Massimo was a very nice host. We arrived late at night and he offered to show us a place to nib something! We were very grateful for that, specially cause we had no idea where we were at all! The location is about 30min from the centre, and you have to walk from the house to trastevere for about 7min to get to the station, trams come very often and you can get off at piazza Venezia, and you pretty much have everything within a walk distance. Also trains depart from trastevere station to the Vatican and main airport. However, tram waseasier, at least for us! You can buy the tickets for the tram by a Bar outside the train station 7 euro is worth it if you plan on returning back to the house and back again.
When you arrive at the airport Fuimicino do not buy the ticket by the airport but walk further to the station, you will save on queuing time!