We stayed 7 nights at Maria's location as part of our honeymoon trip in Greece. We debated renting a car and we are extremely glad we did - it highly enhanced our trip as we could get to local beaches within 15-20 mins and drive to must see spots that were 2+ hours away. I would not rely on the transport systems of you are trying to see as much of Crete as possible while time constrained. As for the apartment, the area is very residential but close to Old Town by car. The pool was great and very refreshing. This was exceptional value relative to other hotels and listings. A few cons - it was very hard to find and didn't come up on GoogleMaps; Maria was able to pick us up and was very helpful. The wifi does not work in the apartment - only on the patio. Hopefully this will be fixed in the future as it's 100% necessary to plan out trip details online inside when resting.
Overall - highly recommend this to other travellers. It's a great size and the kitchen was handy.