If you want an experience of what it would really be like to live in Venice, I can warmly recommend Alessia's studio. It's very cozy and charming - like Alessia herself.
For a telecommuter travelling alone, the studio has everything one needs, including fast wifi connection. The area, Dorsoduro, is not along the main tourist routes and therefore offers a more local atmosphere than e.g. San Marco district. There are many nice restaurants and a short walk everywhere.
To sum up, there are plenty of hotels in Venice for those looking for luxury, but if you want a real Venetian adventure, Alessia's place is for you.