Irene's place is perfectly situated for you to explore the Rialto area of Venice. It is just minutes (seriously--3 mins to Rialto, 6 mins to San Marco) from major sites on a quiet side street. Bonus: a lovely canal view where you can sit and sip your morning coffee and watch the boats go by.
My family stayed with Irene for several nights--were met upon arrival and shown the apartment and given thorough instructions about the amenities and trash pick-up, etc. Irene was prompt in her responses with any concerns/questions and offered helpful suggestions for our stay. There was also a guestbook for additional suggestions.
Her apartment has been completed renovated, so guests will enjoy the spotless and updated interior and the lift (no lugging bags up the 4 flights of stairs!) was a big bonus as well. Wifi was fast, great TV if you want to stay in, everything you need if you want to self-cater--everything worked perfectly.
Overall, I couldn't recommend her place more.