I couldn't recommend staying at Klara's airbnb more. It is incredibly clean and has basically everything you could possibly need over your stay.
It is located round the corner from two tram stops that get you to basically everywhere you'll need to go. The street has a few bars nearby to have it be lively, but not too many that it's disruptive.
Klara was incredibly kind in meeting us early due to having an early flight into Prague, so we didn't have to wait around. She provided lots of helpful information about getting round the city and tips for great places to go and things to see in each district.
A beautiful airbnb and a memorable stay.