Lorenzo's place was perfect! safe, great location. 35 minute walk (3 km) to the Coliseum/, which was the furthest we had to go! everywhere else-- Vatican City, St. Peter's Basilica, Sistine Chapel were 10 minutes walking. Piazza Navona (10 min walk), campo de fiori (15 min walk). The train station was also very close-- about 5-10 min walk. we never used any public transportation once we got to lorenzo's! (I'm 25 and an average healthy person)
The place was clean, very safe, and easy to use! I would absolutely recommend Lorenzo's place!!