This is a slightly-gritty, slightly-hip part of Athens with a mish-mash of new popular restaurants and shops and concrete buildings that are worn and possibly empty. We felt comfortable as a group but the ladies with us would not feel safe walking alone at night (which is also typical of most places that are unfamiliar).
You definitely can not see the Acropolis from the apartment and it’s about a 15 minute walk away but through a more “touristy” part of the city so the walk is enjoyable.
We had a nice time in the city and the apartment was quite spacious. It is up 4 small flights of stairs.