Massimiliano and Claudia are very warm and responsive hosts. The room is comfortable, clean, and very private. It's also totally quiet --nothing will wake you up at night.
The neighborhood is beautiful, and indeed it is close to almost anywhere a tourist might want to go in Rome. I walked to/from the Colosseum, Vatican, Jewish Ghetto (just across the river), Pantheon, Piazza Spagna, and countless other places. Like another reviewer said, it was great to, after all the walking, come back home to this private room in the evenings.
It is safe to walk around the neighborhood, and to walk across the bridges to/from central Rome, at any hour, even late at night. For example, I had to check out very early in the morning (4:30 am) to get to my flight out of Rome in time, and it felt totally ok to walk to the bus (only a couple blocks) at that hour, and also then to wait for the bus at the stop. And btw, the trip to the airport was super easy.
Most definitely, a great place where to stay while visiting Rome.