This is a perfect location for your trip to Prague! Clean and although you may feel like you're a bit away, you're actually in a perfect spot!
A few tips-
1. Mass Transportation is fantastic! The #9 will take you close to Old Town.
2. Don't be afraid to use the Metro (underground train) to check out the Palace area.
3. #191 Bus was about 3 city blocks from the apartment and we took it to the airport! About a 45 minute ride and easy!
4. Give yourself additional time at the airports. They're well run but thorough and it may take a bit longer than thought.
5. Wear great walking shoes- the cobble can be slippery and uneven. Plan to walk- it's a great, great walking town.
5. Check out Pragueexperience.com- they have great information.
6. There's a great city app- dpp.cz. Even the locals use it!