This truly is a bed and breakfast - breakfast every morning and house keeping every day. The house keeper was also there in the mornings to assust with breakfast in the morning, and they can hold luggage for you after check-in.
This place is only about 6 minutes by foot to the Vatican Museums entrance, and another ~10 to the Basillica.
The only thing i would say to be aware of is to remember that there are other people in other rooms of the apartment. The hosts do have quiet hours noted, but if those guests aren't quiet, you'll be able to hear everything. We were kept up one night by very loud neighbors but they were gone the next night so there wasn't a need to ask them to be quieter going forward.
This place is also very close to a metro stop (~4 minutes) so transportation was easy. Overall a really good experience!