This is a beautifully restored house in Canerregio, a residential area that's quiet but still with good wine bars and some really nice restaurants. Venice is easy to get round on foot and although north of the centre its ideal for water bus stops and San Marco is only 30 minutes walk - and it's a great walk!
It was February when we were there so obviously quieter anyway but I imagine it would be a nice retreat from the Summer crowds at the end of the day. Giusy is a lovely host, knowledgeable and very helpful and lives next door so always on hand. Highly recommended.