My father and I really enjoyed Anna e Isabella's home. They were charming and very friendly. They greeted us upon arrival and arranged for our taxi to the train station upon our departure.
The neighborhood is nice, quiet and less touristy. Piazza Santo Spirito was a quaint square with evening music, bars and restaurants.
Their home is nestled in a courtyard garden and a quiet, restful retreat from crowded Florence. Their family has owned the property for over forty years, so they definitely have local expertise to offer. The history of the home is quite interesting!
They provided great local recommendations for neighborhood restaurants (we enjoyed Casalinga, Gusta Pizza, 4 Leoni, Gelateria La Carraia) and were quick to respond to general questions about Tuscany. If you're interested in being close to Pitti Palace or Boboli gardens, it's the perfect spot. Regardless, the location is very central, with the main road leading right to Ponte Vecchio.
Grazie mille Anna e Isabella!