Hello Vatican visitors,
I highly recommend to use Patrizia's beautiful, clean and comfort accommodation. It has everything what a traveller needs. Although its located in the busy city centre its really quiet, so you can sleep in peace.
And its very close to Vatican (10 minutes to walk or 4 stops by bus). Busses to Piazza Venezia and to Paola leaves every 5 or 10 minutes behind the house. Going to old town takes 15 minutes. Train station San Pietro is also very close. We used this link to go to Termini station.
An option for flexible check out was also very useful to us. We keep our luggage until the train leaving and used the day for exploring the city.
Thank you again Patrizia and Fabrizio!