This location worked well for our family. My daughter had a conference in Vinohradsky a 4 minute walk away from the apartment and the old town was only a 25 minute walk away, through Wenceslas Square, for my wife and I. Transit, metro and cable car, was only a 4 minute walk away. Prague has a very good transit system(however you need change to purchase the tickets) and you can get anywhere in the city easily. Another nice touch, was that Sarah arranged a transfer to/from the airport for an Uber like fee.