Villa Calderini is beautiful, we had a perfect stay for two nights. It's big enough for two couples, has a wonderful terrace overlooking both sides of the island and the kitchen is extremely well equipped. Also, you can walk to Thera in 15/20 minutes. Absolutely suggested. (Be aware that location given by airbnb through "receive indications" is wrong and will take you somewhere else, put "Villa Calderini" on GMaps.)