Excellent location! You can practically walk everywhere in the Rome city historic center. I'm sure everything on your itinerary from Vatican Cit to Colosseum are in walking distance (depends also on how much you'd prefer walking). Bus stop is pretty close so if you prefer to take the bus that is also an easy option. Apart from the location, the room is large, spacious and charming. The locality is very lively from day to night and feels very safe. Viktor was a great host. He accommodated our late check-in and late check-out request. He was very hospitable and good to talk to.
Overall, great experience. Loved Rome!!