A nice apartment close to the Arsenal (Biennale sites) and the city's key building, easy to reach by a direct boat (Alilaguna Blue Line) from the Airport to Arsenal station, no need for local vaporetto pass as you can walk to the apartment and any major places. Comfortable apartment for 2 or 3 people, well equipped kitchen, cleanliness--and all that in a typical Venice neighbourhood. Francesca and Cristian are extremely nice, helpful and responsive people, one of them will meet you at the Arsenal station in person.
There are two friendly coffee shops in the vicinity, plus a small grocery store where you find the best Italian food at reasonable prices.
You need to check out the weather and sea level (especially in November and December) before your trip as sea my be high in autumn/winter for short periods, and you will need good rubber boots on certain days.