When we were looking for a Rome apartment for our stay, we wanted to be able to take the Metro around the city so we could see everything. This apartment was perfect. The Metro stop on line A is a short walk down the street. Busses stop close by as well. We took the metro in the morning to get to our tour locations and then in the evening to a location for dinner. It was maybe 15 minutes to get to the Vatican area or the Spanish Steps area- both of which have numerous restaurants.
Another really great plus is the coffee shop/bakery next door. We stopped in every morning for a cafe and pastry just like the locals! There is also a small convenience store across the street.
The apartment was spacious, clean and had everything we needed.
The host was extremely kind in setting up airport transportation to and from the apartment. The drivers did not speak English well so it was great having someone arrange this. It really would be easy to take the Metro from Termini if you had minimal luggage.
Overall, Rome is a special city and the Vatican House apartment is a special spot.