Vanna + Massimo were simply lovely! Near-instant communication, perfect location, and a beautiful attic-inspired room. Couldn't have asked for more. They live within a mile from the center of everything, Duomo, Uffizi, Galleria, Ponte Vecchio, etc. Campo Di Marte Stazione is about a 10 min walk (15-20 min with heavy luggage). Great tips and recommendations given, including a mini bottle of champagne upon arrival.
Minutes away from 2 of my favorite cafes: Caffè Pasticceria Serafini (AMAZING for dinner aperitivo, including a non-alcoholic option), Le Murate Caffè Letterario which is situated in what used to be an old penitentiary with wonderful coffee and also amazing aperitivo (for lunch too!).
If you head in the direction of the train station, you'll find the Nelson Mandela Complex which has a track and a gym for anyone trying to maintain their fitness regimen. There's is also a really cool daily outdoor market on the back end of the complex with produce stands, formaggio stands and even a Tripperia...yum :)
All in all, they are close enough to everything you want to see but distanced enough to not be inundated by all its accompanying tourists. Don't wait, just book.