Whether you're staying 2 days or 22 days, you should consider staying at Anita's. The location in "Lesser Town" is convenient to everything--and I do mean, everything. If it's not within walking distance, just hop on the tram practically outside the front door.
Anita is a thoughtful host, staying in touch with you right up to your arrival and providing all the information/assistance you need to get there without hassle. Additionally, she maintains a nice stash of Prague books/maps for you to make use of. Best of all, she provides her own little tips for making the most of your stay.
The day we arrived, Anita greeted us at the door and was simply adorable in demeanor. She walked us through the entire apartment and made sure we knew how everything works (though, as mentioned above, she provides you with notes). A couple of times during our 8-day stay, we messaged back and forth; Anita was very prompt answering questions.
The apartment is lovely with all the necessary comforts of home. For example: After many hours on our feet touring the city, it was heavenly to get back to a comfortable sofa and toss a cozy sheep's wool blanket atop our feet. We loved that the mini refrigerator provided the option of bringing restaurant "takeaway" back to the apartment as well as allowing us to visit the small grocery down the street. The intimate balcony offered a refreshing spot to welcome in the new day, gaze at the skyline of historical buildings or simply listen to the people on the streets as the day came to an end. And, personally, it was wonderful not to have to go home with a suitcase full of dirty laundry! What a luxury the washer-dryer was.
After you've checked all the other places, do yourself a favor and book this one. It's worth every penny.