Not wheelchair accessible. No lift and only 1 very narrow staircase up by 1 floor. Bathroom was luxuriously big though. Despite all this, it's probably still one of the better air BnB options in Rome accessibility-wise. Just travel with a group of friends strong enough and prepared to lift you up and down.
But other than that, really nice place, good location and hosts who recommended all the good food/drink places and attractions to see. Highly recommend.