We visited Anna's place in June with our families for 5 nights. A large party of 11 with 5 kids. The rooms are spacious for each family, and the porches where enough for all of us gathering and chatting. Two bathrooms helped in order to avoid congestion.
We had great time visiting the city. Transportation is close by (bus) or you can walk for 10 minutes and you right at the metro station. At the same time Vatican is just 20 min walking time.
The host was very kind and helpful (she communicated with us prior to our travel to ask on booking taxi from the airport). On the plus side, is that each morning Anna would bring us freshly baked croissants.
It was the first time I use airbnb for accommodation, so I did not know what to expect wrt room cleaning, towels and linens. We had a minor issue with clean towels renewal, that got solved with a simple phone call. I would imagine it was due to Saint Peter and Paul celebration at the time. Apart from that, there was no real problem. In general cleaning service could be a bit upgraded as well as some kitchen utensils like the espresso maker and the water boiler could be replaced (though it is good that they are provided).
Bottomline, I would recommend this place for families and large groups as it is spacious, budget and convenient for moving around the city.