Perfect location from which you can reach Vatican (Saint Peters square) in about 5 minutes (if you take the underground street crossing). You would would not need a car or too much of public transport, but you must be then prepared to walk extensively to see old Rome city center. We've done (in a relaxed tempo) about 15 km/day.
Would plan to return in the near future for another visit. The place is OK, reasonable good value for your money. Grazie Laura!