Great location in a quiet but active area with a great host who answers to mails almost immediately and provides a lot of informations on this area.
We usually walk 10-15 minutes to Shinagawa station to save money but if money isn't a concern the place is less than 5 minutes walk to Shinbamba station on the line Keikyu (Keihin Kyuko), which is at 2 stations to Shinagawa, a major transit station to various others lines (including Shinkansen lines).