we had a great stay at this AirBnB. It was in a great old neighborhood, which was surrounded by tons of great restaurants and within a couple minutes of the Vatican. Metro station is a bit of a walk but doable, however if it isn't hot, walking across the bridge and into the neighborhoods where the awesome fountains and ruins are is doable.
The host was great in both communication and information. The apartment was very clean and nice and while it's on the 4th floor of the building, there is a small elevator that makes trips up with bags effortless.
Definitely recommended as a good place to explore the Vatican and Rome.