The hosts are very gracious and respond to all questions quickly. The apartment is located in a cobblestoned vicolo (alley, for English speakers) but it is safe and located in easy walking distance to the Pantheon, great restaurants, and the very cool Trastavere area. Just at the end of the vicolo is a major street so it's easy to get a taxi or a bus if you need one. The apartment is large and is a great example of a classic old Roman apartment. It's very clean and the beds (at least the one I slept in) were SO comfortable! The hosts gave great local tips and also arranged for a taxi to pick us up early in the morning to go to the airport.
I highly recommend this location and would happily stay here again when I return to Rome!