Ennio is a great host! Very welcoming, and makes you feel right at home.
We had a very early flight, and Ennio adjusted our check-in time, which was perfect.
The location is right next to the Vatican. It's about a 10-12min walk to the entrance of the Vatican museums. The bus stop is around the corner from which you can go to all ends of Rome.
The neighborhood is very safe and quiet. If you are looking for night life though, this is not the place!
Trastevere is a few bus stops away though, so that worked out for us.
All amenities of the house are available to you, we felt like the entire apartments is to ourselves.