Calpurnia House is perfect place for 4 - 5 people. My family of 5 adults stayed there for 3 days in October. Only one bathroom, but its super nice and clean!
We could walk to take the Metro to the Vatican and of course the Coliseum is close by. The location is surrounded by near by cafes and restaurants and small places to buy groceries. There even was a hair salon nearby by that came in handy one day for the ladies in my family. Roberto and Claudia arranged the ride from the airport for us and were waiting at the home when we arrived.
Claudia arranged the taxi for us the day we left. Thank you from the Singer family, Halifax, Nova Scotia, Canada. We would recommend this place for your stay in Rome.