The apartment is not directly accessible by car, but it's only a short (uphill) walk from the closest corner a car can reach. The streets were residential and small so did not show up on most tourist maps we used and without Google Maps it would have been difficult to get back from certain areas (and locals were mostly not familiar with the street) but we quickly (within 1-2 walks) figured out exactly how to get there from Rossio Square (main train station) and it was easy to get directions to there. The apartment was beautiful, well-furnished, and the kitchen was well-supplied. We were at first nervous there wouldn't be much to do at night within walking distance but it is a very close walk (10 minutes) to many restaurants and fado clubs on R Sao Tome. We had a great time and would definitely go back!