Out visit to Anna's Lovely Apartment was a very nice experience, we stayed for 4 nights here. Anna has prepared almost an entire "book" with all possible tips that you will need, like: currency, restaurants, Prague walking itineraries, transportation inside Prague, etc.
The apartment is very close to the city center, the tram station is 20 meters away and the the metro station is 1 station buy tram or walking.
Off course, maybe the apartment is a little bit too small, but for us was not a problem.