The room is centrally located. It is about 15 min walk from the Santa Lucia train station (don't accept help from strangers to carry your luggage!!!!!) and also 15 min to Piazza San Marco via either Rialto or dell'Academia bridges. Vaporetto is not really needed. My wife and I didn't use it at all. It is advisable to use a map in Venice, but there are plenty of indications (per Rialto, alla accademia, Piazzale Roma, alla ferrovia) and the room is in front of Ca' Foscari University. Finding places will not be so difficult. On top of the good location, the room is in a quiet area. So, if you want to relax at night after a long walking day, you are likely to find it. Check-in time will be very dependable on Jacopo's availability. In my case, we agreed to leave the bags in the apartment before check-in, but due to train delay (quite common) and Jacopo's availabilty, it was not possible. Jacopo offered me options and in the end it worked. But it would probably had been better to leave the bags in the station (storage) before check-in. Bedroom and bathroom were clean and decent size. Despite some communication issues, Jacopo was very friendly and pro-active. We actually didn't have much chance to interact beyond check-in time.