Staying at Alberta and Raffaella's place in the Dorsoduro neighborhood was a wonderful choice. We felt like locals the whole week - it's great to see how real Venetians live and play. If you bypass the tourist traps, relax in a neighborhood joint, get a coffee or a Spritz with Cicchetti, you can observe the real life of Venice. It's the perfect balance of being in Venice but just slightly off the beaten path to avoid the hordes of tourists that invade the city.
There are many amazing restaurants nearby that serve fantastic Venetian cuisine (Spaghetti al Nero di Seppia, Seafood Risotto, Fegato alla veneziana and Cicchetti). There is also great transit access. Not to mention the museums and churches you'll want to see are all very near.
The apartment is luxurious, comfortable (A/C is a big plus!) and the perfect size with all the amenities to make it feel like home. The decor is wonderful mix of eclectic design and new furnishings.