I have traveled to Venice many times and stayed at the top hotels. I have rented recently through air b/b a penthouse in Rome. I wanted a private setting, where I might cook and have a phenomenal view. The apartment is located directly on the Grand Canal and opposite the famous Ca'D'Oro with a small docking area under the window. It is a million dollar view as you stand at the large bank of windows and take in the canal's animation.
I consider this a great spot because of the close proximity to the Rialto markets and the vaporetto stops. You are steps from fury of activity yet the feeling is tranquil. The apartment is fine for two people although it has beds for four or five. It is sparsely furnished utilizing the two main rooms for beds, a large bathroom with shower only and a functional kitchen. I would have preferred a sitting room rather than beds in each main room. The check in/out was seamless.