Location! Location! Location! We didn't even realize how amazing this place was for location. Of course the view of the Acropolis, from the living room chairs and even the bathtub, is amazing; but being able to just literally walk down the street & around the corner to Iroon Sq for a late night dinner, dessert, and breakfast was the best. We also walked out the door and over a few blocks to get right into the Agora.
Safety: Walking down lighted streets with plenty of locals we felt just fine in terms of safety of the neighborhood even at midnight.
Bathroom: The bathroom was a little different than we are accustomed to but manageable - no toilet paper can go in the toilet and the shower is just the whole bathroom.
Transport: We walked everywhere, but passed the subway everyday. And getting a taxi from the end of the street to return to the airport, was not trouble at all.
Amenities: The place was spotless and comfortable. The linens were good - both sheets and blankets, and an extra throw to meet the temperature variations. Even small needs such as instant coffee & milk, tissues, and extra international plug adapters were already available.
I would absolutely recommend the place.