Domus 1333 is a gem -- a beautiful modern apartment on three levels crafted in the middle of a 13th-century building in Ortygia, just steps from Siracusa's beautiful, historic duomo. The location couldn't be better for exploring Ortygia's fascinating little streets and corners, or for eating very well: all kinds of options for dining, shopping and sightseeing are just a short walk away. (There was even a cozy little osteria in the courtyard right outside our door.) We used this lovely spot as our vantage point for exploring Siracusa and also a few nearby sights of southeastern Sicily -- the charming town of Palazzolo Acreide, the eerie necropolis at Pantalica and the amazing mosaics of the 2nd-c. Roman Villa di Casala at Piazza Armerina, all were easy half-day trips from Siracusa. We'd stay again, and recommend it highly.