First of all this was the best airbnb I ever stayed. Host is so much caring about the guests. Right from local tips to prompt reply. Each and every facility had been crafted carefully and decorated mindfully. I never felt I was away from home. Public transportation is great. Take 170/118 bus from severozapadni (next door bus stop to Budejovik bus stop. Budejovik is metro stop also where you can reach muzeum or Praha Hlavni Nadrazi as desired via red line. In all it takes 20 minutes to city Centre with only 150 meters of walking. This appartment is highly recommended.