If you're doing the hop-on hop-off bus in Dublin (through the Dublin Pass especially) the stop is right outside the building. Since we were using the hop-on hop-off tour this was fantastic. Not to mention the views of Guinness were fantastic.
You can get coffee from Insomnia or Costa right around the corner. There is a great bar, with amazing Toasties just a block away called Mission Bar. Rob is an amazing bar tender there with some great local suggestions for food and entertainment.
My only real complaints are parking is problematic and the beds were not comfortable (and limited pillows). We ended up leaving the car in the Four Squares Quay parking garage for the two days we were there, and just using the tour bus and going on foot. That said, for the convenience and location it is hard to beat. Also, be prepared, it is a walk.up (no elevator).