Centrally located apartment in the middle of a warren of medieval lanes. That's charming, but consider dragging your stuff to and from the place and if you're not traveling super-light, the effort to lift and carry on lots of bridges, narrow cobblestone lanes and hordes of tourists can be quite stressful.
Beyond navigating baggage, steps and people, the apartment itself is quiet, clean and in the middle of a bustling part of town (during the day). Having a washing machine was also great. Be sure to get instructions and actually try each of the 3 keys to the doors/gates as some of them can be tricky.