I spent a week with my husband and two kids (10 and 16) at Simone's and we all loved the quiet neighborhood and the nice, clean appartment in the eastern part of the city. You are in the U-Bahn in 2 minutes walk and it takes about 5 more minutes to get to Alexanderplatz. In addition, you shall have a great host - super nice and attentive, always there for any question or advice. Would definitely recommend.