I would highly recommend renting Mariastella’s apartment. There were eight in our party and it was absolutely perfect. The apartment was large and roomy and very clean and comfortable. It had everything we needed
The area we were in was very safe and had numerous excellent restaurants. We explored the city by day and returned to eat in the area at night. The restaurants were all reasonably priced. It is very easy to get to the Vatican by walking or by bus.
One final note on our host Mariastella. She was so professional. Her communication was superb. Every question was answered clearly and accurately. She provided great documentation that we used every day. You can book the best hotel in Rome, but you will not get better support than you will get from Mariastella