We (a group of 8) had a wonderful stay at Manuela. The house is very, very spacious and has everything you need. Also the beauty of the property stunned us.
The tram station is really close by (just the streed behind the house) and it takes about 20min to reach Venice, which was very doable and the tickets are quite cheap. A supermarket and bakery are also just around the corner.
Manuela and Alessandra have been great hosts to us. We were able to check in a bit later (due to a late flight) and they helped us to get around Mestre and Venice. Also, they are just very kind people :)