We had a wonderful stay at Massimo's apartment. It is walking distance to many important sights, though still apart from the crowds. Massimo is a gracious host with lots of information and pamphlets on Venice. He sent us detailed maps and information beforehand on how to find the apartment, which made it really easy for us. Staying here in Cannareggio enhanced our enjoyable Venice experience.
A general Venice tip - bring mosquito repellent ;-)