Nicolo's place is outside the main tourist spots in Rome but close to the train station giving quick access to the Vatican and direct access to other central places. We were on our way out from Italy and stayed overnight at his place before catching a flight next morning so were not worried about the accessibility part. The place itself was clean and well kept with lots of goodies (wine, snacks etc on purchase) available to make for a comfortable evening. Overall a good spot and perfect for us.