This apartment is conveniently located in Rome close to the historic center and the Borghese gardens. Close to Donatella's apartment you'll find the museum MAXXI, a very interesting museum designed by Zaha Hadid. We also visited the kids museum where you need to book in advance and a Michelin-starred restaurant serving molecular Italian dishes. You can walk along the river, but take the opposite side of the appartment. It's a relatively fast and low noise walk to the Vatican. Finally, next to the kids museum there is a little "flea market" where they sell second hand fashion, stamps, design items etc. This was a nice discovery after having tried to take in the historic center in just a few days.
Should you have any inconveniences or doubts Donatella replies very fast and is an elegant host with a friendly attitude.