The place is 15-20 mins by tram to the main attractions, but a lot of trams pass by the area. I had no problems coming from the train station via tram. However, note that the streets all over Prague are made of cobblestones so it might be better to just use Bolt.
The neighborhood is a quiet residential area but there are a lot of good cafes and restaurants nearby that are open until late.
The place is spacious and has all the published amenities. It has an elevator so no worries on your luggage. Wifi is fast and you can login to your Netflix acct on the tv. We also cooked in the unit and everything we needed was available.
Host provided clear check-in/out instructions. She also responded quite fast with all my queries. She also let me leave my luggage for a bit on my check-out date as my flight was later in the afternoon.
I had a great experience in this airbnb. :)