We loved this apartment. It was perfect for what we needed, and gave us a great jumping off place to Vatican activities. Laundry machine and balcony were really nice amenities. Neighborhood is not in the middle of the tourist area, and apartment is on the back of a building away from the noisy side of the street, so it was a quiet oasis in the city.
Because the location is not in the middle of the tourist area, the price you will pay is more cabs and/or transit to get around. But there is plenty in this neighborhood to give you all the necessities right here once you are back.
If you like to walk, it is somewhat difficult to get to and from, as there is a giant hillside and tunnel separating you from the river, so while it's on the west side of the river, getting to Trastavere neighborhood for example is not a straight forward or obvious path.