Very convenient being close to the Vatican, metro station and grocery store. Far from all other attractions and neighborhoods such as Spanish steps, Trevi fountain, colosseum etc.. Easy to get to with the metro.
We felt safe. However apartment is close to hospital and we heard tons of sirens. May not be ideal for light sleepers as the all the windows face the entrance and you can hear neighbors enter and gate shut. Overall we had a great stay and would visit again.