I had a great stay in Chiara's apartment. Although it seems to be remote from the city center, it really isn't. There are trains from Roma Termini to the Trastevere train station and you can also take the tram which brings you right to the city center. You can also take a train to San Pietro train station to visit the Vatican. You can even walk along the river and explore the city from there.
All in all I was happy there and would come back anytime!