We spent 5 beautiful days at Casa Anna. With 3 kids we had all the space and services we needed and really felt like home. The accomodation is perfect for 2 to 5 people. All the beds are very comfortable and sleeping in the bed-sofa in the living room was as comfortable as being in a bed room. The kitchen is very well equipped and large enough for up to 6 persons. Giampaolo and his family were extremely friendly and ready to help. They also provided us with maps and other useful info on the area. This is definitely a recommended place if you want to be close to the Vatican and surrounding areas but prefer to avoid hotels and other tourists traps. The area is central but quiet, you have 2 supermarkets very close open 7 days a week.
If you come by plane we recommend the car with driver service suggested by Giampaolo which is only 2 EU more expensive than regular taxi but does not require to search for anything (and the cars are probably more comfortable)