This residence is some 1km from Fira's main bus station along the main road. While it is not exactly far from the bus station, a first-time visitor may have trouble finding the place.
Suggest you contact the host to pick you up from your airport/bus station. It's a shame that a family-run lodging could not do more to help guests (apparently, they offer free airport pickups, but not dropoffs - when I inquired, I was initially advised the "partner" does not do drop-off when the person picking you up is actually the father of the host you will be communicating with) in this regard. I was eventually picked up at the Fira bus station.
That aside, the hosts were exemplary though as the room was fairly spacious for the price. There are some nice eateries and super market just along the main road and there is a bus stop serving bus services to/from Akrotiri and Kameni (this was of little use to me as I arrived from Oia, whose buses don't stop here en route to the Fira station).
Overall, a good base for your Santorini excursions, especially if you rely extensively on the public buses.