If you want amazing views of the Grand Canal -- right across from the Guggenheim, this place can't be beaten! Note this is up 4 flights of stairs, so not for the faint-hearted or those who travel with too much luggage.
Also, some better instructions left in the house for issues like restarting the water heater would have been appreciated. The host is very friendly and made great arrangements for Water Taxis, which worked perfectly door to door to train station (about 10 minutes).