Let me start by saying that George's Canava House is better than the pictures, which I did not believe was possible. It is a beautiful cave style home that easily accommodated our family of four. The beds were comfortable and there was plenty of room for personal space. It is beautifully decorated with a sense of history in it. It is well kept and there is a cleaning service everyday, if wanted. The outdoor courtyard common area is extremely relaxing. There is also an upstairs outdoor common area with a grilling area that overlooks a quintessential blue dome church. The view at night is amazing.
The house is located within a very short walking distance of the center of town. There are several markets and restaurants right there, if you are not venturing out to Oia, Thera, or Kamiri Beach (black sand beach). Sergena and Mike's were our favorites.
Thera and Kamiri are easily accessible by bus from the house, right at the town center. But if you are going to Oia, ask George and he will schedule a car service for you. Oia is accessible by bus and taxi, but after sundown it can be a little crazy trying catch the bus or get a taxi.
George is a great host, he scheduled a car service to pick us up from the port, as well as a ride to the port on departing (you pay the driver, but a luxury shuttle service is definitely better than a taxi, and probably cheaper) . He met us at the house and walked us through everything we needed to know, showed us where to visit and where to skip, which restaurants to go, how to get around the island. He even provided a cell phone that had his number in it to ensure that we could always reach him. The island's cell service is a little spotty.
If you are visiting Santorini, this is place to stay. It is close to everything, but just far enough that you don't feel rushed and crammed by the crowds. George is a great host and is always available and quick to respond.