Isabella is a wonderful host. She waited for us, even if we arrived really late and help us out with all the information that you would need in a 5 days vacation. The apartment is located really close to Vatican City, 5 mins to the actual Vatican entrance. Also from here to the city center you can either walk the distance, take the subway/metro for 2 or 3 stations or use the bus which has a station right in the front of the building. If you arrive at night there are shops opened late, one located door-to-door with the apartment building entrance. I would warmly recommend Isabella's place for anyone, especially for bigger groups. Really comfy beds and cozy atmosphere !