My wife and I stayed at Domus Mare Villa II for 5 nights. What an absolutely beautiful place!
The weather was fantastic during our stay in late October as you place is situated facing southwest, so you get sun all day, The views were amazing from Sunrise to sunset!
The road in is a bit tricky but when driven slow, it is not an issue.
One thing I would recommend is that you buy all you supplies prior to getting to Domus Mare. It is well set up so that you can just unwind and enjoy.
I like to cook so I planned ahead so not to have to drive daily. The place has all the supplies needed for both cooking and eating utensils. There are some spices and such but it would be best to plan ahead an buy what you need for any inhouse cooking and do not assume its already there.
There was a large amount of fruit that was left for us upon our arrival which was a nice touch and was greatly appreciated. The people of Crete were very friendly and helpful so it was very easy to get into vacation mode here. We very much enjoyed the whole trip.
Overall, we would highly recommend Domus Mare in Crete for a trip to a beautiful location.