Manuela's place is located in Giudecca, a smaller island below Venice island. If arriving by train like we did, there are a couple of public boats you can take from St. Lucia station, and they can take up to half an hour to get to Giudecca depending on the time of day. I recommend buying a multiple day-pass for the boats around Venice if that's how you plan on traveling. Manuela's colleague Valeria actually met us at the station and helped us buy the passes as well as came with us on the boat to show us how to get to the apartment.
Giudecca was a very quiet neighborhood, mostly residential, but there is a grocery store and multiple restaurants. Manuela's apartment is located closely to the boat station (Redentore) as well as the bridge that leads to more restaurants. It is a 10-15 boat ride to San Marco.
The apartment was very clean and very luxurious! We had everything we needed. Thank you Manuela!