Donatella and her daughter were great hosts, and our stay there was wonderful.

(1) Location: Her home is a quick taxi ride from the train station or a 10-15 minute walk. However, once you arrive, everything else you want to do is extremely close. The Duomo is literally up the street. The Academy, where the statute of David is, is close as well. Extremely safe neighborhood.
(2) Donatella is very responsive, and both she and her daughter were kind and caring folks!

Overall--a great experience and definitely would go back if we could.