The house is neat and clean, in a neighborhood that feels safe and not too touristy. A few minutes from there, you can have breakfast and coffee on Piazza Carlo III (where you can also take a taxi). You can walk to Napoli train station in 15 minutes. Several buses come close to the house and connect you to the city center (Museum, spanish quarter...) but beware of buses in Napoli, they can't be trusted too much..!
Overall, we really enjoyed our stay but you should expect to walk a lot (it does make you feel that pizza is well-deserved :) ), and Giuseppe was very kind and always available!