Great place to stay and I highly recommend.
We came in late August (Ferragosto) so it is not exactly a bustling neighborhood. However there is a nearby market, and many restaurants. The location is about 3 train stops from "Termini" and about 5-7 away from the Vatican.
The accommodations were very nice, including clean towels, free wifi, hair dryer, a/c, clean sheets.
We would stay again.