This was a really great location. The Dorsoduro is less touristy, but there is plenty of great shopping, eating and drinking there. In fact one of my guides mentioned Campo St Margarita as a top place for foodies. The apartment itself is down a quiet street that ends at the water with a gate that locks in the evening, so very quiet and safe.
There are many top sites to visit nearby, including Ca Rezzonico and Scuola Grande di San Rocco, which is entirely covered with paintings by Tintoretto. You could never leave the neighborhood and have a great time (although of course, you wouldn't).
The apartment had everything I needed and was very nice. A good, big shower and plenty of hot water. A cute little kitchen. The only reason I took off one star was the mattress on the couch was thin and hard. Others haven't minded it, but it made my back hurt.
The apt is not far from the train station or bus terminal. Use your phone, if it works, instead of relying on the written directions from google maps.
If you don't mind the hard bed, this is a perfect spot from which to enjoy Venice.