Certainly the best location in Venice! Here are a few notes.
Pros: Best location you can find if coming in by train (5 min walk from station Santa Maria), very kind, responsive and accommodating hosts, elevator is a big plus when you have heavy bags.
Cons: Bed is a bit uncomfortable, the bell from the church next door woke us up in the morning, mosquitoes (don’t open the windows), and the building is a little sketchy.
Overall, given the great location, host and value, I would recommend this place.