Our stay with Eugenio was marvelous. The room is large with a large private bathroom. It is very quiet and autonomous from Eugenio's apartment. Eugenio is available for your needs, but I doubt you'll have any. The room has plenty of storage and a hot water pot is on a table for coffee or tea in the morning. A nice touch.
The walk is only 10 minutes from s. Lucia station. I believe it is perfectly situated in a "quieter" part of the island. A lot of bars, shops and restaurants close. About a 20 minute walk to St. Mark's.
I highly recommend this room and it's desirable location. If I return to Venezia I will look first to Eugenio.