I visited Prague with my wife and this was my first Airbnb experience and it was honestly quite great. Apartment was really big for 2 persons and well maintained from inside. We had all the amenities inside and it was quite comfortable. Also, the place is not too far from the old town and it's just 15min walk though it has tram station nearby, so commute is not a problem. There were good restaurants nearby along with grocery store, so it is quite convenient if you are tired and just want to spend your evening near your place.
On the negative side, there was no lift in the building and it was located on 3rd floor, so it caused some inconvenience while checking in.
Overall, we had a great stay in our first Airbnb and would love to visit again.