Location: Awesome. Non-touristy but close to everything.
Do: Check out Stefania's tips for tapas/aperitivi-spots. Go jogging the narrow streets in the morning and kayaking in the canals in the afternoon. San Marco&Doges Palace afterhours.
Don't: put all of your hopes in the WiFi to work inside the apartment.
Best restaurants for us: Rossopomodoro (chill) and Da Fiore (fine dining)
Also, Stefania is super-nice and thoughtful. Highly recommend this room.