I enjoyed my stay at Hotel Mathios! It was very clean and was a good location to be in if you want a slower pace of the island. Fira and Oia are great cities but Akrotiri is definitely less crowded and a more quiet side of the island. I was able to walk to the Red Beach, Caldera Beach and the museum. I also took a couple evening runs to the lighthouse. I was worried about getting to Hotel Mathios from the airport but all you need to do is take a city bus to Fira from the airport for 1,60 Euros. Then take the city bus to Akrotiri and have them drop you off at Mathios Village. The drivers all know the stop.