Great place - you cannot get more central than this. We used public transport only to get to and back from Termini, otherwise all sights in Rome were available by foot to us. The Vatican is a 10-minute walk, and the Colosseum 25 minutes. The place is super cool in the summer heat even without turning on the AC, so this is also very pleasant. There are nice cafes and lovely restaurants nearby without it being noisy, as it looks at the inner yard. Communication with the host was excellent, they were kind and helpful. Self-check-in worked great too. The only downsides for us were the lack of natural light and the tiny shower space.