This is a fantastic place to stay… you are not in the middle of the tourist hype, but 50m from the metro so you can get anywhere easily… including the Acropolis, Syntagma Square, and Monastiraki. Eat with the locals in the restaurants of the area.
Not only a great place and location, but fantastic hosts. Spyros and Anastasia have constant communication and provide a guide book and recommendations. I would stay here again in a heartbeat.