Our stay in Denise's apartment was great. The location was perfect. It was very comfortable and well equipped. We cooked dinner a couple of times and the kitchen had everything we needed. There were a couple of grocery stores nearby, as well as lots of restaurants. We enjoyed dinner at Cantine Cavour which was less than 10 min walk. Not touristy. Rome was very busy, so it was lovely to have a comfortable apartment to relax in when we weren't site-seeing. It was less than 15 min walk to the Vatican; a little further to Trevi Fountain and again abit further to Roman Forum. When the kids were a bit tired we got the metro home from the Colosseum, which was very cheap and easy.
Not about the apartment but may help other travellers - we were 2 adults and 3 teenagers and we wanted to see most of the Rome 'sites'. The Vatican cost around £100 (tickets plus audio guide) for the five of us, not booked in advance. It really wasn't enjoyable, it was just a mass of people shuffling along. I know it's a heresy to say so but we were glad to get out! However, the things we enjoyed most were a night-time bike tour (led by www.rex-tours.com). Great fun, whistle-stop tour along beautiful back streets to all the main sites, with a little bit of history chat from the very friendly guide. The second most enjoyable visit was to the Palatine Hill. You could easily spend 5 hours here, its nice open space is in contrast to the crowds elsewhere. Take a picnic blanket and some fruit (not a massive lunch because your bags maybe checked on the way in). Lovely views from the top.
Enjoy your stay - we did!