I am sure when I looked at the reviews of this place I read that there are a lot of stairs but I most have underestimated it or not believed it. Let me reassure you: There are a lot of stairs. Generally this would not be a problem because I am a young man and I traveled with a carry on backpack, however I traveled with my girlfriend and her mom and ended up lugging their suitcases up the stairs as well. My main suggestion is to just be wary about the amount of stairs that you will climb/descend.
The other big thing is entering the BnB. You are on a alleyway with graffiti walls and may feel a little uneasy. Claudio did not come to meet me so it took a while to find my way to the right place because I was not expecting a large graffitied wooden door. The inside however is nice and feels very safe.
Also, one issue I seem to be having with all the places I stay in Italy is the amount of hot water available. After 1 shower there was no more hot water available for the other 2 people to shower so plan accordingly. (That’s based off of a 10 minute shower max)