I highly recommend a stay at Lefteris House! The hospitality is absolutely incredible with the rooms being cleaned every day and tons of tips upon arrival. It's a five minute walk to Karterados bus stop, where you can catch the bus to Akrotiri, Kamari, Perissa, and the airport. It's a little bit outside of Fira, so it's quiet at night, but is also only a five minute walk to a supermarket to pick up water or other groceries and a great bakery to grab coffee in the morning. The walk to Fira is about 15 minutes, so keep that in mind when making your plans for the day. This was such a great place to spend our time in Santorini!