Beautiful place to stay in Prague. I lived in the city for many years, stayed as well at other homes and know places, districts. If you are looking for a perfect mix of being closed to everything and a peaceful sleep and a quiet morning at the terrace overlooking the mountains, then you do not have to look any further.
I now live in Barcelona where it is hard to find a quiet area, so for me excellent bed/pillows/sheets/spacious apartment/terrace and Marks&Spencer with their salads and other options of quick and healthy breakfast just 500m away - this is a dream stay.
It is not in the centre-centre, although Prague is a relatively small city, so you can get to the main attractions by walking or by Bolt/Uber which is super cheap, comparing to Spain.
There is Novy Smichov shopping centre, two cinemas nearby, Tesco shop just around the corner.
Apartment itself is just beautiful and perfectly planned. There were 4 of us, old friends, and we had so much fun playing board games, talking and laughing without any spotted neighbors. Either the walls/acoustics of the apartment are very solid, or the neighbors are not closed to the apartment, as we did not hear a thing.
Definitely the best stay in Prague!