I can’t recommend Afroditi’s house enough!
It’s in a fantastic location in Livadi, right next to the port so very easy to get to from the ferry and you are surrounded by lovely restaurants, cafes and bakeries. Close by are also a number of scooter/car rental companies so you can get around the island easily.
Afroditi was very welcoming, meeting us when we arrived and giving us all the information we needed about Serifos, and the house its self was extremely well equipped and really spacious. (The view from the balcony is absolutely beautiful too.)
We will definitely be coming back!