This place was the best of both worlds! Close to everything in the city but quiet and cozy at night. We were able to walk to Duomo and back walking along the river and through the city. At first we were abit worried about the area but its actually pretty tame for a city center, even at night. Our host was really helpful in getting us in the gate and situated. We had a few hick-ups with the internet but it was sorted out the next day.
The loft itself is well designed, lots of eclectic decoration, the perfect flavor for Milan! Its a big open space but still feels cozy and relaxing. A huge bonus was having the back enclosed patio.
One note: If you come during mosquito season bring an arsenal of repellant! The host had some stuff but also have some spray on hand for walking around.