This is the best Airbnb we have stayed at anywhere in the world! It is a great location especially for a longer stay - everywhere was walk-able (Old Town Square is a 15-20 minute walk). The apartment is very big, larger than expected and has every amenity you could imagine. The bed is the main bedroom is quite comfortable and didn't get hot even in the peak of summer and is quiet throughout the night. It is located on the 4th floor but there is an elevator so luggage is no issue.
All of the recommended restaurants/bars we tried were really great as well. Definitely check out the bars on the boats on the river right next to the apartment. This is the only place I would stay in Prague!