Alessandro's flat is very nice and quiet big, the kitchen is amazing, you can make your own coffee and tee, and you also get a small breakfast which is very practical if you are in a hurry. We didn't have to use the public transportation. Termini is about 25 min, Colosseum 30 min and the Vatikan City is 20 min walk but you will surely stop by the nice shops on the way.
The communication with Alessandro was also perfect, he replied always in a few minutes, and as we arrived he took time for us and gave us some tips about the area, it was very kind of him.
We would definitely stay there again!