We had a nice and uncomplicated stay in our room in Florence.
The tram is just infront the house and 10 min away from the Duomo. San Niccolò etc. was a bit further out, but still okay to reach (~30 min).
It’s was more of a hostel stay than the usual private room - airbnb experience, we were expecting. Overall I would recommend to go Firenze offseason if possible, because the city is full with tourists in the Summer!