Having seen tourists dragging luggage thru crowded cobblestone streets in Venice, I was glad I stayed in Maestre, just 15-20 minutes away by bus from Venice. Giuseppina and her husband were really warm friendly people and what Airbnb at its best is all about. She works in the hotel business and in her youth traveled to China and Japan so she understands what travelers need and provides it. My room was ultra clean, had a comfortable single bed, a FAN, and a small fridge which I used a lot. There are no kitchen privileges, but she served me coffee nearly every day. And she washed clothes at a very reasonable price.
And should you stay at her place, do engage her in conversation as she is a very smart and engaging woman. She is originally from Sardinia and her husband is from Cuba. My Spanish is very good (much better than my Italian) so that became our language of choice and had several interesting conversations. She is a warm and generous person and one of the nicest that I have met in Italy, so that is saying something.
On the practical side, it is a bit of a walk from the train station to her place the first time but very doable. After that it is five short blocks (not like we have in Washington DC) to the #2 bus to Venice and before the stop where the tourists pile on so you have a good chance for a seat. And when you leave for good, this #2 stops at the train station.
Would I stay with Giuseppina again?
Definitely. Top marks in all categories.