Most importantly, this place is located in a comparatively QUIET part of the old town. If you stay somewhere further west, you'll be a little closer to restaurants and such, but be ready to hear a lot of singing and drunk people hooting all night. It's worth it to stay here, where it's further away from the commotion but still walkable to the commotion when YOU want it. It also is located very near the Santa Apololonia train station and the cruise ship terminal.
One negative is that the stairway here is extremely narrow and steep, so it's not good if you have limited mobility or if you have large luggage. This is common in the old buildings here. Also the streets are steep and cobblestone, so you should probably avoid the whole area if this describes you. If you are staying only a night or two, you may want to store your luggage at the Santa Apololonia train station (my bag was 6 euro for 24 hours) and just carry up essentials.
Marco was very nice and accommodating. I got in very early and he kindly let me drop off bags and check in early since there wasn't anyone before me.