Valentina's apartment in Rome's Esquilino neighborhood is an excellent location for exploring Rome. It is close to Termini station (train), only a 10 minute walk. There is a metro staircase directly out the front door of the building. Termini is the hub for the metro and you are only one stop away from Termini so getting to the farther parts of the city is easy and fast. There are good restaurants in the area, italian restaurants and many "ethnic" restaurants as well. Grocery stores are nearby if you care to cook for yourself. The kitchen is well equipped for preparing reasonable meals. The apartment is on the fifth floor. There is an elevator. it is small but will carry four reasonably sized people. My family of four rode it up with our luggage but it refused to take us all down (with luggage) when we were leaving (I think it may be a balance-of-weight issue). Be aware that the apartment door locks are not like most italian door locks. you must use the key to lock the door when you leave. We didn't realize this until day 3 but it wasn't a problem. just be aware that if you have valuable stuff, you probably want to be certain that the door is locked when you leave the apartment. I think she also has the next door apartment so if you have noisy neighbors, giving Valentina a call may solve things.
We enjoyed our stay at Valentina's apartment in Esquilino. If your time is limited and you can't afford the time to walk to the sites or you no longer have the energy/ability, this is an excellent base camp for exploring Rome.