My wife and I loved Karen’s place. The location was not too far from the central area, but just far enough to come back to a quiet, calm and clean room. The room or shall I say loft like space is really cozy and comfortable. One night we just stayed in after a long day of traveling. The neighborhood is also so lovely with plenty of local stops. The bar around the corner, Bar Centraal has a great vibe, and they have a wonderful selection of wines.
Some reviews have already mentioned the steep stairs so I was mentally prepared, but I just want to stress to the next visitor, the stairs are extremely steep, small and narrow. (I think this is normal for Amsterdam). You might have a difficult time if your suitcase is large and heavy.
Other than that, I would recommend Karen’s place if you are looking for a getaway from a getaway.