Florence or Firenze is an old town with no place for cars. You can walk from one end of the old town to another in about 20 minutes. We had allocated about 2.5 days to this place and it was possible to cover everything in detail because we stayed at Antonella's place.
We had the pleasure of welcomed by both Antonella and Paola. Paola gave us a tour of the place and spent plenty of time pointing out things to do on the map. They both are very warm and friendly, and it's a joy to interact with them. They allowed us to check in early and made sure that our stay would be comfortable. Their welcome guide was detailed and very useful.
I highly recommend that you get the Firenze card online, then download the app and activate Museo Duomo on the app. This will generate a QR code and a number. You can then plug in into Duomo's website to book your time if you want to climb the Duomo. Entrance to the Duomo itself is free. Firenze card saved us a lot of time and money. It's available 72 hours from the first use.
With Antonella's location, you can come back to your apartment any time for some rest or nap in the middle of the day. Everything is next door - really. It's a great location in Florence. I recommend eating a meal at Za Za and a panini at Panini Toscani.
Enjoy Florence. Book with Antonella - she is a perfect host. One caveat - there is no elevator - so you will have to haul the bags up about two floors. Was not a problem for us. In exchange, you will get a fab location and make most of your time here.