We visited Venice for our 30th wedding anniversary trip and we were certainly not disappointed. Luca's apartment is perfectly situated near the Madonna della Orto vaporetto stop (3 minute walk) but everything is perfectly walkable from this area too. On our first day in Venice the water transport staff were on strike, but a very meandering and scenic walk to the San Marco area only took 45 minutes and there was so much to see on the way which would have been missed if travelling by vaporetto.
The accommodation is extremely comfortable - a ground floor apartment with an enchanting garden. The bed was very comfortable and there was always plenty of hot water available. The kitchen is well equipped with everything you might need. Everything was sparkling clean. Marino, Luca's father, greeted us upon arrival and was charming and very helpful, answering all our questions (in English), recommending restaurants and places to visit. We were extremely grateful for his directions to the nearby Prix Quality supermarket - as we would never have found it without his help - it is down a narrow path with no signage! Luca and his family live in the same building, on the floor above, and were always on hand if help was needed.
We would definitely recommend staying in Luca's apartment to anyone planning to visit this beautiful city - and we certainly plan to return in two years time for the Biennale.