This was a great villa for our group of 10, with a good balance of amenities and location. The neighborhood borders Trastevere and Testaccio, both of which are packed with bars and restaurants, yet the villa itself is on a quiet residential street of gated homes.
We found the location to be extremely convenient -- it's an easy walk from the Roma Trastevere station (with access to the airport), is close to multiple bus lines, and is an easy (5 minute) walk to two of the main electric tram lines (lines 3 and 8, which head up to the Pantheon and Colosseum, respectively). A 1.5-euro transit ticket will get you passage on any Rome metro, bus, or tram... good for 120 minutes from time of validation, I believe (tickets available at local tobacco shops, bars, news stands, stations). It's also possible to take a regional train (FL3) up to the the Vatican from a station that's about a 10 minute walk from the villa (tickets 1 euro each). If you want to stroll all the way to central Rome (or the Vatican), count on roughly a 40-minute walk (we did this a couple of times, checking out the neighborhoods and parks encountered along the way). There's a well-equipped grocery store just a few blocks up the street. And for those arriving by car (as we did), the villa has private, gated parking (in the villa driveway) for a modest daily fee.
The villa itself was well equipped, with a large kitchen, an indoor dining area that will accommodate 10, and several nice outdoor spaces, including a large rooftop terrace that affords views of the surrounding neighborhood and nice evening breezes.
Note: this is probably not great place for anyone who has issues navigating stairs (it's on three levels, including the rooftop level); this was not a problem for our group, but worth considering for anyone with mobility issues. Also worth noting that while the villa (first floor through rooftop, including rooftop terrace) is private and you'll have it to yourself, the outdoor spaces on the main level are shared with residents of a basement apartment. This caused us no concerns or problems. Check-in and check-out went smoothly. The villa caretaker was very patient and accommodating when we had troubles with our rental car that led to a delayed departure.
Our only minor disappointment: the lights on the rooftop terrace weren't working during our stay, making the otherwise fantastic rooftop space a bit less functional and charming than it would have been otherwise.