This is a great place to stay. It is a short, walkable distance from the airport shuttles and the Santa Lucia train station. The rooms are clean and modern, and the shared mini-kitchen (it is more of a Bnb style location more than a hotel) has a microwave, and a coffee maker with plenty of coffee pods. The location near the historic Venice Ghetto is quiet and pleasant, and very accessible; you can walk anywhere on the island if you are comfortable walking for 30 minutes or less, and moreover Le Guglie LT is also immediately next to a Vaporetto stop (Venice’s charming water bus and public transit).
Paolo is a responsive and helpful host who I recommend highly, and the value of the apartment is hard to beat. I would absolutely stay here again if I get the chance!