The houseboat was truly spectacular and unique, I'd highly recommend staying here. The houseboat is located in a very quiet part of Prague that is easily accessible by tram 12 or 24. The trip from Old Town to the houseboat took about 20 minutes and we traveled to Terezin by bus and we were able to access the bus station in about 10 minutes.
There is a grocery store nearby along with several good restaurants in the area.