break.