Manos and Antigone's place is clean and spacious, as well as decorated with lots of color and a touch of humour. I've always enjoyed the Plaka, which despite being the tourist center of Greece, is actually often relatively quiet when compared to other Athens neighborhoods. Not to mention that the old homes, winding streets and frequent views of the Acropolis add interest to the area. And if you're in town specifically to visit tourist sites, it can't be beat. Everything from the Acropolis itself to the new Acropolis Museum is within easy walking distance.