We planned our Venice trip by staying at Venice-Mestre, and going into Venice by train every day. I am so glad we did after arriving into Venice and seeing the hordes of people with large luggage on ferries and the narrow streets. If you don't mind a 10 minute train ride every morning to get into Venice to see the sights, then the location of the apartment make it the possible.
The host met us for the check-in and explain how every works. We loved how clean the unit was and how close it was to the train station. The AC was working great, and we had no other issues.