I had an absolutely lovely time staying with Alessandro and Fiamma. Their home is part of a converted abbey with hundreds of years of history, and I felt immersed in it every day between the beautiful old wood ceiling beams, the tiled floors, and the traditional barrel vaulting in the kitchen and bathroom. In some places, you can even see little glimpses of the former frescoes! It was all on the ground floor so as someone who walks with a cane this was very convenient; there is only a short step to get inside the front door and also a short step to get into the shower, but this was no trouble at all.
The place is directly across the street from a bus stop where you can catch the bus straight into the city centre with only about a 15 minute ride to San Marco and 20 minutes to Santa Maria Novella station. Closer to the place is a lovely little neighbourhood called Le Cure with an open air market and many cute boutiques, where I spent a nice Sunday afternoon shopping. My one warning is that you are a light sleeper (I'm not), it may be a little difficult for you as the windows open directly onto the street, but the hosts have graciously provided ear plugs for those easily awoken by traffic.
As hosts, Alessandro and Fiamma are extremely gracious and welcoming and have provided the rooms with every possible thing you could need. They are extremely helpful and can easily give advice on any questions you may have about the area or facilities, and they have furnished the house with bright, vivid decor that makes the rooms glow with warmth. The back patio beneath the wisteria is dreamy and I enjoyed some much needed relaxation there with a beer and a good book. I absolutely recommend staying there and hope to stay with them again one day soon!