We just spent one night at Donatella's place but the location directly in the center of Florence made it ideal for us to get to know the heart of the city in a short time. Most of the tourist attractions can be reached within a short walk. I guess best way to travel to Donatella's place is by public transport. We came with our car which was ok but I think it can be difficult (and expensive) to find a parking due to the very central location.
Donatella was very nice and friendly and her apartment is really beautiful and decorated with style. Her son was very helpful in guiding us to the place and helping with parking etc.