It was our first stay ever in an Airbnb. We were very happy with everything. The check-in was easy the place was immaculate. We had a little trouble maneuvering the bus lines to get downtown so we used taxi. We found the Coop for groceries. Maybe a 15 minute walk away.
The apt was a very quiet location so it was nice to get away from the crowds and just chill :-). If you want to be more in the mix of things without taking a taxi/ figuring out the bus line or a bit of a walk, I would suggest just staying closer to the center. Not our style however.