Casa de Chiles was a wonderful place to stay for my first trip to Mexico City!
Location wise, I could not have asked for anything better. Cuauhtemoc is smack dab in the middle of Polanco, Chapultepec Park, La Condesa, La Roma, and the Historic District. Most Ubers that I took were somewhere between $2 - $6 USD ($12 from the airport).
On my first day, I arrived much early than expected but Alexandra was able to let me drop my suitcase down while the room was being cleaned so I can hit the ground running on my trip. Communication was always fast and www.casadechiles.com had a very good high level breakdown of things that would interest someone visiting Mexico City for the first time. The apartment was clean and had everything that I needed from towels and water, to an iron and ironing board.
I won't hesitate to message Justyna and Marco the next time visit Mexico City.