I recommend this location. It’s perfect to explore Mexico City. The host are always a message away and this place has 24/7 security so you will feel safe. The security guards are very nice.
From this location your are close to La Condesa, Polanco, and other places you are planning to visit.
The Ubers arrive within 5min. And they are affordable. I recommend you Uber to the locations you wish to visit.
There is a lot to see and culture to discover.