We had a nice stay in Giovanni's villa. It's very close to the regional train station, so the Vatican is reachable quite quickly; the inner city takes a bit longer.
Giovanni is a great host. He brought and picked us up from Termini so we could get quicker and easier to the villa, helped us with the area and is a very nice person to talk with.
Our room was good, we had enough space and a nice balcony, and the villa has a lot of space as well.