We are so glad we chose Rafaella's Sistina House! It is centrally located, beautifully decorated and most of all Rafaella is the best. She greeted us warmly and took care of restaurant recommendations and airport transportation. From what we saw of Rome this was the best area to stay in as far as being able to walk to different areas. It is right next to a metro stop which was key for us. Just to clarify this is on the 3rd floor (six half flights of stairs). It might be difficult with heavy suitcases for some but I'm sure if you let Rafaella know she would take care of it. We would definitely recommend!