Andrea's place is located close to the Vatican and is ideal for visits to that area. Bus 64 takes you almost to the door from Termini Station and the same bus will take you to locations within the historic centre of Rome. The Tiber is within easy walking distance.
The room is in a very quiet area (no traffic), there is a concierge at the main entrance of the building for most of the day, Facilities inside the room are excellent. Andrea and his assistant are extremely helpful and will even allow you to bring you bags before check-in and leave them there after check-in.
Strongly recommended.