Great location, (as long as you're capable of climbing 50-70 stairs to get to the Airbnb. ) You'll be greeted with a wonderful view, extremely spacious space, right in the middle of Fira.
The only negative I could think of is that you will have to deal with dance music from the club overhead throughout the night. If you are a light sleeper, I would recommend a pair of earplugs. Otherwise, the stay was wonderful.