You could not ask for a more central (and huge!) flat than Isa's. Just far enough across the bridge to avoid the tourist traps and close enough to reach the Uffizi in 5 minutes walk along the beautiful river.
Isa was a lovely hostess, very friendly and full and fantastic tips on where to go and what to do (and most importantly the best places to eat).
The apartment itself is very big, with huge comfortable beds and incredibly high ceilings. It has a very traditional feel to it and a marble staircase to boot! We'll be back as soon as we can.