Great location, just a couple blocks away from the Charles Bridge. On the Main Street on the river, but there is no problem with noise as the windows all face an inner courtyard.
Only things to be aware of is there is no elevator and it is up three floors, so if that is a problem then watch out. Wasn't for us though, and we lugged our touring bikes and panniers up to store in the suite.
Brand new kitchen and bathroom, everything works great! Only thing I might recommend is a fan for the window to cool things down a bit more at night, but that is really nit picking. Highly recommended!