I couldn't have chosen a much better place than Giuliano's airbnb. Location is perfect... 5 minutes walk from Roma Termini, 7 minutes walk to Metro (which goes direct to Vatican) and 2 markets to choose from that are both only half a block away. All other major sites in Rome are within waking distance. Went back to Colosseum 3x, everytime on foot, just to get a good angle shot of the Colosseum.
Most importantly in this bnb is my host Giuliano. He met me at the Roma Termini as it was nearing dark when I arrived. When I needed directions, he would not only explain to me but would even show me in detail in google map. When I had time and he also had time, our exchange of stories was nonstop. When he cooked or prepared something, he was happy to share it with me. I am sure his other guests had tasted his octopus salad and tiramisu. With his warm, generous and engaging personality plus the physical comfort of the house, I couldn't help but feel comfortable and safe that his bnb was like home to me. Needless to say, if you want to enjoy Rome and Vatican like I did, stay at Giuliano's airbnb!