As a native born Czech who now resides in the USA when I travel back to CZ we hardly ever stay downtown. We prefer to chose places that are located fairly close to public transportation, not too far away from the airport and owned by locals.
This ABandB met all of these requirements. It was clean and the owner had the place fully stocked including coffee for an espresso maker. All you need to do is bring your clothes.
Getting around by public transportation:
We took the #9 tram from tram stop KREMATORIUM MOTOL in the direction of SPOJOVACÍ (you board on side of cemetery). This tram makes a stop at ANDĚL which is a huge shopping/restaurant area plus the METRO B stop which will take you to METRO stop MUSTEK a connection stop for METRO stops A and C. You can also stay on the tram to stops NÁRODNÍ DIVADLO or NÁRODNÍ TŘÍDA and walk around the city center from these stops.
Tip from owner: you can take a shortcut through the cemetery to the tram stop and no it’s not creepy. Leaving their place you go downhill make 1st left down an alley into a park setting which is the cemetery. Stay on the main path and it comes out right by the road and tram stop.
When taking tram #9 back go in direction of SÍDLIŠTĚ ŘEPY and get off at KREMATORIUM MOTOL. Make sure to pay attention because sometimes you can’t hear the announcements.