Absolutely great location, 10 minute walk from all the great sights and Santo Spirito is the “ non touristy” Florence . Beautiful market every few days and Sunday’s market is to behold.
Local craftsmen and artisans occupy most of the neighborhood and it’s a joy to watch them at work. I would bring earplugs as weekends tend to have college students walking down the street at night and they’re not the quietest. No fault of the host.