Ioannis is probably the best host that AirBnB has to offer. He was one of the most accommodating, kind people! He is so proud of the house, and the island, it's truly infectious. Askyfou is perfect. In the middle of the mountains, the only thing you can hear are goat bells, it's magical. One day Ioannis came to change the sheets in the middle of the week (also to bring us some fresh food, because we hadn't brought a car... I would not advise anyone else taking advantage of his kind nature by doing this, we were foolish - take a car!) and he drove us back to his home town of Rethymo so we could spend the day there. We had the most delicious meal at a harbour restaurant he recommended, Kinossos, where they were thrilled to hear his name. We were three couples and there was more than enough room for us. We had a private bedroom each, all of them with an ensuite. One of the bedrooms is basically in it's own annex - it's quite phenomenal. I cannot sing Askyfou and Iaonnis's praises enough - it was an unforgettable holiday and we will most certainly be back.

Practicality wise - it is just over an hour drive from Chania. If you have to check out early and your flight is late, there is a bus station there where you can leave your bags (another tip from Ioannis).
There is a mini market 30 mins walk from the villa where they have some fresh veg, dried foods and alcohol.
There is a bakery a few doors down from the mini market and also a deli with fresh meat and cheese behind that.
It is doable without a car, just make sure that you have transport organised from the airport and that you can stock up on fresh food for the week. You won't want to leave anyway.