I would think Luca's apartment has the best location in town. It is right next to Cathedral of Santa Maria del Fiore, which is the heart of Florence. When i arrived, Luca told me the apt i booked has some plumbing issue that day and arranged me to another apt in the same building. The other apt was actually larger than what i had booked and they both has access to the roof top of the building, where the cathedral and the tower are just standing right in front of you. Early morning or late afternoon, you can grab a beer sitting there enjoying the magnificent view of cathedral and city. Don't forget to take tripod with you, you can take the best pictures as many as you want without others running into it.