Jaroslav's place is in an amazing location. It's steps to the Charles Bridge (so you can get up early and walk or jog it before it's packed with tourists). The location is very close (5 min walk) to ta metro station and just a couple stops from the main bus station. The location is super easy to get to from both the main bus and rail station (with just one connection). It's also a very simple location from the Airport. We arrived via bus from Germany and but left via the airport. We took the metro from Malostranka (5 min walk from apartment) just a couple stops to a bus that took us to the airport. It was reliable, inexpensive and easy.
The location of the apartment was perfect. It is in a great location to choose either the touristy and busy areas of Pargue 1 or to quickly walk in the opposite direction and find yourself in a more quiet and less touristy section. We ended up being so happy that we didn't stay on the other side of the river and near the the old town square. The apartment is directly on a canal so you simply open your windows and see the tour boats float by and hear the ducks and geese in the canal below. The location is also a very easy 15 min walk to Prague Castle.