The building is on the main street and it felt very safe and is walkable to Roma during the day. The apartment has a beautiful view, is relatively quiet, security is top-notch, and it has a functional kitchen. There is a very nice rooftop with a few different private areas to choose from.
There is a great little breakfast spot downstairs called Central 46 (get the pancakes, eggs, bacon, beans, coffee, and orange juice breakfast combo), there's a small pharmacy downstairs for basic needs, and an Oxxo a few blocks away.
At first, I was hesitant because I had read online that Doctores has a bad reputation, but I thoroughly enjoyed my stay here. I would absolutely stay here again. Fidias was an excellent host, quick to respond whenever I needed anything.
I personally wouldn't walk around the area at night time (after 6 pm-ish), but it was easy enough to get an uber from the main tourist areas for just a few dollars, and the building entrance area felt safe.