Annamaria's studio lies in a beautiful, calm neighborhood, still within walking distance from San Marco square, and a nearby boat stop (also very convenient). I stayed with my mum in the studio and that was ideal. I think the studio is too small for 5 adults, also 4 adults might be tricky.
The check-in with keybox and communication with Annamaria went very smooth, I can recommend this place, we would come here again!