The location of this place is very central, giving us quick access to major monuments (Cathedral of Santa Maria just north, the Uffizi across the street, and Ponte Vecchio steps away). The furthest that we had to walk was to the Piazzale Michelangelo, and that was an enjoyable walk. Soraya also provided some good suggestions to dinner venues and nightcaps. Overall, it was a great stay!
The only drawback of staying in a central location is what you would expect - lots of shops and restaurants drew crowds during late hours and the noise was a bit much some evenings. Just something to keep in mind if staying for several days.