We had a great stay at Barbara's little apartment in Milan. It's away from the city center, in an authentic non-touristy neighborhood, but has excellent transportation connections. The Affori train and metro stations are just a few blocks away. The Metro yellow line will take you to most of the tourist sites in a few minutes. The station has an elevator for handipcap accessibility. Next to the Metro station, you can use the train station to come from Malpensa airport (with one simple train change), or (as we did) to go to Como (again with one train change). Theoresre are grocery stores nearby, and plenty of moderaterly-priced restaurant options.
The apartment was spottlessly clean and well supplied with everything you need. Barbara was a very kind and attentive host, and was always reachable if we needed anything. We'd definitely stay there again.