*Extremely* centrally located - my room literally had a view of the bell tower of the Duomo. The room has everything you need when you spend all day exploring Florence and just sleep in it, which is exactly what I wanted - but don't expect a room you'll want to spend time in for other things than that.
Being this central of course also means noise from the street below, and being woken up at 7:45 by the bells ringing every morning. That's part and parcel of being that central, so not unexpected, but do consider bringing earplugs if you are bothered by noise when sleeping.