We had an incredible time in Praguge 11-17-13 thru 11-23-13 all made simple and accessible by Mark's apartment in the heart of Stare Mesto. Although there is so much to do, we followed several of Mark's suggestions on what to see and do, including a meal at the authentic and historic UMedvidku nearby. We even took a day trip by bus out to Kunta Hora to see the Bones Church.
Other than that and the Prague castle, by tram, everything else is within walking distance.
The apartment is located at a major tram stop and the subway is a few blocks away. From the airport it is a short bus ride #119 to the subway metro green line A, and takes less than an hour from PRG.
Mark's apartment was base camp for us and you will feel like you're living just the locals of Prague. We could have shopped at the local groceries, eg, Billa, and made all our meals, but we chose to eat out more often than not and sample the varied local cuisine.
There is a tiny two person elevator to take you to the fifth floor, we never had to wait for it and it seemed like only we used it.
The apartment has internet which we used to access utube for evening video recreation after a long day of walking and sight seeing. PRG does not receive netflix or huluplus, so utube came in handy.

(If you have a student ID, bring it as discounts abound in Prague, and ditto for Seniors.) The beds were comfy and my daughter slept very well in the pull out sofa bed.

Late November is considered off season and PRG was teeming with people, so I can't imagine how busy it must be in peak season. We didn't need a reservation for UMedvidku but in peak you would no doubt.

All in all, we highly recommend Mark's place, a gracious accommodating host.