You can't beat the location! You are literally steps away from almost everything, including Piazza dell Signorai, Uffizi Gallery, the Duomo & Ponte Vecchio Bridge, just to name a few.
Diana, the host, was so accommodating. She worked with our travel schedule and had lots of restaurant recommendations as well. We would highly recommend Birreria Centrale (around the corner), Trattoria 4 Leoni (try the cheesecake) and INO sandwiches (near Ponte Vecchio).
As far as the B&B itself, our room had great charm but was extremely noisy at night because the drunk tourists use the alley below as a cut through to some of the nearby bars. Someone else suggested earplugs so I'm glad we had those. I would also suggest the "white noise" app on your smartphone.
We had a room with a detached bathroom down the hall, which wasn't super ideal but luckily, it wasn't a problem. And finally, while it didn't bother us, I feel it's only fair to mention, breakfast in the morning is actually served at a cafe just below, not in the apartment with the other guests.