Stayed at Mauro & Federica's place with my family (a 65 year old mother and 38 year old brother). Somehow, this neighborhood offered something for everybody. I would strongly encourage you to consider Mauro & Federica's place if you're planning on staying in Trastevere. Walkable to the Vatican, the Colosseum, the Pantheon, all of it is less than a 30 minute walk through the beautiful streets of Rome.