Stay here!! Seriously.
Location:
There is a bus stop nearby that leads to the Vatican and a little bit of a walk to the metro where you can reach anywhere in the city.
The room: you get more than 1 pillow! (Extra bonus when you have stayed in any other Airbnb.) private bathroom, the room gets cleaned EVERYDAY! Air conditioning, and a simple breakfast.
Communication: Anna was so quick to respond and got us right away when we arrived to the Airbnb. They gave us a clear run down of the place and area. They even give us the best food recommendations. Seriously, the best food we had the entire trip!
This is a great place to stay!