Ana and Antonio's place is beautifully decorated and the location is fantastic for guests who plan on focusing on the tourist attractions during the day, but you will need a taxi/uber to get to Barrio Alto and the night life in Lisbon. The location is incredibly safe and a close walk to the main avenues and streets filled with restaurants and shops.
If renting during the winter, be aware the apartment can be a little cold and has no heater system other than an electric heater.
Ana was very responsive and Silvia made herself incredibly available and helpful.