If your main goal is to check Vatican this is the right location, just across the street, 3-4 minutes walk. We circled the city on foot and we were fine. Best way to get here is by taxi, depending on luggage you have but if you are travelling light and if your flight is not late as ours (11PM) going public transportation is good. If you have backpack, you can use a scooter from Termini station. Clean and easy place. Walls are a bit thin if you have younger people next door who travel to Rome "just to see each other" but that is ok too. Cassandra is great with answering messages and a kind host.