Valerio's "The Place" was fantastic. It's in an area within walking distance of the Colosseum and the subway to the Vatican but it is outside of the tourist hub so you really get a feel for the neighbor - great food, coffee and food markets are all nearby.
The actual space is very unique and colorful and we found it to be perfect. Valerio was a wonderful host, check in was smooth (he gave us a quick run down of the area) but he let us be after that unless we had questions which, when we messaged him, he answered very promptly!
Great find!