Domus Colosseum is the perfect location for a Rome visit. It is right around the corner from the Colosseum and many ruins. There is easy walking to other sites and quick access to the Metro which will take you almost anywhere you want to go.
If you cook in, the kitchen has the equipment and there are nearby grocery stores. If you want to eat out, there are little, wonderful cafes nearby. .. I mean steps outside the door!
Andrea is a wonderful host who will give you good guidance and accurate recommendations.