Absolutely the best spot to stay in Rome. 3Min walk from Vatican, 2min walk from nice restaurants in borgo (perfect for your wife to wear heels as she doesn't have to walk any far) and 15mins walk from old downtown.
Francesca is the most caring host I've ever met. She took care of us as if we were (me and my SO) her family. Instantly responds to any questions (tickets related, what's the best food to eat in the area. Top!
Lastly, the place itself is new, the bed is amazing and the unique ambient makes you wanna lay down and enjoy the sounds of Roma coming thru the window.
Don't look for anything else, it's the best you can get for this price and being close to everything compensates all sorts of transportation costs.