We had a lovely stay of 5 days at this airBnB.
The location is perfect because it's like 2 minutes from the metro. (San Giovanni).
There are also alot of bus stops in the nearby area wich you could use if the metro doesn't come nearby the place you'd like to visit.
You should know that the breakfast is not at the airbnb, but for us it was at a local restaurant named 'Le Foodie Café Bistrot' wich is a 4 minute walk. We could choose between 3 kinds of breakfasts (Toast, Croissant & Yoghurt). At our first day this was not communicated well with the restaurant so we only got a croissant and orange juice (Italian breakfeast). But after quick response from the host the rest of the days the breakfeast was perfect. The host is quick in her response and immediatly provides help.
!!!!!To get to the Airbnb form Fiumicino airport you can use either use a shuttle buss or train to Termini station in Rome (Train was the best experience for us). From Termini station it is 10 Minutes by Metro to the San Giovanni station wich is in the same street as the Airbnb (4 Minute walk).!!!!!!
The walk to the Colosseum was around 25 to 30 Minutes for us as 'young healthy students'.