This place is perfectly situated in Trastevere among a very lively group of shops, restaurants, and bars as well as two nearby Piazzas (public squares) which are frequently attended in the evenings by hundreds of locals! The Vatican is within about 15 minutes by foot. The Roman Forum and Colosseum is a bit further and you may consider taxi/Uber. Most of the attractions and museums in Rome are walkable and within 15 min of Trastevere. But get a map so you can plot out where you’d like to go. The streets (alleys really) seem to wind and interconnect - not really a grid - so it can be easy to get a little turned around.
Of note: there are no direct metro routes to Roma Termini nearby, however, Uber worked when we were there and Alessandro arranged for a car service to pick us up and drop us off at the Train Station (Termini) during our stay.
Overall an amazing apartment and location that we’d love to visit again!!