Diana's place is unique, it's not my first time in Venice but now that I've been there, I wouldn't want to stay anywhere else.
You can take a Vaporetto right at the train station and in 10' be at Fundamente Nove, 4 blocks away from the house. From there, you can take boats to Murano or Burano (the latter I can recommend).
The photos make no justice of the place, it's spotless, tastefully decorated, and filled with useful features, but the price goes for the window's view from the living room. If you go, you'll know what I'm talking about. 5 mts from the door there's a great little restaurant with coffee and aperitivos. Do yourself a favor and lose yourself on the narrow alleys and passages around the place, you can easily walk to Rialto or San Marco but you'll fall in love with the silence and beauty of the neighborhood, away from tourists.