This is a great place to stay in Prague. The Karlin district has lots of eateries and it is just a few minutes walk to the tram that takes you right into the center of town. The subway and bus station is not too far a walk either and the walk into town without any transit was 20 minutes for me, quite reasonable.
The neighborhood was very safe and central and the space was extremely clean, modern, and comfortable. It had everything that I needed for a 7 day stay. Sophia was very responsive to any requests I had and had lots of info about how to get around and places to go. She even arranged a car hire to pick me up at the airport for a reasonable rate. I highly recommend Sophia's space and look forward to staying here again the next time I visit Prague.