The experience of staying at Despoina's appartment is absolutely amazing, by far our best Airbnb experience. We cannot recommend it enough. This was so for three main reasons: the apartment itself, the location and the hosts.
1) The apartment is beautiful, spacious and has all one would possibly need. The bathroom is huge, something rarely found in Plaka as we could see when checking other possible places to stay. Bed is very comfortable, kitchenette is super equipped. The apartment is extremely quiet and peaceful. Being right in the center of the city all you would hear are birds flying over the Acropolis. The beautiful patio inside the house makes it very picturesque and relaxing.
2) The location is unbeatable. In the middle of Plaka, it would take you max 10-15 minutes on foot to reach all main spots in the city center: acropolis, syntagma (5 minutes walking, literally), monastiraki, keramikos, national gardens, kolonaki, main museums. We didn't take the metro even once. The area is absolutely safe, you can walk in and out at any time with no problem.
3) The hosts make you feel as you are really their guests. We had never come across such friendly, generous and welcoming hosts as Despoina and her husband. They helped us with everything we needed and actually spoilt us everyday of our stay :)

In sum, this is the PERFECT place to stay in Athens!