Brera is a wonderful location - every must-see in Milan is within walking distance and transportation isn’t a problem too. The area is super cool - with restaurants, shops, piazzas all over. You'll definitely enjoy your stay.
Dimitri and Marcelo are Brera's wonderful hosts. They took me around the city on my first day -- what a nice touch! They will give recommendations and will help you out with your itinerary to ensure your trip is great. They are responsive and will make you feel at home! I was a solo traveller and that helped!