I liked having some open space to move around in. I enjoyed all of the windows and getting to watch a parade down in the street one morning. The beam over the bed makes the upstairs space awkward, especially if you're tall, but it's fantastic to wake up and put your feet on it and stretch!
Everything you could want is close by: the Arno river, the Uffizi, the statue of David, Duomo, the Galileo museum, Ponte Vecchio, the Central Market, the train station, restaurants (of all kinds), groceries, pasteries, gelato, laudromat, even the U. S. Embasy.