The apartment is ideally located (one street away from the seafront) and everything can be done in walking distance. The apartment is on the first floor which implies that you hear sometimes people which are walking by. So if you prefer to have a "very" quite accomodation, I recommend you to choose another Airbnb. Ortygia can't be entered by car during the week but you can park in a parking garage which is 5 min away from the apartment.
Thank you Thomas for your recommendations and for making our stay unforgettable!