We travelled here at the beginning of March and thankfully managed to avoid the crowds. The accommodation is spotless and has everything you'd need (all fittings are modern). Our host met us at the Sant'Angelo water bus stop and it's literally a short stroll (5mins max) to the apartment.
Venice is very intimate and tightly packed. Hence, we were never far from any of the sights whilst still being in a very quiet part of the town. A good balance. Another advantage is that the "bars" (for your coffee, breakfast, gelato) are much more reasonably priced than if you were to eat near to say, Realto bridge.).
Highly recommended.