If you are looking to stay out of the major tourist-y action of Venice, stay here. It is a beautiful walk (~30 min slow pace) from San Marco, and ~10 min to Via Giuseppe Garibaldi. You also have the public gardens (even less visited by tourists) next door. Additionally, you are located a short short walk from the vaporetti, making it easy to go anywhere in Venice, Lido, or Murano directly from the terminal. It is really quite different.
Communication with the host was clear; we received a couple recommendations as well. The place itself was very clean -- we could tell that the sheets and towels etc. were fresh. It is definitely a solid value!
I would recommend staying off the beaten path and staying here instead :)