If you are looking for a rental in a beautiful, history soaked neighborhood - this might be a good fit for you. This was my fourth stay in Rome. My first in the Jewish ghetto. I WILL be back. This place is located just steps from the Portico di Ottavia on a lovely pedestrian street packed with restaurants. Also, you're only a block from the river and the enchanting Tiber Island. You couldn't ask for a better, more central location.
The apartment itself is beautiful and full of historic touches that remind you where you are. The main bedroom is lofted over the living room and is very spacious. The other bedroom is lofted over the dining room and kitchen. It's a little tight up there, but it's two single beds serve their purpose. The only drawback to this place is its lack of air conditioning. There were 3 fans (one per bed), but in the summer heat it did get quite hot - especially in the lofted bedrooms. Definitely a consideration if your visiting between June and September.
Last, the guy who handed off the keys and gave us a run through of the apartment was flexible, thorough, and very helpful. That's always nice. Anyway, a very cool base for a Roman holiday.