I lived in Letna, in Karlin and Zizkov and this was my first experience in the very center of Prague. Everything is within walking distance and you'll be able to make the most of your stay. Jan & Sarah were super friendly and provided all the needed info, while also being very responsive on whatsup. Moreover, the apartement is tastefully put together, windows facing the inner garden and making it very peaceful and quiet. Highly recommended, I will surely book it again if available for my next visit :)