The apartment is beautiful and has everything you will need for your stay. Alessio and Katia have thought of everything, and were fantastic hosts. The apartment is tucked away in a quiet neighborhood just a 2 min walk to the Vaporetto. Your are near a supermarket, a pharmacy, many restaurants and the Hilton Rooftop bar. The beds are very confortable, the air conditioning worked great (one of the days was very hot).
Guidecca is a great option of where to stay. You are away from the crowds of Venice, but still a 7 min Vaporetto ride away. You will experience a little more of the local life. Buy a multi day Vaporetto pass and you can move around between Venice and the other islands very easily. The Vaporetto runs 24 hours a day, although all nightlife in Venice ends around 1:30-2am.... if you know where to go!!
On my next trip to Venice will definitely stay here again. Thanks Alessio and Katia for all the recommendations.