Maria was an absolutely lovely host. She was warm, friendly and did everything she could to make sure we were comfortable, The flat is a short, pleasant walk from the Vatican, so it makes sense to start any sightseeing there. For trips to the other sights, take the Metro from Cipro (also a short walk away) as the buses are rather unreliable. The neighbourhood is pleasant and safe - try the gelateria nearby and there are several coffee/breakfast bars for a quick (and surprisingly cheap) cappuccino to start the day. Maria had stocked the fridge with some essentials for us which was very helpful. There is a supermarket very close to the flat and a little corner shop which are both very well stocked. Thanks Maria! We loved Rome.!