The apartment is very well-located: you're not pushing through hoardes of tourists just to get out the door, as it seems you might feel were you to stay, say, in San Marco. It's also a short walk from Santa Lucia train station, should you wish to take a day trip out of Venice - but not so close that you feel like you live in the shadow of a transit hub.
Everything works as advertised, and is comfortable. You will be able to hear every step someone takes in the apartment above you, and I assume that anyone living below you will likewise be able to hear you walk around, but I, for one, am used to that in general, and aside from this minor issue, the space is pretty quiet and the neighbors are polite and welcoming. The internet is fast and good. We had a minor issue with the washing machine needing to be cleaned, as it had gotten a bit mildewy from disuse...but Michele was kind enough to arrange for someone to drop in, on Christmas no less, to take care of it, so no grudges there.