This a huge, comfortable Milan base in a fantastic neighborhood. There are lots of trending restaurants and everything is in walking distance. Directly across the street is a real bar/pub which is unusual in Italy. It is a high end place and a great spot to start or end your day. We walked to the Duomo, which is an easy and scenic 20 minutes but if you prefer public transportation the bus is direct and takes about 5 minutes.
This is definitely a safe neighborhood; there is a previous review in which a guy says that he was harassed by someone on a bike but that is reactionary. Yes, Milan is a city. Yes, like any city I suppose you can run into some less than ideal characters on occasion. But this is a totally vibrant area and it is not sketchy in any way. As in any city, be aware. But this area is lovely; full of families, parks and a fantastic variety of shops, restaurants, cafes and bars.