Excellent location. If arriving at Milano Centralle then it's a quick few metro stops to Duomo and then a few minutes walk. Literally a few steps from the Piazza del Duomo and access to everything else you need (the close by pharmacy made it really convenient to take care of the COVID tests needed for the return flight).
The hosts were great at communicating and even helped walked me through when I felt like a total dunce when I didn't know how to operate the induction stove top.
All in all, a great spot for both folks who are passing through as well as setting up shop in Milan.