This location is very close to the Termini station which we needed at the end of our stay in Rome to get to another city. It isn't super near the Colosseum, maybe a 25-30 min walk. We ended up taking a combination of walking, bus, and taxi to get to other parts of Rome to explore but it was always easy to find a taxi back at night. Valentina and David are very welcoming - David picked us up from the airport and even gave us a mini tour of the town on the way to the house. The place was clean and we appreciated the welcome basket and the tourist info on the surrounding area!