Our family of five enjoyed staying in the non-touristy Zizkov neighborhood. Jan was a sweetheart, very nice at check-in and sending messages throughout our stay to offer suggestions and check on us. The apartment was spotless, with a large kitchen and great bathroom/shower. The building (which does not have an elevator, in case that is important to you) has a beautiful garden on the ground floor that you can use (with picnic table). Jan is the gardener. The location is ideal, at the northern tip of Zizkov, but also near the Karlin neighborhood, which was also nice. The Old Town was also an easy walk, and a convenient tram line (which we took to see a soccer game in the outskirts) makes longer trips a breeze. The main train station is also nearby (although the walk from the train station is not as pretty as other Prague walks, it is convenient). If you are looking for a more "local" experience, I would highly recommend this (it was a nice respite from the congested central Old Town streets).