This is a lovely and historic apartment to use as a home base while exploring Rome. It is very spacious with a bedroom, living room, kitchen, and bathroom. The hosts are extremely communicative - I messaged with Claudia leading up to our stay and Silvia met us to check in and give us an overview of transit options.
As far as location, we found it to be a short (~15 minute) walk to Vatican City and Trastivere, and a slightly longer (~25 minute) walk to the historical city center. The train station is about a 10-12 Euro cab ride. The apartment is right on a bus line, although we did not explore the public transit options personally. There are plenty of restaurants nearby.
The only minor downside is that the apartment does get warm - there is a window A/C unit but it is noisy and struggles to cool down the open floor plan. However I think this is to be expected for summertime in Rome.
All in all I would highly recommend!