If you're thinking if the house doesn't look near to the city centre, don't worry, it has transport to everywhere, and I mean it:
Bus to Milano Centrale Station, subterranean train to Porta Garibaldi Station, tram direct to Duomo (it takes about 10 min) and also tram to other areas near city centre.
Massimiliamo was a great host, we didn't see each other too much, but he explained us everything. The double room was so comfy with a private bathroom. You also have the option of use the kitchen if you want.