Our (my friend and I) time in Santorini was wonderful, in part because of how great of a stay we had with Panos. He is a host that truly cares about his guests -- responds quickly to requests, gives great local tips, and was even nice enough to drive us to the airport for our return flight.
The only thing I would mention is that the place is difficult to find, in part because of where AirBnB places the location. I would ask Panos before you stay for more specific instructions on how to get to the BnB. Overall, I would highly recommend staying with Panos in beautiful Imerovigli.