Francesca's place is a very reasonable and enjoyable walk from the train station, and a slightly longer walk to the city center. The ladder is admittedly daunting at first, but it's shown right there in the listing photos, and for anyone visiting I would recommend you bring luggage no larger than a backpack or duffel bag to make transitioning from the living room to the attic easier (and frankly it makes navigating all of Venice much easier). There are a lot of great local places to eat nearby, the neighborhood is quiet, and you can fall asleep and wake up looking at the skylight above. I stayed for a few days in March and the temperature in the attic was perfect. Francesca is very kind and patient, and her place was an excellent spot for my introduction to Venice.
FOR THE DIRECTIONALLY CHALLENGED (like me): make sure you use the Google Link Francesca gives you directly, versus trying to search for the address in Google Maps, as it kept taking me to another location in a different neighborhood.