Sarah and Matous' home is beautiful and very centrally located. They were fantastic hosts - waited for our arrival late at night to show us around the place. They even have their own high quality guide to Prague, including where to exchange currency (don't do it in the airport, very bad rates), best foods, transport, etc. Their place was extremely clean and spacious.
The only thing was the place is centrally located and hence can get very loud at night on the weekend. People partying on the streets can be heard loudly on Saturday night. I slept fine but this may bother some. Also, the wifi is relatively weak in terms of speed, so don't expect too much. Overall fantastic stay and would recommend without hesitation.