Located in an iconic bldg built in 1640, Marinaressa is a very comfortable apartment for a single person or couple. Yes, it's located a bit outside the usual tourist routes, they can be easily reached by vaporetto, if far. Piazza S. Marco is a 15 minute walk from there. If your aim is the Biennale, this is an ideal place to stay since it's located no more than 7 minutes from either major venue. I loved this place because of its location - far from what I call "tourist hell" and close to the heart of the living Venice. Via Garibaldi - the widest street in Venice and its only "via" is at the center of a vibrant local area with all the amenities one would need: a supermarket, bakery, restaurants (including vege/vegan), bars as well as families with kids. I loved being down there. I look forward to my next stay at Marinaressa. Having stayed mainly in S. Polo and S. Croce during my past visits going back 20 years (and make no mistake - those are wonderful sestiere close to the main cultural offerings of Venice), I found the relatively lack of tourists in that part of Castello refreshing.