We have stayed in many Air B&B places over a number of years and Marco's Place is one of the most beautiful we have ever experienced. The original features of the 17th century pharmacy are extraordinary and the simple, clean and very clever interior architecture/design truly makes the accomodation.
The bed was very comfortable, and the apartment is quiet. We made use of the lounge area spending time reading, and the courtyard outside for morning cloud and swallow watching over coffee. We used the kitchen every day and found the simple set up easy to use.
In terms of accessibility, this apartment is a minute's walk to the nearest train station and is one stop from Bologna Central (the city's main train station). If you have wheels (wheelchair for example), this would be a more accessible choice with no stairs in or to access the ground floor apartment (apart from courtyard at the rear) and flat terrain to the train stop. The local trains are wheelchair accessible also. The apartment has parkland nearby, and you can walk along the river which is not far either. The area is safe and has a local community vibe.
Our hosts were highly accomodating, communicative, responsive and thoughtful. If you seek somewhere beautiful to stay, this is the place.