Sebastiano's flat is in a great location. It is close to a big square very animated at night, but the flat itself is in a quiet place, with view on a canal. So very typically Venetian ! It is about 10 minutes by foot from Piazzale Roma (where the buses from the airport arrive), about the same distance from the railway station and less than 10 minutes to the Accademia. From there, you can go anywhere by foot (San Marco, Rialto, Zattere, Peggy Guggenheim museum, etc.). What is great is that it is central and at the same time quite local in the atmosphere. The square nearby is full of students (the university is nearby) and full of very local life.
The flat is very Venetian too, with painted ceilings and even a Murano lamp over your bed. It has three good-sized rooms (kitchen, lounge and bedroom) with all amenities necessary.
Sebastiano is a great host : communication with him is easy and he is a true Venetian as well. So what's best to discover, explore (and get lost) in this unique town !