As a group of 4 adults, we found the apartment to be well designed and spacious, with a good-sized and well-equipped kitchen (which had an espresso maker!). I think the living room is quite large by Venetian standards.
As noted elsewhere, there are a number of stairs to get to the apartment, but there is a small elevator that was handy. (You walk down half a flight of stairs from the elevator to get to the apartment.) The apartment is located in a very quiet location, and is within walking distance to many sites (e.g., Rialto Bridge, Doge’s Palace). There are a few grocery stores not too far away, including a Despar supermarket that we liked.
Matilde is very pleasant, and she was very helpful in arranging transportation. I would recommend this location.