We just had 5 great weeks in Prague. The apartment is located neatly on the edge of the touristy area near the Old city, it was very easy and quick to walk to Wenceslas Square, Old Town Square every day. We simply did not use public transport for that.
The check-in was quick. It was easy to reach the building using public transport and a bit of walking. The instructions were clear, but you'd want to read them in full.
The daytime and evenings might be noisy as windows open to the street, but nights were actually pretty quiet. The apartment provides earplugs if that's not enough.
The kitchen was fully stocked, with plates, pans, pots, cups, and glasses. Everything was clean (and most were even new :)
The bed was big and comfortable, additional pillows were provided. Netflix was also available on TV.
All in all, it was a comfortable stay for us, sometimes working on our laptops during the day (WiFi is good) and going out in the evenings and on the weekends. We will gladly come back.