This is a lovely apartment which is superbly situated for the Vatican (about 10 mins walk). It's a little further from other mainstream attractions (around 30 - 40 mins walk) but has bus stops within 5 mins walk to major tourist spots and the main rail station. The neighbourhood is quite quiet and fairly residential, with several small mini-markets, a pharmacy, a small supermarket and some great restaurants (try Goose!) all within a 5-10 minute walk from the front door.
The apartment itself is up a hill and is third floor with stairs; so it's fine for most people but those with disabilities or limited mobility may struggle. It was clean, well laid out and had three balconies off the kitchen, lounge and master bedroom. Sliding doors essentially create two en-suite double rooms. Check in and check out was a breeze and Stefania was really quick to come back to messages; never failing to be prompt, friendly and incredibly helpful.
All in all a great experience for less than the per-person cost of a budget or average hotel. Really highly recommended.