I recently travelled around Sicily with 4 friends and we really enjoyed our stay in Ortigia. The apartment is stylish and comfortable, in a great location right in the heart of Ortigia and surrounded by shops, restaurants & bars - but you can also easily walk to the mainland for historic Neapolis, and the station is a simlilar distance.
Fabrizio & Daniele are very friendly and communications were easy. If I was visiting Syracuse/Ortigia again I would not hesitate to book this B&B.