This is my favourite Airbnb stay so far; I stayed with a friend earlier in the year, and decided to book again when I returned to Prague.
Michal's apartment has so much going for it, spacious, sparklingly clean, stylishly decked-out, well lit. It's very well located; you're ten minutes away on foot from the city centre, so you're tucked away from tourism. If you want direct access to Prague along with some peace and quiet, this apartment is perfect! There are plenty of restaurants, a cinema, you're a short walk from the contemporary art museum, trams are available a street away. Plenty of pubs, cafés and bakeries to find authentic Czech food :).
Michal's a wonderful host, he's warm, available and easygoing, leaving plenty of information and tips on how best to enjoy your stay in Prague. He's very responsive so you should have no problems.
I thoroughly recommend a stay at Michal's place, you'll feel right at home, with a lovely place and a great host, within one of the best spots to go out and explore. Five stars!