Great location, 2 minutes from the train station.
I chose to do everything on foot, from the bnb to the Coliseum, and from there to the Fontana di Trevi. It was loads of fun!
The staff, Francesco and Rosie, are super amazing and receptive! They will give you tips on the places to check, and they're always available if you need any help.
(Also, I thought Francesco would be an old 80 year old dude, but he's not lol)