Great location, if you want to be near Vaclavske Namesti and the rest.
I have generally been pleased with all my airbnb stays, but this one stands out as being subpar, primarily for three reasons. First, the sheets were not changed for our stay - we found dirt and hair on one of our beds. Second, when we booked our stay, it was not made clear that we would have to pick up they keys from an office, and then go to our place. With 2 little kids and suitcases, this would have been a pain - but luckily, we had some family to help us move around town. Third, expect the most basic of amenities - the owners claim to "have many apartments in the center of town and thus expect guests to meet them at their office" - and it shows that this apartment is a recent acquisition to their business. I will not stay in any places under the 'Abrupt' logo again.