This home was incredibly well located. Our family is walkers, so we pretty much walked everywhere! The Vatican was about a 15 minute walk and getting to the other side of the river was about 25+ minutes. But this 25 minutes of walking includes great scenery and shopping along the way to your destination. Crossing the river is where you see a whole other side of Rome with a ton of restaurants, plazas, etc. If you don't like walking, don't use Uber. There is a great app called ItTaxi that is exactly like Uber and a driver always met us within 5 minutes. They are EVERYWHERE.
Keep in mind that the bedrooms are very well air conditioned but the kitchen/dining/living room are not...but we managed! Just make sure you stock up on water and ice during the day and stick it in the fridge/freezer.
The hosts were very communicative and they even shuttled us to the Airbnb for cheaper than it would have been for a taxi.