Senglea is an up and coming area. It is much quieter than Valletta (which is sometimes nice) but has some great restaurants within walking distance. Velletta is accessable by the nearby ferry so no problems there. If you book a room here make sure you specify one of the rooms overlooking the bay as the room we had was at the back of the house, a bit small and dark. Breakfast was cereal, crackers and juice but there is a good kitchen where you can store and prepare your own food if you need to. The access involves a lot of steps so if you have mobility issues this is not the place to go. The views from the front of the house and kitchen are stunning, overlooking the bay. We never actually met Carlo or Caroline so can't comment on the hosts, however they did respond well to messages.