You cannot get any closer to the colosseum. It is literally across the street. The metro and bus stop are close by as well as a taxi stand but there was so much to do we barely used them. There is a great restaurant next door and market that is open 24 hours a day if you want to cook a few meals.
Fernando was very attentive. He met us at the agreed upon hour, had water, juice, and cookies waiting for us and would follow up with us to see if I needed anything. Finally, after long hot days sight seeing, it was great to come to the apartment and enjoy nice cool A/C. I highly recommend this place