The apartment's location could not be better (everything you need to see is within walking distance)!
It is also equipped with everything you need :)
The only thing to be aware of is that you will need to grab the keys at a different location than the apartment (an additional cab ride) and there is a noise-monitoring machine in the apartment due to neighbors having complained in the past - this was not an issue for us at all since we were traveling with our toddler and were in bed early (I also don't think it is an issue unless you are throwing a party).
Overall, the stay was wonderful and we would not hesitate going back! Prague is absolutely beautiful and you will not regret staying at Alex and Kate's Airbnb.