Damiano’s place is practically right in front of the Coliseum. You have to take 10 steps from the front door, but it’s pretty insane how close it is. I think the location is enough reason to stay here, and if I ever make it back to Rome, I plan to stay here again. There are several bars and restaurants right around the corner. If you are okay with public transportation, there is also a train stop right next to the coliseum that will either take you to all of the major stops, or connect you to all of the stops in a short amount fo time. I don’t think I ever spent more than 10-15 minutes in the train.
I highly suggest staying here!