The location is really well connected, within walking distance to the metro stations of Università (the University), Duomo (the Cathedral), and Toledo (the bustling walking street and shopping neighborhood).
But you don't need to use the metro or buses in case you like to explore the Historical Center, from here, you can walk to the Spaccanapoli, the Spanish Quarters and Toledo (connected to the seashore), the Decumanus Maximus or Via dei Tribunali.
The host lady doesn't live in the place, but she is accommodating and welcome, if you need to ask anything, send her a message and she will be available in a short while. The room is small but cosy, suitable for a couple or even a single person.