The Santa Margherita Guesthouse was really wonderful. Given my schedule and room availability, I had to switch rooms but Maria was very accommodating and it was quite easy. The kitchen is well equipped with everything you need and there was plenty of breads, yogurt, etc for a good breakfast. The rooms (I stayed in a single, then a double) are very spacious and there are nice touches like coffee/tea/biscuits in the room, a guide book, maps, etc. The guesthouse is close to a university campus, so a lot of the nearby nightlife is full of students (this could be good or bad, depending on your age). That said, right across the closest bridge there is a world-class Jazz club that is phenomenal (but you need reservations, it is like a concert). The rooms are quiet though - except perhaps for occasional seagulls. The Rialto bridge area is still accessible by foot, but I'm glad I chose this spot because I think it is much too busy there.