This location is beyond perfect. We walked everywhere from the Colosseum to the Vatican and Travestere in one day - just wandering to see where the day took us. :) We were there six nights and decided that this was indeed the best area to be. The tourists that flock everywhere during the day quieted at night so strolling the allies to go to dinner or out for cocktails was romantic and peaceful. For groceries, there is a COIN across the river and the minimart down the street is great for wine or snacks. We enjoyed Brassia on the corner for breakfast and our favorite restaurant was Risotteria Melotti Roma nearby. (We are not gluten free and my husband didn't realize it was a risotto place and we are glad he didn't!) When you need a break from wine and pasta, there is an Irish Pub nearby for beer and pub food - they have sports on the tvs too which and it was fun to watch the Rome soccer game. Make sure to walk over to Campo Fiori for flowers for the apartment. We only hopped on a bus once because someone told us we needed to. We walked everywhere. In regards to earplugs as some reviews mentioned, we used them and we were just fine but I truly think you would need them anywhere in Rome.
Lucas was the best agent we've worked with and was very responsive. Definitively have him arrange travel to and from the airport.