Raffaella's Airb&b is terrific. Not only is the location perfect for seeing Brunelleschi's Dome, it's also walking distance to the Great Synagogue of Florence. Location is everything, and there are lots of shops, restaurants, and amazing sights all close to Borgo Pinti. There's even a jazz club around the corner!
If you are lucky enough to stay there, make sure you visit the courtyard. What a delightful place to stay! And I hope to be lucky enough to come back for a second visit!