Cristiana met us at the apartment and showed us around, and gave us some great tips on where to eat and shop in the neighborhood. She is uber-responsive, and gave me perfect directions on how best to get to the apartment from Milano Centrale train station.
The apartment is in a great location, 5-10 minutes from multiple metro stations and 30 seconds from a tram line. It is an easy walk to Duomo and Navigli, and to tons of shops and restaurants.
The only con that I can think of is a bit of street noise at night. The apartment is close to a tram line, and the passing trams woke me up a few times.