Very nice, stylish villa, and great communication to help me find my way there. It's one island away from Central Venice, so you'll need to take a boat to get to the main island, but it's only about 20 or 30 minutes to the main tourist areas. Once on Lido, you can take a bus to get a little closer to the villa, so you only have about a 5-minute walk.
I strongly suggest that you buy a pass for the boats, for however many days you will be there. Much cheaper than buying individual tickets, plus you can use it as often as you like to move around the main areas of Venice. The pass also covers the bus system on Lido.