Marcella's location is PRIME for reaching all landmarks from the Coliseum, to Santa Maria deep Popolo, Vatican City and Trastavere. The street is a bit noisy at night though fortunately Marcella has good windows to help block out noise when locked, and she provided earplugs in case you didn't bring any. Especially appreciated the travel journal that past guests wrote in great restaurant recommendations and so on. There are a ton of great shops and restaurants just near the apartment also.