We stayed in Ana's apartment for a part of our honeymoon, and it was fantastic! She was there to help us get into the apartment, she had great recommendations about local restaurants, and even pointed us to the MAAT museum in Belém which was a highlight of our stay. There are great, affordable restaurants within a few blocks of the apartment, and it's walking distance to chiado, bairro alto, and even the alfama if you like walking (we did almost everything on foot from ana's, but cabs are affordable). It's also easy walking distance from the train that takes you to cascais and belém, which are worth the trip.
In all, the apartment is perfectly situated, and i have to say, i've never slept better than i did in the loft, it's quiet and high above the street. The balcony has a lovely view of the river below.
We would love to stay with Ana again and would recommend this spot to anyone headed to Lisbon.