We've stayed with Vinicio's family for 4 nights. Their hospitality wouldn't be much better.
The room and own bathroom was so clean, comfortable and nicely furnished. Room has large windows so it is always (even in rainy days) spacious and bright. Also it has own balcony where you can smoke. Breakfasts always rich and fresh. Location is nearby the Vatican City and very easy to reach the city center (by bus, train or 20-25 minutes by walk). Neighborhood is good, you can come home safely even at late hours.
Both Vinicio and his wife Francesca are so positive, helpful and kind. You'll not hesitate to ask anything you want. You can chat with them or take a privacy in your room which is silent. It is strongly recommended!