It’s in a quaint neighborhood a stones throw away from the metro station and a bus stop that will take you into downtown Rome. You could walk but could definitely take you about 45 min- 1hr. But very very close to Vatican City. About 10 minute walk. Place is nice and clean, smaller than I imagined but cozy and comfortable for 3 guests. Old infrastructure so everything looks/feels old but otherwise nice and she kept the place very clean. Come highly recommended as far as location, cleanliness and wonderful and friendly host. Responds very fast.