I highly recommend Lenka's cottage. You get the best of Prague by staying here: it's secluded from touristy hubs but is only 10-15 minutes away from the Prague Castle area and 15-17 minutes away from the Old Town. As someone who appreciated the Prague nightlife but didn't want to deal with intensity of staying in Old Town, I loved the cottage. Plus, it is so convenient to have the restaurant next door for morning coffee or a Czech dinner.