This is an absolutely amazing house, you'll struggle to find anything better in Crete!! It has everything you need for a relaxing and enjoyable holiday. The hosts are incredibly kind, helpful, and welcoming. The views are spectacular and the area is lovely to explore. If you're looking for a remote, quiet, beautiful, relaxing destination, with plenty of natural beauty, crystal clear seawater, and enjoyable walking trails, this is the ideal house!
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We spent 7 nights here, without a car. A car is definitely recommended (!), but not essential IF you are outdoorsy and enjoy hiking - I would say we did around 12-18km of walking a day to get to and from the coast and the nearest large village. Here are some tips about how to come to this house without one. We took a taxi from Heraklion airport directly to the house - this cost ~120€. On the way back we organized a cab with the taxi drivers of Mochlos (http://www.mochlos.eu/index.php?action=page.1) and it was the same price.
Getting food is the only issue without a car. The best way to do this would be to walk to the village Mochlos (1hr 20min downhill, through olive groves), visit the mini-market, and get a taxi back to the house (~15€). Mochlos is a beautiful fishing village, with lots of cafes/restaurants and you can easily spend several days there. The water is crystal clear, the sea is calm and there are beautiful little fish - bring your goggles! We got a bus to Sitia, which has a larger supermarket, however, the mini-market in Mochlos would have been just as good. Sitia has a nice sandy beach, so getting a bus there is also worth it. The local tavern is ~10/15-minute walk, has incredible views, delicious food, and is very well priced. We spent a couple of very enjoyable nights there. My advice would be to get to Mochlos as soon as you can and buy enough food for your stay. If you can't get there on your first day, then have your first-day dinner at the local tavern and walk to Mochlos to stock up on food the next day (maybe buy some snacks from the airport for the walk too).
If you enjoy walking you can get down to the coast directly from the house, walking between lovely olive groves. We found a beautiful pebble beach. It was small, but secluded so we had it all to ourselves.
Overall, this house is a no brainer. I would come back in a heartbeat, and hope to do so again next year! If you can drive, rent a car - it will make it easier and mean you can explore more of eastern Crete. If you can't drive, you can still do it, just make sure you enjoy walking and exploring!