I really loved my time at Vicky and Pablo's place, and I'm sorry I couldn't have stayed longer. They were very gracious hosts and Pablo gave me some excellent tips for places to eat and things to do in the neighborhood (I highly recommend tacos and tepache at El Borrego Viudo, which really made a long day of travel all worth it).
The location is great. Escandon is not as built up as La Condesa and Roma, but is close to those neighborhoods and is still safe. At night it's pretty quiet as far as Mexico City goes. Neighborhood choice is all up to personal preference, but for me this was a good match - I liked the feel of it more than La Condesa where my friends were staying.
The place itself is wonderful - homey, bright and with lots of wood and plants. It's a loft atop the hosts' residence, so you have to walk through there in order to get to it, but I considered that a bonus. I would often run into Vicky or Pablo (or their super-friendly pets) and discuss what I had done in the day and get more ideas for things to do the next. There's a very narrow spiral staircase which might make luggage difficult, and if you have accessibility concerns this unfortunately probably rules it out entirely. Water does not flow very freely, but as per my understanding this is common in CDMX. Oh, and if you leave the door open Carlitos the cat will eventually visit you.
In all I had a wonderful stay and would happily return!