Yes you will need to climb a few flights of stairs, but of all of our stays at Airbnbs in Italy, Lisa's was the cleanest, and had the best amenities. Tons of little touches here and there in the room and bathroom - we had everything we needed. The view of the Duomo and Campanile was amazing - and we were very close to the train station. Lisa let us borrow a map which was incredibly helpful as we navigated Florence during our stay. We would definitely recommend!