Domenico met us at the apartment at the agreed time. We loved staying at his place, very artsy and pretty spacious (for Rome). The apartment is centrally located with lots of action around. Every major site is within a 30 minute work: Colosseum, Vatican, Pantheon.
There is plenty of nightlife right outside the apartment until 2 am in the morning, can be a little loud if you are a light sleeper.