Just FYI, I've stayed in this small room twice--the first time for several weeks. Soooo, I know the area. I've walked to the center of Coyoacan dozens of times (from the room) and it's a pleasant walk. 'About 20 minutes or a tad longer. I've also used the subway which is a stone's throw away. 'Very, very convenient. Oh--and Uber, coming and going. The Mexico Sur bus terminal is also nearby. The neighborhood is safe. If you really love to walk, you can use the nearby Line 2 or if you'd like to jump on Line 3, it's within walking distance, too--but more on the order of a 35-40 minute walk, across Coyoacan. I'm 70 and I've done it many, many times (for convenience when traveling to specific locations in CDMX), but you do have to enjoy walking. (One tip: Amatista, downtown, for soup, tostadas, and agua del dia, etc. They open at 1:30 and it oftentimes fills fast (it's a tiny restaurant). BUT ... good food and very, very, very reasonable.)