We (1 adult and 3 teenagers) stayed at Margherita and Michael's apartment for 6 nights. The location of the apartment is perfect as it is close to the Duomo, the museums and other main touristic points of interest. The neighborhood is safe at all hours. We walked to the train station Santa Maria Novella at 6:30am to go to Pisa and we felt perfectly safe the whole way. You can take a bus to the train station if we do not like walking as there is a bus stop a few streets over.
The apartment is modern and has everything you need to feel at home. We loved its decoration and authenticity. The beds are super comfortable and the shower is very relaxing after a long day of walking around. There are good bakeries in the area and supermarkets if you want to cook meals. If not, then there are many amazing restaurants nearby. We loved our stay in Firenze and we will definitely come back!