The location is fantastic for transport, you're basically on top of Florenc station, which is at a junction of two subway lines. There are also buses and trams right nearby, and Old Prague is only 10 minutes' walk away if you're happy to walk.
Downside - you're basically on top of Florenc station, it gets noisy outside early in the morning, and with curtains that are basically see-through, it gets very light very early as well in summer, so you'll be waking early.
This is basically a managed apartment rather than somebody's home, so it's quite an impersonal experience, and you'll be picking up the keys across town in a separate office and paying the city taxes in cash (CZK or Euro) before you can check in.