Staying at Federico's was perfect for us. It's a bit away from the tourist areas of Rome, about 10 stops on the nearby and excellent metro system to all the main sites. Advantage of being away from the tourist areas is that the restaurants (mainly Federico's recommendations) are better and cheaper. There is a small cafe very near for breakfast and a supermarket just across the road. Great views from the balcony of the back of the Vatican. All in all, excellent for our 4 day trip with family. Highly recommended.