Anna’s place is great and right across the street from Vatican city. There is a tunnel on the restaurant side that will get you to the Vatican homeless are there but don’t bother you. There is a usual 15-25 minute walk to get to Tresevere lively area. You need a bus pass to get to Trevi fountain and all the lovely plazas in the area. Leave early to get to Colisseum, forum sites it’s a little tricky to get there if your not familiar with the area.