We had a lovely stay here, while its not in the Historic center it is very close to Vatican and we walked into town everyday with no issues. and if you want the Metro is just 10mins walk away.
The bedroom is lovely and big, the bathroom is clean and has nice shower. Just be aware the toilet is very close to the wall, so can be difficult for large people.
Kitchen is on the small side, but we managed to cook everything we needed. perfect for a getaway to this amazing city.
The little patio is nice to sit and have breakfast/evening drink on in the sun.