I stayed at Pigneto65 for 4 nights and it was perfect for all my needs. Ivan was very helpful throughout my stay and provided lots of information about the neighbourhood as well as on how to get to the main sights. Yes, Pigneto is not quite centrally located relative to the historical centre of the city, however, the neighbourhood is lively and has many restaurants and bars. I felt totally safe walking around on my own at night! It is also situated close to the bus and tram lines, and is a 20-30 minute walk to the Colosseum.
The flat itself is a good size for 1-2 travelers and comes with everything you could need for a short or long stay. I would love to stay here again if I return to Rome!