I stayed at Nando's loft for a few days after wrapping up a work week in Santa Fe, which is an office/business suburb of CDMX. I highly recommend Nando's place for people visiting Mexico City for business but who want to get a feel for the "real" Mexico City.
The loft's location in Polanco is ideal. It's a short walk to the museums and parks and also to the Lincoln Park area and its restaurants and shopping. Don't miss the Museum of Anthropology! The Zocalo and the historic district is a short uber ride.
Nando is super-responsive and provides lots of guidance on where to go, where to eat, and what to do. When I mentioned that my favorite restaurant (the seafood restaurant Contramar) looked all booked up during my stay, he pointed me to Contramar's new "sister" restaurant called Entremar. It was a block away! And just as good.