My best friend and I travelled to Rome for just about a week. We've been several times, so the orientation and use of transportation wasn't a problem. For newbies in Rome it might be a little more inconvenient to get back to the Airbnb after the Metro closes at night. Otherwise the location is great. It's right opposite a massive shopping centre with everything you need, a supermarket, the metro, several bus stops and a train station from which you can reach all the major tran stations.
The check-in was super easy and they were waiting for us on our arrival, gave us a quick tour of the complex (the Airbnb is located in a big apartment complex) and showed us to the apartment.
The Room was designed so incredibly cute, everything is newly furnished, the bathroom is amazing (with bluetooth-mirror) and there's even a tiny refrigerator filled with Joghurts, bottles of water and other snacks you're free to eat. They also set up a lovely tea corner with a cure variety of different flavours, from which you can enjoy your tea with a view on Saint Peter's Basilica and the surrounding town. There's also a nice hillside park (Monte Ciocci) opposite the Airbnb from which you can enjoy the view over almost half of Rome and the Vatican of course.
The apartment was squeaky clean, cutely arranged and so thoughtful. The Aircon provided a cool climate to which one can come back to after a day out in 37°C-Rome and blinds shut out the sun if wanted.
Located in Aurelio, close to Metro Valle Aurelia, you're in town with the Metro in 15-20 min, or by bus in half an hour, which is perfectly fine for Rome - a city in which takes so much longer than usually anyway :) You can also decide to walk to the Vatican within 20-25 min and sit on St. Peters Square and enjoy some take away pasta.
All in all it was an amazing stay and we would both come back at any time!