Great facilities, room cleanliness and helpful online/offline staff. Might need a little time getting used to the check-in process but it isn't complicated. Keep in mind that there is only the ONE kitchen in this block so don't go in expecting to be making pancakes and omelettes every morning. Depending on where your room is, noise from the outside shouldn't be a huge problem and what noise does filter in is pretty benign and doesn't linger past 12 am.
Location is excellent as it is smack dab in the middle of some of the best cafes, restaurants and bars. But best you make some reservations for brunch/breakfast during weekends cause it can get quite busy and places rarely have the ability to accomodate walk-ins. Mind you, it is not so far from the Guoco tower and the Tanjong Pagar MRT where there are a few comparatively cheap restaurants and one not so cheap organic market shop (if you're keen on buying fruits and the like).
I'd ST Signature is ideally situated if you want to go to experience all the major sights and sounds Singapore has to offer. Main mode of transport I recommend using would be the MRT, which is fairly easy to navigate, or the transportation app GRAB.
All in all an excellent choice if you're travelling solo or on a budget but still like to immerse yourself in all the city has to offer.