I highly recommend staying with Francesca and her family at her home in the lovely neighborhood of Trastevere. It's just outside the touristy part of the area, and makes a great home base for exploring Rome. Just a block away from a tram stop and very easy to reach from FCO via the regional train with a station 10 minutes away. Felt safe in the area as a solo female traveler. Francesca is very welcoming and helped to make my first visit to Rome an enjoyable one!