Roberta's place is centrally located for everything in Venice. All the site- seeing and shopping is right outside their door. Even though their place is right in the middle of all the action it's extremely quiet when you need to rest. Also Paolo has great recommendations for eats and tips on everything there is in Venice. Also like to add their accommodations and amenities are 5 star hotel like. Best Airbnb in Venice.
Bonus - Paolo is a pretty funny guy.