Our stay at Domus Hotel was fantastic. The setup of the property is a little unusual but worked great. Imagine a large apartment building or hotel - you enter from the street through a secure door. Domus Hotel is up one flight of stairs - there's also an elevator. Once inside, there's a small reception area and a few common spaces including a dining table, couch, and kitchen. From the common areas are doors that lead to each of 5 individual en suites each with a separate card key similar to what you would see at many hotels today. The only very minor issue we found is that one night when several of us wanted to watch TV, there wasn't a TV in the shared space although each individual bedroom had one. A TV in the main living area would have been nice but given the configuration, I'm not sure where it could have been located.
The property was very nice, very clean, and the host was super communicative and accommodating. The location is very conveniently located - it's about 5 blocks from the nearest Metro stop - and easily within walking distance of the Vatican and St. Peter's. It took us <15 minutes and we walked there twice. There are many conveniently located shops and restaurants and what would typically be called a bodega (though I don't think they use that term in Italy) just outside the entrance. Everything was close and convenient.
The host was also quick to follow up to make sure we didn't have any questions, to see if we needed anything else, etc. I can't recommend Domus Hotel highly enough. Great location, great place, highly recommend!