When we booked this apartment, we didn't really know where it was. We were nicely surprised to find out that it's located right on one of the canals in Navigli. It's only about two blocks from a Metro station and was easy to reach from the Milan Centra station.
Even so, if you like to walk and the weather is good, it's a nice walk to the Duomo via the Castello Sforzesco (about 4 km one way). There's a dozen or more restaurants close to the apartment so if you're eating out, there's a lot from which to choose.
We had a great stay. Maybe, someday, we can do it again.