I was a bit worried about the area as I had only briefly surveyed it in a previous trip, but I must say there was nothing to worry about.
It is safe, we arrived worn out around 22:00. stayed about a week and ran out of toilet paper :O but there is a small supermarket in front. The washer is also great because we could comfortably take care of refreshing used clothes and stay clean.
The metro station is 300m away and 1 stop from Termini, though you will need to haul your luggage upstairs/downstairs there.
We also walked to/from Colosseum the apartment (we are not afraid of walking) and also to Santa Maria Maggiore for mass. So you could saybit is centrally located.
The apartment was clean and mid-stay they replaced towels. We eat sometimes out but also like to cook and eat "home", the place had all the necessary kitchenware so we felt at home. It was just a bit more expensive than expected but it was a last minute trip.