I will stay at Little Italy again when I return to Rome. Rene is a fantastic host. He was extremely flexible and accommodating with my late arrival. On the last day, he offered to store my luggage while I explored Rome. What I enjoyed and appreciate most though, is his wealth of knowledge for Rome and his humor. As I traveled solo and stayed for only a short period, Rene made great recommendations to make the most of my trip.
As for the location, it's within walking distance to the colosseum as well as other attractions. Access to the metro is convenient and will take you directly to the Vatican City. The best way to the enjoy the city is walking.