Location, location, location! Guiseppe's home was comfortable and perfect for my husband and me. It was literally steps from the Pantheon, and a short walk to Trevi fountain, Spanish steps, colosseum, and forum. The Vatican was a bit more of a walk but we did it twice without issue.
Guiseppe was a great host! He was quite responsive, checked in with us half way through our stay, and was courteous and helpful with some great recommendations for coffee and restaurants.
I would highly recommend this location. The only downside would be if stairs are an issue. It is second floor walk up which didn't bother us at all but may be difficult for some travelers.