If the crowds in central Venice will get you down, head to Guidecca! My husband and I stayed here in early October and felt very at home. The canal view room comes with the sounds and sounds being canal-side has to offer and the bed was seriously comfortable. As for our hostess, Francesca is very friendly and helpful. Besides the good recommendations, she also made restaurant reservations for us one night, which was immensely helpful. One hint is that if you are taking the vaporetto service directly from the airport, you will need have someone at the HIlton hotel lead you through the hotel to the street on the backside, where the B&B lies. There is also a walkway along the east side of the building, but it is sometimes closed.