This place is located within walking distance of (almost) everything we wanted to see in Rome. The building is safe and quiet, the rooms are all stylishly appointed and completely functional. Air conditioning in August was a rare find, and a life-saver for traveling with kids. Tip for young families: there is no tub, but removable shower heads can be mounted low, and you can drop off your laundry at a place down the street and have it clean and folded by the end of the day for about €15
There is also a green space/park a few blocks away for when your kids get bored of fountains and monuments.
There is always someone on call for you. We reached out to Lucrezia when we locked ourselves out on the first day, and she was available.