Staying at Anna & Ivano's was an absolute dream. It's walking distance from everywhere but has great access to buses and even trams. If you minimal luggage you can even walk from Termini there no problem!
The facilities were great for a short term stay and the area is quiet but has all the essentials. Most importantly the bed is amazing! Best bed I've slept on in all my travels. You'll definitely have a comfortable nights sleep. Would definitely be back!