Absolutely perfect location if you want to be walking distance to all the sights, but still feel like you are in a Venetian neighborhood. The apartment was very clean and comfortable. The AC was a nice bonus. Our favorite part of the apartment were the two balconies, one of which we ate breakfast every morning. We highly recommend this apartment!
One more note.... After taking the Alilaguna from the airport, you will be instructed to take a Vaporetto one stop across the grand canal. It's €7.50 pp for this. We chose to cross the Realto bridge and walk it in 6 min. (With backpacks) instead. It might be difficult with rolling suitcases, your choice... But definitely get a multi day Vaporetto pass if you take it!