Antonis' place was just spectacular. It is designed to look like a cave house - looks much better in person than in the pictures. The location is key. Mesaria is close to the port and away from the tourist-centered places like Oia and Fira. The local bus-stop is a 3 minute walk. The bus stop area is like the town center. There are restaurants, cafes and ATV/Car rental spots there. Definitely check out Mike's Grill house. The food (traditional) and service are spectacular. There is also a large supermarket literally across the Airbnb.
Antonis' place felt secure. The doors and windows had secure locks. The cleaning lady would come every day between 10-12pm to replace the towels and tidy up a bit. The host is a very nice gentleman. He went out of his way to get us a wine opener in the middle of the night even though we had told him we would manage without it. He quickly responded to all our texts and was willing to answer all our questions about the island.