Sited in a cozy little neighborhood, it is very walkable to all the main sites (Colosseum, Roman Forum, Historic center), as well as being close to two streets with little shops and restaurants. Mirko was a great host, waiting for us after our arrival at the airport, and braving the mid-December wind and rain to find us. He then kindly showed us around the house, and gave us a suggestion for dinner (sadly we didn't try the place since it was PACKED when we checked it out later, definitely a local favorite). There are also several shops and restaurants on nearby streets, and the gelato from Fatamorgana is a must-try. The house is also just a few minutes walk from a train station.
The space was slightly smaller than expected, and there is only one actual bed, as one of the double bed is also a pull out bed. The bedroom was in the middle of the living room, kitchen and bathroom, and there are no doors or curtains between the doorways, so that's something to keep in mind if you and your travel buddy have different sleeping schedule/habits, or if one is a light sleeper. There is a nice little outdoor area with a table, which would be great in summer for an meal in open air. While small, everything is well organized and the basics are all covered (pots, pans, utensils, cups, some oil and seasoning etc), so you could certainly cook a few meals or reheat something if desired.