This was our first time in Milan. The apartment is literally around the corner from the Duomo (Milan Catherdra) - thirty feet from the building and look down the road and you will see the cathedral only a couple of hundred feet away.
The apartment is sizeable - we used the two bedrooms (1 double bed; one room with 2 single beds). But there is also a very large lounge with a fold down double bed should you need it. (Also a kitchen and a dinning area).
The apartment was clean. We found the washing machine really useful to wash clothes after staying in hotels elsewhere in Italy.
The host, Guia is extremely helpful. He went out of his way to assist and I would definitely recommend him and this apartment. He will send you instructions on how to get into the apartment - it is important to read and watch the instructions carefully - and when you enter the building note that the apartment has a 'Milan Retreats' sign on the door.
I doubt there are many hotels closer to the centre of Milan than this apartment and frankly accomodation of this size would cost a fortune in a 4 or 5 star hotel.
Strongly recommend and would definitely stay there again when we next visit Milan.