A perfect place to stay if you're looking for easy walking access to most tourist sites and immediate access to the bars and restaurants on the south side of the Tiver. Right smack in the heart of Trastevere, which made for easy access to nightlife, and a 2 minute walk to the river, within 40 minutes pleasant walking to the Vatican, Coloseum, Pantheon, etc (granted, this was November, so the streets were fairly easy to navigate - foot traffic may move slower in winter).
Domenico's place is cozy - if minimalist - and charmingly funky (I would say more about the jazz shower, but you should experience it firsthand). The only downside to the location is that the young crowd of Trastevere is often out and about until the wee hours of the morning, most days of the week - if noise bothers you for sleeping, earbuds are strongly recommended.
Domenico was a great host, and offered recommendations for transport to the apartment and for eating in the area. [Note: the street name changes twice between the metro stop and the apartment. This confused us, don't let it do so to you!]
Pros: Memorable pad, fantastic location, friendly host
Cons: Can be loud at night
Overall: Great spot - you won't regret it!