This is one of the best places to say in Prague. It is in the city center near the National Museum and Wenceslas Square, a 5 minute walk away. There is a mini market (Žabka) nearby if you need to grab a quick breakfast or buy water.
Public transport is very close to the place (Metro, tram and bus).
The building itself is very modern on the inside. Self opening doors, access by a card or code, self check-in using a kiosk which is very easy to use. There are also vending machines that offer coffee and something to eat.
The room itself is very nice. It is very clean, spacious and it is beautiful. It had all amenities (soap, shampoo, water, washing machine, iron, safe, TV with many channels including Netflix, Youtube and etc.) a person would need for a stay for few days.
The staff is very nice and helpful. We left our luggage with the cleaning staff while we had a walk around Prague, because our flight was in the afternoon.
Communication is very easy through the Airbnb chat. I totally recommend it.
TLDR: Very nice place to stay in the center of Prague, friendly staff, easy check-in, amazing room with many amenities, totally recommend.