All in all the Airbnb is a perfect place to relax and enjoy a little silence far from crowded and touristic places. They helped us renting an ATV. With an ATV it takes approximately 25 minutes to reach Oia in the north or the lighthouse in the south. Without the ATV getting around is a little bit more difficult. The Bus leaves from Messaria center which is in walking distance (10-15 minutes) and departes to Fira (takes about 15 minutes). Messaria center also offers a few restaurants and supermarkets.
The apartment itself was perfectly clean and had a little balcony. Our hosts provides coffee for us every morning and helped us with recommendations on what to see and where to go on the island. So all in all, great accommodation with a nice pool, very friendly hosts, but not in the center of all the touristic places and nightlife :)