i would highly recommend staying at alessandra's flat whether it's your first or millionth time visiting venice. it's in a quieter, more residential location and conveniently located about a 15 min walk from the train station - which is ideal if you have luggage.
her flat is clean, spacious, and has great natural light. i loved the small balcony connected to the bedroom as well. alessandra was available when necessary and check-in/out was a smooth process.
the restaurants and bars on misericordia are super fun if you want a more local, less tourist-y experience.
would definitely stay again!