This location is perfect if you have a short 2-3 days stay in Venice and don’t care for the water taxi. It is about a 5 minute walk from the train station (crossing only two bridges) and roughly a 10 minute walk from Piazzale Roma(bus from airport, crossing three small bridges).
We were a group of 8 including my wife who is pregnant at 7 months, two 18 month old babies and one 4 years old and we had no trouble making the trip on our own.
Irene is a great host. Good communication and gave us a really good orientation.