The location is about a 15 to 20 minute walk to the Vatican. The bus station is about a 2 minute walk. There are real local restaurants that are within walking distance too. I loved this home as it was light, bright and newly appointed. Alberto, the host, went above an beyond what I expected. He is caring and wants his guests to enjoy his town. He will give you help regarding the must sees and will explain what buses to take if you are not in the mood to walk. The bus ticketing procedures are simple as are the routes. I highly recommend you download Moovit application on your smartphone too as this will really make getting around Rome that much easier. My daughter and I had a morning flight back to the USA and Alberto even arranged a car service to pick us up early in the morning. What a perfect way to end the perfect trip to Italy!