If you are looking for a fully self contained holiday villa, then Killixeni is definitely the spot for you. It is so modern and everything you could need is provided plus you will have the most perfect host in Kalia. The location is superb and the outdoor facilities are simply the best. It is located above a small village about 8km from Rethymno (a bus runs into Rethymno every 3 hours for 3.2euro return) and there are 3 really good restaurants plus a bakery, a pharmacy and 2 small supermarkets as well as a number of cafes.
I highly recommend Kallixeni villas but beware there are a lot of hills to climb in the village so it`s only for those who are good walkers.