We very much enjoyed our stay at the home of Paola in Ostia Antica. She is a fast, funny spark plug of a woman who we came to love. She was very accommodating and helped us negotiate our first jet-laggy days. We highly recommend Paola's place, located in a fairly quiet residential neighborhood.
Easy access to Rome and to the Lido (seaside). Once you get oriented, it is a ten minute walk from Paola's to the center of Ostia Antica where you will find four restaurants/cafes, of which we ate at three and loved. We became regulars at l'Alimentari, but also found two great little trattorie nestled in the nearby alley. In any case, you will eat well.
We spent some hours at the ruins of Ostia Antica, which is in easy walking distance from Paola's and it's spectacular. This is a ruin of an entire small city. The headphone tour guide is totally worth the 5 Euros.
We also accidentally saw Pope Francis, who was celebrating an outdoor public mass at in Ostia on the day we arrived (I don't think it was for us).
Buon viaggio!